Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.
The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), 1beta-hydroperoxygermacra-4(15),5,10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds 1 approximately 4 and 8 showed non-specific significant cytotoxicity against five human tumor cell lines with ED50 values ranging from 0.36 approximately 5.54 microg/mL.
Choi
Sang Zin
SZ
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Yang
Min Cheol
MC
Choi
Sang Un
SU
Lee
Kang Ro
KR
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094062:Betulinic Acid
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D053978:Pentacyclic Triterpenes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; D014315:Triterpenes; C118308:betulonic acid; C000621518:zaluzanin C; D009828:Oleanolic Acid; D000094062:Betulinic Acid