Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: a single center experience in a cohort of 92 patients.
We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.
Department of Genetics, Biology and Biochemistry, University of Turin, Italy. fsizzano@molinette.piemonte.it
Federico
F
Sizzano
Paola
P
Magistroni
Franco
F
Locatelli
Alessandro
A
Busca
Michele
M
Falda
Paola
P
Affaticati
Gina
G
Mazzola
Anna Maria
AM
Dall'omo
Antonio
A
Amoroso
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000175:diagnosis*; D006680:HLA Antigens / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006650:Histocompatibility Testing; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D035781:Siblings; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000378:metabolism* / Q000637:transplantation; D014019:Tissue Donors
D006680:HLA Antigens