Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
Cai
Weibo
W
Molecular Imaging Program (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.
Shin
Dong-Woon
DW
Chen
Kai
K
Gheysens
Olivier
O
Cao
Qizhen
Q
Wang
Shan X
SX
Gambhir
Sanjiv S
SS
Chen
Xiaoyuan
X
D000818:Animals; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000138:chemical synthesis; D005909:Glioblastoma / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D009842:Oligopeptides / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D045663:Quantum Dots; D013055:Spectrophotometry, Infrared / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods
D020099:Coated Materials, Biocompatible; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid