ACE inhibition and glomerular repair: restructuring or regeneration?
In this issue of Kidney International, Andrea Remuzzi et al. convincingly demonstrate glomerular repair in spontaneous renal disease by ACE inhibition. These findings provoke questions about how ACE inhibition (or AT1R blockade) can on the one hand actually repair some diseased kidneys while on the other interfering with normal renal development or the recovery of other diseased kidneys.
Joles
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JA
Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands. J.A.Joles@med.uu.nl
Braam
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Verhaar
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D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy*; D007678:Kidney Glomerulus / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors