[Study on pharmacokinetics of PVP coated beta-elemene liposome in rats].
OBJECTIVE
To study the pharmacokinetics of PVP costed beta-elemente liposmes in rats.


METHODS
Gas chromatography was established to determine the concentration of beta-elemene in plasma of rats after administered through i.g.


RESULTS
The pharmacokinetics parameters was: T(1/2) = 95.07 +/- 20.46 min, AUC = 348.72 +/- 32.49 microg x min/ml, Cmax = 4.39 +/- 0.33 microg/ml, Tmax = 60 min.


CONCLUSIONS
The bioavailability of PVP coated beta-elemene liposomes is 140.2 +/- 7.5% compared with conventional liposomes.
Zhang
Xiu-yu
XY
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Deng
Ying-jie
YJ
Zhao
Chun-jie
CJ
Wang
Xiu-min
XM
Li
Zhe
Z
Gao
Xiao-fei
XF
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002849:Chromatography, Gas; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008081:Liposomes; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011760:Pyrrolidinones; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D008081:Liposomes; D011760:Pyrrolidinones; D012717:Sesquiterpenes; C445979:beta-elemene