title: Tandem Nazarov cyclization-michael addition sequence catalyzed by an Ir(III) complex.
abstract: The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.
authors.forename: Mesfin
authors.initials: M
authors.lastname: Janka
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Inga E
authors.initials: IE
authors.lastname: Haedicke
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Frontier
authors.forename: Richard
authors.initials: R
authors.lastname: Eisenberg