Risk factors for death in acquired immunodeficiency syndrome-associated disseminated histoplasmosis.
We performed a retrospective study of 164 human immunodeficiency virus (HIV)-infected patients with disseminated histoplasmosis to identify the risk factors for death. Death occurred in 32% of the cases. Univariate analysis identified the following risk factors: diarrhea (odds ratio [OR] = 3.9, P = 0.001), neurologic manifestations (OR = 5.8, ; P = 0.001), hemoglobin level < 8.0g/dL (OR = 2.7, P = 0.004), urea level 2 times the normal upper limit (OR = 5.0, P < 0.001), creatinine level > 1.5 mg/dL (OR = 2.9, P = 0.005), aspartate aminotransferase (AST) level > 2.5 times the normal upper limit (OR = 3.1, P = 0.01), respiratory insufficiency (OR = 9.7, P < 0.001), sepsis (OR = 20.2, P < 0.001), and acute renal failure (OR = 2.5, P = 0.011). A hemoglobin level < 8.0 g/dL (OR = 3.8, P = 0.008), an AST level >or= 2.5 times the normal limit (OR = 1.0, P = 0.007), acute renal failure (OR = 2.96, P = 0.015), and respiratory insufficiency (OR = 12.2, P = 0.01) were independent risk factors for death.
de Francesco Daher
Elizabeth
E
Department of Internal Medicine, Faculdade de Medicina, Hospital Universitário Walter Cantídio. efdaher@for.terra.com.br
de Sousa Barros
Fernando Antonio
FA
da Silva Júnior
Geraldo Bezerra
GB
Takeda
Christianne Fernandes Valente
CF
Mota
Rosa Maria Salani
RM
Ferreira
Marúsia Thomaz
MT
Martins
Julieta Cunha
JC
Oliveira
Soraya Alves Jacinto
SA
Gutiérrez-Adrianzén
Oswaldo Augusto
OA
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D001774:Blood Chemical Analysis; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006660:Histoplasmosis / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors