title: Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease.
abstract: OBJECTIVE
  To determine whether Apolipoprotein E4 (Apo E4) gene status or ApoE gene dose affect the lipid profile in AD.
  
  
  BACKGROUND
  Links between hypercholesterolemia and AD development continue to grow. Presently, limited information exists about the influence of the Apo E genotype on the lipid profile characteristics in AD.
  
  
  METHODS
  We examined the lipid profiles (total cholesterol (TC), high-density lipoprotein (HDL), lower-density lipoprotein (LDL), TC/HDL ratio, and triglyceride (TG) levels) of 142 subjects with probable or possible AD (mean age 76.5 +/- 8.9 years), not on lipid lowering therapy by Apo E genotype. Assessment was done by gene status and gene dose.
  
  
  RESULTS
  ApoE4 gene status did not reveal any significant differences in the lipid profile except for LDL. However, significant differences were observed by ApoE gene dose.
  
  
  CONCLUSIONS
  ApoE gene status has minimal influence on the lipid panel or mean age in AD. Apo E gene dose does influence the lipid panel with Apo E 2/2, and 2/3 having significantly better lipid panels and older age of onset.
authors.affiliation: The Cleo Roberts Center for Clinical Research Sun Health Research Institute, Sun City, AZ 85351, USA. Marwan.Sabbagh@sunhealth.org
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.forename: Shawn
authors.initials: S
authors.lastname: Sandhu
authors.forename: Heather
authors.initials: H
authors.lastname: Kolody
authors.forename: Tyson
authors.initials: T
authors.lastname: Lahti
authors.forename: Nina B
authors.initials: NB
authors.lastname: Silverberg
authors.forename: D Larry
authors.initials: DL
authors.lastname: Sparks
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol