title: Benefit of amoxicillin in differentiating between TB suspects whose initial AFB sputum smears are negative.
abstract: METHODS
  Out-patient dispensary in Conakry, Guinea, West Africa.
  
  
  OBJECTIVE
  To differentiate between pulmonary tuberculosis (PTB) and non-PTB diseases among 204 acid-fast bacilli (AFB) smear-negative adult TB suspects.
  
  
  METHODS
  We derived scores from clinical, serological and radiological findings among PTB suspects aged > or = 15 years who, after having had three AFB-negative smears, were treated for 10 days with amoxicillin (AMX, 1.5 g/day).
  
  
  RESULTS
  At the selected cut-off score from model 1 (clinical), sensitivity for PTB was 95%, specificity 40%, negative predictive value (NPV) 84%, and positive predictive value (PPV) 69%. Comparable values from model 2 (clinical + serological + radiological) were: sensitivity 99%, specificity 45%, NPV 97%, and PPV 71%. Results from AMX were better: sensitivity 92%, specificity 93%, NPV 94%, and PPV 91%. Of the 117 suspects who failed to respond clinically and radiographically to AMX and remained AFB smear-negative, 110 (94%) had PTB, confirmed either by positive culture (73 patients) or response to anti-tuberculosis treatment (37 patients).
  
  
  CONCLUSIONS
  The clinical and radiographic response to AMX is better than derived scores at differentiating between PTB and non-PTB in TB suspects presenting to a dispensary in Guinea, a low HIV-seroprevalence country.
authors.affiliation: INSERM, U707Université Pierre et Marie Curie, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Kudjawu
authors.forename: V
authors.initials: V
authors.lastname: Massari
authors.forename: O
authors.initials: O
authors.lastname: Sow
authors.forename: B
authors.initials: B
authors.lastname: Bah
authors.forename: B
authors.initials: B
authors.lastname: Larouzé
authors.forename: J F
authors.initials: JF
authors.lastname: Murray
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D016701:Guinea / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin