Catalytic enantioselective O-H insertion reactions.
The first effective method for catalytic enantioselective insertions into O-H bonds has been developed. Specifically, a copper/bisazaferrocene catalyst couples alcohols such as 2-trimethylsilylethanol with alpha-aryl-alpha-diazo esters in high yield and good ee.
Maier
Thomas C
TC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fu
Gregory C
GC
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000438:Alcohols; D004952:Esters; D004987:Ethers