An overview of the genetics of substance use disorders.
Twin, family, and adoption studies show that genetic factors play a significant role in vulnerability to becoming addicted to drugs. Through a combination of genetic approaches, the variant alleles responsible for interindividual differences in susceptibility to addiction are being uncovered.
Albert Einstein College of Medicine, Departments of Medicine and Psychiatry, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Lachman@aecom.yu.edu
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D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D009714:Nucleus Accumbens / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000235:genetics / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000235:genetics* / Q000378:metabolism
C485764:OPRM1 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D017450:Receptors, Opioid, mu; D002394:Catechol O-Methyltransferase; D004298:Dopamine