An online database for brain disease research.
BACKGROUND
The Stanley Medical Research Institute online genomics database (SMRIDB) is a comprehensive web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depression). This database contains fully annotated clinical metadata and gene expression patterns generated within 12 controlled studies across 6 different microarray platforms.


METHODS
A thorough collection of gene expression summaries are provided, inclusive of patient demographics, disease subclasses, regulated biological pathways, and functional classifications.


CONCLUSIONS
The combination of database content, structure, and query speed offers researchers an efficient tool for data mining of brain disease complete with information such as: cross-platform comparisons, biomarkers elucidation for target discovery, and lifestyle/demographic associations to brain diseases.
Higgs
Brandon W
BW
Elashoff Consulting LLC, Germantown, MD 20876, USA. brandon@elashoffconsulting.com
Elashoff
Michael
M
Richman
Sam
S
Barci
Beata
B
D001714:Bipolar Disorder / Q000235:genetics; D001927:Brain Diseases / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D030541:Databases, Genetic; D003866:Depressive Disorder / Q000235:genetics; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis; D012559:Schizophrenia / Q000235:genetics