title: [A preliminary study of beam weight optimization of intensity-modulated radiation therapy with genetic algorithm].
abstract: To study the method for dose calculation and beam weight optimization of intensity-modulated radiation therapy (IMRT).
  
  
  METHODS
  The IMRT dose calculation model based on two-dimensional convolution was constructed, the program of dose calculation and beam weight optimization with genetic algorithm was written with Visual c#.Net, and the optimization results were analyzed.
  
  
  RESULTS
  Genetic algorithm optimization of beam weights can produce highly conformal dose distributions within a clinically acceptable computation time.
  
  
  CONCLUSIONS
  Genetic algorithm is valid and efficient in IMRT beam weight optimization, which may facilitate IMRT treatment planning.
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Mu-tao
authors.initials: MT
authors.lastname: Tang
authors.forename: Chao-min
authors.initials: CM
authors.lastname: Chen
authors.forename: Ling-hong
authors.initials: LH
authors.lastname: Zhou
authors.forename: Qing-wen
authors.initials: QW
authors.lastname: Lü
authors.forename: Zhuo-yu
authors.initials: ZY
authors.lastname: Wang
authors.forename: Guang-jie
authors.initials: GJ
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods* / Q000592:standards