[Biotoxicology and biodynamics of silica nanoparticle].
OBJECTIVE
To investigate the toxicology and biodynamics of silica nanoparticle.


METHODS
The silica nanoparticles were injected into mice through tail vein, and the mice were amphimixised, the urine was collected in different time, variations of pathology in organs and tissues of the mice were detected. At the same time, the silica nanoparticles' distribution in the tissues was observed through electron microscope.


RESULTS
The silica nanoparticles were detected in all tissues and urine of the mice. The injected mice can reproduce as normal.


CONCLUSIONS
The silica nanoparticles do not have toxicity and can be used in vivo.
Xue
Zhi-gang
ZG
National Key Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Zhu
Shai-hong
SH
Pan
Qian
Q
Liang
De-sheng
DS
Li
Yu-mei
YM
Liu
Xiong-hao
XH
Xia
Kun
K
Xia
Jia-hui
JH
D000818:Animals; D005260:Female; D008297:Male; D008422:Materials Testing; D051379:Mice; D049329:Nanostructures / Q000633:toxicity*; D051381:Rats; D012822:Silicon Dioxide / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution; D014162:Transfection
D012822:Silicon Dioxide