title: Operating characteristics of the Finapress system to predict elevated left ventricular filling pressure.
abstract: BACKGROUND
  Dyspnea is a common symptom and can be caused by many different conditions. The detection of congestive heart failure (CHF) is sometimes difficult.
  
  
  OBJECTIVE
  The pulse amplitude ratio (PAR) measured by the Finapress procedure during a Valsalva maneuver can detect elevated left ventricular end-diastolic pressure (LVEDP) accurately over a wide range of values.
  
  
  METHODS
  Comparison of the estimated LVEDP by PAR with the invasively measured LVEDP before and after ventriculography during coronography was made in 101 consecutive stable patients referred for chest pain and/or chronic dyspnea.
  
  
  RESULTS
  A significant correlation was found between the catheter-measured LVEDP (range 3-40 mmHg) and the PAR (R2 = 0.70, p < 0.001). The receiver operator characteristics (ROC) of the PAR to detect an LVEDP > 15 mmHg can be considered to be excellent, with an area under the ROC curve achieving 0.92 (95% confidence interval [CI] 0.87-0.96; p < 0.001). A PAR of > 0.675 predicted the presence of an LVEDP > 15 mmHg with a sensitivity of 0.865 (95% CI 0.780-0.926) and a specificity of 0.847 (95% CI 0.730-0.928). The positive and negative LRs were 5.70 and 0.16, respectively.
  
  
  CONCLUSIONS
  The observed likelihood ratios confirm that the PAR determined by the Finapress procedure may be a useful bedside diagnostic tool in patients with cardiac conditions.
authors.affiliation: Service of Cardiology, CHU A. Vesale, Montigny-le-Tilleul, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Gillard
authors.forename: C
authors.initials: C
authors.lastname: Henuzet
authors.forename: J
authors.initials: J
authors.lastname: Lallemand
authors.forename: A
authors.initials: A
authors.lastname: Moscariello
authors.forename: M
authors.initials: M
authors.lastname: Guillaume
authors.forename: A
authors.initials: A
authors.lastname: Van Meerhaeghe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination / Q000295:instrumentation*; D016022:Case-Control Studies; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology; D015331:Cohort Studies; D017023:Coronary Angiography; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume; D014636:Valsalva Maneuver; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*; D017725:Ventricular Pressure / Q000502:physiology*