Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes.
As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095-1747, USA.
Livia
L
Pedroza-Martins
W John
WJ
Boscardin
Deborah J
DJ
Anisman-Posner
Beverly N
BN
Redsar
Yvonne J
YJ
Bryson
Otto O
OO
Yang
Christel H
CH
Uittenbogaart
D002478:Cells, Cultured; D002648:Child; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D016176:T-Lymphocyte Subsets / Q000821:virology*; D013950:Thymus Gland / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects
D007371:Interferon-gamma