Pregnancy in a patient of Glanzmann's thrombasthenia.
Glanzmann's thrombasthenia is a congenitally acquired platelet disorder with an autosomal recessive mode of inheritance. Though, quantitatively normal, the aggregation ability of platelets is reduced in this condition. Pregnancy and delivery are rare in these patients and have been associated with a high risk of severe post-partum hemorrhage. We describe a primigravida, who was diagnosed to have Glanzmann's thrombasthenia during adolescence. She developed secondary post-partum hemorrhage after an elective caesarean section, which was successfully managed by single donor platelet transfusion.
Department of gynecology and obstetrics,All India Institute of medical sciences, New Delhi, India. charuchanana@rediffmail.com
Neena
N
Malhotra
Charu
C
Chanana
Deepika
D
Deka
D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010359:Patient Readmission; D017713:Platelet Transfusion; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D049590:Postpartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011295:Prenatal Care; D018570:Risk Assessment; D012307:Risk Factors; D013915:Thrombasthenia / Q000150:complications* / Q000628:therapy; D014148:Tranexamic Acid / Q000627:therapeutic use
D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid