title: Prognostic value of HSP27 in head and neck squamous cell carcinoma: a retrospective analysis of 57 tumours.
abstract: BACKGROUND
  The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma (OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC.
  
  
  METHODS
  The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM, staging and survival rate. Univariate and multivariate analyses were performed.
  
  
  RESULTS
  HSP27 was found to be reduced in 31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by Cox regression).
  
  
  CONCLUSIONS
  HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive biological behaviour in OSCC cases even before relapse.
authors.affiliation: Department of Surgical Sciences, University of Foggia, Foggia, Italy. lomuziol@tin.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Campisi
authors.forename: Antonio
authors.initials: A
authors.lastname: Farina
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Francesca
authors.initials: F
authors.lastname: Ferrari
authors.forename: Silvia
authors.initials: S
authors.lastname: Falaschini
authors.forename: Rosalia
authors.initials: R
authors.lastname: Leonardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
authors.forename: Stefania
authors.initials: S
authors.lastname: Stalbano
authors.forename: Gaetano
authors.initials: G
authors.lastname: De Rosa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D006360:Heat-Shock Proteins