title: Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
abstract: OBJECTIVE
  To investigate the effect of vitamin K2 (menatetrenone) treatment on bone mineral density (BMD) and a bone metabolic marker (osteocalcin) in postmenopausal women with osteoporosis living in Indonesia.
  
  
  METHODS
  A double-blind randomized placebo-controlled study of 63 postmenopausal women with osteoporosis. The vitamin K2 group (n = 33) received 45 mg menatetrenone and 1500 mg calcium carbonate per day and the control group (n = 30) received placebo and 1500 mg calcium carbonate per day for 48 weeks. BMD of lumbal spine (L2-L4), osteocalcin (OC) and undercarboxylated OC were measured before, 24 and 48 weeks after initiation of the treatment.
  
  
  RESULTS
  After 48 weeks of treatment, the mean percentage change of lumbar BMD in the vitamin K2 group was significantly higher (P < 0.05) than that of the control group. The undercarboxylated OC level decreased by 55.9% in the menatetrenone group and 9.3% in the control group compared with the baseline level. The difference between the two groups was significant (P < 0.01). The adverse events were three minor gastrointestinal cases, which subsided after temporary cessation of therapy.
  
  
  CONCLUSIONS
  Treatment with 45 mg vitamin K2 with 1500 mg calcium per day for postmenopausal women with osteoporosis for 48 weeks resulted in a significant increase in lumbar BMD and a significant decrease in undercarboxylated OC levels.
authors.affiliation: Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia. yudi@med.showa-u.ac.jp
authors.forename: Yuditiya
authors.initials: Y
authors.lastname: Purwosunu
authors.lastname: Muharram
authors.forename: Ichramsyah A
authors.initials: IA
authors.lastname: Rachman
authors.forename: Soelarto
authors.initials: S
authors.lastname: Reksoprodjo
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sekizawa
mesh_terms: D000368:Aged; D015519:Bone Density; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007214:Indonesia; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D010919:Placebos; D024482:Vitamin K 2 / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D015675:Osteocalcin; D024482:Vitamin K 2