Cyclin e overexpression reduces infiltrative growth in breast cancer: yet another link between proliferation control and tumor invasion.
Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.
Berglund
Pontus
P
Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
Landberg
Göran
G
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019927:Cyclin E / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*
D018797:Cell Cycle Proteins; D019927:Cyclin E