Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.
Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome. It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome. We present a case of hypereosinophilia related to zafirlukast therapy. The patient did not fulfil criteria for Churg-Strauss syndrome. Symptoms and laboratory findings improved after zafirlukast was removed.
Reyes-Balaguer
J
J
Allergy Department. Hospital Universitario La Fe. Valencia, Spain. galima@ono.com
Hernández de Rojas
D
D
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000276:immunology; D001249:Asthma / Q000188:drug therapy*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; C062735:zafirlukast