Gatifloxacin resistance and mutations in gyra after unsuccessful Helicobacter pylori eradication in Japan.
A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 microg/ml and mutations of the gyrA gene of H. pylori was demonstrated.
Department of Internal Medicine, Keio University School of Medicine, and Department of Gastroenterology, Kitasato Institute Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Toshihiro
T
Nishizawa
Hidekazu
H
Suzuki
Kumiko
K
Kurabayashi
Tatsuhiro
T
Masaoka
Hiroe
H
Muraoka
Mikiji
M
Mori
Eisuke
E
Iwasaki
Intetsu
I
Kobayashi
Toshifumi
T
Hibi
D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027081:DNA Gyrase; D000077734:Gatifloxacin