Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation.
Hemoglobin-Vesicles (HbV; diameter, 250 nm) are artificial O2 carriers encapsulating purified and concentrated human Hb solution in phospholipid vesicles (liposomes), and their safety and efficacy, as a transfusion alternative, have been studied. In this paper, we summarized the characteristics of HbV that have been clarified by the microcirculatory observations.
Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. hiromi@waseda.jp
Hiromi
H
Sakai
Eishun
E
Tsuchida
D001802:Blood Substitutes / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D006454:Hemoglobins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008081:Liposomes; D008833:Microcirculation / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*
D001802:Blood Substitutes; D004337:Drug Carriers; D006454:Hemoglobins; D008081:Liposomes; C109960:PEG-hemoglobin; D011092:Polyethylene Glycols; D010100:Oxygen