LRP6 holds the key to the entry of anthrax toxin.
In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two previously identified receptors for anthrax toxin.
Bann
James G
JG
Department of Chemistry, Wichita State University, Wichita, Kansas 67260, USA.
Cegelski
Lynette
L
Hultgren
Scott J
SJ
D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry* / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry* / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008954:Models, Biological; D011973:Receptors, LDL / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C555475:LRP6 protein, human; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D011973:Receptors, LDL; C030325:anthrax toxin