[Investigation on the properties of mitoxantrone-insulin conjugates lyophilized powder].
In this study we prepared mitoxantrone-insulin conjugate wherein mitoxantrone was an anticancer model drug and insulin acted as its vector leading to tumor cells. The drug loading of the conjugate was determined to be 11.68%. Stability trials of the conjugate were carried out in different pH buffer solutions and mouse plasma under 37 degrees C which showed the stability of the conjugate in vitro. Lyophilized powder was prepared and its pharmaceutical qualities were assessed. The retained biological activity of the insulin within the conjugate, demonstrated by animal experiments.
School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100054, China.
Wensheng
W
Liu
Zhirong
Z
Zhang
Yuan
Y
Huang
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D007328:Insulin / Q000737:chemistry*; D051379:Mice; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D011208:Powders
D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D007328:Insulin; D011208:Powders; D008942:Mitoxantrone