title: Triploidy formation after intracytoplasmic sperm injection may be a surrogate marker for implantation.
abstract: OBJECTIVE
  Triploidy after intracytoplasmic sperm injection (ICSI) is due mostly to retention of the second polar body. Our interest was to determine the predictors of triploidy and to determine whether the presence of triploidy can serve as a surrogate marker of implantation for the remaining cohort of zygotes.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Academic research center.
  
  
  METHODS
  Infertile couples undergoing IVF/ICSI.
  
  
  METHODS
  None.
  
  
  METHODS
  Triploid zygote (3PN) rate, implantation rate.
  
  
  RESULTS
  The 3PN rate is a significant predictor of implantation rate for the remaining cohort of zygotes. The starting and total dose of gonadotropins administered and the total days of stimulation are independent predictors of the 3PN rate.
  
  
  CONCLUSIONS
  In couples with a normal semen analysis undergoing IVF/ICSI, the 3PN rate may serve as a surrogate marker of oocyte quality and may be altered by adjusting the stimulation protocol.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA.
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Rosen
authors.forename: Shehua
authors.initials: S
authors.lastname: Shen
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Dobson
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Fujimoto
authors.forename: Charles E
authors.initials: CE
authors.lastname: McCulloch
authors.forename: Marcelle I
authors.initials: MI
authors.lastname: Cedars
mesh_terms: D000328:Adult; D015415:Biomarkers; D015331:Cohort Studies; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011003:Ploidies; D011237:Predictive Value of Tests; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors; D015053:Zygote / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D015415:Biomarkers