Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
As part of a study on potential antitumor agents from rainforest plants, two new pterocarpans, rautandiol A (1) and rautandiol B (2), together with eight known compounds, were isolated from Neorautanenia mitis. Among the compounds isolated, rotenone (3) and 12-hydroxyrotenone (4) showed significant cytotoxic activity with IC(50) values of 0.008-0.010 and 0.04-0.06 microg/mL against MCF-7 and A-549 cells, respectively.
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, 27599, USA.
Yojiro
Y
Sakurai
Nobuko
N
Sakurai
Masahiko
M
Taniguchi
Yuka
Y
Nakanishi
Kenneth F
KF
Bastow
Xihong
X
Wang
Gordon M
GM
Cragg
Kuo-Hsiung
KH
Lee
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013636:Tanzania; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D036343:Pterocarpans; C510035:rautandiol A; C510036:rautandiol B