Projections from auditory cortex to cochlear nucleus: A comparative analysis of rat and mouse.
Mammalian hearing is a complex special sense that involves detection, localization, and identification of the auditory stimulus. The cerebral cortex may subserve higher auditory processes by providing direct modulatory cortical projections to the auditory brainstem. To support the hypothesis that corticofugal projections are a conserved feature in the mammalian brain, this article reviews features of the rat corticofugal pathway and presents new data supporting the presence of similar projections in the mouse. The mouse auditory cortex was localized with electrophysiological recording and neuronal tracers were injected into AI. The cochlear nucleus was dissected and examined for terminal fibers by light and electron microscopy. Bouton endings were found bilaterally forming synapses with dendrites of granule cells of the cochlear nucleus. This report provides evidence for direct auditory cortex projections to the cochlear nucleus in the mouse. The distribution of projections to the granule cell domain and the synapses onto granule cell dendrites are consistent with what has been reported for rats and guinea pigs. These findings suggest a general plan for corticofugal modulation of ascending auditory information in mammals. Corticobulbar inputs to the auditory brainstem likely provided a survival advantage by improving sound detection and identification, thus allowing the development of complex social behaviors and the navigation of varied environments.
Department of Otolaryngology-Head and Neck Surgery (HNS), Center for Hearing and Balance, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Noah E
NE
Meltzer
David K
DK
Ryugo
D000818:Animals; D001303:Auditory Cortex / Q000033:anatomy & histology*; D017626:Cochlear Nucleus / Q000033:anatomy & histology* / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D017729:Presynaptic Terminals / Q000648:ultrastructure; D011712:Pyramidal Tracts / Q000033:anatomy & histology; D051381:Rats