A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities.
A structurally characterized mixed-valent tetranuclear ruthenium-oxo oxalato cluster exhibits anti-viral activities toward R5- and X4-tropic HIV-1, and possesses cytoprotective activity toward HIV-1 infected cells.
Wong
Ella Lai-Ming
EL
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
Sun
Raymond Wai-Yin
RW
Chung
Nancy P-Y
NP
Lin
Chen-Lung Steve
CL
Zhu
Nianyong
N
Che
Chi-Ming
CM
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D020287:In Situ Nick-End Labeling; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010070:Oxalates / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D009942:Organometallic Compounds; D010070:Oxalates; D012428:Ruthenium; D054303:HIV Reverse Transcriptase