Systemic toxicity following ingestion of the chlorhexidine gluconate solution: a case report.
The purpose of this article is to discuss possible adverse effects and emergency treatments following the ingestion of chlorhexidine (CHX). In this case a dental student (age 25, male) accidentally swallowed one shot of 20% CHX solution, which is equal to 100 shots of the standard 0.2% CHX mouthwash. Clinical emergency treatment included: washing the oral cavity with 30 g of toothpaste, drinking 100 ml of 5% (w/v) alginate syrup and ingestion of 5 g of cork. The following adverse effects were experienced: headache, euphoria, giddiness, blurred vision (duration = 12 h), stomachache, gastric lavage with demulcents (duration = 24 h) and complete loss of taste sensation (duration = 8 h), which recurred during the next 48 h. No change in plasma aminotransferase level was seen. We used basic chemical information about the incompatibilities of CHX for clinical management of unintentional ingestion. It is known that CHX is a cation, and, therefore, first aid in case of intoxication with CHX involves using anionic materials.
Kolahi
Jafar
J
Odopharma Research Nucleus, Isfahan Science and Technology Town, Iran. kolahi@dnt.mui.ac.ir
Ghalayani
Parichehr
P
Varshosaz
Jaleh
J
D000328:Adult; D000464:Alginates / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000506:poisoning*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000506:poisoning; D003902:Detergents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000506:poisoning*; D032102:Phellodendron; D008517:Phytotherapy; D012967:Sodium Dodecyl Sulfate / Q000627:therapeutic use
D000464:Alginates; D000891:Anti-Infective Agents, Local; D003902:Detergents; D009067:Mouthwashes; D012967:Sodium Dodecyl Sulfate; C010882:chlorhexidine gluconate; D002710:Chlorhexidine