A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.
There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been following an initial cohort of 5,092 seniors since 1995, has reported among its major findings the role of the Apolipoprotein E gene on modifying the risk for Alzheimer's disease (AD) in males and females and identifying pharmacologic compounds that may act to reduce AD risk. This article summarizes the major findings of the Cache County study to date, describes ongoing investigations, and reports preliminary analyses on the outcome of the oldest-old in this population, the subgroup of participants who were over age 84 at the study's inception.
Tschanz
Joann T
JT
Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan 84322-4440, USA. joannt@cc.usu.edu
Treiber
Katherine
K
Norton
Maria C
MC
Welsh-Bohmer
Kathleen A
KA
Toone
Leslie
L
Zandi
Peter P
PP
Szekely
Christine A
CA
Lyketsos
Constantine
C
Breitner
John C S
JC
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D006304:Health Status; D006801:Humans; D008136:Longevity; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D018570:Risk Assessment; D012307:Risk Factors; D012424:Rural Population; D012737:Sex Factors; D014589:Utah / Q000453:epidemiology
D053327:Apolipoprotein E4; D001057:Apolipoproteins E