Genetic basis of tetracycline and minocycline resistance in potentially probiotic Lactobacillus plantarum strain CCUG 43738.
The potentially probiotic strain Lactobacillus plantarum CCUG 43738, which displayed atypical phenotypic resistance to tetracycline (MIC, 512 microg/ml) and minocycline (MIC, 256 microg/ml), was found to contain a tet(S) gene located on a plasmid of approximately 14 kb. Plasmid curing with novobiocin eliminated this plasmid and restored the tetracycline-susceptible phenotype of the host strain.
Laboratory of Microbiology, Ghent University, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium. geert.huys@UGent.be
Geert
G
Huys
Klaas
K
D'Haene
Jean
J
Swings
D001483:Base Sequence; D048191:Lactiplantibacillus plantarum / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010957:Plasmids; D019936:Probiotics; D013753:Tetracycline Resistance
D008911:Minocycline