Change of refractive state and eye size in children of birth weight less than 1701 g.
OBJECTIVE
To determine the refractive status and ocular dimensions of a cohort of children at age 10-12 years with birth weight below 1701 g, and also the relation between the neonatal ophthalmic findings and subsequent refractive state.


METHODS
293 low birthweight children who had been examined in the neonatal period were assessed at 10-12 years of age. The examination consisted of autorefraction, keratometry, and A-scan. Results of right eyes were compared with published normative data.


RESULTS
293 of the birth cohort of 572 children consented to participate. The average mean spherical equivalent (MSE) in the low birthweight cohort was +0.691 dioptre, significantly higher than the control data (+0.30D, p = 0.02). The average change in MSE over the 10-12 year period was -1.00 dioptre (n = 256), but only 62.1% of cases showed a shift in refractive error of the appropriate magnitude and direction. The presence of any retinopathy of prematurity (ROP) increases the risk of developing anisometropia sixfold.


CONCLUSIONS
Low birth weight and ROP both significantly impact the refractive state in the long term. At age 10-12 years children born preterm have an increased prevalence of all refractive errors. In low birthweight children refractive state is relatively stable over the first decade of life with a shift towards myopia of 1 dioptre.
O'Connor
A R
AR
Division of Orthoptics, Thompson Yates Building, Quadrangle, University of Liverpool, Liverpool L69 3GB, UK. annaoc@liverpool.ac.uk
Stephenson
T J
TJ
Johnson
A
A
Tobin
M J
MJ
Ratib
S
S
Fielder
A R
AR
D001724:Birth Weight; D002648:Child; D005123:Eye / Q000254:growth & development* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012178:Retinopathy of Prematurity / Q000150:complications; D012720:Severity of Illness Index