Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners.
Frequent tanning has reinforcing properties. We tested whether opioid antagonism blocks potential reinforcing effect of indoor tanning in 8 frequent tanners and 8 infrequent tanner control subjects. Opioid blockade reduced ultraviolet preference in frequent tanners. Four of 8 frequent tanners, but no infrequent tanners, exhibited withdrawal-like symptoms with naltrexone administration. A limitation of this study is its small size.
Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.
Mandeep
M
Kaur
Anthony
A
Liguori
Wei
W
Lang
Stephen R
SR
Rapp
Alan B
AB
Fleischer
Steven R
SR
Feldman
D000293:Adolescent; D000328:Adult; D001505:Beauty Culture; D016739:Behavior, Addictive / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D009271:Naltrexone / Q000009:adverse effects / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D012867:Skin / Q000528:radiation effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D014466:Ultraviolet Rays
D009292:Narcotic Antagonists; D009271:Naltrexone