Thyroid nodules in the population living around Semipalatinsk nuclear test site: possible implications for dose-response relationships study.
The risk of radiation-induced nodules is higher than the risk for radiation-induced cancer. Risk factors and specific modifiers of the dose-response relationship may vary among different populations and not be well recognized. Many thyroid studies have considered thyroid nodularity itself, but not specific morphological types of thyroid nodules. There are many specific types of thyroid nodules which follow a morphological classification of thyroid lesions, including some congenital and tumor-like conditions. Modern equipment and technique can help us to identify particular specific types of thyroid nodules. In this study we report some results of a clinically applicable approach to materials derived from three studies. From 1999 through 2002, we have screened 571 current residents from 4 exposed and 1 control village near the Semipalatinsk Nuclear Test Site area, who were of similar ages (<20) at the time of major radiation fallout events at the SNTS. Prevalent nodules were identified by ultrasound and fine-needle aspiration biopsy, cytopathology results. Analysis of ultrasound images and cytopathology of thyroid lesions among exposed and non-exposed population allowed us to distinguish some interesting ultrasound features for specific types of thyroid nodules. We believe that it would be interesting and possibly more informative for thyroid dosimetry studies to consider specific morphological types of thyroid nodules. We need more detailed research to clarify the feasibility of applying these findings for study of the dose-response relationship.
Semipalatinsk State Medical Academy, Kazakhstan. zhuma@relcom.kz
Zhaxybay
Z
Zhumadilov
D000328:Adult; D001706:Biopsy / Q000706:statistics & numerical data; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007623:Kazakhstan / Q000453:epidemiology; D008297:Male; D009689:Nuclear Warfare / Q000706:statistics & numerical data*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D016606:Thyroid Nodule / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D014463:Ultrasonography / Q000706:statistics & numerical data