[Concentrational changes of mannose-binding proteins in blood plasma during noncomplicated pregnancy and in blood plasma of pregnant women with some infections].
Value of mannose-binding proteins was determined in plasma of pregnant women with no complications and also in pregnant women with some infections using affinitive chromatography. It was found that the concentration of mannose-binding proteins in blood plasma of women equals 0.152+/-0.025 mg/ml. The concentration of mannose-binding proteins in blood plasma increase during the consecutive trimesters of noncomplicated pregnancy. In the first trimester it equals 0.198+/-0.032 mg/ml, in the second 0.257+/-0.027 mg/ml and in the third trimester 0.345+/-0.034 mg/ml. We also found that the concentration of mannose-binding proteins in blood plasma of pregnant woman suffering with chlamydial infection equals 1.025+/-0.115 mg/ml, and in blood plasma of pregnant woman suffering with cytomegalovirus infection 1.278+/-0.144 mg/ml. The obtained data confirm a hypothesis of increased activity of innate immune system during pregnancy. Also according to this results complications accompanied by chlamydial and cytomegalovirus infections during pregnancy is the result of increasing activity of mannose-binding proteins.
Khotivari
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Mikeladze
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DG
D000328:Adult; D002690:Chlamydia Infections / Q000097:blood* / Q000382:microbiology*; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000382:microbiology*; D005260:Female; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000382:microbiology; D014621:Vagina / Q000382:microbiology*
D037601:Mannose-Binding Lectin