Diagnostic and surgical approaches in hilar cholangiocarcinoma.
Hilar cholangiocarcinoma is a rare tumor. Surgery remains the only treatment to prolong survival. There is a correlation between the extent of diagnostic work-up and the achieved resection rates. Moreover, diagnostic work-up may contribute to an improvement of the surgical technique. Due to the perihilar fibrosis, the extent of the central lesion may be overestimated, which may lead to exclude the patient from potentially curative surgery. En bloc resection is requested to achieve tumor-free resection margins. The prognosis of the patients treated with surgery is strongly influenced by negative resection margins. According to our experience, 5-year survival of 78/111 patients with tumor resection (resection rate 71%) has been 30%. Forty-eight percent of the patients with curative en bloc resection of tumor and liver survived for more than 5 years. Perioperative mortality was 5.1%. The available data are supposed to reflect the results of centers with high caseload and not the general situation.
Otto
Gerd
G
Department of Transplantation and Hepatobiliopancreatic Surgery, Johannes Gutenberg University Mainz, Langenbeckst. 1, 55101 Mainz, Germany. otto@transplantation.klinik.uni-mainz.de
D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000033:anatomy & histology; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D009367:Neoplasm Staging; D010166:Palliative Care; D011379:Prognosis; D016019:Survival Analysis