Minor alkaloids from Guatteria dumetorum with antileishmanial activity.
Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine ( 3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1-4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.
Laboratorio de Bioorgánica Tropical, Universidad de Panamá, República de Panamá.
Jhonny Edmith
JE
Correa
Carlos Hernán
CH
Ríos
Amparo
A
del Rosario Castillo
Luz I
LI
Romero
Eduardo
E
Ortega-Barría
Phyllis D
PD
Coley
Thomas A
TA
Kursar
Maria Verónica
MV
Heller
William H
WH
Gerwick
Luis Cubilla
LC
Rios
D000818:Animals; D002522:Chlorocebus aethiops; D031043:Guatteria; D006801:Humans; D007894:Leishmania mexicana / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells / Q000187:drug effects
D010936:Plant Extracts; D014344:Trypanocidal Agents