Anti-ganglioside complex antibodies in Miller Fisher syndrome.
BACKGROUND
Some ganglioside complexes (GSCs) are target antigens for serum antibodies in patients with Guillain-Barré syndrome (GBS). Anti-GSC antibodies may be associated with particular clinical features of GBS.


OBJECTIVE
To investigate antibodies to GSCs in the sera of patients with Miller Fisher syndrome (MFS) characterised by elevation of the IgG anti-GQ1b antibody.


RESULTS
In all, 7 of 12 (58%) consecutive patients with MFS were found to have IgG antibodies to GSCs containing GQ1b, of whom 5 had IgG antibodies to GQ1b-GM1 complex (GQ1b/GM1) and 2 had antibodies to GQ1b/GD1a; 4 of 5 patients without sensory symptoms had anti-GQ1b/GM1 antibodies.


CONCLUSIONS
At least three different specificities in MFS-associated antibodies, GQ1b-specific, anti-GQ1b/GM1-positive and anti-GQ1b/GD1a-positive, were observed. In patients with MFS not only GQ1b itself but also clustered epitopes of GSCs, including GQ1b, may be considered to be prime target antigens for serum antibodies. A tendency to escape sensory disturbances is shown by anti-GQ1b/GM1-positive MFS.
Kaida
K
K
Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama-Ken, Japan.
Kanzaki
M
M
Morita
D
D
Kamakura
K
K
Motoyoshi
K
K
Hirakawa
M
M
Kusunoki
S
S
D000328:Adult; D000368:Aged; D001323:Autoantibodies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000097:blood* / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D005732:Gangliosides; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside