MR susceptometry for measuring global brain oxygen extraction.
Monitoring of oxygen saturation in jugular venous blood gives an estimate of the balance of global oxygen delivery and cerebral oxygen consumption. We present a noninvasive approach to measure oxygen saturation in vivo in the internal jugular vein using MR susceptometry by exploiting the characteristic susceptibility of deoxyhemoglobin, and demonstrate the feasibility of performing such measurements in a group of subjects. We assessed the sensitivity of the method for detecting small changes in oxygen saturation by monitoring the variations observed during breath-holding and hypoventilation experiments. Unlike alternative methods, the susceptometric technique does not require calibration.
Fernández-Seara
María A
MA
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.
Techawiboonwong
Aranee
A
Detre
John A
JA
Wehrli
Felix W
FW
D001921:Brain / Q000378:metabolism*; D005240:Feasibility Studies; D006801:Humans; D007601:Jugular Veins / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D010100:Oxygen