[Olfactory groove meningioma: correlation between clinicoradiological features and proliferative index (Mib-1)].
OBJECTIVE
The aim of this study is to correlationate demographic, radiologic features and proliferative index defined by immunohistochemical expression of Mib-1 in olfactory groove meningiomas, and to observe possible predictive factors of recurrence of this tumor.


METHODS
There were analysed demographic, clinical and radiological features of 15 patients with olfactory groove meningioma. Fifteen paraffin-embebed tumors were studied by immunohistochemical methods for the expression of proliferative index by the Mib-1.


RESULTS
There was a statistically positive correlation between tumoral and edema volumes. There was no correlation between Mib-1, tumoral volume, tumoral edema and frontal skull base abnormalities. Two cases with tumor recurrence had proliferative indices higher than the mean index.


CONCLUSIONS
Larger tumors were more susceptible to develop peritumoral edema. The proliferative índex has no positive correlation with tumoral volume, edema volumes and skull base invasion, but probably it is associated with tumoral recurrence.
Paiva Neto
Manoel Antonio de
MA
Hospital Edmundo Vasconcelos, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil. mapnpaiva@ig.com.br
Tella
Oswaldo Inácio de
OI
Herculano
Marco Antonio
MA
Stávale
João Norberto
JN
Bonatteli
Antonio Pádua Furquim
AP
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins