Synthesis and reactivity of a 9-membered azaenediyne: importance of proximity effect in N-alkylation.
Synthesis of a 9-membered azaenediyne has been achieved for the first time via intramolecular N-alkylation; the importance of proximity of the reacting centres via cobalt carbonyl complexation of the acetylenic moiety and not the activation of propargylic carbon has been demonstrated.
Bioorganic Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, India.
Sandip Kumar
SK
Roy
Amit
A
Basak
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000478:Alkylation; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D003035:Cobalt / Q000737:chemistry; D003500:Cyclization
D000475:Alkenes; D000480:Alkynes; D001372:Aza Compounds; D001688:Biological Products; D001952:Bridged-Ring Compounds; D003035:Cobalt