[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].
Humanine is a human neuroprotective peptide with a wide action spectrum. To analyze molecular mechanisms of humanin functioning, a search for proteins interacting with this peptide was conducted using yeast two-hybrid system. Screening of human fetal brain cDNA library identified seven proteins with different functions that specifically interacted with humanin.
Maksimov
V V
VV
Arman
I P
IP
Tarantul
V Z
VZ
D003001:Cloning, Molecular / Q000379:methods; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics* / Q000378:metabolism; D018696:Neuroprotective Agents; D011485:Protein Binding / Q000235:genetics; D020798:Two-Hybrid System Techniques
D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018696:Neuroprotective Agents; C427211:humanin