Blockage of PI3K/PKB/P27kip1 signaling pathway can antagonize 17 beta-estradiol-induced Ishikawa proliferation and cell cycle progression.
Department of Gynecology, People's Hospital, Peking University, BeijinG 100044, China.
Rui-xia
RX
Guo
Li-hui
LH
Wei
Yu-huan
YH
Qiao
Jian-liu
JL
Wang
Jian-min
JM
Tang
D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000037:antagonists & inhibitors* / Q000502:physiology; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D009025:Morpholines / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
D002867:Chromones; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004958:Estradiol; D047908:Intracellular Signaling Peptides and Proteins; D009025:Morpholines; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; C436291:CDKN1B protein, human; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one