Arteriolar remodeling in essential hypertension: are connective tissue growth factor and transforming growth factor involved?
Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-beta and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expression. The discordant effects of two well-accepted treatments for hypertension underline the need for further studies on therapy-induced changes in arteriolar remodeling.
Rodriguez-Iturbe
B
B
Hospital Universitario and Universidad del Zulia, Maracaibo, Venezuela. bernardori@telcel.net.ve
D017311:Amlodipine / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D001160:Arterioles / Q000503:physiopathology*; D055513:Connective Tissue Growth Factor; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D017874:Immediate-Early Proteins / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D019808:Losartan / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000502:physiology*
D000959:Antihypertensive Agents; C526317:CCN2 protein, human; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D055513:Connective Tissue Growth Factor; D017311:Amlodipine; D019808:Losartan