title: Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension: a case report and review of the literature.
abstract: Spontaneous rupture is a rare complication of splenic hamartoma. A review of the literature revealed only four such cases. To the best of our knowledge, this is the first report of spontaneous rupture of splenic hamartoma associated with liver cirrhosis and portal hypertension. A 53-year-old woman, who was followed up for aortic dissection and hepatitis C virus (HCV)-related liver cirrhosis, was referred with sudden left chest and shoulder pain. An abdominal ultrasound showed intraabdominal bleeding, and computed tomography indicated rupture of a splenic tumor. Emergent splenectomy was carried out. The postoperative course was uneventful, and the patient was discharged on the 13th postoperative day. Pathology revealed the tumor to be a ruptured splenic hamartoma. The non-tumorous splenic parenchyma revealed congestive changes. We consider that the presence of liver cirrhosis and portal hypertension are risk factors for spontaneous rupture of the splenic hamartoma.
authors.affiliation: Department of Surgery, Asahi General Hospital, I-1326, Asahi City, Chiba 289-2511, Japan. seyamay-sur@h.u-tokyo.ac.jp
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Seyama
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Motoki
authors.initials: M
authors.lastname: Nagai
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Furuya
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nomura
authors.forename: Jimpei
authors.initials: J
authors.lastname: Ishii
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nobori
mesh_terms: D005260:Female; D006222:Hamartoma / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000150:complications*; D008875:Middle Aged; D012422:Rupture, Spontaneous / Q000209:etiology*; D013158:Splenic Diseases / Q000150:complications*