title: Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans.
abstract: OBJECTIVE
  Search for plant compounds possessing anti-leukemic properties.
  
  
  RESULTS
  We have shown that 5-hydroxy-7-methoxy flavanone (pinostrobin) isolated from Polygonum lapathifolium ssp. nodosum quickly penetrates through cytoplasm to the cellular nucleus of the cultured cells, and gives intensive apoptotic response in stimulating leukemic cells in vitro. The number of apoptotic cells increased with the concentration of pinostrobin: 10 nM - 25% and 60%; 100 nM - 45% and 76%; 1 microm - 70% and 88% for Jurkat and HL60 cell lines, respectively
  
  
  CONCLUSIONS
  Pinostrobin may be considered as a good candidate for a leukemia chemopreventic agent.
authors.affiliation: Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland. smolarz@am.lublin.pl
authors.forename: Helena D
authors.initials: HD
authors.lastname: Smolarz
authors.forename: Ewaryst
authors.initials: E
authors.lastname: Mendyk
authors.forename: Anna
authors.initials: A
authors.lastname: Bogucka-Kocka
authors.forename: Janusz
authors.initials: J
authors.lastname: Kocki
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D019169:Jurkat Cells; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones; D010936:Plant Extracts; C411294:pinostrobin