Percutaneous vertebroplasty for osteoporotic compression fracture: multivariate study of predictors of new vertebral body fracture.
OBJECTIVE
To investigate the risk factors and relative risk of new compression fractures following vertebroplasty.


METHODS
Initially, we enrolled 104 consecutive patients with vertebral compression fractures caused by osteoporosis. A total of 83 of the 104 patients visited our hospital for follow-up examinations for more than 4 weeks after vertebroplasty. Logistic regression analysis of the data obtained from these 83 patients was used to determine relative risks of recurrent compression fractures, using 13 different factors.


RESULTS
We identified 59 new fractures in 30 of the 83 patients: 41 new fractures in vertebrae adjacent to treated vertebrae; and 18 new fractures in vertebrae not adjacent to treated vertebrae. New fractures occurred in vertebrae adjacent to treated vertebrae significantly more frequently than in vertebrae not adjacent to treated vertebrae. Only cement leakage into the disk was a significant predictor of new vertebral body fracture after vertebroplasty (odds ratio = 4.633). None of the following covariates were associated with increased risk of new fracture: age, gender, bone mineral density, the number of vertebroplasty procedures, the number of vertebrae treated per procedure, the cumulative number of vertebrae treated, the presence of a single untreated vertebra between treated vertebrae, the presence of multiple untreated vertebrae between treated vertebrae, the amount of bone cement injected per procedure, the cumulative amount of bone cement injected, cement leakage into the soft tissue around the vertebra, and cement leakage into the vein.
Komemushi
Atsushi
A
Department of Radiology, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka, 570-8507, Japan. kome64@yo.rim.or.jp
Tanigawa
Noboru
N
Kariya
Shuji
S
Kojima
Hiroyuki
H
Shomura
Yuzo
Y
Komemushi
Sadao
S
Sawada
Satoshi
S
D000369:Aged, 80 and over; D002484:Cementation; D005260:Female; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000473:pathology; D011237:Predictive Value of Tests; D012008:Recurrence; D012044:Regression Analysis; D016103:Spinal Fractures / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013904:Thoracic Vertebrae / Q000293:injuries* / Q000473:pathology; D013997:Time Factors