Pathological diagnosis of paediatric tumours from image-guided needle core biopsies: a systematic review.
BACKGROUND
Image-guided core needle biopsy is widely used in paediatric oncology, but many protocols continue to discourage this practice. No published randomized studies compare image-guided needle biopsy with surgical techniques.


OBJECTIVE
To perform a systematic review of the literature on image-guided core needle biopsy in paediatric oncology.


METHODS
Several computerized databases were searched using the terms [(needle OR core) AND (biops*[ti]) AND (paediatric OR pediatric OR child OR children OR childhood OR boy OR girl)[ti]] to identify series of more than five cases of needle core biopsy for tumour diagnosis in children. Data from included studies were combined to calculate pooled estimates of adequacy, accuracy and complication rates.


RESULTS
Thirteen studies fulfilled the inclusion criteria. Overall biopsy adequacy rate (defined as sufficient to make a diagnosis) was 94% (95% CI 92-96%). The diagnostic accuracy rate in cases with adequate material (defined as achieving the correct specific diagnosis) was 94% (95% CI 92-96%). Complications requiring treatment occurred in 1%.


CONCLUSIONS
Available pooled data suggest that about 95% of image-guided needle core biopsies provide an adequate sample for diagnosis of malignant disease in childhood. In such cases, the pathological diagnosis is correct in about 95%. Complications are rare.
Department of Paediatric Histopathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK. sebirn@gosh.nhs.uk
Neil J
NJ
Sebire
Derek J
DJ
Roebuck
D001707:Biopsy, Needle / Q000379:methods*; D002648:Child; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D010372:Pediatrics / Q000379:methods; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography