Impact of an information booklet on satisfaction and decision-making about BRCA genetic testing.
The aim of this study was to assess the impact of a standardized patient information booklet on decisions women make about genetic testing. This French national multi-centre survey included all women with cancer to whom genetic testing for BRCA1/2 mutation had been proposed. The control group was surveyed before the booklet became available (n = 263), and the experimental group, after being given it personally (n = 297). After multivariate adjustment, the booklet had a positive impact on satisfaction with the information provided (Odds ratio (OR) = 2.9; 99% confidence interval (CI) = 1.7-5.0; P = 0.001), decreased the decisional conflicts due to lack of information (OR = 1.9; 99% CI = 1.1-3.3; P = 0.002), and had a marginal impact on knowledge (R2-gain = 3%; P = 0.001). The women in the experimental group decided more frequently to undergo testing (99% vs. 95%; P = 0.009). In addition to a consultation providing more tailored information, a standardized written document improved the decision-making process involved in giving informed consent to genetic testing.
Mancini
Julien
J
INSERM, UMR379, Institut Paoli-Calmettes, Epidemiology and Social Sciences Unit, 232 Bd Ste Marguerite, Marseille F-13000, France.
Noguès
Catherine
C
Adenis
Claude
C
Berthet
Pascaline
P
Bonadona
Valerie
V
Chompret
Agnès
A
Coupier
Isabelle
I
Eisinger
François
F
Fricker
Jean-Pierre
JP
Gauthier-Villars
Marion
M
Lasset
Christine
C
Lortholary
Alain
A
N'Guyen
Tan Dat
TD
Vennin
Philippe
P
Sobol
Hagay
H
Stoppa-Lyonnet
Dominique
D
Julian-Reynier
Claire
C
D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology; D016022:Case-Control Studies; D003376:Counseling / Q000379:methods* / Q000592:standards; D003657:Decision Making; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics / Q000523:psychology; D010174:Pamphlets; D010353:Patient Education as Topic / Q000379:methods* / Q000592:standards; D017060:Patient Satisfaction; D010817:Physician-Patient Relations; D011446:Prospective Studies; D011795:Surveys and Questionnaires