Benzotetramisole: a remarkably enantioselective acyl transfer catalyst.
[reaction: see text] A commercially available pharmaceutical, tetramisole, was found to be a competent enantioselective acylation catalyst. Its benzannellated analogue, benzotetramisole (BTM), produced outstanding enantioselectivities in kinetic resolution of secondary benzylic alcohols.
Birman
Vladimir B
VB
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, USA. birman@wustl.edu
Li
Ximin
X
D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013773:Tetramisole / Q000031:analogs & derivatives* / Q000737:chemistry*
D001592:Benzyl Alcohols; C515434:benzotetramisole; D013773:Tetramisole