Fatal isoflurane hepatotoxicity without re-exposure.
Isoflurane is less hepatotoxic than its predecessors, halothane and enflurane. We present a 68-year-old man who developed fulminant and fatal hepatic necrosis two days after open cholecystectomy done under isoflurane anesthesia. Laboratory findings included grossly elevated transaminases and bilirubin and prolonged prothrombin time. Serological studies were negative for viral hepatitis. Postmortem examination demonstrated centrilobular necrosis of liver.
Ihtiyar
Enver
E
Department of General Surgery, Osmangazi University Faculty of Medicine, 26480 Eskisehir, Turkey.
Algin
Cem
C
Haciolu
Alper
A
Isiksoy
Serap
S
D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002763:Cholecystectomy; D002764:Cholecystitis / Q000601:surgery*; D017809:Fatal Outcome; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D009336:Necrosis
D018685:Anesthetics, Inhalation; D007530:Isoflurane