title: Mastectomy or breast conserving surgery? Factors affecting type of surgical treatment for breast cancer--a classification tree approach.
abstract: BACKGROUND
  A critical choice facing breast cancer patients is which surgical treatment--mastectomy or breast conserving surgery (BCS)--is most appropriate. Several studies have investigated factors that impact the type of surgery chosen, identifying features such as place of residence, age at diagnosis, tumor size, socio-economic and racial/ethnic elements as relevant. Such assessment of "propensity" is important in understanding issues such as a reported under-utilisation of BCS among women for whom such treatment was not contraindicated. Using Western Australian (WA) data, we further examine the factors associated with the type of surgical treatment for breast cancer using a classification tree approach. This approach deals naturally with complicated interactions between factors, and so allows flexible and interpretable models for treatment choice to be built that add to the current understanding of this complex decision process.
  
  
  METHODS
  Data was extracted from the WA Cancer Registry on women diagnosed with breast cancer in WA from 1990 to 2000. Subjects' treatment preferences were predicted from covariates using both classification trees and logistic regression.
  
  
  RESULTS
  Tumor size was the primary determinant of patient choice, subjects with tumors smaller than 20 mm in diameter preferring BCS. For subjects with tumors greater than 20 mm in diameter factors such as patient age, nodal status, and tumor histology become relevant as predictors of patient choice.
  
  
  CONCLUSIONS
  Classification trees perform as well as logistic regression for predicting patient choice, but are much easier to interpret for clinical use. The selected tree can inform clinicians' advice to patients.
authors.affiliation: School of Finance and Applied Statistics, Australian National University, Canberra ACT, 0200, Australia. michael.martin@anu.edu.au
authors.forename: Michael A
authors.initials: MA
authors.lastname: Martin
authors.forename: Ramona
authors.initials: R
authors.lastname: Meyricke
authors.forename: Terry
authors.initials: T
authors.lastname: O'Neill
authors.forename: Steven
authors.initials: S
authors.lastname: Roberts
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000601:surgery; D018275:Carcinoma, Lobular / Q000401:mortality / Q000601:surgery; D003663:Decision Trees; D005260:Female; D006801:Humans; D016015:Logistic Models; D008408:Mastectomy / Q000523:psychology / Q000706:statistics & numerical data*; D015412:Mastectomy, Segmental / Q000523:psychology / Q000706:statistics & numerical data*; D008875:Middle Aged; D015999:Multivariate Analysis; D017060:Patient Satisfaction; D012372:ROC Curve; D012042:Registries; D012189:Retrospective Studies; D047368:Tumor Burden; D014904:Western Australia