[Thrombin and angiogenesis of cancer--review].
Thrombin is the most important factor in hemostasis. In recent years, it has been found that thrombin is a potent mitogen capable of inducing cellular functions. Therefore, it is proved to be of importance in promoting the growth, metastasis and angiogenesis of cancer. Anticoagulant therapy not only reduce the characteristic hypercoagulability of cancer, but also inhibits growth and metastasis of cancer, and alters the fundamental biology of cancer. In this paper thrombin and its receptor, relationship of thrombin and its receptor with cancer growth, metastasis and angiogenesis, the mechanisms of thrombin influence on cancer angiogenesis, as well as application prospects on anti-angiogenesis and anti-coagulation therapy were reviewed.
Institute of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Jian-Xia
JX
Shi
Jian
J
Gu
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D000991:Antithrombins / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic; D018179:Receptors, Thrombin / Q000502:physiology*; D013917:Thrombin / Q000502:physiology*
D020533:Angiogenesis Inhibitors; D000925:Anticoagulants; D000991:Antithrombins; D018179:Receptors, Thrombin; D013917:Thrombin