Zaleplon (Sonata) oral sedation for outpatient third molar extraction surgery.
Zalpelon was compared with triazolam for oral sedation in a third molar surgery model using a double-blind crossover design. Factors such as anxiolysis, amnesia, and quality of sedation were assessed. Of the 14 participants who completed the study, zaleplon sedation was found to be similar to triazolam sedation in all regards except that recovery from zaleplon was more rapid.
Ganzberg
Steven I
SI
Department of Dental Anesthesiology, Children's Hospital, Ohio State University College of Dentistry, Columbus, Ohio 43205, USA. ganzbers@chi.osu.edu
Dietrich
Thomas
T
Valerin
Manuel
M
Beck
F Michael
FM
D000081:Acetamides / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001007:Anxiety / Q000517:prevention & control; D016292:Procedural Sedation; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008568:Memory / Q000187:drug effects; D008964:Molar, Third / Q000601:surgery*; D011743:Pyrimidines / Q000008:administration & dosage*; D014081:Tooth Extraction; D014229:Triazolam / Q000627:therapeutic use
D000081:Acetamides; D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; D014229:Triazolam; C085665:zaleplon