Disposition of arsenobetaine in two marine fish species following administration of a single oral dose of [14C]arsenobetaine.
The distribution and excretion of arsenobetaine in fish were investigated using whole body autoradiography and liquid scintillation counting. A single dose of synthesised [(14)C]arsenobetaine was orally administered to Atlantic salmon, Salmo salar L., and Atlantic cod, Gadus morhua L. Arsenobetaine was distributed to most organs within both species. Nevertheless, there were species differences in tissue distribution and excretory pattern. The highest level of arsenobetaine in Atlantic salmon was present in muscle tissue, while high levels of arsenobetaine were found in both muscle and liver (including gall bladder) from Atlantic cod. The results suggest that the major route of excretion was via urine, which seemed to be more important in Atlantic cod than in Atlantic salmon. Elimination of arsenobetaine via bile appeared to be negligible in both species.
National Institute of Nutrition and Seafood Research, Bergen, Norway. heidi.amlund@nifes.no
Heidi
H
Amlund
Kristian
K
Ingebrigtsen
Ketil
K
Hylland
Anders
A
Ruus
Dag Øistein
DØ
Eriksen
Marc H G
MH
Berntssen
D000284:Administration, Oral; D000818:Animals; D001152:Arsenicals / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D001345:Autoradiography; D002250:Carbon Radioisotopes; D048389:Gadus morhua / Q000378:metabolism* / Q000652:urine; D020317:Salmo salar / Q000378:metabolism* / Q000652:urine; D012588:Scintillation Counting; D013045:Species Specificity; D014018:Tissue Distribution
D001152:Arsenicals; D002250:Carbon Radioisotopes; C038992:arsenobetaine