title: PPAR-gamma: a thrifty transcription factor.
abstract: The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.
authors.affiliation: Institut de Genetique et Biologie Moleculaire et Cellulaire (IGBMC) and and Institut Clinique de la Souris (ICS), 67404 Illkirch, France. auwerx@igbmc.u-strasbg.fr
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
authors.forename: Terrie-Ann
authors.initials: TA
authors.lastname: Cock
authors.forename: Chris
authors.initials: C
authors.lastname: Knouff