Photographic estimation of the duration of high dose intravitreal triamcinolone in the vitrectomised eye.
OBJECTIVE
To determine the duration of residence of triamcinolone in the vitrectomised eye.


METHODS
23 eyes of 23 patients underwent intravitreal injection of high dose (20 mg) decanted triamcinolone acetonide (Kenalog) at the conclusion of vitrectomy surgery or in previously vitrectomised eyes with macular oedema from diabetes, uveitis, cataract surgery, or other surgery.


RESULTS
The median time to disappearance of triamcinolone in the vitrectomised eye was 113 days (95% confidence interval (CI) 85 to 191). In the phakic eyes the median time to disappearance was 191 days (95% CI 148 to 191). In the pseudophakic eyes the median time to disappearance was 102 days (95% CI 85 to 113). This difference was not significant (p = 0.12). There were no cases of endophthalmitis or severe inflammatory reaction. Five eyes (22%) experienced intraocular pressure rise >/=10 mm Hg.


CONCLUSIONS
High dose decanted intravitreal triamcinolone has a median residence time of 113 days in the vitrectomised eye. Although this appears to be shorter than in the non-vitrectomised eye, this study suggests that a sufficient duration of action will be present to be clinically useful.
Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, 9415 Campus Point Drive, La Jolla, CA 92093-0946, USA.
B R
BR
Kosobucki
W R
WR
Freeman
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L
Cheng
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006801:Humans; D007267:Injections; D008269:Macular Edema / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010781:Photography; D011446:Prospective Studies; D019591:Pseudophakia / Q000378:metabolism; D016019:Survival Analysis; D014222:Triamcinolone Acetonide / Q000493:pharmacokinetics*; D014821:Vitrectomy; D014822:Vitreous Body
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide