title: [Olfactory groove meningioma: correlation between clinicoradiological features and proliferative index (Mib-1)].
abstract: OBJECTIVE
  The aim of this study is to correlationate demographic, radiologic features and proliferative index defined by immunohistochemical expression of Mib-1 in olfactory groove meningiomas, and to observe possible predictive factors of recurrence of this tumor.
  
  
  METHODS
  There were analysed demographic, clinical and radiological features of 15 patients with olfactory groove meningioma. Fifteen paraffin-embebed tumors were studied by immunohistochemical methods for the expression of proliferative index by the Mib-1.
  
  
  RESULTS
  There was a statistically positive correlation between tumoral and edema volumes. There was no correlation between Mib-1, tumoral volume, tumoral edema and frontal skull base abnormalities. Two cases with tumor recurrence had proliferative indices higher than the mean index.
  
  
  CONCLUSIONS
  Larger tumors were more susceptible to develop peritumoral edema. The proliferative índex has no positive correlation with tumoral volume, edema volumes and skull base invasion, but probably it is associated with tumoral recurrence.
authors.affiliation: Hospital Edmundo Vasconcelos, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil. mapnpaiva@ig.com.br
authors.forename: Manoel Antonio de
authors.initials: MA
authors.lastname: Paiva Neto
authors.forename: Oswaldo Inácio de
authors.initials: OI
authors.lastname: Tella
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Herculano
authors.forename: João Norberto
authors.initials: JN
authors.lastname: Stávale
authors.forename: Antonio Pádua Furquim
authors.initials: AP
authors.lastname: Bonatteli
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins