Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI).
To test whether MHC alleles associated with common variable immune deficiency (CVID) might also be over-represented in patients with normal serum immunoglobulin levels who suffer with recurrent sinopulmonary infections (RESPI), we identified 62 consecutive RESPI patients and compared their HLA-B and HLA-DR antigen frequencies to those of 60 consecutive patients with CVID, 1627 Alabama Caucasian bone marrow donors, and 997,230 published US Caucasians. Either HLA-B44, -B8, -DR3(17), or -DR7 was present in 74% of the RESPI and 85% of the CVID patients. HLA-B44 prevalence in particular proved identical between RESPI and CVID. When compared to US Caucasians, the increased prevalence of the four HLA alleles proved significant at P < 0.0001, P < 0.0001, P = 0.0005, and P = 0.02, respectively. When compared to Alabama Caucasians, only the increased prevalence of HLA-B44 achieved statistical significance (P = 0.0001). Inheritance of HLA-B44 may yield susceptibility to recurrent sinopulmonary infection even in the presence of normal serum immunoglobulin levels.
Johnston
Douglas T
DT
University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-3300, USA. djohnston@peds.uab.edu
Mehaffey
Gregory
G
Thomas
Judy
J
Young
K Randall
KR
Wiener
Howard
H
Li
Jian
J
Go
Rodney C P
RC
Schroeder
Harry W
HW
D000293:Adolescent; D000328:Adult; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D059948:HLA-B44 Antigen; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000097:blood / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D044465:White People / Q000235:genetics
D015235:HLA-B Antigens; D059948:HLA-B44 Antigen; D006684:HLA-DR Antigens; D007136:Immunoglobulins