Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States).
OBJECTIVE
To examine the relationship between anthropometric measures and ovarian cancer by menopausal status.


METHODS
We analyzed data from a population-based case-control study comprised of 700 incident cases of epithelial ovarian cancer and 5,943 population controls from Massachusetts and Wisconsin enrolled between 1993 and 2001. In a telephone interview, information was gathered on established ovarian cancer risk factors, as well as adult height and age-specific body weight. Logistic regression was used to estimate multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for body mass index (BMI) throughout life.


RESULTS
Recent BMI had no significant association with ovarian cancer risk (P-trend 0.14 for continuous BMI), after adjustment for age and other ovarian cancer risk factors. However, a non-significant positive association (overall P-trend 0.08) was observed for BMI at age 20; the risk estimate comparing a body mass of >25 kg/m2 to the lowest quintile (<or=18.88 kg/m2) was moderately but non-significantly elevated (OR 1.46; 95% CI 0.92, 2.31).


CONCLUSIONS
Results of this study suggest that maintenance of a lean body mass, particularly in early adult life, may decrease ovarian cancer risk.
Peterson
Neeraja B
NB
Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232-8300, USA. neeraja.peterson@vanderbilt.edu
Trentham-Dietz
Amy
A
Newcomb
Polly A
PA
Chen
Zhi
Z
Gebretsadik
Tebeb
T
Hampton
John M
JM
Stampfer
Meir J
MJ
Willett
Walter C
WC
Egan
Kathleen M
KM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008404:Massachusetts; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000209:etiology*; D012307:Risk Factors; D014922:Wisconsin