title: [Analysis of auditory steady-state response to multiple simultaneous stimuli and cochlea morphology in guinea pigs with posterior semicircular canal fistula].
abstract: OBJECTIVE
  To observe the changes of auditory steady-state response (ASSR) threshold in guinea pigs with posterior semicircular canal fistula.
  
  
  METHODS
  In 10 guinea pigs, a window was opened in the posterior semicircular canal of the left ear with the right ear serving as the control for testing the ASSR under anesthesia with pentobarbital sodium.
  
  
  RESULTS
  The mean and standard deviation of ASSR threshold (dB SPL) at 0.5, 1, 2, and 4 kHz in the left ear was 35.00+/-14.33, 25.50+/-12.37, 20.00+/-9.37 and 20.00+/-9.18, respectively, and was 31.00+/-16.19, 25.50+/-12.34, 18.00+/-6.96 and 18.50+/-6.71 in the right ear, respectively. Paired-sample t test showed no significant difference in the ASSR at the same frequency between the two ears.
  
  
  CONCLUSIONS
  Small fistula by surgery causes no significant hearing loss in guinea pigs.
authors.affiliation: Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xienp@fimmu.com
authors.forename: Nan-ping
authors.initials: NP
authors.lastname: Xie
authors.forename: Guo-qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Xing
authors.initials: X
authors.lastname: Yang
authors.forename: Si-yun
authors.initials: SY
authors.lastname: Shu
mesh_terms: D000818:Animals; D001301:Audiometry, Pure-Tone / Q000379:methods; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000473:pathology*; D005072:Evoked Potentials, Auditory; D005402:Fistula / Q000473:pathology / Q000503:physiopathology*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000473:pathology / Q000503:physiopathology*; D012665:Semicircular Canals