Residues of fluoroquinolone drugs in the cloacal gland and other tissues of Japanese quail.
1. In this study we investigated the residues of fluoroquinolone drugs (ciprofloxacin and pefloxacin) in the cloacal gland (a site of foam synthesis) and other tissues such as breast muscle, testes, brain, kidney and plasma. 2. Fifty-four healthy male Japanese quail were selected at random from a flock, maintained under uniform husbandry conditions and divided into three groups, each of 18 birds. Group I (control) received 1 ml vehicle (normal saline 0.9% (w/v) NaCl) daily for 12 d through the intraperitoneal route. Birds of groups II and III received ciprofloxacin and pefloxacin by the same route at the rate of 10 and 12 mg/kg body weight, respectively, every day for a similar period. 3. Birds from each group were killed, at 1, 5 and 10 d after the cessation of treatment, to collect the cloacal gland together with other tissues that were analysed for residual drugs. 4. Cloacal gland retained the maximum drug residues of ciprofloxacin (60%) and pefloxacin (80%) on d 10 compared with that on d 1 after drug withdrawal. The drug residues were found 60 and 80% in ciprofloxacin and pefloxacin groups, respectively, in the cloacal gland tissue even on d 10 after withdrawal of the treatment. 5. In the ciprofloxacin-treated group, all tissues except cloacal gland contained very small amounts of the drug residues on d 10 after treatment ended. In the pefloxacin group the cloacal gland, breast muscle and kidney retained a fairly high amount of drug even on d 10 after treatment ceased. No residues of pefloxacin were detectable in testes and brain throughout. 6. In conclusion, the cloacal gland in Japanese quail acted as the largest sink for the fluoroquinolone drugs. Ciprofloxacin was more widely distributed in different tissues and persisted for a shorter period than pefloxacin.
Mohan
J
J
Division of Physiology & Reproduction, Central Avian Research Institute, Izatnagar, India. mohanjagjag@rediffmail.com
Sastry
K V H
KV
Tyagi
J S
JS
Rao
G S
GS
Singh
R V
RV
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D002988:Cloaca / Q000378:metabolism*; D003370:Coturnix / Q000097:blood / Q000378:metabolism*; D004350:Drug Residues / Q000493:pharmacokinetics*; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D015366:Pefloxacin / Q000493:pharmacokinetics*; D013737:Testis / Q000378:metabolism; D013997:Time Factors
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015366:Pefloxacin; D002939:Ciprofloxacin