Endothelium-independent relaxation of aorta rings by two stilbenoids from the orchids Scaphyglottis livida.
Gigantol (1) and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2) from the orchid Scaphyglottis livida induced a significant concentration-dependent relaxation of the contractions evoked by noradrenaline (NA) in endothelium-intact and denuded rat aorta rings. Incubation with N(G)-nitro-L-arginine methyl ester (L-NAME, 1x10(-5) M) or methylene blue (MB, 1x10(-7) M) significantly reduced the relaxation induced by the stilbenoids 1 and 2. The results suggested that two or more mechanisms are involved in the vasorelaxant effects of both compounds.
Estrada-Soto
S
S
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México, D. F., 04510, México.
López-Guerrero
J J
JJ
Villalobos-Molina
R
R
Mata
R
R
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001632:Bibenzyls; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008519:Medicine, Traditional; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
C511111:3,7-dihydroxy-2,4-dimethoxyphenanthrene; D001632:Bibenzyls; D010616:Phenanthrenes; D013267:Stilbenes; D014665:Vasodilator Agents; C478099:gigantol; D006139:Guaiacol; D012964:Sodium