[Relation between peptide YY 3-36 and dietary induced obesity resistant rats].
OBJECTIVE
To study the plasma concentration of peptide YY3 - 36 (PYY3-36) and the expression levels of PYY mRNA of ileum and colon in dietary induced obesity (DIO) and dietary induced obesity resistant (DIO-R) rats and the relation between PYY3-36 and DIO-R rats.


METHODS
Thirty-six female SD rats were randomly divided into high-fat diet group (n = 27) and chow fed control group (n = 9), after 13 weeks of either a high-fat diet or chew fed diet, the high-fat diet group was subdivided into DIO and DIO-R group according to the final body weight. Weight gain, caloric intake, the concentration of PYY3-36 and the expression levels of PYY mRNA were measured and compared.


RESULTS
The total caloric intake of DIO-R rats was lower than DIO rats (P < 0.01), while no significant difference was found between DIO-R and control rats (P > 0.05). The concentration of PYY3-36 and the expressions of PYY mRNA of ileum and colon in DIO-R rats were higher significantly than that of the DIO and control rats (P < 0.01), while no significant difference was found between DIO and control group (P > 0.05), except that PYY mRNA of ileum was advanced in DIO group (P < 0.01).


CONCLUSIONS
On the High-fat diet, SD rats showed different susceptibility to obese and energy intake, increased levels of PYY3-36 and PYY mRNA might be related to dietary induced obesity resistant.
Wang
Chong-Jian
CJ
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Yang
Nian-Hong
NH
Xu
Ming-Jia
MJ
Wu
Song-Wen
SW
Yang
Xuefeng
X
Liu
Liegang
L
Sun
Xiufa
X
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D020022:Genetic Predisposition to Disease; D007413:Intestinal Mucosa / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000235:genetics; D010446:Peptide Fragments; D019894:Peptide YY / Q000097:blood* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats; D010446:Peptide Fragments; D012333:RNA, Messenger; D019894:Peptide YY; C061785:peptide YY (3-36)