[The experimental study of mechanism of integrin in hypertrophic scar contracture].
OBJECTIVE
To study the mechanism of integrin in hypertrophic scar.


METHODS
Fibroblasts from 10 samples of human hypertrophic scars was cultured, FQ-PCR assay was applied to detect mRNA expression of alpha-SMA in hypertrophic scar fibroblasts after integrin and FAK antibody blocking.


RESULTS
mRNA of alpha-SMA in fibroblasts expressed obviously lower after integrin and FAK antibody blocking than that of control groups ( P < 0.05).


CONCLUSIONS
Through accelerating the synthesis of alpha-SMA, integrin and FAK play an important role in contracture of hypertrophic scar.
He
Zheng-yu
ZY
Department of Plastic Surgery, Renji Hospital, SSMV, Shanghai 200127, China.
Hou
Xiao-bing
XB
Fan
Zhi-hong
ZH
D000199:Actins / Q000096:biosynthesis; D000328:Adult; D002478:Cells, Cultured; D017439:Cicatrix, Hypertrophic / Q000378:metabolism* / Q000473:pathology*; D003286:Contracture / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism; D051417:Focal Adhesion Kinase 1 / Q000096:biosynthesis; D006801:Humans; D016023:Integrins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism; D055815:Young Adult
C541116:ACTA2 protein, human; D000199:Actins; D016023:Integrins; D012333:RNA, Messenger; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human