Sequentiality and processivity of nuclear receptor coregulators in regulation of target gene expression.
A series of data has accumulated over the past five years that raises questions about our current understanding of the transcriptional process and its regulation. Following the discovery of coactivators for nuclear receptors (NRs), a large number of these molecules have been reported in the literature. This perspective will summarize some opinions on the significance of this large number of factors.
O'Malley
Bert W
BW
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.