In vitro studies toward noninvasive glucose monitoring with optical coherence tomography.
We use optical coherence tomography (OCT) to measure glucose-induced changes in Intralipid and in mouse skin samples in vitro. Mouse skin samples are cultured in a CO2 incubator before measurements are made with different amounts of added glucose concentrations. The results show that the glucose-induced changes in the OCT slope value vary between 20% and 52%/30 mM glucose in different mouse skin samples. This change is much larger than the change in 2% Intralipid (2.1%/30 mM) and in 5% Intralipid (0.86%/30 mM). Hence the results show that OCT has potential to monitor glucose-induced changes in tissues in vitro.
Kinnunen
Matti
M
Optoelectronics and Measurement Techniques Laboratory and Infotech Oulu, University of Finland. matti.kinnunen@ee.oulu.fi
Myllylä
Risto
R
Jokela
Tiina
T
Vainio
Seppo
S
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000379:methods*; D066298:In Vitro Techniques; D051379:Mice; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000098:blood supply* / Q000378:metabolism*; D041623:Tomography, Optical Coherence / Q000379:methods*
D001786:Blood Glucose