title: Synthesis of substituted pyridine derivatives via the ruthenium-catalyzed cycloisomerization of 3-azadienynes.
abstract: We describe a two-step conversion of various N-vinyl and N-aryl amides to the corresponding substituted pyridines and quinolines, respectively. The process involves the direct conversion of amides, including sensitive N-vinyl amides, to the corresponding trimethylsilyl alkynyl imines followed by a ruthenium-catalyzed protodesilylation and cycloisomerization. A wide range of new alkynyl imines are prepared and readily converted to the corresponding azaheterocycles.
authors.affiliation: Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, USA. movassag@mit.edu
authors.forename: Mohammad
authors.initials: M
authors.lastname: Movassaghi
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hill