Two new alkaloidal taxoids from the needles of Taxus canadensis.
Two new taxanes with a dimethylamino group on the C-5 side chain were identified for the first time in the needles of the Canadian yew, Taxus canadensis. Their structures were characterized as 7beta,10beta,13alpha-triacetoxy-5alpha-(3'-dimethylamino-3'-phenylpropanoyl)oxy-2alpha-hydroxy-2(3-->20)abeotaxa-4(20),11-dien-9-one (1) and 2alpha,10beta-diacetoxy-9alpha-hydroxy-5alpha-(3'-dimethylamino-3'-phenylpropanoyl)oxy-3,11-cyclotax-4(20)-en-13-one (2).
Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, P.R.China. shiqingwen@hebmu.edu.cn
Qing-Wen
QW
Shi
Xiao-Tang
XT
Si
Yong-Ming
YM
Zhao
Xiao-Hui
XH
Su
Xing
X
Li
Lolita O
LO
Zamir
Teiko
T
Yamada
Hiromasa
H
Kiyota
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D043823:Taxoids / Q000737:chemistry* / Q000302:isolation & purification*; D020946:Taxus / Q000737:chemistry*
D000470:Alkaloids; D043823:Taxoids