title: [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period].
abstract: OBJECTIVE
  To investigate the protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period.
  
  
  METHODS
  Thirty-four patients with hypertension underwent general anesthesia were randomly divided into the control group and the puerarin group, 500mg puerarin was given to the puerarin group 1hr before anesthesia induction by venoclysis and to the control group, normal saline was given instead. The concentration of serum cardiac troponin I (cTnI) and isoenzyme of creatine kinase containing M and B subunits (CK-MB) were measured before anesthesia induction and 2 hrs after operation respectively.
  
  
  RESULTS
  The serum concentration of cTnI and CK-MB were insignificantly different in the two groups before induction, the two indexes increased in different degrees (P <0.01) 2 hrs after operation in both groups, but the increments in the puerarin group were significantly lower than those in the control group (P< 0.01).
  
  
  CONCLUSIONS
  Stress of operation and anesthesia could induce myocardial injury in patients with hypertension, which can be prevented by puerarin medicated during perioperational period.
authors.affiliation: Hospital of Integrated Traditional and Western Medicine of Foshan City, Guangdong 4 528333. Wupeer@163.com
authors.forename: Xian-Ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Jun-Guang
authors.initials: JG
authors.lastname: Feng
authors.forename: Hao-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.forename: Lipei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Wei
authors.forename: Weicai
authors.initials: W
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000601:surgery; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D019990:Perioperative Care; D008517:Phytotherapy; D019210:Troponin I / Q000097:blood
chemical_list: D007529:Isoflavones; D019210:Troponin I; D052279:Creatine Kinase, MB Form; C033607:puerarin