[Clinical analysis of histocytic necrotizing lymphadenitis].
OBJECTIVE
To understand the clinical features and histopathology of histocytic necrotizing lymphadenitis (HNL) so as to better recognize the disease.


METHODS
The clinical features, histopathology, and diagnosis of 10 patients admitted to our hospital were retrospectively analyzed.


RESULTS
The clinical features of these 10 cases included: young females were the majority; lymphadenopathy and fever were the most common clinical manifestations; some cases were accompanied by connective tissue diseases. Histopathologic examination showed distinctive necrosis and around the necrotic foci, variable proliferations of histocytes but generally without infiltration of neutrophils.


CONCLUSIONS
HNL has some typical histopathological alterations and relatively fine prognosis,but it tends to be misdiagnosed as lymphoma or lymphoid tuberculosis and may be accompanied by other diseases.
Pei
Min-fei
MF
Department of Hematology,Second Xiangya Hospital, Central South University, Changsha 410011, China. peiminfei@tom.com
Zhu
Xiao
X
Zhang
Guang-sen
GS
Xu
Yun-xiao
YX
Shen
Jian-kai
JK
Dai
Chong-wen
CW
Zheng
Wen-li
WL
Yang
Jun-jie
JJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003937:Diagnosis, Differential; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis