title: 14N nuclear quadrupole resonance of some sulfa drugs.
abstract: The 14N nuclear quadrupole double resonance spectra of different polymorphs of sulfanilamide, sulfadiazine, sulfamerazine and sulfamethazine have been measured and the 14N quadrupole coupling tensors have been determined. The obtained 14N spectra are compared with those of other sulfa drugs like sulfathiazole. It is shown that different polymorphs can be easily discriminated. The application of this technique for non-destructive analysis, polymorph determination and quality control in the production of pharmaceuticals is stressed.
authors.affiliation: J. Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia. robert.blinc@ijs.si
authors.forename: Robert
authors.initials: R
authors.lastname: Blinc
authors.forename: Janez
authors.initials: J
authors.lastname: Seliger
authors.forename: Aleksander
authors.initials: A
authors.lastname: Zidansek
authors.forename: Veselko
authors.initials: V
authors.lastname: Zagar
authors.forename: Fani
authors.initials: F
authors.lastname: Milia
authors.forename: Hector
authors.initials: H
authors.lastname: Robert
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D015394:Molecular Structure; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D013411:Sulfadiazine / Q000737:chemistry; D013416:Sulfamerazine / Q000737:chemistry; D013418:Sulfamethazine / Q000737:chemistry; D013424:Sulfanilamides / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D009587:Nitrogen Isotopes; D013424:Sulfanilamides; D013411:Sulfadiazine; D013418:Sulfamethazine; D013416:Sulfamerazine