Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells.
Chen
Xuejun
X
Niyonsaba
François
F
Ushio
Hiroko
H
Nagaoka
Isao
I
Ikeda
Shigaku
S
Okumura
Ko
K
Ogawa
Hideoki
H
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D054804:Cathelicidins; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply* / Q000187:drug effects*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D048049:Extracellular Signal-Regulated MAP Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048051:p38 Mitogen-Activated Protein Kinases