title: Association between dietary fiber and serum C-reactive protein.
abstract: BACKGROUND
  High sensitivity C-reactive protein (CRP) is a marker of acute inflammation recently recognized as an independent predictor of future cardiovascular disease and diabetes. The identification of modifiable factors, such as diet, that influence serum CRP concentrations may provide the means for reducing the risk of these diseases. Data on longitudinal associations between dietary fiber intake and CRP are currently lacking.
  
  
  OBJECTIVE
  The purpose of this study was to examine longitudinal associations between dietary fiber intake and CRP.
  
  
  METHODS
  Data collection took place at baseline and quarterly (every 13 wk) thereafter for a total of 5 visits, each including measurements of body composition, CRP, diet, and physical activity. Relations between serum CRP and dietary fiber were assessed by using linear mixed models and logistic regression, adjusted for covariates.
  
  
  RESULTS
  A total of 524 subjects had multiple measurements of CRP and dietary factors. The average total dietary fiber intake was 16.11 g/d. Average serum CRP was 1.78 mg/L. We observed an inverse association between intake of total dietary fiber (separately for soluble and insoluble fiber) and CRP concentrations in both cross-sectional and longitudinal analyses. The likelihood of elevated CRP concentrations was 63% lower (OR: 0.37; 95% CI: 0.16, 0.87) in participants in the highest quartile of total fiber intake than in participants in the lowest quartile.
  
  
  CONCLUSIONS
  Our results suggest that dietary fiber is protective against high CRP, which supports current recommendations for a diet high in fiber.
authors.affiliation: Division of Preventive and Behavioral Medicine and the Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. yunsheng.ma@umassmed.edu
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Ma
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Griffith
authors.forename: Lisa
authors.initials: L
authors.lastname: Chasan-Taber
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Olendzki
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Jackson
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Stanek
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Pagoto
authors.forename: Andrea R
authors.initials: AR
authors.lastname: Hafner
authors.forename: Ira S
authors.initials: IS
authors.lastname: Ockene
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D004043:Dietary Fiber / Q000008:administration & dosage*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012995:Solubility
chemical_list: D015415:Biomarkers; D004043:Dietary Fiber; D002097:C-Reactive Protein