White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1.
Five feline-derived microsatellite markers were genotyped in a large pedigree of cats that segregates for ventral white spotting. Both KIT and EDNRB cause similar white spotting phenotypes in other species. Thus, three of the five microsatellite markers chosen were on feline chromosome B1 in close proximity to KIT; the other two markers were on feline chromosome A1 near EDNRB. Pairwise linkage analysis supported linkage of the white spotting with the three chromosome B1 markers but not with the two chromosome A1 markers. This study indicates that KIT, or another gene within the linked region, is a candidate for white spotting in cats. Platelet-derived growth factor alpha (PDGFRA) is also a strong candidate, assuming that the KIT-PDGFRA linkage group, which is conserved in many mammalian species, is also conserved in the cat.
Cooper
M P
MP
Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
Fretwell
N
N
Bailey
S J
SJ
Lyons
L A
LA
D000818:Animals; D002415:Cats / Q000033:anatomy & histology / Q000235:genetics*; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D005819:Genetic Markers; D006200:Hair Color / Q000235:genetics*; D008126:Lod Score; D018895:Microsatellite Repeats; D010641:Phenotype; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D012880:Skin Pigmentation / Q000235:genetics*
D005819:Genetic Markers; D019009:Proto-Oncogene Proteins c-kit