title: Synthesis of Hsp90 dimerization modulators.
abstract: The synthesis and evaluation of several chemical modulators of heat shock protein 90 (Hsp90) dimerization is presented. These agents may represent useful tools to study the importance of N-terminal dimerization and also to determine subunit interface(s) in Hsp90.
authors.affiliation: Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. chiosisg@mskcc.org
authors.forename: Gabriela
authors.initials: G
authors.lastname: Chiosis
authors.forename: Julia
authors.initials: J
authors.lastname: Aguirre
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Nicchitta
mesh_terms: D016227:Benzoquinones; D001667:Binding, Competitive / Q000187:drug effects; D019281:Dimerization; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry* / Q000187:drug effects*; D047029:Lactams, Macrocyclic; D015394:Molecular Structure; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D011809:Quinones; C001277:geldanamycin