Assembling the bacterial segrosome.
Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation.
Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK. finbarr.hayes@manchester.ac.uk
Finbarr
F
Hayes
Daniela
D
Barillà
D002503:Centromere; D020090:Chromosome Segregation; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial; D005544:Forecasting; D005798:Genes, Bacterial; D008957:Models, Genetic; D009698:Nucleoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010957:Plasmids
D004269:DNA, Bacterial; D009698:Nucleoproteins