title: A prospective study of early-pregnancy plasma malondialdehyde concentration and risk of preeclampsia.
abstract: OBJECTIVE
  Preeclampsia is associated with elevated plasma malondialdehyde concentration, but prospective data are scarce. We examined the relation between early-pregnancy plasma malondialdehyde and subsequent preeclampsia risk.
  
  
  METHODS
  In a nested case-control analysis, we measured malondialdehyde concentrations in 22 women who developed preeclampsia and 711 who remained normotensive during pregnancy. We calculated adjusted odds ratios (OR) and 95% confidence intervals (CI). We repeated analyses after adjustment for early-pregnancy plasma lipid concentrations, which are related to preeclampsia risk and lipid peroxidation measures.
  
  
  RESULTS
  After adjustment for confounders, preeclampsia risk increased across tertiles of malondialdehyde concentration (trend P = 0.04). Further adjustment for triglyceride concentration slightly strengthened the association. Middle- and high-tertile malondialdehyde ORs were 3.2 (CI 0.8-12.2) and 4.2 (1.1-16.0) versus low-tertile exposure.
  
  
  CONCLUSIONS
  Early-pregnancy plasma malondialdehyde concentration is positively associated with subsequent preeclampsia risk independent of plasma lipid concentrations. These results support lipid peroxidation as an etiologic component of preeclampsia.
authors.affiliation: Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA. clb3@u.washington.edu
authors.forename: Carole B
authors.initials: CB
authors.lastname: Rudra
authors.forename: Chunfang
authors.initials: C
authors.lastname: Qiu
authors.forename: Robert M
authors.initials: RM
authors.lastname: David
authors.forename: J Alexander
authors.initials: JA
authors.lastname: Bralley
authors.forename: Scott W
authors.initials: SW
authors.lastname: Walsh
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D000328:Adult; D001835:Body Weight; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol