title: Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma?
abstract: BACKGROUND
  Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (K(trans)) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, K(trans), and overall survival.
  
  
  METHODS
  Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and K(trans) were calculated. The relationship of histologic grade, CBV, K(trans), age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered.
  
  
  RESULTS
  Both CBV (P < .01) and K(trans) (P < .01) show a significant relationship to histologic grade. CBV (P = .004), K(trans) (P = .008), and histologic grade (P < .001) all demonstrate a significant association with patient survival when analyzed individually. Cox regression analysis identified only histologic grade (P < .01) and K(trans) (P < .05) as independent significant prognostic indicators. Examination of survival data from high-grade (III and IV) tumors demonstrated a linear relationship between K(trans) and patient survival (P < .01).
  
  
  CONCLUSIONS
  This study suggests a direct relationship between K(trans) and length of survival in high-grade gliomas, which could be of clinical importance. CBV relates directly to histologic grade but provides no independent prognostic information over and above that provided by grade. Further large prospective studies should be planned to test whether this observation holds true.
authors.affiliation: Department of Imaging Science and Biomedical Engineering, Christie Hospital NHS Trust, Manchester, United Kingdom.
authors.forename: S J
authors.initials: SJ
authors.lastname: Mills
authors.forename: T A
authors.initials: TA
authors.lastname: Patankar
authors.forename: H A
authors.initials: HA
authors.lastname: Haroon
authors.forename: D
authors.initials: D
authors.lastname: Balériaux
authors.forename: R
authors.initials: R
authors.lastname: Swindell
authors.forename: A
authors.initials: A
authors.lastname: Jackson
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology*; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate
chemical_list: D003287:Contrast Media