title: Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.
abstract: We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.
authors.affiliation: Molecular Virology Laboratory, University of Washington, 960 Republican St., Seattle, WA 98195, USA.
authors.forename: Todd
authors.initials: T
authors.lastname: Czartoski
authors.forename: Charlie
authors.initials: C
authors.lastname: Liu
authors.forename: David M
authors.initials: DM
authors.lastname: Koelle
authors.forename: Stephen
authors.initials: S
authors.lastname: Schmechel
authors.forename: Andrea
authors.initials: A
authors.lastname: Kalus
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D024882:Drug Resistance, Viral; D005260:Female; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000209:etiology*; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D017211:Treatment Failure
chemical_list: D000212:Acyclovir