[Immunological aspects of atherosclerosis].
The pathogenesis of atherosclerosis remains incompletely understood. Accumulation of oxidized lipoproteins (oxLDL) within the vascular wall drives a related immune response very early during the disease course. Such an immune response is self-amplified and eventually escapes from physiologic control mechanisms. Certain lymphocytes may become pathogenic. B cells play a protective role by producing antibodies able to neutralize oxLDL. Elucidation of the immune control mechanisms in atherosclerosis will open the way to new therapeutic perspectives.
Inserm U681, Université Pierre et Marie Curie - Paris VI, Institut des Cordeliers.
Emilie
E
Groyer
Giuseppina
G
Caligiuri
Jamila
J
Laschet-Khallou
Antonino
A
Nicoletti
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D001057:Apolipoproteins E / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology*; D003324:Coronary Artery Disease / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D017152:Antibodies, Antiphospholipid; D001057:Apolipoproteins E; D015704:CD4 Antigens; D016207:Cytokines; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D007371:Interferon-gamma