Synthesis and characterization of Fe(III) and Pb(ll) complexes with 3-hydroxypyridine-2(1H)-thiones.
Two kinds of 3-hydroxypyridine-2(1H)-thiones were synthesized. The visible (VIS) spectroscopic analysis indicated that 3-hydroxy-1-methylpyridine-2(1H)-thione (4a) and 3-hydroxy-1-(2-hydroxyethyl)pyridine-2(1H)-thione (4b) formed stable 3:1 Fe(III) complexes. The stability constant of the 4b-Fe(III) complex was estimated from the competitive reaction with EDTA and was found to be 36.7 in logbeta3. Treatment of compound 4b with Ga(acac)3 in D2O:CD3OD (9:1) solution afforded 3:1 Ga(Ill) complex, which was assigned by means of 1H nuclear magnetic resonance (1H NMR) spectroscopy. Treatment of compound 4b with Pb(NO3)2 gave 4b-Pb(II) complex. The Pb(II) selectivity over biologically relevant Mg(ll) and Ca(ll) was remarkably improved by adopting N-hydroxyethyl functionality instead of N-methyl group.
Katoh
Akira
A
Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo, Japan. katoh@st.seikei.ac.jp
Harada
Koichi
K
Saito
Ryota
R
D005708:Gallium / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D013871:Thiones / Q000737:chemistry*
D009942:Organometallic Compounds; D011725:Pyridines; D013871:Thiones; D007854:Lead; D005708:Gallium; D007501:Iron