A new total synthesis of porritoxin.
A concise and efficient total synthesis of the phytotoxin porritoxin is described. The key step of the synthesis is based upon a Parham cyclization methodology which enables the creation of the lactam unit embedded in the title compound framework with the concomitant formation of the tethered hydroxyakyl chain.
Moreau
Anne
A
Laboratoire de Chimie Organique Physique, UMR 8009 Chimie Organique et Macromoléculaire, Université des Sciences et technologies de Lille, Bâtiment C3(2), F-59655 Villeneuve d'Ascq Cedex, France.
Lorion
Magali
M
Couture
Axel
A
Deniau
Eric
E
Grandclaudon
Pierre
P
D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D054833:Isoindoles; D015394:Molecular Structure
D007211:Indoles; D054833:Isoindoles; C466610:porritoxin