Controversy fuels trafficking of GPI-anchored proteins.
The model that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) take a direct transport route to the apical membrane of epithelial cells has recently been challenged. In this issue, Paladino et al. (p. 1023) and Hua et al. (p. 1035) show that the original view nevertheless holds. This closes a chapter in the winding story of GPI-AP trafficking but opens another phase, as the controversy has stimulated the development of new methodology.
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Sebastian
S
Schuck
Kai
K
Simons
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D006056:Golgi Apparatus / Q000502:physiology; D047569:Laser Scanning Cytometry; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology
D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins