Self-reported paranoia during laboratory "binge" cocaine self-administration in humans.
Cocaine-induced paranoia (CIP) has been extensively studied by retrospective interviews; however, only limited efforts have been made to further characterize CIP by human laboratory methods. We examined CIP in 28 healthy cocaine-dependent volunteers, who participated in 2-h, intravenous cocaine self-administration sessions at 8, 16, and 32 mg/70 kg doses, including 18 in a placebo-controlled design. Self-reports of paranoia showed significant main effects of cocaine dose (p=0.0002) and time (p=0.0003), and were statistically distinguishable from placebo at the two highest doses (16 and 32 mg). These effects were accounted for by a subgroup of vulnerable subjects in whom self-reports were consistent across dose and test-retest sessions. Subjects with CIP did not differ from those without CIP with respect to demographic, cocaine use, or cocaine self-administration variables. In conclusion, self-reports of CIP in the human lab are frequently endorsed, dose-dependent, and though variable between subjects, reproducible within subjects. Such methods may facilitate our understanding of the vulnerability to CIP in humans.
Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA.
Rasmon
R
Kalayasiri
Atapol
A
Sughondhabirom
Ralitza
R
Gueorguieva
Vladimir
V
Coric
Wendy J
WJ
Lynch
Peter T
PT
Morgan
Joseph F
JF
Cubells
Robert T
RT
Malison
D000293:Adolescent; D000328:Adult; D003042:Cocaine / Q000008:administration & dosage*; D006801:Humans; D007276:Injections, Intraventricular; D008875:Middle Aged; D009042:Motivation; D010147:Pain Measurement; D010259:Paranoid Disorders / Q000139:chemically induced*; D010919:Placebos; D012646:Self Administration; D012647:Self-Assessment
D010919:Placebos; D003042:Cocaine