Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration.
In order to understand the requirements of guided bone regeneration (GBR) involving alginate base self-setting barrier membranes, GBR was performed in the case of bicortical bone defects formed at the tibiae of experimental animals employing self-setting and ready-made alginate membranes. Connective tissue ingress into the bone defects at the skin side of the tibia was observed when GBR was generated utilizing ready-made alginate membrane. In contrast, bone defects were reconstructed with bone tissue when GBR was generated with self-setting alginate membrane formed from aqueous 3% sodium alginate and 3% CaCl(2) solutions. The unreacted aqueous sodium alginate solution inherent to self-setting alginate membrane did not inhibit bone tissue regeneration. Rather, callus bone was formed using sodium alginate as the nucleus. However, when GBR was effected with self-setting alginate membrane formed from aqueous 10% CaCl(2) solution, membrane was too thick and thus regeneration of bone tissue in the bone cavity was prevented. Therefore, we concluded that self-setting alginate membrane is very useful as a barrier membrane for GBR upon appropriate adjustment of conditions with respect to preparation of alginate membrane.
Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine, Ube, Japan. uyoshiya@yamaguchi-u.ac.jp
Yoshiya
Y
Ueyama
Takahiro
T
Koyama
Kunio
K
Ishikawa
Takamitsu
T
Mano
Yukio
Y
Ogawa
Hitoshi
H
Nagatsuka
Kazuomi
K
Suzuki
D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D002122:Calcium Chloride / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D066298:In Vitro Techniques; D008297:Male; D008567:Membranes, Artificial; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D013977:Tibia / Q000502:physiology*
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D020723:Glucuronic Acid; D002122:Calcium Chloride