title: Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome.
abstract: Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The mean volume of intravenous fluid used was 110.4 mL/kg administered over a mean period of 25.8 hours. The mean volumes of intravenous fluid replacement in infants with DSS was significantly higher than in those with non-shock DHF (129.8 mL/kg versus 102.1 mL/kg; P = 0.001). Patients with DSS had significantly higher proportional requirements for dextran and blood transfusions than non-shock infants. Recurrent shock, prolonged shock, and acute respiratory failure were recorded in 8, 6, and 13 patients, respectively. Four patients with DSS died of severe complications. Intravenous fluid replacement with special care to avoid fluid overload requires careful attention to established indications for use of colloidal solutions and blood transfusions. To improve case fatality rates, special efforts need to be directed to infants with DHF/DSS accompanied by severe complications.
authors.affiliation: Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam. hungdhf@hcm.fpt.vn
authors.forename: Thanh Hung
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Trong Lan
authors.initials: TL
authors.lastname: Nguyen
authors.forename: Huan-Yao
authors.initials: HY
authors.lastname: Lei
authors.forename: Yee-Shin
authors.initials: YS
authors.lastname: Lin
authors.forename: Bich Lien
authors.initials: BL
authors.lastname: Le
authors.forename: Kao-Jean
authors.initials: KJ
authors.lastname: Huang
authors.forename: Chiou-Feng
authors.initials: CF
authors.lastname: Lin
authors.forename: Quang Ha
authors.initials: QH
authors.lastname: Do
authors.forename: Thi Que Huong
authors.initials: TQ
authors.lastname: Vu
authors.forename: Thi My
authors.initials: TM
authors.lastname: Lam
authors.forename: Trai-Ming
authors.initials: TM
authors.lastname: Yeh
authors.forename: Jyh-Hsiung
authors.initials: JH
authors.lastname: Huang
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Liu
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
mesh_terms: D001803:Blood Transfusion; D003911:Dextrans / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D017063:Outcome Assessment, Health Care; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011446:Prospective Studies; D019595:Severe Dengue / Q000473:pathology / Q000628:therapy*; D012720:Severity of Illness Index; D014744:Vietnam
chemical_list: D003911:Dextrans; D010952:Plasma Substitutes