Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra.
Methanol and hot-aqueous extracts of 25 different plant species, used in Yemeni traditional medicine and growing, partly as endemic plants, on the island Soqotra have been investigated for their antiviral activity. In addition, the phytochemical identification of the main chemical constituents was performed. The extracts were assayed in two in vitro viral systems, which used influenza virus type A/MDCK cells and herpes simplex virus type 1/Vero cells, at non-cytotoxic concentrations. The herpes simplex virus type 1 showed more sensitivity than the influenza virus type A against the extracts investigated. The methanol extracts of Boswellia ameero, Boswellia elongata, Buxus hildebrandtii, Cissus hamaderohensis, Cleome socotrana, Dracaena cinnabari, Exacum affine, Jatropha unicostata and Kalanchoe farinacea showed anti-influenza virus type A activity with 50% inhibition (IC50) concentrations ranging from 0.7 to 12.5 microg/mL. In addition, 17 plants of the 25 investigated exhibited anti-HSV-1 activity. The antiviral activity of some active extracts was also observed on a molecular level.
Department of Pharmacognosy, Faculty of Pharmacy, Sana'a-University, P.O. Box 33039, Sana'a-Yemen.
Ramzi A A
RA
Mothana
Renate
R
Mentel
Christiane
C
Reiss
Ulrike
U
Lindequist
D000818:Animals; D000998:Antiviral Agents / Q000032:analysis* / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004285:Dogs; D006568:Herpesvirus 1, Cercopithecine / Q000187:drug effects*; D009980:Influenza A virus / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014709:Vero Cells; D015006:Yemen
D000998:Antiviral Agents; D010936:Plant Extracts