The influence of downstream arterial perfusion parameters on doppler pulsatility index and resistance index in an in-vitro perfusion model.
BACKGROUND
To investigate in vitro how downstream perfusion parameters influence pulsatility index (PI), resistance index (RI) and their constituting Doppler velocities.


METHODS
We analyzed the influence of resistance, compliance, reflection coefficient and input impedance on PI and RI in an in-vitro model of arterial flow.


RESULTS
The nominators of PI and RI were determined by resistance. The numerators were determined by compliance and by the reflection coefficient. There were close relationships of PI and RI with resistance under the condition of constant compliance, but not when compliance was variable.


CONCLUSIONS
PI and RI consist of velocity terms which are independently influenced by different parameters of impedance: compliance, reflection coefficient and resistance. These findings explain the contradictory results reported for the relationship between the indices and peripheral resistance in studies where compliance and reflection effects were not considered.
Department of Angiology, Universitäts-Gefässzentrum Carl Gustav Carus, TU Dresden, Germany. benj.schmidt@gmx.de
B
B
Schmidt
D
D
Ockert
A
A
Deussen
S
S
Schellong
D000818:Animals; D001158:Arteries / Q000502:physiology*; D001783:Blood Flow Velocity; D003187:Compliance; D006801:Humans; D066298:In Vitro Techniques; D017078:Laser-Doppler Flowmetry; D008955:Models, Cardiovascular; D011674:Pulse; D014655:Vascular Resistance