[Antioxidative effects of isoflavon genisteine-8-C-glycoside in vitro and in vivo].
Bioflavonoids (polyhydroxyphenols) are ubiquitous components of plants, fruits and vegetables; these compounds are efficient scavengers of free oxygen radicals and peroxides. The aim of this study was to investigate the antioxidative effects of genistein-8-C-glycoside (G8CG) isolated from the flowers of Lipinus luteus L. G8CG dose-dependently inhibited membrane lipid peroxidation and prevented GSH oxidation in human red blood cells and rat liver homogenates under tert-butylhydroperoxide-induced oxidative stress and single whole-body gamma-irradiation (1 Gy) of rats.
Zavodnik
L B
LB
Shkodich
A P
AP
Wielanek
M
M
Egorov
A I
AI
Zavodnik
I B
IB
Popov
Iu V
IuV
Ovchinnikov
V A
VA
Laman
N A
NA
Buko
V U
VU
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005720:Gamma Rays; D019833:Genistein / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D031297:Lupinus / Q000737:chemistry; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D014916:Whole-Body Irradiation
D000975:Antioxidants; D005960:Glucosides; C415443:genistein-8-c-glucoside; D019833:Genistein