Aerosolized ribavirin-induced reversible hepatotoxicity in a hematopoietic stem cell transplant recipient with Hodgkin lymphoma.
We describe a case of acute hepatic toxicity associated with aerosolized ribavirin in a bone marrow transplant recipient with documented respiratory syncytial virus infection. The temporal relationship with drug administration and the liver biopsy results suggested drug-induced hepatic injury. As the use of aerosolized ribavirin to treat respiratory syncytial virus infections continues, it is imperative that careful attention be paid to possible adverse effects of therapy in the high-risk population of immunosuppressed patients.
Department of Lymphoma and Myeloma, Section of Cytokines and Supportive Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Jorge
J
Chaves
Auris
A
Huen
Carlos
C
Bueso-Ramos
Amar
A
Safdar
Saroj
S
Vadhan-Raj
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000336:Aerosols; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001663:Bilirubin / Q000097:blood*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005260:Female; D006086:Graft vs Host Disease; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008111:Liver Function Tests; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use*; D033581:Stem Cell Transplantation / Q000009:adverse effects*
D000305:Adrenal Cortex Hormones; D000336:Aerosols; D000998:Antiviral Agents; D012254:Ribavirin; D001663:Bilirubin