Effect of microcapsules containing TAK-778 on bone formation around osseointegrated implants: histomorphometric analysis in dogs.
OBJECTIVE
The aim of this study was to evaluate the in vivo effect of TAK-778 on osseointegration of titanium implants.


METHODS
Mandibular premolars were extracted from 8 dogs. After 3 months, 2 titanium implants were bilaterally placed, and each implantation site randomly received 1 of the following treatments: sustained-release microcapsules of TAK-778, placebo microcapsules, or no treatment. At 8 and 12 weeks after implantation, the hemi-mandibles containing the implants were removed, and processed for morphologic and histomorphometric analysis. Data were submitted to 2-way analysis of variance.


RESULTS
The histologic sections of the 3 experimental groups at 8 and 12 weeks did not show morphologic differences related to applied treatment. The percentage of bone-implant contact, mineralized bone matrix between implant threads, and mineralized bone matrix within mirror area were not affected either by treatments or evaluated periods.


CONCLUSIONS
No effect of TAK-778 was observed on osseointegration of titanium implants, which most likely occurred because microcapsules may not be retained and, therefore, available at the implant sites. An alternative is the manufacture of a release system, which can be immobilized on implant surface, ensuring the drug permanence in the implant site at least at the initial periods of bone formation.
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Brazil. adalrosa@forp.usp.br
Adalberto Luiz
AL
Rosa
Clícia Santos Rodrigues
CS
de Oliveira
Márcio Mateus
MM
Beloti
Samuel Porfírio
SP
Xavier
Paulo Tambasco
PT
de Oliveira
D000818:Animals; D001582:Benzothiepins / Q000008:administration & dosage / Q000627:therapeutic use*; D001857:Bone Matrix / Q000187:drug effects / Q000473:pathology; D002113:Calcification, Physiologic / Q000187:drug effects; D002214:Capsules; D003692:Delayed-Action Preparations; D015921:Dental Implants; D004285:Dogs; D008334:Mandible / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D010919:Placebos; D011897:Random Allocation; D013997:Time Factors; D014025:Titanium
D001582:Benzothiepins; D002214:Capsules; D003692:Delayed-Action Preparations; D015921:Dental Implants; D010919:Placebos; C120450:TAK 778; D014025:Titanium