Candidemia in pediatric patients with congenital heart disease.
Candidemia is an important problem in pediatrics. In our hospital, highest candidemia rates were documented among children with congenital heart disease (CHD). A series was conducted to describe the clinical and mortality features of candidemia in these patients. Fifty-two cases (1988-2000) included very young infants (median age, 2 months) who received long-term antibiotic treatment (median, 20.5 days). Candida parapsilosis predominated (54%). Endovascular infections occurred in 11.5%. In-hospital mortality was 39% and related mortality 14%. Maintenance of catheter (odds ratio [OR], 6.0; 95% confidence interval [CI], 1.0-37.2; P = .05) and severity of patients as measured with the Pediatric Risk Score of Mortality I (OR, 1.1, 95% CI, 1.0-1.3; P = .05) were independently associated with mortality. In summary, candidemia in children with CHD is diagnosed to very young infants with prolonged antibiotic therapy. Mortality is high but, in most cases, is not related to candidemia. Optimal management may include exclusion of endocarditis, early antifungal treatment, and catheter removal.
San Miguel
Lucía García
LG
Infectious Diseases Department, Ramon y Cajal Hospital, 28034 Madrid, Spain. lgarcias.hrc@salud.madrid.org
Cobo
Javier
J
Otheo
Enrique
E
Martos
Isabel
I
Muriel
Alfonso
A
Fortún
Jesús
J
Moreno
Santiago
S
D000293:Adolescent; D002177:Candidiasis / Q000150:complications* / Q000401:mortality; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D002408:Catheters, Indwelling / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D016469:Fungemia / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D006330:Heart Defects, Congenital / Q000382:microbiology* / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D015278:Intensive Care Units, Pediatric