Cutaneous hypersensitivity reactions to freshwater cyanobacteria--human volunteer studies.
BACKGROUND
Pruritic skin rashes associated with exposure to freshwater cyanobacteria are infrequently reported in the medical and scientific literature, mostly as anecdotal and case reports. Diagnostic dermatological investigations in humans are also infrequently described. We sought to conduct a pilot volunteer study to explore the potential for cyanobacteria to elicit hypersensitivity reactions.


METHODS
A consecutive series of adult patients presenting for diagnostic skin patch testing at a hospital outpatient clinic were invited to participate. A convenience sample of volunteers matched for age and sex was also enrolled. Patches containing aqueous suspensions of various cyanobacteria at three concentrations were applied for 48 hours; dermatological assessment was made 48 hours and 96 hours after application.


RESULTS
20 outpatients and 19 reference subjects were recruited into the study. A single outpatient produced unequivocal reactions to several cyanobacteria suspensions; this subject was also the only one of the outpatient group with a diagnosis of atopic dermatitis. No subjects in the reference group developed clinically detectable skin reactions to cyanobacteria.


CONCLUSIONS
This preliminary clinical study demonstrates that hypersensitivity reactions to cyanobacteria appear to be infrequent in both the general and dermatological outpatient populations. As cyanobacteria are widely distributed in aquatic environments, a better appreciation of risk factors, particularly with respect to allergic predisposition, may help to refine health advice given to people engaging in recreational activities where nuisance cyanobacteria are a problem.
Stewart
Ian
I
National Research Centre for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains, QLD 4108, Australia. i.stewart@uq.edu.au
Robertson
Ivan M
IM
Webb
Penelope M
PM
Schluter
Philip J
PJ
Shaw
Glen R
GR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens; D000818:Animals; D048408:Chlorella vulgaris; D000458:Cyanobacteria / Q000145:classification / Q000472:pathogenicity*; D003603:Cytotoxins / Q000008:administration & dosage*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000382:microbiology*; D005260:Female; D005618:Fresh Water / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010865:Pilot Projects
D000485:Allergens; D003603:Cytotoxins