title: [A study of correlation between the blood supply types of PHcc on spiral CT and the level of VEGF expression in PHcc].
abstract: OBJECTIVE
  To study the correlation between the blood supply types of primary hepatocellar carcinoma (PHcc) on Spiral CT and the level of vascular endothelial growth factor (VEGF) expression in PHcc for improvement in treatment strategies and prognostication.
  
  
  METHODS
  Forty-five cases of PHcc identified by operation and pathology were investigated. Immunohistochemistry staining in SP was performed. The relationships between blood supply types of PHcc on Spiral CT during dual-phase scanning and the expression levels of VEGF in well-differentiated, moderately differentiated and poorly differentiated PHcc were analyzed.
  
  
  RESULTS
  There were four blood supply types of PHcc on Spiral CT. Both the strong positive staining and the positive staining were most frequently seen in the hepatic artery blood supply type, and then were frequently in the double blood supply type, i. e. the hepatic arterial supply combining with the portal blood supply type. The positive staining results were rarely seen in the portal blood supply type and poor blood supply type (P<0.001). And with the escalation of the Edmonson- Steiner histological grades, the VEGF expression levels were shown to increase correspondingly (P < 0.05).
  
  
  CONCLUSIONS
  We can ascertain the blood supply type of PHcc and infer the VEGF expression levels that reflect the PHcc angiogenesis condition and the histological grades by means of Spiral CT during dual- phase scanning. Hence this method is useful for the selection of PHcc treatment plans, including anti-angiogenesis and evaluating the prognosis.
authors.affiliation: China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yun-chuan
authors.initials: YC
authors.lastname: Xie
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Zhou
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhou
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Rong-Bo
authors.initials: RB
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Chen
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Deng
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D036542:Tomography, Spiral Computed; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D042461:Vascular Endothelial Growth Factor A