Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression.
Cancer cell budding at the invasive margin has been associated with poor prognosis in rectal cancer. beta-Catenin is an adhesion protein involved in the nuclear Wnt/beta-catenin pathway, and mesenchymal transition of colorectal cancer cells. Hence, we investigated the relationship between cancer cell budding at the invasive margin, beta-catenin expression, and 5-year-survival in colorectal cancer. Four hundred and sixty six colorectal cancer specimens were analysed for budding margin, and 108 specimens from the same set for beta-catenin by immunohistochemistry. A budding margin was present in 24.0% of the cases and predicted a poor 5-year-survival (15.4%, P < 0.00001). Nuclear beta-catenin expression increased from the central area towards the invasive margin (P < 0.001), but did not predict budding. Budding margin is an independent factor associated with poor prognosis in colorectal cancer, and could be utilised in diagnostic pathology. Nuclear beta-catenin was often found at the invasive margin, but is unlikely to be the sole cause of budding.
Department of Pathology, Oulu University Hospital, University of Oulu, Aapistie 5, POB 5000, FIN-90014, Oulu, Finland.
Tuomo T
TT
Hörkkö
Kai
K
Klintrup
Johanna M
JM
Mäkinen
Juha B
JB
Näpänkangas
Hannu J
HJ
Tuominen
Jyrki
J
Mäkelä
Tuomo J
TJ
Karttunen
Markus J
MJ
Mäkinen
D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015588:Observer Variation; D011379:Prognosis; D012044:Regression Analysis; D016019:Survival Analysis; D051176:beta Catenin / Q000378:metabolism*
D009363:Neoplasm Proteins; D051176:beta Catenin