title: Characterization of related impurities in megestrol acetate.
abstract: Three new compounds, 17alpha-acetoxy-2,6-dimethylpregna-1,4,6-triene-3,20-dione (1), 17alpha-acetoxy-2alpha,6-dimethylpregna-4,6-diene-3,20-dione (2), 17alpha-acetoxy-6alpha-methoxylmethylpregna-4-ene-3,20-dione (3), together with five known ones, 17alpha-acetoxy-6beta-hydroxyl-6alpha-methylpregna-4-ene-3,20-dione (4), 17alpha-acetoxy-6alpha-hydroxyl-6beta-methylpregna-4-ene-3,20-dione (5), 17alpha-acetoxy-pregna-4-ene-3,6,20-trione (6), 17alpha-acetoxy-pregna-4-ene-3,20-dione (7) and 17alpha-acetoxy-6-methylene-pregna-4-ene-3,20-dione (8), were isolated and identified from the residual mother liquor of megestrol acetate. Their structures were established by spectroscopic methods. These compounds seem to be minor impurities in production of the drug megestrol acetate.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Fujiang
authors.initials: F
authors.lastname: Guo
authors.forename: Huijin
authors.initials: H
authors.lastname: Feng
authors.forename: Youfu
authors.initials: Y
authors.lastname: Wang
authors.forename: Chune
authors.initials: C
authors.lastname: Zhang
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019290:Megestrol Acetate / Q000031:analogs & derivatives / Q000032:analysis* / Q000138:chemical synthesis
chemical_list: D019290:Megestrol Acetate