Recyclable polymeric pi-acid catalyst effective on Mannich-type reaction in water.
Polymer-supported dicyanoketene acetal (poly-DCKA-1), synthesized by copolymerization of a DCKA bearing a 4-vinylbenzyl group with ethyleneglycol dimethacrylate, was found to be an excellent recyclable catalyst for the three-component Mannich-type reaction of aldehydes, aromatic amines, and TMS enolate of ethyl isobutyrate in water as the sole solvent.
Masaki
Yukio
Y
Gifu Pharmaceutical University, Japan. masakiy@ccmfs.meijo-u.ac.jp
Yamazaki
Kouichi
K
Kawai
Hyouei
H
Yamada
Tomoyasu
T
Itoh
Akichika
A
Arai
Yoshitsugu
Y
Furukawa
Hiroshi
H
D000080:Acetals / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002087:Butyrates / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic; D058610:Isobutyrates; D008352:Mannich Bases / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry*; D055601:Organic Chemistry Phenomena; D011108:Polymers / Q000737:chemistry*; D020058:Styrene / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D000080:Acetals; D000447:Aldehydes; D000588:Amines; D002087:Butyrates; D058610:Isobutyrates; D008352:Mannich Bases; D008689:Methacrylates; D009570:Nitriles; D011108:Polymers; C511101:poly-dicyanoketene acetal; D014867:Water; D020058:Styrene; C004919:ethylene dimethacrylate; C020380:isobutyric acid