title: Exaggerated blood pressure response to exercise is associated with carotid atherosclerosis in apparently healthy men.
abstract: OBJECTIVE
  Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sectional study of 9073 healthy men (aged 47.8 +/- 8.8 years).
  
  
  METHODS
  Exaggerated SBP response was defined as an SBP of 210 mmHg or greater during a maximal treadmill test. Carotid atherosclerosis was defined as stenosis greater than 25% or intima-media thickness greater than 1.2 mm using B-mode ultrasonography.
  
  
  RESULTS
  An exaggerated SBP response was present in 375 men (4.1%). The proportion of individuals with carotid atherosclerosis in the group with an exaggerated SBP response to exercise was higher than in the group with a normal SBP response (14.4 versus 5.3%, P < 0.001). In a multivariable logistic regression model, individuals with an exaggerated SBP (>or= 210 mmHg) response to exercise had a 2.02 times [95% confidence interval (CI) 1.33-3.05] increased risk of carotid atherosclerosis compared with individuals with an SBP response of less than 210 mmHg. The highest quartile (> 61 mmHg) group of relative exercise-induced increases in SBP showed a 1.57 (95% CI 1.18-2.08) greater risk of carotid atherosclerosis compared with individuals in the lowest quartile (< 38 mmHg) in the adjusted model.
  
  
  CONCLUSIONS
  These results suggest that an exaggerated SBP response to exercise is strongly associated with carotid atherosclerosis, independent of established risk factors in healthy men. It may be an important factor in evaluating hypertension related to target-organ damage.
authors.affiliation: Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, Illinois, USA.
authors.forename: Sae Young
authors.initials: SY
authors.lastname: Jae
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Heffernan
authors.forename: Mira
authors.initials: M
authors.lastname: Kang
authors.forename: Moon-Kyu
authors.initials: MK
authors.lastname: Lee
authors.forename: Yoon Ho
authors.initials: YH
authors.lastname: Choi
authors.forename: Kyung Pyo
authors.initials: KP
authors.lastname: Hong
authors.forename: Eui Soo
authors.initials: ES
authors.lastname: Ahn
authors.forename: Won Hah
authors.initials: WH
authors.lastname: Park
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000150:complications* / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology*; D002340:Carotid Artery Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014463:Ultrasonography