[Human herpesvirus 6 encephalitis in trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome].
BACKGROUND
Human herpesvirus 6 (HHV-6), the causative agent of the common exanthem subitum, is a known cause of central nervous system infection in immunocompromised patients. It has been suggested that HHV-6 participate in the development of drug-induced hypersensitivity syndrome.


METHODS
We reported a case of HHV-6 encephalitis associated with hypersensitivity syndrome induced by trimethoprim-sulfamethoxazole in a 72-year-old HIV-negative woman.


CONCLUSIONS
Our case confirmed that reactivation of HHV-6 infection may contribute to the development of the hypersensitivity syndrome.
Mohammedi
I
I
Service de réanimation médicale, Pavillon N, hôpital Edouard-Herriot, place d'Arsonval, 69003 Lyon, France. ismael.mohammedi@chu-lyon.fr
Mausservey
C
C
Hot
A
A
Najioullah
F
F
Kanitakis
J
J
Robert
D
D
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000998:Antiviral Agents / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D018792:Encephalitis, Viral / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D019349:Roseolovirus Infections / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D000998:Antiviral Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015774:Ganciclovir