title: The effect of mechanical bowel preparation on colonic anastomotic healing: an experimental study.
abstract: OBJECTIVE
  Although bowel preparation is traditionally used in elective colorectal surgery, its value is debatable. The aim of this study was to evaluate the influence of mechanical bowel preparation on healing of colonic anastomoses.
  
  
  METHODS
  Twenty-seven rats were divided into three groups, each of nine animals. All rats had left colonic resection and anastomosis. Group 1 and group 2 were the control and sham group, respectively. Group 3 had colonic lavage before resection and anastomosis. On the fourth postoperative day, animals were killed; bursting pressure and tissue hydroxyproline concentrations were measured and compared.
  
  
  RESULTS
  The median bursting pressure values were 87 (range 4-135) mmHg in group 1, 88 (range 78-136) mmHg in group 2 and 76.0 (range 57.0-125) mmHg in group 3. The differences between bursting pressure values of the groups were not statistically significant (p= 0.07). The median tissue hydroxyproline concentrations were 3.25 (range 2.63-5.16) mg/mg in group 1, 4.15 (range 1.54-5.72) mg/mg in group 2 and 3.52 (range 2.04-5.27) mg/mg in group 3. The differences between tissue hydroxyproline concentrations of the groups were not statistically significant (p = 0.7).
  
  
  CONCLUSIONS
  Mechanical bowel preparation is not necessary for enhancing colonic anastomotic integrity in the rat.
authors.affiliation: Department of Surgery, Ankara Oncology Hospital, Ankara, Turkey. hhakanmersin@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Mersin
authors.forename: H
authors.initials: H
authors.lastname: Bulut
authors.forename: U
authors.initials: U
authors.lastname: Berberoglu
mesh_terms: D000704:Analysis of Variance; D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D003082:Colectomy / Q000379:methods*; D005260:Female; D007430:Intraoperative Care; D051381:Rats; D017208:Rats, Wistar; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D007507:Therapeutic Irrigation; D014945:Wound Healing