[The apoptosis marker enzyme poly-(ADP-ribose) polymerase (PARP) in systemic lupus erythematosus].
The enzyme poly-(ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair. During programmed cell death (apoptosis), PARP is enzymatically cleaved. Detection of the cleavage products is characteristic for apoptosis. In patients with systemic lupus erythematosus (SLE), the highly ordered signal transduction cascade of apoptosis is disturbed. SLE patients show reduced PARP activity . PARP cleavage products are mainly found in association with either antinuclear and/or anti-dsDNA antibodies. In addition, serum samples from SLE patients and other autoimmune diseases display anti-PAR and anti-PARP autoantibodies.
Radiologische Universitätsklinik der Rheinischen Friedrich-Wilhelms Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn. i.boehm@uni-bonn.de
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D000974:Antibodies, Antinuclear / Q000097:blood; D017209:Apoptosis / Q000502:physiology*; D001323:Autoantibodies / Q000097:blood; D004247:DNA / Q000276:immunology; D006801:Humans; D007970:Leukopenia / Q000201:enzymology; D008180:Lupus Erythematosus, Systemic / Q000201:enzymology* / Q000276:immunology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000172:deficiency* / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004247:DNA; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases