Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver.
Liver-cell adenomas are benign lesions of the liver occurring predominantly in young women. Hepatocellular carcinomas in most of the cases arise in a cirrhotic liver during the fifth or sixth decade. We describe the case of a 40-year-old woman in whom work-up for epigastric pain revealed a peptic ulcer and a large hepatic mass. Tests for chronic liver diseases were negative. Imaging findings and biopsy specimens of the tumour were inconclusive. The tumour was surgically removed and a hepatocellular carcinoma arising within a liver-cell adenoma in a non-cirrhotic liver was found. Malignant transformation of liver-cell adenoma has only been reported in a few case reports. Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed.
Department of Gastroenterology , University Hospital Liestal, Switzerland. emanuel.burri@gmx.ch
Emanuel
E
Burri
Michael
M
Steuerwald
Gieri
G
Cathomas
Gilles
G
Mentha
Pietro
P
Majno
Laura
L
Rubbia-Brandt
Rémy
R
Meier
D018248:Adenoma, Liver Cell / Q000473:pathology*; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*