Suspected takotsubo cardiomyopathy caused by withdrawal of bupirenorphine in a child.
A 2-year-old Japanese girl had transient left ventricular apical ballooning on echocardiography and ST-segment elevation and T-wave inversion on electrocardiogram after withdrawal of bupirenorphine and midazolam. The findings improved within 2 weeks. There are many case reports of adults with takotsubo cardiomyopathy but none in children. Takotsubo cardiomyopathy is not well known by pediatric cardiologists, so pediatric cases may have been overlooked. Awareness of a phenomenon similar to takotsubo cardiomyopathy, even in young children, may be important.
Division of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Japan.
Shinsuke
S
Maruyama
Yuichi
Y
Nomura
Toshiro
T
Fukushige
Taisuke
T
Eguchi
Jun-Ichiro
J
Nishi
Masao
M
Yoshinaga
Yoshifumi
Y
Kawano
D000367:Age Factors; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002675:Child, Preschool; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology / Q000503:physiopathology; D008874:Midazolam / Q000008:administration & dosage; D012131:Respiratory Insufficiency / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
D000701:Analgesics, Opioid; D002047:Buprenorphine; D008874:Midazolam