[Relationship between serum interleukin-10 and insulin resistance in metabolic syndrome].
OBJECTIVE
To investigate the relationship between serum interleukin-10 (IL-10) level and insulin resistance (IR) in patients with metabolic syndrome (MS).


METHODS
Eighteen MS subjects and 18 age-matched normal subjects were enrolled. IR was evaluated by hyperinsulinemic-euglycemic clamp technique and serum IL-10 level measured by ELISA. Pearson's correlation analysis was used to investigate the relationship between serum IL-10 level and IR.


RESULTS
Serum IL-10 levels were significantly higher in patients with MS than in the controls [1.3 (0.8/3.1) pg/ml vs 2.4 (1.1/4.5) pg/ml, P<0.05], and glucose metabolic rate (M value) derived from hyperinsulinemic-euglycemic clamp technique was lower in MS subjects than in controls [(5.76+/-1.81) mg/kg.min vs (8.39+/-1.25) mg/kg.min], P<0.05]. Serum IL-10 levels showed a positive correlation with M value (P<0.05).


CONCLUSIONS
Patients with MS have greater IR and lower serum IL-10 levels than normal subjects, and lowered IL-10 levels might be involved in the pathogenesis of IR in MS.
Ye
Jian-hong
JH
Department of Endocrinology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Li
Zhi-zhen
ZZ
Li
Yan
Y
Li
Feng
F
Yan
Li
L
Cheng
Hua
H
Fu
Zu-zhi
ZZ
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged
D016753:Interleukin-10