Antiviral drug discovery targeting to viral proteases.
Proteases fulfill multiple roles in health and disease, and considerable interest has been expressed in the design and development of synthetic inhibitors of disease-related proteases. Virus-encoded proteases have been shown to be involved in the replication of many viruses. The success of anti-HIV-1 therapy using specific and potent protease inhibitors suggests that viral proteases can be the valid molecular targets for the development of antiviral drugs against other viruses. Intensive genetic and biochemical studies have been conducted on viral proteases and new insights and results are rapidly emerging. This work reviews features of viral proteases with respective to the development of effective antiviral therapy.
Hsu
John T A
JT
Division of Biotechnology and Pharmaceutical Research, National Health Resarch Institutes, Zhunan, Taiwan.
Wang
Hsiang-Ching
HC
Chen
Guang-Wu
GW
Shih
Shin-Ru
SR
D000998:Antiviral Agents / Q000494:pharmacology*; D017934:Coronavirus / Q000187:drug effects / Q000201:enzymology; D015195:Drug Design; D024882:Drug Resistance, Viral; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects / Q000201:enzymology; D006564:Herpesviridae / Q000187:drug effects / Q000201:enzymology; D010849:Picornaviridae / Q000187:drug effects / Q000201:enzymology; D011480:Protease Inhibitors / Q000494:pharmacology*
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D011480:Protease Inhibitors