Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis.
For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus (SARS-CoV) was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines.
Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Peng
P
Shi
Li
L
Yu
Yun-Xin
YX
Fu
Jing-Fei
JF
Huang
Ke-Qin
KQ
Zhang
Ya-ping
YP
Zhang
D019943:Amino Acid Substitution / Q000235:genetics*; D005075:Biological Evolution; D001351:Infectious bronchitis virus / Q000235:genetics*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics; D014765:Viral Vaccines / Q000138:chemical synthesis
D014765:Viral Vaccines