Conjugated linoleic acid preserves muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Conjugated linoleic acid (CLA), which is found in dairy products, reduces synthesis of tumor necrosis factor-alpha (TNFa), a pro-inflammatory cytokine that plays a major role in tumor-induced skeletal muscle wasting (SMW). The B16 melanoma expresses TNFa mRNA, and induced SMW with no change in muscle levels of TNFa type 1 receptor (TNFR1) protein. A diet containing .5% CLA had no effect on SMW or TNFR1 in mice bearing B16 tumors. In contrast, the Lewis lung carcinoma expresses low levels of TNFa mRNA, induced SMW, and increased muscle levels of TNFR1. A diet containing .5% CLA reduced SMW, but had no effect on muscle levels of TNFR1. We conclude that that tumor-induced SMW can occur independent of muscle levels of TNFR1. Further study is needed before CLA can be tested in persons with cancer cachexia.
Laboratory of Symptom Management, National Institute of Nursing Research, NIH, Bethesda, MD, USA.
Donna O
DO
McCarthy
Erin
E
Graves
D000704:Analysis of Variance; D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000517:prevention & control*; D018827:Carcinoma, Lewis Lung; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008297:Male; D008546:Melanoma, Experimental; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000150:complications*; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D014409:Tumor Necrosis Factor-alpha