Myelodysplasia with isolated trisomy 15: a 15-year follow-up without specific therapy.
A 41-year-old patient manifested pancytopenia with macrocytosis following pesticide exposure. She was later found to have myelodysplasia with trisomy 15. Over a 15-year period of observation, and with no specific therapy, her hematological disorder remains stable, despite persistence of the chromosomal aberration. This and similar reported observations suggest that the course of this uncommon form of myelodysplasia is often indolent and not accurately predicted by application of the widely used International Prognostic Scoring System for the myelodysplastic syndromes.
Natelson
Ethan A
EA
Department of Medical Education, Christus St. Joseph Hospital, 1401 Saint Joseph Parkway, Houston, Texas 77002, USA. natelson@pipeline.com
D000328:Adult; D001772:Blood Cell Count; D002884:Chromosomes, Human, Pair 15; D004781:Environmental Exposure; D005260:Female; D006798:Housing; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D010198:Pancytopenia / Q000175:diagnosis / Q000209:etiology; D010575:Pesticides; D014314:Trisomy
D010575:Pesticides