[Guideline on the use of corticosteroids in Duchenne muscular dystrophy from paediatric neurologists, neurologists and rehabilitation physicians].
A guideline on the treatment of boys with muscular dystrophy with corticosteroids has been written and is available from the Dutch patients' organization. The guideline has been approved by the Dutch Societies of Neurology, Rehabilitation and Paediatrics. Based on the available literature the advice is to treat the boys with corticosteroids as soon as they become symptomatic. Prednisone is the drug ofchoice. The recommended dosage is 0.75 mg/kg body weight/day, every day or in a schedule of 10 days with treatment and 10 days without. From the initiation of the prednisone treatment dietary advice is given to control body weight. Monitoring for adverse effects takes place regularly.
de Groot
I J M
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Universitair Medisch Centrum St Radboud, afd. Revalidatiegeneeskunde, HP 898, Postbus 9101, 6500 HB Nijmegen.
D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy*; D009426:Netherlands; D017410:Practice Guidelines as Topic; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use*; D015430:Weight Gain / Q000187:drug effects
D005938:Glucocorticoids; D011241:Prednisone