title: Late effects risk profiles using the long-term follow-up guidelines in identical twin survivors of acute lymphoblastic leukemia.
abstract: As the number of pediatric cancer survivors increases, the cost of cure (i.e., late effects) needs to be measured through a consistent mechanism. Through the use of the Children's Oncology Group's (COG) Long-Term Follow-Up (LTFU) guidelines, individualized risk profiles can be discerned for each off-therapy patient. These guidelines were used to compare and contrast risk profiles for identical twin females treated for acute lymphoblastic leukemia (ALL). The first twin was treated for high-risk leukemia and the second for standard-risk leukemia, each with different ALL protocols. Timely use of the LTFU guidelines has aided in identifying and treating their adverse late effects.
authors.affiliation: Department of Pediatrics, Emory University, Aflac Cancer and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, Georgia 30322, USA. dlhowell1998@msn.com
authors.forename: Della L
authors.initials: DL
authors.lastname: Howell
authors.forename: Glen
authors.initials: G
authors.lastname: Lew
authors.forename: Laura G
authors.initials: LG
authors.lastname: Comeaux
authors.forename: Lillian R
authors.initials: LR
authors.lastname: Meacham
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects*; D004200:Diseases in Twins / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017410:Practice Guidelines as Topic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000628:therapy*; D018570:Risk Assessment; D017741:Survivors; D014430:Twins, Monozygotic