Magnetic nanoparticles applied in electrochemical detection of controllable DNA hybridization.
Electrochemical detection of hybridized DNA strands was achieved with a magnetic nanoparticle modified electrode and the commonly used electrochemical couple K3[Fe(CN)6]/K4[Fe(CN)6]. The detection proved to be fast and very simple. Furthermore, magnetic nanoparticles could be employed to control the DNA hybridization process. An inhibited or an enhanced degree of hybridizing could be produced.
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210093 Nanjing, P. R. China.
Xiaoli
X
Zhu
Kun
K
Han
Genxi
G
Li
D001483:Base Sequence; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry; D005295:Ferrocyanides / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry
D005295:Ferrocyanides; D012821:Silanes; D004247:DNA; C031835:potassium ferrocyanide; D052203:Ferrosoferric Oxide