Immunotherapy with virus-specific cytotoxic T lymphocytes after organ transplantation.
Adoptive immunotherapy with antigen specific cytotoxic T lymphocytes can favorably impact the outcome of serious herpesvirus infections in organ transplant recipients. Current challenges in this field include the determination of which patients are at highest risk, and the development of protocols that permit more rapid expansion of virus specific effector cells.
Penn State Children's Hospital, Hershey, PA 17033, USA. klucas@psu.edu
Kenneth G
KG
Lucas
Qi
Q
Sun
D002472:Cell Transformation, Viral; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016377:Organ Transplantation; D033581:Stem Cell Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000821:virology*; D014181:Transplantation Immunology