Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis.
OBJECTIVE
To determine the association between antibiotic exposure in the first year of life and the development of childhood asthma.


METHODS
Metaanalysis of observational studies retrieved through systematic search of all available electronic data sources. Studies included in the metaanalyses were those with populations exposed to one or more courses of antibiotics during the first year of life, and asthma diagnosis was defined as diagnosis by a physician between the age of 1 to 18 years.


METHODS
Retrospective and prospective studies published in the English-language literature from 1966 to present.


RESULTS
Eight studies (four prospective and four retrospective) examined the association between exposure to at least one course of antibiotics and development of childhood asthma. The total number of subjects for the analysis comparing exposure to at least one antibiotic to no exposure in the first year of life was 12,082 children and 1,817 asthma cases. In the dose-response analysis, we included data from a total of 27,167 children and 3,392 asthma cases. The pooled odds ratio (OR) for the eight studies was 2.05 (95% confidence interval [CI], 1.41 to 2.99). The association was significantly stronger in the retrospective studies (OR, 2.82; 95% CI, 2.07 to 3.85) than the prospective studies (OR, 1.12; 95% CI, 0.88 to 1.42). Five of the eight studies examined whether the association was related to the number of courses of antibiotics taken in the first year of life. The overall OR for the dose-response analysis was 1.16 (95% CI, 1.05 to 1.28) for each additional course of antibiotics; however, this association was not significantly stronger in the retrospective studies (OR, 1.37; 95% CI, 1.18 to 1.60) relative to the prospective studies (OR, 1.07; 95% CI, 0.95 to 1.20).


CONCLUSIONS
Exposure to at least one course of antibiotics in the first year of life appears to be a risk factor for the development of childhood asthma. Because of the limitations of the studies conducted to date, additional large-scale, prospective studies are needed to confirm this potential association.
Health Economics Program, Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Faculty of Pharmaceutical Sciences, University of BC, 828 W Tenth Avenue, Vancouver, BC, V5Z 1L8 Canada.
Fawziah
F
Marra
Larry
L
Lynd
Megan
M
Coombes
Kathryn
K
Richardson
Michael
M
Legal
J Mark
JM
Fitzgerald
Carlo A
CA
Marra
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000453:epidemiology*; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D016017:Odds Ratio; D012107:Research Design; D012307:Risk Factors
D000900:Anti-Bacterial Agents