T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha.
Experimental T cell-mediated hepatitis induced by concanavalin A (ConA) results in the initiation of an inflammatory response and the production of cytokines. Adiponectin is an adipocytokine produced by adipose tissue that is involved in the reciprocal regulation of other cytokines, including tumor necrosis factor alpha (TNF-alpha). Concanavalin A administration to C57BL/6J mice reduced circulating levels of adiponectin, whereas leptin was markedly increased. Adiponectin messenger RNA expression in adipose tissue was also decreased; however, the expression of both the adiponectin receptors remained unchanged. Neutralization of TNF-alpha reduced ConA-induced liver damage, and this was associated with restored circulating levels of adiponectin. These findings indicate that inflammation-induced TNF-alpha is a critical mediator of adipose-tissue-derived adiponectin in vivo.
Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Alison M
AM
Morris
Joseph A
JA
Sennello
Raja A
RA
Fayad
Robert H
RH
Eckel
Charles A
CA
Dinarello
Giamila
G
Fantuzzi
D052242:Adiponectin / Q000097:blood* / Q000235:genetics; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003208:Concanavalin A; D006505:Hepatitis / Q000097:blood / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D020738:Leptin / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens; D012333:RNA, Messenger / Q000378:metabolism; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface / Q000378:metabolism; D013601:T-Lymphocytes; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
D052242:Adiponectin; D020738:Leptin; D008934:Mitogens; D012333:RNA, Messenger; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; C475419:adiponectin receptor 1, mouse; C475421:adiponectin receptor 2, mouse; D003208:Concanavalin A