title: T-cell gamma/delta hepatosplenic lymphoma - prolonged remission induced by aggressive first line treatment.
abstract: T-cell gamma/delta hepatosplenic lymphoma is a primary extranodal lymphoma, distinct from other T/LGL lymphomas. The clinical course is aggressive, and despite use of the multiagent chemotherapy and young age of the patients, the median survival is less than 1 year. Curability of this disease is still uncertain. We reported a case of the successful intensive treatment with splenectomy, chemotherapy a first line autologous stem cell transplant. High intensity cytarabine- platinum containing regimen (EDHAP) may overcome primary resistance to conventional alkylating agents.
authors.affiliation: Department of Hemato-oncology, Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Vít
authors.initials: V
authors.lastname: Procházka
authors.forename: Tomás
authors.initials: T
authors.lastname: Papajík
authors.forename: Marie
authors.initials: M
authors.lastname: Jarosová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Pikalová
authors.forename: Karel
authors.initials: K
authors.lastname: Indrák
authors.forename: Martin
authors.initials: M
authors.lastname: Tichý
authors.forename: Ladislava
authors.initials: L
authors.lastname: Kucerová
authors.forename: Frantisek
authors.initials: F
authors.lastname: Fakan
authors.forename: Milan
authors.initials: M
authors.lastname: Bílý
authors.forename: David
authors.initials: D
authors.lastname: Starostka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012074:Remission Induction; D013160:Splenic Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta