title: Some nuts are tougher to crack than others.
abstract: In this issue of Immunity, Oestreich et al. (2006) show that, during V(D)J recombination, RSSs may have distinct accessibility requirements. Some rely on an enhancer-intrinsic, general chromatin opening function, whereas others require enhancer-promoter interactions that direct local chromatin remodeling.
authors.affiliation: Department of Immunology, P.O. Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Krangel
authors.forename: Juan
authors.initials: J
authors.lastname: Carabana
authors.forename: Iratxe
authors.initials: I
authors.lastname: Abarrategui
mesh_terms: D000818:Animals; D000916:Antibody Diversity / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D019672:Genes, T-Cell Receptor / Q000235:genetics*; D006801:Humans; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics