title: [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate].
abstract: Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.
authors.affiliation: Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.
authors.forename: M
authors.initials: M
authors.lastname: Apostu
authors.forename: Nela
authors.initials: N
authors.lastname: Bibire
authors.forename: V
authors.initials: V
authors.lastname: Dorneanu
mesh_terms: D000897:Anti-Ulcer Agents / Q000032:analysis; D015738:Famotidine / Q000032:analysis* / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000032:analysis* / Q000627:therapeutic use; D006801:Humans; D007202:Indicators and Reagents; D010437:Peptic Ulcer / Q000188:drug therapy; D019999:Pharmaceutical Solutions / Q000032:analysis; D047069:Pyrazolones / Q000032:analysis* / Q000627:therapeutic use; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D047069:Pyrazolones; D015738:Famotidine; C010291:picrolonic acid