Primary malignant peripheral nerve sheath tumor of the lung in a young child without neurofibromatosis type 1.
Malignant peripheral nerve sheath tumors (MPNST) are uncommon in children and almost half of the cases occur in patients with neurofibromatosis 1 (NF1). We report a child with a primary MPNST of the lung without NF1. MPNST of the lung has similar clinical and radiologic characteristics as pleuropulmonary blastoma. We suggest to include MPNST of the lung in the differential diagnosis of intrapulmonary masses in children.
Children's Cancer Center of Lebanon, American University of Beirut, Beirut, Lebanon, and Department of Hematology and Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA. sm03@aub.edu.lb
Samar A
SA
Muwakkit
Carlos
C
Rodriguez-Galindo
Ahmad I
AI
El Samra
Ruby
R
Khoury
Samir R
SR
Akel
Salman
S
Mroueh
Bassem
B
Razzouk
Miguel R
MR
Abboud
D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000175:diagnosis; D011237:Predictive Value of Tests; D018202:Pulmonary Blastoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods