Influence of a GABA(B) and GABA(C) receptor antagonist on sleep-waking cycle in the rat.
This study tested the influence of CGP 36742, a both gamma-aminobutyric acid(B) (GABA(B)) and GABA(C) receptor antagonist, on sleep and waking. The compound was injected intraperitoneally at 1, 10, 30, 100, 300 and 500 mg/kg to rats which were recorded during 6 h. Only at 500 mg/kg, total waking was increased during third and fourth hours and total duration of recording by a specific enhancement of quiet waking (without hippocampal theta activity). Slow wave sleep was decreased at 100, 300, 500 mg/kg during the third and fourth hours, and during total recording time at 500 mg/kg. Paradoxical sleep was not affected. While it was not possible to distinguish already known GABA(B) and GABA(C) identical influence on waking and slow wave sleep, their previously shown opposite effect on paradoxical sleep seemed to nullify each other.
Laboratoire de Neurobiologie et Psychopathologie, Faculté des Sciences, Université de Nice-Sophia Antipolis, Nice, France.
Olivier
O
Deschaux
Wolfgang
W
Froestl
Claude
C
Gottesmann
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D018756:GABA Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000502:physiology; D018080:Receptors, GABA-B / Q000502:physiology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D013826:Theta Rhythm / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D018756:GABA Antagonists; C087200:GABA-C receptor; D009943:Organophosphorus Compounds; D018079:Receptors, GABA; D018080:Receptors, GABA-B; C079148:(3-aminopropyl)(n-butyl)phosphinic acid