Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse.
Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats.
Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe-Universität, D-60590 Frankfurt am Main, Germany.
Friederike
F
Kienzler
Peter
P
Jedlicka
Mario
M
Vuksic
Thomas
T
Deller
Stephan W
SW
Schwarzacher
D000818:Animals; D002452:Cell Count / Q000379:methods; D016923:Cell Death / Q000528:radiation effects; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology*; D019580:Perforant Pathway / Q000528:radiation effects*