Concise asymmetric total synthesis of obolactone.
The first efficient asymmetric synthesis of obolactone 1 has been accomplished in 11 steps and with a 15% overall yield in which Brown's enantioselective allylation reactions and ring-closing metathesis reaction are key steps.
Zhang
Jiyong
J
Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Li
Yang
Y
Wang
Wenkuan
W
She
Xuegong
X
Pan
Xinfu
X
D000447:Aldehydes / Q000737:chemistry; D002074:Butanones / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D002074:Butanones; D007783:Lactones; C516119:obolactone; C025383:benzylideneacetone