The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: a call for better disease recognition and evaluation of adjuncts to antifungal therapy.
We describe 9 nonimmunosuppressed patients with central nervous system cryptococcosis. Morbidity and mortality were high, especially among patients with cerebral infarcts. This was attributed to delayed diagnosis and apparent sequelae of overwhelming host immune responses. We present clues suggesting the diagnosis. Increased recognition and timely diagnosis of this condition may improve outcomes.
Ecevit
Ismail Zafer
IZ
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA.
Clancy
Cornelius J
CJ
Schmalfuss
Ilona M
IM
Nguyen
M Hong
MH
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000150:complications; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome
D000935:Antifungal Agents