The prevalence and risk factors of osteoporosis in Thai renal-transplant patients.
OBJECTIVE
To determine the prevalence and risk factors of osteoporosis after renal transplantation in Thai patients.


METHODS
A single-center cross-sectional study of bone mineral density was conducted in 102 Thai renal allograft recipients. Correlations were made between the clinical parameters and the occurrences of osteoporosis.


RESULTS
The prevalence of osteoporosis was 24.5%, 9.8% and 26.4% at lumbar vertebrae, hip region, and any sites, respectively. Binary logistic regression analysis revealed that cumulative dosage of steroids was significantly correlated with osteoporosis of the lumbar spine (p = 0.023, adjusted OR = 1.005), while body mass index (p = 0.005, adjusted OR = 0.738) and age (p = 0.052, adjusted OR = 1.077) were correlated with osteoporosis of the hip region.


CONCLUSIONS
Osteoporosis is common in Thai renal allograft recipients, particularly of the lumbar vertebrae. Cumulative dosage of steroids is the most important risk factor of low BMD of the lumbar vertebrae.
Techawathanawanna
North
N
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Avihingsanon
Yingyos
Y
Praditpornsilpa
Kerkiat
K
Kingpetch
Kannaungnit
K
Suwanwalaikorn
Sompong
S
Kanjanabuch
Talemgsak
T
Eiam-Ong
Somchai
S
Tungsanga
Kriang
K
D015519:Bone Density; D003430:Cross-Sectional Studies; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006615:Hip / Q000503:physiopathology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology
D016572:Cyclosporine