The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen.
The influence of BK-viruria, donor background, and conditioning on the development of hemorrhagic cystitis was examined in 90 allogeneic hematopoetic stem cell transplant patients, of whom 15 developed hemorrhagic cystitis. Thirty-two patients had related and 58 had unrelated donors, while 44 received full, and 46 received reduced intensity conditioning (RIC). BK-viruria was more common in patients with hemorrhagic cystitis than in those without (p<0.01), and hemorrhagic cystitis was less common in patients with related donors than in those with unrelated donors (p=0.02). Finally, hemorrhagic cystitis and BK-viruria were less common in patients receiving RIC, rather than full conditioning (p<0.01 and p<0.01, respectively).
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Géraldine
G
Giraud
Gordana
G
Bogdanovic
Peter
P
Priftakis
Mats
M
Remberger
Britt-Marie
BM
Svahn
Lisbeth
L
Barkholt
Olle
O
Ringden
Jacek
J
Winiarski
Per
P
Ljungman
Tina
T
Dalianis
D000293:Adolescent; D000328:Adult; D001739:BK Virus; D002648:Child; D003556:Cystitis / Q000453:epidemiology* / Q000652:urine / Q000821:virology*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006470:Hemorrhage / Q000453:epidemiology* / Q000652:urine / Q000821:virology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000601:surgery / Q000652:urine; D019172:Transplantation Conditioning / Q000009:adverse effects; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000601:surgery / Q000652:urine; D014556:Urine / Q000821:virology*