title: A quest to understand molecular mechanisms for genetic stability.
abstract: In the midst of the post-war turmoil in Japan, I fortunately followed a path to become a scientist. Sometime at an early stage of my career, I encountered the problem of the cellular response to DNA damage and had the chance to discover a DNA repair enzyme. This event greatly influenced the subsequent course of my research, and I extended my studies toward elucidating the molecular mechanisms of mutagenesis as well as of carcinogenesis. Through these studies I came to understand the importance of mechanisms for dealing with the actions of reactive oxygen species to the living systems. These recollections deal with these endeavors with emphasis on the early part of my scientific career.
authors.affiliation: Frontier Research Center, Fukuoka Dental College, Tamura, Sawara-ku, Fukuoka 814-0006, Japan. mseki@college.fdcnet.ac.jp
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D005823:Genetics / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007564:Japan; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species