eEF1B: At the dawn of the 21st century.
Translational regulation of gene expression in eukaryotes can rapidly and accurately control cell activity in response to stimuli or when rapidly dividing. There is increasing evidence for a key role of the elongation step in this process. Elongation factor-1 (eEF1), which is responsible for aminoacyl-tRNA transfer on the ribosome, is comprised of two entities: a G-protein named eEF1A and a nucleotide exchange factor, eEF1B. The multifunctional nature of eEF1A, as well as its oncogenic potential, is currently the subject of a number of studies. Until recently, less work has been done on eEF1B. This review describes the macromolecular complexity of eEF1B, its multiple phosphorylation sites and numerous cellular partners, which lead us to suggest an essential role for the factor in the control of gene expression, particularly during the cell cycle.
Le Sourd
Frédéric
F
Equipe Cycle Cellulaire et Développement, Unité Mer and Sante, UMR 7150 CNRS/UPMC, Station Biologique de Roscoff, BP 74, 29682 Roscoff Cedex, France.
Boulben
Sandrine
S
Le Bouffant
Ronan
R
Cormier
Patrick
P
Morales
Julia
J
Belle
Robert
R
Mulner-Lorillon
Odile
O
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D046912:Multiprotein Complexes; D020648:Peptide Elongation Factor 1 / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D010802:Phylogeny
D046912:Multiprotein Complexes; D020648:Peptide Elongation Factor 1