Endometrial carcinosarcoma with osteoclast-like giant cells.
We encountered a case of endometrial cancer with a poorly differentiated epithelial component, accompanied by a compact proliferation of atypical spindle cells and osteoclast-like giant cells. Immunohistochemically, the epithelial component was EMA and prekeratin positive with vimentin-positive spindle cells, whereas the osteoclast-like giant cells were strongly immunoreactive for CD68. The description of osteoclast-like giant cells adds to the knowledge of endometrial carcinosarcoma tumor biology.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Catholic University of Leuven, Leuven, Belgium.
F
F
Amant
I
I
Vandenput
T
T
Van Gorp
I
I
Vergote
Ph
P
Moerman
D001707:Biopsy, Needle; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D010010:Osteoclasts / Q000473:pathology*; D017698:Postmenopause; D035583:Rare Diseases; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000175:diagnosis / Q000209:etiology