Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases.
Central giant cell granuloma (CGCG) is a benign lesion of the jaws with a sometimes locally aggressive behaviour. The most common therapy is surgical curettage which has a high recurrence rate, especially in lesions with aggressive signs and symptoms (i.e. pain, paresthesia, root-resorption and rapid growth). Alternative therapies such as interferon alpha (INFalpha) or calcitonin are described in the literature. In this study 2 patients with an aggressive CGCG are presented who were treated with INF mono-therapy. INF mono-therapy was capable of terminating the rapid growth of the lesion in both patients and induced a partial reduction. Total resolution, however, was not obtained and alternative treatment is still necessary.
de Lange
J
J
Department of Oral and Maxillofacial Surgery, Academic Medical Center/Academic Center for Dentistry (ACTA), University of Amsterdam, The Netherlands. lotte.jan@wxs.nl
van den Akker
H P
HP
van den Berg
H
H
Richel
D J
DJ
Gortzak
R A Th
RA
D000293:Adolescent; D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002116:Calcitonin / Q000627:therapeutic use; D005260:Female; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008437:Maxilla / Q000000981:diagnostic imaging; D008439:Maxillary Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography; D012074:Remission Induction / Q000379:methods; D017211:Treatment Failure
D050071:Bone Density Conservation Agents; D016898:Interferon-alpha; C028815:salmon calcitonin; D002116:Calcitonin