Low immunologic response to highly active antiretroviral therapy in naive vertically human immunodeficiency virus type 1-infected children with severe immunodeficiency.
We conducted a retrospective study to analyze the CD4 recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4 of <15% did not reach a mean CD4 of > or =25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4.
Resino
Salvador
S
Laboratorio de Inmuno-Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain. sresino.hgugm@salud.madrid.org
Alvaro-Meca
Alejandro
A
de José
Maria Isabel
MI
Martin-Fontelos
Pablo
P
Gutiérrez
Maria Dolores Gurbindo
MD
Léon
Juan Antonio
JA
Ramos
José Tomás
JT
Ciria
Luis
L
Muñoz-Fernández
Maria Angeles
MA
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D019562:Viral Load