Once-daily therapies for the treatment of HIV infection.
For patients initiating antiretroviral therapy, there are several well-tolerated once-daily regimens from which to choose. Once-daily antiretroviral therapy may be ideal for patient adherence and convenience. However, results of a few recent clinical trials exploring new once-daily regimens have shown that one cannot assume that any three-drug combination will be successful. Once-daily therapy options for treatment-experienced patients are more limited but may be successful depending on prior antiretroviral treatment exposure and resistance mutations. Current approaches to once-daily therapy include simplifying successful regimens and investigating novel antiretroviral agents with long half-lives.
Tashima
Karen T
KT
The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA. ktashima@lifespan.org
Mitty
Jennifer Adelson
JA
D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors