title: Impact of pulmonary rehabilitation on psychosocial morbidity in patients with severe COPD.
abstract: OBJECTIVE
  To assess the effect of pulmonary rehabilitation (PR) on psychosocial morbidity, functional exercise capacity, and health-related quality of life (HRQL) in patients with severe COPD.
  
  
  METHODS
  A prospective, randomized, controlled trial with blinding of outcome assessment and data analysis.
  
  
  METHODS
  A tertiary-care respiratory service.
  
  
  METHODS
  Forty patients (mean age, 65 +/- 8 years [+/- SD]) with severe chronic flow limitation (FEV(1), 35 +/- 13%) without respiratory failure (Pao(2), 72 +/- 9 mm Hg; Paco(2), 42 +/- 5 mm Hg) were randomized either to a control group or to a PR group (PRG).
  
  
  METHODS
  Sixteen weeks of PR that included breathing retraining and exercise.
  
  
  METHODS
  At baseline and 16 weeks, we evaluated psychosocial morbidity using two questionnaires (the Millon Behavior Health Inventory [MBHI] and the Revised Symptom Checklist [SCL-90-R]) and measured 6-min walk distance (6WMD) and HRQL using the Chronic Respiratory Questionnaire (CRQ).
  
  
  RESULTS
  We found differences in favor of the PRG in the following MBHI domains: introversive, forceful, and sensitive personality styles (all p </= 0.05) and chronic tension (p </= 0.01). Results of the depression, hostility, global severity, positive symptom distress index (all p </= 0.01), somatization, anxiety, psychoticism, and positive symptom (all p </= 0.05) domains of the SCL-90-R favored the PRG. We also found statistically and clinically significant differences between groups in 6MWD (85 m; p < 0.01) and in two domains of the CRQ: dyspnea (1.0; p < 0.01) and mastery (0.6; p < 0.05). The other two domains of CRQ showed strong trends in favor of PRG: 0.7 for both fatigue and emotional function (minimal important difference, 0.5).
  
  
  CONCLUSIONS
  PR may decrease psychosocial morbidity in COPD patients even when no specific psychological intervention is performed. Findings from this study also confirm the positive impact of PR on functional exercise capacity and HRQL.
authors.affiliation: Departament de Pneumologia, Hospital de la Santa Creu i de Sant Pau, Universitat Autonoma de Barcelona [corrected] Barcelona, Spain. mguellr@santpau.es
authors.forename: Rosa
authors.initials: R
authors.lastname: Güell
authors.forename: Vanesa
authors.initials: V
authors.lastname: Resqueti
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sangenis
authors.forename: Fatima
authors.initials: F
authors.lastname: Morante
authors.forename: Bernardi
authors.initials: B
authors.lastname: Martorell
authors.forename: Pere
authors.initials: P
authors.lastname: Casan
authors.forename: Gordon H
authors.initials: GH
authors.lastname: Guyatt
mesh_terms: D000368:Aged; D001945:Breathing Exercises; D015444:Exercise; D017079:Exercise Tolerance; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011581:Psychological Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000523:psychology* / Q000534:rehabilitation*; D011788:Quality of Life; D012720:Severity of Illness Index