Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a 2-year follow-up.
BACKGROUND
The aim of this clinical study was to evaluate the association of locally delivered doxycycline 10% with scaling and root planing in the periodontal treatment of smokers during a 2-year period.


METHODS
Forty-eight chronic periodontitis patients, presenting a minimum of four pockets (>or=5 mm) that bled on probing on anterior teeth were included. Patients were randomly assigned to receive one of the following treatments: scaling and root planing (SRP) and scaling and root planing followed by local application of doxycycline (SRP-D). Assigned treatments were performed at baseline and at 12 months. Clinical parameters, including probing depth (PD) and relative attachment level (RAL), were recorded at baseline; 45 days; 3, 6, and 12 months (retreatment); 45 days following retreatment; and at 15, 18, and 24 months.


RESULTS
In initially deep pockets (>or=7 mm), SRP-D showed greater PD reduction than SRP at 6 and 18 months (mean difference between groups of 1.18 and 1.73 mm, respectively; P <0.05) and greater RAL gain in all periods after 3 months (mean difference between groups of 1.16, 1.99, and 1.78 mm, at 6, 18, and 24 months, respectively; P <0.05). Also, the proportion of sites showing >or=2 mm PD reduction was greater for SRP-D at 6 months (81.2% x 50.8%; P <0.001) and at 24 months (65.5% x 46.5%; P = 0.01). As for RAL gain, this proportion was 34.4% and 18.1% for SRP-D and SRP at 24 months, respectively (P = 0.008).


CONCLUSIONS
The use of locally delivered doxycycline may constitute an important adjunct for the active and supportive treatments of severe periodontal disease in smokers.
Department of Periodontics and Prosthodontics, School of Dentistry at Piracicaba, State University of Campinas, São Paulo, Brazil.
Luciana
L
Machion
Denise Carleto
DC
Andia
Giovana
G
Lecio
Francisco Humberto
FH
Nociti
Márcio Zaffalon
MZ
Casati
Antonio Wilson
AW
Sallum
Enilson Antonio
EA
Sallum
D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000188:drug therapy; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000188:drug therapy; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy*; D011446:Prospective Studies; D016037:Single-Blind Method; D012907:Smoking
D000891:Anti-Infective Agents, Local; D004318:Doxycycline