Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men.
We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY (PYY), glucagon-like peptide-2 (GLP-2) and pancreatic polypeptide (PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12"), but not decanoic ("C10"), acid would decrease plasma ghrelin and increase PYY, GLP-2 and PP concentrations. Plasma hormone concentrations were measured in seven healthy men during 90-min intraduodenal infusions of: (i) C12, (ii) C10 or (iii) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10) and after a buffet-meal consumed following the infusion. C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Both C10 and C12 increased PP concentrations slightly (P < 0.05). We conclude that the effects of intraduodenal fatty acids on ghrelin, PYY and GLP-2 secretion are dependent on their chain length.
University of Adelaide, Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia.
Kate L
KL
Feltrin
Michael
M
Patterson
Mohammad A
MA
Ghatei
Stephen R
SR
Bloom
James H
JH
Meyer
Michael
M
Horowitz
Christine
C
Feinle-Bisset
D000328:Adult; D000818:Animals; D004386:Duodenum / Q000473:pathology; D005227:Fatty Acids / Q000737:chemistry* / Q000378:metabolism; D005247:Feeding Behavior; D054439:Ghrelin; D053767:Glucagon-Like Peptide 2; D004763:Glucagon-Like Peptides / Q000097:blood / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000737:chemistry*; D036361:Peptide Hormones / Q000097:blood / Q000737:chemistry*; D019894:Peptide YY / Q000097:blood / Q000737:chemistry*; D051381:Rats; D013997:Time Factors
D005227:Fatty Acids; D054439:Ghrelin; D053767:Glucagon-Like Peptide 2; D036361:Peptide Hormones; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D004763:Glucagon-Like Peptides