In Vitro and In Vivo preparation evaluations of bleomycin implants and microspheres Prepared with DL-poly (lactide-co-glycolide).
In this investigation, poly(lactide-co-glycolide) (PLGA) gel implants and microspheric depot systems of bleomycin (BLM) were formulated and evaluated in vivo in mice bearing transplantable solid tumor (fibrosarcoma). The pharmacodynamic studies showed that both the formulations retarded tumor growth significantly (p<0.05) when compared to the control animals (without any drug treatment). Preliminary pharmacokinetic studies illustrated controlled release of the drug into the systemic circulation to elicit the anti-neoplastic action. The gel implants showed better release characteristics and greater pharmacodynamic action when compared to the microspheres, thus demonstrating the feasibility of employing biodegradable depot polymer gel matrix for chronic cancer therapy.
Manipal College of Pharmaceutical Sciences, Manipal, 576 104, Karnataka, India. souzaresh@rediffmail.com
R
R
D'Souza
S
S
Mutalik
N
N
Udupa
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005354:Fibrosarcoma / Q000188:drug therapy; D005782:Gels; D051379:Mice; D008863:Microspheres; D009368:Neoplasm Transplantation; D010316:Particle Size; D011098:Polyglactin 910 / Q000737:chemistry*; D012995:Solubility
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005782:Gels; D001761:Bleomycin; D011098:Polyglactin 910