Synergy of arbekacin-based combinations against vancomycin hetero-intermediate Staphylococcus aureus.
This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinupristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillin-sulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.
Lee
Ji Young
JY
Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Korea.
Oh
Won Sup
WS
Ko
Kwan Soo
KS
Heo
Sang Taek
ST
Moon
Chi Sook
CS
Ki
Hyun Kyun
HK
Kiem
Sungmin
S
Peck
Kyong Ran
KR
Song
Jae Hoon
JH
D000617:Aminoglycosides / Q000008:administration & dosage*; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003982:Dibekacin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013407:Sulbactam / Q000008:administration & dosage; D017334:Teicoplanin / Q000008:administration & dosage; D014640:Vancomycin / Q000008:administration & dosage*; D014769:Virginiamycin / Q000008:administration & dosage
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D003982:Dibekacin; D017334:Teicoplanin; C035444:sultamicillin; D014640:Vancomycin; D000667:Ampicillin; C031986:arbekacin; D013407:Sulbactam