[Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
Metabolic syndrome (MS) is a worldwide medical problem characterized by a cluster of cardiovascular risk factors and metabolic modifications involving peripheral insulin resistance. Nonalcoholic steatohepatitis (NASH) represents the liver expression of this pathological condition. Both MS and NASH are characterized by proinflammatory status and increased oxidative stress. According this, we aimed to review the literature for considering a possible role for vitamins as therapeutical support in MS and NASH.
Istituto di Medicina Interna e Geriatria, Policlinico Gemelli, Università Cattolica del Sacro Cuore, Roma.
Luca
L
Miele
Maria L
ML
Gabrieli
Alessandra
A
Forgione
Vittoria
V
Vero
Antonella
A
Gallo
Esmeralda
E
Capristo
Giovanni
G
Gasbarrini
Antonio
A
Grieco
D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006505:Hepatitis / Q000150:complications / Q000378:metabolism*; D006710:Homocysteine / Q000494:pharmacology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D012307:Risk Factors; D000077385:Silybin; D012838:Silymarin / Q000627:therapeutic use; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D012838:Silymarin; D014815:Vitamins; D006710:Homocysteine; D014807:Vitamin D; D000077385:Silybin; D005492:Folic Acid; D014805:Vitamin B 12