[The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease].
OBJECTIVE
To investigate the correlation between intercellular adhesion molecule1 (ICAM1) gene K469E polymorphism and coronary heart disease(CHD) in Han Chinese population.


METHODS
Using the methods of polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP), 173 CHD patients and 141 controls were analyzed for the polymorphism, genotype and allele distribution of ICAM1 gene K469E.


RESULTS
The distribution of ICAM1 genotypes was in Hardy-Weinberg equilibrium. The frequency of KK genotype in CHD group was significantly higher than that in control (64.2% vs 48.9%, P<0.01). Similarly, the frequency of K allele in CHD group was significantly higher than that in control (79.2% vs 69.9%, P<0.01). With Logistic Regression Analysis ruling out the influences of age, gender and other CHD risk factor, the homozygous individual with KK genotype was 2.35 folds of KE or EE genotype one suffering from CHD (OR: 2.35, 95%CI: 1.03-5.36, P<0.05).


CONCLUSIONS
ICAM1 gene K469E polymorphism is associated with CHD risk of Han Chinese population, the K allele may serve as a genetic risk factor of coronary heart disease.
Zhang
Shun-rong
SR
Department of Cardiovascular Medicine, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027 P.R.China.
Xu
Li-xin
LX
Gao
Qiu-qi
QQ
Zhang
Huai-qin
HQ
Xu
Bing-sen
BS
Lin
Jie
J
Huang
Wei-jian
WJ
D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors
D018799:Intercellular Adhesion Molecule-1