Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches.
The aim of the study was to evaluate the efficacy of aglepristone (10 mg/kg on days 1, 2 and 8) for the treatment of metritis or pyometra in bitches (n = 67) either alone for cases of metritis (n = 15), or in cases of pyometra (n = 52) with (n = 32) or without (n = 20) the addition of low doses (1 microg/kg) of cloprostenol for 5 days (days 3-7). Examinations performed on day 90, in addition to days 8, 14 and 28, determined that treatments had been curative in the long term in 54/67 bitches (80.6%). Bitches in whom pyometra did not resolve, were given additional aglepristone on day 14 (n = 38) and day 28 (n = 20). Aglepristone alone was curative in 15/15 bitches with metritis. In 17/17 bitches with closed pyometra, cervical opening occurred within 48 h of aglepristone administration. Amongst the 52 bitches with open (n = 35) or closed (n = 17) pyometra, the additional treatment with cloprostenol from days 3 to 7, significantly improved the overall success rate at day 90, which was 27/32 (84.4%), compared to 12/20 (60.0%) in bitches without cloprostenol (P < 0.05). The leucocyte count and plasma progesterone concentrations significantly decreased over the course of treatment. Thirteen of 15 bitches in whom plasma progesterone concentrations were initially low (< 3.18 nmol/L) were cured. The recurrence rate after 12 and 24 months was 13.0% (3/23) and 19.0% (4/21), respectively.
Laboratory of Biotechnology and Pathology of Reproduction, National Veterinary School, BP 40706, 44307 Nantes Cedex 03, France. fieni@vet-nantes.fr
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D000818:Animals; D003008:Cloprostenol / Q000627:therapeutic use*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D004359:Drug Therapy, Combination; D004714:Endometrial Hyperplasia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000662:veterinary*; D004716:Endometritis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary; D004963:Estrenes / Q000627:therapeutic use*; D005260:Female; D007958:Leukocyte Count / Q000662:veterinary; D011374:Progesterone / Q000097:blood; D014591:Uterine Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary
D004963:Estrenes; C419063:aglepristone; D003008:Cloprostenol; D011374:Progesterone