Management of unanticipated outcomes in transgenic mouse facilities.
Experimental manipulations of rodents may result in unexpected adverse phenotypes that present problems from both regulatory and animal care-veterinary perspectives. The authors discuss the implications of unanticipated outcomes and describe a cage card-based tracking system used at the Harvard Medical School for the early detection and handling of unanticipated phenotypes in genetically altered rodents.
Pritt
Stacy
S
Covance Research Products, Inc., Denver, PA 17517, USA. stacy.pritt@covance.com
Cozine
Kerri
K
Warren
Henry
H
D035661:Animal Care Committees / Q000331:legislation & jurisprudence; D000822:Animal Husbandry / Q000379:methods*; D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D003625:Data Collection / Q000379:methods; D004195:Disease Models, Animal; D006799:Housing, Animal; D007756:Laboratory Animal Science / Q000331:legislation & jurisprudence / Q000379:methods*; D051379:Mice; D008822:Mice, Transgenic; D014730:Veterinary Medicine / Q000379:methods* / Q000592:standards