[Clinical effect of minocycline as adjunctive therapy to scaling and root planning on treatment of chronic periodontitis].
OBJECTIVE
To evaluate the efficacy of minocycline as an adjunct to scaling and root planning (SRP) in treating chronic periodontitis.


METHODS
64 male smokers with moderate to advanced periodontitis were randomly divided into two groups: SRP alone (SRP) and SRP plus minocycline (SRP+M). All clinical parameters including plaque index (Pll), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and attachment gain were recorded at baseline, 3 and 6 months after treatment.


RESULTS
According to PlI, GI and BOP, there was no significant difference between the two groups at 3 and 6 months after periodontal therapy (1 > 0.05). However, PD reduction and attachment gain were significantly greater for SRP+M than that for SRP (P < 0.05). For SRP+M and SRP groups, PD reduction were 1.98 mm and 1.32 mm, and attachment gain were 1.87 mm and 1.14 mm respectively. Deep pockets in SRP+M group showed more obvious PD reduction (3.48 mm versus 2.21 mm, P < 0.01) and attachment gain (2.62 mm versus 1.23 zmm, P < 0.01) than that in SRP group.


CONCLUSIONS
Treatment with SRP plus locally delivered minocycline is more effective than SRP alone in male smokers with chronic periodontitis. Mechanical debridement plus locally delivered antibiotics are recommended especially for smokers with deep pocket periodontitis.
Zhao
Ning
N
Dept. of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China.
Ge
Shao-Hua
SH
Ding
Guang-Yao
GY
D000328:Adult; D000900:Anti-Bacterial Agents; D055113:Chronic Periodontitis; D003774:Dental Plaque Index; D012534:Dental Scaling; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D010514:Periodontal Pocket; D010518:Periodontitis; D016745:Root Planing
D000900:Anti-Bacterial Agents; D008911:Minocycline