[Study on the development of DNA immunization technique].
As the third generation of vaccine, DNA immunization seems to be advantageous over classic immunization with purified proteins, which can induce complete immune responses against a number of infectious agents and can be used safely, economically and conveniently. The author reviews the new development of DNA immunization, including parameters affecting its effectiveness, the basic underlying biological mechanisms, and its application on generation of antibodies, infant immunization, mucous membrane immunization, and expression library immunization etc. In addition, we introduce some strategies of improving the effect of DNA immunization.
Yang
Li-Chen
LC
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Yang
Xiao-Guang
XG
D000818:Animals; D004247:DNA / Q000276:immunology*; D006801:Humans; D007114:Immunization; D009092:Mucous Membrane / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology*
D019444:Vaccines, DNA; D004247:DNA