Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats.
The present study was performed to assess and compare a therapeutic efficacy of obidoxime, HI-6, BI-6 and HS-6 administered in equimolar doses and combined with atropine in cyclosarin-poisoned mice and rats. It was demonstrated that all the therapeutic regimens tested, were able to decrease the cyclosarin-induced toxicity significantly - at least 1.5 times. Higher therapeutic ratios, almost three times, were achieved in rats in comparison with mice. The highest therapeutic ratio was achieved for therapeutic regimen consisting of HI-6 and atropine in both mice and rats. Obidoxime was the least effective oxime in the treatment of cyclosarin intoxication. The BI-6 oxime was significantly more efficacious than obidoxime (in both mice and rats) and HS-6 (in rats) but its effectiveness did not reach the efficacy of HI-6.
Bartosová
Lucie
L
Department of Toxicology, Faculty of Military Health Sciences, Hradec Králové, Czech Republic. bartosova@pmfhk.cz
Kuca
Kamil
K
Kunesová
Gabriela
G
D000818:Animals; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D009768:Obidoxime Chloride / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds; D010091:Oximes; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use; D051381:Rats
C118647:BI 6; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011220:Pralidoxime Compounds; D011726:Pyridinium Compounds; C003027:HS 6; D009768:Obidoxime Chloride; C022870:asoxime chloride; C053914:cyclohexyl methylphosphonofluoridate