In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T.
This work presents a method that allows for the assessment of 3D murine myocardial motion in vivo at microscopic resolution. Phase-contrast (PC) magnetic resonance imaging (MRI) at 17.6 T was applied to map myocardial motion in healthy mice along three gradient directions. High-resolution velocity maps were acquired at three different levels in the murine myocardium with an in-plane resolution of 98 mum, a slice thickness of 0.6 mm, and a temporal resolution of 6 ms. The applied PC-MRI method was validated with phantom experiments that confirmed the correctness of the method with deviations of <1.7%. Myocardial in-plane velocities between 0.5 cm/s and 2.2 cm/s were determined for the healthy murine myocardium. Through-plane velocities of 0.1-0.83 cm/s were measured. Velocity data was also used to calculate the myocardial twist angle during systole at different slices in the short-axis view.
Herold
Volker
V
Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany. vrherold@physik.uni-wuerzburg.de
Mörchel
Philipp
P
Faber
Cornelius
C
Rommel
Eberhard
E
Haase
Axel
A
Jakob
Peter M
PM
D000465:Algorithms; D000818:Animals; D005240:Feasibility Studies; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D009068:Movement / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D019047:Phantoms, Imaging; D012031:Refractometry / Q000379:methods; D016277:Ventricular Function, Left / Q000502:physiology*