Incidental mononuclear cell infiltrate in the uvea of cynomolgus monkeys.
Mononuclear cell infiltrate (MCI) in the uvea was observed in naïve, untreated (control group) cynomolgus monkeys in approximately 25% of drug safety evaluation studies. The total incidence of MCI in the choroid and the ciliary body was 29% of 342 males and 25% of 306 female monkeys. In the studies in which MCI was present in the ciliary body or choroid, the incidence was as high as 75%. There were no other ocular histopathologic findings in these monkeys. All monkeys were clinically healthy and the eyes were not remarkable when examined ophthalmoscopically.
Department of Drug Safety and Metabolism, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA. dineshwar.sinha@spcorp.com
Dinesh P
DP
Sinha
Mark E
ME
Cartwright
Robert C
RC
Johnson
D000818:Animals; D002829:Choroid / Q000473:pathology; D002924:Ciliary Body / Q000473:pathology; D005260:Female; D007498:Iris / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D018675:Toxicity Tests; D014602:Uvea / Q000473:pathology*; D014605:Uveitis / Q000473:pathology / Q000662:veterinary*