[The role of oxygen-nitrogen stress in pathogenesis of amoebiasis].
The goal of present investigation was determining peculiarities of oxidation metabolism in the case amoebiasis. The activity of pro- and anti-oxidative systems and content of NO in the blood of the patients with abscess, which developed in hepatic amoebiasis, has been studied. It was shown that in the patients' organism an increased generation of the free radicals of oxygen and nitrogen does occur. Intensification of peroxidation of the lipids (POL) and inactivation of antioxidation system of the organism were observed as well. Intensifying of the oxygen-nitrogen stress in the organism of the patients with amoebiasis, is induced by the activated neutrophyls accumulated in the focus of injury, which developed during invasion of amoebas. Low efficiency of the neutrophyl-induced oxidation explosion in amoebiasis, partly is determined by the highly active anti-oxidative system of these parasites. Their sensitivity to NO, allows suggesting of implementation of preparations--NO donors and modulators of NO production in the host organism, in treatment of the parasitic infections.
Chikobava
G I
GI
Sanikidze
T V
TV
D004404:Dysentery, Amebic / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use; D009584:Nitrogen / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism*
D009569:Nitric Oxide; D009584:Nitrogen; D010100:Oxygen