title: Microevolution of the direct repeat locus of Mycobacterium tuberculosis in a strain prevalent in San Francisco.
abstract: We describe a microevolutionary event of a prevalent strain of Mycobacterium tuberculosis that caused two outbreaks in San Francisco. During the second outbreak, a direct variable repeat was lost. We discuss the mechanisms of this change and the implications of analyzing multiple genetic loci in this context.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine-SFGH, UCSF, 1001 Potrero Avenue, San Francisco General Hospital, Mail Box 0841, San Francisco, CA 94110, USA. midori.kato-maeda@ucsf.edu
authors.forename: Roxanne S
authors.initials: RS
authors.lastname: Aga
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fair
authors.forename: Neil F
authors.initials: NF
authors.lastname: Abernethy
authors.forename: Kathryn
authors.initials: K
authors.lastname: Deriemer
authors.forename: E Antonio
authors.initials: EA
authors.lastname: Paz
authors.forename: L Masae
authors.initials: LM
authors.lastname: Kawamura
authors.forename: Peter M
authors.initials: PM
authors.lastname: Small
authors.forename: Midori
authors.initials: M
authors.lastname: Kato-Maeda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004269:DNA, Bacterial / Q000032:analysis; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D005260:Female; D005798:Genes, Bacterial; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics*; D015995:Prevalence; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012495:San Francisco; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial