The stationary distribution of allele frequencies when selection acts at unlinked loci.
We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.
Department of Mathematics and Statistics, Lancaster University, Lancaster LA1 4YF, UK. p.fearnhead@lancs.ac.uk
Paul
P
Fearnhead
D000704:Analysis of Variance; D005787:Gene Frequency / Q000235:genetics*; D040961:Genetic Drift; D008040:Genetic Linkage / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D011157:Population Dynamics; D012641:Selection, Genetic; D013997:Time Factors