[High doses of inhaled budesonide and adrenal function in children with severe asthma].
BACKGROUND
The use of inhaled steroids is common in the treatment of bronchial asthma in children.


OBJECTIVE
To assess adrenocortical function in children with severe asthma receiving inhaled budesonide for six or more months.


METHODS
Children with severe asthma that required 800 microg/day or more of inhaled budesonide and that did not required systemic steroids for more than six days in the last four months to control their disease, were studied. Serum cortisol was measured one hour after administration of 0.25 mg of ACTH (Cosyntropin) intravenously. The test was considered normal if post stimulation serum cortisol was over 18 microg/ml.


RESULTS
Twenty children (aged 5 to 14 years, 15 males), were studied. The stimulation test was normal in 17 children.


CONCLUSIONS
Alterations in adrenal function are present in a small proportion of asthmatic children who require 800 microg/day of inhaled budesonide.
Departamento de Pediatría, Escuela de Medicina, Universidad de Valparaíso, Chile. pediatria@uv.cl
Aída
A
Milinarsky T
Sylvia
S
Fischer G
Vinka
V
Giadrosich R
Viviana
V
Lezana S
María Teresa
MT
Torres C
D000280:Administration, Inhalation; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects*; D000304:Adrenal Cortex Function Tests; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D019819:Budesonide / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
D001993:Bronchodilator Agents; D019819:Budesonide; D006854:Hydrocortisone