[Studies on antitumor effects of podophyllotoxin nanoliposome].
OBJECTIVE
To compare the antitumor effects of the podophyllotoxin nanoliposome and the suspensions of podophyllotoxin in bearing-tumor mice.


METHODS
The experimental mice were inoculated by suspension liquid of tumor cell in axillary region near the forelimb, 0.2 mL each. The mice had been randomly divided into 8 groups 24 h latter. The podophyllotoxin nanoliposome, suspension liquid of the podophyllotoxin, CX or NS was given to each group respectively. Except CX was given by celiac injection once, the other groups were injected every 4 days for three times. The mice were killed by hauling necks on the twelfth day after treatment, the tumor was weighed and the inhibitory rate was calculated.


RESULTS
When the dosage of podophyllotoxin nanoliposome and the suspensions of podophyllotoxin reached 5.0 mg x kg(-1), the rate of inhibiting tumor were 52.37% and 38.25% to the H22 liver cancer of mice respectively.


CONCLUSIONS
Podophyllotoxin nanoliposome and the suspensions of podophyllotoxin have the effect in anti-liver cancer. And podophyllotoxin nanoliposome have stronger inhibitory rate compared with suspension liquid of the podophyllotoxin in same dose.
Department of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Xiao-Yun
XY
Zhang
Jing-Man
JM
Ni
Hua
H
Qiao
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008081:Liposomes; D008113:Liver Neoplasms / Q000473:pathology*; D051379:Mice; D049329:Nanostructures; D009368:Neoplasm Transplantation; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
D000972:Antineoplastic Agents, Phytogenic; D008081:Liposomes; D011034:Podophyllotoxin