Modulation of lymphocyte migration to the murine spleen after marginal zone macrophage phagocytosis of blood-borne particulate material.
Our previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocyte Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity.
Division of Haematology and Hanson Institute, The Institute of Medical and Veterinary Science, Adelaide, SA, Australia. Bruce.Lyons@imvs.sa.gov.au
A
A
Bruce Lyons
Marcus
M
Watkins
Campbell C
CC
Simpson
H
H
Konrad Muller
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002244:Carbon / Q000097:blood / Q000276:immunology; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000235:genetics; D004338:Drug Combinations; D005260:Female; D007156:Immunologic Memory; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D011205:Povidone; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D015854:Up-Regulation
D054382:Chemokine CXCL13; D019743:Chemokines, CXC; C486386:Cxcl13 protein, mouse; D004338:Drug Combinations; D012333:RNA, Messenger; C078073:carbon colloid; D002244:Carbon; D011205:Povidone