Airway smooth muscle as a regulator of immune responses and bronchomotor tone.
The traditional view of airway smooth muscle (ASM) in asthma, as a purely contractile tissue, seems to be inadequate. Compelling evidence now suggests that ASM plays an important role in regulating bronchomotor tone, in perpetuating airway inflammation, and in remodeling of the airways. This article reviews three distinct functions of ASM cells: the process of excitation-contraction coupling, with a particular focus on the role of cytokines in modulating calcium responses; the processes of smooth muscle cell proliferation and migration; and the synthetic and immunomodulatory function of ASM cells. This article also discusses how altered synthetic function contributes to airway remodeling.
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA. Aili.L.Lazaar@gsk.com
Aili L
AL
Lazaar
Reynold A
RA
Panettieri
D001249:Asthma / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008168:Lung / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D032389:Myocytes, Smooth Muscle / Q000502:physiology*
D016207:Cytokines; D002118:Calcium