Small ciliary body tumors: ultrasound biomicroscopic assessment and follow-up of 42 patients.
OBJECTIVE
Detecting and following small tumors of the ciliary body is a particular challenge because of their location. Recently high-frequency ultrasound biomicroscopy (UBM) has been used to assist in this task. The aim of this study was to evaluate this subset of small ciliary body tumors through the use of UBM.


METHODS
Retrospective, noncomparative case series.


METHODS
Forty-two patients with small ciliary body tumors (less than 4 mm) from our institution were included in the study with a median follow-up of 4.3 years. UBM was used to assess tumor characteristics including height, location, and internal and external features. The data were collected longitudinally, and statistical analysis was performed.


RESULTS
Median initial tumor height was 2.05 mm (range 1.1 to 3.8 mm) as measured by UBM. By 5 years after diagnosis, five tumors (12%) exhibited growth. The overall mean growth rate was 0.026 mm per year (P = .00007). The most rapid period of growth was in the first year after diagnosis (growth rate 0.128 mm per year), after which the mean tumor size appeared to stabilize.


CONCLUSIONS
UBM is a valuable tool for detecting and following small ciliary body tumors (less than 4 mm), as these lesions may go undetected by other methods. Despite the potential for local extension into the iris or choroid, few of the tumors in this study exhibited growth, suggesting that many of these tumors can be managed conservatively. UBM can be used to assess various internal tumor features; however, arriving at a specific diagnosis without histologic correlation is difficult.
Weisbrod
Daniel J
DJ
Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Pavlin
Charles J
CJ
Emara
Khaled
K
Mandell
Mark A
MA
McWhae
John
J
Simpson
E Rand
ER
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002924:Ciliary Body / Q000000981:diagnostic imaging* / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D032801:Iridectomy; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy