Bacteriocins Pep5 and epidermin inhibit Staphylococcus epidermidis adhesion to catheters.
Pep5 and epidermin bacteriocins were tested on clinical strains of Staphylococcus epidermidis and S. aureus isolated from catheter-related infections. These bacteriocins were inhibitory to several isolates at a concentration of 640 activity units mL(-1). The ability of bacteriocins in inhibiting adhesion of S. epidermidis to silicone catheters was evaluated. When Pep5 and epidermin were added to in vitro catheter colonization experiments, there was a significant decrease in the cell number of S. epidermidis adhered to silicone catheters. Bacteriocins used to decrease bacterial attachment to medical devices may represent a novel strategy to control catheter-related infections.
Departamento de Ciência de Alimentos, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, 91501-970, Porto Alerge, Brazil.
Mariana Buss Cezar
MB
Fontana
Maria do Carmo Freire
Mdo C
de Bastos
Adriano
A
Brandelli
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D001430:Bacteriocins / Q000494:pharmacology*; D002408:Catheters, Indwelling / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D010455:Peptides / Q000494:pharmacology*; D012828:Silicones; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010455:Peptides; D012828:Silicones; C050558:epidermin