[Meta-analysis of the association of the LRP C766T polymorphism with the risk of Alzheimer's disease].
A C-to-T polymorphism in exon 3 of the low density lipoprotein receptor-related protein 1 (LPR-1) gene has been implicated as a risk factor for Alzheimer's disease (AD). The authors performed a meta-analysis to investigate the association between the C766T polymorphism in the LPR-1 gene and the risk for AD. Nineteen references were retrieved through Medline, Cochran Library and CBM search from 1997 to 2004. Similar search strategies were applied to each of these databases. Studies which were eligible for the meta-analysis should meet the following inclusion criteria: presentation of original data and a cross-sectional design, AD as the outcome of interest, an odds ratio (or enough information to calculate it) reported to quantify the association between the frequencies of genotypes and/or alleles of LPR-1 gene C766T polymorphism and the risk for AD. All analyses were performed with Review Manager 4.2. A total of 3,560 AD patients and 3,476 control subjects were analyzed according to the random effect model because some between-study heterogeneity was found (P<0.01). The combined data statistics revealed that there was no statistical difference (test for overall effect: Z=1.74, P=0.08, OR=1.17, 95% CI: 0.98-1.39; Z=1.31, P=0.19, OR=1.11, 95% CI: 0.95-1.31) in the frequencies of allele and genotype between the AD patients and the controls. The meta-analysis showed that the LPR-1 polymorphism was not a major risk factor for AD, although a small effect of the polymorphism for AD risk could not be excluded.
Deng
Ying
Y
West China Hospital, Sichuan University, Chengdu 610041, China. dengying03@126.com
Sun
Yan
Y
Shi
Jia-Jun
JJ
Zhang
Si-Zhong
SZ
D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D001244:Association; D003596:Cytosine; D020022:Genetic Predisposition to Disease; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D015201:Meta-Analysis as Topic; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013936:Thymidine
D026503:Low Density Lipoprotein Receptor-Related Protein-1; D003596:Cytosine; D013936:Thymidine