Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus.
We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06-5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00-1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte. dqueiroz@medicina.ufmg.br
Dulciene Maria Magalhães
DM
Queiroz
Andreia Maria Camargos
AM
Rocha
Gifone Aguiar
GA
Rocha
Sarah Maria Singulano
SM
Cinque
Adriana Gonçalves
AG
Oliveira
Alicia
A
Godoy
Hugo
H
Tanno
D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis; D016480:Helicobacter pylori; D019698:Hepatitis C, Chronic / Q000382:microbiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000382:microbiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio