The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice.
We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.
Delogu
Giovanni
G
Institute of Microbiology, Catholic University of the Sacred Hearth, Largo Gemelli 8, 00168 Rome, Italy. gdelogu@rm.unicatt.it
Sanguinetti
Maurizio
M
Posteraro
Brunella
B
Rocca
Stefano
S
Zanetti
Stefania
S
Fadda
Giovanni
G
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D008168:Lung / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D011994:Recombinant Proteins / Q000096:biosynthesis; D013154:Spleen / Q000378:metabolism* / Q000382:microbiology; D015854:Up-Regulation
D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; C440647:HbhA protein, Mycobacterium tuberculosis; D008565:Membrane Proteins; D011994:Recombinant Proteins