Chemical ligation--an unusual paradigm in protease inhibition.
Some protease inhibitors use uncommon mechanisms to restrain the activity of their target enzymes. A recent paper in Chemistry and Biology (Lu et al., 2006) demonstrates a curious mechanism of inhibition of a caspase, relying on principles of native peptide ligation.
Stennicke
Henning R
HR
Department for Haemostasis Biochemistry, Biopharmaceuticals Research Unit, Novo Nordisk, Novo Nordisk Park, DK-2760 Måløv, Denmark.
Salvesen
Guy S
GS
D017209:Apoptosis; D061945:Caspase Inhibitors; D047668:Inteins / Q000502:physiology; D008954:Models, Biological; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014764:Viral Proteins / Q000502:physiology
D061945:Caspase Inhibitors; D011480:Protease Inhibitors; D014764:Viral Proteins; C492234:p35 protein, Baculovirus