Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate.
Polymethylmethacrylate (PMMA) bone cement is widely used for prosthetic fixation in orthopaedic surgery; however, the interface between bone and cement is a weak zone. We developed a bioactive PMMA cement through modification with gamma-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. The purpose of this study was to compare the handling, mechanical and histological properties of the modified bone cement with those of the conventional cement. The modified specimens exhibited higher bonding strength between bone and implant. Histological observation and micro-focus X-ray computed tomogram (micro-CT) images showed that the modified cement exhibited osteoconduction, which the conventional PMMA bone cement lacked. The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation.
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan. mdddd940@ybb.ne.jp
Tadashi
T
Tsukeoka
Masahiko
M
Suzuki
Chikara
C
Ohtsuki
Atsushi
A
Sugino
Yoshikazu
Y
Tsuneizumi
Jin
J
Miyagi
Kouichi
K
Kuramoto
Hideshige
H
Moriya
D000085:Acetates / Q000032:analysis / Q000737:chemistry*; D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D001843:Bone Cements / Q000032:analysis / Q000737:chemistry*; D018786:Bone Substitutes / Q000032:analysis / Q000737:chemistry; D017610:Calcium Compounds; D019245:Compressive Strength; D004285:Dogs; D005260:Female; D005269:Femur / Q000737:chemistry / Q000166:cytology* / Q000502:physiology / Q000601:surgery; D006244:Hardness; D008422:Materials Testing; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry*; D016348:Osseointegration / Q000502:physiology; D019904:Polymethyl Methacrylate / Q000032:analysis / Q000737:chemistry*; D012821:Silanes / Q000032:analysis / Q000737:chemistry*; D013499:Surface Properties
D000085:Acetates; D001843:Bone Cements; D018786:Bone Substitutes; D017610:Calcium Compounds; D008689:Methacrylates; D012821:Silanes; C017492:methacryloxypropyltrimethoxysilane; D019904:Polymethyl Methacrylate; C120662:calcium acetate