title: De novo chiral amino alcohols in catalyzing asymmetric additions to aryl aldehydes.
abstract: [reaction: see text] A de novo structural class of chiral amino alcohol catalysts has been identified through a synergistic effort combining novel architectures from [4 + 3] cycloadditions and quantum mechanical interaction field predictions that closely match subsequent experimental measurements.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: James C
authors.initials: JC
authors.lastname: Ianni
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Antoline
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Marisa C
authors.initials: MC
authors.lastname: Kozlowski
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry* / Q000145:classification; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000605:Amino Alcohols