title: Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin.
abstract: The efficacies of gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of pneumonic tularemia and compared with the efficacy of ciprofloxacin. The rate of relapse following dexamethasone treatment was also investigated. Mice were given 100 mg/kg of the antibiotic by oral administration twice daily for 14 days following an aerosol challenge. All three fluoroquinolones prevented disease during the treatment period, but significant failure rates occurred after the cessation of therapy. Both gatifloxacin and moxifloxacin were more effective than ciprofloxacin at reducing late mortality. Fluoroquinolones may therefore be considered useful candidates for the treatment of pneumonic tularemia.
authors.affiliation: DSTL Porton Down, Salisbury, Wiltshire SP4 OJQ, UK. jasteward@dstl.gov.uk
authors.forename: J
authors.initials: J
authors.lastname: Steward
authors.forename: T
authors.initials: T
authors.lastname: Piercy
authors.forename: M S
authors.initials: MS
authors.lastname: Lever
authors.forename: A J H
authors.initials: AJ
authors.lastname: Simpson
authors.forename: T J G
authors.initials: TJ
authors.lastname: Brooks
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D000077734:Gatifloxacin; D051379:Mice; D008807:Mice, Inbred BALB C; D000077266:Moxifloxacin; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D011804:Quinolines / Q000627:therapeutic use*; D014406:Tularemia / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D002939:Ciprofloxacin; D000077734:Gatifloxacin; D000077266:Moxifloxacin