Association of the Tau haplotype with Parkinson's disease in the Greek population.
We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation.
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr
Liana
L
Fidani
Kallirhoe
K
Kalinderi
Sevasti
S
Bostantjopoulou
Jordi
J
Clarimon
Antonis
A
Goulas
Zoe
Z
Katsarou
John
J
Hardy
Alexandros
A
Kotsis
D000368:Aged; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012016:Reference Values; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins