Sesquiterpenes with various carbon skeletons from Ligularia virgaurea spp. oligocephala.
Two new 8,9-seco-cacalol-type sesquiterpene lactones, ligulolide C (1 and 2) and six known sesquiterpenes, adenostylide (3 and 4), cacalol (5), 1 -hydroxy-2-(3'-pentenyl)-3,7-dimethylbenzofuran (6), 1beta, 6alpha-dihydroxy-4(14)-eudesmene (7) and (+)-oplopanone (8), have been isolated from an extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structures of 1 and 2 were confirmed by spectroscopic methods including 1D and 2D NMR spectra. A discussion of biogenesis of 1 and 2 was described. Cytotoxicity against selected cancer cells human promyelocytic leukemia (HL-60), human ovarian (HO-8910) and human lung epithehial (A-549) of compounds 1-8 were measured in vitro.
Wu
Quan-Xiang
QX
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
We
Qing-Yi
QY
Shi
Yan-Ping
YP
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D005047:Etoposide / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D010936:Plant Extracts; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; D005047:Etoposide; C022616:thiazolyl blue