Familial aggregation of sinonasal polyps correlates with severity of disease.
OBJECTIVE
Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP.


METHODS
A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance).


RESULTS
Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs.


CONCLUSIONS
Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity.


METHODS
B-2b.
Cohen
Noam A
NA
Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA. cohenn@uphs.upenn.edu
Widelitz
Jeffrey S
JS
Chiu
Alexander G
AG
Palmer
James N
JN
Kennedy
David W
DW
D015982:Bias; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D009298:Nasal Polyps / Q000453:epidemiology* / Q000235:genetics; D010254:Paranasal Sinus Diseases / Q000453:epidemiology* / Q000235:genetics; D011127:Polyps / Q000453:epidemiology / Q000235:genetics; D012720:Severity of Illness Index; D017678:Sex Distribution; D011795:Surveys and Questionnaires