Increased prevalence of interleukin-1 receptor antagonist gene polymorphism in patients with chronic rhinosinusitis.
OBJECTIVE
To assess the association of the interleukin (IL)-1beta and the IL-1 receptor antagonist (IL-1Ra) gene polymorphisms with chronic rhinosinusitis (CRS).


METHODS
Genotyping of the 2 IL-1beta gene (IL1B) polymorphisms (promoter and exon) and the IL-1Ra gene (IL1RN) polymorphism (intron 2) was performed using polymerase chain reaction and restriction length fragment polymorphism analyses.


METHODS
Prospective study, tertiary medical center.


METHODS
The study population comprised 88 consecutive adult Taiwan-Chinese patients who met stringent criteria for CRS and received endoscopic sinus surgery and 103 healthy volunteers of the same ethnicity and similar age range. Of the 88 patients, 61 had CRS with nasal polyps, while the other 27 had CRS without nasal polyps.


RESULTS
There were significant differences in the distribution of the IL1RN polymorphism between the control subjects and patients with CRS (P<.05). The II allele of IL1RN occurred more frequently in the CRS patient group, and the odds ratio for subjects with I/II genotype was 3.39 (95% confidence interval, 1.25-9.18). In the case of CRS without nasal polyps, the odds ratio for subjects with I/II genotype was further increased to 4.75 (1.39-16.25). There was no association between the other 2 polymorphisms of IL1B and CRS.


CONCLUSIONS
Increased prevalence of IL1RN polymorphism in patients with CRS suggests that this polymorphism, or a polymorphism in linkage disequilibrium with it, may be involved in the development of CRS.
Cheng
Yuan-Kai
YK
Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan.
Lin
Chia-Der
CD
Chang
Weng-Cheng
WC
Hwang
Guang-Yuh
GY
Tsai
Shih-Wei
SW
Wan
Lei
L
Tsai
Ming-Hsui
MH
Tsai
Jeffrey J P
JJ
Tsai
Fuu-Jen
FJ
D000328:Adult; D044466:Asian People / Q000235:genetics; D002908:Chronic Disease; D005091:Exons; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics; D008297:Male; D009298:Nasal Polyps / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012795:Sialoglycoproteins / Q000235:genetics*; D012852:Sinusitis / Q000235:genetics*; D013624:Taiwan
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins