Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).
The introduction of (7'S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7'R)-methylation disrupts hybridisation significantly.
School of Chemistry, University of Manchester, Faraday Building, Sackville Street, PO Box 88, Manchester, UKM60 1QD.
Anila I
AI
Khan
T H Samuel
TH
Tan
Jason
J
Micklefield
D000577:Amides / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D009841:Oligonucleotides; D011759:Pyrrolidines; C032519:pyrrolidine