title: Influence of hypothyroidism induced by thiamazole on the toxicity of amitriptyline in chick embryos.
abstract: The effect of hypothyroidism induced by thiamazole on the toxicity of amitriptyline was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubation. The control group was given 0.2 ml/egg of physiological saline in the same manner. Amitriptyline at 1 mg/egg was injected into the air sac of fertilized eggs on the 16th day of incubation. Electrocardiograms were recorded 0 to 60 min after the injection. After the injection of amitriptyline into the thiamazole-treated eggs, the heart rate was significantly decreased compared with the untreated eggs. These findings indicate that hypothyroidism induced by thiamazole has a marked influence on the toxicity of amitriptyline in chick embryos.
authors.affiliation: Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, Shibakoen, Tokyo, Japan. yoshiyama-yj@kyoritsu-ph.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshiyama
authors.forename: Motoko
authors.initials: M
authors.lastname: Kanke
mesh_terms: D000639:Amitriptyline / Q000633:toxicity*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D013956:Antithyroid Agents; D001835:Body Weight / Q000187:drug effects; D002642:Chick Embryo; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007037:Hypothyroidism / Q000139:chemically induced* / Q000378:metabolism*; D008713:Methimazole
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013956:Antithyroid Agents; D000639:Amitriptyline; D008713:Methimazole