The orphan nuclear receptors, estrogen receptor-related receptors: their role as new biomarkers in gynecological cancer.
The family of estrogen receptor-related receptors (ERRs) is a subfamily of the orphan nuclear receptors, which is closely related to the estrogen receptor (ER) family. Research on ERRs has shown that the ERR family share target genes, co-regulators and promoters with the ER family. ERRs seem to interfere with the classic ER-mediated estrogen responsive signaling in various ways. Moreover, ERRs have been reported to be prognostic biomarkers in breast, ovarian and colorectal cancer. ERRs should be considered as additional factors in the evaluation of gynecological tumors. Since ERRs have an important influence on the overall estrogenic response, they are of clinical importance in gynecological cancer, but also regarding women's general health.
Sun
Pengming
P
Department of Gynecology Oncology, Peking University People's Hospital, Peking University, Xizhimen South Street 11, 100044 Beijing, P R of China. sunfemy@hotmail.com
Wei
Lihui
L
Denkert
Carsten
C
Lichtenegger
Werner
W
Sehouli
Jalid
J
D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen