Increased interferon production in human cells irradiated with ultraviolet light.
Polyinosinate-polycytidylate [poly(I).poly(C)]-induced interferon production in cultures of human foreskin fibroblast strains was increased by ultraviolet irradiation of cells at the time of exposure to inducer or at 2 h after induction. Incubation of cells with interferon prior to induction (priming) and ultraviolet irradiation exerted a cooperative enhancing effect on interferon production. The resulting interferon yields were generally somewhat higher than the yields from cultures subjected to sequential treatment with cycloheximide and actinomycin D.
Department of Microbiology, New York University School of Medicine, New York, New York 10016.
L W
LW
Mozes
E A
EA
Havell
M L
ML
Gradoville
J
J
Vilcek