Magnetic resonance spectroscopy detects biochemical changes in the brain associated with chronic low back pain: a preliminary report.
Magnetic resonance (MR) spectroscopy is a noninvasive technique that can be used to detect and measure the concentration of metabolites and neurotransmitters in the brain and other organs. We used in vivo (1)H MR spectroscopy in subjects with low back pain compared with control subjects to detect alterations in biochemistry in three brain regions associated with pain processing. A pattern recognition approach was used to determine whether it was possible to discriminate accurately subjects with low back pain from control subjects based on MR spectroscopy. MR spectra were obtained from the prefrontal cortex, anterior cingulate cortex, and thalamus of 32 subjects with low back pain and 33 control subjects without pain. Spectra were analyzed and compared between groups using a pattern recognition method (Statistical Classification Strategy). Using this approach, it was possible to discriminate between subjects with low back pain and control subjects with accuracies of 100%, 99%, and 97% using spectra obtained from the anterior cingulate cortex, thalamus, and prefrontal cortex, respectively. These results demonstrate that MR spectroscopy, in combination with an appropriate pattern recognition approach, is able to detect brain biochemical changes associated with chronic pain with a high degree of accuracy.
Pain Management Research Institute, University of Sydney, Royal North Shore Hospital, St. Leonards NSW, Australia. phils@med.usyd.edu.au
Philip J
PJ
Siddall
Peter
P
Stanwell
Annie
A
Woodhouse
Ray L
RL
Somorjai
Brion
B
Dolenko
Alexander
A
Nikulin
Roger
R
Bourne
Uwe
U
Himmelreich
Cynthia
C
Lean
Michael J
MJ
Cousins
Carolyn E
CE
Mountford
D001921:Brain / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism; D006801:Humans; D017116:Low Back Pain / Q000175:diagnosis* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010147:Pain Measurement / Q000379:methods; D017397:Prefrontal Cortex / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism