Cytogenetic analysis of human oocytes remaining unfertilized after intracytoplasmic sperm injection.
Oocytes remaining unfertilized after intracytoplasmic sperm injection showed 12.0% aneuploidy (nondisjunction + unbalanced predivision), 3.4% structural aberrations, and 8.5% balanced predivision in fully karyotyped cells. However, the frequently observed complete or partial separation of chromatids, most probably caused by abortive activation, might complicate the evaluation of meiosis I-derived aneuploidy and questions the relevance of balanced predivision.
Rosenbusch
Bernd E
BE
Department of Gynecology and Obstetrics, University of Ulm, Ulm, Germany. bernd.rosenbusch@uniklinik-ulm.de
Schneider
Michael
M
D000328:Adult; D000782:Aneuploidy; D002452:Cell Count; D002842:Chromatids; D002877:Chromosomes, Human; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D007621:Karyotyping; D008540:Meiosis / Q000235:genetics*; D009865:Oocytes / Q000473:pathology*; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure