Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents.
[reaction: see text] A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO(2)Me) gave excellent yields (89%).
Ottesen
Lars K
LK
ACADIA Pharmaceuticals AB, Medeon Science Park S-20512, Malmö, Sweden.
Ek
Fredrik
F
Olsson
Roger
R
D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
D002712:Chlorides; D007202:Indicators and Reagents; D007501:Iron