Role of frequency doubling technology perimetry in screening of diabetic retinopathy.
OBJECTIVE
To study the ability of frequency-doubling technology perimetry (FDT) to detect sight-threatening diabetic retinopathy.


METHODS
Fifty-eight eyes of fifty-eight patients with established diagnosis of diabetes mellitus with diabetic retinopathy, fifty-five eyes of fifty-five diabetic patients without retinopathy and forty-one eyes of forty-one normals underwent FDT and dilated stereo-biomicroscopic fundus examination. The sensitivity and specificity of FDT in identification of "sight-threatening retinopathy" (severe and very severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy) and clinically significant macular edema (CSME) were determined.


RESULTS
For the detection of sight-threatening retinopathy, two abnormal adjacent points depressed to any level on the 20-1 screening program had a sensitivity of 90.5% and specificity of 97.6%. At (assuming a) 10% prevalence of sight-threatening retinopathy in a diabetic clinic, two abnormal adjacent points anywhere in the field depressed to any level has a positive predictive value (PPV) of 48% with a negative predictive value of 98.8%. Sensitivity and specificity for the detection of CSME was poor.


CONCLUSIONS
The 20-1 screening program of the FDT is useful in the detection of sight-threatening diabetic retinopathy (PPV 48%). A normal 20-1 test rules out sight-threatening retinopathy. FDT was not useful in the detection of CSME.
Parikh
Rajul
R
Schell Eye Hospital, Christian Medical College, Vellore, India.
Naik
Milind
M
Mathai
Annie
A
Kuriakose
Thomas
T
Muliyil
JayaPrakash
J
Thomas
Ravi
R
D000328:Adult; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015351:Vision Screening; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields