Direct catalytic asymmetric anti-selective Mannich-type reactions.
The simple chiral pyrrolidine catalyzed asymmetric anti-selective Mannich-type reaction is presented; the reaction gives the corresponding amino acid derivatives with 10:1- >19:1 dr and 97-99% ee.
Ibrahem
Ismail
I
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Córdova
Armando
A
D002384:Catalysis; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*
D011759:Pyrrolidines