Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation.
Hemoglobin-Vesicles (HbV; diameter, 250 nm) are artificial O2 carriers encapsulating purified and concentrated human Hb solution in phospholipid vesicles (liposomes), and their safety and efficacy, as a transfusion alternative, have been studied. In this paper, we summarized the characteristics of HbV that have been clarified by the microcirculatory observations.
Sakai
Hiromi
H
Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. hiromi@waseda.jp
Tsuchida
Eishun
E
D001802:Blood Substitutes / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D006454:Hemoglobins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008081:Liposomes; D008833:Microcirculation / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*
D001802:Blood Substitutes; D004337:Drug Carriers; D006454:Hemoglobins; D008081:Liposomes; C109960:PEG-hemoglobin; D011092:Polyethylene Glycols; D010100:Oxygen