Life-threatening intoxication with methylene bis(thiocyanate): clinical picture and pitfalls. A case report.
BACKGROUND
Methylene bis(thiocyanate) (MBT) is a microbiocidal agent mainly used in industrial water cooling systems and paper mills as an inhibitor of algae, fungi, and bacteria.


METHODS
We describe the first case of severe intoxication following inhalation of powder in an industrial worker. Profound cyanosis and respiratory failure caused by severe methemoglobinemia developed within several minutes. Despite immediate admission to the intensive care unit, where mechanical ventilation and hemodialysis for toxin elimination were initiated, multi-organ failure involving liver, kidneys, and lungs developed. While liver failure was leading, the patient was successfully treated with the MARS (molecular adsorbent recirculating system) procedure.


CONCLUSIONS
Intoxication with MBT is a potentially life-threatening intoxication causing severe methemoglobinemia and multi-organ failure. Extracorporeal liver albumin dialysis (MARS) appears to be an effective treatment to allow recovery of hepatic function.
Braun
Claude
C
Department of Medicine V, Nephrology/Endocrinology/Rheumatology, University Medical Center Mannheim, University of Heidelberg, D-68135 Mannheim, Germany. cbraun@rumms.uni-mannheim.de
Birck
Rainer
R
Singer
Manfred V
MV
Schnuelle
Peter
P
van der Woude
Fokko J
FJ
Löhr
Matthias
M