title: Immunosuppressive treatment for mixed connective tissue disease may facilitate the development of adult T cell leukemia/lymphoma in a HTLVI carrier.
abstract: A 66-year-old woman who was positive for human T-lymphotropic virus type I (HTLV-I) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTL-V-I-related inflammatory diseases, however the development of ATLL during the treatment of HTL-V-I-related MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTD-causative anti-HTLV-I immune response and anti-ATLL immune response.
authors.affiliation: Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima, Sakuragaoka.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakamura
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Kukita
authors.forename: Heiichiro
authors.initials: H
authors.lastname: Hamada
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ozaki
authors.forename: Kakushi
authors.initials: K
authors.lastname: Matsushita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Chuwa
authors.initials: C
authors.lastname: Tei
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015139:Blotting, Southern; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000150:complications; D008775:Methylprednisolone / Q000627:therapeutic use; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood; D013937:Thymidine Kinase / Q000097:blood
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D011239:Prednisolone; D013937:Thymidine Kinase; D008775:Methylprednisolone