Are estrogen receptor content in breast cancer and effects of tamoxifen on sex hormone-binding globulin markers for individual estrogen sensitivity?
Individual women differ with respect to their sensitivity to estrogen and serum levels of sex hormone-binding globulin (SHBG) may reflect the individual response. We found a significant correlation between estrogen receptor (ER) concentrations in breast cancer tissue and SHBG levels during tamoxifen treatment. Estrogen sensitivity may be a general characteristic common to various organs and different between individual women.
Löfgren
L
L
Department of Surgery, Capio St. Görans Hospital, and Department of Oncology, Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden. lars.lofgren@capio.se
von Schoultz
E
E
Fernstad
R
R
von Schoultz
B
B
Carlström
K
K
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000378:metabolism*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology*
D014408:Biomarkers, Tumor; D004967:Estrogens; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D012738:Sex Hormone-Binding Globulin; D013629:Tamoxifen