Serum adiponectin levels increase after human chorionic gonadotropin treatment during in vitro fertilization.
OBJECTIVE
To determine whether or not serum adiponectin concentrations are influenced by ovarian hyperstimulation during in vitro fertilization (IVF).


METHODS
This study involved 52 women who were participating in IVF-ET cycles. Adiponectin levels in serum were determined by radioimmunoassay and compared.


RESULTS
Serum adiponectin levels fell from Day-basal to Day-hCG (p = 0.047), and then rose on Day-OR and again on Day-7ET (p < 0.001; p < 0.001). Estradiol levels on Day-hCG were significantly and positively correlated with serum adiponectin levels on Day-OR and Day-7ET (r = 0.325, p = 0.019; r = 0.372, p = 0.007). Progesterone levels on Day-OR positively correlated with serum adiponectin levels on Day-basal (r = 0.278, p = 0.046). There was also a positive correlation between progesterone levels on Day-7ET and serum adiponectin levels on Day-OR (r = 0.289, p = 0.038). Multiple linear regression analysis revealed that adiponectin levels on Day-OR and Day-7ET were negatively correlated with age and body mass index after adjustment was made for concomitant diseases.


CONCLUSIONS
To sum up, following gonadotropin treatment, serum adiponectin levels decrease as a result of the negative effect of high estradiol levels on adiponectin production. Conversely, serum adiponectin levels increase following human chorionic gonadotropin treatment.
Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Yung-Hsien
YH
Liu
Eing-Mei
EM
Tsai
Yi-Ling
YL
Chen
Hung-Sheng
HS
Chen
Yu-Chieh
YC
Chen
Lee-Chen
LC
Wu
Chien-Hung
CH
Lee
Shiang-Bin
SB
Jong
Te-Fu
TF
Chan
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects / Q000379:methods; D006801:Humans; D016014:Linear Models; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D011374:Progesterone / Q000097:blood*; D013997:Time Factors
D052242:Adiponectin; D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol