[Analysis of auditory steady-state response to multiple simultaneous stimuli and cochlea morphology in guinea pigs with posterior semicircular canal fistula].
OBJECTIVE
To observe the changes of auditory steady-state response (ASSR) threshold in guinea pigs with posterior semicircular canal fistula.


METHODS
In 10 guinea pigs, a window was opened in the posterior semicircular canal of the left ear with the right ear serving as the control for testing the ASSR under anesthesia with pentobarbital sodium.


RESULTS
The mean and standard deviation of ASSR threshold (dB SPL) at 0.5, 1, 2, and 4 kHz in the left ear was 35.00+/-14.33, 25.50+/-12.37, 20.00+/-9.37 and 20.00+/-9.18, respectively, and was 31.00+/-16.19, 25.50+/-12.34, 18.00+/-6.96 and 18.50+/-6.71 in the right ear, respectively. Paired-sample t test showed no significant difference in the ASSR at the same frequency between the two ears.


CONCLUSIONS
Small fistula by surgery causes no significant hearing loss in guinea pigs.
Xie
Nan-ping
NP
Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xienp@fimmu.com
Chen
Guo-qiang
GQ
Yang
Xing
X
Shu
Si-yun
SY
D000818:Animals; D001301:Audiometry, Pure-Tone / Q000379:methods; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000473:pathology*; D005072:Evoked Potentials, Auditory; D005402:Fistula / Q000473:pathology / Q000503:physiopathology*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000473:pathology / Q000503:physiopathology*; D012665:Semicircular Canals