Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats.
Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6h/day, during days 6-20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000 ppm EB and 3000 ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000 ppm EB or 3000 ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.
Saillenfait
A M
AM
Institut National de Recherche et de Sécurité, 54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.fr
Gallissot
F
F
Sabaté
J P
JP
Bourges-Abella
N
N
Cadot
R
R
Morel
G
G
Lambert
A M
AM
D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002074:Butanones / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005327:Fetal Resorption; D005333:Fetus; D006651:Histocytochemistry; D019570:Inhalation Exposure; D007668:Kidney / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects; D008297:Male; D008333:Mandelic Acids / Q000652:urine; D018811:Maternal Exposure; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D001555:Benzene Derivatives; D002074:Butanones; D008333:Mandelic Acids; C005222:methylethyl ketone; C004912:ethylbenzene; C037938:mandelic acid