Visceral Leishmania donovani infection in interleukin-13-/- mice.
Leishmania donovani-infected interleukin-13-/- BALB/c mice showed impaired initial gamma interferon secretion and incomplete granuloma assembly at parasitized liver foci. Nonetheless, control of early parasite replication, resolution of liver infection, and responsiveness to antileishmanial chemotherapy were intact. By itself, interleukin-13 does not appear to materially influence acquired resistance in this intracellular infection.
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. hwmurray@med.cornell.edu
Henry W
HW
Murray
Christine W
CW
Tsai
Jianguo
J
Liu
Xiaojing
X
Ma
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D007113:Immunity, Innate / Q000235:genetics; D018793:Interleukin-13 / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000235:genetics / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
D016207:Cytokines; D018793:Interleukin-13