(+)-N-Deoxymilitarinone A, a neuritogenic pyridone alkaloid from the insect pathogenic fungus Paecilomyces farinosus.
A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 microM concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 microM.
Cheng
Yongxian
Y
Institute of Pharmacy, Friedrich-Schiller-University Jena, Germany.
Schneider
Bernd
B
Riese
Ulrike
U
Schubert
Barbara
B
Li
Zengzhi
Z
Hamburger
Matthias
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002681:China; D006801:Humans; D007915:Lepidoptera; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D016716:PC12 Cells; D010143:Paecilomyces / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
C509966:(+)-N-deoxymilitarinone A; D000470:Alkaloids; D009414:Nerve Growth Factors; D011728:Pyridones; C476668:militarinone B; C476670:militarinone D