A comparative study regarding the morphological alteration on the gastric level after the administration of piroxicam and complexes with bio-ions Cu(II), Co(II), Zn(II) to rats.
The complex combinations of Piroxicam (Pirox) with the metallic bio-ions: Cu(II), Co(II), Zn(II) have been obtained and defined in a previous stage by physical-chemical methods (IR, X, SM, CSS-UV, DTA, DTG), an toxicological and biochemical aspect. In this research are presented the results of the histological examinations at the level of stomach, for each compound, at 24 hours and at 7 days after the administration of the Piroxicam and of its complexes to rats. The tissues histo-pathological investigation has pointed out lesions the glandular stomach level (necrosis, ulcers) especially after the administration of the Piroxicam and of the Zn-Pirox complex. Name of these have been present after the administration of Cu-Pirox, Co-Pirox.
Miere
Doina
D
Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, School of Pharmacy.
Filip
Lorena
L
Baba
I
I
Botoc
Mariana
M
Curea
Elena
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003035:Cobalt / Q000008:administration & dosage / Q000009:adverse effects*; D003300:Copper / Q000008:administration & dosage / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D023421:Models, Animal; D009336:Necrosis / Q000139:chemically induced; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D003035:Cobalt; D003300:Copper; D015032:Zinc