[Study of cellular electrophysiology based on Noble98 dynamic model of ventricular action potential].
On the basis of mammalian ventricular action potential model Noble98, and with the use of Runge-Kutta for solution, the Wenckebach periodicity phenomenon, the transmural heterogeneity of the ventricular myocardium and its rate dependence are studied. The results indicate that these inherent properties may, lead to temporal-space disorganized in the normal heart,and may become the underlying factors for arrhythmias. At the same time, in this study are established the basic methods for quantitative cellular electrophysiology which is essential for future studies on the mechanism of arrhythmia.
Zhang
Hong
H
The Key Laboratory of Biomedical Information Engineering of Ministry of Education of China, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. maxr@263.net
Yang
Lin
L
Jin
Yinbin
Y
Zhang
Zhenxi
Z
Huang
Yizhuo
Y
D000200:Action Potentials / Q000502:physiology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003198:Computer Simulation; D004594:Electrophysiology; D006329:Heart Conduction System / Q000502:physiology; D006352:Heart Ventricles; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*
D007473:Ion Channels