Vanadyl sulfate administration protects the streptozotocin-induced oxidative damage to brain tissue in rats.
Diabetes mellitus manifests itself in a wide variety of complications and the symptoms of the disease are multifactorial. The present study was carried out to investigate the effects of vanadyl sulfate on biochemical parameters, enzyme activities and brain lipid peroxidation, glutathione and nonenzymatic glycosylation of normal- and streptozotocin-diabetic rats. Streptozotocin (STZ) was administered as a single dose (65 mg/kg) to induce diabetes. A dose of 100 mg/kg vanadyl sulfate was orally administered daily to STZ-diabetic and normal rats, separately until the end of the experiment, at day 60. In STZ-diabetic group, blood glucose, serum sialic and uric acid levels, serum catalase (CAT) and lactate dehydrogenase (LDH) activities, brain lipid peroxidation (LPO) and nonenzymatic glycosylation (NEG) increased, while brain glutathione (GSH) level and body weight decreased. In the diabetic group given vanadyl sulfate, blood glucose, serum sialic and uric acid levels, serum CAT and LDH activities and brain LPO and NEG levels decreased, but brain GSH and body weight increased. The present study showed that vanadyl sulfate exerted antioxidant effects and consequently may prevent brain damage caused by streptozotocin-induced diabetes.
Faculty of Engineering, Department of Chemistry, Istanbul University, 34320 Avcilar, Istanbul, Turkey. yanardag@istanbul.edu.tr
Refiye
R
Yanardag
Sevim
S
Tunali
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002374:Catalase / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D005978:Glutathione / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity; D014527:Uric Acid / Q000097:blood; D017968:Vanadium Compounds / Q000008:administration & dosage / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; D014527:Uric Acid; D013311:Streptozocin; C034028:vanadyl sulfate; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D005978:Glutathione; D019158:N-Acetylneuraminic Acid