Common CYP450 drug interactions with psychiatric medicines: A brief review for the primary care physician.
With thousands of drug interactions possible, it is next to impossible to remember them all. Additionally, with the common use of psychiatric medicines in primary care practice, drug interactions may occur without recognition. Some drug interactions are negligible while other drug interactions are quite significant. It is most important to remember the drug interactions that can have a clinical effect. Since approximately half of all medications prescribed today are affected by P450 enzymes, it is important to recognize some important interactions. This brief review will address the most common medications used to treat psychiatric illnesses today and their potential to cause CYP450-mediated drug interactions.
Kutscher
Eric C
EC
Department of Clinical Pharmacy, South Dakota State University College of Pharmacy, USA.
Carnahan
Ryan
R
D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D001523:Mental Disorders / Q000188:drug therapy*; D011320:Primary Health Care
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D003577:Cytochrome P-450 Enzyme System