The clinical impact of high frequency ventilation: review of the Cochrane meta-analyses.
Experimental work in animal models suggests that ventilation strategies using high frequency oscillatory ventilation or high frequency jet ventilation hold great promise in the prevention of lung injury in preterm infants. However, clinical trials of either modality demonstrate little clinical benefit and there are possibilities of adverse effects, including increased risk of intraventricular hemorrhage and poor neurological development.
Soll
R F
RF
Division of Neonatal Perinatal Medicine, Fletcher Allen Health Care, Burlington, Vermont 05401, USA. Roger.soll@vtmednet.org
D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D002543:Cerebral Hemorrhage / Q000209:etiology; D002908:Chronic Disease; D006612:High-Frequency Ventilation / Q000009:adverse effects; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D016032:Randomized Controlled Trials as Topic; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*