Acetylcholinesterase inhibitors from plants and fungi.
This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.
Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, UK.
Peter J
PJ
Houghton
Yuhao
Y
Ren
Melanie-Jayne
MJ
Howes
D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D001688:Biological Products; D002800:Cholinesterase Inhibitors