title: Incidence of pituitary tumors in the human population of Croatia.
abstract: Pituitary tumors are rare tumors (less then 10%) of the central nervous system (CNS), which malignicity depends on their localization, meanwhile, their biological nature is benign. The diameter they have is mostly less then 10 mm (microadenomas), but sometimes could be 10 mm (macroadenomas) to 5 cm and more and then are usually nonfunctional (about 20% of all pituitary tumors). Clinical presence depends on their localisation and hormonal activity. In the Center for Clinical Neuroendocrinology and Pituitary Diseases, in the last working 10 years, there were treated and examined 504 patients from Croatia, all with pituitary tumors: 182 patients with prolactinomas, 137 with acromegaly, 70 with Morbus Cushing (Mb. Cushing), and 115 patients with nonfunctional pituitary tumors. The patient's classification is based on regional (Mediterranean and continental region, 20 counties) and the state level. In our analysis we haven't found difference in incidence of tumors between Mediterranean and continental region.
authors.affiliation: Center for Clinical Neuroendocrinology and Pituitary Diseases, Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital "Sestre milosrdnice", University of Zagreb, Zagreb, Croatia. vrkljan@kbsm.hr
authors.forename: Milan
authors.initials: M
authors.lastname: Vrkljan
authors.forename: Martina
authors.initials: M
authors.lastname: Matovinović
authors.forename: Andreja
authors.initials: A
authors.lastname: Marić
authors.forename: Marijo
authors.initials: M
authors.lastname: Bekić
authors.forename: Tajana
authors.initials: T
authors.lastname: Zah
authors.forename: Josip
authors.initials: J
authors.lastname: Resetić
authors.forename: Branka
authors.initials: B
authors.lastname: Vizner
authors.forename: Hrvoje Ivan
authors.initials: HI
authors.lastname: Pećina
authors.forename: Vatroslav
authors.initials: V
authors.lastname: Cerina
authors.forename: Zivko
authors.initials: Z
authors.lastname: Gnjidić
mesh_terms: D000172:Acromegaly / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D002648:Child; D017523:Croatia / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000453:epidemiology; D010911:Pituitary Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000473:pathology; D015175:Prolactinoma / Q000453:epidemiology*