Levels of P34H, a sperm protein of epididymal origin, as a predictor of conventional in vitro fertilization outcome.
A prospective double-blind study was performed to determine if Western blot detection of P34H, a sperm protein of epididymal origin that is involved in the binding to the zona pellucida, is predictive of standard IVF outcome. Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001).
Sullivan
Robert
R
Centre de Recherche en Biologie de la Reproduction, Département d'Obstétrique Gynécologie, Faculté de Médecine, Université Laval, Ste-Foy, Québec, Canada. robert.sullivan@crchul.ulaval.ca
Légaré
Christine
C
Villeneuve
Marc
M
Foliguet
Bernard
B
Bissonnette
François
F
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro; D005602:France / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D011792:Quebec / Q000453:epidemiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013401:Sugar Alcohol Dehydrogenases; D016896:Treatment Outcome
D015415:Biomarkers; D011506:Proteins; D013401:Sugar Alcohol Dehydrogenases; C023300:L-xylulose reductase