Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression.
CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Ralpha expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.
Morrot
Alexandre
A
Department of Molecular Microbiology and Immunology, School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Cockburn
Ian A
IA
Overstreet
Michael
M
Rodríguez
Dolores
D
Zavala
Fidel
F
D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism* / Q000637:transplantation; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D007156:Immunologic Memory / Q000235:genetics; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000235:genetics; D018655:Lymphocyte Count; D008288:Malaria / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D017780:Malaria Vaccines / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D010967:Plasmodium yoelii / Q000254:growth & development / Q000276:immunology*; D011237:Predictive Value of Tests; D020395:Receptors, Interleukin-7 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
D017780:Malaria Vaccines; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain