Diagnosing glaucoma progression: current practice and promising technologies.
OBJECTIVE
An update on recent work is provided that has broadened our understanding of the evaluation of visual function and structure, and their use in evaluating glaucoma progression.


RESULTS
The challenge of determining visual-field progression and the implications of long-term fluctuation are reviewed and data to support the magnitude of the fluctuation are cited. The use of confirmatory testing can limit the over diagnosis of glaucoma progression. Focusing visual-field testing on the locations of present scotomas or using frequency doubling technology may provide new approaches to assessing visual function. New standardized techniques to interpret visual fields, including neural networks, unsupervised machine learning and pointwise linear regression, may provide more quantitative means for visual-field interpretation. These techniques, along with structural evaluation of the optic nerve and nerve fiber layer, are essential in glaucoma management. Optic-nerve-head photography is still a mainstay in evaluating glaucoma progression, although many technologies including scanning laser tomography, scanning laser polarimetry and optical coherence tomography offer more quantitative means to follow structural change. These modalities, in different ways, show promise in providing additional information regarding the stability of glaucoma.


CONCLUSIONS
Identifying the functional visual component as well as structural changes is essential in evaluating glaucoma progression. New techniques of testing and evaluating visual fields, the optic-nerve head, and the retinal nerve fiber layer offer exciting opportunities to more accurately identify glaucoma progression, and are likely to become more central as imaging devices and software support develop further.
Giangiacomo
Annette
A
David Geffen School of Medicine at UCLA, Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, California 90095, USA.
Garway-Heath
David
D
Caprioli
Joseph
J
D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D013673:Technology Assessment, Biomedical; D014786:Vision Disorders / Q000175:diagnosis*; D014794:Visual Fields