title: [Acute airway obstruction during chemotherapy-induced agranulocytosis with fever].
abstract: Acute airway obstruction caused by mucoid impaction can cause sometimes life-threatening respiratory distress. Bronchial plugging is usually observed in subjects with chronic diseases such as asthma, allergic bronchopulmonary aspergillosis, or cystic fibrosis. In children, it can be related to heart failure. Acute airway obstruction in a patient without a chronic respiratory disease is exceptional. We report the case of a patient who developed bronchial plugs obstructing the bronchi during a period of agranulocytosis induced by chemotherapy. The patient experienced acute respiratory distress with asphyxia. The plugs were composed of fibrin and required several fibroscopic procedures for clearance. To our knowledge, this is the first case report of acute airway obstruction by plugging during a period of agranulocytosis.
authors.affiliation: Service de Pneumologie, Hôpital Intercommunal de Fréjus/Saint Raphaël, 240, avenue de Saint-Lambert, BP 110, 83608 Fréjus Cedex. frederic.vandenbos@wanadoo.fr
authors.forename: F
authors.initials: F
authors.lastname: Vandenbos
authors.forename: Ph
authors.initials: P
authors.lastname: Deswardt
authors.forename: H
authors.initials: H
authors.lastname: Hyvernat
authors.forename: F
authors.initials: F
authors.lastname: Burel-Vandenbos
authors.forename: G
authors.initials: G
authors.lastname: Bernardin
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced*; D000402:Airway Obstruction / Q000209:etiology* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001991:Bronchitis / Q000150:complications / Q000209:etiology* / Q000601:surgery; D003561:Cytarabine / Q000009:adverse effects; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000601:surgery
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone