[Effects of Yifuning soft gelatin capsules on pathology and biomechanical indexes of ovariectomied rats].
OBJECTIVE
To study the effects of Yifuning soft gelatin capsules (YFN) on pathology and biomechanical indexes of ovariectomied female rats.


METHODS
Sixty female Sprague-Dawley rats without pregnancy and delivery were used,50 of them were ovariectomized and randomly divided into 5 groups: ovariectomy(OVX), OVX with diethylstilbestrol tables (DT), OVX with YFN (high dose,middle dose and low dose), the others were sham-operated group. The rats began to take the rats drugs in the fifth week after the operation. After 12 weeks of treat ment the rats were killed, and the bones were collected to inspect. The pathology of bone was observed with the HE stain and the area of trabecular was detected. The electronic testing device was used to detect the biomechanical properties.


RESULTS
The results indicated that the rat model of postmenopausal osteoporosis (PMO) was a success. Compared with the model group, after application of the drugs, the observation of HE showed different repairing around trabecular. The biomechanical parameters also increased significantly.


CONCLUSIONS
YFN can effectively prevent the loss of bone in OVX rats and strengthen bone quality, and has a good effect on PMO oostmenopausal osteoporosis.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. denghz@firm.mu.com
Hong-Zhu
HZ
Deng
Lei
L
Liang
Xu-Hui
XH
Zhang
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D002214:Capsules; D030024:Curcuma / Q000737:chemistry; D004338:Drug Combinations; D005260:Female; D005269:Femur / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D009822:Oils, Volatile / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology; D010052:Ovariectomy; D010057:Oviducts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D011898:Ranidae; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D004338:Drug Combinations; D008419:Materia Medica; D009822:Oils, Volatile