Oncogene-induced senescence: putting the brakes on tumor development.
Cellular senescence, a permanent cell cycle arrest, is considered a safeguard mechanism that may prevent aged or abnormal cells from further expansion. Although the term "replicative senescence" stands for the widely accepted model of a terminal growth arrest due to telomere attrition, the significance of "oncogene-inducible senescence" remained an issue of debate over the years. A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery.
Braig
Melanie
M
Department of Hematology/Oncology, Charité-Universitätsmedizin Berlin, Germany.
Schmitt
Clemens A
CA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D009857:Oncogenes / Q000502:physiology*; D011230:Precancerous Conditions / Q000235:genetics