Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.
(1)H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.
Tsang
Tsz M
TM
Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, SW7 2AZ, United Kingdom.
Huang
Jeffrey T-J
JT
Holmes
Elaine
E
Bahn
Sabine
S
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D004200:Diseases in Twins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D007937:Leukapheresis; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D019906:Nuclear Magnetic Resonance, Biomolecular; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*; D018433:Twin Studies as Topic; D014430:Twins, Monozygotic / Q000378:metabolism*
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL