title: The effects of desferrioxamine and quercetin on liver injury induced by hepatic ischaemia-reperfusion in rats.
abstract: BACKGROUND
  This study was designed to examine the effects of desferrioxamine and quercetin on hepatic ischaemia-reperfusion injury in rat.
  
  
  METHODS
  Thirty Wistar albino rats were randomized into five groups. Group I was the control group. Group II received no treatment. Group III and group IV received intramuscular injections of desferrioxamine (100 mg/kg per day) and quercetin (50 mg/kg per day) respectively. Group V was administered desferrioxamine and quercetin in combination. After treatment for 3 days, groups II, III, IV, and V were exposed to total hepatic ischaemia for 45 minutes. Plasma alanine aminotransferase levels, malondialdehyde and reduced glutathione activities were measured after reperfusion for 1 hour. Histopathological analysis of liver tissues was carried out.
  
  
  RESULTS
  Our results indicated that tissue malondialdehyde levels and histopathological liver damage scores were significantly higher in the ischaemia-reperfusion group than in the control group. Administration of desferrioxamine, quercetin, and desferrioxamine+quercetin significantly decreased these parameters. Plasma alanine aminotransferase levels were also increased after ischaemia-reperfusion. Quercetin and desferrioxamine + quercetin significantly decreased the activity of this enzyme when compared to ischaemia-reperfusion group.
  
  
  CONCLUSIONS
  The present data suggest that both desferrioxamine and quercetin may be useful to protect against ischaemia-reperfusion induced liver damage.
authors.affiliation: Department of Pathology, Kocatepe University, Faculty of Medicine, Afyon, Turkey. ctokyol@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Tokyol
authors.forename: S
authors.initials: S
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Kahraman
authors.forename: H
authors.initials: H
authors.lastname: Cakar
authors.forename: C
authors.initials: C
authors.lastname: Polat
mesh_terms: D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D008111:Liver Function Tests; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D017262:Siderophores / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D017262:Siderophores; D011794:Quercetin; D003676:Deferoxamine