Blood compatible carbon nanotubes--nano-based neoproteoglycans.
Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
Saravanababu
S
Murugesan
Tae-Joon
TJ
Park
Hoichang
H
Yang
Shaker
S
Mousa
Robert J
RJ
Linhardt
D001672:Biocompatible Materials / Q000737:chemistry*; D001769:Blood / Q000378:metabolism*; D006493:Heparin / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010314:Partial Thromboplastin Time; D013916:Thrombelastography
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D006493:Heparin