Mechanical characterization and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anesthesia.
In the development of bioadhesive patch devices for percutaneous local anesthesia, the tensile properties of the films produced after the casting of the gel intermediates is of key importance to the clinical compliance of the product, and its effective delivery of the local anesthetic agent. A range of bioadhesive patches were formulated and their mechanical and in vitro permeation properties determined. Altering formulation significantly altered the mechanical properties of films. The tensile properties of the films could be modified to allow concomitant benefits in the mechanical and drug permeation properties of the films, ensuring that patches not only exerted clinically beneficial effects, but are also mechanically robust. Tetracaine was found to plasticize films and while this effect was weak, it was significant both statistically and potentially also in the effect it has on the clinical use of these devices. Drug release from tetracaine patches demonstrate the same trends as found previously across polydimethylsiloxane films. By altering the formulation of the patch device, the drug release from the device to the skin is readily and accurately controlled, and was not solely a function of the stratum corneum barrier properties but additionally of the formulation.
Moss
G P
GP
School of Pharmacy and Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK. g.p.j.moss@herts.ac.uk
Gullick
D R
DR
Woolfson
A D
AD
McCafferty
D F
DF
D000269:Adhesives; D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers; D004548:Elasticity; D005990:Glycerol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008298:Maleates / Q000737:chemistry*; D010539:Permeability; D011095:Polyethylenes / Q000737:chemistry*; D013718:Tensile Strength; D013748:Tetracaine / Q000737:chemistry*
D000269:Adhesives; D000779:Anesthetics, Local; D004337:Drug Carriers; D008298:Maleates; D011095:Polyethylenes; D013748:Tetracaine; D002482:Cellulose; C002283:hydroxyethylcellulose; C043105:poly(methyl vinyl ether-co-maleic anhydride); D005990:Glycerol