Endotracheal delivery of medications during neonatal resuscitation.
If the endotracheal route is to be used for administration of epinephrine, the limited available evidence suggests that the currently recommended dose of 0.01 mg/kg is likely to be too low to be effective. Given the paucity of high-quality clinical data regarding endotracheal epinephrine, the intravenous route should be used as soon as venous access is established. Given the complete lack of clinical data in newborns, endotracheal administration of naloxone is not recommended.
Wyckoff
Myra H
MH
Department of Pediatrics, Division of Neonatal/Perinatal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75290-9063, USA. myra.wyckoff@utsouthwestern.edu
Wyllie
Jonathan
J
D000322:Adrenergic Agonists / Q000008:administration & dosage*; D000818:Animals; D001238:Asphyxia Neonatorum / Q000628:therapy; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004837:Epinephrine / Q000008:administration & dosage*; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal
D000322:Adrenergic Agonists; D004837:Epinephrine