[Influence of bisphosphonate treatment on the radiological features of osteogenesis imperfecta in children].
The Osteogenesis imperfecta (OI) is a hereditary disturbance of collagen biosynthesis. The illness is characterized by frequent fractures that consequently cause functional disturbance of locomotion system as well as deformation of long tubular bones. The purpose of the present work was to study radiological features of clinical forms of osteogenesis imperfecta during bisphosphonate treatment in children according to the schemes we developed taking into consideration the type of illness and the age of the patient. The total number of 32 patients, aged 1-15, suffering from osteogenesis imperfecta, have been investigated. The patients have been divided into three groups depending on the type of illness (I, III and IV type). Type II (lethal form) has not been observed by us. All patients, participating in the study underwent radiological examination of tubular bones and vertebra pre and post treatment. The results of the study showed that bisphosphonate treatment has positive effects in patients of type I and IV of osteogenesis imperfecta and is less effective in the type III of the diseases.
Chigladze
T T
TT
Zhvaniia
M A
MA
Bekua
M V
MV
D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010013:Osteogenesis Imperfecta / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D000077268:Pamidronate; D014057:Tomography, X-Ray Computed
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate