Metabolic regulation: fasting in the dark.
It is natural to starve. Learning how animals cope by juggling their scarce metabolic resources should therefore allow us to pinpoint physiological switches relevant to diabetes and cardiovascular disease. One known environmental trigger to metabolic adaptation is darkness; new studies suggest its endocrine mediator is 5' AMP.
MRC Laboratory of Molecular Biology, Division of Neurobiology, Cambridge, UK. mha@mrc-lmb.cam.ac.uk
Michael H
MH
Hastings
Andrew S I
AS
Loudon
D000249:Adenosine Monophosphate / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D006224:Cricetinae; D003624:Darkness; D005215:Fasting / Q000378:metabolism*; D005247:Feeding Behavior; D005786:Gene Expression Regulation; D006801:Humans; D008027:Light; D050356:Lipid Metabolism; D051379:Mice
D000249:Adenosine Monophosphate