[Effect of chronic ionizing irradiation on the structural properties of the apical and mitochondrial membranes of small intestine enterocytes].
The different ways of the radiation-induced effect were revealed in the investigations of chronic ionizing radiation influence in total doses of 0.3, 0.6 and 1.0 Gy (0.0072 Gy/day) on the structural properties of the apical and of the mitochondrial membranes of small intestine enterocytes. The modification of the physical properties of the membrane surface area, the decrease of the structural order of the lipid component and conformational changes of the proteins were shown to be specific for the apical membrane. The disturbance of the dynamic properties and topography of the internal mitochondria membrane was revealed in the investigation of the inductive-resonance energy transfer between the pairs of the fluorophores: tryptophan-pyrene, tryptophan-ANS, pyrene-ANS.
S V
SV
Khizhniak
E A
EA
Kisil'
E A
EA
Laposha
A G
AG
Kudriavtseva
V M
VM
Voĭtsitskiĭ
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000528:radiation effects / Q000648:ultrastructure; D004735:Energy Transfer / Q000528:radiation effects; D020895:Enterocytes / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D005720:Gamma Rays / Q000009:adverse effects*; D007421:Intestine, Small / Q000166:cytology / Q000528:radiation effects*; D007425:Intracellular Membranes / Q000378:metabolism / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D011829:Radiation Dosage; D051381:Rats; D013997:Time Factors
D008563:Membrane Lipids; D008565:Membrane Proteins