The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.
Low levels of Nrf2 activity predispose cells to chemical carcinogenesis. Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer.
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.
John D
JD
Hayes
Michael
M
McMahon
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D003598:Cytoskeletal Proteins / Q000235:genetics; D019143:Evolution, Molecular; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D000072019:Kelch-Like ECH-Associated Protein 1; D051379:Mice; D008954:Models, Biological; D051267:NF-E2-Related Factor 2 / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics*; D010084:Oxidation-Reduction; D011506:Proteins / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002273:Carcinogens; D003598:Cytoskeletal Proteins; D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; C117301:Keap1 protein, mouse; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D011506:Proteins; D017382:Reactive Oxygen Species