BRCA1-positive breast cancers in young women from Poland.
We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.
Lubiński
J
J
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Połabska 4, 70-115 Szczecin, Poland. lubinski@sci.pam.szczecin.pl
Górski
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Huzarski
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Byrski
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Gronwald
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Serrano-Fernández
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Domagała
W
W
Chosia
M
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Uciński
M
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Grzybowska
E
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Lange
D
D
Maka
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B
Mackiewicz
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A
Karczewska
A
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Breborowicz
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Lamperska
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Stawicka
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Gozdecka-Grodecka
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Bebenek
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Sorokin
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D
Wojnar
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Haus
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Sir
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Mierzwa
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Niepsuj
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Gugała
K
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Góźdź
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Sygut
J
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Kozak-Klonowska
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B
Musiatowicz
B
B
Posmyk
M
M
Kordek
R
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Morawiec
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M
Zambrano
O
O
Waśko
B
B
Fudali
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Skret
J
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Surdyka
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Urbański
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K
Mituś
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Ryś
J
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Szwiec
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Rozmiarek
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Dziuba
I
I
Wandzel
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P
Wiśniowski
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R
Szczylik
C
C
Kozak
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A
Kozłowski
W
W
Narod
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D000328:Adult; D019313:BRCA1 Protein / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D015233:Models, Statistical; D009154:Mutation; D011044:Poland; D011446:Prospective Studies
D019313:BRCA1 Protein