Lipodystrophy is an independent predictor of hypertriglyceridemia during pregnancy in HIV-infected women.
Lipid values were measured during pregnancy in HIV-infected, treatment-experienced women. A previous history of lipodystrophy was associated with significantly higher triglyceride values at all pregnancy trimesters. In multivariate analyses lipodystrophy independently increased the risk of hypertriglyceridemia by threefold at the first trimester, and by eightfold at the second and third trimesters. Protease inhibitor treatment was also independently associated with hypertriglyceridemia.
Floridia
Marco
M
Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Rome.
Guaraldi
Giovanni
G
Tamburrini
Enrica
E
Tibaldi
Cecilia
C
Bucceri
Anna
A
Anzidei
Gianfranco
G
Meloni
Alessandra
A
Vimercati
Antonella
A
Polizzi
Cosimo
C
Dalle Nogare
Ernesto Renato
ER
Alberico
Salvatore
S
Ravizza
Marina
M
D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D017320:HIV Protease Inhibitors; D014280:Triglycerides; D002784:Cholesterol