The rationale for advancing the formulation of azelaic acid vehicles.
When first approved in December 2002, 15% azelaic acid (AzA) gel represented a significant advance over the available 20% AzA cream. Although a smaller amount of AzA was present in the new formulation, the gel medium provided a highly effective system for delivering the active ingredient, thus providing more effective treatment. This article explores the nature of these 2 vehicles and highlights the importance of the formulation in which dermatologic drugs are delivered.
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Zoe Diana
ZD
Draelos
D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D019999:Pharmaceutical Solutions / Q000737:chemistry; D012871:Skin Diseases / Q000188:drug therapy*
D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D019999:Pharmaceutical Solutions; C010038:azelaic acid