Meningocele and ankyloblepharon following in utero exposure to olanzapine.
Although atypical antipsychotics are widely used during pregnancy, their safety is not well established. This case highlights the possible teratogenic effect of olanzapine, in which the baby was born with meningocele and ankyloblepharon. It is suggested that olanzapine may interfere with embryonic development at different stages of pregnancy.
Central Institute of Psychiatry, Knake, Jharkhand, India. drmanu2004@rediffmail.com
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Arora
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Praharaj
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D019052:Depression, Postpartum / Q000188:drug therapy*; D005143:Eyelids / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008588:Meningocele / Q000139:chemically induced*; D000077152:Olanzapine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D011297:Prenatal Exposure Delayed Effects; D012008:Recurrence
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine