Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn.
Oesophageal visceral hypersensitivity is thought to be important in generating symptoms in functional heartburn (FH). However, the neurophysiological mechanisms involved are poorly understood. The aim of this study was to compare the characteristics of oesophageal cortical evoked potentials (CEPs) induced by balloon distension and acid perfusion in FH and controls. We studied 21 FH patients and 12 healthy volunteers. Oesophageal mechanical stimulation was performed using the specially constructed mechanical pump. CEPs were recorded using the 10-20 international system of electroencephalogram recording. Oesophageal distention elicited recognizable, reproducible and muti-peak CEPs. CEP latencies for N1, P1 and N2 components were significantly shorter (P = 0.016, P = 0.003 and P = 0.031, respectively) in FH than in controls before perfusion. Acid perfusion significantly decreased the latencies of N1, P1 and N2 (P = 0.022, P = 0.007 and P = 0.041, respectively) and significantly increased the amplitude of P1-N2 components (P = 0.020) in FH patients, but not in controls. In conclusion, cortical evoked potential responses evoked by oesophageal distention and acid perfusion were greater in FH than in controls, suggesting that dysfunction of visceral neural pathways and/or alterations in cortical processing may produce and mediate oesophageal hypersensitivity in FH. These findings provide the evidence that central sensitization contributes to the development and maintenance of oesophageal hypersensitivity.
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
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M
Yang
Z-S
ZS
Li
X-R
XR
Xu
D-C
DC
Fang
D-W
DW
Zou
G-M
GM
Xu
Z-X
ZX
Sun
Z-X
ZX
Tu
D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000502:physiology*; D004106:Dilatation; D004569:Electroencephalography; D004947:Esophagus / Q000294:innervation*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006356:Heartburn / Q000503:physiopathology*; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010477:Perfusion
D006851:Hydrochloric Acid