title: An efficient enantioselective approach to cyclic beta-amino acid derivatives via olefin metathesis reactions.
abstract: The asymmetric synthesis of polyfunctionalized piperidine- and pyrrolidine-based scaffolds, specifically designed for the preparation of cyclic, conformationally constrained beta-amino acids, is realized combining a biocatalytic access to a versatile chiral building block with a wide range of transformations based on olefin metathesis.
authors.affiliation: Dipartimento di Chimica Organica e Industriale e Centro Interdisciplinare Studi biomolecolari e applicazioni Industriali, Università degli Studi di Milano, via G. Venezian 21, 20133 Milano, Italy.
authors.forename: Giordano
authors.initials: G
authors.lastname: Lesma
authors.forename: Bruno
authors.initials: B
authors.lastname: Danieli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sacchetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Silvani
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000598:Amino Acids, Cyclic