Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.
Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
CMM (Infectious Diseases), St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom.
Catherine A
CA
Cosgrove
Luiz R R
LR
Castello-Branco
Tracy
T
Hussell
Amy
A
Sexton
Rafaela
R
Giemza
Richard
R
Phillips
Andrew
A
Williams
George E
GE
Griffin
Gordon
G
Dougan
David J M
DJ
Lewis
D000284:Administration, Oral; D000328:Adult; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007117:Immunization, Secondary; D007271:Injections, Intradermal; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology*
D016207:Cytokines; D014373:Tuberculin; D032581:Tuberculosis Vaccines