title: Gene therapy for HIV infection: what does it need to make it work?
abstract: The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved. This review focuses on the determinants of therapeutic efficacy and discusses the potential and also the limits of current gene therapy approaches for HIV infection.
authors.affiliation: Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42, Frankfurt a.M., Germany. laer@em.uni-frankfurt.de
authors.forename: Dorothee
authors.initials: D
authors.lastname: von Laer
authors.forename: Susanne
authors.initials: S
authors.lastname: Hasselmann
authors.forename: Klaus
authors.initials: K
authors.lastname: Hasselmann
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics; D015658:HIV Infections / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000998:Antiviral Agents