Serous retinal detachment in a patient with aplastic anemia associated with parvovirus B19 infection.
BACKGROUND
We report a case of unilateral serous retinal detachment (RD) associated with parvovirus B19 infection.


METHODS
A 28-year-old woman had a clinical history of autoimmune hemolytic anemia and pure red cell aplasia associated with parvovirus B19 infection. She demonstrated focal serous RD without retinal exudates. A focal cataract and anterior vitreous cells were also observed. Fluorescein angiography (FA) revealed accumulation of subretinal fluid, but no vascular leakage. After vitrectomy, the retina was re-attached and visual acuity returned to 20/20. IgM antibody to parvovirus and viral DNA were detected by polymerase chain reaction in the vitreous fluid obtained at surgery.


CONCLUSIONS
To our knowledge, this is the first reported case of the presence of anti-viral IgM and viral DNA in vitreous sample. Furthermore, the ocular findings in our patient are definitively different from previously reported cases of parvovirus-associated ocular disorders.
Suzuki
Jun
J
Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. jun-s@qc4.so-net.ne.jp
Goto
Hiroshi
H
Usui
Masahiko
M
Sakai
Jun-ichi
J
D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D001769:Blood; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D015828:Eye Infections, Viral / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014821:Vitrectomy; D014822:Vitreous Body / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M