Clinical observation on influence of chinese medicines for promoting blood circulation to remove blood stasis on FIB and DD in plasma of patients with cerebral thrombosis.
OBJECTIVE
to study the influence of Chinese medicines for promoting blood circulation to remove blood stasis on fibrinogen (FIB) and D-dimer (DD) in plasma of patients with cerebral thrombosis.


METHODS
73 inpatients with acute cerebral thrombosis were randomly divided into a control group of 34 cases and a treatment group of 39 cases. The content of FIB and DD in plasma was detected before treatment and on the 7th and 14th days after treatment.


RESULTS
FIB content in plasma after treatment was lower than that before treatment in the control group (P<0.01) and more remarkable in the treatment group (P<0.001). There was an obvious difference in DD content before and after treatment in both groups. DD content on the 7th and 14th days after treatment in the treatment group was obviously higher than that in the control group (P<0.01 and P<0.05 respectively).


CONCLUSIONS
Chinese medicines for promoting blood circulation to remove blood stasis can reduce the FIB content in plasma of patients with cerebral thrombosis, raise the DD content in plasma, cause the peak of DD content appear earlier and obviously improve hypercoagulability of blood in patients with cerebral thrombosis.
People's Hospital Affiliated to Fujian Collage of Traditional Chinese Medicine, Fuzhou.
Hui
H
Liang
Su
S
Chen
Shaofang
S
Shen
D000368:Aged; D001775:Blood Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen