Novel susceptibility genes in inflammatory bowel disease.
The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed.
Noble
Colin
C
Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, United Kindgom. cnoble1@staffmail.ed.ac.uk
Nimmo
Elaine
E
Gaya
Daniel
D
Russell
Richard K
RK
Satsangi
Jack
J
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D054418:Chemokine CCL20; D019742:Chemokines, CC / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D019402:Macrophage Inflammatory Proteins / Q000235:genetics; D053474:Nod1 Signaling Adaptor Protein; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics; D051197:Toll-Like Receptor 4 / Q000235:genetics; D051198:Toll-Like Receptor 5 / Q000235:genetics; D020798:Two-Hybrid System Techniques
D048868:Adaptor Proteins, Signal Transducing; C108355:CCL20 protein, human; D054418:Chemokine CCL20; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein; C495345:TLR4 protein, human; C495346:TLR5 protein, human; D051197:Toll-Like Receptor 4; D051198:Toll-Like Receptor 5