Proapoptotic effect of Uncaria tomentosa extracts.
Uncaria tomentosa ("Uña de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, mutagenic and anti-mutagenic properties of extracts of the plant. The present study investigates the possible proapoptotic mechanism via the activation of caspase3, in cytostatic effects of root bark extracts of Uncaria tomentosa on three different tumoral cell lines.
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno Via Ponte don Melillo, Fisciano (Salerno), Italy.
Laura
L
De Martino
José Luis Silva
JL
Martinot
Silvia
S
Franceschelli
Arturo
A
Leone
Cosimo
C
Pizza
Vincenzo
V
De Feo
D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D004789:Enzyme Activation; D005434:Flow Cytometry; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D032070:Uncaria / Q000737:chemistry*
D010936:Plant Extracts; D053148:Caspase 3