Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative method.
Photoacoustic imaging is a noninvasive biomedical imaging modality for visualizing the internal structure and function of soft tissues. Conventionally, an image proportional to the absorbed optical energy is reconstructed from measurements of light-induced acoustic emissions. We describe a simple iterative algorithm to recover the distribution of optical absorption coefficients from the image of the absorbed optical energy. The algorithm, which incorporates a diffusion-based finite-element model of light transport, converges quickly onto an accurate estimate of the distribution of absolute absorption coefficients. Two-dimensional examples with physiologically realistic optical properties are shown. The ability to recover optical properties (which directly reflect tissue physiology) could enhance photoacoustic imaging techniques, particularly methods based on spectroscopic analysis of chromophores.
Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK. bencox@medphys.ucl.ac.uk
Benjamin T
BT
Cox
Simon R
SR
Arridge
Kornel P
KP
Köstli
Paul C
PC
Beard
D000162:Acoustics; D000465:Algorithms; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009716:Numerical Analysis, Computer-Assisted; D019047:Phantoms, Imaging; D012031:Refractometry / Q000379:methods*; D012542:Scattering, Radiation; D041622:Tomography, Optical / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*