The Ets transcription factors of the PEA3 group: transcriptional regulators in metastasis.
The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis.
de Launoit
Yvan
Y
UMR 8161, Institut de Biologie de Lille, CNRS/Université de Lille I/Université de Lille II/Institut Pasteur de Lille, BP 447, 1 rue Calmette, 59021 Lille Cedex, France. yvan.delaunoit@ibl.fr
Baert
Jean-Luc
JL
Chotteau-Lelievre
Anne
A
Monte
Didier
D
Coutte
Laurent
L
Mauen
Sébastien
S
Firlej
Virginie
V
Degerny
Cindy
C
Verreman
Kathye
K
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors; C065788:transcription factor PEA3