PPAR-gamma: a thrifty transcription factor.
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.
Auwerx
Johan
J
Institut de Genetique et Biologie Moleculaire et Cellulaire (IGBMC) and and Institut Clinique de la Souris (ICS), 67404 Illkirch, France. auwerx@igbmc.u-strasbg.fr
Cock
Terrie-Ann
TA
Knouff
Chris
C