title: [Ionic calcium and magnesium from pharmaceutical product BEROCCA effects on neuromuscular excitability].
abstract: The important physiological role of calcium and magnesium ions is all over recognised, about a lot of enzymatic reactions. Magnesium deficit produce neuromuscular hyper-reactivity, psychic reactions, functional hypoparathyroidism, increase of K+ channels membranes permeability, while hypermagnesemia decrease Ach release from neuromuscular synapsis, with post-synaptic excitability decreasing. Using BEROCCA (Hoffman la Roche) 1 cp/day, 30 days at the teenagers with behaviour troubles and at a goup of pregnant women (trimester I-III) with paresthesia, irritability, sleeplessness, we observed an improve of clinical signs, increasing plasma Ca2+ and Mg2+. EEG and EMG prove the beneficial effects of pharmaceutical product BEROCCA.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Disciplina de Explorări Funcţionale.
authors.forename: Ana
authors.initials: A
authors.lastname: Stratone
authors.forename: Carmen
authors.initials: C
authors.lastname: Stratone
authors.forename: Roxana
authors.initials: R
authors.lastname: Chiruţă
authors.forename: D
authors.initials: D
authors.lastname: Zaharia
authors.forename: Lidia
authors.initials: L
authors.lastname: Căruntu
authors.forename: Mariana
authors.initials: M
authors.lastname: Diaconu
authors.forename: Oana
authors.initials: O
authors.lastname: Stefancu
authors.forename: Fl
authors.initials: F
authors.lastname: Topoliceanu
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D002118:Calcium / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D015507:Drugs, Investigational / Q000494:pharmacology* / Q000627:therapeutic use; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008274:Magnesium / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009468:Neuromuscular Diseases / Q000188:drug therapy; D009469:Neuromuscular Junction / Q000187:drug effects*; D011247:Pregnancy; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D015507:Drugs, Investigational; D009466:Neuromuscular Blocking Agents; D014803:Vitamin B Complex; D008274:Magnesium; D001205:Ascorbic Acid; D002118:Calcium