Articaine and lidocaine mandibular buccal infiltration anesthesia: a prospective randomized double-blind cross-over study.
This randomized crossover double-blind trial compared the efficacy of buccal infiltration with 4% articaine and 2% lidocaine (both with 1:100,000 epinephrine) in securing mandibular first molar pulp anesthesia. Injections were given at least 1 week apart in 31 healthy adult volunteers. Electronic pulp testing was undertaken at baseline and at 2 minute intervals until 30 minutes postinjection. A successful outcome was recorded in the absence of pulp sensation on two consecutive maximal pulp tester stimulations (80 muA). 64.5% of articaine and 38.7% of lidocaine infiltrations were successful (p = 0.008). Articaine infiltration produced significantly more episodes of no response to maximum stimulation in first molars than lidocaine (236 and 129, respectively, p < 0.001). Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. Both injections were associated with mild discomfort.
Department of Oral and Maxillofacial Surgery, School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, England.
Mohammad Dib
MD
Kanaa
John Martin
JM
Whitworth
Ian Porter
IP
Corbett
John Gerard
JG
Meechan
D000278:Administration, Buccal; D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002355:Carticaine / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D003791:Dental Pulp Test; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008340:Mandibular Nerve; D008963:Molar; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D000779:Anesthetics, Local; D008012:Lidocaine; D002355:Carticaine