title: Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina.
abstract: The filamentous fungus Podospora anserina has a limited lifespan. In this organism, aging is systematically associated to mitochondrial DNA instability. We recently provided evidence that the respiratory function is a key determinant of its lifespan. Loss of function of the cytochrome pathway leads to the compensatory induction of an alternative oxidase, to a decreased production of reactive oxygen species and to a striking increase in lifespan. These changes are associated to the stabilization of the mitochondrial DNA. Here we review and discuss the links between these different parameters and their implication in the control of lifespan. Since we demonstrated the central role of mitochondrial metabolism in aging, the same relationship has been evidenced in several model systems from yeast to mice, confirming the usefulness of simple organisms as P. anserina for studying lifespan regulation.
authors.affiliation: Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Lorin
authors.forename: Eric
authors.initials: E
authors.lastname: Dufour
authors.forename: Annie
authors.initials: A
authors.lastname: Sainsard-Chanet
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D019069:Cell Respiration / Q000502:physiology; D003580:Cytochromes / Q000378:metabolism; D004271:DNA, Fungal / Q000502:physiology; D004272:DNA, Mitochondrial / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D048468:Podospora / Q000378:metabolism / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013045:Species Specificity; D013997:Time Factors
chemical_list: D003580:Cytochromes; D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D005656:Fungal Proteins; D017382:Reactive Oxygen Species; D010088:Oxidoreductases