Resveratrol, a red wine constituent polyphenol, protects gastric tissue against the oxidative stress in cholestatic rats.
This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis.
Department of General Surgery, Inonu University School of Medicine, 44069 Malatya, Turkey.
Vedat
V
Kirimlioglu
Cengiz
C
Ara
Mehmet
M
Yilmaz
Dincer
D
Ozgor
Burak
B
Isik
Gokhan
G
Sogutlu
Hale
H
Kirimlioglu
Aysun Bay
AB
Karabulut
Sezai
S
Yilmaz
Cuneyt
C
Kayaalp
Saim
S
Yologlu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001652:Bile Ducts / Q000601:surgery; D002779:Cholestasis / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D008026:Ligation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
D000975:Antioxidants; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione; D000077185:Resveratrol