Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes.
Thioredoxins fulfill a number of different important cellular functions in all living organisms. In bacteria, thioredoxin genes are often regulated by external factors. In turn, thioredoxins influence the expression of many other genes. The multiple and important functions of thioredoxins in cells necessitate to appropriately adjust their level. This review outlines different strategies that have evolved for the regulation of bacterial thioredoxin genes. It also summarizes effects of thioredoxins on gene regulation and presents a recent model for a redox-dependent gene regulation that is mediated by thioredoxins.
Zeller
Tanja
T
Institut für Mikrobiologie und Molekularbiologie, University of Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
Klug
Gabriele
G
D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D004261:DNA Replication; D015964:Gene Expression Regulation, Bacterial; D018384:Oxidative Stress; D013455:Sulfur / Q000378:metabolism; D013879:Thioredoxins / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D013879:Thioredoxins; D013455:Sulfur