[Pharmacodynamic study of Relinqing granules on bacterial pyelonephritis model in rats].
OBJECTIVE
To observe the effects of Relinqing granules (powder of Polygonum capitatum extract) on the bacterial pyelonephritis model in rats.


METHODS
The rat bacterial pyelonephritis model was induced by injecting the escherichia coli ATCC-25922 into kidney parenchyma. The rats were divided ramdamly into Relinqing groups(52.32, 26.16 g x kg(-1)), norflorin group (0.03 g x kg(-1)), model group and normal control group, and were given experimental drugs by gastrogavage. The contents of leucocytes (WBC), occult bloo (BLD), glucose (GLU), protein (PRO), ketones, bilirubin and urobilinagen in urine were determined.


RESULTS
As compared with the model group, Relinqing granules 6.0 g x kg(-1) (crude drug 52.32 g x kg(-1)) could decrease significantly the contents of WBC and BLD in urine and, however, had no markedly effects on the other biochemical parameters of urine.


CONCLUSIONS
Relinqqing granule has significant effects of decreasing urine WBC and BLD on the bacterial pyolonephritis in rats.
Guizhou Weimen Pharmaceutical Co. Ltd, Guiyang 550018, China.
Meng-Lin
ML
Li
Bin
B
Liang
Jing-Wen
JW
Tang
Yu
Y
Xie
Ai-Ping
AP
Zuo
Feng
F
Du
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000302:isolation & purification / Q000494:pharmacology*; D001663:Bilirubin / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004927:Escherichia coli Infections / Q000652:urine*; D005260:Female; D006029:Glycosuria / Q000652:urine; D007659:Ketones / Q000652:urine; D007958:Leukocyte Count; D008297:Male; D009780:Occult Blood; D010946:Plants, Medicinal / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry; D011507:Proteinuria / Q000652:urine; D011704:Pyelonephritis / Q000652:urine*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000892:Anti-Infective Agents, Urinary; D004365:Drugs, Chinese Herbal; D007659:Ketones; D001663:Bilirubin