title: Synthesis and photocytotoxic activity of new chlorin-polyamine conjugates.
abstract: This paper reports the synthesis of new chlorin-polyamine conjugates designed to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested against human chronic myelogenous leukemia cells (K562) and compared to the effects of Photofrin II and chlorin e6.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, 123 Avenue Albert Thomas, F-87060 Limoges, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Garcia
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
authors.forename: François
authors.initials: F
authors.lastname: Lamarche
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.forename: Michel
authors.initials: M
authors.lastname: Guilloton
authors.forename: Yves
authors.initials: Y
authors.lastname: Champavier
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D011073:Polyamines; D011166:Porphyrins; C006969:chlorin