Intracytoplasmic sperm injection may lead to vertical transmission, expansion, and de novo occurrence of Y-chromosome microdeletions in male fetuses.
Y-chromosome microdeletion in male fetuses conceived by intracytoplasmic sperm injection (ICSI) was screened by polymerase chain reaction for sequence-tagged sites in azoospermia factor (AZF)-b and AZFc regions. Treatment with ICSI may lead to vertical transmission, expansion, and de novo Y-chromosome microdeletion in male fetuses.
Lee
Sook-Hwan
SH
Infertility Medical Center of CHA General Hospital, CHA Research Institute, Seoul, Korea.
Ahn
So-Yeon
SY
Lee
Kyo-Won
KW
Kwack
KyuBum
K
Jun
Hye-Sun
HS
Cha
Kwang-Yul
KY
D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D006801:Humans; D015994:Incidence; D018445:Infectious Disease Transmission, Vertical; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy*; D008297:Male; D009030:Mosaicism; D012737:Sex Factors; D020554:Sperm Injections, Intracytoplasmic