A facile and efficient direct aldol addition of simple thioesters.
[reaction: see text] Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr(2).OEt(2) and i-Pr(2)NEt using untreated, reagent-grade CH(2)Cl(2) under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.
Yost
Julianne M
JM
Department of Chemistry and the Center for Chemical Biology, Duke University, Durham, North Carolina 27708, USA.
Zhou
Guoqiang
G
Coltart
Don M
DM