Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats.
OBJECTIVE
To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats.


METHODS
Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis.


RESULTS
Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde.


CONCLUSIONS
Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Tae Woo
TW
Jung
Ji Young
JY
Lee
Wan Sub
WS
Shim
Eun Seok
ES
Kang
Soo Kyung
SK
Kim
Chul Woo
CW
Ahn
Hyun Chul
HC
Lee
Bong Soo
BS
Cha
D000818:Animals; D015153:Blotting, Western; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000097:blood; D003484:Cyanamide / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015151:Immunoblotting; D007398:Interpersonal Relations; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077154:Rosiglitazone; D012919:Social Behavior; D045162:Thiazolidinediones / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
D002492:Central Nervous System Depressants; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000431:Ethanol; D003484:Cyanamide