Successful vancomycin desensitization with a combination of rapid and slow infusion methods.
Vancomycin, an antibiotic to which methicillin-resistant Staphylococcus aureus (MRSA) is sensitive, frequently induces hypersensitivity reactions. Lowering the vancomycin infusion rate and/or premedicating with antihistamine effectively reduce hypersensitivity in most cases. However, vancomycin desensitization is sometimes the only way to ensure safe use. Two types of desensitization protocols have been reported, and these utilize different infusion intervals; rapid desensitization and slow desensitization. We herein report a case of vancomycin hypersensitivity with methicillin-resistant Staphylococcus aureus infection. A combination of the two desensitization protocols, rapid desensitization followed by slow desensitization, effectively inhibited the hypersensitivity reaction during vancomycin infusion, and methicillin-resistant Staphylococcus aureus was successfully eradicated.
Kitazawa
Takatoshi
T
Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Hongo.
Ota
Yasuo
Y
Kada
Nanae
N
Morisawa
Yuji
Y
Yoshida
Atsushi
A
Koike
Kazuhiko
K
Kimura
Satoshi
S
D000328:Adult; D000707:Anaphylaxis / Q000517:prevention & control; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000276:immunology*; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016106:Methicillin Resistance; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000008:administration & dosage* / Q000276:immunology*
D000900:Anti-Bacterial Agents; D014640:Vancomycin