Ovarian carcinoma with thyroid metastases causing clinical hypothyroidism: a case report.
BACKGROUND
Ovarian cancer is known to metastasize to the thyroid gland. Despite an incidence of ovarian metastasis to the thyroid of 3-15%, clinical hypothyroidism resulting from such metastasis has not yet been reported. We present a case of metastatic ovarian cancer to the thyroid resulting in clinical hypothyroidism.


METHODS
A 55-year-old woman with recurrent papillary adenocarcinoma of the ovary presented with fatigue, abdominal distention, lymphedema, and depression. Thyroid stimulating hormone was markedly elevated, and thyroid biopsy demonstrated bilateral metastatic ovarian carcinoma.


CONCLUSIONS
Although uncommon, metastatic disease to the thyroid should be considered when evaluating a patient with advanced ovarian cancer and clinical hypothyroidism.
Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CC-913, Boston, MA 02215, USA.
Lara M
LM
Skarf
Bruce J
BJ
Dezube
Bradley
B
Bryan
Anna
A
Berkenblit
D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000150:complications* / Q000556:secondary*