Decrease of intraocular pressure after fat-removal orbital decompression in Graves disease.
OBJECTIVE
To address the efficacy of fat-removal orbital decompression to reduce intraocular pressure in patients with Graves disease.


METHODS
This cohort study included 64 eyes of 39 patients with Graves disease. Thirteen men and 36 women, with a mean age of 52.5 years (range, 27 to 80 years), underwent fat-removal orbital decompression. Intraocular pressure (applanation) and proptosis (Hertel exophthalmometry) were prospectively investigated before surgery and 1 week and 6 months after surgery.


RESULTS
The volume of resected fat was 6.4+/- 4.5 (3 to 12) ml. The intraocular pressure in primary position decreased from 19.3+/- 4.4 mm Hg to 17.0+/- 2.9 mm Hg at 1 week (p<0.001) and 15.9+/- 3.7 mm Hg at 6 months (p<0.001). Mean proptosis dropped from 24.3+/- 2.5 mm before surgery to 19.9+/-3.0 mm at 1 week (p<0.01), and 19.9+/-3.1 mm at 6 months (p<0.01). Intraocular pressure decrease neither correlated to the volume of resected fat nor to proptosis reduction.


CONCLUSIONS
Fat removal reduces intraocular pressure in patients with Graves disease, with no correlation to the volume of resected fat.
Department of Ophthalmology, CHU Dupuytren, Limoges Cedex, France.
Pierre-Yves R
PY
Robert
Mauro
M
Rivas
Philippe
P
Camezind
Jean-Yves
JY
Rulfi
Jean-Paul
JP
Adenis
D000273:Adipose Tissue / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019299:Decompression, Surgical / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome