title: Adrenocorticotropic hormone and dehydroepiandrosterone sulfate levels of rheumatoid arthritis patients treated with glucocorticoids.
abstract: To assess adrenal function with respect to the presence or absence of steroid therapy, we investigated differences in the blood levels of adrenocorticotropic hormone (ACTH) and dehydroepiandrosterone sulfate (DHEAS) in relation to steroid (prednisolone) administration in 123 patients with rheumatoid arthritis (RA). Levels of ACTH and DHEAS were significantly lower in the steroid-treated group than in the non-treated group (ACTH: 11.79 pg/ml vs 27.92 pg/ml) (DHEAS: 418.12 ng/ml vs 883.91 ng/ml) (P<0.0001). We observed no steroid dose-related differences in ACTH levels. However, DHEAS levels showed a slight decrease at a prednisolone dose of 2.5 mg/day, with a significant decrease being observed at a dose of 5 mg/day when statistical adjustments were made for age and sex (P<0.0001). At doses of 7.5 mg/day or greater, DHEAS levels were significantly lower than those for 5 mg/day (P<0.0006). These results suggest that low-dose prednisolone reduces adrenal function in patients with RA. We recommend that doses of prednisolone should be limited to 5 mg/day or less in consideration of adrenal function when treating RA patients. The measurement of ACTH and DHEAS may be useful for evaluating adrenal function in patients with RA.
authors.affiliation: Department of Orthopaedic Surgery, Yukioka Hospital, 2-2-3 Ukita, Kita-ku, Osaka 530-0021, Japan. jimu@yukioka.or.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Yukioka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Komatsubara
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yukioka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Toyosaki-Maeda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yonenobu
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ochi
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone