Evaluation of antinociceptive and anti-inflammatory effects of venlafaxine in the rat.
The aim of this study was to test antinociceptive properties of venlafaxine in rats with carrageenan-induced pain and inflammation. Pain was provoked with carrageenan (1%) injection into the plantar surface of the rat paw-pad. The effect of venlafaxine on carrageenan-induced mechanical hypersensitivity, mechanical stimulation response (the von Frey monofilament test) as well as the size of carrageenan-induced paw edema were tested at 2 to 24 hours following the toxin injection into the rat paw-pad. Pretreatment with venlafaxine significantly reduced or completely abolished the enhanced sensitivity to mechanical stimuli provoked by peripheral carrageenan injection. The study demonstrated the efficacy of peripherally applied venlafaxine pretreatment on the pain component of inflammatory process.
University of Marmara, Faculty of Pharmacy, Department of Pharmacology and Psychopharmacology Research Unit, Istanbul, Turkey. faricioglu@marmara.edu.tr
Feyza
F
Aricioğlu
Ulaş
U
Buldanlioğlu
Gamze
G
Salanturoğlu
Nuri Süleyman
NS
Ozyalçin
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002351:Carrageenan; D003511:Cyclohexanols / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D000069470:Venlafaxine Hydrochloride
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride; D002351:Carrageenan