title: Molecular recognition: improved binding of biotin derivatives with synthetic receptors.
abstract: NMR titrations and Monte Carlo conformational searches have been used to study the molecular recognition features of five urea derivatives with two synthetic hosts. We have improved the binding constant (Kb) values for all the studied guests and measured the largest binding constant of a complex involving a biotin derivative (biotin methyl ester) bound to a synthetic host by means of several interaction points and not only through the urea moiety.
authors.affiliation: Departamento de Química Organica y Bio-Organica, UNED, Facultad de Ciencias, Senda del Rey 9, E-28040 Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Herranz
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Santa María
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Claramunt
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001710:Biotin / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D017978:Receptors, Growth Factor / Q000737:chemistry*
chemical_list: D017978:Receptors, Growth Factor; C052136:biotin receptor; D001710:Biotin