Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium.
OBJECTIVE
Mycoplasma genitalium has been associated with male urethritis. We sought to relate M. genitalium to genitourinary signs and symptoms in women.


METHODS
We compared 26 culture-positive women (group 1), 257 additional polymerase chain reaction-positive women (group 2), and 107 negative control women. We used logistic regression to evaluate signs and symptoms, controlling for co-infections, pregnancy, age, and intervention group assignment.


RESULTS
Comparing group 1 with controls, we found significantly elevated odds ratios (ORs) for intermediate vaginal discharge (OR = 5.4; 95% confidence interval 1.01, 29.2) and action in response to discharge [3.9 (1.1, 13.5)]. Non-significant increases were observed for pathologic vaginal discharge [3.8 (0.78, 18.2)], pathologic dyspareunia [1.5 (0.25, 9.0)], vaginal odor [2.1 (0.75, 5.7)], and cervical mucopus [4.1 (0.74, 22.4)]. Group 2 results were similar, but showed no increase in cervical mucopus relative to controls.


CONCLUSIONS
Infection with M. genitalium in women is independently related to increased genitourinary symptomatology.
Department of Obstetrics and Gynecology, School of Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. kortej@uthscsa.edu
Jeffrey E
JE
Korte
Joel B
JB
Baseman
Marianna P
MP
Cagle
Caleb
C
Herrera
Jeanna M
JM
Piper
Alan E C
AE
Holden
Sondra T
ST
Perdue
Jane D
JD
Champion
Rochelle N
RN
Shain
D000293:Adolescent; D000328:Adult; D046508:Culture Techniques; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology*; D045704:Mycoplasma genitalium / Q000254:growth & development* / Q000302:isolation & purification*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D015231:Sexually Transmitted Diseases, Bacterial / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology; D002575:Uterine Cervicitis / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology*