[Treatment of gastrointestinal stromal tumor (GIST)--review of the literature and a case report].
BACKGROUND
Gastrointestinal stromal tumors (GIST) are rare mesenchimal tumors that are characterized by constitutive overexpression of the tyrosin-kinase receptor KIT (CD117). The authors analyse the basis of the treatment of gastric GIS, starting form the study of a recent observed case.


METHODS
Report of one case treated with endoscopic resection. Evaluation of treatment and 2-years follow-up.


RESULTS
The treatment of gastric GIST must be modulated on prognostic, genetic and molecular factors. These factors are the basis of the formation and growth of GIST.


CONCLUSIONS
Complete surgical extirpation without rupture remains the only curative treatment of localized favourable prognosis. Endoscopic treatment, as in our case, reflect the modulation of therapy on prognostic factors. Selective targeted therapy of metastatic disease yields encouraging clinical responses.
Geraci
Girolamo
G
Azienda Ospedaliera Universitaria, Policlinico "P. Giaccone", Dipartimento di Chirurgia Generale d'Urgenza e dei Trapianti d'Organo, Sezione di Chirurgia Generale ad Indirizzo Toracico. girgera@tin.it
Li Volsi
Francesco
F
Pisello
Franco
F
Sciumè
Carmelo
C
Cajozzo
Massimo
M
Cavaleri
Calogero
C
Modica
Giuseppe
G
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate