From small building blocks to complex molecular architecture.
[reaction: see text] We describe a synthesis of a dendrimer-like amphiphile containing a flat rigid core and 12 hydrophobic and hydrophilic arms. We employ a modular approach based on stepwise protection chemistry starting from simple building blocks. The key feature of this approach is the absence of a polymerization step, which makes it applicable for linear monofunctionalized precursors of any kind. This strategy also allows for precise control of the number of arms and ensures their alternating arrangement.
Zubarev
Eugene R
ER
Department of Chemistry, Rice University, Houston, Texas 77005, USA. zubarev@rice.edu
Xu
Jun
J
Gibson
Jacob D
JD
Sayyad
Arshad
A