Dietary comparison of conjugated linolenic acid (9 cis, 11 trans, 13 trans) and alpha-tocopherol effects on blood lipids and lipid peroxidation in alloxan-induced diabetes mellitus in rats.
The present study investigated the dietary effect of conjugated linolenic acid (CLnA) on lipid profiles and lipid peroxidations in alloxan-induced diabetes mellitus in rats. Diabetic rats were fed with 20% sunflower oil (diabetic control), sunflower oil supplemented with 0.5% CLnA, sunflower oil supplemented with 0.15% alpha-tocopherol, and sunflower oil containing 0.25% CLnA + 0.15% alpha-tocopherol. The results demonstrated that 0.5% CLnA, 0.15% alpha-tocopherol, and 0.25% CLnA + 0.15% alpha-tocopherol each on supplementation significantly lowered total cholesterol and non-HDL-cholesterol in comparison with the diabetic control group. The TAG level was significantly lowered in both the 0.15% alpha-tocopherol and 0.25% CLnA + 0.15% alpha-tocopherol groups. LDL-lipid peroxidation and erythrocyte membrane lipid peroxidation were reduced significantly in each of the experimental groups vs. the control group. The CLnA + alpha-tocopherol diet induced a greater reduction in membrane lipid and liver lipid peroxidation than the alpha-tocopherol diet alone. In conclusion, dietary CLnA exerts antioxidant activity as evidenced by reduced lipid peroxidation in chemically induced diabetes mellitus.
Dhar
P
P
Department of Physiology, Krishnagar Government College, Calcutta University, Kolkata-700 009, India.
Bhattacharyya
D
D
Bhattacharyya
D K
DK
Ghosh
S
S
D000496:Alloxan; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004032:Diet; D004910:Erythrocyte Membrane / Q000378:metabolism; D008042:Linolenic Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D024502:alpha-Tocopherol / Q000494:pharmacology*
D008042:Linolenic Acids; D008055:Lipids; D000496:Alloxan; D024502:alpha-Tocopherol