title: [The influence of intermediate physical training on some non-enzyme antioxidants of oxidative stress, in moderate hypertension].
abstract: A group of patients with moderate hypertension (149-150/90-99 mm Hg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some biochemical markers, non-enzyme antioxidants, glutathione (GSH), total -SH groups (G-STH), nonprotein -SH groups (G-SHNP), their G-SHT/G-SHNP ratio, uric acid, malondialdehyde (MDA) and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the HTA patients, with initial (Vi) decreasing values of GSH and uric acid, and with higher values of MDA. After the 3 months (Vf) of physical training, the oxidative stress improved, with increasing GSH, uric acid and decreasing MDA, compared to normal subjects. The initial values of G-SHT, G-SHNP and their ratio, increased, but decreased after 3 months, with an inverse aspect to GSH. The clinical study proved that after 3 months of physical exercise, there wasn't any increased oxidative stress at the HTA patients; however, the oxidative stress is present, proved by the values of MDA, significantly higher compared to the normal subjects.
authors.affiliation: Universitatea de Medicină şi Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Disciplina de Biochimie.
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Jerca
authors.forename: Silvia
authors.initials: S
authors.lastname: Chiriac
authors.forename: Oltiţa Putină
authors.initials: OP
authors.lastname: Jerca
authors.forename: Corina Dima
authors.initials: CD
authors.lastname: Cozma
authors.forename: Irina
authors.initials: I
authors.lastname: Constantinescu
authors.forename: St
authors.initials: S
authors.lastname: Chiriac
authors.forename: Nastasia
authors.initials: N
authors.lastname: Gheorghiţă
authors.forename: G I
authors.initials: GI
authors.lastname: Pandele
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015444:Exercise; D005978:Glutathione / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014527:Uric Acid; D008315:Malondialdehyde; D005978:Glutathione