Fatty acids profile and antiinflammatory activity of Nonea setosa R. et S.
In order to verify the antiinflammatory properties of Nonea setosa R. et S. (Fam. Boraginaceae) and to identify the relevant active principles, aerial parts of this plant were extracted with increasing polarity solvents. The antiinflammatory activity was investigated by a bioassay-oriented fractionation using the inhibition of the croton oil-induced ear oedema in mice as an experimental model of inflammation. GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids.
Curini
Massimo
M
Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Perugia, Italy. curmax@unipg.it
Epifano
Francesco
F
Genovese
Salvatore
S
Menghini
Alessandro
A
Altinier
Gianmario
G
Tubaro
Aurelia
A
Menghini
Luigi
L
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D028082:Boraginaceae; D003436:Croton Oil; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005227:Fatty Acids / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D010936:Plant Extracts; D003436:Croton Oil