title: [Obesity in offspring with maternal undernutrition during pregnancy].
abstract: Recent epidemiology demonstrates higher rate of obesity and metabolic syndrome in offspring with undernutrition in utero. IUGR babies with intrauterine undernutrition grow rapidly to catch up with normal growth course. Leptin is an adipocyte derived satiety factor that regulates food intake and energy expenditure. We demonstrated in mice model with maternal food restriction during pregnancy that premature leptin surge during neonatal catch up growth of the offspring lead them to impaired leptin sensitivity and obesity in adulthood.
authors.affiliation: Kyoto University Graduate School of Medicine.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yura
authors.forename: Shingo
authors.initials: S
authors.lastname: Fujii
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004435:Eating / Q000235:genetics; D002149:Energy Intake / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D020738:Leptin / Q000502:physiology*; D044342:Malnutrition / Q000150:complications*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications
chemical_list: D020738:Leptin