Monoglycosyl, diglycosyl, and dinucleoside methylenediphosphonates: direct synthesis and antiviral activity.
A direct and general access to D-glycosyl 3-, 5-, or 6-methylenediphosphonates, di-D-glycosyl 1,5-, 3,5-, 3,6-, 5,5-, or 6,6-methylenediphosphonates and dithymidine 3',5'-methylenediphosphonate is described. The method involves the one-pot alkylidenediphosphorylation of glycosyl or thymidine derivatives. No antiviral activity was detected against a panel of RNA and DNA viruses.
Grison
Claude
C
Laboratoire de Chimie Biomoléculaire, UMR CNRS 7565, Institut Nancéien de Chimie Moléculaire, Université Henri Poincaré, Nancy 1, BP 239, F-54506 Vandoeuvre-lès-Nancy, France. cgrison@univ-montp2.fr
Joliez
Stéphane
S
De Clercq
E
E
Coutrot
Philippe
P
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D011756:Diphosphates / Q000737:chemistry; D004164:Diphosphonates / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects* / Q000254:growth & development*
D000998:Antiviral Agents; D015226:Dinucleoside Phosphates; D011756:Diphosphates; D004164:Diphosphonates; C027474:methylene diphosphonate