title: Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.
abstract: Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling.
authors.affiliation: Mary Babb Randolph Cancer Center and Department of Biochemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Brooke
authors.initials: B
authors.lastname: Helfer
authors.forename: Bernard C
authors.initials: BC
authors.lastname: Boswell
authors.forename: Darren
authors.initials: D
authors.lastname: Finlay
authors.forename: Angel
authors.initials: A
authors.lastname: Cipres
authors.forename: Kristiina
authors.initials: K
authors.lastname: Vuori
authors.forename: Tae
authors.initials: T
authors.lastname: Bong Kang
authors.forename: David
authors.initials: D
authors.lastname: Wallach
authors.forename: Andrea
authors.initials: A
authors.lastname: Dorfleutner
authors.forename: Jill M
authors.initials: JM
authors.lastname: Lahti
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Flynn
authors.forename: Steven M
authors.initials: SM
authors.lastname: Frisch
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002154:Calpain / Q000172:deficiency / Q000378:metabolism*; D053181:Caspase 8; D020169:Caspases / Q000172:deficiency / Q000378:metabolism*; D002460:Cell Line; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian; D004789:Enzyme Activation; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D051379:Mice; D018345:Mice, Knockout
chemical_list: D002154:Calpain; C505526:Casp8 protein, mouse; D053181:Caspase 8; D020169:Caspases