No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus.
Xiong
Yue
Y
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. yxiong@email.unc.edu
Kotake
Yojiro
Y
D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics; D003593:Cytoplasm / Q000378:metabolism; D017491:Genes, APC; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006801:Humans; D011496:Protein Methyltransferases; D015398:Signal Transduction; D015533:Transcriptional Activation; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000037:antagonists & inhibitors*
D002843:Chromatin; D051153:Wnt Proteins; D051176:beta Catenin; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase