Estrogen counteracts ozone-induced oxidative stress and nigral neuronal death.
Oxidative stress is implicated in the premature death of dopamine neurons in substantia nigra in Parkinson's disease. The incidence of Parkinson's disease is higher in men than in women, and estrogen may provide neuroprotection against oxidative damage. We examined the protective effects of estrogen on rat nigral death after chronic ozone inhalation. Ozone inhalation produced impaired nigral cell morphology and loss of dopamine neurons in ovariectomized rats. This was counteracted after 60 days of 17beta-estradiol treatment, when blood levels were highest. These results indicate that ozone exposure may be a useful Parkinson's disease model and neuroprotection afforded by 17beta-estradiol is dependent on the high levels achieved after its prolonged administration.
Angoa-Pérez
Mariana
M
Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico.
Jiang
Hao
H
Rodríguez
Alba I
AI
Lemini
Cristina
C
Levine
Robert A
RA
Rivas-Arancibia
Selva
S
D000818:Animals; D015153:Blotting, Western / Q000379:methods; D002452:Cell Count / Q000379:methods; D016923:Cell Death / Q000187:drug effects; D004347:Drug Interactions; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry / Q000379:methods; D015227:Lipid Peroxidation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D010083:Oxidants, Photochemical / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010126:Ozone / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000166:cytology*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D010083:Oxidants, Photochemical; D004958:Estradiol; D010126:Ozone; D014446:Tyrosine 3-Monooxygenase