Human chromosome 11 DNA sequence and analysis including novel gene identification.
Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here--nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence--provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. taylor@gsc.riken.jp
Todd D
TD
Taylor
Hideki
H
Noguchi
Yasushi
Y
Totoki
Atsushi
A
Toyoda
Yoko
Y
Kuroki
Ken
K
Dewar
Christine
C
Lloyd
Takehiko
T
Itoh
Tadayuki
T
Takeda
Dae-Won
DW
Kim
Xinwei
X
She
Karen F
KF
Barlow
Toby
T
Bloom
Elspeth
E
Bruford
Jean L
JL
Chang
Christina A
CA
Cuomo
Evan
E
Eichler
Michael G
MG
FitzGerald
David B
DB
Jaffe
Kurt
K
LaButti
Robert
R
Nicol
Hong-Seog
HS
Park
Christopher
C
Seaman
Carrie
C
Sougnez
Xiaoping
X
Yang
Andrew R
AR
Zimmer
Michael C
MC
Zody
Bruce W
BW
Birren
Chad
C
Nusbaum
Asao
A
Fujiyama
Masahira
M
Hattori
Jane
J
Rogers
Eric S
ES
Lander
Yoshiyuki
Y
Sakaki
D002880:Chromosomes, Human, Pair 11; D004247:DNA; D015870:Gene Expression; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D018035:Receptors, Odorant / Q000235:genetics; D017422:Sequence Analysis, DNA
D018035:Receptors, Odorant; D004247:DNA