SOCS proteins and caveolin-1 as negative regulators of endocrine signaling.
Recently, a new class of regulatory molecules has emerged; these molecules, termed SOCS proteins, function as suppressors of cytokine signaling. SOCS proteins negatively regulate the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling cascade. Interestingly, it appears that other proteins, such as caveolin-1, can also function as suppressors of cytokine signaling by inhibiting the kinase activity of JAK family members. This might result from the ability of caveolin-1 to function as a broad-spectrum kinase inhibitor through the caveolin-scaffolding domain.
Jasmin
Jean-François
JF
Departments of Molecular Pharmacology and Medicine, The Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Mercier
Isabelle
I
Sotgia
Federica
F
Lisanti
Michael P
MP
D000818:Animals; D051242:Caveolin 1 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D003920:Diabetes Mellitus; D016147:Genes, Tumor Suppressor; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006967:Hypersensitivity; D007249:Inflammation; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D053616:Janus Kinase 3; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D050791:STAT Transcription Factors / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000502:physiology*; D050826:Suppressor of Cytokine Signaling Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D051242:Caveolin 1; D006728:Hormones; D011518:Proto-Oncogene Proteins; D050791:STAT Transcription Factors; D050826:Suppressor of Cytokine Signaling Proteins; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; C507924:JAK2 protein, human; C507933:JAK3 protein, human; C507905:Jak1 protein, mouse; C507926:Jak2 protein, mouse; C507935:Jak3 protein, mouse; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D053616:Janus Kinase 3