Antineoplastic activity of selected constituents of Duguetia glabriuscula.
The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower than 25 microg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.
Laboratório de Culturas Celulares, Departamento de Farmácia-Bioquímica, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil. mfcmatos@nin.ufms.br
M F C
MF
Matos
L I S P
LI
Leite
D
D
Brustolim
J M
JM
de Siqueira
C A
CA
Carollo
A R
AR
Hellmann
N F G
NF
Pereira
D B
DB
da Silva
D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000633:toxicity; D006801:Humans; D020128:Inhibitory Concentration 50; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012855:Sitosterols / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011084:Polycyclic Aromatic Hydrocarbons; D012855:Sitosterols; C460801:polycarpol; C025473:gamma-sitosterol; D002945:Cisplatin