The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.
We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.
Chlosta
Sabine
S
Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Fishman
Douglas S
DS
Harrington
Lynne
L
Johnson
Erin E
EE
Knutson
Mitchell D
MD
Wessling-Resnick
Marianne
M
Cherayil
Bobby J
BJ
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D027682:Cation Transport Proteins / Q000502:physiology*; D002460:Cell Line; D064451:Hepcidins; D007501:Iron / Q000378:metabolism; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D019779:Salmonella enterica / Q000254:growth & development*; D000098742:Ferroportin
D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C579599:Hamp protein, mouse; D064451:Hepcidins; D000098742:Ferroportin; D007501:Iron