Implantation of human demineralized bone matrix (DBM) for the treatment of juvenile bone cysts.
OBJECTIVE
Definitive bony consolidation in juvenile bone cysts. Prevention of pathologic fractures. Preservation of limb function.


METHODS
Juvenile bone cysts at all sites.


METHODS
Malignant cystic lesions.


METHODS
After opening and curettage, the cyst is packed with human demineralized bone matrix (DBM).


METHODS
Clinical and radiologic checks after 1, 4, and 6 months, followed by further 6-monthly checks.


RESULTS
Over a period of 2 years, nine cysts packed with DBM showed almost totally osteodense images after an average of 8 months, with no other significant changes (follow-up period: 24 months). A typical decrease in cyst transparency on the plain radiographs was already detectable in all patients after 3-4 months. Marked cortical remodeling was visible after 6 months. A significant complication in one cyst in the distal tibial region was a pathologic fracture following distortion trauma; this occurred after 5 months, probably because of insufficient filling of the cyst. The fractured limb was immobilized in a lower-leg cast and healed sufficiently for stable weight bearing after 12 weeks.
Klinik für Kinderchirurgie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg. hans-juergen.hass@medizin.uni-magdeburg.de
Hans-Jürgen
HJ
Hass
Hardy
H
Krause
Steffen
S
Kroker
Winfried
W
Wagemann
D000293:Adolescent; D000367:Age Factors; D001845:Bone Cysts / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D001857:Bone Matrix / Q000637:transplantation*; D019485:Bone Morphogenetic Proteins; D016723:Bone Remodeling; D002370:Casts, Surgical; D002648:Child; D002675:Child, Preschool; D003475:Curettage; D005260:Female; D005500:Follow-Up Studies; D017102:Fracture Healing; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007103:Immobilization; D008297:Male; D011182:Postoperative Care; D011859:Radiography; D012737:Sex Factors; D013978:Tibial Fractures / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
D019485:Bone Morphogenetic Proteins