Lipodystrophy is an independent predictor of hypertriglyceridemia during pregnancy in HIV-infected women.
Lipid values were measured during pregnancy in HIV-infected, treatment-experienced women. A previous history of lipodystrophy was associated with significantly higher triglyceride values at all pregnancy trimesters. In multivariate analyses lipodystrophy independently increased the risk of hypertriglyceridemia by threefold at the first trimester, and by eightfold at the second and third trimesters. Protease inhibitor treatment was also independently associated with hypertriglyceridemia.
Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Rome.
Marco
M
Floridia
Giovanni
G
Guaraldi
Enrica
E
Tamburrini
Cecilia
C
Tibaldi
Anna
A
Bucceri
Gianfranco
G
Anzidei
Alessandra
A
Meloni
Antonella
A
Vimercati
Cosimo
C
Polizzi
Ernesto Renato
ER
Dalle Nogare
Salvatore
S
Alberico
Marina
M
Ravizza
D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D017320:HIV Protease Inhibitors; D014280:Triglycerides; D002784:Cholesterol