title: A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.
abstract: Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.
authors.affiliation: Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Bullido
authors.forename: Ana
authors.initials: A
authors.lastname: Martínez-García
authors.forename: María J
authors.initials: MJ
authors.lastname: Artiga
authors.forename: Jesús
authors.initials: J
authors.lastname: Aldudo
authors.forename: Isabel
authors.initials: I
authors.lastname: Sastre
authors.forename: Pedro
authors.initials: P
authors.lastname: Gil
authors.forename: Francisco
authors.initials: F
authors.lastname: Coria
authors.forename: David G
authors.initials: DG
authors.lastname: Muñoz
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hachinski
authors.forename: Ana
authors.initials: A
authors.lastname: Frank
authors.forename: Fernando
authors.initials: F
authors.lastname: Valdivieso
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D053327:Apolipoprotein E4; C071692:TAP2 protein, human