Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice.
Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.
Maeno
Yoshimasa
Y
Department of Virology and Parasitology, Fujita Health University School of Medicine, 1-98 Kutsukake, Toyoake, Aichi 470-1192, Japan. ymaeno@fujita-hu.ac.jp
Nakazawa
Shusuke
S
Yamamoto
Naoki
N
Shinzato
Masanori
M
Nagashima
Shigeo
S
Tanaka
Kumiko
K
Sasaki
Jun
J
Rittling
Susan R
SR
Denhardt
David T
DT
Uede
Toshimitsu
T
Taniguchi
Koki
K
D000818:Animals; D005434:Flow Cytometry; D007113:Immunity, Innate / Q000235:genetics; D007371:Interferon-gamma / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D007700:Kinetics; D008288:Malaria / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053495:Osteopontin; D016788:Plasmodium chabaudi / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis; D012795:Sialoglycoproteins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018417:Th1 Cells / Q000276:immunology* / Q000469:parasitology
D012333:RNA, Messenger; D012795:Sialoglycoproteins; C506896:Spp1 protein, mouse; D053495:Osteopontin; D018664:Interleukin-12; D007371:Interferon-gamma