Skin changes in pediatric transplant patients.
The advent of organ transplantation identified a new group of diseases. Dermatologists are studying transplant-associated diseases along with the atypical behavior of already known dermatoses. Pediatric patients have been treated as an extension of adult population, but unique aspects of age required clarification. A prospective cohort was studied including patients from both genders up to 17 yr of age who were recipients of kidney, liver or BMT during 2003 in Porto Alegre, Brazil. Regular skin examinations were performed up to the sixth month after the procedure, and an analysis was determined by ID (i.e. = number of skin changes/number of patients-month x 100). Thirty-nine patients were examined: 20 were kidney transplant recipients; 11 were BMT recipients (10 autologous transplants and 1 allogeneic transplant); and 8 were liver transplant recipients. Skin changes result primarily from the use of medication (87.2). Individually, kidney transplant patients presented the highest ID of skin changes because of medications (104.1). BMT recipients presented the highest ID of alterations occurring on skin appendages (85.4) and liver transplant recipients had the highest ID of vascular changes (94.9). In conclusion, this study shows that cutaneous alterations in pediatric transplant recipients present some particularities not described in adult recipients, such as ichthyosiform xerosis in renal recipients and skin scaling with pellagroid appearance in bone marrow recipients. Also, dermatoses secondary to medication use were the main finding in pediatric population.
Department of Dermatology of Hospital de Clínicas de Porto Alegre, RS, Brazil. apdsmanzoni@terra.com.br
Ana Paula Dornelles da Silva
AP
Manzoni
Ricardo Lapa
RL
Kruse
Carina
C
Troian
Vanessa Santos
VS
Cunha
Tania Ferreira
TF
Cestari
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D016031:Liver Transplantation; D052016:Mucositis / Q000209:etiology; D011184:Postoperative Period; D011446:Prospective Studies; D012871:Skin Diseases / Q000139:chemically induced / Q000209:etiology*; D014945:Wound Healing
D007166:Immunosuppressive Agents