Osteonecrosis in patients with acquired immunodeficiency syndrome (AIDS): report of two cases and review of the literature.
An increase in the incidence of abnormalities on bone and mineral metabolism (osteopenia/osteoporosis) and the development of osteonecrosis has been observed in patients with acquired immunodeficiency syndrome (AIDS). Two cases of osteonecrosis in patients with AIDS are reported. Both patients were receiving highly active antiretroviral therapy (HAART) and presented with one or more known risk factors for osteonecrosis. We review the literature and discuss the pathogenesis, diagnosis, prevention and treatment of this entity in patients with AIDS.
Departamento de Medicina Interna, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ. gibalarini@alternex.com.br
Giovanna A Balarini
GA
Lima
Juan Carlos Rosso
JC
Verdeal
Maria Lucia F de
ML
Farias
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D012307:Risk Factors