title: Intravascular lymphoma and thyroid gland.
abstract: Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of neoplastic cells in the small blood vessels that frequently goes undiagnosed until the time of autopsy. The neoplastic cells are usually of B-cell origin. The clinical course was examined to determine factors that would facilitate antemortem diagnosis. IVL is observed with clinical, histopathological and immunohystochemical methods. This is a unique case because the thyroid gland is a rare place for IVL. Accent is given on immunohystochemical methods and tissue biopsy in the differential diagnosis of IVL when nervous system and thyroid gland dysfunction occur This report indicates that micro-ecosystem of multinodular goitrous might influence the expression of chemokines and/or adhesion moleculs on endothelial and lymphoma cells, leading to heavy infiltration of thyroid gland. Concurrently, that may guide the physician to tissue biopsy facilitating antemortem diagnosis and institution of appropriate therapy.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Internal Medicine, University Hospital "Sestre milosrdnice", Zagreb, Croatia. darkodominik@yahoo.com
authors.forename: Darko
authors.initials: D
authors.lastname: Katalinić
authors.forename: Toni
authors.initials: T
authors.lastname: Valković
authors.forename: Ksenija
authors.initials: K
authors.lastname: Lucin
authors.forename: Josip
authors.initials: J
authors.lastname: Rudez
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D013961:Thyroid Gland / Q000473:pathology*