Recurrent Salmonella bacteremia in interleukin-12 receptor beta1 deficiency.
Interleukin-12 receptor beta1 IL12RB1 deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.
Inonu University, Faculty of Medicine, Division of Pediatric Infectious Disease, Malatya, Turkey. metehanoz@yahoo.com
Metehan
M
Ozen
Mehmet
M
Ceyhan
Ozden
O
Sanal
Mehmet
M
Bayraktar
Lütfiye
L
Mesci
D016470:Bacteremia / Q000378:metabolism / Q000382:microbiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D018123:Receptors, Interleukin / Q000172:deficiency* / Q000235:genetics; D053707:Receptors, Interleukin-12; D012475:Salmonella / Q000302:isolation & purification*; D012480:Salmonella Infections / Q000235:genetics / Q000378:metabolism*
C508438:IL12RB1 protein, human; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12