[Preoperative hepatic and regional arterial infusion chemotherapy in the prevention of liver metastasis after colorectal cancer surgery].
OBJECTIVE
To investigate the effects of preoperative hepatic and regional arterial infusion chemotherapy (PHRAIC) in the prevention of liver metastasis of colorectal cancer after surgery.


METHODS
110 patients of colorectal cancer underwent perfusion of 3 anti-tumor drugs into the hepatic artery and nutrient artery of the tumor respectively, radical surgery of the colorectal cancer 7 days after, and then general venous chemotherapy 3 weeks after operation, 112 patients underwent radical surgery of the colorectal cancer and general venous chemotherapy 3 weeks after operation. Follow-up was carried out every month with a follow-up period of 34 months +/- 3 months.


RESULTS
There were no significant difference in post-operational complications between these 2 groups. The 3-year liver metastasis rate, 3-year tumor-free survival rate, overall survival rate, and median survival time of the stage III patients in the PHRAIC group were 12.7%, 82.3%, 87.7%, and 40 months +/- 5 months, all significantly better than those in the control group (28.3%, 58.7%, 75.5%, and 36 months +/- 3 months respectively, P < 0.05 or P < 0.01).


CONCLUSIONS
PHRAIC reduces the liver metastasis of colorectal cancer after radical surgery and improves the survival of the stage III patients.
Xu
Jian-min
JM
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhong
Yun-shi
YS
Niu
Wei-xin
WX
Ren
Li
L
Lai
Yan-han
YH
Wang
Jian-hua
JH
Yan
Zhi-ping
ZP
Cheng
Jie-min
JM
Qin
Xin-yu
XY
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003107:Colorectal Surgery; D005260:Female; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011300:Preoperative Care / Q000379:methods*; D016019:Survival Analysis
D000970:Antineoplastic Agents