title: Cohort analysis of two multidisciplined adherence intervention programmes for patients on antiretroviral therapy.
abstract: The aim was to analyse data from two randomized controlled trials (RCTs) to determine if an adherence intervention programme for antiretroviral therapy (ART) resulted in a reduction in viral load. A cohort analysis of pre- and post-intervention viral loads and CD4 counts using paired analysis was undertaken on participants who received the intervention programme. Analysis was also undertaken on a control group. The intervention participants had an increase in mean CD4 count (450-478, P = 0.26), and a decline in log viral load (2.48-2.36, P = 0.056). The control group had a decline in mean CD4 counts (596-570, P = 0.53), and an increase in log viral load (2.09-2.11, P = 0.78). The use of an adherence intervention programme is associated with a decrease in mean viral load, which is in contrast to the control group that demonstrated an increase in viral load over time.
authors.affiliation: Department of Public Health, University of Melbourne, Melbourne, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Doxanakis
authors.forename: T
authors.initials: T
authors.lastname: Read
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: A
authors.initials: A
authors.lastname: Mijch
authors.forename: C K
authors.initials: CK
authors.lastname: Fairley
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D015337:Multicenter Studies as Topic; D010349:Patient Compliance / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic; D014739:Victoria; D019562:Viral Load