Type III secretion gets an LcrV tip.
Type III secretion is used by many Gram-negative pathogenic bacteria to inject effector proteins into eukaryotic host cells. Effector delivery requires a secretion apparatus, called an injectisome or needle complex, and the assembly of a translocation pore in a target-cell membrane. Recent work provides evidence that enlightens the view of how pore assembly might occur and of how the injectisome and the pore might be linked.
Mota
Luís Jaime
LJ
Centre for Molecular Microbiology and Infection, Imperial College London, Flowers Building, Armstrong Road, London, UK, SW7 2AZ. j.mota@imperial.ac.uk
D000942:Antigens, Bacterial / Q000235:genetics / Q000502:physiology*; D052899:Pore Forming Cytotoxic Proteins; D015007:Yersinia / Q000235:genetics / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure
D000942:Antigens, Bacterial; C043908:LcrV protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins