Clinical features and surgical outcome of hepatic caudate lobe metastases from colorectal cancer.
BACKGROUND
The difficulty encountered in hepatectomy for the removal of a malignant tumor in the hepatic caudate lobe has recently been reported. However, few reports have described the clinical features of hepatic caudate lobe metastases from colorectal carcinoma.


METHODS
Retrospective clinicopathological data for 13 consecutive patients with colorectal metastases to the hepatic caudate lobe were analyzed for their various clinical aspects and long-term outcomes.


RESULTS
The tumor-free margin of the resected specimen was significantly smaller in the hepatic caudate lobe metastases group than in the other 178 patients with colorectal metastases in other sites of the liver (p<0.01), while the invasiveness of hepatectomy, as judged by the volume of liver resected and the duration of the procedure, was higher in the hepatic caudate lobe metastases group. Hepatic disease-free survival rates in the caudate lobe metastases group were lower than in the other group (p<0.01). By multivariate analysis, metastases to the hepatic caudate lobe negatively impacted hepatic disease-free survival (adjusted relative risk, 2.085; p=0.048).


CONCLUSIONS
In patients with hepatic caudate lobe metastases, hepatectomy with clear surgical margins is difficult, even when major hepatectomy is attempted. Hepatic metastasis in the caudate lobe is a risk factor for early liver recurrence after hepatectomy.
Tanaka
Kuniya
K
Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. ktrj112@urahp.yokohama-cu.ac.jp
Shimada
Hiroshi
H
Yamada
Michiyo
M
Shimizu
Tetsuya
T
Ueda
Michio
M
Matsuo
Kenichi
K
Nagano
Yasuhiko
Y
Togo
Shinji
S
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome