[Pharmacokinetics study on yinhuang compound microenema in rabbits].
OBJECTIVE
To determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema.


METHODS
HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema.


RESULTS
Baicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.311 h, t(1/2)beta of 1.640 h, AUC of 1.531 x 10(-2) g x h x L(-1), tmax of 0.287 h, Vd of 2.182 L. Chlorogenic acid showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.324 h, t(1/2)beta of 1.206 h, AUC of 2.135 x 10(-2) g x h x L(-1), tmax of 0.317 h,Vd of 2.251 L.


CONCLUSIONS
The main components in Yinhuang compound microenema baicalin and chlorogenic acid are absorbed quickly and absolutely after rectal administration, which have good characters of pharmacokinetics.
Department of Pharmacology, Guangxi Medical University, Nanning, China.
San-hai
SH
Qin
Hua-gan
HG
Liu
D000818:Animals; D019540:Area Under Curve; D029972:Bupleurum / Q000737:chemistry; D002726:Chlorogenic Acid / Q000097:blood*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004733:Enema; D005260:Female; D005419:Flavonoids / Q000097:blood*; D031239:Lonicera / Q000737:chemistry; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D002726:Chlorogenic Acid; C038044:baicalin