[Adrenal effect of inhaled corticosteroids in adult asthmatic patients].
Inhaled corticosteroids (ICS) are usually well tolerated with smaller systemic effects than intravenous steroids, however, when the dose is high the likelihood of steroid-related systemic side effects like hypothalamic pituitary adrenal (HPA) axis suppression and osteoporosis are reported. We reviewed HPA axis suppression related to different ICS characteristics by affinity to steroid receptor and their pharmacokinetics, and also reviewed by randomized, controlled clinical trials. Within the approved dosages for each ICS in Japan, HPA axis suppression is basically minimal and clinically negligible.
Adachi
Mitsuru
M
First Department of Internal Medicine, Showa University School of Medicine.
Minoguchi
Kenji
K
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D018592:Cross-Over Studies; D003907:Dexamethasone / Q000494:pharmacology; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D019983:Guideline Adherence; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic
D000305:Adrenal Cortex Hormones; D004304:Dosage Forms; D003907:Dexamethasone