Thyrotropin-releasing hormone increased heat production without the involvement of corticotropin-releasing factor in neonatal chicks.
Thyrotropin-releasing hormone (TRH) is a hypothalamic signal in the hypothalamic-pituitary-thyroid (HPT) axis, and is well known as a hyperthermic hormone in the brain of chicks. The thermogenetic effect leads to the hypothesis that central TRH increases heat production (HP) in chicks. The purpose of the present study was to clarify whether central TRH affects HP of neonatal chicks, and if such an effect is mediated by corticotropin-releasing factor (CRF) since the thermogenetic effect of TRH is mediated by CRF. Intracerebroventricular (ICV) injection of TRH (14 and 55 nmol) dose-dependently increased oxygen consumption, carbon dioxide production and HP, and a similar effect was also observed with CRF (2.1 and 21 pmol). The TRH-induced increase in HP could not be attenuated by astressin, a CRF receptor antagonist, while the effect of CRF was completely diminished by astressin. The present study demonstrates that central TRH increases HP in chicks but the effect was not related to CRF.
Tachibana
Tetsuya
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Takahashi
Hirokazu
H
Oikawa
Daichi
D
Denbow
D Michael
DM
Furuse
Mitsuhiro
M
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002645:Chickens; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D022722:Thermogenesis / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D002245:Carbon Dioxide; D013973:Thyrotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone