Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases.
Increasing emphasis is being placed on biomarkers as indicators of disease states in patients with autoimmune and inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. Careful description of the expression of cell-surface markers and cytokines produced by T and B lymphocytes can lead to a more complete characterization of disease activity in patient populations, and serve as an indicator of the patient's response to therapy.
O'Hara
Richard M
RM
Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA. rohara@wyeth.com
Benoit
Stephen E
SE
Groves
Christopher J
CJ
Collins
Mary
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D016207:Cytokines; D011956:Receptors, Cell Surface