Latex allergy in children: a follow-up study.
BACKGROUND
Natural rubber latex allergy is an important health problem. Multiple contacts with latex in childhood are a risk factor. Many aspects of this disease are still unknown, one of which is the clinical outcome of these children. The aim of this study was to evaluate the clinical and epidemiological features of latex allergy and compliance with latex avoidance instructions in allergic children.


METHODS
Seventeen consecutive patients with a history of latex allergy, fruit allergy or chronic urticaria were selected. The patients underwent a skin prick test and determination of specific-IgE to latex at the start and at end of the study (median follow-up: 3 years). At diagnosis, patients with a positive result to one of the tests and a clinical history of latex allergy were considered allergic; patients with a positive test but without a clinical history suggestive of allergy were considered sensitized. These children were given latex avoidance instructions.


RESULTS
Eleven children (64.7 %) were classified as allergic and 6 (35.3 %) as sensitized. Five patients had undergone latex-free surgery after diagnosis without incident. During follow-up, 11 patients (8 allergic and 3 sensitized) had contact with latex. Contact occurred in the home in 10 children, and all were symptomatic. Specific-IgE levels to latex at the end of the study were significantly higher in patients who had contact with latex during the follow-up period than in those without latex contact.


CONCLUSIONS
Strict compliance with latex avoidance instructions is essential both inside and outside the hospital. Greater emphasis should be placed on reducing latex exposure in the home and school environments, as such contact could maintain positive IgE-antibody levels.
Servicio de Alergología, Hospital Ramón y Cajal, Madrid, Spain.
M C
MC
Diéguez Pastor
M
M
Antón Girones
R
R
Blanco
Z
Z
Pulido
A
A
Muriel
B
B
de la Hoz Caballer
D000293:Adolescent; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D003876:Dermatitis, Atopic / Q000453:epidemiology; D004781:Environmental Exposure; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D005638:Fruit / Q000009:adverse effects; D006794:Household Articles; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D020315:Latex Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D012130:Respiratory Hypersensitivity / Q000453:epidemiology; D012882:Skin Tests; D013030:Spain / Q000453:epidemiology; D016135:Spinal Dysraphism / Q000150:complications; D014581:Urticaria / Q000453:epidemiology / Q000209:etiology
D007073:Immunoglobulin E