Pitfalls in lactate measurements at 3T.
In clinical MR spectroscopy at higher field strengths, lactate may show reduced or absent signal intensity at an echo time of 144 ms. Although this false-negative result may be predicted from theory, experimental verification and clinical impact have not been fully established. Using scanners from 3 major vendors, spectra from phantoms and patients demonstrate the lactate signal loss and potential error in interpretation. Strategies are discussed to overcome, or at least alleviate, this problem.
Lange
T
T
Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
Dydak
U
U
Roberts
T P L
TP
Rowley
H A
HA
Bjeljac
M
M
Boesiger
P
P
D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism*; D005188:False Negative Reactions; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging
D019344:Lactic Acid