[Effect of bemithyl on sexual behavior and spermatogenesis in rats].
Bemithyl produced different influence on the sexual behavior (pairing motivation) and spermatogenesis in rats, depending on the dose and duration of drug administration. A three-day administration of bemithyl (20 and 200 mg/kg, p.o.) stimulated the sexual activity and spermatogenesis in male rats irrespective of the drug dose. The chronic administration of bemithyl over a period of 60 days led to a decrease in the male sexual activity and spermatogenesis index. This behavior can be related to the drug influence on the hypothalamus/pituitary structures responsible for the male rat generative function.
Bugaeva
L I
LI
Spasov
A A
AA
Kuzubova
E A
EA
D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects*
D001562:Benzimidazoles; D000697:Central Nervous System Stimulants; C049825:bemethyl