Synthetic derivatives of polyethyleneimine with enzyme-like catalytic activity (synzymes).
A synthetic polymer has been prepared which contains dodecyl groups (to bind small substrate molecules) and methyleneimidazole side chains (as nucleophilic catalytic sites) linked to a polyethyleneimine framework. This macromolecule, with a high local concentration of binding and catalytic groups, catalyzes the hydrolysis of uncharged nitrophenyl esters in water at pH 7 with rates markedly greater than previously observed with any other synthetic substances under similar conditions.
Biochemistry Division, Department of Chemistry, Northwestern University, Evanston, Illinois 60201.
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Klotz
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Royer
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Scarpa