title: [Serum IL-1 receptor antagonist and IL-1beta in patients with Graves' opthalmopathy].
abstract: OBJECTIVE
  To investigate the mechanism of Graves' ophthalmopathy (GO) and the relationship between serum IL-1 ra and IL-1beta and the effectiveness of glucocoids in treating GO.
  
  
  METHODS
  Serum IL-1ra and IL-1beta were measured by Enzyme linked immunosorbent assay (ELISA) and Radioimmunoassay (RIA) in three groups of people, which included 20 patients with severe GO (NOSPACES> or = IV), 20 patients with Graves' disease (GD) without ophthalmopathy, and 20 healthy volunteers. Repeated measurements were undertaken in GO patients before and after glucocoids treatment to analyze the relationship between serum IL-1ra, and IL-1beta and the effectiveness of glucocoids therapy.
  
  
  RESULTS
  Before glucocoids therapy,GO patients had higher serum IL-1beta and lower IL-1ra/IL-1beta ratio. Glucocoids therapy increased serum IL-1ra and decreased IL-1beta, and thus increased the IL-1ra/IL-1beta ratio.
  
  
  CONCLUSIONS
  Patients with GO have deficiency in IL-1ra synthesis. Glucocoids therapy can stimulate IL-1ra synthesis and inhibit IL-1beta synthesis.
authors.affiliation: Gold card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xie
authors.forename: Shuang-Qing
authors.initials: SQ
authors.lastname: Li
authors.forename: Zhen-Mei
authors.initials: ZM
authors.lastname: Aa
authors.forename: Song-Quan
authors.initials: SQ
authors.lastname: Wei
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Zhao
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D049970:Graves Ophthalmopathy / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000097:blood
chemical_list: D005938:Glucocorticoids; D053583:Interleukin-1beta; D017472:Receptors, Interleukin-1; D008775:Methylprednisolone