title: [Long term outcome following 26 surgical ampullectomies].
abstract: BACKGROUND
  Pancreaticoduodenectomy (PD) is the standard surgical treatment for malignant ampullomas but is still associated with a mortality and morbidity still ranging from 0 to 10% and from 15 to 40%, respectively. Ampullectomy is an alternative to PD for benign ampulloma or, in high-risk patients, for invasive carcinoma. The aim of this study was to report early and long term results of surgical ampullectomy for presumed benign ampullomas.
  
  
  METHODS
  From 1981 to 2004, 26 patients from two institutions underwent surgical ampullectomy. Of the 26 patients, 8 had familial adenomatous polyposis (FAP). Surgical ampullectomy was indicated on a multisciplinary basis.
  
  
  RESULTS
  Final pathological examination revealed 15 adenomas, 4 in situ adenocarcinomas, 2 endocrine tumors, and 5 other benign lesions. There was no postoperative mortality. Specific morbidity was 8% (N=2). Mean follow-up was 86+/-70 months (range: 3-204). Actuarial overall 5-year survival was 92%. There were 4 local recurrences (none in patients with FAP). Four patients died during follow-up (including 3 from initial disease).
  
  
  CONCLUSIONS
  Ampullectomy is a good alternative to PD in case of benign or non-invasive malignant ampullary lesion, including in selected cases of FAP.
authors.affiliation: Service de chirurgie digestive et générale, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite 13009 Marseille, France. ouaissi_mehdi@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Ouaïssi
authors.forename: I
authors.initials: I
authors.lastname: Sielezneff
authors.forename: A
authors.initials: A
authors.lastname: Alves
authors.forename: N
authors.initials: N
authors.lastname: Pirro
authors.forename: L
authors.initials: L
authors.lastname: Heyries
authors.forename: S
authors.initials: S
authors.lastname: Robitail
authors.forename: B
authors.initials: B
authors.lastname: Consentino
authors.forename: M-J
authors.initials: MJ
authors.lastname: Payan
authors.forename: P
authors.initials: P
authors.lastname: Valleur
authors.forename: Y
authors.initials: Y
authors.lastname: Panis
authors.forename: B
authors.initials: B
authors.lastname: Sastre
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000236:Adenoma / Q000601:surgery; D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery*; D002278:Carcinoma in Situ / Q000601:surgery; D002423:Cause of Death; D003137:Common Bile Duct Diseases / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000601:surgery; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012189:Retrospective Studies; D013005:Somatostatinoma / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome