[Influence of Helicobacter pylori infection on the results of 24-hour gastric pH-metry in patients diagnosed because of atypical chest pain].
Changes in gastric acidity induced by Helicobacter pylori (Hp) infection, may influence intensity of symptoms in patients diagnosed because of chest pain. The aim of this study was to compare the results of 24-hours gastric pH-metry in patients suffering from atypical chest pain infected and not-infected by Hp.


METHODS
In 99 men diagnosed because of atypical chest pain performed were: interview, physical examination, gastroduodenoscopy with musoca biopsy from gastric corpus and antrum, as well as 24-hour gastric pH-metry. Hp infection was diagnosed on the basis of positive urease test or/and histologic examination.


RESULTS
78% of subjects were infected by Hp. Hp positive patients had lower total and night-time percentage of monitoring time with gastric pH<4 and greater with pH > 6. Patients with isolated antral Hp colonization and subjects with pangastritis didn't differ in respect to gastric pH-metry parameters values. However in patients, with Hp colonization only in gastric corpus the time with gastric pH < 4 was shorter and with pH > 6 longer than in other groups.


CONCLUSIONS
Hp-positive patients with atypical chest pain had lower gastric acidity than Hp-negative subjects. In patients with corporal Hp gastric mucosa colonization higher intra-gastric pH was observed than in the rest of patients.
Kłopocka
Maria
M
Katedra i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych, Akademii Medycznej im. L Rydygiera w Bydgoszczy. mariaklopocka@wp.pl
Budzyński
Jacek
J
Wiatkowski
Maciej
M
Korenkiewicz
Lukasz
L
Pulkowski
Grzegorz
G
Grad
Krzysztof
K
D000328:Adult; D001706:Biopsy; D002637:Chest Pain / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D005744:Gastric Acid / Q000737:chemistry*; D005756:Gastritis / Q000150:complications / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000473:pathology; D013997:Time Factors