Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres.
The purpose of this research was to investigate the effects of different concentrations of polymer and sucrose stearate, aluminum tristearate as dispersing agents on microsphere properties and performance. The yield values of microspheres were over the 78%, and the encapsulation efficiencies were found to be approximately 73%. Particle sizes of microspheres prepared with aluminum tristearate were between 76 and 448 microm, while that of the microspheres containing sucrose stearate were between 521 and 2000 microm. Morphological and physicochemical properties of microspheres were investigated by scanning electron micrography and differential scanning calorimetry (DSC). DSC analysis indicated that verapamil hydrochloride formed a solid solution with acrylic polymers. In vitro release studies were performed using the flow-through cell method. While approximately 80% of drug was released from the microspheres containing aluminum tristearate in 480 minutes, the same amount of drug was released from microspheres containing sucrose stearate in only 60 minutes. Chemical structures and concentrations of the dispersing agents were clearly effective on the physical properties of microspheres and their drug-release characteristics.
iHoroz
B Bahar
BB
Ankara University Faculty of Pharmacy, Department of Pharmaceutical tamer.baykara@pharmacy.ankara.edu.tr.
Kliçarslan
Müge
M
Yüksel
Nilüfer
N
Baykara
Tamer
T
D000180:Acrylic Resins / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D012995:Solubility; D013229:Stearic Acids / Q000008:administration & dosage*; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014700:Verapamil / Q000008:administration & dosage
D000180:Acrylic Resins; D013229:Stearic Acids; C018153:sucrose monostearate; C050528:Eudragit RS; C031183:stearic acid; D013395:Sucrose; D014700:Verapamil