Modulation of lymphocyte migration to the murine spleen after marginal zone macrophage phagocytosis of blood-borne particulate material.
Our previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocyte Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity.
Bruce Lyons
A
A
Division of Haematology and Hanson Institute, The Institute of Medical and Veterinary Science, Adelaide, SA, Australia. Bruce.Lyons@imvs.sa.gov.au
Watkins
Marcus
M
Simpson
Campbell C
CC
Konrad Muller
H
H
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002244:Carbon / Q000097:blood / Q000276:immunology; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000235:genetics; D004338:Drug Combinations; D005260:Female; D007156:Immunologic Memory; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D011205:Povidone; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D015854:Up-Regulation
D054382:Chemokine CXCL13; D019743:Chemokines, CXC; C486386:Cxcl13 protein, mouse; D004338:Drug Combinations; D012333:RNA, Messenger; C078073:carbon colloid; D002244:Carbon; D011205:Povidone