Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats.
We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantly lower in ethanol treated rats. Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A:G ratio in serum. Ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.
Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim. manu_only@hotmail.com
M
M
Maneesh
H
H
Jayalekshmi
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy*; D007019:Hypoproteinemia / Q000139:chemically induced* / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D002492:Central Nervous System Depressants; D004151:Dipeptides; D008055:Lipids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D000431:Ethanol; D024502:alpha-Tocopherol; C002939:ornithylaspartate; D001205:Ascorbic Acid