title: Nogo-66 receptor at the gap junctions between pituicytes of the rat.
abstract: Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior pituitary, which is densely packed with pituicytes, a special type of astrocyte, and is known to be rich in gap junctions. We were able to demonstrate with immunohistochemistry and immuno-electron microscopy abundant Nogo-66 receptor immunoreactive gap junctions between pituicytes. This study, together with our prior one, strongly suggests that the Nogo-66 receptor may play a role in regulating the function of the gap junctions.
authors.affiliation: Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China.
authors.forename: Ya-Zhou
authors.initials: YZ
authors.lastname: Wang
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Liu
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Si-Wei
authors.initials: SW
authors.lastname: You
authors.forename: Gong
authors.initials: G
authors.lastname: Ju
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000379:methods; D018031:Connexin 43 / Q000378:metabolism; D058851:GPI-Linked Proteins; D017629:Gap Junctions / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry / Q000379:methods; D016253:Microscopy, Immunoelectron / Q000379:methods; D009185:Myelin Proteins / Q000378:metabolism*; D000070816:Nogo Receptor 1; D010904:Pituitary Gland, Posterior / Q000166:cytology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D018031:Connexin 43; D058851:GPI-Linked Proteins; D009185:Myelin Proteins; D000070816:Nogo Receptor 1; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C486581:Rtn4r protein, rat