title: Integration of macromolecular diffraction data using radial basis function networks.
abstract: This paper presents a novel approach for intensity calculation of X-ray diffraction spots based on a two-stage radial basis function (RBF) network. The first stage uses pre-determined reference profiles from a database as basis functions in order to locate the diffraction spots and identify any overlapping regions. The second-stage RBF network employs narrow basis functions capable of local modifications of the reference profiles leading to a more accurate observed diffraction spot approximation and therefore accurate determination of spot positions and integrated intensities.
authors.affiliation: UMIST, Department of Electrical Engineering and Electronics, PO Box 88, Manchester M60 1QD, UK.
authors.forename: B
authors.initials: B
authors.lastname: Pokrić
authors.forename: N M
authors.initials: NM
authors.lastname: Allinson
authors.forename: J R
authors.initials: JR
authors.lastname: Helliwell