The risk of neuro-orthopaedic malformations following in-vitro fertilization.
The purpose of this study was to assess the risk of neuro-orthopaedic malformations after in-vitro fertilization. We compared the prevalence of neuro-orthopaedic malformations in two groups of pregnancies conceived either naturally or by in-vitro fertilization, and used multivariate analysis to study the impact of each variable. The results showed a prevalence of 0.89% neuro-orthopaedic malformations in the in-vitro fertilization cohort and 0.32% in the natural conception cohort. The three times greater risk of malformations in the in-vitro fertilization cohort was reduced after adjustment to other variables. We concluded that the increased risk of neuro-orthopaedic malformations after in-vitro fertilization is not due to the technique itself but rather to factors associated with it.
El Hage
Samer
S
Department of Orthopaedic Surgery, Hotel-Dieu de France Hospital, Beirut, Lebanon.
Ghanem
Ismat
I
Safi
Claude Abi
CA
Afif
Nagi
N
Azoury
Joseph
J
Kharrat
Khalil
K
Dagher
Fernand
F
D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D001724:Birth Weight; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D005865:Gestational Age; D006801:Humans; D007861:Lebanon / Q000453:epidemiology; D017880:Limb Deformities, Congenital / Q000453:epidemiology / Q000209:etiology*; D009421:Nervous System Malformations / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies