title: An integrated system for genetic analysis.
abstract: BACKGROUND
  Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use.
  
  
  METHODS
  We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward.
  
  
  CONCLUSIONS
  IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. simon.fiddy@well.ox.ac.uk
authors.forename: Simon
authors.initials: S
authors.lastname: Fiddy
authors.forename: David
authors.initials: D
authors.lastname: Cattermole
authors.forename: Dong
authors.initials: D
authors.lastname: Xie
authors.forename: Xiao Yuan
authors.initials: XY
authors.lastname: Duan
authors.forename: Richard
authors.initials: R
authors.lastname: Mott
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D004247:DNA / Q000235:genetics*; D003628:Database Management Systems; D020407:Internet; D015810:Linkage Disequilibrium / Q000235:genetics*; D010375:Pedigree; D016415:Sequence Alignment / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D004247:DNA