Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla.
A new sequence is presented that combines constant-time point-resolved spectroscopy (CT-PRESS) with fast spiral chemical shift imaging. It allows the acquisition of multivoxel spectra without line splitting with a minimum total measurement time of less than 5 min for a field of view of 24 cm and a nominal 1.5x1.5-cm2 in-plane resolution. Measurements were performed with 17 CS encoding steps in t1 (Deltat1=12.8 ms) and an average echo time of 151 ms, which was determined by simulating the CT-PRESS experiment for the spin systems of glutamate (Glu) and myo-inositol (mI). Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner.
Mayer
Dirk
D
Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305-5488, USA. dirk.mayer@stanford.edu
Kim
Dong-Hyun
DH
Adalsteinsson
Elfar
E
Spielman
Daniel M
DM
D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D009419:Nerve Tissue Proteins / Q000032:analysis*; D018377:Neurotransmitter Agents / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents