Successful treatment of delusions of parasitosis with olanzapine.
BACKGROUND
Delusional parasitosis is a rare disorder in which patients have a fixed, false belief of being infested with parasites. It is often accompanied by a refusal to seek psychiatric care. Delusions of parasitosis is classically treated with typical antipsychotic agents, the traditional dermatologic choice being pimozide. However, pimozide's adverse effect profile and the need for frequent electrocardiographic monitoring make such treatment less practical.


METHODS
We describe 3 patients who were diagnosed as having delusional parasitosis that was successfully treated with a recently Food and Drug Administration-approved atypical antipsychotic agent, olanzapine (5 mg/d). Olanzapine has a more benign adverse effect profile than typical antipsychotic agents and eliminates the need for electrocardiographic monitoring. Olanzapine therapy has been associated with such adverse effects as sedation, hyperlipidemia, weight gain, and insulin resistance, all of which were infrequent in our patients.


CONCLUSIONS
Olanzapine is an atypical antipsychotic agent that can be used as a first-line agent in delusional parasitosis as a safer therapeutic option without a specialized monitoring regimen.
Meehan
William J
WJ
Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Badreshia
Sonia
S
Mackley
Christine L
CL
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003702:Delusions / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010272:Parasitic Diseases / Q000523:psychology*; D010868:Pimozide / Q000627:therapeutic use
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010868:Pimozide; D000077152:Olanzapine