Dendritic cell-T cell interactions in the generation and maintenance of CD8 T cell memory.
Dendritic cells (DCs) are the critical antigen-presenting cells involved in initiating CD8 T cell responses to microbial and viral pathogens. Hence the generation of memory T cells from naïve T cells is intricately intertwined with DCs at every level. This review broadly addresses DC-CD8 T cell interactions that result in the generation and maintenance of CD8 memory T cells.
Department of Immunology, University of Connecticut Health Center, M/C 1319, 263 Farmington Avenue, Farmington, CT 06030, USA.
David J
DJ
Zammit
Leo
L
Lefrançois
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D002455:Cell Division; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000166:cytology / Q000382:microbiology*; D014777:Virus Diseases / Q000276:immunology