title: Effect of a new ultrashort betalytic agent on aconitine-induced arrhythmia.
abstract: The anti-arrhythmic effect was tested on the model of aconitine-induced arrhythmia. The experiment was performed in vivo with 31 male Wistar laboratory rats. Group A was first administered aconitine and, after the onset of the first sinus rhythm disorders, the 44Bu compound was administered. Group B was first administered the 44Bu compound and only after that the aconitine. The control group was administered aconitine and saline as a replacement of the tested compound. In group A, there was a decrease in the ventricular fibrillation occurrence from 100 % to 8 % (p < 0.001) after the administration of the 44Bu compound. In the B group, the onsets of all monitored arrhythmia types were delayed by an average of 15.6 min. Ventricular rhythm occurrence was decreased from 100 to 20 %, as well as ventricular fibrillations, from 100 to 0 % (p < 0.001).
authors.affiliation: Department of Human Pharmacology and Toxicology, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic. bartosoval@vfu.cz
authors.forename: Ladislava
authors.initials: L
authors.lastname: Bartosová
authors.forename: Filip
authors.initials: F
authors.lastname: Novák
authors.forename: Marek
authors.initials: M
authors.lastname: Frydrych
authors.forename: Tomás
authors.initials: T
authors.lastname: Parák
authors.forename: Radka
authors.initials: R
authors.lastname: Opatrilová
authors.forename: Vít
authors.initials: V
authors.lastname: Brunclík
authors.forename: Jana
authors.initials: J
authors.lastname: Kolevská
authors.forename: Elnaggar
authors.initials: E
authors.lastname: El Moataz
authors.forename: Jirí
authors.initials: J
authors.lastname: Necas
mesh_terms: D000157:Aconitine / Q000633:toxicity*; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001565:Benzoates / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001565:Benzoates; D000157:Aconitine