[Effects of different concentration extract from shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice].
OBJECTIVE
To investigate the effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice.


METHODS
Medlab/4 s vital signal recorder was used to measure the effects of extract from Shenghua decoction (3-12 mg x mL(-1)) on contractile amplitude and frequency of the isolated uterus from normal, estrogen-treated and postpartum mice.


RESULTS
Shenghua decoction extract (3-12 mg x mL(-1)) significantly decreased the contractile activity of the mouse isolated uterus in normal non-pregnancy and postpartum, but significantly increased that of the mouse isolated uterus treated with estrogen, and didn't show significant concentration-response relationship.


CONCLUSIONS
The effects of Shenghua decoction extract on contractile activity of mouse-isolated uterus treated with estrogen cannot represent the pharmacological effects on that of in normal non-pregnancy and postpartum uterus.
Zhao
Ding
D
School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China. zhoadingd@163.com
Zhan
Wen-Hong
WH
Li
Lian-Huai
LH
Nie
Feng-Zhi
FZ
Jiao
Jun-Jie
JJ
Lu
Yang
Y
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D049590:Postpartum Period; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004967:Estrogens