One-pot synthesis in aqueous system for water-soluble chitosan-graft-poly(ethylene glycol) methyl ether.
Chitosan is functionalized with poly(ethylene glycol) methyl ether (mPEG) at the amino and hydroxyl groups via a single step reaction in a homogeneous aqueous system. A chitosan aqueous solution obtained from the mixture of chitosan and hydroxybenzotriazole (HOBt) in water is a key factor in providing mild conditions to conjugate mPEG by using a carbodiimide conjugating agent. The reaction at ambient temperature for 24 h gives chitosan-g-mPEG with water solubility with mPEG content as high as 42%. This work demonstrates that a water-soluble chitosan-HOBt complex is an effective system for the preparation of chitosan derivatives via the aqueous system without the use of acids or organic solvents.
Fangkangwanwong
J
J
The Petroleum and Petrochemical College, Chulalongkorn University,Phya Thai,Bangkok 10330,Thailand.
Akashi
Mitsuru
M
Kida
Toshiyuki
T
Chirachanchai
Suwabun
S
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014230:Triazoles / Q000737:chemistry; D014867:Water
D001672:Biocompatible Materials; D001704:Biopolymers; D014230:Triazoles; D014867:Water; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D048271:Chitosan; C011852:1-hydroxybenzotriazole