Tandem Nazarov cyclization-michael addition sequence catalyzed by an Ir(III) complex.
The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.
Janka
Mesfin
M
Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.
He
Wei
W
Haedicke
Inga E
IE
Fronczek
Frank R
FR
Frontier
Alison J
AJ
Eisenberg
Richard
R