Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma.
Radiation therapy is often used to achieve local control of pelvic Ewing sarcoma in children. The effects of radiation on the female reproductive tract have been well documented in adults with gynecological malignancies, but the long-term consequences of pelvic radiation in pre-pubertal or adolescent girls are not as well described. We report a case of hematometrocolpos developing in an adolescent previously treated with chemotherapy and radiation therapy for pelvic Ewing sarcoma. We describe the clinical presentation, radiographic features, gross pathology, treatment strategies, outcome, as well as putative predisposing factors and preventative interventions.
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pamela
P
Gaillard
Matthew J
MJ
Krasin
Fred H
FH
Laningham
Fredric A
FA
Hoffer
Andrew M
AM
Davidoff
Sheri L
SL
Spunt
Linda
L
Smiley
Stephen X
SX
Skapek
D001859:Bone Neoplasms / Q000628:therapy*; D002648:Child; D005260:Female; D006399:Hematocolpos / Q000209:etiology*; D006409:Hematometra / Q000209:etiology*; D006801:Humans; D010384:Pelvic Bones; D010386:Pelvic Neoplasms / Q000628:therapy; D012512:Sarcoma, Ewing / Q000628:therapy*