Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions.
2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.
Babaev
Eugene V
EV
Department of Chemistry, Moscow State University, 119992, Moscow, Russia. babaev@org.chem.msu.su
Vasilevich
Natalya I
NI
Ivushkina
Anna S
AS