[Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period].
OBJECTIVE
To investigate the protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period.


METHODS
Thirty-four patients with hypertension underwent general anesthesia were randomly divided into the control group and the puerarin group, 500mg puerarin was given to the puerarin group 1hr before anesthesia induction by venoclysis and to the control group, normal saline was given instead. The concentration of serum cardiac troponin I (cTnI) and isoenzyme of creatine kinase containing M and B subunits (CK-MB) were measured before anesthesia induction and 2 hrs after operation respectively.


RESULTS
The serum concentration of cTnI and CK-MB were insignificantly different in the two groups before induction, the two indexes increased in different degrees (P <0.01) 2 hrs after operation in both groups, but the increments in the puerarin group were significantly lower than those in the control group (P< 0.01).


CONCLUSIONS
Stress of operation and anesthesia could induce myocardial injury in patients with hypertension, which can be prevented by puerarin medicated during perioperational period.
Wu
Xian-Ping
XP
Hospital of Integrated Traditional and Western Medicine of Foshan City, Guangdong 4 528333. Wupeer@163.com
Feng
Jun-Guang
JG
Chen
Hao-Ming
HM
Cheng
Fang
F
Zhang
Lipei
L
Wei
Zhijun
Z
Chen
Weicai
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000601:surgery; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D019990:Perioperative Care; D008517:Phytotherapy; D019210:Troponin I / Q000097:blood
D007529:Isoflavones; D019210:Troponin I; D052279:Creatine Kinase, MB Form; C033607:puerarin