title: Correction of copper deficiency improves erythropoietin unresponsiveness in hemodialysis patients with anemia.
abstract: We have encountered five hemodialysis patients who had received enteral nutrition and recovered from erythropoietin-resistant anemia with neutropenia after the correction of copper deficiency. We reduced the required doses of recombinant human erythropoietin (rHuEPO) to maintain the target hematocrit levels and three patients were finally weaned from the rHuEPO therapy. Thus, copper deficiency is involved in erythropoietin-resistant anemia in hemodialysis patients.
authors.affiliation: Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Oyaguchi-Kamimachi, Tokyo.
authors.forename: Terumi
authors.initials: T
authors.lastname: Higuchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsukawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Okada
authors.forename: Osamu
authors.initials: O
authors.lastname: Oikawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujita
authors.forename: Noboru
authors.initials: N
authors.lastname: Fukuda
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000740:Anemia / Q000188:drug therapy*; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood / Q000172:deficiency*; D019327:Copper Sulfate / Q000008:administration & dosage / Q000627:therapeutic use; D003677:Deficiency Diseases / Q000209:etiology / Q000628:therapy; D004750:Enteral Nutrition / Q000009:adverse effects*; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D011994:Recombinant Proteins; D006435:Renal Dialysis; D017211:Treatment Failure
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D003300:Copper; D002570:Ceruloplasmin; D019327:Copper Sulfate