title: Multiple paths to multispecificity.
abstract: The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.
authors.affiliation: Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, 20850, USA.
authors.forename: Roy A
authors.initials: RA
authors.lastname: Mariuzza
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000916:Antibody Diversity / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology*; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody / Q000276:immunology; D006801:Humans
chemical_list: D000906:Antibodies; D000941:Antigens