I Siah substrate!
Proteins are targeted to the E3 RING ubiquitin ligase Siah through a PxAxVxP degron motif. In this issue of Structure, House et al. (2006) present the structural basis by which Siah recognizes its degron with high affinity and specificity.
Briant
Douglas J
DJ
Ceccarelli
Derek F
DF
Sicheri
Frank
F
D000818:Animals; D018360:Crystallography, X-Ray; D004331:Drosophila melanogaster; D009687:Nuclear Proteins / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry*; D000098563:Seven in Absentia Proteins
D009687:Nuclear Proteins; D044767:Ubiquitin-Protein Ligases; D000098563:Seven in Absentia Proteins