title: Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor.
abstract: Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides have been found to be antagonists on the human histamine-3-receptor, showing a Ki value of as low as 4 nM.
authors.affiliation: Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark. bpes@novonordisk.com
authors.forename: Bernd
authors.initials: B
authors.lastname: Peschke
authors.forename: Sonja
authors.initials: S
authors.lastname: Bak
authors.forename: Rolf
authors.initials: R
authors.lastname: Hohlweg
authors.forename: Rita
authors.initials: R
authors.lastname: Nielsen
authors.forename: Dorthe
authors.initials: D
authors.lastname: Viuff
authors.forename: Karin
authors.initials: K
authors.lastname: Rimvall
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001554:Benzene / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000577:Amides; D005663:Furans; D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; D013876:Thiophenes; D001554:Benzene; C039281:furan