Antiproliferative activity of berberine in vitro and in vivo.
Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.
Letasiová
Silvia
S
Department of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. silvia.letasiova@stuba.sk
Jantová
Sona
S
Múcková
Marta
M
Theiszová
Marica
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D008546:Melanoma, Experimental; D051379:Mice; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D001599:Berberine