Dynamics of density- and frequency-dependent selection.
The evolution of a multiallelic locus in a diploid monoecious population is investigated for weak selection in both discrete and continuous time. It is assumed that in the absence of selection the rate of change of population size N is a function only of N, and N converges exponentially to a unique, globally stable equilibrium, ;N. With arbitrary density- and frequency-dependent selection, after several generations have elapsed, N differs from ;N by terms of O(s) (i.e., bounded by a constant times s), where s is the selection intensity. The mean absolute fitness deviates from its equilibrium value (1 in discrete, 0 in continuous time) by only O(s(2)); its rate of change is O(s(3)). The evolution of the gene frequencies may be approximated with an error of O(s) by assuming that N = ;N and Hardy-Weinberg proportions obtain. When the frequency dependence is weaker than the selection intensity, the mean absolute fitness generally exceeds its equilibrium value by a quantity approximately proportional to the genic variance, the constant of proportionality being simply related to the rate of convergence of N to ;N in the absence of selection. Thus, after a short time, the population generally increases, and the rate of growth is proportional to the genic variance.
Nagylaki
T
T
Department of Biophysics and Theoretical Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637.