[Pulmonary mucormycosis in a multiple-trauma patient].
Mucormycosis are opportunist infections occurring usually among predisposed patients. We report a case of an 18-year-old male with a severe thoracic trauma who developed an Absidia infection on his contused pulmonary parenchyma, without presenting the usual risk factors (diabetes mellitus, immunodeficiency). The early diagnosis using bronchoscopy has probably improved the outcome by allowing a faster treatment. After 18-months, the infectious process resolved thanks to a combination of a medical treatment composed of high-dose amphotericin B lipid formulation, itraconazole and a complementary surgical treatment.
Grandin
W
W
Département d'Anesthésie-Réanimation Chirurgicale-Samu, Centre Hospitalier Régional et Universitaire de Caen, avenue de la Côte-de-Nacre, 14033 Caen cedex, France. Grandinws@aol.com
Dessieux
T
T
Hounfodji
P
P
Viquesnel
G
G
Ouchikhe
A
A
Gérard
J-L
JL
D020095:Absidia / Q000302:isolation & purification*; D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001642:Bicycling / Q000293:injuries; D001925:Brain Damage, Chronic / Q000209:etiology; D001930:Brain Injuries / Q000150:complications; D001933:Brain Stem / Q000098:blood supply; D002543:Cerebral Hemorrhage / Q000209:etiology; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008169:Lung Abscess / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D009104:Multiple Trauma / Q000150:complications*; D011013:Pneumonectomy / Q000379:methods; D013898:Thoracic Injuries / Q000150:complications; D014640:Vancomycin / Q000627:therapeutic use
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D014640:Vancomycin; D000666:Amphotericin B