Role of resistin in inflammation and inflammation-related diseases.
Resistin is a newly identified adipocyte secreted hormone belonging to a cysteine-rich protein family. It is expressed in white adipose tissues in rodents and has also been found in several other tissues in human. Insulin, glucose, many cytokines and anti-diabetic thiazolidinediones are regulators of resistin gene expression. Resistin was firstly proposed to be involved in insulin resistance and type 2 diabetes. Recently, it was found to be relevant to inflammation and inflammation-related diseases like atherosclerosis and arthritis.
Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, China.
Shan Shan
SS
Pang
Ying Ying
YY
Le
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001168:Arthritis / Q000188:drug therapy / Q000378:metabolism*; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D007333:Insulin Resistance; D051379:Mice; D051381:Rats; D052243:Resistin / Q000378:metabolism*; D045162:Thiazolidinediones / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D052243:Resistin; D045162:Thiazolidinediones