title: Pathogenicity of fowl adenovirus isolated from gizzard erosions to immuno-suppressed chickens.
abstract: Pathogenicity of a fowl adenovirus (FAV), JM1/1 strain of serotype 1 derived from gizzard erosions of a broiler chicken, was examined to specific pathogen-free (SPF) chickens pre-treated with infectious bursal disease viruses (IBDVs) or cyclophosphamide (CY). Virulent IBDVs, classical type, were inoculated orally at 3 days of age of SPF chickens. CY was treated subcutaneously for 3 days after hatch. FAV was given orally at 30 days of age. At 40 days of age, all chickens were bled and autopsied for serology and gross observation. Gizzard lesions were ranked by the scores depending on their severities. IBDV- or CY-treated chickens showed significantly higher gizzard lesion scores than non treated birds. There were no gross lesions in any other organs except for bursal atrophy. Serologically, antibody production against FAV was highly suppressed by IBDV infection or CY treatment.
authors.affiliation: Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Muroga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Taharaguchi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ohta
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Kozo
authors.initials: K
authors.lastname: Takase
mesh_terms: D000257:Adenoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002645:Chickens; D025681:Fowl adenovirus A / Q000472:pathogenicity*; D005895:Gizzard, Avian / Q000473:pathology / Q000821:virology*; D016867:Immunocompromised Host; D009500:Neutralization Tests / Q000662:veterinary; D011201:Poultry Diseases / Q000473:pathology / Q000821:virology*; D011233:Precipitin Tests / Q000662:veterinary; D013047:Specific Pathogen-Free Organisms; D013272:Stomach Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology
chemical_list: D000914:Antibodies, Viral