New natural urease inhibitors from Ranunculus repens.
Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of Ranunculus repens led to the isolation of methyl 3,4,5-trihydroxybenzoate 1, R(+)- 4-methoxydalbergione 2 and R(+)-dalbergiophenol 3. The structures of these compounds were established through spectral studies including 1D and 2D NMR experiments and by comparison with literature data. These compounds showed potent inhibitory activity against urease.
Khan
Wahib Noor
WN
Department of Chemistry, Gomal University, D I Khan, Pakistan.
Lodhi
Muhammad Arif
MA
Ali
Irshad
I
Azhar-Ul-Haq
Malik
Abdul
A
Bilal
Salma
S
Gul
Rukhsana
R
Choudhary
Muhammad Iqbal
MI
D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D031947:Ranunculus / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors*
D001565:Benzoates; D004791:Enzyme Inhibitors; D010636:Phenols; D010936:Plant Extracts; C408678:methyl 3,4,5-triacetoxybenzoate; D014510:Urease