Regional transient osteoporosis of the foot and vitamin C deficiency.
We describe the clinical presentation and diagnostic tests of a patient with regional transient osteoporosis (RTO) of the foot. This patient presented with a 4-month history of left-foot pain, nonpitting edema, and brownish discolorations of both feet. He had a history of tobacco abuse, alcohol abuse, and malnutrition. Radiological studies revealed severe osteopenia in the feet, and a MRI revealed bone marrow edema. The bone biopsy was consistent with RTO. This patient also had vitamin C deficiency. This case suggests a link between vitamin C deficiency and RTO, a hypothesis supported by our review of relevant literature on osteoporosis and vitamin C.
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street STOP 9410, Lubbock, TX 79430, USA.
Sandra
S
Rodriguez
Oscar
O
Paniagua
Kenneth M
KM
Nugent
Michael P
MP
Phy
D001205:Ascorbic Acid / Q000627:therapeutic use*; D001206:Ascorbic Acid Deficiency / Q000150:complications* / Q000503:physiopathology; D001851:Bone Diseases, Metabolic; D019587:Dietary Supplements; D005529:Foot Bones / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography
D001205:Ascorbic Acid