Novel serum inflammatory markers in patients with adnexal mass who had surgery for ovarian torsion.
OBJECTIVE
To determine the diagnostic value of preoperative levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and E-selectin in patients with an adnexal mass who had surgery for ovarian torsion.


METHODS
Prospective study.


METHODS
University hospital.


METHODS
Fifty consecutive women with adnexal mass who were admitted with a diagnosis of ovarian torsion.


METHODS
All had a single preoperative measurement of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA.


METHODS
To determine if a single preoperative serum sampling of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA can diagnose ovarian torsion.


RESULTS
Thirteen patients had proven torsion of the ovary. Serum levels of IL-6 were significantly higher in the 13 patients with proven ovarian torsion compared with the 37 without ovarian torsion. Patients with IL-6 serum values > or =10.2 pg/mL had a 16 times higher risk of having ovarian torsion. No significant difference was found in TNF-alpha, IL-8, and E-selectin between the two groups.


CONCLUSIONS
The IL-6 levels might assist in the prompt diagnosis of ovarian torsion and allow a timely surgical intervention.
Daponte
Alexandros
A
Department of Obstetrics and Gynaecology, University Hospital of Larissa, Larissa, Greece. dapontea@otenet.gr
Pournaras
Spyros
S
Hadjichristodoulou
Christos
C
Lialios
Georgios
G
Kallitsaris
Athanasios
A
Maniatis
Antonios N
AN
Messinis
Ioannis E
IE
D000291:Adnexal Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014102:Torsion Abnormality / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000601:surgery
D015415:Biomarkers; D016207:Cytokines