Cytokines, skin, and smallpox-a new link to an antimicrobial Peptide.
Patients with atopic dermatitis (AD) have an increased risk of infection with several viruses compared to patients with other inflammatory skin disorders such as psoriasis. In this issue of Immunity, it is found that the cytokine milieu in the skin of AD patients profoundly affects the innate response to vaccinia virus (VV) by blocking production of the antimicrobial peptide LL-37.
The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Jodie M
JM
Harrison
Ian A
IA
Ramshaw
D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis*; D016207:Cytokines / Q000502:physiology*; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016328:NF-kappa B / Q000502:physiology; D012867:Skin / Q000276:immunology* / Q000821:virology; D012900:Smallpox Vaccine / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology* / Q000502:physiology; D014779:Virus Replication; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; D016328:NF-kappa B; D012900:Smallpox Vaccine; D054804:Cathelicidins