Naloxone during neonatal resuscitation: acknowledging the unknown.
There are no studies to support or to refute the current recommendations regarding naloxone concentration, routes for administration, and doses in neonatal resuscitation in the delivery room. Given the lack of supporting evidence, naloxone should not be given routinely in the delivery room to depressed neonates whether or not they are exposed to opioids before delivery because no important improvement has been documented and the drug may have potential short- and long-term harmful effects.
Guinsburg
Ruth
R
Department of Pediatrics, Division of Neonatal Medicine, Federal University of São Paulo, Rua Vicente Félix 77/09, São Paulo, SP 01410-020, Brazil. ruthgbr@netpoint.com.br
Wyckoff
Myra H
MH
D016362:Analgesia, Obstetrical / Q000009:adverse effects; D000818:Animals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009270:Naloxone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D012151:Resuscitation / Q000379:methods*
D009292:Narcotic Antagonists; D009270:Naloxone