title: A fungicidal monoclonal antibody protects against murine invasive candidiasis.
abstract: Mice infected by Candida albicans and treated with monoclonal antibody C7 survived longer than saline-treated animals. A prozone-like effect was observed. The in vitro candidacidal activity of macrophages was strongly enhanced when C. albicans was opsonized by C7 and complete murine serum was present.
authors.affiliation: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Apartado 644, E-48080 Bilbao, Vizcaya, Spain. mariajesus.sevilla@ehu.es
authors.forename: María J
authors.initials: MJ
authors.lastname: Sevilla
authors.forename: Beatriz
authors.initials: B
authors.lastname: Robledo
authors.forename: Aitor
authors.initials: A
authors.lastname: Rementeria
authors.forename: María D
authors.initials: MD
authors.lastname: Moragues
authors.forename: José
authors.initials: J
authors.lastname: Pontón
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000517:prevention & control*; D005260:Female; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis
chemical_list: D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal