Osteoarthritis susceptibility loci defined by genome scan meta-analysis.
Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P (sumrnk) =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-Dong Seongbuk-Ku, Seoul 136-705, South Korea. lyhcgh@korea.ac.kr
Young Ho
YH
Lee
Young Hee
YH
Rho
Seong Jae
SJ
Choi
Jong Dae
JD
Ji
Gwan Gyu
GG
Song
D002897:Chromosomes, Human, Pair 7; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000235:genetics*