title: Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species.
abstract: The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray-dried powders obtained from P. alata and P. edulis, known in Brazil as 'maracujá'. Male adult Swiss rats were treated with 200, 400 and 800 mg/kg of spray-dried powders p.o. and anxiolytic activity was evaluated using the elevated plus-maze test. The spray-dried powders showed anxiolytic activity in doses of 400 and 800 mg/kg. Our results support the potential anxiolytic effect of Passiflora spray-dried powders (P. alata and P. edulis).
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. flavio@saude.upf.br
authors.forename: Flávio H
authors.initials: FH
authors.lastname: Reginatto
authors.forename: Fernanda
authors.initials: F
authors.lastname: De-Paris
authors.forename: Raquel D
authors.initials: RD
authors.lastname: Petry
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: George González
authors.initials: GG
authors.lastname: Ortega
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
authors.forename: Eloir P
authors.initials: EP
authors.lastname: Schenkel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D001938:Brazil; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008519:Medicine, Traditional; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts