The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau-Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep.
Epilepsy with continuous spike- and -waves during slow-wave sleep and Landau-Kleffner syndrome are two rare childhood epilepsy syndromes. The underlying pathophysiology remains unknown. The current opinions about epidemiologic risk factors, genetic predisposition, EEG and MEG findings, influence of anti-epileptic drugs, neuroradiology, positron emission tomopgraphy, evoked potentials, auto-immunity and subpial transection are summarized.
Nieuwenhuis
Lotte
L
The Department of Neurology, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands. NieuwenhuisL@kempenhaeghe.nl
Nicolai
Joost
J
D000927:Anticonvulsants / Q000009:adverse effects; D015551:Autoimmunity; D001519:Behavior / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology*; D003943:Diagnostic Techniques, Neurological; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012890:Sleep / Q000502:physiology
D000927:Anticonvulsants; D005947:Glucose