Assessment of serum cystatin C in children with congenital solitary kidney.
The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. The study group (I) consisted of 36 children, 3-21 years of age (median 10.8 years), with a congenital solitary kidney and no other urinary defects. The control group (C) contained 36 healthy children, 5-21 years old (median 10.9 years). Nephelometric methods were used to determine serum cystatin C level, the Jaffe method to assess creatinine concentration and the Schwartz formula to estimate glomerular filtration rate. Kidney length was measured with the patient in a supine position, and overgrowth was estimated (O%) in comparison with the respective kidney in the control group. Serum cystatin C level in group I was higher than that in the control group (P<0.05). Increased values, above 0.95 mg/l, were found in 16/36 (44%) children aged 12-21 years. Glomerular filtration rate (GFR, estimated by the Schwartz formula) and creatinine level in group I were similar to those of the control group (P>0.05). Increased kidney length was found (median 18.2%). Cystatin C concentration was positively correlated with O% (r=0.406, P<0.01) and kidney length to child height ratio (L/H) (r=0.376, P<0.05). We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney.
1st Department of Paediatrics, Medical University of Białystok, ul. Waszyngtona 17, 15-274, Białystok, Poland. annwasil@interia.pl
Anna
A
Wasilewska
Walentyna
W
Zoch-Zwierz
Iwona
I
Jadeszko
Tadeusz
T
Porowski
Anna
A
Biernacka
Alicja
A
Niewiarowska
Agata
A
Korzeniecka-Kozerska
D000222:Adaptation, Physiological / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000254:growth & development; D008297:Male; D009929:Organ Size / Q000502:physiology; D014564:Urogenital Abnormalities / Q000097:blood / Q000503:physiopathology*
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine