14N nuclear quadrupole resonance of some sulfa drugs.
The 14N nuclear quadrupole double resonance spectra of different polymorphs of sulfanilamide, sulfadiazine, sulfamerazine and sulfamethazine have been measured and the 14N quadrupole coupling tensors have been determined. The obtained 14N spectra are compared with those of other sulfa drugs like sulfathiazole. It is shown that different polymorphs can be easily discriminated. The application of this technique for non-destructive analysis, polymorph determination and quality control in the production of pharmaceuticals is stressed.
Blinc
Robert
R
J. Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia. robert.blinc@ijs.si
Seliger
Janez
J
Zidansek
Aleksander
A
Zagar
Veselko
V
Milia
Fani
F
Robert
Hector
H
D000890:Anti-Infective Agents / Q000737:chemistry*; D015394:Molecular Structure; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D013411:Sulfadiazine / Q000737:chemistry; D013416:Sulfamerazine / Q000737:chemistry; D013418:Sulfamethazine / Q000737:chemistry; D013424:Sulfanilamides / Q000737:chemistry*
D000890:Anti-Infective Agents; D009587:Nitrogen Isotopes; D013424:Sulfanilamides; D013411:Sulfadiazine; D013418:Sulfamethazine; D013416:Sulfamerazine