Akt1 in endothelial cell and angiogenesis.
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
Somanath
Payaningal R
PR
Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Razorenova
Olga V
OV
Chen
Juhua
J
Byzova
Tatiana V
TV
D000818:Animals; D042783:Endothelial Cells / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D010766:Phosphorylation; D020033:Protein Isoforms; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction
D020033:Protein Isoforms; D051057:Proto-Oncogene Proteins c-akt