Design of highly enantioselective organocatalysts based on molecular recognition.
[reaction: see text] Various organocatalysts have been designed based on molecular recognition to catalyze the asymmetric direct aldol reaction of ketones with aryl and alkyl alpha-keto acids, affording beta-hydroxyl carboxylic acids with a tertiary stereogenic center with excellent enantioselectivities of up to 98% ee. A linear effect was observed for the reaction, demonstrating a single molecule of the catalyst involved in the catalysis.
Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
Zhuo
Z
Tang
Lin-Feng
LF
Cun
Xin
X
Cui
Ai-Qiao
AQ
Mi
Yao-Zhong
YZ
Jiang
Liu-Zhu
LZ
Gong