Cardioprotective effects of vegetables: is nitrate the answer?
A diet rich in fruits and vegetables is associated with a lower risk of certain forms of cancer and cardiovascular disease, but the mechanisms behind this protection are not completely understood. Recent epidemiological studies suggest a cardioprotective action afforded specifically by green leafy vegetables. We here propose that these beneficial effects are related to the high content of inorganic nitrate, which in concert with symbiotic bacteria in the oral cavity is converted into nitrite, nitric oxide, and secondary reaction products with vasodilating and tissue-protective properties.
Lundberg
Jon O
JO
Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden. jon.lundberg@ki.se
Feelisch
Martin
M
Björne
Håkan
H
Jansson
Emmelie A
EA
Weitzberg
Eddie
E
D002316:Cardiotonic Agents / Q000494:pharmacology*; D006801:Humans; D009566:Nitrates / Q000378:metabolism / Q000502:physiology*; D009569:Nitric Oxide / Q000096:biosynthesis; D009573:Nitrites / Q000378:metabolism; D014675:Vegetables
D002316:Cardiotonic Agents; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide