[Progression of lipopolysaccharide signal pathway].
Lipopolysaccharide (LPS) is the major constituents of the outer membrane of Gram-negative bacteria. LPS recognition and signal transmission are key events in the host defense reaction towards Gram-negative bacteria and are associated with many disorders. Multiple signaling pathways are involved in the response to LPS. With the help of LPS-binding protein and CD14, TLR4 binds with LPS, then recruits myeloid differentiation factor 88 and IL-1 receptor-associated kinase, and further phosphorylates and activates TNF receptor associated factor 6 (TRAF6). The activated TRAF6 leads to the activation of transcription factor NF-kappaB and MAP kinase's pathways that involves in LPS-induced cellular responses and the production of proinflammatory cytokines such as TNF-alpha, IL-6 and IL8.
Cancer Research Institute, Central South University, Changsha 410078, China.
Yi-xin
YX
Yang
Gui-yuan
GY
Li
D000209:Acute-Phase Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000737:chemistry*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D020929:Mitogen-Activated Protein Kinase Kinases; D016328:NF-kappa B; D000099231:Lipopolysaccharide-Binding Protein