title: The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.
abstract: We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.
authors.affiliation: Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
authors.forename: Sabine
authors.initials: S
authors.lastname: Chlosta
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Fishman
authors.forename: Lynne
authors.initials: L
authors.lastname: Harrington
authors.forename: Erin E
authors.initials: EE
authors.lastname: Johnson
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Knutson
authors.forename: Marianne
authors.initials: M
authors.lastname: Wessling-Resnick
authors.forename: Bobby J
authors.initials: BJ
authors.lastname: Cherayil
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D027682:Cation Transport Proteins / Q000502:physiology*; D002460:Cell Line; D064451:Hepcidins; D007501:Iron / Q000378:metabolism; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D019779:Salmonella enterica / Q000254:growth & development*; D000098742:Ferroportin
chemical_list: D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C579599:Hamp protein, mouse; D064451:Hepcidins; D000098742:Ferroportin; D007501:Iron