Primary laryngeal lymphoma: case report.
Extranodal laryngeal lymphoma is extremely rare. We report a case of primary laryngeal lymphoma in a 76-year-old man who had presented with a 7-week history of progressive hoarseness. Laryngoscopy revealed asymmetry of the right false vocal fold. Pathology of a deep biopsy specimen identified a malignant, diffuse, CD20-positive, B-cell lymphoma. The stage IE lymphoma completely resolved after treatment with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) and rituximab. Despite its relative rarity, the consequences of a missed diagnosis warrant vigilance for this type of laryngeal tumor.
Department of Otolaryngology-Head and Neck Surgery, Marshfield Clinic, Marshfield, WI 54449, USA.
Ronnie
R
Word
Andrew C
AC
Urquhart
Victor S
VS
Ejercito
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006685:Hoarseness; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D007828:Laryngoscopy; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use; D014827:Vocal Cords / Q000473:pathology
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone