Preterm delivery of a first child and subsequent mothers' risk of ischaemic heart disease: a nested case-control study.
Several studies have suggested that preterm delivery is related to a risk of subsequent ischaemic heart disease (IHD) in the mother. We conducted a nested case-control study in the E3N cohort to assess the association between preterm delivery of a first child and IHD, and the effect of major cardiovascular risk factors on this association. The study included 109 cases and 395 controls. Mothers who had preterm delivery were at an increased risk of IHD [multivariate hazard ratio 2.09 (95% confidence interval 1.07-4.09)]. This association was independent of major cardiovascular risk factors.
INSERM U258, Epidémiologie Cardiovasculaire et Métabolique, Hôpital Paul Brousse, 16 Avenue Paul Vaillant, Couturier 94805, Villejuif, France. oliver.nardi@libertysurf.fr
Olivier
O
Nardi
Mahmoud
M
Zureik
Dominique
D
Courbon
Pierre
P
Ducimetière
Françoise
F
Clavel-Chapelon
D016022:Case-Control Studies; D005260:Female; D005602:France; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D017202:Myocardial Ischemia / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors