A review of the clinical use of anti-inflammatory therapies for reperfusion injury in myocardial infarction and stroke: where do we go from here?
A number of prominent studies have been conducted using anti-inflammatory therapies to reduce reperfusion injury in myocardial infarction and stroke. Unfortunately, most strategies have failed. This review summarizes in detail the human studies of anti-inflammatory therapy that have been conducted to date. The potential reasons for treatment failure will be discussed from a non-clinical perspective, as will lessons learned from these studies that might guide the design of future clinical studies in this important area.
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah Medical Center, Salt Lake City 84132, USA. Thomas.Kennedy@hsc.utah.edu
Thomas P
TP
Kennedy
Jakob
J
Vinten-Johansen
D000241:Adenosine / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000628:therapy*; D020521:Stroke / Q000628:therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D014665:Vasodilator Agents; D000241:Adenosine