title: Effect of arginine vasopressin in the nucleus raphe magnus on antinociception in the rat.
abstract: Previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the nucleus raphe magnus (NRM) of the rat. Microinjection of AVP into the NRM increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH2)5Tyr(Et)DAVP decreased the pain threshold. Pain stimulation elevated AVP concentration in the NRM perfuse liquid. NRM pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the NRM. The data suggest that AVP in the NRM is involved in antinociception.
authors.affiliation: Institute for Pharmaceutical and Medicinal Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529000, China. yj6676@yahoo.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Chen
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Liu
authors.forename: Cao-You
authors.initials: CY
authors.lastname: Song
authors.forename: Cheng-Hai
authors.initials: CH
authors.lastname: Wang
authors.forename: Bao-Cheng
authors.initials: BC
authors.lastname: Lin
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D008845:Microinjections; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017483:Receptors, Vasopressin / Q000378:metabolism; D013997:Time Factors
chemical_list: D000700:Analgesics; D065092:Antidiuretic Hormone Receptor Antagonists; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; C068622:argipressin,(1-mercaptocyclohexaneacetic acid)(1)-O-ethyl-Tyr(2)-