Anti-neutrophil cytoplasm-associated glomerulonephritis.
Wegener's granulomatosis, microscopic polyangiitis, and renal limited vasculitis are associated with circulating anti-neutrophil cytoplasm antibodies and are an important cause of rapidly progressive glomerulonephritis. This review gives an account of recent advances in the understanding of the pathogenesis underlying these conditions and how these may lead to future treatments. Consideration is given to recent clinical trials in the management of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides.
Morgan
Matthew David
MD
Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Birmingham, United Kingdom.
Harper
Lorraine
L
Williams
Julie
J
Savage
Caroline
C
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology*; D003594:Cytoplasmic Granules / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D014657:Vasculitis / Q000276:immunology* / Q000473:pathology*
D019268:Antibodies, Antineutrophil Cytoplasmic