Cobalt(II) chloride catalyzed one-pot synthesis of alpha-aminonitriles.
A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-pot three- component condensation of aldehydes, amines, and potassium cyanide in acetonitrile in the presence of a catalytic amount of CoCl2 at room temperature.
De
Surya K
SK
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA. skd125@pharmacy.purdue.edu