Folate supplementation and twinning in patients with sickle cell disease.
Patients with sickle cell disease routinely take folic acid daily as a supplement to maintain effective erythropoiesis. One of the controversial effects of folic acid is its effect on twin gestation rates. In this report, we present our experience in patients with sickle cell disease and twin pregnancy. Our data show that twin pregnancies seem to be associated with folate supplementation.
Ballas
Samir K
SK
Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. samir.ballas@jefferson.edu
Baxter
Jason K
JK
Riddick
Gaye
G
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000178:diet therapy; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005492:Folic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D006397:Hematinics / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D010298:Parity / Q000187:drug effects; D011247:Pregnancy; D038522:Twinning, Monozygotic / Q000187:drug effects; D014806:Vitamin B 12 Deficiency / Q000209:etiology
D006397:Hematinics; D005492:Folic Acid