Increased interferon production in human cells irradiated with ultraviolet light.
Polyinosinate-polycytidylate [poly(I).poly(C)]-induced interferon production in cultures of human foreskin fibroblast strains was increased by ultraviolet irradiation of cells at the time of exposure to inducer or at 2 h after induction. Incubation of cells with interferon prior to induction (priming) and ultraviolet irradiation exerted a cooperative enhancing effect on interferon production. The resulting interferon yields were generally somewhat higher than the yields from cultures subjected to sequential treatment with cycloheximide and actinomycin D.
Mozes
L W
LW
Department of Microbiology, New York University School of Medicine, New York, New York 10016.
Havell
E A
EA
Gradoville
M L
ML
Vilcek
J
J