Profile of serum S100beta levels during maturation in fetal and neonatal sheep.
Serum levels of the protein S-100beta are dependent on three factors: rate of production, permeability of the blood-brain barrier, and rate of clearance. In the developing fetus and neonate all of these factors change at different rates. This study was performed to determine how serum S-100 levels varied during fetal and early postnatal life. Blood samples were obtained from 41 fetal and neonatal lambs. The blood was separated in a centrifuge and the serum drawn off and assayed for S-100beta using a commercially available radioimunoassay kit. S-100beta did not appear in the blood until halfway through pregnancy. Thereafter, levels steadily increased until 1 month after birth. Following this, S-100beta levels decreased progressively until by 1 year of age, they had reached a plateau. S-100beta levels change significantly with normal fetal and neonatal maturation. Valid interpretation of other data from subjects of similar developmental stage must take into consideration this physiological variation.
Department of Pediatric Cardiac Surgery, University of California-San Francisco, San Francisco, CA, USA.
Andrew J
AJ
Parry
D Michael
DM
McMullan
Susan
S
Yelich
Frank L
FL
Hanley
D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000502:physiology*; D001812:Blood-Brain Barrier / Q000196:embryology / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000502:physiology*; D011247:Pregnancy; D009418:S100 Proteins / Q000097:blood*; D012756:Sheep
D009418:S100 Proteins