Clinical efficacy of body mass index as predictor of in vitro fertilization and embryo transfer outcomes.
The aim of this study was to evaluate the clinical efficacy of body mass index (BMI) as a predictor of in vitro fertilization and embryo transfer (IVF-ET) outcomes. Two hundred twenty-three IVF-ET cycles in 164 patients under 37 yr using GnRH agonist long protocols were included in this retrospective study. All of the selected cases were divided into two groups by a cutoff of 24 kg/m2 and these two groups were compared in regard to the outcomes of IVF-ET. There were no significant differences between group 1 (BMI <24 kg/m2) and group 2 (BMI > or = 24 kg/m2) in age, basal serum FSH level, estradiol (E2) level and endometrial thickness on hCG day, number of retrieved oocytes and transferred embryos. However, higher doses of gonadotropins were used in group 2 (30.8+/-12.7 ampoules vs. 35.4+/-15.3 ampoules, p=0.051). The clinical pregnancy rate was significantly lower in group 2 (25.9% vs. 10.5%, p=0.041) and implantation rate tended to be lower in group 2 (12.7% vs. 6.8%, p=0.085). BMI > or = 24 kg/m2 can be a candidate prognosticator of IVF-ET outcomes.
Ku
Seung Yup
SY
Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University, Chongno-gu, Seoul, Korea.
Kim
Sang Don
SD
Jee
Byung Chul
BC
Suh
Chang Suk
CS
Choi
Young Min
YM
Kim
Jung Gu
JG
Moon
Shin Yong
SY
Kim
Seok Hyun
SH
D000328:Adult; D015992:Body Mass Index; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000473:pathology / Q000628:therapy; D009765:Obesity / Q000150:complications / Q000473:pathology; D011247:Pregnancy; D011379:Prognosis; D016896:Treatment Outcome