Radiation modifiers: treatment overview and future investigations.
Many radiosensitizers are in current clinical use. In addition, a myriad of potential new targeted therapies, which may also interact with radiation, are in clinical development. The clinical utility of new targeted therapies, in combination with existing radiation sensitizers (chemotherapies) requires further evaluation, as does the understanding of their acute and late radiation effects. Free radical scavengers appear to show promise as radioprotectors, but data for mucoprotection are less convincing.
Thomas
C T
CT
Department of Radiation Oncology, David Geffen School of Medicine at University of California Los Angeles, 200 Medical Plaza, Suite B265, Los Angeles, CA 90095, USA.
Ammar
A
A
Farrell
J J
JJ
Elsaleh
H
H
D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D011880:Radiotherapy Planning, Computer-Assisted / Q000009:adverse effects / Q000379:methods
D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents