Synthesis of non-nucleosides: 7- and 1,3-substituents of new pyrrolo[2,3-d]pyrimidin-4-ones on antiviral activity.
A series of non-nucleosides 9-47 were synthesized. Compounds 1-4 were reacted with formic acid (85%) to afford compounds 5-8. Then, the latter compounds were reacted with alkyl halides a-f (2-bromopropane, 2-bromobutane, benzyl bromide, benzyl chloromethyl ether, chloromethyl ethyl ether, phenacyl bromide) in the presence of NaH in dry DMF to give the desired compounds 9-47, which were evaluated for activity against herpes simplex virus type-II (HSV-II).
Department of Chemistry, Faculty of Science, Minoufiya University, Shebin El-Kom, Egypt. khaledhilmy@hotmail.com
Khalid Mohammed Hassan
KM
Hilmy
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D011744:Pyrimidinones; D011758:Pyrroles