Microarray analysis of the osmotic stress response in Pseudomonas aeruginosa.
Transcriptional profiling of Pseudomonas aeruginosa grown under steady-state hyperosmotic stress conditions showed an up-regulation of genes associated with osmoprotectant synthesis, putative hydrophilins, and the type III secretion system with associated cytotoxins. A large number of regulatory genes, including several two-component systems not previously known to be influenced by osmolarity, were differentially expressed by P. aeruginosa in immediate response to hyperosmotic shock.
Aspedon
Arden
A
School of Allied Health Sciences, Southwestern Oklahoma State University, Weatherford, OK 73096, USA. arden.aspedon@swosu.edu
Palmer
Kelli
K
Whiteley
Marvin
M
D001426:Bacterial Proteins / Q000235:genetics*; D001622:Betaine; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D009994:Osmolar Concentration; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors
D001426:Bacterial Proteins; D001622:Betaine