Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds.
OBJECTIVE
To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.


METHODS
Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (CII)-reactive antibodies and the pathological scores of CIA were assessed.


RESULTS
Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 +/- 3.35 days vs 16.56 +/- 4.75 days, P < 0.05) and higher level of CII-reactive antibodies (0.2274 +/- 0.1390 microg/ml vs 0.1101 +/- 0.0560 microg/ml, P < 0.05) were observed, but the pathological scores of CIA remained unchanged. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 +/- 3.43 scores vs 11.11 +/- 5.64 scores) and bone erosion (0.22 +/- 0.44 scores vs 1.67 +/- 1.50 scores) of CIA on NTG mice (P < 0.05), NTG YQXQFS group compared with NTG experimental group.


CONCLUSIONS
YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.
Department of Rheumatology and Clinic Immunology, The Second Xiangya Hospital of Central-South University, Changsha 410011. 13973127520@hnmcc.com
Fen
F
Li
Hong
H
Wu
Jun-wei
JW
Deng
Song-qing
SQ
Fan
Jing
J
Tian
Jie-sheng
JS
Gao
Ya-hui
YH
Zhu
Guang-xiu
GX
Lu
D000818:Animals; D000906:Antibodies / Q000097:blood; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D024043:Collagen Type II / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015804:HLA-DR4 Antigen / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout
D000906:Antibodies; D018501:Antirheumatic Agents; D024043:Collagen Type II; D004365:Drugs, Chinese Herbal; D015804:HLA-DR4 Antigen; C513942:yangqixue qufengshi recipe