An effective structure learning method for constructing gene networks.
BACKGROUND
Bayesian network methods have shown promise in gene regulatory network reconstruction because of their capability of capturing causal relationships between genes and handling data with noises found in biological experiments. The problem of learning network structures, however, is NP hard. Consequently, heuristic methods such as hill climbing are used for structure learning. For networks of a moderate size, hill climbing methods are not computationally efficient. Furthermore, relatively low accuracy of the learned structures may be observed. The purpose of this article is to present a novel structure learning method for gene network discovery.


RESULTS
In this paper, we present a novel structure learning method to reconstruct the underlying gene networks from the observational gene expression data. Unlike hill climbing approaches, the proposed method first constructs an undirected network based on mutual information between two nodes and then splits the structure into substructures. The directional orientations for the edges that connect two nodes are then obtained by optimizing a scoring function for each substructure. Our method is evaluated using two benchmark network datasets with known structures. The results show that the proposed method can identify networks that are close to the optimal structures. It outperforms hill climbing methods in terms of both computation time and predicted structure accuracy. We also apply the method to gene expression data measured during the yeast cycle and show the effectiveness of the proposed method for network reconstruction.
Chen
Xue-Wen
XW
Bioinformatics and Computational Life Sciences Laboratory, Electrical Engineering and Computer Science Department, 1520 West 15th Street, The University of Kansas, Lawrence, KS 66045, USA. xwchen@ku.edu
Anantha
Gopalakrishna
G
Wang
Xinkun
X
D000465:Algorithms; D001185:Artificial Intelligence; D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods*; D005656:Fungal Proteins; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D016571:Neural Networks, Computer; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software
D005656:Fungal Proteins