Risperidone and adaptive behavior in children with autism.
OBJECTIVE
To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change.


METHODS
Forty-eight children (5 years to 16 years, 5 months) who showed behavioral improvement during acute treatment with risperidone were followed for 6 months and assessed with the Vineland Scales.


RESULTS
Raw scores, age-equivalents, and special norm percentile scores all showed significant increases in adaptive behavior in the areas of communication, daily living skills, and socialization (p <.01). During a period of 6 to 8 months, children gained an average of 7.8 age-equivalent months in the area of socialization, a > 6% improvement beyond what would be expected based on baseline growth rates.


CONCLUSIONS
Although limited by the absence of a control group, these results suggest that risperidone may improve adaptive skills in children with autistic disorder accompanied by serious behavioral problems. Vineland age-equivalent scores appear to be most useful in assessing change with treatment over time.
Williams
Susan K
SK
Yale University, New Haven, CT 06520-7900, USA.
Scahill
Lawrence
L
Vitiello
Benedetto
B
Aman
Michael G
MG
Arnold
L Eugene
LE
McDougle
Christopher J
CJ
McCracken
James T
JT
Tierney
Elaine
E
Ritz
Louise
L
Posey
David J
DJ
Swiezy
Naomi B
NB
Hollway
Jill
J
Cronin
Pegeen
P
Ghuman
Jaswinder
J
Wheeler
Courtney
C
Cicchetti
Domenic
D
Sparrow
Sara
S
D000203:Activities of Daily Living; D000223:Adaptation, Psychological / Q000187:drug effects*; D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003142:Communication; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D018967:Risperidone / Q000627:therapeutic use*; D012919:Social Behavior
D014150:Antipsychotic Agents; D018967:Risperidone