Reply to "The role of soluble interleukin-6 receptor in inflammatory diseases" [Immunol Lett 2005;98(1):171].
We agree with the comments of Mr. Maggio and colleagues. The exact role of serum IL-6R and the relation between this and the IL-6/sIL-6R complex in inflammatory disorders has not been completely clarified. We suggest a discrepancy between sIL-6R concentrations and measurable IL-6/sIL-6R complex, not excluding the positive contribution of sIL-6R as a marker of neuro-immunoregulatory and inflammatory status in the central nervous system.
Maria
M
Michalopoulou
Chryssoula
C
Nikolaou
Stylianos
S
Chatzipanagiotou
Catherine
C
Cambouri
Antonios
A
Tavernarakis
Nectaria-Malamatina
NM
Alexandri
Michael
M
Rentzos
Dimitrios
D
Vassilopoulos
D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D019947:Receptors, Interleukin-6 / Q000097:blood*; D012995:Solubility
D015850:Interleukin-6; D019947:Receptors, Interleukin-6