Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States.
By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC<or=2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Pletz.Mathias@mh-hannover.de
Mathias W R
MW
Pletz
Ardaman P
AP
Shergill
Lesley
L
McGee
Bernard
B
Beall
Cynthia G
CG
Whitney
Keith P
KP
Klugman
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D064704:Levofloxacin; D008134:Long-Term Care; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D015242:Ofloxacin / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin