Possible peripheral markers for chronic aluminium toxicity in Wistar rats.
This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome oxidase (CO), the terminal enzyme of the electron transport chain, was significantly diminished and that of glucose-6-phosphate dehydrogenase (G-6-PD) was significantly enhanced. Neuromuscular co-ordination was assessed using motor and memory function tests. Deficits were observed suggesting a probable model for chronic Al neurotoxicity.
Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Amarpreet
A
Kaur
Kiran Dip
KD
Gill
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015415:Biomarkers / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D003576:Electron Transport Complex IV / Q000097:blood; D004785:Environmental Pollutants / Q000633:toxicity*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D008297:Male; D020258:Neurotoxicity Syndromes / Q000097:blood / Q000201:enzymology / Q000209:etiology*; D004856:Postural Balance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D036401:Toxicity Tests, Chronic
D015415:Biomarkers; D004785:Environmental Pollutants; D000535:Aluminum; D005954:Glucosephosphate Dehydrogenase; D003576:Electron Transport Complex IV; D002802:Cholinesterases