Effect of a rapid intra-arterial infusion of dextrose 5% prior to coronary angiography on frequency of contrast-induced nephropathy in high-risk patients.
Contrast-induced nephropathy (CIN) is a common complication of coronary angiography that is associated with significant morbidity and mortality. Preexisting renal dysfunction is the most important risk factor for the development of CIN. A novel strategy of infusing 1 L of 5% dextrose immediately before catheterization is associated with a lower rate of CIN in those at high risk (creatinine clearance < or = 60 ml/min). CIN occurred in 47 patients (5.7%) in the control group and 2 patients (1.4%) in the group treated with 5% dextrose. The relative risk decrease was 73% (p = 0.03). This is an effective, quick, and inexpensive method of improving outcomes in patients who undergo percutaneous coronary interventions.
The Division of Cardiology, Washington Hospital Center, Washington, DC, USA.
Leonardo C
LC
Clavijo
Tina L
TL
Pinto
Pramod K
PK
Kuchulakanti
Rebecca
R
Torguson
William W
WW
Chu
Lowell F
LF
Satler
Kenneth M
KM
Kent
William O
WO
Suddath
Ron
R
Waksman
Augusto D
AD
Pichard
D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000652:urine; D004334:Drug Administration Schedule; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control* / Q000652:urine; D008297:Male; D011300:Preoperative Care; D015532:Rehydration Solutions / Q000008:administration & dosage*; D012307:Risk Factors; D016896:Treatment Outcome
D003287:Contrast Media; D015532:Rehydration Solutions; D003404:Creatinine; D005947:Glucose