Manipulating cellular transport and immune responses: dynamic interactions between intracellular Salmonella enterica and its host cells.
Intracellular survival and replication within eukaryotic host cells is of central importance for the pathogenesis of infections caused by Salmonella enterica. Intracellular Salmonella translocates a set of effector proteins by means of a type III secretion system (T3SS) encoded by Salmonella pathogenicity island 2 (SPI2) that manipulates normal host-cell functions. Intracellular survival and replication is linked to the function of the SPI2-T3SS, but recent observations show that many additional cellular functions are targeted by this virulence system. In this review, we focus on the recent observations on the interference of intracellular Salmonella with functions of the innate and adaptive immune system and the modification of endocytic and exocytic cellular transport. The common molecular basis of the different SPI2-dependent phenotypes could be the interference with cellular transport along microtubules.
Abrahams
Garth L
GL
Institut für Klinische Mikrobiologie, Immunologie und Hygiene, FAU Erlangen-Nürnberg, Erlangen, Germany.
Hensel
Michael
M
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000382:microbiology; D044404:Genomic Islands; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D021381:Protein Transport; D017382:Reactive Oxygen Species / Q000378:metabolism; D012480:Salmonella Infections / Q000276:immunology / Q000382:microbiology; D019779:Salmonella enterica / Q000502:physiology*
D001426:Bacterial Proteins; D008565:Membrane Proteins; D017382:Reactive Oxygen Species; C440638:SPI-2 protein, Salmonella