2,3-diphosphoglycerate and oxygen supply of tissues in cardiosurgical diabetics.
OBJECTIVE
The oxygen supply of tissues was studied under haemodilution in cardiosurgical diabetic and non-diabetic patients.


METHODS
There were 30 cardiosurgery patients examined, 9 were patients with diabetes mellitus.and 21 were non-diabetic patients. Venous blood samples were examined preoperatively, intraoperatively and for 10 days after operation.


RESULTS
Haemodilution caused a decrease in haematocrit values in both groups, as well as in the erythrocyte count and haemoglobin concentration. Postoperatively, an increase was recorded in haematological values in both groups, the values had not reached the baseline even by 10th day. Increased values of blood oxygen saturation and partial oxygen pressure during the operation returned to baseline in both groups in the postoperative days. Values of p50 did not change in both groups for the period of observation.


CONCLUSIONS
The obtained data suggest that sufficient oxygen supply to tissues was ensured under haemodilution in cardiosurgery patients in both groups. These results confirm multifactorial dependence of blood oxygen transport to tissues (Tab. 1, Fig. 3, Ref. 13).
Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. igor.beder@fmed.uniba.sk
I
I
Beder
A
A
Mataseje
M
M
Kittova
J
J
Carsky
V
V
Fischer
D019794:2,3-Diphosphoglycerate / Q000097:blood*; D001026:Coronary Artery Bypass; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004906:Erythrocyte Count; D006400:Hematocrit; D006438:Hemodilution; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*
D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D010100:Oxygen