Tolls for B cells.
Priming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventing immune cells from attacking self-antigens. It is well known that signals provided by innate immune receptors, such as Toll-like receptors (TLR), are essential to induce dendritic cell maturation that subsequently allows the priming of naive T cells. In this issue of the European Journal of Immunology, it is shown that TLR stimulation effectively potentiates naive human B cell activation and production of antibodies in T-dependent immune responses. TLR signals can be delivered to B cells directly, or indirectly via cytokines provided by TLR-activated dendritic cells.
Fillatreau
Simon
S
Department for Humoral Immunology & Department for Immune Regulation, German Arthritis Research Centre, Berlin, Germany. fillatreau@drfz.de
Manz
Rudolf A
RA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors