Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression.
CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Ralpha expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.
Department of Molecular Microbiology and Immunology, School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Alexandre
A
Morrot
Ian A
IA
Cockburn
Michael
M
Overstreet
Dolores
D
Rodríguez
Fidel
F
Zavala
D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism* / Q000637:transplantation; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D007156:Immunologic Memory / Q000235:genetics; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000235:genetics; D018655:Lymphocyte Count; D008288:Malaria / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D017780:Malaria Vaccines / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D010967:Plasmodium yoelii / Q000254:growth & development / Q000276:immunology*; D011237:Predictive Value of Tests; D020395:Receptors, Interleukin-7 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
D017780:Malaria Vaccines; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain