title: The developing role of receptors and adaptors.
abstract: The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?
authors.affiliation: CRUK Uro-Oncology Group, Department of Oncology, University of Cambridge, c/o Hutchison/MRC Cancer Research Centre, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XZ, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Massie
authors.forename: Ian G
authors.initials: IG
authors.lastname: Mills
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases