title: First two successful unrelated donor bone marrow transplantations for paroxysmal nocturnal hemoglobinuria in Poland.
abstract: OBJECTIVE
  The experience with bone marrow transplantation (BMT) from matched unrelated donors (MUD) for paroxysmal nocturnal hemoglobinuria (PNH) is limited and optimal preparative regimen has been not established.
  
  
  METHODS
  We report first two MUD BMTs for patients with PNH in Poland. Preparative regimen consisted of Treosulfan, Fludarabine and Thymoglobulin. We also present the review of published reports on allogeneic transplantations for PNH and discuss important transplant-related issues.
  
  
  RESULTS
  Both patients are alive and are doing well over 12 and over 4 months following BMT. Regeneration is complete with full 100% donor chimerism and the eradication of PNH clone.
  
  
  CONCLUSIONS
  MUD BMT is an effective treatment for PNH. Treosulfan, Fludarabine and Thymoglobulin treatment can be safely and effectively used for conditioning in PNH.
authors.affiliation: Department of Hematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland. mir.markiewicz@wp.pl
authors.forename: Mirosław
authors.initials: M
authors.lastname: Markiewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Wojciechowska
authors.forename: Iwona
authors.initials: I
authors.lastname: Wylezoł
authors.forename: Sebastian
authors.initials: S
authors.lastname: Giebel
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Woźniczka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wojnar
authors.forename: Ewa
authors.initials: E
authors.lastname: Mendek-Czajkowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Hołowiecki
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D011044:Poland; D019172:Transplantation Conditioning; D016896:Treatment Outcome