Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans.
OBJECTIVE
Search for plant compounds possessing anti-leukemic properties.


RESULTS
We have shown that 5-hydroxy-7-methoxy flavanone (pinostrobin) isolated from Polygonum lapathifolium ssp. nodosum quickly penetrates through cytoplasm to the cellular nucleus of the cultured cells, and gives intensive apoptotic response in stimulating leukemic cells in vitro. The number of apoptotic cells increased with the concentration of pinostrobin: 10 nM - 25% and 60%; 100 nM - 45% and 76%; 1 microm - 70% and 88% for Jurkat and HL60 cell lines, respectively


CONCLUSIONS
Pinostrobin may be considered as a good candidate for a leukemia chemopreventic agent.
Smolarz
Helena D
HD
Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland. smolarz@am.lublin.pl
Mendyk
Ewaryst
E
Bogucka-Kocka
Anna
A
Kocki
Janusz
J
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D019169:Jurkat Cells; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*
D000970:Antineoplastic Agents; D044950:Flavanones; D010936:Plant Extracts; C411294:pinostrobin