Bilateral axillary metastasis from a primary ethmoidal squamous cell carcinoma.
The development of infra-clavicular lymph node metastasis from head and neck squamous cell carcinoma is an uncommon event. We present a rare case of bilateral axillary nodal metastasis that developed in a patient previously treated for a primary ethmoidal squamous cell carcinoma. To our knowledge, there have only been five case reports in the English literature, accounting for a total of 10 patients, which documented a clinically apparent metastasis to axillary lymph nodes from various head and neck malignancies. Significantly however, the simultaneous ipsilateral and contralateral lymphatic spread of disease from a tumour in the para-nasal sinus, so as to involve bi-axillary nodes, has not been previously reported. We discuss the possible pathogenesis and the prognostic significance of this manifestation.
University Hospitals of Coventry & Warwickshire NHS Trust, Coventry, UK. drshafiqislam@hotmail.co.uk
S
S
Islam
C V
CV
Cole
G R
GR
Hoffman
P A
PA
Brennan
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001365:Axilla; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D005005:Ethmoid Sinus; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy; D010255:Paranasal Sinus Neoplasms / Q000601:surgery / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed
D002945:Cisplatin; D005472:Fluorouracil