[Combination therapy with acetylsalicylic acid and non-aspirin nonsteroidal anti-inflammatory drugs].
Patients may require both low-dose aspirin (ASA) and a nonsteroidal anti-inflammatory drug (NSAID). This raises the questions of whether NSAIDs may inhibit the cardioprotective effects of low-dose ASA; whether the cardioprotective effect of low-dose ASA can be obtained by NSAIDs: and whether the combination of low-dose ASA and NSAIDs increases the risk of adverse effects. This review attempts to answer these questions.
H:S Bispebjerg Hospital, Klinisk Farmakologisk Enhed, København NV. lr15@bbh.hosp.dk
Lene Ørskov
LØ
Reuther
Stig Ejdrup
SE
Andersen
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000037:antagonists & inhibitors; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002316:Cardiotonic Agents; D001241:Aspirin; D007052:Ibuprofen