[Factor V Leiden (G1691A) and prothrombin-G20210A alleles among patients with deep venous thrombosis and in the general population from Spain].
BACKGROUND
Factor V leiden and the -G20210A variant of prothrombin gene are associated to a higher risk of deep venous thrombosis.


OBJECTIVE
To assess the frequency of factor V Leiden (G1691A) and prothrombin -G20210A alleles in patients with deep venous thrombosis (DVT) and in the general population from Spain.


METHODS
Factor V Leiden (g1691a) and prothrombin-g20210a alleles were genotyped in 493 individuals from the Spanish general populations and in 131 patients with DVT. The presence of DVT was confirmed by phlebography. Allelic frequencies and the DVT risk associated with these variants were estimated.


RESULTS
Allelic frequencies for the factor V Leiden (G1691A) allele were 0.019 in patients with DVT and 0.010 in the general population (p=0.235). The frequencies for the prothrombin-G20210A allele were 0.027 and 0.026 (p=0.975). After adjustment for age and gender, the odds ratio for DVT, associated with the presence of G1691A allele was 2.41, but not statistically significant (95% confidence intervals 0.63-9.19).


CONCLUSIONS
Prothrombin-G20210A allele was more prevelant than factor V Leiden (G1691A) allele in the Spanish population. However, the magnitude of the association between the G20210A and DVT risk is very low. On the contrary, the G1691A allele is associated by itself with a two fold increase in DVT risk in this population although without reaching statistical significance due to its low frequency.
Unidad de Epidemiología Genética y Molecular, Departament de Medicina Preventiva, Universitat de València, España. francesc.frances@uv.es
Francesc
F
Francès
Olga
O
Portolès
Francisco
F
Gabriel
Dolores
D
Corella
José Vicente
JV
Sorlí
Antonio
A
Sabater
José L
JL
Alfonso
Marisa
M
Guillén
D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D013030:Spain; D020246:Venous Thrombosis / Q000235:genetics*
D005819:Genetic Markers; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin