Adrenomedullin: a new and promising target for drug discovery.
Adrenomedullin (AM) is a 52 amino acid peptide that plays a critical role in several diseases such as hypertension, cancer, diabetes, cardiovascular and renal disorders, among others. Interestingly, AM behaves as a protective agent against some pathologies, yet is a stimulating factor for other disorders. Thus, AM can be considered as a new and promising target for the design of non-peptidic modulators that could be useful for the treatment of those pathologies, by regulating AM levels or the activity of AM. A full decade on from its discovery, much more is known about AM molecular biology and pharmacology, but this knowledge still needs to be applied to the development of clinically useful drugs.
García
Mario A
MA
Universidad San Pablo CEU, Departamento de Química, Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain.
Martín-Santamaría
Sonsoles
S
de Pascual-Teresa
Beatriz
B
Ramos
Ana
A
Julián
Miguel
M
Martínez
Alfredo
A
D053607:Adrenomedullin; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010455:Peptides / Q000378:metabolism* / Q000502:physiology
D010455:Peptides; D053607:Adrenomedullin