[Study on reflux esophagitis treated by Tongjiang granule].
OBJECTIVE
To study the mechanism of Tongjiang granule on treating GERD.


METHODS
The rats in the model group received steel wire ring-cardiamyopexy. A steel wire ring was fixed firmly on cardia. The rats in the control group underwent the cardia-plasty plus pylori ligation plus stomach-empty intestine Roux-en-Y anastomosis. The rats were divided into six groups after operations at random, which were fed up respectively with Tongjiang granule of different dosage and perpulsid. No treatment groups were taken as control.


RESULTS
The experiment showed that Tongjiang granule could lighten or cure RE in the pathology, decrease the hydrochloric acid in gastric juice, in the meantime, increase the motilin in the animal blood. This study indicated that the effect of Tongjiang granule group from experimental research was better than that of the control group (perpulsid).


CONCLUSIONS
The effects of Tongjiang granule on treating GERD can be achieved by decreasing the hydrochloric acid in gastric juice, increasing the motilin in blood and promoting the gastric impetus in the animal experiment.
Tang
Xu-Dong
XD
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. txdly@sina.com.cn
Wu
Hong-Mei
HM
Wang
Zhi-Bin
ZB
Shao
Yan
Y
Hu
Yu-Chi
YC
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000187:drug effects*; D006851:Hydrochloric Acid / Q000378:metabolism*; D008297:Male; D009037:Motilin / Q000097:blood*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009037:Motilin; D006851:Hydrochloric Acid