Role reversal: brain insulin and liver STAT3.
The central nervous system (CNS) actions of several hormones, including insulin, regulate metabolism in the liver and other peripheral tissues. Inoue et al. (2006) have now identified an IL-6/STAT3-dependent pathway in the liver that mediates a portion of the hepatic metabolic response to CNS insulin.
Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Martin G
MG
Myers
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004789:Enzyme Activation; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006706:Homeostasis; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000378:metabolism; D007728:Kupffer Cells / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010730:Phosphoenolpyruvate Carboxylase / Q000378:metabolism; D010766:Phosphorylation; D011972:Receptor, Insulin / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
D007328:Insulin; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D011972:Receptor, Insulin; D005952:Glucose-6-Phosphatase; D010730:Phosphoenolpyruvate Carboxylase; D005947:Glucose