Trophoblast differentiation: progenitor cells, fusion and migration -- a workshop report.
Challenge lies ahead in unravelling the role played by trophoblast and its repertoire of expressed genes in normal human placental development, growth and pathology. Specific technical advances will clearly be required for characterisation of function. In particular, improvements in our repertoire of in vitro models are needed before many of the key questions can be answered. Recent advances in the study of human trophoblast differentiation are discussed.
Division of Human Development, University of Manchester, St Mary's Hospital, Manchester M13 0JH, UK. john.aplin@manchester.ac.uk
J D
JD
Aplin
S L
SL
Straszewski-Chavez
B
B
Kalionis
C
C
Dunk
D
D
Morrish
K
K
Forbes
D
D
Baczyk
N
N
Rote
A
A
Malassine
M
M
Knöfler
D002450:Cell Communication; D002454:Cell Differentiation; D002459:Cell Fusion; D019070:Cell Lineage; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D013234:Stem Cells / Q000502:physiology*; D014327:Trophoblasts / Q000502:physiology*