Atypical antipsychotic usage-related higher serum leptin levels and disabled lipid profiles in euthymic bipolar patients.
Atypical antipsychotics (AA)-induced weight gain is associated with increased leptin levels. AA have been increasingly used in the treatment of bipolar disorders. This cross-sectional study aimed to evaluate the association between serum leptin and lipid profiles considering the drug treatments in euthymic bipolar outpatients. Leptin and lipid profiles were compared, and no differences were noted in leptin, cholesterol, and low-density lipoprotein levels among the patients and controls. Glucose, very-low-density lipoprotein, and triglyceride levels in patients were higher than in controls, while high-density lipoprotein levels were low. Patients were divided into three groups according to their type of drug usage: AA users, AA + mood stabilizer users, and mood stabilizer users. Each group of patients was compared with a healthy control group for mentioned biochemical parameters. Lipid profiles were disordered by using both AA and mood stabilizers, but higher leptin levels are associated with AA usage. However, leptin does not seem to be responsible for dyslipidemia caused by AA or mood stabilizers in euthymic bipolar patients.
Department of Physiology, Medical Faculty, Gaziantep University, Gaziantep, Turkey.
H Serdar
HS
Gergerlioglu
Haluk A
HA
Savas
Ahmet
A
Celik
Esen
E
Savas
Mehmet
M
Yumru
Mehmet
M
Tarakcioglu
Nursadan
N
Gergerlioglu
Murad
M
Atmaca
D000293:Adolescent; D000328:Adult; D018692:Antimanic Agents / Q000097:blood / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000097:blood / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D001786:Blood Glucose / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D020738:Leptin / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001786:Blood Glucose; D020738:Leptin; D008074:Lipoproteins; D002784:Cholesterol