[Comparison of unconsciousness prediction probability with approximate entropy and bispectral index during sedation].
OBJECTIVE
To compare the unconsciousness prediction probability (Pk) estimated by approximate entropy (ApEn) and bispectral index (BIS) during the sedation produced by target-controlled infusion (TCI) of propofol.


METHODS
Twenty patients (ASA class I-II) scheduled for elective lower limb operations under epidural anesthesia were studied. TCI of propofol was initiated at target plasma concentration of 0.5 microg/ml, and increased by 0.3 to 0.5 microg/ml until loss of consciousness, and then decreased until consciousness recovery. Each target plasma concentration of propofol lasted for 12 min. ApEn and BIS were recorded simultaneously during the periods of consciousness and unconsciousness every 3 min. The Pk of unconsciousness with ApEn and BIS were calculated and compared.


RESULTS
ApEn was 0.84+/-0.05 in the state of consciousness and 0.71+/-0.06 upon loss of consciousness, and BIS in the corresponding stages were 80.2+/-6.2 and 67.3+/-7.9, respectively. The Pk of unconsciousness between ApEn (Pk=0.97+/-0.06) and BIS (Pk=0.91+/-0.11) did not significantly differ (P>0.05).


CONCLUSIONS
ApEn as well as BIS is acceptable for predicting consciousness and unconsciousness produced by TCI propofol.
Ouyang
Ming-wen
MW
Department of Anesthesiology, General Hospital of PLA, Beijing 100853, China. ouyangmm2008@yahoo.com.cn
Zhang
Hong
H
D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D016292:Procedural Sedation / Q000379:methods; D003243:Consciousness / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D015742:Propofol