Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats.
OBJECTIVE
To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats.


METHODS
Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis.


RESULTS
Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde.


CONCLUSIONS
Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
Jung
Tae Woo
TW
The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Lee
Ji Young
JY
Shim
Wan Sub
WS
Kang
Eun Seok
ES
Kim
Soo Kyung
SK
Ahn
Chul Woo
CW
Lee
Hyun Chul
HC
Cha
Bong Soo
BS
D000818:Animals; D015153:Blotting, Western; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000097:blood; D003484:Cyanamide / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015151:Immunoblotting; D007398:Interpersonal Relations; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077154:Rosiglitazone; D012919:Social Behavior; D045162:Thiazolidinediones / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
D002492:Central Nervous System Depressants; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000431:Ethanol; D003484:Cyanamide