Brain maturation in conduct disorder versus borderline personality disorder.
Conduct disorder (CD) and borderline personality disorder (BPD) have been associated with abnormalities in brain function. The present study assessed whether adolescents with significant symptoms of CD and BPD display abnormal brain maturation. Participants recruited from the community were categorized as CD only, BPD only, CD plus BPD, or controls with neither CD nor BPD. Brain maturation was estimated by the amplitude difference in the P300 event-related brain potential between participants < versus > or = 17 years old. With increasing age, controls and BPD only participants exhibited a P300 amplitude decline. This pattern was not evident in the CD only and CD plus BPD groups. The different brain maturation patterns seen in adolescents with CD versus BPD symptoms may contribute to differences in age-of-onset, clinical course, and resistance to treatment.
Ceballos
Natalie A
NA
Department of Behavioral Sciences, University of Minnesota Medical School Duluth, Duluth, Minn. 55812, USA. nceballo@d.umn.edu
Houston
Rebecca J
RJ
Hesselbrock
Victor M
VM
Bauer
Lance O
LO
D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000987:Antisocial Personality Disorder / Q000503:physiopathology; D001883:Borderline Personality Disorder / Q000503:physiopathology*; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D019955:Conduct Disorder / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D012016:Reference Values; D018709:Statistics, Nonparametric