title: Efficacy of intramammary infusion of ceftiofur hydrochloride at drying off for treatment and prevention of bovine mastitis during the nonlactating period.
abstract: This study evaluated the efficacy of intramammary infusion of ceftiofur hydrochloride for the treatment of intramammary infections present at the last milking of lactation and for prevention of new intramammary infections during the nonlactating period. Cows were randomly assigned to five treatments (untreated negative control, 125, 250, and 500 mg of ceftiofur, and a positive control group receiving 300 mg cephapirin benzathine). A dose of 125 mg of ceftiofur per mammary quarter was effective for treatment of existing infections present at the time of milk cessation, but only the 500-mg dose of ceftiofur per mammary quarter was effective for both treatment of existing intramammary infections at the time of milk cessation and for prevention of new intramammary infections during the nonlactating period.
authors.affiliation: Pfizer Animal Health Veterinary Medicine Research and Development, 7000 Portage Road, Kalamazoo, MI 49001, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Hallberg
authors.forename: M
authors.initials: M
authors.lastname: Wachowski
authors.forename: W M
authors.initials: WM
authors.lastname: Moseley
authors.forename: K J
authors.initials: KJ
authors.lastname: Dame
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: S L
authors.initials: SL
authors.lastname: Wood
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D007267:Injections / Q000662:veterinary; D007774:Lactation / Q000502:physiology; D008321:Mammary Glands, Animal; D008414:Mastitis, Bovine / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C053503:ceftiofur