Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis.
BACKGROUND
Plasma adiponectin levels increase after the administration of glimepiride. This unique effects would also be expected to improve other adipocytokines and have anti-atherosclerotic action in patients with metabolic syndrome.


METHODS
Thirty-four patients with type 2 diabetes mellitus who were administrated glibenclamide were randomly divided into two groups. In 20 patients glibenclamide was changed to glimepiride (GP group), and the administration of glibenclamide (GB group) was continued in 14 patients. Twelve patients receiving insulin therapy (INS group) were enrolled for comparison. The levels of plasma adiponectin, high sensitive-CRP, TNF-alpha, interleukin-6, homeostasis model assessment-insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) were measured before and 28 weeks after the therapy.


RESULTS
HOMA-IR in the GP group was significantly decreased compared to the GB group. Plasma adiponectin levels were significantly increased in the GP group but not in the other groups. TNF-alpha, interleukin-6 and high sensitive-CRP levels were significantly decreased in the GP group, but not in the other groups. The baPWV and AI levels did not change in either the GB or the INS group, but were significantly decreased in the GP group.


CONCLUSIONS
Glimepiride appears to improve insulin resistance and atherosclerotic disorders.
Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School, Japan.
Kunihiko
K
Koshiba
Masahiro
M
Nomura
Yutaka
Y
Nakaya
Susumu
S
Ito
D017667:Adipocytes / Q000187:drug effects; D000368:Aged; D050197:Atherosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*
D016207:Cytokines; D007004:Hypoglycemic Agents; D018836:Inflammation Mediators; D013453:Sulfonylurea Compounds; C057619:glimepiride; D005905:Glyburide