A role for D2 but not D1 dopamine receptors in the cross-sensitization between amphetamine and salt appetite.
A history of sodium depletions has been found to potentiate the psychomotor as well as the rewarding effects of amphetamine, an indirect dopamine agonist. The present experiments were conducted to further define the role of dopamine receptor subtypes in this cross-sensitization effect. Rats with a history of sodium depletions were found to display psychomotor sensitization to a D2 but not a D1 direct agonist. Cross-sensitization between salt appetite and amphetamine was found to be blocked by a D2 but not a D1 antagonist. Together, these results implicate D2 but not D1 receptor function in the cross-sensitization seen after sodium depletions.
University of Washington, Seattle, WA 98195, USA. jjc1@u.washington.edu
Jeremy J
JJ
Clark
Ilene L
IL
Bernstein
D000662:Amphetamines / Q000008:administration & dosage*; D000704:Analysis of Variance; D000818:Animals; D008297:Male; D009042:Motivation; D051381:Rats; D020318:Rats, Long-Evans; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
D000662:Amphetamines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017673:Sodium Chloride, Dietary