Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder.
OBJECTIVE
NGF and PGs in the bladder can be affected by pathological changes in the bladder and these changes can be detected in urine. We investigated changes in urinary NGF and PGs in women with OAB.


METHODS
The study groups included 65 women with OAB and 20 without bladder symptoms who served as controls. Evaluation included patient history, urinalysis, a voiding diary and urodynamic studies. Urine samples were collected. NGF, PGE2, PGF2alpha and PGI2 were measured using enzyme-linked immunosorbent assay and compared between the groups. In addition, correlations between urinary NGF and PG, and urodynamic parameters in patients with OAB were examined.


RESULTS
Urinary NGF, PGE2 and PGF2alpha were significantly increased in patients with OAB compared with controls (p <0.05). However, urinary PGI2 was not different between controls and patients with OAB. In patients with OAB urinary PGE2 positively correlated with volume at first desire to void and maximum cystometric capacity (p <0.05). Urinary NGF, PGF2alpha and PGI2 did not correlate with urodynamic parameters in patients with OAB.


CONCLUSIONS
NGF and PGs have important roles in the development of OAB symptoms in female patients. Urinary levels of these factors may be used as markers to evaluate OAB symptoms.
Kim
Joon Chul
JC
Department of Urology, College of Medicine, Catholic University of Korea, Seoul, Korea. kjc@catholic.ac.kr
Park
Eun Young
EY
Seo
Seong Il
SI
Park
Yong Hyun
YH
Hwang
Tae-Kon
TK
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000652:urine*; D011453:Prostaglandins / Q000652:urine*; D014549:Urinary Incontinence / Q000652:urine*
D015415:Biomarkers; D011453:Prostaglandins; D020932:Nerve Growth Factor