Green oxidations with laccase-mediator systems.
Laccases are oxidase enzymes produced by 'white rot' fungi as part of a complex armoury of redox enzymes used to break down lignin--part of the carbon cycle of nature. Laccases alone or in combination with redox co-catalysts have been shown to oxidize xenobiotic compounds under conditions that can be described as 'green'. This paper describes some novel oxidations using the laccase-mediator method and some current limitations to the use of this technology.
Process R&D, AstraZeneca, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK. andrew.wells@astrazeneca.com
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D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism; D000588:Amines / Q000737:chemistry / Q000378:metabolism; D003116:Color; D006900:Hydroxylation; D042845:Laccase / Q000378:metabolism*; D010084:Oxidation-Reduction; D013457:Sulfur Compounds / Q000737:chemistry / Q000378:metabolism
D000447:Aldehydes; D000588:Amines; D013457:Sulfur Compounds; D042845:Laccase