title: Gender-related differences in target organ damage in untreated patients with essential hypertension.
abstract: We examined the gender-related differences in target organ damage in 220 untreated patients with essential hypertension (106 men and 114 women). As the indices of target organ damage, we examined the left ventricular mass index and the intima-media thickness in the carotid and femoral arteries obtained from echocardiography. In a multiple regression model, there was a significant positive correlation between the intima-media thickness and age in both groups. In men, there was a significant positive correlation between the left ventricular mass index and age, as well as the diastolic blood pressure, and body mass index. In women, there was a significant positive correlation between the left ventricular mass index and age, as well as plasma renin activity and smoking. In conclusion, there are gender-related differences in the contributing factors, which relate to left ventricular hypertrophy in patients with essential hypertension.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Nishio Municipal Hospital, Nishio.
authors.forename: Makoto
authors.initials: M
authors.lastname: Saitoh
authors.forename: Hideya
authors.initials: H
authors.lastname: Nishimura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Teruo
authors.initials: T
authors.lastname: Kondoh
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000473:pathology; D005260:Female; D005263:Femoral Artery / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology