title: A colorimetric boronic acid based sensing ensemble for carboxy and phospho sugars.
abstract: [structure: see text] A cadmium-centered tris-boronic acid receptor was synthesized, and its binding properties toward various anionic sugars were determined. This receptor shows high affinity for different anionic sugars, especially gluconic acid, which has an association constant near approximately 10(7) M(-)(1) at neutral pH. Further, using an indicator displacement assay, a color change of pyrocatechol violet was observed upon addition of anionic sugars. This colorimetric test was used as a facile screening technique to qualitatively analyze guest affinities.
authors.affiliation: Department of Chemistry and Biochemistry, 1 Longhorn Way, A5300, The University of Texas, Austin, Texas 78712, USA.
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Zhang
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002104:Cadmium / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D003124:Colorimetry / Q000379:methods*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013403:Sugar Phosphates / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D013403:Sugar Phosphates; D002104:Cadmium