Defining and maintaining a high quality screening collection: the GSK experience.
Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. This article outlines how this issue was approached at GlaxoSmithKline and some of the hurdles that needed to be overcome to achieve success. The article focuses specifically on the necessary software and hardware infrastructure needed, and at some of the extra benefits of such a project in terms of data mining and data modelling.
Lane
Stephen J
SJ
CASS, DR, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK. stephen.j.lane@gsk.com
Eggleston
Drake S
DS
Brinded
Keith A
KA
Hollerton
John C
JC
Taylor
Nicholas L
NL
Readshaw
Simon A
SA
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000458:organization & administration; D003201:Computers; D004345:Drug Industry / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011786:Quality Control; D012984:Software