Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation.
Acute renal failure (ARF) is a common cause of mortality and morbidity in hospitalized patients. Ischemia is an important cause of ARF, and ARF caused by ischemic injury is referred to as ischemic acute tubular necrosis (ATN). There is growing evidence from models that ischemic ATN is associated with intrarenal inflammation. Consequently, intrarenal inflammation is an attractive target for the development of novel drug therapies for ARF. This review outlines ischemic ATN models, the pathophysiological roles of inflammatory cells such as T and B cells in ischemic ATN models, and effective T and B cell therapeutic reagents.
Ikeda
Masahiro
M
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-Nishi, Miyazaki 889-2192, Japan.
Prachasilchai
Worapat
W
Burne-Taney
Melissa J
MJ
Rabb
Hamid
H
Yokota-Ikeda
Naoko
N
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000098:blood supply; D007683:Kidney Tubular Necrosis, Acute / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D020411:Oligonucleotide Array Sequence Analysis; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009173:Mycophenolic Acid