Modulation of leptin, insulin, and growth hormone in obese pony mares under chronic nutritional restriction and supplementation with ractopamine hydrochloride.
Horses fed beyond their nutritional requirement and that are physically inactive will develop obesity, which is often accompanied by insulin resistance and heightened risk of laminitis. The use of pharmacologic agents in combination with nutritional restriction may promote weight loss in obese horses unable to exercise because of laminitic pain. This study shows that reducing feed intake of brome grass hay to 75% of ad libitum intake in obese pony mares reduces body weight without induced exercise. Additional supplementation of ractopamine hydrochloride for 6 weeks resulted in a tendency for increased weight loss. Subsequent modulation of obesity-associated hormones, leptin and insulin, as a result of caloric restriction was observed.
Buff
Preston R
PR
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Johnson
Philip J
PJ
Wiedmeyer
Charles E
CE
Ganjam
Venkataseshu K
VK
Messer Iv
Nat T
NT
Keisler
Duane H
DH
D000818:Animals; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004334:Drug Administration Schedule; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006133:Growth Substances / Q000008:administration & dosage*; D006734:Horse Diseases / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy*; D006736:Horses; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy / Q000662:veterinary*; D010627:Phenethylamines / Q000008:administration & dosage*; D016896:Treatment Outcome
D006133:Growth Substances; D007328:Insulin; D020738:Leptin; D010627:Phenethylamines; C060897:ractopamine; D013006:Growth Hormone