[Altered ability to learn of rat offspring with iodine deficiency].
Experimental data demonstrate that hypothyroidism could result in depressive behavior and subsequently thyroid hormones could act as antidepressants. Postnatal changes in learning ability, memory and emotional status in posterity of rats, which have experienced different level of iodine deficiency before conception and during all gestation period were investigated in this study. Results obtained suggest that sudden iodine deprivation before and during gestation led to a significant neurological defect, which was represented by loss of ability to learn, one of the most important functions of brain in newborn and by evidence of depression. Iodine supply to the diet of female rats eliminates these effects completely.
Tsintsadze
T G
TG
Gabrichidze
G O
GO
Lazrishvili
N I
NI
Metreveli
D S
DS
Mitagvariia
N P
NP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D003409:Congenital Hypothyroidism / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D007455:Iodine / Q000172:deficiency*; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D011193:Potassium Iodide / Q000008:administration & dosage / Q000627:therapeutic use; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism
D013963:Thyroid Hormones; D011193:Potassium Iodide; D007455:Iodine