Design of highly enantioselective organocatalysts based on molecular recognition.
[reaction: see text] Various organocatalysts have been designed based on molecular recognition to catalyze the asymmetric direct aldol reaction of ketones with aryl and alkyl alpha-keto acids, affording beta-hydroxyl carboxylic acids with a tertiary stereogenic center with excellent enantioselectivities of up to 98% ee. A linear effect was observed for the reaction, demonstrating a single molecule of the catalyst involved in the catalysis.
Tang
Zhuo
Z
Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
Cun
Lin-Feng
LF
Cui
Xin
X
Mi
Ai-Qiao
AQ
Jiang
Yao-Zhong
YZ
Gong
Liu-Zhu
LZ