Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand.
[structure: see text] 5'-Deoxy-5'-phenyladenophostin A (5), designed as a useful IP(3) receptor ligand based on the previous structure-activity relationship studies, was successfully synthesized via two key stereoselective glycosidation steps. This compound proved to be a highly potent IP(3) receptor agonist.
Mochizuki
Tetsuya
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Kondo
Yoshihiko
Y
Abe
Hiroshi
H
Taylor
Colin W
CW
Potter
Barry V L
BV
Matsuda
Akira
A
Shuto
Satoshi
S
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000819:agonists*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C515437:5'-deoxy-5'-phenyladenophostin A; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008024:Ligands; D000241:Adenosine