Tropane aromatic ester alkaloids from a large-scale re-collection of Erythroxylum pervillei stem bark obtained in Madagascar.
Fractionation by pH zone-refining countercurrent chromatography of an extract of the stem bark of Erythroxylum pervillei, obtained on a kilogram scale in southern Madagascar, led to the isolation and characterization of four tropane aromatic ester alkaloids as minor constituents, namely, pervilleines G (5) and H (6) and cis-pervilleines B (7) and F (8). Their structures were determined by spectroscopic data interpretation.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, 43210, USA.
Young-Won
YW
Chin
William P
WP
Jones
Timothy J
TJ
Waybright
Thomas G
TG
McCloud
Philippe
P
Rasoanaivo
Gordon M
GM
Cragg
John M
JM
Cassady
A Douglas
AD
Kinghorn
D030921:Erythroxylaceae / Q000737:chemistry*; D006801:Humans; D008270:Madagascar; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014326:Tropanes / Q000737:chemistry* / Q000302:isolation & purification*
D014326:Tropanes; C467799:pervilleine B; C510041:pervilleine G; C510042:pervilleine H