Neural correlates of a default response in a delayed go/no-go task.
Working memory, the ability to temporarily retain task-relevant information across a delay, is frequently investigated using delayed matching-to-sample (DMTS) or delayed Go/No-Go tasks (DGNG). In DMTS tasks, sample cues instruct the animal which type of response has to be executed at the end of a delay. Typically, performance decreases with increasing delay duration, indicating that working memory fades across a delay. However, no such performance decrease has been found when the sample cues exist of present vs. absent stimuli, suggesting that pigeons do not rely on working memory, but seem to respond by default in those trials. We trained 3 pigeons in a DGNG task and found a similar default response pattern: The diverging slopes of the retention functions on correct Go and No-Go trials suggested that pigeons by default omitted their response following No-Go stimuli, but actively retained task-relevant information across the delay for successful responses on Go trials. We conducted single-cell recordings in the avian nidopallium caudolaterale, a structure comparable to the mammalian prefrontal cortex. On Go trials, many neurons displayed sustained elevated activity during the delay preceding the response, replicating previous findings and suggesting that task-relevant information was neurally represented and maintained across the delay. However, the same units did not show enhanced delay activity preceding correct response suppressions in No-Go trials. This activation-inactivation pattern presumably constitutes a neural correlate of the default response strategy observed in the DGNG task.
Kalenscher
Tobias
T
Institute of Cognitive Neuroscience, Department of Biopsychology,Ruhr-universität Bochum, Germany. Tobias.Kalenscher@ruhr-uni-bochum.de
Güntürkün
Onur
O
Calabrese
Pasquale
P
Gehlen
Walter
W
Kalt
Thomas
T
Diekamp
Bettina
B
D000818:Animals; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology*; D010856:Columbidae; D003216:Conditioning, Operant / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D007266:Inhibition, Psychological; D008570:Memory, Short-Term / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology