Pd(0)-Catalyzed PMHS reductions of aromatic acid chlorides to aldehydes.
[reaction: see text] Contrary to previous reports, polymethylhydrosiloxane (PMHS) under Pd(0) catalysis can efficiently reduce aryl acid chlorides to their corresponding aldehydes without requiring an additional reductant, provided the reactions are run in the presence of fluoride.
Lee
Kyoungsoo
K
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Maleczka
Robert E
RE
D000447:Aldehydes / Q000138:chemical synthesis*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*
D000447:Aldehydes; D002712:Chlorides; D012833:Siloxanes; C402373:poly(methylhydrosiloxane); D010165:Palladium; D005459:Fluorides