Correction of systematic errors in CORE processing of DOSY data.
DOSY data for mixtures are commonly processed either by single channel methods (e.g. HR-DOSY) or multichannel methods (e.g. CORE). Both aim to separate the signals from species of different molecular sizes by their diffusion coefficients; the result is displayed either as a 2D plot (as in HR-DOSY) or as individual spectra (as in CORE). Both types of methods are sensitive to any systematic errors in the experimental data. The effects of, and remedies for, two such sources of error, spatially non-uniform pulsed field gradients (PFGs) and instrument instability, are demonstrated for CORE processing, using a corrected form of the Stejskal-Tanner equation and reference deconvolution, respectively.
Nilsson
Mathias
M
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. mathias.nilsson@manchester.ac.uk
Morris
Gareth A
GA