Intrarectal administration of lidocaine gel versus plain lubricant gel for pain control during transrectal ultrasound-guided extensive 10-core prostate biopsy in Hong Kong Chinese population: prospective double-blind randomised controlled trial.
OBJECTIVE
To compare the level of pain experienced by patients during transrectal ultrasound-guided prostatic biopsy using intrarectal 2% lidocaine gel versus plain lubricant gel.


METHODS
Prospective double-blind randomised controlled trial.


METHODS
Regional hospital, Hong Kong.


METHODS
From March 2002 to December 2003, patients who underwent ultrasound-guided prostate biopsy at a Geriatric Urology Centre.


METHODS
Pain and discomfort scores measured by horizontal visual analogue scales.


RESULTS
A total of 338 consecutive patients were randomised to lidocaine gel or plain lubricant gel groups. The two groups were statistically similar in demographic and disease characteristics. There were no significant statistical differences in pain or discomfort score in the lidocaine gel and plain lubricant groups--pain score: 1.75 versus 1.79 (P=0.66) on day 0 and 0.21 versus 0.15 (P=0.97) on day 1; discomfort score: 0.79 versus 0.77 (P=0.86) on day 0 and 0.12 versus 0.12 (P=0.76) on day 1. No major complications were recorded in this cohort.


CONCLUSIONS
Transrectal ultrasound-guided trucut biopsy of the prostate can be safely performed with no anaesthesia in Chinese patients. Pain and discomfort are minimal. It was found that 2% lidocaine gel has no statistical therapeutic or analgesic benefit over plain lubricant gel.
Leung
S Y L
SY
Geriatric Urology Centre, Department of Surgery, University of Hong Kong, Tung Wah Hospital, Sheung Wan, Hong Kong. leungsyl@hku.hk
Wong
B B W
BB
Cheung
M C
MC
Ho
K L
KL
Lee
F C W
FC
Tam
P C
PC
D000285:Administration, Rectal; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000627:therapeutic use*; D001707:Biopsy, Needle; D004311:Double-Blind Method; D005782:Gels; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018084:Ultrasonography, Interventional / Q000009:adverse effects*
D000779:Anesthetics, Local; D005782:Gels; D008012:Lidocaine