Ultrasound promoted regioselective nitration of phenols using dilute nitric acid in the presence of phase transfer catalyst.
Phenols are selectively nitrated to o-nitrophenol along with rate enhancement using dilute nitric acid (6 wt%)/tetra butyl ammonium bromide (TBAB) under sonication. The selectivity can also be reversed to p-nitrophenol using NaBr as a catalyst. Kinetic analysis of nitration of phenol both with and without sonication has been investigated by variation of reaction parameters such as catalyst, nitric acid and substrate concentration.
Department of Chemistry, Institute of Chemical Technology, Mumbai University, N. Parekh Marg, Matunga, Mumbai 400 019, India.
Nitin S
NS
Nandurkar
Mayur J
MJ
Bhanushali
Sachin R
SR
Jagtap
Bhalchandra M
BM
Bhanage
D002384:Catalysis; D007700:Kinetics; D009566:Nitrates / Q000737:chemistry* / Q000528:radiation effects; D017942:Nitric Acid / Q000737:chemistry* / Q000528:radiation effects*; D044367:Phase Transition; D010636:Phenols / Q000737:chemistry* / Q000528:radiation effects; D013010:Sonication
D009566:Nitrates; D010636:Phenols; D017942:Nitric Acid