The "stamp method": a new treatment for perforated peptic ulcer?
BACKGROUND
The aim of this study was to develop a simple method for closure of a perforated peptic ulcer, making it more accessible for laparoscopic surgery.


METHODS
An experimental pilot study was performed using five male Wistar rats. The perforation was closed by a bioabsorbable patch made of lactide-glycolid-caprolactone fixed with glue onto the outside of the stomach.


RESULTS
Postoperatively, there were no signs of leakage or other complications. Histologically, there were no signs of inflammation on the inside of the stomach, and there was a 50% reduction of the perforation each successive postoperative week. No adverse reactions because of the degradable material or glue were observed.


CONCLUSIONS
Treatment of a perforated peptic ulcer by placing a patch of biodegradable material like a "stamp" on the outside of the stomach is a feasible option.
Department of Plastic Surgery, Academic hospital Groningen, Hanzeplein 1, P.O. Box 30001, Groningen, 9700 RB, The Netherlands. m.j.o.e.bertleff@chir.azg.nl
M J O E
MJ
Bertleff
R S B
RS
Liem
H L
HL
Bartels
P H
PH
Robinson
J F A
JF
Van der Werff
H J
HJ
Bonjer
J F
JF
Lange
D020341:Absorbable Implants; D000818:Animals; D007813:Laparotomy; D008297:Male; D010439:Peptic Ulcer Perforation / Q000473:pathology / Q000601:surgery*; D011091:Polyesters; D051381:Rats; D017208:Rats, Wistar; D012086:Reoperation; D013997:Time Factors
D011091:Polyesters; C062968:lactide-caprolactone copolymer