title: [Effect of perioperative continuous epidural morphine administration on plasma D-dimer in patients undergoing total hip replacement].
abstract: OBJECTIVE
  To evaluate the effect of perioperative continuous epidural morphine administration on plasma D-dimer level in patients undergoing total hip replacement.
  
  
  METHODS
  Forty ASA I-II patients undergoing total hip replacement under epidural anesthesia were randomized into two groups. In one group, the patients were given epidural administration of morphine 15 min before operation at 4 mg (in 10 ml normal saline) and for 48 h after the operation at 80 microg/h, while those in the other group received epidural injection of the same amount of normal saline before operation and 0.15% ropivacaine 2.0 ml/h for 48 h in the same manner after operation. Blood samples were taken before anesthesia (T(0)), at the end of operation (T(1)), and 24 h and 48 h after operation (T(2) and T(3)) for determination of plasma IL-6 and D-dimer levels.
  
  
  RESULTS
  In both groups plasma IL-6 and D-dimer levels showed significant increase at T(1), T(2) and T(3) in comparison with those at T(0), and their levels were significantly lower in morphine group than in ropivacaine group at T(1), T(2) and T(3).
  
  
  CONCLUSIONS
  Epidural morphine can lower plasma IL-6 and D-dimer levels and correct blood hypercoagulability in patients undergoing total hip replacement.
authors.affiliation: Department of Anesthesia, People's Hospital of Guangdong Province, Guangzhou 510080, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Gang-jian
authors.initials: GJ
authors.lastname: Luo
authors.forename: Pai-chong
authors.initials: PC
authors.lastname: Lin
authors.forename: Pei-qing
authors.initials: PQ
authors.lastname: Liu
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D007268:Injections, Epidural; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D019990:Perioperative Care; D011184:Postoperative Period
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6; C036309:fibrin fragment D; D009020:Morphine