One-year outcomes of a randomized clinical trial treating depression in low-income minority women.
This study examines 1-year depressive symptom and functional outcomes of 267 predominantly lowincome, young minority women randomly assigned to antidepressant medication, group or individual cognitive- behavioral therapy (CBT), or community referral. Seventy-six percent assigned to medications received 9 or more weeks of guideline-concordant doses of medications; 36% assigned to psychotherapy received 6 or more CBT sessions. Intent-to-treat, repeated measures analyses revealed that medication (p=.001) and CBT (p=.02) were superior to community referral in lowering depressive symptoms across 1-year follow-up. At Month 12, 50.9% assigned to antidepressants, 56.9% assigned to CBT, and 37.1% assigned to community referral were no longer clinically depressed. These findings suggest that both antidepressant medications and CBT result in clinically significant decreases in depression for low-income minority women.
Health Services Research Center, Neuropsychiatric Institute, University of California, Los Angeles, CA 90024-6505, USA. JMMiranda@mednet.ucla.edu
Jeanne
J
Miranda
Bonnie L
BL
Green
Janice L
JL
Krupnick
Joyce
J
Chung
Juned
J
Siddique
Tom
T
Belin
Dennis
D
Revicki
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage*; D016642:Bupropion / Q000008:administration & dosage*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008913:Minority Groups / Q000523:psychology*; D017374:Paroxetine / Q000008:administration & dosage*; D010353:Patient Education as Topic; D011203:Poverty / Q000523:psychology*; D011615:Psychotherapy, Group
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D017374:Paroxetine