title: Thienopyridines in percutaneous coronary interventions: standard procedures and high risk subsets.
abstract: Due to the significant clinical and economic consequences of subacute stent thrombosis and the use of more complex devices (brachytherapy, drug eluting stents) in a variety of clinical situations (i.e. acute coronary syndromes), initiation and duration of a combined antiplatelet therapy using aspirin and a thienopyridine drug has become an issue of ongoing discussion in interventional cardiology. This review will provide a short introduction into the pathophysiology of stent thrombosis before standard procedures and critical issues on the use of thienopyridines in the setting of coronary interventions are discussed. Furthermore, clinically relevant issues that are not clearly covered by recommendations or guidelines like thienopyridines after coronary interventions in patients on chronic oral anticoagulation are also addressed.
authors.affiliation: Medical Clinic II, University of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. radke@innere2.uni-luebeck.de
authors.forename: Peter W
authors.initials: PW
authors.lastname: Radke
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Alma
authors.initials: A
authors.lastname: Zernecke
authors.forename: Axel
authors.initials: A
authors.lastname: Kaiser
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001672:Biocompatible Materials; D001918:Brachytherapy; D000077144:Clopidogrel; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D008670:Metals / Q000009:adverse effects; D010975:Platelet Aggregation Inhibitors / Q000191:economics / Q000627:therapeutic use*; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000517:prevention & control; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D008670:Metals; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine