[Study of paroxysmal kinesigenic dyskinesia with fMRI].
To detect the differences in subcortical structures between patients with paroxysmal kinesigenic dyskinesia (PKD) and normal subjects during movement preparation and execution.



The PKD patients performed a movement task, in which a CUE signal (preparation) indicated the movement sequence prior to the appearance of an imperative GO signal (execution). Event-related functional magnetic resonance imaging (fMRI) and 3dDeconvolve program of AFNI were used to estimate the hemodynamic response function and to generate activation maps.



During movement preparation, the activated brain areas in PKD patients were less than those of normal subject, and there was no activation in basal ganglia in PKD patients. During execution, the activation was also less in PKD patients except in bilateral M1.



During intermission, abnormalities of the brain still exist in PKD patients when during preparing or performing movement. The movement circuit in the brain displays an unusual state. The attack may be caused by reducing of inhibition in brain areas.
Zhu
Yi-hong
YH
College of Medicine, Zhejiang University, Hangzhou 310006, China. rhzhu@hzcnc.com
Luo
Ben-yan
BY
Ruan
Ling-xiang
LX
Wang
Mei-hao
MH
Li
Jian-ce
JC
Weng
Xu-chu
XC
Chen
Yi-zhang
YZ
D000328:Adult; D002819:Chorea / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D009068:Movement / Q000502:physiology*