title: Distribution of common CARD15 variants in patients with sporadic Crohn's disease: cases from Turkey.
abstract: Three common genetic variations, namely, R702W, G908R, and 1007fs, on CARD15 have been shown to increase the risk for Crohn's disease (CD) in Caucasian populations. In this study the frequencies of these CARD15 variants were determined by genotyping in 56 patients with CD and 100 healthy ethnically matched controls from Turkey. Overall frequency of all three variants was 10.7% in CD patients, compared with 1.5% in controls (odds ratio [OR]: 7.9). Among them, the frequency of the G908R variant allele was 8% in CD cases, compared with 0% in controls (OR: 36.8). The allele frequencies of three CD-related CARD15 variants were considerably lower in the control group compared to the reported Caucasian populations. Among the described CARD15 variants, G908R confers an increased susceptibility to CD, whereas the more frequently reported associations in Europeans with R702W and 1007fs are not confirmed in this Turkish population.
authors.affiliation: Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. aytul@istanbul.edu.tr
authors.forename: F Aytül
authors.initials: FA
authors.lastname: Uyar
authors.forename: Hülya
authors.initials: H
authors.lastname: Over-Hamzaoğlu
authors.forename: Filiz
authors.initials: F
authors.lastname: Türe
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gül
authors.forename: Nurdan
authors.initials: N
authors.lastname: Tözün
authors.forename: Güher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D003424:Crohn Disease / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014421:Turkey / Q000453:epidemiology