Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production..
A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC beta-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC beta-lactamases.
Royal London Hospital, Whitechapel, UK. ajay.sinha@bartsandthelondon.nhs.uk
Ajay K
AK
Sinha
Stephen T
ST
Kempley
Elizabeth
E
Price
Bal K
BK
Sharma
David M
DM
Livermore
D016470:Bacteremia / Q000150:complications / Q000382:microbiology; D001426:Bacterial Proteins / Q000378:metabolism*; D002439:Cefotaxime / Q000494:pharmacology; D018550:Cephalosporin Resistance; D004756:Enterobacteriaceae Infections / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000382:microbiology*; D016920:Meningitis, Bacterial / Q000150:complications / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D020613:Morganella morganii / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism*
D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; D002439:Cefotaxime