Nandrolone decanoate impairs exercise-induced cardioprotection: role of antioxidant enzymes.
The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing the antioxidant enzyme activities. Here, we investigated the impact of exercise and high doses of the AAS nandrolone decanoate (DECA), 10 mgkg(-1) body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events.
Chaves
Elen Aguiar
EA
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil. chavesea@yahoo.com.br
Pereira-Junior
Pedro Paulo
PP
Fortunato
Rodrigo Soares
RS
Masuda
Masako Oya
MO
de Carvalho
Antônio Carlos Campos
AC
de Carvalho
Denise Pires
DP
Oliveira
Marcus F
MF
Nascimento
José Hamilton Matheus
JH
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D002316:Cardiotonic Agents / Q000037:antagonists & inhibitors*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000517:prevention & control*; D009249:NADP / Q000378:metabolism; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D045930:Anabolic Agents; D002316:Cardiotonic Agents; D009249:NADP; D009277:Nandrolone; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D000077603:Nandrolone Decanoate