title: [CranioNet -- an interdisciplinary strategy for craniopharyngioma].
abstract: In patients with craniopharyngioma, pituitary failure and often lifelong hormone replacement therapy, persisting ophthalmological problems with impaired vision, cranial nerve palsies, and psychoneurological deficits will lead to a persisting impairment in quality of life and social competence. Some patients completely depend on assistance. To prevent this, a major goal is an early diagnosis and limitation of operative radicality to minimize postoperative complications. Surgery in centers with special expertise is mandatory. Radiotherapeutical strategies are relatively safe and improve the outcome and recurrence-free survival after incomplete surgical resection or after local recurrence. Multidisciplinary concepts and prospective data acquisition are desirable with regard to therapy and outcome in patients with craniopharyngioma. Problems in the follow-up period are the development of atherosclerotic complications and metabolic syndrome as a consequence of occasionally excessive obesity, which may impair the long-term survival of the patients. Cause and progression of these complications are not fully understood, therapeutical strategies for the morbid obesity are not available. Only interdisciplinary co-operation will help to develop and evaluate therapeutical concepts for the management of this rare disease.
authors.affiliation: Klinik für Endokrinologie und Stoffwechselkrankheiten, Otto-von-Guericke Universität Magdeburg. kirsten.reschke@medizin.uni-magdeburg.de
authors.forename: K
authors.initials: K
authors.lastname: Reschke
authors.forename: S
authors.initials: S
authors.lastname: Busse
authors.forename: K
authors.initials: K
authors.lastname: Mohnike
authors.forename: M
authors.initials: M
authors.lastname: Buchfelder
authors.forename: M
authors.initials: M
authors.lastname: Ranke
authors.forename: R
authors.initials: R
authors.lastname: Fahlbusch
authors.forename: H
authors.initials: H
authors.lastname: Lehnert
mesh_terms: D003131:Combined Modality Therapy; D003266:Continuity of Patient Care; D003397:Craniopharyngioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome