Growth factor receptors in helminth parasites: signalling and host-parasite relationships.
Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.
Unité Inserm 547, Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex, France. colette.dissous@pasteur-lille.fr
Colette
C
Dissous
Naji
N
Khayath
Jérôme
J
Vicogne
Monique
M
Capron
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism*; D006376:Helminths / Q000378:metabolism*; D006790:Host-Parasite Interactions; D020935:MAP Kinase Signaling System; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction
D018125:Receptors, Transforming Growth Factor beta; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin