title: Heat shock proteins: endogenous modulators of apoptotic cell death.
abstract: The highly conserved heat shock proteins (Hsps) accumulate in cells exposed to heat and a variety of other stressful stimuli. Hsps, that function mainly as molecular chaperones, allow cells to adapt to gradual changes in their environment and to survive in otherwise lethal conditions. The events of cell stress and cell death are linked and Hsps induced in response to stress appear to function at key regulatory points in the control of apoptosis. Hsps include anti-apoptotic and pro-apoptotic proteins that interact with a variety of cellular proteins involved in apoptosis. Their expression level can determine the fate of the cell in response to a death stimulus, and apoptosis-inhibitory Hsps, in particular Hsp27 and Hsp70, may participate in carcinogenesis. This review summarizes the apoptosis-regulatory function of Hsps.
authors.affiliation: Faculty of Medicine and Pharmacy, INSERM U-517, Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Didelot
authors.forename: E
authors.initials: E
authors.lastname: Schmitt
authors.forename: M
authors.initials: M
authors.lastname: Brunet
authors.forename: L
authors.initials: L
authors.lastname: Maingret
authors.forename: A
authors.initials: A
authors.lastname: Parcellier
authors.forename: C
authors.initials: C
authors.lastname: Garrido
mesh_terms: D000818:Animals; D017209:Apoptosis; D018834:Chaperonin 60 / Q000502:physiology; D050957:HSP110 Heat-Shock Proteins / Q000502:physiology; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000502:physiology; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology
chemical_list: D018834:Chaperonin 60; D050957:HSP110 Heat-Shock Proteins; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins