Dorsal hippocampus function in learning and expressing a spatial discrimination.
Learning to discriminate between spatial locations defined by two adjacent arms of a radial maze in the conditioned cue preference paradigm requires two kinds of information: latent spatial learning when the rats explore the maze with no food available, and learning about food availability in two spatial locations when the rats are then confined in one arm with food and the other with no food. Previous research showed that a functional dorsal hippocampus is not required for latent learning. The present experiments show that it is required for learning about food availability, and during retrieval of both types of information.
Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada. norman.white@mcgill.ca
Norman M
NM
White
Stephane
S
Gaskin
D000704:Analysis of Variance; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D018755:GABA Agonists / Q000008:administration & dosage; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D009118:Muscimol / Q000008:administration & dosage; D051381:Rats; D012054:Reinforcement, Psychology; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology*
D018755:GABA Agonists; D009118:Muscimol