[Clinical features and treatment of hepatic tumor-like lesions].
OBJECTIVE
Focal nodular hyperplasia (FNH), inflammatory pseudotumor (IPT), adenomatous nodular hyperplasia (ANH), and focal fatty change (FFC) are common hepatic tumor-like lesions, a group of benign liver diseases, which remains difficult to be distinguished from primary liver cancer (PLC). This study was to investigate the clinical features and treatment of these 4 kinds of hepatic tumor-like lesions.


METHODS
Clinical data of 70 patients with pathologically conformed hepatic tumor-like lesions, treated in Cancer Center of Sun Yat-sen University from 1992 to 2004, were studied retrospectively.


RESULTS
Of the 70 patients, 34 (48.6%) had clinical symptoms, and most of them suffered mild pain in the abdomen; 22 (31.4%) were positive for hepatitis B virus (HBV) antigen; 21 had mild abnormal liver function; 6 had alpha fetal protein (AFP) > 25 microg/L. The ultrasonography and computed tomography (CT) presentations of the tumor-like lesions were various. Only 8 cases of FNH were diagnosed preoperatively. Sixty-one patients received resection, with no postoperative complication occurred. One case of FNH and 1 case of IPT were recurred during follow-up, and treated with non-resection therapy.


CONCLUSIONS
Hepatic tumor-like lesions are difficult to be distinguished from PLC. Exploratory operation should be performed in cases suspicious of PLC.
Guo
Rong-Ping
RP
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China. rpguo@gzsums.edu.cn
Zhong
Chong
C
Shi
Ming
M
Wei
Wei
W
Zhang
Ya-Qi
YQ
Li
Jin-Qing
JQ
Li
Guo-Hui
GH
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005234:Fatty Liver / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D020518:Focal Nodular Hyperplasia; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D006498:Hepatectomy / Q000379:methods*; D006511:Hepatitis B Antigens / Q000097:blood; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000378:metabolism
D006511:Hepatitis B Antigens; D000509:alpha-Fetoproteins