title: The pharmacokinetic behaviour of marbofloxacin in Eurasian buzzards (Buteo buteo) after intraosseous administration.
abstract: This study reports on the administration of a single dose of marbofloxacin (2 mg/kg) to five adult Eurasian buzzards (Buteo buteo) by the intraosseous (IO) route, which has been proposed as a rapid and efficient means for the parenteral delivery of antimicrobial drugs. The drug was rapidly absorbed. Peak marbofloxacin concentration (C(max)) in plasma and area under the concentration-time curve (AUC) of 1.92+/-0.78 microg/mL and 8.53+/-2.73 microg h/mL, respectively. The time marbofloxacin remained in the plasma after IO administration was relatively short (elimination half-life, t(1/2beta)=4.91+/-0.65 h; mean residence time (MRT)=5.38+/-0.57 h). Single dose marbofloxacin gave values for C(max)/minimum inhibitory concentration (MIC) of 19.2 and an AUC/MIC value of 85.3h after IO administration. The IO route appears to be practical and effective for the rapid delivery of marbofloxacin to buzzards.
authors.affiliation: AULAGA, Centro de Cria del Aguila Imperial, Ibérica Quintos de Mora, Ministerio de Medio Ambiente, Toledo, Spain.
authors.forename: Marino
authors.initials: M
authors.lastname: Garcia-Montijano
authors.forename: Samanta
authors.initials: S
authors.lastname: Waxman
authors.forename: J Julio de
authors.initials: JJ
authors.lastname: Lucas
authors.forename: Inés
authors.initials: I
authors.lastname: Luaces
authors.forename: Javier
authors.initials: J
authors.lastname: Zalba
authors.forename: Fernando
authors.initials: F
authors.lastname: González
authors.forename: Manuel I San
authors.initials: MI
authors.lastname: Andrés
authors.forename: Casilda
authors.initials: C
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D006207:Half-Life; D017148:Infusions, Intraosseous / Q000379:methods / Q000662:veterinary*; D015363:Quinolones / Q000493:pharmacokinetics*; D020304:Raptors
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin