A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia.
Uncommon polymorphisms, particularly balanced uncommon polymorphisms, present a significant challenge to our understanding of their role in behavior. We have recently demonstrated that an uncommon candidate gene polymorphism for schizophrenia, known as HOPA12bp, is the defining polymorphism for a large X-chromosome haplotype in population disequilibrium and that it is associated with a positive syndrome of psychosis. Not all studies, however, have shown this effect. In this report, we reviewed prior studies and conducted meta-analysis of studies using probands of northern European extraction. We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association.
Philibert
Robert A
RA
Department of Psychiatry, Neuroscience Program, The University of Iowa, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu
D000483:Alleles; D041321:Chromosomes, Human, X / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D056892:Mediator Complex; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011988:Receptors, Thyroid Hormone / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis / Q000235:genetics*
C460107:MED12 protein, human; D056892:Mediator Complex; D011988:Receptors, Thyroid Hormone