A case of sclerodermatous graft-versus-host disease following autologous peripheral blood stem cell transplantation.
We report a 65-year-old woman with chronic graft-versus-host disease (GVHD) who developed severely sclerotic skin on the fingers, hand and trunk following autologous peripheral blood stem cell transplantation (APBSCT). The patient had suffered from breast cancer and been treated with surgery and chemotherapy. She showed pancytopenia and was treated with APBCST. Four years after APBSCT, she developed the severe sclerotic changes on the fingers, hands, extremities and trunk. The skin biopsy showed a flattened epidermis and a proliferation of collagen bundles in the dermis. No anti-nucleolar DNA titers were detected in the serum. She was diagnosed with chronic GVHD. Despite treatment with oral prednisolone, the skin sclerotic change developed and the breast cancer recurred. She died due to pericarditis. This is a rare case of sclerodermatous GVHD following APBSCT. The serum interleukin (IL)-12 levels were examined during the treatment.
Nakamura
Koichiro
K
Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan. nakamu-k@fmu.ac.jp
Kawakami
Yoshio
Y
Oyama
Noritaka
N
Kaneko
Fumio
F
Abe
Hiroyuki
H
Sagara
Hiroya
H
Ohto
Hitoshi
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010198:Pancytopenia / Q000139:chemically induced / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D018570:Risk Assessment; D012594:Scleroderma, Localized / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D014182:Transplantation, Autologous / Q000009:adverse effects
D007166:Immunosuppressive Agents