Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II).
Stereocontrolled syntheses of model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharide are described. A trisaccharide derivative (13) was prepared as a precursor and a novel and simple approach for the rational design of a glycocluster and glycodendrimer was developed, through the syntheses of the fluorescence-labeled glycocluster (2) and glycodendrimer (3).
Jin
Yuhua
Y
Kyoritsu University of Pharmacy, Tokyo, Japan.
Hada
Noriyasu
N
Oka
Junko
J
Kanie
Osamu
O
Daikoku
Shusaku
S
Kanie
Yoshimi
Y
Yamada
Haruki
H
Takeda
Tadahiro
T
D000409:Alanine / Q000737:chemistry; D029972:Bupleurum / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004365:Drugs, Chinese Herbal; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D005456:Fluorescent Dyes / Q000737:chemistry; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010368:Pectins / Q000737:chemistry* / Q000276:immunology; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000276:immunology; D014312:Trisaccharides / Q000138:chemical synthesis
D004365:Drugs, Chinese Herbal; D000939:Epitopes; D005456:Fluorescent Dyes; D011134:Polysaccharides; D014312:Trisaccharides; D010368:Pectins; D000409:Alanine