Overexpression of pituitary tumor-transforming gene-1 in hepatocellular carcinoma.
OBJECTIVE
Pituitary tumor-transforming gene-1, a recently identified proto-oncogene, was reported to be highly expressed in various tumors, such as tumors of the pituitary gland, adrenal gland, colon, ovary, endometrium, uterus, and kidney. The purpose of this study was to investigate the clinicopathologic significance of PTTG1 expression in hepatocellular carcinoma.


METHODS
Expression of PTTG1 mRNA was evaluated by RT-PCR in 147 HCCs and 103 paired nontumorous liver tissues.


RESULTS
PTTG1 was found overexpressed in 80 of 147 (61%) HCCs. Overexpression of PTTG1 correlated with alpha-fetoprotein elevation (p<0.022) and higher tumor stage (stage IIIB-IV) tumors (p<0.009), but not with tumor grade, size, and survival.


CONCLUSIONS
The results show that PTTG1 is overexpressed frequently in HCC, and correlated high stage tumors, indicating that overexpression of PTTG1 plays a role in the development and progression of HCC.
Su
Min-Cheng
MC
Department of Pathology, Min-Sheng General Hospital, Taoyuan City, Taiwan, ROC.
Hsu
Hey-Chi
HC
Liu
Yu-Jung
YJ
Jeng
Yung-Ming
YM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009367:Neoplasm Staging; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000378:metabolism; D064249:Securin; D051176:beta Catenin / Q000235:genetics
C495270:CTNNB1 protein, human; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D064249:Securin; D051176:beta Catenin; C578002:pituitary tumor-transforming protein 1, human