Mapping out starvation responses.
What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 2006).
Department of Physiology and The UCSF Diabetes Center, University of California, San Francisco, Genentech Hall N-412C, San Francisco, California 94143, USA.
Kaveh
K
Ashrafi
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005247:Feeding Behavior; D044387:GTP-Binding Protein beta Subunits / Q000235:genetics / Q000502:physiology; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009154:Mutation; D010614:Pharynx / Q000187:drug effects / Q000201:enzymology; D011976:Receptors, Muscarinic / Q000502:physiology*; D013217:Starvation
D029742:Caenorhabditis elegans Proteins; D018679:Cholinergic Agonists; C427883:GPB-2 protein, C elegans; D044387:GTP-Binding Protein beta Subunits; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D001115:Arecoline; D020928:Mitogen-Activated Protein Kinases; D000109:Acetylcholine