Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo-controlled study.
OBJECTIVE
To study the effect of high doses of thiamine (250 mg/day) and pyridoxine (200 mg/day) supplementation on plasma levels of advanced glycation end products and other oxidative stress markers in hemodialysis patients.


METHODS
An interventional survey.


METHODS
This study was conducted at an outpatient nephrology clinic. INTERVENTION AND PATIENTS: We performed a randomized placebo-controlled study over 8 weeks in 50 patients (53% men, age 52.9 +/- 3.4 years) on regular hemodialysis.


METHODS
The patients were divided into 2 groups of 25 patients in each arm. Before starting the study, the patients in both groups were matched by age, gender, inflammatory profile (plasma interleukin [IL]-6 and high-sensitivity C-reactive protein [hsCRP]), and nutritional status (subjective global assessment and protein nitrogen appearance).


RESULTS
In all, 40 of 50 patients completed the study (19 patients in the vitamin group and 21 in the placebo group). Serum albumin, plasma hsCRP, IL-6, advanced oxidation protein products, pentosidine and 8-hydroxy-2'-deoxyguanosine were measured before and after treatment in each group. In both groups, over 8 weeks of follow-up, no significant differences could be observed in oxidative stress, inflammatory, or nutritional markers.


CONCLUSIONS
There was no evidence showing that high doses of thiamine and pyridoxine affects oxidative stress in hemodialysis patients.
Faculdade Evangélica do Paraná-Brazil, Paraná, Brazil. marcelo.mazza.do.nascimento@ki.se
Marcelo M
MM
Nascimento
Mohamed E
ME
Suliman
Yukio
Y
Murayama
Melissa
M
Nihi
Shirley Y
SY
Hayashi
Peter
P
Stenvinkel
Miguel C
MC
Riella
Bengt
B
Lindholm
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress / Q000187:drug effects*; D010919:Placebos; D011736:Pyridoxine / Q000008:administration & dosage*; D006435:Renal Dialysis; D013831:Thiamine / Q000008:administration & dosage*; D016896:Treatment Outcome
D015415:Biomarkers; D017127:Glycation End Products, Advanced; D015850:Interleukin-6; D010919:Placebos; D002097:C-Reactive Protein; D011736:Pyridoxine; D013831:Thiamine