New potential inhibitors of cyclin-dependent kinase 4: design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation.
A simple and efficient synthesis of 2-amino pyrido[2,3-d]pyrimidine derivatives was accomplished via a three-component reaction under microwave irradiation without catalyst. This method had many dramatic advantages such as the short reaction time, high yield, and broad substrate scope, as well as convenient operation. We provide new series of potential biologically active compounds as inhibitors of Cdk4.
Tu
Shujiang
S
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Xuzhou, Jiangsu 221009, PR China. laotu2001@263.net
Zhang
Jinpeng
J
Zhu
Xiaotong
X
Xu
Jianing
J
Zhang
Yan
Y
Wang
Qian
Q
Jia
Runhong
R
Jiang
Bo
B
Zhang
Junyong
J
D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D008872:Microwaves; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D011725:Pyridines; D011743:Pyrimidines; D051358:Cyclin-Dependent Kinase 4