Distinct yet linked: chaperone networks in the eukaryotic cytosol.
The terms chaperone and heat-shock protein are frequently used as synonyms, but this is an oversimplification. Although one subset of chaperones is induced by heat stress, a distinct group fails to respond in the same manner. Recent work reveals that this latter group is linked to the translational apparatus and functions in co-translational processes.
Rospert
Sabine
S
Institute of Biochemistry and Molecular Biology, University of Freiburg, Hermann-Herder-Strasse 7, D-79104 Freiburg, Germany. sabine.rospert@biochemie.uni-freiburg.de
Chacinska
Agnieszka
A
D000818:Animals; D003600:Cytosol / Q000502:physiology; D006360:Heat-Shock Proteins / Q000235:genetics*; D008322:Mammals; D018832:Molecular Chaperones / Q000235:genetics*; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins