CSF prostaglandin D synthase is reduced in excessive daytime sleepiness.
Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D(2), a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness.
Bassetti
Claudio L
CL
Department of Neurology, Universitätsspital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland. claudio.bassetti@usz.ch
Hersberger
Martin
M
Baumann
Christian R
CR
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002385:Cataplexy / Q000134:cerebrospinal fluid; D002908:Chronic Disease; D005260:Female; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000134:cerebrospinal fluid*; D054834:Lipocalins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000097:blood / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D017286:Polysomnography; D012892:Sleep Deprivation / Q000134:cerebrospinal fluid*; D012894:Sleep Stages
D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase