Hodgkin lymphoma, multiple myeloma, soft tissue sarcomas, insect repellents, and phenoxyherbicides.
OBJECTIVE
The objective of this study was to determine if there is an additional risk of developing Hodgkin lymphoma, multiple myeloma, or soft tissue sarcoma as a consequence of exposure to a combination of phenoxyherbicides, rubber gloves, DEET (N, N-diethyl-m-toluamide), and sunlight compared with each of the individual chemicals.


METHODS
This was a population-based study of men with specific cancers and age, province-matched control subjects.


RESULTS
No additional risk from these combinations of exposures of developing these three types of tumor was found in contrast to non-Hodgkin lymphoma.


CONCLUSIONS
The mechanisms by which phenoxyherbicides contribute to the risk of multiple myeloma and non-Hodgkin lymphoma may be different.
Institute of Agricultural Rural and Environmental Health, University of Saskatchewan, Saskatchewan, Canada.
Punam
P
Pahwa
Helen H
HH
McDuffie
James A
JA
Dosman
John R
JR
McLaughlin
John J
JJ
Spinelli
Diane
D
Robson
Shirley
S
Fincham
D015084:2,4-Dichlorophenoxyacetic Acid / Q000009:adverse effects; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000453:epidemiology; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D003671:DEET / Q000009:adverse effects*; D003996:Dicamba / Q000009:adverse effects; D017575:Gloves, Protective / Q000009:adverse effects; D006540:Herbicides / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007302:Insect Repellents / Q000009:adverse effects*; D008297:Male; D008397:Masks / Q000009:adverse effects; D009101:Multiple Myeloma / Q000139:chemically induced* / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D011481:Protective Clothing; D012307:Risk Factors; D012408:Rubber / Q000009:adverse effects; D012509:Sarcoma / Q000139:chemically induced* / Q000453:epidemiology; D013472:Sunlight / Q000009:adverse effects
D006540:Herbicides; D007302:Insect Repellents; D003671:DEET; D015084:2,4-Dichlorophenoxyacetic Acid; C008340:mecoprop; D012408:Rubber; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D003996:Dicamba