Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells.
Experimental evidences have confirmed that matrix metalloproteinases (MMPs) play a fundamental role in a wide variety of pathologic conditions and recent advances in medicinal chemistry approach to the design of MMP inhibitors with desired structural and functional properties. Among MMPs, MMP-9 has demonstrated to play a major role in the establishment of metastases and it is substantially increased in the majority of malignant tumors. Inhibition of MMP-9 is thought to have a therapeutic benefit to cancer. Results of this study present a novel synthetic MMP-9 inhibitor that downregulates MMP-9 expression level in HT1080, human fibrosarcoma cells.
Mendis
Eresha
E
Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
Kim
Moon-Moo
MM
Rajapakse
Niranjan
N
Kim
Se-Kwon
SK
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005780:Gelatin / Q000378:metabolism; D005944:Glucosamine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared
D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D005780:Gelatin; D020780:Matrix Metalloproteinase 9; D005944:Glucosamine