Enantioselective synthesis mediated by chiral crystal of achiral hippuric acid in conjunction with asymmetric autocatalysis.
Enantiomorphous crystals composed of achiral hippuric acid, i.e., naturally occurring N-benzoylglycine, have been used successfully as chiral inducers in enantioselective synthesis in combination with asymmetric autocatalysis to afford the product with extremely high enantiomeric excess.
Kawasaki
Tsuneomi
T
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Suzuki
Kenta
K
Hatase
Kunihiko
K
Otsuka
Masanari
M
Koshima
Hideko
H
Soai
Kenso
K
D002384:Catalysis; D002942:Circular Dichroism; D003460:Crystallization; D006626:Hippurates / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D006626:Hippurates; C030514:hippuric acid