[The course of gastroesophageal reflux disease in elderly patients with concomitant ischemic heart disease].
OBJECTIVE
To study basic functional and pathogenetic features of the course of gastroesophageal reflux disease (GERD) in elderly patients with concomitant coronary heart disease (CHD).


METHODS
Esophagogastroduodenoscopy, 24-h pH-metry, simultaneous 24-h pH- and ECG-monitoring, omeprasol test were made in 126 patients: 74 GERD patients with CHD and 52 patients with GERD alone.


RESULTS
Mean number of refluxes for 24 hours in isolated GERD was maximal at stages IIa and IIb (74%). In CHD patients (77%) there was a trend to a rise in this number. Only patients with associated CHD demonstrated a clinically significant depression of ST segment related to reflux, a significantly more frequent occurrence of supraventricular and ventricular extrasystoles.


CONCLUSIONS
The acid component of gastric content pushed into the esophagus is not a leading factor of esophageal mucosa lesion in GERD patients with CHD. Pathological gastroesophageal refluxes may trigger mechanisms provoking new attacks of angina pectoris.
Zvenigorodskaia
L A
LA
Taranchenko
Iu V
IuV
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D015716:Electrocardiography, Ambulatory; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011379:Prognosis; D012720:Severity of Illness Index