HLA-DRB1 genes and extraarticular rheumatoid arthritis.
The factors that trigger the development of extraarticular features of rheumatoid arthritis (RA) are still unknown. HLA-DR alleles such as HLA-DR4 and HLA-DR1 are associated with the risk to develop RA. A large scale study from Sweden and the Mayo Clinic suggests that HLA-DR4, but not HLA-DR1, is associated with the risk to develop extraarticular RA.
Roudier
Jean
J
INSERM UMR 639, Université de la Méditerranée,13005, Marseille, France. jean.roudier@medecine.univ-mrs.fr
D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains