Aromatic oligopeptides with chlorambucil moiety--synthesis and biological evaluation.
New aromatic oligopeptides with chlorambucil moiety have been synthesized. They showed antiproliferative and cytotoxic effect in the standard cell line of the mammalian tumor MCF-7.
Bartulewicz
Danuta
D
Department of Organic Chemistry, Medical University, 2A Mickiewicza St., 15-222 Białystok, Poland. dbartule@amb.edu.pl
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002699:Chlorambucil / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D009842:Oligopeptides; D002699:Chlorambucil