Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA.
Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. The interaction modes of quercetins with monomeric and dimeric G-quadruplexes were studied by absorption, fluorescence, CD, and (1)H NMR spectroscopies. The ligands were found to be stacked with terminal tetrads of monomeric G-quadruplexes by intercalation and bound to dimeric G-quadruplexes by groove binding.
Sun
Hongxia
H
Beijing University of Chemical Technology, Beijing 100029, China.
Tang
Yalin
Y
Xiang
Junfeng
J
Xu
Guangzhi
G
Zhang
Yazhou
Y
Zhang
Hong
H
Xu
Lianghua
L
D001665:Binding Sites; D002942:Circular Dichroism / Q000379:methods; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D054856:G-Quadruplexes; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry* / Q000494:pharmacology*; D012015:Reference Standards; D013050:Spectrometry, Fluorescence / Q000379:methods; D013329:Structure-Activity Relationship
D008024:Ligands; D004247:DNA; D011794:Quercetin