Is asthma research in dead end?
Despite enormous therapeutic advances, bronchial asthma remains a highly prevalent and serious health problem. Although we have learnt much about the pathogenesis of asthma and developed some new drugs within the last few years, there is still an urgent need for new treatments. The so-called single mediator approach appears to be ineffective in the treatment of asthma. Drugs with multiple sites of mode of action would have greater chances to be successfully introduced into therapy. The present drug screening strategy should be reconsidered and probably be replaced by new and more serendipity-based research.
Amon
Annette
A
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Fahrstr. 17, 91054 Erlangen, Germany.
Pahl
Andreas
A
Szelenyi
Istvan
I
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D035843:Biomedical Research; D004195:Disease Models, Animal; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans
D018927:Anti-Asthmatic Agents