The high-affinity IgE receptor (FcepsilonRI): a critical regulator of airway smooth muscle cells?
The airway smooth muscle (ASM) has been typically described as a contractile tissue, responding to neurotransmitters and inflammatory mediators. However, it has recently been recognized that ASM cells can also secrete cytokines and chemokines and express cell adhesion molecules that are important for the perpetuation and modulation of airway inflammation. Recent progress has revealed the importance of IgE Fc receptors in stimulating and modulating the function of these cells. In particular, the high-affinity receptor for IgE (FcepsilonRI) has been identified in primary human ASM cells in vitro and in vivo within bronchial biopsies of atopic asthmatic individuals. Moreover, activation of this receptor has been found to induce marked increases in the intracellular calcium concentrations and T helper 2 cytokines and chemokines release. This and other evidence discussed in this review provide an emerging view of FcepsilonR/IgE network as a critical modulator of ASM cell function in allergic asthma.
Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. gounni@cc.umanitoba.ca
Abdelilah Soussi
AS
Gounni
D001249:Asthma / Q000378:metabolism*; D001980:Bronchi / Q000166:cytology / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D018448:Models, Immunological; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017455:Receptors, IgE / Q000502:physiology*; D015398:Signal Transduction
D018925:Chemokines; D016207:Cytokines; D017455:Receptors, IgE; D002118:Calcium