An overview of the genetics of substance use disorders.
Twin, family, and adoption studies show that genetic factors play a significant role in vulnerability to becoming addicted to drugs. Through a combination of genetic approaches, the variant alleles responsible for interindividual differences in susceptibility to addiction are being uncovered.
Lachman
H M
HM
Albert Einstein College of Medicine, Departments of Medicine and Psychiatry, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Lachman@aecom.yu.edu
D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D009714:Nucleus Accumbens / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000235:genetics / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000235:genetics* / Q000378:metabolism
C485764:OPRM1 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D017450:Receptors, Opioid, mu; D002394:Catechol O-Methyltransferase; D004298:Dopamine