title: [Is the metabolic syndrome a new childhood disease?].
abstract: Overweight and obesity in children and adolescents have become a major public health problem in recent years throughout the world. The medical consequences of obesity may manifest as an increase in the prevalence of the metabolic syndrome in children and adolescents putting them at increased risk for future cardiovascular diseases. Obesity can cause insulin resistance and might disturb glucose homeostasis eventually leading to type 2 diabetes in susceptible patients. Insulin resistance is also involved in the pathogenesis of dyslipidemia in obese children characteristically presenting as hypertriglyceridemia and low HDL cholesterol. Even elevated blood pressure might be present in obese kids. Here we present a 12-year-old boy diagnosed with the metabolic syndrome. The diagnostic criteria of the metabolic syndrome in children and adolescents are discussed. Thoughts about pathophysiology and therapeutic options are offered.
authors.affiliation: Pädiatrische Endokrinologie und Diabetologie, Medizinische Universitätskinderklinik Bern.
authors.forename: M
authors.initials: M
authors.lastname: Janner
authors.forename: P E
authors.initials: PE
authors.lastname: Mullis
authors.forename: C E
authors.initials: CE
authors.lastname: Flück
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000465:Algorithms; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D050171:Dyslipidemias / Q000175:diagnosis; D015444:Exercise; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D007223:Infant; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009765:Obesity / Q000175:diagnosis; D011379:Prognosis; D012307:Risk Factors