title: Worsening of asthma with systemic corticosteroids. A case report and review of literature.
abstract: Despite widespread use for treatment of asthma and allergies, glucocorticoids may cause allergic reactions, even anaphylaxis. The incidence of adverse reactions to systemic glucocorticoids is 0.3%. The most commonly reported corticosteroids causing anaphylaxis like reactions are hydrocortisone, prednisone, and methylprednisolone. Most authors agree that allergic reactions to systemic corticosteroids are possibly immunoglobulin E mediated. We report a patient with asthma, aspirin allergy, and nasal polyps who developed bronchospasm following the administration of intravenous methylprednisolone sodium succinate during an acute asthmatic attack. We discuss the differential diagnosis of worsening asthma despite adequate treatment, and suggest corticosteroid-induced bronchospasm in our patient. Corticosteroid-induced bronchospasm should be considered when asthmatics fail to improve, or frankly deteriorate with systemic corticosteroid therapy, particularly when a history of aspirin allergy is present. TEACHING POINT: Know the differential diagnosis for worsening of asthma despite adequate treatment. Consider corticosteroid-induced bronchospasm when asthmatics fail to improve, or frankly deteriorate with systemic corticosteroid therapy. Corticosteroid-induced bronchospasm is more commonly seen in asthmatics with a history of aspirin allergy.
authors.affiliation: Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA. drankursheth@yahoo.com
authors.forename: Ankur
authors.initials: A
authors.lastname: Sheth
authors.forename: Savio
authors.initials: S
authors.lastname: Reddymasu
authors.forename: Robert
authors.initials: R
authors.lastname: Jackson
mesh_terms: D001241:Aspirin / Q000276:immunology; D001249:Asthma / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000150:complications; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications
chemical_list: D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate; D001241:Aspirin