Gadolinium-chlorin is potentially a new tumor specific MRI contrast agent.
In this study, a newly-synthesized metalloporphyrin, Gd-chlorin (PB Chlorin), was investigated by using a simple tissue phantom to test its efficacy as an MRI contrast agent. This study demonstrated the potential activity of Gd-chlorin as not only a MRI contrast agent, but also as a PDT photosensitizer by using a simple tissue phantom and conducting a very brief MRI experiment.
Kim
Jong-Ki
JK
PDT BIO CO Ltd, Seoul, Korea.
Kim
Dong-myung
DM
Kang
Min-Suk
MS
Kim
Hae-Kyung
HK
Kim
Jeong-Sook
JS
Yu
Eun-Kyung
EK
Jeong
Jin-Hyun
JH
D003287:Contrast Media / Q000138:chemical synthesis*; D017352:Echo-Planar Imaging / Q000295:instrumentation / Q000379:methods*; D008665:Metalloporphyrins / Q000138:chemical synthesis*; D019047:Phantoms, Imaging; D017319:Photosensitizing Agents / Q000138:chemical synthesis
D003287:Contrast Media; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; C511720:gadolinium-chlorin