Screening for Y microdeletions in men with testicular cancer and undescended testis.
OBJECTIVE
To investigate a possible association between testicular cancer or undescended testis and Y microdeletions.


METHODS
It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions.


RESULTS
A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively.


CONCLUSIONS
Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.
Bor
Pinar
P
Fertility Clinic, Aarhus, Denmark. pinarbor@yahoo.com
Hindkjaer
Johnny
J
Kølvraa
Steen
S
Rossen
Philip
P
von der Maase
Hans
H
Jørgensen
Troels Munch
TM
Sørensen
Viggo Tønning
VT
Eiberg
Hans
H
Ingerslev
Hans Jakob
HJ
D000328:Adult; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D003456:Cryptorchidism / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000235:genetics*