Evaluation of chemopreventive action of Ginsenoside Rp1.
We evaluated the chemopreventive properties of Ginsenoside Rp1 on 7,12-Dimethyl benz (a) anthracene (DMBA) skin papillomagenesis in Swiss albino mice. A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre-, peri- and post-initiational stages of papillomagenesis as compared to the control group. Chemopreventive potential of Ginsenoside Rp1 was also observed on the skin metabolizing enzymes in Swiss albino mice. Ginsenoside Rp1 produced a significant elevation in the skin microsomal cytochrome p-450 and cytochrome b5, glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR), DT-diaphorase, superoxide dismutase (SOD) and catalase levels in the group of mice treated with Ginsenoside Rp1 for seven consecutive days. However, there was significant decrease in lipid peroxidation (LPO) level in Ginsenoside Rp1 treated group.
Kumar
Ashok
A
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302004, India. mamsjpr@hotmail.com
Kumar
Madhu
M
Panwar
Meenakshi
M
Samarth
Ravindra M
RM
Park
Tae Yoon
TY
Park
Myung Hwan
MH
Kimura
Hiroshi
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D002374:Catalase / Q000032:analysis; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D015786:Cytochromes b5 / Q000032:analysis; D036145:Ginsenosides / Q000627:therapeutic use*; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000032:analysis; D010084:Oxidation-Reduction; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D011897:Random Allocation; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000737:chemistry / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000032:analysis
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D036145:Ginsenosides; C512675:ginsenoside Rp1; D015127:9,10-Dimethyl-1,2-benzanthracene; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone); D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione