Chemical and biological evaluation on scopadulane-type diterpenoids from Scoparia dulcis of Vietnamese origin.
From the aerial parts of Scoparia dulcis L. (Scrophulariaceae) grown in Vietnam, four scopadulane-type diterpenoids (4-7), of which 7 is new and was given the trivial name scopadulcic acid C, together with nine known compounds were isolated. Their structures were elucidated by spectroscopic analyses. The absolute configurations of 4-7 were ascertained by applying the modified Mosher's method to iso-dulcinol (6). The isolation of the lignans nirtetralin and niranthin for the first time from S. dulcis is also of chemotaxonomic interest. The cytotoxic activity in KB cells, inhibitory effect on LPS/IFNgamma-induced NO production, inhibition of multidrug resistance (MDR), and antibacterial and antifungal activities of the scopadulane-type diterpenoids 4-7 were examined in this study.
Phan
Minh Giang
MG
Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam.
Phan
Tong Son
TS
Matsunami
Katsuyoshi
K
Otsuka
Hideaki
H
D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D007371:Interferon-gamma / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D036721:Scoparia / Q000737:chemistry*; D028083:Scrophulariaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014744:Vietnam
D000840:Anisoles; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D004149:Dioxoles; D004224:Diterpenes; D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C475932:niranthin; C475933:nirtetralin; D007371:Interferon-gamma