[Elimination of chromosome aberrations in lymphocyte cultures of the peripheral blood in people at remote time after acute irradiation].
The changes in registered levels of chromosome aberrations are studied in the peripheral blood lymphocyte cultures of patients irradiated in result of Chernobyl accident. All 71 patients were examined with a different frequency for different survival patients. The initial evaluations of the doses for them by the average frequency of dicentrics were realized at the nearest terms after the irradiation (from 0.2 before 9.8 Gy for different patients). Repeated blood samples were collected during 6 years after the accident. On the whole the model of exponential type Y(T)/Y(0) = c + exp(b(0) + b(1)T), where Y(T)--the frequency dicentrics at the time of examinations; Y(0)--the originally discovered dicentric frequencies; T--the time past after irradiation (days) was the most adequate for the quantitative description of the elimination of cytogenetical indices associated with different types of unstable chromosome aberrations. Also as a result of this study high individual variability of the elimination rate of the chromosome aberrations and its dependence from the value of the originally evaluated dose were discovered.
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Dudochkina
D000208:Acute Disease; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics*; D013997:Time Factors; D014455:Ukraine