Overcoming barriers to long-term graft survival.
Although short-term kidney graft survival has improved in recent years, the focus has shifted to the challenge of improving long-term graft survival. Acute rejection, chronic allograft nephropathy, and cardiovascular disease are associated with graft loss and patient death. Reducing the potential for such posttransplantation complications may improve long-term graft survival. In addition, gaining a better understanding of the role that various immunosuppressive therapies have in decreasing the risk for graft injury will help clinicians make better-informed decisions about appropriate treatment regimens for individual kidney transplant recipients.
Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612-7315, USA. Kaplanb@uic.edu
Bruce
B
Kaplan
D000208:Acute Disease; D002908:Chronic Disease; D006084:Graft Rejection / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects
D007166:Immunosuppressive Agents