Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.
Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in inducible proton conductance. They dissipate the proton electrochemical gradient established by the respiratory chain at the expense of reducing substrates. Several physiological roles have been suggested for uncoupling proteins, including roles in the control of the cellular energy balance and in preventive action against oxidative stress. This review focuses on new leads emerging from comparative proteomics about the involvement of uncoupling protein in the mitochondrial physiology. A brief overview on uncoupling proteins and on proteomics applied to mitochondria is also presented herein.
Douette
Pierre
P
Laboratory of Bioenergetics, Bât. B6C, Allée de la chimie 3, 4000Liège, Belgium.
Sluse
Francis E
FE
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D005234:Fatty Liver / Q000503:physiopathology; D006801:Humans; D007473:Ion Channels; D008565:Membrane Proteins / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D008930:Mitochondria, Liver / Q000502:physiology; D024101:Mitochondrial Proteins; D010084:Oxidation-Reduction; D040901:Proteomics; D011685:Purine Nucleotides / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D014451:Ubiquinone / Q000737:chemistry; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011685:Purine Nucleotides; D011994:Recombinant Proteins; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; D014451:Ubiquinone