title: Successful treatment of Helicobacter pylori-negative gastric MALT lymphoma with rituximab.
abstract: Helicobacter pylori infection is strongly associated with low-grade gastric lymphoma, commonly known as mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori eradication leads to complete remission in 80% of early stage MALT lymphomas. The treatment for early stage H. pylori-negative gastric MALT lymphoma is evolving. Rituximab, a chimeric anti-CD20 antibody, has shown response rates of approximately 50% with minimal toxicity in patients with B-cell non-Hodgkin lymphoma. We describe herein the clinical, endoscopic, and histologic features of a patient with H. pylori-negative gastric MALT lymphoma treated successfully with rituximab.
authors.affiliation: University of Oklahoma Health Sciences Center, Division of Gastroenterology, Department of Medicine, Oklahoma City, Oklahoma, USA.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Chaudhary
authors.forename: Howard
authors.initials: H
authors.lastname: Ozer
authors.forename: David
authors.initials: D
authors.lastname: Huard
authors.forename: Stan
authors.initials: S
authors.lastname: Lightfoot
authors.forename: Sikandar
authors.initials: S
authors.lastname: Mesiya
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D005773:Gastroscopy / Q000379:methods; D016481:Helicobacter Infections / Q000175:diagnosis; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D000069283:Rituximab; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab