title: A semi-parametric method for describing the age-specific distribution of clinical measurements in cross-sectional study.
abstract: Age-specific distribution of clinical measurements in cross-sectional study is described in this paper. Since the distribution of measurements usually varies with age, a model with an age-dependent structure is needed. We propose here a statistical method for describing the age-specific distribution using an extension of the power-normal-model. The age-dependent parameters are to be estimated through a nonparametric smoothing technique based on the local likelihood method. As a consequence, we can compute a smoothed percentile curve of measurements with reference to age. Several kinds of clinical measurements are analyzed to determine the proposed method.
authors.affiliation: Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
authors.forename: Mohd Muzibur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Kenichi
authors.initials: K
authors.lastname: Satoh
authors.forename: Keiko
authors.initials: K
authors.lastname: Otani
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kambe
authors.forename: Megu
authors.initials: M
authors.lastname: Ohtaki
mesh_terms: D017677:Age Distribution; D000375:Aging / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008274:Magnesium / Q000097:blood; D008297:Male; D009391:Nephelometry and Turbidimetry; D010710:Phosphates / Q000097:blood; D010758:Phosphorus / Q000097:blood; D017967:Zinc Compounds / Q000097:blood
chemical_list: D010710:Phosphates; D017967:Zinc Compounds; C043952:zinc phosphate; D010758:Phosphorus; D002097:C-Reactive Protein; D008274:Magnesium