A new type of steroids with a cyclobutane fragment in the AB-ring moiety.
The synthesis of a 5,10-seco steroid containing two double bonds in a AB-macrocycle as well as the preparation of a steroidal skeleton with a cyclobutane fragment is described. The structures of these compounds are different from those of natural steroids, but they are very similar with respect to conformation of the carbon skeleton.
Khripach
Vladimir A
VA
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str., 5/2, 220141 Minsk, Belarus, The Netherlands. khripach@iboch.bas-net.by
Zhabinskii
Vladimir N
VN
Fando
Galina P
GP
Kuchto
Anna I
AI
Khripach
Natalya B
NB
Groen
Marinus B
MB
van der Louw
Jaap
J
de Groot
Aede
A
D003503:Cyclobutanes / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry; D012632:Secosteroids / Q000138:chemical synthesis / Q000737:chemistry; D013256:Steroids / Q000737:chemistry*; D013329:Structure-Activity Relationship
D003503:Cyclobutanes; D012632:Secosteroids; D013256:Steroids; D010126:Ozone