Evaluation of the central activity of hydroxydihydrocarvone.
The central effects of hydroxydihydrocarvone (HC), an analogue of several monoterpenes, were evaluated in animal models. General behavior, locomotor activity, pentobarbital-induced sleeping time, pentylenetetrazol (PTZ)-induced convulsions, and acetic acid-induced writhing were evaluated in mice. The compound caused palpebral ptosis, decreased the response to touch, and increased sedation (general behavioral profile). HC (50-200 mg/kg) caused a significant dose-dependent decrease in the spontaneous motor activity of mice. This compound (100, 200 mg/kg) potentiated the pentobarbital sleeping time, indicating a depressant action. HC also protected the mice against PTZ-induced convulsions at 400 mg/kg. In the acetic acid-induced writhing, the antinociceptive activity of HC was demonstrated with a significant dose-dependent response at a dose range of 25-400 mg/kg. The present results provide evidence that HC has significant psychopharmacologic activity with depressant effects.
de Sousa
Damião Pergentino
DP
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba. João Pessoa, Brazil.
de Sousa Oliveira
Fernando
F
de Almeida
Reinaldo Nóbrega
RN
D000700:Analgesics / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002491:Central Nervous System Agents; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009822:Oils, Volatile / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000701:Analgesics, Opioid; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D003292:Convulsants; D006993:Hypnotics and Sedatives; D039821:Monoterpenes; D009822:Oils, Volatile; C510427:hydroxydihydrocarvone; D009020:Morphine; D010424:Pentobarbital; D010433:Pentylenetetrazole