One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
Ilyn
Alexey P
AP
Department of Organic Chemistry, Chemical Diversity Research Institute, 114401 Khimki, Moscow Reg., Russia.
Loseva
Marina V
MV
Vvedensky
Vladimir Y
VY
Putsykina
Elena B
EB
Tkachenko
Sergey E
SE
Kravchenko
Dmitri V
DV
Khvat
Alexandr V
AV
Krasavin
Mikhail Y
MY
Ivachtchenko
Alexandre V
AV
D002219:Carbamates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry
D002219:Carbamates; D013841:Thiazepines; C070766:carbamic acid