Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone.
We present 2 cases of Cushing syndrome with secondary adrenal insufficiency from concomitant use of ritonavir and inhaled corticosteroids in children with human immunodeficiency virus infection. These cases highlight the need for special consideration when treatment with an inhaled/intranasal corticosteroid is indicated in children receiving antiretroviral therapy.
Johnson
Susan R
SR
Division of Infectious Diseases, Department of Pediatrics, University of South Florida College of Medicine, Tampa, 33606, USA. sjohnso2@hsc.usf.edu
Marion
Alicia A
AA
Vrchoticky
Teri
T
Emmanuel
Patricia J
PJ
Lujan-Zilbermann
Jorge
J
D000280:Administration, Inhalation; D000293:Adolescent; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003480:Cushing Syndrome / Q000139:chemically induced*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D000068298:Fluticasone; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019438:Ritonavir / Q000008:administration & dosage / Q000009:adverse effects*; D000068299:Salmeterol Xinafoate
D000730:Androstadienes; D001993:Bronchodilator Agents; D017320:HIV Protease Inhibitors; D000068299:Salmeterol Xinafoate; D000068298:Fluticasone; D019438:Ritonavir; D000420:Albuterol