Highly enantioselective addition of Me2Zn to aldehydes catalyzed by ClCr(Salen).
High enantiomeric excesses are obtained in the addition of Me2Zn catalyzed by commercially available ClCr(Salen). Broad scope, simple procedure, room temperature, low catalyst loading are the characteristics of this new enantioselective process, which uses the rather unreactive Me2Zn. Enantiomeric excesses in the range of 71-99% are obtained with all the aldehydes tested.
Cozzi
Pier Giorgio
PG
Dipartimento di Chimica, University of Bologna, G. Ciamician, via Selmi 2, 40126 Bologna, Italy. piergiorgio.cozzi@unibo.it
Kotrusz
Peter
P