Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease.
Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and is capable of providing additional functional information. This combination allows for comprehensive diagnostic evaluation of pathologies such as ischemic renal disease. Noninvasive MRI techniques could facilitate translation of many studies performed in controlled animal models using technologies that are invasive to humans. Such a translation is being recognized as essential because many proposed interventions and drugs that prove efficacious in animal models fail to do so in humans. In this article, we review the state-of-the-art functional MRI technique as applied to the kidneys.
Prasad
Pottumarthi V
PV
Dept. of Radiology, Walgreen Jr. Bldg., Suite 507, Evanston Northwestern Healthcare, 2650 Ridge Ave., Evanston, IL 60201, USA. pprasad@enh.org
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical