Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Mycobacterium tuberculosis and Mycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, in M. tuberculosis and M. smegmatis, and MutT4, in M. smegmatis, have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.
Unité de Génétique Mycobactérienne, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France.
T
T
Dos Vultos
J
J
Blázquez
J
J
Rauzier
I
I
Matic
B
B
Gicquel
D017353:Gene Deletion; D005798:Genes, Bacterial; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D016254:Mutagenesis, Insertional; D009154:Mutation; D020102:Mycobacterium smegmatis / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D009711:Nucleotides / Q000378:metabolism; D011755:Pyrophosphatases / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology*; D000096964:Nudix Hydrolases
D006160:Guanosine Triphosphate; D009711:Nucleotides; D011755:Pyrophosphatases; D000096964:Nudix Hydrolases; C057674:8-hydroxyguanosine triphosphate