title: [Creatine as a metabolic controller of skeletal muscles structure and function in strength exercises in humans].
abstract: The aim of study was to investigate the effect of oral creatine supplementation upon muscle performance and aerobic capacity of the organism. Knee extensor muscles of two groups with 9 subjects in each were subjected to strength training with and without creatine supplementation (Cre and Pla) for 10 weeks, three times a week with an effort of up to 85% of maximal voluntary contraction (MVC). The Cre group received 5 g of creatine monohydrate a day. After 10 weeks strength training, an increase of MVC by 29 and 40% in training (isotonic) regimen was recorded for the Pla and Cre groups respectively. The muscle isokinetic torque increments of 10-11% were obtained in the Pla group at angular velocities corresponding to training velocities, and in the Cre group increments of 11-17% were recorded at all angular velocities tested. No changes were found in the fatigue test by the Pla group, whereas Cre group showed a tendency for an increase. The aerobic and anaerobic capacities of the organism did not decrease in both groups. Thus the creatine supplementation during strength training potentates an increase of force-velocity characteristics of trained muscle group without impeding aerobic capacity of the organism.
authors.forename: a I
authors.initials: aI
authors.lastname: Netreba
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: D V
authors.initials: DV
authors.lastname: Popov
authors.forename: O S
authors.initials: OS
authors.lastname: Tarasova
authors.forename: A B
authors.initials: AB
authors.lastname: Vdovina
authors.forename: V P
authors.initials: VP
authors.lastname: Khotchenkov
authors.forename: T N
authors.initials: TN
authors.lastname: Stekhanova
authors.forename: O L
authors.initials: OL
authors.lastname: Vinogradova
mesh_terms: D000328:Adult; D003401:Creatine / Q000008:administration & dosage* / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D018763:Muscle Fatigue / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology
chemical_list: D003401:Creatine