Use of autologous platelet concentrate in blepharoplasty surgery.
OBJECTIVE
To evaluate postoperative edema and ecchymosis after blepharoplasty surgery with or without autologous platelet gel.


METHODS
In this prospective, randomized, controlled trial, patients received autologous platelet concentrate in the eyelid incisions of one side during bilateral blepharoplasty surgery. The opposing eye was not treated and was used as a control. Autologous platelet concentrate was prepared by the Harvest system (Harvest Technologies, Plymouth, MA, U.S.A.). The blood was centrifuged and platelet-rich plasma isolated. Platelet-rich plasma was mixed with thrombin and instilled in the wound on a randomly selected side before wound closure. Patients were examined and completed a questionnaire at postoperative days 1, 3, 7, and 30. Photographs were taken at each visit and were graded by masked, trained observers for edema and ecchymosis.


RESULTS
Significantly less edema (p<0.05) was noted by the photograders at day 1 and by the patients at day 30. There were non-statistically significant trends toward decreased ecchymosis and edema in the treated group. Questionnaire data showed no significant difference in postoperative pain between the treated and untreated sides. Photographic and questionnaire data showed no clinically meaningful difference between the treated and control sides.


CONCLUSIONS
Although there were statistically significant differences in edema using autologous platelet gel in blepharoplasty surgery, trends toward improvement in postoperative edema and ecchymosis did not achieve clinical significance.
Premier Medical Eye Group, Mobile, Alabama, USA.
Valerie L
VL
Vick
John B
JB
Holds
Morris E
ME
Hartstein
Ryan M
RM
Rich
Brent R
BR
Davidson
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019882:Blepharoplasty / Q000379:methods*; D001804:Blood Transfusion, Autologous; D005141:Eyelid Diseases / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000379:methods*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014945:Wound Healing