title: Use of [18F]fluorodeoxyglucose positron emission tomography in evaluating locally recurrent and metastatic adrenocortical carcinoma.
abstract: BACKGROUND
  Adrenocortical carcinomas are uncommon, and their evaluation by [(18)F]fluorodeoxyglucose positron emission tomography (FDG PET) has not been well evaluated.
  
  
  OBJECTIVE
  The purpose of this study was to examine the potential utility of FDG PET in the detection of recurrent or metastatic adrenocortical carcinoma.
  
  
  METHODS
  In patients with known adrenocortical carcinoma who underwent FDG-PET imaging for suspected recurrence or metastasis, FDG activity was compared with other imaging findings, clinical features, and the presence or absence of disease as confirmed by resection, biopsy, or clinical follow-up.
  
  
  METHODS
  The study took place at four tertiary referral centers.
  
  
  METHODS
  Twelve patients (10 females and two males, 5-71 yr of age) were evaluated.
  
  
  METHODS
  The main outcome measures were FDG activity, other imaging findings, and clinical features.
  
  
  RESULTS
  Abnormal FDG uptake correctly indicated tumor recurrence in 10 patients. One patient with no abnormal FDG activity had a morphological abnormality subsequently proven to be a postoperative scar. Two patients, one with very small pulmonary lesions and one with a hepatic metastasis, had false-negative findings.
  
  
  CONCLUSIONS
  Most adrenocortical carcinomas accumulate and retain FDG and thus can be visualized by PET. However, false-negative findings are possible, especially with very small lesions.
authors.affiliation: Department of Radiological Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Mail Stop 752, Memphis, Tennessee 38105-2794, USA.
authors.forename: Gavin C
authors.initials: GC
authors.lastname: Mackie
authors.forename: Barry L
authors.initials: BL
authors.lastname: Shulkin
authors.forename: Raul C
authors.initials: RC
authors.lastname: Ribeiro
authors.forename: Francis P
authors.initials: FP
authors.lastname: Worden
authors.forename: Paul G
authors.initials: PG
authors.lastname: Gauger
authors.forename: Rajen J
authors.initials: RJ
authors.lastname: Mody
authors.forename: Len P
authors.initials: LP
authors.lastname: Connolly
authors.forename: Ghada
authors.initials: G
authors.lastname: Kunter
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Jerold W
authors.initials: JW
authors.lastname: Wallis
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hurwitz
authors.forename: David E
authors.initials: DE
authors.lastname: Schteingart
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005188:False Negative Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18