A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research.
Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma), and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA "Asthma Research Strategy" document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of "susceptibility factors" that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction.
Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. Karin_Yeatts@unc.edu
Karin
K
Yeatts
Peter
P
Sly
Stephanie
S
Shore
Scott
S
Weiss
Fernando
F
Martinez
Andrew
A
Geller
Philip
P
Bromberg
Paul
P
Enright
Hillel
H
Koren
David
D
Weissman
MaryJane
M
Selgrade
D001249:Asthma / Q000150:complications / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D004198:Disease Susceptibility; D004781:Environmental Exposure; D006801:Humans; D006920:Hygiene; D015994:Incidence; D008019:Life Style; D009765:Obesity / Q000150:complications; D009784:Occupational Diseases