[Severe chloralose intoxication in a toddler].
We report a case of an accidental intoxication in a 20-month-old boy resulting from the ingestion of a rodenticide containing alpha-chloralose.


METHODS
Three hours after initial admission to the pediatric emergency department for wheezing bronchitis, this patient was readmitted with a clinical presentation of respiratory insufficiency, a Glasgow coma score of 9 alternating with agitation, areflexia and unilateral mydriasis. Parental interview revealed he had episodes of shaking in the afternoon. Chest x-ray showed thoracic distension. Blood investigations, electrocardiogram, cardiac echography, brain CT scan and CSF were normal. Electroencephalography registered slow delta waves 2-3 cycles/min and an aspect of degraded waves and spikes. The patient was transferred to the intensive care unit where he fully recovered within 48 hours. A second parental interview and clinical presentation confirmed an intoxication with a rodenticide containing alpha-chloralose. The late clinical orientation did not allow us to perform a urinanalysis.


CONCLUSIONS
Clinical association of coma, spontaneous or triggered myoclonias and bronchial hypersecretion are indicative of chloralose intoxication. Presence of specific abnormalities on electroencephalogram and a positive Fujiwara-Ross reaction in an urine sample are additional elements for the diagnosis. The prognosis is usually good after early management which combines gastric lavage, activated charcoal, sedation with benzodiazepines, tracheal intubation and artificial ventilation if required. Severe clinical cases described in voluntary intoxications in adults and teenagers occur very rarely in toddlers.
Federici
S
S
Posu Pédiatrique, Hôpital des Enfants, CHU de Toulouse, 330, avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse cedex 09, France.
Claudet
I
I
Laporte-Turpin
E
E
Marcoux
M O
MO
Cheuret
E
E
Maréchal
K
K
D000059:Accidents; D002698:Chloralose / Q000009:adverse effects* / Q000032:analysis; D003128:Coma / Q000139:chemically induced; D062787:Drug Overdose; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D006801:Humans; D007223:Infant; D008297:Male; D015878:Mydriasis / Q000139:chemically induced; D012021:Reflex, Abnormal; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012378:Rodenticides / Q000009:adverse effects* / Q000737:chemistry
D012378:Rodenticides; D002698:Chloralose