The ins and outs of iron homeostasis.
Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.
Donovan
Adriana
A
Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Roy
Cindy N
CN
Andrews
Nancy C
NC
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D027682:Cation Transport Proteins / Q000502:physiology; D064451:Hepcidins; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000209:etiology / Q000503:physiopathology; D019190:Iron Overload / Q000209:etiology / Q000503:physiopathology; D035925:Iron-Regulatory Proteins / Q000502:physiology; D000098742:Ferroportin
D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D064451:Hepcidins; D035925:Iron-Regulatory Proteins; D000098742:Ferroportin; D007501:Iron