title: New potential inhibitors of cyclin-dependent kinase 4: design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation.
abstract: A simple and efficient synthesis of 2-amino pyrido[2,3-d]pyrimidine derivatives was accomplished via a three-component reaction under microwave irradiation without catalyst. This method had many dramatic advantages such as the short reaction time, high yield, and broad substrate scope, as well as convenient operation. We provide new series of potential biologically active compounds as inhibitors of Cdk4.
authors.affiliation: Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Xuzhou, Jiangsu 221009, PR China. laotu2001@263.net
authors.forename: Shujiang
authors.initials: S
authors.lastname: Tu
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zhu
authors.forename: Jianing
authors.initials: J
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Runhong
authors.initials: R
authors.lastname: Jia
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Junyong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D008872:Microwaves; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011725:Pyridines; D011743:Pyrimidines; D051358:Cyclin-Dependent Kinase 4