title: [Survey of plasma lipid value in children in Beijing area and the changes of gaseous molecule-hydrogen sulfide in the ones with dyslipidemia].
abstract: OBJECTIVE
  To evaluate plasma lipid value in children in Beijing areas and to explore the relationship between plasma hydrogen sulfide (H(2)S) level and lipid components.
  
  
  METHODS
  A total of 971 healthy school students were chosen randomly, all coming from Beijing city and its counties. They were divided into four groups according to their gender and age (boys and girls in school age and in puberty). Body mass index (BMI) was calculated according to the measurement of body height and weight. Familial history, past medical history and the history of present illness were investigated. Physical examination was also carried on. Alanine aminotransferase (ALT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were detected by HITACHI 7060 automatic biochemical analyzer. Forty children (31 males and 9 females) with dyslipidemia were chosen randomly among them as patients. Other 60 children (38 males and 22 females) with normal plasma lipid level served as controls. Plasma H(2)S level was detected by modified sulfide electrode.
  
  
  RESULTS
  There were 91 children with dyslipidemia (58 males and 33 females) in 971 students. The prevalence rate was 9.37%. The average value of BMI in patients was higher than that of controls. An association of increased ALT level with the prevalence of dyslipidemia was observed. Hydrogen sulfide concentration in plasma showed out skew distribution. Measurement data were presented as median (P(25), P(75)). Hydrogen sulfide was 34.40 (32.98, 35.47) micromol/L in children with dyslipidemia and 38.81(36.53, 40.66) micromol/L in controls. There was statistical difference between the two groups (P<0.01). Average value of plasma hydrogen sulfide was 35.54 (33.41, 39.24) micromol/L in males and 37.82 (33.84, 39.80) micromol/L in females. There was no difference in plasma hydrogen sulfide between male and female subjects (P>0.05).
  
  
  CONCLUSIONS
  The prevalence rate of dyslipidemia in Beijing children is relatively high as compared with what it was during the past several decades. There was a significant decrease in plasma endogenous H(2)S level in children with dyslipidemia as compared with that of healthy children. There was an obvious correlation between plasma hydrogen sulfide and plasma lipids.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Mi
authors.forename: Ya-guang
authors.initials: YG
authors.lastname: Ding
authors.forename: Jun-bao
authors.initials: JB
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D015995:Prevalence; D012307:Risk Factors
chemical_list: D008055:Lipids; D000410:Alanine Transaminase; D006862:Hydrogen Sulfide