[Acute intoxication due to cocaine. Review of one case].
Cocaine is a drug with distribution and consumption throughout the world. Its consumption extended mainly in the decades 1980-1990. The drugs produces cardiovascular effects following chronic administration and overdose, due to their potent vasoconstrictor effect secondary to the increase of synaptic concentrations of the monamine neurotransmitter dopamine, norepinephrine, and serotonin by binding to transporter proteins and blocking reuptake. Renal insufficiency due to rhabdomyolysis, and cardiovascular dysfunction have been reported following cocaine abuse, and may be fatal. We report a patient who developed renal insufficiency due to rhabdomyolysis and a cardiovascular disorder associated with cocaine abuse. We review the disorders induced by cocaine abuse and their treatment.
Solano Remírez
M
M
Servicio de Medicina Interna, Hospital de Navarra, Pamplona, Spain. manoloso@eresmas.com
Velilla Alcubilla
J P
JP
Alvarez Frías
M T
MT
D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D006801:Humans; D008297:Male; D011654:Pulmonary Edema / Q000209:etiology*; D051437:Renal Insufficiency / Q000209:etiology*; D012206:Rhabdomyolysis / Q000209:etiology*