Role of emotionality on inter and intrastrain variations in imipramine response. a comparative study in Balb/c and Swiss mice.
Association between emotionality and effect of imipramine on immobility time in forced swimming test was investigated in Swiss and Balb/c mice. Mice of both the strains were segregated into normal emotional (mean +/- 1SD), low emotional (> mean + 1SD) and high emotional (< mean - 1SD) based on their performance with respect to each indices of emotionality in novel arena and elevated plus maze. Baseline immobility and effect of imipramine (20 mg/kg, po) on immobility time was evaluated in these emotionally different groups of mice using forced swimming test model. Baseline immobility time of low emotional mice was found to be significantly less (P<0.01) and that of high emotional mice was found to be significantly more (P<0.01) when compared to normal emotional mice of both the strains. Immobility time after imipramine administration was found to be significantly less (P<0.05) with low emotional mice and significantly more (P<0.01) with high emotional mice when compared to normal emotional mice of both the strains.
Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore--560 027.
Kshama
K
Devi
P Venugopal
PV
Reddy
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology; D003672:Defecation; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D004777:Environment; D007099:Imipramine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D013045:Species Specificity
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine