title: [Azathioprine-associated interstitial pneumonitis].
abstract: Azathioprine-associated interstitial pneumonitis. The early hypersensitivity reaction and the late bone marrow depression are well known side effects of the azathioprine; the interstitial pneumonia is a rare complication. A 40-year old male patient was treated with azathioprine due to extensive ulcerative colitis for ten years. He complained seven days of fever, cough and catarrhal signs, without the symptoms of active colitis. The opportunistic infections were ruled out. Chest X-ray, CT and lung biopsy proved the presence of interstitial inflammation. The azathioprine therapy was discontinued as the potential source of the pulmonary infiltrate. As a result of steroid therapy, as well as emergency unit care, the pulmonary infiltrates decreased gradually. Three months later his ulcerative colitis relapsed, for this an ileo-anal pouch surgery was done. In case of atypical pneumonia, without proven opportunistic infection, azathioprine-associated interstitial pneumonitis may be present, which heal after cessation of the drug.
authors.affiliation: Szegedi Tudományegyetem, Szent-Györgyi Albert Orvos- és Gyógyszerésztudományi Centrum, Altalános Orvostudományi Kar, Szeged I. Belgyógyászati Klinika. agyferi@in1st.szote.u-szeged.hu
authors.forename: Ferenc
authors.initials: F
authors.lastname: Nagy
authors.forename: Tamás
authors.initials: T
authors.lastname: Molnár
authors.forename: Eva
authors.initials: E
authors.lastname: Makula
authors.forename: Ildikó
authors.initials: I
authors.lastname: Kiss
authors.forename: Péter
authors.initials: P
authors.lastname: Milassin
authors.forename: Eva
authors.initials: E
authors.lastname: Zöllei
authors.forename: László
authors.initials: L
authors.lastname: Tiszlavicz
authors.forename: János
authors.initials: J
authors.lastname: Lonovics
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011859:Radiography
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine