[Butyrylcholinesterase deficiency: how to analyse the cholinesterase activity in small children?].
We report the case of a prolonged neuromuscular blockade in an 18-month-old age girl following administration of a usual dose of succinylcholine. The diagnosis was highly suggested by the clinical history while cholinesterase activity was included in adult normal values but below values of a personal series of 41 small children. The familial analysis of dibucaine and fluoride number confirmed the hypothesis of an atypical variant (AA phenotype). The cholinesterase activity is higher in small children than in adult and has to be analysed according to the age.
Service d'Anesthésie et de Réanimation Chirurgicale, Hôtel-Dieu-Hôpital Mère-Enfant, CHU de Nantes, 44093 Nantes Cedex 01, France. corinne.lejus@chu-nantes.fr
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Lejus
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Delaroche
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Trille
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Blanloeil
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Pinaud
D000367:Age Factors; D000779:Anesthetics, Local; D002091:Butyrylcholinesterase / Q000172:deficiency* / Q000235:genetics; D002802:Cholinesterases / Q000097:blood*; D003992:Dibucaine; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007223:Infant; D019148:Neuromuscular Blockade; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects; D010641:Phenotype; D013390:Succinylcholine / Q000009:adverse effects
D000779:Anesthetics, Local; D009467:Neuromuscular Depolarizing Agents; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D013390:Succinylcholine; D003992:Dibucaine