Nickel-catalyzed asymmetric alpha-arylation of ketone enolates.
An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.
Chen
Guoshu
G
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong.
Kwong
Fuk Yee
FY
Chan
Hoi On
HO
Yu
Wing-Yiu
WY
Chan
Albert S C
AS
D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism; D044024:Tetralones / Q000737:chemistry*
D007659:Ketones; D044024:Tetralones; D009532:Nickel