Cerebellar medullomyoblastoma with melanotic tubular structures.
This report describes a midline cerebellar primitive neuroectodermal tumor with muscular differentiation, that is, medullomyoblastoma with melanotic tubular structures, which developed in the cerebellar vermis in a 23-month-old male. Rhabdomyoblastic differentiation consisted both of striated muscle fibers and undifferentiated cells showing immunoreactivity for desmin and myogenic transcription factors. The presence of melanotic epithelial structures raised the issue of a teratomatous tumor. This case demonstrates the occurrence of this very rare tumor in early childhood as well as the utility of a careful search for the presence of myogenic and/or melanotic features in medulloblastomas.
Nozza
Paolo
P
U.O. di Anatomia Patologica, Istituto Giannina Gaslini, Genova, Italia. paolonozza@ospedale-gaslini.ge.it
Milanaccio
Claudia
C
Piatelli
Gianluca
G
Rossi
Andrea
A
Raso
Alessandro
A
Cama
Armando
A
Garré
Maria L
ML
Pietsch
Torsten
T
D002528:Cerebellar Neoplasms / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000473:pathology*; D009379:Neoplasms, Muscle Tissue / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology*