Regioselective dicouplings: application to differentially substituted pyrroles.
[reaction: see text] In an effort to develop a more concise route to differentially substituted pyrroles (such as that found in the lamellarins), a completely regioselective one-pot double Suzuki coupling has been discovered. The key feature is the use of a ligand-free palladium catalyst under optimized conditions, which results only in coupling of the C5 bromide. At this point, addition of a second boronic acid and a phosphine ligand enables coupling at the remaining C4 bromide.
Handy
Scott T
ST
Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, USA. shandy@mtsu.edu
Sabatini
Jesse J
JJ