title: Anti-inflammatory and antinociceptive activity of flavonoids isolated from Viscum album ssp. album.
abstract: Viscum album L. has been used in the indigenous systems of medicine for treatment of headache and some inflammatory diseases. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the five flavonoids (5,7-dimethoxy naringenin or 4',6'-dimethoxy chalcononaringenin) derivatives, isolated from the ethyl acetate fraction of the extract from V. album ssp. album, were investigated, namely 5,7-dimethoxy-flavanone-4'-O-beta-D-glucopyranoside (1), 2'-hydroxy-4',6'-dimethoxy-chalcone-4-O-beta-D-glucopyranoside (2), 5,7-dimethoxy-flavanone-4'-O-[2"-O-(5"'-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (3), 2'-hydroxy-4',6'-dimethoxy-chalcone-4-O-[2"-O-(5"'-O-trans-cinnamoyl)-beta-Dapiofuranosyl]-beta-D-glucopyranoside (4), 5,7-dimethoxy-flavanone-4'-O-[beta-D-apiofuranosyl-(1 --> 2)]-beta-D-glucopyranoside (5). For the antinociceptive activity assessment the p-benzoquinone-induced writhing test and for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice were used. The ethyl acetate fraction in a dose of 250 mg/kg as well as compounds 2 and 5 in a 30 mg/kg dose were shown to possess remarkable antinociceptive and anti-inflammatory activities per os without inducing any apparent acute toxicity as well as gastric damage.
authors.affiliation: Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, 06330 Etiler, Ankara, Turkey.
authors.forename: Didem Deliorman
authors.initials: DD
authors.lastname: Orhan
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli
authors.forename: Erdem
authors.initials: E
authors.lastname: Yesilada
authors.forename: Fatma
authors.initials: F
authors.lastname: Ergun
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy; D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001530:Belgium; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D006614:Hindlimb; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D028182:Viscum album / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010936:Plant Extracts; D002351:Carrageenan; D001241:Aspirin; D007213:Indomethacin