title: Antimutagenic activity of Sesbania javanica Miq. flower DMSO extract and its major flavonoid glycoside.
abstract: The antimutagenic activity of Sesbania javanica Miq. or Sano, an edible vegetable flower DMSO extract against aflatoxin B1 (AFB1) benzo (a) pyrene [B(a)P], was evaluated by means of the Ames' test. The Sesbania javanica Miq. flower DMSO extract showed a strong inhibitory effect against AFB1 and B(a)P mutagens. A search to isolate the major flavonoid in Sesbania javanica Miq. flower extract found the flavonol glycoside, Quercetin 3-2(G)-rhamnosylrutinoside, which was confirmed by its physicochemical properties as a major constituent of the flower. Quercetin 3-2(G)-rhamnosylrutinoside (207 microg/plate) also showeda strong inhibitory effect against AFB1 and B(a)P with a more than 70% inhibition rate.
authors.affiliation: Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. surapon14t@yahoo.com
authors.forename: Surapon
authors.initials: S
authors.lastname: Tangvarasittichai
authors.forename: Nimit
authors.initials: N
authors.lastname: Sriprang
authors.forename: Talabporn
authors.initials: T
authors.lastname: Harnroongroj
authors.forename: Supranee
authors.initials: S
authors.lastname: Changbumrung
mesh_terms: D016604:Aflatoxin B1; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D005419:Flavonoids / Q000494:pharmacology*; D035264:Flowers; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D049931:Sesbania
chemical_list: D016587:Antimutagenic Agents; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; D016604:Aflatoxin B1; D004121:Dimethyl Sulfoxide