A critical appraisal of methods used in early clinical development of novel drugs for the treatment of asthma.
Asthma is a heterogeneous disorder characterized by chronic airway inflammation, hyperresponsiveness and remodeling. Being the hallmark of asthma, airway inflammation has become the most important target for therapeutic agents. Consequently, during the past decade various semi-and non-invasive methods have been explored to sample the airway inflammation in asthma. In this review, we provide a practical overview of the current status of various sampling techniques including sputum induction, exhaled breath analysis, and bronchoprovocation tests (BPTs). We focus on their applicability for monitoring in clinical practice and in intervention trials in asthma.
Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands.
J D
JD
Boot
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P
Panzner
Z
Z
Diamant
D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D003948:Diagnostic Techniques, Respiratory System / Q000592:standards*; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015507:Drugs, Investigational