Receptors of mammalian trace amines.
The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. Preliminary in vitro data, obtained using cloned receptors, also suggest a role for TAARs in the function of hallucinogens.
Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC, USA. ahl@rti.org
Anita H
AH
Lewin
D000818:Animals; D001679:Biogenic Amines / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism*; D000095383:Trace Amine-Associated Receptors
D001679:Biogenic Amines; D043562:Receptors, G-Protein-Coupled; D000095383:Trace Amine-Associated Receptors