Effect of coenzyme Q(10) supplementation in the rat model of adjuvant arthritis.
Adjuvant arthritis (AA) is a model of chronic inflammation induced by Mycobacterium butyricum and characterized by similar pathophysiological and pathobiochemical changes as rheumatoid arthritis (RA) in humans. In this study the antirheumatic activity of coenzyme Q(10) supplementation was tested not only as to its capability to suppress the inflammation edema of the hind paw and to improve the body weight of the arthritic animals, but also to improve so important biochemical parameters as markers of inflammation and oxidative stress, and of mitochondrial bioenergetics. Despite the unfavorable effects on the rheumatic processes observed by monitoring biometric parameters (hind paw volume, relative body weight, relative weight of spleen), a significant protective effect was observed on the level of mitochondrial energetic and antioxidant disbalance. This finding speaks in favor of CoQ(10) supplementation in rheumatic patients, presumably as combinatory therapy with classical antirheumatics, e.g. NSAIDs.
Bauerova
Katarina
K
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. Katarina.Bauerova@savba.sk
Kucharska
Jarmila
J
Mihalova
Danica
D
Navarova
Jana
J
Gvozdjakova
Anna
A
Sumbalova
Zuzana
Z
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D014451:Ubiquinone / Q000627:therapeutic use*
D014451:Ubiquinone