Interleukin-10 and chronic liver disease.
Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. Numerous investigations suggest that IL-10 plays a major role in chronic liver diseases. IL-10 gene polymorphisms are possibly associated with liver disease susceptibility or severity. Recombinant human IL-10 has been produced and is currently tested in clinical trials. These trials may give new insights into the immunobiology of IL-10 and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target.
Zhang
Li-Juan
LJ
Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China.
Wang
Xiao-Zhong
XZ
D000818:Animals; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000502:physiology*; D008103:Liver Cirrhosis / Q000235:genetics / Q000503:physiopathology; D008107:Liver Diseases / Q000235:genetics / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D018123:Receptors, Interleukin / Q000502:physiology; D053701:Receptors, Interleukin-10
D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D016753:Interleukin-10