Migraine patients have lower systolic but higher diastolic blood pressure compared with controls in a population-based study of 21,537 subjects. The Reykjavik Study.
Several studies have explored a possible association between migraine and hypertension, with contradictory results. Because of this uncertainty the relation between blood pressure (BP) and migraine was studied in 10,366 men and 11,171 women in a population-based longitudinal study. A modified version of the 1988 International Headache Society criteria was used for diagnosis of migraine. Logistic regression analysis was used. The crude 1-year prevalence of migraine was 5.2% among men and 14.1% among women. No significant association was found between hypertension and migraine. For a one standard deviation (SD) increase in diastolic BP the probability of having migraine increased 14% (P = 0.11) for men and 30% (P < 0.0001) for women. For a 1-SD increase in systolic BP the probability of having migraine decreased 19% (P = 0.007) for men and 25% (P < 0.0001) for women. It was also found that for a 1-SD increase in pulse pressure the probability of having migraine decreased 13% (P = 0.005) for men and 14% (P < 0.0001) for women. In a population-based study of men and women it was found that subjects with migraine had lower pulse pressure, lower systolic BP and higher diastolic BP compared with controls.
Department of Pharmacology and Toxicology, University of Iceland, Reykjavik, Iceland.
L S
LS
Gudmundsson
G
G
Thorgeirsson
N
N
Sigfusson
H
H
Sigvaldason
M
M
Johannsson
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015897:Comorbidity; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007055:Iceland / Q000453:epidemiology; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013599:Systole