Picking out the details of cerebellar LTD.
Cerebellar long-term depression is thought to underlie motor learning and is mediated by internalization of AMPA receptors from the neuronal plasma membrane. In this issue of Neuron, Steinberg et al. provide firm evidence that PICK 1 and the C terminus of GluR2 are central to this process by analyzing three different transgenic mice.
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
Jonathan G
JG
Hanley
Jeremy M
JM
Henley
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D018797:Cell Cycle Proteins; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D018091:Receptors, AMPA / Q000502:physiology
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; C091822:Prkcabp protein, mouse; D018091:Receptors, AMPA; C104722:glutamate receptor ionotropic, AMPA 2