Preliminary study of the relationship between DAZ gene copy deletions and spermatogenic impairment in Chinese men.
Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men. The deletion patterns correlate with spermatogenic impairment in a Chinese population.
Yang
Yuan
Y
Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Xiao
Cuiying
C
Zhang
Sizhong
S
Zhoucun
A
A
Li
Xiang
X
Zhang
Sixiao
S
D000328:Adult; D044466:Asian People / Q000235:genetics*; D000075364:Deleted in Azoospermia 1 Protein; D017353:Gene Deletion; D018628:Gene Dosage; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D016601:RNA-Binding Proteins / Q000235:genetics*; D013091:Spermatogenesis / Q000235:genetics*
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins