[Renin-angiotensin system in atherosclerosis].
The renin-angiotensin system(RAS) has been demonstrated to play a critical role in initiation and progression of atherosclerosis, thereby contributing to development cardiovascular diseases. Angiotensin II(Ang II), major substrate in RAS, stimulates atherosclerosis through various processes such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic effects of Ang II are mediated by reactive oxygen species(ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
Fukuda
Daiju
D
Department of Cardiovascular Medicine, University of Tokyo.
Sata
Masataka
M
D000804:Angiotensin II / Q000502:physiology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000166:cytology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications; D017382:Reactive Oxygen Species; D012084:Renin-Angiotensin System / Q000502:physiology*
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D017382:Reactive Oxygen Species; D000804:Angiotensin II