Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.
Watkins
William J
WJ
Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. will.watkins@gilead.com
Chen
James M
JM
Cho
Aesop
A
Chong
Lee
L
Collins
Nicole
N
Fardis
Maria
M
Huang
Wei
W
Hung
Magdeleine
M
Kirschberg
Thorsten
T
Lee
William A
WA
Liu
Xiaohong
X
Thomas
William
W
Xu
Jie
J
Zeynalzadegan
Ameneh
A
Zhang
Jennifer
J
D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D063065:Organophosphonates; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid