Promising new therapies for Behcet's disease.
Improved understanding of the pathogenic mechanisms of Behcet's disease (BD), and especially of the molecular basis involved in its pathogenesis, has sparked a new generation of potential BD treatments with improved side effect profiles and/or more specific targeting of the immune system. These therapies include new immunosuppressants, biologic medications, tolerizing agents, and immunoablation techniques, a number of which are currently in use in clinical practice (interferons). While some of these new therapies target specific inflammatory mechanisms in SLE (tumor necrosis factor-alpha inhibitors), others work by non-specific inhibition of the immune system (immunoablation). Each of these approaches will be discussed in this review.
Houman
M H
MH
Department of Internal Medicine, La Rabta University Hospital and Behçet's Disease Unit Research 02/UR/08-15, Faculty of Medicine, 1007 Tunis, Tunisia.
Hamzaoui
K
K