Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales).
Two new polyketides, actinofuranones A (1) and B (2), were isolated from the culture extract of a marine-derived Streptomyces strain designated CNQ766. The structures of 1 and 2 were elucidated by interpretation of NMR and other spectroscopic data and by chemical derivatization. The relative stereochemistries of these new molecules were assigned on the basis of analysis of NOE data and vicinal (1)H-(1)H coupling constants, while the absolute configurations of the asymmetric centers were determined using the modified Mosher's method.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, 92093-0204, USA.
Ji Young
JY
Cho
Hak Cheol
HC
Kwon
Philip G
PG
Williams
Christopher A
CA
Kauffman
Paul R
PR
Jensen
William
W
Fenical
D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006141:Guam; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
D005663:Furans; D018942:Macrolides; C510053:actinofuranone A; C510054:actinofuranone B