COL1A1 Sp1 polymorphism associates with bone density in early puberty.
Optimal acquisition of bone mass in puberty is a key determinant of the lifetime risk of osteoporosis and has a strong genetic basis. We investigated the relationship between the COL1A1 Sp1 polymorphism and BMD in early puberty, and how the genotypes relate to bone size and geometry as well as bone turnover and material properties in 247 10- to 13-year-old girls. Bone properties were measured using DXA, pQCT, and ultrasound. Also, serum P1NP, OC, B-ALP, and TRACP 5b were assessed. Our results showed that girls with the TT genotype had significantly lower BMC and BMD of the total body, lumbar spine, and proximal femur, as well as BUA at the calcaneus, than those with the GT and GG genotype. They also had significantly lower B-ALP, as well as P1NP/TRACP 5b and (OC + B-ALP)/TRACP 5b, compared to the others. These findings indicate that the COL1A1 polymorphism is associated with low bone properties in early puberty and suggest a possible physiological effect on collagen metabolism and bone turnover. This information may contribute to the identification of children at risk for suboptimal acquisition of peak bone mass and may ultimately be of value in the planning of early preventive strategies for osteoporosis.
Department of Cell Biology, University of Jyväskylä, Jyväskylä, Finland.
Miia
M
Suuriniemi
Vuokko
V
Kovanen
Anitta
A
Mahonen
Markku
M
Alén
Qingju
Q
Wang
Arja
A
Lyytikäinen
Sulin
S
Cheng
D000293:Adolescent; D015415:Biomarkers; D015519:Bone Density / Q000235:genetics*; D002648:Child; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011629:Puberty, Precocious / Q000235:genetics* / Q000473:pathology*; D013997:Time Factors
D015415:Biomarkers; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain