Long-term evaluation of lipid profile and oral glucose tolerance test in Norplant users.
OBJECTIVE
This study reports the results of the lipid profile and oral glucose tolerance test (OGTT) in 46 normal patients tested before and after 5 years of Norplant use.


RESULTS
After 5 years, there was a substantial decrease of 28.9% in high-density lipoprotein cholesterol levels and a similar but less pronounced fall of 7.1% in the total cholesterol levels. The Castelli 1 index did not vary, and the triglycerides and low-density lipoprotein cholesterol levels remained normal and unchanged throughout the study period. All the mean values of OGTT were significantly lower after 5 years, except for the 90-min glycemia.


CONCLUSIONS
These findings indicate that long-term Norplant use does not increase cardiovascular risks.
Araujo
Fabio F
FF
Department of Obstetrics and Gynecology, Universidade Federal de São Paulo-Escola Paulista de Medicina, Brazil. arujoff@aol.com
de Lima
Geraldo Rodrigues
GR
Guazzelli
Cristina A F
CA
Barbieri
Márcia
M
Vigorito
Neusa M
NM
Lindsey
Prescilla C
PC
Baracat
Edmund C
EC
D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D016912:Levonorgestrel / Q000009:adverse effects*; D008055:Lipids / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D016912:Levonorgestrel; D002784:Cholesterol