[CT perfusion in evaluation of cerebral hemodynamics in carotid artery stenosis].
OBJECTIVE
To study the clinical value of multi-slice spiral CT (MSCT) perfusion technique in evaluation of cerebral hemodynamics in patients with severe carotid stenooclusive lesions.


METHODS
Twenty-three patients with severe carotid stenosis were enrolled for evaluation of cerebral hemodynamics, including 12 patients with carotid occlusion and 11 with severe carotid stenosis (> 70%). Among them, 16 patients had multiple arterial diseases, including contralateral carotid stenosis, vertebral arteries stenosis, and cerebral arteries stenosis or occlusion. All patients received CT perfusion examination. Ten normal persons received CT perfusion were regarded as the control group.


RESULTS
Cerebral perfusion was bilaterally symmetrical in 10 normal persons. While in the patients group, cerebral hemodynamic impairments ipsilateral to the stenosis side were found by CT perfusion in 17 patients, including an delay of time to peak (TTP) (17 patients), increase of cerebral blood volume (CBV) (7 patients), and decrease of cerebral blood flow (CBF) (4 patients). No significant difference was found between occlusion group (n = 8) and stenosis group (n = 9) (P = 0.640), but incidences of hemodynamic impairment were significantly higher in multiple arterial diseases group (n = 14) than single arterial disease group (n = 3) (P = 0.045).


CONCLUSIONS
CT perfusion technique can sensitively reveal the cerebral hemodynamic impairments in patients with severe carotid stenooclusive diseases, and therefore valuable for clinical application.
Li
Ming-li
ML
Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Jin
Zheng-yu
ZY
Zhang
Xiao-bo
XB
Gao
Shan
S
Lu
Jing-jing
JJ
Xue
Hua-dan
HD
Zhao
Wen-min
WM
Wang
Yun
Y
Zhang
Yun-qing
YQ
D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000379:methods*