[Prostate cancer chemoprevention].
Prostatic cancer is the most common malignancy diagnosed in men. Chemoprevention of prostatic cancer is a relatively new concept and seems to be a very promising strategy for preventing and arresting the development of this neoplasm. There is much evidence that the increased consumption of selenium, vitamins E and D, lycopen, soy and isoflavonoids and low-fat diet reduce the risk of the incidence of prostatic cancer. Similar effect is also exhibited by some drugs including finasteride, non-steroid anti-inflammatory drugs and lipoxygenase inhibitors. In this paper we summarize the results of published epidemiologic and scientific studies, trying to critically evaluate the potential clinical role and mechanism of action of these agents in modern chemoprevention of this cancer.
Krysiak
Robert
R
Katedra Farmakologii, Zakład Farmakologii Klinicznej, Slaskiej Akademii Medycznej, Katowice. r.krysiak@pharmanet.com.pl
Okopień
Bogusław
B
Szkróbka
Witold
W
Herman
Zbigniew Stanisław
ZS
D002338:Carotenoids / Q000627:therapeutic use; D004358:Drug Therapy / Q000379:methods*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D018120:Finasteride / Q000627:therapeutic use; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use; D000077276:Lycopene; D008297:Male; D011471:Prostatic Neoplasms / Q000178:diet therapy / Q000517:prevention & control*; D012643:Selenium / Q000627:therapeutic use; D045730:Soy Foods; D014801:Vitamin A / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D007529:Isoflavones; D014801:Vitamin A; D014807:Vitamin D; D014810:Vitamin E; D002338:Carotenoids; D018120:Finasteride; D012643:Selenium; D000077276:Lycopene