Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation.
BACKGROUND
WC and NS contributed equally. Non-tuberculous mycobacteria (NTM) frequently colonise patients with end stage cystic fibrosis (CF), but its impact on the course of the disease following lung transplantation is unknown.


METHODS
Lung transplant recipients with CF who underwent lung transplantation at our institution between January 1990 and May 2003 (n=146) and CF patients awaiting lung transplantation in May 2003 (n=31) were studied retrospectively.


RESULTS
The prevalence rate of NTM isolated from respiratory cultures in patients with end stage CF referred for lung transplantation was 19.7%, compared with a prevalence rate of 13.7% for NTM isolates in CF lung transplant recipients. The overall prevalence of invasive NTM disease after lung transplantation was low (3.4%) and was predicted most strongly by pre-transplant NTM isolation (p=0.001, Fisher's exact test, odds ratio (OR) 6.13, 95% CI 3.2 to 11.4). This association was restricted to Mycobacterium abscessus (p = 0.005, Fisher's exact test, OR 7.45, 95% CI 2.9 to 16.9). While NTM disease caused significant morbidity in a small number of patients after transplantation, it was successfully treated and did not influence the post-transplant course of the disease.


CONCLUSIONS
The isolation of NTM before transplantation in CF patients should not be an exclusion criterion for lung transplantation, but it may alert the clinician to patients at risk of recurrence following transplantation.
Chalermskulrat
W
W
Lung Transplantation Program and Cystic Fibrosis Research and Treatment Center, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, USA.
Sood
N
N
Neuringer
I P
IP
Hecker
T M
TM
Chang
L
L
Rivera
M P
MP
Paradowski
L J
LJ
Aris
R M
RM
D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000382:microbiology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology* / Q000503:physiopathology; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000382:microbiology* / Q000503:physiopathology