Baseline plasma C-reactive protein concentrations influence lipid and lipoprotein responses to low-fat and high monounsaturated fatty acid diets in healthy men.
To date, no studies have compared the effects of consuming a low-fat diet and a high monounsaturated fatty acid (MUFA) diet, under unrestricted energy intake conditions, on plasma C-reactive protein (CRP) concentrations. Men [n = 61; 37.5 +/- 11.5 y old (mean +/- SD), mean BMI 29.0 +/- 5.0 kg/m2] were randomly assigned to consume ad libitum a moderately low-fat diet (25.8% of energy intake from fat) or a high-fat diet rich in MUFA (40.1% of energy intake from fat, 22.5% from MUFA) for 6-7 wk. Plasma CRP concentrations were measured using a highly sensitive assay. Neither diet affected the plasma CRP concentration. However, baseline CRP concentrations predicted lipoprotein/lipid responsiveness to the experimental diets. After intake of the low-fat diet, plasma total and VLDL-triglyceride (TG) concentrations were increased in the subgroup with high CRP concentrations (P < 0.05 and P < 0.01, respectively) whereas they were reduced in the subgroup with low CRP concentrations at baseline (P < 0.01 for both). The high-MUFA diet reduced plasma TG, VLDL-TG, and VLDL cholesterol only in the subgroup with low CRP at baseline (P < 0.0001). In conclusion, the low-fat diet and the high-MUFA diet did not affect plasma CRP concentrations. However, baseline plasma CRP concentrations may modulate the diet-induced changes in plasma lipid and lipoprotein concentrations.
Desroches
Sophie
S
Institute on Nutraceuticals and Functional Foods, Laval University, QC, Canada.
Archer
W Roodly
WR
Paradis
Marie-Eve
ME
Dériaz
Olivier
O
Couture
Patrick
P
Bergeron
Jean
J
Bergeron
Nathalie
N
Lamarche
Benoît
B
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D015243:Cholesterol, VLDL / Q000097:blood; D018752:Diet, Fat-Restricted; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D002149:Energy Intake; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D015243:Cholesterol, VLDL; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; D002097:C-Reactive Protein