The efficacy of postoperative antibiotic regimens in the open treatment of mandibular fractures: a prospective randomized trial.
OBJECTIVE
The purpose of this study was to determine the necessity and/or effectiveness of postoperative antibiotics in the treatment of mandible fractures.


METHODS
This study is a prospective, randomized trial composed of patients who presented for operative treatment of open mandibular fractures and subsequently underwent open reduction and internal fixation at 1 institution. Mandibular fractures treated by an intraoral and/or extraoral open reduction with internal fixation were included in this study. The patients were randomly divided into 2 groups based on whether or not they received postoperative antibiotics. Both groups received preoperative antibiotics of various regimens as well as intraoperative antibiotics on the day of surgery. Group Ab patients received 2.4 mIU of intramuscular penicillin G benzathine, or if allergic, a 5- to 7-day regimen of oral clindamycin. Group non-Ab patients received no antibiotics postoperatively. Patients followed between 5 and 8 weeks were included in the data set.


RESULTS
A total of 291 patients were enrolled in the study, of which 181 patients met the inclusion criteria. Group Ab included 81 and group non-Ab 100 patients. Twenty-two patients had evidence of infection noted within the 8-week follow-up period. There were 8 infections in group Ab and 14 infections in group non-Ab. Statistical analysis with the Pearson Chi-square and Student's t test showed no statistically significant difference (P = .399) between groups Ab and non-Ab.


CONCLUSIONS
This study could not prove any statistically significant benefit to the administration of postoperative antibiotics in patients undergoing open reduction and internal fixation of mandibular fractures.
Division of Oral and Maxillofacial Surgery, Parkland Memorial Hospital, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brett A
BA
Miles
Jason K
JK
Potter
Edward
E
Ellis
D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D006801:Humans; D007273:Injections, Intramuscular; D019248:Jaw Fixation Techniques; D008297:Male; D008337:Mandibular Fractures / Q000601:surgery*; D010401:Penicillin G Benzathine / Q000008:administration & dosage; D011182:Postoperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D010401:Penicillin G Benzathine