BHV-1 vaccine induces cross-protection against BHV-5 disease in cattle.
Protection against BHV-5 disease induced by inactivated BHV-1 or BHV-5 based vaccines was analysed. Two groups of calves were subcutaneously immunized with an inactivated BHV-1 or BHV-5 based vaccine. A third group was not vaccinated and used as control. In the post-vaccination period, we studied the humoral and cellular immune response resulting similar to both groups. The efficacy of the vaccines was tested after intranasal challenge of the calves with a virulent Argentinean BHV-5 isolate (A-663). All control animals developed neurological signs associated with BHV-5 infection and high levels of virus shedding. Calves immunized with the BHV-1 and BHV-5 inactivated vaccines were protected against BHV-5 disease. Our study provides evidence that strongly support the existence of cross-protection between BHV-1 and BHV-5 in calves. Even though this has already been suggested by previous works, this is the first time an exhaustive study of the immune response is performed and typical clinical BHV-5 meningoencephalitis signs are reproduced in an experimental BHV-5 challenge trial.
Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), Instituto Nacional de Tecnología, Agropecuaria (INTA), Castelar, CC77, 1708 Morón, Argentina. pdelmedico@cicv.inta.gov.ar
M P
MP
Del Médico Zajac
M
M
Puntel
P I
PI
Zamorano
A M
AM
Sadir
S A
SA
Romera
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D002460:Cell Line; D018792:Encephalitis, Viral / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D025881:Herpesvirus 5, Bovine / Q000276:immunology*; D008590:Meningoencephalitis / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D009500:Neutralization Tests / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology*; D017201:Virus Shedding
D000914:Antibodies, Viral; D014765:Viral Vaccines