Oxygen plasma surface modification enhances immobilization of simvastatin acid.
Simvastatin acid (SVA) has been reported to stimulate bone formation with increased expression of BMP-2. Therefore, immobilization of SVA onto dental implants is expected to promote osteogenesis at the bone tissue/implant interface. The aim of this study was to evaluate the immobilization behavior of SVA onto titanium (Ti), O(2)-plasma treated titanium (Ti + O(2)), thin-film coatings of hexamethyldisiloxane (HMDSO), and O(2)-plasma treated HMDSO (HMDSO + O(2)) by using the quartz crystal microbalance-dissipation (QCM-D) technique. HMDSO surfaces were activated by the introduction of an OH group and/or O(2)-functional groups by O(2)-plasma treatment. In contrast, titanium surfaces showed no appreciable compositional changes by O(2)-plasma treatment. The QCM-D technique enabled evaluation even at the adsorption behavior of a substance with a low molecular weight such as simvastatin. The largest amount of SVA was adsorbed on O(2)-plasma treated HMDSO surfaces compared to untreated titanium, HMDSO-coated titanium, and O(2)-plasma treated titanium. These findings suggested that the adsorption of SVA was enhanced on more hydrophilic surfaces concomitant with the presence of an OH group and/or O(2)-functional group resulting from the O(2)-plasma treatment, and that an organic film of HMDSO followed by O(2)-plasma treatment is a promising method for the adsorption of SVA in dental implant systems.
Department of Dental Materials Science, Oral Health Science Center, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. yosinari@tdc.ac.jp
Masao
M
Yoshinari
Tohru
T
Hayakawa
Kenichi
K
Matsuzaka
Takashi
T
Inoue
Yutaka
Y
Oda
Masaki
M
Shimono
Takaharu
T
Ide
Teruo
T
Tanaka
D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry; D019821:Simvastatin / Q000031:analogs & derivatives* / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D012833:Siloxanes; C063287:simvastatin acid; D019821:Simvastatin; D014025:Titanium; C015917:hexamethyldisiloxane; D010100:Oxygen