Synthesis and biological action of 1-aminomethyl derivatives of 3-R-4-phenyl-delta2-1,2,4-triazoline-5-thione.
4-Phenyl-1,2,4-triazoline-5-thione [I] and 4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione [II] were subjected to the reaction of aminomethylation with piperazine derivatives. Compounds [III] and [IX] were screened for their antibacterial activities.
Pitucha
Monika
M
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, 6 Staszica Str., 20-081 Lublin, Poland. monika.wujec@am.lublin.pl
Wujec
Monika
M
Dobosz
Maria
M
Kosikowska
Urszula
U
Malm
Anna
A
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000588:Amines; D000900:Anti-Bacterial Agents; D014230:Triazoles