Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue.
A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neoplasm-associated alterations in transcriptional or post-transcriptional mechanisms.
Zimmermann
Uwe
U
Department of Urology, University of Greifswald, Fleischmannstr. 42-44, D-17487 Greifswald, Germany.
Junker
Heike
H
Krämer
Fabian
F
Balabanov
Stefan
S
Kleist
Britta
B
Kammer
Winfried
W
Nordheim
Alfred
A
Walther
Reinhard
R
D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015180:Electrophoresis, Gel, Two-Dimensional; D015972:Gene Expression Regulation, Neoplastic; D005854:Germ Cells / Q000166:cytology / Q000201:enzymology*; D005982:Glutathione Transferase / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D040901:Proteomics; D012333:RNA, Messenger / Q000378:metabolism; D018239:Seminoma / Q000201:enzymology*; D013736:Testicular Neoplasms / Q000201:enzymology*; D014158:Transcription, Genetic
D015415:Biomarkers; D012333:RNA, Messenger; C483009:GSTM3 protein, human; D005982:Glutathione Transferase