title: Linezolid and human polymorphonuclear leukocyte function.
abstract: BACKGROUND
  To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function.
  
  
  METHODS
  Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid.
  
  
  RESULTS
  Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst.
  
  
  CONCLUSIONS
  Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.
authors.affiliation: Institute of Medicine, University of Bergen, Norway. are.nass@med.uib.no
authors.forename: Are
authors.initials: A
authors.lastname: Naess
authors.forename: Kristin
authors.initials: K
authors.lastname: Stenhaug Kilhus
authors.forename: Tone W
authors.initials: TW
authors.lastname: Nystad
authors.forename: Steinar
authors.initials: S
authors.lastname: Sørnes
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005434:Flow Cytometry; D006801:Humans; D000069349:Linezolid; D009504:Neutrophils / Q000502:physiology*; D023303:Oxazolidinones / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D016897:Respiratory Burst / Q000187:drug effects*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid