Miniaturised isotachophoresis analysis.
The application of miniaturized total analysis systems (microTAS) has seen rapid development over the past few years. Isotachophoresis (ITP) has been transferred into microchip format for both electrophoretic separation and pretreatment purposes, due to its advantageous features including separation parameters controlled by electrolyte composition and high sample load capacity. The primary focus of this concise review is to summarize the basic features of microchip based ITP and its applications to the analysis and pretreatment of ionic compounds and biomolecules that have arisen since 1998.
Institute for Analytical Sciences, Bunsen-Kirchhoff Str. 11, D-44139 Dortmund, Germany.
Lin
L
Chen
Jeff E
JE
Prest
Peter R
PR
Fielden
Nicholas J
NJ
Goddard
Andreas
A
Manz
Philip J R
PJ
Day
D004247:DNA / Q000032:analysis; D046209:Electrophoresis, Microchip / Q000295:instrumentation / Q000379:methods*; D008904:Miniaturization / Q000295:instrumentation / Q000379:methods; D019904:Polymethyl Methacrylate / Q000737:chemistry
D004247:DNA; D019904:Polymethyl Methacrylate