A new drug-release method using the Staudinger ligation.
Many drugs induce severe side-effects caused by their lack of selectivity. One way to overcome this problem is to design a specific system which releases a free drug in a controlled manner. Herein we describe a new way to liberate a drug from a prodrug using the Staudinger ligation as the trigger.
Azoulay
Michel
M
UMR 176 CNRS/Institut Curie, Centre de Recherche, 26 rue d'Ulm, F-75248 Paris Cedex 05, France.
Tuffin
Gérald
G
Sallem
Wafa
W
Florent
Jean-Claude
JC
D000588:Amines / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry*
D000588:Amines; D011355:Prodrugs; D004317:Doxorubicin