title: Comparison of spatial and temporal pattern for fMRI obtained with BOLD and arterial spin labeling.
abstract: Functional magnetic resonance imaging (fMRI) is presently either performed using blood oxygenation level-dependent (BOLD) contrast or using cerebral blood flow (CBF), measured with arterial spin labeling (ASL) technique. The present fMRI study aimed to provide practical hints to favour one method over the other. It involved three different acquisition methods during visual checkerboard stimulation on nine healthy subjects: 1) CBF contrast obtained from ASL, 2) BOLD contrast extracted from ASL and 3) BOLD contrast from Echo planar imaging. Previous findings were replicated; i) no differences between the three measurements were found in the location of the activated region; ii) differences were found in the temporal characteristics of the signals and iii) BOLD has significantly higher sensitivity than ASL perfusion. ASL fMRI was favoured when the investigation demands for perfusion and task related signal changes. BOLD fMRI is more suitable in conjunction with fast event related design.
authors.affiliation: Department of Psychiatric Neurophysiology, University Hospital of Clinical Psychiatry, Bern, Switzerland. federspiel@puk.unibe.ch
authors.forename: A
authors.initials: A
authors.lastname: Federspiel
authors.forename: T J
authors.initials: TJ
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Horn
authors.forename: C
authors.initials: C
authors.lastname: Kiefer
authors.forename: W K
authors.initials: WK
authors.lastname: Strik
mesh_terms: D001158:Arteries; D001769:Blood; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013113:Spin Labels
chemical_list: D013113:Spin Labels