Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease correlate with major autonomic symptoms?
OBJECTIVE
To compare MIBG (metaiodobenzylguanidine) uptake between Parkinson's disease patients with and without autonomic symptoms to investigate meanings of MIBG scintigraphy and correlations between autonomic symptoms and MIBG uptake.


METHODS
Forty consecutive patients with Hoehn-Yahr III or IV Parkinson's disease and 12 controls were enrolled. We compared cardiac MIBG uptake between patients with and without orthostatic hypotension. Similar comparisons were performed for constipation and bladder dysfunction.


RESULTS
MIBG uptake did not significantly correlate with age, disease duration, Hoehn-Yahr stage, Unified Parkinson's Disease Rating Scale (UPDRS) motor score or levodopa equivalent daily doses. There were no significant correlations between orthostatic hypotension/constipation and cardiac MIBG uptake. Only bladder symptoms significantly correlated with MIBG uptake.


CONCLUSIONS
Meanings of MIBG uptake abnormalities in Parkinson's disease and relationship between MIBG uptake and clinical parameters remain to be resolved in future studies.
Matsui
Hideaki
H
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka 530-0005, Japan. matsui-hideaki@sumitomo-hp.or.jp
Nishinaka
Kazuto
K
Oda
Masaya
M
Komatsu
Kenichi
K
Kubori
Tamotsu
T
Udaka
Fukashi
F
D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D003248:Constipation / Q000150:complications; D003627:Data Interpretation, Statistical; D004185:Disability Evaluation; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D001745:Urinary Bladder Diseases / Q000150:complications / Q000503:physiopathology
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine