Thrombogenic risk factors for atherothrombosis.
Thrombosis superimposed on a disrupted plaque is the proximate event that triggers most acute ischemic syndromes and episodes of sudden cardiac death. A significant number of acute ischemic events occur in individuals without traditional atherosclerosis-related risk factors. In an attempt to pinpoint additional risk factors, researchers are examining the thrombotic cascade and the cellular components, plasma proteins, and endothelium-derived mediators, as well as their genetic polymorphisms, that may affect this system. This article enumerates a number of potential hemostatic risk factors and discusses the evidence linking them to atherothrombotic events.
Atherosclerosis Research Center, Division of Cardiology and Department of Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Prediman K
PK
Shah
D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D003328:Coronary Thrombosis / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D005165:Factor V / Q000502:physiology; D005167:Factor VII / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D006801:Humans; D007958:Leukocyte Count; D010974:Platelet Aggregation / Q000502:physiology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018180:Thrombomodulin / Q000502:physiology
D018180:Thrombomodulin; D005165:Factor V; D005167:Factor VII; D005340:Fibrinogen