Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells.
Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.
Salunke
Deepak B
DB
Organic Chemistry Synthesis Division, National Chemical Laboratory, Pune 411 008, India.
Ravi
Dyavar S
DS
Pore
Vandana S
VS
Mitra
Debashis
D
Hazra
Braja G
BG
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000821:virology*; D002460:Cell Line; D002478:Cells, Cultured; D019826:Cholic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015726:Giant Cells / Q000187:drug effects* / Q000821:virology; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects* / Q000502:physiology
D019826:Cholic Acid