title: A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities.
abstract: A structurally characterized mixed-valent tetranuclear ruthenium-oxo oxalato cluster exhibits anti-viral activities toward R5- and X4-tropic HIV-1, and possesses cytoprotective activity toward HIV-1 infected cells.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Ella Lai-Ming
authors.initials: EL
authors.lastname: Wong
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Nancy P-Y
authors.initials: NP
authors.lastname: Chung
authors.forename: Chen-Lung Steve
authors.initials: CL
authors.lastname: Lin
authors.forename: Nianyong
authors.initials: N
authors.lastname: Zhu
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D020287:In Situ Nick-End Labeling; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010070:Oxalates / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D009942:Organometallic Compounds; D010070:Oxalates; D012428:Ruthenium; D054303:HIV Reverse Transcriptase