Immunosuppressive treatment for mixed connective tissue disease may facilitate the development of adult T cell leukemia/lymphoma in a HTLVI carrier.
A 66-year-old woman who was positive for human T-lymphotropic virus type I (HTLV-I) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTL-V-I-related inflammatory diseases, however the development of ATLL during the treatment of HTL-V-I-related MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTD-causative anti-HTLV-I immune response and anti-ATLL immune response.
Fujiwara
Hiroshi
H
Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima, Sakuragaoka.
Nakamura
Daisuke
D
Kukita
Toshimasa
T
Hamada
Heiichiro
H
Ozaki
Atsuo
A
Matsushita
Kakushi
K
Matsumoto
Tadashi
T
Tei
Chuwa
C
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015139:Blotting, Southern; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000150:complications; D008775:Methylprednisolone / Q000627:therapeutic use; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood; D013937:Thymidine Kinase / Q000097:blood
D001323:Autoantibodies; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D011239:Prednisolone; D013937:Thymidine Kinase; D008775:Methylprednisolone