The interleukin-1 beta +3953 single nucleotide polymorphism: cervical protein concentration and preterm delivery risk.
OBJECTIVE
To determine the associations between preterm delivery <37 weeks (PTD), cervical fluid interleukin-1beta (IL-1beta) concentration, and its +3953 single nucleotide polymorphism (SNP).


METHODS
Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23-32 weeks gestation with preterm labor symptoms and intact membranes.


RESULTS
Increased cervical fluid concentrations of IL-1beta were associated with PTD (P = 0.017) and spontaneous PTD (P = 0.001). Maternal IL-1beta +3953 SNP genotype was associated neither with PTD (P = 0.43) nor with cervical fluid IL-1beta concentrations (P = 0.35). Neonatal IL-1beta +3953 SNP genotype was associated neither with PTD nor cervical IL-1beta concentrations.


CONCLUSIONS
Cervical fluid concentrations of IL-1beta were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL-1beta +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL-1beta nor with risk of PTD.
Edwards
Rodney K
RK
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA. edwardsr@obgyn.ufl.edu
Ferguson
Ronald J
RJ
Duff
Patrick
P
D000328:Adult; D002584:Cervix Uteri / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors
D007375:Interleukin-1