title: Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer.
abstract: CONCLUSIONS
  In patients with early glottic squamous cell carcinoma (SCC) submitted to CO2 laser endoscopic resection, local disease recurrence was significantly correlated with the presence of positive additional surgical margins on permanent sections.
  
  
  OBJECTIVE
  To evaluate the rate of cancer recurrence in patients with early glottic SCC submitted to CO2 laser endoscopic resection according to margin status after resection, stage of disease and postoperative radiotherapy. The rate of larynx preservation and the length of hospital stay were also evaluated.
  
  
  METHODS
  Forty consecutive patients with early glottic cancer were subjected to laser endoscopic resection surgery of glottic cancer followed by frozen-section control of margins, with intraoperative enlargement of margins when positive. Adjuvant radiation therapy or enlargement of previous margins was indicated in the case of positive additional surgical margins on permanent section.
  
  
  RESULTS
  Local recurrence occurred in three patients (7.5%), all with positive additional surgical margins on permanent section. Positive additional surgical margins on permanent section were related to 37.5% of recurrences and negative additional surgical margins with 0% of recurrences (p=0.006). All patients spent at most 1 day at the hospital.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Universidade Estadual de Campinas, São Paulo, Brazil.
authors.forename: Agricio N
authors.initials: AN
authors.lastname: Crespo
authors.forename: Carlos T
authors.initials: CT
authors.lastname: Chone
authors.forename: Flávio M
authors.initials: FM
authors.lastname: Gripp
authors.forename: Ana L
authors.initials: AL
authors.lastname: Spina
authors.forename: Albina
authors.initials: A
authors.lastname: Altemani
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005629:Frozen Sections; D005931:Glottis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007828:Laryngoscopy / Q000379:methods; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011336:Probability; D012086:Reoperation; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide