[Clinical study of guchong zhixue decoction in treating dysfunctional uterine bleeding of anovulatory type].
OBJECTIVE
To observe the efficacy of Guchong Zhixue Decoction (GCZXD) in treating dysfunctional uterine bleeding of anovulatory type with Qi-deficiency and blood stasis syndrome, and to systematically explore its hemostasis mechanism.


METHODS
Sixty patients were randomly divided into the treated group (n = 30, treated by GCZXD taken orally) and the control group (n=30, treated by Yigong Zhixue Oral Liquid, taken orally). Hemostatic effect of treatment, improvements of clinical symptoms, thickness of endometrium, prothrombin time (PT) and activated partial prothrombin time (APTT), serum level of Ca2+, endocrine hormone, levels of PGE2 and PGF2alpha in menstrual blood serum, and contents of endometrial estrogen receptor (ER) and progestin receptor (PR) before and after treatment were observed. Results The total effective rate of GCZXD in hemostasis was 93.3% in the treated group, which was significantly better than that in the control group (70.0%, P < 0.05). Significant difference was shown in improving clinical symptoms, thickness of endometrium, PT and APTT, serum level of Ca2+, endocrine hormone, levels of PGE2 and PGF2alpha in menstrual blood serum, and contents of endometrial ER and PR in the treated group when compared with before treatment (P < 0.05, P < 0.01) also when compared with the control group after treatment (P < 0.05).


CONCLUSIONS
GCZXD has favorable hemostatic effect in treating dysfunctional uterine bleeding of Qi deficiency and blood stasis syndrome, and it also con improve the accompanied symptoms significantly.
Liu
Jin-xing
JX
The Affiliated Hospital of Shandong University of TCM, Jinan 250011. ljx276@sina.com
D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008516:Medicine, Chinese Traditional; D008796:Metrorrhagia / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal