Fluoroquinolone resistance in Ureaplasma parvum in the United States.
We report the first case of naturally occurring fluoroquinolone resistance in Ureaplasma spp. from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure.
Duffy
Lynn
L
Department of Pathology, WP 230, 619 19th St. South, University of Alabama at Birmingham, Birmingham, AL 35226, USA.
Glass
John
J
Hall
Geraldine
G
Avery
Robin
R
Rackley
Raymond
R
Peterson
Scott
S
Waites
Ken
K
D000328:Adult; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D014481:United States; D014509:Ureaplasma / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology
D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase