Symptom dimensions in obsessive-compulsive disorder: prediction of cognitive-behavior therapy outcome.
OBJECTIVE
A significant number of patients with obsessive-compulsive disorder (OCD) fail to benefit sufficiently from treatments. This study aimed to evaluate whether certain OCD symptom dimensions were associated with cognitive-behavioral therapy (CBT) outcome.


METHODS
Symptoms of 104 CBT-treated in-patients with OCD were assessed with the clinician-rated Yale-Brown Obsessive-Compulsive Scale symptom checklist. Logistic regression analyses examined outcome predictors.


RESULTS
The most frequent OCD symptoms were aggressive and contamination obsessions, and compulsive checking and cleaning. Patients with hoarding symptoms at baseline (n = 19) were significantly less likely to become treatment responders as compared to patients without these symptoms. Patients with sexual and religious obsessions tended to respond less frequently, although this failed to reach statistical significance (P = 0.07). Regression analyses revealed that higher scores on the hoarding dimension were predictive of non-response, even after controlling for possible confounding variables.


CONCLUSIONS
Our results strongly indicate that in-patients with obsessive-compulsive hoarding respond poorly to CBT.
Rufer
M
M
Center of Psychosocial Medicine, Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany. michael.rufer@usz.ch
Fricke
S
S
Moritz
S
S
Kloss
M
M
Hand
I
I
D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007297:Inpatients / Q000523:psychology / Q000706:statistics & numerical data; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D011237:Predictive Value of Tests; D011581:Psychological Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome