title: Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure.
abstract: All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocytic leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.
authors.affiliation: Carman and Ann Adams Department of Pediatrics, Division of Hematology Oncology, Children's Hospital of Michigan, Detroit, Michigan 48201, USA. mrajpurk@med.wayne.edu
authors.forename: Madhvi
authors.initials: M
authors.lastname: Rajpurkar
authors.forename: Patricia
authors.initials: P
authors.lastname: Alcasabas
authors.forename: Indulekha
authors.initials: I
authors.lastname: Warrier
authors.forename: Rudolph P
authors.initials: RP
authors.lastname: Valentini
authors.forename: Nancy
authors.initials: N
authors.lastname: Fassinger
authors.forename: Daniel A C
authors.initials: DA
authors.lastname: Frattarelli
authors.forename: Yaddanapudi
authors.initials: Y
authors.lastname: Ravindranath
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D014212:Tretinoin