In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias.
The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.
Di Lazzaro
V
V
Institute of Neurology, Università Cattolica, Rome, Italy. vdilazzaro@rm.unicatt.it
Pilato
F
F
Dileone
M
M
Saturno
E
E
Oliviero
A
A
Marra
C
C
Daniele
A
A
Ranieri
F
F
Gainotti
G
G
Tonali
P A
PA
D000344:Afferent Pathways / Q000503:physiopathology*; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004594:Electrophysiology / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D013702:Temporal Lobe / Q000503:physiopathology*
D002800:Cholinesterase Inhibitors