Leishmanicidal activity of Pycnoporus sanguineus.
In the search for antiparasite compounds from the Colombian flora, an active compound against Leishmania (Viannia) panamensis amastigotes was isolated from the fungi Pycnoporus sanguineus. The structural elucid-ation was achieved with spectroscopic methods ((1)H and (13)C NMR and MS). This compound was identified as ergosterol 5,8-endoperoxide.
Correa
Edwin
E
Grupo de Química Orgánica de Productos Naturales-SIU, Universidad de Antioquia, P.O. Box 1226, Medellín-Colombia.
Cardona
Diana
D
Quiñones
Winston
W
Torres
Fernando
F
Franco
Ana E
AE
Vélez
Ivan D
ID
Robledo
Sara
S
Echeverri
Fernando
F
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D018334:Leishmania guyanensis; D011124:Polyporaceae / Q000737:chemistry* / Q000254:growth & development
D000981:Antiprotozoal Agents; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol