Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin.
We studied vancomycin and daptomycin susceptibility in methicillin-resistant Staphylococcus aureus from patients exposed to vancomycin, glycopeptide-intermediate S. aureus, and S. aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin.
Sakoulas
George
G
Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA. george_sakoulas@nymc.edu
Alder
Jeff
J
Thauvin-Eliopoulos
Claudie
C
Moellering
Robert C
RC
Eliopoulos
George M
GM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin