A model of protein conformational substates.
Many proteins have been observed to exist in a large number of conformations that are believed to play an important role in their dynamics. A model of protein conformational substates that incorporates the ideas of frustration and disorder in analogy to glasses and spin glasses is proposed. Applications to x-ray diffraction, Mössbauer studies, and recombination experiments are discussed.
Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544.
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Stein