Beta2-microglobulin, a uremic toxin with a double meaning.
beta(2)M is a strong and independent indicator of hemodialysis patient outcomes and an excellent surrogate for middle molecules, and deserves to be routinely monitored and incorporated into dialysis adequacy targets. beta(2)M has a double meaning, reflecting both dialysis efficacy in terms of solute mass transfer and patient bioactivity. The work of Ward et al. in this issue warrants a study to test the hypothesis that long daily hemodiafiltration treatment would be the optimal renal replacement modality to improve dialysis patient outcomes.
Canaud
B
B
Nephrology, Dialysis and Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France. b-canaud@chu-montpellier.fr
Morena
M
M
Cristol
J P
JP
Krieter
D
D
D001825:Body Fluid Compartments; D017583:Hemodiafiltration; D015312:Hemodialysis Solutions / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D014511:Uremia / Q000097:blood / Q000517:prevention & control*; D001613:beta 2-Microglobulin / Q000097:blood / Q000633:toxicity*
D015312:Hemodialysis Solutions; D001613:beta 2-Microglobulin