title: Development of the 1,2-oxaza-Cope rearrangement.
abstract: A method for a concise assembly of oxazine rings based on a Lewis acid-promoted hetero-Cope rearrangement is described. The hetero-Cope rearrangement features the first examples of the [3,3]-sigmatropic transpositions involving the nitroso group. A variety of functionalized substrates have been subjected to the reaction. The described method has a strong potential for the synthesis of marine natural products containing oxazine rings.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA. zakarian@chem.fsu.edu
authors.forename: Armen
authors.initials: A
authors.lastname: Zakarian
authors.forename: Chong-Dao
authors.initials: CD
authors.lastname: Lu
mesh_terms: D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry*
chemical_list: D010078:Oxazines