Asymmetric Friedel-Crafts addition of indoles to N-sulfonyl aldimines: a simple approach to optically active 3-indolyl-methanamine derivatives.
[reaction: see text] The enantioselective copper(II)-catalyzed Friedel-Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up to 96% ee) were achieved.
Jia
Yi-Xia
YX
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University Tianjin 300071, China.
Xie
Jian-Hua
JH
Duan
Hai-Feng
HF
Wang
Li-Xin
LX
Zhou
Qi-Lin
QL