Synthetic diether-linked cationic lipids for gene delivery.
Quaternary ammonium lipids 2a-p, with diether linkages between hydrocarbon chains and their ammonium headgroups, were synthesized as potential vectors for cationic liposome-mediated gene delivery. Varying the length of carbon chains and quaternary ammonium heads as well as different anionic complexes will enable the study of the structure-function relationships of these cationic lipids in terms of gene delivery properties.
Liu
Dongliang
D
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Zhongshan Road 158th, Dalian, 116012, China. dut_liud@yahoo.com.cn
Qiao
Weihong
W
Li
Zongshi
Z
Zhang
Shubiao
S
Cheng
Lvbo
L
Jin
Kun
K
D000838:Anions; D002412:Cations; D004337:Drug Carriers / Q000138:chemical synthesis*; D004987:Ethers / Q000138:chemical synthesis; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes / Q000138:chemical synthesis; D010957:Plasmids / Q000138:chemical synthesis; D000644:Quaternary Ammonium Compounds; D055672:Static Electricity; D014162:Transfection / Q000379:methods*
D000838:Anions; D002412:Cations; D004337:Drug Carriers; D004987:Ethers; D008055:Lipids; D008081:Liposomes; D000644:Quaternary Ammonium Compounds