Passive protection of dogs against clinical disease due to Canine parvovirus-2 by specific antibody from chicken egg yolk.
The protective effect of immunoglobulins derived from chicken egg yolk (IgY) against infection by Canine parvovirus 2 (CPV-2) was evaluated in 10 beagle dogs orally challenged with a strain of the virus. The 2-mo-old dogs were divided into 3 groups and treated with powders containing CPV-2 IgY or normal egg yolk for 7 d after the challenge. The 4 dogs receiving normal egg yolk (control group) demonstrated mild symptoms typical of CPV-2 infection, such as vomiting, diarrhea, and weight loss. No symptoms were observed by 16 d after challenge in the 3 dogs receiving 2 g of IgY powder. Of the 3 dogs receiving 0.5 g of IgY powder, 2 had clinical CPV-2 disease; however, the manifestations were less severe than in the control group. Furthermore, the IgY-treated groups had significantly greater weight gain and shorter duration of virus shedding than the control group. These results indicate that IgY is useful in protecting dogs from CPV-2-induced clinical disease.
Van Nguyen
Sa
S
Immunology Research Institute, GHEN Corporation, 839-1 Sano, Gifu City, 501-1101, Japan. nguyen@ghen.co.jp
Umeda
Kouji
K
Yokoyama
Hideaki
H
Tohya
Yukinobu
Y
Kodama
Yoshikatsu
Y
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D002645:Chickens; D004283:Dog Diseases / Q000517:prevention & control* / Q000821:virology; D004285:Dogs; D004530:Egg Yolk; D007116:Immunization, Passive / Q000379:methods / Q000662:veterinary*; D009500:Neutralization Tests / Q000662:veterinary; D010322:Parvoviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000276:immunology*; D017201:Virus Shedding; D015430:Weight Gain
D000914:Antibodies, Viral