Profile of serum S100beta levels during maturation in fetal and neonatal sheep.
Serum levels of the protein S-100beta are dependent on three factors: rate of production, permeability of the blood-brain barrier, and rate of clearance. In the developing fetus and neonate all of these factors change at different rates. This study was performed to determine how serum S-100 levels varied during fetal and early postnatal life. Blood samples were obtained from 41 fetal and neonatal lambs. The blood was separated in a centrifuge and the serum drawn off and assayed for S-100beta using a commercially available radioimunoassay kit. S-100beta did not appear in the blood until halfway through pregnancy. Thereafter, levels steadily increased until 1 month after birth. Following this, S-100beta levels decreased progressively until by 1 year of age, they had reached a plateau. S-100beta levels change significantly with normal fetal and neonatal maturation. Valid interpretation of other data from subjects of similar developmental stage must take into consideration this physiological variation.
Parry
Andrew J
AJ
Department of Pediatric Cardiac Surgery, University of California-San Francisco, San Francisco, CA, USA.
McMullan
D Michael
DM
Yelich
Susan
S
Hanley
Frank L
FL
D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000502:physiology*; D001812:Blood-Brain Barrier / Q000196:embryology / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000502:physiology*; D011247:Pregnancy; D009418:S100 Proteins / Q000097:blood*; D012756:Sheep
D009418:S100 Proteins