[The influence of mononucleosis infection on atopic disease development in children].
The aim of the study was to determine whether infectious mononucleosis may trigger atopic symptoms or modulate their clinical course. Data from literature point out to such a relationship and attribute it to the influence of EBV on lymphocytes B and IL-4,IL-5,IL-10 and vIL-10 secretion stimulation. The authors examined 30 children who had suffered from symptomatic infectious mononucleosis 2-4 years previously, evaluating symptoms of allergic diseases and performing skin prick tests with selected inhalant and food allergens. The symptoms of atopic disease were found in 57 % in the mononucleosis group, a significantly higher percentage (p<0.0001) than in general population of children in Lódź (16%). The frequency of positive skin prick tests with common allergens was also significantly higher (60% vs 27%, respectively).
Klinika Propedeutyki Pediatrii i Chorób Metabolicznych Kości Uniwersytetu Medycznego w Lodzi.
Anna
A
Stańczyk-Przyłuska
Anna
A
Szmidt
Piotr
P
Kuna
Izabela
I
Kupryś-Lipińska
Anna
A
Wolska
D000293:Adolescent; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D015897:Comorbidity; D003876:Dermatitis, Atopic / Q000175:diagnosis; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000453:epidemiology*; D007244:Infectious Mononucleosis / Q000453:epidemiology*; D008297:Male; D011044:Poland / Q000453:epidemiology; D012130:Respiratory Hypersensitivity / Q000175:diagnosis; D012882:Skin Tests / Q000706:statistics & numerical data