In vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes.
Isonicotinoylhydrazide Schiff's bases formed by the reaction of substituted and unsubstituted furyl-2-carboxaldehyde and thiophene-2-carboxaldehyde with isoniazid and, their Co (II), Cu (II), Ni (II) and Zn (II) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysenteriae, Bacillus cereus, Corynebacterium diphtheriae, Staphylococcus aureus and Streptococcus pyogenes bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. The results of these studies show the metal complexes to be more antibacterial and antifungal against one or more bacterial/fungal strains as compared to the uncomplexed compounds. The brine shrimp bioassay indicated Schiff's bases, L3 and L6 and, their Cu (II) and Ni (II) metal complexes to be cytotoxic against Artemia salina, while all other compounds were inactive (LD50 > 1000).
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan. zchohan@mul.paknet.com.pk
Zahid H
ZH
Chohan
M
M
Arif
Zahid
Z
Shafiq
Muhammad
M
Yaqub
Claudiu T
CT
Supuran
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001156:Artemia; D003035:Cobalt / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D007538:Isoniazid / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects*; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry / Q000378:metabolism; D012545:Schiff Bases / Q000494:pharmacology*; D017741:Survivors; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; D007538:Isoniazid