title: Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach.
abstract: OBJECTIVE
  A retrospective review of primary chemoradiotherapy (CRT) for adenoid cystic carcinoma (ACC) was performed to determine if CRT might be considered as an alternative to radiotherapy and/or definitive surgery.
  
  
  METHODS
  All treatment-naive patients with ACC of the head and neck who were treated with definitive primary chemoradiotherapy using carboplatinum and paclitaxel at Dana-Farber Cancer Institute in 2000 through 2004 were identified. Information on site, stage, presenting symptoms, performance status, treatment, toxicity, and follow up were collected and tabulated for review.
  
  
  RESULTS
  Five patients were identified with previously untreated ACC of the head and neck who received primary carboplatinum/paclitaxel CRT for unresectability or organ preservation. Patients had a median age of 41, 4 had primaries in the paranasal sinuses invading the base of skull and 1 had a transglottic laryngeal lesion. All patients completed a course of definitive chemoradiotherapy without treatment break. Grade 3 mucosal reactions developed during CRT in all patients. With a median follow-up of 36 months (range, 20-43) all patients have local regional control; 1 patient developed distant metastases at 7 months and is alive at 20 months.
  
  
  CONCLUSIONS
  Preliminary data suggest that carboplatinum/paclitaxel based CRT for ACC provides local regional control and is a potential alternative to surgery or radiotherapy for patients with locally advanced ACC. Carboplatinum/paclitaxel based CRT warrants further study.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Robert I
authors.initials: RI
authors.lastname: Haddad
authors.forename: Marshall R
authors.initials: MR
authors.lastname: Posner
authors.forename: Paul M
authors.initials: PM
authors.lastname: Busse
authors.forename: Charles M
authors.initials: CM
authors.lastname: Norris
authors.forename: Laura A
authors.initials: LA
authors.lastname: Goguen
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Wirth
authors.forename: Russell
authors.initials: R
authors.lastname: Blinder
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Krane
authors.forename: Roy B
authors.initials: RB
authors.lastname: Tishler
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D016190:Carboplatin; D017239:Paclitaxel