title: Acinar cell ultrastructure after taurine treatment in rat acute necrotizing pancreatitis.
abstract: OBJECTIVE
  To evaluate the organelle-based changes in acinar cells in experimental acute necrotizing pancreatitis (ANP) after taurine treatment and the association of electron microscopic findings with histopathological changes and oxidative stress markers.
  
  
  METHODS
  The study was performed in February 2005 at Gulhane School of Medicine and Hecettepe University, Turkey. Forty-five rats were divided into 3 groups. Acute necrotizing pancreatitis was induced in groups II and III. Groups I and II were treated with saline and Group III with taurine 1000 mg/kg/day, i.p, for 48 hours. Histopathological and ultrastructural examinations were determined using one-way analysis of variance and Kruskal-Wallis tests.
  
  
  RESULTS
  Histopathologic findings improved significantly after taurine treatment. Degree of injury in rough and smooth endoplasmic reticulums, Golgi apparatus, mitochondria and nucleus of acinar cells also decreased with taurine in correlation with biochemical and histological results.
  
  
  CONCLUSIONS
  Taurine improves acinar cell organelle structure, and ultrastructural recovery in ANP reflects histological improvement.
authors.affiliation: Department of Internal Medicine, Gulhane School of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Ates
authors.forename: Mehmet R
authors.initials: MR
authors.lastname: Mas
authors.forename: Nuket
authors.initials: N
authors.lastname: Mas
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Bilgin
authors.initials: B
authors.lastname: Comert
authors.forename: Ahmet T
authors.initials: AT
authors.lastname: Isik
authors.forename: Nuran
authors.initials: N
authors.lastname: Yener
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D008297:Male; D015388:Organelles / Q000648:ultrastructure*; D018384:Oxidative Stress / Q000502:physiology; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D013654:Taurine