title: The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: a call for better disease recognition and evaluation of adjuncts to antifungal therapy.
abstract: We describe 9 nonimmunosuppressed patients with central nervous system cryptococcosis. Morbidity and mortality were high, especially among patients with cerebral infarcts. This was attributed to delayed diagnosis and apparent sequelae of overwhelming host immune responses. We present clues suggesting the diagnosis. Increased recognition and timely diagnosis of this condition may improve outcomes.
authors.affiliation: Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA.
authors.forename: Ismail Zafer
authors.initials: IZ
authors.lastname: Ecevit
authors.forename: Cornelius J
authors.initials: CJ
authors.lastname: Clancy
authors.forename: Ilona M
authors.initials: IM
authors.lastname: Schmalfuss
authors.forename: M Hong
authors.initials: MH
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000150:complications; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents