Small artery remodeling in hypertension and diabetes.
The development of structural changes in the systemic vasculature is the end result of established hypertension. In essential hypertension, small artery smooth muscle cells are restructured around a smaller lumen, and there is no net growth of the vascular wall, whereas in some secondary forms of hypertension and in non-insulin-dependent diabetes mellitus, a hypertrophic remodeling may be detected. Indices of small resistance artery structure, such as the tunica media to internal lumen ratio, may have a strong prognostic significance in hypertensive patients. Various antihypertensive drugs seem to have different effects on vascular structure. A complete normalization of small resistance artery structure was demonstrated in hypertensive patients, after prolonged and effective therapy with angiotensin-converting enzyme inhibitors, angiotensin II-receptor blockers, and calcium antagonists. Few data are available in diabetic hypertensive patients; however, blockade of the renin-angiotensin system seems to be effective in this regard.
Rizzoni
Damiano
D
Department of Medical and Surgical Sciences, University of Brescia, c/o 2a Medicina Spedali Civili di Brescia, Piazza Spedali Civili 1, 25100 Brescia, Italy. rizzoni@med.unibs.it
Agabiti Rosei
Enrico
E
D001158:Arteries / Q000473:pathology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D006984:Hypertrophy; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology; D014661:Vasoconstriction / Q000502:physiology