title: Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.
abstract: Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
authors.affiliation: Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Bierut
authors.forename: Gerald
authors.initials: G
authors.lastname: Dunne
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Hinrichs
authors.forename: John I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: Raymond
authors.initials: R
authors.lastname: Crowe
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011963:Receptors, GABA-A / Q000235:genetics*; D019966:Substance-Related Disorders / Q000235:genetics
chemical_list: C484841:GABRA2 protein, human; D011963:Receptors, GABA-A; D004247:DNA