Amyloidosis and its impact on patients with ESRD.
Patients, like those with ESRD, who have lost the ability to filter excess proteins from their bodies are at risk to develop beta-2-microglobin amyloidosis, also known as dialysis-related amyloidosis (DRA). When the kidneys do not work efficiently, a protein called beta-2-microglobulin can build up in the blood. Eventually, these molecules can form large deposits and potentially damage surrounding tissues. Currently, dialyzer membranes do not effectively remove these large molecules and, as the blood levels become elevated, deposits begin forming in bone, joints, and tendons resulting in pain and/or stiffness. Unfortunately, there is no known cure for DRA, although attempts are being made to develop dialyzer membranes that can more efficiently remove beta-2-microglobulin from the blood. Implications for practice include early diagnosis, patient teaching, optimal pain management and fall risk management.
Renal Care Services, Medical Center of Central Georgia, Macon, USA.
Sandra D
SD
Copeland
D000058:Accidental Falls / Q000517:prevention & control; D000686:Amyloidosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D001706:Biopsy; D055316:Cystatin C; D015891:Cystatins; D042241:Early Diagnosis; D004867:Equipment Design; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D007255:Information Services; D020407:Internet; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008567:Membranes, Artificial; D024802:Nurse's Role; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D010353:Patient Education as Topic; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation; D012307:Risk Factors; D012308:Risk Management; D015996:Survival Rate; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D001613:beta 2-Microglobulin / Q000378:metabolism*
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D008567:Membranes, Artificial; D001613:beta 2-Microglobulin