[Antagonism of vitamin E on lipid peroxidation in testis of male rats with carbon disulfide].
OBJECTIVE
To study the antagonistic joint action of vitamin E (VE) lipid peroxidation of testis in the male rats with carbon disulfide (CS2).


METHODS
36 wistar male rats were randomly dicided into six groups. It took 10-week for the rats to breath CS2 in different concentrations (0, 50, 250 and 1250 mg/m3), respectively, CS2 (1250 mg/m3) with VE (250 mg/kg diet) and VE (250 mg/kg diet) group. After 10-week treatment, rats were killed and the following parameters of lipid peroxidation in testis were determined:SOD, MDA, GST, GSH, GSH-px, NO, NOS and iNOS.


RESULTS
Compare with the control group, SOD, GST, GSH-px, NOS and iNOS activity were decreased (P < 0.05 or P < 0.01), GSH, NO content decreased also, MDA content was increased (P < 0.01). After the antioxidant VE treatmented, the parameters were significantly increased (the amount of MDA was decreased).


CONCLUSIONS
The antioxidant VE significantly protects against on lipid peroxidation in testes of male rats with CS2.
Chen
Guo-Yuan
GY
Department of Environmental and Occupational Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Deng
Jing
J
Tan
Hao
H
Hu
Feng-Xian
FX
Chai
Lianhua
L
Liu
Weidong
W
Liu
Sihai
S
Yi
Yuanchuan
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002246:Carbon Disulfide / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E; D009569:Nitric Oxide; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002246:Carbon Disulfide