Serum concentrations of MMP-1, MMP-2, and TIMP-1 in Chinese women: age-related changes, and the relationships with bone biochemical markers, bone mineral density.
BACKGROUND
Osteoblast-derived matrix metalloproteinse-1 (MMP-1), MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) play a role in bone metabolism by degrading bone matrix.


METHODS
We measured MMP-1, MMMP-2, TIMP-1 and associated results with age and bone metabolism in 591 Chinese women aged 20-80 y.


RESULTS
Serum MMP-1, MMP-2, and TIMP-1 concentrations exhibited positive correlation with age. Serum concentrations of MMP-1 were higher in 40-69 y old women. The concentrations of MMP-2 were significantly increased in the 50-69 y olds. Serum TIMP-1 concentrations were significantly lower in women aged 30-59 y, and then these were followed by an increase at >60 y olds. We found a significant negative weaker correlation between MMP-2 and BMD. But multiple linear stepwise regression analysis showed that MMP-2 was not a determinant factor for BMD. There were significant positive correlations between MMP-2 and bone alkaline phosphatase (BAP), osteocalcin (OC), and cross-linked N-telopeptides of type I collagen (NTX).


CONCLUSIONS
The serum concentrations of MMP-1, MMP-2, and TIMP-1 exhibit age-related changes, and circulating MMP-2 and bone turnover are related.
Guo
Li-Juan
LJ
Institute of Endocrinology and Metabolism, The Second Xiang-Ya Hospital of Central South University, 86# Middle Renmin Road, Changsha, Hunan 410011, PR China.
Luo
Xiang-Hang
XH
Wu
Xian-Ping
XP
Shan
Peng-Fei
PF
Zhang
Hong
H
Cao
Xing-Zhi
XZ
Xie
Hui
H
Liao
Er-Yuan
EY
D000328:Adult; D000367:Age Factors; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000201:enzymology; D002681:China; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; D019715:Tissue Inhibitor of Metalloproteinase-1; D019714:Tissue Inhibitor of Metalloproteinases; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1