Lipoprotein (a) in young individuals as a marker of the presence of ischemic heart disease and the severity of coronary lesions.
The purpose of this study was to evaluate whether high levels and small isoforms of lipoprotein (a) [Lp(a)] are markers of risk of early myocardial infarction and markers of the severity of coronary atherosclerosis. Lp(a) levels and small apo(a) isoforms were higher in 222 patients than in 199 controls (p<0.001). In patients, Lp(a)> or =30 mg/dL was associated with the presence of coronary lesions (p=0.007) and the severity of coronary atherosclerosis (p=0.002). The present study suggests that Lp(a) levels and small isoforms are markers of early myocardial infarction and that Lp(a) levels > or =30 mg/dL are associated with severe patterns of coronary atherosclerosis.
Department of Cardiology, Research Centre, Hospital Universitario La Fe, Valencia, Spain.
Esther
E
Zorio
Cristina
C
Falco
Miguel A
MA
Arnau
Francisco
F
España
Ana
A
Osa
Luis A
LA
Ramon
Remedios
R
Castello
Luis
L
Almenar
Miguel A
MA
Palencia
Amparo
A
Estelles
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000473:pathology*; D020033:Protein Isoforms; D012720:Severity of Illness Index
D015415:Biomarkers; D017270:Lipoprotein(a); D020033:Protein Isoforms