[Study on the water-soluble composition release of compound Danshen sustained-release tablet].
OBJECTIVE
To study on the release of compound Danshen sustained-release tablet and the evaluate method of Chinese material medica compound sustained-release preparation.


METHODS
Rotating basket method and HPLC were employed.


RESULTS
Through the determination of 6 time-point samples, the water-soluble compositions of compound Danshen sustained-release tablet had a Well-balanced release behavior with a zero-grade release model or Higuchi release model.


CONCLUSIONS
Compound Danshen sustained-release tablet had a zero-grade release model. The method was rapid and stable and could be applied to evaluate the water-soluble composition release of compound Danshen sustained-release Tablet.
Zhu
Shen-shang
SS
Guangdong College of Pharmacy, Guangzhou, China.
Yuan
Xu-jiang
XJ
Li
Yuan-xin
YX
D001572:Benzofurans / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D036145:Ginsenosides / Q000032:analysis*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D053630:Depsides
D001572:Benzofurans; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D013607:Tablets; C076944:salvianolic acid B; D053630:Depsides; C035054:ginsenoside Rg1