A new dynamic index of insulin sensitivity.
Insulin sensitivity is a crucial parameter of glucose metabolism. The standard measures of insulin sensitivity obtained by an euglycaemic hyperinsulinaemic clamp, Si(clamp), or by the minimal model (MM), SI, do not account for the dynamics of insulin action, i.e., how fast or slow insulin action reaches its plateau value. This is an important physiological information. In this paper we formally define a new insulin sensitivity index which also incorporates information on the dynamics of insulin action, SD(I), show its properties, and exemplify how it can be measured both with the clamp and the MM method. Then, by resorting to real and synthetic data, we show both in IVGTT MM and clamp studies why this new index SD(I) offers, in comparison with SI, a more comprehensive picture of the control of insulin on glucose.
Pillonetto
Gianluigi
G
Department of Information Engineering, University of Padova, 35131 Padova, Italy.
Caumo
Andrea
A
Sparacino
Giovanni
G
Cobelli
Claudio
C
D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D015309:Glucose Clamp Technique / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D007328:Insulin