Bacteriological agents of neonatal sepsis in NICU at Nishtar Hospital Multan.
OBJECTIVE
To find clinical features and bacteriological agents of neonatal sepsis and to determine their antibiotic sensitivity pattern.


METHODS
An observational study.


METHODS
Paediatric Medicine Unit II, Nishtar Hospital, Multan, from July 2003 to January 2004.


METHODS
Neonates admitted with, or clinically suspected to develop neonatal sepsis during their hospital stay, for another reason, were included in this study. Common clinical features were noted and blood culture reports were analyzed for etiological microorganisms and their antibiotic sensitivity pattern.


RESULTS
Among the total 115 cases of clinically suspected neonatal sepsis, 62 (54%) had culture proven sepsis. Out of these 26(42%) presented as early onset sepsis and 36(58%) as late-onset sepsis. Among the bacteriological isolates, gram negative organisms (58%) were slightly more common in both early-onset and late-onset sepsis. Among the Gram-negative isolates E.coli (37%) was the commonest organism followed by Klebsiella (9.6%). Among the gram +ve organisms Staphylococcus aureus (32%) was most frequent. All the microorganisms were resistant to ampicillin. E.coli were mostly sensitive to ceftriaxone(75%), ceftazidime (78%), meropenem (88%), imipenem (80%), and ciprofloxacin (52%). Staphylococcus aureus were more sensitive to ciprofloxacin (85%), meropenem (87%), imipenem (82%) as compared to cephalosporins and aminoglycosides.


CONCLUSIONS
E.coli and Staph. aureus are the most common organisms causing neonatal sepsis and there is high degree of resistance to commonly used first line antibiotics.
Department of Paediatric Medicine Unit-II, Nishtar Hospital, Multan. rushda_aftab@yahoo.com
Rushda
R
Aftab
Imran
I
Iqbal
D000367:Age Factors; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D018805:Sepsis / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000667:Ampicillin