[Clinical application of human tissue engineered skin with full thickness on donor site of split thickness skin graft in burn wounds].
OBJECTIVE
To observe the clinical effect of the human tissue engineered active skin (ActivSkin) with full thickness on the donor site of the split thickness skin graft.


METHODS
Nine patients with 18 wounds of the donor sites, and every patient had 2 wounds. The wounds of each patient were randomly assigned to the therapy group and the control group. Auto-control observation was performed. Nine donor sites of the split thickness skin graft were repaired with ActivSkin in the therapy group. Nine donor sites of the split thickness skin graft were repaired with the vash oil gauze in the control group. The wound pain, the time to complete closure, and the ratio of the complete healing in the ActivSkin therapy group was measured and compared with those in the control group. The donor sites of the split thickness skin graft were assessed at 180 days of the follow-up visit.


RESULTS
The wound pain was obviously reduced after the harvesting of the skin grafts in the therapy group. The time to complete closure on the donor sites of the split thickness skin graft was significantly shorter in the ActivSkin therapy group than in the control group (9.67 +/- 2.92 d vs. 16. 56 +/- 2.96 d, P < 0.05). Both the ratios of the complete healing in the ActivSkin therapy group and the control group were 100% (P > 0.05). The subsequent results showed that neither the blister nor the residual wound occurred with an alleviated scar after the ActivSkin treatment.


CONCLUSIONS
ActivSkin can promote wound closure, prevent blister and residual wound, and alleviate scarring on the donor sites of the split thickness skin graft after the ActivSkin treatment.
Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xian Shaanxi 710032, P R China.
Yaling
Y
Liu
Yan
Y
Jin
Dahai
D
Hu
Mingda
M
Xu
Maolong
M
Dong
Yongjie
Y
Zhang
Hou'an
H
Xiao
D000293:Adolescent; D000328:Adult; D002056:Burns / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016038:Skin Transplantation; D017768:Skin, Artificial; D023822:Tissue Engineering; D014184:Transplantation, Homologous; D014945:Wound Healing