Insight into management of dementias from neuroimaging.
Structural and functional neuroimagings are the most powerful tools for differential diagnosis and early diagnosis of dementia. Besides clinical use, they also contribute to neuroscience and to testing efficacy as surrogate measures in clinical trial. This paper, focusing on two different models beyond the therapeutic nihilism, discusses the roles of neuroimaging in relation to treatment of dementias; 1) treatable "incurable dementia" - Alzheimer's disease (AD) and 2) untreated "curable dementia" - idiopathic normal pressure hydrocephalus (INPH).
Mori
Etsuro
E
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School ofMedicine, Sendai, Japan.
D000544:Alzheimer Disease / Q000473:pathology* / Q000628:therapy; D001057:Apolipoproteins E / Q000235:genetics; D001284:Atrophy; D005838:Genotype; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging
D001057:Apolipoproteins E