title: Efficacy and safety of preoperative etodolac and butorphanol administration in dogs undergoing ovariohysterectomy.
abstract: Eighteen dogs undergoing ovariohysterectomy were premedicated with etodolac, butorphanol, or their combination. Various parameters, such as blood pressure, isoflurane requirements, behavioral pain scores, plasma cortisol concentration, plasma glucose concentration, and mucosal bleeding time, were assessed. The integrated plasma cortisol values were significantly lower in the etodolac and etodolac with butorphanol groups. Dogs receiving etodolac and butorphanol had the lowest behavioral pain scores from extubation until the end of monitoring. Isoflurane concentration over time (area under the curve), buccal mucosal bleeding time, and indices of renal function were not significantly different among the treatment groups.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Tomohito
authors.initials: T
authors.lastname: Inoue
authors.forename: Jeff C
authors.initials: JC
authors.lastname: Ko
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Mandsager
authors.forename: Mark E
authors.initials: ME
authors.lastname: Payton
authors.forename: David S
authors.initials: DS
authors.lastname: Galloway
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Lange
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002077:Butorphanol / Q000008:administration & dosage* / Q000009:adverse effects; D004285:Dogs / Q000097:blood / Q000502:physiology / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D017308:Etodolac / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D007044:Hysterectomy / Q000379:methods / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage; D010052:Ovariectomy / Q000379:methods / Q000662:veterinary; D010149:Postoperative Pain / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D019106:Postoperative Hemorrhage / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D012449:Safety; D016896:Treatment Outcome
chemical_list: D017308:Etodolac; D007530:Isoflurane; D002077:Butorphanol; D006854:Hydrocortisone