Pneumocystis jirovecii genotypes and granulomatous pneumocystosis.
This study describes the initial data concerning molecular typing of Pneumocystis jirovecii in a patient having developed granulomatous Pneumocystis pneumonia (PCP). Three types, B(1)a(3), B(1)a(4), B(1)b(2), were identified. All three had been described in reports concerning patients with common diffuse alveolar PCP. The present data show that identical microorganisms can be involved in both granulomatous PCP and diffuse alveolar PCP and that the pathogenesis of the granulomatous response to P. jirovecii may more likely be related to host factors.
Service de Parasitologie et Mycologie Médicale, Centre Hospitalier Universitaire, Hôpital sud, 1, avenue René-Laennec, 80054 Amiens, France.
A
A
Totet
H
H
Duwat
G
G
Daste
A
A
Berry
R
R
Escamilla
G
G
Nevez
D015373:Bacterial Typing Techniques; D017809:Fatal Outcome; D005798:Genes, Bacterial; D005838:Genotype; D006099:Granuloma / Q000150:complications / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000145:classification / Q000150:complications / Q000382:microbiology* / Q000473:pathology