[Myelotoxity of the nuclear enzyme inhibitors irinotecan and etoposide].
Irinotecan (campto) and etoposide cause the loss cells due to apoptosis, the early development of hypoplasia in bone marrow and lymphoid organs, and pancytopenia in peripheral blood upon single intravenous injection in maximum tolerated doses to white outbred rats. Etoposide causes more severe apoptosis and myelotoxicity than irinotecan. The changes are reversible within one to three months. On longer terms (from three to six months) after irinotecan and etoposide injection, there were a moderate decrease in the red blood cells and hematocrit, an increase of the MCV and MCHC indices, and premature thymus involution.
G V
GV
Karpova
E V
EV
Abramova
T I
TI
Fomina
Iu A
IuA
Shchemerova
T Iu
TIu
Dubskaia
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005047:Etoposide / Q000633:toxicity*; D000077146:Irinotecan; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D059003:Topoisomerase Inhibitors
D004791:Enzyme Inhibitors; D059003:Topoisomerase Inhibitors; D005047:Etoposide; D000077146:Irinotecan; D002166:Camptothecin