title: Evaluation of povidone-iodine as a disinfectant solution for contact lenses: antimicrobial activity and cytotoxicity for corneal epithelial cells.
abstract: Povidone-iodine (PVP-I) possesses broad-spectrum antimicrobial activity and is used clinically as a disinfectant. We evaluated the disinfectant properties and safety of PVP-I for use as a contact lens solution. The concentrations of PVP-I required to reduce the number of Staphylococcus aureus or Candida albicans by 3 log units were lower than were those of hydrogen peroxide, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BAK). The cytotoxicity of PVP-I for cultured human corneal epithelial (HCE) cells was less than that of the other three agents. The safety margin for PVP-I was thus greatest among the tested compounds. PVP-I appears suited for use as a contact lens disinfectant.
authors.affiliation: Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. yanai@yamaguchi-u.ac.jp
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yanai
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamada
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ueda
authors.forename: Motoharu
authors.initials: M
authors.lastname: Tajiri
authors.forename: Toru
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Kido
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakamura
authors.forename: Fumio
authors.initials: F
authors.lastname: Saito
authors.forename: Teruo
authors.initials: T
authors.lastname: Nishida
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002478:Cells, Cultured; D015169:Colony Count, Microbial; D018639:Contact Lens Solutions / Q000494:pharmacology*; D003261:Contact Lenses / Q000382:microbiology*; D019573:Epithelium, Corneal / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D011206:Povidone-Iodine / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000891:Anti-Infective Agents, Local; D018639:Contact Lens Solutions; D011206:Povidone-Iodine