Co-distribution of the cannabinoid CB1 receptor and the 5-HT transporter in the rat amygdale.
Cannabis sometimes causes dysphoria rather than euphoria; however, evidence relating to the interaction between the cannabinoid and 5-hydroxtryptamine (5-HT) systems is limited, especially in areas of the brain such as the amygdale. Here we report that cannabinoid CB(1) receptors and 5-HT transporter proteins are co-distributed in the amygdale, suggesting the possibility that activation of cannabinoid CB(1) receptors might cause a reduction in 5-HT release, similar to its effect on other neurotransmitters, thereby resulting in dysphoria.
Ashton
John C
JC
Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand.
Darlington
Cynthia L
CL
Smith
Paul F
PF
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D008297:Male; D010200:Panic / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
D043884:Receptor, Cannabinoid, CB1; D050486:Serotonin Plasma Membrane Transport Proteins