Looking for food in all the right places?
Examining a potential functional role for growth hormone secretagogue receptors in the hippocampus, Diano and colleagues (Diano et al., 2006), demonstrate novel actions of the orexigenic peptide ghrelin in hippocampal synaptic architecture, LTP, and learning and memory. These data suggest functional links between metabolic signaling and higher neural function.
Moran
Timothy H
TH
Departments of Psychiatry and Behavioral Sciences and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Gao
Su
S
D054369:Agouti-Related Protein; D000818:Animals; D001522:Behavior, Animal; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism; D005247:Feeding Behavior; D054439:Ghrelin; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D007858:Learning / Q000502:physiology*; D020738:Leptin / Q000502:physiology; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D009478:Neuropeptide Y / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D064446:Orexin Receptors; D000068797:Orexins; D036361:Peptide Hormones / Q000494:pharmacology / Q000502:physiology*; D011333:Pro-Opiomelanocortin / Q000502:physiology; D011506:Proteins / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; D011986:Receptors, Somatotropin / Q000502:physiology*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
D054369:Agouti-Related Protein; D054439:Ghrelin; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009478:Neuropeptide Y; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D036361:Peptide Hormones; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; D011986:Receptors, Somatotropin; D011333:Pro-Opiomelanocortin