Addressing the challenges of cellular delivery and bioavailability of peptide nucleic acids (PNA).
Recent results on the cellular delivery of antisense peptide nucleic acids (PNA) via peptide conjugation is briefly discussed, in particular in the context of endosomal entrapment and escape.
Nielsen
Peter E
PE
Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Blegdamsvej 3c, 2200 Copenhagen N, Denmark. pen@imbg.ku.dk
D000818:Animals; D001682:Biological Availability; D055592:Biophysical Phenomena; D001703:Biophysics; D011992:Endosomes / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000493:pharmacokinetics; D020135:Peptide Nucleic Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*
D020319:Oligodeoxyribonucleotides, Antisense; D020135:Peptide Nucleic Acids