[Outline of HIV replication and its cellular factors: the track of an invader in the cell].
A number of novel findings with reference to HIV replication have been reported even though it passed more than 20 years after a first HIV isolation. Although many cellular factors are known to be involved in the HIV replication, recently investigators discovered novel HIV-suppressive cellular factors such as APOBEC or TRIM5 alpha. Here, I describe and discuss how HIV uses the cellular machinery for its replication.
Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Japan. ykoyanag@virus.kyoto-u.ac.jp
Yoshio
Y
Koyanagi
D000071480:APOBEC-3G Deaminase; D000818:Animals; D003564:Cytidine Deaminase; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral / Q000235:genetics; D006678:HIV / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D009700:Nucleoside Deaminases / Q000502:physiology; D014176:Protein Biosynthesis; D011506:Proteins / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics; D015728:Receptors, HIV / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D048348:Reverse Transcription; D044767:Ubiquitin-Protein Ligases; D014764:Viral Proteins / Q000235:genetics; D019065:Virus Assembly / Q000235:genetics; D016662:Virus Integration / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*
D004279:DNA, Viral; D011506:Proteins; D012367:RNA, Viral; D015728:Receptors, HIV; D012097:Repressor Proteins; D014764:Viral Proteins; C482587:TRIM5(alpha) protein, rhesus monkey; D044767:Ubiquitin-Protein Ligases; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase