Peroxidative protection of parenteral admixture by D-alpha-tocopherol.
High lipid:low dextrose (HL:LD) parenteral admixtures (PAs) are becoming commonplace in the nutritional support of veterinary patients. Lipid peroxidation before administration appears to be an unwanted sequela of high lipid content in PAs that can lead to oxidative injury of biologic membranes in vivo. The purpose of this in vitro study was to measure hydroperoxides in HL:LD PAs and to determine the optimal dose of d-alpha-tocopherol to minimize peroxidation in these PAs during a 24-hr period. Detectable concentrations of hydroperoxides were present in all PAs. D-alpha-tocopherol appeared to significantly minimize peroxidation of HL:LD PAs in vitro. These results have clinical implications for parenteral feeding in critically ill patients.
Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Duck Pond Drive, Blacksburg, VA, 24061, USA.
Iveta
I
Becvarova
Korinn E
KE
Saker
William S
WS
Swecker
Gregory C
GC
Troy
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005217:Fat Emulsions, Intravenous; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000032:analysis*; D010084:Oxidation-Reduction; D010288:Parenteral Nutrition / Q000379:methods / Q000592:standards / Q000662:veterinary*; D011897:Random Allocation; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D005217:Fat Emulsions, Intravenous; D008054:Lipid Peroxides; D024502:alpha-Tocopherol