[Applications of a rat model of chronic bronchitis on toxicity of PM2.5].
OBJECTIVE
To study the acute toxicity of PM2.5 to the rats with chronic bronchitis and the control rats and the difference between the model rats and the control rats on PM2.5 toxicity.


METHODS
With the use of an intratracheal instillation, both groups were exposed to suspensions of PM2.5. After three times, the levels of ALB, LDH, AKP, MDA and GSH in bronchoalveolar lavage fluid (BALF) were analyzed.


RESULTS
PM2.5 could induce the acute toxicity to both model rats and control rats, and dose-response relationships were observed in all indexes. In model rats, the levels of ALB, LDH, AKP, and MDA were higher in control rats( P < 0.05), while the levels of GSH were lower in control rats (P < 0.05).


CONCLUSIONS
PM2.5 could have acute toxic effects on both model rats and health rats, and the rats with chronic bronchitis are more susceptible to PM2.5 than health rats.
School of Public Health of Fudan University, Shanghai 200032, China.
Qiang
Q
Cao
Wei-min
WM
Song
Si-ya
SY
A
Li-na
LN
Tao
D000393:Air Pollutants / Q000633:toxicity*; D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D029481:Bronchitis, Chronic / Q000139:chemically induced*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D019570:Inhalation Exposure / Q000009:adverse effects*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008168:Lung / Q000473:pathology; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D051381:Rats
D000393:Air Pollutants; D000418:Albumins; D052638:Particulate Matter; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase