An overview of synthetic approaches to porphyrin, phthalocyanine, and phenothiazine photosensitizers for photodynamic therapy.
The mechanistic basis of photodynamic therapy is reviewed briefly, and the factors that are important in improving photosensitizers are examined. The methods for preparing the three main classes of PDT photosensitizers, namely, porphyrins, phthalocyanines, and phenothiazines, are reviewed.
Gorman
Stephen A
SA
Department of Colour and Polymer Chemistry, Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds, LS2 9JT, UK. S.A.Gorman@leeds.ac.uk
Brown
Stanley B
SB
Griffiths
John
J
D007211:Indoles / Q000138:chemical synthesis; D054833:Isoindoles; D010640:Phenothiazines / Q000138:chemical synthesis; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis*; D011166:Porphyrins / Q000138:chemical synthesis
D007211:Indoles; D054833:Isoindoles; D010640:Phenothiazines; D017319:Photosensitizing Agents; D011166:Porphyrins; C031637:phenothiazine; C013647:phthalocyanine