A case of interstitial pneumonia caused by bucillamine: a study using serological markers.
The patient was a 61-year-old man diagnosed with rheumatoid arthritis (RA) in 2001. He initially received treatment at a nearby clinic, but his condition could not be satisfactorily controlled. He subsequently consulted our hospital during the same year. Although his symptoms improved in response to treatment at our hospital, slight fever, cough, and then high fever and dyspnea subsequently developed. A diagnosis of interstitial pneumonia was made on the basis of findings of diagnostic imaging. The time course of changes in serological markers, including surfactant protein A (SP-A), surfactant protein D (SP-D), and KL-6, as well as markers of inflammatory reaction and lactate dehydrogenase was examined to determine the clinical significance of serological markers in the management of interstitial pneumonia.
Tanimura
Kazuhide
K
Rheumatic and Collagen Disease Center, Sapporo Yamanoue Hospital, 6-9-1-1 Yamanote, Nishi-ku, Sapporo 063-0006, Japan. k.tanimura@pep.ne.jp
Shimizu
Masato
M
Matsuhashi
Megumi
M
Shinohara
Masahide
M
Sagawa
Akira
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000951:Antigens, Neoplasm / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003545:Cysteine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000097:blood; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000951:Antigens, Neoplasm; D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D003545:Cysteine; C026535:bucillamine