[Effect of vitamin B12 mixed solution inhalation for acute radiation-induced mucosal injury].
OBJECTIVE
To evaluate the therapeutic effect of inhalation of vitamin B12 mixed solution in treating acute radiation-induced mucosal injury.


METHODS
Totally 122 patients with acute radiation-induced mucosal injury resulting from radiotherapy were divided into two equal groups and received vitamin B12 mixed solution inhalation and gentamycin sulfate mixed solution inhalation, respectively.


RESULTS
The patients receiving inhalation of vitamin B12 mixed solution showed favorable response to the treatment and the mucosal injury was alleviated as manifested by relieved pains, improved appetite and lessened body weight loss, which allowed uninterrupted administration of radiotherapy. In patients treated with inhalation of gentamycin sulfate mixed solution, by contrast, the mucosal injury was serious and in 8 patients radiotherapy had to be suspended for acute radiation-induced mucosal injury.


CONCLUSIONS
Vitamin B12 mixed solution inhalation can be an effective treatment for acute radiation-induced mucosal injury.
Chen
Xiang-long
XL
Center of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xianglongchen@21cn.com
Shi
Yu-sheng
YS
D000280:Administration, Inhalation; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000293:injuries*; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000188:drug therapy*; D014805:Vitamin B 12 / Q000008:administration & dosage*
D014805:Vitamin B 12