Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion.
The antiarrhythmogenic effect of the flavonoid dioclein on myocardial ischemia/reperfusion was investigated in isolated perfused rat hearts. Low concentrations of dioclein (30-300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein also preserved the diastolic tension after reperfusion without affecting the systolic tension. In addition, dioclein (150 nM) dramatically reduced the formation of reactive oxygen species (ROS) observed during reperfusion in hearts. In conclusion, dioclein acts as a potent antiarrhythmogenic and antioxidant drug with an excellent protective effect during reperfusion of ischemic hearts.
Vianna
Heloisa R
HR
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cortes
Steyner F
SF
Ferreira
Anderson J
AJ
Capettini
Luciano S A
LS
Schmitt
Martine
M
Almeida
Alvair P
AP
Massensini
André R
AR
Lemos
Virgínia S
VS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D007887:Fabaceae; D044950:Flavanones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000737:chemistry
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C094747:dioclein