Prenatal diagnosis of a giant congenital primary cerebral hemangiopericytoma.
Congenital primary intracranial hemangiopericytomas are exceptionally rare tumors. We present a case of a fetus, with the prenatal sonogram at 33 weeks of gestation revealing a large cerebral tumor. Because of the enlarged head, a cesarean section was performed. The tumor was confirmed by postnatal ultrasound, magnetic resonance imaging (MRI) and biopsy. Elevated intracranial pressure and hemorrhage led to death on the 11th day. Autopsy revealed a 10x9 cm large inhomogeneous tumor located centrally, mainly in the posterior fossa. Histology showed a hypercellular and hypervascular tumor with extended necrosis and high mitotic rate. The tumor cells were positive for vimentin and CD34 antigens and negative for several neurological markers, desmin and CD31. The diagnosis of a congenital primary cerebral hemangiopericytoma was confirmed.
Sobel
Gábor
G
2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Halász
Judit
J
Bogdányi
Katalin
K
Szabó
István
I
Borka
Katalin
K
Molnár
Péter
P
Schaff
Zsuzsa
Z
Paulin
Ferenc
F
Bánhidy
Ferenc
F
D000328:Adult; D005260:Female; D006393:Hemangiopericytoma / Q000151:congenital* / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D015192:Infratentorial Neoplasms / Q000151:congenital* / Q000175:diagnosis*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal