Asymmetric synthesis of trans-2,5-disubstituted pyrrolidines from enantiopure homoallylic amines. Synthesis of pyrrolidine (-)-197B.
Iodocyclization of sulfinimine-derived enantiopure homoallylic sulfonamides affords trans-2,5-disubstituted 3-iodopyrrolidines and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring system.
Department of Chemistry, Temple University, Philadelphia, PA 19122, USA. fdavis@temple.edu
Franklin A
FA
Davis
Minsoo
M
Song
Alexander
A
Augustine
D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
D011759:Pyrrolidines; D013449:Sulfonamides; C516087:pyrrolidine 197B