title: [Relationship between the expression of fragile histidine (FHIT) and the development of vulvar carcinoma].
abstract: OBJECTIVE
  To explore the relationship between the reduction of FHIT expression of fragile histidine (FHIT) and the development of vulvar carcinoma.
  
  
  METHODS
  The expression of the FHIT product was detected by immunochemistry in the tissue samples of 20 normal vulvas, 22 vulvar intraepithelial neoplasias (VINs), and 60 primary vulvar carcinomas.
  
  
  RESULTS
  The expressive rates of FHIT protein in the squamous epithelium of normal vulvas, VIN I - II, VIN II, and noninvasive and invasive vulvar carcinoma were 100% (20/20), 72.7% (8/11), 45.5% (5/11), and 21.7% (13/60) respectively (P<0.05). The expressive rates of FHIT protein in the well differentiated, intermediately differentiated and poorly differentiated invasive vulav carcinoma were 60.0% (9/15), 20.0% (3/15), and 3.3% (1/30) respectively (P<0.05). The expressive rate of the impaired FHIT protein in the invasive vulva carcinoma with lymphnode metastasis (10%) was lower than that without lymphnode metastasis (27.5%).
  
  
  CONCLUSIONS
  Abnormal FHIT expression may play an important role in the progression of vulvar carcinoma. The expression of FHIT may provide important information for the prognosis of vulva carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Chu
authors.forename: Ai
authors.initials: A
authors.lastname: Zheng
authors.forename: Ming-Rong
authors.initials: MR
authors.lastname: Xi
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014846:Vulvar Neoplasms / Q000378:metabolism* / Q000473:pathology; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase