title: New concepts in the treatment of brain tumors in very young children.
abstract: The treatment of brain tumors in infants (children <3 years of age) in the last 15-20 years has been a special field of interest for clinical investigation and research, since infants affected by brain tumors are an ideal experimental group of patients. New treatment strategies (conventional, myeloablative and intraventricular chemotherapy) have been tested on these patients in an effort to avoid or delay conventional irradiation. The amazing amount of knowledge that has been acquired from neuropathological and biological studies, as well as from the first generation treatment baby protocols, which were designed between 1985 and 2000, is now leading to a new approach whereby treatment strategies are tailored to the patient's clinicopathological features.
authors.affiliation: Neuro-Oncology Unit, Hemato-Oncology Department, Giannina Gaslini Children's Research Hospital (IGG), Largo G. Gaslini 5, 16148 Genova, Italy. GARREMA@iol.it
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Garre'
authors.forename: Armando
authors.initials: A
authors.lastname: Cama
authors.forename: Claudia
authors.initials: C
authors.lastname: Milanaccio
authors.forename: Lorenza
authors.initials: L
authors.lastname: Gandola
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
authors.forename: Sandro
authors.initials: S
authors.lastname: Dallorso
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy*; D002675:Child, Preschool; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D000970:Antineoplastic Agents