High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries.
We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.
Faivre
Laurence
L
Centre de Génétique Médicale, Hôpital d'Enfants, Dijon, France. laurence.faivre@chu-dijon.fr
Meerpohl
Jörg
J
Da Costa
Lydie
L
Marie
Isabelle
I
Nouvel
Christian
C
Gnekow
Astrid
A
Bender-Götze
Christine
C
Bauters
Francis
F
Coiffier
Bertand
B
Peaud
Pierre-Yves
PY
Rispal
Patrick
P
Berrebi
Alain
A
Berger
Claire
C
Flesch
Michel
M
Sagot
Paul
P
Varet
Bruno
B
Niemeyer
Charlotte
C
Tchernia
Gil
G
Leblanc
Thierry
T
D000740:Anemia / Q000517:prevention & control; D029503:Anemia, Diamond-Blackfan / Q000150:complications* / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D003625:Data Collection; D005260:Female; D005602:France; D005858:Germany; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000209:etiology; D012042:Registries; D012189:Retrospective Studies
D001241:Aspirin