title: Sarcoma of the larynx: treatment results and literature review.
abstract: BACKGROUND
  Sarcomas of the larynx are rare neoplasms that constitute less than 1% of laryngeal malignancies. A Medline search found no large series focusing on laryngeal sarcomas. We reviewed the cases of laryngeal sarcomas treated in our cancer center and compared our experiences and treatment results with those from other centers.
  
  
  METHODS
  A retrospective review of 10 patients with laryngeal sarcoma treated in our institute between 1980 and 2000 was done to identify tumor characteristics, therapeutic modalities, and treatment outcomes.
  
  
  RESULTS
  The patients showed a male predominance (9/10) and presented 8 types of pathology. Nine patients underwent surgery, including 2 total laryngectomy, 4 partial laryngectomy, and 3 endoscopic laser cordectomy. During a median follow-up of 92 months, the 5-year overall survival and disease-specific survival were 76% and 90%, respectively. Two patients developed recurrence, including 1 local recurrence and 1 distant metastasis.
  
  
  CONCLUSIONS
  Surgical intervention was the first choice in the treatment of laryngeal sarcomas. The prognosis is relatively good when compared with sarcoma originating from other anatomic sites.
authors.affiliation: Department of Otolaryngology, Taipei Veterans General Hospital, and National Tang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Chia-Yu
authors.initials: CY
authors.lastname: Liu
authors.forename: Mao-Che
authors.initials: MC
authors.lastname: Wang
authors.forename: Wing-Yin
authors.initials: WY
authors.lastname: Li
authors.forename: Shyue-Yi
authors.initials: SY
authors.lastname: Chang
authors.forename: Pen-Yuan
authors.initials: PY
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D015996:Survival Rate