Bioreduction of aldehydes and ketones using Manihot species.
Biocatalysis constitutes an important tool in organic synthesis, especially for the preparation of chiral molecules of biological interest. A series of aliphatic and aromatic aldehydes and two ketones were reduced using plant cell preparations from Manihot esculenta and Manihot dulcis roots. The reduced products were typically obtained in excellent yields (80-96%), and with excellent enantiomeric excess (94-98%), except for vanillin. Esters, a nitrile, and an amide were also examined, but were not reduced. Preliminary conversion rate studies are reported. This is the first attempt to perform the biotransformation of carbonyl compounds using Manihot species.
Machado
Luciana L
LL
Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60451-970 Fortaleza-Ceara, Caixa Postal 60021, Brazil.
Souza
João Sammy N
JS
de Mattos
Marcos Carlos
MC
Sakata
Solange K
SK
Cordell
Geoffrey A
GA
Lemos
Telma L G
TL
D000447:Aldehydes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D002365:Manihot / Q000737:chemistry*; D010084:Oxidation-Reduction; D017550:Spectroscopy, Fourier Transform Infrared
D000447:Aldehydes; D007659:Ketones