Relationship between immune cell phenotypes and pig growth in a commercial farm.
The objective of this study was to evaluate the relationship between the level and function of circulating immune cells with average daily gain, live and carcass measurements, feed intake, and feed conversion. Production performance was monitored throughout the pig's lifetime. Pigs were moved in weekly batches through the nursery and growing/finishing rooms at specific target weights. Animals were individually weighed at birth and at weaning, and then every two weeks while they were "on test" until they were "off test" and sent to the slaughterhouse. At six to seven weeks of age, the pigs were bled in the nursery. The percentage of immune cell subsets and lymphocyte proliferation was estimated using swine monoclonal antibodies and flow cytometric analysis. The predictive effect of the immune cell subset markers and lymphocyte proliferation on production traits was statistically analyzed. The results indicated that the proportion of several peripheral cell subsets, including CD16+, CD2+/CD16+, and CD8+ lymphocytes, appear to predict growth during the entire productive life of the pig. Larger percentages of lymphocytes expressing CD16+ CD2+/CD16+, and CD8+receptors in blood resulted in a reduction in average daily gain. In addition, high percentages of SLA-DQ+ cells were associated with better carcass weight and feed conversion. The CD16+, CD2+/CD16+, CD8+, and SLA-DQ+/- cell subsets appear to be important biomarkers involved with the inherent ability of the pig to efficiently grow and produce better carcass weight in representative commercial environments.
Galina-Pantoja
L
L
Sygen International/PIC, 3033 Nashville Road, Franklin, Kentucky 42135, USA. Luciana.Galina@pic.com
Mellencamp
M A
MA
Bastiaansen
J
J
Cabrera
R
R
Solano-Aguilar
G
G
Lunney
J K
JK
D000818:Animals; D000831:Animals, Newborn; D015703:Antigens, CD / Q000276:immunology; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D006649:Histocompatibility Antigens / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D013552:Swine / Q000254:growth & development* / Q000276:immunology*; D015430:Weight Gain
D015703:Antigens, CD; D006649:Histocompatibility Antigens