Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature.
OBJECTIVE
The purpose of this article is to briefly review the literature of corticosteroid-induced ocular hypertension and glaucoma, its risk factors, the pathophysiology, and treatment options. In particular, literature pertaining to glaucoma in response to intravitreal triamcinolone acetonide will be reviewed.


RESULTS
Primary open-angle glaucoma, status as a glaucoma suspect, and a family history of glaucoma are risk factors for an ocular hypertensive response with the use of corticosteroid therapy. Recent studies suggest that younger age may also be a risk factor in patients treated via the intravitreal route with corticosteroids. The mechanism of elevated intraocular pressure is increased aqueous outflow resistance owing to an accumulation of extracellular matrix material in the trabecular meshwork.


CONCLUSIONS
Corticosteroid-induced ocular hypertension and glaucoma has been recognized for more than 50 years. Knowing the risk factors, prevalence, and pathophysiology can help the clinician prevent, monitor, and treat corticosteroid-induced ocular hypertension and glaucoma.
Harvard Medical School, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Glaucoma Service, Boston, Massachusetts 02114, USA.
Relief
R
Jones
Douglas J
DJ
Rhee
D015862:Choroid Diseases / Q000188:drug therapy; D005902:Glaucoma, Open-Angle / Q000139:chemically induced* / Q000503:physiopathology; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D009798:Ocular Hypertension / Q000139:chemically induced / Q000503:physiopathology; D012164:Retinal Diseases / Q000188:drug therapy; D012307:Risk Factors; D014222:Triamcinolone Acetonide / Q000009:adverse effects*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide