Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression.
Cancer cell budding at the invasive margin has been associated with poor prognosis in rectal cancer. beta-Catenin is an adhesion protein involved in the nuclear Wnt/beta-catenin pathway, and mesenchymal transition of colorectal cancer cells. Hence, we investigated the relationship between cancer cell budding at the invasive margin, beta-catenin expression, and 5-year-survival in colorectal cancer. Four hundred and sixty six colorectal cancer specimens were analysed for budding margin, and 108 specimens from the same set for beta-catenin by immunohistochemistry. A budding margin was present in 24.0% of the cases and predicted a poor 5-year-survival (15.4%, P < 0.00001). Nuclear beta-catenin expression increased from the central area towards the invasive margin (P < 0.001), but did not predict budding. Budding margin is an independent factor associated with poor prognosis in colorectal cancer, and could be utilised in diagnostic pathology. Nuclear beta-catenin was often found at the invasive margin, but is unlikely to be the sole cause of budding.
Hörkkö
Tuomo T
TT
Department of Pathology, Oulu University Hospital, University of Oulu, Aapistie 5, POB 5000, FIN-90014, Oulu, Finland.
Klintrup
Kai
K
Mäkinen
Johanna M
JM
Näpänkangas
Juha B
JB
Tuominen
Hannu J
HJ
Mäkelä
Jyrki
J
Karttunen
Tuomo J
TJ
Mäkinen
Markus J
MJ
D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015588:Observer Variation; D011379:Prognosis; D012044:Regression Analysis; D016019:Survival Analysis; D051176:beta Catenin / Q000378:metabolism*
D009363:Neoplasm Proteins; D051176:beta Catenin