Plasmodium post-genomics: better the bug you know?
Since the publication of the sequence of the genome of Plasmodium falciparum, the major causative agent of human malaria, many post-genomic studies have been completed. Invaluably, these data can now be analysed comparatively owing to the availability of a significant amount of genome-sequence data from several closely related model species of Plasmodium and accompanying global proteome and transcriptome studies. This review summarizes our current knowledge and how this has already been--and will continue to be--exploited in the search for vaccines and drugs against this most significant infectious disease of the tropics.
Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Taco W A
TW
Kooij
Chris J
CJ
Janse
Andrew P
AP
Waters
D000818:Animals; D015870:Gene Expression; D018503:Genome, Protozoan; D010961:Plasmodium / Q000187:drug effects / Q000235:genetics* / Q000276:immunology / Q000502:physiology*; D020543:Proteome
D020543:Proteome