Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes.
A 58-year-old man concurrently developed polymyositis (PM), interstitial lung disease, and nephrotic-range proteinuria. Renal biopsy revealed focal mesangial proliferative glomerulonephritis (mesPGN) with depositions of immunoglobulin and complements. A combination therapy of corticosteroid, intravenous immunoglobulin, and cyclosporine was found very effective for the patient. Glomerulonephritis associated with PM/dermatomyositis (DM) is rare. In our review of related literature, mesPGN was exclusively observed in polymyositis while membranous nephropathy in DM. The mechanism underlying the association between myositis and glomerulonephritis remains to be elucidated.
Takizawa
Yasunobu
Y
Department of Allergy and Rheumatology, University of Tokyo, 7-3-1 Hongo, Tokyo, 113-8655, Japan.
Kanda
Hiroko
H
Sato
Kojiro
K
Kawahata
Kimito
K
Yamaguchi
Akihiro
A
Uozaki
Hiroshi
H
Shimizu
Jun
J
Tsuji
Shoji
S
Misaki
Yoshikata
Y
Yamamoto
Kazuhiko
K
D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000150:complications*