RNA targeting using peptide nucleic acid.
The efforts towards peptide nucleic acid (PNA) drug discovery using cellular RNAs as molecular targets is briefly reviewed, with special emphasis on recent developments. Special attention is given to cellular delivery in vivo bioavailability and the possibilities of using PNA oligomers to (re)direct alternative splicing of pre-messenger (m)RNA.
Nielsen
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Department of Medical Biochemistry and Genetics, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, 2200 Copenhagen N, Denmark. pen@imbg.ku.dk
D000818:Animals; D001682:Biological Availability; D016503:Drug Delivery Systems; D006801:Humans; D020135:Peptide Nucleic Acids / Q000187:drug effects*; D012313:RNA / Q000187:drug effects* / Q000493:pharmacokinetics; D012328:RNA Viruses / Q000187:drug effects; D012333:RNA, Messenger / Q000187:drug effects
D020135:Peptide Nucleic Acids; D012333:RNA, Messenger; D012313:RNA