title: Copper(II)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling.
abstract: [reaction: see text] Optimized conditions for the decoration of the 2(1H)-pyrazinone scaffold were developed by applying the Chan-Lam protocol. It was demonstrated that this Cu(II)-mediated cross-coupling reaction resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling at 0 degrees C, applying a mixture of bases Et(3)N/pyridine.
authors.affiliation: Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Leuven, Belgium.
authors.forename: Brajendra Kumar
authors.initials: BK
authors.lastname: Singh
authors.forename: Prasad
authors.initials: P
authors.lastname: Appukkuttan
authors.forename: Stijn
authors.initials: S
authors.lastname: Claerhout
authors.forename: Virinder Singh
authors.initials: VS
authors.lastname: Parmar
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken