title: Pyrazolopyranopyrimidines as a class of anti-inflammatory agents.
abstract: Pyrazolopyranopyrimidines 6a-c and 8a-c were prepared from the reaction of compounds 4a-c or 7a-c with methylamine or ammonium hydroxide solutions. Treatment of compounds 6a-c or 8a-c with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9a-c or 10a-c, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent anti-inflammatory activity.
authors.affiliation: Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: Magdy E A
authors.initials: ME
authors.lastname: Zaki
authors.forename: Hanan A
authors.initials: HA
authors.lastname: Soliman
authors.forename: Ola A
authors.initials: OA
authors.lastname: Hiekal
authors.forename: Aymn E
authors.initials: AE
authors.lastname: Rashad
mesh_terms: D064753:Ammonium Hydroxide; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004195:Disease Models, Animal; D006878:Hydroxides; D008297:Male; D008744:Methylamines; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D011720:Pyrazoles / Q000138:chemical synthesis; D011743:Pyrimidines / Q000138:chemical synthesis; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D006878:Hydroxides; D008744:Methylamines; D011720:Pyrazoles; D011743:Pyrimidines; D064753:Ammonium Hydroxide; D002351:Carrageenan; C027451:methylamine