Cutaneous leukocytoclastic vasculitis in a child with interleukin-12 receptor beta-1 deficiency.
We report a patient with complete interleukin-12 receptor beta-1 deficiency associated with cutaneous leukocytoclastic vasculitis. The patient experienced Bacille Calmette Guérin, Mycobacterium chelonae, and Salmonella enteritidis infection. Vasculitis affecting both small arteries and postcapillary venules due to deposition of immune complexes was probably caused by S. enteritidis and/or M. chelonae infection.
Kutukculer
Necil
N
Department of Pediatrics, Ege University Medical School, Izmir, Turkey. neci@med.ege.edu.tr
Genel
Ferah
F
Aksu
Guzide
G
Karapinar
Bulent
B
Ozturk
Can
C
Cavusoglu
Cengiz
C
Casanova
Jean-Laurent
JL
Fieschi
Claire
C
D000818:Animals; D002417:Cattle; D002648:Child; D003241:Consanguinity; D005260:Female; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy; D009163:Mycobacterium bovis / Q000302:isolation & purification; D016926:Mycobacterium chelonae / Q000302:isolation & purification; D016659:Psoas Abscess / Q000382:microbiology; D018123:Receptors, Interleukin / Q000172:deficiency*; D053707:Receptors, Interleukin-12; D012480:Salmonella Infections / Q000175:diagnosis / Q000188:drug therapy; D012477:Salmonella enteritidis / Q000302:isolation & purification; D013163:Splenomegaly / Q000601:surgery; D014380:Tuberculosis, Bovine / Q000175:diagnosis / Q000188:drug therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000382:microbiology*
D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12