Frequency of common MDR1 gene variants in a Polish population.
P-glycoprotein (P-gp) is a transmembrane transporter playing an important role in drug efflux. There is growing evidence that P-gp activity may be related to haplotypes of MDR1 gene. In the current study, the frequencies of common functional polymorphisms in MDR1 gene (2677G > A,T and 3435C > T) were evaluated using PCR-RFLP and allele-specific amplification, in a group of 204 healthy individuals of Caucasian origin from Poland. It was found that the frequencies of the studied single nucleotide polymorphisms were similar to those reported for other Caucasian populations, and were as follows: 2677G-3435C--0.453, 2677G-3435T--0.143, 2677T-3435C--0.015, 2677T-3435T--0.370, 2677A-3435C--0.008, 2677A-3435T--0.011. The results of our study may give the basis for predicting pharmacokinetic and pharmacodynamic effects of many commonly used drugs in the Polish population.
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp. 72, PL 70-111 Szczecin, Poland.
Mateusz
M
Kurzawski
Andrzej
A
Pawlik
Wanda
W
Górnik
Marek
M
Droździk
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D019450:Genes, MDR; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010597:Pharmacogenetics; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D044465:White People
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1