title: In vivo brain microdialysis studies on the striatal dopamine and serotonin release in zitter mutant rats.
abstract: In the present study, using in vivo brain microdialysis, we investigated the basal extracellular dopamine (DA) and serotonin (5-HT) release in the caudal striatum (cSTR) of young (4-6 months old) and aged (10-12 months old) zitter mutant rats. The basal extracellular levels of DA release in both young and aged zitter rats were significantly lower than that of age-matched Sprague-Dawley (SD) rats, whereas only aged zitter rats showed a significant difference in the basal 5-HT release. Dopaminergic neurons were more vulnerable than serotonergic neurons in the cSTR of zitter mutant rats during aging. Perfusion of 60 mM potassium (K+) enhanced the extracellular levels of cSTR DA in the young zitter rats and the extracellular levels of both DA and 5-HT in the cSTR of the aged zitter rats. The firing rate of K+-stimulated monoamine release in the cSTR was significantly higher in the zitter rats than in the age-matched SD rats. These findings suggest that there are innate quantitative differences in the releasable pool and the availability of monoamines in the cSTR of zitter mutant rats.
authors.affiliation: Department of Legal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo-ku, Kyoto 602-8566, Japan. kyoshimo@koto.kpu-m.ac.jp
authors.forename: Kanji
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Nishimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hattori
authors.forename: Jeffery N
authors.initials: JN
authors.lastname: Joyce
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chizuko
authors.initials: C
authors.lastname: Hioki
authors.forename: Akinori
authors.initials: A
authors.lastname: Kogure
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ueda
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism; D017551:Microdialysis; D010291:Paresis / Q000235:genetics / Q000378:metabolism; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D014202:Tremor / Q000235:genetics / Q000378:metabolism
chemical_list: D011188:Potassium; D004298:Dopamine