Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke.
We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. lisa.jacola@cchmc.org
L M
LM
Jacola
M B
MB
Schapiro
V J
VJ
Schmithorst
A W
AW
Byars
R H
RH
Strawsburg
J P
JP
Szaflarski
E
E
Plante
S K
SK
Holland
D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010100:Oxygen / Q000097:blood; D013997:Time Factors; D014705:Verbal Behavior / Q000502:physiology*
D010100:Oxygen