Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods.
Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99mTc-pertechenate and 67Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of 99mTc-pertechenate results did not demonstrate any functional differences between pre- versus post transplant periods. Results of the 67Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.
Coracin
F L
FL
BMT Unit, Hematology and Blood Transfusion Center (Hemocentro), State University of Campinas, São Paulo, Brazil.
Pizzigatti Correa
M E
ME
Camargo
E E
EE
Peterson
D E
DE
de Oliveira Santos
A
A
Vigorito
A C
AC
Borba Oliveira
G
G
de Brito Eid
K A
KA
Zulli
R
R
De Souza
C A
CA
D000328:Adult; D005260:Female; D005708:Gallium / Q000378:metabolism; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000379:methods*; D012469:Salivary Glands / Q000000981:diagnostic imaging* / Q000293:injuries* / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D014987:Xerostomia / Q000209:etiology / Q000378:metabolism
D013667:Technetium; D005708:Gallium