Recurrent mesenchymal hamartoma associated with 19q translocation. A call for more radical surgical resection.
Hepatic mesenchymal hamartoma is a rare benign tumour in children. It is often large and centrally located in the liver at diagnosis, making surgical resection difficult; thus non-radical resection has been proposed in the past as acceptable management. However, a literature survey and a case with recurrence associated with cytogenetic anomalies suggest that radical liver surgery (resection with a margin of normal liver parenchyma, as for malignant tumour) should be recommended for mesenchymal hamartoma.
Liver Unit, Birmingham Children's Hospital, Birmingham, UK.
K
K
Sharif
P
P
Ramani
H
H
Lochbühler
R
R
Grundy
J
J
de Ville de Goyet
D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D006222:Hamartoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008648:Mesoderm / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic