Pilot-scale production of group a and group C meningococcal polysaccharide immunogens.
Methods have been developed for the pilot-scale production of group A and group C meningococcal polysaccharide immunogens based on the meningococcal strains, the medium, and the basic processing procedures used by Gotschlich et al. Physical and chemical assays on the final products obtained on a pilot-scale level indicate that these purified polysaccharides are entirely comparable to the Gotschlich preparations which proved to be immunogenic in man.
Berman
S
S
Department of Biologics Research, Walter Reed Army Institute of Research, Washington, D.C. 20012.
Altieri
P L
PL
Groffinger
A
A
Lowenthal
J P
JP