title: Association between response to decongestion testing and sensitizations and allergic inflammation.
abstract: BACKGROUND
  Rhinomanometry is used to measure nasal airflow, which is frequently impaired in allergic rhinitis (AR). Decongestion testing consists of spraying an intranasal vasoconstrictor drug to evaluate recovery of nasal airflow.
  
  
  OBJECTIVE
  To evaluate the relationships among type and number of sensitizations, nasal airflow recovery after topical vasoconstrictor drug use, and allergic inflammation.
  
  
  METHODS
  A total of 123 patients (112 men and 11 women; mean +/- SD age, 22.9 +/- 5.7 years) were studied: 40 with perennial AR (PAR), 43 with mixed AR (MAR), and 40 with seasonal AR (SAR). Patients with anatomic nasal defects were excluded. Total symptom scores (including nasal itching, sneezing, rhinorrhea, and nasal obstruction), sensitizations, nasal eosinophils, and cytokines (including interleukin 4 [IL-4], IL-5, and interferon-gamma) were evaluated. Electronic rhinomanometry and decongestion testing were performed in all the patients.
  
  
  RESULTS
  After administration of a topical nasal vasoconstrictor agent, mean nasal airflow significantly increased from 471 to 580 mL/s (P < .001). In 12 patients (3 with PAR, 3 with MAR, and 6 with SAR), no increase was shown. Changes from baseline were different in the PAR, MAR, and SAR populations (PAR vs MAR, P < .001; PAR vs SAR, P < .001; and MAR vs SAR, P = .25). Type of sensitization (MAR, PAR, or SAR), concentration of eosinophils, and levels of IL-4, IL-5, and interferon-gamma were associated with nasal airflow recovery of at least 120 mL/s.
  
  
  CONCLUSIONS
  This study provides the first evidence of a different response to decongestion testing taking into consideration the type of AR.
authors.affiliation: Dipartimento Patologie Testa-Collo, Padiglione Specialità (piano terzo), Azienda Ospedale-Università San Martino, Genoa, Italy. gio.cip@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Ignazio
authors.initials: I
authors.lastname: Cirillo
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Andrea
authors.initials: A
authors.lastname: Vizzaccaro
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Tosca
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000328:Adult; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D009278:Naphazoline / Q000008:administration & dosage; D014663:Nasal Decongestants / Q000008:administration & dosage; D015508:Nasal Obstruction / Q000175:diagnosis* / Q000276:immunology; D012123:Pulmonary Ventilation / Q000187:drug effects; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000276:immunology; D025363:Rhinomanometry; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000316:Adrenergic alpha-Agonists; D014663:Nasal Decongestants; D009278:Naphazoline