The view from the biochemist. Comment on "Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs" by Arndt Benecke.
The review by Arndt Benecke focuses on chromatin, a major hallmark of eukaryotic life. The dynamic of chromatin and its underlying mechanisms are discussed. In addition, theoretical properties of chromatin associated with transcriptional regulation are presented. In the present brief comment on the review by Arndt Benecke, we wish to provide additional information regarding chromatin structure and in particular on the so-called "histone code hypothesis". We will discuss about the emerging idea that chromatin structure is much more complex than previously thought. The possibility that chromatin modifications may play important roles in biology beside transcriptional regulation will also be put forward.
Faculty of Medicine, Laboratory of Molecular Virology, Free University of Brussels, 808 route de Lennik, 1070, Brussels, Belgium. ffuks@ulb.ac.be
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D002843:Chromatin / Q000737:chemistry / Q000235:genetics*; D005815:Genetic Code; D007700:Kinetics; D014158:Transcription, Genetic
D002843:Chromatin