The integration of cell and chemical biology in protein folding.
Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.
Kelly
Jeffery W
JW
Department of Chemistry and The Skaggs Institute for Chemical Biology, La Jolla, California 92130, USA. jkelly@scripps.edu
Balch
William E
WE
D001669:Biochemical Phenomena; D001671:Biochemistry; D003585:Cell Biology; D003593:Cytoplasm / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000737:chemistry / Q000378:metabolism*; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
D011506:Proteins