Alkaloids from the roots of Aconitum pseudo-laeve var. erectum.
One new quinazoline (1) and two new norditerpenoid (2 and 3) alkaloids along with 10 known compounds were isolated from the roots of Aconitum pseudo-laeve var. erectum. The new alkaloids were assigned as 2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoic acid methyl ester (1), 18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyllycoctonine (2), and 14-O-acetyl-8-O-methyl-18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoylcammaconine (3). The structures of the new alkaloids were established by spectroscopic methods. This is the first report of the 2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyl ester group being found as an acyl substituent in norditerpenoid alkaloids (compounds 2 and 3).
Natural Products Research Institute and College of Pharmacy, Seoul National University, Korea.
Sang Hee
SH
Shim
Ju Sun
JS
Kim
Kun Ho
KH
Son
Ki Hwan
KH
Bae
Sam Sik
SS
Kang
D000157:Aconitine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D007723:Korea; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry* / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D011799:Quinazolines; D000157:Aconitine