[Development of antisense nucleotides for therapy].
Antisense oligonucleotides (ASODN) for therapy is a genetic technology which is based on the base-complementary principle. DNA or RNA sequence synthesized by biotechnology is transferred into the target cells to form mRNA-DNA or mRNA-RNA double strand for inhibiting the expression of target genes. In this way we can control and treat some diseases. The development of antisense oligonucleotides drugs has opened a new area of genetic pharmacology. This paper reviews its classifications, mechanics and its wide application in the treatment of viral infection, tumor and cardiovascular diseases. At the same time we pose the problems that need solving.
Wang
Ju
J
Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China. wangju_86@163.com
Wang
Lei
L
Wang
Youde
Y
D001157:Arterial Occlusive Diseases / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology / Q000627:therapeutic use*; D014777:Virus Diseases / Q000628:therapy*
D016376:Oligonucleotides, Antisense