[Study on immunorepressive mice model by gamma irradiation].
OBJECTIVE
To establish the immunorepressive mice model by irradiation.


METHODS
The 90 Kunming mice which the weight is from 30 to 34g were treated with 3Gy, 4Gy, 5Gy gamma irradiation, the delayed allergy testing, the serum haemolysin level testing, the phagocytosing functions testing and the NK cell activity testing were performed at 3th, 7th, 14th, 21th days after irradiation respectively.


CONCLUSIONS
(1) All 3Gy, 4Gy, 5Gy gamma irradiation can cause mice immunorepressivestate except the NK cell activity. (2) The time of comeback after irradiation is different from immunity items. The serum haemolysin level is most sensitivity in all, but it comeback most slowly after irradiation. The phagocytosing functions comeback most rapidly after irradiation. (3) It suggests that the irradiation immunorepressive mice model can be established using it in order to evaluate the enhanceing immune function, assisting irradiation hazard protection function and alleviating toxicity function of irradiation treatment and chemical treatment. (4) The NK cell activity is not suitably to immunorespressive by gamma irradiation.
Li
Ye-Peng
YP
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Li
Yan-Jun
YJ
Han
Chun-Hui
CH
Li
Yu-Wei
YW
Zhao
Xi
X
Jiang
Tao
T
Zhong
Kai
K
Zhang
Jing
J
Chen
Tingjun
T
Ji
Rong
R
D000818:Animals; D005720:Gamma Rays; D007107:Immune System / Q000276:immunology / Q000528:radiation effects*; D016867:Immunocompromised Host / Q000276:immunology*; D008297:Male; D051379:Mice; D023421:Models, Animal; D011897:Random Allocation; D014916:Whole-Body Irradiation