Turning off neurotransmitters.
The historic discovery that the catecholamine neurotransmitters of the sympathetic nervous system, norepinephrine and epinephrine, are inactivated through their reuptake by presynaptic nerve terminals provided new insights into neurotransmitter action and paved the way for the development of modern antidepressant drugs.
Snyder
Solomon H
SH
Department of Neuroscience, Johns Hopkins University, 725 N. Wolfe Street, WBSB 813 Baltimore, MD 21205, USA. ssnyder@jhmi.edu
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology; D049673:History, 20th Century; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors* / Q000266:history* / Q000378:metabolism; D009613:Nobel Prize; D009638:Norepinephrine / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine