title: Prior therapy with antiplatelet agents is not associated with outcome in patients with acute ischemic stroke/TIA.
abstract: OBJECTIVE
  It is unclear whether prior therapy with antiplatelet agents (APA) is associated with a better outcome in patients with acute ischemic cerebrovascular events.
  
  
  METHODS
  Within a multi-center cross-sectional study, nested in a cohort we analyzed the relation between prior therapy with APA and stroke severity in 1643 patients with acute ischemic stroke or TIA. Clinical severity of the vascular event was evaluated by the National Institutes of Health Stroke Scale on admission (NIHSS1) and after 1 week (NIHSS2). By means of analysis of variance we analyzed a possible association of APA with stroke severity and interactions regarding stroke severity between APA and other clinical measures.
  
  
  RESULTS
  475 patients (29 %) received aspirin prior to the cerebrovascular event, 51 patients (3 %) ticlopidine or clopidogrel and 26 patients (1.6%) aspirin combined with extended release dipyridamole. 66% (1091) of patients did not take any antiplatelet medication. Neither the NIHSS1 nor the NIHSS2 nor the change of stroke severity between these time points (NIHSS1- NIHSS2) was associated with prior APA medication. We did not find significant interactions between APA use and clinical measures regarding stroke severity.
  
  
  CONCLUSIONS
  Our results do not indicate that prior therapy with APA is associated with a better outcome in acute ischemic cerebrovascular events. There were no interactions found with other features that were associated with stroke severity.
authors.affiliation: Department of Neurology Medical, University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Greisenegger
authors.forename: S
authors.initials: S
authors.lastname: Tentschert
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Ferrari
authors.forename: W
authors.initials: W
authors.lastname: Lang
authors.forename: W
authors.initials: W
authors.lastname: Lalouschek
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012008:Recurrence; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D010975:Platelet Aggregation Inhibitors