Botulinum toxin A relieved neuropathic pain in a case of post-herpetic neuralgia.
Botulinum toxin type A (BTX-A) has been widely used in many clinical disorders including migraine, cervical dystonia, etc. The use of BTX-A in neuropathic pain, however, is uncommon, and the application of the anti-nociceptive effect of botulinum toxin is emerging. Here we report a case of an 80-year-old man who suffered from severe pain of post-herpetic neuralgia which was refractory to the usual therapies. However, this neuropathic pain was dramatically relieved by multiple BTX-A injection and the pain relief lasted 52 days.
Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsu-Tang
HT
Liu
Shen-Kou
SK
Tsai
Ming-Chang
MC
Kao
Jenkin S
JS
Hu
D000109:Acetylcholine / Q000378:metabolism; D000369:Aged, 80 and over; D000588:Amines / Q000627:therapeutic use; D000639:Amitriptyline / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D004334:Drug Administration Schedule; D000077206:Gabapentin; D006562:Herpes Zoster / Q000150:complications*; D006801:Humans; D007279:Injections, Subcutaneous; D007367:Intercostal Nerves / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000502:physiology; D009437:Neuralgia / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009498:Neurotoxins / Q000627:therapeutic use; D009619:Nociceptors / Q000187:drug effects / Q000503:physiopathology; D012867:Skin / Q000294:innervation / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
D000588:Amines; D000700:Analgesics; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D009498:Neurotoxins; D000639:Amitriptyline; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D019274:Botulinum Toxins, Type A; D000109:Acetylcholine