Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat.
The effect of intracerebroventricular infusion of galanin and/or the galanin antagonist M35 was studied in the forced swim test. Animals were pre-exposed to water for 15 min 24 h prior to test. Immobility and climbing were assessed during the second, 5 min exposure to water. Rats receiving a single infusion of galanin (3 nmol) displayed a significant increase of immobility. This effect was blocked by co-administration of M35 (1 nmol). M35 alone (1 nmol) produced a significant decrease of immobility. The results further support the hypothesis that galanin may play a role in mood disorders, and that galanin antagonists may represent new candidates for antidepressant treatment.
Kuteeva
Eugenia
E
Department of Neuroscience, Karolinska Institutet, Retzius väg. 8, S-171 77 Stockholm, Sweden.
Wardi
Tara
T
Hökfelt
Tomas
T
Ogren
Sven Ove
SO
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001920:Bradykinin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D019004:Galanin / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D046353:Immobility Response, Tonic / Q000187:drug effects; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming
D004338:Drug Combinations; D010446:Peptide Fragments; C074069:galanin-(1-13)-bradykinin-(2-9)-amide; D019004:Galanin; D001920:Bradykinin