title: Successful treatment of Candida parapsilosis mural endocarditis with combined caspofungin and voriconazole.
abstract: BACKGROUND
  Fungal mural endocarditis is a rare entity in which the antemortem diagnosis is seldom made. Seven cases of mural endocarditis caused by Candida spp. have been collected from literature and six of these patients died after treatment with amphotericin B.
  
  
  METHODS
  We report a case of mural endocarditis diagnosed by transesophageal echocardiogram and positive blood cultures to Candida parapsilosis. Because blood cultures continued to yield C. parapsilosis despite caspofungin monotherapy, treatment with voriconazole was added.
  
  
  CONCLUSIONS
  This is the first description of successful treatment of C. parapsilosis mural endocarditis with caspofungin and voriconazole.
authors.affiliation: Intensive Care Unit, Hospital Santa María Madre-Complejo Hospitalario de Ourense, Ourense, Spain. victor.jose.lopez.ciudad@sergas.es
authors.forename: Víctor
authors.initials: V
authors.lastname: López-Ciudad
authors.forename: María J
authors.initials: MJ
authors.lastname: Castro-Orjales
authors.forename: Cristóbal
authors.initials: C
authors.lastname: León
authors.forename: César
authors.initials: C
authors.lastname: Sanz-Rodríguez
authors.forename: María J
authors.initials: MJ
authors.lastname: de la Torre-Fernández
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Pérez de Juan-Romero
authors.forename: María D
authors.initials: MD
authors.lastname: Collell-Llach
authors.forename: María D
authors.initials: MD
authors.lastname: Díaz-López
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology*; D000077336:Caspofungin; D004359:Drug Therapy, Combination; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole