Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice.
The present study aimed to investigate the effects of sleep deprivation (SD) on the dose-dependent stimulant effect of ethanol (ETOH) on the open-field behavior of female and male mice. Sleep-deprived (48 h, multiple platforms method) or home-cage control female mice were treated with saline (SAL) or 1.4, 1.8 or 2.2g/kg ETOH 5 min before behavioral testing. ETOH produced a dose-dependent increase in open-field locomotor behavior. This locomotor stimulant effect did not reflect a general stimulation in motor activity, since it was accompanied by a simultaneous decrease in rearing frequency as well as by no modification in immobility duration. The effects of ETOH on these three behavioral parameters were specifically modified by SD: the locomotor stimulant effect was abolished, the rearing inhibitory effect was potentiated and the lack of effect on immobility was changed to increase in immobility. Similar results were obtained for male mice although the effects of SD had a lower magnitude. The present findings demonstrate that the acute effect of ETOH on mice's motor activity are behaviorally complex and can be specifically modulated by SD.
Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, SP 04023-062, Brazil.
Nilza P
NP
Araujo
Monica L
ML
Andersen
Vanessa C
VC
Abílio
Daniele C
DC
Gomes
Rita C
RC
Carvalho
Regina H
RH
Silva
Rosana de A
Rde A
Ribeiro
Sergio
S
Tufik
Roberto
R
Frussa-Filho
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D012892:Sleep Deprivation / Q000503:physiopathology*
D002492:Central Nervous System Depressants; D000431:Ethanol