title: Improved survival of patients with ovarian cancer in Northern Denmark, 1985-2004.
abstract: OBJECTIVE
  Ovarian cancer is a serious disease with a high mortality. Our aim was to examine changes in the survival of patients with ovarian cancer in Northern Denmark.
  
  
  METHODS
  Patients (no. = 3,719) with an incident discharge diagnosis of ovarian cancer (1985-2004) from any hospital in four Danish counties (population, 1.6 million) were included and tracked for mortality through the Danish Civil Registration System. We determined survival and mortality rates stratified by age, and used Cox proportional hazard regression analyses to assess changes over time.
  
  
  RESULTS
  Overall survival rate improved between 1985 and 2004. One-year survival increased from 61% to 73%, and five-year survival from 30% to 38%. Compared with the period 1985-1989 the age-adjusted one-year mortality rate ratio (MRR) was 0.65 (2000-2004) and the age-adjusted five-year MRR was 0.80 (1995-1999). The improvement was most pronounced in patients older than 40 years.
  
  
  CONCLUSIONS
  The survival of ovarian cancer patients has improved in Denmark in recent decades. This change may be the result of improved treatment.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: M S
authors.initials: MS
authors.lastname: Tetsche
authors.forename: M
authors.initials: M
authors.lastname: Nørgaard
authors.forename: J
authors.initials: J
authors.lastname: Jacobsen
authors.forename: E S
authors.initials: ES
authors.lastname: Andersen
authors.forename: P
authors.initials: P
authors.lastname: Lundorff
authors.forename: J
authors.initials: J
authors.lastname: Blaakaer
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000368:Aged; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000401:mortality*; D016016:Proportional Hazards Models; D012042:Registries; D015996:Survival Rate / Q000639:trends; D013997:Time Factors