title: Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variant.
abstract: To test the significance of human papillomavirus (HPV) type 16 and HPV16 E6 variants as risk factors for viral persistence and progression to high-grade lesion, we did a nested case-control study within a cohort study of >15,000 Caucasian French women. Three groups infected with high-risk HPV were compared: (a) women with cleared infection (controls, n = 201), (b) women with persistent infection (cases, n = 87), and (c) women who progressed into high-grade lesion (cases, n = 58). Women with persistent HPV infection and those that progressed into high-grade lesions were likelier to harbor HPV16 than other high-risk HPV types [odds ratio (OR), 2.4; 95% confidence interval (95% CI), 1.3-4.3 and OR, 4.2; 95% CI, 2.2-8.1, respectively]. Notably, especially elevated ORs of persistence (3.0; 95% CI, 1.4-6.7) and progression (6.2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions.
authors.affiliation: Johannes Gutenberg University, Medical Microbiology, Mainz, Germany.
authors.forename: Martha
authors.initials: M
authors.lastname: Grodzki
authors.forename: Guillaume
authors.initials: G
authors.lastname: Besson
authors.forename: Christine
authors.initials: C
authors.lastname: Clavel
authors.forename: Annie
authors.initials: A
authors.lastname: Arslan
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Philippe
authors.initials: P
authors.lastname: Birembaut
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Zehbe
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016017:Odds Ratio; D009856:Oncogene Proteins, Viral / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D012097:Repressor Proteins / Q000302:isolation & purification*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins