Gender-related response of lipid metabolism to dietary fatty acids in the hamster.
Gender and dietary fatty acids are involved in the regulation of lipid metabolism, disturbances of which can lead to pathologies such as metabolic syndrome or CVD. Possible interactions between these factors were investigated in male and female hamsters fed diets rich in either saturated fatty acids ( "butter" diet) or in alpha-linolenic acid ( "linseed oil" diet). Gender effect predominated over the diet effect on cholesterol (CH) metabolism; compared to males, females exhibited lower concentrations of plasma total CH (-20 %, P<0.001), LDL-CH (-40 %, P<0.001) and HDL-CH (-16 %, P<0.001), together with higher LDL receptor (+40 %) and lower HDL receptor (-60 %) hepatic content. Triacylglycerol (TG) metabolism was affected by diet above all: compared to animals fed the "butter" diet, those fed the "linseed oil" diet exhibited lower plasma (-23 %, P=0.046) and liver TG (-20 %, P=0.026) concentration which may result from both an increased beta-oxidation (P<0.001), without any change in PPARalpha mRNA, and a decreased hepatic lipogenesis (P=0.023), without increased sterol response element binding protein 1c (SREBP1c) mRNA. The response to diet was much more pronounced in males than in females, without gender effect on the transcription level of PPARalpha and SREBP1c. Finally, the "linseed oil" diet decreased the insulin resistance index (-80 %, P<0.001) with a more marked effect in males, in relation to their higher hepatic PPARgamma expression (+90 %, P=0.012). In conclusion, in our model, the response of either TG or CH to dietary fatty acids is modulated differently by gender. The possible relevance of these interactions to dietary practice should be taken into account in man.
Laboratoire d'Endocrinologie de la Nutrition, Université Paris Sud, 91405 Orsay Cedex, France.
Anne
A
Morise
Jacques
J
Mourot
Carole
C
Boué
Nicole
N
Combe
Ghislaine
G
Amsler
Daniel
D
Gripois
Annie
A
Quignard-Boulangé
Laurent
L
Yvan-Charvet
Evelyne
E
Fénart
Pierre
P
Weill
Dominique
D
Hermier
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D004041:Dietary Fats / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D008043:Linseed Oil / Q000494:pharmacology; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D010084:Oxidation-Reduction; D018110:Receptors, Lipoprotein / Q000378:metabolism; D012737:Sex Factors; D014280:Triglycerides / Q000378:metabolism; D015430:Weight Gain
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D018110:Receptors, Lipoprotein; D014280:Triglycerides; D008043:Linseed Oil; D002784:Cholesterol