[Effect of tryptophan on mediator content in the brain tissue of rats with different levels of seizure susceptibility].
The effects of per orally administered tryptophan on serotonin and GABA levels in different brain areas were found to depend on initial levels of seizure susceptibility. Elimination of difference in the content of investigated mediator between animals with high and low seizure susceptibility was observed. Serotonin level was approximated to the initial one in rats with high seizure susceptibility but GABA level was approximated to the initial one in rats with low seizure susceptibility. Possible mechanismes of realization of tryptophan therapeutic effects are discussed.
Popova
L D
LD
D000161:Acoustic Stimulation; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004198:Disease Susceptibility; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D014364:Tryptophan