Fine needle aspiration biopsy of gastrointestinal stromal tumor presenting as an umbilical mass (Sister Mary Joseph's Nodule).
The Sister Mary Joseph (SMJ) nodule is a clinical sign of metastatic cancer involving the umbilicus. The vast majority of these instances represent adenocarcinomas arising from ovarian or colorectal primaries. We present a patient who presented with ascites and the SMJ lesion that turned out to be a metastatic gastrointestinal stromal tumor after fine needle aspiration biopsy was performed. The lesion was subsequently histologically confirmed. Gastrointestinal stroma tumor involving the umbilicus is exceedingly uncommon and only rarely presents in this fashion. The cytomorphological features, differential diagnosis, and comparison with the tissue specimen are made.
Scudeler
Donizete
D
Department of Pathology, São Paulo State University, Botucatu 01318-901, Brazil.
Wakely
Paul E
PE
D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary*; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D014472:Umbilicus / Q000473:pathology