Developments in antiviral drug design, discovery and development in 2004.
This article summarizes key aspects of progress made during 2004 toward the design, discovery and development of antiviral agents for clinical use. Important developments in the identification, characterization and clinical utility of inhibitors of human immunodeficiency virus; the hepatitis viruses, hepatitis B, hepatitis C; the herpes family of viruses, herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus and human cytomegalovirus; the respiratory viruses, influenza, respiratory syncytial virus, human metapneumovirus, picornaviruses, measles and the severe acute respiratory syndrome coronavirus; human papilloma virus; rotavirus; Ebola virus and West Nile virus, are reviewed.
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA. Nicholas.Meanwell@bms.com
Nicholas A
NA
Meanwell
Makonen
M
Belema
David J
DJ
Carini
Stanley V
SV
D'Andrea
John F
JF
Kadow
Mark
M
Krystal
B Narasimhulu
BN
Naidu
Alicia
A
Regueiro-Ren
Paul M
PM
Scola
Sing-Yuen
SY
Sit
Michael A
MA
Walker
Tao
T
Wang
Kap-Sun
KS
Yeung
D000595:Amino Acid Sequence; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006518:Hepatitis Viruses / Q000187:drug effects*; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D019428:HIV Integrase Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D009705:Nucleosides; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors