Correction of copper deficiency improves erythropoietin unresponsiveness in hemodialysis patients with anemia.
We have encountered five hemodialysis patients who had received enteral nutrition and recovered from erythropoietin-resistant anemia with neutropenia after the correction of copper deficiency. We reduced the required doses of recombinant human erythropoietin (rHuEPO) to maintain the target hematocrit levels and three patients were finally weaned from the rHuEPO therapy. Thus, copper deficiency is involved in erythropoietin-resistant anemia in hemodialysis patients.
Higuchi
Terumi
T
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Oyaguchi-Kamimachi, Tokyo.
Matsukawa
Yoshihiro
Y
Okada
Kazuyoshi
K
Oikawa
Osamu
O
Yamazaki
Toshio
T
Ohnishi
Yoshihiko
Y
Fujita
Takayuki
T
Fukuda
Noboru
N
Soma
Masayoshi
M
Matsumoto
Koichi
K
D000740:Anemia / Q000188:drug therapy*; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood / Q000172:deficiency*; D019327:Copper Sulfate / Q000008:administration & dosage / Q000627:therapeutic use; D003677:Deficiency Diseases / Q000209:etiology / Q000628:therapy; D004750:Enteral Nutrition / Q000009:adverse effects*; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D011994:Recombinant Proteins; D006435:Renal Dialysis; D017211:Treatment Failure
D011994:Recombinant Proteins; D004921:Erythropoietin; D003300:Copper; D002570:Ceruloplasmin; D019327:Copper Sulfate