Anti-CD38 autoantibodies in type? diabetes.
Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin action (so-called insulin resistance) associated with impaired beta cell function. However, it is becoming increasingly clear that there is a certain overlap between these two diseases. While some degree of insulin resistance is present in type 1 diabetic patients, markers of beta cell autoimmunity (either primary or secondary) can frequently be detected in type 2 diabetic subjects. In this scenario, anti-CD38 autoantibodies (aAbs) have been described in both type 1 and type 2 diabetic patients. Contrary to the other known islet aAbs, anti-CD38 autoantibodies are more prevalent in long-standing than in new-onset type 1 diabetes, and more prevalent in type 2 than in type 1 diabetes. Moreover, anti-CD38 aAbs are endowed with unique stimulatory properties on Ca(2+) mobilization and insulin secretion. These observations suggest that autoimmunity may be both the cause and consequence of beta cell dysfunction, in either case imposing a further toll for the control of glucose homeostasis.
INSERM U580, Institut Necker, U580-Batiment Sevres, 161 rue de Sèvres, 75015 Paris, France. mallone@necker.fr
Roberto
R
Mallone
Paolo Cavallo
PC
Perin
D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000276:immunology; D018448:Models, Immunological
D001323:Autoantibodies; D051997:ADP-ribosyl Cyclase 1