Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs.
The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. Plasma levels of myoglobin and troponin I were quantified during reperfusion. Vehicle or cariporide (2.5 mg/kg) were administered i.v. before ischaemia and infused throughout ischaemia and for the beginning of reperfusion. In vehicle-treated pigs, the infarct size represented 26% +/- 3% of the area at risk. Cariporide significantly decreased the infarct size by 66% +/- 9%, and significantly reduced plasma levels of myoglobin and troponin I. A strongly correlated linear relationship between myocardial necrosis and plasma levels of myoglobin (R = 0.966, P < 0.0001) or troponin I (R = 0.855, P < 0.0001) was clearly identified. In conclusion, in our porcine model of myocardial infarction, even with small infarcts (in the presence of cariporide), plasma levels of myoglobin and troponin I are predictive of the presence of necrosis and its extent.
Centre de Recherche Pierre Fabre, 17 Av. Jean Moulin, 81106 Castres, France. robert.letienne@pierre-fabre.com
Robert
R
Létienne
Lydia
L
Bel
Anne-Marie
AM
Bessac
Delphine
D
Denais
Anne-Dominique
AD
Degryse
Gareth W
GW
John
Bruno
B
Le Grand
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D015425:Myocardial Reperfusion; D009211:Myoglobin / Q000097:blood*; D013450:Sulfones / Q000627:therapeutic use*; D013552:Swine; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D002316:Cardiotonic Agents; D006146:Guanidines; D009211:Myoglobin; D013450:Sulfones; D019210:Troponin I; C093373:cariporide