An adjoint method for channel localization.
Single cells learn by tuning their synaptic conductances and redistributing their excitable machinery. To reveal its learning rules, one must therefore know how the cell remaps its ion channels in response to physiological stimuli. We here develop an adjoint approach for discerning the non-uniform distribution of a given channel type from knowledge of the time course of membrane potential at two distinct locations following a prescribed injection of current.
Computational and Applied Mathematics, MS 134, Rice University, 6100 Main, Houston, TX 77006, USA. cox@caam.rice.edu
Steven J
SJ
Cox
D000465:Algorithms; D000818:Animals; D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*
D007473:Ion Channels