Effect of Solanum lycocarpum St. Hill on various haematological parameters in diabetic rats.
Solanum lycocarpum St. Hill (SL) is commonly used in Brazilian folk medicine. The aim of the present study was to evaluate the validity of the traditional therapeutic indication of SL as hypoglycaemic agent. The extract reduced glycemia to 92.4mg/dl in alloxan induced diabetic rats (230.5mg/dl). We also investigated the potential of SL as antioxidant (it reduced in 27% nitrate generation in diabetic animals). Our results also demonstrated that SL is not ulcerogenic and restored haemoglobin and haematocrit to normal values in diabetic animals.
Perez
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AC
Department of Pharmacology, UFMG (Federal University of Minas Gerais), Brazil. acp@icb.ufmg.br
Franca
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Daldegan
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Duarte
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ID
D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009566:Nitrates / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D032322:Solanum
D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009566:Nitrates; D010936:Plant Extracts; D000496:Alloxan