Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury.
Hypoxia-induced mitogenic factor (HIMF), also known as FIZZ1 (found in inflammatory zone), plays important roles in lung inflammation. We found that intraperitoneal injection of lipopolysaccharide (LPS) induced intensive HIMF production exclusively in mouse lung, but not in the heart, liver, spleen or kidney. This HIMF production, at least partly, contributes to LPS-induced vascular cell adhesion molecule-1 (VCAM-1) upregulation and mononuclear cell sequestration to lung parenchyma, while protecting alveolar type II cells from LPS-resulted decrease in surfactant protein-C production and cell death. These data indicate that HIMF participates in LPS-induced acute lung injury and inflammation through modulating VCAM-1 and SP-C expression.
Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63110-0250, USA.
Qiangsong
Q
Tong
Liduan
L
Zheng
Qiaohua
Q
Kang
Jeffrey
J
Dodd-O
John
J
Langer
Bo
B
Li
Danming
D
Wang
Dechun
D
Li
D000208:Acute Disease; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D055370:Lung Injury; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D020932:Nerve Growth Factor / Q000096:biosynthesis; D009928:Organ Specificity / Q000187:drug effects; D010455:Peptides / Q000378:metabolism; D011014:Pneumonia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D011506:Proteins; D037721:Pulmonary Surfactant-Associated Protein C; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D015854:Up-Regulation / Q000187:drug effects*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis
D036341:Intercellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D010455:Peptides; D011506:Proteins; D037721:Pulmonary Surfactant-Associated Protein C; C413576:Retnla protein, mouse; C489680:Sftpc protein, mouse; D019010:Vascular Cell Adhesion Molecule-1; D020932:Nerve Growth Factor