The serotonin syndrome complicating co-prescription of paroxetine and clarithromycin.
Caritas St. Elizabeth's Medical Center, Boston, Massachusetts, USA.
Bertrand L
BL
Jaber
Luis F
LF
Lobon
Nicolaos E
NE
Madias
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects; D001007:Anxiety / Q000188:drug therapy; D017291:Clarithromycin / Q000008:administration & dosage / Q000009:adverse effects*; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004347:Drug Interactions; D011307:Drug Prescriptions; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000008:administration & dosage / Q000009:adverse effects*; D012141:Respiratory Tract Infections / Q000188:drug therapy; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D018687:Antidepressive Agents, Second-Generation; D017291:Clarithromycin; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; C104464:CYP3A protein, human