[Preparation of Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo].
OBJECTIVE
To study Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo.


METHODS
Establishing the best prescription of Xionggui nasal sprays through orthogonal design methods, The in vitro release action of Xionggui nasal sprays was studied using dynamic dialyse method. The in vivo rat nasal recirculation methods were used to study the rule of Xionggui nasal sprays absorption.


RESULTS
The optimum prescription was: Pemulen TR-1 0.35%, EDTA 0.2%, PEG400 1%, xanthan gum 0.2%; trolamine: right amount(adjust pH). Its release in vitro and absorption in vivo meet to Higuchi distribution.


CONCLUSIONS
The preparation method of Xionggui nasal sprays was appropriate. The release of drug and its uptake was well correlated.
Chen
Yan-jun
YJ
Institute of Cinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing. ivycyj@163.com
Jin
Ri-xian
RX
Yang
Hong-jun
HJ
Zhang
He
H
Zeng
Jing
J
D000042:Absorption; D000281:Administration, Intranasal; D000336:Aerosols; D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D004337:Drug Carriers; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004492:Edetic Acid; D004655:Emulsions; D004983:Ethanolamines; D005260:Female; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols; D011135:Polysaccharides, Bacterial; D051381:Rats; D017207:Rats, Sprague-Dawley
D000336:Aerosols; D004337:Drug Carriers; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D004983:Ethanolamines; D011135:Polysaccharides, Bacterial; D011092:Polyethylene Glycols; D004492:Edetic Acid; C009546:triethanolamine; C002563:xanthan gum