Radical-mediated opening of 2,3-epoxy alcohols using Cp2TiCl: stereoselective construction of quaternary chiral centers.
Radical-mediated opening of chiral 2,3-epoxy alcohols regioselectively at the 2-position using Cp2TiCl and trapping the intermediate radical with methyl acrylate and acrylonitrile led to the stereoselective formation of tetrasubstituted chiral centers.
Chakraborty
Tushar Kanti
TK
Indian Institute of Chemical Technology, Hyderabad 500 007, India. chakraborty@iict.res.in
Samanta
Rajarshi
R
Das
Sanjib
S
D000438:Alcohols / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000438:Alcohols; D005609:Free Radicals; D014025:Titanium