Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia.
Magnetic resonance imaging (MRI) requires long-lasting immobilization that frequently can only be provided by general anesthesia in pediatric patients. Sevoflurane provides adequate anesthesia but many patients experience emergence agitation. Small doses of ketamine and nalbuphine provide moderate sedation but their benefits have subsided at the time of emergence. We hypothesized that delaying their administration until the end of the procedure would prevent emergence agitation without prolonging patient wake-up and discharge times from the postanesthesia care unit. We performed a double-blind study involving 90 patients (aged 6 mo to 8 yr) randomly allocated to 1 of 3 groups receiving either saline (S-group), ketamine (0.25 mg/kg) (K-group), or nalbuphine (0.1 mg/kg) (N-group) at the end of an MRI procedure under sevoflurane anesthesia. We evaluated emergence conditions, sedation/agitation status and completion of discharge criteria at 30 min. The three groups were comparable in age, sex ratio, physical status, and associated medical disorders. Emergence conditions did not differ significantly. There were significantly more agitated children, at all times, in the S-group and more obtunded patients at early times (5 and 10 min) in both K- and N-groups. All patients met discharge criteria at 30 min but significantly more children were awake and quiet in the K-group and still more in the N-group. In conclusion, small doses of ketamine or nalbuphine administered at the end of an MRI procedure under sevoflurane anesthesia reduce emergence agitation without delaying discharge. Nalbuphine provided better results than ketamine.
Dalens
Bernard J
BJ
Department of Anesthesiology, CHUL du Centre Hospitalier Universitaire de Québec, Sainte-Foy, Québec, Canada. bdalens@videotron.ca
Pinard
Anne Marie
AM
Létourneau
Dany-Roch
DR
Albert
Natalie T
NT
Truchon
René J Y
RJ
D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D016009:Chi-Square Distribution; D006801:Humans; D007223:Infant; D007649:Ketamine / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008738:Methyl Ethers / Q000009:adverse effects*; D009266:Nalbuphine / Q000008:administration & dosage*; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000517:prevention & control*; D000077149:Sevoflurane; D018709:Statistics, Nonparametric; D013997:Time Factors
D008738:Methyl Ethers; D000077149:Sevoflurane; D007649:Ketamine; D009266:Nalbuphine