One-pot borylation/amination reactions: syntheses of arylamine boronate esters from halogenated arenes.
[reaction: see text] A one-pot protocol for converting 1,3- and 1,4-substituted aryl halides to arylamine boronate esters is described. This is achieved by sequential Ir-catalyzed aromatic borylation at the least hindered C-H bond of the aryl halide and subsequent Pd-catalyzed C-N coupling at the halide position of the crude arylboronic ester.
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Daniel
D
Holmes
Ghayoor A
GA
Chotana
Robert E
RE
Maleczka
Milton R
MR
Smith
D000586:Amination; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
D001896:Boron Compounds; D004952:Esters; D006846:Hydrocarbons, Halogenated