ALDH2 promoter polymorphism has no effect on the risk for alcoholism.
OBJECTIVE
To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism.


METHODS
Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed.


RESULTS
There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms.


CONCLUSIONS
These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.
Kimura
Mitsuru
M
National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan.
Kimura
Shigeko
S
Matsushita
Sachio
S
Kashima
Haruo
H
Higuchi
Susumu
S
D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012016:Reference Values; D012306:Risk
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial