Chordoid meningiomas of a different histopathological pattern: a report of two cases.
Chordoid meningioma is an uncommon histopathological variant of meningioma with a peculiar chordoma-like appearance. Its association with systemic inflammatory disorder linked to Castleman's syndrome was confirmed in the majority of young patients, however such a relationship in adults remains enigmatic. We report two cases of chordoid meningiomas in adult patients without manifestation of Castleman's syndrome. One tumour was almost totally composed of chordoma-like areas whereas the second one exhibited the unique combination of chordoma- and chondroma-like pattern. This is the first description of chordoid meningioma combined with extensive cartilaginous metaplasia. Both tumours exhibited histological evidence of infiltrative growth, accompanied by a relatively high proliferative index within structures of chordoid appearance. The designation of the chordoid component in meningioma is very important as this subtype of meningioma exhibits a more aggressive biological behaviour and higher risk of recurrence.
Department of Experimanetal and Clinical Neuropathology, Medical Research Centre, Polish Academy of Science, 5 Pawińskiego Str, 02-106 Warsaw, Poland. matyja@cmdik.pan.pl
Ewa
E
Matyja
Wiesława
W
Grajkowska
Marzena
M
Lazarczyk
Andrzej
A
Marchel
Tomasz
T
Czernicki
D002356:Cartilage / Q000473:pathology; D005871:Castleman Disease / Q000150:complications; D002817:Chordoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008679:Metaplasia; D008875:Middle Aged