title: Pathogenic T cells in cerebral malaria.
abstract: Malaria remains a major global health problem and cerebral malaria (CM) is one of the most serious complications of this disease. Recent years have seen important advances in our understanding of the pathogenesis of cerebral malaria. Parasite sequestration, a hallmark of this syndrome, is thought to be solely responsible for the pathological process. However, this phenomenon cannot explain all aspects of the pathogenesis of CM. The use of an animal model, Plasmodium berghei ANKA in mice, has allowed the identification of specific pathological components of CM. Although multiple pathways may lead to CM, an important role for CD8+ T cells has been clarified. Other cells, including platelets, and mediators such as cytokines also have an important role. In this review we have focused on the role of T cells, and discuss what remains to be studied to understand the pathways by which these cells mediate CM.
authors.affiliation: Department of Immunology, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, Paris, France. renia@cochin.inserm.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Potter
authors.forename: Marjorie
authors.initials: M
authors.lastname: Mauduit
authors.forename: Daniela Santoro
authors.initials: DS
authors.lastname: Rosa
authors.forename: Michèle
authors.initials: M
authors.lastname: Kayibanda
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Deschemin
authors.forename: Georges
authors.initials: G
authors.lastname: Snounou
authors.forename: Anne Charlotte
authors.initials: AC
authors.lastname: Grüner
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D016779:Malaria, Cerebral / Q000276:immunology*; D051379:Mice; D010962:Plasmodium berghei / Q000472:pathogenicity; D013045:Species Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology*