title: [Synthesis and toxicity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine].
abstract: In order to obtain new compounds with potential antibacterial activity some new (sulfonamidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta2-oxazolinone with various sulfonamides. A toxicity study with determination of DL50 value has also been realized.
authors.affiliation: Universitatea Al. I. Cuza Iaşi, Facultatea de Chimie.
authors.forename: V
authors.initials: V
authors.lastname: Sunel
authors.forename: Anca
authors.initials: A
authors.lastname: Ciobanu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
authors.forename: Cristina
authors.initials: C
authors.lastname: Băsu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000963:Antimetabolites / Q000138:chemical synthesis / Q000494:pharmacology; D001216:Asparagine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D023421:Models, Animal; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D013449:Sulfonamides; D001216:Asparagine