title: Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice.
abstract: This study verifies the effects of bovine brain phosphatidylserine (PS) on passive avoidance (PA) and contextual fear conditioning (CFC) tests in scopolamine-treated mice. Mice received daily i.p. 50 mg/kg PS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. On day 6, mice received saline (TRIS-SAL and PS-SAL) or 1 mg/kg SCO (TRIS-SCO and PS-SCO) i.p. After 20 min, the animals were submitted to PA (experiment 1) or CFC (experiment 2) training sessions, and tests were performed 24 h later. Latency in entering the dark chamber of the PA apparatus presented by TRIS-SCO (but not PS-SCO) group in the test was significantly higher than those presented by controls. Except for TRIS-SCO, all the groups presented higher latencies in the test compared to the training session. In experiment 2, the TRIS-SCO (but not PS-SCO) group presented significantly lower freezing duration than that presented by the TRIS-SAL group in the test. Animals treated with PS alone presented higher freezing duration than that presented by the TRIS-SAL group. The results demonstrate that PS attenuates SCO-induced amnesia in both PA and CFC tests. In addition, PS per se improves retention in the CFC test.
authors.affiliation: Department of Pharmacology, Universidade Federal de São Paulo, R. Botucatu, 862-Ed Leal Prado, CEP 04023-062, São Paulo, SP, Brazil.
authors.forename: Flavia T
authors.initials: FT
authors.lastname: Claro
authors.forename: Camilla L
authors.initials: CL
authors.lastname: Patti
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Abílio
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: Regina H
authors.initials: RH
authors.lastname: Silva
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology*; D002417:Cattle; D003213:Conditioning, Psychological / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005239:Fear / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D018727:Muscarinic Antagonists / Q000633:toxicity*; D010718:Phosphatidylserines / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000633:toxicity*
chemical_list: D018727:Muscarinic Antagonists; D010718:Phosphatidylserines; D012601:Scopolamine