Lack of association of type 1 diabetes with the IL4R gene.
OBJECTIVE
The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background.


METHODS
We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset.


RESULTS
No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test.


CONCLUSIONS
Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.
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Endocrine Genetics Laboratory, The McGill University Health Center, (Montreal Children's Hospital), Montréal, QC, Canada.
Tessier
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MC
Fréchette
R
R
Bacot
F
F
Polychronakos
C
C
D002170:Canada; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005602:France / Q000208:ethnology; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D044465:White People
D019948:Receptors, Interleukin-4