Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cells.
BACKGROUND
A family of six cardiovascular hormones--atrial natriuretic peptide, brain natriuretic peptide, C-natriuretic peptide, long acting natriuretic peptide, vessel dilator and kaliuretic peptide--was investigated for the ability to decrease the number of human angiosarcoma cells.


RESULTS
Within 24 h, vessel dilator, long acting natriuretic peptide, kaliuretic peptide, atrial natriuretic peptide and their intracellular mediator cyclic GMP decreased the number of angiosarcoma cells by 61, 30, 29, 36 and 32%, respectively, and DNA synthesis by 68-85%. Brain natriuretic peptide and C-natriuretic peptide had no effect(s). The natriuretic peptide receptor C was present.


CONCLUSIONS
Four cardiovascular hormones decrease the number of angiosarcoma cells within 24 h via inhibition of DNA synthesis mediated in part by cyclic GMP.
Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center Tampa, FL 33612, USA.
Brian A
BA
Vesely
Abdel
A
Alli
Shijie
S
Song
Juan
J
Sanchez-Ramos
Shannon R
SR
Fitz
William R
WR
Gower
David L
DL
Vesely
D000704:Analysis of Variance; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D006394:Hemangiosarcoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology; D020098:Natriuretic Peptide, C-Type / Q000494:pharmacology; D045265:Natriuretic Peptides / Q000494:pharmacology*; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D045265:Natriuretic Peptides; D019384:Nucleic Acid Synthesis Inhibitors; D010446:Peptide Fragments; D011498:Protein Precursors; C075322:atrial natriuretic factor precursor (79-98); C054547:atrial natriuretic factor prohormone (1-30), human; C054548:atrial natriuretic factor prohormone (31-67); D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009320:Atrial Natriuretic Factor; D004247:DNA