First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies.
Bransteitter
Ronda
R
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
Sneeden
Jessica L
JL
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
Allen
Sariah
S
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
Pham
Phuong
P
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
Goodman
Myron F
MF
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910. Electronic address: mgoodman@usc.edu.
D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D003564:Cytidine Deaminase / Q000378:metabolism / Q000502:physiology*; D043525:Cytosine Deaminase / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System; D017578:Immunoglobulin Class Switching; D007132:Immunoglobulin Isotypes / Q000737:chemistry; D007136:Immunoglobulins / Q000737:chemistry; D008957:Models, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000906:Antibodies; D007132:Immunoglobulin Isotypes; D007136:Immunoglobulins; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D043525:Cytosine Deaminase; D003564:Cytidine Deaminase