Catastrophic antiphospholipid syndrome related to severe ovarian hyperstimulation.
Antiphospholipid syndrome (APS) is a cause of infertility and fetal loss. Ovarian stimulation can induce previously unknown APS. Ovarian hyperstimulation syndrome (OHS) is uncommon but potentially life-threatening, as well as catastrophic APS. A woman that simultaneously developed a severe OHS and a catastrophic APS is described in this paper. Both entities produced thrombotic cardiac and brain thrombosis. A peculiar mechanism of cardiac ischemia is also described. In spite of the life-threatening risk of this situation, the indication for preventive anti-aggregation and/or anticoagulation is not clear.
Giner
V
V
Department of Internal Medicine, Hospital Clínico Universitario, University of Valencia, 46010, Valencia, Spain. giner_vicgal@gva.es
Oltra
M R
MR
Esteban
M J
MJ
García-Fuster
M J
MJ
Salvador
A
A
Núñez
J
J
Redón
J
J
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001014:Aortic Aneurysm / Q000209:etiology* / Q000601:surgery; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology*; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000276:immunology*; D012850:Sinus of Valsalva; D020521:Stroke / Q000209:etiology*; D013927:Thrombosis