MR spectroscopy of metabolic disorders.
The application of MR spectroscopy (MRS) in pediatric brain disorders yields valued information on pathologic processes, such as ischemia, demyelination, gliosis, and neurodegeneration. Because these processes manifest in inborn errors of metabolism, the purposes of this article are to (1) describe the spectral changes that are associated with the relatively common metabolic disorders, with summaries of known spectroscopic features of these disorders; (2) offer suggestions for recognition and distinction of disorders; and (3) provide general guidelines for MRS implementation. Although many conditions have a similar presentation, MRS offers valuable information for the individual patient in diagnosis and therapy when integrated fully into the clinical setting.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. kim.cecil@cchmc.org
Kim M
KM
Cecil
D000592:Amino Acid Metabolism, Inborn Errors / Q000175:diagnosis* / Q000378:metabolism; D001928:Brain Diseases, Metabolic / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D020271:Heredodegenerative Disorders, Nervous System / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000378:metabolism