Novel approach to analyzing the carcinogenic effect of ionizing radiations.
OBJECTIVE
Cancer incidence of ionizing radiations exposure is considered to be proportional to the absorbed dose. However, there are disagreements between substantial amounts of epidemiological studies. In this study, we question the basic relationship of the risk estimate with total accumulated dose, and reanalyse available data on the basis of a daily dose concept.


METHODS
The data analysed were relative mortality risk from all cancers vs. total-body dose on a daily basis. References have been selected on the basis of objective criteria.


RESULTS
We found that this relationship removes major discrepancies. It revises estimates of low-level exposures, with consequences regarding nuclear power plants safety, wastes management, medical applications or homeland security.


CONCLUSIONS
The idea that the dose rate may have a significant impact on health effects of ionizing radiations is not new, but has always been considered as a parameter in models based on integrated dose. The novel approach in this paper is to consider the primary relevant parameter as an average of dose rate over a time period of one day. This is an argument to revise the whole philosophy in radioprotection, and place regulatory limits on specific locations instead of annual limits relevant to individual persons.
Gregoire
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olivier_gregoire@yahoo.com
Cleland
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MR
D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011835:Radiation Protection; D011839:Radiation, Ionizing; D012306:Risk