Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.
Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
Agrawal
Arpana
A
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Edenberg
Howard J
HJ
Foroud
Tatiana
T
Bierut
Laura J
LJ
Dunne
Gerald
G
Hinrichs
Anthony L
AL
Nurnberger
John I
JI
Crowe
Raymond
R
Kuperman
Samuel
S
Schuckit
Marc A
MA
Begleiter
Henri
H
Porjesz
Bernice
B
Dick
Danielle M
DM
D000437:Alcoholism / Q000235:genetics*; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011963:Receptors, GABA-A / Q000235:genetics*; D019966:Substance-Related Disorders / Q000235:genetics
C484841:GABRA2 protein, human; D011963:Receptors, GABA-A; D004247:DNA