Benzopyrans, biphenyls and xanthones from the root of Garcinia linii and their activity against Mycobacterium tuberculosis.
A new benzopyran, (S)-3-hydroxygarcibenzopyran, and three new biphenyls, garcibiphenyl C, garcibiphenyl D, garcibiphenyl E, together with thirteen known compounds have been additionally isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses. Among the isolates, 1,7-dihydroxy-3-methoxyxanthone and 1,5-dihydroxy-3-methoxyxanthone showed antitubercular activities with MICs of 3.1 +/- 0.5 and 6.3 +/- 1.0 microg/mL against Mycobacterium tuberculosis 90-221,387 in vitro, respectively.
Department of Pharmacy, Tajen University, Pingtung, Taiwan, People's Republic of China. jjchen@mail.tajen.edu.tw
Jih-Jung
JJ
Chen
Chien-Fang
CF
Peng
Hung-Yi
HY
Huang
Ih-Sheng
IS
Chen
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001578:Benzopyrans / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D029760:Garcinia; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D044004:Xanthones / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D001713:Biphenyl Compounds; D010936:Plant Extracts; D044004:Xanthones