Teaching molecular genetics: Chapter 3--Proteomics in nephrology.
The novel discipline of proteomics has experienced a rapid growth in the recent past and has great potentials for the future. The study of proteins on a genomic scale enables a large number of proteins to be analysed simultaneously. Moreover, proteomic analysis reveals the presence of protein isoforms and post-translational modifications, both of which have the potential to regulate protein complex formation, activity and function. As such, the assessment of the proteome, unlike genomic analysis, provides a view of biological processes at their level of occurrence. The knowledge thus gained is important not only for a better understanding of renal physiology and pathophysiology, but also for the identification of disease markers and the development of new therapies. This review applies the science of proteomics to nephrology: our aim is to give an overview of the discipline, providing background information and outlining the scope, advantages and limitations of proteomics.
Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. P.Groenen@pathol.umcn.nl
Patricia J T A
PJ
Groenen
Lambert P W J
LP
van den Heuvel
D015415:Biomarkers / Q000032:analysis* / Q000652:urine; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D013058:Mass Spectrometry / Q000379:methods*; D008967:Molecular Biology; D009398:Nephrology; D040081:Protein Array Analysis; D020543:Proteome / Q000032:analysis; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014556:Urine / Q000737:chemistry
D015415:Biomarkers; D020543:Proteome