Regulation of NF-kappaB transcriptional activity.
Nuclear factor kappaB (NF-kappaB) is regarded as a key regulator of inflammation; hence, several inflammatory diseases result from deregulation of NF-kappaB signaling. There is, however, also increasing evidence for a preponderant role of NF-kappaB in tumor development and progression. Constitutive activation of NF-kappaB activity by signaling defects, mutations or chromosomal rearrangements can be found in a wide variety of cancers. Additionally, a causal link between inflammation and cancer has been noted, which makes NF-kappaB an interesting target for development of both anti-inflammatory and anti-cancer therapeutics. Here, we review current knowledge of NF-kappaB signal transduction, focusing on the regulation of its transcriptional activity by post-translational modification of the NF-kappaB subunits.
Vermeulen
Linda
L
Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Molecular Biology, Ghent University, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
Vanden Berghe
Wim
W
Haegeman
Guy
G
D006801:Humans; D007249:Inflammation; D016328:NF-kappa B / Q000096:biosynthesis* / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D014158:Transcription, Genetic
D016328:NF-kappa B