title: Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
abstract: Neuronal migration and axon guidance constitute fundamental processes in brain development that are generally studied independently. Although both share common mechanisms of cell biology and biochemistry, little is known about their coordinated integration in the formation of neural circuits. Here we show that the development of the thalamocortical projection, one of the most prominent tracts in the mammalian brain, depends on the early tangential migration of a population of neurons derived from the ventral telencephalon. This tangential migration contributes to the establishment of a permissive corridor that is essential for thalamocortical axon pathfinding. Our results also demonstrate that in this process two different products of the Neuregulin-1 gene, CRD-NRG1 and Ig-NRG1, mediate the guidance of thalamocortical axons. These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain.
authors.affiliation: Instituto de Neurociencias de Alicante, CSIC & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: Guillermina
authors.initials: G
authors.lastname: López-Bendito
authors.forename: Aline
authors.initials: A
authors.lastname: Cautinat
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Sánchez
authors.forename: Franck
authors.initials: F
authors.lastname: Bielle
authors.forename: Nuria
authors.initials: N
authors.lastname: Flames
authors.forename: Alistair N
authors.initials: AN
authors.lastname: Garratt
authors.forename: David A
authors.initials: DA
authors.lastname: Talmage
authors.forename: Lorna W
authors.initials: LW
authors.lastname: Role
authors.forename: Patrick
authors.initials: P
authors.lastname: Charnay
authors.forename: Oscar
authors.initials: O
authors.lastname: Marín
authors.forename: Sonia
authors.initials: S
authors.lastname: Garel
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001692:Biological Transport; D019556:COS Cells; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D002522:Chlorocebus aethiops; D066246:ErbB Receptors / Q000172:deficiency; D045888:Ganglion Cysts / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D020890:Neuregulin-1 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D066247:Receptor, ErbB-4; D013687:Telencephalon / Q000166:cytology; D013788:Thalamus / Q000166:cytology* / Q000378:metabolism
chemical_list: D020890:Neuregulin-1; D020033:Protein Isoforms; D012333:RNA, Messenger; D066246:ErbB Receptors; C587690:Erbb4 protein, mouse; D066247:Receptor, ErbB-4