title: Surgical menopause increases salt sensitivity of blood pressure.
abstract: Salt sensitivity of blood pressure is associated with an elevated risk of developing hypertension (HTN) and is an independent risk factor for cardiovascular disease. The prevalence of HTN increases after menopause. The aim of this study was to investigate prospectively whether the loss of ovarian hormones increases the occurrence of salt sensitivity among healthy premenopausal women. We enrolled 40 normotensive, nondiabetic women (age 47.2+/-3.5), undergoing hysterectomy-oophorectomy for nonneoplastic processes and not on hormone replacement, to determine the effect of changes in sodium intake on blood pressure the day before and subsequently 4 months after surgical menopause. Salt loading was achieved using a 2-L normal saline infusion and salt depletion produced by 40 mg of intravenous furosemide. A decrease >10 mm Hg in systolic blood pressure between salt loading and salt depletion was used to define salt sensitivity. Before and after menopause, salt-sensitive women exhibited higher waist/hip and waist/thigh ratios (P<0.01). Although all of the women remained normotensive, the prevalence of salt sensitivity was significantly higher after surgical menopause (21 women; 52.5%) than before (9 women; 22.5%; P=0.01), because 12 (38.7%) salt-resistant women developed salt sensitivity after menopause. In summary, we demonstrated that the prevalence of salt sensitivity doubled as early as 4 months after surgical menopause, without an associated increase in blood pressure. Epidemiological studies indicate that development of HTN may not occur until 5 to 10 years after menopause. The loss of ovarian hormones may unmask a population of women prone to salt sensitivity who, with aging, would be at higher risk for the subsequent development of HTN and cardiovascular disease.
authors.affiliation: Veterans Affairs Medical Center, Division of Nephrology, Hypertension and Vascular Biology Institute, University of Miami Miller School of Medicine, FL, USA.
authors.forename: Ivonne Hernandez
authors.initials: IH
authors.lastname: Schulman
authors.forename: Pedro
authors.initials: P
authors.lastname: Aranda
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Raij
authors.forename: Maddalena
authors.initials: M
authors.lastname: Veronesi
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Aranda
authors.forename: Remedios
authors.initials: R
authors.lastname: Martin
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008593:Menopause; D008875:Middle Aged; D010052:Ovariectomy; D011184:Postoperative Period; D011446:Prospective Studies; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012965:Sodium Chloride