title: A concise and selective synthesis of novel 5-aryloxyimidazole NNRTIs.
abstract: [reaction: see text] A concise and efficient route to the construction of a 5-aryloxyimidazole has been developed. The key step was the selective O-arylation of a 2,4-dimethoxybenzyl-protected imidazolone. The final compound is a potent inhibitor of HIV reverse transcriptase.
authors.affiliation: Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. lyn.jones@pfizer.com
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
authors.forename: Thomas
authors.initials: T
authors.lastname: Dupont
authors.forename: Charles E
authors.initials: CE
authors.lastname: Mowbray
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Newman
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis*; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D007093:Imidazoles; D018894:Reverse Transcriptase Inhibitors; D013457:Sulfur Compounds; C433874:capravirine