[Epithelioid hemangioendothelioma of bone complicated by femoral fracture].
A 54-year-old man was seen with a fracture of the left femur. Plain radiographs revealed a 40-mm lytic centromedullary lesion. Magnetic resonance T1- and T2-weighted sequences showed high and low signals. After stabilization of the fracture, the tumor was removed followed by reconstruction with a vascularized fibula. The pathological examination demonstrated proliferation of non atypical CD34 and CD31 positive epithelioid cells with few lumens, accompanied by abundant fibrous stroma, sometimes masking tumor cells. Satisfactory motion was achieved with no recurrence at 20 months follow-up. Bone hemangioendothelioma can simulate metastasis and must be distinguished by immunohistochemistry. Prognosis is a subject of debate as the tumor is considered to exhibit intermediate malignancy by some authors while other consider it to be a malignant tumor.
Service d'Anatomie et Cytologie Pathologique, Institut Salah-Azaiez, Tunis, Tunisie.
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Charfi
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Mrad
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Karray
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Sassi
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Driss
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Abbes
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Ben Romdhane
D005264:Femoral Fractures / Q000209:etiology*; D005266:Femoral Neoplasms / Q000150:complications* / Q000175:diagnosis; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged