Intracranial stimulation study of lateralization of affect.
As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P=0.01) with right-sided stimulation (N=18) as compared with left-sided stimulation (N=3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.
Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA. jsmith@mail.mcg.edu
Joseph R
JR
Smith
Gregory P
GP
Lee
Kostas
K
Fountas
Don W
DW
King
Patrick D
PD
Jenkins
D000293:Adolescent; D000328:Adult; D002648:Child; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004644:Emotions; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000523:psychology / Q000601:surgery; D005059:Euphoria; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D016634:Radiosurgery; D012189:Retrospective Studies; D012640:Seizures / Q000473:pathology*