Stem cells and cancer: two faces of eve.
Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better modes of treatment.
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. mfclarke@stanford.edu
Michael F
MF
Clarke
Margaret
M
Fuller
D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D013234:Stem Cells