HBV genotypes and antiviral-resistant variants in HBV infected subjects in Northern Italy.
HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects.
Medici
Maria Cristina
MC
Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy. mariacristina.medici@unipr.it
Aloisi
Annalisa
A
Martinelli
Monica
M
Abelli
Laura Anna
LA
Casula
Francesca
F
Valcavi
Pierpaolo
P
Dettori
Giuseppe
G
Chezzi
Carlo
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy* / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D007558:Italy; D019259:Lamivudine / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D017422:Sequence Analysis, DNA
D004279:DNA, Viral; D019259:Lamivudine