[Interleukin-1beta C+3953T gene polymorphism and peripheral arterial occlusive disease in Polish population].
The proinflammatory cytokines, like interleukine-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), have been suggested to play a role in the development of atherosclerotic conditions, e.g. peripheral arterial occlusive disease (PAOD). Several genetic polymorphisms were described within the cluster of the IL-1 genes. The allelic variant C+3953T of the interleukin-1beta (IL-1beta) gene correlated with the cytokine level in vitro. The aim of this study was to estimate frequency of IL-1beta +3953 polymorphism in the Polish population and to test for its association with PAOD. We genotyped IL-1beta gene in 115 PAOD patients and 153 healthy controls. Genotypes distribution and allelic frequencies of C+3953T polymorphism did not differ between PAOD and controls. Thus, no association was observed between functional IL-1beta polymorphism and PAOD in our study. Frequency of the variant +3953T allele in Polish subjects (0.258) was similar to this found in other populations.
II Katedra Chorób Wewnetrznych, Collegium Medicum, Uniwersytetu Jagiellońskiego.
Daniel P
DP
Potaczek
Marek
M
Krzanowski
Marek
M
Sanak
D000328:Adult; D000483:Alleles; D001157:Arterial Occlusive Diseases / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*
D007375:Interleukin-1