title: Use of the sensory nerve stimulator to accelerate healing of a venous leg ulcer with sensory nerve dysfunction: a case study.
abstract: A new therapy using sensory nerve stimulation [International Patent Application Number PCT/AU2004/001079: "nerve function and tissue healing" (Khalil, Z)] has been developed in our vascular physiology laboratory. This treatment has been found to improve the deficient sensory nerve function and associated deficient wound healing of older persons to levels seen in young people. An 82-year-old man with a small but persistent venous leg ulcer for 18 months, despite apparently appropriate wound dressings and compression therapy, was seen in a specialist wound management service. The patient's sensory and microvascular function was assessed in great detail using the vascular physiology laboratory techniques, and he was provided the sensory nerve stimulation therapy in addition to conventional therapy. His wound healed after 4 weeks. We report the case here. Prior to nerve stimulation therapy, cutaneous sensation, microvascular blood flow and oxygen tension were found to be reduced near the ulcer when compared with the opposite, non ulcerated leg. After therapy, oxygen tension and microvascular blood flow had improved. This case provides further evidence that sensory nerve stimulation therapy at the stipulated parameters improves wound healing. The observation that sensory nerve function improved provides support for the notion that improvement in healing is mediated by improved nerve function.
authors.affiliation: National Ageing Research Institute, The University of Melbourne, PO Box 31, Parkville, Victoria 3052, Australia.
authors.forename: Rajna
authors.initials: R
authors.lastname: Ogrin
authors.forename: Peteris
authors.initials: P
authors.lastname: Darzins
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Khalil
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D020427:Peroneal Neuropathies / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D004561:Transcutaneous Electric Nerve Stimulation; D014647:Varicose Ulcer / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*