Changes of nitric oxide, oxide free radicals, and systolic arterial blood pressure in rats with experimental lymphatostatic encephalopathy.
The model of lymphatostatic encephalopathy was established by occluding and removing profound cervical nodes in rats, and the kinetic alteration of nitric oxide (NO), maleic dialdehyde (MDA), free radical scavenger (CuZn-SOD) and arterial systolic blood pressure were determined on different days after the blockage. The results showed that the level of NO significantly decreased at 1 day (P<0.05) and further decreased at 3, 5 and 7 day (P<0.01). The levels of MDA at 1, 3, 5 and 7 day significantly increased, but the contents of CuZn-SOD significantly decreased compared with the control (P<0.01). There was negative correlation between the levels of MDA and CuZn-SOD, but there was no relationship between MDA an NO. Arterial systolic blood pressure decreased progressively after cervical lymphatic blockage. The results showed that NO, oxide free radicals and the disturbances of the cardiovascular regulation may play important roles in lymphatostatic encephalopathy.
Xia
Zuo-Li
ZL
Institute of Microcirculation, Affiliated Hospital, Taishan Medical College, Taian, Shandong 271000, China. zlxia01@126.com
Sun
Bao-Liang
BL
Zheng
Yan-Hong
YH
Yang
Ming-Feng
MF
Song
Xi-Jun
XJ
Hao
Fang
F
Zhao
Xiao-Min
XM
Xu
Chang-Qing
CQ
D000447:Aldehydes; D000818:Animals; D001794:Blood Pressure; D001927:Brain Diseases / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D005609:Free Radicals / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase; D013599:Systole
D000447:Aldehydes; D005609:Free Radicals; C015977:malealdehyde; D009569:Nitric Oxide; D013482:Superoxide Dismutase