[The role of lipid peroxidation and antioxidant defence system of the kidneys in the predisposition to gentamicin-induced nephrotoxicity in rabbits].
A correlation is established between individual features of the lipid peroxidation processes and the state of the system of antioxidant protection of the kidney in intact rabbits and their susceptibility to gentamicin nephrotoxicity. The level of gentamicin-induced damage of the kidney is more significant in rabbits with increased concentration of malonic dialdehyde in the kidney, which is generated by a NADPH-dependent enzyme system. A decreased level of reduced glutathione, as well as the enzymopathy with respect to superoxide dismutase and catalase are among the factors aggravating gentamicin-induced kidney lesion.
Bushma
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005839:Gentamicins; D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione