Metabolic syndrome as a risk factor for contrast-induced nephropathy in non-diabetic elderly patients with renal impairment.
OBJECTIVE
Metabolic syndrome (MS) as a risk factor for contrast-induced nephropathy (CIN) has not been studied. The aim of the present study was to assess the influence of MS on the development of CIN in patients undergoing coronary angiography.


METHODS
This was a prospective cohort study. A total of 219 non-diabetic patients with reduced kidney function and age >or=60 years were divided into two groups (MS, n = 107 and non-MS, n = 112). CIN was defined as an increase of >or=25% in creatinine over the baseline value within 48 h of angiography.


RESULTS
CIN occurred in 14% of the MS group and 3.6% of the non-MS group (p = 0.006). Serum creatinine increased from 1.06 +/- 0.17 to 1.12 +/- 0.27 mg/dl in the MS group and from 1.03 +/- 0.17 to 1.09 +/- 0.23 mg/dl in the non-MS group (p < 0.001). MS was a risk indicator of CIN [odds ratio (OR) 4.26; 95% confidence interval (95% CI) 1.19-15.25; p = 0.026). Impaired fasting glucose (OR 4.72; 95% CI 1.53-14.56; p = 0.007), high triglyceride (OR 4.06; 95% CI 1.22-13.44; p = 0.022), and multivessel involvement (OR 3.14; 95% CI 1.07-9.82; p = 0.038) in the MS group were predictors of CIN.


CONCLUSIONS
Our data support the hypothesis that patients with MS are at risk of developing CIN.
Department of Nephrology, Ataturk Training and Research Hospital, Izmir, Turkey. info@omertoprak.com
Omer
O
Toprak
Mustafa
M
Cirit
Murat
M
Yesil
Daniel W
DW
Byrne
Nursen
N
Postaci
Serdar
S
Bayata
Karen M
KM
Majchrzak
Ertap
E
Esi
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology; D007677:Kidney Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D003287:Contrast Media; D014280:Triglycerides