Oxovanadium(IV) complexes of hydrazides: potential antifungal agents.
Oxovanadium(IV) -derived antifungals have been prepared by condensing equimolar amounts of vanadyl sulfate with hydrazides. All the synthesized ligands and their metal complexes were characterized by IR, UV-Visible and micro analytical data. These synthesized compounds were screened for their antifungal activity against Aspergillus flavus (A. flavus), Trichophyton longifusus (T. longifusus), Candida albicans (C. albicans), Microsporum canis (M. canis), Fusarium solani (F. solani) and Candida glaberata (C. glaberata) fungal strains. All complexes showed promising antifungal activity against different fungal strains with the exception of F. Solani and C. glaberata. Minimum Inhibitory Concentration (MIC) of different complexes and ligands are in the range of 250 to 400 microg/mL. Complex 7a and ligand 13 exhibit lowest MIC of 250 microg/mL whereas, complex 5a and ligands 2, 7 and 14 showed highest MIC of 400 microg/mL.
Maqsood
Zahida T
ZT
Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
Khan
Khalid M
KM
Ashiq
Uzma
U
Jamal
Rifat A
RA
Chohan
Zahid H
ZH
Mahroof-Tahir
Mohammad
M
Supuran
Claudiu T
CT
D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008024:Ligands; D008670:Metals / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D014638:Vanadates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D006834:Hydrazines; D008024:Ligands; D008670:Metals; C075743:oxovanadium IV; D014638:Vanadates