Hypertonic NaCl infusions affect milk composition in goats.
The capability of goats to maintain milk production during water deprivation is remarkable and not yet fully understood. The aim of the present study was to investigate whether intravenous infusions of hypertonic NaCl cause release of both vasopressin and oxytocin and whether the peptides, in combination with the hyperosmolality, affect milk flow and milk composition. Six Swedish domestic landrace goats in their first to third lactation were milked every 30 min during experiments. Hypertonic NaCl (HNaCl) or isotonic NaCl (IsoNaCl) were infused for 90 min. Goats were not allowed to drink during infusions. Plasma vasopressin concentration increased during HNaCl infusions, and did not change in response to IsoNaCl infusions. Plasma oxytocin concentration did not change during either infusion. Milk flow was maintained during the infusions. Milk fat concentration decreased in the three samples taken before onset of the infusions, but then increased gradually during HNaCl infusions, while it continued to fall during the IsoNaCl infusions. Milk osmolality followed the rise in plasma osmolality during the HNaCl infusions and did not change in IsoNaCl experiments. Milk lactose concentration increased throughout both series of experiments, the concentration being higher during HNaCl infusions. Milk protein concentration did not change during HNaCl infusions, but fell in the IsoNaCl experiments. It is concluded that the hyperosmolality in combination with elevated plasma vasopressin levels did not disturb the secretory activity of the mammary cells, but rather facilitated emptying of the alveolar milk. Such a mechanism may help to explain the sustained milk production in water deprived goats.
Department of Anatomy and Physiology, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. kerstin.olsson@afys.slu.se
Kerstin
K
Olsson
Urge
U
Mengistu
Jennie
J
Stein
Tafesse
T
Bekele
Rupert M
RM
Bruckmaier
D000818:Animals; D005223:Fats / Q000032:analysis; D005260:Female; D006041:Goats / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D006982:Hypertonic Solutions / Q000494:pharmacology; D007262:Infusions, Intravenous / Q000662:veterinary; D007552:Isotonic Solutions / Q000494:pharmacology; D007774:Lactation / Q000187:drug effects / Q000502:physiology*; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D008894:Milk Proteins / Q000032:analysis; D009994:Osmolar Concentration; D010121:Oxytocin / Q000097:blood* / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors; D014667:Vasopressins / Q000097:blood* / Q000187:drug effects
D005223:Fats; D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D008894:Milk Proteins; D014667:Vasopressins; D012965:Sodium Chloride; D010121:Oxytocin