Isolation and characterization of class II myosin genes from Haemonchus contortus.
In this study, cDNAs encoding myosin from the parasitic nematode Haemonchus contortus were isolated and characterized. Several exhibited a considerable degree of sequence variation at the nucleotide and limited divergence at the amino acid levels within the various functional domains. The results suggest that the cDNAs isolated represented a single myosin heavy chain, which, by comparison with a number of other myosins, is inferred to represent a homologue of a muscle myosin (CeMHCA) of the free-living nematode Caenorhabditis elegans. The findings could have implications for investigating cytoskeletal dynamics and/or signalling pathways.
Primary Industries Research Victoria, 475 Mickleham Road, Attwood, Victoria 3049, Australia.
S
S
Nikolaou
M
M
Hu
N B
NB
Chilton
D
D
Hartman
A J
AJ
Nisbet
P J A
PJ
Presidente
R B
RB
Gasser
D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary; D018509:DNA, Helminth / Q000032:analysis; D017238:Genes, Helminth; D006189:Haemonchus / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009218:Myosins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D009348:Nematoda / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; D018509:DNA, Helminth; D009218:Myosins