Magnesium absorption from mineral waters of different magnesium content in healthy subjects.
OBJECTIVE
To assess the absorption of magnesium (Mg) from mineral waters of different Mg content in comparison to low mineralized water and a Mg capsule.


METHODS



METHODS
Randomized, controlled, double- blind trial in a crossover design with an additional control with a Mg capsule.


METHODS
Institute of Balneology and Medical Climatology, Medical School of Hanover, Germany.


METHODS
22 healthy male volunteers aged between 23-46 years.


METHODS
After a standardized breakfast, each participant received, in Latin square order, 500 ml of either of two Mg-rich mineral waters (281 or 120 mg/l). As a control condition, a mineral water of low Mg content (8 mg/l) was used. A Mg capsule (Magnesium-Diasporal 150, Protina, Ismaning, Germany) was used for further comparisons.


RESULTS
Changes in serum Mg levels in the first 4 hours after intake differed significantly between the groups (p = 0.030; ANOVA). Mean values differed between the Mg-rich mineral water conditions and the control conditions though did not reach statistical significance (p = 0.055), however, mean values did not differ between the test waters and the capsule (p = 0.338).


CONCLUSIONS
Magnesium from mineral waters can easily be absorbed and its absorption rate is similar to that from a pharmaceutical Mg preparation.
Karagülle
Oguz
O
Institute of Balneology and Medical Climatology, Medical School of Hanover, Germany. karagulle@gmx.com.tr
Kleczka
Thomas
T
Vidal
Christian
C
Candir
Fatma
F
Gundermann
Gisela
G
Külpmann
Wolf Rüdiger
WR
Gehrke
Axel
A
Gutenbrunner
Christoph
C
D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters
D008900:Mineral Waters; D008274:Magnesium