Molecular biology of oral cavity squamous cell carcinoma.
Significant advances have been made in understanding the mechanisms that contribute to carcinogenesis in OCSCC. This progress has led to the development of therapeutic strategies that target dysregulated processes in the tumor microenvironment (Fig. 11) [72]. The introduction of angiogenesis inhibitors, growth factor receptor tyrosine kinase inhibitors, and cell cycle regulators into clinical trials for the management of OCSCC has resulted from the great strides made in the understanding of tumor biology. It is important for those caring for patients who have OCSCC to have a firm background in tumor biology, because many future therapies will be based on this complex panorama of cellular physiology.
Department of Head and Neck Surgery, M. D. Anderson Cancer Center of the University of Texas, 1515 Holcombe Boulevard, Unit 441,Houston, TX 77030, USA.
Michael E
ME
Kupferman
Jeffrey N
JN
Myers
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology*; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D008967:Molecular Biology; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology*; D009154:Mutation; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D009857:Oncogenes
D004273:DNA, Neoplasm