Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor.
A primary extramedullary myeloid cell tumor (pEMT) of an inguinal lymph node was completely excised without subsequent anti-tumor therapy in a 6-year-old child. Clinical observation and monitoring of blood and bone marrow (BM) did not reveal any pathologic results before 32 months, when a precursor B lymphoblastic leukemia was diagnosed. Identical T-cell receptor gamma rearrangement in nodal pEMT and in precursor B lymphoblastic leukemia in BM indicates a clonal relationship of these two tumors.
Department of Oncology/Hematology, University Children's Hospital Basel, Basel, Switzerland.
Gabor
G
Szinnai
Sergio B
SB
Cogliatti
Pierino
P
Avoledo
Stephan
S
Dirnhofer
Ulrico
U
Schmid
Thomas
T
Kühne
D000208:Acute Disease; D000951:Antigens, Neoplasm / Q000096:biosynthesis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D020732:Cytogenetic Analysis; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D016133:Polymerase Chain Reaction / Q000379:methods; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis / Q000235:genetics; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D016692:Receptors, Antigen, T-Cell, gamma-delta