title: [Review of neurobehavioral effects of alcohol-related neurodevelopmental disorder in an animal model].
abstract: Animal models had been investigated to clear the mechanism of neurobehavioral deficits caused by in-utero alcohol exposure. 5-HT1A agonist and antioxidants administration during pregnancy could attenuate in-utero alcohol-induced teratogenesis. Recently, activity-dependent neuroprotective peptides were reported to have the potential therapeutic effect for alcohol-related teratogenicity. Environmental and motor training for litters exposed to in-utero alcohol may have improve behavioral performance. We will review amelioration of fetal alcohol-related neurodevelopmental disorders in animal models from the prevention and treatment.
authors.affiliation: Basic Clinical Science and Public Health, Tokai University School of Medicine, Bouseidai, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Furuya
authors.forename: Youko
authors.initials: Y
authors.lastname: Komaki
authors.forename: Isao
authors.initials: I
authors.lastname: Okazaki
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002065:Buspirone / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D009419:Nerve Tissue Proteins / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009842:Oligopeptides / Q000627:therapeutic use; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D009842:Oligopeptides; D017366:Serotonin Receptor Agonists; C425904:davunetide; D002065:Buspirone