Interferon production in mixed lymphocyte cell cultures.
Mixed lymphocyte cultures from mice with marked differences in major and minor histocompatibility antigens were found to produce an inhibitor of viral replication with properties of interferon. Cultures produced maximal amounts of interferon at approximately 72 to 96 hr, a time when maximal stimulation of deoxyribonucleic acid synthesis also occurred.
Gifford
G E
GE
Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida 32601.
Tibor
A
A
Peavy
D L
DL