Angiotensin-converting enzyme gene insertion/deletion polymorphism in Korean patients with systemic sclerosis.
To determine whether angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is associated with the development and clinical features of systemic sclerosis (SSc) in Korean, we studied seventy two Korean patients with SSc fulfilling the ACR preliminary classification criteria. The controls were 114 healthy, disease free Koreans. ACE I/D genotypes were determined by PCR method using oligonucleotides. Sixty eight patients (94.4%) were women and age at diagnosis was 43.5+/-12.6 yr old (mean+/-SD). Thirty nine patients (54.2%) had a diffuse type of SSc. There were no statistical differences in the frequencies of all ACE I/D genotypes and D allele between patients and controls, and neither between diffuse and limited types of SSc. ACE I/D gene polymorphism was not associated with the development of SSc in Korea. The investigation for the pathogenesis of SSc requires more studies about the role of other candidate genes such as endothelin, TGF-beta, nitric oxide, or angiotensin II receptor in addition to the ACE genes.
Joung
Chung Il
CI
Division of Rheumatology, Department of Internal Medicine, Konyang University Hospital, Daejeon, Korea.
Park
Yong Wook
YW
Kim
Sook Kyoung
SK
Uhm
Wan Sik
WS
Kim
Tae Hwan
TH
Yoo
Dae Hyun
DH
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012595:Scleroderma, Systemic / Q000201:enzymology* / Q000235:genetics*
D004247:DNA; D007703:Peptidyl-Dipeptidase A