Neurological diseases that cause detrusor hyperactivity with impaired contractile function.
OBJECTIVE
Detrusor hyperactivity with impaired contractile function (DHIC) was originally described in elderly women. It has not previously been well known whether neurological diseases cause DHIC. We investigated which neurological diseases commonly cause DHIC in our laboratory.


METHODS
We searched for DHIC in our laboratory's computerized database of 1,514 case records, which included a lower urinary tract (LUT) symptom questionnaire and urodynamic study results. DHIC was defined as the presence of both (1) detrusor overactivity during the storage phase, and (2) underactive detrusor contraction during the evacuation phase.


RESULTS
Two hundred and seventeen patients met the criteria for DHIC: 122 men and 95 women; mean age, 63 years. The neurological diseases that caused DHIC included Parkinsonian syndrome (18%), multiple system atrophy (18%), progressive supranuclear palsy/corticobasal degeneration (14%), multiple cerebral infarction (MCI) (12%), multiple sclerosis/acute disseminated encephalomyelitis (18%), spinal cord lesions (15%), and cervical spondylotic myelopathy (CS) (10%).


CONCLUSIONS
The present study revealed that a wide spectrum of neurological disorders could cause DHIC.
Department of Neurology, Chiba University, Chiba, Japan. tatsuya-yamamoto@mbc.nifty.com
Tatsuya
T
Yamamoto
Ryuji
R
Sakakibara
Tomoyuki
T
Uchiyama
Zhi
Z
Liu
Takashi
T
Ito
Yusuke
Y
Awa
Tomonori
T
Yamanishi
Takamichi
T
Hattori
D000328:Adult; D000368:Aged; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009122:Muscle Hypertonia / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D009422:Nervous System Diseases / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D011795:Surveys and Questionnaires; D014563:Urodynamics