Role of WNT signaling in normal and malignant hematopoiesis.
The WNT pathway is a powerful signaling pathway that plays a crucial role in cell fate determination, survival, proliferation and movement in variety of tissues. Abnormalities in the WNT signaling pathway have been implicated in a number of diseases, most notably cancer. Recent exciting evidence suggests that WNT signaling also plays an important role in hematopoietic stem cell self-renewal and progenitor development. In this review we discuss current state of knowledge on WNT signaling in hematopoiesis and extend our focus on aberrant WNT signaling in hematological malignancies.
Khan
N I
NI
Westmead Institute for Cancer Research, Westmead Millennium Institute, University of Sydney, Westmead, Australia.
Bendall
L J
LJ
D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D008223:Lymphoma / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D051153:Wnt Proteins