title: [The role of aspirin in the primary prevention of cardiovascular disease].
abstract: For persons without cardiovascular disease, the benefit of aspirin in primary prevention has been controversial until the recent publication of several major randomized controlled trials. Since then, several medical societies recommend that clinicians discuss aspirin prevention with adults at high cardiovascular risk. Patients with low cardiovascular risk are unlikely to benefit from aspirin, as potential harms (hemorrhagic strokes, gastrointestinal bleedings) may outweigh benefits. Aspirin should be recommended in primary prevention only in patients with a 10-year cardiovascular risk > or = 10% or in diabetic patients aged > or = 40 years with a concomitant cardiovascular risk factor, after assessing contraindications for aspirin and individual's preferences for the risks and benefits associated with aspirin.
authors.affiliation: Prévention cardiovasculaire Policlinique médicale universitaire et Institut universitaire de médecine sociale et preventive Département de médecine et de santé communautaire Université de Lausanne. Nicolas.Rodondi@hospvd.ch
authors.forename: N
authors.initials: N
authors.lastname: Rodondi
authors.forename: J
authors.initials: J
authors.lastname: Cornuz
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011322:Primary Prevention
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin