[Topical liquid nasal gel, its anatomical distribution and transport].
The objectives of this study are: 1) to assess the anatomical distribution of a topical liquid nasal gel in patients with and without rhinitis using a metered dose nasal pump, and 2) to determine whether the distribution pattern is influenced by dosage and delivery technique. Thirty-nine volunteers were evaluated, 26 without nasal inflammation and 13 with rhinitis. Patients self-administered the nasal spray according to the specifications in one fossa and incorrectly in the other one (sniffing and double doses). The findings showed that the nasal gel delivered by spray did not penetrate beyond the inferior part of the middle turbinate, regardless of delivery technique (double dose with sniffing or single dose without sniffing) and the presence or absence of inflammation.
Herranz González-Botas
J
J
Servicio de Otorrinolaringología, Hospital Universitario Juan Canalejo, A Coruña. jhg@canalejo.org
Galindo Campillo
N
N
Desanto
L W
LW
García Simal
M
M
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005782:Gels / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012220:Rhinitis / Q000188:drug therapy / Q000378:metabolism; D014018:Tissue Distribution
D005782:Gels