Properties of Allyl Alcohol-Resistant Mutants of Clostridium butyricum Grown on Glycerol.
Mutants of Clostridium butyricum E5 exhibiting resistance to allyl alcohol which produced the same quantities of 1,3-propanediol as the wild-type strain but more acetate than butyrate were isolated. The acetate-butyrate formation plays a major function in the regulation of the internal redox balance. Allyl alcohol resistance can be attributed not to the loss of 1,3-propanediol dehydrogenase but to a shift in the reductive properties of the enzyme. The data support the view that cellular regulation is modified to avoid intracellular accumulation of 3-hydroxypropionaldehyde.
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S
Abbad-Andaloussi
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J
Amine
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P
Gerard
E
E
Petitdemange
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H
Petitdemange