title: New polyethyleneglycol-functionalized texaphyrins: synthesis and in vitro biological studies.
abstract: The synthesis of four new analogues of motexafin gadolinium (MGd), a gadolinium(III) texaphyrin complex in clinical trials for its anticancer properties, is described. These new derivatives contain either 1,2-diaminobenzene or 2,3-diaminonaphthalene subunits as the source of the imine nitrogens and bear multiple 2-[2-(2-methoxyethoxy)ethoxy]ethoxy (PEG) groups, on either meso aryl or beta-pyrrolic substituents, to increase their water solubility. All four analogues were found to be more active in vitro than the parent system MGd as judged from cell proliferation assays using the PC3 and A549 cell lines.
authors.affiliation: Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, 1 University Station-A5300, The University of Texas at Austin, Austin, TX 78712-0165, USA.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Wei
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Mizuno
authors.forename: Cecilia
authors.initials: C
authors.lastname: Cortez
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Mint
authors.initials: M
authors.lastname: Sirisawad
authors.forename: Louie
authors.initials: L
authors.lastname: Naumovski
authors.forename: Darren
authors.initials: D
authors.lastname: Magda
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004563:Electrochemistry; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; C442892:texaphyrin