[Treatment of infantile spasms].
Infantile spasms (IS) are characterised by neurodevelopmental regression, a unique type of seizures and a hypsarrhythmic EEG pattern. Studies recommend the medical treatment of IS as a positive short-term outcome with respect to the spasms and in the resolution of the hypsarrhythmia. However, the data are insufficient to recommend medical treatment with respect to improving the long-term outcome. The adrenocorticotropic hormone and prednisolone are recommended for treatment of IS, although side effects are common. Vigabatrin is also recommended; IS caused by tuberous sclerosis seems to respond especially well.
Odense Universitetshospital, Paediatrisk Afdeling H, Odense C. lars.kjaersgaard@dadlnet.dk
Lars Kjaersgård
LK
Hansen
Niels Henrik
NH
Rasmussen
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000927:Anticonvulsants / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D011379:Prognosis; D013036:Spasms, Infantile / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D020888:Vigabatrin / Q000008:administration & dosage
D000927:Anticonvulsants; D000324:Adrenocorticotropic Hormone; D020888:Vigabatrin