The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system.
Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.
Mulcahy
Heidi
H
BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
O'Callaghan
Julie
J
O'Grady
Eoin P
EP
Adams
Claire
C
O'Gara
Fergal
F
D000199:Actins / Q000378:metabolism; D001426:Bacterial Proteins / Q000502:physiology*; D001980:Bronchi / Q000382:microbiology*; D002460:Cell Line; D024881:Drug Resistance, Bacterial; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000502:physiology*
D000199:Actins; D001426:Bacterial Proteins; D016601:RNA-Binding Proteins