NoCut: cytokinesis in check.
In this issue of Cell, Norden et al. (2006) describe a new pathway, NoCut, that links the completion of chromosome segregation to the onset of cytokinesis in budding yeast. In NoCut, Aurora kinase (Ipl1) at the spindle midzone negatively regulates cytokinesis through two proteins previously identified to be involved in cell polarity, Boi1 and Boi2.
Bloom
Kerry
K
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. kbloom@email.unc.edu
D064127:Aurora Kinases; D020090:Chromosome Segregation / Q000502:physiology*; D015825:Chromosomes, Fungal / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism
D029701:Saccharomyces cerevisiae Proteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases