title: Urinary follicle-stimulating hormone (FSH) is more effective than recombinant FSH in older women in a controlled randomized study.
abstract: OBJECTIVE
  The following study was conducted to determine which FSH, recombinant or urinary, works better in older women.
  
  
  METHODS
  We conducted a controlled randomized study in a single university IVF center.
  
  
  METHODS
  University IVF center.
  
  
  METHODS
  Women (N = 257) over 39 years old undergoing IVF.
  
  
  METHODS
  The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol.
  
  
  METHODS
  Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained.
  
  
  RESULTS
  Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences.
  
  
  CONCLUSIONS
  Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.
authors.affiliation: Department of Obstetrics, Gynecology and Perinatology, Policlinico Umberto I Hospital, La Sapienza University, Rome, Italy.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Mohamed
authors.forename: Marco
authors.initials: M
authors.lastname: Sbracia
authors.forename: Arianna
authors.initials: A
authors.lastname: Pacchiarotti
authors.forename: Giulietta
authors.initials: G
authors.lastname: Micara
authors.forename: Antonella
authors.initials: A
authors.lastname: Linari
authors.forename: Daniela
authors.initials: D
authors.lastname: Tranquilli
authors.forename: Salomé M B
authors.initials: SM
authors.lastname: Espinola
authors.forename: Cesare
authors.initials: C
authors.lastname: Aragona
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage* / Q000235:genetics; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000453:epidemiology* / Q000628:therapy*; D007558:Italy / Q000453:epidemiology; D011247:Pregnancy / Q000706:statistics & numerical data; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome; D050477:Urofollitropin / Q000008:administration & dosage*
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; D050477:Urofollitropin