CDK inhibitor targets: a hit or miss proposition?: cyclin-dependent kinase inhibitors kill tumor cells by downregulation of anti-apoptotic proteins.
Dai
Yun
Y
Division of Hematology/Oncology and Department of Medicine, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. ydai@hsc.vcu.edu
Grant
Steven
S
D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D015536:Down-Regulation; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy*; D014158:Transcription, Genetic / Q000187:drug effects*
D004791:Enzyme Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D018844:Cyclin-Dependent Kinases