[Lack of antidepresant-like activity of some ligands of polyamine binding sites of NMDA receptors in models of depression].
Arcain and a series of the partial modulators of polyamine binding sites of NMDA receptors (spermine- and adamantyl-containing polyamines IEM-1460, IEM-1490, IEM-1592, IEM-1755) do not display (in contrast to melipramine and memantine) antidepressant-like action in the forced swimming test and reserpine-induced depression test in rats. Compounds IEM-1460, IEM-1490, IEM-1592 increase the total time of immobilization in the Porsolt test, probably, by facilitating the development of stress-induced depression. It is supposed that the prodepressant activity of these compounds is mediated by NMDA-receptors having NR1/NR2C and NR1/NR2D subunit composition.
Zin'kovskaia
L Ia
LIa
Kidin
Iu V
IuV
Komissarov
I V
IV
Obraztsova
O G
OG
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001667:Binding, Competitive; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008024:Ligands; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D000928:Antidepressive Agents; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D011073:Polyamines; D016194:Receptors, N-Methyl-D-Aspartate