An integrated system for genetic analysis.
BACKGROUND
Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use.


METHODS
We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward.


CONCLUSIONS
IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.
Fiddy
Simon
S
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. simon.fiddy@well.ox.ac.uk
Cattermole
David
D
Xie
Dong
D
Duan
Xiao Yuan
XY
Mott
Richard
R
D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D004247:DNA / Q000235:genetics*; D003628:Database Management Systems; D020407:Internet; D015810:Linkage Disequilibrium / Q000235:genetics*; D010375:Pedigree; D016415:Sequence Alignment / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*; D018511:Systems Integration; D014584:User-Computer Interface
D004247:DNA