New cytotoxic tetrahydrofuran- and dihydrofuran-type lignans from the stem of Beilschmiedia tsangii.
Five new compounds including two tetrahydrofuran-type lignans, beilschmin A and beilschmin B, a dihydrofuran-type lignan, beilschmin C, and two 1-phenylbutyl benzoates, tsangin A and tsangin B, together with thirteen known compounds have been isolated from the stem of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (1), beilschmin B (2), beilschmin C (3), tsangin A (4), tsangin B (5), 2,6,11-trimethyldodeca-2,6,10-triene (14), alpha-tocopherylquinone (17), and alpha-tocospiro B (18) were cytotoxic (IC (50) values < 4 microg/mL) in P-388 and/or HT-29 cell lines in vitro.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, Republic of China. jjchen@mail.tajen.edu.tw
Chou
En-Tzu
ET
Duh
Chang-Yih
CY
Yang
Sheng-Zehn
SZ
Chen
Ih-Sheng
IS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D019770:Lauraceae; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D017705:Lignans; D010936:Plant Extracts