Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease.
Dementia from Alzheimer's disease (AD) represents a significant and growing public health burden and presents a clear therapeutic imperative. Key to success in this undertaking will be biomarkers for the objective assessment of disease progression and response to therapeutics. Oxidative damage is one facet of AD pathogenesis for which there are experimentally validated quantitative in vivo biomarkers, the F2-isoprostanes (IsoPs). While plasma- or urine-based assays are desirable, consistent and reproducible cross-sectional data for increased F2-IsoPs in AD and mild cognitive impairment have been obtained only for CSF. In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD.
Montine
Thomas J
TJ
Department of Pathology, University of Washington, Seattle, WA 98104, USA. tmontine@u.washington.edu
Quinn
Joseph F
JF
Montine
Kathleen S
KS
Kaye
Jeffrey A
JA
Breitner
John C S
JC
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000517:prevention & control*; D001057:Apolipoproteins E / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis; D003704:Dementia / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000517:prevention & control; D028441:F2-Isoprostanes / Q000134:cerebrospinal fluid; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors
D001057:Apolipoproteins E; D015415:Biomarkers; D028441:F2-Isoprostanes