[Effect of excessive iodine exposure on the serum TC and TG level in rats].
OBJECTIVE
To study effect of excessive iodine exposure on the serum TC and TG level in rate.


METHODS
According to body weight, 60 Wistar rats were divided into 6 groups and given drinking water including different doses of iodine. The iodine concentrations were 0 (control), 1800, 3600, 7200, 14000 and 28000 microg/L, respectively. Three months later, related indices were determined.


RESULTS
In excessive iodine groups, no obvious changes of thyroid morphology was observed. Urinary iodine level increased dose-dependently. Excessive iodine intake resulted in a significant reduce of serum TT4 level and an obvious increase of serum TC level in a dose-dependent manner. The positive correlation was observed between serum TC and urinary iodine. There was the negative correlation between serum TC and serum T4.


CONCLUSIONS
Excessive-iodine exposure resulted in an increase in serum TC level. And serum lipids, together with urinary iodine and serum thyroid hormones, could be used as biomarkers for excessive iodine exposure.
Yang
Xue-Feng
XF
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Hua zhong University of Science and Technology, Wuhan 430030, China.
Pang
Hong
H
Xu
Jian
J
Guo
Huai-Lan
HL
Hou
Xiaohui
X
Chen
Xiaoyi
X
Sun
Xiufa
X
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood
D014280:Triglycerides; D014284:Triiodothyronine; D007455:Iodine; D002784:Cholesterol; D013974:Thyroxine