Voriconazole therapeutic drug monitoring.
We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P<0.025) between disease progression and drug concentration was detected. Favorable responses were observed in 10/10 patients with concentrations above 2.05 microg/ml, while disease progressed in 44% (n=18) of patients with concentrations below 2.05 microg/ml.
Smith
J
J
University of Wisconsin, Department of Medicine, Madison, WI 53792, USA.
Safdar
N
N
Knasinski
V
V
Simmons
W
W
Bhavnani
S M
SM
Ambrose
P G
PG
Andes
D
D
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000097:blood*; D018450:Disease Progression; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000097:blood*; D012189:Retrospective Studies; D014230:Triazoles / Q000097:blood*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole