RGS4 genotype is not associated with antipsychotic medication response in schizophrenia.
The aims of the present study were to compare the allele frequencies of a common single nucleotide polymorphism located upstream of the regulator of G-protein signaling 4 (RGS4) gene (T > G, Rs 951436) in 219 Finnish patients with schizophrenia and in 389 control subjects, to analyze corresponding frequencies between two different subtypes of 93 schizophrenia patients according to their medication response, and to study the effect of this SNP on age at onset in schizophrenia. The RGS4 (T > G, Rs 951436) genotype was not associated with incidence or age at onset in schizophrenia. Neither was the RGS4 genotype associated with medication response with two different subpopulations with schizophrenia.
Kampman
O
O
Medical School, University of Tampere, Tampere, Finland. olli.kampman@uta.fi
Illi
A
A
Hänninen
K
K
Katila
H
H
Anttila
S
S
Rontu
R
R
Mattila
K M
KM
Leinonen
E
E
Lehtimäki
T
T
D000328:Adult; D017668:Age of Onset; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049668:History, 15th Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*
D014150:Antipsychotic Agents; D020710:RGS Proteins; C098799:RGS4 protein