Abusive prescription of psychostimulants: a study of two cases.
Because psychostimulants have serious possible side effects and particular potential for abuse, their therapeutic indications are today exclusively limited to disorders such as obesity, narcolepsy, or attention deficit/hyperactivity disorder. We report two cases of abusive prescription of these drugs. The first concerns a woman who was treated for a 3 kg weight gain with fenproporex for 5 years and presented a withdrawal syndrome when this drug was no longer marketed in France. In the second case, a woman who complained of atypical sleep problems was prescribed modafinil, methylphenidate, clobazam, lormetazepam, meprobamate, and aceprometazine, and was found dead in her home a few weeks later in unexplained circumstances. For these two patients, neither the indications, nor the contraindications, nor the prescribing rules for these restricted drugs had been complied with. This case report highlights the extreme danger of these substances and stresses the importance of adhering to the rules of prescription.
Service de Médecine Légale, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France. anne-laure.pelissier@mail.ap-hm.fr
Anne-Laure
AL
Pélissier-Alicot
Marie-Dominique
MD
Piercecchi-Marti
Christophe
C
Bartoli
Erika
E
Kuhlmann
Philippe-Emmanuel
PE
Coiffait
Alain
A
Sanvoisin
Dominique
D
Giocanti
Georges
G
Léonetti
D000328:Adult; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D006970:Disorders of Excessive Somnolence / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D019966:Substance-Related Disorders / Q000209:etiology*; D013406:Suicide, Attempted
D000697:Central Nervous System Stimulants