Leanness, smoking, and enhanced oxidative DNA damage.
An increased risk of some forms of cancer, including lung cancer, among lean individuals has been consistent; however, there is a paucity of biological evidence supporting this relation. Subjects analyzed were 177 healthy Japanese workers who participated in a lifestyle intervention study. The levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, were measured using an automated high-pressure liquid chromatography and urinary creatinine levels were adjusted for before statistical analysis. A clear inverse association was found between body mass index (BMI) and 8-OHdG levels among smokers [Pearson correlation coefficient (r) = -0.48], and the association did not materially change after adjustment for potential confounding factors. In contrast, no apparent relation was observed between BMI and 8-OHdG levels among nonsmokers (r = -0.12), although lean nonsmokers had a slightly higher mean of 8-OHdG levels compared with nonlean nonsmokers. The interaction of smoking and BMI reached statistical significance (P = 0.04). Leanness may enhance oxidative DNA damage induced by smoking and thus serve as a marker of host susceptibility to smoking-related cancers.
Mizoue
Tetsuya
T
Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, 812-8582 Fukuoka, Japan. mizoue@phealth.med.kyushu-u.ac.jp
Kasai
Hiroshi
H
Kubo
Tatsuhiko
T
Tokunaga
Shoji
S
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004249:DNA Damage / Q000235:genetics / Q000502:physiology*; D003849:Deoxyguanosine / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress; D011336:Probability; D016016:Proportional Hazards Models; D012016:Reference Values; D012680:Sensitivity and Specificity; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013851:Thinness; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
D015415:Biomarkers; D003849:Deoxyguanosine