Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.
Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
Cosgrove
Catherine A
CA
CMM (Infectious Diseases), St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom.
Castello-Branco
Luiz R R
LR
Hussell
Tracy
T
Sexton
Amy
A
Giemza
Rafaela
R
Phillips
Richard
R
Williams
Andrew
A
Griffin
George E
GE
Dougan
Gordon
G
Lewis
David J M
DJ
D000284:Administration, Oral; D000328:Adult; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007117:Immunization, Secondary; D007271:Injections, Intradermal; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology*
D016207:Cytokines; D014373:Tuberculin; D032581:Tuberculosis Vaccines