title: The relation between tumor marker Ca 15-3 and metastases in interpectoral lymph nodes in breast cancer patients.
abstract: OBJECTIVE
  We aimed at analyzing the metastatic involvement in interpectoral (Rotter's) lymph nodes (RLN) in relation to tumor marker CA 15-3.
  
  
  METHODS
  The study included 177 female patients undergoing surgery for primary breast cancer at the University Hospital for Tumors, Zagreb, Croatia from November 2001 to March 2004. In addition to the standard surgical procedure, interpectoral RLNs were removed in all of the patients. Levels of the serum tumor marker CA 15-3 was determined prior to surgery.
  
  
  RESULTS
  Rotter's lymph nodes were identified in 66.2% of the patients, with metastatic involvement revealed in 18.6% of the RLNs. Metastatic involvement of RLNs in patients with negative axillary lymph nodes was 2.8% and positive in 34.6%. Elevated serum levels of tumor marker CA 15-3 had 22 (12.4%) patients. Of 33 Rotter's node-positive patients, 27.3% had elevated serum levels of tumor marker CA 15-3 and in Rotter's node-negative patients only 9% had elevated serum levels of tumor marker CA 15-3, with the level statistically significantly higher in Rotter's positive patients compared to those with negative (or absent) RLNs (chi2=8.22, p=0.004).
  
  
  CONCLUSIONS
  Tumor marker CA 15-3 is more frequently elevated in patients with positive RLNs. Elevated values of tumor marker CA 15-3 could be warning for possible positive interpectoral nodes. The removal of the RLNs may be beneficial for patients with (massive) axillary nodal involvement. For axillary node negative patients, sentinel node biopsy could avoid the unnecessary removal of the RLNs.
authors.affiliation: Department of Surgical Oncology, University Hospital for Tumors, Ilica 197, Zagreb 10 000, Croatia. d.v.vrdoljak@kzt.hr
authors.forename: Danko V
authors.initials: DV
authors.lastname: Vrdoljak
authors.forename: Fabijan
authors.initials: F
authors.lastname: Knezevic
authors.forename: Vesna
authors.initials: V
authors.lastname: Ramljak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology*; D002277:Carcinoma / Q000097:blood* / Q000556:secondary*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*
chemical_list: D018396:Mucin-1