Insulin resistance in Brazilian adolescent girls: association with overweight and metabolic disorders.
We assessed the association between insulin resistance, overweight and metabolic disorders in a probabilistic sample of 388, 12-19-year-old girls from public schools in Niterói, Rio de Janeiro State, Brazil. Insulin resistance was determined using Homeostatic Model Assessment-Insulin Resistance (HOMA-IR). Overweight and obesity were defined by the sex- and age-specific body mass index cut-offs recommended by the International Obesity Task Force. Metabolic syndrome (MS) was identified by the presence of at least three of the following factors: fasting glucose >or=100mg/dL, triglycerides >130 mg/dL, LDL-C >or=110 mg/dL, HDL-C <35 mg/dL and overweight. The combined prevalence of obesity (2.9%) and overweight was 14.2%. The average HOMA-IR level was 2.24 (95% confidence interval=1.40-3.10) in the overweight group and 1.91 (95% CI=1.32-2.50) in the non-overweight one, and MS prevalence was 20 times higher in the first group (21.4 and 0.1%). MS prevalence in the overweight group was 6.3 times higher in adolescents above the 66th percentile of HOMA-IR (55.9%) than those under the 33rd percentile (8.9%). Brazilian overweight girls with higher insulin resistance had high risk of developing MS. Therefore, prevention should occur at an early age to impair the evolution of this process.
Alvarez
Marlene Merino
MM
Department of Nutrition, Universidade Federal do Rio de Janeiro, Instituto de Nutrição-CCS, Bloco J 2 andar, Av. Brigadeiro Trompowisky, s/n Ilha do Fundão, CEP 21941-590, Rio de Janeiro, RJ, Brazil. marlene.merino@globo.com <marlene.merino@globo.com>
Vieira
Ana Carolina Reiff E
AC
Moura
Aníbal Sanches
AS
da Veiga
Gloria Valeria
GV
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001938:Brazil; D002648:Child; D005260:Female; D006304:Health Status; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008659:Metabolic Diseases / Q000453:epidemiology / Q000503:physiopathology*; D050177:Overweight / Q000502:physiology*; D012574:Schools
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids