Suspected takotsubo cardiomyopathy caused by withdrawal of bupirenorphine in a child.
A 2-year-old Japanese girl had transient left ventricular apical ballooning on echocardiography and ST-segment elevation and T-wave inversion on electrocardiogram after withdrawal of bupirenorphine and midazolam. The findings improved within 2 weeks. There are many case reports of adults with takotsubo cardiomyopathy but none in children. Takotsubo cardiomyopathy is not well known by pediatric cardiologists, so pediatric cases may have been overlooked. Awareness of a phenomenon similar to takotsubo cardiomyopathy, even in young children, may be important.
Maruyama
Shinsuke
S
Division of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Japan.
Nomura
Yuichi
Y
Fukushige
Toshiro
T
Eguchi
Taisuke
T
Nishi
Jun-Ichiro
J
Yoshinaga
Masao
M
Kawano
Yoshifumi
Y
D000367:Age Factors; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002675:Child, Preschool; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology / Q000503:physiopathology; D008874:Midazolam / Q000008:administration & dosage; D012131:Respiratory Insufficiency / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
D000701:Analgesics, Opioid; D002047:Buprenorphine; D008874:Midazolam