[Morphological characteristics of stromal gastrointestinal tumors].
Stromal tumors are singled out from smooth muscle and neurogenic neoplasms into a special group due to differences in CD117 expression caused by mutation of c-kit gene. Out of 57 stromal tumors, 37 (64,9%) located in the stomach, 17 (29,8%) in the small intestine and 3 (5,3%) in the colon. Immunohistochemically, all the tumors expressed CD117 and vimentine. Smooth muscle actin was found in 82% tumors, S-100 protein in 75%, neuron-specific enolase in 66% cases. Malignant tumors were in 93% cases, and in 7% benign. Metastases were observed in 47.7% cases, recurrences in 14%. The liver was most frequent site of metastases (88.9%), peritoneum (51.9%). 21% patients died of progression of the underlying disease during the follow-up of 6-60 months.
O A
OA
Anurova
P V
PV
Snigur
N A
NA
Filippova
V Iu
VIu
Sel'chuk
D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000556:secondary; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000556:secondary; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
D009363:Neoplasm Proteins