Reversible plasma testosterone levels reduction after gentamicin administration and freund's adjuvant arthritis in rats.
The present study was undertaken in order to investigate the influence of gentamicin on plasma testosterone levels of healthy and with Freund's adjuvant arthritis rats. Gentamicin (40 mg/day for 4 days) induced significant decrease of testosterone levels in comparison with the control group (P<0.025). Intraperitoneal calcium administration (30 mg/ kg bw) prevented gentamicin effect and maintained testosterone levels to that of the control. Decreased testosterone levels were also observed in gentamicin received Freund's adjuvant arthritic rats, in the acute stage of the inflammatory disease (P<0.025), and in the acute stage of Freund's adjuvant arthritis (P<0.001). It is concluded that the administration of gentamicin decreases plasma testosterone levels without any effect on body and seminal vesicles weight. Calcium loading counteracts gentamicin reducing effect on plasma testosterone levels. Freund's adjuvant arthritis influences the function of body and seminal vesicles as it was shown by the reduction of testosterone levels, body and seminal vesicles weight during the acute phase of the inflammatory disease. In any case the effect was reversible.
Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece. xkarag@med.uoa.gr
Hariklia K
HK
Carageorgiou
Constantine A
CA
Stratakis
Peter D
PD
Damoulis
Dennis D
DD
Varonost
Ioanna D
ID
Messari
Antoine Ch
ACh
Sideris
Anastasia P
AP
Sfikakis
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D003864:Depression, Chemical; D005620:Freund's Adjuvant; D005839:Gentamicins / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000097:blood*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D013739:Testosterone; D005620:Freund's Adjuvant; D002118:Calcium