Airway remodeling from bench to bedside: current perspectives.
Bronchospasm and airway inflammation can lead to a constellation of irreversible changes in airway structure termed remodeling. Remodeling theory offers insight into the permanent biomechanical and pathologic alterations of asthmatic airways. Structural changes seen in asthmatic patients can include thickening of the airway wall reticular basement membrane (RBM), the presence of an abnormal elastic fiber network, and alterations in airway cartilage structure. Although steroid therapy is helpful in symptomatic control, it does not remedy structural alterations or many aspects of the inflammatory milieu. This article discusses several studies and supports the need for further investigation.
Slade
David J
DJ
Department of Pediatrics, Division of Pulmonology, Duke University Medical Center, Durham, NC 27710, USA. slade012@mc.duke.edu
Kraft
Monica
M
D001249:Asthma / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D001986:Bronchial Spasm / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D020545:Respiratory Mucosa / Q000473:pathology / Q000503:physiopathology