[Effect of nicotinamide on the reactions of peroxide oxidation of biomolecules in the rat brain and erythrocytes in 1,2-dichloroethane toxic injury].
It was established that acute poisoning of rats by 1,2-dichloroethane induced considerable changes in lipid peroxidation indices, glutathione content and activity of antioxidant enzymes--superoxidase, catalase, glutathione peroxidase in the brain tissue, erythrocytes and blood plasma. It was shown that nicotinamide in the dose of 200 mg/kg prevented considerable degree of the intoxication caused by 1,2-dichloroethane as well as activation of lipid peroxidation and inhibition of antioxidant defens enzyme activities in tissue of experimental animals.
Ianits'ka
L V
LV
Hubs'kyĭ
Iu I
IuI
Kuchmerovs'ka
T M
TM
Velykyĭ
M M
MM
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005025:Ethylene Dichlorides / Q000506:poisoning*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009536:Niacinamide / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D011041:Poisoning / Q000097:blood / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D014803:Vitamin B Complex / Q000494:pharmacology / Q000627:therapeutic use*
D001798:Blood Proteins; D005025:Ethylene Dichlorides; D014803:Vitamin B Complex; D009536:Niacinamide; C024565:ethylene dichloride