Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.
We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
Industrial Toxicology and Occupational Medicine Unit, Université catholique de Louvain, Belgium. Jean-Francois.Heilier@toxi.ucl.ac.be
Jean-François
JF
Heilier
Olivier
O
Donnez
Valérie
V
Van Kerckhove
Dominique
D
Lison
Jacques
J
Donnez
D001141:Aromatase / Q000378:metabolism*; D004715:Endometriosis / Q000201:enzymology*; D005260:Female; D006801:Humans; D009928:Organ Specificity; D010049:Ovarian Diseases / Q000201:enzymology*; D010532:Peritoneal Diseases / Q000201:enzymology*; D012002:Rectal Diseases / Q000201:enzymology*; D014018:Tissue Distribution; D014623:Vaginal Diseases / Q000201:enzymology*
D001141:Aromatase