Orthodontic treatment of patients with sickle-cell anemia.
Sickle-cell anemia is a genetic blood disease characterized by a hemoglobin gene mutation. The genetic failure is basically constituted by replacement of the hemoglobin beta chain in the sixth position so that the amino acid valine is encoded instead of glutamic acid. As a result, the erythrocytes have their normal biconcave discoid shape distorted, generally presenting a sicklelike shape, which reduces both their plasticity and lifetime. Because a complete blood supply is so important during application of both intraoral and extraoral forces, this article addresses the general and oral aspects associated with sickle-cell anemia. This will guide the clinician regarding such patients who seek orthodontic treatment by making references to literature on multidisciplinary management.
Federal University of Rio de Janeiro, Orthodontics, Rio de Janeiro 21941-590, Brazil. patricia.alves@ortodontia.ufrj.br
Patricia Valéria Milanezi
PV
Alves
Daniele Karina M
DK
Alves
Margareth Maria Gomes
MM
de Souza
Sandra Regina
SR
Torres
D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D017742:Dental Care for Chronically Ill / Q000379:methods*; D004913:Erythrocytes, Abnormal / Q000378:metabolism*; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D009971:Orthodontics, Corrective / Q000379:methods*
D006451:Hemoglobin, Sickle