[Study of the relative recovery of sinomenine microdialysis system and it's influential factor].
OBJECTIVE
(1) To study the effect of concentration and flow rate on relative recovery (RR); (2) To study the difference Of relative recovery between probes; (3) To study the relationship between relative recovery and relative loss (RL).


METHODS
HPLC.


RESULTS
(1) The sinomenine concentration has no obvious effect on RR in the same flow rate. (2) RR is reduced by exponent law as the flow rate increases. (3) There is significent difference between probes.


CONCLUSIONS
The RR isn't affected by sinomenine concentration as the flow rate is same. The flow rate has notable effect on RR as the sinomenine concentration is same. The RR of every probe should be assayed. We can take RL as RR to do in-vivo study.
Zhang
Yingfeng
Y
Guangzhou University of Traditional Chinese Medicine, Guangzhou.
Zhou
Liling
L
Wang
Xiaogen
X
Wang
Lisheng
L
D002851:Chromatography, High Pressure Liquid; D015314:Dialysis Solutions / Q000032:analysis; D066298:In Vitro Techniques; D017551:Microdialysis / Q000379:methods; D009019:Morphinans / Q000032:analysis* / Q000737:chemistry; D010599:Pharmacokinetics; D012015:Reference Standards
D015314:Dialysis Solutions; D009019:Morphinans; C009271:sinomenine