Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease.
Animal and epidemiologic studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of Parkinson disease (PD). The authors studied 1,258 PD cases and 6,638 controls from the General Practice Research Database. The odds ratios (95% CI) for ever vs never use were 0.93 (0.80 to 1.08) for nonaspirin NSAIDs, 1.29 (1.05 to 1.58) for aspirin, and 1.16 (1.00 to 1.35) for acetaminophen. Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men.
Hernán
Miguel A
MA
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. miguel_hernan@post.harvard.edu
Logroscino
Giancarlo
G
García Rodríguez
Luis A
LA
D000082:Acetaminophen / Q000009:adverse effects; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects; D016022:Case-Control Studies; D015331:Cohort Studies; D016208:Databases, Factual; D005194:Family Practice; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D012727:Sex Characteristics; D014202:Tremor; D006113:United Kingdom / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000978:Antiparkinson Agents; D000082:Acetaminophen; D001241:Aspirin