Effect of intravenous infusion of glyceryl trinitrate on gastric and small intestinal motor function in healthy humans.
BACKGROUND
Glyceryl trinitrate is a donor of nitric oxide that relaxes smooth muscle cells of the gastrointestinal tract. Little is known about the effect of glyceryl trinitrate on gastric emptying and no data exist on the possible effect of glyceryl trinitrate on small intestinal transit.


OBJECTIVE
To examine the effect of intravenous infusion of glyceryl trinitrate on gastric and small intestinal motor function after a meal in healthy humans.


METHODS
Nine healthy volunteers participated in a placebo-controlled, double-blind, crossover study. Each volunteer was examined during intravenous infusion of glyceryl trinitrate 1 microg/kg x min or saline. A gamma camera technique was used to measure gastric emptying and small intestinal transit after a 1600-kJ mixed liquid and solid meal. Furthermore, duodenal motility was assessed by manometry.


RESULTS
Glyceryl trinitrate did not change gastric mean emptying time, gastric half emptying time, gastric retention at 15 min or small intestinal mean transit time. Glyceryl trinitrate did not influence the frequency of duodenal contractions, the amplitude of duodenal contractions or the duodenal motility index.


CONCLUSIONS
Intravenous infusion of glyceryl trinitrate 1 microg/kg x min does not induce major changes in gastric or small intestinal motor function after a 1600-kJ meal in healthy volunteers.
Madsen
J L
JL
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Copenhagen, Denmark. jan.lysgaard.madsen@hh.hosp.dk
Fuglsang
S
S
Graff
J
J
D018592:Cross-Over Studies; D004311:Double-Blind Method; D015902:Gamma Cameras; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D008365:Manometry; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology*; D019518:Postprandial Period; D011877:Radionuclide Imaging; D017211:Treatment Failure; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D005996:Nitroglycerin