title: Photoadaptation during narrowband ultraviolet-B therapy is independent of skin type: a study of 352 patients.
abstract: Understanding how photoadaptation differs between individuals is important when considering susceptibility to the beneficial and harmful effects of sunlight exposure and when determining optimal phototherapy regimens. Most narrowband UVB (NB-UVB) regimens start with 70% of the minimal erythema dose (MED) with 20% increments at each treatment thereafter. We retrospectively studied 352 skin types I-IV psoriatic patients having twice weekly treatment with this regimen. Patients with high skin types tended to have high MEDs (P<0.001). By session 20 the proportion of patients who had developed erythema was approximately 60% regardless of MED. Among patients who developed erythema, the number of treatments before erythema occurred did not differ between skin types (P=0.33). We conclude that patients with high skin types photoadapt approximately equally per physical unit of UVR in comparison to those with low skin types, but they have greater photoadaptation in absolute terms because they are able to tolerate a higher initial dose of radiation. Differences in skin type or MED are not associated with clinically important differences in tendency to erythema during a standard 70/20% NB-UVB twice-weekly regimen. This regimen is suitable for all skin types I-IV patients regardless of skin type or MED.
authors.affiliation: Photobiology Unit, St John's Institute of Dermatology, GKT School of Medicine, King's College, London, UK. roypalmer@totalise.co.uk
authors.forename: Roy A
authors.initials: RA
authors.lastname: Palmer
authors.forename: Susan
authors.initials: S
authors.lastname: Aquilina
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Milligan
authors.forename: Susan L
authors.initials: SL
authors.lastname: Walker
authors.forename: John L M
authors.initials: JL
authors.lastname: Hawk
authors.forename: Antony R
authors.initials: AR
authors.lastname: Young
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000368:Aged; D004307:Dose-Response Relationship, Radiation; D004890:Erythema; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000532:radiotherapy*; D012867:Skin / Q000473:pathology* / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000592:standards*