Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability.
The incorporation of butyl-methoxydibenzoylmethane (BMDBM), one of the most efficient and frequently used UV-A blockers, into lipospheres was examined in order to decrease the light-induced sunscreen degradation. Lipospheres, obtained by the melt technique and using tristearin as the lipid material and hydrogenated phosphatidylcholine as the emulsifier, showed proper features in terms of size (10-40 microm), BMDBM loading level (21.63% +/- 0.90%, w/w) and physical state. Photolysis studies, involving irradiation of lipospheres with simulated sunlight before and after their introduction in emulsion formulations, demonstrated a relevant enhancement of the encapsulated sunscreen photostability in comparison with unencapsulated BMDBM.
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Valentina
V
Iannuccelli
Nicoletta
N
Sala
Rosanna
R
Tursilli
Gilberto
G
Coppi
Santo
S
Scalia
D000473:Alkanes / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D047188:Chalcones / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010777:Photochemistry; D011427:Propiophenones
D000473:Alkanes; D047188:Chalcones; D008055:Lipids; D011427:Propiophenones; C049935:avobenzone