Intravenous injection of methylprednisolone reduces the incidence of postextubation stridor in intensive care unit patients.
OBJECTIVE
To determine whether treatment with corticosteroids decreases the incidence of postextubation airway obstruction in an adult intensive care unit.


METHODS
Clinical experiment.


METHODS
Adult medical and surgical intensive care unit of a teaching hospital.


METHODS
One hundred twenty-eight patients who were intubated for >24 hrs with a cuff leak volume <24% of tidal volume and met weaning criteria.


METHODS
: Patients were randomized into a placebo group (control, n = 43) receiving four injections of normal saline every 6 hrs, a 4INJ group (n = 42) receiving four injections of methylprednisolone sodium succinate, or a 1INJ group (n = 42) receiving one injection of the corticosteroid followed by three injections of normal saline. Cuff volume was assessed 1 hr after each injection, and extubation was performed 1 hr after the last injection. Postextubation stridor was confirmed by examination using bronchoscopy or laryngoscopy.


RESULTS
The incidences of postextubation stridor were lower both in the 1INJ and the 4INJ groups than in the control group (11.6% and 7.1% vs. 30.2%, both p < .05), whereas there was no difference between the two treated groups (p = .46). The cuff leak volume increased after the second and fourth injection in the 4INJ group and after a second injection in the 1INJ group compared with the control group (both p < .05).


CONCLUSIONS
A reduced cuff leak volume is a reliable indicator to identify patients at high risk to develop stridor. Treatment with a single or multiple injections of methylprednisolone can effectively reduce the occurrence of postextubation stridor.
Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Kuo-Chen
KC
Cheng
Ching-Cheng
CC
Hou
Heng-Ching
HC
Huang
Shu-Chih
SC
Lin
Haibo
H
Zhang
D000368:Aged; D000369:Aged, 80 and over; D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012131:Respiratory Insufficiency / Q000209:etiology / Q000517:prevention & control*; D012135:Respiratory Sounds / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone