G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits.
Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis.
Hasegawa
Hiroshi
H
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Takano
Hiroyuki
H
Ohtsuka
Masashi
M
Ueda
Kazutaka
K
Niitsuma
Yuriko
Y
Qin
Yingjie
Y
Tadokoro
Hiroyuki
H
Shiomi
Masashi
M
Komuro
Issei
I
D000818:Animals; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D009203:Myocardial Infarction / Q000517:prevention & control*; D011817:Rabbits / Q000378:metabolism*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
D008055:Lipids; D016179:Granulocyte Colony-Stimulating Factor