Drug-associated organizing pneumonia: high-resolution CT findings in 9 patients.
OBJECTIVE
To assess the high-resolution computed tomography appearances of drug-associated organizing pneumonia (OP).


METHODS
Nine patients with clinical and biopsy proven drug-associated OP were included in the study. High-resolution computed tomography exams were retrospectively reviewed by 2 observers for the presence, extent, and distribution of parenchymal abnormalities.


RESULTS
The commonest findings consisted of air space consolidation (n = 8) and ground-glass opacification (n = 7). The air space consolidation was bilateral and asymmetric in 7 patients, symmetric in 1 patient and in all cases involved mainly the peribronchial or subpleural regions or both. The ground-glass opacities were predominantly bilateral and asymmetric in 6 patients and unilateral in 1 patient. They had a patchy distribution in 4 patients, were diffuse in 2 patients, and subpleural in 1 patient.


CONCLUSIONS
Drug-associated OP most commonly presents with bilateral, asymmetrical air space consolidation in a predominantly peribronchial and subpleural distribution.
Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Jonathan D
JD
Dodd
Kyung Soo
KS
Lee
Takeshi
T
Johkoh
Nestor L
NL
Müller
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006571:Heterocyclic Compounds / Q000009:adverse effects; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009588:Nitrogen Mustard Compounds / Q000009:adverse effects; D015588:Observer Variation; D011014:Pneumonia / Q000139:chemically induced / Q000175:diagnosis*; D012189:Retrospective Studies; D013752:Tetracycline / Q000009:adverse effects; D014057:Tomography, X-Ray Computed / Q000379:methods*
D006571:Heterocyclic Compounds; D009588:Nitrogen Mustard Compounds; D013752:Tetracycline