title: Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreas.
abstract: OBJECTIVE
  To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT.
  
  
  METHODS
  We analyzed the expression of p53 protein, proliferating cell nuclear antigen, alpha6-integrin subunit, alpha5beta1-integrin, and interleukin-1 receptor type I in tumor specimens from eight patients with MCT.
  
  
  RESULTS
  The tumors were classified as mucinous cyst adenoma (n=6) or mucinous cyst adenocarcinoma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha6-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha6-integrin subunit and p53 protein were also co-expressed.
  
  
  CONCLUSIONS
  Our present results indicate that coexpression of the alpha6-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.
authors.affiliation: Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan. cb8h-swi@asahi-net.or.jp
authors.forename: Hirozumi
authors.initials: H
authors.lastname: Sawai
authors.forename: Yiuji
authors.initials: Y
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Funahashi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Moritsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takeyama
authors.forename: Tadao
authors.initials: T
authors.lastname: Manabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018282:Cystadenocarcinoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D039503:Integrin alpha6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D053573:Receptors, Interleukin-1 Type I; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D039081:Integrin alpha5beta1; D039503:Integrin alpha6; D018809:Proliferating Cell Nuclear Antigen; D017472:Receptors, Interleukin-1; D053573:Receptors, Interleukin-1 Type I; D016159:Tumor Suppressor Protein p53