New potential biologically active compounds: design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation.
A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening.
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Xuzhou, Jiangsu 221009, PR China. laotu2001@263.net
Shujiang
S
Tu
Xiaotong
X
Zhu
Jinpeng
J
Zhang
Jianing
J
Xu
Yan
Y
Zhang
Qian
Q
Wang
Runhong
R
Jia
Bo
B
Jiang
Junyong
J
Zhang
Changsheng
C
Yao
D015195:Drug Design; D006900:Hydroxylation; D008872:Microwaves; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D011804:Quinolines; C037219:quinoline