Effect of short-acting inhaler beta2-agonists on serum cardiac troponin in wheezy infant.
Cardiac troponin (cTn) is highly specific for myocardial injury. However, effect of beta2-agonist therapy on cTn in wheezy infants is unknown. We aimed to assess serum troponin in children with wheezy infant treated by short-acting inhaler beta2-agonists. Twenty-four children, under 5 years old, with the diagnosis of wheezy infant with acute exacerbation were enrolled in the study. Subjects were treated three times by a standard dose of nebulized salbutamol (0.15 mg/kg per dose; maximum, 3 mg; Ventolin Nebules Ampule) therapy. The heart rate, respiratory rate, cTnI, creatine kinase (CK), CK-MB levels, and electrocardiogram were measured in wheezy infant before and after 60-minute nebulized salbutamol. In the control group the heart rate, respiratory rate, cardiac troponin I (cTnI), CK, CK-MB levels, and electrocardiogram were recorded at admission. For Seventeen boys (70.8%) and seven girls (29.2%) with wheezy infant, the mean age of the patients was 21.4 +/- 18.13 months and for control groups the mean age was 17.28 +/- 16.09 months (p = 0.419). There was no significant difference in serum troponin in patients before treatment, after treatment period, and in controls (mean +/- SD, 0.049 +/- 0.03, 0.043 +/- 0.048, and 0.044 +/- 0.034, respectively; p = 0.14, p = 0.72, and p = 0.35, respectively). Short-acting inhaler 32-agonists do not influence circulating troponin levels in wheezy infant with acute attack.
Taşar
M Ayşin
MA
Departments of Pediatrics, Ministry of Healthy Ankara Education and Research Hospital, Ankara, Turkey.
Bostanci
Ilknur
I
Atli
Ozlem
O
Dallar
Yildiz
Y
D000208:Acute Disease; D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D004562:Electrocardiography; D006801:Humans; D007223:Infant; D009206:Myocardium / Q000378:metabolism; D009330:Nebulizers and Vaporizers; D012135:Respiratory Sounds / Q000187:drug effects* / Q000502:physiology; D019210:Troponin I / Q000097:blood*
D000318:Adrenergic beta-Agonists; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D000420:Albuterol