Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk nuclear test site.
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.
Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
Nobuo
N
Takeichi
Masaharu
M
Hoshi
Shozo
S
Iida
Kimio
K
Tanaka
Yuka
Y
Harada
Zhaxybay
Z
Zhumadilov
Nailya
N
Chaizhunusova
Kazbek N
KN
Apsalikov
Yoshihiro
Y
Noso
Toshiya
T
Inaba
Kenichi
K
Tanaka
Satoru
S
Endo
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle / Q000706:statistics & numerical data; D002467:Cell Nucleus / Q000473:pathology* / Q000528:radiation effects*; D002648:Child; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D007623:Kazakhstan / Q000453:epidemiology; D008214:Lymphocytes / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D015162:Micronucleus Tests / Q000706:statistics & numerical data; D008875:Middle Aged; D009689:Nuclear Warfare / Q000706:statistics & numerical data; D011832:Radiation Injuries / Q000453:epidemiology* / Q000235:genetics; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013961:Thyroid Gland / Q000473:pathology* / Q000528:radiation effects*