Role of the histone-like nucleoid structuring protein in colonization, motility, and bile-dependent repression of virulence gene expression in Vibrio cholerae.
Bile-mediated repression of virulence gene expression is relieved in a Vibrio cholerae hns mutant. The mutant also exhibited reduced motility due to lower flrA expression, higher in vivo production of the virulence factors, and lower colonization efficiency. The colonization defect of the mutant was due to low FlrA production.
Ghosh
Amalendu
A
Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta 700 032, India.
Paul
Kalidas
K
Chowdhury
Rukhsana
R
D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D001646:Bile / Q000502:physiology*; D002772:Cholera Toxin / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000502:physiology*; D036781:Fimbriae Proteins / Q000096:biosynthesis; D007422:Intestines / Q000382:microbiology; D051379:Mice; D009068:Movement; D012097:Repressor Proteins / Q000502:physiology*; D014734:Vibrio cholerae / Q000472:pathogenicity*; D037521:Virulence Factors / Q000235:genetics*
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria; D012097:Repressor Proteins; C085807:TcpA protein, Vibrio cholerae; D037521:Virulence Factors; D036781:Fimbriae Proteins; D002772:Cholera Toxin