Sigma L is important for cold shock adaptation of Bacillus subtilis.
Although sigma factor-dependent transcriptional regulation was shown to be essential for adaptation to different environmental stimuli, no such sigma factor has been related to the regulation of the cold shock response in Bacillus subtilis. In this study, we present genetic evidence for participation of sigma(L) (sigma(54)) and the two sigma(L)-dependent transcriptional enhancers BkdR and YplP in the cold shock response of Bacillus subtilis JH642. Single-gene deletion of either sigL, bkdR, or yplP resulted in a cold-sensitive phenotype.
Wiegeshoff
Frank
F
Philipps-Universität Marburg, FB Chemie-Biochemie, Hans-Meerwein-Strasse, D-35032 Marburg, Germany.
Beckering
Carsten L
CL
Debarbouille
Michel
M
Marahiel
Mohamed A
MA
D000222:Adaptation, Physiological / Q000235:genetics*; D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D003080:Cold Temperature; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D008954:Models, Biological; D051877:RNA Polymerase Sigma 54 / Q000235:genetics / Q000502:physiology*
D051877:RNA Polymerase Sigma 54