An autopsy case of primary mixed choriocarcinoma and mature teratoma located in the thymic region associated with elevated human chorionic gonadotropin levels and characteristic testicular changes.
An autopsy case of a 19-year-old male Japanese student with a primary mixed choriocarcinoma and mature teratoma in the thymic region is reported. The patient died 7 days after he first noticed fever and dyspnea. On autopsy, an anterior mediastinal mass was found to be in contact with the thymic gland. The mass weighed 270 g and measured 12.5 cm x 10 cm x 5 cm. The left thoracic cavity contained 2200 ml bloody pleural effusion and 200 g coagula due to hemorrhage from the tumor. Metastasized choriocarcinoma was seen in both lungs and the liver. High serum levels of human chorionic gonadotropin (HCG, 1 634 000 mIU/ml) and a decreased weight of the testes (2.0 g each) with Leydig cell hyperplasia/hypertrophy and the seminiferous tubules with hyaline ghost tubules or Sertoli cell only tubules were seen; other male reproductive organs were histologically normal. Although the serum testosterone level was within the normal range (5.75 ng/ml), luteinizing hormone (LH, 0.1 mIU/ml) and follicle-stimulating hormone (FSH, 0.3 mIU/ml) levels were decreased. High serum levels of HCG and characteristic testicular changes are drscribed.
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, Japan.
Takashi
T
Yuri
Naoto
N
Shimano
Yasuhiro
Y
Ohashi
Katsuaki
K
Miki
Reiko
R
Tsukamoto
Airo
A
Tsubura
D000328:Adult; D001344:Autopsy; D002272:Carcinoembryonic Antigen / Q000097:blood; D002822:Choriocarcinoma / Q000097:blood / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000097:blood*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000473:pathology*; D013724:Teratoma / Q000097:blood / Q000473:pathology*; D013737:Testis / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000378:metabolism
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins