Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.
Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index.
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center-Montefiore Hospital, 3459 Fifth Ave., Pittsburgh, PA 15213, USA. randhawapa@msx.upmc.edu
Parmjeet
P
Randhawa
Noush Afarin
NA
Farasati
Ron
R
Shapiro
Karl Y
KY
Hostetler
D000998:Antiviral Agents / Q000494:pharmacology*; D001739:BK Virus / Q000187:drug effects* / Q000502:physiology; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D004279:DNA, Viral / Q000096:biosynthesis; D004952:Esters / Q000494:pharmacology; D063065:Organophosphonates / Q000493:pharmacokinetics / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004279:DNA, Viral; D004952:Esters; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir