Incidental mononuclear cell infiltrate in the uvea of cynomolgus monkeys.
Mononuclear cell infiltrate (MCI) in the uvea was observed in naïve, untreated (control group) cynomolgus monkeys in approximately 25% of drug safety evaluation studies. The total incidence of MCI in the choroid and the ciliary body was 29% of 342 males and 25% of 306 female monkeys. In the studies in which MCI was present in the ciliary body or choroid, the incidence was as high as 75%. There were no other ocular histopathologic findings in these monkeys. All monkeys were clinically healthy and the eyes were not remarkable when examined ophthalmoscopically.
Sinha
Dinesh P
DP
Department of Drug Safety and Metabolism, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA. dineshwar.sinha@spcorp.com
Cartwright
Mark E
ME
Johnson
Robert C
RC
D000818:Animals; D002829:Choroid / Q000473:pathology; D002924:Ciliary Body / Q000473:pathology; D005260:Female; D007498:Iris / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D018675:Toxicity Tests; D014602:Uvea / Q000473:pathology*; D014605:Uveitis / Q000473:pathology / Q000662:veterinary*