Stabilizers and destabilizers controlling cell cycle oscillators.
Various destabilizing factors of the ubiquitin system contribute to the synchrony and unidirectionality of the cell cycle clock by finely tuning the activity of various CDKs. The recent findings of hierarchical and connected waves of cyclin stabilizers highlight the complexity of this network.
Guardavaccaro
Daniele
D
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.
Pagano
Michele
M
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*; D014452:Ubiquitins / Q000502:physiology*
D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes; D018844:Cyclin-Dependent Kinases