[The influence of intermediate physical training on some non-enzyme antioxidants of oxidative stress, in moderate hypertension].
A group of patients with moderate hypertension (149-150/90-99 mm Hg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some biochemical markers, non-enzyme antioxidants, glutathione (GSH), total -SH groups (G-STH), nonprotein -SH groups (G-SHNP), their G-SHT/G-SHNP ratio, uric acid, malondialdehyde (MDA) and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the HTA patients, with initial (Vi) decreasing values of GSH and uric acid, and with higher values of MDA. After the 3 months (Vf) of physical training, the oxidative stress improved, with increasing GSH, uric acid and decreasing MDA, compared to normal subjects. The initial values of G-SHT, G-SHNP and their ratio, increased, but decreased after 3 months, with an inverse aspect to GSH. The clinical study proved that after 3 months of physical exercise, there wasn't any increased oxidative stress at the HTA patients; however, the oxidative stress is present, proved by the values of MDA, significantly higher compared to the normal subjects.
Jerca
Luminiţa
L
Universitatea de Medicină şi Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Disciplina de Biochimie.
Chiriac
Silvia
S
Jerca
Oltiţa Putină
OP
Cozma
Corina Dima
CD
Constantinescu
Irina
I
Chiriac
St
S
Gheorghiţă
Nastasia
N
Pandele
G I
GI
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015444:Exercise; D005978:Glutathione / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D014527:Uric Acid; D008315:Malondialdehyde; D005978:Glutathione