Antifungal Activity of Chromolaena odorata (L.) King & Robinson(Asteraceae) of Cameroon.
An aqueous ethanol extract of leaves of Chromolaena odorata and some of its fractions were examined for their antifungal properties by dilution methods on solid and liquid media, using yeasts and filamentous fungi. Extract and fractions inhibit the in vitro growth of Cryptococcus neoformans, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with a minimal inhibitory concentration range from 62.5 to 500 microg/ml for the extract and from 25 to 100 microg/ml for fractions. A qualitative chemical analysis of the extract and fractions showed the presence of biologically active constituents such as some coumarins, flavonoids, phenols, tannins and sterols. No toxic effect was observed in mice treated per os with the extract. This study provides a scientific confirmation of the use of Chromolaena odorata in traditional medicine.
Ngono Ngane
A
A
Laboratoire de Biochimie, Faculté des Sciences, Douala, Cameroun. angono@yahoo.com
Ebelle Etame
R
R
Ndifor
F
F
Biyiti
L
L
Amvam Zollo
P H
PH
Bouchet
P
P
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002163:Cameroon; D036604:Chromolaena / Q000737:chemistry*; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D023382:Toxicity Tests, Acute
D000935:Antifungal Agents; D010936:Plant Extracts