[Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance].
OBJECTIVE
To compare the detection rate of Epstein-Barr virus latent membrane protein 1 (LMP1) 30 base pair deletion in extranodal nasal type NK/T-cell lymphoma with that in chronic inflammation of nasopharynx and tonsillitis; and to analyze the prognostic significance of LMP1 deletion in extranodal nasal type NK/T-cell lymphoma.


METHODS
Polymerase chain reaction was used to detect the deletion of LMP1 in 55 cases of extranodal nasal type NK/T-cell lymphoma and 19 cases of chronic inflammation of nasopharynx and tonsillitis. Follow-up information of 1 to 58-month duration was available in 33 patients.


RESULTS
In all the 55 extranodal nasal type NK/T-cell lymphoma cases studied, 9 cases contained the wide-type or predominantly wide-type LMP1. On the other hand, 46 cases contained the deleted or predominantly deleted LMP1. In the non-lymphoma control group, 16 cases contained the deleted or predominantly deleted LMP1. However, no statistically significant difference was found in the detection rate of 30 base pair deleted LMP1 between extranodal nasal type NK/T-cell lymphoma and control group (P > 0.05). The prognosis of deleted or predominantly deleted LMP1 in extranodal nasal type NK/T-cell lymphoma was worse.


CONCLUSIONS
Though 30 base pair deletion of Epstein-Barr virus LMP1 may not be an important pathogenetic step in extranodal nasal type NK/T-cell lymphoma, it may play some role in tumor progression.
Department of Pathology, West-China Hospital, Sichuan University, Chengdu 610041, China.
Sha
S
Zhao
Wei-Ping
WP
Liu
Xiao-Ling
XL
Wang
Wen-Yan
WY
Zhang
Wei
W
Jiang
Yuan
Y
Tang
Gan-Di
GD
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009304:Nasopharyngitis; D009669:Nose Neoplasms / Q000235:genetics* / Q000821:virology; D017384:Sequence Deletion; D015996:Survival Rate; D014069:Tonsillitis / Q000235:genetics / Q000821:virology; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000302:isolation & purification
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins