title: Risk factors for death in acquired immunodeficiency syndrome-associated disseminated histoplasmosis.
abstract: We performed a retrospective study of 164 human immunodeficiency virus (HIV)-infected patients with disseminated histoplasmosis to identify the risk factors for death. Death occurred in 32% of the cases. Univariate analysis identified the following risk factors: diarrhea (odds ratio [OR] = 3.9, P = 0.001), neurologic manifestations (OR = 5.8, ; P = 0.001), hemoglobin level < 8.0g/dL (OR = 2.7, P = 0.004), urea level 2 times the normal upper limit (OR = 5.0, P < 0.001), creatinine level > 1.5 mg/dL (OR = 2.9, P = 0.005), aspartate aminotransferase (AST) level > 2.5 times the normal upper limit (OR = 3.1, P = 0.01), respiratory insufficiency (OR = 9.7, P < 0.001), sepsis (OR = 20.2, P < 0.001), and acute renal failure (OR = 2.5, P = 0.011). A hemoglobin level < 8.0 g/dL (OR = 3.8, P = 0.008), an AST level >or= 2.5 times the normal limit (OR = 1.0, P = 0.007), acute renal failure (OR = 2.96, P = 0.015), and respiratory insufficiency (OR = 12.2, P = 0.01) were independent risk factors for death.
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina, Hospital Universitário Walter Cantídio. efdaher@for.terra.com.br
authors.forename: Elizabeth
authors.initials: E
authors.lastname: de Francesco Daher
authors.forename: Fernando Antonio
authors.initials: FA
authors.lastname: de Sousa Barros
authors.forename: Geraldo Bezerra
authors.initials: GB
authors.lastname: da Silva Júnior
authors.forename: Christianne Fernandes Valente
authors.initials: CF
authors.lastname: Takeda
authors.forename: Rosa Maria Salani
authors.initials: RM
authors.lastname: Mota
authors.forename: Marúsia Thomaz
authors.initials: MT
authors.lastname: Ferreira
authors.forename: Julieta Cunha
authors.initials: JC
authors.lastname: Martins
authors.forename: Soraya Alves Jacinto
authors.initials: SA
authors.lastname: Oliveira
authors.forename: Oswaldo Augusto
authors.initials: OA
authors.lastname: Gutiérrez-Adrianzén
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D001774:Blood Chemical Analysis; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006660:Histoplasmosis / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors