Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice.
Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide found throughout the brain, particularly in the nucleus accumbens (NAcc) and hypothalamus. CART was initially discovered and named based on the upregulation of its mRNA in the striatum after acute cocaine or amphetamine injection in rats. CART is also known to participate in a wider range of physiological functions including feeding, anxiety, bone resorption, and insulin regulation. In this report, we demonstrate that knockout mice lacking a functional CART gene show similar cocaine-induced locomotor sensitization and cocaine self-administration to their wild type siblings. Intravenous cocaine self-administration did not differ between CART wild type and knockout mice during acquisition, during schedules of reinforcement that require higher response ratios, or across a range of doses. In conclusion, these data indicate that CART is not integral to the effects of psychostimulants in mice lacking CART throughout development, although it may play a regulatory role in the intact animal.
Steiner
Rebecca C
RC
Interdepartmental Neuroscience Program and Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA.
Hsiung
Hansen M
HM
Picciotto
Marina R
MR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000494:pharmacology; D002755:Choice Behavior / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000235:genetics / Q000502:physiology*; D012054:Reinforcement, Psychology; D012646:Self Administration; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D000697:Central Nervous System Stimulants; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D003042:Cocaine