[Acidic fibroblast growth factor for preventing motor endplate degeneration and muscular atrophy after motor nerve injury: a morphological and electrophysiological study].
OBJECTIVE
To explore measures to prevent motor endplate degeneration and muscular atrophy after motor nerve injury.


METHODS
Thirty Sprague-Dawley rats were randomized into 3 equal groups. In two of the groups, the right common peroneal nerves of the rats were transected and immediately sutured with implantation of collagen gel carrier of acidic fibroblast growth factor (aFGF) or the empty carrier into the denervated tibialis anterior muscles. In the control group, the transected nerves were sutured without implantation. Six weeks after the operation, morphological and electrophysiological examinations were performed.


RESULTS
In the control rats and those with empty collagen gel carrier implantation, obvious motor endplate degeneration and muscular atrophy occurred, which were not obvious in rats receiving aFGF carrier implantation. The decrement of repetitive nerve stimulation was significantly greater in the former two groups than in the latter.


CONCLUSIONS
Implantation of collagen gel carrier of aFGF may prevent motor endplate degeneration and facilitate functional recovery of the neuromuscular junction after motor nerve injury.
Yang
Shao-an
SA
Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. yangshaoan@hotmail.com
Jin
An-min
AM
Zou
Xiao-ying
XY
Xiao
Xiao-tao
XT
Xiao
Sha
S
D000818:Animals; D004594:Electrophysiology; D005260:Female; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009045:Motor Endplate / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D009121:Muscle Denervation / Q000379:methods; D009133:Muscular Atrophy / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control*; D009416:Nerve Regeneration / Q000187:drug effects; D010543:Peroneal Nerve / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D016220:Fibroblast Growth Factor 1