title: Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
abstract: We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
authors.affiliation: Molecular Imaging Program (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
authors.forename: Dong-Woon
authors.initials: DW
authors.lastname: Shin
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Olivier
authors.initials: O
authors.lastname: Gheysens
authors.forename: Qizhen
authors.initials: Q
authors.lastname: Cao
authors.forename: Shan X
authors.initials: SX
authors.lastname: Wang
authors.forename: Sanjiv S
authors.initials: SS
authors.lastname: Gambhir
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000138:chemical synthesis; D005909:Glioblastoma / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D009842:Oligopeptides / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D045663:Quantum Dots; D013055:Spectrophotometry, Infrared / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D020099:Coated Materials, Biocompatible; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid