Intracranial aspergillosis in children successfully treated with antifungal therapy and surgical intervention.
Invasive aspergillosis is an uncommon but often lethal complication in immunocompromised patients. Despite the progress obtained with new antifungal drugs, intracranial aspergillosis often requires a combined medical and surgical approach. Most cases previously reported in immunocompromised children were fatal. We describe 4 immunosuppressed children with intracranial aspergillosis successfully treated with surgery and antifungal long-term therapy.
Giacchino
Mareva
M
Department of Infectious Diseases, Immuno-Rheumatology and Onco-Hematology, University of Turin, Italy. mareva.giacchino@unito.it
Chiapello
Nadia
N
Riva
Caterina
C
Scolfaro
Carlo
C
Pultrone
Mirco
M
Valera
Mariangela
M
Peretta
Paola
P
Piglione
Matilde
M
Di Rosa
Gianpaolo
G
Tovo
Pier-Angelo
PA
D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D000935:Antifungal Agents