Expression of RAB27B is up-regulated in senescent human cells.
Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts.
Fujii
Michihiko
M
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan.
Kawai
Yoshinori
Y
Endoh
Morio
M
Hossain
Mohammad Nazir
MN
Nakabayashi
Kazuhiko
K
Ayusawa
Dai
D
D002461:Cell Line, Transformed; D016922:Cellular Senescence / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D000075745:rab27 GTP-Binding Proteins
D016159:Tumor Suppressor Protein p53; D000075745:rab27 GTP-Binding Proteins; C066694:RAB27A protein, human; C512960:Rab27B protein, human; D020691:rab GTP-Binding Proteins