title: Expression of p27KIP1, p21WAF1 and p53 does not correlate with prognosis in node-negative invasive ductal carcinoma of the breast.
abstract: The expressions ofp27Kip1 (p27) and p21waf1 (p21) cyclin-dependent kinase inhibitors and p53 were examined in a series of 170 node-negative breast carcinomas (NNBCs) to evaluate their prognostic significance. Low nuclear (p27TN) and cytoplasmic (p27TC) p27 expressions were noted in 66% and 81% of NNBCs, respectively. p21 and p53 overexpressions were detected in 56% and 26%, respectively. Low p27TN was significantly associated with high grade (p=0.001), age < or = 50 years (p=0.01), negative hormone receptors (p<0.001), low p27TC (p<0.001) and p53 overexpression (p=0.02). Low p27TC was associated with negative hormone receptors (p<0.001). p53 overexpression was associated with high grade (p<0.001) and negative hormone receptors (p<0.001). p21 overexpression, although not correlated with the examined parameters, was associated with increased disease-free survival in univariate analysis. In multivariate analysis, p27TN, p27TC, p21 and p53 were not associated with disease-free survival or overall survival. These findings argue against the prognostic value of p27, p21 and p53 in NNBC.
authors.affiliation: Department of Pathology, University Hospital of Patras, Patras, Greece. hkourea@yahoo.com
authors.forename: Helen P
authors.initials: HP
authors.lastname: Kourea
authors.forename: Angelos K
authors.initials: AK
authors.lastname: Koutras
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Zolota
authors.forename: Irene
authors.initials: I
authors.lastname: Grimani
authors.forename: Evangelos
authors.initials: E
authors.lastname: Tzoracoeleftherakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Koukouras
authors.forename: George
authors.initials: G
authors.lastname: Fountzilas
authors.forename: Helen
authors.initials: H
authors.lastname: Gogas
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Kyriakou
authors.forename: Adamos
authors.initials: A
authors.lastname: Adamou
authors.forename: Haralambos P
authors.initials: HP
authors.lastname: Kalofonos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D050760:Cyclin-Dependent Kinase Inhibitor p27