Membership in genetic groups predicts Alzheimer disease.
The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3:GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TT; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.
Corder
Elizabeth H
EH
Center for Demographic Studies, Duke University, Durham, North Carolina, USA.
Huang
Rong
R
Cathcart
Heather M
HM
Lanham
Irene S
IS
Parker
Ginny R
GR
Cheng
Danny
D
Smith
Suzanne
S
Poduslo
Shirley E
SE
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002402:Cathepsin D / Q000235:genetics; D055316:Cystatin C; D015891:Cystatins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics
D001057:Apolipoproteins E; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D011973:Receptors, LDL; D002402:Cathepsin D