[Preliminary data on post-pancreatectomy diabetes mellitus treated by islet-cell autotransplantation].
The present study describes the first islet autotransplant program in Romania, and the first 3 cases of subtotal pancreatectomy for chronic pancreatitis combined with islet autotransplant. The primary objective was to pain relief by pancreatic resection, but also to preserve the endocrine function by islet autotransplant. Extensive distal pancreatectomy is effective in relieving pain, but should be limited to patients with small duct disease, in whom more conservative methods have failed, because of severe metabolic consequences. Islets were prepared by Liberase digestion of the excised pancreas, and infused unpurified into the portal vein in one case and in the omental pouch and peritoneum in two cases. All patients were relieved of pain, have achieved insulin independence, and positive C peptide levels, but one patient died of a acute bronchopneumonia 60 days post-transplantation. The mean islet yields were 2100 islet equivalents/Kg body weight. Islet autotransplantation can be considered a useful therapeutic option serving to prevent the occurrence of surgically-induced diabetes. The results have indicate that the omental pouch is a viable site for islet autotransplantation, that can accommodate a large tissue volume, is easy to access to implant, and the IBMIR (instant blood mediated inflammatory reaction) may be less severe.
Sârbu
V
V
Chirurgie Generală, Universitatea Ovidius Constanta, Facultatea de Medicină Generală.
Dima
S
S
Aşchie
M
M
Balaban
D
D
Ghelberg
M
M
Grasa
C
C
Botea
F
F
Pasăre
R
R
Nicolae
G
G
Popescu
R
R
D000328:Adult; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects*; D010195:Pancreatitis / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome