Acinar cell ultrastructure after taurine treatment in rat acute necrotizing pancreatitis.
OBJECTIVE
To evaluate the organelle-based changes in acinar cells in experimental acute necrotizing pancreatitis (ANP) after taurine treatment and the association of electron microscopic findings with histopathological changes and oxidative stress markers.


METHODS
The study was performed in February 2005 at Gulhane School of Medicine and Hecettepe University, Turkey. Forty-five rats were divided into 3 groups. Acute necrotizing pancreatitis was induced in groups II and III. Groups I and II were treated with saline and Group III with taurine 1000 mg/kg/day, i.p, for 48 hours. Histopathological and ultrastructural examinations were determined using one-way analysis of variance and Kruskal-Wallis tests.


RESULTS
Histopathologic findings improved significantly after taurine treatment. Degree of injury in rough and smooth endoplasmic reticulums, Golgi apparatus, mitochondria and nucleus of acinar cells also decreased with taurine in correlation with biochemical and histological results.


CONCLUSIONS
Taurine improves acinar cell organelle structure, and ultrastructural recovery in ANP reflects histological improvement.
Ates
Yuksel
Y
Department of Internal Medicine, Gulhane School of Medicine, Baskent University, Ankara, Turkey.
Mas
Mehmet R
MR
Mas
Nuket
N
Tasci
Ilker
I
Comert
Bilgin
B
Isik
Ahmet T
AT
Yener
Nuran
N
D000818:Animals; D015415:Biomarkers / Q000097:blood; D008297:Male; D015388:Organelles / Q000648:ultrastructure*; D018384:Oxidative Stress / Q000502:physiology; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000627:therapeutic use*
D015415:Biomarkers; D013654:Taurine