[Effector peptides of the brain renin-angiotensin system in central mechanisms of learned and natural forms of drinking behavior in rats].
Central mechanisms of angiotensin involvement in initiation and realization of operant forms of drinking behavior were investigated. It was suggested that intracerebroventricular microinjection of angiotensin-II and angiotensin-IIl specifically affected the learned forms of drinking behavior. The experiments demonstrated that [des-Asp1]-angiotensin-I produced only the natural forms of drinking behavior. Angiotensins modulated specific forms of thirst-associated behavior such as exploring, grooming, and ingestive behavior. Injections of AT1 receptor antagonist losartan were associated with acute water intake decrease and sharp operant behavior inactivation.
Vlasenko
R Ia
RIa
Kotov
A V
AV
D000803:Angiotensin I / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000805:Angiotensin III / Q000008:administration & dosage / Q000494:pharmacology; D000809:Angiotensins / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D004327:Drinking Behavior / Q000502:physiology*; D007276:Injections, Intraventricular; D007858:Learning; D019808:Losartan / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000502:physiology*; D013894:Thirst
D047228:Angiotensin II Type 1 Receptor Blockers; D000809:Angiotensins; D000804:Angiotensin II; D000805:Angiotensin III; C011437:angiotensin I, des-Asp(1)-; D000803:Angiotensin I; D019808:Losartan