[Central-venous-catheter-related bacteremia in neonatalogy].
OBJECTIVE
The aim of this retrospective study was to identify the risk factors for catheter-associated bloodstream infection (CABSI) in neonates.


RESULTS
Fifteen episodes of CABSI occurred in 108 central catheters over a period of one year (2002). The univariate analysis risk factors were birth weight (1.064 vs 1.413 g; P<0.001), gestation age (28 vs 31 weeks; P<0.001), blood transfusion (8/15 vs 3/34; P<0.01), corticosteroids (7/15 vs 3/34; P<0.01), nasal CPAP duration (13.6 vs 2 days; P<0.01). Nasal CPAP duration was the only risk factor independently associated with CASBI (OR=1.2, 95% confidence interval=1.09-1.5) in the multivariate logistic regression analysis.


CONCLUSIONS
The risk of infection associated with low birth weight is multifactorial suggesting that host-related factors are important. Prevention remains difficult and a policy of strict aseptic catheter care must be promoted.
Laboratoire de Bactériologie-Virologie-Hygiène, CHU d'Angers, 49033 Angers cedex 01, France. calemarie@chu-angers.fr
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Lemarié
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Savagner
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Leboucher
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Le Bouedec
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Six
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Branger
D000328:Adult; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology*; D001724:Birth Weight; D001803:Blood Transfusion / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D045422:Continuous Positive Airway Pressure; D004198:Disease Susceptibility; D004866:Equipment Contamination; D005260:Female; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000209:etiology*; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D015993:Life Tables; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis