Controlling biofilm formation with an N-halamine-based polymeric additive.
An N-halamine-based polymeric additive, poly[(6-morpholino-s-triazine-2,4-diyl)-N-chloro-[2,2,6,6-tetramethyl-4-piperidyl)imino]-hexamethylene[(2,2,6,6-4-piperidyl) imino]] (APA-1), was prepared in this study. The chemical structure of APA-1 was confirmed by iodometric titration, (1)H NMR, and (13)C NMR analysis. APA-1 was incorporated into polyurethane through solvent casting. The resultant materials demonstrated potent antimicrobial functions against Staphylococcus epidermidis. Zone of inhibition studies showed that APA-1 inactivated the bacteria through contact, without leaching out of the polyurethane samples. In vitro studies illustrated that APA-1-containing polyurethane could prevent the colonization and biofilm formation of S. epidermidis for at least 28 days.
Luo
Jie
J
Department of Human Ecology, University of Texas at Austin, 78712, USA.
Chen
Zhaobin
Z
Sun
Yuyu
Y
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001672:Biocompatible Materials; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D011108:Polymers / Q000494:pharmacology*; D011140:Polyurethanes; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes