Sparse Bayesian kernel survival analysis for modeling the growth domain of microbial pathogens.
Survival analysis is a branch of statistics concerned with the time elapsing before "failure," with diverse applications in medical statistics and the analysis of the reliability of electrical or mechanical components. We introduce a parametric accelerated life survival analysis model based on kernel learning methods that, at least in principal, is able to learn arbitrary dependencies between a vector of explanatory variables and the scale of the distribution of survival times. The proposed kernel survival analysis method is then used to model the growth domain of Clostridium botulinum, the food processing and storage conditions permitting the growth of this foodborne microbial pathogen, leading to the production of the neurotoxin responsible for botulism. A Bayesian training procedure, based on the evidence framework, is used for model selection and to provide a credible interval on model predictions. The kernel survival analysis models are found to be more accurate than models based on more traditional survival analysis techniques but also suggest a risk assessment of the foodborne botulism hazard would benefit from the collection of additional data.
Cawley
Gavin C
GC
School of Computing Sciences, University of East Anglia, Norwich NR4 7TJ, UK. gcc@cmp.uea.ac.uk
Talbot
Nicola L C
NL
Janacek
Gareth J
GJ
Peck
Michael W
MW
D001185:Artificial Intelligence; D001499:Bayes Theorem; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D003014:Clostridium botulinum / Q000166:cytology* / Q000254:growth & development*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005516:Food Microbiology; D008954:Models, Biological; D015233:Models, Statistical; D011158:Population Growth; D016019:Survival Analysis; D015996:Survival Rate