title: Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets.
abstract: Differential pulse polarographic (DPP) and square wave polarographic (SWP) techniques were applied at hanging mercury drop electrode (HMDE) for quantitative determination of tianeptine (TIA) in tablets. The adsorptive stripping voltammetric (ASV) behavior of TIA was also studied. TIA gave a sensitive reduction peaks at -1256, -1244 and -1072 mV for DPP, SWP and ASV, respectively (versus Ag/AgCl) in Britton-Robinson buffer (B-R buffer) at pH 11. The solution conditions and instrumental parameters were optimized for the determination of TIA in tablets. Calibration plots and regression data validation, accuracy, precision, limit of detection, limit of quantitation and other aspects of analytical merit are presented.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria 21521, Egypt. azzgazy@yahoo.com
authors.forename: Azza A
authors.initials: AA
authors.lastname: Gazy
authors.forename: Hoda
authors.initials: H
authors.lastname: Mahgoub
authors.forename: Essam F
authors.initials: EF
authors.lastname: Khamis
authors.forename: Rasha M
authors.initials: RM
authors.lastname: Youssef
authors.forename: M A
authors.initials: MA
authors.lastname: El-Sayed
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000032:analysis*; D011048:Polarography / Q000379:methods*; D013607:Tablets; D013841:Thiazepines / Q000032:analysis*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013607:Tablets; D013841:Thiazepines; C050504:tianeptine