title: Fluoroquinolone resistance in Ureaplasma parvum in the United States.
abstract: We report the first case of naturally occurring fluoroquinolone resistance in Ureaplasma spp. from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure.
authors.affiliation: Department of Pathology, WP 230, 619 19th St. South, University of Alabama at Birmingham, Birmingham, AL 35226, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Duffy
authors.forename: John
authors.initials: J
authors.lastname: Glass
authors.forename: Geraldine
authors.initials: G
authors.lastname: Hall
authors.forename: Robin
authors.initials: R
authors.lastname: Avery
authors.forename: Raymond
authors.initials: R
authors.lastname: Rackley
authors.forename: Scott
authors.initials: S
authors.lastname: Peterson
authors.forename: Ken
authors.initials: K
authors.lastname: Waites
mesh_terms: D000328:Adult; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D014481:United States; D014509:Ureaplasma / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology
chemical_list: D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase