Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats.
Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.
Department of Biochemistry, University of Madras, Guindy Campus Chennai 600 025, India.
S
S
Prabhu
Mallika
M
Jainu
K E
KE
Sabitha
C S Shyamala
CS
Devi
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D044004:Xanthones / Q000494:pharmacology*
D002316:Cardiotonic Agents; D044004:Xanthones; C013592:mangiferin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007545:Isoproterenol