Nematode neuropeptide receptors and their development as anthelmintic screens.
This review addresses the potential use of neuropeptide receptors for the discovery of anthelmintic agents, and particularly for the identification of non-peptide ligands. It outlines which nematode neuropeptides are known and have been characterized, the published information on drug discovery around these targets, information about existing high- and low-throughput screening systems and finally the likely safety of neuropeptide mimetics.
Greenwood
K
K
Pfizer Animal Health, Ramsgate Road, Sandwich, Kent CT13 9NJ. karen.g.greenwood@pfizer.com
Williams
T
T
Geary
T
T
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D008024:Ligands; D009348:Nematoda / Q000187:drug effects / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009479:Neuropeptides / Q000502:physiology; D018013:Receptors, Neuropeptide / Q000187:drug effects* / Q000378:metabolism*
D000871:Anthelmintics; C029152:G-substrate; D008024:Ligands; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D018013:Receptors, Neuropeptide