Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.
Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P(2)] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P(2). Coordinated synthesis of PtdIns(4,5)P(2) at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P(2) at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P(2) in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P(2) availability.
Ling
Kun
K
Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, Madison, WI 53706, USA.
Schill
Nicholas J
NJ
Wagoner
Matthew P
MP
Sun
Yue
Y
Anderson
Richard A
RA
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D022081:Cell Surface Extensions / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology; D008954:Models, Biological; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000096:biosynthesis / Q000502:physiology*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D014018:Tissue Distribution
D019269:Phosphatidylinositol 4,5-Diphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase