[Recent advances for research on anti-tumor effects of TNF-related apoptosis-inducing ligand].
Tumor necrosis factor (TNF)-related apoptosis--inducing ligand (TRAIL) is a member of TNF family. TRAIL selectively induces apoptosis in a wide variety of tumor cells, but not most normal cells through binding to its receptors. The ability of TRAIL to induce apoptosis in a large number of tumors has stimulated interest in TRAIL as a tumor therapeutic agent.
Yao
Gen-Hong
GH
Department of Transfusion, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
Hou
Ya-Yi
YY
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000187:drug effects*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand