[Genetics and molecular biology of the congenital, and acquired heart disease].
The heart is the first organ to form and function in the embryo, and all subsequent events in the life of the organism depend on the heart's ability to match its output with the organism's demands for oxygen and nutrients. Abnormalities in heart formation, the most common form of human birth defects, afflict nearly 1% of newborns, and their frequency in spontaneously aborted pregnancies is estimated to be tenfold higher. With the completion of the sequencing of the human genome, molecular genetic efforts directed at finding genes for monogenic traits have accelerated dramatically. Breakthroughs in molecular genetic technology have just begun to be applied in pediatric cardiology stemming from the use of chromosomal mapping and the identification of genes involved in both the primary etiology and as significant risk factors in the development of cardiac and vascular abnormalities. This review will focus on information provided by molecular and genetic analysis in the diagnosis, treatment and overall heart disorders.
Departamento de Patología, Instituto Nacional de Cardiología, Ignacio Chávez, Tlalpan, México, DF. crumis@hotmail.com
David
D
Cruz Robles
Aurora
A
de la Peña Díaz
Minerva
M
Arce Fonseca
José de Jesús
Jde J
García Trejo
Oscar A
OA
Pérez Méndez
Gilberto
G
Vargas Alarcón
D006331:Heart Diseases / Q000151:congenital* / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008967:Molecular Biology; D025202:Molecular Diagnostic Techniques