Hyperthermic syndromes induced by toxins.
Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems result in heat generation by uncoupling of oxidative phosphorylation, combined with impaired heat dissipation through vasoconstriction. In this article, the authors discuss serotonin and sympathomimetic syndromes, neuroleptic malignant syndrome,and malignant hyperthermia and how these syndromes affect the hypothalamic and sympathetic nervous systems, resulting at times in severe hyperthermia. Current treatment recommendations and future trends in treatment are also discussed.
Rusyniak
Daniel E
DE
Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. drusynia@iupui.edu
Sprague
Jon E
JE
D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology; D012701:Serotonin / Q000506:poisoning; D022722:Thermogenesis / Q000187:drug effects*; D015262:Xenobiotics / Q000506:poisoning*
D015262:Xenobiotics; D012701:Serotonin