[The method of conditioned place preference in pharmaco-dependence research].
Conditioned place preference (CPP) is a paradigm for evaluating pharmaco-dependence related issues besides other animal models (withdrawal syndrome evaluation, self administration, behavioural sensitisation, drug discrimination). CPP is used for evaluation of motivational properties of substances (but also for non pharmacological stimulus). It consists in repeated association between a primary unconditioned properties of a stimulus (usually a substance) with a distinct environment. After a number of such associations, the unconditioned stimulus become conditioned stimulus and may emerge a response when the animal is exposed to these (the conditioned compartment). The response may be quantified as the time spent in the conditioned compartment. Our studies show an agreement between misoprostol (stable PGE1 analogue) effect on alleviating morphine-induced experimental pharmaco-dependence and morphine-induced CPP.
Chelărescu
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Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină Dentară, Disciplina de Farmacologie.
Nechifor
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M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D016595:Misoprostol / Q000008:administration & dosage / Q000494:pharmacology*; D023421:Models, Animal; D009021:Morphine Dependence; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D012054:Reinforcement, Psychology; D013375:Substance Withdrawal Syndrome
D009294:Narcotics; D016595:Misoprostol