Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.
We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
Heilier
Jean-François
JF
Industrial Toxicology and Occupational Medicine Unit, Université catholique de Louvain, Belgium. Jean-Francois.Heilier@toxi.ucl.ac.be
Donnez
Olivier
O
Van Kerckhove
Valérie
V
Lison
Dominique
D
Donnez
Jacques
J
D001141:Aromatase / Q000378:metabolism*; D004715:Endometriosis / Q000201:enzymology*; D005260:Female; D006801:Humans; D009928:Organ Specificity; D010049:Ovarian Diseases / Q000201:enzymology*; D010532:Peritoneal Diseases / Q000201:enzymology*; D012002:Rectal Diseases / Q000201:enzymology*; D014018:Tissue Distribution; D014623:Vaginal Diseases / Q000201:enzymology*
D001141:Aromatase