title: Multifollicular ovaries in female adolescents with cystic fibrosis.
abstract: OBJECTIVE
  To assess hormonal status and morphology of ovaries in cystic fibrosis (CF) adolescents.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Female adolescents: 18 with CF and 18 normal.
  
  
  METHODS
  Transabdominal pelvic ultrasonography and venipuncture.
  
  
  METHODS
  Hormone profile and ultrasound examination of ovaries and uterus.
  
  
  RESULTS
  Levels of LH, LH/FSH, androstenedione, and PRL were significantly higher in the CF adolescents. Levels of sex hormone-binding globulin (SHBG) were significantly lower and had negative correlation with percentage of body fat. Percentage of body fat and body mass index were significantly lower in CF and had significant correlation. Levels of E2, FSH, T, and DHEAS were comparable in the two groups. Ultrasound revealed cysts in eight (44%) of the CF subjects; six of these had LH/FSH >3, and three had been operated for ovarian torsion. Nine out of all of the CF subjects (50%) had DM. No obesity, hirsutism, or acne was observed. The Shwachman score was 87.44 +/- 4.83 and correlated significantly with the percentage of body fat.
  
  
  CONCLUSIONS
  Multifollicular ovaries were frequent in CF adolescents. Hormone changes characteristic of polycystic ovary syndrome were detected. The low T levels, despite low SHBG, and the absence of hirsutism or acne may be a result of a lower percentage of body fat, disturbances at the pilosebaceous-adipocyte endocrine unit, or mechanical or other causes.
authors.affiliation: Fourth Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. galtsin@otenet.gr
authors.forename: Assimina
authors.initials: A
authors.lastname: Galli-Tsinopoulou
authors.forename: Tatiana
authors.initials: T
authors.lastname: Moudiou
authors.forename: Apostolos
authors.initials: A
authors.lastname: Mamopoulos
authors.forename: Michael
authors.initials: M
authors.lastname: Karamouzis
authors.forename: Sanda
authors.initials: S
authors.lastname: Nousia-Arvanitakis
mesh_terms: D050154:Adiposity; D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D012739:Gonadal Steroid Hormones; D006062:Gonadotropins