Rediscovery of natural products using genomic tools.
A screening methodology called 'genomic screening' was established to identify natural products that can regulate cellular gene expression. Application of genomic screening to Keishi-bukuryo-gan (KBG), a Japanese herbal medicine formulation, identified a previously unnoticed transcriptional effect by linoleic acid, a known KBG component. The approach opens up a possibility to develop cell-permeable molecular tools for functional genomics research and sets a stage to evaluate the potential of natural products for transcription therapies.
CUNY-Hunter College, Department of Chemistry, 695 Park Avenue, New York, NY 10021, USA. akira.kawamura@hunter.cuny.edu
Akira
A
Kawamura
Angelika
A
Brekman
Yevgeniy
Y
Grigoryev
Tal H
TH
Hasson
Anna
A
Takaoka
Stephanie
S
Wolfe
Clifford E
CE
Soll
D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D016678:Genome / Q000235:genetics*; D006801:Humans; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D014470:Umbilical Cord / Q000187:drug effects / Q000378:metabolism
D001688:Biological Products