Zinc(II) and copper(II) complexes of beta-substituted hydroxylporphyrins as tumor photosensitizers.
Novel photosensitizers beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato zinc(II) (Zn(II)P) and beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato copper(II) (Cu(II)P) were synthesized and characterized. Their ability of producing singlet oxygen under irradiation was detected by the measurement of decomposition of 1,3-diphenylisobenzofuran (DPBF). The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. Results showed Zn(II)P having high anti-tumor activity, which presents a promising photosensitizer for photodynamic therapy.
Huang
Qimao
Q
Hubei Key Lab of Novel Reactor & Green Chemical Technology, Wuhan 430073, PR China. huangqim@hotmail.com
Pan
Zhiquan
Z
Wang
Ping
P
Chen
Zhangping
Z
Zhang
Xiaolian
X
Xu
Hansheng
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D006801:Humans; D006900:Hydroxylation; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017967:Zinc Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D017967:Zinc Compounds; D003300:Copper