Analysis of co-aggregation of cancer based on registry data.
OBJECTIVE
An exploratory analysis of co-aggregation of cancers using registry-based data.


METHODS
We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment.


RESULTS
We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01).


CONCLUSIONS
This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.
Matthews
Abigail G
AG
Massachusetts General Hospital Biostatistics Center, Boston, MA 02114, USA.
Betensky
Rebecca A
RA
Anton-Culver
Hoda
H
Bowen
Deborah
D
Griffin
Constance
C
Isaacs
Claudine
C
Kasten
Carol
C
Mineau
Geraldine
G
Nayfield
Susan
S
Schildkraut
Joellen
J
Strong
Louise
L
Weber
Barbara
B
Finkelstein
Dianne M
DM
D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D012042:Registries