Advanced oral antibacterial/anti-inflammatory technology: A comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice.
BACKGROUND
Triclosan is a broad-spectrum antibacterial agent, marketed for use in oral products. It is effective against both gram-positive and gram-negative bacteria. PVM/MA is the non-proprietary designation for a polyvinylmethyl ether maleic acid copolymer. It has been demonstrated that there is a greater uptake of triclosan to enamel and buccal epithelial cells from the use of a fluoride dentifrice containing triclosan and the PVM/MA copolymer than from a dentifrice containing triclosan alone. This Supplement details the results of antibacterial, anti-inflammatory, and short- and long-term plaque and gingivitis studies with a triclosan/copolymer/ fluoride dentifrice. Additionally, the Supplement reviews studies on the effect of a triclosan/copolymer/fluoride dentifrice on periodontitis, calculus, caries, whitening and stain removal, oral malodor, and on the microflora.


CONCLUSIONS
Clinical studies indicate that the use of a triclosan/copolymer/fluoride dentifrice (Colgate Total Toothpaste) may provide oral health benefits beyond those associated with "traditional" toothpaste use, in a manner that is safe and effective. Studies presented in this Supplement demonstrate that Colgate Total Toothpaste provides superior protection against plaque and gingivitis, caries, oral malodor, exhibits superior stain removal, and provides protection against the progression of periodontal disease.
Panagakos
Fotinos S
FS
Colgate-Palmolive Technology Center Piscataway, NJ, USA.
Volpe
Anthony R
AR
Petrone
Margaret E
ME
DeVizio
William
W
Davies
Robin M
RM
Proskin
Howard M
HM
D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002986:Clinical Trials as Topic; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003728:Dental Calculus / Q000517:prevention & control; D003731:Dental Caries / Q000517:prevention & control; D003773:Dental Plaque / Q000517:prevention & control; D004338:Drug Combinations; D005459:Fluorides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005891:Gingivitis / Q000517:prevention & control; D006209:Halitosis / Q000517:prevention & control; D006801:Humans; D008298:Maleates / Q000494:pharmacology / Q000627:therapeutic use*; D010518:Periodontitis / Q000517:prevention & control; D011095:Polyethylenes / Q000494:pharmacology / Q000627:therapeutic use*; D012824:Silicic Acid; D014075:Tooth Discoloration / Q000517:prevention & control; D014100:Toothpastes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D045424:Complex Mixtures; D004338:Drug Combinations; D008298:Maleates; D011095:Polyethylenes; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; C043105:poly(methyl vinyl ether-co-maleic anhydride); D005459:Fluorides