Linezolid and human polymorphonuclear leukocyte function.
BACKGROUND
To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function.


METHODS
Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid.


RESULTS
Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst.


CONCLUSIONS
Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.
Naess
Are
A
Institute of Medicine, University of Bergen, Norway. are.nass@med.uib.no
Stenhaug Kilhus
Kristin
K
Nystad
Tone W
TW
Sørnes
Steinar
S
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005434:Flow Cytometry; D006801:Humans; D000069349:Linezolid; D009504:Neutrophils / Q000502:physiology*; D023303:Oxazolidinones / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D016897:Respiratory Burst / Q000187:drug effects*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid