Plasmodium post-genomics: better the bug you know?
Since the publication of the sequence of the genome of Plasmodium falciparum, the major causative agent of human malaria, many post-genomic studies have been completed. Invaluably, these data can now be analysed comparatively owing to the availability of a significant amount of genome-sequence data from several closely related model species of Plasmodium and accompanying global proteome and transcriptome studies. This review summarizes our current knowledge and how this has already been--and will continue to be--exploited in the search for vaccines and drugs against this most significant infectious disease of the tropics.
Kooij
Taco W A
TW
Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Janse
Chris J
CJ
Waters
Andrew P
AP
D000818:Animals; D015870:Gene Expression; D018503:Genome, Protozoan; D010961:Plasmodium / Q000187:drug effects / Q000235:genetics* / Q000276:immunology / Q000502:physiology*; D020543:Proteome
D020543:Proteome