title: NDR kinases regulate essential cell processes from yeast to humans.
abstract: Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components of pathways that control important cellular processes, such as morphological changes, mitotic exit, cytokinesis, cell proliferation and apoptosis. Recent progress has shed light on the mechanisms that underlie the regulation and function of the NDR family members. Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hergovich
authors.forename: Mario R
authors.initials: MR
authors.lastname: Stegert
authors.forename: Debora
authors.initials: D
authors.lastname: Schmitz
authors.forename: Brian A
authors.initials: BA
authors.lastname: Hemmings
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology
chemical_list: D017346:Protein Serine-Threonine Kinases; C496014:STK38L protein, human