title: Chromatographic and mass spectral studies on methoxymethcathinones related to 3,4-methylenedioxymethamphetamine.
abstract: The methoxymethcathinones are uniquely regioisomeric with the controlled drug substance 3,4-methylenedioxymethamphetamine (3,4-MDMA) or Ecstacy. The various isomeric forms of the methoxymethcathinones have mass spectra essentially equivalent to 3,4-MDMA. They all have a molecular weight of 193 and major fragment ions in their electron ionization mass spectra at m/z 58 and 135/136. Differentiation by mass spectrometry was only possible after formation of the perfluoroacyl derivatives, pentafluoropropionylamides (PFPA), and heptafluorobutrylamides (HFBA). Gas chromatographic separation on nonpolar stationary phases successfully resolved the three methcathinones from 2,3- and 3,4-MDMA as the PFPA and HFBA derivatives.
authors.affiliation: Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
authors.forename: Tamer
authors.initials: T
authors.lastname: Awad
authors.forename: C Randall
authors.initials: CR
authors.lastname: Clark
authors.forename: Jack
authors.initials: J
authors.lastname: DeRuiter
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000737:chemistry*; D011427:Propiophenones / Q000737:chemistry*
chemical_list: D011427:Propiophenones; C047806:monomethylpropion; D018817:N-Methyl-3,4-methylenedioxyamphetamine