Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis.
We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.
Decramer
Stephane
S
Inserm, U388, 1 Avenue Jean Poulhes, F-31432 Toulouse, France.
Wittke
Stefan
S
Mischak
Harald
H
Zürbig
Petra
P
Walden
Michael
M
Bouissou
François
F
Bascands
Jean-Loup
JL
Schanstra
Joost P
JP
D015415:Biomarkers / Q000652:urine*; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007682:Kidney Pelvis / Q000473:pathology*; D008297:Male; D013058:Mass Spectrometry; D011379:Prognosis; D011446:Prospective Studies; D020543:Proteome / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013048:Specimen Handling; D013997:Time Factors; D014517:Ureteral Obstruction / Q000151:congenital* / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers; D020543:Proteome