Microarray-based understanding of normal and malignant plasma cells.
Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.
De Vos
John
J
IRB, CHU Montpellier, Montpellier, France.
Hose
Dirk
D
Rème
Thierry
T
Tarte
Karin
K
Moreaux
Jérôme
J
Mahtouk
Karéne
K
Jourdan
Michel
M
Goldschmidt
Hartmut
H
Rossi
Jean-François
JF
Cremer
Friedrich W
FW
Klein
Bernard
B
D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010265:Paraproteinemias / Q000235:genetics*; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism