Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a 2-year follow-up.
BACKGROUND
The aim of this clinical study was to evaluate the association of locally delivered doxycycline 10% with scaling and root planing in the periodontal treatment of smokers during a 2-year period.


METHODS
Forty-eight chronic periodontitis patients, presenting a minimum of four pockets (>or=5 mm) that bled on probing on anterior teeth were included. Patients were randomly assigned to receive one of the following treatments: scaling and root planing (SRP) and scaling and root planing followed by local application of doxycycline (SRP-D). Assigned treatments were performed at baseline and at 12 months. Clinical parameters, including probing depth (PD) and relative attachment level (RAL), were recorded at baseline; 45 days; 3, 6, and 12 months (retreatment); 45 days following retreatment; and at 15, 18, and 24 months.


RESULTS
In initially deep pockets (>or=7 mm), SRP-D showed greater PD reduction than SRP at 6 and 18 months (mean difference between groups of 1.18 and 1.73 mm, respectively; P <0.05) and greater RAL gain in all periods after 3 months (mean difference between groups of 1.16, 1.99, and 1.78 mm, at 6, 18, and 24 months, respectively; P <0.05). Also, the proportion of sites showing >or=2 mm PD reduction was greater for SRP-D at 6 months (81.2% x 50.8%; P <0.001) and at 24 months (65.5% x 46.5%; P = 0.01). As for RAL gain, this proportion was 34.4% and 18.1% for SRP-D and SRP at 24 months, respectively (P = 0.008).


CONCLUSIONS
The use of locally delivered doxycycline may constitute an important adjunct for the active and supportive treatments of severe periodontal disease in smokers.
Machion
Luciana
L
Department of Periodontics and Prosthodontics, School of Dentistry at Piracicaba, State University of Campinas, São Paulo, Brazil.
Andia
Denise Carleto
DC
Lecio
Giovana
G
Nociti
Francisco Humberto
FH
Casati
Márcio Zaffalon
MZ
Sallum
Antonio Wilson
AW
Sallum
Enilson Antonio
EA
D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000188:drug therapy; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000188:drug therapy; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy*; D011446:Prospective Studies; D016037:Single-Blind Method; D012907:Smoking
D000891:Anti-Infective Agents, Local; D004318:Doxycycline