Functional organisation and gain of activity: the case of the antibacterial tetra-para-guanidinoethyl-calix[4]arene.
The antibacterial activities of the para-guanidinoethylphenol and of its cyclic tetramer, the tetra-para-guanidinoethyl-calix[4]arene, have been evaluated on reference gram-positive and gram-negative bacteria. Antibiotic disk diffusion assays completed by micromethod technique were employed to determine if a synergistic effect could be expected from the spatial organisation of the monomer into its cyclic tetrameric analogue. Disk diffusion assays and microdilution experiments revealed better properties for the calixarene species, with a real and important gain of activity with regards to the monomer.
Unité Mixte de Recherche UHP-CNRS 7565, Université Henri Poincaré, Nancy1 Groupe d'Etude des Vecteurs Supramoléculaires du Médicament, Faculté de Pharmacie, 5, rue Albert Lebrun, BP 80403, 54001 Nancy Cedex, France.
Maxime
M
Mourer
Raphaël E
RE
Duval
Chantal
C
Finance
Jean-Bernard
JB
Regnouf-de-Vains
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004058:Diffusion; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation
D000900:Anti-Bacterial Agents; D006146:Guanidines; C512158:tetra-para-guanidinoethyl-calix(4)arene