Sensory nerve excitability and neuropathy in end stage kidney disease.
BACKGROUND
Peripheral neuropathy is present in 65% of patients with end stage kidney disease (ESKD) starting dialysis. Studies of membrane potential and axonal ion channel function may help explain the pathophysiology.


OBJECTIVE
To follow changes in median sensory axon excitability in patients with ESKD treated with haemodialysis, and correlate them with clinical rating scales and serum levels of potential neurotoxins.


METHODS
Sensory nerve action potentials were recorded from the second digit following stimulation of the median nerve in 12 ESKD patients. Stimulus-response behaviour using two stimulus durations, threshold electrotonus to 100 ms polarising currents, a current-threshold relation, and recovery of excitability following supramaximal stimulation were recorded before, during, and after haemodialysis. Serum concentrations of potential neurotoxins were measured.


RESULTS
Before dialysis, there were changes in nerve excitability consistent with axonal depolarisation: refractoriness was increased; superexcitability and depolarising threshold electrotonus were reduced. Following dialysis there were improvements in all indices, with correlations between excitability abnormalities and serum potassium measurements. Neuropathic symptoms correlated with excitability changes.


CONCLUSIONS
Nerves are depolarised before haemodialysis in ESKD patients. The correlation of excitability abnormalities with potassium indicates that the achievement of normokalaemia should be a priority in treating such patients.
Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW 2031, Australia.
A V
AV
Krishnan
R K S
RK
Phoon
B A
BA
Pussell
J A
JA
Charlesworth
M C
MC
Kiernan
D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001369:Axons / Q000378:metabolism; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008475:Median Nerve / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010292:Paresthesia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D006435:Renal Dialysis; D015222:Sodium Channels / Q000378:metabolism
D015222:Sodium Channels; D011188:Potassium