Isolated heart function after ischemia and reperfusion in sucrose-fed rats: influence of gender and treatment.
Sucrose-fed rats (HTG) develop hypertension, hypertriglyceridemia, and other features of the metabolic syndrome. This condition, nowadays a world epidemic, is more prevalent in males and increases the risk of cardiovascular diseases. Weanling male and female rats were given either tap water in control (C) or 30% sucrose solution in HTG groups and commercial rat chow for 3, 5, or 8 months. We studied possible variations in cardiac function, due to gender and length of treatment, in isolated heart after ischemia-reperfusion, since an impaired performance may be more easily detected under stress. Together, sucrose treatment and age affected all cardiac variables. Gender had significant effect on coronary vascular resistance and postischemic levels of the enzyme CK-MB; the percentages of retained cardiac enzymes after ischemia were higher in C and HTG females. C and HTG males had a higher incidence of arrhythmias than females, but only HTG males suffered lethal ventricular fibrillation.
Department of Biochemistry, Instituto Nacional de Cardiologia Ignacio Chávez, Tlalpan, Mexico, DF.
Graciela
G
Cárdenas
Juan
J
Carlos Torres
José
J
Zamora
Israel
I
Pérez
Guadalupe
G
Baños
D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003331:Coronary Vessels / Q000503:physiopathology; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006973:Hypertension / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D012737:Sex Factors; D013395:Sucrose / Q000633:toxicity; D014655:Vascular Resistance / Q000502:physiology
D015415:Biomarkers; D013395:Sucrose; D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form