Screening of selected indigenous plants of Cambodia for antiplasmodial activity.
The in vitro antiplasmodial activity of 117 aqueous, methanol and dichloromethane extracts derived from different parts of 28 indigenous wild plant species was studied. These plants are commonly used in Cambodian traditional medicine. The plant extracts were tested for in vitro activity against a chloroquine resistant Plasmodium falciparum strain (W2). Nine extracts were moderately active with IC(50) values ranging between 5 and 10 microg/ml, 17 extracts were active with IC(50) values ranging between 1 and 5 microg/ml. These 26 extracts derived from eight plants belong to six families. The most active extracts were dichloromethane and came from Stephania rotunda and Brucea javanica with IC(50) values of 1 microg/ml and a selectivity index > or = 25. It is interesting to note that some aqueous extracts were as active as dichloromethane extracts especially aqueous extracts of Stephania rotunda, Brucea javanica, Phyllanthus urinaria and Eurycoma longifolia with IC(50) values of < or = 4 microg/ml. These results are in agreement with statements of healers on traditional uses of these plants for the treatment of malaria and/or fever. In this study, we report the antiplasmodial potential activity of eight plant species from Cambodia. Among them four are tested for the first time.
Hout
Sotheara
S
Laboratoire de Parasitologie, Faculté de Pharmacie, Marseille, France.
Chea
Aun
A
Bun
Sok-Siya
SS
Elias
Riad
R
Gasquet
Monique
M
Timon-David
Pierre
P
Balansard
Guy
G
Azas
Nadine
N
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002160:Cambodia; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000145:classification*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D010936:Plant Extracts