Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes.
Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)n, n = 4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis.
Bellis
E
E
University of Athens, Laboratory of Organic Chemistry, 15771 Athens, Greece.
Hajba
L
L
Kovács
B
B
Sándor
K
K
Kollár
L
L
Kokotos
G
G
D000613:Aminobutyrates / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011126:Polypropylenes / Q000138:chemical synthesis / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013818:Thermogravimetry
D000613:Aminobutyrates; D050091:Dendrimers; D009944:Organoplatinum Compounds; D011126:Polypropylenes; C443641:poly(propyleneimine); D002945:Cisplatin