Reactive oxygen species signaling in vascular smooth muscle cells.
Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.
Clempus
Roza E
RE
Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr. Atlanta, GA 30322, USA.
Griendling
Kathy K
KK
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000378:metabolism* / Q000473:pathology; D019255:NADPH Oxidases / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology
D010982:Platelet-Derived Growth Factor; D017382:Reactive Oxygen Species; D000804:Angiotensin II; D019255:NADPH Oxidases