Positive family history promotes participation in colorectal cancer screening.
BACKGROUND
Participation rates in colorectal cancer (CRC) screening are rather low. We evaluated the interest of first degree relatives (FDR) of CRC patients to participate in a colonoscopy screening and compared the findings to controls with a negative family history.


METHODS
There were 235 CRC patients diagnosed in our centre in 1984-2001. These were mailed an invitation letter for a preventive examination for their FDR older than 40 years and a questionnaire about occurrence of malignancies in their family. Colonoscopy was performed in 52 FDR and sex/age matched controls.


RESULTS
The questionnaire was delivered to 196 patients. Thirty four (17.3%) patients responded. Positive family history for CRC was reported in 12/34 (35.3%) patients, compared to expected 3.4 patients (p = 0.04; OR 4.2; 95% CI = 1.05-17.89). Fifty two of 94 (55.3%) FDR participated in a screening and CRC was diagnosed in 2 and CRA in 18 patients compared to 1 CRC and 9 CRA in control group (p = 0.04; Kaplan-Meier p = 0.04).


CONCLUSIONS
Positive family history seems to be a motivation factor for a participation in a CRC screening program. Consistent with previous studies the prevalence of CRA and CRC was significantly higher in the group of FDR compared to controls (Tab. 3, Fig. 1, Ref. 20).
1st Department of Internal Medicine, University Hospital, Comenius University, Bratislava, Slovakia. tibor.hlavaty@zoznam.sk
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Hlavaty
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Lukac
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Huorka
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Bezayova
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Duris
D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010342:Patient Acceptance of Health Care