A common genetic variant is associated with adult and childhood obesity.
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
Herbert
Alan
A
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA. aherbert@bu.edu
Gerry
Norman P
NP
McQueen
Matthew B
MB
Heid
Iris M
IM
Pfeufer
Arne
A
Illig
Thomas
T
Wichmann
H-Erich
HE
Meitinger
Thomas
T
Hunter
David
D
Hu
Frank B
FB
Colditz
Graham
G
Hinney
Anke
A
Hebebrand
Johannes
J
Koberwitz
Kerstin
K
Zhu
Xiaofeng
X
Cooper
Richard
R
Ardlie
Kristin
K
Lyon
Helen
H
Hirschhorn
Joel N
JN
Laird
Nan M
NM
Lenburg
Marc E
ME
Lange
Christoph
C
Christman
Michael F
MF
D000328:Adult; D001741:Black or African American; D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D005060:Europe; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D044465:White People
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins