Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer.
OBJECTIVE
To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.


METHODS
Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.


RESULTS
The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp-group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp-group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71, 25.33+4.76, and 18.80+2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47+1.44, 17.29+2.04, 15.30+1.38, 13.11+0.93 and 12.14+1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant.


CONCLUSIONS
The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.
Xie
Xiao-Zhi
XZ
Department of Pathology, Children's Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China. xiaozhixie@126.com
Zhao
Zhi-Guang
ZG
Qi
Dan-Si
DS
Wang
Zong-Min
ZM
D002648:Child; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000378:metabolism*; D005755:Gastrins / Q000032:analysis*; D005756:Gastritis / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D011706:Pyloric Antrum / Q000737:chemistry*; D012189:Retrospective Studies; D013004:Somatostatin / Q000032:analysis*
D005755:Gastrins; D013004:Somatostatin