Avian flu: influenza virus receptors in the human airway.
Although more than 100 people have been infected by H5N1 influenza A viruses, human-to-human transmission is rare. What are the molecular barriers limiting human-to-human transmission? Here we demonstrate an anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses. The respective molecules are sialic acid linked to galactose by an alpha-2,3 linkage (SAalpha2,3Gal) and by an alpha-2,6 linkage (SAalpha2,6Gal). Our findings may provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs.
Shinya
Kyoko
K
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Ebina
Masahito
M
Yamada
Shinya
S
Ono
Masao
M
Kasai
Noriyuki
N
Kawaoka
Yoshihiro
Y
D000818:Animals; D001717:Birds / Q000821:virology; D001980:Bronchi / Q000378:metabolism / Q000821:virology*; D005690:Galactose / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000378:metabolism*; D009980:Influenza A virus / Q000378:metabolism; D019158:N-Acetylneuraminic Acid / Q000737:chemistry / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000821:virology*; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000378:metabolism / Q000821:virology; D013045:Species Specificity
D011991:Receptors, Virus; D019158:N-Acetylneuraminic Acid; D005690:Galactose