Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.
BACKGROUND
Little is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression. Accelerated telomere shortening may reflect stress-related oxidative damage to cells and accelerated aging, and severe psychosocial stress has been linked to telomere shortening. We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging.


METHODS
Telomere length was measured by Southern Analysis in 44 individuals with chronic mood disorders and 44 nonpsychiatrically ill age-matched control subjects.


RESULTS
Telomere length was significantly shorter in those with mood disorders, representing as much as 10 years of accelerated aging.


CONCLUSIONS
These results provide preliminary evidence that mood disorders are associated with accelerated aging and may suggest a novel mechanism for mood disorder-associated morbidity and mortality.
Simon
Naomi M
NM
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. NSIMON@Partners.org
Smoller
Jordan W
JW
McNamara
Kate L
KL
Maser
Richard S
RS
Zalta
Alyson K
AK
Pollack
Mark H
MH
Nierenberg
Andrew A
AA
Fava
Maurizio
M
Wong
Kwok-Kin
KK
D000328:Adult; D000375:Aging / Q000235:genetics*; D001007:Anxiety / Q000150:complications / Q000235:genetics; D001714:Bipolar Disorder / Q000150:complications / Q000235:genetics; D016022:Case-Control Studies; D016922:Cellular Senescence / Q000235:genetics; D019457:Chromosome Breakage; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D008957:Models, Genetic; D019964:Mood Disorders / Q000150:complications / Q000235:genetics*; D012016:Reference Values; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000209:etiology / Q000235:genetics*; D016615:Telomere