Preliminary evaluation of 99mTechnetium diethylenetriamine pentaacetic acid, 99mTechnetium dimercaptosuccinic acid, and 99mTechnetium mercaptoacetyltriglycine for renal scintigraphy in corn snakes (Elaphe guttata guttata).
The efficacy of three radiopharmaceuticals, 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA), 99mTc-dimercaptosuccinic acid (99mTc-DMSA), and 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), for renal imaging was examined in 16 corn snakes (Elaphe guttata guttata). All snakes received the radiopharmaceutical via an intracardiac injection. The kidneys could not be visualized in the three snakes that received 99mTc-DTPA or in the three snakes that received 99mTc-DMSA, but were well delineated in all 10 snakes receiving 99mTc-MAG3. These snakes were anesthetized and a dynamic frame mode acquisition was obtained for 30 min immediately following injection. A 60 s single static frame mode image was then obtained with the snake in a curled position. Two of the 10 snakes that received 99mTc-MAG3 were removed from further analysis because of suspected pericardial injections. Of the remaining eight snakes, the mean (+/- SD) renal uptake was 25 +/- 9.8% or 24 +/- 9.7%, with or without correction for residual injection site activity, respectively. Correction for remaining radioactivity in the heart does not appear to be necessary if it is less than 10% of the total dose. 99mTc-MAG3 provided consistently high quality images of the kidneys and further studies are warranted to evaluate its sensitivity for detecting decreased function in snakes with renal disease.
Department of Small Animal Clinical Sciences, C 247 Veterinary Teaching Hospital, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. jsykes3@utk.edu
John M
JM
Sykes
Juergen
J
Schumacher
James
J
Avenell
Edward
E
Ramsay
Gregory B
GB
Daniel
D000818:Animals; D005260:Female; D006321:Heart; D007267:Injections / Q000662:veterinary; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging / Q000662:veterinary; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012911:Snakes / Q000378:metabolism*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D017263:Technetium Tc 99m Mertiatide / Q000008:administration & dosage / Q000493:pharmacokinetics; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage / Q000493:pharmacokinetics
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016284:Technetium Tc 99m Pentetate