title: A generic minimization random allocation and blinding system on web.
abstract: BACKGROUND
  Minimization is a dynamic randomization method for clinical trials. Although recommended by many researchers, the utilization of minimization has been seldom reported in randomized trials mainly because of the controversy surrounding the validity of conventional analyses and its complexity in implementation. However, both the statistical and clinical validity of minimization were demonstrated in recent studies. Minimization random allocation system integrated with blinding function that could facilitate the implementation of this method in general clinical trials has not been reported. SYSTEM OVERVIEW: The system is a web-based random allocation system using Pocock and Simon minimization method. It also supports multiple treatment arms within a trial, multiple simultaneous trials, and blinding without further programming.
  
  
  METHODS
  This system was constructed with generic database schema design method, Pocock and Simon minimization method and blinding method. It was coded with Microsoft Visual Basic and Active Server Pages (ASP) programming languages. And all dataset were managed with a Microsoft SQL Server database. Some critical programming codes were also provided. SIMULATIONS AND RESULTS: Two clinical trials were simulated simultaneously to test the system's applicability. Not only balanced groups but also blinded allocation results were achieved in both trials.
  
  
  CONCLUSIONS
  Practical considerations for minimization method, the benefits, general applicability and drawbacks of the technique implemented in this system are discussed. Promising features of the proposed system are also summarized.
authors.affiliation: Network Center, Fourth Military Medical University, No. 17 Changle West Road, Xi'an, Shaanxi 710032, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Cai
authors.forename: Jielai
authors.initials: J
authors.lastname: Xia
authors.forename: Dezhong
authors.initials: D
authors.lastname: Xu
authors.forename: Donghuai
authors.initials: D
authors.lastname: Gao
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yan
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D020407:Internet; D015233:Models, Statistical; D015337:Multicenter Studies as Topic; D011381:Programming Languages; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012494:Sampling Studies; D016037:Single-Blind Method; D012984:Software; D012985:Software Design