[Coeliac disease and reproduction: possible in vivo models].
Presently there are no in vivo models to study the different effects of coeliac disease (CD) including the increase of reproductive risks. CD is a multifactorial condition which requires both an exogenous element (gluten) and complex genetic factors; moreover, CD is associated to several endocrine, immune and reproductive diseases. There are no adequate in vivo models for the systemic complications of CD; in particular, there are no genetic knock-out models. However, models are available for gluten enteropathy such as Irish Setter and Balb/c and BDF1 mouse strains, and also for endocrine-immune diseases associated to CD such as BB rats and NOD mice. These models could be used to study reproductive aspects. This is desirable because a new model for dermatitis herpetiformis tightly associated with CD, that uses HLA-DQ8 transgenic NOD mice, has already been identified.
Stazi
Anna Velia
AV
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Roma. avelia@iss.it
D000818:Animals; D002446:Celiac Disease / Q000150:complications* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000209:etiology; D004285:Dogs; D004700:Endocrine System Diseases / Q000209:etiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D020022:Genetic Predisposition to Disease; D005831:Genital Diseases, Female / Q000209:etiology* / Q000503:physiopathology; D005832:Genital Diseases, Male / Q000209:etiology* / Q000503:physiopathology; D005983:Glutens / Q000009:adverse effects; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007246:Infertility / Q000209:etiology; D007408:Intestinal Absorption; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D008822:Mice, Transgenic; D010024:Osteoporosis / Q000209:etiology; D010641:Phenotype; D051381:Rats; D011913:Rats, Inbred BB
D012739:Gonadal Steroid Hormones; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen; D005983:Glutens