The evolution of azelaic acid.
Azelaic acid (AzA) is a naturally occurring dicarboxylic acid that has a long and complex history in the treatment of skin disorders. We summarize research on AzA from the past 25 years and follow its progress from a treatment of hyperpigmentation to a therapy for acne vulgaris and inflammatory (papulopustular) rosacea.
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Alan B
AB
Fleischer
D000152:Acne Vulgaris / Q000188:drug therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000627:therapeutic use*; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy; D012393:Rosacea / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*
D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; C010038:azelaic acid