[Impact on the model of rat osteoarthritis of jingu tablet].
OBJECTIVE
To observe the influence of Jingu tablet (JGT) on the development and repair of osteoarthritis (OA).


METHODS
The admixture of 4% papain and 0.3 mol x L(-1) cysteine was injected into the rat's knee joint to make the model of rat OA, and distilled water, Gucining Capsule and JGT was given ig simultaneously to treat for 4 weeks in succession, and then animals were killed to measure every index.


RESULTS
JGT could obviously improve the scope of activities of knee joint. There were significant differences between every dosage group and model group. In every dosage group, JGT could suppress the swelling of thickness of slippery membrane of joint, alleviate the inflammation symptoms of OA and obviouslical improve the pathologicol changes of slippery membrane and cartilage. JGT could also obviously reduce the content of MDA of slippery membrane and lighten the degree of cell damage.


CONCLUSIONS
JGT can lighten the retrograde affection of joint cartilage, obviously suppress the slippery membrane's inflammation and alleviate the scathing degree of cell. Therefore JGT has definite remedial effect to OA.
College of Pharmacy, Hunan College of Traditional Chinese medicine, Changsha 410007, China.
Jian-Sheng
JS
Guo
Li
L
Ou
Jun
J
Zhou
Xiao-Juan
XJ
Wang
Xuan
X
Guo
D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D003545:Cysteine; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D010003:Osteoarthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010206:Papain; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013583:Synovial Membrane / Q000473:pathology*; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D010206:Papain; D003545:Cysteine