[Expression of epidermal growth factor receptor-2 in Chinese breast cancer patients: a meta-analysis].
OBJECTIVE
To study the expression of cerbB-2 and its clinical biology value in Chinese breast cancer patients by evidence based medical analysis.


METHODS
All the published studies about cerbB-2 and breast cancer for the last 10 years were reviewed and standard techniques of meta-analysis to combined with the results of these studies were used to produce a more precise estimate of the prognostic significance expression of cerbB-2.


RESULTS
The mean of cerbB-2 positive expression was 50% (95% confidence interval 48%-54%), cerbB-2 positive expression was related with node metastasis, recurrence after surgery and survival time; the RR values were 1.71, 2.14 and 2.32 respectively; tumor size, nuclear grade and pathology type were also the important factors that were related with the expression of cerbB-2, while the expression was not related with age; cerbB-2 was a special and sensitive prognostic factor for breast cancer.


CONCLUSIONS
cerbB-2 can be used as an independent molecular marker for definitive prognosis of breast cancer, as well as a reliable marker for choice of standard and individual therapy.
Du
Chang-zheng
CZ
Department of Oncology Chemotherapy, Peking University Third Hospital, Beijing 100083, China.
Li
Hui-ping
HP
Hou
Kuan-yong
KY
Li
Qiang
Q
Zhao
Hong-mei
HM
Wang
Mo-pei
MP
D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D009154:Mutation; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism
D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human