Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues.
The discovery of molecular markers to detect the precancerous state would have profound implications in the prevention of breast cancer. We report that the expression of the Polycomb group protein EZH2 increases in histologically normal breast epithelium with higher risk of developing cancer. We identify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a possible target for preventative intervention.
Ding
Lei
L
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.
Erdmann
Christine
C
Chinnaiyan
Arul M
AM
Merajver
Sofia D
SD
Kleer
Celina G
CG
D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001940:Breast / Q000166:cytology / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D000071221:Enhancer of Zeste Homolog 2 Protein; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D063151:Polycomb Repressive Complex 2; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2