title: Improvement of Bacillus thuringiensis delta-endotoxins synthesis yields through acquisition of erythromycin resistance.
abstract: The acquisition of the erythromycin resistance by Bacillus thuringiensis kurstaki improved yields of delta-endotoxins in sporulating cells ranging from 134 to 215%. Resistance to erythromycin decreased the final spore count by at least 50%. Consequently, erythromycin resistance is an efficient tool for the improvement of bioinsecticides yields with a high ratio of delta-endotoxins to spores.
authors.affiliation: Laboratory of Biopesticides, Centre of Biotechnology of Sfax, Tunisia P.O. Box K, 3038, Sfax, Tunisia.
authors.forename: Slim
authors.initials: S
authors.lastname: Tounsi
authors.forename: Nabil
authors.initials: N
authors.lastname: Zouari
authors.forename: Dhouha
authors.initials: D
authors.lastname: Ghribi
authors.forename: Anis
authors.initials: A
authors.lastname: J'mal
authors.forename: Samir
authors.initials: S
authors.lastname: Jaoua
mesh_terms: D001413:Bacillus thuringiensis / Q000502:physiology*; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics*; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000502:physiology*; D004731:Endotoxins / Q000096:biosynthesis* / Q000235:genetics*; D004917:Erythromycin / Q000008:administration & dosage*; D024861:Genetic Enhancement / Q000379:methods; D006460:Hemolysin Proteins / Q000096:biosynthesis* / Q000235:genetics*; D015202:Protein Engineering / Q000379:methods*; D011498:Protein Precursors / Q000096:biosynthesis*
chemical_list: D000083722:Bacillus thuringiensis Toxins; C029103:Bacillus thuringiensis protoxin; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004731:Endotoxins; D006460:Hemolysin Proteins; D011498:Protein Precursors; C030956:insecticidal crystal protein, Bacillus Thuringiensis; D004917:Erythromycin