Pharmacological modulation of the heat shock response.
Life presents a continuous series of stresses. Increasing the adaptation capacity of the organism is a long-term survival factor of various organisms and has become an attractive field of intensive therapeutic research. Induction of the heat shock response promotes survival after a wide variety of environmental stresses. Preclinical studies have proven that physiological and pharmacological chaperone inducers and co-inducers are an efficient therapeutic approach in different acute and chronic diseases. In this chapter, we summarize current knowledge of the current state of chaperone modulation and give a comprehensive list of the main drug candidates.
Soti
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Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
Csermely
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D000375:Aging; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D019610:Cytoprotection; D004574:Electromagnetic Fields; D005973:Glutamine / Q000494:pharmacology; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D018869:Heat-Shock Response / Q000187:drug effects*; D006801:Humans; D018832:Molecular Chaperones / Q000096:biosynthesis*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D015032:Zinc / Q000494:pharmacology
D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D005973:Glutamine; D015032:Zinc; D001241:Aspirin