title: Dynamic airflow limitation after topical anaesthesia of the upper airway.
abstract: This prospective before-and-after observational study investigated the effect of upper airway anaesthesia on dynamic airflow. Six consenting ASA 1 adults, all authors of this study, underwent a series of spirometric measurements before and after topical anaesthesia of the upper airway using lignocaine. Peak inspiratory flow rate, forced inspiratory flow between 25% and 75% of the maximum inhaled volume, forced expiratory volume at 1 second, and forced vital capacity in the supine and sitting positions were measured. The measured inspiratory parameters were significantly reduced after lignocaine topical anaesthesia of the upper airway. Expiratory flow parameters were not affected. We conclude that topical anaesthesia of the upper airway leads to dynamic inspiratory airflow limitation.
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong S.A.R., P R C.
authors.forename: A M H
authors.initials: AM
authors.lastname: Ho
authors.forename: D C
authors.initials: DC
authors.lastname: Chung
authors.forename: M K
authors.initials: MK
authors.lastname: Karmakar
authors.forename: C D
authors.initials: CD
authors.lastname: Gomersall
authors.forename: Z
authors.initials: Z
authors.lastname: Peng
authors.forename: B A
authors.initials: BA
authors.lastname: Tay
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000402:Airway Obstruction / Q000139:chemically induced*; D000704:Analysis of Variance; D000758:Anesthesia / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D013147:Spirometry; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine