Successful organ transplantation from donors with Acinetobacter baumannii septic shock.
Donor bacteremia with severe sepsis, especially due to gram-negative organisms, has been considered a contraindication to transplantation. Over a 6-month period we prospectively collected standardized data on all brain-dead, heart-beating organ donors with gram negative bacteremia and septic shock and the recipients of their organs in hospitals throughout Israel. Donors were treated with appropriate antibiotics for at least 48 hr prior to organ retrieval while recipients received 7 days of culture-specific antibiotics following transplantation. In total, 12 organs were transplanted (5 kidneys, 2 livers, 3 lungs and 2 hearts) from 3 donors with Acinetobacter baumannii bacteremia and septic shock. All patients were alive with good graft function 60 days following transplantation, apart from one of the heart recipients who died of primary nonfunction on the second postoperative day. Two recipients developed postoperative infections, none with Acinetobacter sp. (one Pseudomonas sp. urinary tract infection, one Klebsiella sp. central venous catheter sepsis).
Cohen
Jonathan
J
Department of General Intensive Care, Rabin Medical Center, Campus Beilinson, Petah Tikva 49100, Israel. cohenjon@post.tau.ac.il
Michowiz
Rachael
R
Ashkenazi
Tamar
T
Pitlik
Silvio
S
Singer
Pierre
P
D000151:Acinetobacter Infections; D040981:Acinetobacter baumannii; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D011446:Prospective Studies; D012772:Shock, Septic; D014019:Tissue Donors
D000900:Anti-Bacterial Agents