Mild and direct conversion of quinoline N-oxides to 2-amidoquinolines with primary amides.
[reaction: see text] A simple, one-pot procedure is described for the direct conversion of quinoline N-oxides to alpha-amidoquinolines with primary amides. This methodology is complimentary to the Abramovich reaction, which is limited to the introduction of secondary amides via imidoyl chlorides. Although reaction conditions are quite similar, omission of the base is key for successful reaction with primary amides, which were found not to proceed through the intermediacy of an imidoyl chloride but rather through an acyl isocyanate.
Couturier
Michel
M
Chemical Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013, USA. michel.a.couturier@pfizer.com
Caron
Laurence
L
Tumidajski
Stephanie
S
Jones
Kris
K
White
Timothy D
TD