Increased expression of N-methyl-D-aspartate receptor subunit 2D in the skin of patients with fibromyalgia.
OBJECTIVE
We studied the expression of N-methyl-D-aspartate receptors (NMDAR) in skin of patients with fibromyalgia (FM) to investigate their role.


METHODS
The presence of NMDAR subtype 2B (NR2B) and subtype 2D (NR2D) was examined in skin tissues by immunohistochemistry and immunoblot. Skin tissues from 11 female patients with FM were examined and compared to those of 8 age- and sex-matched healthy controls.


RESULTS
NR2D expression was increased in the skin of patients with FM versus controls. There was no difference in the expression of NR2B between FM patients and controls.


CONCLUSIONS
The increased expression of NMDAR found in FM skin could be indicative of a more generalized increase in other peripheral nerves. This suggests that NR2D-selective antagonists may have implications in the treatment of allodynia in patients with FM.
Kim
Seong-Ho
SH
Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Gyeongbuk, Republic of Korea.
Jang
Tae Jung
TJ
Moon
Il Soo
IS
D015415:Biomarkers / Q000378:metabolism; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D009412:Nerve Fibers / Q000378:metabolism* / Q000473:pathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012867:Skin / Q000294:innervation / Q000378:metabolism* / Q000473:pathology
D015415:Biomarkers; D016194:Receptors, N-Methyl-D-Aspartate