Amphotericin B-induced severe hypertension in a young patient: case report and review of the literature.
The description of the association between the use of amphotericin-B (amB) and the development of systemic arterial hypertension was only anecdotal so far. We describe the case of a 19-year-old female patient who had acute lymphoblastic leukemia and developed prolonged neutropenia after reinduction chemotherapy. Candida parapsilosis was isolated from blood cultures, and amB was started. Sustained severe arterial hypertension developed shortly after amB administration and continued for several hours after the infusion. Aldosterone, blood urea nitrogen, and creatinine levels were normal. After clinical improvement, amB was replaced by fluconazole, and blood pressure normalized. Severe hypertension may be an adverse event associated with AmB treatment that requires intensive treatment.
Division of Hematology, Department of Medicine, Universidade Federal De São Paulo, São Paulo, Brazil. celsoarrais@uol.com.br
Celso Arrais
CA
Rodrigues
Mihoko
M
Yamamoto
Adriano de Moraes
Ade M
Arantes
Maria de Lourdes L F
Mde L
Chauffaille
Arnaldo Lopes
AL
Colombo
José Orlando
JO
Bordin
D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D012720:Severity of Illness Index
D000935:Antifungal Agents; D000666:Amphotericin B