Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime--a case report.
BACKGROUND
Paracetamol overdose is the most common drug overdose worldwide. To our knowledge, the maximum number of paracetamol tablets ingested reported in the literature is 45 g.


METHODS
We describe a 21-year-old patient who acutely ingested 120 tablets, each 500 mg paracetamol (i.e., 60 g equivalent to 1200 mg/kg body weight) in a suicidal attempt. Our patient also drank 2 bottles of codeine-based cough syrup equivalent to 360 mg of codeine. At 6 hours post ingestion, her serum paracetamol level was 207 mg/L. The poor prognostic factors for paracetamol overdose in our patient included massive paracetamol ingestion (confirmed by blood levels), codeine co-ingestion and elevated serum amylase (189 U/L).


METHODS
She was treated with a 3-day modified regimen of intravenous N-acetylcysteine.


RESULTS
The liver function tests and the prothrombin time remained normal over the second and third day of admission and the patient was discharged without complications on the fifth day.


CONCLUSIONS
From this experience we feel that in very severe paracetamol poisoning, a modified regime of intravenous N- acetylcysteine for 3 days is safe and efficacious.
Sule
Ashish A
AA
Department of General Medicine, Tan Tock Seng Hospital, Singapore.
Tai
Dessmon Y H
DY
Tze
Choong-Charn
CC
Deepa
Balakrishnan
B
Leow
Melvin Khee-Shing
MK
Leow
Melvin
M
D000082:Acetaminophen / Q000097:blood / Q000506:poisoning*; D000111:Acetylcysteine / Q000008:administration & dosage*; D000328:Adult; D000681:Amylases / Q000097:blood; D000931:Antidotes / Q000008:administration & dosage*; D003061:Codeine / Q000506:poisoning; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D009294:Narcotics / Q000506:poisoning; D013406:Suicide, Attempted; D013607:Tablets; D013997:Time Factors
D000931:Antidotes; D009294:Narcotics; D013607:Tablets; D000082:Acetaminophen; D000681:Amylases; D003061:Codeine; D000111:Acetylcysteine