title: Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila.
abstract: During asymmetric division, a cell polarizes and differentially distributes components to its opposite ends. The subsequent division differentially segregates the two component pools to the daughters, which thereby inherit different developmental directives. In Drosophila sensory organ precursor cells, the localization of Numb protein to the cell's anterior cortex is a key patterning event and is achieved by the combined action of many proteins, including Pins, which itself is localized anteriorly. Here, a role is described for the trimeric G protein Go in the anterior localization of Numb and daughter cell fate specification. Go is shown to interact with Pins. In addition to a role in recruiting Numb to an asymmetric location in the cell's cortex, Go transduces a signal from the Frizzled receptor that directs the position in which the complex forms. Thus, Go likely integrates the signaling that directs the formation of the complex with the signaling that directs where the complex forms.
authors.affiliation: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Suite 1120, New York, NY 10032, USA. at41@columbia.edu
authors.forename: Vladimir L
authors.initials: VL
authors.lastname: Katanaev
authors.forename: Andrew
authors.initials: A
authors.lastname: Tomlinson
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity; D004330:Drosophila / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051157:Frizzled Receptors / Q000378:metabolism; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007605:Juvenile Hormones / Q000378:metabolism; D009154:Mutation; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D051157:Frizzled Receptors; D007605:Juvenile Hormones; D043562:Receptors, G-Protein-Coupled; C058784:fz protein, Drosophila; C060606:numb protein, Drosophila; D019206:GTP-Binding Protein alpha Subunits, Gi-Go