[Antiviral defense by APOBEC3 family proteins].
APOBEC3G is a potent antiretroviral factor, which belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand viral DNA. HIV-1 Vif protein overcomes the antiviral activity of APOBEC3G by targeting it for ubiquitin-dependent degradation. Recent accumulating evidences that other members of APOBEC proteins also show antiviral activity on a wide variety of viruses suggest that APOBEC family proteins play a crucial role in an antiviral defense as an innate immunity. Here, we review recent progress in research on APOBEC3 proteins.
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan. atakaori@kuhp.kyoto-u.ac.jp
Akifumi
A
Takaori
D000071478:APOBEC Deaminases; D000818:Animals; D019380:Anti-HIV Agents; D003564:Cytidine Deaminase / Q000502:physiology; D043525:Cytosine Deaminase / Q000502:physiology; D004279:DNA, Viral / Q000235:genetics; D016346:Gene Products, vif / Q000502:physiology; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D005810:Multigene Family; D054320:vif Gene Products, Human Immunodeficiency Virus
D019380:Anti-HIV Agents; D004279:DNA, Viral; D016346:Gene Products, vif; D054320:vif Gene Products, Human Immunodeficiency Virus; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase