Hibernation proteins: preparing for life in the freezer.
Hibernation is an extreme response to a seasonal environment, yet we know almost nothing about how it is timed or how vital cellular functions are sustained in the face of plummeting body temperature. In this issue of Cell, kondo et al. (2006) identify a liver-derived protein complex as an essential coordinator of this adaptation to the depredations of winter.
Hastings
Michael H
MH
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. mha@mrc-lmb.cam.ac.uk
Ebling
Francis J P
FJ
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology; D003081:Cold Climate; D003080:Cold Temperature; D006605:Hibernation / Q000502:physiology*; D046912:Multiprotein Complexes / Q000378:metabolism*; D012621:Seasons
D001798:Blood Proteins; C081698:HP-20 protein, Tamias asiaticus; D046912:Multiprotein Complexes