Comparison of sirolimus versus paclitaxel eluting stents for treatment of coronary in-stent restenosis.
In patients with in-stent restenosis (ISR) inside bare metal stents, drug-eluting stents reduce the recurrence of restenosis compared with balloon angioplasty. However, few data are available about this therapeutic modality in the case of diffuse restenosis. The aim of this study was to evaluate the immediate and mid-term outcome of sirolimus- and paclitaxel-eluting stent implantation in diffuse ISR and determine the predictors of clinical and angiographic restenosis recurrence. A series of 161 consecutive patients with 194 diffuse ISR lesions (>10 mm) treated with drug-eluting stent implantation were evaluated. Major adverse cardiac events were defined as death, myocardial infarction, and the need for target lesion revascularization. During a mean follow-up of 8.2 +/- 3.4 months, the cumulative incidence of major adverse cardiac events was 19% in the SES group and 24% in the PES group (p = 0.56). Angiographic follow-up was performed in 80% of the lesions. The overall restenosis rate was 22% and was not significantly different between lesions treated with sirolimus-eluting (20%) or paclitaxel-eluting (25%, p = 0.55) stents. The incidence of restenosis was higher in diabetics (32%) than in nondiabetics (16%, odds ratio 2.5, 95% confidence interval 1.1 to 5.5, p = 0.02). By multivariate analysis, diabetes was confirmed to be the only independent predictor of recurrent restenosis (odds ratio 3.53, 95% confidence interval 1.39 to 9.02, p = 0.008). In conclusion, drug-eluting stent implantation for diffuse ISR is associated with acceptable clinical and angiographic results. The association of diffuse restenosis and diabetes mellitus is an unfavorable condition leading to a high risk of recurrence.
Airoldi
Flavio
F
San Raffaele Hospital IRCCS, Milan, Italy.
Briguori
Carlo
C
Iakovou
Ioannis
I
Stankovic
Goran
G
Biondi-Zoccai
Giuseppe
G
Carlino
Mauro
M
Chieffo
Alaide
A
Montorfano
Matteo
M
Cosgrave
John
J
Michev
Iassen
I
Rogacka
Renata
R
Sangiorgi
Giuseppe Massimo
GM
Colombo
Antonio
A
D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000453:epidemiology / Q000628:therapy*; D019992:Databases as Topic; D003920:Diabetes Mellitus / Q000453:epidemiology; D016503:Drug Delivery Systems; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care; D017239:Paclitaxel / Q000008:administration & dosage*; D012008:Recurrence; D012307:Risk Factors; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents
D007166:Immunosuppressive Agents; D017239:Paclitaxel; D020123:Sirolimus