Thermodynamic study on antibacterial effect of different extracts from Radix Isatis.
OBJECTIVE
To study and analyze the antibacterial effects of different extracts from Radix Isatis.


METHODS
Staphylococcus aureus was used as the studied object in the experiment. Antibacterial effects of extracts from Radix Isatis were observed by thermocalrimetry on Staphylococcus aureus, together with common pharmacological experiments.


RESULTS
The total extract, ethyl acetate (EtOAc) extract, n-butylalcohol (nBuOH) extract, chloroform (CHCl(3)) extract and petroleum (P.E.) extract had antiviral effects to some extent while the residue after extracting had no antibacterial activity. The potency of antiviral activity among them was as follows: nBuOH extract > EtOAc extract > CHCl(3) extract > total extract > P.E. extract.


CONCLUSIONS
The antibacteriall effects of Radix Isatis were not limited to any active portion, showing that Radix Isatis exerts its antibacterial effects by cooperation of different active fractions in varied ways.
Institute of Chinese Materia Medica, The 302 Hospital of PLA, Beijing 100039. zhao2855@263.net
Yan-ling
YL
Zhao
Fen
F
Qu
Xiao-he
XH
Xiao
Qing-wen
QW
Liao
Jia-bo
JB
Wang
Yong-gang
YG
Ma
Yu-qi
YQ
Sun
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002151:Calorimetry; D031219:Isatis; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D010936:Plant Extracts