Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients.
We evaluated interobserver reproducibility for the response evaluation criteria in solid tumors (RECIST) guidelines and the influence of minimum lesion size (MLS) on reproducibility. The 110 consecutive patients with non-small cell lung cancer were treated with platinum-based chemotherapy. Five observers measured target lesions according to both the World Health Organization (WHO) criteria and RECIST. The percentage changes for unidimensional measurements (UD; RECIST type) and bidimensional measurements (BD; WHO type) were calculated for each patient. Interobserver reproducibility among five observers, that is 10 pairs, was expressed as the Spearman's correlation coefficient for the percentage changes, the proportion of agreement and the kappa statistics for response categories. The same analysis was carried out using MLS. BD was more reproducible than UD (Spearman rank correlation coefficient, 0.84 vs 0.81; proportion of agreement, 84.4% vs 82.5%; kappa value, 0.69 vs 0.61). When MLS was applied to UD, eligible cases decreased by 6.4% and the number of target lesions by 44.6%, whereas interobserver reproducibility for UD improved (Spearman rank correlation coefficient, 0.81-0.84; proportion of agreement, 82.5-84.2%; kappa value, 0.61-0.65). The introduction of MLS to UD could also improve intercriteria reproducibility between WHO and RECIST. It is important to apply the MLS when using RECIST for the comparable interobserver reproducibility attained with WHO.
Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. h-watanabe@kcc.zaq.ne.jp
Hirokazu
H
Watanabe
Hideo
H
Kunitoh
Seiichiro
S
Yamamoto
Shin
S
Kawasaki
Akira
A
Inoue
Katsuyuki
K
Hotta
Kazu
K
Shiomi
Masahiko
M
Kusumoto
Kazuro
K
Sugimura
Nagahiro
N
Saijo
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D002986:Clinical Trials as Topic / Q000592:standards; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D017671:Platinum Compounds / Q000627:therapeutic use; D017410:Practice Guidelines as Topic / Q000592:standards*; D014057:Tomography, X-Ray Computed; D014944:World Health Organization
D000970:Antineoplastic Agents; D017671:Platinum Compounds