Long-term changes in blood pressure in extremely obese patients who have undergone bariatric surgery.
OBJECTIVE
Systolic and diastolic pressure and the incidence of hypertension in very obese patients decline after bariatric surgery and do not rebound.


METHODS
Chart review.


METHODS
Surgical practice in a university medical center.


METHODS
Women and men, 18 years or older, with a body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) of 40 or greater, having no previous surgical intervention for extreme obesity.


METHODS
Vertical-banded gastroplasty or Roux-en-Y gastric bypass.


METHODS
Systolic and diastolic blood pressure, BMI, and antihypertensive medications.


RESULTS
Patients underwent Roux-en-Y gastric bypass (n = 285; mean initial BMI, 55.7) or vertical banded gastroplasty (n = 62; mean initial BMI, 48.5); half of each group was hypertensive at evaluation. The BMI dropped in both groups after surgery and stabilized at about 35 within 18 months. Systolic pressure changes were generally modest, although diastolic pressure declined significantly after surgery. In patients with untreated stage 1 hypertension, marked reductions in systolic and diastolic pressures occurred after surgery. Many patients taking antihypertensive medications before surgery discontinued them after surgery and remained normotensive.


CONCLUSIONS
Blood pressure reductions that occur after bariatric surgery and substantial weight loss depend on the blood pressure status of patients before surgery: normotensive patients and hypertensive patients taking antihypertensive medications show small postsurgical pressure reductions, while patients with elevated blood pressure before surgery show notable postsurgical pressure drops. The overall incidence of hypertension after bariatric surgery declines substantially and remains low.
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. fernstromjd@upmc.edu
John D
JD
Fernstrom
Anita P
AP
Courcoulas
Patricia R
PR
Houck
Madelyn H
MH
Fernstrom
D000328:Adult; D000367:Age Factors; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D015391:Gastroplasty; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D012189:Retrospective Studies