Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes.
Information on the functional genomics of Caenorhabditis elegans has increased significantly in the last few years with the development of RNA interference. In parasitic nematodes, RNA interference has shown some success in gene knockdown but optimisation of this technique will be required before it can be adopted as a reliable functional genomics tool. Comparative studies in C. elegans remain an appropriate alternative for studying the function and regulation of some parasite genes and will be extremely useful for fully exploiting the increasing parasite genome sequence data becoming available.
Britton
Collette
C
Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK. c.britton@vet.gla.ac.uk
Murray
Linda
L
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D017238:Genes, Helminth / Q000502:physiology*; D034622:RNA Interference; D018510:RNA, Helminth / Q000235:genetics
D018510:RNA, Helminth