Massive cutaneous follicular lymphoid hyperplasia in a patient with the Sjögren syndrome: 7-year follow-up and immunohistochemical study.
The Sjögren syndrome often gives rise to complications such as pseudolymphomas and/or mucosa-/skin-associated lymphocytic tumors (MALT/SALT lymphomas). This paper presents a 74-year-old female patient with the Sjögren syndrome complicated by cutaneous plaques/tumors as cutaneous lymphoid hyperplasia over a 7-year follow-up study period. Immunohistochemical examination disclosed B-cell rich lymphoid follicle formation in the skin with the presence of T and B cells and a varied assortment of features to include abundant plasma cell infiltration. Based on the clinical course and histopathological findings, patient condition was considered benign and arises from reaction toward certain unknown microbes.
Horiuchi
Yasuhiro
Y
Department of Dermatology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501 Nagasaki, Japan. ngu-yashoriu@r7.dion.ne.jp
Hakugawa
Junichi
J
Shimizu
Kazuhiro
K
Katayama
Ichiro
I
Hayashi
Tomayoshi
T
Kikuchi
Masahiro
M
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019310:Pseudolymphoma / Q000175:diagnosis* / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications*; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology