One-pot synthesis in aqueous system for water-soluble chitosan-graft-poly(ethylene glycol) methyl ether.
Chitosan is functionalized with poly(ethylene glycol) methyl ether (mPEG) at the amino and hydroxyl groups via a single step reaction in a homogeneous aqueous system. A chitosan aqueous solution obtained from the mixture of chitosan and hydroxybenzotriazole (HOBt) in water is a key factor in providing mild conditions to conjugate mPEG by using a carbodiimide conjugating agent. The reaction at ambient temperature for 24 h gives chitosan-g-mPEG with water solubility with mPEG content as high as 42%. This work demonstrates that a water-soluble chitosan-HOBt complex is an effective system for the preparation of chitosan derivatives via the aqueous system without the use of acids or organic solvents.
The Petroleum and Petrochemical College, Chulalongkorn University,Phya Thai,Bangkok 10330,Thailand.
J
J
Fangkangwanwong
Mitsuru
M
Akashi
Toshiyuki
T
Kida
Suwabun
S
Chirachanchai
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014230:Triazoles / Q000737:chemistry; D014867:Water
D001672:Biocompatible Materials; D001704:Biopolymers; D014230:Triazoles; D014867:Water; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D048271:Chitosan; C011852:1-hydroxybenzotriazole