The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes.
The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0118, USA.
Raul
R
Alvarez-Venegas
Monther
M
Sadder
Andrej
A
Hlavacka
Frantisek
F
Baluska
Yuannan
Y
Xia
Guoqing
G
Lu
Alexey
A
Firsov
Gautam
G
Sarath
Hideaki
H
Moriyama
Joseph G
JG
Dubrovsky
Zoya
Z
Avramova
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D011495:Histone-Lysine N-Methyltransferase; D008958:Models, Molecular; D008969:Molecular Sequence Data; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D011487:Protein Conformation; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*
D029681:Arabidopsis Proteins; D018129:Phosphatidylinositol Phosphates; D014157:Transcription Factors; C113567:phosphatidylinositol 5-phosphate; C504056:At2g31650 protein, Arabidopsis; D011495:Histone-Lysine N-Methyltransferase