title: Increased coronary sinus blood temperature: correlation with systemic inflammation.
abstract: BACKGROUND
  Recent studies have shown that patients with single vessel coronary artery disease (CAD) suffering from acute coronary syndromes (ACS) have increased coronary sinus (CS) blood temperature compared with the right atrium (RA). The aim of this study was to investigate whether there is a correlation between systemic inflammatory indexes and CS temperature and whether there is a difference in CS temperature between patients with single vs. multivessel disease. MATERIALS AND METHODS We included consecutive patients scheduled for coronary angiography for recent-onset chest pain evaluation. We measured C-reactive protein (CRP) levels in the study population. Coronary sinus and RA blood temperature measurements were performed by a 7F thermography catheter. DeltaTau was calculated by subtracting the RA from the CS blood temperature.
  
  
  RESULTS
  The study population comprised 53 patients with ACS, 25 patients with stable angina (SA) and 22 subjects without CAD (control group). DeltaTau was greater in patients with ACS and with SA compared with the control group (0.22 +/- 0.10 degrees C, 0.18 +/- 0.04 degrees C vs. 0.14 +/- 0.07 degrees C, P < 0.01 for both comparisons). The ACS group had greater DeltaTau compared with the SA group, although the difference did not reach statistical significance (P = 0.09). Eighteen (39.1%) out of 46 patients with multivessel disease had three-vessel disease and 28 (60.8%) had two-vessel disease. DeltaTau between patients with multivessel and single vessel disease was similar (0.22 +/- 0.01 degrees C, 0.19 +/- 0.01 degrees C, P = 0.17). The levels of CRP were well correlated with DeltaTau (R = 0.35b, P < 0.01).
  
  
  CONCLUSIONS
  Systemic inflammation is well correlated with CS temperature; thus, an inflammatory process could be the underlying mechanism for increased heat production from the myocardium.
authors.affiliation: First Department of Cardiology, Athens Medical School, Hippokration Hospital, Greece. ktoutouz@otenet.gr
authors.forename: K
authors.initials: K
authors.lastname: Toutouzas
authors.forename: M
authors.initials: M
authors.lastname: Drakopoulou
authors.forename: V
authors.initials: V
authors.lastname: Markou
authors.forename: P
authors.initials: P
authors.lastname: Stougianos
authors.forename: E
authors.initials: E
authors.lastname: Tsiamis
authors.forename: D
authors.initials: D
authors.lastname: Tousoulis
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001790:Blood Physiological Phenomena; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology; D003331:Coronary Vessels / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013696:Temperature
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein