Effect of HCV infection on hepatic fibrosis in patients of thalassaemia major.
OBJECTIVE
To investigate the effect of HCV infection on hepatic fibrosis in patients of thalassaemia major with iron overload in order to modify Pesaro criteria for classification into prognostic groups for allogenic haemopoietic stem cell transplant in these patients.


METHODS
Cross-sectional comparative study.


METHODS
Armed Forces Institute of Pathology, Armed Forces Bone Marrow Transplant Center and Departments of Pediatrics of Military Hospital and Combined Military Hospital, Rawalpindi, from July 2003 to June 2004.


METHODS
Twenty-eight HCV- and 18 HCV+ patients of thalassaemia major, who were prospective recipients of allogeneic bone marrow transplant, were included in the study. Serum ferritin was estimated by chemiluminescent immunoassay. Degree of fibrosis in liver biopsy was scored using Knodell s scoring system. Correlation between the two was evaluated statistically through Pearson s correlation coefficient.


RESULTS
Mean serum ferritin was lower and degree of hepatic fibrosis was less in hepatitis C negative patients of TM. The correlation between serum ferritin and the degree of hepatic fibrosis was much stronger in hepatitis C negative patients with r value of 0.507 and p value of 0.006, which was statistically significant.


CONCLUSIONS
A strong correlation between serum ferritin and degree of hepatic fibrosis was observed in patients of thalassaemia major not infected with hepatitis C infection. Serum ferritin levels alone are, therefore, not sufficient to assess degree of fibrosis in HCV positive patients of TM.
Anwar
Masood
M
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi. masoodanwar_47@hotmail.com
Nadeem
Ali
A
Jamal
Shahid
S
Dilawar
Muhammad
M
Ali
Waqar
W
Aziz
Shahid
S
Ayyub
Muhammad
M
Ahmed
Pervez
P
Ashraf
Tanveer
T
Khan
Badshah
B
Hussain
Tasawwar
T
Hussain
Shujaat
S
D000293:Adolescent; D001706:Biopsy; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D005293:Ferritins / Q000097:blood; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007118:Immunoassay; D007223:Infant; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D017086:beta-Thalassemia / Q000097:blood / Q000150:complications* / Q000628:therapy*
D005293:Ferritins