Effects of human interleukin 7 on HIV-1 replication in monocyte-derived human macrophages.
Interleukin 7 (IL-7) contributes to development and proliferation of T cells. We investigated the effect of IL-7 on HIV-1 infected monocyte-derived human macrophages. IL-7 treatment of macrophages at a concentration of 10 ng/ml reduced replication of the R5 HIV-1 strain by approximately 50%. Meanwhile, HIV-1-infected macrophages themselves could excrete approximately 20% more IL-7 than uninfected macrophages. These results suggest that IL-7 could be used as a therapeutic modality to recover CD4 T cells.
Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Haihan
H
Song
Emi E
EE
Nakayama
Tatsuo
T
Shioda
D002454:Cell Differentiation; D002478:Cells, Cultured; D015870:Gene Expression; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015851:Interleukin-7 / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology / Q000821:virology*; D009000:Monocytes / Q000166:cytology; D012333:RNA, Messenger / Q000235:genetics; D020395:Receptors, Interleukin-7 / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects*
D015851:Interleukin-7; D012333:RNA, Messenger; D020395:Receptors, Interleukin-7