[Influence of alcohol consumption on effectiveness of antihypertensive in male patients with essential hypertension].
OBJECTIVE
To explore the influence of alcohol consumption during ACEI (Benazepril) therapy on effectiveness of antihypertensive in male patients with essential hypertension.


METHODS
A prospective cohort study was made and multiple linear regression and multiple logistic regression models were applied to data analysis.


RESULTS
After 15 days ACEI therapy, the decrease in systolic blood pressure (deltaSBP) and diastolic blood pressure (deltaDBP) in alcohol-drinking groups was clearly smaller than that of non-drinking group. An inverse dose-response relation between alcohol drinking and (deltaSBP) as well as (deltaDBP) was observed either. To the non-alcohol-drinking group, subjects with alcohol-drinking more than 50 ml per day showed 5.26 mmHg (0.70 kPa) (P = 0.0116) and 3.32 mmHg (0.44kPa) (P = 0.0349) decreased in NSBP and DDBP, respectively. Logistic regression analysis demonstrated that the alcohol-drinking group's effect rate of antihypertensive were 45% lower (P = 0.0493) in SBP drop and 76% lower (P = 0.4750) in DBP drop respectively compared with non-and alcohol-drinking groups.


CONCLUSIONS
Alcohol drinking during ACEI therapy can lower the effectiveness of antihypertensive in male patients with essential hypertension.
Health Inspection Center of Shanghai Municipal Bureau of Health, Shanghai 200031, China.
Shao-jie
SJ
Peng
Yong-tang
YT
Jin
Dong
D
Li
Ai-qun
AQ
Huang
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001552:Benzazepines / Q000627:therapeutic use*; D002681:China; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D001552:Benzazepines; C044946:benazepril