The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature review.
OBJECTIVE
To review the literature estimating the cross-sectional prevalence of clinical depression in adults with Type 1 diabetes.


METHODS
Electronic databases and published references were used to identify studies published between January 2000 and June 2004, with a previous meta-analysis used to identify studies before 1 January 2000.


RESULTS
Between January 2000 and June 2004, a further five eligible studies were identified. Only one was a controlled study using diagnostic interviewing to determine rates of depression. Taking all of the eligible studies identified by the previous meta-analysis and this search, the prevalence of clinical depression in controlled studies was 12.0% for people with diabetes compared with 3.2% for control subjects. In studies with no control group, the prevalence of clinical depression was 13.4%.


CONCLUSIONS
There are wide-ranging differences reported in the various studies on the prevalence of depression in Type 1 diabetes. In view of the differing methods of diagnosis and small participant numbers, the results should be viewed with caution. A controlled study using diagnostic interviewing techniques to determine levels of depression is recommended to provide a clearer picture of both the prevalence and characteristics of that depression.
Barnard
K D
KD
University of Southampton, UK.
Skinner
T C
TC
Peveler
R
R
D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000150:complications / Q000453:epidemiology*; D003922:Diabetes Mellitus, Type 1 / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D015995:Prevalence