Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia.
BACKGROUND
Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer.


METHODS
To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job-specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents.


RESULTS
In male workers, increased risks were found for linen dust (OR = 3.68, 95% CI 1.00-13.6, adjusted for age, smoking and residence), and unspecified DFs (OR = 1.44, 95% CI 1.07-1.94). Small non-significant excess risks were observed for quartz dust (OR = 1.27; 95% CI 0.83-1.93) and man-made vitreous fibers (MMVFs) (OR = 1.82, 95% CI 0.88-3.75). In female subjects, risks were non-significantly associated with paper dust (OR = 1.77, 95% CI 0.74-4.20), and unspecified DFs (OR = 1.52, 95% CI 0.77-3.03).


CONCLUSIONS
The study showed increased lung cancer risk for selected categories of DFs.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA. andrea.baccarelli@unimi.it
Andrea
A
Baccarelli
Oleg
O
Khmelnitskii
Maria
M
Tretiakova
Sergey
S
Gorbanev
Alexei
A
Lomtev
Irina
I
Klimkina
Vladimir
V
Tchibissov
Olga
O
Averkina
Carol
C
Rice
Mustafa
M
Dosemeci
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D016022:Case-Control Studies; D004391:Dust; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors
D000395:Air Pollutants, Occupational; D004391:Dust