Minor alkaloids from Guatteria dumetorum with antileishmanial activity.
Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine ( 3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1-4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.
Correa
Jhonny Edmith
JE
Laboratorio de Bioorgánica Tropical, Universidad de Panamá, República de Panamá.
Ríos
Carlos Hernán
CH
del Rosario Castillo
Amparo
A
Romero
Luz I
LI
Ortega-Barría
Eduardo
E
Coley
Phyllis D
PD
Kursar
Thomas A
TA
Heller
Maria Verónica
MV
Gerwick
William H
WH
Rios
Luis Cubilla
LC
D000818:Animals; D002522:Chlorocebus aethiops; D031043:Guatteria; D006801:Humans; D007894:Leishmania mexicana / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells / Q000187:drug effects
D010936:Plant Extracts; D014344:Trypanocidal Agents