title: Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.
abstract: BACKGROUND
  High frequency of Epstein-Barr virus (EBV) in the normal mucosa of the upper aerodigestive tract suggests that it may serve as a reservoir for the virus. Malignant lymphomas arising in this site may be associated with EBV.
  
  
  OBJECTIVE
  To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract.
  
  
  METHODS
  King Chulalongkorn Memorial Hospital, Thailand.
  
  
  METHODS
  Descriptive study.
  
  
  METHODS
  42 Thai patients who presented between 1998 and 2003.
  
  
  METHODS
  The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens.
  
  
  RESULTS
  The recruited subjects were 26 males and 16 females, and their age ranged from 3 to 85 years with the mean of 51.43 years, in 4 of them human immune deficiency virus (HIV) infection was documented. Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case). Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma).
  
  
  CONCLUSIONS
  In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma. It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.
authors.affiliation: Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Thamathorn.A@chula.ac.th
authors.forename: Thamathorn
authors.initials: T
authors.lastname: Assanasen
authors.forename: Pongsak
authors.initials: P
authors.lastname: Wannakrairot
authors.forename: Somboon
authors.initials: S
authors.lastname: Keelawat
authors.forename: Preecha
authors.initials: P
authors.lastname: Ruangvejvorachai
authors.forename: Nootchanat
authors.initials: N
authors.lastname: Pramprayoon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004197:Disease Reservoirs; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008223:Lymphoma / Q000503:physiopathology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000503:physiopathology / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012137:Respiratory System / Q000503:physiopathology / Q000821:virology*; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D041742:Upper Gastrointestinal Tract / Q000503:physiopathology / Q000821:virology*