The hypothalamic H1 receptor: a novel therapeutic target for disrupting diurnal feeding rhythm and obesity.
Histamine-containing neurons and histamine H1 receptors are distributed within the brain and peripheral tissues. The results of physiological and pharmacological studies have revealed that brain histamine and H1 receptors are involved in the regulation of feeding and obesity in rodents. The adipocytokine leptin regulates feeding and obesity, partially through brain histamine. Furthermore, recent studies have provided evidence that regulation of the diurnal rhythm of feeding through H1 receptors is a crucial factor in the development of obesity. Thus, the regulation of H1 receptors is important for the control of energy metabolism, feeding rhythms and obesity in rodents.
Department of Internal Medicine 1, School of Medicine, Oita University, Hasama, Oita 879-5593, Japan. masaki@med.oita-u.ac.jp
Takayuki
T
Masaki
Hironobu
H
Yoshimatsu
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D006632:Histamine / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D020738:Leptin / Q000502:physiology*; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology; D011969:Receptors, Histamine H1 / Q000502:physiology*
D006634:Histamine H1 Antagonists; D020738:Leptin; D011969:Receptors, Histamine H1; D006632:Histamine