Phytanic acid, AMACR and prostate cancer risk.
The growing body of knowledge in cancer prevention demonstrates that for many cancers, risk must be defined in terms of both environmental and genetic factors. In prostate cancer, there is increasing evidence linking risk with polymorphisms in the alpha-methylacyl-CoA racemase (AMACR) gene and branched-chain fatty acids derived from specific sources of dietary fats. We are now at the point where we can begin to conceptualize possible inter-relationships between dietary and genetic risk as applied to prostate cancer, with the goal of generating testable hypotheses amenable to coordinated examinations. A greater understanding of such relationships should provide better ways to establish overall risk, to screen for the disease and perhaps to offer specific opportunities for prevention and treatment.
Thornburg
Todd
T
Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Turner
Aubrey R
AR
Chen
Yong Q
YQ
Vitolins
Mara
M
Chang
Baoli
B
Xu
Jianfeng
J
D004032:Diet; D006801:Humans; D008297:Male; D010831:Phytanic Acid / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019998:Racemases and Epimerases / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors
D010831:Phytanic Acid; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase