Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88.
Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.
Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-7286, USA.
Illona
I
Gillette-Ferguson
Amy G
AG
Hise
Yan
Y
Sun
Eugenia
E
Diaconu
Helen F
HF
McGarry
Mark J
MJ
Taylor
Eric
E
Pearlman
D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D015818:Eye Infections, Bacterial / Q000235:genetics / Q000276:immunology*; D007634:Keratitis / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D053594:Myeloid Differentiation Factor 88; D009504:Neutrophils / Q000276:immunology; D017181:Onchocerca volvulus / Q000276:immunology*; D015827:Onchocerciasis, Ocular / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000502:physiology; D020577:Wolbachia / Q000276:immunology* / Q000472:pathogenicity
D048868:Adaptor Proteins, Signal Transducing; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D051193:Toll-Like Receptors