[Study of cellular electrophysiology based on Noble98 dynamic model of ventricular action potential].
On the basis of mammalian ventricular action potential model Noble98, and with the use of Runge-Kutta for solution, the Wenckebach periodicity phenomenon, the transmural heterogeneity of the ventricular myocardium and its rate dependence are studied. The results indicate that these inherent properties may, lead to temporal-space disorganized in the normal heart,and may become the underlying factors for arrhythmias. At the same time, in this study are established the basic methods for quantitative cellular electrophysiology which is essential for future studies on the mechanism of arrhythmia.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education of China, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. maxr@263.net
Hong
H
Zhang
Lin
L
Yang
Yinbin
Y
Jin
Zhenxi
Z
Zhang
Yizhuo
Y
Huang
D000200:Action Potentials / Q000502:physiology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003198:Computer Simulation; D004594:Electrophysiology; D006329:Heart Conduction System / Q000502:physiology; D006352:Heart Ventricles; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*
D007473:Ion Channels