Nucleosome structure and function.
It is now widely recognized that the packaging of genomic DNA, together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, DNA repair, and recombination. How chromatin structure modulates the expression of knowledge encoded in eukaryotic genomes, and how these processes take place within the context of a highly complex and compacted genomic chromatin environment remains a major unresolved question in biology. Here we review recent advances in nucleosome structure and dynamics.
Chodaparambil
J V
JV
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523-1870, USA.
Edayathumangalam
R S
RS
Bao
Y
Y
Park
Y J
YJ
Luger
K
K
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances / Q000378:metabolism; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000502:physiology; D020836:Protein Structure, Quaternary / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D050436:Regulatory Elements, Transcriptional / Q000235:genetics; D014158:Transcription, Genetic / Q000502:physiology
D006657:Histones; D046911:Macromolecular Substances; D009707:Nucleosomes; D004247:DNA