Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum.
A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2beta,15alpha,20alpha-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2beta-O-(2'-angelate)-beta-D-glucopyranoside, on the basis of spectroscopic analysis ((1)H NMR, (13)C NMR, HMQC, HMBC, NOESY), and was confirmed by X-ray crystallographic analysis. Sylviside (1) displayed weak cytotoxicity against HeLa WT (human epitheloid cervical carcinoma) cells and was also evaluated for its effects on reversing multidrug resistance in HeLa cells overexpressing MDR1.
Konopleva
Mira M
MM
Department of Pharmacognosy and Botany, Vitebsk State University, Republic of Belarus.
Matławska
Irena
I
Wojcińska
Małgorzata
M
Ahmed
Ahmed A
AA
Rybczyńska
Maria
M
Paszel
Anna
A
Ohta
Shinji
S
Hirata
Toshifumi
T
Bylka
Wiesława
W
Mabry
Tom J
TJ
Cannon
John F
JF
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D019450:Genes, MDR / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036622:Gnaphalium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D002094:Republic of Belarus
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005960:Glucosides; C509938:sylviside