Cryopyrin: in from the cold.
Mutations in CIAS1/cryopyrin are linked to several autoinflammatory diseases. In this issue of Immunity, a critical role for cryopyrin in the caspase-1/IL-1beta axis and reveal a broader role for cryopyrin than anticipated is uncovered.
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
John D
JD
Lich
Janelle C
JC
Arthur
Jenny P-Y
JP
Ting
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D020170:Caspase 1 / Q000502:physiology*; D004789:Enzyme Activation; D007113:Immunity, Innate; D007375:Interleukin-1 / Q000502:physiology; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
D002352:Carrier Proteins; D007375:Interleukin-1; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D020170:Caspase 1