ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.
Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.
Thabet
Farah
F
Department of Pediatrics, Hospital Farhat Hached, Sousse, Tunisia. thabetfarah@yahoo.fr
Sghiri
Rim
R
Tabarki
Brahim
B
Ghedira
Ibtissem
I
Yacoub
Moncef
M
Essoussi
Ahmed Sahloul
AS
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D002648:Child; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000276:immunology; D013889:Thiouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D013889:Thiouracil; C019269:benzylthiouracil