Screening of Tanzanian medicinal plants for anti-Candida activity.
BACKGROUND
Candida albicans has become resistant to the already limited, toxic and expensive anti-Candida agents available in the market. These factors necessitate the search for new anti-fungal agents.


METHODS
Sixty-three plant extracts, from 56 Tanzanian plant species obtained through the literature and interviews with traditional healers, were evaluated for anti-Candida activity. Aqueous methanolic extracts were screened for anti-Candida activity by bioautography agar overlay method, using a standard strain of Candida albicans (ATCC 90028).


RESULTS
Twenty- seven (48%) out of the 56 plants were found to be active. Extracts of the root barks of Albizia anthelmintica and Balanites aegyptiaca, and roots of Plectranthus barbatus showed strong activity.


CONCLUSIONS
The extracts that showed strong anti-Candida activity are worth of further investigation in order to isolate and identify the active compounds.
Department of Pharmacognosy, School of Pharmacy, Muhimbili University College of Health Sciences P,O Box 65013, Dar Es Salaam, Tanzania.
Deborah K B
DK
Runyoro
Mecky I N
MI
Matee
Olipa D
OD
Ngassapa
Cosam C
CC
Joseph
Zakaria H
ZH
Mbwambo
D031289:Albizzia; D000935:Antifungal Agents / Q000494:pharmacology*; D032430:Balanites; D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots; D031346:Plectranthus; D013636:Tanzania
D000935:Antifungal Agents; D010936:Plant Extracts