The role of the stroma in carcinogenesis.
This systematic review considers the most recent attitudes and news regarding the influence of the stroma on tumor initiation and progression. It is now widely accepted that tumor stroma plays an active role in carcinogenesis. Many different signaling molecules, ligands and signaling pathways recently have been discovered. This review considers the complexity of interactions between malignant cells and its stroma (cross-talk). The recent advances and better understanding of the tumor-stroma interactions will have important impact on the new and combined therapeutic approaches and modalities.
Bilalović
Nurija
N
Department of Clinical Pathology and Cytology, Clinical Center of the University of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina.
Vranić
Semir
S
Serdarević
Fadila
F
Foco
Faris
F
D002450:Cell Communication; D016922:Cellular Senescence; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D015398:Signal Transduction; D017154:Stromal Cells / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta