title: Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.
abstract: Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.
authors.affiliation: Department of Microbiology and Molecular Genetics, ICPH Building, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103-2714, USA. Parveeni@umdnj.edu
authors.forename: Nikhat
authors.initials: N
authors.lastname: Parveen
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Cornell
authors.forename: James L
authors.initials: JL
authors.lastname: Bono
authors.forename: Christen
authors.initials: C
authors.lastname: Chamberland
authors.forename: Patricia
authors.initials: P
authors.lastname: Rosa
authors.forename: John M
authors.initials: JM
authors.lastname: Leong
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D025065:Borrelia burgdorferi / Q000235:genetics; D002352:Carrier Proteins / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D008193:Lyme Disease / Q000209:etiology*; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID; D009699:N-Glycosyl Hydrolases / Q000502:physiology*; D010957:Plasmids
chemical_list: D001426:Bacterial Proteins; C474476:Bgp protein, Borrelia burgdorferi; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009699:N-Glycosyl Hydrolases