Engineered bio-nanocapsules, the selective vector for drug delivery system.
The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.
Yu
Dongwei
D
Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Okayama 700-8530, Japan.
Fukuda
Takayuki
T
Tuoya
Kuroda
Shun'ichi
S
Tanizawa
Katsuyuki
K
Kondo
Akihiko
A
Ueda
Masakazu
M
Yamada
Tadanori
T
Tada
Hiroko
H
Seno
Masaharu
M
D001698:Biomedical Engineering; D002214:Capsules / Q000737:chemistry*; D004337:Drug Carriers; D049329:Nanostructures / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000235:genetics
D002214:Capsules; D004337:Drug Carriers; C096362:L protein, hepatitis B virus; D014759:Viral Envelope Proteins