[Assessment of free radical formation process in rats with different audiogenic seizure susceptibility by means of biochemiluminiscent methods].
Complex investigation of free radical process intensity by means of spontaneous, Fe(2+)- and H2O2-induced, luminol dependent biochemiluminescent methods was performed. The increased formation of reactive oxygen species and no change of hydroperoxide levels were found in brain of rats with high seizure susceptibility.
L D
LD
Popova
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005296:Ferrous Compounds / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology
D005296:Ferrous Compounds; D005609:Free Radicals; C020748:ferrous sulfate; D006861:Hydrogen Peroxide