Bronchial infiltration with diffuse large B-cell lymphoma.
Non-Hodgkin's lymphoma (NHL) refers to a heterogeneous group of lymphoproliferative diseases with a diversity of clinical courses, including involvement in another organs. NHL frequently involves the thoracic structures, and particularly the mediastinum and lung parenchyma. Several clinical reports have described bronchial-associated lymphoid tissue (BALT) lymphoma as an endobronchial lesion, but endobronchial infiltration with diffuse large B-cell lymphoma is extremely rare. Here, we provide the first report of this condition confirmed by a histopathological study and the presence of an immunoglobulin heavy chain (IgH) gene rearrangement detected by a polymerase chain reaction (PCR).
First Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka, Japan. in1211@poh.osaka-med.ac.jp
Satoshi
S
Hara
Taiji
T
Yokote
Satoko
S
Oka
Toshikazu
T
Akioka
Kichinosuke
K
Kobayashi
Motomu
M
Tsuji
Toshiaki
T
Hanafusa
D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001483:Base Sequence; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D016190:Carboplatin / Q000008:administration & dosage; D017931:DNA Primers; D005047:Etoposide / Q000008:administration & dosage; D015321:Gene Rearrangement; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000069283:Rituximab; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D017931:DNA Primers; D007143:Immunoglobulin Heavy Chains; D000069283:Rituximab; D005047:Etoposide; D016190:Carboplatin; D007069:Ifosfamide