Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases.
Sporadic cases of hepatocellular carcinoma (HCC) originating from nonalcoholic steatohepatitis (NASH) have recently been reported. Thus, we investigated the prevalence of NASH in patients with HCC. A review of the clinical records of 481 patients who underwent liver resection for HCC in our department between January 1991 and December 2003 revealed only two (0.4%) patients with HCC associated with NASH. Both of these patients had noninsulin-dependent diabetes mellitus, and neither had a history of alcohol consumption or blood transfusion. All serologic markers for hepatitis B and C viruses were negative. Histological examination of the noncancerous hepatic tissue revealed NASH with moderate hepatic fibrosis in one patient and cirrhosis in the other. Thus, clinical follow-up and screening for HCC should be done for patients with hepatic fibrosis caused by NASH, even though this form of hepatitis is an uncommon cause of HCC.
Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Japan.
Seikan
S
Hai
Shoji
S
Kubo
Taichi
T
Shuto
Hiromu
H
Tanaka
Shigekazu
S
Takemura
Takatsugu
T
Yamamoto
Akishige
A
Kanazawa
Masao
M
Ogawa
Kazuhiro
K
Hirohashi
Kenichi
K
Wakasa
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D018570:Risk Assessment; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis; D014057:Tomography, X-Ray Computed