[The anti-inflammation effects of Smilax china ethylacetate extract in rats and mice].
OBJECTIVE
To study the anti-inflammations of the ethyl acetate extract of S. china on acute and chronic inflammations.


METHODS
The rat paw edema induced by egg-albumin, the ear edema and the foot edema of mice induced by xylene and formaldehyde, the increased vascular permeability of capillary induced by intraperitoneal injection of 0.7% acetic acid in mice were used to study on the acute, early inflammations and chronic inflammation for the ethyl acetate extract of S. china.


RESULTS
The extract (50-100 g x kg(-1)) could significantly decrease the rat paw edema, and inhibit the ear edema, the increased vascular permeability and the foot edema of mice.


CONCLUSIONS
The ethyl acetate extract of S. china possesses remarkable anti-inflammatory effects on acute inflammation, and also displays anti-inflammatory effects on the chronic inflammation at a certain extent.
Department of Biology & Foodstuff Engineering, Changsha University of Science & Technology, Changsha 410076, China. sxs732@yahoo.com.cn
Xiao-Shuni
XS
Shu
Zhong-Hong
ZH
Gao
Xiang-Liang
XL
Yang
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology*; D002199:Capillary Permeability; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology*; D004487:Edema / Q000378:metabolism / Q000473:pathology*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032281:Smilax / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal