[Effect of phenibut on the respiratory arrest caused by serotonin].
The role of the GABAergic system in mechanisms of the respiratory arrest caused by serotonin administration was studied in anaesthetized rats. Under normal conditions, the systemic administration of serotonin (20-60 mg/kg, i.v.) resulted in drastic changes of the respiratory pattern, whereby the initial phase of increased respiratory rate was followed by the respiratory arrest. The preliminary injection of phenibut (400 mg/kg, i.p.) abolished or sharply reduced the duration of the respiratory arrest phase induced by serotonin. Bilateral vagotomy following the phenibut injection potentiated the anti-apnoesic effect of phenibut, which was evidence of the additive action of vagotomy and phenibut administration. The mechanism of apnea caused by serotonin administration is suggested to include a central GABAergic element, which is activated by phenibut so as to counteract the respiratory arrest.
Tarakanov
I A
IA
Tarasova
N N
NN
Belova
E A
EA
Safonov
V A
VA
D000818:Animals; D001049:Apnea / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D014628:Vagotomy; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D018755:GABA Agonists; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid