Focal segmental glomerulosclerosis associated with essential thrombocythemia.
Focal segmental glomerulosclerosis (FSGS) is a primary glomerular disease that is characterized by progressive proteinuria and declining renal function. Secondary FSGS is known to be associated with various diseases. However, an association of FSGS with essential thrombocythemia (ET) has been reported in few cases. We report a 76-year-old man who presented with nephrotic syndrome and hepatosplenomegaly. He had thrombocythemia after a splenectomy, which had been carried out at a nearby hospital. A renal biopsy showed that he had focal segmental glomerulosclerosis (FSGS), while assessment of the bone-marrow specimen revealed that he had ET. A possible relationship between FSGS, which occurred in association with a dramatic increase of thrombocytes after a splenectomy in a patient with ET, and increased serum levels of transforming growth factor (TGF)-beta, basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF)-BB was suggested.
Haraguchi
Kazutaka
K
Third Department of Internal Medicine, University of Yamanashi, 1110 Tamaho, Nakakoma, Yamanashi 409-3898, Japan. kazutaka@res.yamanashi-med.ac.jp
Shimura
Hiroki
H
Ogata
Ryouji
R
Inoue
Hironobu
H
Saito
Takehiro
T
Kondo
Tetsuo
T
Nagata
Michio
M
Kobayashi
Tetsuro
T
D000368:Aged; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006133:Growth Substances / Q000097:blood; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D013156:Splenectomy / Q000009:adverse effects; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000473:pathology
D006133:Growth Substances