[Factors affecting the increase of urinary diacetylspermine levels : a study in patients with liver diseases].
Recently, diacetylspermine was identified in urine and several groups have reported its clinical significance as a tumor marker. However, abnormally high values of urinary diacetylspermine are found in not a few cases with benign diseases. In order to seek which factors influence its urinary levels, we analyzed the levels in patients with various liver diseases. Our results indicate that viral amount, steroid hormones, and low calorie diet may be responsible factors to increase the levels. When we interpret the data of urinary diacetylspermine in patients, it is needed to consider whether these factors exist in the patients.
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582.
Munechika
M
Enjoji
Kazuhiro
K
Kotoh
Makoto
M
Nakamuta
D014408:Biomarkers, Tumor / Q000652:urine*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005234:Fatty Liver / Q000652:urine; D005938:Glucocorticoids / Q000009:adverse effects; D019693:Hepatitis, Autoimmune / Q000652:urine; D006525:Hepatitis, Viral, Human / Q000652:urine; D006801:Humans; D008107:Liver Diseases / Q000652:urine*; D009369:Neoplasms / Q000175:diagnosis*; D013096:Spermine / Q000031:analogs & derivatives* / Q000652:urine
D014408:Biomarkers, Tumor; D005938:Glucocorticoids; D013096:Spermine; C029453:N',N''-diacetylspermine