Surfing on prothymosin alpha proliferation and anti-apoptotic properties.
Prothymosin alpha is an extremely abundant nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation that has been recently suggested as an anti- apoptotic factor. Similarly to other oncoproteins, prothymosin alpha is overexpressed in a variety of cancer tissues and cell lines. The present review highlights on the proliferation and anti-apoptotic properties of prothymosin alpha and its possible role in cancer development.
Second Department of Cardiology, Evangelismos General Hospital of Athens, 10676 Athens, Greece. k.letsas@mail.gr
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Letsas
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Frangou-Lazaridis
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011498:Protein Precursors / Q000378:metabolism*; D013947:Thymosin / Q000031:analogs & derivatives* / Q000378:metabolism
D011498:Protein Precursors; C040782:prothymosin alpha; D013947:Thymosin