[Protective effects of the granule of Sambucus chinensis lindl on acute hepatic injury].
OBJECTIVE
To investigate the protective effects of the granule of Sambucus chinensis Lindl on acute hepatic injury.


METHODS
The acute liver-injury model induced by CCl4 or D-GalN or ConA was established in mice or rats.


RESULTS
The granule of Sambucus chinensis Lindl showed significantly protective effects on mice acute hepatic injury induced by CCl4 ,and the effects were concern of antagonizing lipoperoxidation and improving energy of Ca2+ -ATPase of theca mitochondria and microsome. It showed significantly protective effects on mice or rats acute hepatic injury induced by D-GalN or Con A, too.


CONCLUSIONS
The granule of Sambucus chinensis Lindl showed significantly protective effects against many kinds of chemical and immunological liver injuries.
School of Pharmacology, Shenyang Pharmaceutical University, Shenyang.
Wei
W
Yang
Xisha
X
Wang
Minwei
M
Wang
Yan
Y
Xu
Ding
D
Lu
Changsheng
C
Liu
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D003208:Concanavalin A; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D027923:Sambucus / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D000637:Transaminases / Q000097:blood
D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D003208:Concanavalin A; D008315:Malondialdehyde; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase