title: [Creatine as a metabolic controller of skeletal muscles structure and function in strength exercises in humans. The cellular mechanisms].
abstract: The effects of creatine oral supplementation combined with a 10-week resistive training of morphometric, contractile and molecular characteristics of human vast lateral muscle fibers were studied. 2 groups consisting of 9 young healthy men each were involved in resistive training of knee extensors for 10 weeks. Volunteers of the first group received per os 20 g of creatine for the 1st week of training and 5 g for the rest of the experimental training period. We found a significant increase of slow and fast-twitch fiber size in both trained groups and a significant increase of Ca-sensitivity of skinned single fiber contractility in creatine-supplemented group. The serum creatine phosphokinase activity in blood samples taken 24 hours after exercise session increased in all stages of the experimental training in both groups. At the same time, the adaptive decrease of the after-exercise CK concentration was observed in the placebo but not in the creatine-supplemented group. The altered integrity of the subsarcolemmal dystrophin layer was revealed in both groups after training.
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: K S
authors.initials: KS
authors.lastname: Litvinova
authors.forename: N M
authors.initials: NM
authors.lastname: Gasnikova
authors.forename: P P
authors.initials: PP
authors.lastname: Tarakin
authors.forename: I N
authors.initials: IN
authors.lastname: Chistiakov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Lemesheva
authors.forename: I M
authors.initials: IM
authors.lastname: Vikhliantsev
authors.forename: Z A
authors.initials: ZA
authors.lastname: Podlubnaia
authors.forename: T L
authors.initials: TL
authors.lastname: Nemirovskaia
authors.forename: V P
authors.initials: VP
authors.lastname: Khotchenkov
authors.forename: T N
authors.initials: TN
authors.lastname: Stekhanova
authors.forename: M A
authors.initials: MA
authors.lastname: Kovaleva
authors.forename: D V
authors.initials: DV
authors.lastname: Popov
authors.forename: A I
authors.initials: AI
authors.lastname: Netreba
authors.forename: O L
authors.initials: OL
authors.lastname: Vinogradova
mesh_terms: D000328:Adult; D003401:Creatine / Q000008:administration & dosage*; D016189:Dystrophin / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000166:cytology / Q000502:physiology*; D018657:Muscle Fibers, Slow-Twitch / Q000166:cytology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D012508:Sarcolemma / Q000502:physiology
chemical_list: D016189:Dystrophin; D003401:Creatine