title: ESCRT complexes assembled and GLUEd.
abstract: The ESCRT-I, -II, and -III complexes act sequentially to sort monoubiquitinated transmembrane proteins into multivesicular bodies for targeted degradation in the lysosome. Two papers published in a recent issue of Cell provide insights into the structural organization and functional interactions of the ESCRT-I complex and ESCRT-II GLUE domain.
authors.forename: Sudharshan
authors.initials: S
authors.lastname: Eathiraj
authors.forename: David G
authors.initials: DG
authors.lastname: Lambright
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008954:Models, Biological; D008957:Models, Genetic; D008958:Models, Molecular; D008968:Molecular Conformation; D018129:Phosphatidylinositol Phosphates / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D025801:Ubiquitin / Q000737:chemistry
chemical_list: D018129:Phosphatidylinositol Phosphates; D025801:Ubiquitin; C055525:phosphatidylinositol 3-phosphate