Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer.
After total thyroidectomy, differentiated thyroid cancer (DTC) patients have to undergo L-T4 withdrawal for measuring serum thyroglobulin and 131I whole-body scan (131I WBS) to evaluate residual/recurrent malignant disease. The aim of the present work was to study in these patients the effects of acute thyroid hormone deficiency on various target organs and tissues. Clinical parameters and thyroid function peripheral markers were evaluated in 20 DTC patients, both before and after L-T4 withdrawal. A 24-h urine collection, a fasting blood sample for laboratory examinations, a clinical score for hypothyroidism and cardiovascular, neurological and neuropsychological evaluations were carried out. After L-T4 withdrawal, the clinical score significantly increased, as well as total cholesterol, triglycerides, creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase, whereas SHBG, osteocalcin and urine hydroxyproline levels significantly decreased. The acute thyroid hormone deficiency caused a systolic dysfunction of the left ventricle associated with an increase in systemic vascular resistance without cardiac contractility alterations. A significant increase in the left ventricular mass and thickness was also observed. Carpal tunnel syndrome appeared in 30% of patients and a significant reduction in the immediate auditive memorization and in attentive performance was also detected. These observations indicate that acute hypothyroidism causes significant clinical alterations of peripheral tissue function. In the follow-up of DTC patients, therefore, L-T4 withdrawal procedure should be restricted to cases where the cost/benefit ratio is favorable. Alternative procedures, such as the use of recombinant human TSH, should be used whenever possible.
Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Italy. segmeint@unict.it
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Regalbuto
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Alagona
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Maiorana
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Di Paola
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Cianci
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Alagona
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Sapienza
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Vigneri
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Pezzino
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D008875:Middle Aged; D009483:Neuropsychological Tests; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology*; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D013974:Thyroxine / Q000009:adverse effects* / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013954:Thyroglobulin; D013974:Thyroxine