Synthesis and evaluation of fluorine-18 labelled compounds for imaging of bacterial infections with pet.
Syntheses of no carrier added (n.c.a.) 6-fluoro-1,4-dihydro-1-cyclopropyl-4-oxo-7-[4-[18F]fluoro-phenacyl-1-piperacinyl]-chinolincarboxylic acid ([18F]COPCA) and n.c.a. 4-[18F]fluoro-benzoyl-ubiquicidin 29-41 ([18F]UBI 29-41) are described. [18F]COPCA was synthesised within 120 min with a radiochemical yield of 9-12%. [18F]UBI 29-41 was synthesised within 150 min with a radiochemical yield of 15-20%. Both compounds had a specific activity of more than 35 GBq/micromol. The biological activity was verified by measuring its binding to Staphylococcus aureus bacteria. Specific binding was found for [18F]UBI 29-41 (12-17%), whereas no specific binding for [18F]COPCA was found.
Zijlstra
S
S
Institut für Molekulare Biophysik, Radiopharmazie und Nuklearmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitaetsklinik der Ruhr-Universitaet, Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany. szijlstra@hdz-nrw.de
Gunawan
J
J
Freytag
C
C
Burchert
W
W
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000138:chemical synthesis*; D015363:Quinolones / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012269:Ribosomal Proteins / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*
D000900:Anti-Bacterial Agents; D005462:Fluorine Radioisotopes; D010879:Piperazines; D015363:Quinolones; D019275:Radiopharmaceuticals; D012269:Ribosomal Proteins; C040469:ribosomal protein S30