Fast capillary GC using a low thermal mass column oven for the determination of residual solvents in pharmaceuticals.
A low thermal mass column oven was used for fast capillary GC analysis (high throughput) of residual solvents in pharmaceutical products. A dedicated capillary column, 20 m L x 180 microm ID x 1 microm DB-624 was programmed from 35 degrees C (30 s) to 150 degrees C at 100 degrees C/min and to 250 degrees C (30 s) at 200 degrees C/min, resulting in a total GC cycle time of less than 4 min. Complete separation of a target 20-component mixture was achieved, while method performance in terms of repeatability, sensitivity, and linearity was maintained in comparison to the generic method currently applied in our laboratories.
David
Frank
F
Pfizer Analytical Research Centre, Ghent University, Krijgslaan, Ghent, Belgium.
Szücs
Roman
R
Makwana
Jay
J
Sandra
Pat
P
D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods; D006358:Hot Temperature; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000032:analysis*
D004364:Pharmaceutical Preparations; D012997:Solvents