Sequential Pd- and Rh-catalyzed three-component cyclization with allenylboronate platform.
[reaction: see text] A novel three-component cyclization using allenylboronate ester is described. A three-component assembly of allenylboronate ester, aryl iodides, and stabilized carbon nucleophiles took place in the presence of palladium catalyst, furnishing functionalized alkenylboronate esters with high regio- and stereoselectivity. A Rh-catalyzed cyclization of the resultant three-component products then afforded interesting carbocyclic frameworks efficiently.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Keisuke
K
Tonogaki
Kenichiro
K
Itami
Jun-Ichi
J
Yoshida