Acute effects of environmental tobacco smoke and dried dung smoke on lung histopathology in rabbits.
OBJECTIVE
To compare the effects of cigarette smoke and dried dung smoke exposure on the histopathology of lungs.


METHODS
Three groups each with five rabbits were formed. The cigarette smoke group was exposed to cigarette smoke, the biomass group was exposed to dried dung smoke and the control group was exposed to dry air 1 hour daily for 1 month. At the end of 1 month, animals were sacrificed and lung tissues were examined histopathologically.


RESULTS
Histopathological evaluation of rabbits' lungs revealed that intraparenchymal vascular congestion and thrombosis, intraparenchymal haemorrhage, respiratory epithelial proliferation, number of macrophages in the alveolar and bronchial lumen, alveolar destruction, emphysematous changes and bronchoalveolar haemorrhage scores were significantly increased in rabbits exposed to cigarette smoke compared with the control group. Respiratory epithelial proliferation, alveoli destruction and emphysematous change scores were significantly increased in rabbits exposed to dried dung smoke compared with the control group.


CONCLUSIONS
Although less than the effects of cigarette smoke, dried dung smoke had severe histopathological effects on rabbits' lungs.
Fidan
Fatma
F
Afyon Kocatepe University Faculty of Medicine, Department of Pulmonary Medicine, Turkey. drffidan@yahoo.com
Unlu
Mehmet
M
Sezer
Murat
M
Sahin
Onder
O
Tokyol
Cigdem
C
Esme
Hidir
H
D000393:Air Pollutants / Q000009:adverse effects*; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000818:Animals; D005243:Feces; D006470:Hemorrhage / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D011656:Pulmonary Emphysema / Q000473:pathology; D011817:Rabbits; D020545:Respiratory Mucosa / Q000473:pathology; D012906:Smoke / Q000009:adverse effects*; D015208:Smoke Inhalation Injury / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D000393:Air Pollutants; D012906:Smoke; D014028:Tobacco Smoke Pollution