[Clinical features and treatment of hepatic tumor-like lesions].
OBJECTIVE
Focal nodular hyperplasia (FNH), inflammatory pseudotumor (IPT), adenomatous nodular hyperplasia (ANH), and focal fatty change (FFC) are common hepatic tumor-like lesions, a group of benign liver diseases, which remains difficult to be distinguished from primary liver cancer (PLC). This study was to investigate the clinical features and treatment of these 4 kinds of hepatic tumor-like lesions.


METHODS
Clinical data of 70 patients with pathologically conformed hepatic tumor-like lesions, treated in Cancer Center of Sun Yat-sen University from 1992 to 2004, were studied retrospectively.


RESULTS
Of the 70 patients, 34 (48.6%) had clinical symptoms, and most of them suffered mild pain in the abdomen; 22 (31.4%) were positive for hepatitis B virus (HBV) antigen; 21 had mild abnormal liver function; 6 had alpha fetal protein (AFP) > 25 microg/L. The ultrasonography and computed tomography (CT) presentations of the tumor-like lesions were various. Only 8 cases of FNH were diagnosed preoperatively. Sixty-one patients received resection, with no postoperative complication occurred. One case of FNH and 1 case of IPT were recurred during follow-up, and treated with non-resection therapy.


CONCLUSIONS
Hepatic tumor-like lesions are difficult to be distinguished from PLC. Exploratory operation should be performed in cases suspicious of PLC.
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China. rpguo@gzsums.edu.cn
Rong-Ping
RP
Guo
Chong
C
Zhong
Ming
M
Shi
Wei
W
Wei
Ya-Qi
YQ
Zhang
Jin-Qing
JQ
Li
Guo-Hui
GH
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005234:Fatty Liver / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D020518:Focal Nodular Hyperplasia; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D006498:Hepatectomy / Q000379:methods*; D006511:Hepatitis B Antigens / Q000097:blood; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000378:metabolism
D006511:Hepatitis B Antigens; D000509:alpha-Fetoproteins