A practical one-pot synthesis of enantiopure unsymmetrical salen ligands.
A practical, one-pot synthesis of enantiopure unsymmetrical salen ligands is described, using a 1:1:1 molar ratio of a chiral diamine and two different salicylaldehydes. The new synthetic protocol can be readily performed in good yields (60-85%) on a multigram scale with good tolerance toward various functional groups.
Holbach
Michael
M
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.
Zheng
Xiaolai
X
Burd
Caroline
C
Jones
Christopher W
CW
Weck
Marcus
M