The interplay between structure-based design and combinatorial chemistry.
The two most lauded drug design approaches from the past century--structure-based design and combinatorial chemistry--are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.
Rupasinghe
Chamila N
CN
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Spaller
Mark R
MR
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015394:Molecular Structure