title: Crotalic and emarginellic acids: two triterpenes from Crotalaria emarginella and anti-inflammatory and anti-hepatotoxic activity of crotalic acid.
abstract: The aerial parts of Crotalaria emarginella Vatke (Leguminosae) has afforded two triterpenes, characterized as 3alpha-hydroxy-arbor-12-ene-28-carboxylic acid, designated as crotalic acid (1), and 2beta,3beta,21-trihydroxy-arbor-12-ene-29-carboxylic acid, designated as emarginellic acid (2). The structures of the isolated products were elucidated on the basis of spectral and chemical studies. On screening the biological activity, the crotalic acid (1) exhibited a significant anti-inflammatory activity (dose: 10mg/kg), which showed 53% inhibitory effect. Whereas, the standard oxyphenyl butazone (100mg/kg) exhibited 69% inhibition with respect to carrageenan (0.05ml, 1%) used to cause inflammation in rat paw method. In addition, it also showed anti-hepatotoxic activity by 13-30% with respect to standard silybon-70 (35-57%) against CCl(4) induced toxicity in Wistar rats.
authors.affiliation: Department of Pharmaceutical Chemistry, F/O Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India.
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
authors.forename: Tawfeq A
authors.initials: TA
authors.lastname: Al-Howiriny
authors.forename: Jaber S
authors.initials: JS
authors.lastname: Mossa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D029864:Crotalaria / Q000737:chemistry*; D004487:Edema / Q000188:drug therapy; D008107:Liver Diseases / Q000517:prevention & control*; D008968:Molecular Conformation; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D020011:Protective Agents; D014315:Triterpenes; C512943:crotalic acid; C512944:emarginellic acid; D002251:Carbon Tetrachloride