Vaginal Lactobacillus isolates inhibit uropathogenic Escherichia coli.
The purpose of this study was to investigate the antibacterial activities of Lactobacillus jensenii KS119.1 and KS121.1, and Lactobacillus gasserii KS120.1 and KS124.3 strains isolated from the vaginal microflora of healthy women, against uropathogenic, diffusely adhering Afa/Dr Escherichia coli (Afa/Dr DAEC) strains IH11128 and 7372 involved in recurrent cystitis. We observed that some of the Lactobacillus isolates inhibited the growth and decreased the viability of E. coli IH11128 and 7372. In addition, we observed that adhering Lactobacillus strains inhibited adhesion of E. coli IH11128 onto HeLa cells, and inhibited internalization of E. coli IH11128 within HeLa cells.
Institut National de la Santé et de la Recherche Médicale, Faculté de Pharmacie, Université Paris XI, Châtenay-Malabry, France.
Fabrice
F
Atassi
Dominique
D
Brassart
Philipp
P
Grob
Federico
F
Graf
Alain L
AL
Servin
D018830:Adhesins, Escherichia coli / Q000378:metabolism; D000898:Antibiosis; D001422:Bacterial Adhesion; D003556:Cystitis / Q000382:microbiology; D004926:Escherichia coli / Q000254:growth & development* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D007778:Lactobacillus / Q000254:growth & development* / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*
D018830:Adhesins, Escherichia coli; C465564:Dr adhesin, E coli