Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder.
OBJECTIVE
The effect of lamotrigine maintenance therapy on body weight was assessed retrospectively in analyses of data from two double-blind, placebo- and lithium-controlled, 18-month studies in patients with bipolar I disorder (n = 227 for lamotrigine, 190 for placebo, 166 for lithium).


METHODS
Endpoints included mean change in weight, the percentage of patients with > or = 7% change (increase, decrease, fluctuation) in weight, and the percentage of patients with weight-related adverse events during double-blind treatment.


RESULTS
Mean weight remained stable during maintenance therapy with lamotrigine. In a mixed-model repeated-measures analysis, mean changes in weight (kg) at week 52 were -1.2 with lamotrigine, +0.2 with placebo, and +2.2 with lithium [estimated difference (95% CI) lamotrigine minus placebo = -1.3 (-3.6, 0.9), p = 0.237; lithium minus placebo = +2.0 (-0.3, 4.4), p = 0.094; lithium minus lamotrigine = +3.4 (1.4, 5.4), p < 0.001]. Analyses were truncated at week 52 because of the high incidence of missing data at later time points. The percentages of patients with a >/=7% weight gain, during randomized treatment, were 10.9%, 7.6% and 11.8% for the lamotrigine, placebo, and lithium groups, respectively. The percentages of patients with a > or = 7% weight loss, during randomized treatment, were 12.1%, 11.5%, and 5.1% for the lamotrigine, placebo, and lithium groups, respectively. The percentage of patients with a > or = 7% weight loss did not significantly differ between lamotrigine and placebo but was significantly higher with lamotrigine than lithium. The incidences of > or = 7% weight changes and of weight changes reported as adverse events were comparable between active treatments and placebo.


CONCLUSIONS
Lamotrigine was associated with stable body weight during 1 year of treatment and was comparable to placebo in mean weight change, incidence of clinically significant weight change, and incidence of weight changes reported as adverse events in patients with bipolar disorder. Lithium was associated with weight gain, but the magnitude of lithium-associated weight gain was lower in the current analysis than in previous studies.
Department of Psychiatry, Harvard University, Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA. sachsg@aol.com
Gary
G
Sachs
Charles
C
Bowden
Joseph R
JR
Calabrese
Terence
T
Ketter
Thomas
T
Thompson
Robin
R
White
Beth
B
Bentley
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D000077213:Lamotrigine; D016651:Lithium Carbonate / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control; D015995:Prevalence; D012189:Retrospective Studies; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D014227:Triazines; D016651:Lithium Carbonate; D000077213:Lamotrigine