Human chromosome 11 DNA sequence and analysis including novel gene identification.
Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here--nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence--provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
Taylor
Todd D
TD
RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. taylor@gsc.riken.jp
Noguchi
Hideki
H
Totoki
Yasushi
Y
Toyoda
Atsushi
A
Kuroki
Yoko
Y
Dewar
Ken
K
Lloyd
Christine
C
Itoh
Takehiko
T
Takeda
Tadayuki
T
Kim
Dae-Won
DW
She
Xinwei
X
Barlow
Karen F
KF
Bloom
Toby
T
Bruford
Elspeth
E
Chang
Jean L
JL
Cuomo
Christina A
CA
Eichler
Evan
E
FitzGerald
Michael G
MG
Jaffe
David B
DB
LaButti
Kurt
K
Nicol
Robert
R
Park
Hong-Seog
HS
Seaman
Christopher
C
Sougnez
Carrie
C
Yang
Xiaoping
X
Zimmer
Andrew R
AR
Zody
Michael C
MC
Birren
Bruce W
BW
Nusbaum
Chad
C
Fujiyama
Asao
A
Hattori
Masahira
M
Rogers
Jane
J
Lander
Eric S
ES
Sakaki
Yoshiyuki
Y
D002880:Chromosomes, Human, Pair 11; D004247:DNA; D015870:Gene Expression; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D018035:Receptors, Odorant / Q000235:genetics; D017422:Sequence Analysis, DNA
D018035:Receptors, Odorant; D004247:DNA