Anesthetic efficacy of bupivacaine solutions in inferior alveolar nerve block.
The purpose of this study was to compare the anesthetic efficacy of 2 bupivacaine solutions. Twenty-two volunteers randomly received in a crossover, double-blinded manner 2 inferior alveolar nerve blocks with 1.8 mL of racemic bupivacaine and a mixture of 75% levobupivacaine and 25% dextrobupivacaine, both 0.5% and with 1 : 200,000 epinephrine. Before and after the injection, the first mandibular premolar was evaluated every 2 minutes until no response to the maximal output (80 reading) of the pulp tester and then again every 20 minutes. Data were analyzed using the Wilcoxon paired test and the paired t test. No differences were found between the solutions for onset and duration of pulpal anesthesia and duration of soft tissue anesthesia (P > .05). It was concluded that the solutions have similar anesthetic efficacy.
Volpato
Maria Cristina
MC
Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, São Paulo, Brazil. volpato@fop.unicamp.br
Ranali
José
J
Ramacciato
Juliana Cama
JC
de Oliveira
Patrícia Cristine
PC
Ambrosano
Glaúcia Maria Bovi
GM
Groppo
Francisco Carlos
FC
D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001641:Bicuspid / Q000294:innervation; D002045:Bupivacaine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D018592:Cross-Over Studies; D003782:Dental Pulp / Q000294:innervation; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007536:Isomerism; D000077554:Levobupivacaine; D008046:Lip / Q000294:innervation; D008297:Male; D008340:Mandibular Nerve / Q000187:drug effects; D008875:Middle Aged; D009407:Nerve Block; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D000077554:Levobupivacaine; D002045:Bupivacaine; D004837:Epinephrine