Scope and practicality of in vivo testing for adventitious agents.
An overview of the in vivo assays currently performed to test for the presence of adventitious contaminants is available. Retrospective validation data have been reviewed. Assay problems specifically related to the testing of vaccine viral stocks and cell substrates may be discussed.
Whiteman
M D
MD
BioReliance Corporation, Invitrogen Bioservices, Rockville, MD 20850, USA. mary.whiteman@invitrogen.com
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002642:Chick Embryo; D004340:Drug Contamination / Q000517:prevention & control*; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D015203:Reproducibility of Results; D014780:Viruses / Q000302:isolation & purification* / Q000472:pathogenicity*; D015017:Yolk Sac