[Progress of research and application on hematopoietic stem cell transplantation by intra-bone marrow injection--review].
The purpose of hematopoietic stem cell transplantation by intra-bone marrow injection (IBM-HSCT) is to facilitate the homing of HSC. It has been recently proven in many animal experiments that different kinds of donor cells could efficiently home and engraft into the bone marrow by IBM-HSCT, which led to the rapid hemopoietic and immune recovery of recipients, preventing the development of GVHD, inducing the donor-specific tolerance in allogeneic organ transplantation, and promoting the survival rate of recipients. In this review, the effect of IBM-BMT and IBM-UCBT, the application of IBM injection technique in the study on HSC's biological characteristics, and its prospect for clinical HSCT were summarized.
Cai
Yun
Y
Department of Pediatrics, The Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, China.
Huang
Shao-Liang
SL
D000818:Animals; D001853:Bone Marrow; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D017148:Infusions, Intraosseous; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods