Genetics of type 2 diabetes.
After several years of uncertain progress, the stage is now set for a transformation in understanding the genetic landscape of type 2 diabetes. Advances in genome informatics, genotyping technology, and statistical methodology, allied to availability of large-scale clinical material, are having a salutary effect on susceptibility gene discovery. The advent of genuinely genome-wide association scans and the prospects for combining genetics with high-throughput genomics are additional sources of optimism for the future.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital Campus, Old Road, Oxford OX3 7LJ, UK. mark.mccarthy@drl.ox.ac.uk
Mark I
MI
McCarthy
Eleftheria
E
Zeggini
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D036281:Genetic Research; D006801:Humans; D047495:PPAR gamma / Q000235:genetics; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D011506:Proteins / Q000235:genetics; D012107:Research Design; D000099161:Kcnj11 Channel
D047495:PPAR gamma; D024661:Potassium Channels, Inwardly Rectifying; D011506:Proteins; D000099161:Kcnj11 Channel