N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat.
We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension. Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 +/- 1 to 131 +/- 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 +/- 2 to 120 +/- 2 mmHg, p < 0.001) but less than ACTH alone (p' < 0.05). In the reversal study, NAC had no significant effect (132 +/- 4 to 124 +/- 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.
Mondo
Charles K
CK
Institute of Cardiology, 2nd Hospital, Tianjin Medical University, Tianjin, PR China.
Zhang
Yi
Y
de Macedo Possamai
Vinicius
V
Miao
Yuchun
Y
Schyvens
Christopher G
CG
McKenzie
Katja U S
KU
Hu
Lexian
L
Guo
Zhijun
Z
Whitworth
Judith A
JA
D000111:Acetylcysteine / Q000627:therapeutic use*; D000324:Adrenocorticotropic Hormone / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
D016166:Free Radical Scavengers; D000324:Adrenocorticotropic Hormone; D000111:Acetylcysteine