[Treatment of parturient paresis with high-dose calcium].
The goal of the present study was to evaluate a calcium dose that was higher than the conventional dose for treatment of parturient paresis in cows. Thirty cows with parturient paresis received 1000 ml of 40 per cent calcium borogluconate solution supplemented with 6 per cent magnesium hypophosphite. Cows in group A received 200 ml of the solution intravenously over a 10-minute period, and the remaining 800 ml via a slow intravenous drip over a six-hour period. Cows in group B received 500 ml of the solution intravenously over a 20-minute period, and the remaining 500 ml via a slow intravenous drip over a six-hour period. Afterwards, the cows were monitored continuously and examined every hour for eight hours. Samples of blood were collected from all the cows before treatment and at 10, 20, 40, 60, 90, 120, 180, 240, 300, 360, 420 and 480 minutes and 24, 48 and 72 hours after treatment. The concentrations of total calcium, ionised calcium, inorganic phosphorus and magnesium were determined. Cows that did not stand within 12 hours of treatment received one or more additional treatments. There was no significant difference in the recovery rate between the two groups. Of the 30 cows, 14 (47 per cent) rised after one treatment and 15 others (50 per cent) were cured after two or more treatments. One cow did not respond to repeated treatments and was euthanased four days after the start of treatment. The results of electrolyte analyses before treatment did not differ significantly between the two groups. In 27 (90 per cent) cows, the concentrations of calcium and inorganic phosphorus were lower than normal and in 3 (10 per cent) cows, only the concentration of inorganic phosphorus was lower than normal. The concentration of total calcium increased markedly ten minutes after the start of treatment in both groups, and at eight hours, the mean concentration of calcium was within the normal range. At 24 and 48 hours, the mean concentration of calcium was below normal, but at 72 hours it was again within the normal range. The concentration of inorganic phosphorus increased slowly in both groups, although it was not within the normal range at eight hours. In both groups, it achieved normal values at 24, 48 and 72 hours. The mean electrolyte concentrations did not differ significantly at any measuring point between cows that stood within eight hours of treatment and those that did not. Our results indicate that increasing the dose of calcium administered does not improve the recovery rate of cows with parturient paresis.
Braun
U
U
Departement für Nutztiere, Universität Zürich. ubraun@vetclinics.unizh.ch
Jehle
W
W
Siegwart
N
N
Bleul
U
U
Hässig
M
M
D000818:Animals; D019540:Area Under Curve; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006996:Hypocalcemia / Q000188:drug therapy / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D008274:Magnesium / Q000097:blood; D010319:Parturient Paresis / Q000188:drug therapy*; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome
D010758:Phosphorus; D008274:Magnesium; D002118:Calcium