Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.
Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
Prescott
James H
JH
MicroCHIPS Inc., 6-B Preston Court, Bedford, Massachusetts 01730, USA.
Lipka
Sara
S
Baldwin
Samuel
S
Sheppard
Norman F
NF
Maloney
John M
JM
Coppeta
Jonathan
J
Yomtov
Barry
B
Staples
Mark A
MA
Santini
John T
JT
D000818:Animals; D004285:Dogs; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015918:Infusion Pumps, Implantable; D016729:Leuprolide / Q000008:administration & dosage*; D008297:Male; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization; D013686:Telemetry / Q000295:instrumentation*
D016729:Leuprolide