Characteristics of scratching behavior induced by some chemical mediators in hairless mice.
To find the characteristics of scratching behavior in hairless mice (HR-1), compound 48/80 and some putative chemical mediators of allergic reaction were injected intradermally into the backs of mice, and the number of scratching behaviors was measured. As reference mice, NC/Nga, ICR, and ddY mice were used. Scratching behavior in HR-1 and ICR mice was increased dose-dependently by compound 48/80. The same result was also observed with NC/Nga and ddY mice. However, the response in NC/Nga and ddY mice was far less than those of HR-1 and ICR mice. Similar to NC/Nga and ddY mice, HR-1 mice showed less sensitivity to histamine than ICR mice. On the other hand, the HR-1 mice showed a high response to serotonin compared with those of the NC/Nga and ddY mice. The scratching behavior in HR-1 mice induced by substance P was increased, but the effect was less potent than those in NC/Nga, ICR, and ddY mice. These results suggest that the scratching behavior induced by compound 48/80 in HR-1 mice is mainly attributable to serotonin.
Takubo
Miho
M
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Ueda
Yuhki
Y
Yatsuzuka
Rie
R
Jiang
Shuishi
S
Fujii
Yoko
Y
Kamei
Chiaki
C
D000818:Animals; D000982:Antipruritics / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000517:prevention & control; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000633:toxicity; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D008812:Mice, Hairless; D008813:Mice, Inbred ICR; D011537:Pruritus / Q000139:chemically induced* / Q000517:prevention & control; D012701:Serotonin / Q000633:toxicity; D012702:Serotonin Antagonists / Q000494:pharmacology; D013045:Species Specificity; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors / Q000633:toxicity*
D000982:Antipruritics; D012702:Serotonin Antagonists; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D008784:Methysergide