Recent developments in the treatment of atherosclerosis.
Atherosclerosis is one of the most frequent causes of cardiac arrest. The major cause of this disease is high concentrations of lipid in the blood. Medicinal agents so far have been quite successful in the management of hyperlipidemia. Among the several widely used drugs, (fibrates, statins and niacin) statins are the most frequently prescribed in many forms of hyperlipidemia. Recently, statins have been found to produce serious toxicities, which are rare but can be potentially harmful and are noise concern for the immediate need to develop some new chemical entities in this category. This review is primarily concerned with recent developments in atherosclerotic drug discovery including novel inhibitors of cholesterol biosynthesis, cholesterol absorption inhibitors and antioxidants. The review also focuses on possible future targets including gene therapy.
Department of Pharmaceutical Chemistry, L.M. College of Pharmacy, Navrangpura, Ahmedabad - 380009, Gujarat, India. pathik26@yahoo.com
Pathik S
PS
Brahmkshatriya
Mitesh H
MH
Jani
Mahesh T
MT
Chhabria
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D008074:Lipoproteins / Q000187:drug effects / Q000378:metabolism
D000924:Anticholesteremic Agents; D008074:Lipoproteins; D002784:Cholesterol