Gene expression profiling: insights into skeletal muscle growth and development.
Microarray technology is now available for many livestock species, and animal scientists are beginning to utilize the technology to address issues of importance to animal agriculture. This review discusses how microarray technology has been applied to study global gene expression changes in skeletal muscle. For example, microarrays have been used to elucidate gene function in knockout mice, evaluate breed differences, evaluate the effects of hormone administration, and evaluate the effects of diet. Data generated from these global gene expression studies are providing new insights to stimulate future hypothesis-driven research.
Department of Animal Science, Iowa State University, Ames, 50011-3150, USA. jreecy@iastate.edu
J M
JM
Reecy
D Moody
DM
Spurlock
C H
CH
Stahl
D000824:Animal Nutritional Physiological Phenomena / Q000235:genetics; D000818:Animals; D000829:Animals, Domestic / Q000235:genetics / Q000502:physiology*; D020869:Gene Expression Profiling / Q000662:veterinary*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D005838:Genotype; D018482:Muscle, Skeletal / Q000254:growth & development*; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary