Glucose-insulin and potassium infusions in septic shock.
Glucose-insulin and potassium (GIK) infusions are beneficial in treating ischemic myocardial depression. Myocardial depression is also an important feature in septic shock. We describe two cases of pressor-resistant hypodynamic septic shock that responded to high-dose GIK infusions. In each case, hemodynamic profiles improved sufficiently to allow withdrawal of vasopressor agents. Further assessment of GIK in patients with hypodynamic septic shock is necessary to confirm efficacy and prognostic significance.
Department of Intensive Care Medicine, University College London Foundation Hospitals, The Middlesex Hospital, London W12 0HS, UK. sh_hamdu@hotmail.com
Shahir S
SS
Hamdulay
Ali
A
Al-Khafaji
Hugh
H
Montgomery
D000328:Adult; D002302:Cardiac Output / Q000187:drug effects; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D004837:Epinephrine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
D002314:Cardioplegic Solutions; D007328:Insulin; D014662:Vasoconstrictor Agents; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium; D004837:Epinephrine