Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.
In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN1/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial activities against Gram-positive and Gram-negative bacteria.
Gorajana
Adinarayana
A
School of Pharmacy, International Medical University, Sesama Center, Plaza, Komanwel, Bukit jalil, 57000 Kuala Lumpur, Malaysia. glknarayana@yahoo.com
Venkatesan
M
M
Vinjamuri
Saisha
S
Kurada
Bapiraju V V S N
BV
Peela
Sujatha
S
Jangam
Premkumar
P
Poluri
Ellaiah
E
Zeeck
Axel
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*; D001580:Benzopyrenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D002845:Chromatography; D019015:Geologic Sediments / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000502:physiology
D000900:Anti-Bacterial Agents; D001580:Benzopyrenes; C012531:resistoflavin