Effect of millimeter waves on cyclophosphamide induced NF-kappaB.
Antiapoptotic activity of NF-Kappa B (NF-kappaB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-kappaB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-kappaB DNA-binding activity as compared to the control group. No significant enhancement in NF-kappaB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-kappaB induced by chemotherapeutic drugs.
Logani
M K
MK
Richard J. Fox Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA. mlogani@temple.edu
Natarajan
M
M
Makar
V R
VR
Bhanushali
A
A
Ziskin
M C
MC
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000494:pharmacology* / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000528:radiation effects*; D009369:Neoplasms / Q000188:drug therapy; D011846:Radio Waves / Q000009:adverse effects*; D013154:Spleen / Q000378:metabolism
D018906:Antineoplastic Agents, Alkylating; D016328:NF-kappa B; D003520:Cyclophosphamide; D004247:DNA