title: An interactive tool for visualization of relationships between gene expression profiles.
abstract: BACKGROUND
  Application of phenetic methods to gene expression analysis proved to be a successful approach. Visualizing the results in a 3-dimentional space may further enhance these techniques.
  
  
  RESULTS
  We designed and built TreeBuilder3D, an interactive viewer for visualizing the hierarchical relationships between expression profiles such as SAGE libraries or microarrays. The program allows loading expression data as plain text files and visualizing the relative differences of the analyzed datasets in 3-dimensional space using various distance metrics.
  
  
  CONCLUSIONS
  TreeBuilder3D provides a simple interface and has a small size. Written in Java, TreeBuilder3D is a platform-independent, open source application, which may be useful in analysis of large-scale gene expression data.
authors.affiliation: Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC V5Z 4S6, Canada. pruzanov@bcgsc.ca
authors.forename: Peter
authors.initials: P
authors.lastname: Ruzanov
authors.forename: Steven J M
authors.initials: SJ
authors.lastname: Jones
mesh_terms: D000465:Algorithms; D000818:Animals; D003196:Computer Graphics; D003198:Computer Simulation; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015398:Signal Transduction / Q000502:physiology; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors