Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum.
A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2beta,15alpha,20alpha-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2beta-O-(2'-angelate)-beta-D-glucopyranoside, on the basis of spectroscopic analysis ((1)H NMR, (13)C NMR, HMQC, HMBC, NOESY), and was confirmed by X-ray crystallographic analysis. Sylviside (1) displayed weak cytotoxicity against HeLa WT (human epitheloid cervical carcinoma) cells and was also evaluated for its effects on reversing multidrug resistance in HeLa cells overexpressing MDR1.
Department of Pharmacognosy and Botany, Vitebsk State University, Republic of Belarus.
Mira M
MM
Konopleva
Irena
I
Matławska
Małgorzata
M
Wojcińska
Ahmed A
AA
Ahmed
Maria
M
Rybczyńska
Anna
A
Paszel
Shinji
S
Ohta
Toshifumi
T
Hirata
Wiesława
W
Bylka
Tom J
TJ
Mabry
John F
JF
Cannon
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D019450:Genes, MDR / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036622:Gnaphalium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D002094:Republic of Belarus
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005960:Glucosides; C509938:sylviside