Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone.
Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the second phase of nociceptive response induced by formaldehyde (0.34%, 20 microl) in mice, but only the highest dose inhibited the first phase of this response. The thermal hyperalgesia and mechanical allodynia induced by carrageenan (1%, 50 microl, i.pl.) in rats were also inhibited by BS (50 mg/kg, i.p.). However, treatment of mice with BS did not induce an antinociceptive effect in the hot-plate model. The paw edema induced by carrageenan (1%, 50 microl, i.pl.) in rats was inhibited by BS (25 or 50 mg/kg, i.p.). Treatment of mice with BS (0.25, 0.5 or 2.5 mg/kg/day, i.p., 7 days) also inhibited angiogenesis induced by subcutaneous implantation of a sponge disc. It is unlikely that the antinociceptive effect induced by BS results from motor incoordination or a muscle relaxing effect, as the mice treated with this drug displayed no behavioral impairment in the rotarod apparatus. In conclusion, we demonstrated that BS presents antinociceptive, antiedematogenic and antiangiogenic activities. An extensive investigation of the pharmacological actions of BS and its derivatives is justified and may lead to the development of new clinically useful drugs.
Rocha
Leonardo Tadeu S
LT
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil.
Costa
Karina A
KA
Oliveira
Antônio Carlos P
AC
Nascimento
Elias B
EB
Bertollo
Caryne M
CM
Araújo
Fernanda
F
Teixeira
Letícia R
LR
Andrade
Sílvia P
SP
Beraldo
Heloisa
H
Coelho
Márcio M
MM
D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy*; D005557:Formaldehyde / Q000494:pharmacology; D006930:Hyperalgesia / Q000188:drug therapy; D008297:Male; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D045442:Rotarod Performance Test; D012664:Semicarbazones / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
D001547:Benzaldehydes; D012664:Semicarbazones; C512112:benzaldehyde semicarbazone; D005557:Formaldehyde; D002351:Carrageenan; C032175:benzaldehyde