Continuous renal replacement therapy in patients following traumatic injury.
In critically injured patients, the incidence of acute renal failure has been reported to occur in as many as 31% of patients. The use of CRRT modalities for patients following traumatic injuries is becoming more common, albeit slowly, and this therapy may impact upon long-term recovery of renal function and mortality. Historical studies investigating the early use of intermittent dialysis reported significant improvement in survival in patients who were dialyzed earlier and more vigorously than in control subjects. Early trauma patients also showed improved survival following war injuries when dialyzed prophylactically. Although there is a growing acceptance in favor of earlier renal replacement therapy, the published consensus and the practice in many centers has been to dialyze/filter relatively ill rather than relatively healthy patients. The R Adams Cowley Shock Trauma Center (STC) in Baltimore, Maryland, USA, admits over 8,000 trauma patients each year. Within the STC, a program of continuous renal replacement therapy was established in the early 1980's. We review both historical and current literature on the use of renal replacement therapies after traumatic injury, and suggest some future areas of investigation and indications for these modalities.
Division of Surgical Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. mmccunn@umm.edu
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M
McCunn
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Reynolds
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Reuter
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McQuillan
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McCourt
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Stein
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics; D003422:Critical Care / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007688:Kidneys, Artificial; D018529:Nutritional Support; D015742:Propofol / Q000009:adverse effects; D017582:Renal Replacement Therapy / Q000379:methods; D012206:Rhabdomyolysis / Q000150:complications; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000150:complications / Q000628:therapy; D014947:Wounds and Injuries / Q000150:complications*
D000925:Anticoagulants; D006993:Hypnotics and Sedatives; D015742:Propofol