Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs.
The purposes of the present study were to investigate the effects of the alpha1-adrenoceptor antagonists tamsulosin, prazosin and urapidil on resting urethral pressure in anaesthetized female dogs, and to compare the results with their effects on arterial blood pressure. Tamsulosin decreased resting maximal urethral pressure in the urethral pressure profile in a dose-dependent fashion, whereas it had almost no effect on mean arterial blood pressure. Prazosin and urapidil also dose-dependently decreased resting maximal urethral pressure, but these effects were accompanied by decreases in mean arterial blood pressure. Thus, of these three compounds, tamsulosin dose-dependently decreased resting maximal urethral pressure with negligible effect on mean arterial blood pressure in female dogs. These results suggest that tamsulosin will be useful in the treatment of voiding dysfunction associated with bladder outlet obstruction in women, with little hypotensive effect.
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. akiyoshi.ohtake@jp.astellas.com
Akiyoshi
A
Ohtake
Shuichi
S
Sato
Masao
M
Sasamata
Keiji
K
Miyata
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology; D011224:Prazosin / Q000009:adverse effects / Q000494:pharmacology; D011312:Pressure; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology*; D000077409:Tamsulosin; D014521:Urethra / Q000187:drug effects* / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D010879:Piperazines; D013449:Sulfonamides; C015568:urapidil; D000077409:Tamsulosin; D011224:Prazosin