sorLA: sorting out APP.
The accumulation of amyloid-beta peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-beta peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.
Center for Basic Neuroscience and Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Shah@UTSouthwestern.edu
Sanjiv
S
Shah
Gang
G
Yu
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000235:genetics* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000235:genetics*; D006801:Humans; D026502:LDL-Receptor Related Proteins; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D053764:Presenilin-1; D011973:Receptors, LDL / Q000235:genetics*
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D026502:LDL-Receptor Related Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D011973:Receptors, LDL; C102582:SORL1 protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse