Reusable polymer-supported catalyst for the [3+2] Huisgen cycloaddition in automation protocols.
[reaction: see text] A polymer-supported catalyst for Huisgen's [3+2] cycloaddition reaction between azides and alkynes was prepared from copper(I) iodide and Amberlyst A-21. This catalyst was then used in an automated synthesis of 1,4-disubstituted 1,2,3-triazoles giving access to these products in good yields. The catalyst has shown good activity, stability, and recycling capabilities.
Girard
Christian
C
Inserm, U640, Paris, F-75006 France. christian-girard@enscp.fr
Onen
Esra
E
Aufort
Marie
M
Beauvière
Sophie
S
Samson
Edmond
E
Herscovici
Jean
J