title: Engineered bio-nanocapsules, the selective vector for drug delivery system.
abstract: The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Dongwei
authors.initials: D
authors.lastname: Yu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fukuda
authors.lastname: Tuoya
authors.forename: Shun'ichi
authors.initials: S
authors.lastname: Kuroda
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tanizawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kondo
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ueda
authors.forename: Tadanori
authors.initials: T
authors.lastname: Yamada
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tada
authors.forename: Masaharu
authors.initials: M
authors.lastname: Seno
mesh_terms: D001698:Biomedical Engineering; D002214:Capsules / Q000737:chemistry*; D004337:Drug Carriers; D049329:Nanostructures / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: D002214:Capsules; D004337:Drug Carriers; C096362:L protein, hepatitis B virus; D014759:Viral Envelope Proteins