title: Quantitative ultrasonometry of the calcaneus in children with juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To evaluate bone quality by means of quantitative ultrasonometry (QUS) in children with juvenile idiopathic arthritis (JIA).
  
  
  METHODS
  Seventy children [37 with oligoarticular JIA, mean age (+/-s.d.) 10.54 +/- 3.42 yr; and 33 with polyarticular rheumatoid factor negative JIA, mean age (+/- s.d.) 11.33 +/- 2.88 yr] were enrolled. Quantitative ultrasonometry was measured on both heels with a Cuba Clinical portable device. Body height, weight and body mass index were recorded together with disease duration and cumulative dose of prednisone.
  
  
  RESULTS
  The lowest QUS parameters were observed in children with polyarticular JIA (P< 0.001 and 0.01 when compared with reference data and oligoarticular JIA, respectively). In children with oligoarticular JIA, the QUS values were also significantly lower in comparison with the reference data (P< 0.002). The QUS parameters were strongly influenced by body height, and to a lesser degree by body weight. In children with polyarticular JIA, there were significant inverse correlations between QUS parameters and disease duration [r=-0.57, P< 0.01 for broadband ultrasound attenuation (BUA) and r = - 0.67, P< 0.01 for velocity of sound (VOS)]. Similarly, there were inverse correlations between QUS and cumulative dose of prednisone (r = - 0.48, P< 0.05 for BUA and r =- 0.50, P < 0.01 for VOS, respectively). Similar results were obtained when BUA and VOS were adjusted for height.
  
  
  CONCLUSIONS
  Disease duration and cumulative dose of prednisone in children with polyarticular JIA are risk factors of stunted growth and decreased QUS values of bone quality.
authors.affiliation: Center for Clinical and Basic Research (CCBR), Kyjevská 40, 530 03 Pardubice, Czech Republic. sk@ccbr.cz
authors.forename: S
authors.initials: S
authors.lastname: Kutilek
authors.forename: M
authors.initials: M
authors.lastname: Bayer
authors.forename: P
authors.initials: P
authors.lastname: Dolezalova
authors.forename: D
authors.initials: D
authors.lastname: Nemcova
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D001827:Body Height / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002111:Calcaneus / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006130:Growth Disorders / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D005938:Glucocorticoids; D011241:Prednisone