title: Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones.
abstract: Synthesis of flavones, 4-thioflavones and 4-iminoflavones was carried out with the substitution of variable halogens, methyl, methoxy and nitro groups in the A, B and AB rings of the respective compounds and we also report here their antibacterial activity. Most of the synthesized compounds were found to be active against Escherichia coli, Bacillus subtilis, Shigella flexnari, Salmonella aureus, Salmonella typhi and Pseudomonas aeruginosa. Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues. Investigated compounds having substituents like F, OMe and NO2 at 4'-position in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Ullah Mughal
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ayaz
authors.forename: Zakir
authors.initials: Z
authors.lastname: Hussain
authors.forename: Aurangzeb
authors.initials: A
authors.lastname: Hasan
authors.forename: Amina
authors.initials: A
authors.lastname: Sadiq
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Samreen
authors.initials: S
authors.lastname: Hussain
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D012763:Shigella flexneri / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D047309:Flavones