Hemoglobin contrast in magnetomotive optical Doppler tomography.
We introduce a novel contrast mechanism for imaging blood flow by use of magnetomotive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect erythrocytes moving according to the field gradient. Hemoglobin contrast was demonstrated in a capillary tube filled with moving blood by imaging the Doppler frequency shift, which was observed independently of blood flow rate and direction. Results suggest that MM-ODT may be a promising technique with which to image blood flow.
Kim
Jeehyun
J
Beckman Laser Institute and Medical Clinic, University of California at Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA. jeehk@uci.edu
Oh
Junghwan
J
Milner
Thomas E
TE
Nelson
J Stuart
JS
D001783:Blood Flow Velocity / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008280:Magnetics / Q000295:instrumentation*; D008297:Male; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D018608:Ultrasonography, Doppler / Q000295:instrumentation* / Q000379:methods