Pilot-scale production of group a and group C meningococcal polysaccharide immunogens.
Methods have been developed for the pilot-scale production of group A and group C meningococcal polysaccharide immunogens based on the meningococcal strains, the medium, and the basic processing procedures used by Gotschlich et al. Physical and chemical assays on the final products obtained on a pilot-scale level indicate that these purified polysaccharides are entirely comparable to the Gotschlich preparations which proved to be immunogenic in man.
Department of Biologics Research, Walter Reed Army Institute of Research, Washington, D.C. 20012.
S
S
Berman
P L
PL
Altieri
A
A
Groffinger
J P
JP
Lowenthal