Alveolar cleft osteoplasty using tissue-engineered osteogenic material.
The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.
Hibi
H
H
Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan. hibihi@med.nagoya-u.ac.jp
Yamada
Y
Y
Ueda
M
M
Endo
Y
Y
D000539:Alveolar Process / Q000002:abnormalities*; D000543:Alveoloplasty / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D008437:Maxilla / Q000002:abnormalities* / Q000601:surgery; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D010012:Osteogenesis / Q000502:physiology; D017713:Platelet Transfusion; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed