Papillary carcinoma of the breast in a male patient with a treated prostatic carcinoma diagnosed by fine-needle aspiration biopsy: a case report and review of the literature.
Papillary carcinoma of the male breast is very rare. In this case report, we describe the cytologic, histologic, immunohistochemical, and radiological findings of a papillary carcinoma of male breast. A 67-yr-old man, who had a previous history of prostatic adenocarcinoma, presented with a retroareolar painless mass. There was no known history of breast cancer in his family. A fine-needle aspiration biopsy (FNAB) was performed. Cytological examination revealed a cellular aspirate with three-dimensional papillary clusters. A diagnosis of papillary lesion favoring papillary carcinoma was rendered. Immunohistochemical staining of the cell-block of the FNAB revealed the presence of mammaglobin, and the absence of prostatic specific antigen. The patient underwent lumpectomy, which showed a moderately differentiated infiltrating papillary carcinoma with adjacent areas of ductal carcinoma in situ. FNAB is a useful technique in identifying male breast carcinoma. In conjunction with ancillary studies, this procedure can effectively differentiate between a primary versus metastatic lesion.
Department of Pathology, University of Florida Health Science Center, Jacksonville, Florida 32209, USA. khalbuss@yahoo.com
Walid E
WE
Khalbuss
Abiy
A
Ambaye
Steve
S
Goodison
Asif
A
Loya
Shahla
S
Masood
D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000368:Aged; D044963:Biopsy, Fine-Needle; D018567:Breast Neoplasms, Male / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D060785:Mammaglobin A; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*; D014598:Uteroglobin / Q000032:analysis
D060785:Mammaglobin A; D009363:Neoplasm Proteins; C556448:SCGB2A2 protein, human; D014598:Uteroglobin; D017430:Prostate-Specific Antigen