Benzotetramisole: a remarkably enantioselective acyl transfer catalyst.
[reaction: see text] A commercially available pharmaceutical, tetramisole, was found to be a competent enantioselective acylation catalyst. Its benzannellated analogue, benzotetramisole (BTM), produced outstanding enantioselectivities in kinetic resolution of secondary benzylic alcohols.
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, USA. birman@wustl.edu
Vladimir B
VB
Birman
Ximin
X
Li
D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013773:Tetramisole / Q000031:analogs & derivatives* / Q000737:chemistry*
D001592:Benzyl Alcohols; C515434:benzotetramisole; D013773:Tetramisole