High frequency oscillatory ventilation and prone positioning in a porcine model of lavage-induced acute lung injury.
BACKGROUND
This animal study was conducted to assess the combined effects of high frequency oscillatory ventilation (HFOV) and prone positioning on pulmonary gas exchange and hemodynamics.


METHODS
Saline lung lavage was performed in 14 healthy pigs (54 +/- 3.1 kg, mean +/- SD) until the arterial oxygen partial pressure (PaO2) decreased to 55 +/- 7 mmHg. The animals were ventilated in the pressure controlled mode (PCV) with a positive endexpiratory pressure (PEEP) of 5 cmH2O and a tidal volume (VT) of 6 ml/kg body weight. After a stabilisation period of 60 minutes, the animals were randomly assigned to 2 groups. Group 1: HFOV in supine position; group 2: HFOV in prone position. After evaluation of prone positioning in group 2, the mean airway pressure (Pmean) was increased by 3 cmH2O from 16 to 34 cmH2O every 20 minutes in both groups accompanied by measurements of respiratory and hemodynamic variables. Finally all animals were ventilated supine with PCV, PEEP = 5 cm H2O, VT = 6 ml/kg.


RESULTS
Combination of HFOV with prone positioning improves oxygenation and results in normalisation of cardiac output and considerable reduction of pulmonary shunt fraction at a significant (p < 0.05) lower Pmean than HFOV and supine positioning.


CONCLUSIONS
If ventilator induced lung injury is ameliorated by a lower Pmean, a combined treatment approach using HFOV and prone positioning might result in further lung protection.
Brederlau
Joerg
J
Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Würzburg, Oberdürrbacher Str, 6, 97080 Würzburg, Germany. brederlau_j@klinik.uni-wuerzburg.de
Muellenbach
Ralf
R
Kredel
Markus
M
Greim
Clemens
C
Roewer
Norbert
N