Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population.
The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible population. For this study, blood samples were collected from 88 patients with post-SARS ON and 52 healthy people. Activated partial thromboplastin time (APTT), protein C (PC), antithrombin III (AT-III), plasminogen activator inhibitor (PAI), activated protein C resistance (APC-R), plasminogen (PLG), von Willebrand's factor(vWF), D-dimer (D-D), fibrinogen (Fib), and homocysteine (HCY) were examined by enzyme-linked immunosorbent assay (ELISA). We noted that blood agents of patients with ON changed obviously. APTT, PC, AT-III, PAI, APC-R, and PLG were significantly different between the two groups. Hypercoagulation and hypofibrinolysis were found in patients with post-SARS ON. Therefore, these examinations can be used to screen a population susceptible to ON. Measurements of APTT, PC, AT-III, PAI, APC-R, and PLG are sensitive blood tests for screening purposes.
Center for Osteonecrosis and Joint Preserving and Reconstruction, Department of Orthopaedic Surgery, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China. sun887@163.com
Wei
W
Sun
Zi-rong
ZR
Li
Zhen-cai
ZC
Shi
Nian-fei
NF
Zhang
Yuan-chun
YC
Zhang
D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D002681:China; D005342:Fibrinolysis; D006801:Humans; D008875:Middle Aged; D010020:Osteonecrosis / Q000097:blood* / Q000209:etiology / Q000821:virology*; D010314:Partial Thromboplastin Time; D015849:Plasminogen Inactivators / Q000494:pharmacology; D045169:Severe Acute Respiratory Syndrome / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator