title: Molluscicidal activity and new flavonoids from Egyptian Iris germanica L. (var. alba).
abstract: The molluscicidal activity of leaf and rhizome extracts of Iris germanica L. (var. alba) against Biomphalaria alexandrina snails was evaluated and the rhizome extracts were found to be the most potent. Activity-guided fractionation revealed that the chloroform extract showed the highest molluscicidal activity (LC90 = 1.26 mg/l) among the tested extracts of the rhizomes. Fraction B prepared from the chloroform extract was the most potent molluscicide (LC90 = 0.96 mg/l) in addition, it showed a significant heart rate reduction in the snail after a 6- to 24-h exposure period. It also displayed a significant level of cercaricidal potential in a time-concentration relationship pattern. Chromatographic fractionation and purification of fraction B resulted in the isolation of two novel compounds: 5,2'-dihydroxy-3-methoxy-6,7-methylenedioxyflavone and 5,7,2'-trihydroxy-6-methoxyflavanone. Their structures were established by one- and two-dimensional NMR methods and mass spectrometry.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt. singo562002@yahoo.com
authors.forename: Abdel Nasser B
authors.initials: AN
authors.lastname: Singab
authors.forename: Amer H
authors.initials: AH
authors.lastname: Ahmed
authors.forename: Jari
authors.initials: J
authors.lastname: Sinkkonen
authors.forename: Vladimir
authors.initials: V
authors.lastname: Ovcharenko
authors.forename: Kalevi
authors.initials: K
authors.lastname: Pihlaja
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D004534:Egypt; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D035264:Flowers; D006339:Heart Rate / Q000187:drug effects; D031323:Iris Plant / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012621:Seasons
chemical_list: D005419:Flavonoids