Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis.
In vivo magnetic resonance techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy have been some of the most useful tools for evaluation of neurologic diseases. In subacute sclerosing panencephalitis, magnetic resonance spectroscopy can be an additional tool for evaluation of disease progression or the efficacy of the treatment, such as interferon or inosiplex, compared with MRI. Inosiplex is one of the effective drugs for subacute sclerosing panencephalitis, but our in vivo and in vitro magnetic resonance spectroscopic study indicated that inosiplex affects the spectra, suggesting a possible failure of neurologic evaluation in a patient with subacute sclerosing panencephalitis treated with inosiplex.
Department of Pediatrics, Gifu University, Japan. zen-k@cc.gifu-u.ac.jp
Zenichiro
Z
Kato
Takahiko
T
Asano
Naomi
N
Kondo
D000293:Adolescent; D000998:Antiviral Agents / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D016477:Artifacts; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007542:Inosine Pranobex / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D007294:Inositol / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009460:Neurologic Examination / Q000187:drug effects; D015203:Reproducibility of Results; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000998:Antiviral Agents; D001224:Aspartic Acid; D019344:Lactic Acid; D007294:Inositol; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D002794:Choline; D007542:Inosine Pranobex