Endoscopic plication of massively bleeding peptic ulcer by using the Eagle Claw VII device: a feasibility study in a porcine model.
OBJECTIVE
We examined the efficacy of endoscopic plication when using Eagle Claw VII in a porcine bleeding ulcer model. ANIMAL MODEL PREPARATION: The right gastroepiploic artery (diameter 1.5-2 mm) was isolated and was tunneled to small gastrotomies at either the lesser or greater curvature of the stomach.


METHODS
We applied the Eagle Claw VII to achieve hemostasis.


METHODS
The survival of the pigs after endoscopic plication for hemostasis, time to achieve hemostasis with Eagle Claw VII, recurrent bleeding, number of successful plication, and number of suture remained.


RESULTS
Endoscopic plication was performed on bleeding gastric ulcers in 6 pigs. The time to achieve hemostasis was 6 minutes 56 seconds +/- 3 minutes 50 seconds. There was no complication. A total of 14 plications were performed. All animals survived for 1 week without recurrent bleeding. At the postmortem, 10 of the plication sutures remained.


CONCLUSIONS
Our model cannot simulate the chronicity of peptic ulcer.


CONCLUSIONS
In this porcine model, the Eagle Claw VII effectively stopped bleeding from arteries 2 mm in size.
Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.
Philip W Y
PW
Chiu
Bing
B
Hu
James Y W
JY
Lau
Lawrence C L
LC
Sun
Joseph J Y
JJ
Sung
Sydney S C
SS
Chung
D000818:Animals; D004195:Disease Models, Animal; D016099:Endoscopy, Gastrointestinal; D005240:Feasibility Studies; D018662:Fundoplication / Q000379:methods*; D016558:Hemostasis, Endoscopic / Q000379:methods*; D010438:Peptic Ulcer Hemorrhage / Q000628:therapy*; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000628:therapy*; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine; D016896:Treatment Outcome