Defect of oral tolerance in NC/Nga mice.
The NC/Nga mouse is a model animal for human atopic dermatitis. In this study, we investigated oral tolerance induction in NC/Nga mice. In BALB/c mice, oral administration of ovalbumin (OVA) resulted in suppression of both OVA-specific T and B cell responses induced by OVA immunization. In NC/Nga mice, OVA-induced antigen (Ag) -specific T and B cell responses were significantly less than those in BALB/c mice. Furthermore, oral administration of OVA did not suppress OVA-specific immunoresponses in NC/Nga mice. We further examined antibody (Ab) response against food Ag by feeding mice an experimental diet that contained OVA or casein as a protein source. The level of serum OVA or casein-specific IgG was significantly higher in NC/Nga mice than in BALB/c mice. These results indicate that NC/Nga mice have a defect in the induction of oral tolerance. NC/Nga mice can therefore be used as a model for investigating the mechanism of oral tolerance.
Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School, Japan.
Tohru
T
Sakai
Mari
M
Kogiso
Kaori
K
Mitsuya
Tatushi
T
Komatsu
Shigeru
S
Yamamoto
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D002364:Caseins / Q000008:administration & dosage / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000097:blood; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D018448:Models, Immunological; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D002364:Caseins; D007074:Immunoglobulin G; D010047:Ovalbumin