The susceptibility of anaerobic bacteria isolated from periodontal diseases to photodynamic inactivation with Fotolon (chlorin e6).
Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report the activity of the Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against anaerobic bacteria isolated from periodontal diseases. Over 99.9% reduction in colony forming units in 20 Gram-positive and 30 Gram-negative clinical anaerobic strains was obtained.
Drulis-Kawa
Zuzanna
Z
Institute of Genetics and Microbiology, University of Wrocław, Poland. kawa@microb.uni.wroc.pl
Bednarkiewicz
Artur
A
Bugla-Płoskonska
Gabriela
G
Strek
Wiesław
W
Doroszkiewicz
Włodzimierz
W
D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D002735:Chlorophyllides; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D066298:In Vitro Techniques; D010510:Periodontal Diseases / Q000188:drug therapy / Q000382:microbiology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*
D002735:Chlorophyllides; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin