title: Modelling of proteins in membranes.
abstract: This review describes some recent theories and simulations of mesoscopic and microscopic models of lipid membranes with embedded or attached proteins. We summarize results supporting our understanding of phenomena for which the activities of proteins in membranes are expected to be significantly affected by the lipid environment. Theoretical predictions are pointed out, and compared to experimental findings, if available. Among others, the following phenomena are discussed: interactions of interfacially adsorbed peptides, pore-forming amphipathic peptides, adsorption of charged proteins onto oppositely charged lipid membranes, lipid-induced tilting of proteins embedded in lipid bilayers, protein-induced bilayer deformations, protein insertion and assembly, and lipid-controlled functioning of membrane proteins.
authors.affiliation: Biocentrum, The Technical University of Denmark, Lyngby.
authors.forename: Maria Maddalena
authors.initials: MM
authors.lastname: Sperotto
authors.forename: Sylvio
authors.initials: S
authors.lastname: May
authors.forename: Artur
authors.initials: A
authors.lastname: Baumgaertner
mesh_terms: D000327:Adsorption; D001665:Binding Sites; D003198:Computer Simulation; D004548:Elasticity; D057927:Hydrophobic and Hydrophilic Interactions; D007473:Ion Channels / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D009010:Monte Carlo Method; D016012:Poisson Distribution; D011487:Protein Conformation
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins