[Chemical basis of the effects of Tamm-Horsfall protein on the formation of calcium oxalate stones].
Tamm-Horsfall (TH) protein is the most abundant protein in human urine. It plays dual roles in the formation of calcium oxalate stones depending on its structure, concentration and urine properties. In this paper, the chemical basis of the effects of TH protein on the formation of calcium oxalate stones was systematically discussed in view of the concentration of TH protein, the urinary pH, ionic strength, metallic ions, the cooperative effect of citrate and TH protein, and the effect on the adhesion of calcium oxalate crystals to the renal cell membrane. The differentiation between TH protein and its analog was also comparatively discussed.
Deng
Fang
F
Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.
Ouyang
Jian-Ming
JM
D002129:Calcium Oxalate / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D009088:Mucoproteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D014545:Urinary Calculi / Q000209:etiology* / Q000378:metabolism; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D002129:Calcium Oxalate