Recurrent glomerular diseases after renal transplantation.
BACKGROUND
Recurrent glomerular diseases are important causes of graft dysfunction after renal transplantation. As the outcomes of transplantation continue to improve, the problem of recurrent diseases in the transplanted kidney have become evident. The purpose of our study was to determine the risk factors for and the incidence of recurrence in the posttransplant period as well as their impact on graft survival rates.


METHODS
We retrospectively analyzed 49 patients with glomerular diseases due to membranoproliferative glomerulonephritis (n = 26); focal segmental glomerulosclerosis (FSGS, n = 18); and systemic lupus erythematosus (n = 5). The mean follow-up was 9.5 years.


RESULTS
Recurrent disease was detected in 30 of 49 patients after a mean posttransplant follow-up of 28.1 months (range = 1 to 157) and their average graft survival was 41.3 months. Nineteen patients were recurrence-free with a mean graft survival of 79.4 (range = 15 to 158) months (P < .05). One patient with FSGS, showed disease-recurrence in her third transplant after having experienced recurrences in the former grafts. In all six patients with HLA haplotype B8, recurrence was observed at a mean of 19.5 +/- 9.8 months. The only risk factor that was identified was this HLA haplotype.


CONCLUSIONS
Recurrent disease a significant problem after renal transplantation is associated with decreased graft survival. The donor HLA type may be associated with risk, which should be clearly discussed with both the living donor and the recipient candidate.
Karakayali
F Y
FY
Department of General Surgery, Başkent University, Faculty of Medicine, Ankara, Turkey.
Ozdemir
H
H
Kivrakdal
S
S
Colak
T
T
Emiroğlu
R
R
Haberal
M
M
D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000453:epidemiology*; D015432:Glomerulonephritis, Membranoproliferative / Q000453:epidemiology; D005923:Glomerulosclerosis, Focal Segmental; D006084:Graft Rejection / Q000453:epidemiology; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000601:surgery; D008297:Male; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors
D007166:Immunosuppressive Agents