Evaluation of Inutec SP1 as a new carrier in the formulation of solid dispersions for poorly soluble drugs.
Solid dispersions made up of itraconazole and Inutec SP1, a new polymeric surfactant, were prepared by spray drying and hot-stage extrusion. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) were used to evaluate the miscibility of the components of the dispersions, and dissolution experiments were performed in simulated gastric fluid without pepsin (SGFsp) to evaluate the pharmaceutical performance of itraconazole from the solid dispersions. DSC analysis showed that the solid dispersions are phase separated systems made up of glassy and crystalline itraconazole and amorphous Inutec SP1. The amount of crystalline drug substance was higher in the dispersions prepared by hot-stage extrusion and was clearly a function of the drug concentration. Since no crystallinity could be detected by XRD points to the fact that the crystallites formed are very small in size. Despite the presence of glassy and crystalline clusters, the dissolution properties of the solid dispersions were significantly improved in comparison to pure itraconazole (glassy or crystalline) or physical mixtures with Inutec SP1. This study proves the potential of the new polymeric surfactant as a carrier in the formulation of solid dispersions for poorly soluble drugs.
Van den Mooter
Guy
G
Laboratorium voor Farmacotechnologie en Biofarmacie, K.U.Leuven, Leuven, Belgium. guy.vandenmooter@pharm.kuleuven.be
Weuts
Ilse
I
De Ridder
Thomas
T
Blaton
Norbert
N
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D017964:Itraconazole / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D014961:X-Ray Diffraction
D004337:Drug Carriers; C514491:Inutec SP1; D011134:Polysaccharides; D017964:Itraconazole