The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models.
The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re.
Shin
Yong-Wook
YW
College of Pharmacy, Kyung Hee University, Seoul, Korea.
Bae
Eun-Ah
EA
Kim
Sung-Soo
SS
Lee
Young-Chul
YC
Lee
Boo-Young
BY
Kim
Dong-Hyun
DH
D000279:Administration, Cutaneous; D000818:Animals; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D036145:Ginsenosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008813:Mice, Inbred ICR; D010081:Oxazolone; D005894:Panax / Q000378:metabolism; D008517:Phytotherapy; D018517:Plant Roots; D013755:Tetradecanoylphorbol Acetate
D036145:Ginsenosides; D007641:Keratolytic Agents; D010081:Oxazolone; C049864:ginsenoside Re; C425564:ginsenoside Rh1; D013755:Tetradecanoylphorbol Acetate