Linking lipids, Alzheimer's and LXRs?
Deposition of the beta-amyloid (Abeta) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Abeta production. It is becoming increasingly clear that altered cholesterol homeostasis can modulate Abeta production and/or accumulation. In this review, we discuss the molecular pathology of AD, the cholesterol connection and recent data suggesting that the oxysterol receptor, liver X receptor LXR (NR1H2 and NR1H3), may modulate these events.
Patel
Nilay V
NV
Gonda Diabetes Center, City of Hope National Medical Center, Duarte, CA 91010, USA.
Forman
Barry Marc
BM