EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome.
We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine. Soon after the introduction of carbamazepine, EEGs began to worsen, and finally absence seizures and myoclonic seizures appeared. Immediately after we discontinued carbamazepine, the seizures disappeared and the EEG improved. Carbamazepine may induce unusual electroclinical features, electrophysiologically explained by bilateral synchrony. This case provides more evidence of the close links between Panayiotopoulos syndrome and benign childhood epilepsy with centrotemporal spikes.
Department of Child Neurology, Okayama University, Japan. kkikumoto@mac.com
Kenichi
K
Kikumoto
Harumi
H
Yoshinaga
Makio
M
Oka
Minako
M
Ito
Fumika
F
Endoh
Tomoyuki
T
Akiyama
Yoko
Y
Ohtsuka
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013577:Syndrome; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid