Frozen section diagnosis of pancreatic malignancy: a sensitive diagnostic technique.
BACKGROUND
Patients with potentially resectable pancreatic masses, without evidence of metastatic disease, require surgical exploration. We assessed the reliability of frozen section diagnosis of pancreatic malignancy.


METHODS
We analysed data from 120 patients who underwent pancreatic exploration, including frozen section assessment, over a period of 41 months.


RESULTS
A total of 310 pancreatic biopsies were sent for frozen section analysis. The frozen section result concurred with the final histological diagnosis in 98.1% of biopsies. The false-negative rate was 1.9%, with the correct diagnosis being established on subsequent frozen section in half of these cases. Only 3 patients were not correctly diagnosed intra-operatively by frozen section. The majority of tumours identified were pancreatic ductal adenocarcinomas, but endocrine tumours and lymphoma were also detected. 15 (12.5%) patients required more than one set of biopsies in order to establish a diagnosis of malignancy. 19 (15.8%) patients had malignant disease outside the pancreas, making their tumours unsuitable for curative resection.


CONCLUSIONS
Frozen section diagnosis is very reliable in the assessment of pancreatic masses and accurately differentiates between benign and malignant disease. More than one biopsy is needed to make a diagnosis, and if clinically suspicious, successive sets of biopsies may be required.
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK. hd24@leicester.ac.uk
H
H
Doucas
C P
CP
Neal
K
K
O'Reilly
A R
AR
Dennison
D P
DP
Berry
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology