title: Stabilizers and destabilizers controlling cell cycle oscillators.
abstract: Various destabilizing factors of the ubiquitin system contribute to the synchrony and unidirectionality of the cell cycle clock by finely tuning the activity of various CDKs. The recent findings of hierarchical and connected waves of cyclin stabilizers highlight the complexity of this network.
authors.affiliation: Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: Daniele
authors.initials: D
authors.lastname: Guardavaccaro
authors.forename: Michele
authors.initials: M
authors.lastname: Pagano
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*; D014452:Ubiquitins / Q000502:physiology*
chemical_list: D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes; D018844:Cyclin-Dependent Kinases