Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice.
We observed that curry leaf (Murraya koenigii) extract possesses the property to decrease blood cholesterol and blood glucose levels in diabetic ob/ob mice. Mice received daily intraperitoneal injections of 80 mg/kg curry leaf extract for 10 consecutive days. The extract significantly decreased blood cholesterol level from 277.6 +/- 16.6 mg/d (day 0) to 182.0 +/- 15.3 mg/d (day 10, p < 0.01 compared with the change in vehicle group). The extract also significantly decreased blood glucose level from 387.0 +/- 15.6 mg/dl (day 0) to 214.0 +/- 26.6 mg/dl (day 10, p < 0.01). In addition, body weight was reduced after extract treatment. Our data suggest that curry leaf may be proved to be of clinical importance in improving the management of high cholesterol level and type 2 diabetes.
Xie
Jing-Tian
JT
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL 60637, USA.
Chang
Wei-Tien
WT
Wang
Chong-Zhi
CZ
Mehendale
Sangeeta R
SR
Li
Jing
J
Ambihaipahar
Ramalingam
R
Ambihaipahar
Umadevi
U
Fong
Harry H
HH
Yuan
Chun-Su
CS
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D051379:Mice; D032101:Murraya / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
D001786:Blood Glucose; D002784:Cholesterol