title: Variant angina associated with bitter orange in a dietary supplement.
abstract: The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.
authors.affiliation: Division of Cardiology, Tufts-New England Medical Center, Boston, MA, USA. cgange@tufts-nemc.org
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gange
authors.forename: Christopher
authors.initials: C
authors.lastname: Madias
authors.forename: Erika M
authors.initials: EM
authors.lastname: Felix-Getzik
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Weintraub
authors.forename: N A Mark
authors.initials: NA
authors.lastname: Estes
mesh_terms: D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D019587:Dietary Supplements / Q000506:poisoning*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013578:Synephrine / Q000506:poisoning*; D014662:Vasoconstrictor Agents / Q000506:poisoning*
chemical_list: D014662:Vasoconstrictor Agents; D013578:Synephrine