title: The efficacy of an antiseptic and microbial anti-adhesive ear cleanser in dogs with otitis externa.
abstract: A new antimicrobial ear cleanser was evaluated for the treatment of bacterial and yeast ear infection in dogs. Forty-five dogs with erythemato-ceruminous or purulent otitis externa were randomly allocated to two treatment groups: reference ear cleanser (Epiotic, Virbac) or test ear cleanser (Epiotic Advanced, Virbac). Ear cleansing was performed twice daily for 2 weeks, and no other treatment was allowed. By week 2, clinical (exudate quantity, erythema, stenosis, excoriation, and odor) and discomfort (pain, ear scratching, and head shaking) scores were significantly decreased (P < .0001 for all) and no microbial overgrowth could be detected in 25 (64.1%) and 32 (68.1%) ears treated with Epiotic and Epiotic Advanced, respectively. The new pH-balanced, propylene glycol-free test ear cleanser, which incorporates microbial adhesin-blocking carbohydrates, proved as effective as the reference acidic formula.
authors.affiliation: Medical Department, Virbac Laboratories, 13eme rue LID, BP 27, F-06511 Carros, France.
authors.forename: C A
authors.initials: CA
authors.lastname: Rème
authors.forename: D
authors.initials: D
authors.lastname: Pin
authors.forename: C
authors.initials: C
authors.lastname: Collinot
authors.forename: M C
authors.initials: MC
authors.lastname: Cadiergues
authors.forename: J A
authors.initials: JA
authors.lastname: Joyce
authors.forename: J
authors.initials: J
authors.lastname: Fontaine
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001422:Bacterial Adhesion; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D004359:Drug Therapy, Combination; D004424:Ear Canal; D005260:Female; D008297:Male; D010032:Otitis Externa / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local