Cytokines in atopic diseases: revisiting the Th2 dogma.
In the field of allergic diseases, extensive research has demonstrated the implication of a strong TH2 activation that both initiates and maintains in situ inflammation with the help of TH2 cytokines. However, as anti-TH2 cytokines therapy is not sufficient to suppress the disease, a more complex immunological mechanism is suspected. In this review, we will revisit the TH2 dogma in allergic diseases, propose a possible implication of TH1 inflammation correlated with the severity of atopic disease, to conclude with the therapeutic solutions envisaged.
Mamessier
Emilie
E
UPRES 3287, Pathologie respiratoire liée à l'environnement, Faculté de médecine, 27, Boulevard Jean Moulin, 13285 Marseille, France. emilie.mamessier@medecine.univ-mrs.fr
Magnan
Antoine
A
D016207:Cytokines / Q000502:physiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines