title: Docetaxel administered during pregnancy for inflammatory breast carcinoma.
abstract: We report the case of a 35-year-old pregnant woman with inflammatory breast carcinoma initially treated with 5-fluorouracil/doxorubicin/cyclophosphamide beginning her 13th week of pregnancy. There was no noticeable shrinkage of the axillary or breast tumors after 4 cycles, at which point the patient accepted a treatment change to docetaxel. Four cycles of docetaxel at 100 mg/m2 every 21 days were delivered from the 25th week of pregnancy with good tolerance. She exhibited a clinical complete response, determined by clinical examination and imaging tests. Obstetric monitoring with fetal ultrasound showed normal fetal development throughout chemotherapy. After delivery of a healthy child, she underwent surgery, which showed tumor downstaging to pT0 N2, followed by radiation therapy and hormone therapy. This report suggests the safety of docetaxel after the first trimester of pregnancy.
authors.affiliation: Department of Medical Oncology, University of Navarra, Pamplona, Spain. ynieto@unav.es
authors.forename: Yago
authors.initials: Y
authors.lastname: Nieto
authors.forename: Marta
authors.initials: M
authors.lastname: Santisteban
authors.forename: José M
authors.initials: JM
authors.lastname: Aramendía
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández-Hidalgo
authors.forename: Manuel
authors.initials: M
authors.lastname: García-Manero
authors.forename: Guillermo
authors.initials: G
authors.lastname: López
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D047109:Fetal Development; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007249:Inflammation; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil