Antihypertensive pharmacobezoar.
Most antihypertensive drugs have known side effects that are elicited by the careful clinician taking care of hypertensive patients. However, many antihypertensive medications utilize drug delivery systems that prolong the duration of blood pressure reduction. The gastrointestinal therapeutic system that is used with nifedipine, isradipine, and verapamil has a unique side effect. Obstruction may occur at the site of a previous surgical repair (pyloric stenosis or gastroplasty) or stenosis of the esophagus, small intestine, or colon. The same delivery system is used with methylphenidate, oxybutynin, glipizide, and doxazosin. Although this complication is rare, physicians who prescribe and care for hypertensive patients should recognize this potential problem.
Prisant
L Michael
LM
Department of Hypertension & Clinical Pharmacology, Medical College of Georgia, 1470 Harper Street, Augusta, GA 30912, USA. mprisant@mcg.edu
Spaulding
Vernon C
VC
D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001630:Bezoars / Q000209:etiology*; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006801:Humans; D017275:Isradipine / Q000008:administration & dosage / Q000009:adverse effects; D009543:Nifedipine / Q000008:administration & dosage; D011183:Postoperative Complications / Q000209:etiology; D013607:Tablets; D014700:Verapamil / Q000008:administration & dosage / Q000009:adverse effects
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D013607:Tablets; D014700:Verapamil; D009543:Nifedipine; D017275:Isradipine