title: Molecular biology and physiology of the melanocortin system in fish: a review.
abstract: The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene (in particular adrenocorticotropic hormone, ACTH, and melanocyte-stimulating hormones, MSH) and five melanocortin receptor subtypes (MC1R-MC5R). Knowledge of the melanocortin system in fish is still limited, but information on the receptor part of the system is very rapidly growing. The melanocortin receptors (MCRs) have been recently cloned from several species of fish. The amino acid sequences appear remarkably well conserved. Pharmacological characterisation studies of the first identified piscine MCRs indicate that ACTH may be the original ligand for the MCRs, while the MSH peptides gained specialised functions in the course of evolution. Considering the tissue distribution of the MCRs, there are two distinctions between mammals and fish: where in mammals the MC4R is exclusively expressed in the central nervous system, in the fish species examined so far it is also peripherally expressed. It does however, alike the situation in mammals, likely play a key role in the central regulation of food intake and energy balance. Not only the MCRs, but also many other factors involved herewith, have been found in fish and roughly appear to function similarly as in mammals. The second difference is the distribution of the MC5R, which appears less widely expressed in fish than in mammals. Considering the available data it is predicted that, in mammals and fish alike, skin colouration is mediated via MC1R and steroidogenesis via MC2R. This review provides a short overview of the basic molecular characteristics, pharmacology, and tissue distribution of the MCRs in the fish investigated up to now, as well as their physiological role in the processes of skin colouration, steroidogenesis, and feeding behaviour.
authors.affiliation: Department Organismal Animal Physiology, Institute for Neuroscience, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
authors.forename: Juriaan R
authors.initials: JR
authors.lastname: Metz
authors.forename: Joris J M
authors.initials: JJ
authors.lastname: Peters
authors.forename: Gert
authors.initials: G
authors.lastname: Flik
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D005399:Fishes / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D008969:Molecular Sequence Data; D044101:Receptors, Melanocortin / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D000521:alpha-MSH / Q000235:genetics / Q000502:physiology*
chemical_list: D044101:Receptors, Melanocortin; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones