HLA-DRB1, -DQB1 alleles in head and neck carcinoma patients.
Certain HLA class II alleles have been reported to play a role in development or prevention of cervical carcinoma, an epithelial malignancy linked to human papillomavirus (HPV). In head and neck carcinomas, of which a subset is also HPV associated, the impact of HLA genes remains unknown. HLA-DRB1, -DQB1 alleles were determined in a comprehensive series of 162 head and neck carcinoma patients, for which 83 consecutive cadaveric organ donors of Finnish origin served as controls. DRB1*03 was associated with node-negative disease and DRB1*08 and 13 with small tumors; DRB1*04 was protective against disease relapse. Most alleles of borderline significance in this study act similarly in cervical carcinomas.
Department of Virology, Haartman Institute, University of Helsinki, Finland. walter.koskinen@helsinki.fi
W J
WJ
Koskinen
J
J
Partanen
A
A
Vaheri
L-M
LM
Aaltonen
D000483:Alleles; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D012189:Retrospective Studies
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains