[Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
Metabolic syndrome (MS) is a worldwide medical problem characterized by a cluster of cardiovascular risk factors and metabolic modifications involving peripheral insulin resistance. Nonalcoholic steatohepatitis (NASH) represents the liver expression of this pathological condition. Both MS and NASH are characterized by proinflammatory status and increased oxidative stress. According this, we aimed to review the literature for considering a possible role for vitamins as therapeutical support in MS and NASH.
Miele
Luca
L
Istituto di Medicina Interna e Geriatria, Policlinico Gemelli, Università Cattolica del Sacro Cuore, Roma.
Gabrieli
Maria L
ML
Forgione
Alessandra
A
Vero
Vittoria
V
Gallo
Antonella
A
Capristo
Esmeralda
E
Gasbarrini
Giovanni
G
Grieco
Antonio
A
D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006505:Hepatitis / Q000150:complications / Q000378:metabolism*; D006710:Homocysteine / Q000494:pharmacology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D012307:Risk Factors; D000077385:Silybin; D012838:Silymarin / Q000627:therapeutic use; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D012838:Silymarin; D014815:Vitamins; D006710:Homocysteine; D014807:Vitamin D; D000077385:Silybin; D005492:Folic Acid; D014805:Vitamin B 12