Microarray analysis of the osmotic stress response in Pseudomonas aeruginosa.
Transcriptional profiling of Pseudomonas aeruginosa grown under steady-state hyperosmotic stress conditions showed an up-regulation of genes associated with osmoprotectant synthesis, putative hydrophilins, and the type III secretion system with associated cytotoxins. A large number of regulatory genes, including several two-component systems not previously known to be influenced by osmolarity, were differentially expressed by P. aeruginosa in immediate response to hyperosmotic shock.
School of Allied Health Sciences, Southwestern Oklahoma State University, Weatherford, OK 73096, USA. arden.aspedon@swosu.edu
Arden
A
Aspedon
Kelli
K
Palmer
Marvin
M
Whiteley
D001426:Bacterial Proteins / Q000235:genetics*; D001622:Betaine; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D009994:Osmolar Concentration; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors
D001426:Bacterial Proteins; D001622:Betaine