Turning off Smads: identification of a Smad phosphatase.
Although the activation of Smad signaling pathways downstream of TGF-beta superfamily ligands by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphatases that turn off Smad activity. Recently in Genes & Development, describe pyruvate dehydrogenase phosphatase as a Smad1 phosphatase that functions in Drosophila in the Decapentaplegic pathway and in mammalian cells in the BMP pathway.
Hill
Caroline S
CS
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom.
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D051785:Smad Proteins / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D010744:Phosphoric Monoester Hydrolases