Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study.
A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child Health and Human Development, to compare the family history of autoimmune disorders in children with ASD with and without a history of regression. A history of regression was determined from the results of the Autism Diagnostic Interview-Revised (ADI-R). Family history of autoimmune disorders was obtained by telephone interview. Regression was significantly associated with a family history of autoimmune disorders (adjusted OR=1.89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41).
Molloy
Cynthia A
CA
Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229-3039, USA. cynthia.molloy@cchmc.org
Morrow
Ardythe L
AL
Meinzen-Derr
Jareen
J
Dawson
Geraldine
G
Bernier
Raphael
R
Dunn
Michelle
M
Hyman
Susan L
SL
McMahon
William M
WM
Goudie-Nice
Julie
J
Hepburn
Susan
S
Minshew
Nancy
N
Rogers
Sally
S
Sigman
Marian
M
Spence
M Anne
MA
Tager-Flusberg
Helen
H
Volkmar
Fred R
FR
Lord
Catherine
C
D001321:Autistic Disorder / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D012043:Regression, Psychology; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000235:genetics / Q000523:psychology