title: [The first newborn with congenital rubella syndrome during the rubella epidemic in The Netherlands in 2004/'05].
abstract: A newborn male was diagnosed with congenital rubella syndrome. His 31-year-old mother had had erythematous exanthema during a period of amenorrhea lasting 7 weeks; she was not vaccinated and had never had a rubella infection. The infection was confirmed serologically. The mother gave birth to an icteric, microcephalic, dysmature neonate with hepatosplenomegaly and exanthema with multiple, small purple-red spots. Ultrasound cardiography revealed a persistently open arterial duct and a small defect of the ventricular septum. Radiological evaluation of the long bones showed the characteristic longitudinal lucent strands ('celery stalk appearance'). Ultrasound of the cerebrum showed diffuse widespread calcifications in the white matter and basal ganglia, striatal vasculopathy and diffuse parenchymal disorders. Psychomotor development was impaired. The patient was completely deaf in the left ear and had severely poor hearing in the right ear. After the introduction of the rubella vaccine in the Netherlands in 1974 a substantial decrease was seen in the incidence of rubella infections as well as congenital rubella syndrome. An epidemic of rubella infections has been present within the non-vaccinated population since September 2004. Recognition of the clinical symptoms and confirmation of the clinical suspicion with proper viral diagnostic methods are needed to control the current epidemic and to prevent secundary spread. Infants born with congenital rubella syndrome remain infectious to non-vaccinated individuals for a prolonged period of time; the virus is excreted in the urine and faeces. Long-term medical follow-up is necessary because the congenital rubella infection can cause abnormalities after the neonatal period.
authors.affiliation: Universitair Medisch Centrum St Radboud, 6500 HB Nijmegen. a.c.demol@cukz.umcn.nl
authors.forename: A C
authors.initials: AC
authors.lastname: de Mol
authors.forename: S
authors.initials: S
authors.lastname: Vrancken
authors.forename: A J
authors.initials: AJ
authors.lastname: Eggink
authors.forename: F M
authors.initials: FM
authors.lastname: Verduyn Lunel
authors.forename: A
authors.initials: A
authors.lastname: Warris
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology*; D012409:Rubella / Q000175:diagnosis / Q000453:epidemiology*; D012410:Rubella Syndrome, Congenital / Q000175:diagnosis*; D012411:Rubella Vaccine / Q000008:administration & dosage
chemical_list: D012411:Rubella Vaccine