title: Effect of discontinuing of laronidase in a patient with mucopolysaccharidosis type I.
abstract: We present a patient on enzyme replacement therapy who showed rapid deterioration when laronidase was discontinued owing to pregnancy.
authors.affiliation: Willink Biochemical Genetics Unit Royal Manchester, Children's Hospital, M27 4HA, Manchester, UK.
authors.forename: A T
authors.initials: AT
authors.lastname: Anbu
authors.forename: J
authors.initials: J
authors.lastname: Mercer
authors.forename: J E
authors.initials: JE
authors.lastname: Wraith
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007068:Iduronidase / Q000627:therapeutic use*; D008059:Mucopolysaccharidosis I / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D007068:Iduronidase