DDQ-mediated direct cross-dehydrogenative-coupling (CDC) between benzyl ethers and simple ketones.
A direct Cross-Dehydrogenative-Coupling (CDC) between benzyl ethers and simple ketones was developed without using any metal catalyst. By using DDQ, various benzyl ethers and simples ketones were coupled together directly to form beta-alkoxyl ketones efficiently. A mechanism in which the DDQ serves the double roles of an oxidizing agent and an organomediator was proposed.
Zhang
Yuhua
Y
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Li
Chao-Jun
CJ