Immune responses and HIV: a little order from the chaos.
HIV is evolution gone mad and bad. The virus infects a person and rapidly diversifies to become a huge swarm of viruses, each equipped differently to resist the onslaught of diverse T cells and antibodies. We can't expect to predict details of the struggle between virus and immunity, right? Wrong--maybe we can make some predictions, say two new landmark studies with potentially huge consequences for AIDS vaccine design.
O'Connor
David H
DH
University of Wisconsin-Madison, Department of Pathology and Laboratory Medicine, Madison, WI 53711, USA. doconnor@primate.wisc.edu
Burton
Dennis R
DR
D019943:Amino Acid Substitution; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D018791:CD4 Lymphocyte Count / Q000379:methods; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000235:genetics* / Q000276:immunology; D019143:Evolution, Molecular; D005260:Female; D005500:Follow-Up Studies; D015686:Gene Products, env / Q000235:genetics* / Q000276:immunology; D006679:HIV Seropositivity / Q000097:blood / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D008297:Male; D017354:Point Mutation
D000914:Antibodies, Viral; D018984:Epitopes, T-Lymphocyte; D015686:Gene Products, env