[Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].
5FU is one of the most frequently used antioncogenic and cytostatic drug in digestive oncology. It may cause severe adverse events, such as encephalopathy, possibly based on hyperammoniemia, and may lead to coma. We report here the case of a coma with a favorable outcome following 5FU chemotherapy. As any other etiologic findings came to light, hyperammoniemia was discussed as a credible cause.
Service d'Hépato-Gastroentérologie, CH de la région d'Annecy, Annecy. fheluwaert@chu-grenoble.fr
Frédéric
F
Heluwaert
Charles
C
Santre
Claude
C
Martin
Marie-Noëlle
MN
Hilleret
Denis
D
Martin
D000230:Adenocarcinoma / Q000188:drug therapy*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002430:Cecal Neoplasms / Q000188:drug therapy*; D002432:Cecum / Q000473:pathology; D003128:Coma / Q000139:chemically induced* / Q000628:therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D022124:Hyperammonemia / Q000175:diagnosis; D008297:Male; D008875:Middle Aged
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil