Ultrasound promoted regioselective nitration of phenols using dilute nitric acid in the presence of phase transfer catalyst.
Phenols are selectively nitrated to o-nitrophenol along with rate enhancement using dilute nitric acid (6 wt%)/tetra butyl ammonium bromide (TBAB) under sonication. The selectivity can also be reversed to p-nitrophenol using NaBr as a catalyst. Kinetic analysis of nitration of phenol both with and without sonication has been investigated by variation of reaction parameters such as catalyst, nitric acid and substrate concentration.
Nandurkar
Nitin S
NS
Department of Chemistry, Institute of Chemical Technology, Mumbai University, N. Parekh Marg, Matunga, Mumbai 400 019, India.
Bhanushali
Mayur J
MJ
Jagtap
Sachin R
SR
Bhanage
Bhalchandra M
BM
D002384:Catalysis; D007700:Kinetics; D009566:Nitrates / Q000737:chemistry* / Q000528:radiation effects; D017942:Nitric Acid / Q000737:chemistry* / Q000528:radiation effects*; D044367:Phase Transition; D010636:Phenols / Q000737:chemistry* / Q000528:radiation effects; D013010:Sonication
D009566:Nitrates; D010636:Phenols; D017942:Nitric Acid