Antimutagenic activity of Sesbania javanica Miq. flower DMSO extract and its major flavonoid glycoside.
The antimutagenic activity of Sesbania javanica Miq. or Sano, an edible vegetable flower DMSO extract against aflatoxin B1 (AFB1) benzo (a) pyrene [B(a)P], was evaluated by means of the Ames' test. The Sesbania javanica Miq. flower DMSO extract showed a strong inhibitory effect against AFB1 and B(a)P mutagens. A search to isolate the major flavonoid in Sesbania javanica Miq. flower extract found the flavonol glycoside, Quercetin 3-2(G)-rhamnosylrutinoside, which was confirmed by its physicochemical properties as a major constituent of the flower. Quercetin 3-2(G)-rhamnosylrutinoside (207 microg/plate) also showeda strong inhibitory effect against AFB1 and B(a)P with a more than 70% inhibition rate.
Tangvarasittichai
Surapon
S
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. surapon14t@yahoo.com
Sriprang
Nimit
N
Harnroongroj
Talabporn
T
Changbumrung
Supranee
S
D016604:Aflatoxin B1; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D005419:Flavonoids / Q000494:pharmacology*; D035264:Flowers; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D049931:Sesbania
D016587:Antimutagenic Agents; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; D016604:Aflatoxin B1; D004121:Dimethyl Sulfoxide