New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.
[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10,000 TON) are observed.
Guram
Anil S
AS
Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. aguram@amgen.com
King
Anthony O
AO
Allen
John G
JG
Wang
Xianghong
X
Schenkel
Laurie B
LB
Chan
Johann
J
Bunel
Emilio E
EE
Faul
Margaret M
MM
Larsen
Robert D
RD
Martinelli
Michael J
MJ
Reider
Paul J
PJ