[Advances in researches on the mechanism and prevention of chronic kidney graft dysfunction].
In the 21st century, one of the focuses in the field of organ transplantation is the prevention of chronic kidney graft dysfunction (CKGD) and the furtherance of the long-term survival rate. Researches on the mechanism and prevention of CKGD have made progress in the important immune and nonimmune factors of CKGD. Researchers' endeavors to establish the model of CKGD in the animals such as inbreeding pigs; to develop new drugs which are characterized by high efficacy, low toxicity, low cost, and synergy when used together with immune depressants available from natural medicine; and to probe deeply into the mechanism and prevention of CKGD, will be the important aspects in the field of organ transplantation in the 21st century.
Feng
Li
L
Key Laboratory of Transplant Engineering and Immunology, West China Hospital of Sichuan University, Chengdu 610041, China. feng31@sohu.com
Li
Youping
Y
D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000517:prevention & control*; D016030:Kidney Transplantation / Q000009:adverse effects*; D015427:Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors