Akt1 in endothelial cell and angiogenesis.
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Payaningal R
PR
Somanath
Olga V
OV
Razorenova
Juhua
J
Chen
Tatiana V
TV
Byzova
D000818:Animals; D042783:Endothelial Cells / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D010766:Phosphorylation; D020033:Protein Isoforms; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction
D020033:Protein Isoforms; D051057:Proto-Oncogene Proteins c-akt