title: Identification of novel PPARalpha ligands by the structural modification of a PPARgamma ligand.
abstract: To develop novel PPARalpha ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives. Compound 10, the meta isomer of a PPARgamma agonist 1, has been identified as a PPARalpha ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARalpha-binding potency.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Usui
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fujieda
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yoshida
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D047493:PPAR alpha / Q000737:chemistry* / Q000378:metabolism*; D047495:PPAR gamma / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D047493:PPAR alpha; D047495:PPAR gamma