Novel cisplatin-type platinum complexes and their cytotoxic activity.
A series of novel cisplatin-type platinum complexes, formulated as [PtA2(OCOCH2OR)2] (A2 = two monoamines or one diamine, R is an alkyl group), were designed, characteristic of alkoxyacetate as carboxylato ligands. The pertinent compounds were prepared and characterized by elementary analyses, IR, 1H NMR, and ESI-MS spectra. The cytotoxic activities of compound 1a in vitro toward HL-60 human leukemia and BEL-7402 human hepatocellular carcinoma cell lines were pioneeringly studied. Then, compounds 1b-3d were evaluated for their in vitro cytotoxicity against Ramos human lymphoma, 3AO human ovarian carcinoma, and A549 human non-small cell lung cancer cell lines. Most of them showed better cytotoxic activity than carboplatin against above selected cell lines.
Cui
Kai
K
State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China.
Wang
Lianhong
L
Zhu
Haibin
H
Gou
Shaohua
S
Liu
Yun
Y
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000633:toxicity*; D006801:Humans; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*
D010984:Platinum; D002945:Cisplatin