Resveratrol, a red wine constituent polyphenol, protects gastric tissue against the oxidative stress in cholestatic rats.
This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis.
Kirimlioglu
Vedat
V
Department of General Surgery, Inonu University School of Medicine, 44069 Malatya, Turkey.
Ara
Cengiz
C
Yilmaz
Mehmet
M
Ozgor
Dincer
D
Isik
Burak
B
Sogutlu
Gokhan
G
Kirimlioglu
Hale
H
Karabulut
Aysun Bay
AB
Yilmaz
Sezai
S
Kayaalp
Cuneyt
C
Yologlu
Saim
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001652:Bile Ducts / Q000601:surgery; D002779:Cholestasis / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D008026:Ligation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
D000975:Antioxidants; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione; D000077185:Resveratrol