title: Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formation.
abstract: We describe three unusual tumours characterized by a mixture of glial and neuronal differentiation, involvement of the posterior fossa and formation of rosettes. Mixed glial-neuronal tumours of the posterior fossa are rare and poorly described neoplasms. However, several distinctive entities have appeared in the literature over recent years under a variety of different names. Our cases demonstrate the morphological features of the 'rosette-forming glioneuronal tumour of the fourth ventricle', a recently identified tumour characterised by its unique location, neurocytic pseudo-rosette formation and the presence of a low grade astrocytoma component. The long term prognosis of these tumours remains unclear. However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection.
authors.affiliation: Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. t.jacques@ich.ucl.ac.uk
authors.forename: T S
authors.initials: TS
authors.lastname: Jacques
authors.forename: C
authors.initials: C
authors.lastname: Eldridge
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: N M
authors.initials: NM
authors.lastname: Saleem
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: N D
authors.initials: ND
authors.lastname: Kitchen
authors.forename: M
authors.initials: M
authors.lastname: Thom
authors.forename: T
authors.initials: T
authors.lastname: Revesz
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D020546:Fourth Ventricle / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D018306:Neurocytoma / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009457:Neuroglia / Q000473:pathology*