title: Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experience.
abstract: OBJECTIVE
  To determine the presentation, pathologic features, treatment outcome, and prognosis of mucoepidermoid carcinoma of the parotid gland in children.
  
  
  METHODS
  Retrospective clinical and histopathologic study with institutional review board approval.
  
  
  METHODS
  Tertiary pediatric medical center.
  
  
  METHODS
  Seven children (4 girls and 3 boys) presented with mucoepidermoid carcinoma of the parotid gland between 1994 and 2004.
  
  
  METHODS
  Clinical presentation, pathologic features, treatment outcome, complications, local recurrence, distant metastasis, and overall survival.
  
  
  RESULTS
  All patients presented with an asymptomatic parotid mass. Initial treatment in 7 patients included total parotidectomy (n = 3), superficial parotidectomy (n = 3), transoral enucleation (n = 1), and supraomohyoid neck dissection (n = 1). Four patients required additional surgical procedures because of a close and/or positive margin, including revision parotidectomy (n = 2), total parotidectomy (n = 1), superficial parotidectomy (n = 1), and supraomohyoid neck dissection (n = 1). One patient required postoperative radiation therapy. No evidence of local recurrence or distant metastasis was noted with a mean follow-up of 3.4 years.
  
  
  CONCLUSIONS
  Mucoepidermoid carcinoma of the parotid gland is very rare in children. Clinical stage and histologic grade are the main prognostic factors. Complete excision (superficial or total parotidectomy) with preservation of facial nerve is the treatment of choice. Neck dissection should be considered when there is clinical evidence of regional metastasis, high TNM stage, high histologic grade, and involvement of regional nodes. Because of the possibility of long-term adverse effects in pediatric patients, radiotherapy should be used only in selected cases. Long-term follow-up is essential to rule out late recurrence.
authors.affiliation: Department of Otolaryngology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. reza.rahbar@childrens.harvard.edu
authors.forename: Reza
authors.initials: R
authors.lastname: Rahbar
authors.forename: J Fredrik
authors.initials: JF
authors.lastname: Grimmer
authors.forename: Sara O
authors.initials: SO
authors.lastname: Vargas
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Robson
authors.forename: Jennifer W
authors.initials: JW
authors.lastname: Mack
authors.forename: Antonio R
authors.initials: AR
authors.lastname: Perez-Atayde
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Marcus
authors.forename: Holcombe E
authors.initials: HE
authors.lastname: Grier
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Healy
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: McGill
mesh_terms: D000293:Adolescent; D001900:Boston / Q000453:epidemiology; D018277:Carcinoma, Mucoepidermoid / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010307:Parotid Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed