Transmembrane domain-dependent functional oligomerization of syndecans.
Cell surface adhesion receptors of the syndecan family initiate intracellular events through clustering of receptors. This crucial clustering occurs through receptor dimerization or oligomerization, which is mediated by receptor transmembrane domains. However, the exact role of the transmembrane domain during receptor activation is not fully understood. Researchers have not yet determined whether the transmembrane domain functions solely in the physical aspects of receptor clustering, or whether the domain has additional functional roles. Here we review recent advances in understanding the functionality of transmembrane domain-dependent oligomerization of syndecan cell adhesion receptor.
Yi
Jae Youn
JY
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Korea Atomic Energy Research Institute, Seoul 139-706, Korea.
Han
Innoc
I
Oh
Eok-Soo
ES
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry* / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation; D011509:Proteoglycans / Q000737:chemistry* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000502:physiology; D053667:Syndecans
D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D011956:Receptors, Cell Surface; D053667:Syndecans