title: Massive cutaneous follicular lymphoid hyperplasia in a patient with the Sjögren syndrome: 7-year follow-up and immunohistochemical study.
abstract: The Sjögren syndrome often gives rise to complications such as pseudolymphomas and/or mucosa-/skin-associated lymphocytic tumors (MALT/SALT lymphomas). This paper presents a 74-year-old female patient with the Sjögren syndrome complicated by cutaneous plaques/tumors as cutaneous lymphoid hyperplasia over a 7-year follow-up study period. Immunohistochemical examination disclosed B-cell rich lymphoid follicle formation in the skin with the presence of T and B cells and a varied assortment of features to include abundant plasma cell infiltration. Based on the clinical course and histopathological findings, patient condition was considered benign and arises from reaction toward certain unknown microbes.
authors.affiliation: Department of Dermatology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501 Nagasaki, Japan. ngu-yashoriu@r7.dion.ne.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Horiuchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Hakugawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019310:Pseudolymphoma / Q000175:diagnosis* / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications*; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology