Using of electrochemical methods for studying of metallothionein content in the human blood serum of a patient poisoned by lead and treated by platinum.
Metallothioneins belong to the group of intracellular, high molecular and cysteine-rich proteins whose content increase with increasing concentration of a heavy metal. Here we applied the adsorptive transfer stripping differential pulse voltammetry Brdicka reaction for the determination of metallothionein in human blood serum of patient poisoned by lead and/or treated by platinum. The increased metallothionein concentrations in both cases were observed.
Petrlová
Jitka
J
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University of Agriculture and Forestry, Zemedelská 1, Brno, CZ-613 00, Czech Republic. kizek@sci.muni.cz.
Blastík
Ondrej
O
Průsa
Richard
R
Kukacka
Jirí
J
Potĕsil
David
D
Mikelová
Radka
R
Adam
Vojtĕch
V
Zehnálek
Josef
J
Kizek
René
R
D002648:Child; D004563:Electrochemistry / Q000379:methods; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000097:blood*; D008668:Metallothionein / Q000097:blood*; D017671:Platinum Compounds / Q000627:therapeutic use*
D017671:Platinum Compounds; D008668:Metallothionein