Familial aggregation of sinonasal polyps correlates with severity of disease.
OBJECTIVE
Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP.


METHODS
A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance).


RESULTS
Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs.


CONCLUSIONS
Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity.


METHODS
B-2b.
Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA. cohenn@uphs.upenn.edu
Noam A
NA
Cohen
Jeffrey S
JS
Widelitz
Alexander G
AG
Chiu
James N
JN
Palmer
David W
DW
Kennedy
D015982:Bias; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D009298:Nasal Polyps / Q000453:epidemiology* / Q000235:genetics; D010254:Paranasal Sinus Diseases / Q000453:epidemiology* / Q000235:genetics; D011127:Polyps / Q000453:epidemiology / Q000235:genetics; D012720:Severity of Illness Index; D017678:Sex Distribution; D011795:Surveys and Questionnaires