Copper-catalyzed cycloisomerizations of 5-en-1-yn-3-ols.
[reaction: see text] The Cu(I)-catalyzed cycloisomerization of tertiary 5-en-1-yn-3-ols with an 1,2-alkyl shift affords stereoselectively tri- and tetracyclic compounds of high molecular complexity. These results are in agreement with a mechanism in which the cyclopropanation precedes the rearrangement.
Fehr
Charles
C
Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva, Switzerland. charles.fehr@firmenich.com
Farris
Iris
I
Sommer
Horst
H