Solid-supported acids for debenzylation of aryl benzyl ethers.
Solid-supported acids have been investigated for aromatic debenzylation reactions. Stoichiometric amounts of solid-supported acids in refluxing toluene with or without 4 equiv of methanol effectively provided the desired aromatic debenzylation products of various systems in moderate to excellent yields (up to 98%).
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand.
Thaninee
T
Petchmanee
Poonsakdi
P
Ploypradith
Somsak
S
Ruchirawat
D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001593:Benzyl Compounds / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D012117:Resins, Synthetic / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D000498:Allyl Compounds; D001593:Benzyl Compounds; D004952:Esters; D007202:Indicators and Reagents; D012117:Resins, Synthetic; D012997:Solvents