title: New weapons in the war on worms: identification of putative mechanisms of immune-mediated expulsion of gastrointestinal nematodes.
abstract: Parasitic nematode infections of humans and livestock continue to impose a significant public health and economic burden worldwide. Murine models of intestinal nematode infection have proved to be relevant and tractable systems to define the cellular and molecular basis of how the host immune system regulates resistance and susceptibility to infection. While susceptibility to chronic infection is propagated by T helper cell type 1 cytokine responses (characterised by production of IL-12, IL-18 and interferon-gamma), immunity to intestinal-dwelling adult nematode worms is critically dependent on a type 2 cytokine response (controlled by CD4+T helper type 2 cells that secrete the cytokines IL-4, IL-5, IL-9 and IL-13). However, the immune effector mechanisms elicited by type 2 cytokines in the gut microenvironment that precipitate worm expulsion have remained elusive. This review focuses on new studies that implicate host intestinal epithelial cells as one of the dominant immune effector cells against this group of pathogens. Specifically, three recently identified type 2 cytokine-dependent pathways that could offer insights into the mechanisms of expulsion of parasitic nematodes will be discussed: (i) the intelectins, a new family of galactose-binding lectins implicated in innate immunity, (ii) the resistin-like molecules, a family of small cysteine-rich proteins expressed by multiple cell types, and (iii) cytokine regulation of intestinal epithelial cell turnover. Identifying how the mammalian immune response fights gastrointestinal nematode infections is providing new insights into host protective immunity. Harnessing these discoveries, coupled with identifying what the targets of these responses are within parasitic nematodes, offers promise in the design of a new generation of anti-parasitic drugs and vaccines.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Rosenthal 207, 3800 Spruce Street, Philadelphia, PA 19104, USA. dartis@vet.upenn.edu
authors.forename: David
authors.initials: D
authors.lastname: Artis
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000502:physiology; D058851:GPI-Linked Proteins; D006790:Host-Parasite Interactions; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000276:immunology* / Q000469:parasitology; D007413:Intestinal Mucosa / Q000276:immunology; D037102:Lectins / Q000276:immunology; D051379:Mice; D009349:Nematode Infections / Q000276:immunology* / Q000469:parasitology; D052243:Resistin / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014257:Trichuriasis / Q000276:immunology; D014258:Trichuris / Q000648:ultrastructure
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D052243:Resistin