Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone.
In order to evaluate the efficacy, the safety and the variation in plasma concentrations of estrogens, progesterone, PGFM, oxytocin, cortisol and prolactin after mid-pregnancy termination induced by aglepristone, 61 pregnant queens (33.3 + 4.2 days), were injected subcutaneously with 15 [corrected] mg/kg aglepristone, (Alizine) [corrected] repeated once 24 h later. Five queens served as control and received a placebo. The efficacy of aglepristone was 88.5% and termination of pregnancy was achieved in 50% of the queens within 3 days. Brief periods of depression and anorexia were noted in 9.3% of the queens before fetal expulsion (these symptoms were attributed to the phenomenon of fetal expulsions). Not one of the queens that aborted developed uterine disease. There were no changes in plasma concentrations of estrogen, prostaglandin, prolactin or oxytocin following aglepristone administration. However, there were significant increases in plasma concentrations of progesterone and cortisol 60 and 30 h, respectively, after aglepristone administration. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterised by an increase in estrogen, PGFM and oxytocin concentrations, whereas prolactin and cortisol levels remained at a basal level.
Fieni
Francis
F
Laboratory of Biotechnology and Pathology of Reproduction, National Veterinary School, BP 40706, 44307 Nantes, Cedex 03, France. fieni@vet-nantes.fr
Martal
Jacques
J
Marnet
Pierre Guy
PG
Siliart
Brigitte
B
Guittot
Franck
F
D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000028:Abortion, Induced / Q000379:methods / Q000662:veterinary*; D000034:Abortion, Veterinary / Q000097:blood / Q000139:chemically induced*; D000818:Animals; D002415:Cats / Q000097:blood / Q000502:physiology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D004963:Estrenes / Q000494:pharmacology*; D004967:Estrogens / Q000097:blood; D005260:Female; D008297:Male; D010121:Oxytocin / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D004967:Estrogens; C419063:aglepristone; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D010121:Oxytocin; D015237:Dinoprost