[Transfer factor as specific immunomodulator in the treatment of moderate-severe atopic dermatitis].
BACKGROUND
Atopic dermatitis is a skin inflammatory disease which has been associated to high levels of IgE, eosinophiles and change of T lymphocytes. The transfer factor is an immunomodulator active substance and decreases the number of inflammatory cells and the severity of the symptoms of atopic dermatitis.


OBJECTIVE
To determine the efficacy of the transfer factor as treatment of moderate and severe atopic dermatitis.


METHODS
Articles related to treatment with transfer factor in the atopic dermatitis were looked up in Medline and EMBASE, and the ones referring to controlled studies in patients with moderate and severe atopic dermatitis in accord to SCORAD.


RESULTS
We found seven articles with 121 patients and 88 controls demonstrating significant decrease in the symptoms of the SCORAD index, decreased IgE, and eosinophils in patients treated with transfer factor.


CONCLUSIONS
The transfer factor is a choice treatment for moderate and severe atopic dermatitis.
Flores Sandoval
G
G
Servicio de inmunología y alergia, Hospital Licenciado Adolfo López Mateos, ISSSTE, Florida, México, DF.
Gómez Vera
J
J
Orea Solano
M
M
López Tiro
J
J
Serrano
E
E
Rodríguez
Abraham
A
Rodríguez
Azucena
A
Estrada Parra
S
S
Jiménez Saab
N
N
D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D012720:Severity of Illness Index; D014165:Transfer Factor / Q000627:therapeutic use*
D014165:Transfer Factor