title: [Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance].
abstract: OBJECTIVE
  To evaluate expressions of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in primary prostate cancer and its clinical significance.
  
  
  METHODS
  Expressions of COX-2 and VEGF were detected by immunohistochemical assay in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples.
  
  
  RESULTS
  COX-2 and VEGF levels in prostate cancer were much higher than those in BPH. The degrees of cancer malignancy and invasion positively correlated with the expressions of COX-2 and VEGF. COX-2 level positively correlated with VEGF level.
  
  
  CONCLUSIONS
  The abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which are hopeful to be used for the assistant diagnosis and the prediction of prognosis of prostate cancer.
authors.affiliation: Department of Urology, the Affiliated Hospital to Medical College, Yanbian University, Yanji, Jilin, China. jintiexiong@yeah.net
authors.forename: Tie-xiong
authors.initials: TX
authors.lastname: Jin
authors.forename: Xiao-gang
authors.initials: XG
authors.lastname: Li
authors.forename: Wen-yuan
authors.initials: WY
authors.lastname: Wu
authors.forename: Dong-ming
authors.initials: DM
authors.lastname: Piao
authors.forename: Jing-yan
authors.initials: JY
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Sang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human