title: Stereoselective nucleophilic monofluoromethylation of N-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone.
abstract: [reaction: see text] Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford alpha-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to alpha-monofluoromethylated cyclic secondary amines with high stereoselectivity.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.forename: Chuanfa
authors.initials: C
authors.lastname: Ni
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Laijun
authors.initials: L
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Zheng
authors.forename: Lingui
authors.initials: L
authors.lastname: Zhu
authors.forename: Jinbo
authors.initials: J
authors.lastname: Hu