title: [Systemic lupus erythematosus with neurologic onset and secondary antiphospholipid syndrome. A Case Study].
abstract: A 39-years-old woman was admitted to our hospital with musculoskeletal complaints (myalgias and symmetric arthralgias in proximal interphalangeal, metacarpophalangeal joints of the hands and in knees), systemic symptoms like fever, fatigue, malaise and a six months previous history of a transient ischemic attack. The presence of antibodies to double-stranded deoxyribonucleic-acid (DNA) and antiphospholipid antibodies led to the diagnosis of systemic lupus erythematosus with secondary antiphospholipid syndrome. Cerebral infarction develops significantly more often in patients with lupus and antiphospholipid antibodies, but other clinical syndromes are associated with lupus anticoagulant: cognitive dysfunction, seizures, polyneuropathy, aseptic meningitis, myelopathy.
authors.affiliation: Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi Facultatea de Medicină Generală Clinica a VI-a Medicală.
authors.forename: Corina
authors.initials: C
authors.lastname: Dima-Cozma
authors.forename: G I
authors.initials: GI
authors.lastname: Pandele
authors.forename: Elena
authors.initials: E
authors.lastname: Rezuş
authors.forename: Aurora
authors.initials: A
authors.lastname: Constantinescu
authors.forename: Maria Sultana
authors.initials: MS
authors.lastname: Mihailovici
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000097:blood; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D007155:Immunologic Factors; D007166:Immunosuppressive Agents