Paraadrenal Castleman disease presenting with adrenal hyperandrogenism.
Castleman disease, or angiofollicular lymph node hyperplasia, is a rare benign lymphoproliferative disorder. We report an uncommon case of retroperitoneal Castleman syndrome associated with adrenal hyperandrogenism and with interleukin-6 as the possible link in the pathophysiology of both disturbances. Four years after surgical resection of the paraadrenal mass, the patient is free of signs of recurrence of Castleman disease and adrenal hyperandrogenism.
Müssig
K
K
Division of Endocrinology, Metabolism and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tübingen, Tübingen, Germany. Karsten.Muessig@med.uni-tuebingen.de
Gallwitz
B
B
Machicao
F
F
Horger
M
M
Häring
H-U
HU
Kaiserling
E
E
D000311:Adrenal Glands / Q000378:metabolism / Q000473:pathology; D000328:Adult; D005871:Castleman Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology* / Q000378:metabolism; D007124:Immunoenzyme Techniques; D015850:Interleukin-6 / Q000378:metabolism; D012313:RNA / Q000302:isolation & purification; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D012313:RNA