title: Fluorophor-labeled spermidine derivatives as fluorescent markers in optical tumor imaging.
abstract: Up-regulation of polyamine transporters on the surface of tumor cells and the internalization of biogenic polyamines by active transport processes may be exploited for the accumulation of spermidine derivatives as reporter molecules. We have synthesized and tested fluorophor-labeled spermidine derivatives for the development of a new class of intraoperative tumor imaging agents. In vitro uptake experiments and initial in vivo imaging studies illustrated that fluorophor tagged spermidine derivatives show tumor accumulation.
authors.affiliation: Department of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Markus.Wolf@dkfz.de
authors.forename: Markus
authors.initials: M
authors.lastname: Wolf
authors.forename: Ulrike
authors.initials: U
authors.lastname: Bauder-Wüst
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Pipkorn
authors.forename: Helmut
authors.initials: H
authors.lastname: Eskerski
authors.forename: Michael
authors.initials: M
authors.lastname: Eisenhut
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000473:pathology*; D013095:Spermidine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D005456:Fluorescent Dyes; D013095:Spermidine