Efficient route to 4a-methyltetrahydrofluorenes: a total synthesis of (+/-)-dichroanal B via intramolecular Heck reaction.
An efficient new route based on intramolecular Heck cyclization of the diene 11 was developed to prepare the 4a-methyltetrahydrofluorene diterpenoids and utilized for the total synthesis of (+/-)-dichroanal B with significantly improved overall yield.
Planas
Loïc
L
Department of Pharmaceutical Manufacturing Chemistry, 21 Century COE program, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan.
Mogi
Muneto
M
Takita
Hirofumi
H
Kajimoto
Tetsuya
T
Node
Manabu
M
D000447:Aldehydes / Q000737:chemistry; D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D004224:Diterpenes; D005449:Fluorenes; C516118:beta-cyclocitral