The role of the phospholipid sphingomyelin in heart disease.
Sphingomyelin (SM) is an integral component of mammalian cell membranes and nerves. However, the inability to catabolize SM may lead to its accumulation in various tissues and organs, resulting in pathological disorders such as Niemann Pick disease. Elevated levels of SM have also been identified as an independent risk factor for coronary heart disease. During the past two decades, data have emerged that support an important role for metabolites of SM, such as ceramide and sphingosine-1-phosphate, in the regulation of phenotypic changes such as cell proliferation, cell-cycle arrest, apoptosis and angiogenesis. Further studies of the molecular and pathobiological basis of these phospholipids may facilitate advances in the discovery of drugs with which to mitigate diseases that may result from an elevation in SM and its metabolites.
Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21205, USA. schatte2@jhmi.edu
Subroto
S
Chatterjee
Antonina
A
Kolmakova
Michael
M
Miller
D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D012307:Risk Factors; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013109:Sphingomyelins / Q000097:blood / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
D002518:Ceramides; D008246:Lysophospholipids; D013109:Sphingomyelins; C060506:sphingosine 1-phosphate; D013108:Sphingomyelin Phosphodiesterase; D013110:Sphingosine