title: Amino alcohols as ligands for nickel-catalyzed suzuki reactions of unactivated alkyl halides, including secondary alkyl chlorides, with arylboronic acids.
abstract: Suzuki cross-coupling reactions of an unprecedented array of unactivated primary and secondary alkyl halides (including challenging alkyl chlorides) can be accomplished through the use of nickel/amino alcohol-based catalysts. Both the nickel precatalyst and the amino alcohols (prolinol or trans-2-aminocyclohexanol) are commercially available and air-stable. In view of the remarkable diversity of amino alcohols that are readily accessible, this discovery may open the door to the rapid development of versatile catalysts for a wide range of cross-coupling processes.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Francisco
authors.initials: F
authors.lastname: González-Bobes
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Fu
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D008024:Ligands; D009532:Nickel / Q000737:chemistry*
chemical_list: D000605:Amino Alcohols; D001897:Boronic Acids; D006219:Halogens; D008024:Ligands; D009532:Nickel