title: Functioning methionine-S-sulfoxide reductases A and B are present in human skin.
abstract: Methionine residues in the structure of proteins and peptides are especially sensitive to oxidation by hydrogen peroxide (H(2)O(2)) yielding both the (R) and (S) diastereomers of methionine sulfoxide. This commentary shows that both diastereomers of methionine sulfoxide (R and S) can be repaired in the human epidermis by methionine sulfoxide reductases A and B, respectively.
authors.affiliation: Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK. k.schallreuter@bradford.ac.uk
authors.forename: Karin U
authors.initials: KU
authors.lastname: Schallreuter
mesh_terms: D003545:Cysteine / Q000378:metabolism; D004220:Disulfides / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008715:Methionine / Q000378:metabolism; D051150:Methionine Sulfoxide Reductases; D008840:Microfilament Proteins; D010088:Oxidoreductases / Q000032:analysis / Q000502:physiology*; D017382:Reactive Oxygen Species; D012867:Skin / Q000201:enzymology*; D015595:Skin Aging; D013237:Stereoisomerism; D014157:Transcription Factors; D014364:Tryptophan / Q000378:metabolism
chemical_list: D004220:Disulfides; D008840:Microfilament Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D014364:Tryptophan; D008715:Methionine; D010088:Oxidoreductases; C120376:MSRB2 protein, human; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D003545:Cysteine