title: Giant paraovarian myxoma.
abstract: We present an extremely rare case of a successfully operated giant (6700 g) paraovarian myxoma and uterus myomatosus in a 49-year-old woman. Preoperative examination (biochemical investigations, ultrasound and computed tomography scan) and perioperative findings did not identify a malignant tumor so that total abdominal hysterectomy/bilateral salpingo-oophorectomy and tumorectomy was chosen to treat the patient. Histologically, the tumor was clearly differentiated from the surrounding tissue. In solid regions there were spindle-shaped cells arranged in sheaves and within the profuse, well-vascularized myxomatous stroma there were star-shaped cells. Immunohistochemical analysis showed that tumor cells were positive to vimentin and smooth muscle actin. Electron microscopic analysis showed that tumor cells had ultrastructural characteristics that corresponded to cells in fibroma and thecoma in a profuse intercellular matrix, which confirmed the result of light microscopy.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Zagreb University, Sveti Duh Hospital Zagreb, Zagreb, Croatia. dubravko.habek@os.t-com.hr
authors.forename: Dubravko
authors.initials: D
authors.lastname: Habek
authors.forename: Branko
authors.initials: B
authors.lastname: Dmitrovic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Popovic
authors.forename: Matija
authors.initials: M
authors.lastname: Karsa
authors.forename: Valerija
authors.initials: V
authors.lastname: Blazicvic
authors.forename: Branko
authors.initials: B
authors.lastname: Rupcic
authors.forename: Mirna Erman
authors.initials: ME
authors.lastname: Vlahovic
authors.forename: Ksenija
authors.initials: K
authors.lastname: Marjanovic
mesh_terms: D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D009232:Myxoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology