ESAT-6 peptide recognition by bovine CD8+ lymphocytes of naturally infected cows in herds from southern Italy.
The aim of this study was to define epitopes of Mycobacterium bovis from ESAT-6 (early secretory antigen of 6 kDa) recognized by CD8+ T lymphocytes from cows naturally infected with Mycobacterium bovis. We found that bovine CD8+ T cells recognized 10 out of 11 ESAT-6 peptides tested.
Vitale
Fabrizio
F
Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi 3, 90100 Palermo, Italia.
Reale
Stefano
S
Petrotta
Enrico
E
Caracappa
Santo
S
Barera
Annalisa
A
La Manna
Marco Pio
MP
Macaluso
Pasquale
P
Caccamo
Nadia
N
Dieli
Francesco
F
Vordermeier
Hans Martin
HM
Sireci
Guido
G
Salerno
Alfredo
A
D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D001426:Bacterial Proteins; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D002417:Cattle; D002478:Cells, Cultured; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D009163:Mycobacterium bovis / Q000276:immunology*; D012802:Sicily; D014380:Tuberculosis, Bovine / Q000276:immunology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D018984:Epitopes, T-Lymphocyte; D007371:Interferon-gamma