Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.
Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
MicroCHIPS Inc., 6-B Preston Court, Bedford, Massachusetts 01730, USA.
James H
JH
Prescott
Sara
S
Lipka
Samuel
S
Baldwin
Norman F
NF
Sheppard
John M
JM
Maloney
Jonathan
J
Coppeta
Barry
B
Yomtov
Mark A
MA
Staples
John T
JT
Santini
D000818:Animals; D004285:Dogs; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015918:Infusion Pumps, Implantable; D016729:Leuprolide / Q000008:administration & dosage*; D008297:Male; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization; D013686:Telemetry / Q000295:instrumentation*
D016729:Leuprolide