Synthesis and photocytotoxic activity of new chlorin-polyamine conjugates.
This paper reports the synthesis of new chlorin-polyamine conjugates designed to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested against human chronic myelogenous leukemia cells (K562) and compared to the effects of Photofrin II and chlorin e6.
Garcia
Guillaume
G
Université de Limoges, Laboratoire de Chimie des Substances Naturelles, 123 Avenue Albert Thomas, F-87060 Limoges, France.
Sol
Vincent
V
Lamarche
François
F
Granet
Robert
R
Guilloton
Michel
M
Champavier
Yves
Y
Krausz
Pierre
P
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D011166:Porphyrins / Q000737:chemistry*
D017319:Photosensitizing Agents; D011073:Polyamines; D011166:Porphyrins; C006969:chlorin