Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy.
The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS) for epilepsy. Five patients (all AN) had > or = 50% seizure reduction, although benefit was delayed in two until years 5 to 6, after changes in antiepileptic drugs. DBS electrode implantation in AN patients was followed by seizure reduction 1 to 3 months before active stimulation, raising the possibility of a beneficial microthalamotomy effect.
Division of Neurology, Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
D M
DM
Andrade
D
D
Zumsteg
C
C
Hamani
M
M
Hodaie
S
S
Sarkissian
A M
AM
Lozano
R A
RA
Wennberg
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D003131:Combined Modality Therapy; D046690:Deep Brain Stimulation / Q000009:adverse effects; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000628:therapy; D004827:Epilepsy / Q000188:drug therapy / Q000628:therapy*; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology; D016037:Single-Blind Method; D012894:Sleep Stages; D013788:Thalamus; D017211:Treatment Failure
D000927:Anticonvulsants