Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases alpha and beta and human terminal deoxynucleotidyl transferase (TdT).
The School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Jeremy R
JR
Doncaster
Laura L
LL
Etchells
Neil M
NM
Kershaw
Ryoichi
R
Nakamura
Hazel
H
Ryan
Ryo
R
Takeuchi
Kengo
K
Sakaguchi
Ali
A
Sardarian
Roger C
RC
Whitehead
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship
D001688:Biological Products; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D004253:DNA Nucleotidylexotransferase; D004259:DNA-Directed DNA Polymerase