title: Larvicidal activity of extracts of Ginkgo biloba exocarp for three different strains of Culex pipiens pallens.
abstract: Ethanolic extracts from the Ginkgo biloba L. exocarp from the Chinese ginkgo were assayed against larvae of three strains of Culex pipiens pallens Coquillett. The chemical compositions were detected using a Hewlett-Packard 6890/5973 mass spectrometric detector. The larvicidal bioassay was carried out according to the recommendations of the World Health Organization. The analysis of the essential oil of ginkgo exocarp showed that its major components are ginkgo acid (85.3%) and ginkgo phenolic (5.69%). The larvicidal bioassay showed that extracts of ginkgo exocarp have LC50 of 18.6, 12.7, and 25.0 mg/liter for deltamethrin-susceptible, deltamethrin-resistant, and field strains, respectively. The acute toxicity concentrations of the ginkgo extracts that killed 50% (LD50) of Wistar rats within 2 wk and young carp within 96 h were 4947.2 mg/kg and 557.9 mg/liter, respectively. These results are promising in creating new, effective, and affordable approaches to mosquito control.
authors.affiliation: Department of Parasitology, Nanjing Medical University, Jiangsu Province Key Lab of Modern Pathogen Biology, Nanjing 210029, People's Republic of China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Sun
authors.forename: Huiqin
authors.initials: H
authors.lastname: Dong
authors.forename: Chongxia
authors.initials: C
authors.lastname: Guo
authors.forename: Jin
authors.initials: J
authors.lastname: Qian
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.forename: Changliang
authors.initials: C
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods; D002347:Carps; D003465:Culex / Q000187:drug effects*; D000431:Ethanol / Q000737:chemistry; D020441:Ginkgo biloba / Q000737:chemistry* / Q000633:toxicity; D007303:Insect Vectors / Q000187:drug effects*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D009032:Mosquito Control; D009822:Oils, Volatile / Q000737:chemistry; D010936:Plant Extracts / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute / Q000662:veterinary*
chemical_list: D009822:Oils, Volatile; D010936:Plant Extracts; D000431:Ethanol