Gabapentin-induced coma in a patient with renal failure.
We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.
Dogukan
Ayhan
A
Divison of Nephrology, Firat University, Elazig, Turkey. aydogukan@hotmail.com
Aygen
Bilge
B
Berilgen
Muhammed S
MS
Dag
Sait
S
Bektas
Sevim
S
Gunal
Ali I
AI
D000284:Administration, Oral; D000588:Amines / Q000009:adverse effects* / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced* / Q000503:physiopathology; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D018570:Risk Assessment; D012585:Sciatica / Q000188:drug therapy* / Q000209:etiology; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin