Hemostatic responses to resistance training in patients with coronary artery disease.
OBJECTIVE
This study was undertaken to evaluate changes in coagulation and fibrinolytic responses to an acute bout of resistance training in patients with coronary artery disease.


METHODS
Fourteen low-to-moderate risk men (mean age, 57.6 +/- 9 years; body mass index, 26.7 +/- 4.0 kg/m) with known coronary artery disease participated in this study. All subjects were recruited from the hospital's outpatient cardiac rehabilitation program and none were participating in a resistance training exercise program at the time. Using 8 different resistance training devices, each subject performed 1 set of 10 repetitions to volitional fatigue, resting 1 minute between sets. Blood samples (5 mL) were drawn preexercise, immediate postexercise, and 1 hour postexercise in the seated position. All values were corrected for plasma volume changes. Alterations in von Willebrand Factor antigen, tissue plasminogen activator antigen, and plasminogen activator inhibitor-1 activity were analyzed using repeated measures analysis of variance.


RESULTS
Although von Willebrand Factor antigen remained unchanged from preexercise values, tissue plasminogen activator antigen and plasminogen activator inhibitor-1 activity increased and decreased, respectively, in the immediate postexercise recovery period. Moreover, the latter reduction persisted at 1 hour postexercise.


CONCLUSIONS
An acute bout of resistance training improves fibrinolytic potential in men with coronary artery disease, without elevating thrombotic potential. These data support the safety of resistance training in this population when contemporary prescriptive guidelines are used.
Division of Cardiology, Cardiac Rehabilitation and Exercise Laboratories, William Beaumont Hospital, Royal Oak, MI, USA.
Adam T
AT
deJong
Christopher J
CJ
Womack
Jamie Anderson
JA
Perrine
Barry A
BA
Franklin
D000704:Analysis of Variance; D000941:Antigens / Q000097:blood; D001777:Blood Coagulation; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology* / Q000534:rehabilitation; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; D017395:Plasminogen Activator Inhibitor 1; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D010959:Tissue Plasminogen Activator