Genetic knowledge and moral responsibility: ambiguity at the interface of genetic research and clinical practice.
Despite a rapidly expanding literature on the issue of duty to warn at-risk relatives in the context of clinical genetic testing, little has been written on parallel issues with regard to the management of genetic research results. Some might view this lack as an indication that there is little to discuss in this regard. That is, standard practice is that data obtained through medical research should not be treated as though they are clinically relevant, and this standard should hold for genetic research as well. This paper challenges this conclusion and its underlying assumptions. We argue that the line between genetic research and clinical practice is often ambiguous. In some cases, research data gathered from a very small number of subjects could have immediate clinical implications. Hence, it is unethical for genetic researchers to absolve themselves of clinical responsibilities for research subjects and/or their families, on the grounds that the data were obtained for research purposes. Indeed, we argue that it could well be unethical to embark on some forms of genetic research unless advance arrangements have been made for genetic counseling and clinical follow-up. Furthermore, in some cases, it might be unethical to enroll subjects in studies if the subjects are unwilling to receive their individual results.
Pullman
D
D
Medical Ethics, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada A1B 3V6. dpullman@mun.ca
Hodgkinson
K
K
D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000235:genetics; D009202:Cardiomyopathies / Q000235:genetics; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D017007:Duty to Warn; D005260:Female; D005799:Genes, Dominant; D005817:Genetic Counseling; D005820:Genetic Testing; D005826:Genetics, Medical / Q000941:ethics*; D006801:Humans; D007258:Informed Consent; D008297:Male; D028681:Moral Obligations; D009523:Newfoundland and Labrador; D018497:Ventricular Dysfunction, Right / Q000235:genetics