A very simple, highly stereoselective and modular synthesis of ferrocene-based P-chiral phosphine ligands.
A very simple, highly stereoselective and modular synthesis of ferrocene-based P-chiral phosphine ligands has been developed. On the basis of this new methodology, several new families of ferrocene-based phosphine ligands have been prepared coupling chirality at phosphorus with other, more standard stereogenic features. The introduction of P-chirality into ferrocene-based phosphine ligands enhances the enantioselective discrimination produced by the corresponding Rh catalyst when a matching among the planar chirality, carbon chirality, and the chirality of phosphorus is achieved.
Chen
Weiping
W
StylaCats Ltd., Chemistry Department, University of Liverpool, Liverpool L69 7ZD, United Kingdom. weiping.chen@solvias.com
Mbafor
William
W
Roberts
Stanley M
SM
Whittall
John
J