Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg i.p.) in mice was antagonized by all adenosine receptor agonists: CPA--A1 receptor agonist, CGS 21680--A2 receptor agonist, and NECA--A1/A2 receptor agonist, but the effect of NECA was the most apparent. Locomotion induced by the threshold dose of dizocilpine (0.05 mg/kg i.p.) was enhanced by DPMX (A2A adenosine receptor antagonist) and by the theophylline (A1 and A2 receptor antagonist), but not by A1 receptor antagonist--CPT. These data suggest that adenosinergic system is involved in the mechanism of dizocilpine-induced hyperactivity, and it seems that A2A adenosine receptor plays a more important role.
Department of Pharmacodynamics, Skubiszewski Medical University of Lublin, Staszica 4, PL 20-081 Lublin, Poland.
Danuta
D
Malec
Ewa
E
Poleszak
D058908:Adenosine A2 Receptor Agonists; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004336:Drug Antagonism; D006948:Hyperkinesis; D008024:Ligands; D008124:Locomotion; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1 / Q000502:physiology*
D058908:Adenosine A2 Receptor Agonists; D008024:Ligands; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1; D016291:Dizocilpine Maleate