[Regenerating activity and antibacterial effect of low-molecular-weight chitosan].
The antibacterial activity of two low-molecular-weight chitosans (LMWCs) was studied using two wound cultures: E. coli and St. albus. Both LMWCs exhibited antibacterial affect. The would-healing effect of methylcellulose gels comprising LMWCs (72 or 11 kDa) was studied. It was shown that wound-healing properties of gels depend on the molecular weight and concentration of LMWCs. The healing activity of LMWCs was assessed judging by the would half-closure time. The gels exhibiting the greatest healing rate contained 2% 72-kDa LMWC or 0.1% 11-kDa LMWC. The composition of the oligomeric fraction of the 11-kDa LMWC was studied by HPLC. It was shown that the oligomeric moiety of the 11-kDa LMWC represents a mixture of oligomers with a large admixture of monomers (30.82%).
Baĭtukalov
T A
TA
Bogoslovskaia
O A
OA
Ol'khovsakaia
I P
IP
Glushchenko
N N
NN
Ovsiannnikova
M N
MN
Lopatin
S A
SA
Varlamov
V P
VP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D005782:Gels; D008747:Methylcellulose / Q000737:chemistry; D051379:Mice; D008970:Molecular Weight; D013302:Streptomyces / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005782:Gels; D008747:Methylcellulose; D048271:Chitosan