Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery.
Formulation of proteins/peptides for therapeutic uses has often posed some challenges to drug formulators. The main problem is the relatively weak forces involved in the native conformation of these proteins and so making them quite labile. Furthermore, their susceptibility to proteolytic enzymes in the gut makes oral administration quite challenging. While various routes like, ocular, transdermal, nasal and buccal have been tried, none of these routes has proved to be a potential alternative to the invasive injection. However, various studies have been performed on the formulation of these proteins as aerosols for pulmonary delivery and promising results have been obtained. This article looks at the prospects of inhaled proteins as a delivery route for systemic activity.
Shoyele
Sunday A
SA
3M Health Care Ltd., Morley Street, Loughborough, Leicestershire LE11 1EP, United Kingdom. sashoyele@mmm.com
Slowey
Alex
A
D000280:Administration, Inhalation; D000336:Aerosols; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009330:Nebulizers and Vaporizers; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry
D000336:Aerosols; D010455:Peptides; D011506:Proteins