Micro-emultocrit technique: a valuable tool for determination of critical HLB value of emulsions.
The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB) value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25 degrees C and 4 degrees C) and their physicochemical behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems. In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.
Universidade Federal do Rio Grande do Norte - Departamento de Farmácia - Programa de Pós Graduação em Ciências da Saúde - Laboratório de Sistemas Dispersos (LASID) - Natal/RN, Brazil.
Janus P F
JP
Macedo
Leonardo L
LL
Fernandes
Fábio R
FR
Formiga
Michael F
MF
Reis
Toshiyuiky Nagashima
TN
Júnior
Luiz A L
LA
Soares
E Socrates T
ES
Egito
D004355:Drug Stability; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013678:Technology, Pharmaceutical
D004655:Emulsions