[Immunological aspects of atherosclerosis].
The pathogenesis of atherosclerosis remains incompletely understood. Accumulation of oxidized lipoproteins (oxLDL) within the vascular wall drives a related immune response very early during the disease course. Such an immune response is self-amplified and eventually escapes from physiologic control mechanisms. Certain lymphocytes may become pathogenic. B cells play a protective role by producing antibodies able to neutralize oxLDL. Elucidation of the immune control mechanisms in atherosclerosis will open the way to new therapeutic perspectives.
Groyer
Emilie
E
Inserm U681, Université Pierre et Marie Curie - Paris VI, Institut des Cordeliers.
Caligiuri
Giuseppina
G
Laschet-Khallou
Jamila
J
Nicoletti
Antonino
A
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D001057:Apolipoproteins E / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology*; D003324:Coronary Artery Disease / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D017152:Antibodies, Antiphospholipid; D001057:Apolipoproteins E; D015704:CD4 Antigens; D016207:Cytokines; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D007371:Interferon-gamma