Cavitands with revolving doors regulate binding selectivities and rates in water.
A water-soluble self-folding cavitand has been prepared, featuring four benzoate groups attached to the open end. These benzoates act as rapidly "revolving doors" to the cavity. The cavitand shows increased selectivity for small hydrophobic guests and slower rates of guest exchange.
Hooley
Richard J
RJ
The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute MB-26, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Van Anda
Hillary J
HJ
Rebek
Julius
J
D004988:Ethers, Cyclic / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012118:Resorcinols / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D004988:Ethers, Cyclic; D012118:Resorcinols; C442939:cavitand; D014867:Water