[Structure and biologic function of IFNgamma].
IFNgamma is a pro-inflammatory, pleiotropic cytokine mainly produced by the CD4+, CD8+ lymphocytes and NK cells, that play an important role in macrophage activation, antigen presentation enhance and induce innate, and acquired immune responses. IFNgamma by interaction with they cell-surface receptors (IFNgammaR) activates cellular effects including stimulation of antiviral and antimicrobial mechanisms, inhibition of cellular proliferation, regulates cells apoptosis and leukocyte trafficing to sites of inflammation. The purpose of this article is to present the current understending of structure and biological function of IFNgamma in the light of current opinions regarding this matter.
SP ZOZ WSPR w Białymstoku. namdalia2@wp.pl
Abdul Halim
AH
Nammous
Małgorzata
M
Pietruczuk
Dymitr
D
Zubacki
Ignacy
I
Dobrzycki
D015704:CD4 Antigens / Q000502:physiology; D016827:CD8 Antigens / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D007371:Interferon-gamma / Q000737:chemistry* / Q000502:physiology*; D008214:Lymphocytes / Q000166:cytology; D019001:Nitric Oxide Synthase / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015704:CD4 Antigens; D016827:CD8 Antigens; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D019001:Nitric Oxide Synthase