De novo chiral amino alcohols in catalyzing asymmetric additions to aryl aldehydes.
[reaction: see text] A de novo structural class of chiral amino alcohol catalysts has been identified through a synergistic effort combining novel architectures from [4 + 3] cycloadditions and quantum mechanical interaction field predictions that closely match subsequent experimental measurements.
Huang
Jian
J
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
Ianni
James C
JC
Antoline
Jennifer E
JE
Hsung
Richard P
RP
Kozlowski
Marisa C
MC
D000447:Aldehydes / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry* / Q000145:classification; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D000605:Amino Alcohols