title: Analysis of co-aggregation of cancer based on registry data.
abstract: OBJECTIVE
  An exploratory analysis of co-aggregation of cancers using registry-based data.
  
  
  METHODS
  We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment.
  
  
  RESULTS
  We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01).
  
  
  CONCLUSIONS
  This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.
authors.affiliation: Massachusetts General Hospital Biostatistics Center, Boston, MA 02114, USA.
authors.forename: Abigail G
authors.initials: AG
authors.lastname: Matthews
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Betensky
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.forename: Deborah
authors.initials: D
authors.lastname: Bowen
authors.forename: Constance
authors.initials: C
authors.lastname: Griffin
authors.forename: Claudine
authors.initials: C
authors.lastname: Isaacs
authors.forename: Carol
authors.initials: C
authors.lastname: Kasten
authors.forename: Geraldine
authors.initials: G
authors.lastname: Mineau
authors.forename: Susan
authors.initials: S
authors.lastname: Nayfield
authors.forename: Joellen
authors.initials: J
authors.lastname: Schildkraut
authors.forename: Louise
authors.initials: L
authors.lastname: Strong
authors.forename: Barbara
authors.initials: B
authors.lastname: Weber
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Finkelstein
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D012042:Registries