Treatment of central pontine myelinolysis with thyrotropin-releasing hormone.
BACKGROUND
Central pontine myelinolysis (CPM), demyelination of the brain stem, is a brain injury apparently due to osmotic forces. There is no consensus for its treatment.


METHODS
We describe here a case of CPM that occurred in a young patient after correction of hyponatremia, its treatment by intravenous thyrotropin-releasing hormone, and its outcome.


CONCLUSIONS
Although very few instances of thyrotropin-releasing hormone treatment for CPM have been described, it appears to be effective and well tolerated. Studies are needed to assess its real efficacy.
Zein
Emile F
EF
Internal Medicine Department, Saint-Joseph Hospital and Medical Center, Saint-Joseph University, Beirut, Lebanon.
Karaa
Souheil E
SE
Rollot
Florence
F
Blanche
Philippe
P
Chemaly
Raymond E
RE
D000328:Adult; D006801:Humans; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000188:drug therapy* / Q000473:pathology*; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*; D016896:Treatment Outcome
D013973:Thyrotropin-Releasing Hormone