Developmental potential of in vitro- and in vivo-matured human oocytes collected from stimulated and unstimulated ovaries.
The study by Li and coworkers demonstrated that human oocytes collected from the unstimulated ovary have high rates of meiotic spindle and chromosome abnormalities. Until improvements can be made to culture conditions, in vitro maturation protocols for patient treatment should be considered experimental.
Division of Endocrinology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63108, USA. lanzendorfs@wustl.edu
Susan E
SE
Lanzendorf
D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods*