title: Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study.
abstract: A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child Health and Human Development, to compare the family history of autoimmune disorders in children with ASD with and without a history of regression. A history of regression was determined from the results of the Autism Diagnostic Interview-Revised (ADI-R). Family history of autoimmune disorders was obtained by telephone interview. Regression was significantly associated with a family history of autoimmune disorders (adjusted OR=1.89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41).
authors.affiliation: Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229-3039, USA. cynthia.molloy@cchmc.org
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Molloy
authors.forename: Ardythe L
authors.initials: AL
authors.lastname: Morrow
authors.forename: Jareen
authors.initials: J
authors.lastname: Meinzen-Derr
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
authors.forename: Raphael
authors.initials: R
authors.lastname: Bernier
authors.forename: Michelle
authors.initials: M
authors.lastname: Dunn
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hyman
authors.forename: William M
authors.initials: WM
authors.lastname: McMahon
authors.forename: Julie
authors.initials: J
authors.lastname: Goudie-Nice
authors.forename: Susan
authors.initials: S
authors.lastname: Hepburn
authors.forename: Nancy
authors.initials: N
authors.lastname: Minshew
authors.forename: Sally
authors.initials: S
authors.lastname: Rogers
authors.forename: Marian
authors.initials: M
authors.lastname: Sigman
authors.forename: M Anne
authors.initials: MA
authors.lastname: Spence
authors.forename: Helen
authors.initials: H
authors.lastname: Tager-Flusberg
authors.forename: Fred R
authors.initials: FR
authors.lastname: Volkmar
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D012043:Regression, Psychology; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000235:genetics / Q000523:psychology