Asymmetric synthesis of four isomers of 2-C-trifluoromethylerythritol.
Optically active 2-C-trifluoromethylerythritols, analogues of 2-C-methylerythritol, which is a key intermediate in the biosynthesis of isoprenoid with a mevalonate-independent route, were conveniently synthesized from 1,1,1-trifluoro-2,3-epoxypropane.
Wang
Hua
H
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China.
Zhao
Xiaoming
X
Li
Youhua
Y
Lu
Long
L
D004896:Erythritol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006900:Hydroxylation; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
C519212:2-C-trifluoromethylerythritol; D009930:Organic Chemicals; D004896:Erythritol