Antibacterial evaluation of 1,4-benzoquinone derivatives.
We investigated the antibacterial activity of some new 2-aryl-3,5-dimethoxy-1,4-benzoquinone derivatives, previously prepared from 2,6-dimethoxy-1,4-benzoquinone by Suzuki cross-coupling reactions, to find effective antibacterial agents. The antibacterial activity was first tested in vitro by the disk diffusion assay against two gram-positive and two gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of active compounds was determined. The results showed that some 2-aryl-3,5-dimethoxy-1,4-benzoquinone derivatives inhibit growth of both gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), microorganisms that cause food poisoning and rheumatic fever. This study points out the antibacterial activity of some 2-aryl-3,5-dimethoxy-1,4-benzoquinone derivatives.
Lana
Enio J L
EJ
Department of Chemistry, ICEx, University Federal of Minas Gerais, Av. Antônio Carlos 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Carazza
Fernando
F
Takahashi
Jacqueline A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D016227:Benzoquinones