Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei.
A new biflavanoid, ent-naringeninyl-(I-3alpha,II-8)-4'-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC(50) 6.7 microM). Antitrypanosomal activity (IC(50) 0.87 microM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM).
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
Zakaria H
ZH
Mbwambo
Modest C
MC
Kapingu
Mainen J
MJ
Moshi
Francis
F
Machumi
Sandra
S
Apers
Paul
P
Cos
Daneel
D
Ferreira
Jannie P J
JP
Marais
Dirk
D
Vanden Berghe
Louis
L
Maes
Arnold
A
Vlietinck
Luc
L
Pieters
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D029760:Garcinia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D018314:Leishmania infantum / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism; D013636:Tanzania; D014345:Trypanosoma / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000981:Antiprotozoal Agents; D044946:Biflavonoids; D044004:Xanthones