Are mouse models of allergic asthma useful for testing novel therapeutics?
Experimental mouse allergic asthma is a reliable, clinically relevant facsimile of human disease. The focus here is to demonstrate that antigen-induced mouse allergic asthma is a useful model for testing novel therapeutics. Furthermore, it is especially crucial to treat mice during established disease, either during ongoing clinically manifest disease or to prevent disease relapses. In addition, our results indicate that lung Th2 resting memory cells are important targets for the treatment of allergic asthma.
Epstein
Michelle M
MM
Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Medical University of Vienna, Lazarettgasse 19, A-1090 Vienna, Austria. Michelle.Epstein@meduniwien.ac.at
D000485:Allergens / Q000276:immunology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D051379:Mice; D013045:Species Specificity
D000485:Allergens; D018927:Anti-Asthmatic Agents