Lipid lowering activity of hydrosoluble chitosan and association with Aloe vera L. and Brassica olearaceae L.
The lipid lowering activity of chitosan associated with Aloe vera L. or hydrosoluble chitosan with Brassica olearaceae L. has been studied in rats. In this study, rats were submitted to different treatments with hydrosoluble chitosan alone (4% diet), hydrosoluble chitosan associated with Aloe vera L. or hydrosoluble chitosan with Brassica olearaceae L. (1:4, 4% diet) for 35 days, to identify the formula with the highest hypolipaemic potential. The results showed that all treatments reduced blood lipid levels but that hydrosoluble chitosan associated with Brassica olearaceae L. proved most efficient, because it decreased the levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides in blood serum. The overall results suggest that the hydrosoluble chitosan/Brassica olearaceae L. association is a therapeutic alternative for hyperlipidaemia, and in this way may contribute to the prevention of atherogenic processes.
Pharmacy Department, Extremo Sul Catarinense University, Criciúma, Santa Catarina, Brazil.
R
R
Geremias
R C
RC
Pedrosa
C
C
Locatelli
V T
VT
de Fávere
R
R
Coury-Pedrosa
M C M
MC
Laranjeira
D000504:Aloe; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001937:Brassica; D048271:Chitosan / Q000008:administration & dosage* / Q000009:adverse effects; D002784:Cholesterol / Q000097:blood; D004338:Drug Combinations; D004357:Drug Synergism; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004338:Drug Combinations; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D048271:Chitosan; D002784:Cholesterol