[Renal function outcome in acute myocardial infarction as a prognostic factor of in-hospital events and at one-year follow-up].
OBJECTIVE
To analyze the role of renal dysfunction at admission or during hospitalization in patients with acute myocardial infarction (AMI).


METHODS
Two hundred and seventy-four patients with AMI were assessed between January 2000 and December 2001. Renal function was monitored by serum creatinine (Cr) measurement at admission and peak level during hospitalization. Creatinine clearance (CrCl) was estimated by the Cockcroft-Gault formula. In-hospital and one-year morbidity and mortality were evaluated.


RESULTS
Mean age of the population studied was 62.2 +/- 13.5, and 73% of the patients were male. Renal function was more reduced in male patients and in those with systemic arterial hypertension and prior CABG. Multivariate analysis showed higher hospital mortality rates associated with increased peak serum Cr levels (OR: 1.18 95% CI: 1.18-2.77 p = 0.006), decreased baseline CrCl (OR: 0.96 95% CI: 0.93-0.99 p = 0.025) and peak CrCl (OR: 0.96 95% CI: 0.92-0.99 p = 0.023). Percent difference between baseline CrCl and the lowest CrCl obtained during hospitalization also indicated higher mortality rates (OR: 1.04 95% CI: 1.00-1.07 p = 0.033). No change was observed in the one-year morbidity and mortality from worsening of renal function.


CONCLUSIONS
Renal dysfunction at admission and its deterioration during hospitalization have proved to be a major prognostic marker for immediate poor outcome.
Pimenta
Eduardo
E
Instituto Dante Pazzanese de Cardiologia, São Paulo, SP. espimenta@cardiol.br
Ramos
Rui Fernando
RF
Gun
Carlos
C
Santos
Elizabeth S
ES
Timerman
Ari
A
Piegas
Leopoldo S
LS
D017677:Age Distribution; D000368:Aged; D003404:Creatinine / Q000097:blood; D004812:Epidemiologic Methods; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology*; D011379:Prognosis; D051437:Renal Insufficiency / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology*; D017678:Sex Distribution
D003404:Creatinine