title: Disinhibition and borderline personality disorder.
abstract: We review different conceptions of inhibitory control that may be relevant to the regulatory problems featured in borderline personality disorder (BPD). These conceptions have often been framed with regard to personality traits of inhibitory control, but can also be related to cognitive measures of response suppression as well as affect regulation. Reactive behavioral inhibition is relatively unstudied in relation to BPD. A substantial amount of literature links executive function problems with BPD, but that literature has not isolated executive response inhibition nor been controlled for other personality disorder symptoms of antisociality, attention-deficit/hyperactivity disorder (ADHD), or depression, anxiety, or posttraumatic symptoms. We therefore conducted a study of this question looking at BPD symptoms in an adult sample with a small number of BPD subjects and other disorders. Results indicated that symptoms of BPD were correlated with response inhibition (measured by stop signal reaction time) even after controlling for the overlap of stop inhibition with ADHD, antisociality, and other Axis II disorder symptoms. We conclude by hypothesizing discrete developmental routes to BPD, based on different mechanism breakdowns, which would be amenable to empirical investigation at the cognitive or trait level of analysis.
authors.affiliation: Department of Psychology, Michigan State University, East Lansing, MI 48823-1116, USA. nigg@msu.edu
authors.forename: Joel T
authors.initials: JT
authors.lastname: Nigg
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Silk
authors.forename: Gillian
authors.initials: G
authors.lastname: Stavro
authors.forename: Torri
authors.initials: T
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000523:psychology; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000523:psychology*; D002648:Child; D002755:Choice Behavior; D015897:Comorbidity; D003463:Cues; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D004193:Discrimination Learning; D006801:Humans; D007266:Inhibition, Psychological; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D010552:Personality Assessment; D010554:Personality Disorders / Q000175:diagnosis / Q000523:psychology; D011597:Psychomotor Performance; D011930:Reaction Time; D013223:Statistics as Topic; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000523:psychology