[Effect of maternal diabetes on human and rat fetal development].
Diabetes is a genetically determined metabolic disease with fasting hyperglycemia due to relative or absolute absence of insulin. With the use of exogenous insulin, successful gestations are now possible. Nevertheless, there are still severe problems associated, such as spontaneous abortion, perinatal mortality and congenital malformations. Caudal regression syndrome, disclosure of the neural tube and cardiovascular alterations are the most common malformations. Gestational diabetes can induce increased fetal corporal fat and macrosomia with hyperinsulinemia, hypoglycemic, hypoxia, metabolic acidosis and perinatal death. During adult life, diabetic mothers' children can develop obesity, glucose intolerance and type 2 diabetes. In order to study fetuses' alterations during diabetic gestations we now have animal models of diabetes. Maternal diabetes in rats alters fetal development in a very similar manner to that of humans. Although we do not accurately know the pathogenic mechanism by which diabetes produces fetuses' abnormal development, hyperglycemia and hyperketonemia had been mentioned to have predominant roles. Hyperglycemia damages DNA and increases oxidative stress and hyperketonemia increases the rate of embryo malformations. The addition of antioxidants such as C and E vitamins can reduce this damage. During adult life, diabetic rats' cubs have alterations in glucose metabolism and in reproductive function. The understanding of mechanisms by which maternal diabetes affects fetuses development, can help us to prevent complications and improve mothers' and children's life quality.
Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social.
Ana Cecilia
AC
Polanco Ponce
María Cristina
MC
Revilla Monsalve
Miguel Angel
MA
Palomino Garibay
Sergio
S
Islas Andrade
D000328:Adult; D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology; D003921:Diabetes Mellitus, Experimental; D016640:Diabetes, Gestational; D004195:Disease Models, Animal; D005260:Female; D047109:Fetal Development; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D051381:Rats