Physiological role of the putative ammonium transporter RhCG in the mouse.
Ammonium excretion into urine is a major process essential to the regulation of acid-base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene.
Laboratoire de biologie du développement, institut de biologie et de médecine moléculaires, université libre de Bruxelles CP300, rue des professeurs Jeener-et-Brachet, 12, 6041 Gosselies, Belgium.
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S
Biver
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Scohy
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J
Szpirer
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C
Szpirer
B
B
André
A-M
AM
Marini
D000138:Acidosis / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism; D027682:Cation Transport Proteins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D005810:Multigene Family; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D001798:Blood Proteins; D027682:Cation Transport Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D000644:Quaternary Ammonium Compounds; C498523:RHAG protein, human; C413213:RHCG protein, human; D011993:Recombinant Fusion Proteins; C508143:Rh type C glycoprotein, rat; C486033:RhBG protein, mouse; C485880:Rhcg protein, mouse