Shedding B cell identity.
In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state.
Singh
Harinder
H
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, CIS W522, Chicago, Illinois 60637, USA.
Sciammas
Roger
R
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D051379:Mice; D051757:PAX5 Transcription Factor / Q000502:physiology*; D010950:Plasma Cells / Q000166:cytology* / Q000378:metabolism
D051757:PAX5 Transcription Factor