A classical QSAR study on some platelet aggregation inhibitors.
Cardiovascular diseases are still the main cause of morbidity and mortality in the world. Anti-platelet drugs have found clinical application in the secondary prevention of vascular events including acute myocardial infarction, stroke and cardiovascular death. In the present review, we have developed sixteen quantitative structure-activity relationships (QSAR) for different sets of compounds that are X-phenols (I), X-catechols (II), caffeic acid amides (III), X-alcohols (IV), 1,4-naphthoquinones (V), tetrahydronaphthalenes (VI), phenoxyacetaldehyde guanylhydrazones (VII), pyrrolobenzylisoquinolines (VIII) and phosphonic acids (IX) with respect to their anti-platelet activities. QSAR results have shown that the anti-platelet activities of these compounds are largely dependent not only on their hydrophobicity, but also on the influence of their molar refractivity.
Verma
Rajeshwar P
RP
Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu
D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors