[Nonalcoholic steatohepatitis: a clinicopathological analysis of liver biopsy in 32 cases].
OBJECTIVE
To investigate the clinicopathological features of nonalcoholic steatohepatitis (NASH) and elucidate its diagnosis and differential diagnosis.


METHODS
Liver biopsy tissues and clinical data of 32 patients with NASH were collected and the clinicopathological findings by HE and Masson staining were evaluated for NASH grading.


RESULTS
Ballooning degeneration of the liver cells and fibrosis around hepatic sinusoid was scarce in mild NASH cases and increased in moderate to severe cases. Steatotic and inflammatory cells in the liver lobes decrease in liver cirrhosis related to seatohepatitis.


CONCLUSIONS
Ballooning degeneration of the liver cells and fibrosis around the hepatic sinusoid have important value in differential diagnosis of mild from moderate to severe NASH, and correct histological grading benefits clinical intervention and prognostic evaluation of NASH.
Department of Pathology, 175 Hospital of PLA, Zhangzhou 363000, China. Mengjiarong@sina.com
Jia-rong
JR
Meng
Rui-dan
RD
Zheng
Ming-feng
MF
Zhang
Yi-he
YH
Guo
Ming-zhu
MZ
Lin
Tai-jian
TJ
Dai
D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis