Tritiation of imipramine and pseudo irreversible analogues 3-cyanoimipramine and 2-nitroimipramine at high specific activity.
Methods are presented to synthesize and characterize [N-methyl-3H] imipramine 3, [N-methyl-3H] 3-cyanoimipramine 6 and [N-methyl-3H] 2-nitroimipramine 9.
PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
David G
DG
Ahern
Eileen
E
Johnson
Anne G
AG
Laseter
Crist N
CN
Filer
D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000737:chemistry; D007099:Imipramine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D014316:Tritium / Q000737:chemistry*
D000929:Antidepressive Agents, Tricyclic; D019275:Radiopharmaceuticals; C024316:cianopramine; D014316:Tritium; C065353:N-methylimipramine; C030721:2-nitroimipramine; D007099:Imipramine