Self-reported paranoia during laboratory "binge" cocaine self-administration in humans.
Cocaine-induced paranoia (CIP) has been extensively studied by retrospective interviews; however, only limited efforts have been made to further characterize CIP by human laboratory methods. We examined CIP in 28 healthy cocaine-dependent volunteers, who participated in 2-h, intravenous cocaine self-administration sessions at 8, 16, and 32 mg/70 kg doses, including 18 in a placebo-controlled design. Self-reports of paranoia showed significant main effects of cocaine dose (p=0.0002) and time (p=0.0003), and were statistically distinguishable from placebo at the two highest doses (16 and 32 mg). These effects were accounted for by a subgroup of vulnerable subjects in whom self-reports were consistent across dose and test-retest sessions. Subjects with CIP did not differ from those without CIP with respect to demographic, cocaine use, or cocaine self-administration variables. In conclusion, self-reports of CIP in the human lab are frequently endorsed, dose-dependent, and though variable between subjects, reproducible within subjects. Such methods may facilitate our understanding of the vulnerability to CIP in humans.
Kalayasiri
Rasmon
R
Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA.
Sughondhabirom
Atapol
A
Gueorguieva
Ralitza
R
Coric
Vladimir
V
Lynch
Wendy J
WJ
Morgan
Peter T
PT
Cubells
Joseph F
JF
Malison
Robert T
RT
D000293:Adolescent; D000328:Adult; D003042:Cocaine / Q000008:administration & dosage*; D006801:Humans; D007276:Injections, Intraventricular; D008875:Middle Aged; D009042:Motivation; D010147:Pain Measurement; D010259:Paranoid Disorders / Q000139:chemically induced*; D010919:Placebos; D012646:Self Administration; D012647:Self-Assessment
D010919:Placebos; D003042:Cocaine