Study on metabolites of 2,5-dimethoxy-4-bromamphetamine (DOB) in human urine using gas chromatography-mass spectrometry.
The study of the biotransformation of a new synthetic drug 2,5-dimethoxy-4-bromamphetamine (DOB) and identification of its metabolites in urine of a poisoned person is described using gas chromatography mass spectrometry (GC-MS) with various ways of derivatization. It has been confirmed that one of its metabolic pathways leads to the corresponding 2-O-desmethyl and 5-O-desmethyl metabolites when the latter is prevailing. It is important to know the metabolism of this neurotoxic and hallucinogenic substance as it is a prerequisite for developing reliable toxicological diagnostic procedures and for assessment of toxicological risks.
Beránková
Katerina
K
Institute of Forensic Medicine and Toxicology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Balíková
Marie
M
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000031:analogs & derivatives* / Q000506:poisoning / Q000652:urine; D062787:Drug Overdose; D008401:Gas Chromatography-Mass Spectrometry; D006213:Hallucinogens / Q000506:poisoning / Q000652:urine*; D006801:Humans; D015813:Substance Abuse Detection
D006213:Hallucinogens; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; C003943:2,5-dimethoxy-4-bromoamphetamine