Modulation of macrophage function and metabolism.
Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.
Bellosta
S
S
Department of Pharmacological Sciences, University of Milan, Italy. Stefano.Bellosta@unimi.it
Bernini
F
F
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000819:agonists; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D000071518:Liver X Receptors; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D045726:Metalloproteases / Q000378:metabolism*; D057093:Orphan Nuclear Receptors; D047495:PPAR gamma / Q000819:agonists; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology; D013925:Thromboplastin / Q000235:genetics
D002121:Calcium Channel Blockers; D004268:DNA-Binding Proteins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear; D020845:Selective Estrogen Receptor Modulators; D013925:Thromboplastin; D002784:Cholesterol; D045726:Metalloproteases