Disseminated transmissible venereal tumor in a dog.
Transmissible venereal tumor (TVT) is a well-documented transplantable tumor in dogs, with no breed or sex predilection and a low metastatic rate. In this report, a 2-year-old intact female Mastiff that had numerous, rapidly growing masses throughout the subcutis mainly at the dorsal body plane, the caudal half of the ventral abdomen, and around the vulva was euthanized due to poor prognosis. Neoplastic nodules similar to those seen in the subcutis were also noted in the lung, anterior mediastinum, liver, spleen, kidney, and superficial and deep lymph nodes in both abdominal and thoracic cavities. The neoplastic nodules from the subcutis as well as metastatic foci revealed similar cytologic and histologic features, which were consistent with canine TVT. By immunohistochemical staining, the neoplastic cells were positive for lysozyme and vimentin but were negative for cytokeratin, desmin, CD3, and CD79a. The diagnosis of the TVT was further supported by the identification and analysis of long interspersed nuclear elements (LINE) from paraffin-embedded tumor tissue. This case is a rare example of TVT with multiorgan metastasis. In this case, the polymerase chain reaction technique was useful in differential diagnosis of canine round cell tumors because this technique can be applied in retrospective as well as future study.
Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Korea.
Mi-Sun
MS
Park
Yongbaek
Y
Kim
Min-Soo
MS
Kang
Sang-Yeon
SY
Oh
Doo-Youn
DY
Cho
Nam-Shik
NS
Shin
Dae-Yong
DY
Kim
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D009113:Muramidase / Q000032:analysis; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011379:Prognosis; D014685:Venereal Tumors, Veterinary / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D014746:Vimentin; D009113:Muramidase