Spontaneous absolute asymmetric synthesis in the presence of achiral silica gel in conjunction with asymmetric autocatalysis.
An enantiomerically enriched pyrimidyl alkanol with either S or R configurations was obtained stochastically from the reaction between pyrimidine-5-carbaldehyde and diisopropylzinc in the presence of achiral silica gel in conjunction with asymmetric autocatalysis with amplification of chirality.
Kawasaki
Tsuneomi
T
Department of Applied Chemistry, Tokyo University of Science, Tokyo, Japan. soai@rs.kagu.tus.jp
Suzuki
Kenta
K
Shimizu
Masako
M
Ishikawa
Keisuke
K
Soai
Kenso
K
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification; D002384:Catalysis; D005615:Freezing; D015394:Molecular Structure; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D058428:Silica Gel; D012822:Silicon Dioxide