PlasmaKinetic Superpulse transurethral resection versus conventional transurethral resection of prostate.
OBJECTIVE
To compare the efficacy and safety of the PlasmaKinetic (PK) Superpulse system with that of conventional transurethral resection of the prostate (TURP) in terms of restoration of urinary flow and early postoperative course.


METHODS
One hundred five men older than 45 years with lower-urinary tract symptoms associated with benign prostatic hyperplasia (BPH) were randomized, 51 undergoing standard TURP with glycine as the irrigation fluid and 53 TURP with the PK Superpulse system with normal saline as irrigant. The operative time, intraoperative blood loss, catheter time, change in serum electrolytes (particularly sodium), and uroflowmetry and American Urological Association (AUA) Symptom Scores were compared.


RESULTS
The blood loss as well as the catheter time observed in the PK Superpulse arm were significantly less than those in the conventional-TURP arm. The mortality rate was 0 in both the arms. The mean operative time was less in the PK Superpulse arm, although not significantly so. Hyponatremia was statistically insignificant. Significant changes were observed in the AUA Scores in both arms.


CONCLUSIONS
The PK Superpulse system provides faster removal of tissue in a bloodless field with better views and a safer environment of saline irrigation with efficacy comparable to that of conventional TURP. However, further randomized trials with extended follow-up may be needed to better define the role of the PK Superpulse system in treating patients with symptomatic BPH.
Institute of Urology and Department of Surgery, B.J. Medical College and Sassoon General Hospital, Pune, India. suresh_iou@yahoo.com
Suresh
S
Patankar
Arun
A
Jamkar
Satyen
S
Dobhada
Vaibhav
V
Gorde
D000368:Aged; D016063:Blood Loss, Surgical; D005500:Follow-Up Studies; D005998:Glycine / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000503:physiopathology; D011182:Postoperative Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D011336:Probability; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000601:surgery*; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D007507:Therapeutic Irrigation / Q000295:instrumentation*; D020728:Transurethral Resection of Prostate / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D014546:Urinary Catheterization; D014835:Volatilization
D005998:Glycine