[Thermoprotector properties of a combination of sydnocarb with ladasten].
Thermoprotector properties of a 1 : 1 combination of sydnocarb and ladasten (both in a dose of 10 or 20 mg/kg) along with its effect on the hemodynamics and respiration in experimental animals were studied. The combination of sydnocarb (20 mg/kg) and ladasten (20 mg/kg) produced a significant thermoprotector effect, enhanced the regional and local cerebral flow, and increased the respiration rate.
Levina
M N
MN
Badyshtov
B A
BA
Gan'shina
T S
TS
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004338:Drug Combinations; D004357:Drug Synergism; D018882:Heat Stress Disorders / Q000503:physiopathology / Q000517:prevention & control*; D006439:Hemodynamics / Q000187:drug effects; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D051379:Mice; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013558:Sydnones / Q000008:administration & dosage / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D004338:Drug Combinations; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D020011:Protective Agents; D013558:Sydnones; D000218:Adamantane; C009257:sidnocarb