Programmable implants--from pulsatile to controlled release.
The aim of this study was to develop programmable implants with a reproducible delayed onset of release followed by several weeks of controlled release. For this purpose, a drug-loaded core was embedded into a drug-free bulk-eroding poly(D,L lactic-co-glycolic acid) or poly(D,L lactic acid) mantle. The manufacturing procedure was established and optimized for three mantle materials, which showed delay times ranging from 7 to 83 days. Triglycerides with fatty acid chain lengths from C12 to C18 were investigated as core materials, producing release periods from 2 to 16 weeks. Concomitantly, applying a convolution/deconvolution model showed the possibility of theoretical prediction of the resulting release profiles.
Department of Pharmaceutical Technology, University of Regensburg, Universitätsstrasse 31, D-93040 Regensburg, Germany.
C
C
Guse
S
S
Koennings
T
T
Blunk
J
J
Siepmann
A
A
Goepferich
D001190:Arylsulfonates / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry; D004343:Drug Implants; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry; D008956:Models, Chemical; D008962:Models, Theoretical; D011091:Polyesters; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014280:Triglycerides / Q000737:chemistry
D001190:Arylsulfonates; D004343:Drug Implants; D011091:Polyesters; D011108:Polymers; D014280:Triglycerides; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D002784:Cholesterol; C005047:pyranine