Paraneoplastic rhombencephalitis and brachial plexopathy in two cases of amphiphysin auto-immunity.
Amphiphysin, a synaptic vesicle protein, is an auto-immune target in rare cases of paraneoplastic neurological disorders. We report two additional cases with distinct neurological syndromes and paraneoplastic anti-amphiphysin antibodies. The first patient, a 59-year-old man, presented with cerebellar and cranial nerve dysfunction and small cell lung carcinoma. The second, a 77-year- old woman, presented with left brachial plexopathy followed by sensorimotor neuropathy and breast carcinoma.
Coppens
T
T
Service de Neurologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique.
Van den Bergh
P
P
Duprez
T J
TJ
Jeanjean
A
A
De Ridder
F
F
Sindic
C J M
CJ
D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D001917:Brachial Plexus / Q000276:immunology / Q000473:pathology; D020516:Brachial Plexus Neuropathies / Q000175:diagnosis* / Q000276:immunology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000276:immunology; D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000276:immunology; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000276:immunology; D004660:Encephalitis / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009460:Neurologic Examination; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology; D012249:Rhombencephalon / Q000276:immunology / Q000473:pathology; D014057:Tomography, X-Ray Computed
D009419:Nerve Tissue Proteins; C075637:amphiphysin