Polyoxyethylenated methyl esters of rape oil fatty acids as non-ionic surfactants in a model drug form with albendazole.
Systematic research has been conducted on the applying of Rofams (oxyethylathed rape oil methyl esters) as solubilizing agents of albendazole. Homologous series of Rofams containing average amount of oxyethylene units (nTE) ranging between 20 to 60 was used for investigation. An attempt has been made to apply investigated surface active agents as an auxiliary in production of model tablets with albendazole. Basic morphological parameters of granulates (bulk density, tapped density, Carr index, angle of repose) were determined. The dissolution testing procedure, friability and standard deviation from an average tablet mass were conducted to evaluate properties of produced tablets. The solubility of albendazole increases in the presence of Rofams in the aqueous solutions. The highest amount of albendazole was solubilized in the aqueous solution of Rofam containing 20 oxyethylene units. The increase in the content of oxyethylene units in a molecule of surfactant leads to a subsequent decrease in the amount of solubilized albendazole. Studied compounds can be applied in suggested quantities in the formulation of solid dosage forms. Tablets obtained with their content obeyed standards of Polish Pharmacopoeia. Rofams are increasing the amount of albendazole liberated from the tablets what can result in increasing it's bioavailability.
Woskowicz
Marcin
M
Department of Drug Form Technology, Applied Pharmacy Faculty, Medical University of Lodz. mwoskowicz@pharm.am.lodz.pl
Zgoda
Marian Mikołaj
MM
D015766:Albendazole / Q000737:chemistry* / Q000493:pharmacokinetics; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005229:Fatty Acids, Monounsaturated; D008956:Models, Chemical; D010938:Plant Oils / Q000737:chemistry*; D000074262:Rapeseed Oil; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013607:Tablets
D000981:Antiprotozoal Agents; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D013501:Surface-Active Agents; D013607:Tablets; D015766:Albendazole