Novel and expeditious microwave-assisted three-component reactions for the synthesis of spiroimidazolin-4-ones.
Highly efficient methods for the syntheses of spiroimidazolinones via microwave-assisted three-component one-pot sequential reactions or one-pot domino reactions are described. The efficiency and utility of the methods have been demonstrated by quickly accessing the antihypertensive drug irbesartan (2).
Ye
Ping
P
ArQule, Incorporated, Division of Chemical Technologies, 19 Presidential Way, Woburn, Massachusetts 01801, USA.
Sargent
Katie
K
Stewart
Ethan
E
Liu
Ji-Feng
JF
Yohannes
Daniel
D
Yu
Libing
L