Discovery of the neutralizing epitope common to influenza B virus victoria group isolates in Japan.
Monoclonal antibody 9B2 possesses hemagglutination inhibition activity against all the 2002/2003 influenza B virus Victoria group isolates in Kobe, Japan, as well as representative strains isolated between 1987 and 1997. The 9B2 epitope localizes three-dimensionally in the vicinity of antigenic site A of the hemagglutinin molecule, and amino acid substitutions in this region affected the binding of 9B2.
Nakagawa
Naoko
N
Department of Microbiology, Kobe Institute of Health, 4-6, Minatojima-nakamachi, Chuo-ku, Kobe 650-0046, Japan. nknkgw@h2.dion.ne.jp
Suzuoki
Jun
J
Kubota
Ritsuko
R
Kobatake
Shinzo
S
Okuno
Yoshinobu
Y
D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D009981:Influenza B virus / Q000145:classification* / Q000276:immunology; D007564:Japan / Q000453:epidemiology; D009500:Neutralization Tests
D000939:Epitopes; D019267:Hemagglutinin Glycoproteins, Influenza Virus