Decrease in plasma adiponectin concentrations in patients with variant angina pectoris.
BACKGROUND
Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS). However, the correlation between plasma adiponectin and variant angina pectoris (VAP) has not been verified. Plasma adiponectin concentrations between VAP and other coronary artery diseases was compared in the present study. The association between plasma adiponectin concentration and VAP was also investigated.


RESULTS
Plasma adiponectin concentrations in the VAP group (n=101) were compared with those of the ACS group (n=117), the stable angina pectoris group (n=108), and the normal coronary group (n=81). Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6+/-5.4 vs 5.2+/-4.0 vs 9.0 +/-6.2 microg/ml, p<0.001, respectively). Multivariate analysis indicated that plasma adiponectin (odds ratio (OR) 0.735, 95% confidence interval (CI) 0.621-0.855, p=0.011), smoking (OR 2.012, 95% CI 1.210-3.880, p=0.020), and age (OR 0.976, 95% CI 0.957-0.997, p=0.022) correlated independently with the development of VAP.


CONCLUSIONS
Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.
Hong
Soon Jun
SJ
Department of Cardiology, Cardiovascular Center, Korea University Guro Hospital, Seoul.
Seo
Hong Seog
HS
Rha
Seung Woon
SW
Oh
Dong Joo
DJ
Kwon
Jung Ah
JA
Lee
Kap No
KN
Jang
Yang Soo
YS
Ro
Young Moo
YM
Park
Chang Gyu
CG
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000788:Angina Pectoris, Variant / Q000097:blood*; D016001:Confidence Intervals; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors
D052242:Adiponectin