PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803.
Cyanophycin (multi-L-arginyl-poly-L-aspartic acid) is a nitrogen storage polymer found in most cyanobacteria and some heterotrophic bacteria. The cyanobacterium Synechocystis sp. strain PCC 6803 accumulates cyanophycin following a transition from nitrogen-limited to nitrogen-excess conditions. Here we show that the accumulation of cyanophycin depends on the activation of the key enzyme of arginine biosynthesis, N-acetyl-L-glutamate kinase, by signal transduction protein PII.
Maheswaran
Mani
M
Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig Universität Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany.
Ziegler
Karl
K
Lockau
Wolfgang
W
Hagemann
Martin
M
Forchhammer
Karl
K
D001120:Arginine / Q000096:biosynthesis*; D001426:Bacterial Proteins; D051922:PII Nitrogen Regulatory Proteins / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism*; D046939:Synechocystis / Q000145:classification* / Q000378:metabolism*; D013997:Time Factors
D001426:Bacterial Proteins; D051922:PII Nitrogen Regulatory Proteins; D010940:Plant Proteins; C024250:cyanophycin; D001120:Arginine