A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.
A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN-alpha. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up-regulated by IFN-alpha stimulation, and that it is involved in the regulation of fibroblast growth through the JAK-STAT signalling pathway.
Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming, China.
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LD
Liu
C-H
CH
Dong
H-J
HJ
Shi
H-L
HL
Zhao
L-C
LC
Wang
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SH
Ma
Q-H
QH
Li
D015703:Antigens, CD / Q000737:chemistry*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000737:chemistry*; D001483:Base Sequence; D002460:Cell Line; D049109:Cell Proliferation; D005347:Fibroblasts / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D050832:Interferon-Stimulated Gene Factor 3 / Q000502:physiology; D016898:Interferon-alpha / Q000494:pharmacology*; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D050791:STAT Transcription Factors / Q000502:physiology*; D015398:Signal Transduction; D015854:Up-Regulation; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D050832:Interferon-Stimulated Gene Factor 3; D016898:Interferon-alpha; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D050791:STAT Transcription Factors; D000099192:CD69 Antigens; C104778:CLEC2B protein, human; C079868:gamma interferon activation factor