title: Analgesic and hepatotoxic effects of Ononis spinosa L.
abstract: The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl(4))-induced acute liver toxicity was also studied. The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05). Thus, the results reveal that the extract of OS had no hepatoprotective effect on CCl(4)-induced acute liver toxicity.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey.
authors.forename: Betül Sever
authors.initials: BS
authors.lastname: Yilmaz
authors.forename: Hanefi
authors.initials: H
authors.lastname: Ozbek
authors.forename: Gülçin Saltan
authors.initials: GS
authors.lastname: Citoğlu
authors.forename: Serdar
authors.initials: S
authors.lastname: Uğraş
authors.forename: Irfan
authors.initials: I
authors.lastname: Bayram
authors.forename: Ender
authors.initials: E
authors.lastname: Erdoğan
mesh_terms: D000410:Alanine Transaminase / Q000187:drug effects; D000700:Analgesics / Q000032:analysis*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects; D001663:Bilirubin / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009619:Nociceptors / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin