CED-9 and EGL-1: a duo also regulating mitochondrial network morphology.
In both Caenorhabditis elegans and mammals, Bcl-2 family members control apoptosis. In this issue of Molecular Cell, a paper by Delivani et al. (2006) sheds light on a new role of Bcl-2 family members as regulators of mitochondrial network morphology.
Estaquier
Jérôme
J
Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex 15, France.
Arnoult
Damien
D
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020558:GTP Phosphohydrolases; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; D029742:Caenorhabditis elegans Proteins; C087233:Ced-9 protein, C elegans; C112486:EGL-1 protein, C elegans; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012097:Repressor Proteins; D020558:GTP Phosphohydrolases; C470018:MFN2 protein, human