Effects of vitamin E against aluminum neurotoxicity in rats.
The present study examined the protective effects of vitamin E against aluminum-induced neurotoxicity in rats. Wistar rats were given daily aluminum via their drinking water containing 1600 mg/liter aluminum chloride for six weeks. Aluminum induced a significant increase in lipid peroxidation (LPO) in hippocampus and frontal cortex. Furthermore, aluminum caused marked elevation in the levels of the glial markers (glial fibrillary acidic protein (GFAP) and S100B) and proinflammatory cytokines (TNF-alpha and IL-1beta) in both brain areas. Vitamin E treatment reduced the contents of glial markers and cytokines and the levels of LPO. In conclusion, this study demonstrates that vitamin E ameliorates glial activation and reduces release of proinflammatory cytokines induced by aluminum.
Department of Biophysics and Biochemistry, Faculty of Biology, Dnepropetrovsk National University, Ukraine. nedzvetskyvictor@ukr.net
V S
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Nedzvetsky
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M
Tuzcu
A
A
Yasar
A A
AA
Tikhomirov
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G
Baydas
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D001923:Brain Chemistry; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007375:Interleukin-1 / Q000032:analysis; D015227:Lipid Peroxidation; D008297:Male; D009414:Nerve Growth Factors / Q000032:analysis; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D007375:Interleukin-1; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; D014409:Tumor Necrosis Factor-alpha; D014810:Vitamin E; D000535:Aluminum