First two successful unrelated donor bone marrow transplantations for paroxysmal nocturnal hemoglobinuria in Poland.
OBJECTIVE
The experience with bone marrow transplantation (BMT) from matched unrelated donors (MUD) for paroxysmal nocturnal hemoglobinuria (PNH) is limited and optimal preparative regimen has been not established.


METHODS
We report first two MUD BMTs for patients with PNH in Poland. Preparative regimen consisted of Treosulfan, Fludarabine and Thymoglobulin. We also present the review of published reports on allogeneic transplantations for PNH and discuss important transplant-related issues.


RESULTS
Both patients are alive and are doing well over 12 and over 4 months following BMT. Regeneration is complete with full 100% donor chimerism and the eradication of PNH clone.


CONCLUSIONS
MUD BMT is an effective treatment for PNH. Treosulfan, Fludarabine and Thymoglobulin treatment can be safely and effectively used for conditioning in PNH.
Markiewicz
Mirosław
M
Department of Hematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland. mir.markiewicz@wp.pl
Wojciechowska
Maria
M
Wylezoł
Iwona
I
Giebel
Sebastian
S
Woźniczka
Krzysztof
K
Wojnar
Jerzy
J
Mendek-Czajkowska
Ewa
E
Hołowiecki
Jerzy
J
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D011044:Poland; D019172:Transplantation Conditioning; D016896:Treatment Outcome