title: ALDH2 promoter polymorphism has no effect on the risk for alcoholism.
abstract: OBJECTIVE
  To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism.
  
  
  METHODS
  Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed.
  
  
  RESULTS
  There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms.
  
  
  CONCLUSIONS
  These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.
authors.affiliation: National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kimura
authors.forename: Shigeko
authors.initials: S
authors.lastname: Kimura
authors.forename: Sachio
authors.initials: S
authors.lastname: Matsushita
authors.forename: Haruo
authors.initials: H
authors.lastname: Kashima
authors.forename: Susumu
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012016:Reference Values; D012306:Risk
chemical_list: C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial