title: Solid-phase microextraction of N-nitrosamines.
abstract: A method was developed for the extraction of seven N-nitrosamine compounds from water by solid-phase microextraction (SPME). The method developed requires a total analysis time of only 1.25 h for both extraction and detection (versus 3-20 h for other isolation techniques). Three gas chromatography (GC) detection systems were tested with the SPME method, nitrogen chemiluminesence detection (NCD), nitrogen-phosphorus detection (NPD) and chemical ionization mass spectrometry (CI-MS), with method detection limits (MDLs) found in the ng/L range. This method was used to analyze wastewater samples and showed excellent selectivity of extraction. The detection limits of this method for N-nitrosodimethylamine (NDMA) range from 30 to 890 ng/L as a function of detector type. The excellent selectivity of SPME in addition to the fast analysis time would make this method ideal for general surveys, wastewater analysis and laboratory studies (e.g. degradation kinetics or formation potential).
authors.affiliation: Environmental Science and Engineering Program, UCLA, School of Public Health, Charles E. Young Drive South, Box 951772, Los Angeles, CA 90095, USA. janel.grebel@yale.edu
authors.forename: Janel E
authors.initials: JE
authors.lastname: Grebel
authors.forename: Connie C
authors.initials: CC
authors.lastname: Young
authors.forename: I H Mel
authors.initials: IH
authors.lastname: Suffet
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009602:Nitrosamines / Q000302:isolation & purification*; D012492:Salts; D012680:Sensitivity and Specificity; D013696:Temperature
chemical_list: D009602:Nitrosamines; D012492:Salts