Stress, cortisol, and periodontitis in a population aged 50 years and over.
Periodontitis and its relationship with psycho-neuro-immunological variables, such as psychological stress and cortisol, have been little explored. The objective of this study was to evaluate the extent and severity of chronic periodontitis and its association with the levels of salivary cortisol and the scores obtained with a stress questionnaire in a population aged 50 years and over. We studied 235 individuals in a cross-sectional study. They answered the Lipp's Inventory of Stress Symptoms for Adults, were instructed to collect three saliva samples for cortisol analysis, and were examined for evaluation for periodontitis. Based on logistic regression, cortisol levels were positively associated with the following outcomes: means of clinical attachment level (CAL) > = 4 mm [OR = 5.1, 95%CI (1.2, 20.7)]; 30% of sites with CAL > = 5 mm [OR = 6.9, 95%CI (1.7, 27.1)]; and 26% of sites with probing depth > = 4 mm [OR = 10.7, 95%CI (1.9, 54.1)] after adjustment for confounding variables. The results suggest that cortisol levels were positively associated with the extent and severity of periodontitis.
Post-graduate Program in Epidemiology, Faculty of Medicine, Federal University of Rio Grande do Sul, 2600/414 Porto Alegre, RS 90035-003, Brazil. juhilger@terra.com.br
J B
JB
Hilgert
F N
FN
Hugo
D R
DR
Bandeira
M C
MC
Bozzetti
D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001938:Brazil / Q000453:epidemiology; D017028:Caregivers / Q000523:psychology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003704:Dementia / Q000451:nursing; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D017622:Periodontal Attachment Loss / Q000453:epidemiology; D010518:Periodontitis / Q000453:epidemiology* / Q000378:metabolism / Q000523:psychology; D010555:Personality Inventory; D010913:Pituitary-Adrenal System / Q000378:metabolism; D015203:Reproducibility of Results; D012463:Saliva / Q000378:metabolism; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000453:epidemiology* / Q000378:metabolism
D006854:Hydrocortisone