[Effect of taurochenodeoxycholic acid on immune function in mice].
OBJECTIVE
To observe the influence of Taurochenodeoxycholic Acid (TCDCA) on immun, function in mice.


METHODS
T-Cell subgroups were determined by using Flow cytometry; The content of anti-body in serum was assayed by using Spectrophotometry; The phagocytosis of mononuclear phagocyte system was determined by using Carbon particle clearance test and anti-sheep blood cell hemolysin was determined by using Turbidimetric method.


RESULTS
TCDCA signifeantly enhanced the percentage of CD and CD19+ lymphocytes and CD4+/CD8+ value in peripheral blood and the content of serum hemolysin and lysozymem in mice. Moreover, TCDCA markedly improved the phagocytosis functions of mononuclear phagocyte system and observably inhibited delayed type hypersensitivity.


CONCLUSIONS
TCDCA can significantly enhance the immune function in mice.
Inner Mongolia Agricultural University, Huhehaote.
Xiuling
X
He
Peifeng
P
Li
Hong
H
Guan
Hasisurong
Shaolin
S
Jin
D000818:Animals; D001646:Bile / Q000737:chemistry*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006168:Guinea Pigs; D006460:Hemolysin Proteins / Q000097:blood; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D018655:Lymphocyte Count; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009113:Muramidase / Q000097:blood; D010587:Phagocytosis / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects; D013655:Taurochenodeoxycholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D006460:Hemolysin Proteins; D008419:Materia Medica; D013655:Taurochenodeoxycholic Acid; D009113:Muramidase