Some nuts are tougher to crack than others.
In this issue of Immunity, Oestreich et al. (2006) show that, during V(D)J recombination, RSSs may have distinct accessibility requirements. Some rely on an enhancer-intrinsic, general chromatin opening function, whereas others require enhancer-promoter interactions that direct local chromatin remodeling.
Krangel
Michael S
MS
Department of Immunology, P.O. Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA.
Carabana
Juan
J
Abarrategui
Iratxe
I
D000818:Animals; D000916:Antibody Diversity / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D019672:Genes, T-Cell Receptor / Q000235:genetics*; D006801:Humans; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics