An iterative route to "decorated" ethylene glycol-based linkers.
Iterative copper-catalyzed cycloadditions of azides to alkynes were used to join functionalized triethylene glycol molecules to give "linkers" of defined lengths equipped with several different end-group functionalities.
Texas A&M University, Chemistry Department, P.O. Box 30012, College Station, Texas 77842, USA.
Genliang
G
Lu
Sang
S
Lam
Kevin
K
Burgess
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D003432:Cross-Linking Reagents; D003300:Copper; D019855:Ethylene Glycol