Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen.
In this report, we show that the Chlamydia trachomatis-specific CD8+ T cell antigen class I accessible protein-1 (Cap1) is expressed during the early stages of the C. trachomatis developmental cycle. We provide additional evidence suggesting that Cap1 may be important in early immune recognition of the organism. Understanding the temporal and spatial expression of CD8+ T cell antigens such as Cap1 may be beneficial in designing multisubunit vaccines to stimulate a vigorous immune response against C. trachomatis.
Balsara
Zarine R
ZR
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Roan
Nadia R
NR
Steele
Lisa N
LN
Starnbach
Michael N
MN
D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002690:Chlamydia Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012329:RNA, Bacterial / Q000032:analysis
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; C423325:Cap1 protein, Chlamydia trachomatis; D008565:Membrane Proteins; D012329:RNA, Bacterial; D007371:Interferon-gamma