Gait characteristics in nondisabled community-residing nonagenarians.
OBJECTIVE
To determine gait performance in community-residing nonagenarians.


METHODS
Nested case-control study.


METHODS
Community.


METHODS
Thirty-one nondisabled nonagenarians (17 women) and 170 young-old controls (age range, 70-85y) participating in a longitudinal study.


METHODS
Not applicable.


METHODS
Systematic clinical and quantitative gait assessments. We also examined the association of gait velocity with death over a 1-year period.


RESULTS
Nonagenarian men had better performance on all quantitative gait parameters examined compared with women. Male sex (beta=.58; 95% confidence interval [CI], 9.95-38.89) and depressive symptoms (beta=-.34; 95% CI, -6.73 to -0.04) were independently associated with gait velocity in multivariate linear regression models. The 6 hypertensive nonagenarians on angiotensin-converting enzyme (ACE) inhibitors had faster gait velocity (median, 103.1cm/s) compared with the 8 hypertensive nonagenarians not on ACE inhibitors (median, 77.5cm/s; P=.029). Nonagenarians had worse quantitative gait parameters compared with the young-old controls, although the differences were less marked when subjects with clinically normal gaits in both groups were compared. Gait velocity did not predict survival over 1-year follow-up.


CONCLUSIONS
Gait characteristics in nondisabled community-residing nonagenarians are associated with male sex, depressive symptoms, and medications. The quantitative gait measures in this sample of nondisabled nonagenarians provide a yardstick to compare younger-age groups.
Division of Geriatrics, New York University Medical Center, New York, USA.
Mahesh
M
Krishnamurthy
Joe
J
Verghese
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D005684:Gait / Q000502:physiology*; D015577:Geriatric Assessment; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D012737:Sex Factors
D000806:Angiotensin-Converting Enzyme Inhibitors