Tuberous sclerosis complex complicated by pulmonary multinodular shadows.
A 41-year-old woman with a history of epilepsy was referred for multiple nodular ground-glass opacities on a chest computed tomography (CT) scan. They were initially suspected of representing atypical adenomatous hyperplasia or well-differentiated adenocarcinoma. However, the subsequent brain CT and magnetic resonance imaging (MRI) scans revealed a coarse nodular calcification and cortical tubers. A subungual fibroma was also noted. Histological examination of a video-assisted thoracoscopic lung biopsy specimen disclosed multiple nodules of type II pneumocyte hyperplasia with septal thickening. Based on all of these findings taken together, a diagnosis of tuberous sclerosis complex with multifocal micronodular pneumocyte hyperplasia (MMPH) was made.
Kamiya
Hiroyuki
H
Department of Respiratory Medicine, International Medical Center of Japan, Toyama, Tokyo.
Shinoda
Kinya
K
Kobayashi
Nobuyuki
N
Kudo
Koichiro
K
Nomura
Tomokiyo
T
Morita
Takatomo
T
Fujii
Takeshi
T
D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D008168:Lung / Q000166:cytology / Q000000981:diagnostic imaging / Q000473:pathology*; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000150:complications* / Q000601:surgery