title: Intracerebral hematoma as a complication of intrathecal methotrexate administration.
abstract: Neurotoxicity of methotrexate is a well-documented issue, but development of an intracerebral hematoma following administration of intrathecal methotrexate is an extremely rare entity. A 6-year-old male with the diagnosis of non-Hodgkin lymphoma was put on a treatment regimen, including intrathecal methotrexate. Six days following the last intrathecal methotrexate administration, the patient developed a deteriorating state of consciousness. There was no history of trauma. Coagulation studies and platelet count were normal. Magnetic resonance imaging of the brain demonstrated a large left frontoparietal hematoma. Intracerebral hematoma may be a very rare, but serious, complication of intrathecal methotrexate administration.
authors.affiliation: Dr. Lutfi Kirdar Kartal Research and Training Hospital, 2nd Clinic of Pediatrics, Istanbul, Turkey. burakoboran@hotmail.com
authors.forename: Perran
authors.initials: P
authors.lastname: Boran
authors.forename: Gulnur
authors.initials: G
authors.lastname: Tokuc
authors.forename: Burak O
authors.initials: BO
authors.lastname: Boran
authors.forename: Sedat
authors.initials: S
authors.lastname: Oktem
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D002648:Child; D006406:Hematoma / Q000139:chemically induced*; D006801:Humans; D007278:Injections, Spinal; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D013129:Spinal Puncture
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate