Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.
Lund University Medical Laser Centre, Lund, Sweden.
Marcelo Soto
MS
Thompson
Stefan
S
Andersson-Engels
Sune
S
Svanberg
T
T
Johansson
Sara
S
Palsson
Niels
N
Bendsoe
A
A
Derjabo
J
J
Kapostins
Unne
U
Stenram
J
J
Spigulis
Katarina
K
Svanberg
D000328:Adult; D000368:Aged; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D005260:Female; D005453:Fluorescence; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011524:Protoporphyrins / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy*
D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX