Molecular nature of methicillin-resistant Staphylococcus aureus derived from explosive nosocomial outbreaks of the 1980s in Japan.
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) with Panton-Valentine leukocidin (PVL) genes is increasing worldwide. Nosocomial outbreak-derived (hospital-acquired) MRSA (HA-MRSA) in Japan in the 1980s was also largely PVL(+). PVL(+) HA-MRSA and CA-MRSA shared the same multi-locus sequence type (ST30) and methicillin resistance cassette (SCCmecIV), but were divergent in oxacillin resistance, spa typing, PFGE analysis or clfA gene analysis. PVL(+) HA-MRSA, which probably originated in PVL(+)S. aureus ST30, was highly adhesive (carrying cna and bbp genes), highly-toxic (carrying luk(PV) and sea genes) and highly drug-resistant. PVL(+) HA-MRSA was once replaced by other PVL(-) HA-MRSA (e.g., ST5), and is re-emerging as CA-MRSA.
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Niigata, Japan.
Ikue
I
Taneike
Taketo
T
Otsuka
Soshi
S
Dohmae
Kohei
K
Saito
Kyoko
K
Ozaki
Misao
M
Takano
Wataru
W
Higuchi
Tomomi
T
Takano
Tatsuo
T
Yamamoto
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000235:genetics*; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D004196:Disease Outbreaks; D005098:Exotoxins / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007956:Leukocidins; D008712:Methicillin / Q000627:therapeutic use; D016106:Methicillin Resistance / Q000187:drug effects / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin