Prospective contributions of transgenic mouse models to central auditory research.
Neuroscientists are increasingly embracing mice as a means to address central nervous system questions at a molecular level. Examples abound from sensory systems like olfaction and vision. The use of mice to study central auditory processing, however, has remained relatively limited. In this commentary, I draw on some of the successes from other fields to highlight directions in which mouse models may contribute valuable and otherwise unattainable insights into the neural circuitry and plasticity within central auditory stations. Efforts towards this are beginning and would benefit from increased collaboration to generate useful transgenic mouse models for such studies.
Liu
Robert C
RC
Emory University Biology, Rollins Research Center, Rm 2131, 1510 Clifton Rd NE, Atlanta, GA 30322, USA. robert.liu@emory.edu
D000162:Acoustics; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D006309:Hearing / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic / Q000033:anatomy & histology / Q000502:physiology; D023421:Models, Animal; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000235:genetics