Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals.
The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine N,N'-dioxide.
School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India.
L Sreenivas
LS
Reddy
N Jagadeesh
NJ
Babu
Ashwini
A
Nangia
D000577:Amides / Q000737:chemistry*; D003460:Crystallization; D015195:Drug Design; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*
D000577:Amides; D011725:Pyridines; C013229:pyridine N-oxide