title: ESAT-6 peptide recognition by bovine CD8+ lymphocytes of naturally infected cows in herds from southern Italy.
abstract: The aim of this study was to define epitopes of Mycobacterium bovis from ESAT-6 (early secretory antigen of 6 kDa) recognized by CD8+ T lymphocytes from cows naturally infected with Mycobacterium bovis. We found that bovine CD8+ T cells recognized 10 out of 11 ESAT-6 peptides tested.
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi 3, 90100 Palermo, Italia.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vitale
authors.forename: Stefano
authors.initials: S
authors.lastname: Reale
authors.forename: Enrico
authors.initials: E
authors.lastname: Petrotta
authors.forename: Santo
authors.initials: S
authors.lastname: Caracappa
authors.forename: Annalisa
authors.initials: A
authors.lastname: Barera
authors.forename: Marco Pio
authors.initials: MP
authors.lastname: La Manna
authors.forename: Pasquale
authors.initials: P
authors.lastname: Macaluso
authors.forename: Nadia
authors.initials: N
authors.lastname: Caccamo
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Hans Martin
authors.initials: HM
authors.lastname: Vordermeier
authors.forename: Guido
authors.initials: G
authors.lastname: Sireci
authors.forename: Alfredo
authors.initials: A
authors.lastname: Salerno
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D001426:Bacterial Proteins; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D002417:Cattle; D002478:Cells, Cultured; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D009163:Mycobacterium bovis / Q000276:immunology*; D012802:Sicily; D014380:Tuberculosis, Bovine / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D018984:Epitopes, T-Lymphocyte; D007371:Interferon-gamma