Regional transient osteoporosis of the foot and vitamin C deficiency.
We describe the clinical presentation and diagnostic tests of a patient with regional transient osteoporosis (RTO) of the foot. This patient presented with a 4-month history of left-foot pain, nonpitting edema, and brownish discolorations of both feet. He had a history of tobacco abuse, alcohol abuse, and malnutrition. Radiological studies revealed severe osteopenia in the feet, and a MRI revealed bone marrow edema. The bone biopsy was consistent with RTO. This patient also had vitamin C deficiency. This case suggests a link between vitamin C deficiency and RTO, a hypothesis supported by our review of relevant literature on osteoporosis and vitamin C.
Rodriguez
Sandra
S
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street STOP 9410, Lubbock, TX 79430, USA.
Paniagua
Oscar
O
Nugent
Kenneth M
KM
Phy
Michael P
MP
D001205:Ascorbic Acid / Q000627:therapeutic use*; D001206:Ascorbic Acid Deficiency / Q000150:complications* / Q000503:physiopathology; D001851:Bone Diseases, Metabolic; D019587:Dietary Supplements; D005529:Foot Bones / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography
D001205:Ascorbic Acid