[Mechanism of cancer-induced bone pain].
Bone pain is one of the major complications of bone metastases and profoundly deteriorates quality of life in cancer patients. It has been suggested that the nerve injuries by tumor invasion and the inflammatory factors secreted by cancer cells are involved in the pathophysiology of bone pain. Recent studies including ours suggest that the activation of acid-sensing receptors by tumor-induced acidosis in bone metastases also plays a part in causing bone pain. In this review, the current understanding of the mechanisms of cancer-induced bone pain is discussed.
Osaka University Graduate School of Dentistry, Department of Biochemistry.
Hiroki
H
Wakabayashi
Toru
T
Hiraga
Toshiyuki
T
Yoneda
D062565:Acid Sensing Ion Channels; D000138:Acidosis; D051700:Activating Transcription Factor 3 / Q000502:physiology; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications* / Q000556:secondary*; D001842:Bone and Bones / Q000294:innervation; D016207:Cytokines / Q000502:physiology; D006801:Humans; D010146:Pain / Q000209:etiology*; D011788:Quality of Life; D015222:Sodium Channels / Q000502:physiology; D050916:TRPV Cation Channels / Q000502:physiology
C508378:ASIC3 protein, mouse; D062565:Acid Sensing Ion Channels; D051700:Activating Transcription Factor 3; D016207:Cytokines; D015222:Sodium Channels; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human