Generation of cloned transgenic pigs rich in omega-3 fatty acids.
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
Liangxue
L
Lai
Jing X
JX
Kang
Rongfeng
R
Li
Jingdong
J
Wang
William T
WT
Witt
Hwan Yul
HY
Yong
Yanhong
Y
Hao
David M
DM
Wax
Clifton N
CN
Murphy
August
A
Rieke
Melissa
M
Samuel
Michael L
ML
Linville
Scott W
SW
Korte
Rhobert W
RW
Evans
Thomas E
TE
Starzl
Randall S
RS
Prather
Yifan
Y
Dai
D000818:Animals; D030801:Animals, Genetically Modified / Q000378:metabolism*; D017173:Caenorhabditis elegans; D019976:Cloning, Organism / Q000379:methods*; D015525:Fatty Acids, Omega-3 / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008460:Meat / Q000032:analysis; D018482:Muscle, Skeletal / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D013552:Swine / Q000502:physiology*; D014018:Tissue Distribution
D015525:Fatty Acids, Omega-3