Neurological diseases that cause detrusor hyperactivity with impaired contractile function.
OBJECTIVE
Detrusor hyperactivity with impaired contractile function (DHIC) was originally described in elderly women. It has not previously been well known whether neurological diseases cause DHIC. We investigated which neurological diseases commonly cause DHIC in our laboratory.


METHODS
We searched for DHIC in our laboratory's computerized database of 1,514 case records, which included a lower urinary tract (LUT) symptom questionnaire and urodynamic study results. DHIC was defined as the presence of both (1) detrusor overactivity during the storage phase, and (2) underactive detrusor contraction during the evacuation phase.


RESULTS
Two hundred and seventeen patients met the criteria for DHIC: 122 men and 95 women; mean age, 63 years. The neurological diseases that caused DHIC included Parkinsonian syndrome (18%), multiple system atrophy (18%), progressive supranuclear palsy/corticobasal degeneration (14%), multiple cerebral infarction (MCI) (12%), multiple sclerosis/acute disseminated encephalomyelitis (18%), spinal cord lesions (15%), and cervical spondylotic myelopathy (CS) (10%).


CONCLUSIONS
The present study revealed that a wide spectrum of neurological disorders could cause DHIC.
Yamamoto
Tatsuya
T
Department of Neurology, Chiba University, Chiba, Japan. tatsuya-yamamoto@mbc.nifty.com
Sakakibara
Ryuji
R
Uchiyama
Tomoyuki
T
Liu
Zhi
Z
Ito
Takashi
T
Awa
Yusuke
Y
Yamanishi
Tomonori
T
Hattori
Takamichi
T
D000328:Adult; D000368:Aged; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009122:Muscle Hypertonia / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D009422:Nervous System Diseases / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D011795:Surveys and Questionnaires; D014563:Urodynamics