Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances.
Melanin-concentrating hormone (MCH) is a critical hypothalamic anabolic neuropeptide, with key central and peripheral actions on energy balance regulation. The actions of MCH are, so far, known to be transduced through two seven-transmembrane-like receptor paralogues, named MCH1R and MCH2R. MCH2R is not functional in rodents. MCH1R is an important receptor involved in mediating feeding behaviour modulation by MCH in rodents. Pharmacological antagonism at MCH1R in rodents diminishes food intake and results in significant and sustained weight loss in fat tissues, particularly in obese animals. Additionally, MCH1R antagonists have been shown to have anxiolytic and antidepressant properties. The purpose of this review is to highlight the recent numerous pieces of evidence showing that pharmacological blockade at MCH1R could be a potential treatment for obesity and its related metabolic syndrome, as well as for various psychiatric disorders.
GlaxoSmithKline R&D, Neurology Centre of Excellence for Drug Discovery, NFSP-North, HW1713 Building H17, L1-130 C06 Third Avenue, Harlow, Essex CM19 5AW, UK. gjhervieu@hotmail.com
Guillaume J
GJ
Hervieu
D000339:Affect / Q000502:physiology*; D000818:Animals; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007028:Hypothalamic Hormones / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D008543:Melanins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D009446:Neurobiology; D010907:Pituitary Hormones / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors / Q000378:metabolism
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; D017481:Receptors, Somatostatin; C019463:melanin-concentrating hormone