Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents.
Iron nanoparticles, either formed in situ stabilized by 1,6-bis(diphenylphosphino)hexane or polyethylene glycol (PEG), or preformed stabilized by PEG, are excellent catalysts for the cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing beta-hydrogens and they also prove effective in a tandem cyclization/cross-coupling reaction.
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UKBS8 1TS. r.bedford@bristol.ac.uk
Robin B
RB
Bedford
Michael
M
Betham
Duncan W
DW
Bruce
Sean A
SA
Davis
Robert M
RM
Frost
Michael
M
Hird