Total synthesis of (+/-)-galanthamine.
[reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation, respectively.
Hu
Xiang-Dong
XD
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PRC.
Tu
Yong Qiang
YQ
Zhang
En
E
Gao
Shuanhu
S
Wang
Shaohua
S
Wang
Aixia
A
Fan
Chun-An
CA
Wang
Min
M
D002384:Catalysis; D003500:Cyclization; D005702:Galantamine / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D005702:Galantamine