[Complementary treatments of chronic viral hepatitis C].
Pegylated interferon and ribavirin combination therapy represent the standard-of-care treatment for chronic hepatitis C, that allows to cure more than half of the patients. However, the success of this bitherapy is in balance with numerous side effects, especially hematologic and psychiatric. This review is focused on complementary treatments (erythropoietin, G-CSF, vitamin E, glutathion, ursodeoxycholic acid and antidepressants) likely to bring a benefit in maintaining adequate interferon and ribavirin dosages and in improving quality of life. This analysis has been performed by using the Medline(R) data base and with data from laboratories which commercialized these molecules. Erythropoietin, G-CSF and antidepressants are the best tools to optimize the bitherapy in its dose and its duration while privileging the quality of life of HCV-infected patients.
Thevenot
Thierry
T
Service d'Hépatologie et de Soins Intensifs Digestifs, Service d'Hépatologie, Hôpital Universitaire Jean Minjoz, Besançon. tthevenot@chu-besancon.fr
Di Martino
Vincent
V
Lunel-Fabiani
Françoise
F
Vanlemmens
Claire
C
Becker
Marie-Claude
MC
Bronowicki
Jean-Pierre
JP
Bresson-Hadni
Solange
S
Miguet
Jean-Philippe
JP
D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control; D000928:Antidepressive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004921:Erythropoietin / Q000627:therapeutic use; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D009503:Neutropenia / Q000139:chemically induced / Q000517:prevention & control; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control
D000928:Antidepressive Agents; D000975:Antioxidants; D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D004921:Erythropoietin; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a