Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.
S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
Mugnaini
Claudia
C
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via De Gasperi, 2 I-53100 Siena, Italy.
Manetti
Fabrizio
F
Esté
José A
JA
Clotet-Codina
Imma
I
Maga
Giovanni
G
Cancio
Reynel
R
Botta
Maurizio
M
Corelli
Federico
F
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000528:radiation effects; D001665:Binding Sites; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase