MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection.
This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV). Expression was examined immunohistochemically using specimens from 38 patients who underwent surgical treatment for CAV. Expression was found in 61% of samples. Thirteen of 15 well-differentiated but only two of eight poorly differentiated adenocarcinoma were positive (P=0.0352). MK-1 positivity tended to show significantly decreasing pT (P=0.0039), pN (P<or=0.001), and pStage (P=0.001). Multivariate analysis showed that MK-1 expression is an independent prognostic marker (P=0.0097) and Kaplan-Meier curves showed a significant relationship with increased overall survival (P=0.0137). These results suggest that MK-1 expression is a prognostic marker of CAV.
Hamada
Yoshihiro
Y
Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. cjz40250@rio.odn.ne.jp <cjz40250@rio.odn.ne.jp>
Nakayama
Yoshifuku
Y
Mizoguchi
Mikiro
M
Ikeda
Seiyo
S
Kuroki
Masahide
M
Iwasaki
Hiroshi
H
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D003138:Common Bile Duct Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000071858:Epithelial Cell Adhesion Molecule; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000706:statistics & numerical data; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models
D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule