title: Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin.
abstract: A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins.
authors.affiliation: Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, 189 Guo-Shou-Jing Road, Shanghai 201203, China.
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Qiu
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Liu
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
authors.forename: Xing-Zu
authors.initials: XZ
authors.lastname: Zhu
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Nan
mesh_terms: D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D039821:Monoterpenes; D019920:Photoaffinity Labels / Q000737:chemistry*; D051381:Rats; D006027:Glycosides
chemical_list: D001565:Benzoates; D001710:Biotin; D001952:Bridged-Ring Compounds; D005960:Glucosides; D039821:Monoterpenes; D019920:Photoaffinity Labels; C015423:peoniflorin; D006027:Glycosides