Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.
Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland. anne.koivisto@kuh.fi
Anne M
AM
Koivisto
Seppo
S
Helisalmi
Jussi
J
Pihlajamäki
Leena
L
Moilanen
Johanna
J
Kuusisto
Markku
M
Laakso
Mikko
M
Hiltunen
Koivisto
K
Keijo
Tuomo
T
Hänninen
Eeva-Liisa
EL
Helkala
Kari
K
Kervinen
Y Antero
YA
Kesäniemi
Hilkka
H
Soininen
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005387:Finland; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015850:Interleukin-6