Scattered dose to thyroid from prophylactic cranial irradiation during childhood: a Monte Carlo study.
The purpose of this study was to estimate the scattered dose to thyroid from prophylactic cranial irradiation during childhood. The MCNP transport code and mathematical phantoms representing the average individual at ages 3, 5, 10, 15 and 18 years old were employed to simulate cranial radiotherapy using two lateral opposed fields. The mean radiation dose received by the thyroid gland was calculated. A 10 cm thick lead block placed on the patient's couch to shield the thyroid was simulated by MCNP code. The Monte Carlo model was validated by measuring the scattered dose to the unshielded and shielded thyroid using three different humanoid phantoms and thermoluminescense dosimetry. For a cranial dose of 18 Gy, the thyroid dose obtained by Monte Carlo calculations varied from 47 to 79 cGy depending upon the age of the child. Appropriate placement of the couch block resulted in a thyroid dose reduction by 39 to 54%. Thyroid dose values at all possible positions of the radiosensitive gland with respect to the inferior field edge at five different patient ages were found. The mean difference between Monte Carlo results and thyroid dose measurements was 9.6%.
Department of Medical Physics, University Hospital of Iraklion, 71110 Iraklion, Crete, Greece. mazonak@med.uoc.gr
Michalis
M
Mazonakis
Antonis
A
Tzedakis
John
J
Damilakis
Haris
H
Varveris
Stefanos
S
Kachris
Nicholas
N
Gourtsoyiannis
D001822:Body Burden; D001932:Brain Neoplasms / Q000517:prevention & control*; D002648:Child; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000009:adverse effects; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012542:Scattering, Radiation; D013961:Thyroid Gland / Q000503:physiopathology* / Q000528:radiation effects