Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.
Koivisto
Anne M
AM
Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland. anne.koivisto@kuh.fi
Helisalmi
Seppo
S
Pihlajamäki
Jussi
J
Moilanen
Leena
L
Kuusisto
Johanna
J
Laakso
Markku
M
Hiltunen
Mikko
M
Keijo
Koivisto
K
Hänninen
Tuomo
T
Helkala
Eeva-Liisa
EL
Kervinen
Kari
K
Kesäniemi
Y Antero
YA
Soininen
Hilkka
H
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005387:Finland; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015850:Interleukin-6