Telomeric silencing of an open reading frame in Saccharomyces cerevisiae.
The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.
Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA.
Arnold B
AB
Barton
David B
DB
Kaback
D001483:Base Sequence; D015825:Chromosomes, Fungal / Q000235:genetics*; D004271:DNA, Fungal / Q000235:genetics; D020868:Gene Silencing; D005800:Genes, Fungal; D009154:Mutation; D016366:Open Reading Frames; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics; D016615:Telomere / Q000235:genetics*
D004271:DNA, Fungal; C084122:SIR3 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae