title: Changes of interleukin-6 and related factors as well as gastric intramucosal pH during colorectal and orthopaedic surgical procedures.
abstract: OBJECTIVE
  To investigate the changes of perioperative serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures.
  
  
  METHODS
  Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation. Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol. pHi and plasma lactate were also measured at the same time points.
  
  
  RESULTS
  Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation. CRP was not detectable until the first day after operation. Peak concentration of IL-6 had positive relationship with CRP. These variables changed more significantly in colorectal group than that in orthopaedic group (P < 0.05). pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P < 0.05).
  
  
  CONCLUSIONS
  IL-6 may reflect tissue damage more sensitively than CRP. Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.
authors.affiliation: Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730. hongxihxcn@yahoo.com
authors.forename: Xi
authors.initials: X
authors.lastname: Hong
authors.forename: Tie-hu
authors.initials: TH
authors.lastname: Ye
authors.forename: Xiu-hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Ren
authors.forename: Yu-guang
authors.initials: YG
authors.lastname: Huang
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Bu
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006863:Hydrogen-Ion Concentration; D015850:Interleukin-6 / Q000097:blood*; D007405:Intervertebral Disc Displacement / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D013130:Spinal Stenosis / Q000097:blood* / Q000503:physiopathology / Q000601:surgery
chemical_list: D015850:Interleukin-6; D019344:Lactic Acid; D002097:C-Reactive Protein; D006854:Hydrocortisone