[Relationship between expression of inducible nitric oxide synthase and proliferative potency of endothelium in hemangioma in infants].
OBJECTIVE
To investigate relationship between expression of inducible nitric oxide synthase (iNOS) and proliferative potency of endothelium in hemangioma (HM).


METHODS
Immunohistochemical staining was used to detect expression of iNOS and Ki-67 protein in 49 cases of HM and 29 cases of vascular malformation (VM).


RESULTS
Expressive rate of iNOS and Ki-67 protein of 49 cases of HM was 38% and (10.98 +/- 7.93)%. Expressive rate of iNOS and Ki-67 protein of 29 cases of VM was respectively 3% and (0.03 +/- 0.19)%. The expressive rate of iNOS and Ki-67 protein of HM was significantly higher than that of VM (P = 0.001 and 0). The expressive rate of Ki-67 protein of HM of proliferative phase was (12.67 +/- 7.65)% , which was significantly higher than that of HM of extinctive phase, (7.27 +/- 7.49)% (P = 0.028).


CONCLUSIONS
Expression of iNOS and Ki-67 protein of HM is significantly higher than that of VM, and the proliferative potency of HM is significantly higher than that of VM.
Department of Oral and Maxillofacial Surgery, Department of Pathology, the Second Affiliated Hospital, SUN Yat-sen University, Guangzhou 510120, China.
Jin-song
JS
Li
Hai-gang
HG
Li
Wei-liang
WL
Chen
Xuan-ling
XL
He
Zhao-hui
ZH
Yang
Hui-lin
HL
Cheng
D002675:Child, Preschool; D004727:Endothelium / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology; D005260:Female; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007223:Infant; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D009389:Neovascularization, Pathologic / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*
D019394:Ki-67 Antigen; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II