An unusual presentation of anti-Jo-1 syndrome, mimicking lung metastases, with massive pleural and pericardial effusions.
We report a case of anti-Jo-1 syndrome (a rare autoimmune condition that may manifest with various forms of interstitial lung disease), which in our case presented unusually with multiple pulmonary nodules, mimicking carcinoma. She subsequently developed pleural and pericardial effusions (which are rare in this syndrome), myopathy, and "mechanic's hand," with similar lesions on the feet. "Mechanic's foot" noted in this patient has not been previously described. She initially responded well to immunosuppression but has subsequently progressed to pulmonary fibrosis.
Mogulkoc
Nesrin
N
Department of Chest Medicine, Ege University Medical Faculty, Bornova, 35100 Izmir, Turkey. nmogulkoc@compuserve.com
Kabasakal
Yasemin
Y
Ekren
Pervin Korkmaz
PK
Bishop
Paul W
PW
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005533:Foot Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D005938:Glucocorticoids / Q000627:therapeutic use; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D010490:Pericardial Effusion / Q000188:drug therapy / Q000209:etiology*; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology*; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; C046750:Jo-1 antibody; D016572:Cyclosporine; D003520:Cyclophosphamide; D011241:Prednisone