Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript.
A 54 year old man developed an unusual lipoma in the patellar tendon, consisting of a fibro-adipose component and a chondro-osseous component. The fibro-adipose component contained mature adipocytes, lipoblasts, and fibroblasts; the chondro-osseous component showed typical endochondral bone formation. Molecular analysis showed that the identical HMGA2-LPP fusion transcript-characteristic of lipoma, parosteal lipoma, and pulmonary chondroid hamartoma-was detectable in the both components.
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. ymatsui@sb4.so-net.ne.jp
Y
Y
Matsui
T
T
Hasegawa
T
T
Kubo
T
T
Goto
K
K
Yukata
K
K
Endo
Y
Y
Bando
N
N
Yasui
D050156:Adipogenesis; D002454:Cell Differentiation; D020219:Chondrogenesis; D005355:Fibrosis; D015972:Gene Expression Regulation, Neoplastic; D024003:HMGA Proteins / Q000032:analysis*; D006801:Humans; D007719:Knee Joint; D008067:Lipoma / Q000737:chemistry* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000032:analysis*; D012983:Soft Tissue Neoplasms / Q000737:chemistry* / Q000473:pathology; D013194:Staining and Labeling; D013710:Tendons
D024003:HMGA Proteins; C502535:HMGA2-LPP fusion protein, human; D015514:Oncogene Proteins, Fusion