Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma.
This study further elucidates the roles of selected chemokines (IP-10, MIG, and RANTES) and their receptors (CCR3, CCR5, and CXCR3) in asthma. We compared their profiles in six groups of participants-atopic cohort and nonatopic cohort (each including controls and asthmatic patients with or without steroid therapy). Plasma concentration of IP-10 was significantly lower while that of RANTES and the expression of CCR3 were higher in asthmatic patients (all p < 0.05). Plasma RANTES correlated positively with the GINA severity score in all asthmatic patients (r=0.27, p < 0.05), and with IL-13 in nonatopic asthmatic patients (r=0.46, p < 0.05). In asthmatic patients, the ex vivo release of IP-10 and MIG was attenuated in PBMC activated with allergen, mitogens and IL-18 (p < 0.05). In conclusion, plasma RANTES may be a surrogate marker for asthma and the diminished Th1 related CXC chemokine production may contribute to Th2 predominance in asthma.
Lun
Samantha W M
SW
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
Wong
C K
CK
Ko
Fanny W S
FW
Ip
W K
WK
Hui
David S C
DS
Lam
Christopher W K
CW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D039741:Antigens, Dermatophagoides / Q000276:immunology / Q000494:pharmacology; D060829:Arthropod Proteins; D001249:Asthma / Q000097:blood / Q000276:immunology*; D001562:Benzimidazoles / Q000097:blood / Q000276:immunology / Q000494:pharmacology; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000276:immunology; D019742:Chemokines, CC / Q000096:biosynthesis* / Q000276:immunology; D019743:Chemokines, CXC / Q000096:biosynthesis* / Q000276:immunology; D003546:Cysteine Endopeptidases; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000276:immunology / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D019707:Receptors, Chemokine / Q000096:biosynthesis* / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D039741:Antigens, Dermatophagoides; D060829:Arthropod Proteins; D001562:Benzimidazoles; D018946:Chemokine CCL5; D019742:Chemokines, CC; D019743:Chemokines, CXC; D020382:Interleukin-18; C485230:N,N'-bis(2-amino-1-benzylbenzimidazol-3-yl)-1,12-dodecane; D019707:Receptors, Chemokine; D003546:Cysteine Endopeptidases; C451162:Dermatophagoides pteronyssinus antigen p 1