[The effects of inhaled corticoids on bone density in asthmatic children].
OBJECTIVE
To evaluate bone status of asthmatic children on chronic inhaled corticoid therapy.


METHODS
Bone densitometry was performed by Quantitative ultrasound (QUS) of the distal radius in 74 asthmatic children, evaluating Z-score; serum levels of 25 hydroxyvitamin D were measured in 10 cases.


RESULTS
28 of 74 children had osteopenia, defined as Z scores lower than -1. Statistic analyzes showed a significant correlation (p <0.05) of osteopenia with the duration of inhaled corticoid therapy (CSI), the absence of correlation with the dose of CSI, age, sex, severity step and duration of the disease. 25 hydroxyvitamin D was low in 8 of the 10 cases with osteopenia. Osteopenia was present in 7 children who were not under CSI, but have received multiple trials of oral corticoids for severe exacerbations.


CONCLUSIONS
Osteopenia was present in 52% of children that were under inhaled corticoids for more than 12 months and it correlated with the duration of CSI, but not with the daily dose. Systemic corticoid use is a significant cause of osteopenia in asthmatic children.
Goţia
Stela
S
Universitatea de Medicină şi Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Clinica a II-a Pediatric.
Rusu
Tania
T
Badiu
Irina
I
Murgu
Alina
A
Rugină
Aurica
A
Ioniuc
Ileana
I
D000280:Administration, Inhalation; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011884:Radius / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D050071:Bone Density Conservation Agents; D014807:Vitamin D; C104450:25-hydroxyvitamin D