title: Free-radical version of the strecker synthesis of alpha-aminoamides promoted by aqueous H2O2/TiCl3/HCONH2 system.
abstract: A new reaction of general synthetic interest representing the free-radical version of the Strecker synthesis to alpha-aminoamides is reported. A hydroxy radical, generated by Ti(III) one-electron reduction of H2O2, abstracts a H atom from the C-H bond of formamide, and the resulting carbamoyl radical adds to the C atom of aldimines formed in situ, leading to a one-pot synthesis of alpha-aminoamides. Several types of aldehydes can participate in this process.
authors.affiliation: Dipartimento di Chimica, Materiali e Ingegneria Chimica G. Natta, Politecnico di Milano, Sezione Chimica, Italy.
authors.forename: Rosalba
authors.initials: R
authors.lastname: Cannella
authors.forename: Angelo
authors.initials: A
authors.lastname: Clerici
authors.forename: Walter
authors.initials: W
authors.lastname: Panzeri
authors.forename: Nadia
authors.initials: N
authors.lastname: Pastori
authors.forename: Carlo
authors.initials: C
authors.lastname: Punta
authors.forename: Ombretta
authors.initials: O
authors.lastname: Porta