Low temperature decreased tension in isolated hypertrophic human nasal mucosa.
BACKGROUND
The purpose of this study was to evaluate the effect of low temperature on basal tension in isolated hypertrophic human nasal mucosa with or without alpha1-agonist stimulation.


METHODS
A tissue bath for isolated nasal mucosa was used. Tension in strips of human turbinate mucosa that were untreated and treated with an alpha1-adrenoreceptor agonist, methoxamine (10 microM), was recorded continuously in a stepwise manner in temperatures that varied from 37 to 10 degrees C.


RESULTS
The changes of tension in the human nasal mucosa were found to be temperature-dependent in both untreated and treated tissues, with tension decreasing to 48.6% at 10 degrees C in comparison with 100% at 37 degrees C in the untreated group, the presence of methoxamine (10 microM) had minimal effect.


CONCLUSIONS
Low temperature induced a rapid and reproducible relaxation in isolated hypertrophic human nasal mucosa that was not affected by the presence of the alpha1-agonist methoxamine (10 microM).
Graduate Institute of Medical Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Yueng-Hsiang
YH
Chu
Chin-Chen
CC
Wu
Chuan-Hsiang
CH
Kao
Hsing-Won
HW
Wang
D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D003080:Cold Temperature; D005069:Evaluation Studies as Topic; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology* / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D014662:Vasoconstrictor Agents; D008729:Methoxamine