Stem cells and cancer: two faces of eve.
Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better modes of treatment.
Clarke
Michael F
MF
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. mfclarke@stanford.edu
Fuller
Margaret
M
D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D013234:Stem Cells