title: Novel bicyclization reaction leading to a fused beta-lactone.
abstract: [reaction: see text] The reaction of acrylyl chloride with the above amino ketone in the presence of pyridine produces bicyclic beta-lactones rather than the corresponding acrylamide, which can be the major product under other conditions.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000178:Acrylamides; D000577:Amides; D002712:Chlorides; D007783:Lactones; D011725:Pyridines