Background pathology of the common marmoset (Callithrix jacchus) in toxicological studies.
Two hundred common marmosets (Callithrix jacchus) from control groups (100 males, 100 females) of toxicological studies were examined histopathologically to evaluate the spectrum of spontaneous lesions in this species. Frequent findings were extramedullary hematopoiesis affecting adrenal glands, liver, kidney and spleen, cystic Brunner's glands in the duodenum, acute or subacute inflammation in the large intestine and gall bladder, renal mineralization and pigmentation, hepatic Ito-cell vacuolation, microgranuloma and glycogen storage, pituitary cysts, C-cell hyperplasia and lymphocytic foci of the thyroid gland, luteal hyperplasia of the ovary and inflammatory cell foci in various organs.
Kaspareit
J
J
Department of Pathology, Covance Laboratories, Kesselfeld 29, 48163 Münster, Germany. joachim.kaspareit@covance.com
Friderichs-Gromoll
S
S
Buse
E
E
Habermann
G
G
D000208:Acute Disease; D000818:Animals; D002144:Callithrix / Q000502:physiology; D041881:Cholecystitis, Acute / Q000453:epidemiology / Q000473:pathology; D004378:Duodenal Diseases / Q000453:epidemiology / Q000473:pathology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000473:pathology; D005858:Germany / Q000453:epidemiology; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D007420:Intestine, Large / Q000473:pathology; D007674:Kidney Diseases / Q000453:epidemiology / Q000473:pathology; D008107:Liver Diseases / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology / Q000473:pathology*; D010900:Pituitary Diseases / Q000453:epidemiology / Q000473:pathology; D013959:Thyroid Diseases / Q000453:epidemiology / Q000473:pathology; D018675:Toxicity Tests