Recent developments in beta-blockers and anaesthesia.
OBJECTIVE
To evaluate developments on the subject of beta-blockers and anaesthesia published in the past 12 months. The administration of beta-blockers has been established as a pharmacological approach to reduce cardiac events in the perioperative period. A number of studies and reviews have been published underlining the appropriateness of this approach in patients undergoing non-cardiac as well as cardiac surgery. A lack of transfer of the scientific knowledge to clinical practice is evident not only in the field of perioperative medicine, which results in an under-use of beta-blockers. Open questions are still directed towards the optimal dosage, the effectiveness of chronic beta-blockade and the effects of beta-blockade in traumatized and burned patients.


RESULTS
Progress in the use of beta-blockers has been realized by the introduction of institutional protocols. In chronic beta-blockade a simple continuation does not provide effective protection. Improved protection might be gained by the combination of beta-blockers and statins in high-risk patients. The role of beta-blockers in pain management is currently a field of interest, although there seem to be many open questions. There are still doubts about the evidence of perioperative beta-blockade: the results of large trials will be published in the next 2 years. The approach is cost-effective: a comparison with other alternative approaches to cardioprotection is pending.


CONCLUSIONS
There has been significant progress in the use of perioperative beta-blockade. Although a considerable amount of knowledge is obvious, the optimal strategy in different clinical settings is still a matter of debate.
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, UKM Münster, Germany. a.meissner@uni-muenster.de
Andreas
A
Meissner