Resin-bound dynamic combinatorial chemistry.
[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.
McNaughton
Brian R
BR
Department of Chemistry, and The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.
Miller
Benjamin L
BL
D001483:Base Sequence; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry*
D011137:Polystyrenes; C101297:Tentagel resin; D004247:DNA