Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women.
OBJECTIVE
Animal research suggests that oxytocin (OT) plays a role in stress responses and that in females, this role is modulated by estrogen. Yet little is known about the relation of OT to human stress responses. This study was conducted to examine the relations between estrogen activity and OT, identify stressors distinctively associated with elevations in OT, and investigate whether OT is related to cardiovascular and hypothalamic-pituitary-adrenocortical (HPA) activity in a laboratory challenge paradigm.


METHODS
Seventy-three postmenopausal women who were on hormone therapy (HT) or not completed questionnaires assessing psychological distress and social relationships and then participated in a laboratory stress challenge (Trier Social Stress Task), during which OT, cortisol, and blood pressure were assessed.


RESULTS
HT was significantly associated with higher plasma OT. Controlling for HT, elevated plasma OT was significantly associated with gaps in social relationships, with less positive relationships with a primary partner, and with elevated cortisol levels. OT was not associated with stress reactivity or recovery.


CONCLUSIONS
In women, plasma OT signals relationship stress and is associated with elevated cortisol; it does not appear to significantly affect cortisol or blood pressure responses to acute stress.
Taylor
Shelley E
SE
Department of Psychology, University of California, Los Angeles, CA 90095, USA. taylors@psych.ucla.edu
Gonzaga
Gian C
GC
Klein
Laura Cousino
LC
Hu
Peifeng
P
Greendale
Gail A
GA
Seeman
Teresa E
TE
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D004967:Estrogens / Q000097:blood; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D007398:Interpersonal Relations; D008875:Middle Aged; D010121:Oxytocin / Q000096:biosynthesis* / Q000097:blood; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D017698:Postmenopause; D012934:Social Isolation / Q000523:psychology; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology* / Q000523:psychology
D004967:Estrogens; D010121:Oxytocin; D006854:Hydrocortisone