Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice.
The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naïve mice. In contrast, in vaccinated mice, the swift CD8+-T-cell response helps host survival after challenge.
CINTERGEN, UNIFESP-Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo-SP, Brazil, 04044-010.
Fanny
F
Tzelepis
Bruna C G
BC
de Alencar
Marcus L O
ML
Penido
Ricardo T
RT
Gazzinelli
Pedro M
PM
Persechini
Mauricio M
MM
Rodrigues
D000818:Animals; D016827:CD8 Antigens / Q000235:genetics; D014355:Chagas Disease / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control; D003601:Cytotoxicity Tests, Immunologic; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009439:Neuraminidase / Q000276:immunology; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D016052:Protozoan Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology* / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000276:immunology*
D016827:CD8 Antigens; C431698:CD8alpha antigen; D018984:Epitopes, T-Lymphocyte; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D016052:Protozoan Vaccines; D054353:Perforin; D007371:Interferon-gamma; C069715:trans-sialidase; D009439:Neuraminidase