Oleic acid-associated bronchiolitis obliterans-organizing pneumonia in beagle dogs.
Accidental intra-airway exposure of dogs with pure oleic acid produced bronchiolitis obliterans and bronchopneumonia. Pulmonary changes included multifocal to coalescing necrosis of bronchioles and adjacent alveoli, hemorrhage, inflammation, and exudation of fibrin. Hyperplasia of bronchiolar and alveolar epithelial cells and proliferation of loose fibrovascular connective tissue formed polyps or plugs of variable size and shape. Polyps in the airways primarily consisted of fibroblasts with loose or myxoid stroma and were variably covered with attenuated epithelial cells. Some polyps had prominent vasculature, mixed inflammatory cell infiltration, and/or necrosis. Polyps or plugs variably effaced bronchioles and adjacent alveoli. The changes closely resembled human bronchiolitis obliterans-organizing pneumonia (BOOP). Controlled intra-airway delivery of oleic acid in dogs may be a potential animal model of obstructive pulmonary diseases such as BOOP or bronchiolitis obliterans.
Li
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X
Pfizer WW Safety Sciences, 2800 Plymouth Road, Bldg. 50, Ann Arbor, MI 48105, USA. xiantang.li@pfizer.com
Botts
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S
Morton
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D
Knickerbocker
M J
MJ
Adler
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R
D000818:Animals; D018549:Cryptogenic Organizing Pneumonia / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D008168:Lung / Q000473:pathology; D008297:Male; D019301:Oleic Acid / Q000009:adverse effects*
D019301:Oleic Acid