[Intestinal side effects of COX-2 inhibitors].
COX-2 inhibitors and NSAIDs have similar analgesic, anti-inflammatory and severe upper intestinal side effects. Adding to the sparse and casuistic reports, a further five cases of severe lower intestinal illness associated with COX-2 inhibitor ingestion are presented. Diarrhoea due to microscopic colitis was associated with short-time ingestion of refecoxib and celecoxib by two patients. Refecoxib intake for two months was associated with spontaneous perforation of a well-functioning J-pouch in a patient with ulcerative colitis. Intake of celecoxib and etodolac was associated with colonic ulceration and stricture. Side effects related to COX-2 inhibitors are similar to those related to NSAIDs.
Medicinsk Afdeling, Roskilde Amts Sygehus Køge, DK-4600 Køge. rklkm@ra.dk.
Nadia
N
Calvo
Esben
E
Iversen
Lars Kristian
LK
Munck
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D003108:Colonic Diseases / Q000139:chemically induced*; D039021:Colonic Pouches; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced*; D017308:Etodolac / Q000009:adverse effects; D005260:Female; D006801:Humans; D007081:Ileostomy; D007415:Intestinal Obstruction / Q000139:chemically induced; D007416:Intestinal Perforation / Q000139:chemically induced; D007783:Lactones / Q000009:adverse effects; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects; D012810:Sigmoid Diseases / Q000139:chemically induced; D013449:Sulfonamides / Q000009:adverse effects; D013450:Sulfones / Q000009:adverse effects; D014456:Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; D017308:Etodolac; D000068579:Celecoxib