Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) co-administrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250-1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro. svukovic@med.bg.ac.yu
Sonja
S
Vuckovic
Maja
M
Tomic
Radica
R
Stepanovic-Petrovic
Nenad
N
Ugresic
Milica
M
Prostran
Bogdan
B
Boskovic
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology*; D003208:Concanavalin A; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D007249:Inflammation; D008297:Male; D010146:Pain / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014110:Touch; D014970:Xanthines / Q000494:pharmacology
D000700:Analgesics; D043682:Receptor, Adenosine A1; D014970:Xanthines; D003208:Concanavalin A; D002220:Carbamazepine; D002110:Caffeine; C051360:1,3-dipropyl-8-cyclopentylxanthine