[Effects of ionic and non-ionic roentgen-contrast media upon ex vivo hemostasis in rabbits].
The influence of ionic and non-ionic contrast media on the ex vivo hemostasis in rabbits was studied for ionic urografin (76 %), non-ionic ultravist-300, and non-ionic omnipaque-300 intravenously injected in medium and high doses (1.5 ml/kg and 3.0 ml/kg, respectively). Ionic urografin (1.5 ml/kg) almost did not influence the level of hemostasis ex vivo. Non-ionic contrast media (ultravist and omnipaque) in the medium diagnostic dose (1.5 ml/kg) activated the hemostasis, the effect being much more pronounced in the case of omnipaque. Dose-dependent action was observed for both ionic and non-ionic contrast media.
Klimanova
E V
EV
Petrukhina
G N
GN
Makarov
V A
VA
Sergeev
P V
PV
Bolotova
E N
EN
Shimanovskiĭ
N L
NL
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007472:Iohexol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008297:Male; D011817:Rabbits
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007472:Iohexol; C038192:iopromide