Nickel-catalyzed asymmetric alpha-arylation of ketone enolates.
An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong.
Guoshu
G
Chen
Fuk Yee
FY
Kwong
Hoi On
HO
Chan
Wing-Yiu
WY
Yu
Albert S C
AS
Chan
D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism; D044024:Tetralones / Q000737:chemistry*
D007659:Ketones; D044024:Tetralones; D009532:Nickel