[Disseminated infections due to Scedosporium apiospermum in a patient with anaplastic large cell lymphoma. A case study].
A 42-year-old man was diagnosed with hepatosplenic T-cell lymphoma in November 2003. Remission was incompletely achieved despite 10 courses of chemotherapy. He developed fever (38.5-39 degrees C), chills, cough and morning expectoration after the 61 courses of chemotherapy. During this period, an ultrasound of the abdomen showed multiple hypodense lesions of the liver. Culture of the sputum yielded Scedosporium apiospermum. Fungal cultures from blood remained negative. The patient was treated with voriconazol. After one month from therapy, an ultrasound examination showed decreasing of hypodense lesions of the liver, and no further lesions appeared. Based on significant improvement of liver lesions with voriconazole therapy, we proposed the diagnostic "probable" disseminated infections due to S.apiospermum.
Dan
Maria
M
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Disciplina de Microbiologie Medicala, Spitalul Clinic de Urgenţe Sf. Spiridon, Iaşi.
Mereuţă
Ana-Irina
AI
Burcoveanu
Cristina
C
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008271:Mycetoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D021681:Scedosporium / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole