Synthesis and fungicidal activity of N-2-(3-methoxy-4-propargyloxy)phenethyl amides. Part II: anti-oomycetic mandelamides.
Novel types of anti-oomycetic compounds have been designed and prepared. The synthetic approach to these mandelamides is outlined. Biological data demonstrate their high efficacy against important plant diseases such as tomato and potato late blight (Phytophthora infestans De Bary) and grape downy mildew (Plasmopara viticola Berliner & de Toni). Structure-activity relationship studies are discussed. The new development product mandipropamid is presented.
Lamberth
Clemens
C
Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland. clemens.lamberth@syngenta.com
Cederbaum
Fredrik
F
Jeanguenat
Andre
A
Kempf
Hans-Joachim
HJ
Zeller
Martin
M
Zeun
Ronald
R
D044482:Benzeneacetamides / Q000138:chemical synthesis / Q000737:chemistry; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000737:chemistry; D008333:Mandelic Acids / Q000138:chemical synthesis / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009868:Oomycetes; D010838:Phytophthora
D044482:Benzeneacetamides; D005659:Fungicides, Industrial; D008333:Mandelic Acids; C010413:mandelamide