[Identification strategy of RHCE gene variants at the National Blood Group Reference Laboratory: impact on transfusion safety].
The RH blood group is the most polymorphic and immunogenic blood group system. The RH locus is composed of 2 highly homologous genes: the RHD gene encoding the D polypeptide; and the RHCE gene, encoding C or c together with either E or e polypeptides. Numerous variants exist for both RHD and RHCE genes. Among them we were interested in the serological and molecular definition of numerous pre-published RHCE variants encountered in different populations. The identification of these variants is crucial to ensure the transfusion safety for patients expressing these variants. Here we propose a procedure to identify some of them and discuss the adequate transfusion strategy. This procedure has enable us to identify new variants to be presented at the symposium.
Centre national de référence pour les groupes sanguins (CNRGS), institut national de la transfusion sanguine, 20, rue Bouvier, BP 79, 75522 Paris cedex 11, France. hansart@ints.fr
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Ansart-Pirenne
D001787:Blood Group Incompatibility / Q000517:prevention & control; D001788:Blood Grouping and Crossmatching / Q000379:methods* / Q000592:standards; D005006:Ethnicity / Q000235:genetics; D005602:France; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007518:Isoantibodies / Q000032:analysis / Q000097:blood; D008958:Models, Molecular; D012204:Rh-Hr Blood-Group System / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000276:immunology; D018029:Rho(D) Immune Globulin; D065227:Transfusion Reaction
D007518:Isoantibodies; C066468:RHCE protein, human; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; C026410:Rho(D) antigen