HLA-E and immunobiology of pregnancy.
Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons.
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradhesh, India.
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Tripathi
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Naik
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Agrawal
D000026:Abortion, Habitual / Q000235:genetics / Q000276:immunology*; D000483:Alleles; D003062:Codon; D005091:Exons; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism; D054340:Receptors, KIR; D000097625:HLA-E Antigens
D003062:Codon; D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D000097625:HLA-E Antigens