Suppression of collagen-induced arthritis by oral administration of the citrus flavonoid hesperidin.
The preventive and therapeutic effects of the Citrus flavonoid hesperidin (HES) on the development of collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), were investigated. Mice were administered orally HES three times a week starting from either the onset (day 21) of secondary immunization or on day 31, when the CIA development had reached a plateau. In both cases, treatment with HES resulted in a significant suppression of clinical scores and improvement of histological features. These results suggest that oral administration of HES could be effective for treating human RA patients.
Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University, Sagamihara, Japan.
Kiichiro
K
Kawaguchi
Hiroko
H
Maruyama
Takashi
T
Kometani
Yoshio
Y
Kumazawa
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000188:drug therapy*; D002957:Citrus; D003094:Collagen; D004195:Disease Models, Animal; D015536:Down-Regulation; D006569:Hesperidin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007719:Knee Joint / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012333:RNA, Messenger / Q000032:analysis; D013047:Specific Pathogen-Free Organisms; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000235:genetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D003094:Collagen; D006569:Hesperidin