[Reduced post-partum bleeding after treatment with sublingual misoprostol: a randomized double-blind clinical study in a developing country--secondary publication)].
Post-partum haemorrhage is the most common cause of maternal death in third-world countries. The objective of this study was to evaluate whether routine administration of sublingual misoprostol, 600 g, reduces post-partum haemorrhage. Significantly fewer women in the misoprostol group experienced a loss of > or = 1,000 ml (11% vs. 17%; 0.66 (0.45-0.98)) or > or = 1,500 ml (2% vs. 8%; 0.28 (0.12-0.64)) of blood. We conclude that sublingual misoprostol reduces the frequency of severe post-partum haemorrhage.
Nielsen
Birgitte Bruun
BB
Arhus Universitetshospital, Skejby Sygehus, Gynaekologisk-obstetrisk Afdeling Y, og Statens Serum Institut, Afdelingen for Epidemiologisk Forskning. birgitte.bruun.nielsen@dadlnet.dk
Høj
Lars
L
Hvidman
Lone Egly
LE
Nielsen
Jens
J
Cardoso
Placido
P
Aaby
Peter
P
D000286:Administration, Sublingual; D003906:Developing Countries; D004311:Double-Blind Method; D005260:Female; D006169:Guinea-Bissau; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy; D013607:Tablets
D010120:Oxytocics; D013607:Tablets; D016595:Misoprostol