title: Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
abstract: Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kainuma
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kasuga
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Hosoda
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Aya
authors.initials: A
authors.lastname: Tanatani
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Makoto
authors.initials: M
authors.lastname: Makishima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001559:Benzhydryl Compounds; D004268:DNA-Binding Proteins; D008024:Ligands; D047493:PPAR alpha; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated; C010129:diphenylmethane