[The preotective effects of total glycosides Rubus parviflolius on cerebral ischemic in rat].
OBJECTIVE
To observe the protective effects of total glycosides Rubus parviflolius (TGRP) on local cerebral ischemic.


METHODS
The local cerebral ischemia in rat was made by middle cerebral artery occlusion(MACO). The infraction weight was determined by TTC stain. SOD, MDA, GSH and apoptotis were determined with different method respectively.


RESULTS
TGRP 20, 10 mg x kg(-1) ig markedly improved the abnormal nervous symptoms, incredsed the SOD, GSH activity and reduced contentes of MDA in brain of MACO rat, TGRP 20 mg x kg(-1) ig significantly decreased the numbers of apoptotic cells in ischemic cortex.


CONCLUSIONS
TGRP has protective effects against cerebral infraction, and its mechanism may be related to anti-apoptotis and free radical.
Wang
Ji-Sheng
JS
Department of Pharmacy, Chongqing University of Medical Science, Chongqing 400016, China.
Qiu
Zong-Yin
ZY
Xia
Yong-Peng
YP
Li
Hui-Zhi
HZ
Ren
Ling-Yan
LY
Zhang
Li
L
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry
D006027:Glycosides; D018696:Neuroprotective Agents