Acute portal and mesenteric thrombosis: unusual presentation of cytomegalovirus infection.
Cytomegalovirus infection is a benign disease in immunocompetent patients. In-vitro and in-vivo studies show that cytomegalovirus may cause arterial and venous thrombosis through different mechanisms. We describe two cases of acute cytomegalovirus infection complicated by portal and mesenteric vein thrombosis leading to intestinal ischemia. Both patients carried the heterozygous prothrombin G20210A mutation. The presence of this unusual complication should be searched for in patients with acute cytomegalovirus infection and abdominal symptoms in order to start early anticoagulation. The necessity for full thrombophilic screening is also pointed out.
Amitrano
Lucio
L
Gastroenterology Unit, A. Cardarelli Hospital, Naples, Italy. luamitra@tin.it
Guardascione
Maria Anna
MA
Scaglione
Mariano
M
Menchise
Antonella
A
Romano
Luigia
L
Balzano
Antonio
A
D000208:Acute Disease; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications*; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology*; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000150:complications*; D008642:Mesenteric Veins; D011169:Portal Vein; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging