Cellular localization of NGF and its receptors trkA and p75LNGFR in male reproductive organs of the Japanese monkey, Macaca fuscata fuscata.
The actions of neurotropins are not restricted to the nervous system. Immunohistochemical methods were used in the present study to clarify distribution of nerve growth factor (NGF) and its receptors TrkA and p75LNGFR in excurrent ducts of the adult male Japanese monkey (Macaca fuscata fuscata). NGF was found in the seminal vesicle, epididymis, and testis, and has been thought to affect male reproductive functions. Leydig cells, Sertoli cells, and spermatogonia at various stages were positively stained for NGF, as well as for TrkA and p75LNGFR. Signals for these proteins were also found in epithelial cells and stromal tissues of the caudal epididymidis, as well as in the seminal vesicle. In the prostate, smooth muscle cells and basal cells were positively stained for NGF, TrkA, and p75 LNGFR. The results were comparatively discussed.
Jin
Wanzhu
W
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan.
Arai
Koji Y
KY
Shimizu
Keiko
K
Kojima
Chihiro
C
Itoh
Mariko
M
Watanabe
Gen
G
Taya
Kazuyoshi
K
D000818:Animals; D004822:Epididymis / Q000737:chemistry / Q000166:cytology; D005837:Genitalia, Male / Q000737:chemistry* / Q000166:cytology; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000737:chemistry; D008251:Macaca / Q000502:physiology*; D008297:Male; D020932:Nerve Growth Factor / Q000032:analysis*; D011467:Prostate / Q000737:chemistry / Q000166:cytology; D020800:Receptor, Nerve Growth Factor / Q000032:analysis*; D020917:Receptor, trkA / Q000032:analysis*; D012669:Seminal Vesicles / Q000737:chemistry / Q000166:cytology; D012708:Sertoli Cells / Q000737:chemistry; D013093:Spermatogonia / Q000737:chemistry; D013737:Testis / Q000737:chemistry / Q000166:cytology
D020800:Receptor, Nerve Growth Factor; D020932:Nerve Growth Factor; D020917:Receptor, trkA