[Chronic renal failure and growth hormone: effects on GH-IGF axis and leptin].
OBJECTIVE
To analyze the changes in IGF-1, IGFBP-3, leptin and insulin after replacement doses of recombinant human growth hormone (rhGH) in short prepubertal children with chronic renal failure (CRF).


METHODS
Eleven children (3F:8M), with mean age of 9.6 years, were treated with rhGH (0.23 mg/Kg weekly for 12 months). Serum leptin, insulin, glucose, IGF-1 and IGFBP-3 were measured before, 6 and 12 months after beginning rhGH treatment.


RESULTS
The serum levels of leptin, insulin and glucose did not vary during the treatment; normal leptin and glucose levels and high insulin were observed. There was a significant increment of IGF-1 and IGFBP-3 during the use of rhGH.


CONCLUSIONS
The replacement doses of rhGH during 12 months in a selected group of CRF children determined an increment in IGF-1 and IGFBP-3, associated to normal serum leptin and insulin resistance.
Oliveira
Josenilson C de
JC
Laboratório de Crescimento e Composição Corporal, Centro de Investigação em Pediatria, FCM-UNICAMP, Campinas, SP.
Machado Neto
Francisco de A
Fde A
Morcillo
André Moreno
AM
Oliveira
Laurione C de
LC
Belangero
Vera Maria S
VM
Geloneze Neto
Bruno
B
Tambascia
Marcos Antonio
MA
Guerra-Júnior
Gil
G
D001823:Body Composition; D001827:Body Height / Q000187:drug effects / Q000502:physiology; D002648:Child; D017097:Electric Impedance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D020738:Leptin / Q000097:blood*; D008297:Male; D018709:Statistics, Nonparametric; D013997:Time Factors
D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I