[An association study between paranoid schizophrenia and four genes involved in dopamine metabolism].
Schizophrenia is a complex disease caused by interactions among multiple genes. Reports of one of its susceptibility genes, ethyltracatechol-O-mnsferase (COMT) have been conflicting. In the present study on paranoid schizophrenia, we have performed a multilocus association study to analyze the interactions among 4 genes that are involved in dopamine metabolism. Result supports the hypothesis that COMT-136-BclI regulates Val108/158Met. When the genotype of the former is CC, Met (A) is the genotype of susceptibility allele Val108/158Met; and when the genotype of the former is GG, Val (G) is the genotype of susceptibility allele Val108/158Met. This new hypothesis may explain the conflicting results about Val108/158Met (COMT) obtained by single-locus analyses. It also illustrates that multilocus analysis is necessary for the research of complex diseases.
Li
Jun-Ning
JN
The MOE Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing 100084, China. lijunning98@mails.tsinghua.edu.cn
Xu
Qi
Q
Shen
Yan
Y
Ji
Liang
L
D000328:Adult; D000483:Alleles; D001244:Association; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D004298:Dopamine / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005796:Genes; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D012563:Schizophrenia, Paranoid / Q000235:genetics*
D002394:Catechol O-Methyltransferase; D004298:Dopamine