Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration.
A 51 year old man with paraneoplastic cerebellar degeneration from gastric adenocarcinoma showed cerebellar hypermetabolism and increased perfusion on brain FDG-PET scan and SPECT during the acute stage of his illness. The patient underwent subtotal gastrectomy. The intensity of the hypermetabolism had decreased markedly on follow-up FDG-PET 3 months later following two cycles of chemotherapy. We suggest that the cerebellar hypermetabolism may have been due to an acute inflammatory process associated with an immunological reaction.
Choi
K-D
KD
Department of Neurology, College of Medicine, Seoul National University, Republic of Korea.
Kim
J S
JS
Park
S-H
SH
Kim
Y K
YK
Kim
S E
SE
Smitt
P S
PS
D002528:Cerebellar Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002531:Cerebellum / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18