[Tumor metastasis and MMP inhibitor].
Matrix metalloproteinase (MMP) plays important roles in tumor invasion and metastasis by degrading extracellular matrix components including collagen. Clinical trials of MMP inhibitor drugs have been carried out, however, they were not always as successful as expected.
Sato
Hiroshi
H
Kanazawa University, Cancer Research Institute.
D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases