title: Influence of cardiac hemodynamic parameters on coronary artery opacification with 64-slice computed tomography.
abstract: The purpose of this study was to evaluate the influence of ejection fraction (EF), stroke volume (SV), heart rate, and cardiac output (CO) on coronary artery opacification with 64-slice computed tomography (CT). Sixty patients underwent, retrospectively, electrocardiography-gated 64-slice CT coronary angiography. Left ventricular EF, SV, and CO were calculated with semi-automated software. Attenuation values were measured and contrast-to-noise ratios (CNRs) were calculated in the proximal right coronary artery (RCA) and left main artery (LMA). Mean EF during scanning was 61.5+/-12.4%, SV was 63.2+/-15.6 ml, heart rate was 62.5+/-11.8 beats per minute (bpm), and CO was 3.88+/-1.06 l/min. There was no significant correlation between the EF and heart rate and the attenuation and CNR in either coronary artery. A significant negative correlation was found in both arteries between SV and attenuation (RCA r=-0.26, P<0.05; LMA r=-0.34, P<0.01) and between SV and CNR (RCA r=-0.26, P<0.05; LMA r=-0.26, P<0.05). Similarly, a significant negative correlation was found between the CO and attenuation (RCA r=-0.42, P<0.05; LMA r=-0.56, P<0.001) and between the CO and CNR (RCA r=-0.39, P<0.05; LMA r=-0.44, P<0.001). The actual hemodynamic status of the patient influences the coronary artery opacification with 64-slice CT, in that vessel opacification decreases as SV and CO increase.
authors.affiliation: Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
authors.forename: Lars
authors.initials: L
authors.lastname: Husmann
authors.forename: Hatem
authors.initials: H
authors.lastname: Alkadhi
authors.forename: Thomas
authors.initials: T
authors.lastname: Boehm
authors.forename: Sebastian
authors.initials: S
authors.lastname: Leschka
authors.forename: Tiziano
authors.initials: T
authors.lastname: Schepis
authors.forename: Pascal
authors.initials: P
authors.lastname: Koepfli
authors.forename: Lotus
authors.initials: L
authors.lastname: Desbiolles
authors.forename: Borut
authors.initials: B
authors.lastname: Marincek
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Kaufmann
authors.forename: Simon
authors.initials: S
authors.lastname: Wildermuth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002302:Cardiac Output; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012107:Research Design; D012189:Retrospective Studies; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left