title: Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes.
abstract: Vertically aligned yet laterally spaced nanoscale TiO2 nanotubes have been grown on Ti by anodization, and the growth of MC3T3-E1 osteoblast cells on such nanotubes has been investigated. The adhesion/propagation of the osteoblast is substantially improved by the topography of the TiO2 nanotubes with the filopodia of growing cells actually going into the nanotube pores, producing an interlocked cell structure. The presence of the nanotube structure induced a significant acceleration in the growth rate of osteoblast cells by as much as approximately 300-400%.
authors.affiliation: Materials Sciences and Engineering program, Department of Mechanical Aerospace Engineering, University of California at San Diego, La Jolla, California 92093-0411, USA.
authors.forename: Seunghan
authors.initials: S
authors.lastname: Oh
authors.forename: Chiara
authors.initials: C
authors.lastname: Daraio
authors.forename: Li-Han
authors.initials: LH
authors.lastname: Chen
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Pisanic
authors.forename: Rita R
authors.initials: RR
authors.lastname: Fiñones
authors.forename: Sungho
authors.initials: S
authors.lastname: Jin
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D049109:Cell Proliferation; D051379:Mice; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000648:ultrastructure; D010006:Osteoblasts / Q000502:physiology* / Q000648:ultrastructure; D014025:Titanium
chemical_list: C009495:titanium dioxide; D014025:Titanium