Duration of immunity engendered by a single dose of a cold-adapted strain of Avian pneumovirus.
The duration of immunity after a single dose of a cold-adapted strain of Avian pneumovirus (APV) was studied. Turkeys were vaccinated at 1 wk of age and challenged with virulent virus 3, 7, 10, and 14 wk later. Nonvaccinated groups were also challenged at the same times. No clinical signs were observed in the vaccinated birds after vaccination or after any challenge. No viral RNA was shed by the vaccinated birds after any challenge. The nonvaccinated birds shed viral RNA after all challenges. Avian pneumovirus-specific humoral antibodies were detected in the vaccinated birds until 14 wk after vaccination. The results of this preliminary study indicate that inoculation with a single dose of a cold-adapted strain of APV at 1 wk of age provides protection until 15 wk of age.
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Avenue, St. Paul, Minnesota 55108, USA.
Devi P
DP
Patnayak
Sagar M
SM
Goyal
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D003080:Cold Temperature; D029121:Metapneumovirus / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000517:prevention & control* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D011897:Random Allocation; D014422:Turkeys; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence; D017201:Virus Shedding
D000914:Antibodies, Viral; D012367:RNA, Viral; D014765:Viral Vaccines