title: Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA.
abstract: Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. The interaction modes of quercetins with monomeric and dimeric G-quadruplexes were studied by absorption, fluorescence, CD, and (1)H NMR spectroscopies. The ligands were found to be stacked with terminal tetrads of monomeric G-quadruplexes by intercalation and bound to dimeric G-quadruplexes by groove binding.
authors.affiliation: Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Sun
authors.forename: Yalin
authors.initials: Y
authors.lastname: Tang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xiang
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Xu
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Lianghua
authors.initials: L
authors.lastname: Xu
mesh_terms: D001665:Binding Sites; D002942:Circular Dichroism / Q000379:methods; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D054856:G-Quadruplexes; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry* / Q000494:pharmacology*; D012015:Reference Standards; D013050:Spectrometry, Fluorescence / Q000379:methods; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D004247:DNA; D011794:Quercetin