[The protective activity of a new variant of the probiotic Acilact in exposure to ionizing radiation and anticancer chemotherapy under experimental conditions].
The aim of the study was to investigate the protective activity of a new variant of the probiotic Acilact in exposure to ionizing radiation and anticancer chemotherapy under experimental conditions. The study revealed protective effects of the preparation after combined exposure of mice to radiation and temperature. The preparation increased 30-day survival of the mice, inhibited intestinal colonization with gram-negative microorganisms, and increased resistance to LPS. A multidirectional protective effect of the probiotic was observed after the use of sublethal doses of radiation; this effect was manifested by quicker normalization of hematological parameters and bone marrow cellularity, as well as elevation of blood concentration of the hemoragulatory cytokines IL-3 and IL-6.
Budagov
R S
RS
Ul'ianova
L P
LP
Pospelova
V V
VV
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005500:Follow-Up Studies; D007779:Lactobacillus acidophilus; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000532:radiotherapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D019936:Probiotics / Q000627:therapeutic use*; D011832:Radiation Injuries; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001688:Biological Products; C084209:acilact