CDK control of membrane-bound organelle homeostasis.
In eukaryotes, the copy number and size of any given organelle compartment remain constant in dividing cells, underlying a tight coordination between cell division and organelle homeostasis. However, in most cases the mechanisms for this coordination remain mysterious. Here we outline a few cases where the cell cycle machinery directly impacts on organelle homeostasis, with emphasis on the control of vacuolar (lysosomal) copy number and size in budding yeast. We also discuss aspects of organelle biology that can profoundly affect certain cell cycle parameters, such as cell size.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.
Heidi M
HM
Blank
James M
JM
Totten
Michael
M
Polymenis
D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006706:Homeostasis; D007425:Intracellular Membranes / Q000378:metabolism*; D008561:Membrane Fusion; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism
D018844:Cyclin-Dependent Kinases