title: Hepatoprotective effect of extracts from Pergularia daemia Forsk.
abstract: Pergularia daemia (Asclepiadaceae) is a perennial herb growing widely along the road sides of India. It has been used in folk medicine for the treatment of liver disorders. The aim of this work is to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the aerial parts of Pergularia daemia. The aqueous and ethanolic extracts obtained from aerial parts of Pergularia daemia were evaluated for hepatoprotective activity in rats by inducing liver damage by carbon tetrachloride. The ethanolic extract at an oral dose of 200 mg/kg exhibited a significant (P<0.05) protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing the levels of total protein and albumin levels as compared to silymarin used as a positive control. These biochemical observations were supplemented by histopathological examination of liver sections. The activity may be a result of the presence of flavonoid compounds. Furthermore, the acute toxicity of the extracts showed no signs of toxicity up to a dose level of 2000 mg/kg. Thus it could be concluded that ethanolic extract of Pergularia daemia possesses significant hepatoprotective properties.
authors.affiliation: Pharmacy Department, Kalabhavan, The M.S. University of Baroda, Vadodara 390001, Gujarat, India. sureshsolleti@yahoo.co.in
authors.forename: S V
authors.initials: SV
authors.lastname: Sureshkumar
authors.forename: S H
authors.initials: SH
authors.lastname: Mishra
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D002251:Carbon Tetrachloride