Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia.
Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.
Geriatric Department, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing.
Jinzhou
J
Tian
Junxiang
J
Yin
Huan
H
Liu
Chengzi
C
Yang
Yongyan
Y
Wang
D000368:Aged; D000369:Aged, 80 and over; D015161:Dementia, Multi-Infarct / Q000188:drug therapy* / Q000523:psychology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000523:psychology; D008875:Middle Aged; D014706:Verbal Learning
D004365:Drugs, Chinese Herbal