title: [Disseminated tuberculosis and profound thrombopenia].
abstract: Thrombocytopenia within the context of disseminated tuberculosis can lead to complications requiring rapid treatment. Although the origin is generally central, thrombocytopenia can arise from an immune disorder. We hereby report a case of disseminated tuberculosis associated with thrombocytopenia, which required, in addition to antituberculosis therapy initiated before bacteriological proof, corticosteroid treatment and multiple platelet transfusions. The discovery of anti-platelet antibodies along with the success of immunomodulator therapy confirmed the auto-immune origin of this thrombocytopenia.
authors.affiliation: Centre de Diagnostic, Hôtel-Dieu, AP-HP, 4 Place du Parvis Notre-Dame, 75181 Paris cedex 04.
authors.forename: P
authors.initials: P
authors.lastname: Leroux
authors.forename: H
authors.initials: H
authors.lastname: de Champs Léger
authors.forename: C-A
authors.initials: CA
authors.lastname: Le Vezouet
authors.forename: D
authors.initials: D
authors.lastname: Ilie
authors.forename: C
authors.initials: C
authors.lastname: Regnier
authors.forename: P
authors.initials: P
authors.lastname: Motlagh
authors.forename: J-H
authors.initials: JH
authors.lastname: Soulie
authors.forename: C
authors.initials: C
authors.lastname: Perles
authors.forename: J-C
authors.initials: JC
authors.lastname: Gilbert
authors.forename: M
authors.initials: M
authors.lastname: Safar
authors.forename: J
authors.initials: J
authors.lastname: Blacher
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013902:Radiography, Thoracic; D013921:Thrombocytopenia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D014376:Tuberculosis / Q000097:blood* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents