Relation between charge-based apolipoprotein B-containing lipoprotein subfractions and remnant-like particle cholesterol levels.
OBJECTIVE
Both mildly modified LDL subfraction that carries a more-negative electric charge and remnant-like particles (RLP) are closely related to triglyceride (TG) levels. We examined the relation between the RLP-cholesterol (C) level and charge-based apolipoprotein (apo) B-containing lipoprotein subfractions as determined by capillary isotachophoresis (cITP) in patients with hypercholesterolemia.


RESULTS
cITP apo B lipoprotein subfractions were identified by analyzing plasma depleted of the related lipoproteins. While fast-migrating triglyceride-rich lipoprotein (fTRL) subfraction contained both chylomicrons and VLDL fraction, slow TRL (sTRL) only contained VLDL. cITP fLDL also contained VLDL fraction, i.e., beta-VLDL. Levels of cITP fTRL and sTRL were significantly correlated with serum levels of TG, RLP-C, apo C-II, and C-III. Levels of cITP sTRL were also correlated with apo E. Levels of cITP fLDL were positively correlated with not only LDL-C levels but also levels of TG, RLP-C, apo C-II, C-III, and E.


CONCLUSIONS
cITP fast LDL correlated with RLP-C levels and modified the relation between RLP-C and TG levels.
Zhang
Bo
B
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Böttcher
Alfred
A
Imaizumi
Satoshi
S
Noda
Keita
K
Schmitz
Gerd
G
Saku
Keijiro
K
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D004586:Electrophoresis; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood*
D001055:Apolipoproteins B; D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol