[Effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice].
OBJECTIVE
To explore the effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice.


METHODS
The 80 Balb/c mice were randomly divided into eight groups, the normal control group, the high iodine group (drunk the water containing iodine 3000 microg/L) and six selenium groups (drunk the water containing iodine 3000 microg/L and selenium 0.1, 0.2, 0.3, 0.4, 0.5, 0.75 mg/L). The total cholesterol and triglyceride in serum and liver were determined.


RESULTS
The total cholesterol in serum, the total cholesterol and triglyceride in liver of high-iodine group increased significantly compared with normal control group. There is no difference between normal control group and the group drunk the water contained 0.2 mg/L selenium.


CONCLUSIONS
It suggests that it is an effective intervention dosage to drunk water containing 0.2 mg/L selenium.
Xu
Jian
J
Department of Nutrition and Hygiene, School of Public Health, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China.
Yang
Xue-Feng
XF
Guo
Huai-Lan
HL
Hou
Xiao-Hui
XH
Chen
Xiaoyi
X
Sun
Xiufa
X
D000818:Animals; D005260:Female; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D052439:Lipid Metabolism Disorders / Q000097:blood / Q000139:chemically induced*; D008055:Lipids / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D012643:Selenium / Q000008:administration & dosage* / Q000494:pharmacology*
D008055:Lipids; D007455:Iodine; D012643:Selenium