Sevoflurane alters right ventricular performance but not pulmonary vascular resistance in acutely instrumented anesthetized pigs.
OBJECTIVE
Although the effects of halogenated agents on both normal and diseased left ventricles have been widely studied, the influence of these anesthetic agents on right ventricular (RV) performance remains less well characterized. This study was undertaken to examine the effects of 2 different concentrations of sevoflurane on RV function, and coronary and pulmonary hemodynamics in acutely instrumented anesthetized pigs.


METHODS
Prospective experimental study.


METHODS
Laboratory of experimental research in a university teaching hospital.


METHODS
Anesthetized pigs.


METHODS
Regional RV function in 10 pigs was determined from pressure segment length loop analysis, global RV function from stroke work versus end-diastolic pressure relation, right coronary blood flow, and pulmonary vascular resistance (PVR), without and then with 2.6% (minimum alveolar concentration [MAC]) and 3.9 % (1.5 MAC) end-tidal sevoflurane concentrations.


RESULTS
Sevoflurane preserved inflow systolic shortening and RV regional external work, but significantly depressed outflow systolic shortening (p < 0.05). Global RV stroke work was depressed to 72% +/- 12% and 61% +/- 10% of baseline value, respectively, with 1 and 1.5 MAC of sevoflurane (p < 0.05), but without alteration of PVR. Right coronary blood flow decreased dose dependently.


CONCLUSIONS
Sevoflurane causes significant depression of global RV function associated with a qualitatively different effect on inflow and outflow tracts, without any modification of PVR.
Kerbaul
François
F
Laboratoire d'Hémodynamique et de Mécanique Cardiovascular, Hôpital Timone adultes, Marseille, France. fkerbaul@yahoo.fr
Bellezza
Maurice
M
Mekkaoui
Choukri
C
Feier
Horéa
H
Guidon
Catherine
C
Gouvernet
Joanny
J
Rolland
Pierre-Henri
PH
Gouin
François
F
Mesana
Thierry
T
Collart
Frédéric
F
D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D008738:Methyl Ethers / Q000008:administration & dosage*; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology*; D000077149:Sevoflurane; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects*; D016278:Ventricular Function, Right / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane