Congenital indifference to pain and deletion of chromosome 10q-: new association.
We describe a case of a de novo terminal deletion of the long arm of chromosome 10 with the novel feature of congenital indifference to pain in a 2-year 10-month-old boy. Relative indifference to pain defined by a lack of emotional response to pain has not been described previously in association with the terminal deletion of the long arm of chromosome 10.
Joshi
Charuta
C
Department of Pediatrics, University of Manitoba, Winnipeg, Canada. cjoshi@hsc.mb.ca
Dawson
Angelika J
AJ
Sanders
Shannon R
SR
Prasad
Chitra
C
D002675:Child, Preschool; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002658:Developmental Disabilities / Q000175:diagnosis / Q000235:genetics; D004431:Ear, External / Q000002:abnormalities; D004644:Emotions; D004948:Esotropia / Q000175:diagnosis / Q000235:genetics; D005500:Follow-Up Studies; D006801:Humans; D006987:Hypesthesia / Q000175:diagnosis / Q000235:genetics*; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009123:Muscle Hypotonia / Q000175:diagnosis / Q000235:genetics