title: Iso-osmolar contrast medium better preserves short- and long-term renal function after cardiovascular catheterizations in patients with severe baseline renal insufficiency.
abstract: BACKGROUND
  Iso-osmolar iodixanol was shown to least affect very-short-term renal function. However, its short- and long-term renal effects after cardiovascular catheterizations in severe renal insufficiency remain unknown.
  
  
  METHODS
  Patients undergoing elective cardiovascular catheterizations and having pre-procedural serum creatinine (Scr) > or =2.5 mg/dl were prospectively studied. The results were compared to those of historical controls who received iopromide.
  
  
  RESULTS
  The iodixanol group included 27 patients, aged 73+/-1 years, and the case-matched control group consisted of another 27 patients, aged 71+/-1 years. The baseline Scr were 3.0+/-0.3 and 3.0+/-0.2 mg/dl respectively. Although the Scr at 3 months was similar, the Scr at 6 months was lower in the iodixanol group (2.7+/-0.3 vs 4.2+/-0.5 mg/dl, p = 0.017). The absolute and percentage increments in Scr at 3 months (0.0+/-0.2 vs 0.6+/-0.2 mg/dl, p = 0.014, and 1+/-4% vs 24+/-6%, p = 0.003, respectively) and 6 months (-0.3+/-0.2 vs 1.3+/-0.4 mg/dl, p = 0.001, and -10+/-5% vs 47+/-12%, p < 0.001, respectively) were lower in the iodixanol group.
  
  
  CONCLUSIONS
  Iodixanol better preserves short- and long-term renal outcomes in patients with severe baseline renal insufficiency.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Hsieh
authors.forename: Tsun-Jui
authors.initials: TJ
authors.lastname: Liu
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Her
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Lin
authors.forename: Kuo-Yang
authors.initials: KY
authors.lastname: Wang
authors.forename: Ying-Tsung
authors.initials: YT
authors.lastname: Chen
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Ting
authors.forename: Wen-Lieng
authors.initials: WL
authors.lastname: Lee
mesh_terms: D006328:Cardiac Catheterization; D003287:Contrast Media; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009994:Osmolar Concentration; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000503:physiopathology*; D012720:Severity of Illness Index; D013997:Time Factors; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol