title: Lung cancer as an immune reconstitution disease in an HIV-1 positive man receiving HAART.
abstract: A case of small-cell lung cancer with prompt worsening of the clinical course was observed in a patient with significant immune restoration after receiving effective highly active antiretroviral therapy (HAART) for seven months. Rapid and enormous enlargement of metastatic liver was the main symptom. Chest x-ray showed an enlargement of the left hilus. The patient died 22 days after the onset of the fulminant disease. We suggest that the occurrence and aggressive course of the lung cancer resulted from the development of immune reconstitution syndrome.
authors.affiliation: Department of Infectious Diseases, Wrocław Medical University, Poland. brygida@wroclaw.dialog.net.pl
authors.forename: Brygida
authors.initials: B
authors.lastname: Knysz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zalewska
authors.forename: Marta
authors.initials: M
authors.lastname: Rzeszutko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gładysz
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000276:immunology* / Q000556:secondary*; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000276:immunology*; D008207:Lymphatic Metastasis; D008297:Male; D019438:Ritonavir / Q000008:administration & dosage; D019258:Saquinavir / Q000008:administration & dosage; D015215:Zidovudine / Q000008:administration & dosage
chemical_list: D019259:Lamivudine; D015215:Zidovudine; D019258:Saquinavir; D019438:Ritonavir