[Fibrin gel for treatment of tympanic membrane perforations: an experimental animal model].
BACKGROUND
The goal of this study was to evaluate the effects of a fibrin gel on the healing of tympanic membrane perforation in rats.


METHODS
Prolonged tympanic membrane perforations in 12 rats were created by application of mitomycin C to the intact tympanic membranes followed by bilateral myringotomy. Repeated applications of a fibrin gel to the perforation site of one tympanic membrane were performed in each animal. Tympanic membranes were observed for a total of 8 weeks.


RESULTS
One perforation in each group was already patent at the end of the observation period. The mean healing period of the remaining tympanic membranes was found to be 16.7 days in the fibrin gel group and 19.6 days in the control group.


CONCLUSIONS
A fibrin sheet does not seem to promote the wound healing process of tympanic membranes. However, the sheet might serve as a drug-delivery system for growth factors in the treatment of tympanic membrane perforations, because of its biocompatibility.
Kaftan
H
H
Klinik und Poliklinik für Hals-Nasen- und Ohrenkrankheiten, Kopf- und Halschirurgie, Ernst-Moritz-Arndt-Universität, Walther-Rathenau-Str. 43-45, 17475, Greifswald. H.Kaftan@web.de
Eyrich
D
D
Schindler
E
E
Göpferich
A
A
Hosemann
W
W
D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005782:Gels / Q000008:administration & dosage; D051381:Rats; D014014:Tissue Adhesives / Q000008:administration & dosage; D016896:Treatment Outcome; D018058:Tympanic Membrane Perforation / Q000175:diagnosis / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
D015718:Fibrin Tissue Adhesive; D005782:Gels; D014014:Tissue Adhesives