CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion.
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections.
Aichele
Peter
P
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany. peter.aichele@uniklinik-freiburg.de
Unsoeld
Heike
H
Koschella
Marie
M
Schweier
Oliver
O
Kalinke
Ulrich
U
Vucikuja
Smiljka
S
D019264:Adoptive Transfer; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D049109:Cell Proliferation; D006023:Glycoproteins / Q000276:immunology; D008213:Lymphocyte Activation; D008216:Lymphocytic Choriomeningitis / Q000276:immunology / Q000473:pathology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000276:immunology; D017471:Receptors, Interferon / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology; D000096743:Interferon gamma Receptor
D000956:Antigens, Viral; D006023:Glycoproteins; D010446:Peptide Fragments; D017471:Receptors, Interferon; D014764:Viral Proteins; D000096743:Interferon gamma Receptor; C094244:glycoprotein peptide 33-41, Lymphocytic choriomeningitis virus