A review of the clinical use of anti-inflammatory therapies for reperfusion injury in myocardial infarction and stroke: where do we go from here?
A number of prominent studies have been conducted using anti-inflammatory therapies to reduce reperfusion injury in myocardial infarction and stroke. Unfortunately, most strategies have failed. This review summarizes in detail the human studies of anti-inflammatory therapy that have been conducted to date. The potential reasons for treatment failure will be discussed from a non-clinical perspective, as will lessons learned from these studies that might guide the design of future clinical studies in this important area.
Kennedy
Thomas P
TP
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah Medical Center, Salt Lake City 84132, USA. Thomas.Kennedy@hsc.utah.edu
Vinten-Johansen
Jakob
J
D000241:Adenosine / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000628:therapy*; D020521:Stroke / Q000628:therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D014665:Vasodilator Agents; D000241:Adenosine