Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp.
Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.
Department of Medicine 0665, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0665, USA.
Yolanda S
YS
Andersen
Frances D
FD
Gillin
Lars
L
Eckmann
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology; D004195:Disease Models, Animal; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000276:immunology*; D005873:Giardiasis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology; D007110:Immunity, Active; D008139:Loperamide / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016513:Mice, SCID; D052248:Nitric Oxide Synthase Type I / Q000172:deficiency / Q000235:genetics
D000930:Antidiarrheals; D008139:Loperamide; D052248:Nitric Oxide Synthase Type I