[Preliminary quantitative study of dynamic magnetic resonance diffusion tensor imaging in rabbit models implanted with hepatic tumor grafts from VX2].
OBJECTIVE
To investigate the feasibility of dynamic magnetic resonance diffusion tensor imaging (DTI) in rabbit models with implanted VX2 hepatic tumor grafts.


METHODS
MRI and DTI images were obtained from 16 rabbit models with implanted VX2 hepatic tumor grafts (14, 18, 22, and 26 days after tumor implantation, respectively) and 4 normal rabbits. The average diffusion coefficient (ADC) and exponential ADC (eADC) were estimated and compared against pathological findings.


RESULTS
The ADC values increased after tumor implantation but then decreased in the rabbit models, whereas eADC exhibited a pattern of reverse changes. These changes significantly differed from those in the control group. Coagulation necrosis and fibrous hyperplasia showed obvious increase as found by pathological examination.


CONCLUSIONS
Dynamic MR DTI quantitative analysis of rabbit models of implanted VX2 hepatic tumor can partially describe the growth behaviors of implanted liver cancer.
Xu
Shao-bin
SB
Imaging Center, Pingzhou Hospital, Foshan 528251, China. fsxusb@yahoo.com.cn
Quan
Xian-yue
XY
Sun
Xi-jie
XJ
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007089:Image Enhancement / Q000379:methods*; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009368:Neoplasm Transplantation; D011817:Rabbits; D011897:Random Allocation