Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression.
We have previously reported that the Ser9Gly dopamine D3 receptor (DRD3) polymorphism was associated with increased rates of obsessive-compulsive personality disorder (OCPD) symptomology. We tested the replicability of this association within a further two independent groups of individuals with a history of depression, from a clinical sample (n = 149) and a family study (n = 213). The data from the replication samples and the original sample, within which the association was found, were compiled within a meta-analysis. Although the independent samples did not replicate the original finding, the meta-analysis elucidated significant evidence supporting the association. An individual with Gly/Gly genotype is 2.4 (P = 0.017) times more likely to be diagnosed with OCPD. Male gender was also found to be a significant predictor of OCPD diagnosis (OR = 2.82, P = 0.001). An exploration of an association of DRD3 with Axis I anxiety disorder diagnoses and Temperament and Character Inventory (TCI) traits, in particular persistence, revealed no support for an association. We conclude that DRD3 may contribute to the development of OCPD.
Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, Christchurch, New Zealand. katrina.light@chmeds.ac.nz
Katrina J
KJ
Light
Peter R
PR
Joyce
Suzanne E
SE
Luty
Roger T
RT
Mulder
Christropher M A
CM
Frampton
Laura R M
LR
Joyce
Allison L
AL
Miller
Martin A
MA
Kennedy
D000328:Adult; D003193:Compulsive Personality Disorder / Q000150:complications / Q000235:genetics*; D003865:Major Depressive Disorder / Q000150:complications* / Q000523:psychology; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D050637:Receptors, Dopamine D3 / Q000235:genetics*
D050637:Receptors, Dopamine D3