Systemic arteriopathy in SIV-infected rhesus macaques (Macaca mulatta).
BACKGROUND
Severe disseminated vasculopathy was observed in two simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta). These animals developed clinical signs of AIDS, including lymphadenopathy, weight loss, diarrhea and collapse.


CONCLUSIONS
Grossly, both animals showed emaciation, lymphadenopathy, vegetations on the mitral valve, renal infarcts and a dilated intestine; one animal had multifocal hemorrhages in multiple organs. Histologically, both cases had disseminated arteriopathy characterized by intimal thickening and fibrosis with varying degrees of vasculitis. The lesion was prominent in the kidney, intestine, pancreas, liver, heart, lymph nodes, spleen and testis. Occasional venules had intimal thickening. Both cases had cytomegalovirus (CMV) infection with intranuclear inclusions, CMV antigen and nucleic acid; some inclusions were observed in endothelial cells within some of the vascular lesions in one of the two. These data suggest that CMV caused the unusual lesions.
Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA, USA. yanai@cc.gifu-u.ac.jp
Tokuma
T
Yanai
Andrew A
AA
Lackner
Hiroki
H
Sakai
Toshiaki
T
Masegi
Meredith A
MA
Simon
D000818:Animals; D017809:Fatal Outcome; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000254:growth & development*; D014652:Vascular Diseases / Q000473:pathology / Q000821:virology*