Hepatoprotective effect of a hot-water extract from the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice.
The edible thorny oyster, Spondylus varius (Mizuiri-shoujou), was found to suppress the carbon tetrachloride-induced increase in serum aspartate and alanine aminotransferase activities in mice. Significant suppressive effects on these enzyme activities were found in the fraction eluted with 75% ethanol from polystyrene gel in a dose-dependent manner. These results suggest that S. varius exerts a protective effect against liver injury.
Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya. Japan.
Tomoyuki
T
Koyama
Ritsu
R
Chounan
Daisuke
D
Uemura
Kohji
K
Yamaguchi
Kazunaga
K
Yazawa
D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors / Q000097:blood; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury; D005502:Food; D006358:Hot Temperature; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D049897:Pectinidae / Q000737:chemistry*; D014020:Tissue Extracts / Q000494:pharmacology*; D014867:Water / Q000737:chemistry*
D014020:Tissue Extracts; D014867:Water; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase