[Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: final height in 27 patients with the classical form].
OBJECTIVE
To determine final height (FH) in congenital adrenal hyperplasia (CAH) patients and investigate conditions allowing better height outcome.


METHODS
13 salt-wasting (SW) and 14 simple virilizing (SV) patients were studied. FH and target height (TH) were transformed into standard deviation score (z). Data were analyzed according to sex, clinical form, age at treatment onset and length of treatment before attaining FH.


RESULTS
zFH (n = 27) was -1.57 +/- 1.01. FH (-1.50 +/- 1.03) was below TH (-0.78 +/- 0.84) (n = 25, p < 0.001). FH has not differed according to sex, clinical form and age at therapy onset although there was a trend towards better FH in SW patients and in early treated cases; there was significant difference (p = 0.018) between patients treated for less than 5 years (-2.49 +/- 1.03) and those accompanied longer than 10 years (-1.21 +/- 0.88) before attaining FH.


CONCLUSIONS
There was a FH impairment and adult height improvement seems to depend mainly on early diagnosis and treatment.
Departamento de Pediatria, Ciped, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP. sofia@hc.unicamp.br
Sofia H V
SH
Lemos-Marini
Gil
G
Guerra-Júnior
André M
AM
Morcillo
Maria Tereza M
MT
Baptista
Luciana O
LO
Silva
Andréa T
AT
Maciel-Guerra
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy / Q000503:physiopathology*; D000704:Analysis of Variance; D001827:Body Height / Q000187:drug effects / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008901:Mineralocorticoids / Q000627:therapeutic use; D011379:Prognosis; D018709:Statistics, Nonparametric; D013255:Steroid 21-Hydroxylase / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D008901:Mineralocorticoids; D013255:Steroid 21-Hydroxylase