title: Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
abstract: Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
authors.affiliation: Sunway University College, Bandar Sunway, 46150, P.J. Selangor, Malaysia.
authors.forename: Tan Siew
authors.initials: TS
authors.lastname: Kiat
authors.forename: Richard
authors.initials: R
authors.lastname: Pippen
authors.forename: Rohana
authors.initials: R
authors.lastname: Yusof
authors.forename: Halijah
authors.initials: H
authors.lastname: Ibrahim
authors.forename: Norzulaani
authors.initials: N
authors.lastname: Khalid
authors.forename: Noorsaadah Abd
authors.initials: NA
authors.lastname: Rahman
mesh_terms: D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D003510:Cyclohexanes / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000378:metabolism*; D030521:Zingiberaceae / Q000737:chemistry*; D000085242:Viral Proteases
chemical_list: D002599:Chalcone; D003510:Cyclohexanes; D005419:Flavonoids; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; C512303:cyclohexenyl chalcone; C504449:NS3 protease, dengue virus; D000085242:Viral Proteases