Successful treatment of Candida parapsilosis mural endocarditis with combined caspofungin and voriconazole.
BACKGROUND
Fungal mural endocarditis is a rare entity in which the antemortem diagnosis is seldom made. Seven cases of mural endocarditis caused by Candida spp. have been collected from literature and six of these patients died after treatment with amphotericin B.


METHODS
We report a case of mural endocarditis diagnosed by transesophageal echocardiogram and positive blood cultures to Candida parapsilosis. Because blood cultures continued to yield C. parapsilosis despite caspofungin monotherapy, treatment with voriconazole was added.


CONCLUSIONS
This is the first description of successful treatment of C. parapsilosis mural endocarditis with caspofungin and voriconazole.
López-Ciudad
Víctor
V
Intensive Care Unit, Hospital Santa María Madre-Complejo Hospitalario de Ourense, Ourense, Spain. victor.jose.lopez.ciudad@sergas.es
Castro-Orjales
María J
MJ
León
Cristóbal
C
Sanz-Rodríguez
César
C
de la Torre-Fernández
María J
MJ
Pérez de Juan-Romero
Miguel A
MA
Collell-Llach
María D
MD
Díaz-López
María D
MD
D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology*; D000077336:Caspofungin; D004359:Drug Therapy, Combination; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole