[Study on the anti-cerebral ischemia/reperfusion injury effect and it's mechanisms of HD02].
OBJECTIVE
To study the effect of HD02 on Anti-Cerebral Ischemia/Reperfusion Injury.


METHODS
The mice cerebral Ischemia/Reperfusion models were randomly divided into three group: control group, I/R group and treating groups (different dosages of HD02). At the end of the experiment, brain tissues were harvested to measure the brain water content, SOD activity, MDA content and the activity of Na+/K+ -ATP and Ca2+ -ATP enzyme.


RESULTS
HD02 could obviously decrease the brain water content (P < 0.01) and the MDA content ( P < 0.01), while, it could also, increase the activity of SOD (P < 0.01) and the activity of ATP enzyme (P < 0.05). These data showed that there was sever oxidative damage in brain tissue and HD02 could prevent I/R injury in brain.
Zhao
Danyang
D
Guangzhou Children's Hospital, Guangzhou.
Zhao
Mingqi
M
Wu
Weikang
W
Zeng
Qiyi
Q
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D015427:Reperfusion Injury / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014867:Water / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014867:Water; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase