title: Increased oxidative stress and oxidative damage associated with chronic bacterial prostatitis.
abstract: OBJECTIVE
  To investigate whether chronic bacterial prostatitis might increase oxidative stress and oxidative damage in chronic bacterial prostatitis patients (CBPP), and to explore its possible mechanism.
  
  
  METHODS
  Enrolled in a case-control study were 70 randomly sampled CBPP and 70 randomly sampled healthy adult volunteers (HAV), on whom plasma nitric oxide (NO), vitamin C (VC), vitamin E (VE) and beta-carotene (beta-CAR) level, erythrocyte malondialdehyde (MDA) level, as well as erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities were determined by spectrophotometry.
  
  
  RESULTS
  Compared with the HAV group, values of plasma NO and erythrocyte MDA in the CBPP group were significantly increased (P < 0.001); those of plasma VC, VE and beta-CAR as well as erythrocyte SOD, CAT and GPX activities in the CBPP group were significantly decreased (P < 0.001). Findings from partial correlation for the 70 CBPP showed that with prolonged course of disease, values of NO and MDA were gradually increased (P < 0.001), and those of VC, VE, beta-CAR, SOD, CAT and GPX were gradually decreased (P < 0.05-0.001). The findings from stepwise regression for the 70 CBPP suggested that the model was Y = -13.2077 + 0.1894MDA + 0.0415NO - 0.1999GPX, F = 18.2047, P < 0.001, r = 0.6729, P < 0.001.
  
  
  CONCLUSIONS
  The findings suggest that there exist increased oxidative stress and oxidative damage induced by chronic bacterial prostatitis in the patients, and such phenomenon was closely related to the course of disease.
authors.affiliation: Laboratory for Free Radical Medicine, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China. jfzhou@zju.edu.cn
authors.forename: Jun-Fu
authors.initials: JF
authors.lastname: Zhou
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Xiao
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000097:blood; D001424:Bacterial Infections / Q000097:blood / Q000503:physiopathology*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011472:Prostatitis / Q000097:blood / Q000382:microbiology* / Q000503:physiopathology; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D019207:beta Carotene; D014810:Vitamin E; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid