title: Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.
abstract: The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.
authors.affiliation: Departamento de Química Orgânica-PQO, Instituto de Química, Universidade Federal Fluminense, 24020-150, Niterói, Rio de Janeiro, Brazil.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Jorqueira
authors.forename: Robson M
authors.initials: RM
authors.lastname: Gouvêa
authors.forename: Vitor F
authors.initials: VF
authors.lastname: Ferreira
authors.forename: Milton N
authors.initials: MN
authors.lastname: da Silva
authors.forename: Maria C B V
authors.initials: MC
authors.lastname: de Souza
authors.forename: Aline A
authors.initials: AA
authors.lastname: Zuma
authors.forename: Danielle F B
authors.initials: DF
authors.lastname: Cavalcanti
authors.forename: Humberto P
authors.initials: HP
authors.lastname: Araújo
authors.forename: Dilvani O
authors.initials: DO
authors.lastname: Santos
authors.forename: Saulo C
authors.initials: SC
authors.lastname: Bourguignon
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006131:Growth Inhibitors / Q000494:pharmacology*; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development*; D014709:Vero Cells
chemical_list: D000981:Antiprotozoal Agents; D006131:Growth Inhibitors; D009285:Naphthoquinones; C014638:beta-lapachone; C415043:alpha-lapachone