A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro.
A polysaccharide from the traditional Chinese medicinal herb, Bletilla striata (Thunb.) Reichb. f., was isolated, purified and characterized. It induced the proliferation of human umbilical vascular endothelial cells and the expression of vascular endothelial growth factor up to 156% and 147% of control after 72 h, respectively.
Wang
Chunming
C
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Sun
Jiantao
J
Luo
Yi
Y
Xue
Weihua
W
Diao
Huajia
H
Dong
Lei
L
Chen
Jiangning
J
Zhang
Junfeng
J
D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005690:Galactose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000032:analysis; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*; D014994:Xylose / Q000032:analysis
D011134:Polysaccharides; D042461:Vascular Endothelial Growth Factor A; D014994:Xylose; D005947:Glucose; D008358:Mannose; D005690:Galactose