Synthesis and evaluation of antifungal activity of naphthoquinone derivatives.
3-Arylamino-2-phenylsulfinylnaphthoquinones, 2,3-diarylthio-naphthoquinones and 2-phenylsulfinyl-3-arylthio-1,4-dihydronaphtalenes are synthesized and tested against five fungi. The activities of these products were better than amphotericine B against all the strains except for Candida albicans.
Laboratoire de chimie thérapeutique, université Claude-Bernard, faculté de Pharmacie, 8 avenue Rockefeller, 69373 Lyon cedex 08, France.
Giaccomo
G
Errante
Grazia
G
La Motta
Catarina
C
Lagana
Vierle
V
Wittebolle
Marie-Elisabeth
ME
Sarciron
Roland
R
Barret
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013045:Species Specificity
D000935:Antifungal Agents; D009285:Naphthoquinones