Pleomorphic adenoma of the salivary gland in two dogs.
Pleomorphic adenomas of the salivary gland were diagnosed in two dogs. The tumours were single, firm and well circumscribed, with a smooth cut surface. Metastatic tumours were not detected. Histopathological examination revealed that the tumours contained multiple cysts lined with luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues. Immunohistochemical examination demonstrated labelling of luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues with antibodies to cytokeratin LU-5, AE1/AE3, CK-14, CALP, a-SMA, vimentin, GFAP, and S-100. Labelling for GFAP indicated stromal transformation into myxoid and chondroid tissues.
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Y
Y
Shimoyama
K
K
Yamashita
T
T
Ohmachi
Y
Y
Akihara
T
T
Sako
K
K
Hirayama
M
M
Okamoto
H
H
Taniyama
D008949:Adenoma, Pleomorphic / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008297:Male; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012469:Salivary Glands / Q000473:pathology / Q000601:surgery; D013362:Sublingual Gland Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
D014408:Biomarkers, Tumor