Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation.
Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.
Diergaarde
Leontien
L
Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. l.diergaarde@vumc.nl
Schoffelmeer
Anton N M
AN
De Vries
Taco J
TJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007266:Inhibition, Psychological; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012201:Reward; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol