Early mid-trimester serum relaxin, soluble CD163, and cervical length in women at high risk for preterm delivery.
OBJECTIVE
The purpose of this study was to evaluate the relationship between serum concentrations of relaxin and soluble CD163 with cervical length and preterm delivery in women with previous spontaneous preterm delivery.


METHODS
Sixty-one of 69 pregnant women with a previous spontaneous preterm had serum relaxin and soluble CD163 measured at week 16 (range, 12-25 weeks). End points were cervical length and gestational age at delivery.


RESULTS
Of the 61 women, 26% had >1 previous spontaneous preterm delivery; 84% were black; 87% were unmarried; 13% were smokers, and 39% were delivered before 37 weeks of gestation. Neither relaxin (median, 368 ng/L; range, 83-1493 ng/L) nor soluble CD163 (2.4 mg/L; range, 0.86-6.85 mg/L) correlated with cervical length or gestational age at delivery. Black women had higher relaxin levels (436 vs 205 ng/L; P = .002), but soluble CD163 levels were similar among racial groups.


CONCLUSIONS
Relaxin and soluble CD163 measured at 16 weeks of gestation are not clinically useful predictors of short cervical length or preterm delivery in women with a previous spontaneous preterm delivery.
Vogel
Ida
I
North Atlantic Neuro-epidemiology Alliances (NANEA), Department of Epidemiology, Institute for Public Health, University of Aarhus, Denmark. iv@soci.au.dk
Goepfert
Alice R
AR
Møller
Holger J
HJ
Cliver
Suzanne
S
Thorsen
Poul
P
Andrews
William W
WW
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D015992:Body Mass Index; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D047928:Premature Birth / Q000503:physiopathology*; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000097:blood*; D012065:Relaxin / Q000097:blood*; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; D012065:Relaxin