Solubility prediction of paracetamol in binary and ternary solvent mixtures using Jouyban-Acree model.
The Jouyban-Acree model has been used to predict the solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures based on model constants computed using a minimum number of solubility data of the solute in water-ethanol, water-propylene glycol and ethanol-propylene glycol binary mixtures. Three data points from each binary solvent system and solubilities in neat solvents were used to calculate the binary interaction parameters of the model. Then the solubility at other binary solvent compositions as well as in a number of ternary solvents were predicted, and the mean percentage deviation (+/-S.D.) of predicted values from experimental solubilities was 7.4(+/-6.1)%.
Jouyban
Abolghasem
A
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Iran. ajouyban@hotmail.com
Chan
Hak-Kim
HK
Chew
Nora Yat Knork
NY
Khoubnasabjafari
Maryam
M
Acree
William Eugene
WE
D000082:Acetaminophen / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D008956:Models, Chemical; D015233:Models, Statistical; D011237:Predictive Value of Tests; D019946:Propylene Glycol / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D012997:Solvents; D014867:Water; D000082:Acetaminophen; D000431:Ethanol; D019946:Propylene Glycol