Low-frequency signal changes reflect differences in functional connectivity between good readers and dyslexics during continuous phoneme mapping.
The current fMRI study investigated correlations of low-frequency signal changes in the left inferior frontal gyrus, right inferior frontal gyrus and cerebellum in 13 adult dyslexic and 10 normal readers to examine functional networks associated with these regions. The extent of these networks to regions associated with phonological processing (frontal gyrus, occipital gyrus, angular gyrus, inferior temporal gyrus, fusiform gyrus, supramarginal gyrus and cerebellum) was compared between good and dyslexic readers. Analysis of correlations in low-frequency range showed that regions known to activate during an "on-off" phoneme-mapping task exhibit synchronous signal changes when the task is administered continuously (without any "off" periods). Results showed that three functional networks, which were defined on the basis of documented structural deficits in dyslexics and included regions associated with phonological processing, differed significantly in spatial extent between good readers and dyslexics. The methodological, theoretical and clinical significance of the findings for advancing fMRI research and knowledge of dyslexia are discussed.
Stanberry
Larissa I
LI
Department of Statistics, University of Washington, Seattle, WA 98195, USA. lstan@u.washington.edu
Richards
Todd L
TL
Berninger
Virginia W
VW
Nandy
Rajesh R
RR
Aylward
Elizabeth H
EH
Maravilla
Kenneth R
KR
Stock
Patricia S
PS
Cordes
Dietmar
D
D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology*; D004410:Dyslexia / Q000503:physiopathology*; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D011932:Reading; D012815:Signal Processing, Computer-Assisted