Epigenetics and imprinting of the trophoblast -- a workshop report.
Genomic imprinting is a remarkable process that causes genes to be expressed or repressed depending on their parental-origin. Imprinted genes play important roles in prenatal growth and organ development. Postnatally, imprinted genes can contribute to the regulation of metabolic pathways and behaviour associated with the control of resources. One of the most important sites of imprinted gene action is the placenta. During this workshop at the 11th meeting of the International Federation of Placenta Associations/European Placenta Group held in Glasgow, a series of short talks were presented providing an overview of the evolution, function and mechanisms of imprinting in mammals with particular reference to the placenta. In addition, epigenetic control of trophoblast development and function were considered. This report summarises the contributions to the workshop.
Department of Anatomy, University of Cambridge, Downing St, Cambridge CB2 3DY, UK. afsmith@mole.bio.cam.ac.uk
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Ferguson-Smith
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Moore
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Detmar
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Lewis
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Hemberger
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Jammes
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Kelsey
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Roberts
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Jones
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Constancia
D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease; D018392:Genomic Imprinting; D008322:Mammals / Q000235:genetics; D051379:Mice; D010920:Placenta; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D014327:Trophoblasts