title: An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.
abstract: OBJECTIVE
  The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether these erythrocyte enzyme activities are altered in patients who have carcinoma.
  
  
  METHODS
  Cytosolic erythrocyte enzyme activities were measured in 108 cancer patients presenting with carcinoma at one of variable sites, prior to clinical treatment. These were compared with an age- and sex-matched control group of 31 healthy volunteers.
  
  
  RESULTS
  Mean (+/-SD) catalase activities did not differ significantly, i.e. 0.0035 (+/-0.0015) EU/ml in carcinoma patients vs. 0.0031 (+/-0.00075) EU/ml in controls. However, mean carbonic anhydrase activities of 204 (+/-91) EU/ml in the carcinoma patients were significantly higher than the 158 (+/-35) EU/ml in controls (P value of 0.0065).
  
  
  CONCLUSIONS
  Cytosolic erythrocyte carbonic anhydrase levels may warrant further investigation as a potential peripheral marker in cancer.
authors.affiliation: Balikesir University Faculty of Science and Literature, Department of Chemistry, Soma Street, 10100 Balikesir, Turkey. ozensoy@balikesir.edu.tr
authors.forename: Ozen
authors.initials: O
authors.lastname: Ozensoy
authors.forename: Feray
authors.initials: F
authors.lastname: Kockar
authors.forename: Oktay
authors.initials: O
authors.lastname: Arslan
authors.forename: Semra
authors.initials: S
authors.lastname: Isik
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Malcolm
authors.initials: M
authors.lastname: Lyon
mesh_terms: D000328:Adult; D002256:Carbonic Anhydrases / Q000097:blood*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D003600:Cytosol / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000201:enzymology*
chemical_list: D002374:Catalase; D002256:Carbonic Anhydrases