Cryopyrin: in from the cold.
Mutations in CIAS1/cryopyrin are linked to several autoinflammatory diseases. In this issue of Immunity, a critical role for cryopyrin in the caspase-1/IL-1beta axis and reveal a broader role for cryopyrin than anticipated is uncovered.
Lich
John D
JD
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Arthur
Janelle C
JC
Ting
Jenny P-Y
JP
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D020170:Caspase 1 / Q000502:physiology*; D004789:Enzyme Activation; D007113:Immunity, Innate; D007375:Interleukin-1 / Q000502:physiology; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
D002352:Carrier Proteins; D007375:Interleukin-1; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D020170:Caspase 1