Expression of the alpha1A-adrenergic receptor in schizophrenia.
The alpha1-adrenergic receptors may contribute to cognitive functions relevant to schizophrenia. Following the discovery of an association between polymorphisms in the regulatory region of the alpha1A-adrenergic receptor and schizophrenia we investigated the expression of mRNA for this receptor between schizophrenics (n=19) and controls (n=19) using a TaqMan approach in post-mortem brains. No differences were found suggesting that mRNA levels are not altered in schizophrenia. Genotypic data for the subjects found that possession of the previously associated genotypes did not convey a difference in mRNA expression suggesting that these polymorphisms do not affect the level of transcription.
Clark
Dan A
DA
Clinical Neuropharmacology (P051), Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom. dan.clark@iop.kcl.ac.uk
Mancama
Dalu
D
Kerwin
Robert W
RW
Arranz
Maria J
MJ
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000378:metabolism; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*
C547713:ADRA1A protein, human; D012333:RNA, Messenger; D018340:Receptors, Adrenergic, alpha-1