ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra.
A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non-linear outer loop and an inner linear least-squares fit for the concentrations. In vitro and in vivo experiments on a whole-body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetylaspartate, N-acetylaspartylglutamate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, gamma-aminobutyric acid, alanine and ascorbic acid.
Institute for Biomedical Engineering, University and ETH Zurich, CH-8092 Zurich, Switzerland.
Rolf F
RF
Schulte
Peter
P
Boesiger
D000328:Adult; D000465:Algorithms; D003401:Creatine / Q000378:metabolism*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods; D014018:Tissue Distribution
D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D003401:Creatine