[Stability of an oral liquid morphine formulation for pediatric use].
OBJECTIVE
The aim of this study the determination of the stability of an oral morphine hydrochloride solutions.


METHODS
Determinations of a concentrated morphine solution of 4 mg/ml and the impact of two temperatures, 4 degrees C (refrigerator) and 25 degrees C (room) was analyzed via spectrophotometric measurements.


RESULTS
Findings showed the high stability of the solutions at 4 degrees C, since no significant degradation was observed during the 30 days of the study, whereas at room temperature stability losses were hardly seen during the first 7 days, reaching 6.8% +/- 0.5% after 15 days.


CONCLUSIONS
The tested morphine solution is stable at 4 degrees C during 30 days, but not at room temperature.
Morales
M E
ME
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Granada, Sevilla.
Gallardo
V
V
López
G
G
Atienza
M
M
Marín
R
R
Ruiz
M A
MA
D002648:Child; D004355:Drug Stability; D006801:Humans; D009022:Morphine Derivatives; D013696:Temperature
D009022:Morphine Derivatives