title: A new total synthesis of porritoxin.
abstract: A concise and efficient total synthesis of the phytotoxin porritoxin is described. The key step of the synthesis is based upon a Parham cyclization methodology which enables the creation of the lactam unit embedded in the title compound framework with the concomitant formation of the tethered hydroxyakyl chain.
authors.affiliation: Laboratoire de Chimie Organique Physique, UMR 8009 Chimie Organique et Macromoléculaire, Université des Sciences et technologies de Lille, Bâtiment C3(2), F-59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Moreau
authors.forename: Magali
authors.initials: M
authors.lastname: Lorion
authors.forename: Axel
authors.initials: A
authors.lastname: Couture
authors.forename: Eric
authors.initials: E
authors.lastname: Deniau
authors.forename: Pierre
authors.initials: P
authors.lastname: Grandclaudon
mesh_terms: D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D054833:Isoindoles; D015394:Molecular Structure
chemical_list: D007211:Indoles; D054833:Isoindoles; C466610:porritoxin