Inhibitory effect of cinnamoyl compounds against human malignant cell line.
In the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (CMN), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. CMN inhibited the proliferation of K562 leukemic cells by induction of apoptosis. The current study demonstrated synergy with combination of drug therapy, and suggested that combination of ferulic acid and cisplatin synergistically inhibited cellular proliferation. Cytotoxic synergy was observed independent of the sequence of addition of two drugs to cultured cells. The synergized growth inhibitory effect with cisplatin was probably associated with G2-M arrest in cell cycle progression. These findings suggested that among the cinnamoyl compounds, CMN was most potent and FER appeared to be a better modulating agent on human malignant cell line.
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Chemotherapy Group, Khanolkar Shodhika, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India.
Radhika
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Motiwale
Leena
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Rao
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D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols
D000970:Antineoplastic Agents; D003505:Cyclodextrins; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D003474:Curcumin; D002945:Cisplatin