[Immunophenotypic features in leukemia of NK cell series].
The aim was to investigate the immunophenotypes of NK series leukemia. Immunophenotypes of 297 cases of acute leukemia (AL) were measured by flow cytometry, and these immucopenotypic features were analyzed. The results showed that 43 out of 297 cases of AL (14.5%) were CD56 positive. 6 cases were NK series leukemia and 37 cases were acute myelogenous leukemia with CD56 expressed. One patient has been diagnosed as myeloid/NK cell precursor acute leukemia, two patients were blastic NK cell leukemia, one was supposed to be NK-like T-cell lymphoma/leukemia, while another one was large granular lymphocyte leukemia (LGLL). It is concluded that almost all of CD56 positive leukemia were acute myelogenous leukemia with CD56 expressed. The immunophenotypes of NK series leukemia were antigens from hematopoietic stem cells to T/NK progenitor cells with meyloid antigen positive, and through NK progenitors to mature NK cells. The immunophenotypes of heterogeneous NK leukemia cells are different, that should be carefully distinguished.
Ma
Rou
R
Xiyuan Hospital, China Academy of TCM, Beijing 100091, China. xyxysys@yahoo.com.cn
Xu
Yong-Gang
YG
Yang
Xiao-Hong
XH
Hu
Xiao-Mei
XM
Li
Liu
L
Tang
Xu-Dong
XD
Zhang
Shan-Shan
SS
Xu
Shu
S
Wang
Hong-Zhi
HZ
Liu
Feng
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D019002:CD56 Antigen / Q000378:metabolism*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D016399:Lymphoma, T-Cell / Q000276:immunology; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
D019002:CD56 Antigen