The ABC of the BX-C: the bithorax complex explained.
As one of two Drosophila Hox clusters, the bithorax complex (BX-C) is responsible for determining the posterior thorax and each abdominal segment of the fly. Through the dissection of its large cis-regulatory region, biologists have obtained a wealth of knowledge that has informed our understanding of gene expression, chromatin dynamics and gene evolution. This primer attempts to distill and explain our current knowledge about this classic, complex locus.
Maeda
Robert K
RK
Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, 30 quai E. Ansermet, 1211 Geneva-4, Switzerland.
Karch
François
F
D000818:Animals; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D004331:Drosophila melanogaster / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D005810:Multigene Family; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology
C062393:Abd-B proteins, Drosophila; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; C066591:abd-A protein, Drosophila