[Vascular development and cartilage formation].
During endochondral bone formation, resistance to vascular invasion changes in association with differentiation and maturation of chondrocytes. Just prior to chondrogenesis, the vasculature regresses and avascular cartilaginous bone primodia appear. The anti-angiogenic barrier of cartilage is acquired through coordinate interactions of extracellular matrices and angiogenesis inhibitors. In the process of vascular invasion into cartilage, angiogenesis stimulators and matrix degrading enzymes play important roles. In this review, the association of angiogenesis with endochondral bone formation will be discussed.
Institute for Frontier Medical Sciences, Kyoto University, Department of Cellular Differentiation.
Chisa
C
Shukunami
D020533:Angiogenesis Inhibitors / Q000502:physiology; D000818:Animals; D002356:Cartilage / Q000098:blood supply*; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology*; D020219:Chondrogenesis; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D018919:Neovascularization, Physiologic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000502:physiology; D011506:Proteins / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D020533:Angiogenesis Inhibitors; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011506:Proteins; D042461:Vascular Endothelial Growth Factor A; D020782:Matrix Metalloproteinases