"Burst and slow complexes" in nonconvulsive epileptic status.
Generalized 1Hz, burst-and-slow-wave complexes were observed in a comatosed patient with acute disseminated encephalomyelitis (ADEM) when she showed extremely intractable, generalized convulsions and fragmented myoclonus in the whole body. Two types of short-latency SEPs were obtained separately during the burst and slow phase of the EEG (SEP-burst and SEP-slow, respectively), which showed a two fold greater amplitude of N20 in the former than in the latter. This suggests enhanced responsiveness to the peripheral stimuli during the burst phase as compared with the slow phase. CSF and serum were positive for autoantibodies to NMDA receptors. The "burst and slow complexes" reported here are considered to be an atypical EEG pattern of a generalized epileptic phenomenon.
Department of Neurology, Kyoto University School of Medicine, Japan. akio@kuhp.kyoto-u.ac.jp
Akio
A
Ikeda
Masaru
M
Matsui
Yoshiki
Y
Hase
Takehumi
T
Hitomi
Yukitoshi
Y
Takahashi
Hiroshi
H
Shibasaki
Shun
S
Shimohama
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid; D003128:Coma; D004569:Electroencephalography; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D013226:Status Epilepticus / Q000188:drug therapy / Q000503:physiopathology*
D000927:Anticonvulsants; D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate