title: Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.
abstract: A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1beta,2alpha,3alpha,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1-2 and 4-8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 microM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: WenYi
authors.initials: W
authors.lastname: Jin
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: JongPill
authors.initials: J
authors.lastname: Lee
authors.forename: RackSeon
authors.initials: R
authors.lastname: Seong
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: KyungSik
authors.initials: K
authors.lastname: Song
authors.forename: YeonHee
authors.initials: Y
authors.lastname: Seong
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012756:Sheep; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D014315:Triterpenes; D003165:Complement System Proteins