Diagnostics for TSE agents.
Bovine Spongiform Encephalopathy (BSE) is a fatal acquired neuro-degenerative disease in cattle, belonging to the group of transmissible spongiform encephalopathies (TSEs) or prion diseases. Since its first recognition in the U.K. in 1986, BSE has raised great public health concerns because the BSE agent has been shown to cause variant Creutzfeldt Jakob Disease (vCJD) in humans. With the introduction of mandatory active surveillance programmes in the European Union the need to develop rapid tests to diagnose BSE has become a high priority. Up to now, the European Union has approved twelve rapid tests for BSE monitoring in cattle, and approval for two new tests which have been evaluated in 2004 is pending. These rapid screening tests have been used in active surveillance of BSE and have greatly improved the detection of infected cattle before their entry into the human food chain. At present, no diagnostic test exists for the detection of prions in live animals or humans. New diagnostic techniques aimed at increasing the sensitivity and specificity of PrPsc detection in body fluids and at identifying novel surrogate markers are under development.
Raeber
A J
AJ
Prionics AG, Schlieren, Switzerland. alex.raeber@prionics.ch
Oesch
B
B
D000818:Animals; D000906:Antibodies / Q000032:analysis; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000517:prevention & control / Q000635:transmission; D004198:Disease Susceptibility; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology / Q000517:prevention & control; D005060:Europe; D006801:Humans; D018621:PrPC Proteins / Q000276:immunology; D017096:Prion Diseases / Q000517:prevention & control / Q000635:transmission*; D011328:Prions / Q000302:isolation & purification* / Q000472:pathogenicity
D000906:Antibodies; D018621:PrPC Proteins; D011328:Prions