Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11.
Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor replication fitness or is mediated by efficient immune-mediated control, 5 macaques were inoculated intravenously with SIVmac1A11. Three animals that were depleted of CD8+ cells at the start of infection had more prolonged viremia with peak virus levels 1 to 2 logs higher than those of 2 animals that received a non-depleting control antibody. Thus, CD8+ cell-mediated immune responses play an important role in controlling SIVmac1A11 replication during acute viremia.
California National Primate Research Center, University of California, Davis, California, USA. kkvanrompay@ucdavis.edu
Koen K A
KK
Van Rompay
Emily J
EJ
Blackwood
Gary
G
Landucci
Don
D
Forthal
Marta L
ML
Marthas
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D016898:Interferon-alpha / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D007694:Killer Cells, Natural / Q000502:physiology; D008251:Macaca; D012367:RNA, Viral / Q000097:blood; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014766:Viremia / Q000276:immunology; D014779:Virus Replication
D016898:Interferon-alpha; D012367:RNA, Viral; D018664:Interleukin-12