New concepts in the treatment of brain tumors in very young children.
The treatment of brain tumors in infants (children <3 years of age) in the last 15-20 years has been a special field of interest for clinical investigation and research, since infants affected by brain tumors are an ideal experimental group of patients. New treatment strategies (conventional, myeloablative and intraventricular chemotherapy) have been tested on these patients in an effort to avoid or delay conventional irradiation. The amazing amount of knowledge that has been acquired from neuropathological and biological studies, as well as from the first generation treatment baby protocols, which were designed between 1985 and 2000, is now leading to a new approach whereby treatment strategies are tailored to the patient's clinicopathological features.
Garre'
Maria Luisa
ML
Neuro-Oncology Unit, Hemato-Oncology Department, Giannina Gaslini Children's Research Hospital (IGG), Largo G. Gaslini 5, 16148 Genova, Italy. GARREMA@iol.it
Cama
Armando
A
Milanaccio
Claudia
C
Gandola
Lorenza
L
Massimino
Maura
M
Dallorso
Sandro
S
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy*; D002675:Child, Preschool; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
D000970:Antineoplastic Agents