Pulmonary inflammation and bronchopulmonary dysplasia.
Various pre- and postnatal risk factors, which act additively or synergistically induce an injurious inflammatory response in the airways and the pulmonary interstitium of preterm infants with bronchopulmonary dysplasia. This inflammatory response is characterized by an accumulation of neutrophils and macrophages as well as an arsenal of proinflammatory mediators that affect the endothelium and alveolar-capillary integrity. Besides proinflammatory cytokines and toxic oxygen radicals, lipid mediators as well as potent proteases may be responsible for acute lung injury. There is increasing evidence that an imbalance between pro- and anti-inflammatory factors, which should protect the alveoli and lung tissue, are key features in the pathogenesis of bronchopulmonary dysplasia. In addition, a subnormal generation of growth factors may affect alveolarization and vascular development in preterm infants with bronchopulmonary dysplasia. In this condensed review article, the current concepts on the possible role of inflammation in the evolution of bronchopulmonary dysplasia will be summarized.
Speer
C P
CP
Department of Pediatrics, University Children's Hospital, Würzburg, Germany. speer_c@klinik.uni-wuerzburg.de
D015824:Blood-Air Barrier / Q000503:physiopathology; D001997:Bronchopulmonary Dysplasia / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D002633:Chemotaxis; D002821:Chorioamnionitis / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000150:complications / Q000209:etiology / Q000378:metabolism; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis; D008264:Macrophages; D009504:Neutrophils; D010100:Oxygen / Q000009:adverse effects; D010447:Peptide Hydrolases / Q000378:metabolism; D011014:Pneumonia / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D011650:Pulmonary Alveoli / Q000503:physiopathology; D012121:Respiration, Artificial / Q000009:adverse effects; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016207:Cytokines; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D010447:Peptide Hydrolases; D010100:Oxygen