title: The epimerization of peptide aldehydes--a systematic study.
abstract: Peptide aldehydes are interesting targets as enzyme inhibitors, and can be used for pseudopeptide chemistry or ligation. However, they are known to be subjected to epimerization during synthesis or purification. By (1)H NMR, a model dipeptide aldehyde can be used to check the possible epimerization occurring during synthesis. Various purification methods were investigated, but none was free from epimerization.
authors.affiliation: Laboratoire des Aminoacides, Peptides et Protéines, LAPP, UMR 5810 CNRS Universités Montpellier I et II, Faculté de Pharmacie, 15 Avenue Charles Flahault,BP 14491, 34093 Montpellier Cédex 5, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Ganneau
authors.forename: Aline
authors.initials: A
authors.lastname: Moulin
authors.forename: Luc
authors.initials: L
authors.lastname: Demange
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Jean-Alain
authors.initials: JA
authors.lastname: Fehrentz
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000595:Amino Acid Sequence; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D009842:Oligopeptides