Relevance of image fusion with MRI for the interpretation of I-123 iodo-methyl-tyrosine scans in patients with suspected recurrent or residual brain tumor.
OBJECTIVE
The aim of the study was to investigate the impact of MR/SPECT image fusion on the interpretation of I-123 iodo-methyl-tyrosine (IMT) SPECT examinations in patients with pretreated brain tumors.


METHODS
In this retrospective study, 45 consecutive patients with suspected recurrent/residual gliomas (n = 41) or cerebral metastases (n = 4) were included. SPECT studies were performed using a triple-head gamma-camera system 10 minutes after injection of 300 to 370 MBq (8.1-10 mCi) I-123 IMT. Concerning MR, T1-, T2-, and FLAIR-weighted sequences as well as contrast-enhanced T1-weighted sequences were acquired by 1.5-T or 3.0-T scanners. For image fusion, the MPI-tool software package was used. SPECT and MR/SPECT fusion images were anonymized and then independently evaluated by 3 observers aware of the clinical data. Tumor localization and extent were evaluated and correlated with histopathology or clinical follow up, including MR imaging.


RESULTS
In 10 of 45 (22%) patients, image fusion had a significant impact on the interpretation of scans: 5 suspected SPECT findings were correctly classified as physiological or therapy-related; in another 5 patients, image fusion added relevant clinical information on tumor extent (infiltration of the contralateral hemisphere n = 3, infiltration of the brain stem n = 2).


CONCLUSIONS
According to our data, image fusion is crucial for the interpretation of positive I-123 IMT SPECT findings.
Department of Radiology, Campus Virchow-Klinikum, University Clinic Charité, Berlin, Germany. h.amthauer@charite.de
Holger
H
Amthauer
Reinhard
R
Wurm
David
D
Kuczer
Juri
J
Ruf
Roger
R
Michel
Julia
J
Eisenacher
Florian
F
Stockhammer
Timm
T
Denecke
Roland
R
Felix
Michail
M
Plotkin
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008781:Methyltyrosines; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon
D003287:Contrast Media; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; C030855:3-iodo-alpha-methyltyrosine