Treatment of linear IgA bullous dermatosis of childhood with flucloxacillin.
BACKGROUND
Linear IgA bullous dermatosis of childhood is a rare autoimmune bullous disease that mainly affects preschool-aged children. Dapsone is considered the first-line therapy with prompt response from most patients. However, it may be contraindicated in certain conditions such as glucose-6-phosphate dehydrogenase deficiency.


OBJECTIVE
We sought to assess the efficacy of flucloxacillin in the treatment of linear IgA bullous dermatosis.


METHODS
This is an observational study in which all confirmed cases of linear IgA bullous dermatosis (by both histological and immunofluorescence studies) will be treated with flucloxacillin. Flucloxacillin will be continued according to the response or otherwise will be discontinued after 8 weeks in the case of resistance.


RESULTS
We describe 7 patients with linear IgA bullous dermatosis of childhood treated with flucloxacillin. In 4 cases, it induced complete remission within 3 to 4 months of starting therapy with no relapses. In the other 3 cases, it successfully controlled the disease but with prompt relapse on discontinuation of the treatment.


CONCLUSIONS
This is a case series study with a small number of patients.


CONCLUSIONS
Flucloxacillin may be considered among the first alternative therapies for linear IgA bullous dermatosis of childhood. Further evaluation of the efficacy and safety of the long-term use is required.
Alajlan
Abdulmajeed
A
Department of Dermatology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia. drajlan@yahoo.com
Al-Khawajah
Marwan
M
Al-Sheikh
Omar
O
Al-Saif
Fahad
F
Al-Rasheed
Saleh
S
Al-Hoqail
Ibrahim
I
Hamadah
Issam R
IR
D002648:Child; D002675:Child, Preschool; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use*; D006801:Humans; D007070:Immunoglobulin A; D007223:Infant; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy*
D007070:Immunoglobulin A; D005436:Floxacillin