Rational design of new polymerizable oxyanion receptors.
We report the synthesis of a library of new polymerizable functional monomers designed for complexing with the oxyanionic moiety of the chemotherapeutic drug methotrexate. The 1H NMR and ITC binding studies allowed for the selection of receptors possessing the best association parameters. Subsequently, the design of a broad library of polymerizable moiety-specific binding monomers for the imprinting of dicarboxylate containing drugs was accomplished. Di(ureidoehylenemethacrylate)stilbene possesses the highest association properties and shows potential to act as a monomer in the molecularly imprinting technique to obtain photoswitchable cavities.
Gomy
Christophe
C
Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7, Canada.
Schmitzer
Andreea R
AR