Preliminary study of responses in mussel (Mytilus edilus) exposed to bisphenol A, diallyl phthalate and tetrabromodiphenyl ether.
Environmental pollutants with hormonal activity including bisphenol, diallyl phtalate and tetrabromodiphenyl ether, have the potential to alter gonadal development and reproduction in aquatic wildlife. Little is known about the biological impact of environmentally relevant concentrations in mussels. To investigate some aspects of their potential estrogenic action, mussels were continuously exposed during 3 weeks. Gonadal development and vitellogenin like protein levels were examined. Bisphenol (50 microg/l) induced the expression of phospho-proteins in females and spawning in both sexes. Diallyl phthalate and tetrabromodiphenyl ether decreased phospho-protein levels in both sexes and induced spawning in males. Moreover, severe damaging effects on ovarian follicles and ovocytes were observed in both bisphenol A- and tetrabromodiphenyl ether-exposed female mussels.
Aarab
N
N
Environmental and Toxicological Chemistry LPTC, UMR CNRS 5472, Toxicology Unit, University Bordeaux 1, Avenue des Facultés, 33405 Talence, France.
Lemaire-Gony
S
S
Unruh
E
E
Hansen
P D
PD
Larsen
B K
BK
Andersen
O K
OK
Narbonne
J F
JF
D000818:Animals; D001559:Benzhydryl Compounds; D004781:Environmental Exposure; D005260:Female; D006066:Gonads / Q000187:drug effects / Q000473:pathology; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D008297:Male; D049880:Mytilus edulis / Q000187:drug effects*; D009865:Oocytes / Q000187:drug effects / Q000473:pathology; D006080:Ovarian Follicle / Q000187:drug effects; D010636:Phenols / Q000633:toxicity*; D010647:Phenyl Ethers / Q000633:toxicity*; D010750:Phosphoproteins / Q000096:biosynthesis / Q000187:drug effects; D010795:Phthalic Acids / Q000633:toxicity*; D011075:Polybrominated Biphenyls; D012098:Reproduction / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated; D010636:Phenols; D010647:Phenyl Ethers; D010750:Phosphoproteins; D010795:Phthalic Acids; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; C511295:2,2',4,4'-tetrabromodiphenyl ether; C049098:diallyl phthalate; C006780:bisphenol A; D000098826:Bisphenol A Compounds