Effect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia-reperfusion injuries.
Oxygen-derived free radicals have been implicated in the pathogenesis of tissue injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active ingredient of honeybee propolis, has been identified as having potent antioxidant and anti-inflammatory properties. We evaluated the ability of CAPE applied intraperitoneally in reducing tissue injury after ischaemia-reperfusion. To investigate whether treatment with CAPE modifies the concentrations of the endogenous indices of oxidant stress, we examined its effects on a model of flap ischaemia-reperfusion injury in rats. CAPE (10 micromol/kg) was given through the peritoneum before reperfusion. CAPE given intraperitoneally had an inhibitory effect on tissue injury after ischaemia-reperfusion comparable to that of a control group. The anti-inflammatory and antioxidant properties of CAPE may contribute to its suppression of tissue injury.
Department of Plastic Surgery, Medical Faculty, Inönü University Malatya, Medical School, Turgut Ozal Medical Center, Turkey. btbilen@inonu.edu.tr
Bilge Türk
BT
Bilen
Hidir
H
Kilinç
Nezih
N
Alaybeyoglu
Mehmet
M
Celik
Mustafa
M
Iraz
Nurzen
N
Sezgin
Ahmet
A
Gültek
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D006085:Graft Survival; D008297:Male; D009566:Nitrates / Q000032:analysis; D009573:Nitrites / Q000032:analysis; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000628:therapy*; D013524:Surgical Flaps / Q000098:blood supply*
D000975:Antioxidants; D002109:Caffeic Acids; D009566:Nitrates; D009573:Nitrites; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol