Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).
As part of a basic study on the prevention of cerebral injury, ajoene (0.5 mg/d) and oil-macerated garlic extract (OMGE, containing 0.5 mg ajoene/d) were administrated to stroke-prone spontaneously hypertensive rats (SHRSP) among 8 weeks from 9 weeks of age. In the control group, 3 of 10 rats died (30%), whereas all SHRSP treated by ajoene or OMGE survived. Our results suggested that ajoene and OMGE-treatment reduced the mortality and cerebral injury in SHRSP. The levels of thiobarbituric acid reactive substance (TBARS) and the enzymatic activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) in the serum of stroke stage of SHRSP were measured. The results obtained were as follows; the TBARS level of the ajoene and OMGE-treated groups were lower than those of control groups. On the other hand, the GSH-Px and SOD activities of the ajoene and OMGE-treated groups were higher. Our results suggested that ajoene and OMGE were capable of having prophylactic effects on cerebral injury in SHRSP.
Yamada
Norihiko
N
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd, Aichi, Japan.
Hattori
Atsuhiko
A
Nishikawa
Tomoaki
T
Fukuda
Hiroyuki
H
Fujino
Tsuchiyoshi
T
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D004220:Disulfides / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D013454:Sulfoxides; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D004220:Disulfides; D010975:Platelet Aggregation Inhibitors; D013454:Sulfoxides; D017392:Thiobarbituric Acid Reactive Substances; C048980:ajoene; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase