CK2 signaling in androgen-dependent and -independent prostate cancer.
Protein serine/threonine kinase casein kinase 2 (CK2) is a key player in cell growth and proliferation but is also a potent suppressor of apoptosis. CK2 has been found to be dysregulated in all the cancers that have been examined, including prostate cancer. Investigations of CK2 signaling in the prostate were originally initiated in this laboratory, and these studies have identified significant functional activities of CK2 in relation to normal prostate growth and to the pathobiology of androgen-dependent and -independent prostate cancer. We present a brief overview of these developments in the context of prostate biology. An important outcome of these studies is the emerging concept that CK2 can be effectively targeted for cancer therapy.
Wang
Guixia
G
Cellular and Molecular Biochemistry Research Laboratory (151), Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA.
Ahmad
Kashif A
KA
Unger
Gretchen
G
Slaton
Joel W
JW
Ahmed
Khalil
K
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D047390:Casein Kinase II / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D008954:Models, Biological; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
D000728:Androgens; D047390:Casein Kinase II