[Oxidatif-stress and COPD. Role of infection. Prevention].
For the next decade, COPD will become the third cause of mortality in the world. COPD is mainly due to cigarette smoking and presents different levels of severity according to people, probably linked to environmental and genetic factors, which are not well documented. Recent publications pointed out bacterial bronchial colonization and exacerbations of infectious origin as worsening factors through a pro-inflammatory effect and oxidative stress. This should lead to a comprehensive review of anti-infectious prevention tools and to discuss the role of prophylactic antibiotherapy and antioxidants.
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Service de Pneumologie, Clinique des Voies Respiratoires, Hôpital Larrey de Toulouse, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse cedex 09, France. leophonte.p@chu-toulouse.fr
Guérin
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Lebas
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Liard
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Boulanger
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D003140:Communicable Disease Control; D004777:Environment; D006801:Humans; D007239:Infections / Q000209:etiology*; D018384:Oxidative Stress / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects