Proapoptotic effect of Uncaria tomentosa extracts.
Uncaria tomentosa ("Uña de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, mutagenic and anti-mutagenic properties of extracts of the plant. The present study investigates the possible proapoptotic mechanism via the activation of caspase3, in cytostatic effects of root bark extracts of Uncaria tomentosa on three different tumoral cell lines.
De Martino
Laura
L
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno Via Ponte don Melillo, Fisciano (Salerno), Italy.
Martinot
José Luis Silva
JL
Franceschelli
Silvia
S
Leone
Arturo
A
Pizza
Cosimo
C
De Feo
Vincenzo
V
D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D004789:Enzyme Activation; D005434:Flow Cytometry; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D032070:Uncaria / Q000737:chemistry*
D010936:Plant Extracts; D053148:Caspase 3