Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility.
The purpose of this study was to analyze the relationship of male age and DNA integrity in men presenting for investigation of infertility. We found that men 45 years and older had significantly greater DNA fragmentation than younger men.
Moskovtsev
Sergey I
SI
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
Willis
Jennifer
J
Mullen
J Brendan M
JB
D000328:Adult; D000375:Aging; D053938:DNA Fragmentation; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013094:Spermatozoa