Virulence factors and antifungal susceptibility of Candida albicans isolates from oral candidosis patients and control individuals.
Sixty isolates of Candida albicans, 30 obtained from the oral cavity of denture wearers presenting signs of candidosis and 30 obtained from the oral cavity of denture wearers with normal palatal mucosa were assayed for phospholipase and proteinase production, as well as for adherence to buccal epithelial cells. Likewise, susceptibility of the isolates to antifungals was determined by the NCCLS reference method and the E-test method. Proteinase activity was increased among the strains obtained from oral candidosis patients. In contrast, no significant differences between the two groups of isolates were observed in their adherence ability in vitro, in phospholipase production, and susceptibility to antifungal drugs.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônìo Carlos, 6627, P.O. Box 486, 31270-901, Belo Horizonte, MG, Brazil.
Cristiane Yumi
CY
Koga-Ito
Juliana Pereira
JP
Lyon
Valerio
V
Vidotto
Maria Aparecida
MA
de Resende
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000382:microbiology*; D002448:Cell Adhesion / Q000502:physiology; D003778:Dentures; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D010447:Peptide Hydrolases / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism
D000935:Antifungal Agents; D037521:Virulence Factors; D010740:Phospholipases; D010447:Peptide Hydrolases