Role of IkappaB kinase in tumorigenesis.
IkappaB kinase plays a central role in regulating NF-kappaB, is a key signaling molecule involved in controlling cell proliferation, survival, antiapoptosis, and tumorigenesis. Alternative pathways can also regulate NF-kappaB in an IkappaB kinase-independent manner. Emerging evidence indicates that IKK phosphorylates and inactivates forkhead box, class O (FOXO)-3a and promotes cell growth and tumorigenesis. Moreover, IKK and NF-kappaB play an important role in linking inflammation and tumorigenesis, and facilitate tumor maintenance and invasion. Thus, IKK and NF-kappaB are promising targets for drug discovery, and agents targeting the IKK/NF-kappaB and FOXO pathways may become therapeutic intervention for those patients with IKK/NF-kappaB-overexpressing cancers in the future.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. michu@mdanderson.org
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D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000502:physiology*; D007249:Inflammation / Q000150:complications; D019012:Integrin beta1 / Q000502:physiology; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology*; D015398:Signal Transduction
C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D019012:Integrin beta1; D051550:I-kappa B Kinase