title: Fatty acids profile and antiinflammatory activity of Nonea setosa R. et S.
abstract: In order to verify the antiinflammatory properties of Nonea setosa R. et S. (Fam. Boraginaceae) and to identify the relevant active principles, aerial parts of this plant were extracted with increasing polarity solvents. The antiinflammatory activity was investigated by a bioassay-oriented fractionation using the inhibition of the croton oil-induced ear oedema in mice as an experimental model of inflammation. GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Perugia, Italy. curmax@unipg.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Alessandro
authors.initials: A
authors.lastname: Menghini
authors.forename: Gianmario
authors.initials: G
authors.lastname: Altinier
authors.forename: Aurelia
authors.initials: A
authors.lastname: Tubaro
authors.forename: Luigi
authors.initials: L
authors.lastname: Menghini
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D028082:Boraginaceae; D003436:Croton Oil; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005227:Fatty Acids / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D010936:Plant Extracts; D003436:Croton Oil