Synthesis of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid N-alkyl amides and their antioxidant activity.
A series of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid N-alkyl amides (3a-g) were synthesized and their antioxidant activities were evaluated using rat brain homogenates.
Cho
Jungsook
J
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Kang
Hae-Eun
HE
Jung
Jae-Kyung
JK
Lee
Heesoon
H
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002839:Chromans / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D015227:Lipid Peroxidation; D051381:Rats; D013329:Structure-Activity Relationship
D000577:Amides; D001578:Benzopyrans; D002839:Chromans; D016166:Free Radical Scavengers; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid