A facile and efficient direct aldol addition of simple thioesters.
[reaction: see text] Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr(2).OEt(2) and i-Pr(2)NEt using untreated, reagent-grade CH(2)Cl(2) under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.
Department of Chemistry and the Center for Chemical Biology, Duke University, Durham, North Carolina 27708, USA.
Julianne M
JM
Yost
Guoqiang
G
Zhou
Don M
DM
Coltart