[Correlations among GDx-variable corneal compension, optical coherence tomography, and Heidelberg retina tomograph and relationships between these structural parameters and visual field indices].
OBJECTIVE
In glaucoma patients, to compare the correlations among parameters measured by Heidelberg Retina Tomography(HRT) and retinal nerve fiber layer thickness (RNFLT) measured by GDx-variable corneal compensation (GDx-VCC) and optical coherence tomography (OCT), and to assess the relationship among these structural parameters, and visual field damage.


METHODS
A unilateral eye of 110 patients with open-angle glaucoma were included in this study. Each individual was analyzed by HRT (version 3.04), GDx-VCC (version 5.3.2), and OCT-1 (version A6 X1). The correlations among these parameters regarding global area, superior sector, and inferior sector were obtained from the 3 instruments and compared. The correlations among the mean deviation (MD) in the Humphrey field analysis and the parameters in global area from the 3 instruments were calculated.


RESULTS
The MD showed quadratic regressions to each global parameter (GDx-VCC; 0.625 (nerve fiber indicator): OCT 0.616 (average RNFLT); HRT, 0.501 (rim area)). Most parameters in OCT and GDx-VCC had highly significant correlations. The rim area showed the highest correlation in each sector to RNFLT with GDx-VCC or OCT among HRT parameters.


CONCLUSIONS
These structural parameters derived from GDx-VCC, OCT and HRT analyses had bilinear correlation to the MD. Retinal nerve fiber loss detected on GDx-VCC and OCT correlated linearly with the neuroretinal rim area measured by HRT. These instruments may be useful in monitoring structural changes in glaucoma.
Kanamori
Akiyasu
A
Department of Organ Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Japan. kanaaki@med.kobe-u.ac.jp
Kusuhara
Azusa
A
Tatsumi
Yasuko
Y
Fujioka
Miyuki
M
Maeda
Hidetaka
H
Nakamura
Makoto
M
Negi
Akira
A
D000328:Adult; D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014794:Visual Fields