Nicotine an efficient tool of the neurobiological research today, the tool of treatment tomorrow?
Nicotine is a very widely used drug of abuse, which has many neurovegetative behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptor. Cholinergic receptors can be divided into two types, muscarinic and nicotinic, based on the pharmacological action of various agonists and antagonists. This review summarises the major recent findings of nicotine effects in order to show the use of this drug in the neurophysiological research and namely as a potential tool for the treatment of some brain disorders.
Institute of Physiology of the First Faculty of Medicine, Charles University in Prague, Czech Republic. vladimir.riljak@lf1.cuni.cz
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Langmeier
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009538:Nicotine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D018722:Nicotinic Agonists / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy; D011950:Receptors, Cholinergic / Q000502:physiology; D012907:Smoking
D000975:Antioxidants; D005731:Ganglionic Stimulants; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D011950:Receptors, Cholinergic; D009538:Nicotine