Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males.
OBJECTIVE
To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender.


METHODS
tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls.


RESULTS
Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05).


CONCLUSIONS
Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies.
Division of Radiology, Department of Medicine and Care, Faculty of Health Sciences, Linköping University, Sweden.
J Patrik
JP
Fägerstam
Per A
PA
Whiss
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001792:Blood Platelets / Q000737:chemistry*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D003424:Crohn Disease / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D012307:Risk Factors; D012727:Sex Characteristics; D013923:Thromboembolism / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019007:P-Selectin; D019804:Mesalamine