Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using differential scanning calorimetry and X-ray powder diffractometry.
Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) methods were developed for the quantitative analysis of the crystallinity of indomethacin (IMC) in IMC and silica gel (SG) binary system. The DSC calibration curve exhibited better linearity than that of XRPD. No phase transformation occurred in the IMC-SG mixtures during DSC measurement. The major sources of error in DSC measurements were inhomogeneous mixing and sampling. Analyzing the amount of IMC in the mixtures using high-performance liquid chromatography (HPLC) could reduce the sampling error. DSC demonstrated greater sensitivity and had less variation in measurement than XRPD in quantifying crystalline IMC in the IMC-SG binary system.
Pan
Xiaohong
X
School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA. xpan100_2000@yahoo.com
Julian
Thomas
T
Augsburger
Larry
L
D002138:Calibration; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D033362:Powder Diffraction; D015203:Reproducibility of Results; D058428:Silica Gel; D012822:Silicon Dioxide / Q000008:administration & dosage*; D014961:X-Ray Diffraction
D058428:Silica Gel; D012822:Silicon Dioxide; D007213:Indomethacin