Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
Kiat
Tan Siew
TS
Sunway University College, Bandar Sunway, 46150, P.J. Selangor, Malaysia.
Pippen
Richard
R
Yusof
Rohana
R
Ibrahim
Halijah
H
Khalid
Norzulaani
N
Rahman
Noorsaadah Abd
NA
D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D003510:Cyclohexanes / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000378:metabolism*; D030521:Zingiberaceae / Q000737:chemistry*; D000085242:Viral Proteases
D002599:Chalcone; D003510:Cyclohexanes; D005419:Flavonoids; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; C512303:cyclohexenyl chalcone; C504449:NS3 protease, dengue virus; D000085242:Viral Proteases