title: Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents.
abstract: [reaction: see text] A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO(2)Me) gave excellent yields (89%).
authors.affiliation: ACADIA Pharmaceuticals AB, Medeon Science Park S-20512, Malmö, Sweden.
authors.forename: Lars K
authors.initials: LK
authors.lastname: Ottesen
authors.forename: Fredrik
authors.initials: F
authors.lastname: Ek
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson
mesh_terms: D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D002712:Chlorides; D007202:Indicators and Reagents; D007501:Iron