Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
Kondo
Tetsuo
T
Department of Pathology, University Health Network and Toronto Medical Laboratories, Department of Laboratory Medicine and Pathology, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.
Ezzat
Shereen
S
Asa
Sylvia L
SL
D018263:Adenocarcinoma, Follicular / Q000235:genetics* / Q000473:pathology; D000818:Animals; D002869:Chromosome Aberrations; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
D011518:Proto-Oncogene Proteins