Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix.
[structure: see text] The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6-disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an alpha-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
Kim
In Chul
IC
Department of Chemistry, Yale University, P.O. Box 20810, New Haven, Connecticut 06511, USA.
Hamilton
Andrew D
AD
D001555:Benzene Derivatives / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D017433:Protein Structure, Secondary; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry*
D001555:Benzene Derivatives; D007189:Indans; D011506:Proteins