Migraine drug therapy: dental implications.
Triptan drugs continue to constitute the major pharmacotherapeutic interventional agents for migraine therapy. Interactions of dental drugs with migraine medications are limited, but their seriousness dictates that dentists be aware of the use of ergot alkaloids, triptans, or other migraine drugs. While many migraine sufferers avoid dental therapy dur ing migraine attacks, the practitioner who is treating a patient who has taken migraine medications must carefully monitor the cardiovascular status of the patient, which may affect the use of vasoconstrictors. Macrolide antibiotics and azole antifungals represent additional drug groups that are prescribed by dentists but which may potentiate the adverse effects of migraine drugs. Migraine patients prefer agents that offer rapid onset of relief and total relief within a couple hours of drug administration; they also prefer therapy that prevents recurrences and does not require "rescue" medications, and, of course, a lack of adverse effects and interactions with other medications. Currently, no single drug or class of drugs offers this ideal combination of actions in all patients.
Department of Restorative Dentistry and Biomaterials, University of Texas Dental Branch, Houston, USA.
Arthur H
AH
Jeske
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017742:Dental Care for Chronically Ill; D004347:Drug Interactions; D004876:Ergot Alkaloids / Q000627:therapeutic use; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D014363:Tryptamines / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004876:Ergot Alkaloids; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D014363:Tryptamines