[Rh hemolytic disease in a pregnant woman after peripheral blood progenitor cells allotransplantation mismatched in Rh and ABO group system -- case report].
This is a case of a patient, who had peripheral blood progenitor cells transplantation as treatment for aplastic anaemia and changed her blood group phenotype from Rh plus to Rh minus. When she became pregnant, she produced very early anti-Rh-D antibodies. These antibodies were directed against erythrocytes of the foetus who inherited Rh-D antigen after his mother (father was Rh minus). During this pregnancy we observed a mild example of Rh-disease, which required fetal blood testing, without the necessity of intrauterine blood transfusion. We can assume, that the immunization with Rh-D antigen had taken place before pregnancy, probably during the blood group conversion after the transplantation. We think, that blood progenitor cells transplantation, different in groups of blood may exemplify a new source of immunization and development of serological conflict in pregnancy. In cases of pregnancies, in which the child's mother or father is after grafting of blood progenitor cells, when analyzing the blood group of the foetus we should know the blood groups of parents before transplantation.
Klinika Ginekologii i Połoznictwa, CMKP, SPSK nr 1, ul. Czerniakowska 231, 00-416 Warszawa, Poland.
Marzena
M
Samsel
Romuald
R
Debski
Mariola
M
Sedzimirska
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D001787:Blood Group Incompatibility / Q000276:immunology*; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000175:diagnosis; D005260:Female; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000628:therapy; D011256:Pregnancy Outcome; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000276:immunology*; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System