title: Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy.
abstract: We followed up seven patients with histologically confirmed diffuse pigmented villonodular synovitis in a prospective study between 1992 ans 2001. The mean age at diagnosis was 30.7 years. The patients underwent synovectomy, followed by radiotherapy with a total dose of 35 Gy in 20 fractions. In all cases, the excision was considered incomplete when examined histologically. At an average follow up of 24 (18-36) months, six patients reported better function and reduced levels of pain. One patient remained symptomatic but did not have a recurrence. We conclude that a combined approach to a primary pigmented villonodular synovitis of the foot and ankle may reduce the risk of recurrence without functional impairment.
authors.affiliation: Bone and Soft Tissue Tumour Unit, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, London, UK. marcus.lee1@btinternet.com
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Mahroof
authors.forename: J
authors.initials: J
authors.lastname: Pringle
authors.forename: S C
authors.initials: SC
authors.lastname: Short
authors.forename: T W R
authors.initials: TW
authors.lastname: Briggs
authors.forename: S R
authors.initials: SR
authors.lastname: Cannon
mesh_terms: D000328:Adult; D000842:Ankle; D003131:Combined Modality Therapy; D005260:Female; D005528:Foot; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013586:Synovitis, Pigmented Villonodular / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome