Preparation and characterization of lyophilized liposomes with incorporated quercetin.
Liposomes composed of egg-phosphatidylcholine (EPC) incorporating quercetin (QR) were prepared by the thin-film hydration method (TFHM) and the monophase solution method (MSM). A rapid and slow freeze-drying process was applied for both laboratory and industrial scales. The purpose of this study was to compare the two methods of liposome preparation, and further determine whether the lyophilization process affects the liposome physicochemical characteristics (size, polydispersity index, and ?-potential) and incorporation of quercetin.
Department of Pharmaceutical Technology, School of Pharmacy, Panepistimiopolis Zografou, 15771 Athens, Greece.
Elena
E
Alexopoulou
Aristidis
A
Georgopoulos
Konstantinos A
KA
Kagkadis
Costas
C
Demetzos
D002855:Chromatography, Thin Layer; D005612:Freeze Drying; D008081:Liposomes; D011794:Quercetin / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D008081:Liposomes; D011794:Quercetin