Primary sclerosing cholangitis treated by endoscopic biliary dilation: review and long-term follow-up evaluation.
Primary sclerosing cholangitis (PSC) is an important cause of chronic liver disease. We review the management of PSC and report a 20-year follow-up of our initial 10 patients. This is the longest detailed follow-up of a group of PSC patients to date. We discuss the clinical course and results of endoscopic management in these patients and relate these data to management of PSC in general. We compare the actual survival of these patients to predicted survival scores based on the Mayo multicenter survival model. Although our patients presented with cholangitis, which typically reflects advanced stages of liver disease, their survival compares favorably with expected survival in unselected PSC patients. Endoscopic balloon dilation of PSC patients presenting with biliary strictures and cholangitis may have long-term benefit in addition to short-term symptomatic relief.
Johnson
G Kenneth
GK
Division of Gastroenterology and Hepatology, The Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226, USA.
Saeian
Kia
K
Geenen
Joseph E
JE
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000601:surgery; D001660:Biliary Tract Diseases / Q000150:complications / Q000628:therapy; D002423:Cause of Death; D018281:Cholangiocarcinoma / Q000150:complications / Q000601:surgery; D015209:Cholangitis, Sclerosing / Q000401:mortality / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis