T-cell gamma/delta hepatosplenic lymphoma - prolonged remission induced by aggressive first line treatment.
T-cell gamma/delta hepatosplenic lymphoma is a primary extranodal lymphoma, distinct from other T/LGL lymphomas. The clinical course is aggressive, and despite use of the multiagent chemotherapy and young age of the patients, the median survival is less than 1 year. Curability of this disease is still uncertain. We reported a case of the successful intensive treatment with splenectomy, chemotherapy a first line autologous stem cell transplant. High intensity cytarabine- platinum containing regimen (EDHAP) may overcome primary resistance to conventional alkylating agents.
Procházka
Vít
V
Department of Hemato-oncology, Teaching Hospital, Olomouc, Czech Republic.
Papajík
Tomás
T
Jarosová
Marie
M
Pikalová
Zuzana
Z
Indrák
Karel
K
Tichý
Martin
M
Kucerová
Ladislava
L
Fakan
Frantisek
F
Bílý
Milan
M
Starostka
David
D
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012074:Remission Induction; D013160:Splenic Neoplasms / Q000188:drug therapy* / Q000473:pathology
D016692:Receptors, Antigen, T-Cell, gamma-delta