Time-course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom.
This study examined the effect of Echis pyramidum (EP) venom on time-course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h post-envenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom.
Al Asmari
Abdurrahman
A
Research Center, Armed Forces Hospital, P.O. Box 7897 (775S), Riyadh 11159, Saudi Arabia. rkh_research@yahoo.com
Al Moutaery
Khalaf
K
Manthari
Rajamohamed Abbas
RA
Khan
Haseeb Ahmad
HA
D000818:Animals; D001921:Brain / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D009928:Organ Specificity; D012910:Snake Venoms / Q000494:pharmacology*; D017819:Viperidae
D012910:Snake Venoms; D008315:Malondialdehyde