title: Four cases of Graves' disease which developed after painful Hashimoto's thyroiditis.
abstract: We report four cases of Graves' disease that developed after painful Hashimoto's thyroiditis. All were middle-aged women, who had high titers of anti-thyroid antibodies and thyrotoxicosis at the onset of painful Hashimoto's thyroiditis. After 2 to 7 years, they developed Graves' disease with positive antibody against the thyrotropin receptor. Their clinical courses of Graves' disease went favorably due to the treatment with antithyroid drug or radioactive iodine therapy. Painful Hashimoto's thyroiditis is an atypical variant of Hashimoto's thyroiditis and is one form of destructive thyroiditis. Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease.
authors.affiliation: Department of Internal Medicine, Kuma Hospital, Kobe.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohye
authors.forename: Eijun
authors.initials: E
authors.lastname: Nishihara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sasaki
authors.forename: Sumihisa
authors.initials: S
authors.lastname: Kubota
authors.forename: Shuji
authors.initials: S
authors.lastname: Fukata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Amino
authors.forename: Kanji
authors.initials: K
authors.lastname: Kuma
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D013956:Antithyroid Agents / Q000008:administration & dosage; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006111:Graves Disease / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008713:Methimazole / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D013960:Thyroid Function Tests
chemical_list: D013956:Antithyroid Agents; D005938:Glucocorticoids; D008713:Methimazole; D002097:C-Reactive Protein; D011239:Prednisolone