[Forensic chemistry: analytical developments and pharmacological aspects].
Analytical development within the field of forensic chemistry has been dominated by the increasing application of mass spectrometry techniques combined with gas or liquid chromatography, all of which improve analytical specificity and sensitivity. The impact of accreditation of standardized method validation is another important aspect. Pharmacokinetic interactions and genetic variation of the cytochrome P450 system are considered in relation to the risk of intoxication with psychoactive drugs. The role of P-glycoprotein in the distribution of drugs over the blood-brain barrier is highlighted. In conclusion, epidemiological trends in drug addiction are touched upon, and newer approaches, such as testing of hair, are considered.
Linnet
Kristian
K
Københavns Universitet, Retskemisk Afdeling, Retsmedicinsk Institut, Frederik V's Vej 11, DK-2100 København Ø. linnet@post7.tele.dk
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D001812:Blood-Brain Barrier; D002623:Chemistry Techniques, Analytical / Q000379:methods / Q000592:standards / Q000639:trends; D005554:Forensic Medicine / Q000379:methods / Q000592:standards / Q000639:trends; D006801:Humans; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D011041:Poisoning / Q000378:metabolism; D011619:Psychotropic Drugs / Q000378:metabolism / Q000506:poisoning; D012680:Sensitivity and Specificity; D019966:Substance-Related Disorders / Q000378:metabolism; D014116:Toxicology / Q000379:methods / Q000592:standards / Q000639:trends
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D011619:Psychotropic Drugs