Complete hydatidiform mole and normal live birth following intracytoplasmic sperm injection.
A twin pregnancy with complete hydatidiform mole (HM) and preterm birth of a normal female infant after intracytoplasmic sperm injection (ICSI) conception was experienced. ICSI due to severe oligozoospermia was performed on three ova, and three embryos with confirmed two proneclei (2PN) were subsequently transferred to the uterus. At 7 weeks of gestation, molar pregnancy as well as a viable fetus was recognized. At 33 weeks, the pregnancy was terminated due to preterm labor. Dichorionic pregnancy consisting of a normal fetus and placenta in one chorionic membrane and complete HM in the other was recognized. Cytomolecular analysis indicated that the complete HM genome was derived from duplication of a single sperm, and a normal neonate was from biparental genomes. It should be noted that ICSI can avoid incomplete HM (mostly triploid) due to multi-sperm fertilization but might not be able to avoid complete HM (paternal diploid) although such a risk is very low. This is the second report of this condition and is accompanied by the first well-described molecular analysis.
Hamanoue
Haruka
H
Department of Human Genetics, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.|Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Umezu
Nobuko
N
Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Okuda
Mika
M
Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Harada
Naoki
N
Kyushu medical Science Nagasaki Laboratory, Nagasaki, Japan.|Solution-Oriented Research for Science and Technology (SORST), JST, Kawaguchi, Japan.
Ohata
Takako
T
Department of Human Genetics, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Sakai
Haruya
H
Department of Human Genetics, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Mizuguchi
Takeshi
T
Department of Human Genetics, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.|Solution-Oriented Research for Science and Technology (SORST), JST, Kawaguchi, Japan.
Ishikawa
Hiroshi
H
Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Takahashi
Tsuneo
T
Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Miura
Kiyonori
K
Departments of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hirahara
Fumiki
F
Department of Obstetrics and Gynecology and Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Matsumoto
Naomichi
N
Department of Human Genetics, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. naomat@yokohama-cu.ac.jp.|Solution-Oriented Research for Science and Technology (SORST), JST, Kawaguchi, Japan. naomat@yokohama-cu.ac.jp.
D000328:Adult; D005260:Female; D005333:Fetus / Q000648:ultrastructure; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics*; D050498:Live Birth; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D016216:Ultrasonography, Prenatal; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics*