title: Preliminary design of a Gd-NCT neutron beam based on compact D-T neutron source.
abstract: Gadolinium has been recently proposed, as neutron capture agent in NCT (Neutron Capture Therapy), due to both the nuclide high neutron capture cross section, and the remarkable selective uptake inside tumour tissue that Gd-loaded compounds, can provide. When a neutron external source is supplied, different Gd nuclear reactions, and the generated Auger electrons in particular, cause a high local energy deposition, which results in a tumour cell inactivation. Preliminary micro- as well as macrodosimetric Monte Carlo computational investigations show that the tumour-to-healthy tissue biological damage ratio is in close relation to the neutron beam energy spectrum. The results points out that the optimum neutron spectrum, to be used for Gd-NCT, seems to lie in the 1 to 10 keV energy range. In order to 'tailor' such spectra, an original, accelerator-driven, neutron source and spectrum shaping assembly for hospital-based Gd-NCT are presented and preliminary results are reported.
authors.affiliation: Energy and Environmental Conditioning Department (DITEC), University of Genova, via all'Opera Pia n, 15/a, 1-16145, Genova, Italy. cerullo@ditec.unige.it
authors.forename: N
authors.initials: N
authors.lastname: Cerullo
authors.forename: J
authors.initials: J
authors.lastname: Esposito
authors.forename: D
authors.initials: D
authors.lastname: Bufalino
authors.forename: A
authors.initials: A
authors.lastname: Mastrullo
authors.forename: L
authors.initials: L
authors.lastname: Muzi
authors.forename: S
authors.initials: S
authors.lastname: Palmerini
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy*; D003198:Computer Simulation; D005682:Gadolinium / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D017247:Neutron Capture Therapy / Q000379:methods*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D005682:Gadolinium