Mining the oocyte transcriptome.
Mammalian folliculogenesis and oocyte physiology are complex and not fully understood. However, major advances over the past 15 years in our ability to create and study in vivo models have improved our understanding of these essential physiological processes. More recently, the availability of vast arrays of DNA sequence information in the forms of "complete" genomes, expressed sequence tag libraries and microarray data from reproductive tissues have stimulated the discovery of new information through genome scanning, prediction programs and in silico screening techniques. These technological improvements will help to expand our understanding of folliculogenesis and oocyte physiology and improve human reproductive health.
Andreu-Vieyra
Claudia
C
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Lin
Yi-Nan
YN
Matzuk
Martin M
MM
D055430:Bone Morphogenetic Protein 15; D002450:Cell Communication; D017630:Connexins / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D006107:Granulosa Cells / Q000166:cytology; D055429:Growth Differentiation Factor 9; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008540:Meiosis; D020411:Oligonucleotide Array Sequence Analysis; D009865:Oocytes / Q000737:chemistry* / Q000166:cytology / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology; D034622:RNA Interference; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
C525901:BMP15 protein, human; D055430:Bone Morphogenetic Protein 15; D017630:Connexins; C525897:GDF9 protein, human; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger