Generation of cloned transgenic pigs rich in omega-3 fatty acids.
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
Lai
Liangxue
L
Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
Kang
Jing X
JX
Li
Rongfeng
R
Wang
Jingdong
J
Witt
William T
WT
Yong
Hwan Yul
HY
Hao
Yanhong
Y
Wax
David M
DM
Murphy
Clifton N
CN
Rieke
August
A
Samuel
Melissa
M
Linville
Michael L
ML
Korte
Scott W
SW
Evans
Rhobert W
RW
Starzl
Thomas E
TE
Prather
Randall S
RS
Dai
Yifan
Y
D000818:Animals; D030801:Animals, Genetically Modified / Q000378:metabolism*; D017173:Caenorhabditis elegans; D019976:Cloning, Organism / Q000379:methods*; D015525:Fatty Acids, Omega-3 / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008460:Meat / Q000032:analysis; D018482:Muscle, Skeletal / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D013552:Swine / Q000502:physiology*; D014018:Tissue Distribution
D015525:Fatty Acids, Omega-3