Impairment of cellular immunity in west Greenland sledge dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber.
Minke whale (Balaenoptera acutorostrata) blubber is rich in organohalogen contaminants, mercury, and n-3 fatty acids. In the present study we show that a daily intake of 50-200 g of minke whale blubber causes an impairment of the nonspecific and specific cellular immune system in the West Greenland sledge dog (Canis familiaris). Immune reactions were measured by mitogen (PHA, Con A) and antigen (KLH) intradermal testing, and as the study used exposure levels similar to those of Inuits and polar bears (Ursus maritimus), it is reasonable to infer that Inuits and polar bears suffer from similar decreased resistance to diseases. It is speculated that food sources are depleted by thinning sea ice due to climate change and that more research should assess the forecasted rise in additive immunopathy effects in polar bears. Additionally, our study suggests that the fatty acid composition may be of importance when investigating combined immunotoxic effects of contaminated food resources in future Inuit and polar bear studies.
Sonne
Christian
C
Department of Arctic Environment, National Environmental Research Institute, DK-4000 Roskilde, Denmark. csh@dmu.dk
Dietz
Rune
R
Larsen
Hans J S
HJ
Loft
Klaus Earl
KE
Kirkegaard
Maja
M
Letcher
Robert J
RJ
Shahmiri
Soheila
S
Móller
Per
P
D000818:Animals; D001110:Arctic Regions; D002980:Climate; D004285:Dogs; D004785:Environmental Pollutants / Q000633:toxicity*; D015525:Fatty Acids, Omega-3 / Q000032:analysis / Q000633:toxicity*; D005506:Food Contamination; D006116:Greenland; D006846:Hydrocarbons, Halogenated / Q000032:analysis / Q000633:toxicity*; D007111:Immunity, Cellular / Q000187:drug effects*; D008628:Mercury / Q000032:analysis / Q000633:toxicity*; D050636:Minke Whale; D001503:Ursidae
D004785:Environmental Pollutants; D015525:Fatty Acids, Omega-3; D006846:Hydrocarbons, Halogenated; D008628:Mercury