title: A common genetic variant is associated with adult and childhood obesity.
abstract: Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
authors.affiliation: Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA. aherbert@bu.edu
authors.forename: Alan
authors.initials: A
authors.lastname: Herbert
authors.forename: Norman P
authors.initials: NP
authors.lastname: Gerry
authors.forename: Matthew B
authors.initials: MB
authors.lastname: McQueen
authors.forename: Iris M
authors.initials: IM
authors.lastname: Heid
authors.forename: Arne
authors.initials: A
authors.lastname: Pfeufer
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: David
authors.initials: D
authors.lastname: Hunter
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Graham
authors.initials: G
authors.lastname: Colditz
authors.forename: Anke
authors.initials: A
authors.lastname: Hinney
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Kerstin
authors.initials: K
authors.lastname: Koberwitz
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Richard
authors.initials: R
authors.lastname: Cooper
authors.forename: Kristin
authors.initials: K
authors.lastname: Ardlie
authors.forename: Helen
authors.initials: H
authors.lastname: Lyon
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
authors.forename: Nan M
authors.initials: NM
authors.lastname: Laird
authors.forename: Marc E
authors.initials: ME
authors.lastname: Lenburg
authors.forename: Christoph
authors.initials: C
authors.lastname: Lange
authors.forename: Michael F
authors.initials: MF
authors.lastname: Christman
mesh_terms: D000328:Adult; D001741:Black or African American; D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D005060:Europe; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins