[Successful treatment of acquired haemophila associated with psoriasis--case report].
Acquired factor VIII (FVIII) inhibitor causes a rare but life-threatening form of bleeding disorder, owing to the formation of autoantibodies against FVIII. Treatment modalities include the use of immunosuppressive drugs, such as cyclophosphamide and corticosteroids, plasmapheresis, and i.v. immunoglobulin. The case of a 67-year-old patient with acquired FVIII inhibitor and psoriasis presented us with a serious bleeding complication. Bleeding reacted poorly to therapy with corticosteroids and cyclophosphamide. Treatment with cyclosporin, however, resulted in a prompt and complete response. The lack of side effects and the relatively quick response suggest that cyclosporin A should be tried as a frontline treatment for patients with acquired FVIII inhibitor.
Goran
G
Marjanović
Vesna
V
Marjanović
Ljubinka
L
Velicković
Mladen
M
Milenović
Lana
L
Macukanović-Golubović
Irena
I
Cojbasić
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000150:complications*
D001323:Autoantibodies; D005169:Factor VIII