Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2.
The controllability of stressors modulates many of the consequences of stressor exposure. Here, we used immunohistochemistry to examine neural progenitor cell proliferation and survival and basic fibroblast growth factor-2 in the hippocampus of male rats after controllable or uncontrollable tailshock. A series of identical tailshocks were delivered to yoked pairs of rats. One rat could terminate shocks to both rats of the pair. Reductions in neural progenitor cells were observed at 1-2 days and at 28 days in rats exposed to uncontrollable shock. Controllable shock produced an increase in fibroblast growth factor-2 in the dentate gyrus and CA1 2 h after stress and in the dentate gyrus 24 h after stress. Thus, stressor controllability modulates stress-induced decreases in neurogenesis and increases in fibroblast growth factor-2.
Bland
Sondra T
ST
Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, 80309-0345, USA. sondra.bland@colorado.edu
Schmid
Megan J
MJ
Greenwood
Benjamin N
BN
Watkins
Linda R
LR
Maier
Steven F
SF
D000818:Animals; D001522:Behavior, Animal; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation; D002470:Cell Survival; D004597:Electroshock / Q000009:adverse effects; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D051381:Rats; D013234:Stem Cells / Q000502:physiology*; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D013623:Tail / Q000294:innervation / Q000528:radiation effects
D005904:Glial Fibrillary Acidic Protein; D016222:Fibroblast Growth Factor 2; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine