Effect of using an echogenic catheter for ultrasound-guided embryo transfer in an IVF programme: a prospective, randomized, controlled study.
BACKGROUND
Recent evidence showed that ultrasound-guided embryo transfer significantly increases successful implantation compared to the clinical touch method. It has been postulated that new echodense catheters which are more readily detectable by ultrasound may refine transfer techniques even more, thus improving IVF outcome.


METHODS
A prospective, randomized, controlled trial comparing IVF outcome for women undergoing embryo transfer under ultrasound guidance by a single healthcare provider with random assignment according to a computer-generated randomization table to either standard soft Wallace catheter (standard catheter group, n=95) or the new echogenic soft Wallace catheter (echogenic catheter group, n=98).


RESULTS
The use of the echodense catheter facilitated catheter identification under ultrasound, and thus the duration of the embryo transfer procedure since the loaded catheter was handed to the physician and up to embryo discharge was significantly shorter in the echogenic catheter group as compared with the standard catheter group. There were 39 and 53 clinical pregnancies in the standard catheter (41%) and echogenic catheter (54.1%) groups, respectively. This was not statistically significant (P=0.08) according to the OR (0.6) and CIs (0.33-1.04). However, twin pregnancy rate was significantly increased (P<0.01) with the use of the new catheter which was the underlying source for obtaining significant increase in implantation rate in this group (37.1%) as compared with the standard catheter group (23.2%).


CONCLUSIONS
This pilot study suggests that the use of the echogenic Wallace catheter simplifies ultrasound-guided embryo transfer but not definite benefit in terms of pregnancy rates was obtained. In contrast, the use of the new catheter was associated with a significant increase in the number of twin pregnancies.
Department of Obstetrics and Gynaecology, Service of Reproductive Medicine, Institut Universitari Dexeus, and Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. vencour@dexeus.com
Buenaventura
B
Coroleu
Pedro N
PN
Barri
Olga
O
Carreras
Itziar
I
Belil
Rosario
R
Buxaderas
Anna
A
Veiga
Juan
J
Balasch
D000328:Adult; D004624:Embryo Transfer / Q000295:instrumentation*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple; D014427:Twins; D014463:Ultrasonography / Q000295:instrumentation