[Morphology of drug induced liver damage].
Hepatotoxicity is a significant complication of therapeutic drug use. As ist can imitate nearly all hepatopathies, the diagnosis of drug-induced liver disease is difficult. Most often, it is a diagnosis of exclusion. The following morphological changes are known, dependent on the target cell type: acute and chronic hepatitis, granuloma formation, and fatty liver disease, cholestatic type acute and chronic liver damage with or without inflammation,or mixed forms of liver injury. Portal or perisinusoidal fibrosis can occur following each type of liver damage. Vascular changes or neoplasms are rare. Drug induced liver injuries are more likely induced by type B damage, which is not expected and cannot be reproduced in animal testing. Type A damage, which is known from toxicity assays, is less likely. A specific therapeutic regime is not available. Therefore, early recognition and cessation of the use of the drug is necessary.
Kasper
H-U
HU
Institut für Pathologie am Clemenshospital, Medical-Center-Düesbergweg 128, 48153, Münster, and Institut für Pathologie, Universität zu Köln, Germany. kasper@patho-muenster.de
Drebber
U
U
Hirsch
I
I
Dienes
H P
HP
D000208:Acute Disease; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000473:pathology*; D002908:Chronic Disease; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*