Endothelium-independent relaxation of aorta rings by two stilbenoids from the orchids Scaphyglottis livida.
Gigantol (1) and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2) from the orchid Scaphyglottis livida induced a significant concentration-dependent relaxation of the contractions evoked by noradrenaline (NA) in endothelium-intact and denuded rat aorta rings. Incubation with N(G)-nitro-L-arginine methyl ester (L-NAME, 1x10(-5) M) or methylene blue (MB, 1x10(-7) M) significantly reduced the relaxation induced by the stilbenoids 1 and 2. The results suggested that two or more mechanisms are involved in the vasorelaxant effects of both compounds.
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México, D. F., 04510, México.
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Estrada-Soto
J J
JJ
López-Guerrero
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Villalobos-Molina
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Mata
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001632:Bibenzyls; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008519:Medicine, Traditional; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
C511111:3,7-dihydroxy-2,4-dimethoxyphenanthrene; D001632:Bibenzyls; D010616:Phenanthrenes; D013267:Stilbenes; D014665:Vasodilator Agents; C478099:gigantol; D006139:Guaiacol; D012964:Sodium