Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation.
We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation. The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.
Quincoces
Gemma
G
Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av. Pío XII 36,31008 Pamplona, Spain.
Peñuelas
Iván
I
Valero
Marta
M
Serra
Patricia
P
Collantes
María
M
Martí-Climent
Josep
J
Arbizu
Javier
J
García-Velloso
María José
MJ
Richter
José Angel
JA
D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D002851:Chromatography, High Pressure Liquid; D008715:Methionine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008745:Methylation; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline