title: Bioreduction of aldehydes and ketones using Manihot species.
abstract: Biocatalysis constitutes an important tool in organic synthesis, especially for the preparation of chiral molecules of biological interest. A series of aliphatic and aromatic aldehydes and two ketones were reduced using plant cell preparations from Manihot esculenta and Manihot dulcis roots. The reduced products were typically obtained in excellent yields (80-96%), and with excellent enantiomeric excess (94-98%), except for vanillin. Esters, a nitrile, and an amide were also examined, but were not reduced. Preliminary conversion rate studies are reported. This is the first attempt to perform the biotransformation of carbonyl compounds using Manihot species.
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60451-970 Fortaleza-Ceara, Caixa Postal 60021, Brazil.
authors.forename: Luciana L
authors.initials: LL
authors.lastname: Machado
authors.forename: João Sammy N
authors.initials: JS
authors.lastname: Souza
authors.forename: Marcos Carlos
authors.initials: MC
authors.lastname: de Mattos
authors.forename: Solange K
authors.initials: SK
authors.lastname: Sakata
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: Telma L G
authors.initials: TL
authors.lastname: Lemos
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D002365:Manihot / Q000737:chemistry*; D010084:Oxidation-Reduction; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000447:Aldehydes; D007659:Ketones