Measles vaccination effectiveness among children under 5 years of age in Kampala, Uganda.
Measles control remains a great challenge in Uganda. We conducted a prospective study among household contacts aged 9-59 months to assess measles vaccination effectiveness. Index cases were measles patients seen in Kampala hospitals in 1999. Measles was diagnosed in 37/43 (86%) of unvaccinated and in 33/145 (23%) of vaccinated exposed contacts, respectively. Vaccination effectiveness was 74% (95% CI; 64-81), which was lower than expected. This may indicate the need for strengthening of the cold chain and/or introduction of a second opportunity for measles vaccination, either as part of the routine immunization program or in the form of supplementary immunization activities.
Mupere
Ezekiel
E
Department of Paediatrics and Child Health, Faculty of Medicine, Makerere University, Kampala, Uganda. mupez@yahoo.com
Karamagi
Charles
C
Zirembuzi
George
G
Grabowsky
Mark
M
de Swart
Rik L
RL
Nanyunja
Miriam
M
Mayanja
Harriet
H
D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008457:Measles / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D008459:Measles virus / Q000276:immunology; D011446:Prospective Studies; D014454:Uganda / Q000453:epidemiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine