14-3-3 proteins: do they have a role in human cancer?
The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.
University of Arizona, Arizona Cancer Center and Department of Cell Biology & Anatomy, Tucson, AZ 85724, USA. jmartinez@azcc.arizona.edu
Jesse D
JD
Martinez
D048948:14-3-3 Proteins / Q000378:metabolism*; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
D048948:14-3-3 Proteins