Rewiring phagocytic signal transduction.
In this issue of Immunity, primary macrophages from Vav1(-/-)/Vav3(-/-) and Rac1(-/-)/Rac2(-/-) mice to produce a new picture of Fcgamma receptor and complement receptor 3 intracellular signaling have been examined.
Lowell
Clifford A
CA
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
D000818:Animals; D016177:Macrophage-1 Antigen / Q000502:physiology*; D051379:Mice; D010587:Phagocytosis; D051567:Proto-Oncogene Proteins c-vav / Q000502:physiology*; D017452:Receptors, IgG / Q000502:physiology; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D016177:Macrophage-1 Antigen; D051567:Proto-Oncogene Proteins c-vav; D017452:Receptors, IgG; D020741:rho GTP-Binding Proteins