title: Downregulation of selected cytokines in amebiasis.
abstract: A 220-kDa E. histolytica lectin is capable of downregulating some inflammatory cytokines (IL-5, IL-6, INF-gamma and TNF-alpha) and thus of inducing an overall anti-inflammatory Th-phenotype in leucocytes of selected, perhaps constitutionally predisposed, individuals irrespective of their HLA-DR3 profile (i.e., in this study patients long recovered from amebic abscess of the liver). This probably inhibited cytokine response pattern could increase the risk for developing amebic abscess of the liver in the course of invasive intestinal amebiasis.
authors.affiliation: Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, CMN-Siglo XXI, IMSS, México, DF, México.
authors.forename: Vilma Carolina
authors.initials: VC
authors.lastname: Bekker-Mendez
authors.forename: Viola Leticia
authors.initials: VL
authors.lastname: Pérez-Castillo
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Rico-Rosillo
authors.forename: Martha
authors.initials: M
authors.lastname: Pérez-Rodríguez
authors.forename: Jorge
authors.initials: J
authors.lastname: Arellano-Blanco
authors.forename: Roberto Rodolfo
authors.initials: RR
authors.lastname: Kretschmer-Schmid
authors.forename: Patricia
authors.initials: P
authors.lastname: Talamás-Rohana
mesh_terms: D000562:Amebiasis / Q000378:metabolism* / Q000469:parasitology; D000656:Amoeba / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D007962:Leukocytes / Q000378:metabolism
chemical_list: D016207:Cytokines