Interaction between BRCA1 and human papilloma virus E7: an ontology study.
BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. Recent studies indicate that BRCA 1 interacts with and regulates the activity of estrogen receptor alpha. The correlation between BRCA1 and E7 of papilloma virus becomes a new interesting topic in gynecological cancer. According to this study, E7 can add no function or aberration to the BRCA1 molecule. Further experimental studies are needed before making a conclusion on this topic. The finding in this study not only supports the previous knowledge on BRCA1 but also gives a new view on the function of BRCA1 and E7 in breast cancer. Here, the author used a new gene ontology technology to predict the molecular function and biological process of BRCA1 and E7.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. wviroj@pioneer.netserv.chula.ac.th
D000595:Amino Acid Sequence; D019313:BRCA1 Protein / Q000502:physiology*; D001943:Breast Neoplasms / Q000235:genetics; D030541:Databases, Genetic; D005260:Female; D015870:Gene Expression; D019398:Genes, BRCA1; D006801:Humans; D050725:Papillomavirus E7 Proteins / Q000235:genetics / Q000502:physiology*
D019313:BRCA1 Protein; D050725:Papillomavirus E7 Proteins