title: Effects of oral glutamine supplementation on children with solid tumors receiving chemotherapy.
abstract: In recent years, there have been reports that glutamine support improves immune functions in adult patients with malignancy, but there is a lack of data in children. Oral glutamine support of 4 g/m2/day was given to 21 children with various solid tumors, aged 1-17 years (9.86 +/- 5.38) for all 5 days of a chemotherapy course. The same parameters in another course of the same protocol without glutamine supplementation were considered as controls. There were significant improvements of some nutritional and immunological parameters in the glutamine-supplemented course. Also glutamine seemed to reduce antibiotic necessity. Oral glutamine supplementation could be considered in children with solid tumors receiving chemotherapy.
authors.affiliation: Department of Pediatric Metabolism and Nutrition, Gazi University Faculty of Medicine, Ankara, Turkey. arzu@okur.net
authors.forename: Arzu
authors.initials: A
authors.lastname: Okur
authors.forename: Fatih Süheyl
authors.initials: FS
authors.lastname: Ezgü
authors.forename: Leyla
authors.initials: L
authors.lastname: Tümer
authors.forename: Gülden
authors.initials: G
authors.lastname: Cinasal
authors.forename: Aynur
authors.initials: A
authors.lastname: Oguz
authors.forename: Alev
authors.initials: A
authors.lastname: Hasanoglu
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karadeniz
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D005260:Female; D005973:Glutamine / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007155:Immunologic Factors; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D009752:Nutritional Status / Q000187:drug effects; D010288:Parenteral Nutrition; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D005973:Glutamine