Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats.
Histopathological changes were observed in liver, kidney and muscles of normal, protein-malnourished, diabetic as well as both protein-malnourished and diabetic albino rats when exposed to a mixture of monocrotophos, hexachlorocyclohexane and endosulfan at varying intervals. The examination revealed hepatotoxic, nephrotoxic and muscular necrotic effects in pesticides exposed rats. Toxicity was aggravated in protein-malnourished and diabetic animals and more so, if the animals were both diabetic and protein-malnourished.
Department of Veterinary Biochemistry, College of Veterinary Science & Animal Husbandry, Jabalpur 482001 India.
Nidhi
N
Benjamin
Ameeta
A
Kushwah
R K
RK
Sharma
A K
AK
Katiyar
D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology*; D004726:Endosulfan / Q000494:pharmacology; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D044342:Malnutrition / Q000473:pathology*; D008999:Monocrotophos / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000473:pathology*; D010575:Pesticides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010575:Pesticides; D001556:Hexachlorocyclohexane; D008999:Monocrotophos; D004726:Endosulfan