High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries.
We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.
Centre de Génétique Médicale, Hôpital d'Enfants, Dijon, France. laurence.faivre@chu-dijon.fr
Laurence
L
Faivre
Jörg
J
Meerpohl
Lydie
L
Da Costa
Isabelle
I
Marie
Christian
C
Nouvel
Astrid
A
Gnekow
Christine
C
Bender-Götze
Francis
F
Bauters
Bertand
B
Coiffier
Pierre-Yves
PY
Peaud
Patrick
P
Rispal
Alain
A
Berrebi
Claire
C
Berger
Michel
M
Flesch
Paul
P
Sagot
Bruno
B
Varet
Charlotte
C
Niemeyer
Gil
G
Tchernia
Thierry
T
Leblanc
D000740:Anemia / Q000517:prevention & control; D029503:Anemia, Diamond-Blackfan / Q000150:complications* / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D003625:Data Collection; D005260:Female; D005602:France; D005858:Germany; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000209:etiology; D012042:Registries; D012189:Retrospective Studies
D001241:Aspirin