[Role of cytokines in immune response to T-independent antigens, type 2].
The influence of human and mouse cytokines on the induction of immune response to model T-independent (TI) antigens of type 2--DNP-dextran and DNP-ficoll--in the culture of mouse spleen cells was studied. For the first time this study revealed that the action of definite T-cell factors not only induced the polyclonal stimulation of B lymphocytes, but also the increased synthesis of specific antibodies, as well as switched over antibody isotypes from IgM to IgG. This confirmed the suggestion that T cells took part (directly or indirectly) in the regulation of immune response to so-called TI antigens. These results widened our knowledge on the mechanisms of the development of humoral immune response to TI antigens of type 2.
Borisova
T K
TK
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity; D000955:Antigens, T-Independent / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D005260:Female; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology
D000906:Antibodies; D000955:Antigens, T-Independent; D016207:Cytokines