title: Effects of sugar cane extract on pseudorabies virus challenge of pigs.
abstract: This experiment aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection. Twelve-week-old experimental pigs were fed with SCE (500 mg/kg of body weight per day) for 3 days and challenged with PrV (2 x 10(5) TCID(50)) on the second day. Pigs that were only challenged with PrV and without SCE-treatment served as controls. The leukocyte functional assays were performed on the 7th and 14th day post-PrV challenge. Our results showed a significant enhancement (P<0.05) of natural killer cytotoxicity, lymphocyte proliferation, phagocytic function of monocytes, and interferon-gamma (IFN-gamma) production of CD4(+) and gammadelta T cells in the SCE-treated pigs compared with the controls. In addition, SCE administration reduced the severity of clinical signs and brain lesion in the course of disease in PrV-challenged pigs. SCE-treated pigs showed a 12% growth enhancement compared with untreated controls. SCE administration had an immunostimulating effect on porcine immunity that may subsequently enhance protective activities against PrV infection which may be extensively applied in field for the prevention of infections.
authors.affiliation: Graduate Institute of Veterinary Pathology, National Chung Hsing University, 402 Taichung, Japan.
authors.forename: Dan-Yuan
authors.initials: DY
authors.lastname: Lo
authors.forename: Maw-Sheng
authors.initials: MS
authors.lastname: Chien
authors.forename: Kuang-Sheng
authors.initials: KS
authors.lastname: Yeh
authors.forename: Kenji
authors.initials: K
authors.lastname: Koge
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Lin
authors.forename: Shih-Ling
authors.initials: SL
authors.lastname: Hsuan
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Lee
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D004435:Eating / Q000187:drug effects; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D006651:Histocytochemistry / Q000662:veterinary; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count / Q000662:veterinary; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology*; D011557:Pseudorabies / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control / Q000821:virology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D031786:Saccharum; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000821:virology*
chemical_list: D010936:Plant Extracts; D016692:Receptors, Antigen, T-Cell, gamma-delta