title: HBV genotypes and antiviral-resistant variants in HBV infected subjects in Northern Italy.
abstract: HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects.
authors.affiliation: Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy. mariacristina.medici@unipr.it
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Medici
authors.forename: Annalisa
authors.initials: A
authors.lastname: Aloisi
authors.forename: Monica
authors.initials: M
authors.lastname: Martinelli
authors.forename: Laura Anna
authors.initials: LA
authors.lastname: Abelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Casula
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Valcavi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Dettori
authors.forename: Carlo
authors.initials: C
authors.lastname: Chezzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy* / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D007558:Italy; D019259:Lamivudine / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral; D019259:Lamivudine