Primary cutaneous nodular amyloidosis in a patient with Sjögren's syndrome.
A 71-year-old woman with a history of Sjögren's syndrome presented for evaluation of a waxy nodule present on the scalp for 6 months. Histopathologic examination revealed deposition of homogenous eosinophilic material throughout the reticular dermis consistent with amyloidosis. Primary cutaneous nodular amyloidosis is a rare phenomenon characterized by the deposition of immunoglobin light chains by a clonal plasma cell population. Patients need to be monitored for progression to systemic amyloidosis or plasma cell dyscrasias.
Ronald O. Perelman Department of Dermatology, NYU School of Medicine, USA. srivam01@med.nyu.edu
Monika
M
Srivastava
D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012535:Scalp / Q000473:pathology; D012859:Sjogren's Syndrome; D012875:Skin Diseases, Metabolic / Q000175:diagnosis* / Q000473:pathology