title: Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination Antibiogram.
abstract: To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections based on the 2 antibiograms did not differ substantively. Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA.
authors.forename: Mari
authors.initials: M
authors.lastname: Mizuta
authors.forename: Darren R
authors.initials: DR
authors.lastname: Linkin
authors.forename: Irving
authors.initials: I
authors.lastname: Nachamkin
authors.forename: Neil O
authors.initials: NO
authors.lastname: Fishman
authors.forename: Mark G
authors.initials: MG
authors.lastname: Weiner
authors.forename: Angela
authors.initials: A
authors.lastname: Sheridan
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
mesh_terms: D000900:Anti-Bacterial Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests; D015143:Philadelphia; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents