Effect of aqueous extract of Tragia involucrata Linn. on acute and subacute inflammation.
Antiinflammatory activity of aqueous extract of Tragia involucrata was tested on carrageenan-induced hind paw oedema and cotton pellet granuloma models in albino rats. In the subacute model, cotton pellet granuloma was produced by implantation of 10 mg sterile cotton in the axilla under ether anaesthesia. The animals were administered an aqueous extract at various concentrations of 50, 100, 200, 300 and 400 mg/kg. Phenyl butazone (80 mg/kg) was used as a standard drug. The paw diameter was measured at different time intervals and the dry granuloma weight was taken after the treatment. The aqueous leaf extract (400 mg/kg) showed the maximum inhibition (84.23%) of oedema at the end of 3 h following carrageenin-induced rat paw oedema. In subacute inflammation, the extract showed 76.25% reduction in granuloma weight. The results prove that the aqueous leaf extract showed highest antiinflammatory activity in acute and subacute inflammation and also support the usage of traditional claims.
Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Ramar Perumal
RP
Samy
Ponnampalam
P
Gopalakrishnakone
Peter
P
Houghton
Maung Maung
MM
Thwin
Savarimuthu
S
Ignacimuthu
D000818:Animals; D002351:Carrageenan; D019665:Euphorbiaceae; D005260:Female; D005549:Foreign-Body Reaction; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D002351:Carrageenan