title: Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2.
abstract: The controllability of stressors modulates many of the consequences of stressor exposure. Here, we used immunohistochemistry to examine neural progenitor cell proliferation and survival and basic fibroblast growth factor-2 in the hippocampus of male rats after controllable or uncontrollable tailshock. A series of identical tailshocks were delivered to yoked pairs of rats. One rat could terminate shocks to both rats of the pair. Reductions in neural progenitor cells were observed at 1-2 days and at 28 days in rats exposed to uncontrollable shock. Controllable shock produced an increase in fibroblast growth factor-2 in the dentate gyrus and CA1 2 h after stress and in the dentate gyrus 24 h after stress. Thus, stressor controllability modulates stress-induced decreases in neurogenesis and increases in fibroblast growth factor-2.
authors.affiliation: Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, 80309-0345, USA. sondra.bland@colorado.edu
authors.forename: Sondra T
authors.initials: ST
authors.lastname: Bland
authors.forename: Megan J
authors.initials: MJ
authors.lastname: Schmid
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Greenwood
authors.forename: Linda R
authors.initials: LR
authors.lastname: Watkins
authors.forename: Steven F
authors.initials: SF
authors.lastname: Maier
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation; D002470:Cell Survival; D004597:Electroshock / Q000009:adverse effects; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D051381:Rats; D013234:Stem Cells / Q000502:physiology*; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D013623:Tail / Q000294:innervation / Q000528:radiation effects
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016222:Fibroblast Growth Factor 2; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine