Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals.
The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
Klos
K J
KJ
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Ahlskog
J E
JE
Josephs
K A
KA
Apaydin
H
H
Parisi
J E
JE
Boeve
B F
BF
DeLucia
M W
MW
Dickson
D W
DW
D000368:Aged; D001921:Brain / Q000473:pathology*; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D008499:Medical Records; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D051844:alpha-Synuclein / Q000032:analysis*
D051844:alpha-Synuclein