Sepsis: emerging role of nitric oxide and selectins.
Sepsis--a state of systemic bacterial infection--often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment. Many of the ill effects of sepsis are attributed to an abnormally enhanced host inflammatory response that leads to neutrophil recruitment and activation involving selectins, a class of adhesion molecules, in the initial stages. Nitric oxide and its various isoforms have also been implicated in various vascular alterations and directly participate in the cellular toxicity in sepsis. This review briefly describes the role of selectins and nitric oxide in experimental and clinical sepsis as well as the therapeutic outcomes of blocking therapies.
Chandra
Abhijit
A
Department of Surgery, King George Medical University--Lucknow, India.
Enkhbaatar
Perenlei
P
Nakano
Yoshimitshu
Y
Traber
Lillian D
LD
Traber
Daniel L
DL
D000818:Animals; D006801:Humans; D018375:Neutrophil Activation / Q000276:immunology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000502:physiology*; D019087:Selectins / Q000276:immunology / Q000502:physiology*; D018805:Sepsis / Q000276:immunology*
D019087:Selectins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase