Virus fitness: concept, quantification, and application to HIV population dynamics.
Viral fitness has been broadly studied during the past three decades, mainly to test evolutionary models and population theories difficult to analyze and interpret with more complex organisms. More recent studies, however, are focused in the role of fitness on viral transmission, pathogenesis, and drug resistance. Here, we used human immunodeficiency virus (HIV) as one of the most relevant models to evaluate the importance of viral quasispecies and fitness in HIV evolution, population dynamics, disease progression, and potential clinical implications.
Department of Molecular Genetics, Section Virology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue/NN10, Cleveland, OH 44195, USA. quinonm@ccf.org
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Arts
D019380:Anti-HIV Agents / Q000494:pharmacology; D018450:Disease Progression; D024882:Drug Resistance, Viral; D019143:Evolution, Molecular; D014644:Genetic Variation; D006678:HIV / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D009154:Mutation; D014779:Virus Replication
D019380:Anti-HIV Agents