Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.
Vandromme
Lucie
L
UMR 176 CNRS-Institut Curie, Institut Curie Section de Recherche, Bât. 110, Centre Universitaire, 91405 Orsay, France.
Piguel
Sandrine
S
Lozach
Olivier
O
Meijer
Laurent
L
Legraverend
Michel
M
Grierson
David S
DS
D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051360:Cyclin-Dependent Kinase 5 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D047428:Protein Kinase Inhibitors; D011687:Purines; D051360:Cyclin-Dependent Kinase 5; D016203:CDC2 Protein Kinase; D038362:Glycogen Synthase Kinase 3; C030985:purine