Lipid rafts: membrane triage centers.
Both biochemical and live cell imaging studies suggest the existence of lipid rafts, specialized membrane microdomains that promote interaction among signaling molecules. Although their composition is still poorly understood, these highly dynamic domains are enriched in cholesterol, sphingolipids, and particular groups of proteins. The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear.
Wang
Xiao-Qi
XQ
Department of Dermatology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Chicago, IL 60611, USA.
Paller
Amy S
AS
D066246:ErbB Receptors / Q000378:metabolism*; D005679:G(M3) Ganglioside / Q000502:physiology; D006801:Humans; D051861:Kangai-1 Protein / Q000502:physiology; D008024:Ligands; D021962:Membrane Microdomains / Q000502:physiology*; D047392:beta-Cyclodextrins / Q000494:pharmacology
D005679:G(M3) Ganglioside; D051861:Kangai-1 Protein; D008024:Ligands; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D066246:ErbB Receptors