Programming CD8+ T cells for effective immunotherapy.
The differentiation state of CD8+ T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct the differentiation process. These signals 'program' sustained and heritable gene expression patterns that govern progressive differentiation and lineage commitment. The epigenetic mechanisms by which T cells are programmed are just beginning to be elucidated. Understanding the mechanisms that control CD8+ T-cell differentiation is important in the development of novel immunotherapy strategies.
Hinrichs
Christian S
CS
National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Gattinoni
Luca
L
Restifo
Nicholas P
NP
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007167:Immunotherapy; D018448:Models, Immunological
D016207:Cytokines