Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
The preparation of three different 2-alkoxy-8-hydroxyadenylpeptide conjugates has been accomplished by solid-phase synthesis combined with 'on-resin' Cu(I) catalyzed Huisgen cycloaddition. The immunogenicity of the compounds has been evaluated in IL-12 production and antigen presentation assays.
Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.
Jimmy J
JJ
Weterings
Selina
S
Khan
Gerbrand J
GJ
van der Heden
Jan W
JW
Drijfhout
Cornelis J M
CJ
Melief
Herman S
HS
Overkleeft
Sjoerd H
SH
van der Burg
Ferry
F
Ossendorp
Gijsbert A
GA
van der Marel
Dmitri V
DV
Filippov
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D014612:Vaccines; D018664:Interleukin-12; C002992:8-hydroxyadenine; D000225:Adenine