Aromatic borylation/amidation/oxidation: a rapid route to 5-substituted 3-amidophenols.
[reaction: see text] 5-Substituted 3-amidophenols are prepared by subjecting 3-substituted halobenzenes to an Ir-catalyzed aromatic borylation, followed by a Pd-catalyzed amidation, and finally an oxidation of the boronic ester intermediate. The entire C-H activation borylation/amidation/oxidation sequence can be accomplished without isolation of any intermediate arenes. Usefully, amide partners can include lactams, carbamates, and ureas.
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Feng
F
Shi
Milton R
MR
Smith
Robert E
RE
Maleczka