title: Beraprost sodium-induced hypotension in two patients after cardiac surgery.
abstract: Two episodes of hypotension caused by oral beraprost sodium administration following cardiac surgery are described. The first case was a 67-year-old female who underwent concomitant surgery for mitral valve replacement, tricuspid annuloplasty, and a radiofrequency maze procedure for atrial fibrillation. The second case was a 45-year-old female who underwent 4-vessel coronary artery bypass grafting associated with endarterectomy in the right coronary artery. Beraprost sodium was administered for the treatment of residual pulmonary hypertension in the first case, and was initiated as an antiplatelet agent following coronary endarterectomy in the second case. Hypotension occurred at approximately one hour after beraprost sodium administration in both cases. Careful observation to prevent this adverse effect is critical after the administration of beraprost sodium, especially in patients who have undergone cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Teikyo University School of Medicine, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Akio
authors.initials: A
authors.lastname: Kawasaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Neya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kugawa
authors.forename: Tamuro
authors.initials: T
authors.lastname: Hayama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000601:surgery; D006348:Cardiac Surgical Procedures; D017115:Catheter Ablation; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000601:surgery; D048909:Diabetes Complications / Q000150:complications; D004691:Endarterectomy; D011464:Epoprostenol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000601:surgery; D011183:Postoperative Complications; D014262:Tricuspid Valve Insufficiency / Q000601:surgery; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; C048081:beraprost; D011464:Epoprostenol