title: A simple linear regression method for quantitative trait loci linkage analysis with censored observations.
abstract: Standard quantitative trait loci (QTL) mapping techniques commonly assume that the trait is both fully observed and normally distributed. When considering survival or age-at-onset traits these assumptions are often incorrect. Methods have been developed to map QTL for survival traits; however, they are both computationally intensive and not available in standard genome analysis software packages. We propose a grouped linear regression method for the analysis of continuous survival data. Using simulation we compare this method to both the Cox and Weibull proportional hazards models and a standard linear regression method that ignores censoring. The grouped linear regression method is of equivalent power to both the Cox and Weibull proportional hazards methods and is significantly better than the standard linear regression method when censored observations are present. The method is also robust to the proportion of censored individuals and the underlying distribution of the trait. On the basis of linear regression methodology, the grouped linear regression model is computationally simple and fast and can be implemented readily in freely available statistical software.
authors.affiliation: Institute of Evolutionary Biology, University of Edinburgh, Scotland. carl.anderson@qimr.edu.au
authors.forename: Carl A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Allan F
authors.initials: AF
authors.lastname: McRae
authors.forename: Peter M
authors.initials: PM
authors.lastname: Visscher
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D016013:Likelihood Functions; D016014:Linear Models; D008957:Models, Genetic; D040641:Quantitative Trait Loci; D012984:Software