title: Gemfibrozil in the treatment of dyslipidemia: an 18-year mortality follow-up of the Helsinki Heart Study.
abstract: BACKGROUND
  The Helsinki Heart Study was a double-blind, placebo-controlled primary prevention trial among 4081 dyslipidemic middle-aged men to test the efficacy of gemfibrozil in the prevention of coronary heart disease (CHD). After the 5-year trial, the participants were notified of their treatment group and invited to continue or start gemfibrozil therapy free of charge through 1995. Approximately two thirds of participants in both groups chose gemfibrozil therapy. In this 18-year follow-up through 2000, we compared the CHD, cancer, and all-cause mortality among subjects in the original gemfibrozil (OG) group (n = 2046) with those in the original placebo (OP) group (n = 2035).
  
  
  METHODS
  To provide an overview of the absolute risks in the 2 treatment groups as well as risk differences between them, we calculated crude mortality rates and presented Kaplan-Meier plots of survival with log-rank tests. We also estimated the relative risks (RRs) using Cox proportional hazards models with and without covariates.
  
  
  RESULTS
  During the follow-up until 1995, subjects in the OG group had a 32% lower RR of CHD mortality (P = .03) compared with those in the OP group, and when followed up until 2000, the RR was 23% lower (P = .05). Overall, there were no differences in all-cause or cancer mortality. However, those in the OG group with both body mass index and triglyceride level in the highest tertiles had a 71% lower RR of CHD mortality (P<.001), a 33% lower RR of all-cause mortality (P = .03), and a 36% lower RR of cancer mortality (P = .22) compared with those in the OP group.
  
  
  CONCLUSIONS
  Long-term mortality follow-up showed that patients with dyslipidemia benefited from beginning treatment with gemfibrozil early, especially if their dyslipidemia entailed factors related to the metabolic syndrome.
authors.affiliation: Helsinki Heart Study, Helsinki, Finland.
authors.forename: Leena
authors.initials: L
authors.lastname: Tenkanen
authors.forename: Matti
authors.initials: M
authors.lastname: Mänttäri
authors.forename: Petri T
authors.initials: PT
authors.lastname: Kovanen
authors.forename: Hanna
authors.initials: H
authors.lastname: Virkkunen
authors.forename: Vesa
authors.initials: V
authors.lastname: Manninen
mesh_terms: D003327:Coronary Disease / Q000401:mortality* / Q000517:prevention & control; D004311:Double-Blind Method; D050171:Dyslipidemias / Q000188:drug therapy* / Q000401:mortality*; D005500:Follow-Up Studies; D015248:Gemfibrozil / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000960:Hypolipidemic Agents; D015248:Gemfibrozil