Clonal distribution and differential occurrence of the enterotoxin gene cluster, egc, in carriage- versus bacteremia-associated isolates of Staphylococcus aureus.
The Staphylococcus aureus enterotoxin gene cluster, egc, was detected in isolates from healthy individuals and in those from patients with bacteremia. The egc genes cooccur and are slightly enriched in strains from healthy carriers (present in 63.7% of carriage-associated isolates versus 52.9% of invasive isolates; P = 0.03). Multilocus sequence typing revealed that successful staphylococcal clones usually harbor the egc locus.
van Belkum
Alex
A
Erasmus MC, University Medical Center Rotterdam, Room L-313, Department of Medical Microbiology & Infectious Diseases, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Melles
Damian C
DC
Snijders
Susan V
SV
van Leeuwen
Willem B
WB
Wertheim
Heiman F L
HF
Nouwen
Jan L
JL
Verbrugh
Henri A
HA
Etienne
Jerome
J
D016470:Bacteremia / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology*; D004269:DNA, Bacterial / Q000032:analysis; D004768:Enterotoxins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D005810:Multigene Family; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D018089:Superantigens / Q000235:genetics* / Q000276:immunology
D004269:DNA, Bacterial; D004768:Enterotoxins; D018089:Superantigens