title: [Study on unrelated donor allogeneic bone marrow transplantation with Bu-CY2 conditioning regimen for myelodysplastic syndrome].
abstract: To evaluate the efficacy and safety of Bu-CY(2) conditioning regimen on allogeneic bone marrow transplantation (BMT) with unrelated donor for myelodysplastic syndrome.
  
  
  
  Six patients received chemotherapy regimen of busulfan (Bu) and cyclophosphamide (CY) before allogeneic BMT (Bu 4 mg . kg(-1) . d(-1), -7 d - -4 d, CY 60 mg . kg(-1) . d(-1), -3 d - -2 d). Mycophenolate mofetil combined with cyclosporin A and methotrexate was used for prevention of acute graft-versus-host disease after transplantation. Lipo prostaglandin E(1)was used in prophylactic regimen for hepatic veno-occlusive disease.
  
  
  
  Neutrophil count began to be higher than 0.5 x 10(9)/Lat the 18th day after BMT. Platelet count began to be higher than 20 x 10(9)/Lat the 21st day after BMT. Disease-free survival in the six patients was 27 months.
  
  
  
  Bu-CY(2) conditioning regimen on allogeneic bone marrow transplantation with unrelated donor is an effective therapy for patients with myelodysplastic syndrome.
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Ji-min
authors.initials: JM
authors.lastname: Shi
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cai
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiu-jin
authors.initials: XJ
authors.lastname: Ye
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jing-song
authors.initials: JS
authors.lastname: He
authors.forename: Wan-zhuo
authors.initials: WZ
authors.lastname: Xie
authors.forename: Wei-yan
authors.initials: WY
authors.lastname: Zheng
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Meng
authors.forename: Mao-fang
authors.initials: MF
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000601:surgery*; D019172:Transplantation Conditioning
chemical_list: D003520:Cyclophosphamide; D002066:Busulfan