Advances in male hormonal contraception.
There is a need to develop new contraceptives, particularly for men whose current choices are suboptimal in terms of effectiveness and ease of reversibility. Recent surveys indicate that men and their partners would be willing to rely on male hormonal contraceptives. Male hormonal contraception works by reversibly suppressing sperm production. Testosterone in combination with progestins or gonadotropin-releasing hormone antagonists induces profound and consistent sperm suppression. Asian men are more susceptible to the suppressive effects of testosterone given alone, even if they may benefit from the addition of an adjunctive agent to obtain optimal contraceptive protection. The aim of this review is to comment on the recent relevant achievements in the field.
Meriggiola
Maria Cristina
MC
I Clinic of Obstetrics and Gynecology, University of Bologna, Bologna, Italy. cristina.meriggiola@unibo.it
Pelusi
Giuseppe
G
D000818:Animals; D000988:Antispermatogenic Agents / Q000737:chemistry / Q000494:pharmacology; D003267:Contraception / Q000379:methods / Q000639:trends*; D003272:Contraceptive Agents, Male / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006727:Hormone Antagonists / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends
D000988:Antispermatogenic Agents; D003272:Contraceptive Agents, Male; D006727:Hormone Antagonists