Clinico-pathological significance of RCAS1 expression in gliomas: a potential mechanism of tumor immune escape.
RCAS1, one of the tumor cell surface antigens, is strongly expressed in aggressive tumors. RCAS1 suppresses the in vitro growth of immune effector cells. We investigated the expression of RCAS1 in 57 gliomas using immunohistochemistry. Furthermore, we examined the association of the RCAS1 expression with the infiltration of tumor infiltrating lymphocyte (TIL). RCAS1 overexpression was significantly correlated with high histological grade and poor prognosis. Reduced infiltration and increased apoptosis of TILs was observed in RCAS1-positive regions. Apoptotsis of TILs appeared to be induced by RCAS1. RCAS1 expression in gliomas may play roles in tumor progression and tumor immune escape.
Nakabayashi
Hiromichi
H
Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Kochi, Japan. nakarinh@med.kochi-u.ac.jp
Nakashima
Manabu
M
Hara
Mitsuhiro
M
Toyonaga
Shinichi
S
Yamada
Shoko M
SM
Park
Kae Chang
KC
Shimizu
Keiji
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D017209:Apoptosis; D002648:Child; D005260:Female; D005910:Glioma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods / Q000706:statistics & numerical data; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
D000951:Antigens, Neoplasm; C120762:EBAG9 protein, human; D019394:Ki-67 Antigen; D017493:Leukocyte Common Antigens