Variant angina associated with bitter orange in a dietary supplement.
The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.
Gange
Christopher A
CA
Division of Cardiology, Tufts-New England Medical Center, Boston, MA, USA. cgange@tufts-nemc.org
Madias
Christopher
C
Felix-Getzik
Erika M
EM
Weintraub
Andrew R
AR
Estes
N A Mark
NA
D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D019587:Dietary Supplements / Q000506:poisoning*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013578:Synephrine / Q000506:poisoning*; D014662:Vasoconstrictor Agents / Q000506:poisoning*
D014662:Vasoconstrictor Agents; D013578:Synephrine