Influence of hypothyroidism induced by thiamazole on the toxicity of amitriptyline in chick embryos.
The effect of hypothyroidism induced by thiamazole on the toxicity of amitriptyline was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubation. The control group was given 0.2 ml/egg of physiological saline in the same manner. Amitriptyline at 1 mg/egg was injected into the air sac of fertilized eggs on the 16th day of incubation. Electrocardiograms were recorded 0 to 60 min after the injection. After the injection of amitriptyline into the thiamazole-treated eggs, the heart rate was significantly decreased compared with the untreated eggs. These findings indicate that hypothyroidism induced by thiamazole has a marked influence on the toxicity of amitriptyline in chick embryos.
Yoshiyama
Yuji
Y
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, Shibakoen, Tokyo, Japan. yoshiyama-yj@kyoritsu-ph.ac.jp
Kanke
Motoko
M
D000639:Amitriptyline / Q000633:toxicity*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D013956:Antithyroid Agents; D001835:Body Weight / Q000187:drug effects; D002642:Chick Embryo; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007037:Hypothyroidism / Q000139:chemically induced* / Q000378:metabolism*; D008713:Methimazole
D000929:Antidepressive Agents, Tricyclic; D013956:Antithyroid Agents; D000639:Amitriptyline; D008713:Methimazole