[Insulin in the treatment of ischemic stroke].
Hyperglycemia is correlated with poor prognosis in ischemic strokes and also increases the risk of hemorrhagic transformation after thrombolysis. The toxicity of hyperglycemia, already well established in animals, is beginning to be clear for humans. On the other hand, the beneficial effect of insulin remains controversial in animals and has never been demonstrated in humans. Preliminary data, which suggest that the speed and quality of glycemic control may be decisive in the efficacy of treatment, merit testing in a randomized trial.
Samson
Yves
Y
Urgences Cérébrovasculaires, Groupe Hospitalier Pitié-Salpêtrière et Université Pierre et Marie Curie-Paris VI, Paris. yves.samson@psl.aphp.fr
Bruandet
Marie
M
Lejeune
Marie
M
Deltour
Sandrine
S
Grimaldi
André
A
D001786:Blood Glucose / Q000032:analysis; D002544:Cerebral Infarction / Q000209:etiology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007333:Insulin Resistance; D015201:Meta-Analysis as Topic; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin