Thrombolytic therapy of acute ischemic stroke during pregnancy.
The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.
Murugappan
A
A
Stroke Program, Department of Neurology, Wayne State University, School of Medicine, Detroit, MI, USA.
Coplin
W M
WM
Al-Sadat
A N
AN
McAllen
K J
KJ
Schwamm
L H
LH
Wechsler
L R
LR
Kidwell
C S
CS
Saver
J L
JL
Starkman
S
S
Gobin
Y P
YP
Duckwiler
G
G
Krueger
M
M
Rordorf
G
G
Broderick
J P
JP
Tietjen
G E
GE
Levine
S R
SR
D000328:Adult; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator