title: Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease.
abstract: Changes in the levels of malondialdehyde (MDA), nitrate and nitrite (as an index of nitric oxide production), lipid hydroperoxide (LOH), total antioxidant capacity (TAC), lipids (total cholesterol and triglycerides) and lipoproteins (HDL- and LDL-cholesterol) were estimated in breast cancer patients (n = 15) and benign breast disease (n = 15). Serum and tissue MDA levels were found to be decreased in breast cancer patients compared to the benign group (p < 0.05). In contrast, nitrate and nitrite levels were increased in serum and tissue of the cancer group compared to benign breast disease patients (p < 0.05). Compared to the benign group, tissue TAC levels were elevated in the breast cancer patient group (p < 0.05). Total cholesterol and HDL-cholesterol were elevated in the benign group compared with cancer patients (p < 0.05). These findings support the hypothesis that lipid peroxidation in serum and tissue of benign breast disease is greater than in breast cancer. However, the enhanced levels of nitric oxide may be in response to inflammation in patients with breast cancer. Total antioxidant status is lower in benign tissue than in cancerous tissue, probably to compensate for this elevated free radical production.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey. aymelek@gazi.edu.tr
authors.forename: Aymelek
authors.initials: A
authors.lastname: Gönenç
authors.forename: Derya
authors.initials: D
authors.lastname: Erten
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Aslan
authors.forename: Melih
authors.initials: M
authors.lastname: Akinci
authors.forename: Bolkan
authors.initials: B
authors.lastname: Simşek
authors.forename: Meral
authors.initials: M
authors.lastname: Torun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001940:Breast / Q000378:metabolism* / Q000473:pathology*; D001943:Breast Neoplasms / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009566:Nitrates; D009573:Nitrites; D008315:Malondialdehyde