Association between diabetes mellitus and adverse characteristics of breast cancer at presentation.
Type 2 diabetes mellitus is associated with increased incidence and inferior outcome of various malignancies. The aim of this study was to explore the impact of type 2 diabetes on breast cancer characteristics at presentation. The study population included 79 diabetic and 158 age-matched non-diabetic patients. Parity, country of birth, co-morbidity other than diabetes, and mode of diagnosis were similar in both groups. Mean body mass index (BMI) was higher among diabetic patients. Tumour stage and size were higher among diabetic patients and the differences remained significant after adjustment for BMI. Moreover, after adjustment for BMI, breast cancer among diabetic patients was more often hormone receptor negative. Our results show that diabetes mellitus is associated with negative prognostic factors at breast cancer presentation.
The Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel. wolf-i@inter.net.il
Ido
I
Wolf
Siegal
S
Sadetzki
Iris
I
Gluck
Bernice
B
Oberman
Merav
M
Ben-David
Moshe Zvi
MZ
Papa
Raphael
R
Catane
Bella
B
Kaufman
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis