Prevention of postoperative recurrence of Crohn's disease by infliximab.
The prevention of the recurrence of Crohn's disease after surgery remains difficult. The monoclonal antibody anti-TNF-alpha, infliximab, is very effective in inducing and maintaining the remission of uncomplicated, active Crohn's disease. We present here the case of a 23-year-old white woman who underwent resection for a sigmoid stricture caused by Crohn's disease. Surgery removed the involved colon, and pathology confirmed the stricture to be fibrotic. Two weeks after the operation she was given infliximab at the dose of 5 mg/kg body weight and followed in time. Since then, she has been disease free for approximately 4 years after surgery on clinical, radiological and endoscopic/histological grounds (Crohn's Disease Activity Index < or = 110 on all occasions). Up to now, she has had no increase in inflammatory indices, no anaemia and no abnormal blood tests. In contrast, all of five control patients operated in the same period with colonic or ileocolonic resection for symptomatic strictures and treated with mesalamine or no medication developed endoscopic or clinical recurrence (abdominal pain or diarrhoea) by year 3. This is the first case, to our knowledge, in which infliximab has been successfully used to prevent the postsurgical recurrence of Crohn's disease, an event so far considered to be inescapable. We believe that, with this aim in mind, clinical trials with this drug are warranted.
Sorrentino
Dario
D
GI Unit, Internal Medicine, Department of Clinical and Experimental Pathology, University of Udine School of Medicine, Udine, Italy. sorrentino@uniud.it
Terrosu
Giovanni
G
Avellini
Claudio
C
Beltrami
Carlo A
CA
Bresadola
Vittorio
V
Toso
Francesco
F
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000517:prevention & control*; D005260:Female; D006801:Humans; D000069285:Infliximab; D011183:Postoperative Complications / Q000517:prevention & control*; D055502:Secondary Prevention; D012810:Sigmoid Diseases / Q000209:etiology / Q000601:surgery
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab