title: Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.
abstract: Visuospatial learning and memory impairments are an early marker for age-related cognitive decline and Alzheimer's disease. Similar to humans, aged dogs show visuospatial learning and memory deficits (). One hundred and nine beagle dogs ranging between 0.25 and 11.99 years were tested on a visuospatial delayed non-matching to position (DNMP) task to better characterize the progression of visuospatial deficits in the dog. Age predicted 48.2% of the variability in learning the DNMP, with dogs ranging from 1 to 11.99 years generally making more errors with increasing age. By contrast, puppies (<1 year) likely were showing developmental deficits, possibly due to an immature prefrontal cortex. Mild visuospatial deficits were detected by 6 years, which precedes the typical onset of amyloid-beta (Abeta) accumulation in the dog brain by two years, and can serve as an early marker for cognitive decline in the dog. These findings suggest that (1) age-related changes in visuospatial function in the dog models that seen in humans, further validating the dog as a model for human aging and dementia; and (2) other mechanisms, such as oxidative stress, soluble Abeta oligomers or cholinergic deficits, are likely contributing to the early impairment.
authors.affiliation: Department of Pharmacology, University of Toronto, 1265 Military Trail, Scarborough, Ont., Canada M1C 1A4. studzinski@utsc.utoronto.ca
authors.forename: Christa M
authors.initials: CM
authors.lastname: Studzinski
authors.forename: Lori-Ann
authors.initials: LA
authors.lastname: Christie
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Araujo
authors.forename: W McIntyre
authors.initials: WM
authors.lastname: Burnham
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Head
authors.forename: Carl W
authors.initials: CW
authors.lastname: Cotman
authors.forename: Norton W
authors.initials: NW
authors.lastname: Milgram
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D003704:Dementia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D004193:Discrimination Learning / Q000502:physiology*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D010775:Photic Stimulation; D013028:Space Perception / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
chemical_list: D015415:Biomarkers