The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts.
OBJECTIVE
The aim of this study was to examine the ability of platelet-enriched fibrin glue to enhance bone formation in critically sized defects in the dog mandible.


METHODS
Seven adult female mongrel dogs underwent continuity resections on both sides of the mandible; 1 defect was reconstructed with the original particulate bone mixed with platelet-enriched fibrin glue, and as a control the contralateral defect was reconstructed with the original particulate bone alone.


RESULTS
Biopsies after 6 weeks showed that the addition of platelet-enriched fibrin glue enhanced new bone formation in the autogenous bone grafts.


CONCLUSIONS
Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in platelet-enriched fibrin glue, might effectively promote bone healing at bone graft sites.
Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
Jin-Young
JY
Huh
Byung-Ho
BH
Choi
Shi-Jiang
SJ
Zhu
Jae-Hyung
JH
Jung
Byung-Yong
BY
Kim
Seoung-Ho
SH
Lee
D000818:Animals; D001792:Blood Platelets; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods*; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D008334:Mandible / Q000601:surgery; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D018709:Statistics, Nonparametric
D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D010982:Platelet-Derived Growth Factor