Alveolar cleft osteoplasty using tissue-engineered osteogenic material.
The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.
Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan. hibihi@med.nagoya-u.ac.jp
H
H
Hibi
Y
Y
Yamada
M
M
Ueda
Y
Y
Endo
D000539:Alveolar Process / Q000002:abnormalities*; D000543:Alveoloplasty / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D008437:Maxilla / Q000002:abnormalities* / Q000601:surgery; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D010012:Osteogenesis / Q000502:physiology; D017713:Platelet Transfusion; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed