Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.
We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.
Czartoski
Todd
T
Molecular Virology Laboratory, University of Washington, 960 Republican St., Seattle, WA 98195, USA.
Liu
Charlie
C
Koelle
David M
DM
Schmechel
Stephen
S
Kalus
Andrea
A
Wald
Anna
A
D015746:Abdominal Pain / Q000209:etiology; D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D024882:Drug Resistance, Viral; D005260:Female; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000209:etiology*; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D017211:Treatment Failure
D000212:Acyclovir