Ginsenoside Re attenuate beta-amyloid and serum-free induced neurotoxicity in PC12 cells.
OBJECTIVE
To study the effect of ginsenoside Re on PC12 cell damage induced by serum deprivation and beta-amyloid peptide.


METHODS
PC 12 cell survival was measured by MTT and lactate dehydrogenase (LDH) assay. Results Serum-free medium and beta-amyloid peptide (10-100 microM) induced cytotoxicity in PC 12 cells. Ginsenoside Re (0.1-100 microM) attenuated the cytotoxic effects of serum-free medium and beta-amyloid peptide (50 microM) in a concentration-dependent manner.


CONCLUSIONS
Ginsenoside Re prevented PC 12 cells from lesion induced by serum-free medium and beta-amyloid peptide.
Ji
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ZN
Department of Oncology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, People's Republic of China. jzning@163.com
Dong
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Ye
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Choi
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Tsim
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D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D016895:Culture Media, Serum-Free; D036145:Ginsenosides / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D005894:Panax / Q000737:chemistry; D051381:Rats
D016229:Amyloid beta-Peptides; D016895:Culture Media, Serum-Free; D036145:Ginsenosides; D018696:Neuroprotective Agents; C049864:ginsenoside Re; D007770:L-Lactate Dehydrogenase