Four cases of Graves' disease which developed after painful Hashimoto's thyroiditis.
We report four cases of Graves' disease that developed after painful Hashimoto's thyroiditis. All were middle-aged women, who had high titers of anti-thyroid antibodies and thyrotoxicosis at the onset of painful Hashimoto's thyroiditis. After 2 to 7 years, they developed Graves' disease with positive antibody against the thyrotropin receptor. Their clinical courses of Graves' disease went favorably due to the treatment with antithyroid drug or radioactive iodine therapy. Painful Hashimoto's thyroiditis is an atypical variant of Hashimoto's thyroiditis and is one form of destructive thyroiditis. Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease.
Ohye
Hidemi
H
Department of Internal Medicine, Kuma Hospital, Kobe.
Nishihara
Eijun
E
Sasaki
Ichiro
I
Kubota
Sumihisa
S
Fukata
Shuji
S
Amino
Nobuyuki
N
Kuma
Kanji
K
Miyauchi
Akira
A
D013956:Antithyroid Agents / Q000008:administration & dosage; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006111:Graves Disease / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008713:Methimazole / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D013960:Thyroid Function Tests
D013956:Antithyroid Agents; D005938:Glucocorticoids; D008713:Methimazole; D002097:C-Reactive Protein; D011239:Prednisolone