Protein splicing of SufB is crucial for the functionality of the Mycobacterium tuberculosis SUF machinery.
The SufBCD complex is an essential component of the SUF machinery of [Fe-S] cluster biogenesis in many organisms. We show here that in Mycobacterium tuberculosis the formation of this complex is dependent on the protein splicing of SufB, suggesting that this process is a potential new target for antituberculous drugs.
Huet
Gaëlle
G
Department of Molecular Mechanisms of Mycobacterial Infections, Institut de Pharmacologie et Biologie Structurale (UMR5089), CNRS/Université Paul Sabatier Toulouse III, 205 Route de Narbonne, F-31077 Toulouse Cedex, France.
Castaing
Jean-Philippe
JP
Fournier
Didier
D
Daffé
Mamadou
M
Saves
Isabelle
I
D000995:Antitubercular Agents / Q000494:pharmacology; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D019154:Protein Splicing / Q000187:drug effects / Q000502:physiology*
D000995:Antitubercular Agents; D007506:Iron-Sulfur Proteins