Management of unanticipated outcomes in transgenic mouse facilities.
Experimental manipulations of rodents may result in unexpected adverse phenotypes that present problems from both regulatory and animal care-veterinary perspectives. The authors discuss the implications of unanticipated outcomes and describe a cage card-based tracking system used at the Harvard Medical School for the early detection and handling of unanticipated phenotypes in genetically altered rodents.
Covance Research Products, Inc., Denver, PA 17517, USA. stacy.pritt@covance.com
Stacy
S
Pritt
Kerri
K
Cozine
Henry
H
Warren
D035661:Animal Care Committees / Q000331:legislation & jurisprudence; D000822:Animal Husbandry / Q000379:methods*; D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D003625:Data Collection / Q000379:methods; D004195:Disease Models, Animal; D006799:Housing, Animal; D007756:Laboratory Animal Science / Q000331:legislation & jurisprudence / Q000379:methods*; D051379:Mice; D008822:Mice, Transgenic; D014730:Veterinary Medicine / Q000379:methods* / Q000592:standards