title: [Bronchiectasis worsening by p-ANCA (bactericidal/permeability-increasing protein) positive vasculitis. A case report and review of the literature].
abstract: A 67-year-old woman was hospitalized with recurrent fever, arthralgia and erythema of the arms and legs. She had suffered from bronchiectasis for the previous 4 years, and Pseudomonas was persistently detected in her sputum. During the course of her illness, she developed distal sensitive and motor polyneuropathy. Serum test was positive for myeloperoxidase and bactericidal/permeability-increasing protein antineutrophil cytoplasmic antibodies. Nerve biopsy showed vasculitis infiltration of the vasa nervorum. She started immunoglobulin therapy, and after methylprednisolone and pulse cyclophosphamide therapy once monthly for 6 months she showed a good response and a reduction in symptoms.
authors.affiliation: Sezione di Reumatologia, Dipartimento di Medicina Interna, Nuovo Ospedale San Giovanni di Dio di Firenze. maubenucci@tiscali.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Benucci
authors.forename: Gabriele
authors.initials: G
authors.lastname: Nenci
authors.forename: Gianni
authors.initials: G
authors.lastname: Taccetti
authors.forename: Aurelio
authors.initials: A
authors.lastname: Rosso
authors.forename: Chiara
authors.initials: C
authors.lastname: Beltrame
authors.forename: Carlo
authors.initials: C
authors.lastname: Cappelletti
authors.forename: Mariangela
authors.initials: M
authors.lastname: Manfredi
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000276:immunology*; D001987:Bronchiectasis / Q000150:complications*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology*; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008565:Membrane Proteins; C021623:bactericidal permeability increasing protein