title: Structure-activity studies of oxazolidinone analogs as RNA-binding agents.
abstract: We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.
authors.affiliation: Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
authors.forename: John
authors.initials: J
authors.lastname: Means
authors.forename: Steven
authors.initials: S
authors.lastname: Katz
authors.forename: Abhijit
authors.initials: A
authors.lastname: Nayek
authors.forename: Rajaneesh
authors.initials: R
authors.lastname: Anupam
authors.forename: Jennifer V
authors.initials: JV
authors.lastname: Hines
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bergmeier
mesh_terms: D015195:Drug Design; D008024:Ligands; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D023303:Oxazolidinones; D012313:RNA