Evaluation of diagnostic assays for hepatitis E virus in outbreak settings.
Hepatitis E virus (HEV) is a major cause of hepatitis. We evaluated five HEV antibody diagnostic assays by using outbreak specimens. The Abbott immunoglobulin G (IgG), Genelabs IgG, and Walter Reed Army Institute of Research (WRAIR) IgM assays were about 90% sensitive; the Abbott IgG and WRAIR total Ig and IgM assays were more than 90% specific.
Myint
Khin Saw Aye
KS
Department of Virology, USAMC-AFRIMS, 315/6 Rajvithi Road, Bangkok 1040, Thailand. myintk@afrims.org
Endy
Timothy P
TP
Gibbons
Robert V
RV
Laras
Kanti
K
Mammen
Mammen P
MP
Sedyaningsih
Endang R
ER
Seriwatana
Jitvimol
J
Glass
Jonathan S
JS
Narupiti
Sumitda
S
Corwin
Andrew L
AL
D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis; D004196:Disease Outbreaks; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D016752:Hepatitis E virus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods / Q000592:standards; D012189:Retrospective Studies
D004279:DNA, Viral; D006508:Hepatitis Antibodies