[Serum IL-1 receptor antagonist and IL-1beta in patients with Graves' opthalmopathy].
OBJECTIVE
To investigate the mechanism of Graves' ophthalmopathy (GO) and the relationship between serum IL-1 ra and IL-1beta and the effectiveness of glucocoids in treating GO.


METHODS
Serum IL-1ra and IL-1beta were measured by Enzyme linked immunosorbent assay (ELISA) and Radioimmunoassay (RIA) in three groups of people, which included 20 patients with severe GO (NOSPACES> or = IV), 20 patients with Graves' disease (GD) without ophthalmopathy, and 20 healthy volunteers. Repeated measurements were undertaken in GO patients before and after glucocoids treatment to analyze the relationship between serum IL-1ra, and IL-1beta and the effectiveness of glucocoids therapy.


RESULTS
Before glucocoids therapy,GO patients had higher serum IL-1beta and lower IL-1ra/IL-1beta ratio. Glucocoids therapy increased serum IL-1ra and decreased IL-1beta, and thus increased the IL-1ra/IL-1beta ratio.


CONCLUSIONS
Patients with GO have deficiency in IL-1ra synthesis. Glucocoids therapy can stimulate IL-1ra synthesis and inhibit IL-1beta synthesis.
Xie
Qin
Q
Gold card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Shuang-Qing
SQ
Aa
Zhen-Mei
ZM
Wei
Song-Quan
SQ
Zhao
Hong-Li
HL
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D049970:Graves Ophthalmopathy / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000097:blood
D005938:Glucocorticoids; D053583:Interleukin-1beta; D017472:Receptors, Interleukin-1; D008775:Methylprednisolone