title: Ceftriaxone induced hemolysis complicated by acute renal failure.
abstract: Over the last decade, second and third generation cephalosporins have been the most common drugs causing hemolytic anemia (HA). Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, cardio-respiratory arrest and shock. Acute renal failure (ARF) has been reported in 41% of such cases with a high fatality rate. We report a pediatric patient with ARF complicating ceftriaxone-induced HA who survived. Ceftriaxone is a commonly used drug, and early recognition of HA and institution of supportive care, including dialysis is likely to improve the outcome.
authors.affiliation: Division of Nephrology and Hypertension, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA. gkapur@dmc.org
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kapur
authors.forename: Rudolph P
authors.initials: RP
authors.lastname: Valentini
authors.forename: Tej K
authors.initials: TK
authors.lastname: Mattoo
authors.forename: Indira
authors.initials: I
authors.lastname: Warrier
authors.forename: Abubakr A
authors.initials: AA
authors.lastname: Imam
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002443:Ceftriaxone / Q000009:adverse effects*; D002648:Child; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone