[Prognostic value of the inmunohïstochemical expression of protein p27KIP1 in laryngeal cancer].
In this paper we carried out an immunohistochemical study of protein p27KIP1 expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p27KIP1 expression at this level. Furthermore we have analysed the value of protein p27KIP1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p27KIP1 expression and other clinic and pathologic parameters.
Servicio ORL, Hospital Gutiérrez Ortega, Valdepeñas. cjangela@castillalamancha.es
M C
MC
García Lozano
J L
JL
Orradre Romero
M
M
Caro García
A
A
Martínez Alvarez
O
O
Lasso Luis
M A
MA
Piris Pinilla
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D010641:Phenotype; D011379:Prognosis
D050760:Cyclin-Dependent Kinase Inhibitor p27