Building bridges to the cortex.
Innervation of the neocortex by the thalamus is dependent on the precise coordination of spatial and temporal guidance cues. In this issue of Cell, work by López-Bendito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are essential for axonal navigation between the thalamus and the neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling.
Hanashima
Carina
C
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA.
Molnár
Zoltán
Z
Fishell
Gord
G
D000818:Animals; D001369:Axons / Q000378:metabolism*; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D020890:Neuregulin-1 / Q000378:metabolism*; D066247:Receptor, ErbB-4; D015398:Signal Transduction; D013788:Thalamus / Q000166:cytology* / Q000378:metabolism
D020890:Neuregulin-1; D066246:ErbB Receptors; D066247:Receptor, ErbB-4