Evaluation of combined nedaplatin and docetaxel therapy for human head and neck cancer in vivo.
BACKGROUND
Nedaplatin (NDP) was developed as a second-generation platinum complex. The antitumor efficacy of the combination of NDP with docetaxel (TXT) was evaluated against human head and neck carcinoma. The antitumor activity of NDP plus TXT was compared with that of some other platinum compounds, cisplatin (CDDP) and carboplatin (CBDCA) plus TXT.


METHODS
Mice implanted with HNC-3 or KB3-1, human head and neck carcinoma were administered i.v. NDP, CDDP or CBDCA plus TXT.


RESULTS
The antitumor efficacy was enhanced significantly by the combination of NDP with TXT. Combined NDP plus TXT treatment exerted antitumor efficacy comparable to that of combined CDDP plus TXT treatment. Thrombocytopenia induced by NDP was not enhanced by the combination of NDP and TXT.


CONCLUSIONS
The results suggest that combined NDP and TXT can alleviate thrombocytopenia caused by NDP and that this combination may have significant potential in clinical use.
Yamada
Hajime
H
Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukusima-Ku, Osaka, Japan.
Maki
Hideo
H
Takeda
Yukihiro
Y
Orita
Satoshi
S
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000494:pharmacology*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000077143:Docetaxel; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin; D016190:Carboplatin; D002945:Cisplatin