[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury].
OBJECTIVE
To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI).


METHODS
Thirty-six patients scheduled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT + PRO group, 9 patients in each group. Changes of superoxide dismutase (SOD), lipid peroxide (LPO), ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), alanine aminotransferase (ALT) activity, and the ultrastructure of liver tissue were dynamically observed.


RESULTS
Compared with the control group, SOD activity was significantly higher, LPO concentration, TXB2/6-keto-PGF1alpha ratio and ALT value were significantly lower (P < 0.05 and P < 0.01) in the LGT group, the PRO group and the LGT + PRO group during HIRI, with the abnormal changes of hepatic ultrastructure 25 min after reperfusion significantly alleviated in the three treated group.


CONCLUSIONS
Combination of ligustrazine and propofol shows protective effect on liver by decreasing oxygen free radical level, reducing lipid peroxidation and adjusting TXA2/PGI2 imbalance after hepatic ischemia-reperfusion in patients undergoing hepatic cancer surgery.
Wang
Wan-Tie
WT
Department of Pathophysiology, Wenzhou Medical College, Zhejiang. wzwwt@tom.com
Lin
Li-Na
LN
Wu
Jin-Ze
JZ
Hu
Zhengyang
Z
Xie
Kejian
K
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008099:Liver / Q000098:blood supply*; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D011719:Pyrazines; D015121:6-Ketoprostaglandin F1 alpha; D013482:Superoxide Dismutase; C017953:tetramethylpyrazine; D015742:Propofol