title: [A case of resistant pulmonary and cerebral aspergillosis successfully treated with voriconazole].
abstract: Invasive pulmonary aspergillosis (IPA) is the most common fungal pulmonary infection in immunocompromised patients. In this disease, it is hard to diagnose, it's therapy process is variable and mortality is high. Prognosis is even worse in the cases which have cerebral aspergillosis. The patient was following up as a diagnosis of usual interstitial pneumonia and treating with corticosteroids and azothiopurine. Patient attended our clinic with headache and lose of vision. IPA and cerebral aspergillosis was the diagnosis as his examinations. Amphotericin B lipid complex treatment were given because of pulmonary and cerebral aspergillosis. Voriconazole was the second therapy because of the no response. Voriconazole is more effective in cerebral aspergillosis and treated this patient successfully.
authors.affiliation: Department of Chest Disease, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
authors.forename: Eyüp Sabri
authors.initials: ES
authors.lastname: Uçan
authors.forename: Vildan
authors.initials: V
authors.lastname: Avkan Oğuz
authors.forename: Ozkan
authors.initials: O
authors.lastname: Güngör
authors.forename: Aşkin
authors.initials: A
authors.lastname: Gülşen
authors.forename: Nurbanu
authors.initials: N
authors.lastname: Uğural Sezak
authors.forename: Kemal Can
authors.initials: KC
authors.lastname: Tertemiz
authors.forename: Emel
authors.initials: E
authors.lastname: Ceylan
authors.forename: Aydanur
authors.initials: A
authors.lastname: Kargi
authors.forename: Pinar
authors.initials: P
authors.lastname: Balci
authors.forename: Emel
authors.initials: E
authors.lastname: Ada
authors.forename: Aydin
authors.initials: A
authors.lastname: Sanli
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D011743:Pyrimidines / Q000627:therapeutic use; D013687:Telencephalon; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole