Spectrophotometric determination of carbinoxamine maleate in pharmaceutical formulations by ternary complex formation with Cu(II) and eosin.
A simple and sensitive spectrophotometric method was developed for the determination of carbinoxamine maleate in pharmaceutical formulations. The method is based on the formation of a ternary complex, extractable with chloroform, between copper(II), eosin, and carbinoxamine maleate. The absorption spectra of the ternary complexes shows, under optimum conditions, a maxima at 538 nm, with apparent molar absorptive 6.1690 x 10(4) mol(-1) cm(-1), Sandell's sensitives 6.75 x 10(-3) microg cm(-2), and linearity in the concentration range 0.75-10.0 microg ml(-1). The method can be achieved with high accuracy (recovery values, 100 +/- 2%) and precision (with standard deviation 0.029-0.155 and relative standard deviation 3.87-1.55%). The method was again successfully applied, with high accuracy and good precision, for the determination of carbinoxamine maleate in various pharmaceutical formulations (syrup, drops, and tablets).
Department of Chemistry, Faculty of Science, Aleppo University, Syria.
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Ramadan
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Mandil
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D004339:Drug Compounding; D004801:Eosine Yellowish-(YS) / Q000737:chemistry*; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011725:Pyridines / Q000032:analysis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods*; D013454:Sulfoxides
D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011725:Pyridines; D013454:Sulfoxides; D003300:Copper; C004649:carbinoxamine; D004801:Eosine Yellowish-(YS)