[Predictive biochemical indicators of a postlaryngectomy pharyngocutaneous fistula: a clinical study].
The aim of this clinical study was to determinate biochemical predictor indicators of postlaryngectomy pharyngocutaneous fistula.


METHODS
We have studied 100 patients with T2- 4 a laryngeal and piryform sinus carcinoma who underwent a laryngectomy. All patients were ASA 2-3. We studied serum albumin, protein serum level, cholesterol and lymphocites in each patient. These variables underwent statistical analysis (p < 0.05).


RESULTS
19% of the patients developed a postlaryngectomy pharyngocutaneous fistula, with a long-stay of 25 days vs. 10 days of stay in patients without postlaryngectomy pharyngocutaneous fistula. 7 postlaryngectomy pharyngocutaneous fistula needed surgical repair. Low serum albumin (< 3.5 g/dL) and a low level of serum proteins (< 6.5 g/dL) were predictive indicators of postlaryngectomy pharyngocutaneous fistula (p < 0.05).


CONCLUSIONS
Our results suggest that a low-level of serum proteins and albumin are predictive clinical parameters of postlaryngeal pharyngocutaneous fistula.
Martín Villares
C
C
Servicio ORL, Hospital del Bierzo, Ponferrada, León. cmvillares@hotmail.com
Pomar
P
P
Iglesias
M C
MC
San Román
J
J
Fernández Pello
M
M
Aldama
P
P
González Gimeno
M J
MJ
Tapia
M
M
D015415:Biomarkers / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D017577:Cutaneous Fistula / Q000097:blood* / Q000209:etiology*; D005402:Fistula / Q000097:blood* / Q000209:etiology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery; D007825:Laryngectomy / Q000009:adverse effects*; D010608:Pharyngeal Diseases / Q000097:blood* / Q000209:etiology*; D011446:Prospective Studies
D015415:Biomarkers