title: [Laboratory Network within the Polio Eradication Initiative (1998-2003): six years of surveillance for acute flaccid paralysis in Spain].
abstract: BACKGROUND
  Worldwide poliomyelitis eradication was proposed in 1988 by the World Health Organization (WHO), based on reaching and maintaining high vaccination coverage and on implementing effective poliovirus infection surveillance systems.
  
  
  METHODS
  In Spain the surveillance system focuses on active searching for acute flaccid paralysis cases through a nine-laboratory network, coordinated by the National Poliovirus Laboratory (NPL) in the National Center of Microbiology, and supported by Autonomous Community epidemiologists. Additionally, the Network sends enterovirus isolation data from other syndromes. The Laboratory Network is responsible for the primary virological study, while the NPL characterizes all polioviruses and the most epidemiologically relevant non-polio enteroviruses.
  
  
  RESULTS
  A total of 54,533 samples were studied during the six-year period, and enteroviruses were detected in 9%. All the polioviruses isolated (n = 196), were characterized as Sabin-like (poliovirus vaccine), and among the non-polio enteroviruses, the most frequent was Echovirus 30. A total of 3% of the samples studied corresponded to the 268 acute flaccid paralysis cases or their contacts.
  
  
  CONCLUSIONS
  According to the results and the WHO virological classification, Spain can be considered polio-free. However, the geographic situation of our country may facilitate the introduction of wild polioviruses that can give rise to imported poliomyelitis. Hence, the laboratory network should actively continue to participate in all the proposed WHO strategies, particularly maintenance of the poliomyelitis eradication infrastructures, and continuing monitoring and vaccination.
authors.affiliation: Laboratorio Nacional de Poliovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. gtralle@isciii.es
authors.forename: Gloria
authors.initials: G
authors.lastname: Trallero
authors.forename: Ana
authors.initials: A
authors.lastname: Avellón
authors.forename: Almudena
authors.initials: A
authors.lastname: Otero
authors.forename: Teresa
authors.initials: T
authors.lastname: de Miguel
authors.forename: Milagros
authors.initials: M
authors.lastname: Alonso
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Breña
mesh_terms: D006801:Humans; D007753:Laboratories / Q000458:organization & administration; D010243:Paralysis / Q000821:virology; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control*; D017955:Poliovirus / Q000302:isolation & purification; D011159:Population Surveillance; D013030:Spain / Q000453:epidemiology