The effects of glucocorticoids on feeding behavior in rats.
Glucocorticoids have major effects on food intake, however, the underlying mechanisms are poorly understood. This article highlights data on the changes that occur when glucocorticoids are removed by adrenalectomy, and the effects of central and systemic administered glucocorticoids on feeding behavior in rats. Next, animal data on the interaction of glucocorticoids with insulin on intake of comfort foods are addressed and the hypothesis that glucocorticoids modify feeding behavior, whereas insulin modifies the choice of food is discussed. Finally a view is presented that hormonal and vagal signals generated when (comfort) food is consumed will affect the corticotropin-releasing factor (CRF) brain network important for the response to stress and the regulation of feeding. With a society, where stress is experienced daily and comfort food is found at every street corner, it will be vital to understand the interactions between the systems that react to stress and regulate feeding behavior to fight the obesity epidemic.
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 GC Utrecht, The Netherlands. s.e.lafleur@med.uu.nl
Susanne E
SE
la Fleur
D000315:Adrenalectomy / Q000379:methods; D000818:Animals; D001522:Behavior, Animal; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D051381:Rats; D014630:Vagus Nerve / Q000502:physiology
D005938:Glucocorticoids; D003346:Corticotropin-Releasing Hormone