Stevens-Johnson syndrome associated with intravenous acetazolamide administration for evaluation of cerebrovascular reactivity. Case report.
A 62-year-old man with left middle cerebral artery stenosis manifesting as transient ischemic attack underwent evaluation of regional cerebrovascular reactivity to acetazolamide using single photon emission computed tomography. Three days after intravenous administration of acetazolamide, erythematous eruptions of various sizes appeared on his back and spread over almost his entire body. Subsequently, painful ulcerations developed on his lips, and oral and nasal mucosa, and the conjunctiva became hyperemic, indicating Stevens-Johnson syndrome. The results of the lymphocyte transformation test were positive to only acetazolamide. Stevens-Johnson syndrome, also known as erythema multiforme major, can be life-threatening, and may be induced by intravenous administration of acetazolamide.
Department of Neurosurgery, Iwate Medical University, Morioka, Iwate. kuogasa@iwate-med.ac.jp
Kuniaki
K
Ogasawara
Nobuhiko
N
Tomitsuka
Masakazu
M
Kobayashi
Nobukazu
N
Komoribayashi
Takeshi
T
Fukuda
Hideo
H
Saitoh
Takashi
T
Inoue
Akira
A
Ogawa
D000086:Acetazolamide / Q000008:administration & dosage / Q000009:adverse effects*; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide