One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
Department of Organic Chemistry, Chemical Diversity Research Institute, 114401 Khimki, Moscow Reg., Russia.
Alexey P
AP
Ilyn
Marina V
MV
Loseva
Vladimir Y
VY
Vvedensky
Elena B
EB
Putsykina
Sergey E
SE
Tkachenko
Dmitri V
DV
Kravchenko
Alexandr V
AV
Khvat
Mikhail Y
MY
Krasavin
Alexandre V
AV
Ivachtchenko
D002219:Carbamates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry
D002219:Carbamates; D013841:Thiazepines; C070766:carbamic acid