Vecuronium in a patient with late cerebellar cortical atrophy.
Little information is available regarding the sensitivity to neuromuscular blocking drugs in patients with spinocerebellar degeneration and associated diseases. We report the response to vecuronium in a patient with late cerebellar cortical atrophy, a nonhereditary type of cerebellar ataxia. Onset time and time to 25% recovery of T1/T0 after vecuronium 0.1 mg.kg(-1) under sevoflurane anesthesia were 156 seconds and 43 minutes, respectively. Recovery index was 27 minutes. We believe this is the first report describing a response to neuromuscular blocking drugs in this disease.
Oikawa
Mihori
M
Department of Anesthesiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Nitahara
Keiichi
K
Shono
Shinjiro
S
Sakuragi
Tadakazu
T
Higa
Kazuo
K
D000368:Aged; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation; D001284:Atrophy; D002525:Cerebellar Cortex / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008738:Methyl Ethers; D016343:Monitoring, Intraoperative; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D013132:Spinocerebellar Degenerations / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects; D014673:Vecuronium Bromide
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D014673:Vecuronium Bromide