title: HIV-related nephropathy: a South African perspective.
abstract: Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) is an important cause of renal failure in those of African origin. A number of other kidney diseases occur in HIV-positive patients. We conducted a retrospective review of renal biopsies in HIV-positive Black African patients to determine the prevalence of both 'classic HIVAN' and non-HIVAN pathologies in this group. Clinical and laboratory data from HIV-positive patients who underwent renal biopsy from 1st January 2003 to 31st December 2004 were collected. Similar information on HIV-negative patients biopsied during the same period was also recorded by way of comparison to try and assess the influence of the virus on renal histologic patterns. HIV-positive group - 99 biopsies were suitable for study. The main histologic categories were 'classic HIVAN' (27%) and HIV immune complex kidney disease ('HIVICK') (21%). The subepithelial immune deposits in 'HIVICK' induced a newly described 'ball-in-cup' basement membrane reaction. Other glomerulonephritides included membranous, post-infectious disease, mesangial hyperplasia, and immunoglobulin A nephropathy. Overlapping clinical presentations prevented pre-biopsy histologic predictions. HIV-negative group - There were no examples of collapsing focal segmental glomerulosclerosis or nonspecific immune complex disease, but increased numbers of minimal change and membranoproliferative disease. 'Classic HIVAN' accounted for less than a third of the nephropathies occurring in HIV-positive Black South Africans. 'HIVICK' is another important cause of chronic kidney disease in this group. Future research is needed into the earlier detection and treatment of these diseases, which have a high mortality in our context.
authors.affiliation: Dumisani Mzamane African Institute of Kidney Disease, Nephrology Department of Chris Hani Baragwanath Hospital, Soweto, South Africa. tgerntholz@hotmail.com
authors.forename: T E
authors.initials: TE
authors.lastname: Gerntholtz
authors.forename: S J W
authors.initials: SJ
authors.lastname: Goetsch
authors.forename: I
authors.initials: I
authors.lastname: Katz
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D000328:Adult; D044383:Black People; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005921:Glomerulonephritis / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006801:Humans; D007105:Immune Complex Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D007674:Kidney Diseases / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D015995:Prevalence; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology