[Effect of Herba Lamiophlomis Rotata extract on rats blood conglomeration parameters by oral administration].
OBJECTIVE
To study the effect of Tibet medicine Herba Lamiophlomis Rotata exect (HLRE) on blood conglomeration parameters by oral administration.


METHODS
High dose (3 g/kg), middle dose (1.5 g/kg) and low dose (0.75 g/kg) of HLRE had been given orally in rats for 7, 14, 21 days. Blood samples were collected from common carotid artery and prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) were tested.


RESULTS
After 7 days, as compared to the control, the high, middle doses of HLRE induced significant TT reduction, and all doses of HLRE could induce significant hyperfibrinogenemia. But there was no change in PT and APTL. After 14 days, in all groups treated with HLRE, TT decreased and FIB increased. As compared to the control, only the high dose had significantly changes in TT and FIB. After 21 days, as compared to the control, TT of high and middle groups decreased and FIB of high group increased visibly. PT decurtation could also be seen in all groups. There was a decrease in TT paralleling an increase of fibrinogen in our study.


CONCLUSIONS
The aqueous extract of Herba Lamiophlomis Rotata orally administered in rats can increase the contents of FIB and shorten TT. The shorten of PT is found after treated with high dose for a long time. Hemostatic effect of HLRE has a dose-effect and time-effect relationship.
Li
Mao-xing
MX
Lanzhou General Hospital of PLA, Lanzhou 730050, China.
Jia
Zheng-ping
ZP
Shen
Tao
T
Zhang
Ru-xue
RX
Zhang
Hua-xin
HX
Li
Zhi-ying
ZY
D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D004305:Dose-Response Relationship, Drug; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry; D013997:Time Factors
D006490:Hemostatics; D010936:Plant Extracts