Amantadine-induced livedo reticularis: a report of two cases.
In the last several years, amantadine has been increasingly prescribed for akinesia in Parkinson's disease and to combat fatigue associated with multiple sclerosis. Amantadine is a well-known medication involved in drug-induced livedo reticularis (LR), yet remains under-reported in the English literature. We describe 2 patients with amantadine livedo reticularis: one patient with multiple sclerosis had, previous to this eruption, tolerated 4 years of amantadine therapy without adverse reactions and another patient with Parkinson's disease who developed LR 1 month after starting amantadine.
Vanderbilt University Medical Center, Division of Dermatology, Nashville, TN, USA.
Benjamin B
BB
Hayes
Robert H
RH
Cook-Norris
Jami L
JL
Miller
Adrian
A
Rodriguez
John A
JA
Zic
D000368:Aged; D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007866:Leg; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy; D010300:Parkinson Disease / Q000188:drug therapy; D017445:Skin Diseases, Vascular / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology
D000978:Antiparkinson Agents; D000547:Amantadine