Hyperosmolality: another indication for hemodialysis following acute ethylene glycol poisoning.
When given early, fomepizole has demonstrated an effective role in the treatment of ethylene glycol (EG) intoxication, often eliminating the need for hemodialysis (HD). Many indications for HD have been suggested for EG intoxication. We present a case of EG intoxication with the second highest reported EG concentration. Despite early treatment with fomepizole and without the development of acidosis or renal insufficiency, the patient required HD for hyperosmolality and subsequent electrolyte imbalances. Indications for HD following EG intoxication are discussed.
Pizon
Anthony F
AF
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA. Anthony.Pizon@BannerHealth.com
Brooks
Daniel E
DE
D000137:Acid-Base Imbalance / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use; D019855:Ethylene Glycol / Q000097:blood / Q000506:poisoning*; D005260:Female; D000077604:Fomepizole; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D011041:Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use; D006435:Renal Dialysis
D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D019855:Ethylene Glycol