[Study on the reproductive effects of carbon disulfide in male rats and their subgeneration].
OBJECTIVE
To study reproductive toxicity of carbon disulfide and the effects of their subgeneration.


METHODS
40 male rats were randomly divided into four groups. It took ten weeks for the rats to breath CS2 in different densities (0, 50, 250, 1250 mg/m3). Five rats were randomly chosen from the controlling group, high and low dosage group, put them together with female rats for copulation in the ninth week. We observed the pregnant rates, miscarry counts, resorption counts, the numbers and body weight of their subgeneration, weight of the placenta, length of the body, length of the tail, length of the belly, the distance from the rectum to the genital, the effects of the sketetion and the purtenunce. In the eleventh weeks, we measured testide coefficient and testide horizontal of male rats, epididymal weight, sperm count, sperm motility and its classification, the ratio of sperm deformity, etc.


RESULTS
The pregnant rats of the dosage groups were all lower than the control group, but the differences were not statistically significant. The data of the high dosage group was obviously lower than the control group (P < 0.05 or P < 0.01). The body weight and the organ coefficient were all lower than the control group, but only brain coefficient of the high group between the control group were statistically significant (P < 0.05). Teside coefficient of the high dosage group obvioulsly decreased than the control group (P < 0.05). Epididymal weight, sperm count, sperm molitity and incidence rate of ospermia of middle and high dosage group obviously decreased than control group.


CONCLUSIONS
The effects of CS2 in distortion rate and abnormal data of growth are possibly related to the decrease in sperm quality and quantity.
Chen
Guo-yuan
GY
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Deng
Jing
J
Tan
Hao
H
Chai
Lian-hua
LH
D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D005260:Female; D008297:Male; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D004785:Environmental Pollutants; D002246:Carbon Disulfide