Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles.
Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5-10) allowed the determination of pK(a) = 2.0, showing that this compound may be useful as a pH indicator for pH < or = 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.
Castanheira
Elisabete M S
EM
Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. ecoutinho@fisica.uminho.pt
Pinto
Ana M R
AM
Queiroz
Maria-João R P
MJ
D000890:Anti-Infective Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D005453:Fluorescence; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D008081:Liposomes; D012996:Solutions; C517096:benzothienopyridopyrimidone