Structure and dynamics of macrophage podosomes.
Podosomes are short-lived, dynamic actin-rich adhesions classically formed in macrophages, osteoclasts and Src-transformed fibroblasts. Though related to the more commonly studied focal adhesions, sharing several structural and regulatory proteins, podosomes have distinct functional, structural, and dynamic characteristics. Here, we discuss current understanding of the function of podosomes in disparate cell types and how this relates to their structure and dynamics.
Evans
James G
JG
Whitehead MIT BioImaging Center, Computational and Systems Biology Initiative, Massachusetts Institute of Technology, MA 02139, USA. jgevans@wi.mit.edu
Matsudaira
Paul
P
D008841:Actin Cytoskeleton / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000502:physiology / Q000648:ultrastructure