Desymmetrization of cyclic anhydrides using dihydroxy compounds: selective synthesis of macrocyclic tetralactones.
[reaction: see text] The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20-34) having a wide variety of spacers is described. The structure is confirmed by the representative single-crystal X-ray analysis. The multiple reduction of unsaturated macrocyclic tetralactones is also illustrated. This method is mild, selective, and efficient and achieves high yield.
Muthusamy
Sengodagounder
S
Central Salt & Marine Chemicals Research Institute (CSIR), Bhavnagar, Gujarat 364 002, India. muthu@csmcri.org
Gnanaprakasam
Boopathy
B
Suresh
Eringathodi
E