Icilin evokes a dose- and time-dependent increase in glutamate within the dorsal striatum of rats.
Icilin, the peripheral cold channel agonist, activates TRPM8 and TRPA1, localized on dorsal root ganglia and trigeminal neurons in rats. Icilin precipitates immediate wet-dog shakes in this species, which are antagonized by centrally acting mu and kappa opioid agonists, implicating the central nervous system in the behavioral response. We studied the effect icilin has on glutamate levels in the dorsal striatum, a brain region involved in movement. Icilin (0.25, 0.5 and 0.75 mg/kg, i.p.) elicited a dose- and time-dependent increase in glutamate within the striatum, indicative of icilin's neurochemical effect in rats.
Werkheiser
J L
JL
Department of Pharmacology, Temple University Health Sciences Center, Philadelphia, PA19140, USA. jennifer.werkheiser@temple.edu
Rawls
S M
SM
Cowan
A
A
D000818:Animals; D017487:Ankyrins; D001522:Behavior, Animal / Q000187:drug effects; D015220:Calcium Channels / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005727:Ganglia, Spinal / Q000378:metabolism*; D018698:Glutamic Acid / Q000096:biosynthesis*; D008297:Male; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D050053:TRPM Cation Channels / Q000819:agonists / Q000378:metabolism; D013997:Time Factors
D017487:Ankyrins; D015220:Calcium Channels; D011744:Pyrimidinones; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D050053:TRPM Cation Channels; C480976:Trpa1 protein, rat; C498947:Trpm8 protein, rat; D018698:Glutamic Acid; C490483:icilin