title: Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.
abstract: Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome. It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome. We present a case of hypereosinophilia related to zafirlukast therapy. The patient did not fulfil criteria for Churg-Strauss syndrome. Symptoms and laboratory findings improved after zafirlukast was removed.
authors.affiliation: Allergy Department. Hospital Universitario La Fe. Valencia, Spain. galima@ono.com
authors.forename: J
authors.initials: J
authors.lastname: Reyes-Balaguer
authors.forename: D
authors.initials: D
authors.lastname: Hernández de Rojas
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000276:immunology; D001249:Asthma / Q000188:drug therapy*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; C062735:zafirlukast