Evolution of serum lipids and lipoprotein (a) levels in epileptic children treated with carbamazepine, valproic acid, and phenobarbital.
The concentration levels of serum lipids and lipoprotein (a) were measured in 20 children receiving carbamazepine, 25 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment while eating a normal diet, (2) during chronic treatment while eating a low-fat diet (children treated with carbamazepine and phenobarbital with high levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), and (3) 3 months after the end of treatment with antiepileptic drugs. Patients during chronic treatment and eating a normal diet revealed significant changes in lipids, but when we reevaluated the groups of children treated with carbamazepine and phenobarbital when they were eating a low-fat diet and reevaluated the three groups of children 3 months after the end of treatment, a complete return to normal of all parameters was observed. These data demonstrate that the changes induced by these drugs are transient, reversible, and influenced by a low-fat diet. (J Child Neurol 2006;21:48-53).
Departamento de Pediatría, Servicio de Neuropediatría, Universidad de Santiago de Compostela, Spain. pdcastro@usc.es
Manuel
M
Castro-Gago
María Inés
MI
Novo-Rodríguez
Manuel Oscar
MO
Blanco-Barca
Adela
A
Urisarri-Ruíz de Cortázar
Javier
J
Rodríguez-García
Santiago
S
Rodríguez-Segade
Jesús
J
Eirís-Puñal
D000293:Adolescent; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D004032:Diet / Q000379:methods; D004827:Epilepsy / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood* / Q000187:drug effects; D008297:Male; D010634:Phenobarbital / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use*
D000927:Anticonvulsants; D008055:Lipids; D017270:Lipoprotein(a); D002220:Carbamazepine; D014635:Valproic Acid; D010634:Phenobarbital