title: [Evaluation of efficacy and clinical impact of positron emission tomography with 18F fluoro-deoxyglucose (FDG) in patients with suspicion of recurrent laryngeal carcinoma].
abstract: OBJECTIVE
  To evaluate the efficacy and clinical impact of FDG-PET in patients with suspected recurrent laryngeal carcinoma.
  
  
  METHODS
  15 patients, with suspicion of recurrent laryngeal carcinoma and ambiguous conventional imaging modalities. In all patients a whole body scan was performed with FDG-PET in fasting patients following i.v. administration of 370-444 MBq FDG. The results were confirmed by histology and clinical evolution (follow-up period > 12 months).
  
  
  RESULTS
  Prevalence of recurrence was 86.6%. FDG-PET was positive in 13 patients, with confirmation in all cases, and 2 were true negative (TN). Overall sensitivity, specificity, PPV, NPV and accuracy were 100%. FDG-PET changed the modality of treatment in 10 patients (clinical impact 63.3%).
  
  
  CONCLUSIONS
  FDG-PET has high clinical impact in patients with a suspicion of recurrent laryngeal carcinoma, and should be incorporated to the diagnostic protocols before making a therapy decision.
authors.affiliation: Servicio de Medicina Nuclear, HHUU Virgen del Rocío Sevilla. rosalvarezp@hotmail.com
authors.forename: R M
authors.initials: RM
authors.lastname: Alvarez Pérez
authors.forename: I
authors.initials: I
authors.lastname: Borrego Dorado
authors.forename: R
authors.initials: R
authors.lastname: Vázquez Albertino
authors.forename: J
authors.initials: J
authors.lastname: Ruiz Franco-Baux
authors.forename: J M
authors.initials: JM
authors.lastname: Ceballo Pedraja
authors.forename: F
authors.initials: F
authors.lastname: Esteban Ortega
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18