Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study.
Millions of persons around the world are exposed to low doses of arsenic through drinking water. However, estimates of health effects associated with low-dose arsenic exposure have been extrapolated from high-dose studies. In Bangladesh, many persons have been exposed to a wide range of doses of arsenic from drinking water over a significant period of time. The authors evaluated dose-response relations between arsenic exposure from drinking water and premalignant skin lesions by using baseline data on 11,746 participants recruited in 2000-2002 for the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh. Several measures of arsenic exposure were estimated for each participant based on well-water arsenic concentration and usage pattern of the wells and on urinary arsenic concentration. In different regression models, consistent dose-response effects were observed for all arsenic exposure measures. Compared with drinking water containing <8.1 microg/liter of arsenic, drinking water containing 8.1-40.0, 40.1-91.0, 91.1-175.0, and 175.1-864.0 microg/liter of arsenic was associated with adjusted prevalence odds ratios of skin lesions of 1.91 (95% confidence interval (CI): 1.26, 2.89), 3.03 (95% CI: 2.05, 4.50), 3.71 (95% CI: 2.53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions.
Ahsan
Habibul
H
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. habibul.ahsan@columbia.edu
Chen
Yu
Y
Parvez
Faruque
F
Zablotska
Lydia
L
Argos
Maria
M
Hussain
Iftikhar
I
Momotaj
Hassina
H
Levy
Diane
D
Cheng
Zhongqi
Z
Slavkovich
Vesna
V
van Geen
Alexander
A
Howe
Geoffrey R
GR
Graziano
Joseph H
JH
D000328:Adult; D001151:Arsenic / Q000009:adverse effects* / Q000032:analysis; D001459:Bangladesh / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D012871:Skin Diseases / Q000139:chemically induced* / Q000453:epidemiology; D014881:Water Supply
D001151:Arsenic