Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases alpha and beta and human terminal deoxynucleotidyl transferase (TdT).
Doncaster
Jeremy R
JR
The School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Etchells
Laura L
LL
Kershaw
Neil M
NM
Nakamura
Ryoichi
R
Ryan
Hazel
H
Takeuchi
Ryo
R
Sakaguchi
Kengo
K
Sardarian
Ali
A
Whitehead
Roger C
RC
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship
D001688:Biological Products; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D004253:DNA Nucleotidylexotransferase; D004259:DNA-Directed DNA Polymerase