[Monoclonal gammopathies of undetermined significance].
Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum <30 g/L and bone marrow plasma cells <10% by the exclusion of multiple myeloma or lymphoproliferative disorders. In most MGUS, however, populations of normal and myelomatous plasma cells coexist in a stable ratio. The overall relative risk for progression is 7 times the expected rate, depending from the disease and the type of M component.
Service des maladies du sang, CHU et UFR médecine, UPRES EA 3863, Angers. NoIfrah@chu-angers.fr
Norbert
N
Ifrah
Marc
M
Zandecki
D001797:Blood Protein Electrophoresis; D003937:Diagnosis, Differential; D019337:Hematologic Neoplasms / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D010265:Paraproteinemias / Q000097:blood / Q000145:classification / Q000175:diagnosis
D007070:Immunoglobulin A; D007075:Immunoglobulin M