title: Effect of lung ventilation with 50% oxygen in air or nitrous oxide versus 100% oxygen on oxygenation index after cardiopulmonary bypass.
abstract: OBJECTIVE
  This study was designed to assess the use of 100% oxygen or 50% oxygen in air or nitrous oxide after cardiopulmonary bypass (CPB) on atelectasis, as evidenced by the oxygenation index (PaO2/F(I)O2), after coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Prospective, randomized clinical study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Thirty-six adult patients undergoing CABG surgery.
  
  
  METHODS
  Patients either received 50% O2 in air (50% O2 group), 50% O2 in N2O (50% N2O group), or 100% O2 (100% O2 group) after CPB.
  
  
  RESULTS
  Apart from demographic and perioperative clinical data, extubation time, mediastinal drainage, and pulmonary complications were also recorded. After CPB, arterial blood gases done at various time points until 3 hours postextubation and oxygenation index were calculated. No significant differences were noted in demographic and perioperative data except preoperative hemoglobin and fluid use. Significant deterioration in arterial oxygenation was noted in the 100% O2 group from the baseline value, whereas significant improvement was seen in the 50% O2 group at 4 time points from baseline value and at all time points from the 100% O2 group. After initial deterioration in oxygenation, no further change was evident in the 50% N2O group. Furthermore, there was a greater increase in the oxygenation index as compared with the 100% O2 group. Time to extubation was also longer in the 100% O2 group than the 50% O2 group.
  
  
  CONCLUSIONS
  Significant deterioration in arterial oxygenation and an increase in the extubation time occurred with the use of 100% O2 after CPB, whereas better oxygenation was evident with the use of 50% O2 in air.
authors.affiliation: Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India. pksinha@sctimst.ac.in
authors.forename: Prabhat Kumar
authors.initials: PK
authors.lastname: Sinha
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Neema
authors.forename: Koniparambil Pappu
authors.initials: KP
authors.lastname: Unnikrishnan
authors.forename: Praveen Kerala
authors.initials: PK
authors.lastname: Varma
authors.forename: Karunakaran
authors.initials: K
authors.lastname: Jaykumar
authors.forename: Ramesh Chandra
authors.initials: RC
authors.lastname: Rathod
mesh_terms: D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D001784:Blood Gas Analysis; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003327:Coronary Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000502:physiology*; D011183:Postoperative Complications; D011446:Prospective Studies; D001261:Pulmonary Atelectasis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D012121:Respiration, Artificial / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide; D010100:Oxygen