Substrate specificity of peptide adsorption: a model study.
Applying the contact density chain-growth algorithm to lattice heteropolymers, we identify the conformational transitions of a nongrafted hydrophobic-polar heteropolymer with 103 residues in the vicinity of a polar, a hydrophobic, and a uniformly attractive substrate. Introducing only two system parameters, the numbers of surface contacts and intrinsic hydrophobic contacts, respectively, we obtain surprisingly complex temperature and solvent dependent, substrate-specific pseudophase diagrams.
Bachmann
Michael
M
Institut für Theoretische Physik, Universität Leipzig, Augustusplatz 10/11, D-04109 Leipzig, Germany. Michael.Bachmann@itp.uni-leipzig.de
Janke
Wolfhard
W
D000327:Adsorption; D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D003198:Computer Simulation; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D012997:Solvents / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000596:Amino Acids; D010455:Peptides; D012997:Solvents