Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions.
Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.
de Lemos
Mário L
ML
British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada. mdelemos@bccancer.bc.ca
Hamata
Linda
L
Vu
Thanh
T
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D004051:Diethylhexyl Phthalate / Q000737:chemistry*; D004340:Drug Contamination / Q000517:prevention & control; D004349:Drug Packaging / Q000379:methods*; D005047:Etoposide / Q000008:administration & dosage / Q000737:chemistry*; D007262:Infusions, Intravenous; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*; D012995:Solubility
D000972:Antineoplastic Agents, Phytogenic; D019999:Pharmaceutical Solutions; D005047:Etoposide; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate