Stem cells and their potential relevance to paediatric cardiology.
Basic scientists, as well as cardiologists, are caught by the idea of curing ischaemic heart disease with cardiac progenitor or stem cells. This short review provides an overview of our current knowledge on the potential use of stem cells for cardiac disease. Since, in infants and children, aetiologies and pathomechanisms of critical cardiac disease are fundamentally different from those in adults, we will also address the question as to whether such young patients could be a therapeutic target at all, and in which respect it may be necessary to view treatment with stem cells from a different stance in the developing organism.
Paediatric Cardiology, University of Cologne, Cologne, Germany.
Frank
F
Pillekamp
Michael
M
Reppel
Konrad
K
Brockmeier
Jürgen
J
Hescheler
D000293:Adolescent; D001854:Bone Marrow Cells; D002309:Cardiology; D002318:Cardiovascular Diseases / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010372:Pediatrics; D033581:Stem Cell Transplantation / Q000941:ethics / Q000379:methods; D013234:Stem Cells / Q000145:classification / Q000502:physiology