[The role of tumor necrosis factor (TNF-alpha) in control of metabolism].
Tumor necrosis factor is multifunctional cytokine involved in various cell functions, such as differentiation, mitosis, angiogenesis, inflammation and immune controls. TNF-alpha plays also an important role in the control of metabolism. Its action on adipocytes includes increasing secretion of triglicerydes and inhibiting insulin action, controlling expression of some genes and modulating free fatty acid and leptin secretion. The review of the current literature on the TNF-alpha role in metabolism is presented in this paper.
Olszanecka-Glinianowicz
Magdalena
M
Katedry Patofizjologii Sla,skiej Akademii Medycznej, Katowicach. magols@esculap.pl
Zahorska-Markiewicz
Barbara
B
Zurakowski
Aleksander
A
Glinianowicz
Mariusz
M
D000273:Adipose Tissue / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008066:Lipolysis / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D014409:Tumor Necrosis Factor-alpha