title: Uncertainty analysis of relative biological effectiveness of alpha-radiation for human lung exposure.
abstract: Assessment of relative biological effectiveness (RBE) for a radiation in the cases of inhalation of radon progeny and incorporation of plutonium in lung is based on simulation of lung cancer radiation risk for alpha and external reference types of radiation. Specific radiation risk models developed on the results of direct epidemiological studies are used for simulation. These include published risk models for nuclear workers of the Mayak facilities in the former Soviet Union exposed to incorporated plutonium (Kreisheimer et al., 2003; Gilbert et al., 2004) and underground miners exposed to radon progenies (BEIR VI, 1999). Additionally, a lung cancer risk model is developed for a case of population indoor radon exposure. Lung cancer risk related to external exposure is estimated using the risk model developed for the analyses of Japanese atomic bomb survivors (Preston et al., 2003). Uncertainties of risk models parameters are considered and the uncertainties of RBE are estimated using the results of lifetime lung cancer risk simulation, which is done implementing a Monte Carlo approach. Estimated median value of RBE in case of indoor radon exposure is 1.5 with 90% range 0.4-7. In the case of the two models developed by BEIR VI for lung cancer risk due to radon exposure in underground miners, the median values of RBE are 2.1 and 4.4 with 90% ranges 0.3-17 and 0.7-45, respectively. The two different models for lung cancer risk related to plutonium exposure resulted in close estimates of RBE: median value of 12 and 13 with 90% range 4-104 and 4-136, respectively.
authors.affiliation: Institute of Industrial Ecology of Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia. ivy@ecko.uran.ru
authors.forename: Ilia
authors.initials: I
authors.lastname: Yarmoshenko
authors.forename: Ivan
authors.initials: I
authors.lastname: Kirdin
authors.forename: Michael
authors.initials: M
authors.lastname: Zhukovsky
mesh_terms: D000328:Adult; D000512:Alpha Particles / Q000009:adverse effects*; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology; D017687:Radon Daughters / Q000009:adverse effects*; D012062:Relative Biological Effectiveness; D018570:Risk Assessment; D035501:Uncertainty
chemical_list: D002274:Carcinogens, Environmental; D017687:Radon Daughters