Protective effect of a synthetic polynucleotide complex (poly I: C) on ocular lesions produced by trachoma agent in rabbits.
Live trachoma agent (TE55) injected into the anterior chamber of the rabbit eye produced the following agent-specific ocular lesions: corneal opacity, corneal neovascularization, and iritis. Three intravenous injections of 1 mg of a potent interferon (IF) inducer, polyriboinosinic acid-polyribocytidylic acid complex (poly I:C), markedly suppressed the ocular lesions produced by the trachoma agent but failed to inhibit the growth of the agent in the ocular tissues. Furthermore, a single intravenous injection of 1 mg of polyriboinosinic acid or of polyribocytidylic acid was also protective, although each failed to induce any detectable circulating IF. These results indicate that a factor or factors other than IF may play a role in the suppression of the ocular lesions produced by trachoma agent in poly I:C-injected rabbits.
Francis I. Proctor Foundation and George Williams Hooper Foundation, University of California Medical Center, San Francisco, California 94122.
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