[Adipose tissue: a new endocrine organ].
In the recent years we have begun to appreciate that adipose tissue is more than just a passive repository for excess energy. It is a highly active endocrine organ secreting a range of bioactive peptides with both local and distant action collectively called 'adipokines' or 'adipose tissue hormones'. They include leptin, adiponectin, resistin, acylation-stimulating protein (ASP), plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor alpha (TNFalpha), interleukin 6, and angiotensinogen. Some of these are specific fat-related hormones that are involved in regulating energy homeostasis, carbohydrate and lipid metabolism, vascular homeostasis and immune response. Moreover, the tissue is implicated in the metabolism of some steroid hormones. Disturbances in adipokine production may have potential repercussions in the pathophysiology of obesity, insulin resistance, and dyslipidemia. Reversal or alleviation of these changes seem to be a promising target for management of the mentioned disorders. The objective of this review is to summarise the most important aspects of biology, actions and regulation of these hormones with a special emphasis on the most recent literature.
Katedra Farmakologii, Zakład Farmakologii, Klinicznej Slaskiej Akademii Medycznej, Katowice. r.krysiak@pharmanet.com.pl
Robert
R
Krysiak
Bogusław
B
Okopień
Zbigniew Stanisław
ZS
Herman
D000215:Acylation; D000217:Acyltransferases / Q000502:physiology; D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000378:metabolism; D000808:Angiotensinogen / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D020738:Leptin / Q000378:metabolism; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology; D052243:Resistin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D052242:Adiponectin; D015850:Interleukin-6; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D000808:Angiotensinogen; D000217:Acyltransferases; D006854:Hydrocortisone