The impact of mode of delivery and gestational age on cord blood hematopoietic stem/progenitor cells.
Human cord blood has been successfully used as an alternative source of hematopoietic stem cells suitable for transplantation. The aim of this study was to assess the impact of gestational age and the mode of delivery on cord blood hematopoietic stem/progenitor cell characteristics. The mode of delivery does not seem to affect either the replating capacity of hematopoietic progenitors colony-forming unit-granulocyte-macrophage or the cord blood content in CD34(+) cells. The higher percentage of CD34(+) cells in cord blood from preterm deliveries compared to full-term ones indicates that hematopoietic progenitors from preterm cord blood may be suitable for transplantation. These findings should be taken into consideration when selection of cord blood units is required for potential use in transplantation.
Dimitriou
Helen
H
Department of Paediatric Haematology/Oncology, University Hospital of Heraklion, Heraklion, Crete 71110, Greece.
Perdikogianni
Chryssoula
C
Stiakaki
Eftichia
E
Vorgia
Pelagia
P
Hatzidaki
Eleftheria
E
Kalmanti
Maria
M
D018952:Antigens, CD34 / Q000097:blood; D003114:Colony-Forming Units Assay; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D005434:Flow Cytometry; D005865:Gestational Age; D006098:Granulocytes / Q000166:cytology / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D008297:Male; D011247:Pregnancy
D018952:Antigens, CD34