Mitosis: riding the protofilament curl.
More than 50 years ago, microtubule depolymerization was proposed as the force responsible for chromosome movement. New studies measure the force produced by depolymerization and show that protein ring complexes can couple depolymerization to movement. These results have implications for anaphase chromosome motility and mitotic evolution.
Department of Biological Sciences, 111 Research Drive, Lehigh University, Bethlehem, Pennsylvania 18015, USA. lc07@lehigh.edu
Lynne
L
Cassimeris
D000705:Anaphase / Q000502:physiology; D001692:Biological Transport; D018797:Cell Cycle Proteins / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism*; D003198:Computer Simulation; D005656:Fungal Proteins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D008938:Mitosis; D008954:Models, Biological; D004718:Saccharomycetales / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D008869:Microtubule-Associated Proteins; D014404:Tubulin