[Correlation between amniotic fluid index (AFI) and glucose concentration in amniotic fluid, glycaemia, glycosylated haemoglobin concentration during normal pregnancy and pregnancy complicated by insulin-dependent diabetes mellitus].
BACKGROUND
In spite of confirming an association between type I diabetes of pregnancy with hydramnios, in the most recent studies there is still no clarity about which of the maternal or foetal metabolic parameters linked with amniotic fluid volume play the most important role.


OBJECTIVE
To determine which of the maternal or foetal metabolic parameters has the closest association with amniotic fluid volume.


METHODS
The research was performed in two groups: normal healthy pregnant women (n=43) and group of pregnant women with insulin-dependent diabetes mellitus (n=17) and their newborns. We measured: amniotic fluid index, glucose level in serum and in amniotic fluid, in newborn serum, HbA1c level in serum of women and newborns.


RESULTS
We found statistically significant higher values of amniotic fluid index 16.3 +/- 5.2 cm (p<0.01), glucose level in amniotic fluid 2.7 +/- 0.3 mmol/l (p<0.01), serum glucose level before delivery 8.4 +/- 1.6 mmol/l (p<0.001), glycosylated haemoglobin in serum levels 7.9 +/- 0.4% (p<0.05), levels of glucose and glycosylated haemoglobin in serum newborns 3.4 +/- 0.3 mmol/l (p<0.05), 7.7 +/- 0.4% (p<0.001) in patients with insulin-dependent diabetes mellitus as compared with these values in the group of healthy parturient women and their newborn infants. Performed correlation study shows statistical correlation between amniotic fluid index and glycosylated hemoglobin serum levels in the group of women with insulin-dependent diabetes mellitus (p<0.05), t=0.56.


CONCLUSIONS
We conclude that long hyperglycemia or increased HbA1c level have an important role in amniotic fluid index increase in patients with insulin-dependent diabetes mellitus.
Klinika i Oddział Kliniczny Połoznictwa i Ginekologii w Bytomiu, Slaska Akademia Medyczna w Katowicach, ul. Batorego 18, 41-902 Bytom, Poland. m16gm@tlen.pl
Jacek
J
Zamłyński
Piotr
P
Bodzek
Anita
A
Olejek
Grzegorz
G
Mańka
Krzysztof
K
Grettka
Barbara
B
Kobylec-Zamłyńska
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000032:analysis*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000378:metabolism*; D007231:Infant, Newborn / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000175:diagnosis / Q000378:metabolism*; D012016:Reference Values
D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin