title: An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine.
abstract: Pertussis causes substantial morbidity among adolescents and adults, as well as other persons in contact with affected individuals. In the context of widespread childhood immunization, vaccination of adolescents and adults is a relatively new strategy for reducing the disease in all age groups. ADACEL is a tetanus-diphtheria-acellular pertussis combination vaccine (incorporating pertussis toxoid, filamentous hemagglutinin, pertactin and fimbriae type 2 and 3 antigens) formulated for use in adolescents and adults based on similar products designed for infants and children. ADACEL vaccine is approved for use in Australia, Canada, Germany and the USA, and has been demonstrated to induce robust immune responses and acceptable levels of reactogenicity in clinical trials. Surveillance data from Canada, where ADACEL vaccine has been used in adolescents and adults in conjunction with ongoing childhood vaccination for several years, indicate an enhanced overall reduction in pertussis disease.
authors.affiliation: University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Rochester, NY 14642, USA. michael_pichichero@urmc.rochester.edu
authors.forename: Michael E
authors.initials: ME
authors.lastname: Pichichero
authors.forename: Lisa M
authors.initials: LM
authors.lastname: DeTora
authors.forename: David R
authors.initials: DR
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D002626:Chemistry, Pharmaceutical; D004165:Diphtheria / Q000453:epidemiology / Q000517:prevention & control; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage*; D006801:Humans; D013742:Tetanus / Q000453:epidemiology / Q000517:prevention & control; D017778:Vaccines, Combined / Q000008:administration & dosage; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017778:Vaccines, Combined