title: Circulating adiponectin concentrations in patients with congestive heart failure.
abstract: OBJECTIVE
  To determine concentrations of adiponectin and its predictive value on outcome in a cohort of patients with congestive heart failure (CHF).
  
  
  METHODS
  Serum and clinical data were obtained for outpatients with clinically controlled CHF (n = 175). Serum concentrations of adiponectin, C reactive protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin (IL) -1beta, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor alpha and CD-40 ligand were determined. The association of adiponectin with the clinical severity of CHF was sought as well as the predictive value of this adipokine on mortality, CHF hospitalisations or the occurrence of each of these end points.
  
  
  RESULTS
  Concentrations of adiponectin were significantly increased in patients with CHF. Patients with higher New York Heart Association class had significantly higher serum concentrations of adiponectin. Adiponectin serum concentrations were lower in patients with diabetes and CHF as well as in patients with ischaemic cardiomyopathy. Serum adiponectin concentration was positively associated with age and NT-proBNP but was negatively correlated with C reactive protein concentrations. Serum adiponectin above the 75th centile was found to be an independent predictor of total mortality, CHF hospitalisations or a composite of these end points over a two-year prospective follow up.
  
  
  CONCLUSIONS
  Adiponectin is increased in CHF patients and predicts mortality and morbidity.
authors.affiliation: The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. jacobg@post.tau.ac.il
authors.forename: J
authors.initials: J
authors.lastname: George
authors.forename: S
authors.initials: S
authors.lastname: Patal
authors.forename: D
authors.initials: D
authors.lastname: Wexler
authors.forename: Y
authors.initials: Y
authors.lastname: Sharabi
authors.forename: E
authors.initials: E
authors.lastname: Peleg
authors.forename: Y
authors.initials: Y
authors.lastname: Kamari
authors.forename: E
authors.initials: E
authors.lastname: Grossman
authors.forename: D
authors.initials: D
authors.lastname: Sheps
authors.forename: G
authors.initials: G
authors.lastname: Keren
authors.forename: A
authors.initials: A
authors.lastname: Roth
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D016207:Cytokines / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; D002097:C-Reactive Protein