Bronchopulmonary dysplasia: incidence, risk factors and resource utilization in a population of South American very low birth weight infants.
OBJECTIVE
To determine the incidence of bronchopulmonary dysplasia, its risk factors and resource utilization in a large South American population of very low birth weight infants.


METHODS
Prospectively collected data in infants weighing 500 to 1,500 g born at 16 NEOCOSUR Network centers from 10/2000 through 12/2003. Multivariate relative risk and 95% confidence intervals were estimated by Poisson regression with robust error variance to find factors that affected the risk of bronchopulmonary dysplasia.


RESULTS
1,825 very low birth weight infants survivors were analyzed. Mean birth weight and gestational age were 1085+/-279 g and 29+/-3 weeks respectively. Bronchopulmonary dysplasia incidence averaged 24.4% and survival without bronchopulmonary dysplasia augmented with increasing gestational age. A higher birth weight and gestational age and a female gender all decreased the risk for bronchopulmonary dysplasia. Factors that independently increased that risk were surfactant requirement, mechanical ventilation, airleak, patent ductus arteriosus, late onset sepsis and necrotizing enterocolitis. Bronchopulmonary dysplasia infants had more days of hospitalization (91+/-27 vs. 51+/-19), of mechanical ventilation (19+/-20 vs. 4+/-7) and oxygen therapy (72+/-30 vs. 8+/-14) in comparison with non BPD infants.


CONCLUSIONS
Bronchopulmonary dysplasia incidence was 24.4% in a large South American population and is related to greater resource utilization. Risk factors for bronchopulmonary dysplasia in this study were: surfactant requirement, mechanical ventilation, airleak, patent ductus arteriosus, late onset sepsis and necrotizing enterocolitis. These studies may provide useful information in the design of effective preventive perinatal strategies.
Departamento de Pediatría, Pontificia Universidad Católica de Chile, Santiago, Chile. jlta@med.puc.cl
Jose L
JL
Tapia
Daniel
D
Agost
Angelica
A
Alegria
Jane
J
Standen
Marisol
M
Escobar
Carlos
C
Grandi
Gabriel
G
Musante
Jaime
J
Zegarra
Alberto
A
Estay
Rodrigo
R
Ramírez
D001034:Apgar Score; D001835:Body Weight; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000628:therapy; D004812:Epidemiologic Methods; D005260:Female; D005865:Gestational Age; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D008297:Male; D013020:South America / Q000453:epidemiology; D013997:Time Factors