Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei.
Three novel three-membered ring sesquiterpenoids, named kissoone A (1), kissoone B (2), and its acetylated product, kissoone C (3), were isolated from the roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC 12D cells.
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Yuanqiang
Y
Guo
Jing
J
Xu
Yushan
Y
Li
Tohru
T
Yamakuni
Yasushi
Y
Ohizumi
D000818:Animals; D004305:Dose-Response Relationship, Drug; D020932:Nerve Growth Factor / Q000502:physiology*; D016501:Neurites / Q000187:drug effects* / Q000378:metabolism; D016716:PC12 Cells / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014632:Valerian
D010936:Plant Extracts; D012717:Sesquiterpenes; D020932:Nerve Growth Factor