[Parathyroid carcinoma].
Parathyroid carcinoma is a rare disease accounting for 1 to 5% of parathyroid neoplasms. This malignant tumour must be suspected when a severe primary hyperparathyroidism occurs with high hypercalcemia and elevated parathormon levels. At this time, a cervical mass is often palpable. Both head and neck ultrasonography and 99mTc-sestamibi scintigraphy are the best preoperative imaging tests to suspect and localize the tumour. Surgical approach with simultaneous tumorectomy and hemithyroidectomy, completed by selective neck dissection (level VI) is the treatment of choice. An elective lateral neck dissection should be performed if necessary. Tumour control should be monitored by regular measurement of calcium and parathormon levels. Local recurrence or metastasis risk is 30 to 70% and the 5 year overall survival about 50 to 80%. In case of recurrence, aggressive surgical management should be applied and adjuvant radiation therapy may be discussed.
Poissonnet
Gilles
G
Service d'ORL et de chirurgie de la face et du cou, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189 Nice Cedex 2. gilles.poissonnet@cal.nice.fnclcc.fr
Castillo
Laurent
L
Bozec
Alexandre
A
Peyrottes
Isabelle
I
Ettore
Francette
F
Santini
José
J
Demard
François
F
Dassonville
Olivier
O
D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D006961:Hyperparathyroidism / Q000209:etiology; D010282:Parathyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000628:therapy