[Acute obstructive kidney failure during sulfadiazine treatment].
BACKGROUND
Acute obstructive kidney failure can occur during sulfadiazine treatment of cerebral toxoplasmosis in immunocompromised patients.


METHODS
Six days after the patient began sulfadiazine treatment for toxoplasmosis, he developed low back pain radiating into the abdomen and kidney failure with obstructive uropathy, followed by anuria. Abdominal computed tomography found bilateral pyelocaliceal distention. Six hours after a hemodialysis session, the pain stopped abruptly and abundant diuresis resumed.


CONCLUSIONS
During acute renal failure due to sulfadiazine, simply stopping the drug treatment does not suffice. The massive alkalinization induced by hemodialysis, however, is effective.
Service de réanimation médicale, Hôpital de l'Archet 1, Nice. hyvernat.h@chu-nice.fr
Hervé
H
Hyvernat
Philippe
P
de Swardt
Véronique
V
Mondain
Gilles
G
Bernardin
D000208:Acute Disease; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000139:chemically induced*; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000188:drug therapy
D000890:Anti-Infective Agents; D013411:Sulfadiazine