title: Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation.
abstract: We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation. The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.
authors.affiliation: Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av. Pío XII 36,31008 Pamplona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Quincoces
authors.forename: Iván
authors.initials: I
authors.lastname: Peñuelas
authors.forename: Marta
authors.initials: M
authors.lastname: Valero
authors.forename: Patricia
authors.initials: P
authors.lastname: Serra
authors.forename: María
authors.initials: M
authors.lastname: Collantes
authors.forename: Josep
authors.initials: J
authors.lastname: Martí-Climent
authors.forename: Javier
authors.initials: J
authors.lastname: Arbizu
authors.forename: María José
authors.initials: MJ
authors.lastname: García-Velloso
authors.forename: José Angel
authors.initials: JA
authors.lastname: Richter
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D002851:Chromatography, High Pressure Liquid; D008715:Methionine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008745:Methylation; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline