Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes.
In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised starting from 2-aryloyl-3-methyl-benzofuranes. The structure elucidation of the compounds was performed by IR, 1H-NMR, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. ngundogd@anadolu.edu.tr
Nalan
N
Gündoğdu-Karaburun
Kadriye
K
Benkli
Yağmur
Y
Tunali
Umit
U
Uçucu
Seref
S
Demirayak
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001393:Azoles; D001572:Benzofurans; D007093:Imidazoles; D010091:Oximes; C029899:imidazole; C105430:benzofuran