title: Effect of explosive noise on gastrointestinal transit and plasma levels of polypeptide hormones.
abstract: OBJECTIVE
  To investigate the effect of firing noise on gastrointestinal transit and probe its mechanism by measuring the levels of plasma polypeptide hormones.
  
  
  METHODS
  A total of 64 SD rats were randomly divided into a control group and three stimulating groups. Firing noise of different intensity by sub-machine guns was used as inflicting factor. The effect of firing noise on liquid substance gastrointestinal transit and solid substance gastrointestinal transit was observed by measuring the ratio of carbon powder suspension transmitting and barium sticks transmitting respectively. Plasma levels of polypeptide hormones were measured by radio-immunoassay.
  
  
  RESULTS
  The noise accelerated gastrointestinal transit of solid food by more than 80 db;and accelerated gastrointestinal transit of liquid food significantly by more than 120 db. Meantime, plasma levels of plasma motilin (MTL)(157.47+/-16.08; 151.90+/-17.08), somatostatin (SS)(513.97+/-88.77; 458.25+/-104.30), substance P (SP)(115.52+/-20.70; 110.28+/-19.96) and vasoactive intestinal peptide (VIP) (214.21+/-63.17; 251.76+/-97.24) remarkably changed also.
  
  
  CONCLUSIONS
  Within a certain intensity range, the firing noise changes the levels of rat plasma gastrointestinal hormones, but the gastrointestinal transit is still normal. Beyond the range, the noise induces plasma hormone levels disturbance and gastrointestinal transit disorder.
authors.affiliation: Department of Gastroenterology, Tang Du Hospital of the Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China. mzb-999@163.com
authors.forename: Zhen-Bin
authors.initials: ZB
authors.lastname: Mu
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Huang
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Zhao
authors.forename: Zhen-Xiong
authors.initials: ZX
authors.lastname: Liu
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Zhang
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Wang
mesh_terms: D000818:Animals; D005107:Explosions; D005768:Gastrointestinal Hormones / Q000097:blood*; D005772:Gastrointestinal Transit; D009622:Noise; D036361:Peptide Hormones / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005768:Gastrointestinal Hormones; D036361:Peptide Hormones