Failure to eradicate HIV despite fully successful HAART initiated in the first days of life.
Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
Viganò
Alessandra
A
Department of Paediatrics, University of Milan, Italy.
Trabattoni
Daria
D
Schneider
Laura
L
Ottaviani
Francesco
F
Aliffi
Antonia
A
Longhi
Erika
E
Rusconi
Stefano
S
Clerici
Mario
M
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000378:metabolism; D014766:Viremia / Q000821:virology; D014779:Virus Replication
D015483:HIV Antibodies; D007376:Interleukin-2; D007371:Interferon-gamma