Optical coherence tomography findings in stage 4A retinopathy of prematurity: a theory for visual variability.
OBJECTIVE
To report macular anatomic abnormalities in eyes with stage 4A retinopathy of prematurity (ROP) that may account for poor visual outcome despite an ophthalmoscopically normal-appearing posterior pole.


METHODS
Retrospective case series.


METHODS
Nine patients (14 eyes).


METHODS
Nine patients (14 eyes) diagnosed with stage 4A retinal detachments were imaged with optical coherence tomography (OCT) before repair by lens-sparing pars plana vitrectomy. One patient (2 eyes) 2 years after successful lens-sparing vitrectomy for stage 4A detachment with reduced visual acuity underwent fluorescein angiography, fundus photography, and imaging with OCT.


METHODS
Optical coherence tomography findings.


RESULTS
Preoperative OCT confirmed absence of macular involvement in 12 of 14 eyes. Two eyes demonstrated diffuse intraretinal posterior pole changes. Both eyes of a 2-year-old infant demonstrated a lack of normal foveal architecture on OCT scanning and an absent foveal avascular zone on angiography.


CONCLUSIONS
Anatomic macular abnormalities--not immediately apparent ophthalmoscopically--may explain the variability in visual outcome after lens-sparing vitrectomy for stage 4A ROP.
Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan, USA.
Mandar M
MM
Joshi
Michael T
MT
Trese
Antonio
A
Capone
D003941:Diagnostic Techniques, Ophthalmological; D005451:Fluorescein Angiography; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008266:Macula Lutea / Q000473:pathology*; D012163:Retinal Detachment / Q000601:surgery; D012178:Retinopathy of Prematurity / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy