[The inhibiting effect of a low-dose ionizing radiation on the primary humoral immunity in the early period of an postnatal ontogeny].
The single exposition of 3- and 4-week mice in a dose 0.1 Gy resulted in depressing primary T-dependent humoral immune response. Unlike juvenile ones at adult 16-week animals the stimulation antibody-formation took place. As a result of the administration of immunomodulating drugs, thymogene and nucleinate of a sodium in irradiation mice of 3-week age was an augmentation of the number of antibody-producing cells relatively in 2 and 4 times. At the same time at irradiated in dose 0.1 Gy of adult mice thymogene abrogated the stimulating effect of radiation. It is suggested that the probable cause of the immunosuppressing effect of a small dose of radiation can be an inactivation of a radiosensitive subpopulation of helper cells or selective stimulation of the functional activity of neonatal suppressor cells.
Sharetskiĭ
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AN
Abramova
M P
MP
D000375:Aging / Q000276:immunology / Q000528:radiation effects; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011839:Radiation, Ionizing; D013154:Spleen / Q000254:growth & development / Q000276:immunology / Q000528:radiation effects*; D013997:Time Factors