title: Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.
abstract: Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM.
authors.affiliation: Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine and Public Health, 700 Children's Drive, W591, 43205, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Novotny
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Jurcisek
authors.forename: Fabrice
authors.initials: F
authors.lastname: Godfroid
authors.forename: Jan T
authors.initials: JT
authors.lastname: Poolman
authors.forename: Philippe A
authors.initials: PA
authors.lastname: Denoël
authors.forename: Lauren O
authors.initials: LO
authors.lastname: Bakaletz
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D002682:Chinchilla; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D007072:Immunoglobulin D / Q000276:immunology*; D008074:Lipoproteins / Q000276:immunology*; D009305:Nasopharynx / Q000382:microbiology; D010033:Otitis Media / Q000517:prevention & control*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D018073:Haemophilus Vaccines; D007106:Immune Sera; D007072:Immunoglobulin D; D008074:Lipoproteins; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; C067989:glpQ protein, Haemophilus influenzae