The KEOPS complex: a rosetta stone for telomere regulation?
The detailed mechanisms underlying telomere capping and its relationship to telomerase activity are still unclear, although many proteins have been implicated in either or both processes. In this issue of Cell, the surprising identification of a new complex, called KEOPS, which promotes both telomere uncapping and elongation is presented.
Department of Molecular Biology and NCCR Program "Frontiers in Genetics," University of Geneva, Sciences III, 30, Quai Ernest-Ansermet, CH-1211, Geneva 4, Switzerland.
Alessandro
A
Bianchi
David
D
Shore
D015971:Gene Expression Regulation, Enzymologic; D046911:Macromolecular Substances / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
D046911:Macromolecular Substances; D019098:Telomerase