title: Network growth models and genetic regulatory networks.
abstract: We study a class of growth algorithms for directed graphs that are candidate models for the evolution of genetic regulatory networks. The algorithms involve partial duplication of nodes and their links, together with the innovation of new links, allowing for the possibility that input and output links from a newly created node may have different probabilities of survival. We find some counterintuitive trends as the parameters are varied, including the broadening of the in-degree distribution when the probability for retaining input links is decreased. We also find that both the scaling of transcription factors with genome size and the measured degree distributions for genes in yeast can be reproduced by the growth algorithm if and only if a special seed is used to initiate the process.
authors.affiliation: Physics Department and Center for Nonlinear and Complex Systems, Duke University, Durham, North Carolina 27514, USA.
authors.forename: D V
authors.initials: DV
authors.lastname: Foster
authors.forename: S A
authors.initials: SA
authors.lastname: Kauffman
authors.forename: J E S
authors.initials: JE
authors.lastname: Socolar
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D049109:Cell Proliferation; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D006128:Growth / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors