Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice.
As measured by a proportional bactericidal technique in the mouse footpad system, the bactericidal activity against Mycobacterium leprae of R207910 was equal to that of rifapentine, rifampin, or moxifloxacin and significantly greater than those of minocycline, PA-824, and linezolid. These data suggest that R207910 may play an important role in treatment of leprosy.
Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, 91 Boulevard de l'Hôpital, 75634 Paris Cedex 13, France. baohong_ji@yahoo.com
Baohong
B
Ji
Aurélie
A
Chauffour
Koen
K
Andries
Vincent
V
Jarlier
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D064687:Diarylquinolines; D005260:Female; D024841:Fluoroquinolones; D007918:Leprosy / Q000188:drug therapy; D000069349:Linezolid; D051379:Mice; D000077266:Moxifloxacin; D009166:Mycobacterium leprae / Q000187:drug effects*; D009593:Nitroimidazoles / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*
D000081:Acetamides; D000890:Anti-Infective Agents; D001372:Aza Compounds; D064687:Diarylquinolines; D024841:Fluoroquinolones; D009593:Nitroimidazoles; D023303:Oxazolidinones; D011804:Quinolines; C410767:pretomanid; C493870:bedaquiline; D000069349:Linezolid; D000077266:Moxifloxacin