Organocatalytic direct michael reaction of ketones and aldehydes with beta-nitrostyrene in brine.
We have developed a direct, asymmetric Michael reaction that can be performed in brine or seawater without addition of organic solvents. A bifunctional catalyst with long hydrophobic alkyl chains efficiently catalyzed Michael reactions and afforded the desired products in excellent yield with high enantiomeric excess, even when only an equal molar ratio of the donor to acceptor was used.
Mase
Nobuyuki
N
Department of Molecular Science, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Japan.
Watanabe
Kaori
K
Yoda
Hidemi
H
Takabe
Kunihiko
K
Tanaka
Fujie
F
Barbas
Carlos F
CF