[Regulation mechamion of mesenchymal stem cells to immunoeffector cells--review].
Mesenchymal stem cells have two main properties: self renewal and the ability to differentiate multiple lineage. Because MSCs exhibit low immunogenicity and demonstrate significant suppressive activity in cell cultures containing alloreactive T cells, they play an important role in transplantation immunology, but the exact mechanism remains unknown. This article focuses on the immunoregulatory feature of MSCs to immunoeffector cells, such as T cells, B cells, and NK cells. The role of MSC in transplantation immunoregulation, regulatory mechanism of MSC in cellular immunity (direct contact of cells with cells, apoptosis and immunoregulation of MSC on lymphocytes), immunoregulation of MSC on DC and NK cells were reviewed.
Department of Hemotology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Lin-Na
LN
Xie
D000818:Animals; D002450:Cell Communication; D049109:Cell Proliferation; D002478:Cells, Cultured; D018920:Coculture Techniques; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*