title: Gender difference in the level of high-density lipoprotein cholesterol in elderly Japanese patients with coronary artery disease.
abstract: OBJECTIVE
  High-density lipoprotein cholesterol (HDLC) levels are known to be reduced in the metabolic syndrome, but the HDLC profile of elderly patients with coronary artery disease (CAD) has not been well characterized. This study investigated the gender difference of HDLC levels in elderly Japanese patients with CAD.
  
  
  METHODS
  Serum lipid data were analyzed retrospectively to assess sex-related differences of the lipid profile, and to evaluate the effects of pharmacotherapy or physical exercise on hyperlipidemia.
  
  
  METHODS
  A total of 163 elderly (> or = 65 years) outpatients with CAD (128 men aged 70.6+/-5.2 years and 35 women aged 74.1+/-6.0 years [mean+/-SD]) were investigated.
  
  
  RESULTS
  The mean total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) levels were similar in men and women, while the mean HDLC level was significantly higher in women than men (58.3+/-18.1 vs. 50.3+/-13.5 mg/dL; p=0.0064). The HDLC level was not significantly influenced by oral lipid-lowering therapy or regular exercise in either sex. However, women without lipid-lowering therapy had significantly higher HDLC levels than men with (p=0.0312) or without (p=0.0338) lipid-lowering therapy, while women performing regular exercise had significantly higher HDLC levels than men with (p=0.0047) or without (p<0.001) regular exercise.
  
  
  CONCLUSIONS
  Elderly women with CAD have higher HDLC levels relative to their postmenopausal state than those of men with CAD. Low HDLC levels, unlike in men, may not be a major risk factor for CAD in elderly women.
authors.affiliation: Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine.
authors.forename: Haruki
authors.initials: H
authors.lastname: Musha
authors.forename: Akio
authors.initials: A
authors.lastname: Hayashi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kida
authors.forename: Eiji
authors.initials: E
authors.lastname: Takahashi
authors.forename: Kae
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Koji
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Akashi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kunishima
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D017698:Postmenopause / Q000097:blood; D012189:Retrospective Studies; D012737:Sex Factors; D014280:Triglycerides / Q000032:analysis
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D014280:Triglycerides