Devic disease with brainstem lesions.
We describe a patient who suffered from an unusually severe form of neuromyelitis optica with a hyperacute time-course evolution requiring mechanical ventilation within 3 days. The patient died after 72 days and autopsy showed major spinal cord, optic nerve, and brainstem necrosis, and multifocal necrotic lesions on the cerebellum and cerebral white matter.
Chalumeau-Lemoine
Ludivine
L
Medical Reanimation Service, Pathology Department, Henri Mondor Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Créteil, France.
Chretien
Fabrice
F
Gaëlle Si Larbi
Anne
A
Brugieres
Pierre
P
Gray
Françoise
F
Brun-Buisson
Christian
C
Creange
Alain
A
D000208:Acute Disease; D001933:Brain Stem / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003128:Coma / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D005602:France; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000175:diagnosis* / Q000209:etiology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology; D011782:Quadriplegia / Q000209:etiology; D012121:Respiration, Artificial; D012133:Respiratory Paralysis / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology; D013687:Telencephalon / Q000473:pathology; D013997:Time Factors; D017211:Treatment Failure
D007166:Immunosuppressive Agents