[An updated guide on drugs inducing ototoxicity, tinnitus and vertigo].
The argument of the iatrogenic side effects of pharmacological origin that can cause ototoxic effects or only disacustic symptoms like the tinnitus, without consequent degenerative effects, is enlarged in these last years. It is because of the great knowledge based on the careful attention from the pharmaceutical institutions which are responsible for the control of medicines and drugs. In the medical practice and in that specialty field born the need to gather, also in consideration of the possible medico-legal implications, those elements which will suppose the risk of otologic side effects. This will allow the physicians to evaluate the possible clinical advantage of a treatment, in their own field of competence, balancing them with their possible side effects in the otologic field. For this purpose, we have elaborated some updated lists of drugs with possible side effects of ototoxicity, tinnitus and vertigo; furthermore, we considered these drugs as could theoretically have influence on the auditory neurochemical progressing since they have excitatory or inhibitory action on the neurotransmitters and their receptors, but not signaled by the sources of institutional information.
Dipartimento di Otorinolaringoiatria, Audiologia, Foniatria "G. Ferreri", Università di Roma La Sapienza, Roma. giancarlo.cianfrone@uniroma1.it
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Cianfrone
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Pace
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Turchetta
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Cianfrone
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Altissimi
D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology*; D064420:Drug-Related Side Effects and Adverse Reactions; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000503:physiopathology*; D006801:Humans; D014012:Tinnitus / Q000139:chemically induced*; D014717:Vertigo / Q000139:chemically induced*