The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet.
The effect of tocopheryl phosphate on atherosclerosis progression has been studied in rabbits, fed with a 2% cholesterol diet and compared with an equivalent amount of alpha-tocopheryl acetate. The results show that the atherosclerotic-preventing effect of the phosphate derivative was more pronounced than that of the acetate derivative. alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative.
Negis
Yesim
Y
Department of Biochemistry, Faculty of Medicine, Marmara University, 81326 Haydarpasa, Istanbul, Turkey.
Aytan
Nurgül
N
Ozer
Nesrin
N
Ogru
Esra
E
Libinaki
Roksan
R
Gianello
Robert
R
Azzi
Angelo
A
Zingg
Jean-Marc
JM
D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D050197:Atherosclerosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D018955:CD36 Antigens / Q000096:biosynthesis; D002784:Cholesterol / Q000008:administration & dosage / Q000378:metabolism; D004036:Diet, Atherogenic; D005786:Gene Expression Regulation / Q000187:drug effects; D011817:Rabbits; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000924:Anticholesteremic Agents; D018955:CD36 Antigens; C012552:alpha-tocopherol phosphate; D002784:Cholesterol; D024502:alpha-Tocopherol; D024505:Tocopherols