Successful whole blood exchange by apheresis in a patient with acute cyclosporine intoxication without long-term sequelae.
Acute cyclosporine A (CsA) intoxication after organ transplantation may occur during the changeover from one form of drug to another, or from miscalculation of dosage. Sometimes, it may cause severe hepatotoxicity, nephrotoxicity and neurotoxicity. However, the therapeutic plasma exchange for the CsA intoxication was not established. Here, we present a case of very severe CsA intoxication after cardiac transplantation who recovered from intoxication without long-term sequelae via whole blood exchange; therapeutic erythrocytapheresis followed by total plasma exchange.
Kwon
Sung Uk
SU
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lim
Seong-Hoon
SH
Rhee
Il
I
Kim
Seon-Woon
SW
Kim
Jong-kyu
JK
Kim
Dae-Won
DW
Jeon
Eun-Seok
ES
D001781:Blood Component Removal; D016572:Cyclosporine / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy*; D017707:Erythrocyte Transfusion; D005078:Exchange Transfusion, Whole Blood / Q000379:methods*; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange
D007166:Immunosuppressive Agents; D016572:Cyclosporine