Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes.
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits beta-hydride elimination.
Michael
Forrest E
FE
University of Washington, Seattle, 98195-1700, USA. fmichael@chem.washington.edu
Cochran
Brian M
BM