Rewetting drops containing surface active agents improve the clinical performance of silicone hydrogel contact lenses.
OBJECTIVE
The purpose of this study was to investigate the impact of using a rewetting drop (RWD) containing surface active agents (OPTI-FREE RepleniSH; Alcon, Fort Worth, TX) on the clinical performance and protein deposition when using a continuous-wear (CW) silicone hydrogel (SH) contact lens.


METHODS
Subjects wore lotrafilcon A SH lenses on a 30-day CW basis for two consecutive 1-month periods while inserting either 0.9% unpreserved unit-dose saline (control) or multidose OPTI-FREE RepleniSH (test RWD). Subjective comfort and symptoms were assessed after 2 and 4 weeks with each product. After 1 month of wear with each product, lenses were collected and analyzed in the laboratory for total protein, total lysozyme, and percentage of denatured lysozyme.


RESULTS
Symptoms of dryness and comfort varied across the day regardless of drop type (p < 0.001) with dryness being maximal on waking, least in the middle of the day, and increased towards the evening. The test RWD provided greater comfort on insertion (p = 0.02), better visual quality (p < 0.01), and less mucous discharge on waking (p = 0.02) than the control product. Lysozyme deposition was significantly reduced after the use of the test RWD as compared to saline (0.73 +/- 0.5 microg/lens vs. 1.14 +/- 0.7 microg/lens; p < 0.001) as was total protein deposition (1.17 +/- 0.7 microg/lens vs. 1.86 +/- 0.8 microg/lens; p < 0.001). Lysozyme denaturation was also reduced with the use of the test RWD compared with the control (76 +/- 10% vs. 85 +/- 7%; p < 0.01).


CONCLUSIONS
The use of a RWD containing surface active agents provided greater subjective satisfaction, reduced lysozyme and total protein deposition, and reduced denatured lysozyme than a RWD containing saline alone.
Subbaraman
Lakshman N
LN
Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada.
Bayer
Simone
S
Glasier
Mary-Ann
MA
Lorentz
Holly
H
Senchyna
Michelle
M
Jones
Lyndon
L
D000328:Adult; D015153:Blotting, Western; D003262:Contact Lenses, Extended-Wear; D018592:Cross-Over Studies; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000517:prevention & control*; D004591:Electrophoresis, Polyacrylamide Gel; D005500:Follow-Up Studies; D006801:Humans; D020100:Hydrogels; D009113:Muramidase / Q000032:analysis; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D011474:Prosthesis Design; D012030:Refractive Errors / Q000628:therapy*; D012828:Silicones; D013501:Surface-Active Agents / Q000008:administration & dosage*; D013666:Tears / Q000737:chemistry; D016896:Treatment Outcome; D005466:Fluorocarbons
D020100:Hydrogels; D009113:Muramidase; D009883:Ophthalmic Solutions; D012828:Silicones; D013501:Surface-Active Agents; C481129:lotrafilcon A; D005466:Fluorocarbons