Topographical distribution of typical unifocal congenital hypertrophy of retinal pigment epithelium.
OBJECTIVE
To describe the topographical distribution of typical congenital hypertrophy of retinal pigment epithelium (CHRPE) lesions in the ocular fundi.


METHODS
Retrospective review of the clinical records of 52 patients with typical unifocal CHRPE.


RESULTS
The 52 CHRPE lesions ranged from 2.5 mm to 11.5 mm in maximal basal diameter (mean=6.6 mm, SD=2.6 mm). The central point of the lesion was in the peripheral fundus in 44 eyes and in the intermediate fundus in eight eyes. The footprint of the lesion involved the peripheral fundus only in 25 eyes, both the intermediate and peripheral fundus in 22 eyes, and the intermediate fundus only in five eyes. The central point of the lesion was located in the temporal quadrant in 24 eyes, the inferior quadrant in 12 eyes, the nasal quadrant in nine eyes, and the superior quadrant in seven eyes. No lesion in this series involved the posterior fundus.


CONCLUSIONS
The most common fundus location for typical unifocal CHRPE in this series was the peripheral fundus temporally. Although posterior fundus location of CHRPE has been reported occasionally, our study suggests that such a location is very uncommon.
Department of Ophthalmology, University of Cincinnati College of Medicine, 3223 Eden Avenue, Suite 350, Cincinnati, OH 45267-0527, USA. augsbujj@uc.edu
James J
JJ
Augsburger
Ginger L
GL
Henson
Vrinda S
VS
Hershberger
Nikolaos
N
Trichopoulos
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000151:congenital; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012164:Retinal Diseases / Q000151:congenital* / Q000175:diagnosis*; D012189:Retrospective Studies