title: [Effect of new qingkailing injection on cerebral edema following intracerebral hemorrhage in rats].
abstract: OBJECTIVE
  To investigate the effect of New Qingkailing injection (NQKLI) on cerebral edema following intracerebral hemorrhage (ICH) induced by collagenase VII in rats.
  
  
  METHODS
  After being established into ICH model by collagenase VII, rats were treated with NQKLI by intraperitoneal injection. Forty-eight hrs later, brain contents of water was detected with wet and dry method, calcium content in brain was detected by atomic spectrophotometer, tumor necrosis factor-alpha (TNF-alpha) in brain tissue was determined by liquid competitive ibhibitory immunoassay, and serum matrix metalloproteinase-9 (MMP-9) were detected with enzyme-linked immunosorbent assay (ELISA) respectively.
  
  
  RESULTS
  NQKLI reduced the contents of water, calcium and TNF-alpha content of brain tissue and serum MMP-9 in rats with ICH.
  
  
  CONCLUSIONS
  NQKLI could alleviate both vasogenic and cytotoxic cerebral edema by prohibiting calcium over-load, protecting basilar membrane and eliminating inflammation.
authors.affiliation: College of Basic Medicine, Beijing University of Traditional Chinese Medicine, Beijing (100029).
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Ming-Zhang
authors.initials: MZ
authors.lastname: Guo
authors.forename: Peng-Ying
authors.initials: PY
authors.lastname: Li
authors.forename: Hanrui
authors.initials: H
authors.lastname: Zhang
authors.forename: Lina
authors.initials: L
authors.lastname: Li
authors.forename: Pengtao
authors.initials: P
authors.lastname: Li
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000150:complications*; D017364:Collagenases; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D018696:Neuroprotective Agents / Q000008:administration & dosage; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha; D017364:Collagenases; D020780:Matrix Metalloproteinase 9