High diversity of HIV type 1 in Algeria.
We have sequenced different genes of HIV-1 strains from infected individuals recruited in various geographic parts of Algeria; phylogenetic trees were constructed yielding molecular characterization of these strains. Subtype B accounts for 56% of the samples studied and is therefore the predominant subtype, particularly in the north part of the country; but there is a high diversity of the virus including CRF02_AG, CRF06_cpx, CRF02/CRF06 interrecombinants, and different other intersubtype and/or inter-CRF recombinants. The prevalence of these non-B viruses increases in the south part of Algeria that borders sub-Saharan African countries. The high diversity of HIV-1 in Algeria has implications for virological follow-up, resistance surveys, and vaccine design.
Bouzeghoub
Salima
S
Laboratoire National de Référence VIH/SIDA, Institut Pasteur d?Algérie, Alger, Algérie.
Jauvin
Valérie
V
Recordon-Pinson
Patricia
P
Garrigue
Isabelle
I
Amrane
Achour
A
Belabbes
El-Hadj
el-H
Fleury
Hervé J
HJ
D000293:Adolescent; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005814:Genes, Viral; D014644:Genetic Variation; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D017423:Sequence Analysis, RNA; D013045:Species Specificity; D019562:Viral Load / Q000706:statistics & numerical data
D012367:RNA, Viral; D054303:HIV Reverse Transcriptase; D016333:HIV Protease