Dynamical structure of peptide molecules.
In view of the importance of the peptide linkage in structural biology, we have carried out intensive investigations on peptide molecules consisting of a peptide linkage with one or two substituents in the gas phase by Fourier transform microwave spectroscopy, paying special attention to the internal rotation of the substituents relative to the central linkage framework. We have found that, in sharp contrast with the stiff structure around the central C-N bond of the linkage, the internal rotations of the substituents are of low frequency and thus of large amplitude and are extremely susceptible to their local environment such as the presence of other substituents.
Kawashima
Yoshiyuki
Y
Department of Applied Chemistry, Kanagawa Institute of Technology, Atsugi, Kanagawa 243-0292, Japan.
Usami
Tsuyoshi
T
Ohashi
Nobukimi
N
Suenram
Richard D
RD
Hougen
Jon T
JT
Hirota
Eizi
E
D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017550:Spectroscopy, Fourier Transform Infrared
D010455:Peptides