Macrolide prescriptions and erythromycin resistance of Streptococcus pyogenes.
This study shows a significant association between the number of macrolide prescriptions reimbursed by the Italian National Health Service and resistance of Streptococcus pyogenes to erythromycin in children from a region in northern Italy with high prevalence of erythromycin resistance. Recent prescription of a macrolide (especially azithromycin) is a predictor of erythromycin resistance, as well as a possible risk factor for resistance at a community level.
Gagliotti
Carlo
C
Agenzia Sanitaria Regionale Emilia-Romagna, Bologna, Italy. cgagliotti@regione.emilia-romagna.it
Nobilio
Lucia
L
Milandri
Milena
M
Moro
Maria Luisa
ML
D000293:Adolescent; D017963:Azithromycin / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007558:Italy; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013222:State Medicine; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000302:isolation & purification
D018942:Macrolides; D004917:Erythromycin; D017963:Azithromycin