Helicobacter pylori protein oxidation influences the colonization process.
Dsb proteins control the formation and rearrangement of disulfide bonds during the folding of membrane and exported proteins. Here we examined the role of DsbI protein in Helicobacter pylori pathogenesis and demonstrated that a dsbI mutant impaired in disulfide bond formation revealed a greatly reduced ability to colonize mice gastric mucosa.
Department of Bacterial Genetics, Institute of Microbiology, Warsaw University, Miecznikowa 1, PL-02-096 Warsaw, Poland.
Renata
R
Godlewska
Artur
A
Dzwonek
Michał
M
Mikuła
Jerzy
J
Ostrowski
Marcin
M
Pawłowski
Janusz M
JM
Bujnicki
Elzbieta K
EK
Jagusztyn-Krynicka
D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction; D019704:Protein Disulfide-Isomerases / Q000235:genetics / Q000378:metabolism*; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics*
D037521:Virulence Factors; D019704:Protein Disulfide-Isomerases