[Gynaecological and obstetrical aspects of recurrent urinary tract infections].
The microbial colonization of vulva, vagina and cervix uteri represents the reservoir for recurrent urinary tract infection. All bacterial species of normal cutaneous or gastrointestinal flora can be found in the external genital tract even under physiological conditions. The higher concentration of microbes adds to the predisposition for urinary tract infection in cases of dysbiosis or inflammation, apart from specific infection by Trichomonas vaginalis, Neisseria gonorrhoeae or Chlamydia trachomatis. The specific immunological interaction between bacteria and host, i.e. between virulence factors and intrinsic defense, appears to be the major mechanism paving the way for recurrent infection. The elimination of predisposing factors is the clue for successful therapy as well as for prevention of recurrence.
Klinik für Frauenheilkunde und Geburtshilfe, Helios-Klinkum, Nordhäuser Strasse 74, 99089 Erfurt. uhoyme@erfurt.helios-kliniken.de
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D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000378:metabolism; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D001437:Bacteriuria / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D012008:Recurrence; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
D000892:Anti-Infective Agents, Urinary; D000907:Antibodies, Bacterial