An efficient enantioselective approach to cyclic beta-amino acid derivatives via olefin metathesis reactions.
The asymmetric synthesis of polyfunctionalized piperidine- and pyrrolidine-based scaffolds, specifically designed for the preparation of cyclic, conformationally constrained beta-amino acids, is realized combining a biocatalytic access to a versatile chiral building block with a wide range of transformations based on olefin metathesis.
Lesma
Giordano
G
Dipartimento di Chimica Organica e Industriale e Centro Interdisciplinare Studi biomolecolari e applicazioni Industriali, Università degli Studi di Milano, via G. Venezian 21, 20133 Milano, Italy.
Danieli
Bruno
B
Sacchetti
Alessandro
A
Silvani
Alessandra
A
D000475:Alkenes / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D000598:Amino Acids, Cyclic