Dense-core secretory granule biogenesis.
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.
Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Taeyoon
T
Kim
Marjorie C
MC
Gondré-Lewis
Irina
I
Arnaoutova
Y Peng
YP
Loh
D000818:Animals; D002784:Cholesterol / Q000502:physiology; D002864:Chromogranins / Q000502:physiology; D004703:Endocrine System / Q000378:metabolism; D006056:Golgi Apparatus / Q000502:physiology; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D022142:Secretory Vesicles / Q000737:chemistry* / Q000502:physiology*
D002864:Chromogranins; D006728:Hormones; D008055:Lipids; D009479:Neuropeptides; D002784:Cholesterol