title: LONI visualization environment.
abstract: Over the past decade, the use of informatics to solve complex neuroscientific problems has increased dramatically. Many of these research endeavors involve examining large amounts of imaging, behavioral, genetic, neurobiological, and neuropsychiatric data. Superimposing, processing, visualizing, or interpreting such a complex cohort of datasets frequently becomes a challenge. We developed a new software environment that allows investigators to integrate multimodal imaging data, hierarchical brain ontology systems, on-line genetic and phylogenic databases, and 3D virtual data reconstruction models. The Laboratory of Neuro Imaging visualization environment (LONI Viz) consists of the following components: a sectional viewer for imaging data, an interactive 3D display for surface and volume rendering of imaging data, a brain ontology viewer, and an external database query system. The synchronization of all components according to stereotaxic coordinates, region name, hierarchical ontology, and genetic labels is achieved via a comprehensive BrainMapper functionality, which directly maps between position, structure name, database, and functional connectivity information. This environment is freely available, portable, and extensible, and may prove very useful for neurobiologists, neurogenetisists, brain mappers, and for other clinical, pedagogical, and research endeavors.
authors.affiliation: Center for Computational Biology and Laboratory of Neuro Imaging, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA. ivo.dinov@loni.ucla.edu
authors.forename: Ivo D
authors.initials: ID
authors.lastname: Dinov
authors.forename: Daniel
authors.initials: D
authors.lastname: Valentino
authors.forename: Bae Cheol
authors.initials: BC
authors.lastname: Shin
authors.forename: Fotios
authors.initials: F
authors.lastname: Konstantinidis
authors.forename: Guogang
authors.initials: G
authors.lastname: Hu
authors.forename: Allan
authors.initials: A
authors.lastname: MacKenzie-Graham
authors.forename: Erh-Fang
authors.initials: EF
authors.lastname: Lee
authors.forename: David
authors.initials: D
authors.lastname: Shattuck
authors.forename: Jeff
authors.initials: J
authors.lastname: Ma
authors.forename: Craig
authors.initials: C
authors.lastname: Schwartz
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
mesh_terms: D001931:Brain Mapping; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D003952:Diagnostic Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008122:Local Area Networks; D009446:Neurobiology / Q000295:instrumentation*; D012984:Software; D014584:User-Computer Interface