title: Regional cerebral perfusion abnormalities in developmental language disorder. Statistical parametric mapping analysis.
abstract: OBJECTIVE
  A voxel based investigation of cerebral blood flow was conducted to identify brain functional differences during resting state between children with developmental language disorder (DLD) and normal controls.
  
  
  METHODS
  Using DSM-IV criteria, we selected 21 children with DLD. All children were examined by technetium-99m-HMPAO Brain SPECT. Using SPM analyses, we compared the SPECT images of children with DLD and those of 17 control subjects on a voxel by voxel basis using ANCOVA covarying for age.
  
  
  RESULTS
  Reduced cerebral blood flow in the right putamen,the right inferior parietal cortex, and the left globus pallidus were found in children with DLD versus the controls. However, no area of increased cerebral blood flow was observed in children with DLD compared to the controls.
  
  
  CONCLUSIONS
  Though results should be interpreted cautiously, this study confirms the presence of functional defects in the basal ganglia and the inferior parietal lobe during the resting state of the brains of children with DLD. It also gives further evidence for functional deficits in basal ganglia as an important factor in the etiology of DLD.
authors.affiliation: Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital, Chongnogu, Seoul, Korea.
authors.forename: Jun Won
authors.initials: JW
authors.lastname: Hwang
authors.forename: Jeong-Bum
authors.initials: JB
authors.lastname: Lee
authors.forename: Boong-Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
mesh_terms: D000367:Age Factors; D001921:Brain / Q000098:blood supply; D001931:Brain Mapping / Q000379:methods*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000000981:diagnostic imaging*; D008297:Male; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data
chemical_list: D019690:Technetium Tc 99m Exametazime