Progressive symptoms and signs following institution of highly active antiretroviral therapy and subsequent antituberculosis therapy: immune reconstitution syndrome or infection?
A 36 year old man presented with weight loss, cough, fever, and exertional dyspnoea shortly after a diagnosis of HIV infection. Symptoms and initial radiological abnormalities worsened after highly active antiretroviral therapy was started. An eventual diagnosis was established but multiple problems occurred throughout the treatment period. Differentiation between immune reconstitution inflammatory syndrome and an infective cause was problematic.
Miller
R F
RF
Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, Mortimer Market Centre, off Capper Street, London WC1E 6AU, UK. rmiller@gum.ucl.ac.uk
Shahmanesh
M
M
Talbot
M D
MD
Wiselka
M J
MJ
Shaw
P J
PJ
Bacon
C
C
Robertson
C M
CM
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D007154:Immune System Diseases / Q000139:chemically induced*; D008297:Male; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology
D000995:Antitubercular Agents