Simultaneous determination of endocrine-disrupting phenols and steroid estrogens in sediment by gas chromatography-mass spectrometry.
A simple and effective method has been developed to simultaneously determine endocrine-disrupting phenolic xenoestrogens and steroid estrogens in sediment by using ultra-sonicated extraction in combination with silica gel fractionation, derivatization with pentafluropropionic anhydride, and gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring mode (SIM). Satisfactory recoveries have been obtained for phenolic xenoestrogens and steroid estrogens. The method enables the determination of targets at concentrations of lower nanogram-per-gram in sediments. The method has been successfully applied to the sediments collected from Pearl River Estuary (PRE), South China Sea, China. Nonylphenol and bisphenol-A (BPA) were detected in the range from 204.2 to 664.5 ng/g and 0.6 to 4.0 ng/g, respectively. None of the estrogens were found in the sediment samples.
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China. pengx@gig.ac.cn
Xianzhi
X
Peng
Zhendi
Z
Wang
Chun
C
Yang
Fanrong
F
Chen
Bixian
B
Mai
D001559:Benzhydryl Compounds; D002138:Calibration; D052244:Endocrine Disruptors / Q000032:analysis*; D004967:Estrogens / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D019015:Geologic Sediments / Q000737:chemistry*; D010636:Phenols / Q000032:analysis*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004967:Estrogens; D010636:Phenols; C025256:nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds