NMR diffusion and nuclear Overhauser investigation of the hydration properties of thymine: influence of the methyl group.
The absence of preferential hydration in thymine and its lowest water accessibility with respect to uracil were evidenced by NMR diffusion and HOESY experiments; the hydration differences observed between these pyrimidine bases were attributed to the electronic rather than steric properties of the methyl group.
Thureau
Pierre
P
Jeune Equipe 2421 TRACES, Université de Provence et Paul Cézanne, case 512, Centre de St Jérôme, 13397 Marseille cedex 20, France. pierre.thureau@univ.u-3mrs.fr
Ancian
Bernard
B
Viel
Stéphane
S
Thévand
André
A
D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D013941:Thymine / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D014867:Water; D013941:Thymine