title: [Subthalamic deep brain stimulation for severe idiopathic Parkinson's disease. Location study of the effective contacts].
abstract: The subthalamic nucleus (STN) is the main target of deep brain stimulation (DBS) treatment for severe idiopathic Parkinson's disease. But there is still no clear information on the location of the effective contacts (used during the chronic phase of stimulation). Our aim was to assess the anatomical structures of the subthalamic area (STA) involved during chronic DBS. Ten patients successfully treated were included. The surgical procedure was based on direct STN targeting (stereotactic MRI based) pondered by the acute effects of intraoperative stimulation. We used a formaldehyde-fixed human specimen to compare by matching MRI images obtained at 1.5 Tesla (performed in clinical stereotactic conditions) and at very high field at 4.7 Tesla. This allowed accurate analysis of the anatomy of the STA and retrospective precision of the location of the center of effective contacts which were located within the STN in 4 patients, at the interface between the STN and the ZI and/or FF in 13, at the interface between ZI and FF in 2 and between the STN and the substantia nigra in one. These results were consistent with the literature, revealing the implication of neighboring structures, especially the zona incerta and Forel's Field, in the clinical benefit.
authors.affiliation: Service de Neurochirurgie A, Hôpital Gabriel-Montpied, CHU, BP 69, 63003 Clermont-Ferrand Cedex 1, France.
authors.forename: F
authors.initials: F
authors.lastname: Caire
authors.forename: Ph
authors.initials: P
authors.lastname: Derost
authors.forename: J
authors.initials: J
authors.lastname: Coste
authors.forename: J-M
authors.initials: JM
authors.lastname: Bonny
authors.forename: F
authors.initials: F
authors.lastname: Durif
authors.forename: E
authors.initials: E
authors.lastname: Frenoux
authors.forename: A
authors.initials: A
authors.lastname: Villéger
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lemaire
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000473:pathology / Q000503:physiopathology; D020531:Subthalamic Nucleus / Q000473:pathology* / Q000503:physiopathology; D020530:Subthalamus / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome