Analysis of the qualitative dermatoglyphics of the digito-palmar complex in patients with primary open angle glaucoma.
The primary open-angle glaucomas are a group of diseases that have in common characteristic morphological changes at the optic nerve head and retinal nerve fiber layer, progressive retinal ganglion cells death and characteristic visual field loss. The risk for primary open angle glaucoma rises continuously with the level of the intraocular pressure. The disease advances slowly and there are no symptoms. Primary open angle glaucoma is caused by abnormal aqueous humour outflow in the trabecular meshwork in the open angle. Etiopathogenesis of primary open angle glaucoma is unclear. The increased risk of glaucoma in relatives has long been recognized. Frequency for manifestation of the disease is 10-30% in family members. The discovery of the specific gene loci responsible for the manifestation of glaucoma has helped us to understand its mechanism of origin and definitely confirmed the hereditary nature of this disease. Digito-palmar dermatoglyphs were already used to determine hereditary base of many diseases and it was the reason for investigation of their qualitative patterns in patients with glaucoma (22 males and 23 females), their immediate relatives (19 males and 23 females) in comparison to a group of phenotypically healthy population (52 males and 56 females). The results pointed a connection with the dermatoglyphic traits of the digito-palmar complex between patients with glaucoma and their immediate relatives. There is a possible discrimination of patients and their immediate relatives from phenotypically healthy population, too.
Novak-Laus
Katia
K
Department of Ophthalmology, University Hospital "Sestre milosrdnice", Zagreb, Croatia. katiane@net4u.hr
Milicić
Jasna
J
Tedeschi-Reiner
Eugenia
E
Iveković
Renata
R
Korsić
Jadranka
J
Zrinsćak
Ognjen
O
Mandić
Zdravko
Z
D016022:Case-Control Studies; D003878:Dermatoglyphics; D005190:Family; D005260:Female; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008297:Male