[Lipid profile and anthropometrical evaluation in type 1 diabetes].
Intensive insulin therapy in patients with type 1 diabetes is resulting in a better clinic and metabolic control. On the other hand, an increase in overweight and obesity prevalence, which could contribute to a higher risk of cardiovascular disease, has been observed. The aim of our study is to analyze the demographics, clinical and laboratorial factors associated to the presence of dyslipidemia in a group of patients with type 1 diabetes compared to a non-diabetic population. We have studied 72 type 1 diabetics: 52.8% female, aged 22.7 +/- 9.6 years old, with a body mass index (BMI) of 21.1 +/- 3.1 Kg/m2 and 66 non-diabetic patients: 60.6% female, aged 23.1 +/- 10.9 years old and a BMI of 22.12 +/- 3.7 Kg/m2. The group included 13 children (6 with type 1 diabetes), 47 adolescents (23 with type 1 diabetes) and 78 adults (43 with type 1 diabetes). We have found in the adult population with type 1 diabetes a lower overweight prevalence and lower levels of apoB (p< 0.01) and a higher apoA/apoB ratio (p< 0.01) when compared to the non-diabetic population. We have not found difference in the lipid profile in adult groups. Diabetic children and adolescents had higher frequency of total cholesterol (p= 0.02 and p< 0.01, respectively) and LDL-cholesterol (p= 0.02 and p= 0.01 respectively) above the upper limit when compared to the non-diabetic group. We concluded that the conventional methods for detecting lipids alterations in outpatients with type 1 diabetes under routine care are not sufficient to identify the lipid alterations, which could be related to the higher risk of cardiovascular disease in adult population.
Arcanjo
Christiane Lopes
CL
Serviço de Diabetes e Metabologia, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, RJ. christianearcanjo@terra.com.br
Piccirillo
Laura Jabour
LJ
Machado
Iara do Vale
IV
Andrade
Carlos R M de
CR
Clemente
Eliete Leão
EL
Gomes
Marília de Brito
MB
D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001053:Apolipoproteins / Q000378:metabolism; D050218:Body Fat Distribution; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002784:Cholesterol / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000401:mortality / Q000503:physiopathology; D050171:Dyslipidemias / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000502:physiology
D001053:Apolipoproteins; D002784:Cholesterol