Structure-activity studies of oxazolidinone analogs as RNA-binding agents.
We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.
Means
John
J
Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
Katz
Steven
S
Nayek
Abhijit
A
Anupam
Rajaneesh
R
Hines
Jennifer V
JV
Bergmeier
Stephen C
SC
D015195:Drug Design; D008024:Ligands; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D008024:Ligands; D023303:Oxazolidinones; D012313:RNA