Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis.
BACKGROUND
Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm, with a high rate of local recurrences.


OBJECTIVE
A series of MAC was analyzed and compared to previously published cases.


METHODS
Seven cases of MAC were identified in the register of the institution. Medical and pathological records were reviewed.


RESULTS
The primary MAC were located on the face in all patients, and 85% were initially misdiagnosed. The mean follow-up duration was 108 months. The recurrence rate was high: 4 patients developed recurrences. In 3 patients, the course of the disease was severe: one of them developed pathologically proven lung metastasis.


CONCLUSIONS
The present study and review of the literature confirm the clinically aggressive evolution of MAC and its rare ability to give rise to metastasis. Long-term clinical follow-ups with imaging investigations are mandatory.
Institut Gustave-Roussy, Villejuif, France.
M
M
Gabillot-Carré
F
F
Weill
G
G
Mamelle
F
F
Kolb
F
F
Boitier
P
P
Petrow
J C
JC
Ortoli
A
A
Margulis
P
P
Souteyrand
S
S
Mercier
A
A
Spatz
P
P
Duvillard
P
P
Validire
M-F
MF
Avril
D000328:Adult; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D018280:Carcinoma, Skin Appendage / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery