Increasingly irritable and close to tears: TRPA1 in inflammatory pain.
TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.
McMahon
Stephen B
SB
London Pain Consortium, King's College London, London WC2R 2LS, United Kingdom. stephen.mcmahon@kcl.ac.uk
Wood
John N
JN
D000818:Animals; D007249:Inflammation; D051379:Mice; D018345:Mice, Knockout; D010146:Pain; D000074025:TRPA1 Cation Channel; D013665:Tear Gases / Q000633:toxicity*; D013823:Thermoreceptors / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000187:drug effects* / Q000502:physiology*
D000074025:TRPA1 Cation Channel; D013665:Tear Gases; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse