Fecal elastase-1: utility in pancreatic function in cystic fibrosis.
Early detection and management of pancreatic insufficiency is essential to optimize health and outcomes in cystic fibrosis patients. The gold standard measures for assessment of pancreatic function are direct pancreatic stimulation tests, which have numerous limitations. Estimation of fecal elastase-1 level to determine pancreatic function is an attractive alternative as the test is simple, rapid, cost-effective and easy to perform even in children. This review summarizes the data from studies reflecting the validity, limitation and advantages of fecal elastase-1 in assessing pancreatic function in cystic fibrosis patients.
Daftary
Ameet
A
Department of Pulmonary Medicine and Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ameet.daftary@cchmc.org
Acton
James
J
Heubi
James
J
Amin
Raouf
R
D015415:Biomarkers / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D004796:Clinical Enzyme Tests; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications / Q000175:diagnosis*; D005243:Feces / Q000201:enzymology*; D006801:Humans; D010196:Pancreatic Elastase; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers; D002352:Carrier Proteins; D010196:Pancreatic Elastase; C017130:cholesterol-binding protein