title: Addressing the challenges of cellular delivery and bioavailability of peptide nucleic acids (PNA).
abstract: Recent results on the cellular delivery of antisense peptide nucleic acids (PNA) via peptide conjugation is briefly discussed, in particular in the context of endosomal entrapment and escape.
authors.affiliation: Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Blegdamsvej 3c, 2200 Copenhagen N, Denmark. pen@imbg.ku.dk
authors.forename: Peter E
authors.initials: PE
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D001682:Biological Availability; D055592:Biophysical Phenomena; D001703:Biophysics; D011992:Endosomes / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000493:pharmacokinetics; D020135:Peptide Nucleic Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D020319:Oligodeoxyribonucleotides, Antisense; D020135:Peptide Nucleic Acids