Organ preconditioning: the past, current status, and related lung studies.
Preconditioning (PC) has emerged as a powerful method for experimentally and clinically attenuating various types of organ injuries. In this paper related clinical and basic research issues on organ preconditioning issues were systemically reviewed. Since lung injuries, including ischemia-reperfusion and others, play important roles in many clinical results, including thromboembolism, trauma, thermal injury, hypovolemic and endotoxin shock, reimplantation response after organ transplantation, and many respiratory diseases in critical care. It is of interest to uncover methods, including the PCs, to protect the lung from the above injuries. However, related studies on pulmonary PC are relatively rare and still being developed, so we will review previous literature on experimental and clinical studies on pulmonary PC in the following paragraphs.
Luh
Shi-ping
SP
Department of Cardiothoracic Surgery, Taipei Tzu-Chi Medical University Hospital, Taiwan 231, China. luh572001@yahoo.com.tw
Yang
Pan-chyr
PC
D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury; D016040:Lung Transplantation; D013997:Time Factors; D019172:Transplantation Conditioning