title: Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ?
abstract: The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis (UC) or Crohn's disease (CD) or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors (e.g. NOD2/CARD15, SLC22A46A5 and DLG5). The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.
authors.affiliation: 1st Department of Medicine, Semmelweis University, Koranyi str. 2/A, H-1083 Budapest, Hungary. kislakpet@bell.sote.hu
authors.forename: Peter Laszlo
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Simon
authors.initials: S
authors.lastname: Fischer
authors.forename: Laszlo
authors.initials: L
authors.lastname: Lakatos
authors.forename: Istvan
authors.initials: I
authors.lastname: Gal
authors.forename: Janos
authors.initials: J
authors.lastname: Papp
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000502:physiology; D016360:Clostridioides difficile / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D004926:Escherichia coli / Q000502:physiology; D005786:Gene Expression Regulation; D006680:HLA Antigens / Q000235:genetics / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000382:microbiology* / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000382:microbiology / Q000503:physiopathology*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D007778:Lactobacillus / Q000502:physiology; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D016927:Mycobacterium avium subsp. paratuberculosis / Q000502:physiology; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D027701:Organic Cation Transport Proteins / Q000235:genetics / Q000502:physiology; D020239:Receptor Cross-Talk; D000074058:Solute Carrier Family 22 Member 5; D027981:Symporters; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000502:physiology; D051193:Toll-Like Receptors / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; C114461:DLG5 protein, human; D006680:HLA Antigens; D047908:Intracellular Signaling Peptides and Proteins; D018950:Lipopolysaccharide Receptors; D008565:Membrane Proteins; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D027701:Organic Cation Transport Proteins; C109807:SLC22A4 protein, human; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5; D027981:Symporters; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D025521:Tumor Suppressor Proteins