Focusing on genomic and phenomic correlations in respiration of non-melanotic skin cancers.
In recent years, with the development of techniques in modem molecular biology, it has become possible to study the genetic basis of carcinogenesis down to the level of DNA sequence. Major advances have been made in our understanding of the genes involved in cell cycle control and descriptions of mutations in those genes. These developments have led to the definition of the role of specific oncogenes and tumour suppressor genes in several cancers, including, for example, colon cancers and some forms of breast cancer. Work reported from our laboratory has led to the identification of a number of candidate genes involved in the development of non-melanotic skin cancers. In this chapter, we attempt to further explain the observed (phenomic) alterations in metabolic pathways associated with oxygen consumption with the changes at the genetic level.
Maguire
David J
DJ
Lintell
Nicholas A
NA
McCabe
Michael
M
Griffiths
L
L
D001483:Base Sequence; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000235:genetics; D042967:Electron Transport Complex I / Q000235:genetics; D006801:Humans; D024101:Mitochondrial Proteins / Q000235:genetics; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D009245:NADH Dehydrogenase; D009857:Oncogenes; D010101:Oxygen Consumption; D000072079:Patched Receptors; D016133:Polymerase Chain Reaction; D011956:Receptors, Cell Surface / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism*
D004273:DNA, Neoplasm; D024101:Mitochondrial Proteins; C508060:NDUFA5 protein, human; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D016660:NAD(P)H Dehydrogenase (Quinone); D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I; C116384:NDUFA8 protein, human