Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk nuclear test site.
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.
Takeichi
Nobuo
N
Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
Hoshi
Masaharu
M
Iida
Shozo
S
Tanaka
Kimio
K
Harada
Yuka
Y
Zhumadilov
Zhaxybay
Z
Chaizhunusova
Nailya
N
Apsalikov
Kazbek N
KN
Noso
Yoshihiro
Y
Inaba
Toshiya
T
Tanaka
Kenichi
K
Endo
Satoru
S
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle / Q000706:statistics & numerical data; D002467:Cell Nucleus / Q000473:pathology* / Q000528:radiation effects*; D002648:Child; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D007623:Kazakhstan / Q000453:epidemiology; D008214:Lymphocytes / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D015162:Micronucleus Tests / Q000706:statistics & numerical data; D008875:Middle Aged; D009689:Nuclear Warfare / Q000706:statistics & numerical data; D011832:Radiation Injuries / Q000453:epidemiology* / Q000235:genetics; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013961:Thyroid Gland / Q000473:pathology* / Q000528:radiation effects*