title: Kinetic resolution of diols and pyridyl alcohols by Cu(II)(borabox)-catalyzed acylation.
abstract: [reaction: see text] Boron-bridged bisoxazoline (borabox) ligands have been used in the copper(II)-catalyzed benzoylation of pyridyl alcohols and 1,2-diols. Efficient kinetic resolution of 1,2-diols was achieved using both borabox and bisoxazoline (box) ligands. Borabox ligands induced high selectivities in the benzoylation of suitable pyridyl alcohols, where they outperformed bisoxazolines. In addition, highly enantioselective Cu(II)(borabox)-catalyzed benzoylation has been used for the synthesis of both enantiomers of a pyridyl alcohol.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
authors.forename: Clément
authors.initials: C
authors.lastname: Mazet
authors.forename: Stephen
authors.initials: S
authors.lastname: Roseblade
authors.forename: Valentin
authors.initials: V
authors.lastname: Köhler
authors.forename: Andreas
authors.initials: A
authors.lastname: Pfaltz