title: The genotypic inhibitory quotient and the (cumulative) number of mutations predict the response to lopinavir therapy.
abstract: For 95 protease inhibitor-experienced HIV-1-infected patients, the genotypic inhibitory quotient (GIQ; trough level/number of mutations) was calculated for lopinavir. Three different sets of mutations showed equal predictive value. However, the use of cumulative numbers of mutations for calculation of the GIQ showed significantly better association with the virological response. Furthermore, the predictive value of the GIQ was no different from that of the number of mutations alone.
authors.affiliation: Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, the Netherlands.
authors.forename: Jolanda G M
authors.initials: JG
authors.lastname: Hoefnagel
authors.forename: Manon J
authors.initials: MJ
authors.lastname: van der Lee
authors.forename: Peter P
authors.initials: PP
authors.lastname: Koopmans
authors.forename: Rob
authors.initials: R
authors.lastname: Schuurman
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jurriaans
authors.forename: Ard I
authors.initials: AI
authors.lastname: van Sighem
authors.forename: Luuk
authors.initials: L
authors.lastname: Gras
authors.forename: Frank
authors.initials: F
authors.lastname: de Wolf
authors.forename: Jochem M D
authors.initials: JM
authors.lastname: Galama
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
mesh_terms: D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000097:blood / Q000627:therapeutic use*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D061466:Lopinavir; D009154:Mutation; D011744:Pyrimidinones / Q000097:blood / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects / Q000235:genetics
chemical_list: D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir