Unusual visualization of an adrenal carcinoma on NP-59 scintiscan.
[Iodine-131]6-beta-iodomethylnorcholesterol (NP-59) visualization of adrenocortical carcinoma is unusual. We describe a 17-year-old female with virilization and elevated plasma testosterone, dehydroepiandrosterone sulfate (DHEAS) and aldosterone. Magnetic resonance imaging disclosed a 9-cm right adrenal mass. NP-59 adrenal scanning displayed unilateral uptake of tracer and no visualization of the contralateral adrenal gland. Exploratory laparotomy revealed adrenocortical carcinoma. Subsequent immunohistochemical studies confirmed that the tumor was capable of producing a mixture of steroids, including testosterone, DHEAS and aldosterone. Visualization of an adrenal tumor on NP-59 scintiscan is an unusual finding, which cannot exclude the possibility of malignancy.
Wang
Fan-Fen
FF
Division of Endocrinology and Metabolism, Taipei Municipal Yang-Ming Hospital, Taipei, Taiwan.
Chang
Yen-Hwa
YH
Pan
Chin-Chen
CC
Tu
Dom-Gene
DG
Won
Justin Ging-Shing
JG
D000293:Adolescent; D000301:Adosterol; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D000450:Aldosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D000450:Aldosterone; D000301:Adosterol; D019314:Dehydroepiandrosterone Sulfate