title: [A study of chromosomal fragility in peripheral blood lymphocytes in patients with lymphomas].
abstract: Patients with lymphomas were shown to have authentically a higher frequency of fragile sites, both spontaneous and induced by aphidikoline expression, in comparison with the control group. Differential sensitivity of chromosomes caused by the action of aphidikolin was revealed. The fragility of chromosomes 9 and 11 in patients with lymphomas on sites 9q31-32 and 11p13-14 was authentically higher (alpha = 0.05) than that in healthy individuals. Site 9q31-32 appeared to be strictly specific for lymphoma disease.
authors.forename: O V
authors.initials: OV
authors.lastname: Mikhaĭlovskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Viktorova
authors.forename: O R
authors.initials: OR
authors.lastname: Krasnova
authors.forename: A A
authors.initials: AA
authors.lastname: Titova
authors.forename: S N
authors.initials: SN
authors.lastname: Koliubaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D016590:Aphidicolin / Q000494:pharmacology; D002873:Chromosome Fragility; D002877:Chromosomes, Human / Q000235:genetics; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D016590:Aphidicolin