title: Building bridges to the cortex.
abstract: Innervation of the neocortex by the thalamus is dependent on the precise coordination of spatial and temporal guidance cues. In this issue of Cell, work by López-Bendito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are essential for axonal navigation between the thalamus and the neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling.
authors.affiliation: Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA.
authors.forename: Carina
authors.initials: C
authors.lastname: Hanashima
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Molnár
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D020890:Neuregulin-1 / Q000378:metabolism*; D066247:Receptor, ErbB-4; D015398:Signal Transduction; D013788:Thalamus / Q000166:cytology* / Q000378:metabolism
chemical_list: D020890:Neuregulin-1; D066246:ErbB Receptors; D066247:Receptor, ErbB-4