[Recent trends in evaluating risk associated with acrylamide in foods. --Focus on a new approach (MOE) to risk assessment by JECFA--].
The safety of acrylamide in foods was evaluated in the 64th meeting (2005) of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Acrylamide is classified as "probably carcinogenic to humans (Group 2A)" by the International Agency for Research on Cancer (IARC) from evidence of carcinogenicity in experimental animals and from evidence that acrylamide is metabolized to a genotoxic compound, glycidamide, in both rodents and humans. Acrylamide is also known to have genotoxicity, neurotoxicity, reproductive and developmental toxicity. In this meeting, the Committee used "Margin of Exposure (MOE)" as a new approach to risk assessment for compounds that were both genotoxic and carcinogenic, the lower the MOE the greater the health concern. JECFA calculated MOE values of 300 for the general population and 75 for consumers of large quantities of food containing high acrylamide. These MOEs were considered low and a potential human health concern. Therefore, appropriate efforts to reduce acrylamide concentrations in foodstuffs should continue. This report discusses how JECFA applied the MOE concept to the risk assessment of acrylamide in foods.
miou@nihs.go.jp
Miou
M
Toda
Chikako
C
Uneyama
Miyako
M
Yamamoto
Kaoru
K
Morikawa
D020106:Acrylamide / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D003257:Consumer Product Safety; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis / Q000517:prevention & control*; D006801:Humans; D007390:International Agencies / Q000458:organization & administration; D018570:Risk Assessment / Q000379:methods / Q000639:trends
D002273:Carcinogens; D020106:Acrylamide