Childhood-onset multifocal motor neuropathy with conduction blocks.
Multifocal motor neuropathy (MMN) is an acquired disorder with onset in adulthood. The authors describe a patient with a slowly progressing distal upper limb motor neuropathy since age 6 years, in whom definite conduction blocks in upper limbs, outside common entrapment sites, and no sensory involvement were consistent with MMN. IV immunoglobulin treatment produced marked muscle strength improvement and conduction block disappearance. MMN diagnosis should also be considered in childhood.
Department of Child Neurology, National Neurological Institute C. Besta, Milan, Italy. imoroni@istituto-besta.it
I
I
Moroni
M
M
Bugiani
C
C
Ciano
R
R
Bono
D
D
Pareyson
D017668:Age of Onset; D002648:Child; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009046:Motor Neurons / Q000473:pathology*; D018908:Muscle Weakness / Q000188:drug therapy / Q000473:pathology; D009431:Neural Conduction; D011115:Polyneuropathies / Q000188:drug therapy / Q000473:pathology*
D016756:Immunoglobulins, Intravenous