Functionalized ionic liquids as new supports for peptide coupling and traceless catalyzed carbon-carbon coupling reactions.
A new strategy to obtain pure ionic liquid support with a high loading (3 mmol/g) of primary amino groups is reported. The compatibility of the imidazolium unit was demonstrated with DIC or DCC coupling reactions of protected amino acids and with classical cleavage of BOC or Fmoc protecting groups. In addition, this is the first report of a traceless ionic liquid support based on a silicon linker with a high loading (3 mmol/g) of aryl bromide reactive groups used in a palladium-catalyzed carbon-carbon coupling reaction.
UMR6509, Institut de chimie, CNRS - Université de Rennes 1, Campus de Beaulieu, France.
Fabien
F
Bonnette
Zoia
Z
Mincheva
Olivier
O
Lavastre
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D007477:Ions; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D007477:Ions; D010455:Peptides; D002244:Carbon