title: [Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study].
abstract: OBJECTIVE
  In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T-344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T-47C, T164I), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents.
  
  
  METHODS
  The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study.
  
  
  RESULTS
  In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p = 0.0403), AGT (M235T) (p = 0.0002), and REN (G2646A) (p = 0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents.
  
  
  CONCLUSIONS
  This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.
authors.affiliation: Department of Preventive Medicine, College of Medicine, Yonsei University.
authors.forename: Il
authors.initials: I
authors.lastname: Suh
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dong-Jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Nam Wook
authors.initials: NW
authors.lastname: Hur
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007723:Korea; D011446:Prospective Studies
chemical_list: D005819:Genetic Markers