Quantitative modeling of dielectrophoretic traps.
We present quantitative modeling software for simulating multiple forces acting on a single particle in a microsystem. In this paper, we focus on dielectrophoretic (DEP) trapping of single cells against fluid flow. The software effectively models the trapping behavior for a range of particles including beads, mammalian cells, viruses, and bacteria. In addition, the software can be used to reveal useful information about the DEP traps - such as multipolar DEP force effects, trap size-selectivity, and effects from varying the flow chamber height. Our modeling software thus serves as a predictive tool, enabling the design of novel DEP traps with superior performance over existing trap geometries. In addition, the software can evaluate a range of trap dimensions to determine the effects on trapping behavior, thus optimizing the trap geometry before it is even fabricated. The software is freely available to the scientific community at: .
Rosenthal
Adam
A
Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA. voldman@mit.edu
Taff
Brian M
BM
Voldman
Joel
J
D003198:Computer Simulation; D004586:Electrophoresis / Q000295:instrumentation* / Q000379:methods*; D008962:Models, Theoretical; D012984:Software