A prospective study of early-pregnancy plasma malondialdehyde concentration and risk of preeclampsia.
OBJECTIVE
Preeclampsia is associated with elevated plasma malondialdehyde concentration, but prospective data are scarce. We examined the relation between early-pregnancy plasma malondialdehyde and subsequent preeclampsia risk.


METHODS
In a nested case-control analysis, we measured malondialdehyde concentrations in 22 women who developed preeclampsia and 711 who remained normotensive during pregnancy. We calculated adjusted odds ratios (OR) and 95% confidence intervals (CI). We repeated analyses after adjustment for early-pregnancy plasma lipid concentrations, which are related to preeclampsia risk and lipid peroxidation measures.


RESULTS
After adjustment for confounders, preeclampsia risk increased across tertiles of malondialdehyde concentration (trend P = 0.04). Further adjustment for triglyceride concentration slightly strengthened the association. Middle- and high-tertile malondialdehyde ORs were 3.2 (CI 0.8-12.2) and 4.2 (1.1-16.0) versus low-tertile exposure.


CONCLUSIONS
Early-pregnancy plasma malondialdehyde concentration is positively associated with subsequent preeclampsia risk independent of plasma lipid concentrations. These results support lipid peroxidation as an etiologic component of preeclampsia.
Rudra
Carole B
CB
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA. clb3@u.washington.edu
Qiu
Chunfang
C
David
Robert M
RM
Bralley
J Alexander
JA
Walsh
Scott W
SW
Williams
Michelle A
MA
D000328:Adult; D001835:Body Weight; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol