title: Deep neck infection as the main initial presentation of primary head and neck cancer.
abstract: OBJECTIVE
  Primary head and neck cancer and deep neck infection are not uncommon, but deep neck infection as the initial presentation of primary head and neck cancer is rare and these patients risk potential misdiagnosis.
  
  
  METHODS
  The records of 301 patients with deep neck infection and 3,337 patients with primary head and neck cancers from 1990 to 2002 were retrospectively reviewed. Patients with primary head and neck cancers who had deep neck infection as their initial presentation were enrolled.
  
  
  RESULTS
  Seven patients were identified (six men and one woman). The median age was 64 years. All patients presented with painful, erythematous neck swelling and all image studies showed abscess formation. Four abscesses received needle aspiration and three received surgical drainage, which yielded malignant cells in four specimens. The primary origins of malignancies were the nasopharynx (two patients), oropharynx (two patients), hypopharynx (one patient), parotid gland (one patient) and maxillary sinus (one patient). All patients had stage IV disease. Only three patients could receive curative therapy and only one patient was disease-free after three years.
  
  
  CONCLUSIONS
  We suggest that detailed history-taking, complete examination of the ENT field and pathological study of the infected tissue must be performed for patients with deep neck infection to enable early detection and prompt treatment of any underlying malignancy.
authors.affiliation: Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Wang
authors.forename: Jenq-Yuh
authors.initials: JY
authors.lastname: Ko
authors.forename: Pei-Jen
authors.initials: PJ
authors.lastname: Lou
mesh_terms: D000038:Abscess / Q000150:complications / Q000628:therapy; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary; D006801:Humans; D007239:Infections / Q000150:complications* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008441:Maxillary Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary; D008875:Middle Aged; D009333:Neck; D010307:Parotid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed