Balancing supramolecular reagents for reliable formation of co-crystals.
The rational design and synthesis of a supramolecular reagent (SR) composed of two distinct hydrogen bonding sites (pyrazole-benzamide), and four co-crystals resulting from reactions between this SR and a variety of carboxylic acids are described; the observed primary intermolecular interaction is consistent and predictable in each case.
Aakeröy
Christer B
CB
Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA. aakeroy@ksu.edu
Desper
John
J
Scott
Benjamin M T
BM