title: Anesthetic efficacy of bupivacaine solutions in inferior alveolar nerve block.
abstract: The purpose of this study was to compare the anesthetic efficacy of 2 bupivacaine solutions. Twenty-two volunteers randomly received in a crossover, double-blinded manner 2 inferior alveolar nerve blocks with 1.8 mL of racemic bupivacaine and a mixture of 75% levobupivacaine and 25% dextrobupivacaine, both 0.5% and with 1 : 200,000 epinephrine. Before and after the injection, the first mandibular premolar was evaluated every 2 minutes until no response to the maximal output (80 reading) of the pulp tester and then again every 20 minutes. Data were analyzed using the Wilcoxon paired test and the paired t test. No differences were found between the solutions for onset and duration of pulpal anesthesia and duration of soft tissue anesthesia (P > .05). It was concluded that the solutions have similar anesthetic efficacy.
authors.affiliation: Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, São Paulo, Brazil. volpato@fop.unicamp.br
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Volpato
authors.forename: José
authors.initials: J
authors.lastname: Ranali
authors.forename: Juliana Cama
authors.initials: JC
authors.lastname: Ramacciato
authors.forename: Patrícia Cristine
authors.initials: PC
authors.lastname: de Oliveira
authors.forename: Glaúcia Maria Bovi
authors.initials: GM
authors.lastname: Ambrosano
authors.forename: Francisco Carlos
authors.initials: FC
authors.lastname: Groppo
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001641:Bicuspid / Q000294:innervation; D002045:Bupivacaine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D018592:Cross-Over Studies; D003782:Dental Pulp / Q000294:innervation; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007536:Isomerism; D000077554:Levobupivacaine; D008046:Lip / Q000294:innervation; D008297:Male; D008340:Mandibular Nerve / Q000187:drug effects; D008875:Middle Aged; D009407:Nerve Block; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D000077554:Levobupivacaine; D002045:Bupivacaine; D004837:Epinephrine