Activity of lysosomal exoglycosidases in the serum of patients with chronic Lyme arthritis.
To examine the role of lysosomal exoglycosidases in the pathogenesis of Lyme arthritis we studied a group of 18 patients aged 18-72 (mean: 46 yr) diagnosed with chronic arthritis in the course of borreliosis. The control group was composed of 20 healthy volunteers (health service employees) aged 25-65 (mean: 45 yr) with no detectable serum anti-Borrelia burgdorferi antibodies. We found that N-acetyl-beta-d-hexosaminidase (HEX) was significantly increased and beta-galactosidase and alpha-mannosidase also showed an increase in Lyme arthritis patients compared to healthy persons and normalised after treatment with doxycycline. Our results suggest that HEX is a sensitive enzymatic marker of Lyme arthritis and it may be used to monitor the course of the disease and the efficiency of treatment.
Pancewicz
Slawomir A
SA
Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Zurawia 14, PL-15540 Białystok, Poland. spancewicz@interia.pl
Wielgat
Przemyslaw
P
Hermanowska-Szpakowicz
Teresa
T
Kondrusik
Maciej
M
Zajkowska
Joanna
J
Grygorczuk
Sambor
S
Popko
Janusz
J
Zwierz
Krzysztof
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D008193:Lyme Disease / Q000097:blood / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008875:Middle Aged; D043323:alpha-Mannosidase / Q000097:blood; D001616:beta-Galactosidase / Q000097:blood; D001619:beta-N-Acetylhexosaminidases / Q000097:blood*
D001616:beta-Galactosidase; D043323:alpha-Mannosidase; D001619:beta-N-Acetylhexosaminidases