Congenital indifference to pain and deletion of chromosome 10q-: new association.
We describe a case of a de novo terminal deletion of the long arm of chromosome 10 with the novel feature of congenital indifference to pain in a 2-year 10-month-old boy. Relative indifference to pain defined by a lack of emotional response to pain has not been described previously in association with the terminal deletion of the long arm of chromosome 10.
Department of Pediatrics, University of Manitoba, Winnipeg, Canada. cjoshi@hsc.mb.ca
Charuta
C
Joshi
Angelika J
AJ
Dawson
Shannon R
SR
Sanders
Chitra
C
Prasad
D002675:Child, Preschool; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002658:Developmental Disabilities / Q000175:diagnosis / Q000235:genetics; D004431:Ear, External / Q000002:abnormalities; D004644:Emotions; D004948:Esotropia / Q000175:diagnosis / Q000235:genetics; D005500:Follow-Up Studies; D006801:Humans; D006987:Hypesthesia / Q000175:diagnosis / Q000235:genetics*; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009123:Muscle Hypotonia / Q000175:diagnosis / Q000235:genetics