Synthesis of aminoacyl thiaolidones as potential antitumour agents.
In the scope of a research program aiming to perform the synthesis and pharmacological evaluation of novel possible antitumour prototype compounds, we report in this paper the synthesis of new peptidyl derivatives from 4-thiazolidone nucleus. The synthesis reactions have been performed based in peptide synthesis as strategies. The characterisation of this new class of compounds was performed with IR and (1)H-NMR spectroscopy. In vivo, antitumour activity tests showed that some of these compounds were able to inhibit significantly sarcoma S-180 tumour growth in mice, revealing itself as a new potential class of drugs in cancer chemotherapy.
Laboratório de Planejamento, Avaliação e Síntese de Fármacos, LABSINFA, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Rua Prof. Artur Sa, S/N, CDU, Recife, Pernambuco, Brazil. acllb@yahoo.com.br
Ana Cristina
AC
Lima Leite
Luciene Maria F
LM
Santos
Fábio Fernandes
FF
Barbosa
Marcos V
MV
de Oliveira Cardoso
Diogo Rodrigo M
DR
Moreira
Ivone Antonia
IA
de Souza
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D045744:Cell Line, Tumor; D005260:Female; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D013844:Thiazoles