Modest hypothermia as a neuroprotective strategy in high-risk term infants.
This article briefly reviews the pathogenesis of hypoxic-ischemic cerebral injury, the experimental data, and clinical studies that have evaluated the potential therapeutic benefit of modest selective or whole body hypothermia in reducing the subsequent development of irreversible brain injury without untoward side effects. Data are insufficient to recommend routine use of either modest selective or whole body hypothermia after resuscitation of infants with suspected asphyxia. Further clinical trials are needed to determine which infants would benefit most and which method of cooling would be most effective.
Department of Neonatology, Texas Children's Hospital, Houston, TX 77030, USA.
Michael
M
Speer
Jeffrey M
JM
Perlman
D000138:Acidosis / Q000150:complications; D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000517:prevention & control*; D007231:Infant, Newborn; D011247:Pregnancy; D012307:Risk Factors; D047929:Term Birth