Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension.
Chlorogenic acid, a polyphenol found in coffee, has antihypertensive actions, but epidemiologic data on the effects of coffee on blood pressure are controversial. Specific coffee components that inhibit the hypotensive effect of chlorogenic acid and the physiologic mechanisms underlying the effects of coffee without these components were investigated. One component, hydroxyhydroquinone (HHQ), inhibited the hypotensive effects of chlorogenic acid in spontaneously hypertensive rats (SHR). The attenuation of hypertension by HHQ-free coffee was associated with nitric oxide, the suppression of mRNA expression of NAD(P)H oxidase, and the improvement in endothelium-dependent vasodilation in the aorta. Thus, HHQ-free coffee might regulate vascular tone by improving the bioavailability of nitric oxide in SHR.
Biological Science Laboratories, Kao Corporation, 2606 Akabane Ichikai-machi, Tochigi 321-3497, Japan. suzuki.atsushi2@kao.co.jp
Atsushi
A
Suzuki
Akihiko
A
Fujii
Naoki
N
Yamamoto
Masaki
M
Yamamoto
Hideo
H
Ohminami
Akiyo
A
Kameyama
Yusuke
Y
Shibuya
Yoshinori
Y
Nishizawa
Ichiro
I
Tokimitsu
Ikuo
I
Saito
D000818:Animals; D001011:Aorta / Q000201:enzymology; D002726:Chlorogenic Acid / Q000008:administration & dosage* / Q000737:chemistry; D003069:Coffee / Q000009:adverse effects / Q000737:chemistry; D004730:Endothelium, Vascular / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006873:Hydroquinones / Q000009:adverse effects / Q000737:chemistry; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008957:Models, Genetic; D019255:NADPH Oxidases / Q000096:biosynthesis; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D014664:Vasodilation / Q000187:drug effects
D003069:Coffee; D006873:Hydroquinones; C013038:hydroxyhydroquinone; D002726:Chlorogenic Acid; D009569:Nitric Oxide; D019255:NADPH Oxidases