[Vagina cancer in a young woman exposed to diethylstilbestrol: case report and literature review].
We analyzed a 20 year-old patient case exposed in utero to diethylstilbestrol, as probably predisposed factor in vaginal cancer. The histopathological report of the incisional biopsy was clear cell vaginal adenocarcinoma, stage III, widespread to the pelvic wall, with metastasis to regional lymph nodes, and lack of distant metastasis. We decided surgical management: protocolized laparotomy, peritoneal washing, retroperitoneal node biopsies and a radical hysterectomy, Piver III, with two thirds parts of vagina. By poor prognosis we decided to offer an adjuvant management, with systemic chemotherapy.
Hospital General de Zona 57, La Quebrada, IMSS. novoaart@prodigy.net.mx
Arturo
A
Novoa Vargas
Conrado
C
Grados García
Roberto
R
Bustillos de Cima
Berenice
B
Malagón Millán
D018262:Adenocarcinoma, Clear Cell / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011379:Prognosis; D011860:Radiography, Abdominal; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
D004054:Diethylstilbestrol