Biocompatibility of glass-ionomer bone cements.
Glass-ionomer cements (GIC) have been extensively used in dentistry for over 30 years. Due to their excellent biocompatibility in dental applications GIC have been formulated for medical applications. The past decade has seen some impressive advances in the development of medical GICs, however these advances have been matched by serious critical problems. This review examines the properties of GICs, which can influence their behaviour in a biological environment. The progress made and the problems encountered in the development of these bone cements will also be addressed. The review will conclude with the research currently being employed to optimise the biocompatibility of these important biomaterials. There is little doubt that GICs compare favourably with alternative bone cements for specific applications, based on in vitro and in vivo studies. There is however, a degree of risk inherent in the use of any medical device or biomaterial. GICs must therefore be used carefully and in accordance with the instructions that are based on a significant body of research data.
Centre for Biomaterials & Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK. p.v.hatton@sheffield.ac.uk
P V
PV
Hatton
K
K
Hurrell-Gillingham
I M
IM
Brook
D000535:Aluminum / Q000633:toxicity; D000818:Animals; D001178:Arthroplasty; D001843:Bone Cements / Q000633:toxicity*; D001861:Bone Regeneration / Q000187:drug effects; D005899:Glass Ionomer Cements / Q000633:toxicity*; D006801:Humans; D008422:Materials Testing
D001843:Bone Cements; D005899:Glass Ionomer Cements; D000535:Aluminum