title: Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.
abstract: 3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.
authors.affiliation: Small Molecule Drug Discovery, Biopharma Division, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: McBride
authors.forename: Paul A
authors.initials: PA
authors.lastname: Renhowe
authors.forename: Carla
authors.initials: C
authors.lastname: Heise
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Jansen
authors.forename: Gena
authors.initials: G
authors.lastname: Lapointe
authors.forename: Sylvia
authors.initials: S
authors.lastname: Ma
authors.forename: Ramon
authors.initials: R
authors.lastname: Piñeda
authors.forename: Jayesh
authors.initials: J
authors.lastname: Vora
authors.forename: Marion
authors.initials: M
authors.lastname: Wiesmann
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Shafer
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D015394:Molecular Structure; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D007191:Indazoles; D020794:Receptor Protein-Tyrosine Kinases