Recurrent congenital heart block in neonatal lupus.
Congenital heart block (CHB) is the main complication of neonatal lupus (NL) and is strongly associated with the presence of anti-SSA/Ro and anti-SSB/La antibodies. The recurrence of CHB in subsequent pregnancies in mothers with these antibodies is uncommon, occurring in approximately 15% of cases. We describe here a case of recurrent CHB in a previously asymptomatic mother with Sjögren syndrome and discuss the current strategies for the prevention and treatment of CHB in NL.
Pediatric Cardiology Unit, Hospital Vall d' Hebron, Barcelona, Spain.
Maria C
MC
Escobar
José A
JA
Gómez-Puerta
Dimpna
D
Albert
Queralt
Q
Ferrer
Josep
J
Girona
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D005260:Female; D006327:Heart Block / Q000151:congenital* / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D008177:Lupus Vulgaris / Q000276:immunology* / Q000473:pathology; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012008:Recurrence; D012859:Sjogren's Syndrome
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies