Mapping out starvation responses.
What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 2006).
Ashrafi
Kaveh
K
Department of Physiology and The UCSF Diabetes Center, University of California, San Francisco, Genentech Hall N-412C, San Francisco, California 94143, USA.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005247:Feeding Behavior; D044387:GTP-Binding Protein beta Subunits / Q000235:genetics / Q000502:physiology; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009154:Mutation; D010614:Pharynx / Q000187:drug effects / Q000201:enzymology; D011976:Receptors, Muscarinic / Q000502:physiology*; D013217:Starvation
D029742:Caenorhabditis elegans Proteins; D018679:Cholinergic Agonists; C427883:GPB-2 protein, C elegans; D044387:GTP-Binding Protein beta Subunits; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D001115:Arecoline; D020928:Mitogen-Activated Protein Kinases; D000109:Acetylcholine