Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma.
Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases. This study investigates eight polymorphisms across the NFKBIA gene in large patient and control populations. Significant differences in the frequency of particular polymorphisms were noted between patients and controls. A risk haplotype [GCCTATCA] for MM was also identified (P=0.006). Analysis of the genetics of NFKBIA may lead to associations with disease progression and survival and thus more personalized therapy.
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, UK. sciencecharlotte@yahoo.co.uk
Charlotte F
CF
Spink
Lisa C
LC
Gray
Faith E
FE
Davies
Gareth J
GJ
Morgan
Jeffrey L
JL
Bidwell
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D009101:Multiple Myeloma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid
C083487:I kappa B beta protein; D020672:I-kappa B Proteins