title: Study of association between hypertensive disorders of pregnancy and the human coagulation factor XI gene.
abstract: OBJECTIVE
  Hypertensive disorders of pregnancy (HDP) are among the most common and serious complications of pregnancy. Persuasive evidence implicaties genetic factors in the genesis of HDP. The aim of the present study was to assess the association between single-nucleotide polymorphisms (SNPs) in the human coagulation factor XI (F11) gene and HDP, by conducting a haplotype-based case-control study.
  
  
  METHODS
  We chose 3 SNPs (rs925453, rs925451, and rs12500151) in the human F11 gene as genetic markers. We then conducted an association study with 77 HDP patients and 154 age-matched non-HDP subjects.
  
  
  RESULTS
  The frequency of rs925453 genotypes significantly differed between the two groups. The frequency of the T-G-G haplotype was significantly higher in the HDP group than in the non-HDP group (p = 0.0002).
  
  
  CONCLUSIONS
  The T allele of rs925453 and the T-G-G haplotype appear to be useful genetic markers of HDP.
authors.affiliation: Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sato
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Aya
authors.initials: A
authors.lastname: Maruyama
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Furuya
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mizutani
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005172:Factor XI / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
chemical_list: D005172:Factor XI