Effects of two different oral contraceptives on total body water: a randomized study.
OBJECTIVE
This open-label, randomized study evaluated the effect of two different oral contraceptives on body weight and composition during one cycle of treatment.


METHODS
Eighty women (mean age, 24.6 years) were randomized into three groups and given one of the following contraceptive methods: ethinylestradiol 15 mug/gestodene 60 mug (EE/GST, n=25), ethinylestradiol 30 mug/drospirenone 3 mg (EE/DRS, n=29) or male condom (control group, n=26). Bioelectric impedance analysis (BIA) was carried out on the first, 10th and 21st days during the use of oral contraceptives or in the menstrual cycle (control group), and total body water (TBW), fat mass (FM) and fat-free mass (FFM) were measured.


RESULTS
No significant variations in TBW, FM or FFM were observed in the three groups during the cycle. Intergroup analysis showed no differences in TBW or FM; however, users of EE/GST showed a statistically significant increase in FFM compared to the control group.


CONCLUSIONS
The different doses of ethinylestradiol associated with gestodene or drospirenone showed no statistically significant effects on TBW or FM during one cycle of observation.
Department of Gynecology and Obstetrics, Faculty of Medicine of Jundiaí, Jundiaí, São Paulo 13201-789, Brazil. rogeriobonassi@terra.com.br
Rogério Bonassi
RB
Machado
Fabrício
F
Tachotti
Glauce
G
Cavenague
Edna
E
Maia
D000328:Adult; D000736:Androstenes / Q000008:administration & dosage*; D001823:Body Composition / Q000187:drug effects; D001834:Body Water / Q000187:drug effects*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D017097:Electric Impedance; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage*; D011446:Prospective Studies
D000736:Androstenes; D003276:Contraceptives, Oral; D009652:Norpregnenes; C033273:Gestodene; D004997:Ethinyl Estradiol; C035144:drospirenone