title: [Gastrointestinal stromal tumors. Actual diagnosis and treatment].
abstract: Gastrointestinal stromal tumors (GISTs) are currently defined as c-Kit-positive mesenchymal tumors with specific histological characteristics. CD117 (c-Kit protein) is a growth factor receptor with tyrosine kinase activity and product of the protooncogene c-Kit. The most frequent sign is gastrointestinal haemorrhage, which occurs in approximately one third of patients. The evaluations which are necessary for diagnosis include clinical examination, immunohistochemistry analysis, endoscopic examination, X-ray, abdominal CT scan, ultrasound, MRI, exploratory surgery, biopsy or fine-needle aspiration of the tumor. Current data suggest a major role of a new tyrosine kinase inhibitor, imatinib mesylate (Glivec), for patients with metastatic or advanced disease. Surgical resection is the treatment of choice and offers the only chance for cure.
authors.affiliation: Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Institutul de Gastroenterologie si Hepatologie Iaşi, Facultatea de Medicină.
authors.forename: Carmen Rodica
authors.initials: CR
authors.lastname: Anton
authors.forename: Gabriela
authors.initials: G
authors.lastname: Balan
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D013505:Digestive System Surgical Procedures; D016099:Endoscopy, Gastrointestinal; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D010879:Piperazines / Q000627:therapeutic use; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D011743:Pyrimidines / Q000627:therapeutic use; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit