Biological activities of some natural compounds from Sideritis sipylea Boiss.
In this work, several diterpenes including siderol, linearol and epicandicandiol were isolated from Sideritis sipylea Boiss collected from Izmir-Karaburun-Akdag, Turkey. In addition, diacetate derivatives of linearol and epicandicandiol were obtained. The antimicrobial activites of all these compounds against the bacteria Staphylococcus aureus (ATTC 25923), Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC 11230), Pseudomonas aeruginosa (ATCC 27853) and the fungus Candida albicans (ATCC 90028) were studied. Antimicrobal activity was measured by the well-diffusion method. Except for C. albicans all microorganisms were tested against antibiotic discs in comparison with the studied compounds.
Ankara University, Science Faculty Department of Chemistry, 06100 Tandogan, Ankara, Turkey. logoglu@science.ankara.edu.tr
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Loğoğlu
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Arslan
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Oktemer
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Sakõyan
D001412:Bacillus subtilis; D002176:Candida albicans; D004224:Diterpenes / Q000032:analysis* / Q000494:pharmacology*; D004926:Escherichia coli; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa; D031365:Sideritis / Q000737:chemistry*; D013211:Staphylococcus aureus
D004224:Diterpenes; C476658:epicandicandiol; C471495:linearol