title: Overexpression of pituitary tumor-transforming gene-1 in hepatocellular carcinoma.
abstract: OBJECTIVE
  Pituitary tumor-transforming gene-1, a recently identified proto-oncogene, was reported to be highly expressed in various tumors, such as tumors of the pituitary gland, adrenal gland, colon, ovary, endometrium, uterus, and kidney. The purpose of this study was to investigate the clinicopathologic significance of PTTG1 expression in hepatocellular carcinoma.
  
  
  METHODS
  Expression of PTTG1 mRNA was evaluated by RT-PCR in 147 HCCs and 103 paired nontumorous liver tissues.
  
  
  RESULTS
  PTTG1 was found overexpressed in 80 of 147 (61%) HCCs. Overexpression of PTTG1 correlated with alpha-fetoprotein elevation (p<0.022) and higher tumor stage (stage IIIB-IV) tumors (p<0.009), but not with tumor grade, size, and survival.
  
  
  CONCLUSIONS
  The results show that PTTG1 is overexpressed frequently in HCC, and correlated high stage tumors, indicating that overexpression of PTTG1 plays a role in the development and progression of HCC.
authors.affiliation: Department of Pathology, Min-Sheng General Hospital, Taoyuan City, Taiwan, ROC.
authors.forename: Min-Cheng
authors.initials: MC
authors.lastname: Su
authors.forename: Hey-Chi
authors.initials: HC
authors.lastname: Hsu
authors.forename: Yu-Jung
authors.initials: YJ
authors.lastname: Liu
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Jeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009367:Neoplasm Staging; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000378:metabolism; D064249:Securin; D051176:beta Catenin / Q000235:genetics
chemical_list: C495270:CTNNB1 protein, human; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D064249:Securin; D051176:beta Catenin; C578002:pituitary tumor-transforming protein 1, human