Definitive radiotherapy for juvenile nasopharyngeal angiofibroma.
OBJECTIVE
To update our experience with definitive radiotherapy (RT) for juvenile nasopharyngeal angiofibroma (JNA).


METHODS
Twenty-two patients received definitive RT for advanced JNA between June 1975 and March 2003 and were followed from 2.0 to 30.2 years (median, 12.7 years). Total dose ranged from 30 to 36 Gy.


RESULTS
Twenty of 22 patients (91%) remained locally controlled after RT; both patients who developed a local recurrence were salvaged so that the ultimate local control rate was 100%. No patient experienced a severe complication.


CONCLUSIONS
Patients with advanced and/or recurrent JNA thought not to be amenable to complete resection with acceptable morbidity have a high likelihood of cure after RT with a low risk of complications.
McAfee
William J
WJ
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Morris
Christopher G
CG
Amdur
Robert J
RJ
Werning
John W
JW
Mendenhall
William M
WM
D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011832:Radiation Injuries; D016879:Salvage Therapy; D016896:Treatment Outcome