Gene frequencies of human platelet antigens in the Macedonian population.
Human platelet antigen (HPA) systems consist of more than 12 bi-allelic antigen polymorphisms. Due to these polymorphisms, platelet-membrane glycoproteins can be recognized as alloantigens or autoantigens and can cause conditions such as fetomaternal alloimmune thrombocytopenia, post-transfusion refractoriness to platelets, and post-transfusion throbocytopenic purpura. The purpose of this study was to investigate the distribution of HPA-1, -2, -3, and -5 in Macedonian population by using the polymerase chain reaction and restriction fragment length polymorphism. The allele frequencies were 0.865 for HPA-1a, 0.135 for HPA-1b, 0.852 for HPA-2a, 0.148 for HPA-2b, 0.578 for HPA-3a, 0.422 for HPA-3b, 0.909 for HPA-5a, and 0.091 for HPA-5b. Results of our study were not significantly different from those reported in the other European studies. Our population displayed the highest frequency for HPA-2b allele (0.148) reported among European population.
Department of Haematology, Faculty of Medicine, University Ss. Kiril and Metodij, Skopje, Republic of Macedonia.
M
M
Pavkovic
A
A
Petlichkovski
A
A
Strezova
T
T
Arsov
D
D
Trajkov
M
M
Spiroski
D000483:Alleles; D016824:Antigens, Human Platelet / Q000145:classification / Q000235:genetics*; D001792:Blood Platelets / Q000276:immunology*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018843:Republic of North Macedonia
D016824:Antigens, Human Platelet