title: Treatment of a congenital pseudarthrosis of the tibia by osteogenic protein-1 (bone morphogenetic protein-7): a case report.
abstract: Congenital pseudarthrosis of the tibia remains one of the most difficult orthopaedic problems to treat. Before the use of a recombinant bone morphogenetic protein (bone morphogenetic protein-7; osteogenic protein-1) the patient with congenital pseudarthrosis of the tibia in this report had had 12 unsuccessful surgeries. Five months after radical resection of sclerotic tibial segments, Ilizarov fixation and administration of osteogenic protein-1 osteogenic device, the congenital pseudarthrosis of the tibia healed; at 45 months the tibia increased in size and the patient was fully weight bearing.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Darko
authors.initials: D
authors.lastname: Anticevic
authors.forename: Mislav
authors.initials: M
authors.lastname: Jelic
authors.forename: Slobodan
authors.initials: S
authors.lastname: Vukicevic
mesh_terms: D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D018889:Ilizarov Technique; D008297:Male; D019857:Osteogenesis, Distraction; D011542:Pseudarthrosis / Q000151:congenital / Q000473:pathology / Q000628:therapy*; D011859:Radiography; D011994:Recombinant Proteins; D013977:Tibia / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins