Glucose management during and after intensive delivery room resuscitation.
Hypoxic-ischemic encephalopathy remains a major cause of morbidity and mortality in preterm and full-term infants. Experimental data from animal studies suggest that interventions that improve survival of injured neurons and prevent delayed neuronal loss may decrease hypoxic ischemic brain injury. Considerable attention has focused on optimizing management of newborns in the period immediately after resuscitation from perinatal asphyxia to minimize delayed neuronal death. The evidence regarding the role of glucose in modifying post-asphyxia brain injury and resuscitation was reviewed to better define optimal glucose management after perinatal asphyxia and resuscitation.
Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. jmcgowan@jhmi.edu
Jane E
JE
McGowan
Jeffrey M
JM
Perlman
D000818:Animals; D001238:Asphyxia Neonatorum / Q000150:complications / Q000628:therapy*; D003696:Delivery Rooms; D005947:Glucose / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007003:Hypoglycemia / Q000150:complications* / Q000188:drug therapy; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology* / Q000517:prevention & control; D007231:Infant, Newborn; D012151:Resuscitation; D013549:Sweetening Agents / Q000494:pharmacology / Q000627:therapeutic use
D013549:Sweetening Agents; D005947:Glucose