Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agriculture.
Bovine tuberculosis (bTB) is an important disease of cattle and an emerging infectious disease of humans. Cow- and badger-based control strategies have failed to eradicate bTB from the British cattle herd, and the incidence is rising by about 18%per year. The annual cost to taxpayers in Britain is currently 74 million UK pounds. Research has focused on the badger as a potential bTB reservoir, with little attention being paid to other mammals common on farmland. We have conducted a systematic survey of wild mammals (n=4393 individuals) present on dairy farms to explore the role of species other than badgers in the epidemiology of bTB. Cultures were prepared from 10397 samples (primarily faeces, urine and tracheal aspirates). One of the 1307 bank voles (Clethrionomys glareolus) live-sampled, and three of the 43 badgers (Meles meles), yielded positive isolates of Mycobacterium bovis. This is the first time the bacterium has been isolated from the bank vole. The strain type was the same as that found in cattle and badgers on the same farm. However, our work indicates that the mean prevalence of infectious individuals among common farmland wildlife is extremely low (the upper 95% confidence interval is < or =2.0 for all of the abundant species). Mathematical models illustrate that it is highly unlikely the disease could be maintained at such low levels. Our results suggest that these animals are relatively unimportant as reservoirs of bTB, having insufficient within-species (or within-group) transmission to sustain the infection, though occasional spill-overs from cattle or badgers may occur.
Mathews
Fiona
F
Wildlife Conservation Research Unit, Department of Zoology, University of Oxford, Tubney House, Abingdon Road, Tubney, Oxon OX13 5QL, UK. fiona.mathews@zoo.ox.ac.uk
Macdonald
David W
DW
Taylor
G Michael
GM
Gelling
Merryl
M
Norman
Rachel A
RA
Honess
Paul E
PE
Foster
Rebecca
R
Gower
Charlotte M
CM
Varley
Susan
S
Harris
Audrey
A
Palmer
Simonette
S
Hewinson
Glyn
G
Webster
Joanne P
JP
D000818:Animals; D000835:Animals, Wild / Q000382:microbiology*; D002417:Cattle; D003430:Cross-Sectional Studies; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary*; D005838:Genotype; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000254:growth & development*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence; D014380:Tuberculosis, Bovine / Q000453:epidemiology* / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology
D004269:DNA, Bacterial