title: Novel serum inflammatory markers in patients with adnexal mass who had surgery for ovarian torsion.
abstract: OBJECTIVE
  To determine the diagnostic value of preoperative levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and E-selectin in patients with an adnexal mass who had surgery for ovarian torsion.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Fifty consecutive women with adnexal mass who were admitted with a diagnosis of ovarian torsion.
  
  
  METHODS
  All had a single preoperative measurement of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA.
  
  
  METHODS
  To determine if a single preoperative serum sampling of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA can diagnose ovarian torsion.
  
  
  RESULTS
  Thirteen patients had proven torsion of the ovary. Serum levels of IL-6 were significantly higher in the 13 patients with proven ovarian torsion compared with the 37 without ovarian torsion. Patients with IL-6 serum values > or =10.2 pg/mL had a 16 times higher risk of having ovarian torsion. No significant difference was found in TNF-alpha, IL-8, and E-selectin between the two groups.
  
  
  CONCLUSIONS
  The IL-6 levels might assist in the prompt diagnosis of ovarian torsion and allow a timely surgical intervention.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital of Larissa, Larissa, Greece. dapontea@otenet.gr
authors.forename: Alexandros
authors.initials: A
authors.lastname: Daponte
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.forename: Christos
authors.initials: C
authors.lastname: Hadjichristodoulou
authors.forename: Georgios
authors.initials: G
authors.lastname: Lialios
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kallitsaris
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Maniatis
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Messinis
mesh_terms: D000291:Adnexal Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014102:Torsion Abnormality / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000601:surgery
chemical_list: D015415:Biomarkers; D016207:Cytokines