title: Desymmetrization of cyclic anhydrides using dihydroxy compounds: selective synthesis of macrocyclic tetralactones.
abstract: [reaction: see text] The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20-34) having a wide variety of spacers is described. The structure is confirmed by the representative single-crystal X-ray analysis. The multiple reduction of unsaturated macrocyclic tetralactones is also illustrated. This method is mild, selective, and efficient and achieves high yield.
authors.affiliation: Central Salt & Marine Chemicals Research Institute (CSIR), Bhavnagar, Gujarat 364 002, India. muthu@csmcri.org
authors.forename: Sengodagounder
authors.initials: S
authors.lastname: Muthusamy
authors.forename: Boopathy
authors.initials: B
authors.lastname: Gnanaprakasam
authors.forename: Eringathodi
authors.initials: E
authors.lastname: Suresh