[Study on the associations between inflammatory factor and insulin resistance as well as type 2 diabetes with macrovascular complications].
OBJECTIVE
To study the possible association between C-reactive (CRP) and insulin resistance (IR) as well as the pathogenesis of type 2 diabetes macrovascular complication.


METHODS
Serum CRP was measured by ultrasensitive immuoturbidimetric, which was determined on type 2 diabetes (T2DM) with or without macrovascular complication (70 and 60 cases respectively) and on normal controls (90 cases). IR was estimated by homeostasis model assessment (HOMA-IR).


RESULTS
Results showed that the concentration of CRP was higher in T2DM with or without macrovascular complications than that in the healthy subjects (P < 0.01), while it was higher in diabetic patients with macrovascular complications than that in diabetic patients without macrovascular complications (P < 0.01). In diabetic patients with macrovascular complications, person correlation analysis indicated that there existed positive correlations between CRP and FINS, HOMA-IR, triglyceride (TG) while stepwise linear regression showed that usCRP and HOMA-IR, TG having linear correlation.


CONCLUSIONS
CRP seemed to play a role in the initiation and progression of atherosclerosis in type 2 diabetes, possibly was by the way of IR.
Department of Endocrinology, Shaoxing People's Hospital, Shaoxing 312000, China.
Qiao-ying
QY
You
Cheng-jiang
CJ
Li
Hong
H
Li
Qi-qian
QQ
Zhu
Xu-wei
XW
Si
D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006706:Homeostasis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D008875:Middle Aged
D018836:Inflammation Mediators; D006710:Homocysteine; D002097:C-Reactive Protein