The dasyscyphins A-C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus.
In the course of a screening for cytotoxic compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5-3 microg/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).
Institute of Biotechnology and Drug Research IBWF, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Viktor
V
Mierau
Veronica
V
Rojas de la Parra
Olov
O
Sterner
Timm
T
Anke
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004224:Diterpenes / Q000378:metabolism* / Q000494:pharmacology*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D019169:Jurkat Cells; D008826:Microbial Sensitivity Tests; D012334:RNA, Neoplasm / Q000096:biosynthesis; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D004224:Diterpenes; D012334:RNA, Neoplasm; C509641:dasyscyphin A; C509642:dasyscyphin B; C509643:dasyscyphin C; C509644:niveulone