CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity.
The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.
Shim
Eunsook
E
School of Biological Sciences, College of Natural Sciences, Kangwon National University, 200-701, Chunchon, Republic of Korea.
Shim
Hyeeun
H
Bae
Jinhee
J
Lee
Hansoo
H
Jeoung
Dooil
D
D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000378:metabolism*; D008213:Lymphocyte Activation; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology*
D017382:Reactive Oxygen Species; C454199:DDX53 protein, human; D053487:DEAD-box RNA Helicases