title: ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.
abstract: Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.
authors.affiliation: Department of Pediatrics, Hospital Farhat Hached, Sousse, Tunisia. thabetfarah@yahoo.fr
authors.forename: Farah
authors.initials: F
authors.lastname: Thabet
authors.forename: Rim
authors.initials: R
authors.lastname: Sghiri
authors.forename: Brahim
authors.initials: B
authors.lastname: Tabarki
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Ghedira
authors.forename: Moncef
authors.initials: M
authors.lastname: Yacoub
authors.forename: Ahmed Sahloul
authors.initials: AS
authors.lastname: Essoussi
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D002648:Child; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000276:immunology; D013889:Thiouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013889:Thiouracil; C019269:benzylthiouracil