Important parameters for the manufacture of slow-release matrix pellets with an aqueous dispersion of quaternary poly(meth)acrylates in the rotary fluidized bed.
The manufacture of slow-release matrix pellets with an aqueous dispersion of quaternary poly(meth)acrylates was investigated in the rotary fluidized bed. By considering the moisture content of the fluidized bed to be the key process parameter, it was measured on-line throughout the whole manufacturing process. A specially designed sampling device opened new ways to apply NIR spectrometry in laboratory scale processes. It was shown that reproducibly improved pellet properties can be achieved by reproducing the moisture content of the (rotary) fluidized bed. Moisture plateaus proved to be a suitable way to optimize the sphericity of the pellets. Premoisturizing was found to be a very effective tool to achieve slow-release dissolution of the model drug theophylline.
Department of Launch Production, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany. guido.radtke@t-online.de
Guido
G
Radtke
Klaus
K
Knop
Bernhard C
BC
Lippold
D000180:Acrylic Resins / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D010316:Particle Size; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D013806:Theophylline / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D014867:Water; C050528:Eudragit RS; D013806:Theophylline