Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA mice.
In the present study, the total antioxidant status was used as a biomarker to evaluate oxidative stress induced by proton, HZE-particle and gamma radiation in CBA mice. The results demonstrated that the plasma level of TAS was significantly decreased (P < 0.05) in CBA mice after exposure to a 50-cGy dose of radiation from HZE particles or a 3-Gy dose of radiation from protons or gamma rays. Diet supplementation with Bowman-Birk Inhibitor Concentrate (BBIC), L-selenomethionine (L-SeM), or a combination of N-acetyl cysteine, sodium ascorbate, co-enzyme Q10 (CoQ10), alpha-lipoic acid, L-SeM and vitamin E succinate could partially or completely prevent the reduction in the plasma level of TAS in CBA mice exposed to proton or HZE-particle radiation. The selected antioxidant combination with or without CoQ10 has a comparable protective effect on the gamma-radiation-induced drop in TAS in CBA mice. These results indicate that BBIC, L-SeM and the selected antioxidant combinations may serve as countermeasures for space radiation-induced adverse biological effects.
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Jun
J
Guan
Jelena
J
Stewart
Jeffrey H
JH
Ware
Zhaozong
Z
Zhou
Jeremiah J
JJ
Donahue
Ann R
AR
Kennedy
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003359:Cosmic Radiation; D019587:Dietary Supplements; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D013026:Space Flight
D000975:Antioxidants; D011837:Radiation-Protective Agents