Probabilistic assessment of the cumulative acute exposure to organophosphorus and carbamate insecticides in the Brazilian diet.
In the present study, the cumulative exposure of 25 acetylcholinesterase (AChE) inhibiting pesticides through the consumption of nine fruits and vegetables by the Brazilian population was assessed. Food consumption data were obtained from a household budget survey conducted in all Brazilian states from July 2002 to June 2003. Residue data from 4001 samples were obtained from the Brazilian national monitoring program on pesticide residues. Relative potency factors (RPF) were calculated with methamidophos or acephate as index compounds (IC), using BMD(10) or NOAEL for AChE inhibition, mostly in rat brain, obtained from national and international pesticide evaluations. Monocrotophos and triazophos, in addition to aldicarb, had the highest calculated RPF in any scenario. The exposure to AChE inhibiting pesticides for the general population at P99.9, represented 33.6% of the ARfD as methamidophos and 70.2% ARfD as acephate. The exposure calculated as acephate could exceed the ARfD at the upper bound of the 95% confidence interval for this percentile. Exposure for children aged up to 6 years were, on average, 2.4 times higher than the exposure for the general population. Tomato represented about 67% of the total intake of AChE inhibiting pesticides. The highest calculated equivalent residues in tomato, which drove most of the estimated intakes at the high percentiles, were related to the illegal use of monocrotophos and triazophos in this crop.
Department of Pharmaceutical Sciences, College of Health Sciences, University of Brasília, 70919-970 Brasília, DF, Brazil. eloisa@unb.br
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D000328:Adult; D001938:Brazil; D002219:Carbamates / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002800:Cholinesterase Inhibitors / Q000032:analysis; D004032:Diet; D004784:Environmental Monitoring / Q000706:statistics & numerical data; D005260:Female; D005506:Food Contamination; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007306:Insecticides / Q000032:analysis; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D009010:Monte Carlo Method; D009943:Organophosphorus Compounds / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D018570:Risk Assessment; D014675:Vegetables / Q000737:chemistry*
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D010573:Pesticide Residues