Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma.
BACKGROUND
Malignant brain tumors have been reported to occur after childhood irradiation more frequently than in the nonirradiated population.


CONCLUSIONS
In this study, we report the case of a 15-year-old boy treated for medulloblastoma with surgery and craniospinal radiotherapy, who developed a meningioma 18 years after initial treatment and subsequently an anaplastic astrocytoma 23 years after primary treatment. The meningioma was resected without complications. The patient is currently alive but with recurrent astrocytoma after a complete remission on temozolomide monotherapy. Second malignancies are a rare, potentially devastating risk in cancer survivors, with risk continuing lifelong.
Department of Radiation Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO 63110, USA. ahope@radonc.wustl.edu
Andrew J
AJ
Hope
David B
DB
Mansur
Pang-Hsien
PH
Tu
Joseph R
JR
Simpson
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001254:Astrocytoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D014057:Tomography, X-Ray Computed