Additive risk models for survival data with high-dimensional covariates.
As a useful alternative to Cox's proportional hazard model, the additive risk model assumes that the hazard function is the sum of the baseline hazard function and the regression function of covariates. This article is concerned with estimation and prediction for the additive risk models with right censored survival data, especially when the dimension of the covariates is comparable to or larger than the sample size. Principal component regression is proposed to give unique and numerically stable estimators. Asymptotic properties of the proposed estimators, component selection based on the weighted bootstrap, and model evaluation techniques are discussed. This approach is illustrated with analysis of the primary biliary cirrhosis clinical data and the diffuse large B-cell lymphoma genomic data. It is shown that this methodology is numerically stable and effective in dimension reduction, while still being able to provide satisfactory prediction and classification results.
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Shuangge
S
Ma
Michael R
MR
Kosorok
Jason P
JP
Fine
D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000401:mortality; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000401:mortality; D016016:Proportional Hazards Models; D012306:Risk; D018401:Sample Size; D015996:Survival Rate