Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate.
A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.
Wang
Yuqiang
Y
Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. yuqiangwang2001@yahoo.com
Li
Lianfa
L
Jiang
Wei
W
Yang
Zhaoqi
Z
Zhang
Zaijun
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D045744:Cell Line, Tumor; D004281:Docosahexaenoic Acids / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D017239:Paclitaxel / Q000737:chemistry
D000970:Antineoplastic Agents; D004281:Docosahexaenoic Acids; D004317:Doxorubicin; D017239:Paclitaxel