A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms.
Both R- and S-phenylethyl alcohol of high enantiomeric purity (98%) and with a satisfactory yield (40-80%) were obtained by bioreduction of acetophenone, catalyzed by whole cells of baker's yeast.
Brzezińska-Rodak
Małgorzata
M
Department of Bioorganic Chemistry, Wrocław University of Technology, 50-370 Wrocław, 27, Wybrzeze Wyspiańskiego, Poland. malgorzata.brzezinska-rodak@pwr.wroc.pl
Zymańczyk-Duda
Ewa
E
Klimek-Ochab
Magdalena
M
Kafarski
Paweł
P
Lejczak
Barbara
B
D000098:Acetophenones / Q000378:metabolism*; D001592:Benzyl Alcohols / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D018929:Cell Culture Techniques / Q000379:methods*; D007536:Isomerism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
D000098:Acetophenones; D001592:Benzyl Alcohols; C002017:methylphenyl carbinol; C038699:acetophenone