[Alloimmunization to a high frequency Rh antigen].
We report the case of a pregnant woman sensitized with a panreactive anti-Rh17 alloantibody. Patient's red blood cells showed a partial deletion of Rh antigens, which was responsible for the alloimmunization. An autotransfusion program was instrumented so as to cover possible demands. Molecular analysis of the RH locus showed the presence of a hybrid RHCE-D(5-7)-CE allele that gave origin to the deleted phenotype.
Cotorruelo
Carlos
C
Laboratorio de Inmunohematología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina. ccotorru@fbioyf.unr.edu.ar
Biondi
Claudia
C
Borras
Silvia Garcia
SG
Racca
Liliana
L
Brunetti
Daniel
D
Di Monaco
Rene
R
Racca
Amelia
A
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000276:immunology; D005838:Genotype; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D010641:Phenotype; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000276:immunology*; D012203:Rh Isoimmunization / Q000097:blood / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*
D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System