[Effect of N-stearoylethanolamine on the level of stable NO metabolites in different pathological conditions which are accompanied by oxidative stress].
The effects of N-stearoylethanolamine (NSE) at the level of stable NO metabolites--NO2- NO3- under different pathological conditions which were accompanied by oxidative stress and NO disbalance were studied. It was found that NSE promoted the increasing of NO metabolites level on the animal models with deficit of NO compared to control and evoked decreasing content of NO2- and NO3- under pathological conditions with NO overproduction. It is suppoused, that NSE effects could be determined, by its ability to modulate the the activity of NO-synthase izoformes.
N M
NM
Hula
H V
HV
Kosiakova
N L
NL
Kindruk
T O
TO
Khmel'
D000818:Animals; D004194:Disease; D004195:Disease Models, Animal; D004983:Ethanolamines / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013229:Stearic Acids / Q000494:pharmacology*
D004983:Ethanolamines; D007155:Immunologic Factors; C408368:N-stearoylethanolamine; D009566:Nitrates; D009573:Nitrites; D013229:Stearic Acids; D009569:Nitric Oxide