Investigation of a route to ibotenic acid analogues via a reduced pyroglutamate template.
Two alternative "ring switch" based syntheses have been shown to give access to the reduced protected homochiral analogues, 27, 28 and 36, of the CNS active compound ibotenic acid.
Ahmed
Omar
O
Department of Chemistry, University of Sussex, Falmer, Brighton, UK BN1 9QJ.
Hitchcock
Peter B
PB
Young
Douglas W
DW
D018690:Excitatory Amino Acid Agonists / Q000138:chemical synthesis / Q000737:chemistry; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011761:Pyrrolidonecarboxylic Acid / Q000737:chemistry*
D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid; D011761:Pyrrolidonecarboxylic Acid