title: Beta2-microglobulin, a uremic toxin with a double meaning.
abstract: beta(2)M is a strong and independent indicator of hemodialysis patient outcomes and an excellent surrogate for middle molecules, and deserves to be routinely monitored and incorporated into dialysis adequacy targets. beta(2)M has a double meaning, reflecting both dialysis efficacy in terms of solute mass transfer and patient bioactivity. The work of Ward et al. in this issue warrants a study to test the hypothesis that long daily hemodiafiltration treatment would be the optimal renal replacement modality to improve dialysis patient outcomes.
authors.affiliation: Nephrology, Dialysis and Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France. b-canaud@chu-montpellier.fr
authors.forename: B
authors.initials: B
authors.lastname: Canaud
authors.forename: M
authors.initials: M
authors.lastname: Morena
authors.forename: J P
authors.initials: JP
authors.lastname: Cristol
authors.forename: D
authors.initials: D
authors.lastname: Krieter
mesh_terms: D001825:Body Fluid Compartments; D017583:Hemodiafiltration; D015312:Hemodialysis Solutions / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D014511:Uremia / Q000097:blood / Q000517:prevention & control*; D001613:beta 2-Microglobulin / Q000097:blood / Q000633:toxicity*
chemical_list: D015312:Hemodialysis Solutions; D001613:beta 2-Microglobulin