Lipophilicity, antifungal and antioxidant properties of persilben.
The lipophilicity of persilben, an important parameter influencing the penetration of the compound through biological membranes, was determined experimentally by dynamic method and was theoretically calculated according to the fragmentation methods introduced by Crippen, Broto and Viswanadhan. The higher value of partition coefficient (log P = 3.89) obtained for persilben than that for resveratrol points to potentially higher ease of penetration of persilben into cells of living organism. Antimicrobial and antioxidant activities of persilben were tested. The obtained data suggest that this compound possesses some antioxidant activity. Persilben appears to have also some inhibitory effect against some species of dermatophytes from Tnichophyton genus but only at high concentrations.
Katedra i Zakłd Botaniki Farmaceutycznej, Akademia Medyczna, Chodźki 1, 20-093 Lublin.
Helena D
HD
Smolarz
Urszula
U
Kosikowska
Barbara
B
Baraniak
Anna
A
Malm
Andrzej
A
Persona
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006834:Hydrazines / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects / Q000254:growth & development; D000442:Octanols / Q000737:chemistry; D010851:Picrates; D028502:Polygonum / Q000737:chemistry*; D012995:Solubility; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D000442:Octanols; D010851:Picrates; D013267:Stilbenes; C510224:persilben; C004931:1,1-diphenyl-2-picrylhydrazyl