[Sentinel lymph node dissection in prostate cancer. Experience after more than 800 interventions].
There is no consensus on which prostate cancer patients should undergo lymph node removal and which lymph nodes should be included. Therefore, most clinicians rely on nomograms and dispense with lymph node dissection in patients with low-risk disease. Meanwhile, there are some studies which prove that there are also lymph node metastases in patients with low-risk prostate cancer and that lymph node metastases are predominantly localized outside the region of standard lymphadenectomy. In more than 800 men we could show that lymph node metastases were found more often than shown in the Partin tables. These lymph node metastases were detected by sentinel lymph node dissection outside the region of standard and extended lymphadenectomy. Because of insufficient preoperative diagnostics it is unclear which patients have positive lymph nodes. Therefore, it is useful to perform lymph node dissection in every patient. Men with positive nodes could have a better prognosis, when sentinel and extended lymph node dissection are performed.
Urologische Klinik, Klinikum, Stenglinstrasse 2, 86156, Augsburg. dorothea.weckermann@uro.augsburg-med.de
D
D
Weckermann
M
M
Hamm
R
R
Dorn
T
T
Wagner
F
F
Wawroschek
R
R
Harzmann
D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012669:Seminal Vesicles / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D001743:Urinary Bladder / Q000473:pathology
D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen