[Alloimmunization to a high frequency Rh antigen].
We report the case of a pregnant woman sensitized with a panreactive anti-Rh17 alloantibody. Patient's red blood cells showed a partial deletion of Rh antigens, which was responsible for the alloimmunization. An autotransfusion program was instrumented so as to cover possible demands. Molecular analysis of the RH locus showed the presence of a hybrid RHCE-D(5-7)-CE allele that gave origin to the deleted phenotype.
Laboratorio de Inmunohematología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina. ccotorru@fbioyf.unr.edu.ar
Carlos
C
Cotorruelo
Claudia
C
Biondi
Silvia Garcia
SG
Borras
Liliana
L
Racca
Daniel
D
Brunetti
Rene
R
Di Monaco
Amelia
A
Racca
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000276:immunology; D005838:Genotype; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D010641:Phenotype; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000276:immunology*; D012203:Rh Isoimmunization / Q000097:blood / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*
D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System