Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration.
Activated virus-specific CD8 T cells remain in the lung airways for several months after influenza virus infection. We show that maintenance of this cell population is dependent upon the route of infection and prolonged presentation of viral antigen in the draining lymph nodes (DLN) of the respiratory tract. The local effects on T cell migration have been examined. We show retention of virus-specific CD8 T cells in the mediastinal lymph node (MLN) and continuing recruitment of blood-borne migrants into the lung airways during antigen presentation. These data show that antigen that is retained after pulmonary influenza virus infection controls the migratory pattern and activation state of virus-specific CD8 T cells near the site of virus amplification.
Zammit
David J
DJ
Department of Immunology, University of Connecticut Health Center, Farmington, 06032, USA.
Turner
Damian L
DL
Klonowski
Kimberly D
KD
Lefrançois
Leo
L
Cauley
Linda S
LS
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D009980:Influenza A virus / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000382:microbiology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008482:Mediastinum; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014777:Virus Diseases / Q000276:immunology*