Palladium-catalyzed direct arylation of simple arenes in synthesis of biaryl molecules.
Significant progress has been made in the direct arylation of simple arenes. A number of catalyst systems have been developed which enable the intramolecular direct arylation of aryl chlorides, bromides and iodides in high yield as well as conditions capable of achieving intermolecular direct arylation with simple arenes. This account describes recent progress by our group and others in the development of these reactions.
Center for Catalysis Research and Innovation, University of Ottawa, Departement of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
Louis-Charles
LC
Campeau
Keith
K
Fagnou
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry
D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D011084:Polycyclic Aromatic Hydrocarbons; D010165:Palladium