The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer.
It has previously been reported that intratumoral microvessel density (IMD), and the expression of bFGF and nm23-H1 are useful prognostic markers in colorectal cancer (CRC). In this study, a total of 100 CRCs were evaluated histopathologically, and IMD, bFGF and nm23-H1 expression were assessed by immunohistochemistry. IMD of patients increased with grade and stage, and this increase was statistically significant (p<0.05). A significantly higher incidence of high bFGF expression scores was also associated with increasing grade and stage (p<0.05). However, there was no significant difference between the grades in nm23-H1 expression (p=0.234). nm23-H1 expression occurred with lower incidence in stages C1, C2 and D than in stages B1 and B2 (p<0.05). Thus, a negative correlation was found between nm23-H1 expression and stage or lymph node metastasis (LNM) (p<0.05). IMD and bFGF expression were positively correlated with grade, stage, LNM, and lymphovascular invasion. Although positive correlation was found between IMD and bFGF, nm23-H1 expression negatively correlated with both of them. As a result, in clinical practice, increased IMD and bFGF expression and decreased nm23-H1 expression may provide valuable information in characterizing the malignant phenotype.
Department of Pathology, Cumhuriyet University School of Medicine, Sivas, 58140, Turkey. selagoz@cumhuriyet.edu.tr
Sahande
S
Elagoz
Reyhan
R
Egilmez
Ayhan
A
Koyuncu
Ahmet
A
Muslehiddinoglu
Sema
S
Arici
D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D011379:Prognosis
D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D005346:Fibroblast Growth Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase