Cisplatin-induced hypomagnesemia and cardiac dysrhythmia.
We describe a case of a patient with cisplatin-induced hypomagnesemia who suffered brief asystole during an episode of gastroenteritis. Structural heart disease was excluded. The patient achieved complete clinical recovery after short-term administration of intravenous magnesium supplementation. Cisplatin should be considered a cause of hypomagnesemic-related cardiac dysrhythmia. Magnesium deficit may increase myocardial electrical instability and thus, the risk of life-threatening arrhythmias and sudden death. Long-term serum electrolyte measurement and appropriate replacement of magnesium are recommended.
Bashir
Hamid
H
Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, USA.
Crom
Debbie
D
Metzger
Monika
M
Mulcahey
Jean
J
Jones
Debbie
D
Hudson
Melissa M
MM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D001859:Bone Neoplasms / Q000150:complications / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy / Q000209:etiology; D006323:Heart Arrest / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D012516:Osteosarcoma / Q000150:complications / Q000628:therapy; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced* / Q000188:drug therapy
D001761:Bleomycin; D003609:Dactinomycin; D004317:Doxorubicin; D003520:Cyclophosphamide; D008274:Magnesium; D002945:Cisplatin; D008727:Methotrexate