Successful pregnancy following gonadotrophin-releasing hormone analogue treatment in a previously infertile bitch.
A Labrador retriever bitch was presented with repeated unsuccessful breeding during both the third and fourth oestruses, even though accurate timing for natural mating was planned based on the results obtained using a semiquantitative luteinising hormone kit and a quantitative assay of progesterone. To identify the problem, serum luteinising hormone, follicle-stimulating hormone, progesterone, and oestradiol-17beta concentrations around the fourth oestrus stage were assayed by radioimmunoassay. Abnormal luteinising hormone fluctuations were detected during pro-oestrus and oestrus, and lower than normal progesterone concentrations were found during the mating period. In the fifth to seventh oestrus, the bitch was successfully treated with gonadotrophin-releasing hormone analogue at times based on the findings of the hormonal assays.
Tsumagari
S
S
Department of Veterinary Science, Nihon University, Fujisawa-shi, Kanagawa, Japan.
Ishinazaka
T
T
Watanabe
G
G
Taya
K
K
Ishii
M
M
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy / Q000662:veterinary*; D007986:Luteinizing Hormone / Q000097:blood; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011967:Receptors, Gonadotropin; D016896:Treatment Outcome
D011967:Receptors, Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C009936:fertirelin