Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis.
We have shown that splenic lymphocytes from mice immunized with viable attenuated mycobacterial cells (H37Ra) or ribonucleic acid prepared from these cells will bring about inhibition of multiplication of virulent tubercle bacilli (H37Rv) within normal mouse peritoneal macrophages in tissue culture. Apparently these lymphocytes, when stimulated with viable virulent tubercle bacilli, elaborate a filterable substance(s) which is responsible for this intracellular growth inhibitory effect.
Patterson
R J
RJ
Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611.
Youmans
G P
GP