A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation.
The acute inflammatory response, triggered by a variety of biological or physical stresses on an organism, is a delicate system of checks and balances that, although aimed at promoting healing and restoring homeostasis, can result in undesired and occasionally lethal physiological responses. In this work, we derive a reduced conceptual model for the acute inflammatory response to infection, built up from consideration of direct interactions of fundamental effectors. We harness this model to explore the importance of dynamic anti-inflammation in promoting resolution of infection and homeostasis. Further, we offer a clinical correlation between model predictions and potential therapeutic interventions based on modulation of immunity by anti-inflammatory agents.
Reynolds
Angela
A
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Rubin
Jonathan
J
Clermont
Gilles
G
Day
Judy
J
Vodovotz
Yoram
Y
Bard Ermentrout
G
G
D000208:Acute Disease; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D018836:Inflammation Mediators / Q000502:physiology; D018448:Models, Immunological; D010586:Phagocytes / Q000502:physiology
D018836:Inflammation Mediators