Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).
Schürks
M
M
Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany. schuerks@hotmail.com
Kurth
T
T
Geissler
I
I
Tessmann
G
G
Diener
H-C
HC
Rosskopf
D
D
D000328:Adult; D003027:Cluster Headache / Q000453:epidemiology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D064446:Orexin Receptors; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide