Seroprevalence study of feline coronavirus in owned and feral cats in Sydney, Australia.
OBJECTIVE
i) To establish the seroprevalence of Feline Coronavirus (FCoV) infection in two defined groups of cats in Sydney: owned and feral cats; ii) to identify factors associated with an increased risk of infection with FCoV; and iii) to establish the seroprevalence and FCoV antibody titres of owned cats with immunohistochemically confirmed feline infectious peritonitis (FIP).


METHODS
Prospective multi-institutional cross sectional study. Procedure Serum samples from owned cats presented to three inner city veterinary clinics in Sydney and feral cats from a colony in South Western Sydney over an 11-month period were tested for FCoV antibodies using the Immunocomb test kit. The relationship between serological score and six major factors (breed, age, gender, number of cats per household, living environment and health status) in the owned cat sample population was analysed and compared to cats with FIR RESULTS: The seroprevalence of FCoV infection in the sample population of owned and feral cats was 34% and 0%, respectively. The median Immunocomb scores of DSH, Persian, Siamese and Devon Rex cats were significantly lower than that of Burmese, BSH, Abyssinian, Birman, Ragdoll and Russian Blue. The median lmmunocomb score of pedigree cats less than 2 years-of-age was significantly higher than for pedigree cats greater than 2 years-of-age. This distinction was not evident in DSH cats in these age groups. The number of cats per household at the time of blood collection had a strong positive association with Immunocomb score. The median Immunocomb score of cats with immunohistochemically confirmed FIP was significantly higher than cats in the sample population of owned cats but there was sufficient overlap between these two groups to make definitive diagnosis of FIP by serology impossible.


CONCLUSIONS
This represents the first seroprevalence study of FCoV in Australia. The major determinants of antibody score of owned cats identified in this study were breed, age and the number of cats per household. The significant relationship between the breed of the cat and the FCoV antibody titre further supports the notion, proposed previously by the authors, that breed related differences exist in the immunological response to FCoV infection.
Faculty of Veterinary Science, Building B14, The University of Sydney, New South Wales 2006.
E T
ET
Bell
J A L M L
JA
Toribio
J D
JD
White
R
R
Malik
J M
JM
Norris
D000367:Age Factors; D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D000914:Antibodies, Viral / Q000097:blood; D002415:Cats; D016765:Coronavirus, Feline / Q000276:immunology*; D003430:Cross-Sectional Studies; D016766:Feline Infectious Peritonitis / Q000453:epidemiology*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D010375:Pedigree; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral