[Clinical analysis of gastrointestinal stromal tumor: a report of 29 patients].
OBJECTIVE
To investigate the clinical manifestations, diagnosis and treatment of gastrointestinal stromal tumor (GIST).


METHODS
Clinicopathological data of 29 cases with GIST from 2003 to 2005 were retrospectively analyzed.


RESULTS
The most common clinical manifestations were abdominal pain, distention or discomfort in 16 cases (55.2%), abdominal mass in 9 (31.0%), melena and hematemesis in 5 cases (17.2%). The tumor was located in the stomach in 16 cases, the small intestine in 9, the colorectum in 2, the esophagus in one, and the duodenum in one case. All the cases underwent operation, included total gastrectomy in one case, subtotal gastrectomy in 8, partial gastrectomy in 4, local excision of the tumor in 5 cases, partial small intestine resection in 9 and right colectomy in 2 cases. The resection rate was 100% and no complication and death occurred. The positive rates of CD117(+) and CD34(+) were 93.1% and 51.7% respectively. After follow up from one to 2 years after operation, 2 cases died of tumor recurrence and metastasis, the others survived.


CONCLUSIONS
Immunohistochemical examinations of CD117 and CD34 are important diagnostic markers. Surgery is the main method of final diagnosis and treatment.
Department of General Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China. hdqin77@126.com
Hua-dong
HD
Qin
Dong-wei
DW
Zhang
Wei-liang
WL
Yang
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D015415:Biomarkers; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012189:Retrospective Studies
D018952:Antigens, CD34; D015415:Biomarkers; D019009:Proto-Oncogene Proteins c-kit