Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats.
Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 microg/g dry weight of luteolin and 41 microg/g dry weight of luteolin-6-C-glucoside. It also contained gamma-aminobutyric acid (GABA, 2.4 mg/g dry weight by LC-MS/MS or 4.4 mg/g dry weight by amino acid analysis) which has been reported to be an antihypertensive material. Since the extract contained a relatively high concentration of GABA, the antihypertensive effect of the extract in SHRs might be due mostly to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan. ichimura@ni.aist.go.jp
Toshiaki
T
Ichimura
Akiko
A
Yamanaka
Toshio
T
Ichiba
Tetsuya
T
Toyokawa
Yasuhiro
Y
Kamada
Takako
T
Tamamura
Susumu
S
Maruyama
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002853:Chromatography, Liquid; D006973:Hypertension / Q000188:drug therapy; D029598:Passiflora / Q000737:chemistry*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D010936:Plant Extracts