Epigenetic regulation of stem cell differentiation.
Stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages. Progression from stem cells into differentiated progeny requires long-lasting changes in gene expression. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNA-mediated regulatory events, are essential to controlling the heritable cellular memory of gene expression during development. Recent studies on cell fate specification of embryonic and adult stem cells/progenitors have highlighted a general and critical role for dynamic epigenetic regulation in stem cell self-renewal and differentiation.
Wu
Hao
H
Department of Molecular and Medical Pharmacology, Neuropsychiatric Institute, University of California, Los Angeles, School of Medicine, 90095, USA.
Sun
Yi Eve
YE
D000328:Adult; D002454:Cell Differentiation / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D012313:RNA / Q000235:genetics; D013234:Stem Cells / Q000166:cytology*
D012313:RNA