A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate.
Autism symptoms, including impairments in language development, social interactions, and motor skills, have been difficult to model in rodents. Since children exposed in utero to sodium valproate (VPA) demonstrate behavioral and neuroanatomical abnormalities similar to those seen in autism, the neurodevelopmental effects of this antiepileptic agent were examined in mice following its pre- or postnatal administration. Exposed pups were evaluated in a battery of neurodevelopmental procedures designed to assess VPA-induced retardation (wherein a behavior fails to mature on schedule), regression (wherein a behavior does mature on time but then deteriorates), or intrusions (wherein normal behaviors are overshadowed by stereotypic or self-injurious behaviors). The resulting observations were interpreted in the context of this new strategy to model autism.
Wagner
George C
GC
Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.
Reuhl
Kenneth R
KR
Cheh
Michelle
M
McRae
Paulette
P
Halladay
Alycia K
AK
D000818:Animals; D000831:Animals, Newborn; D000927:Anticonvulsants / Q000633:toxicity*; D001288:Attention / Q000187:drug effects; D001321:Autistic Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D008607:Intellectual Disability / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012043:Regression, Psychology; D016728:Self-Injurious Behavior / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D013239:Stereotyped Behavior / Q000187:drug effects; D014635:Valproic Acid / Q000633:toxicity*
D000927:Anticonvulsants; D014635:Valproic Acid