[Dynamics of Trazodone adsorption on the surface of erythrocytes].
The pharmacokinetics and pharmacodynamics of Trazodone were investigated by HPLC chromatography in the blood plasma and in the erythrocyte supernatant. Two groups of samples (plasma and supernatant) were monitored. The drug was administered to adult dogs and the blood samples were collected for further analysis following 10, 20, 60 min. and 4.0; 6.0 and 8.0 hours since the injection. Metabolism of dopamine and homovanilic acid is closely dependent on the pharmacokinetic of Trazodone. Concentration of homovanilic acid in the blood and supernatant is synchronized with the course of pharmacokinetics of psychotropic preparation. Pharmacokinetic and pharmacodynamic approaches were used in the experiments. Effective action of psychotropic drugs is impossible without extensive knowledge of their pharmacokinetics and pharmacodynamics. They are concerned with the need to determine concentration in body fluids. Experimental study was performed in the adult dogs. Adsorption dynamics of trazodone on the surface of erythrocytes was studied and comparison of the obtained data with the character of pharmacokinetics of tradozone in plasma was performed.
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Zurabashvili
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D000818:Animals; D004285:Dogs; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D007267:Injections; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D014196:Trazodone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone