[Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil].
OBJECTIVE
To explore the effect of intralesional injection of low concentration 5-fluorouracil (5-FU) on inhibition of angiogenesis of keloid.


METHODS
35 patients with 51 keloids were treated with intralesional injection of 5-FU (2-5 mg/ml) biweekly. After 3-6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months.


RESULTS
The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77%. For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14%. Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission.


CONCLUSIONS
Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Xiao-li
XL
Wu
Wei
W
Liu
Yi-lin
YL
Cao
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D006965:Hyperplasia; D007627:Keloid / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D005472:Fluorouracil