Decreased growth capacity of passaged gross virus-induced mouse lymphomas after incubation with antithymocytic sera.
AKR or C3H/HeJ transplanted mouse lymphomas, originally induced by Gross virus, could be neutralized by in vitro incubation with an immunosuppressive rabbit anti-mouse thymus cell serum. Neutralization was measured by significantly increased latent periods or decreased incidence (at a minimum of 90 days post-transfer) of lymphoma in syngeneic recipients of lymphoma cells incubated with antithymocytic serum when compared with syngeneic recipients of lymphoma cells incubated with normal rabbit serum.
Laboratory of Nuclear Medicine and Radiation Biology, School of Nursing, University of California, Los Angeles, California 90024.
D L
DL
Vredevoe
E F
EF
Hays