New natural urease inhibitors from Ranunculus repens.
Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of Ranunculus repens led to the isolation of methyl 3,4,5-trihydroxybenzoate 1, R(+)- 4-methoxydalbergione 2 and R(+)-dalbergiophenol 3. The structures of these compounds were established through spectral studies including 1D and 2D NMR experiments and by comparison with literature data. These compounds showed potent inhibitory activity against urease.
Department of Chemistry, Gomal University, D I Khan, Pakistan.
Wahib Noor
WN
Khan
Muhammad Arif
MA
Lodhi
Irshad
I
Ali
Azhar-Ul-Haq
Abdul
A
Malik
Salma
S
Bilal
Rukhsana
R
Gul
Muhammad Iqbal
MI
Choudhary
D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D031947:Ranunculus / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors*
D001565:Benzoates; D004791:Enzyme Inhibitors; D010636:Phenols; D010936:Plant Extracts; C408678:methyl 3,4,5-triacetoxybenzoate; D014510:Urease