title: Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule.
abstract: The synthesis of chiral cyclic oligo(4-beta-methyl)thiazolines is described; linear oligothiazolines were efficiently prepared by the iterative formation of a thiazoline ring and a two-directional block condensation, and construction of 24- to 36-membered cyclic oligothiazoline systems could be achieved by the head-to-tail cyclooligomerization of doubly deprotected linear fragments and subsequent thiazoline formation.
authors.affiliation: PRESTO, the Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Fu She
authors.initials: FS
authors.lastname: Han
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osajima
authors.forename: Mui
authors.initials: M
authors.lastname: Cheung
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D047028:Macrocyclic Compounds; D013844:Thiazoles