title: The hitchhiking effect of an autosomal meiotic drive gene.
abstract: Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genetic hitchhiking effect. We study this hitchhiking effect in the case of true meiotic drive in autosomes and show that it is more dependent on the recombination rate than in the classical case of a gene positively selected at the organism level.
authors.affiliation: UMR de Génétique Végétale du Moulon, INRA/Université Paris XI/CNRS/INA P-G, 91190 Gif-sur-Yvette, France. chevin@moulon.inra.fr
authors.forename: Luis-Miguel
authors.initials: LM
authors.lastname: Chevin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Hospital
mesh_terms: D000483:Alleles; D000818:Animals; D020090:Chromosome Segregation; D004331:Drosophila melanogaster / Q000235:genetics; D006579:Heterozygote; D040582:Inheritance Patterns; D008540:Meiosis; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic