[The preotective effects of total glycosides Rubus parviflolius on cerebral ischemic in rat].
OBJECTIVE
To observe the protective effects of total glycosides Rubus parviflolius (TGRP) on local cerebral ischemic.


METHODS
The local cerebral ischemia in rat was made by middle cerebral artery occlusion(MACO). The infraction weight was determined by TTC stain. SOD, MDA, GSH and apoptotis were determined with different method respectively.


RESULTS
TGRP 20, 10 mg x kg(-1) ig markedly improved the abnormal nervous symptoms, incredsed the SOD, GSH activity and reduced contentes of MDA in brain of MACO rat, TGRP 20 mg x kg(-1) ig significantly decreased the numbers of apoptotic cells in ischemic cortex.


CONCLUSIONS
TGRP has protective effects against cerebral infraction, and its mechanism may be related to anti-apoptotis and free radical.
Department of Pharmacy, Chongqing University of Medical Science, Chongqing 400016, China.
Ji-Sheng
JS
Wang
Zong-Yin
ZY
Qiu
Yong-Peng
YP
Xia
Hui-Zhi
HZ
Li
Ling-Yan
LY
Ren
Li
L
Zhang
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry
D006027:Glycosides; D018696:Neuroprotective Agents