Drug delivery matrices based on scleroglucan/alginate/borax gels.
The aim of this work is to obtain a new drug delivery matrix, especially designed for protein delivery, based on biodegradable and biocompatible polymers, and to describe its main physico-chemical properties. A polysaccharide based semi-interpenetrating polymer network (semi-IPN) was built up, composed by sodium alginate chains interspersed into a scleroglucan/borax hydrogel network. Tablets were obtained by compression of the resulting freeze-dried hydrogel. The different release and physico-chemical properties possessed by the two starting polymers in various aqueous media were combined in the new matrix. In this work, description is given of the in vitro ability of the matrix to deliver in a controlled manner a protein, Myoglobin, in distilled water, simulated gastric fluid and simulated intestinal fluid; the release, simulating a gastric passage, followed by an enteric delivery, was also carried out. Water uptake data, colorimetric experiments and scanning electron microscopy images are given for the characterization of this new solid dosage form; the importance of the borax presence is also discussed.
Matricardi
Pietro
P
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
Onorati
Ilenia
I
Coviello
Tommasina
T
Alhaique
Franco
F
D000464:Alginates / Q000737:chemistry*; D001881:Borates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D005612:Freeze Drying; D005782:Gels; D005936:Glucans / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D009211:Myoglobin / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013608:Tablets, Enteric-Coated
D000464:Alginates; D001881:Borates; D004337:Drug Carriers; D005782:Gels; D005936:Glucans; D006603:Hexuronic Acids; D009211:Myoglobin; D013608:Tablets, Enteric-Coated; C018851:borax; C045938:scleroglucan; D020723:Glucuronic Acid