Solid-phase synthesis of oligo(p-benzamide) foldamers.
[reaction: see text] A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as well as N-hexyl protected monomers were investigated. Heterosequences of both monomers were synthesized. Such nanoscale objects are important building blocks for supramolecular chemistry.
König
Hannah M
HM
Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10-14, 55099 Mainz, Germany.
Abbel
Robert
R
Schollmeyer
Dieter
D
Kilbinger
Andreas F M
AF