Cleft of the secondary palate without cleft lip diagnosed with three-dimensional ultrasound and magnetic resonance imaging in a fetus with Fryns' syndrome.
We present a case of Fryns' syndrome diagnosed prenatally using three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). A cleft of the soft palate was diagnosed using 3D thick-slice ultrasonography. Other sonographic findings included a right diaphragmatic hernia, enlarged echogenic kidneys and severe polyhydramnios. The detection of the cleft palate was instrumental in suggesting the diagnosis of Fryns' syndrome in a fetus which also had a diaphragmatic hernia. These findings were also demonstrated with prenatal MRI. The technique of imaging the soft palate en face using a thick-slice technique is presented.
Benacerraf
B R
BR
Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. BerylBenacerraf@aol.com
Sadow
P M
PM
Barnewolt
C E
CE
Estroff
J A
JA
Benson
C
C
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging; D002972:Cleft Palate / Q000000981:diagnostic imaging*; D019465:Craniofacial Abnormalities / Q000000981:diagnostic imaging; D005260:Female; D005313:Fetal Death; D006548:Hernia, Diaphragmatic / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007668:Kidney / Q000002:abnormalities; D008279:Magnetic Resonance Imaging; D010160:Palate, Soft / Q000000981:diagnostic imaging; D011247:Pregnancy; D013577:Syndrome; D016216:Ultrasonography, Prenatal