Comparison of antifungal activity of white-colored and gray-colored mineral trioxide aggregate (MTA) at similar concentrations against Candida albicans.
The killing effect of similar concentrations of white-colored MTA and gray-colored MTA against Candida albicans was assessed in vitro using the tube dilution test. A direct correlation was found between MTA concentration and its killing effect on C. albicans. At time period zero, both white-colored and gray-colored MTA samples showed Candida growth regardless of the concentration. Tubes containing gray-colored MTA in concentrations of 50, 25, 12.5, 6.25, and 3.125 mg/ml and tubes containing white-colored MTA in concentrations of 50 and 25 mg/ml did not show C. albicans growth at any of the other time periods tested. Tubes containing white-colored MTA in concentrations of 12.5 mg/ml or less showed Candida growth at all the time periods tested. Statistically, a significant difference was found between tubes containing either 50 mg/ml or 25 mg/ml and tubes containing lower concentrations of white-colored MTA (p < 0.001). A significant difference was also found between tubes containing gray-colored MTA in concentrations of 12.5 mg/ml or less and tubes containing similar concentrations of white-colored MTA (p < 0.001). It appears that both gray-colored and white-colored MTA in concentrations of 50 mg/ml and 25 mg/ml are effective in killing C. albicans for periods of up to 1 wk. Lower concentrations of gray-colored MTA may still be effective while lower concentrations of white-colored MTA may not.
Al-Hezaimi
Khalid
K
King Saud University, College of Dentistry, Riyadh, Saudi Arabia.
Naghshbandi
Jafar
J
Oglesby
Samuel
S
Simon
James H S
JH
Rotstein
Ilan
I
D017607:Aluminum Compounds / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004395:Dye Dilution Technique; D008826:Microbial Sensitivity Tests; D010087:Oxides / Q000494:pharmacology*; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*; D018709:Statistics, Nonparametric
D017607:Aluminum Compounds; D000935:Antifungal Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate