title: Reproducibility of volume measurements of vestibular schwannomas - a preliminary study.
abstract: OBJECTIVE
  A preliminary study to investigate the intra-observer and inter-observer variability of measurements of vestibular schwannoma volume using an area-tracing and linear dimension measurement method.
  
  
  METHODS
  Prospective blinded measurements by two observers (one a consultant and one a sub-specialty trainee in neuroradiology).
  
  
  METHODS
  Ambulatory patients with known vestibular schwannoma attending a tertiary referral centre.
  
  
  METHODS
  Twenty-three patients with 26 vestibular schwannomas aged 29-80 years old.
  
  
  METHODS
  Quantification of the variability in measured volume due to intra- and inter-observer measurement differences, expressed as reliability coefficients within which 95% of repeated measurements are calculated to lie from each other in relative percentage terms.
  
  
  RESULTS
  For the linear measurement method, intraobserver variability was calculated to have a reliability coefficient of 65% and for interobserver variability this was 155%. For the area tracing method, the corresponding coefficients were 26% for intraobserver variability and 44% for interobserver variability.
  
  
  CONCLUSIONS
  Volume measurements in vestibular schwannoma are variable even when the measurements are made by the same observer on identical images. The area tracing method, commonly regarded as the gold standard, is less variable than a linear method but still introduces more variability than commonly realized (for 95% of patients, repeated measurements by the same observer lie within around 25% of each other). Manual area tracing is not widely used in practice because it is time consuming and reliable automated methods are eagerly awaited.
authors.affiliation: Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cross
authors.forename: D M
authors.initials: DM
authors.lastname: Baguley
authors.forename: N M
authors.initials: NM
authors.lastname: Antoun
authors.forename: D A
authors.initials: DA
authors.lastname: Moffat
authors.forename: A T
authors.initials: AT
authors.lastname: Prevost
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology*; D015588:Observer Variation; D011446:Prospective Studies; D015203:Reproducibility of Results