[Clinical study on effect of fluoxetine combined with Chinese medicine or tibetan drugs in treating senile depression in plateau district].
OBJECTIVE
To compare the ettect and side-ettect of fluoxetine and combination of fluoxetine and Chinese or Tibetan medicine in treating senile depression in plateau district. Methods Ninety patients with diagnosis of senile depression conformed to CCMD-3 standard, in plateau district of 2260 - 3200 m altitude were randomly divided into three groups and treated with fluoxetine (group A), fluoxetine plus Sanpu Xinnao Xin granule (group B) and fluoxetine plus Xiaoyao pill (group C), respectively, 30 cases in each group. Therapeutic effects were evaluated with Hamilton' s depressive scale (HAMD) and treatment emergent symptom scale (TESS) after 6 weeks treatment.


RESULTS
There was no significant difference in the therapeutic effects between the three groups. The adverse reaction in Group B and C was less than that in Group A (P<0.01). Conclusion Sanpu Xinnao Xin granule and Xiaoyao pill can raise the tolerance of patients with senile depression in plateau area against the adverse reaction of fluoxetine.
Zhang
Hong-Wu
HW
The Affiliated Hospital of Qinghai University, Xining. qyfyxhn@163.com
Wang
Chun-Ying
CY
Xu
Hui-Ning
HN
Zhao
Xiuli
X
Dai
Qingxiang
Q
Li
Jun
J
Du
Xinbai
X
Song
Zhiqiang
Z
Han
Guoling
G
Liu
Guilan
G
Li
Pingshan
P
Lin
Huahua
H
D000368:Aged; D000531:Altitude; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D018687:Antidepressive Agents, Second-Generation; D004365:Drugs, Chinese Herbal; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors