Relevance of correction for rotational targeting error in functional neurosurgery.
OBJECTIVE
A prospective study is presented on the amount of targeting error that is due to rotational deviations between the atlas and the stereotactic coordinate system.


METHODS
We investigated 14 volunteers with a stereotactic frame fixed to their heads by tight adhesive bands. Sagittal, coronal and axial T2-weighted MRI scans, as well as MPRage sequences, were performed. The anterior and posterior commissures and one additional point on the midline (the septum pellucidum) were determined on the axial T2-weighted images. Bilateral atlas coordinates for the subthalamic nucleus (STN), globus pallidus pars interna (GPi) and nucleus ventralis intermedius (Vim) were transformed to stereotactic frame coordinates, either without correction or by 2-point or 3-point correction. A total of 896 coordinates (x, y, z for the STN, GPi and Vim in both hemispheres) were calculated.


RESULTS
Although the mean differences between the two algorithms (0.24 +/- standard deviation of 0.33 mm) were within the range of system-immanent inaccuracies in MRI-guided stereotaxy, deviations of up to 2.8 mm occurred. No significant correlation was found regarding the amount of rotational angle and the differences in x-, y-, or z-coordinates when 2-point and 3-point transformations were compared.


CONCLUSIONS
The reliability of meticulous trajectory planning might be compromised significantly by using only 2-point-based correction or no calculations at all.
Department of Neurosurgery, University of Regensburg, Regensburg, Germany. juergen.schlaier@klinik.uni-regensburg.de
Juergen
J
Schlaier
Peter
P
Herzog
Petra
P
Schoedel
Hans
H
Aldebert
Max
M
Lange
Christian
C
Doenitz
Juergen
J
Winkler
Jan
J
Warnat
Thomas
T
Finkenzeller
Alexander
A
Brawanski
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D013238:Stereotaxic Techniques