Recently mobilized transposons in the human and chimpanzee genomes.
Transposable genetic elements are abundant in the genomes of most organisms, including humans. These endogenous mutagens can alter genes, promote genomic rearrangements, and may help to drive the speciation of organisms. In this study, we identified almost 11,000 transposon copies that are differentially present in the human and chimpanzee genomes. Most of these transposon copies were mobilized after the existence of a common ancestor of humans and chimpanzees, approximately 6 million years ago. Alu, L1, and SVA insertions accounted for >95% of the insertions in both species. Our data indicate that humans have supported higher levels of transposition than have chimpanzees during the past several million years and have amplified different transposon subfamilies. In both species, approximately 34% of the insertions were located within known genes. These insertions represent a form of species-specific genetic variation that may have contributed to the differential evolution of humans and chimpanzees. In addition to providing an initial overview of recently mobilized elements, our collections will be useful for assessing the impact of these insertions on their hosts and for studying the transposition mechanisms of these elements.
Mills
Ryan E
RE
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Bennett
E Andrew
EA
Iskow
Rebecca C
RC
Luttig
Christopher T
CT
Tsui
Circe
C
Pittard
W Stephen
WS
Devine
Scott E
SE
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D004251:DNA Transposable Elements; D016678:Genome; D015894:Genome, Human; D006801:Humans; D002679:Pan troglodytes / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid
D017931:DNA Primers; D004251:DNA Transposable Elements