Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo.
Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA(PAM)). We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro.
Haase
Rikke N
RN
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Denmark.
Megnekou
Rosette
R
Lundquist
Maja
M
Ofori
Michael F
MF
Hviid
Lars
L
Staalsoe
Trine
T
D000818:Animals; D000953:Antigens, Protozoan / Q000502:physiology*; D016466:CHO Cells; D045744:Cell Line, Tumor; D002822:Choriocarcinoma / Q000469:parasitology; D006224:Cricetinae; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology*; D010920:Placenta / Q000469:parasitology; D010963:Plasmodium falciparum / Q000276:immunology / Q000502:physiology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology*; D014594:Uterine Neoplasms / Q000469:parasitology
D000953:Antigens, Protozoan