Hypercalcaemia associated with granulomatous lymphadenitis and elevated 1,25 dihydroxyvitamin D concentration in a dog.
A seven-year-old Labrador was presented with weight loss and mild generalised lymphadenopathy. Histopathology of an excised lymph node by the referring veterinarian demonstrated granulomatous lymphadenitis. At the time of referral, fine-needle aspirates of the lymph nodes confirmed the presence of ongoing granulomatous inflammation. Further investigations revealed marked hypercalcaemia, a low parathyroid hormone concentration, a parathyroid hormone related protein concentration within the reference range, and an elevated serum concentration of 1,25 dihydroxyvitamin D. An underlying cause of the granulomatous lymphadenitis could not be identified. The clinical signs, hypercalcaemia and elevated serum concentrations of 1,25 dihydroxyvitamin D resolved following prednisolone treatment. In contrast to dogs, hypercalcaemia occurred secondarily to granulomatous disease and elevated 1,25 dihydroxyvitamin D concentrations is a well-recognised condition in human beings. To the authors' knowledge, this is the first case report to describe elevated serum calcium and 1,25 dihydroxyvitamin D concentrations in a dog with histologically confirmed granulomatous disease.
Mellanby
R J
RJ
Queen's Veterinary School Hospital, University of Cambridge.
Mellor
P
P
Villiers
E J
EJ
Herrtage
M E
ME
Halsall
D
D
O'Rahilly
S
S
McNeil
P E
PE
Mee
A P
AP
Berry
J L
JL
D000818:Animals; D044963:Biopsy, Fine-Needle; D002117:Calcitriol / Q000097:blood*; D004283:Dog Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D006099:Granuloma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood; D015431:Weight Loss
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D013972:Thyrotropin; D002117:Calcitriol; D013974:Thyroxine