An introduction to thiol redox proteins in the endoplasmic reticulum and a review of current electrochemical methods of detection of thiols.
This aim of this paper is to expound the complexity of thiol redox systems in the endoplasmic reticulum of eukaryotic cells to the electroanalytical community. A summary of the state of the art in electrochemical methods for detection of thiols gives an insight into the challenges that need to be addressed to bridge the disparity between current analytical techniques and applications in a 'real' biological scenario.
Chemistry Department and Centre for Bioactive Chemistry, University of Durham, South Road, Durham, UKDH1 4HT.
Jaanus
J
Kruusma
Adam M
AM
Benham
J A Gareth
JA
Williams
Ritu
R
Kataky
D000818:Animals; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D010944:Plants; D013438:Sulfhydryl Compounds / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*
D013438:Sulfhydryl Compounds