Amelioration of anemia after kidney transplantation in severe secondary oxalosis.
BACKGROUND
In small bowel disease such as M. Crohn, the intestinal absorption of oxalate is increased. Severe calcium oxalate deposition in multiple organs as consequence of enteric hyperoxaluria may lead to severe organ dysfunction and chronic renal failure. The management of hemodialyzed patients with short bowel syndrome may be associated with vascular access problems and oxalate infiltration of the bone marrow leading to pancytopenia. Although the risk of recurrence of the disease is very high after renal transplantation, it may be the ultimate therapeutic alternative in secondary hyperoxaluria.


METHODS
Here, we report a patient with enteric oxalosis due to Crohn's disease. He developed end-stage renal disease, erythropoietin-resistant anemia, oxalate infiltration of the bone marrow and severe vascular access problems. Following high-urgency kidney transplantation, daily hemodiafiltration of 3 hours was performed for 2 weeks to increase oxalate clearance. Despite tubular and interstitial deposition of oxalate in the renal transplant, the patient did not require further hemodialysis and the hematocrit levels normalized.


CONCLUSIONS
Early treatment of hyperoxaluria due to short bowel syndrome is essential to prevent renal impairment. Declining renal function leads to a further increase in oxalate accumulation and consecutive oxalate deposition in the bone marrow or in the vascular wall. If alternative treatments such as special diet or daily hemodialysis are insufficient, kidney transplantation may be a therapeutic alternative in severe cases of enteric oxalosis despite a possible recurrence of the disease.
Division of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany. wanja.bernhardt@med4.uni-erlangen.de
W M
WM
Bernhardt
J C
JC
Schefold
W
W
Weichert
B
B
Rudolph
U
U
Frei
D A
DA
Groneberg
R
R
Schindler
D000328:Adult; D000740:Anemia / Q000209:etiology*; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003424:Crohn Disease / Q000150:complications; D005500:Follow-Up Studies; D006801:Humans; D006959:Hyperoxaluria / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D012075:Remission, Spontaneous; D012720:Severity of Illness Index