Two novel furan derivatives from Phellinus linteus with anti-complement activity.
Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 microM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.
Min
Byung-Sun
BS
College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
Yun
Bong-Sik
BS
Lee
Hyeong-Kyu
HK
Jung
Hee-Jin
HJ
Jung
Hyun-Ah
HA
Choi
Jae-Sue
JS
D001487:Basidiomycota / Q000737:chemistry*; D003167:Complement Activation / Q000187:drug effects*; D003165:Complement System Proteins / Q000276:immunology*; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D005663:Furans; C512296:phellinusfuran A; C512297:phellinusfuran B; D003165:Complement System Proteins; C039281:furan