title: Lessons learned from Myc/Max/Mad knockout mice.
abstract: The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely those in which the N-myc, c-myc, L-myc, mad1, mxi1, mad3, mnt, or max genes have been targeted. A compilation of lessons we have learned from these myc/max/mad knockout mouse models, and suggestions as to where future efforts could be focused, are also presented.
authors.affiliation: Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 809, Bronx, NY 10461, USA.
authors.forename: M
authors.initials: M
authors.lastname: Pirity
authors.forename: J K
authors.initials: JK
authors.lastname: Blanck
authors.forename: N
authors.initials: N
authors.lastname: Schreiber-Agus
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D047108:Embryonic Development; D005260:Female; D016259:Genes, myc; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis; D009369:Neoplasms / Q000209:etiology; D010641:Phenotype; D011247:Pregnancy; D016271:Proto-Oncogene Proteins c-myc / Q000172:deficiency* / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C499479:Mad protein, mouse; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; C068422:Max protein, mouse