Traditional Morita-Baylis-Hillman reaction of aldehydes with methyl vinyl ketone co-catalyzed by triphenylphosphine and nitrophenol.
In the Morita-Baylis-Hillman reaction of aldehydes with methyl vinyl ketone (MVK), we found that in the presence of a catalytic amount of phenol, the Lewis base triphenylphosphine can effectively promote the reaction to give the corresponding normal Morita-Baylis-Hillman adducts in good yields. The mechanism has been investigated by 31P NMR spectroscopy. The solvent and substituent effects were also examined.
Shi
Min
M
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China. mshi@pub.sioc.ac.cn
Liu
Ying-Hao
YH