Role of selenium supplementation and heat stress on trehalose and glutathione content in Saccharomyces cerevisiae.
The role of selenium (Se) supplementation on glutathione, a potent intracellular redox buffer, and trehalose, a well-known stress protectant molecule, was studied. The amount of glutathione decreased significantly while that of trehalose showed a minor decrease in the cells grown in Se-supplemented medium. After heat shock, glutathione content diminished further, whereas that of trehalose increased significantly in control and Se-supplemented cells. These findings suggest the importance of trehalose as an antioxidant molecule.
Sharma
Sukesh Chander
SC
Department of Biochemistry, Panjab University, Chandigarh-160014, India. sukeshcs@hotmail.com
Anand
Maninder Singh
MS
D005978:Glutathione / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D014199:Trehalose / Q000378:metabolism*
D014199:Trehalose; D005978:Glutathione; D012643:Selenium