Multimodal strategies for resuscitating injured cells.
Our cells and tissues are challenged constantly by exposure to extreme conditions that cause acute and chronic stress. Wounding at the cellular level is a common event, and results from cell exposure to supra-physiologic forces, or is the consequence of action by reactive chemical agents. An individual cellular wound results from either the alteration of protein or DNA structure, or the disruption of molecular assemblies, the most important of which is the cell's membranes. Tissue healing at the macroscopic level is a complex and coordinated process involving many different cell types while, in contrast, the wounds of individual cells heal primarily via biomolecular interactions. Like tissue wound healing, cellular wound healing involves the upregulation or acceleration of processes that are constitutively expressed in routine physiologic repair of cellular structures In addition, recent advances have been made in the identification of pharmaceutical strategies to aid the cellular repair response. Many of these strategies offer promise for augmenting the already present cellular repair mechanisms.
Section of Plastic and Reconstructive Surgery, University of Chicago Hospitals, 5841 S. Maryland Ave., MC 6035, Chicago, IL 60637, USA.
Jayant
J
Agarwal
Alexandra
A
Walsh
Raphael C
RC
Lee
D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D007035:Hypothermia / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D015394:Molecular Structure; D011487:Protein Conformation; D011489:Protein Denaturation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013501:Surface-Active Agents / Q000737:chemistry; D014945:Wound Healing
D008051:Lipid Bilayers; D018832:Molecular Chaperones; D011506:Proteins; D013501:Surface-Active Agents