title: Microarray-based understanding of normal and malignant plasma cells.
abstract: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.
authors.affiliation: IRB, CHU Montpellier, Montpellier, France.
authors.forename: John
authors.initials: J
authors.lastname: De Vos
authors.forename: Dirk
authors.initials: D
authors.lastname: Hose
authors.forename: Thierry
authors.initials: T
authors.lastname: Rème
authors.forename: Karin
authors.initials: K
authors.lastname: Tarte
authors.forename: Jérôme
authors.initials: J
authors.lastname: Moreaux
authors.forename: Karéne
authors.initials: K
authors.lastname: Mahtouk
authors.forename: Michel
authors.initials: M
authors.lastname: Jourdan
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Rossi
authors.forename: Friedrich W
authors.initials: FW
authors.lastname: Cremer
authors.forename: Bernard
authors.initials: B
authors.lastname: Klein
mesh_terms: D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010265:Paraproteinemias / Q000235:genetics*; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism