A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
Fan
Xuesen
X
Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
Zhang
Xinying
X
Zhou
Longhu
L
Keith
Kathy A
KA
Kern
Earl R
ER
Torrence
Paul F
PF
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018155:Orthopoxvirus / Q000187:drug effects* / Q000502:physiology*; D047069:Pyrazolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014779:Virus Replication
D000998:Antiviral Agents; D009705:Nucleosides; D047069:Pyrazolones; D011743:Pyrimidines; C030986:pyrimidine