title: Lipid rafts: membrane triage centers.
abstract: Both biochemical and live cell imaging studies suggest the existence of lipid rafts, specialized membrane microdomains that promote interaction among signaling molecules. Although their composition is still poorly understood, these highly dynamic domains are enriched in cholesterol, sphingolipids, and particular groups of proteins. The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear.
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Chicago, IL 60611, USA.
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Wang
authors.forename: Amy S
authors.initials: AS
authors.lastname: Paller
mesh_terms: D066246:ErbB Receptors / Q000378:metabolism*; D005679:G(M3) Ganglioside / Q000502:physiology; D006801:Humans; D051861:Kangai-1 Protein / Q000502:physiology; D008024:Ligands; D021962:Membrane Microdomains / Q000502:physiology*; D047392:beta-Cyclodextrins / Q000494:pharmacology
chemical_list: D005679:G(M3) Ganglioside; D051861:Kangai-1 Protein; D008024:Ligands; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D066246:ErbB Receptors