Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats.
We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantly lower in ethanol treated rats. Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A:G ratio in serum. Ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.
Maneesh
M
M
Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim. manu_only@hotmail.com
Jayalekshmi
H
H
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy*; D007019:Hypoproteinemia / Q000139:chemically induced* / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D002492:Central Nervous System Depressants; D004151:Dipeptides; D008055:Lipids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D000431:Ethanol; D024502:alpha-Tocopherol; C002939:ornithylaspartate; D001205:Ascorbic Acid