Theory of spatial patterns of intracellular organelles.
Here we report on a generalized theory of spatial patterns of intracellular organelles, which are controlled by cells using cytoskeleton-based movements powered by molecular motors. The theory reveals that organelles exhibit one of the four distinct, stable patterns, namely aggregation, hyperdispersion, radial dispersion, and areal dispersion. Existence of specific patterns is determined by the contributions from three transport mechanisms, characterized by two Peclet numbers. The predicted patterns compare well with experimental data. This study provides a firm theoretical ground for classification of spatial patterns of organelles and understanding their regulation by cells.
Anh-Tuan
AT
Dinh
Chinmay
C
Pangarkar
Theo
T
Theofanous
Samir
S
Mitragotri
D000818:Animals; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D015388:Organelles / Q000502:physiology* / Q000648:ultrastructure*
D020409:Molecular Motor Proteins