title: An MRI study of minor physical anomalies in autism.
abstract: The objective of this investigation was to examine the existence of minor physical anomalies (MPA) in autism. The interorbital and interlens distances were measured on MRI scans obtained from a sample of 40 non-mentally retarded individuals with autism and 41 healthy controls. No differences were observed between the two groups on any measurements. However, when the analysis was conducted using a split median procedure, individuals with autism and either low FSIQ, PIQ, or VIQ had shorter interorbital distances when compared to controls. Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning.
authors.affiliation: Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. hardanay@stanford.edu
authors.forename: Antonio Y
authors.initials: AY
authors.lastname: Hardan
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: Sucheta
authors.initials: S
authors.lastname: Sreedhar
authors.forename: Mahduri
authors.initials: M
authors.lastname: Vemulapalli
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Minshew
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000503:physiopathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D006801:Humans; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012016:Reference Values; D013060:Speech