title: Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals.
abstract: The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Klos
authors.forename: J E
authors.initials: JE
authors.lastname: Ahlskog
authors.forename: K A
authors.initials: KA
authors.lastname: Josephs
authors.forename: H
authors.initials: H
authors.lastname: Apaydin
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
authors.forename: M W
authors.initials: MW
authors.lastname: DeLucia
authors.forename: D W
authors.initials: DW
authors.lastname: Dickson
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D008499:Medical Records; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D051844:alpha-Synuclein / Q000032:analysis*
chemical_list: D051844:alpha-Synuclein