Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia.
Numerous linkage studies suggest that chromosome 5q may be one of the important cytogenetic regions containing risk loci for schizophrenia susceptibility. Recently, genetic variations (rs254664 and rs10046055) in the intron 1 and 5' flanking regions of the ENTH (also known as Epsin 4) gene, which is located in 5q 33.3, have been demonstrated to be significantly associated with schizophrenia. The present study investigates whether this finding could be replicated in a population of Han Chinese, consisting of 269 patients with schizophrenia and 236 normal controls, by analyzing 9 single nucleotide polymorphisms (SNPs) ranging from the 5' upstream region to intron 8 of the ENTH gene and covering 96 kb. The results showed that we failed to identify the associations of rs1186922 and rs10046055 with schizophrenia. Although another genetic variation (rs1186922) showed a weak association with schizophrenia (uncorrected p value for alleles = 0.038), the significance did not survive after Bonferroni correction. This study thus fails to support an association of genetic variations in the ENTH gene and schizophrenia.
Liou
Ying-Jay
YJ
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Lai
I-Ching
IC
Wang
Ying-Chieh
YC
Bai
Ya-Mei
YM
Lin
Chao-Cheng
CC
Lin
Chih-Yuan
CY
Chen
Tzu-Ting
TT
Chen
Jen-Yeu
JY
D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005091:Exons; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D033942:Adaptor Proteins, Vesicular Transport; C475910:CLINT1 protein, human