Molecular properties of P2X receptors.
P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range of phenotypes. This review aims to give an account of recent work on the molecular basis of the properties of P2X receptors. In particular, to consider emerging information on the assembly of P2X receptor subunits, channel regulation and desensitisation, targeting, the molecular basis of drug action and the functional contribution of P2X receptors to physiological processes.
Roberts
Jonathan A
JA
Department of Cell Physiology & Pharmacology, Medical Sciences Building, University of Leicester, Leicester, LE1 9HN, UK.
Vial
Catherine
C
Digby
Helen R
HR
Agboh
Kelvin C
KC
Wen
Hairuo
H
Atterbury-Thomas
Amelia
A
Evans
Richard J
RJ
D000255:Adenosine Triphosphate / Q000737:chemistry* / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D051379:Mice; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D018048:Receptors, Purinergic P2 / Q000737:chemistry* / Q000378:metabolism*; D058476:Receptors, Purinergic P2X2; D013329:Structure-Activity Relationship
C546401:P2RX2 protein, human; C546402:P2rx2 protein, mouse; D018048:Receptors, Purinergic P2; D058476:Receptors, Purinergic P2X2; D000255:Adenosine Triphosphate