title: Helicobacter pylori infection is the major risk factor for gastric inflammation in the cardia.
abstract: We attempted to clarify the pathogenesis of gastric inflammation in the cardia. Eighty Japanese participated in this study. Biopsy specimens of the gastric antrum, corpus, and cardia (1 cm from the squamocolumnar junction) were obtained, and histological gastritis was evaluated. Cardiac inflammation was also evaluated using magnifying gastroscopy. We examined Helicobacter pylori infection, gastric juice pH/bile acid (BA), serum pepsinogen and gastrin levels, gastroesophageal reflux disease (GERD), and habitual smoking and assessed the relations between these factors and cardiac inflammation. The prevalence of H. pylori infection was statistically higher in patients with cardiac inflammation than in those without inflammation (P < 0.05). The relationship was also demonstrated by magnifying gastroscopy. Cardiac inflammation was linked to low acid output but not linked to the BA concentration or habitual smoking. Cardiac inflammation was more pronounced in patients without GERD. These results suggest that H. pylori is a major risk factor for cardiac inflammation in the Japanese.
authors.affiliation: Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Egi
authors.forename: Sunjin
authors.initials: S
authors.lastname: Kim
authors.forename: Masanori
authors.initials: M
authors.lastname: Ito
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yoshihara
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002299:Cardia / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005744:Gastric Acid / Q000502:physiology; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D005773:Gastroscopy / Q000379:methods; D016481:Helicobacter Infections / Q000382:microbiology* / Q000503:physiopathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D012307:Risk Factors
chemical_list: D005755:Gastrins; D020116:Pepsinogen A