Absolute counting of 188Re radiopharmaceuticals.
The Institute of Nuclear Energy Research (INER) has provided 188Re radiopharmaceuticals for hospitals in Taiwan. To enhance the accuracy of commercial radionuclide calibrators used by radiopharmacies and hospitals, and to ensure that patients receive proper doses of these radiopharmaceuticals, it is very important to standardize this nuclide. The 4pibeta-gamma coincidence counting method was used to standardize the mass activities of 188Re in this study. At the same time, three well type ionization chambers, Centronic IG11-N20, Centronic IG11-A20, and ISOCAL-IV, were calibrated by the standardized solutions of the nuclide. In this research, the calibration figures of ISOCAL-IV for the nuclide were consistent with the results of National Physical Laboratory (NPL, UK). The outcome implied that the results of coincidence counting did mutually agree. On the other hand, the radionuclide calibrator in the radiopharmacy was producing measurement errors of about 20% when using the manufacturers recommended calibration setting: an accurate correction factor has now been determined in this study.
Yuan
Ming-Chen
MC
National Radiation Standard Laboratory, Institute of Nuclear Energy Research, No. 1000, Wunhua Rd., Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan, ROC. mcyuan@iner.gov.tw
Pang
Hsiao-Fang
HF
Wang
Chu-Fang
CF
D011829:Radiation Dosage; D011868:Radioisotopes / Q000032:analysis* / Q000592:standards*; D011874:Radiometry / Q000379:methods* / Q000592:standards; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000592:standards*; D012015:Reference Standards; D012016:Reference Values; D015203:Reproducibility of Results; D012211:Rhenium / Q000032:analysis* / Q000592:standards*; D012680:Sensitivity and Specificity; D013051:Spectrometry, Gamma / Q000379:methods / Q000592:standards; D013624:Taiwan
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium