title: Cytotoxic constituents of Achillea clavennae from Montenegro.
abstract: Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.
authors.affiliation: Faculty of Chemistry, University of Belgrade, Serbia and Montenegro.
authors.forename: Snezana
authors.initials: S
authors.lastname: Trifunović
authors.forename: Vlatka
authors.initials: V
authors.lastname: Vajs
authors.forename: Zorica
authors.initials: Z
authors.lastname: Juranić
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Zizak
authors.forename: Vele
authors.initials: V
authors.lastname: Tesević
authors.forename: Slobodan
authors.initials: S
authors.lastname: Macura
authors.forename: Slobodan
authors.initials: S
authors.lastname: Milosavljević
mesh_terms: D031162:Achillea / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival; D002478:Cells, Cultured; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015022:Yugoslavia
chemical_list: D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane; C083161:centaureidin