title: Antibacterial-coated tracheal tubes cleaned with the Mucus Shaver : a novel method to retain long-term bactericidal activity of coated tracheal tubes.
abstract: OBJECTIVE
  To assess the long-term benefit from antibacterial coatings of the tracheal tube (ETT), and to keep clean the lumen of the ETT.
  
  
  METHODS
  Experimental animal study.
  
  
  METHODS
  USA National Institutes of Health.
  
  
  METHODS
  Twelve sheep.
  
  
  METHODS
  Twelve ETTs were internally dip-coated with a silver-sulfadiazine in polyurethane. We developed a concentric inflatable silicone rubber "razor", the Mucus Shaver (MS), to shave the ETT lumen free of mucus. In a single pass, we cleaned all mucus from the internal surface of the ETT.
  
  
  METHODS
  Five intubated sheep were mechanically ventilated for 72 h. The ETT was suctioned every 6 h.
  
  
  METHODS
  Six sheep were intubated and mechanically ventilated for 72 h. The ETT was suctioned and cleaned with the MS every 6 h. An additional sheep was intubated and mechanically ventilated for 168 h. Bacteriologic studies and scanning electron microscopy were performed to assess bacterial colonization and thickness of secretions on the internal surface of the ETT.
  
  
  RESULTS
  In the control group, the ETT was always heavily colonized: median debris thickness was 380 microm, range 270-550 microm. In the study group, there was no colonization and no secretions in the ETT, except for three ETT that were colonized solely at the very tip.
  
  
  CONCLUSIONS
  Silver-based coating of ETT cleaned with the MS every 6 h significantly reduces accumulation of mucus/secretion and bacterial growth within the ETT following 72 h of mechanical ventilation.
authors.affiliation: Massachusetts General Hospital, Department of Anesthesia and Critical Care, Boston MA, USA. lberra@partners.org
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Berra
authors.forename: Francesco
authors.initials: F
authors.lastname: Curto
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Li Bassi
authors.forename: Patrice
authors.initials: P
authors.lastname: Laquerriere
authors.forename: Andrea
authors.initials: A
authors.lastname: Baccarelli
authors.forename: Theodor
authors.initials: T
authors.lastname: Kolobow
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D015169:Colony Count, Microbial; D004866:Equipment Contamination / Q000517:prevention & control*; D007442:Intubation, Intratracheal / Q000295:instrumentation*; D008396:Maryland; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology / Q000517:prevention & control*; D012756:Sheep; D012122:Ventilators, Mechanical
chemical_list: D000900:Anti-Bacterial Agents