Malignant solid and pseudopapillary tumor of the pancreas--clinicohistological, immunohistochemical, and flow cytometric evaluation.
OBJECTIVE
Solid and pseudopapillary tumor of the pancreas is a benign and low malignant potential tumor. Prognosis is good after surgical resection but its malignant potential is usually defined after metastasis. We compared benign and malignant cases with clinicopathological, immunohistochemical and DNA flow cytometric studies.


METHODS
From January 1991 to July 2004, seven patients were found to have solid and pseudopapillary tumor of the pancreas at Taipei Veterans General Hospital. The paraffin sections were reevaluated with hematoxylin & eosin stain, immunohistochemical stains, and DNA flow cytometric studies.


RESULTS
It included 6 benign and one malignant case. The progesterone receptor, vimentin, neuron-specific enolase, and chromogranin A showed diffused positive stain in all cases. Estrogen receptor and P53 stain were negative in all 7 patients. Synaptophysin stain was negative in 6 no recurrence patients, but was positive only in the patient who suffered from recurrence. DNA flow cytometry showed diploid results in six non-malignant tumors. In the malignant patient, the tumor in the first operation showed diploid result, but tumors in second and third operations showed aneuploidy.


CONCLUSIONS
Solid and pseudopapillary tumor of the pancreas should be considered as a potentially malignant disease in all patients and regular follow-up is mandatory.
Lai
Hung-Wen
HW
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital National Yang Ming University, Taiwan.
Su
Cheng-Hsi
CH
Li
Anna Fen-yau
AF
Wu
Li-Hwa
LH
Shyr
Yi-Ming
YM
Chen
Tien-Hua
TH
Wu
Chew-Wun
CW
Lui
Wing-Yui
WY
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D018292:Cystadenoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011003:Ploidies; D011987:Receptors, Steroid / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D014408:Biomarkers, Tumor; D011987:Receptors, Steroid; C043392:SERPINA1 protein, human; D016159:Tumor Suppressor Protein p53; D014746:Vimentin; D000515:alpha 1-Antitrypsin; D010751:Phosphopyruvate Hydratase