Effects of glyprolines on stress-induced behavioral disorders in rats.
We report here studies on the antistress protective actions of three peptides of the glyproline family: Pro-Gly-Pro, Pro-Gly, and Gly-Pro. Stress (10 min forced swimming) evoked typical changes in the behavioral activity of rats in the elevated cross maze and hole board tests, providing evidence of a significant increase in anxiety and a decrease in the level of orientational-investigative activity. Prior (15 min before stress) i.p. administration of Pro-Gly-Pro and Gly-Pro at a dose of 3.7 microM/kg significantly decreased the stress-induced behavioral abnormalities. This demonstrates the possibility that peptides Pro-Gly-Pro and Gly-Pro may affect CNS structures involved in forming the body's responses to stress-inducing factors. Peptide Pro-Gly, at an equimolar dose, had no marked protective effect and only slightly decreased the stress-induced abnormalities in the behavior of rats.
MV Lomonosov Moscow State University, Vorob'evy Gory, Russia. sagushka@mail.ru
S E
SE
Badmaeva
G N
GN
Kopylova
N N
NN
Abushinova
G E
GE
Samonina
B A
BA
Umarova
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001526:Behavioral Symptoms / Q000188:drug therapy* / Q000209:etiology*; D004151:Dipeptides / Q000737:chemistry / Q000627:therapeutic use*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D013312:Stress, Physiological / Q000150:complications*
D004151:Dipeptides; D018696:Neuroprotective Agents; C015248:glycylproline