Growth retardation and lethality induced by adriblastina in chick embryo.
The low (1.2 mg/kg) and high (2.4 mg/kg) therapeutic dose of adriblastina, dissolved in 0.04 ml of distilled water was injected into the chick embryo at different duration of the incubation. The control chick embryo received equal volume of distilled water at the same duration. All groups of embryo were collected on day 19 of gestation. The treated embryo showed growth retardation and lethality in a dose dependence response. The lethality and growth retardation in both treated groups were found significantly different (p<0.001) as compared with the control chick embryo. Similarly the groups treated on different days showed a time sequential effect on the developing chick embryo. Our observation had revealed that the drug is teratogenic to the chick embryo.
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Satya Narayan
SN
Shamal
Shashi Kant
SK
Pandey
Bimal Kishore
BK
Panda
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects*; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin