[Effects of Xuezhikang on serum levels of high sensitive-C reactive protein, matrix metalloproteinase-9 and lipoprotein in patients with acute coronary syndrome].
OBJECTIVE
To investigate the effects of Xuezhikang (XZK) on serum levels of high sensitivity-C reactive protein (Hs-CRP), matrix metalloproteinase-9 (MMP-9) and lipoprotein in patients with acute coronary syndrome (ACS).


METHODS
Sixty-nine ACS patients were divided into the XZK group (40 cases) treated with conventional therapy and XZK and the control group (29 cases) with conventional therapy alone, another 30 healthy persons were assigned as the normal group. Before and after the treatment, the levels of Hs-CRP, MMP-9 and lipids were detected.


RESULTS
Compared with those in the normal subjects, Hs-CRP and MMP-9 levels in the ACS patients increased significantly (P <0.05), parallel with the extent of myocardial injury. After 2 weeks of XZK treatment, levels of Hs-CRP and MMP-9 of the XZK group decreased significantly (P <0.05), while lipids levels had no remarkable changes.


CONCLUSIONS
Hs-CRP and MMP-9 levels were closely correlated to the genesis and severity of ACS. Anti-inflammatory action of XZK plays an important role in early stage treatment of ACS patients.
Huang
Jun
J
Department of Cardiology, the First Hospital Affiliated to Jiangri Medical College, Nanchang (330006). junhuang918@163.com
Wang
Meng-Hong
MH
Peng
Xiao-Ping
XP
Wei
Chunying
C
Lu
Jun
J
D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy; D002097:C-Reactive Protein / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D008517:Phytotherapy; D014280:Triglycerides / Q000097:blood
D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D020780:Matrix Metalloproteinase 9