title: Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
abstract: The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.
authors.affiliation: Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. will.watkins@gilead.com
authors.forename: William J
authors.initials: WJ
authors.lastname: Watkins
authors.forename: James M
authors.initials: JM
authors.lastname: Chen
authors.forename: Aesop
authors.initials: A
authors.lastname: Cho
authors.forename: Lee
authors.initials: L
authors.lastname: Chong
authors.forename: Nicole
authors.initials: N
authors.lastname: Collins
authors.forename: Maria
authors.initials: M
authors.lastname: Fardis
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Magdeleine
authors.initials: M
authors.lastname: Hung
authors.forename: Thorsten
authors.initials: T
authors.lastname: Kirschberg
authors.forename: William A
authors.initials: WA
authors.lastname: Lee
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
authors.forename: William
authors.initials: W
authors.lastname: Thomas
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Ameneh
authors.initials: A
authors.lastname: Zeynalzadegan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Zhang
mesh_terms: D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D063065:Organophosphonates; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid