Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene.
In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.
Birosová
Lucia
L
Department of Biochemistry and Microbiology, Slovak University of Technology, Bratislava, Slovakia. lucia.birosova@stuba.sk
Mikulásová
Mária
M
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005449:Fluorenes / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000187:drug effects; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics*
D000890:Anti-Infective Agents; D005449:Fluorenes; C019499:2-nitrofluorene; D002939:Ciprofloxacin