title: [Clinical study on preventive effect of fuzheng quxie granule on respiratory viral infection].
abstract: OBJECTIVE
  To evaluate the effect of Fuzheng Quxie granule (FQG) on immune cells and cytokines of populations susceptible to respiratory viral infection.
  
  
  METHODS
  One thousand four hundred and two subjects selected from 25 hospitals in Shanghai between May and June in 2003, were divided into the FQG group treated with FQG and the control group treated with placebo. Serum levels of interleukin 2 (IL-2), interleukin 4 (IL-4), gamma-interferon (gamma-IFN), blood lymphocyte subsets (CD3+ , CD4+, CD8+), B-cell count and natural killer cell (NK) percent ratio were measured in 130 of the FQG group and 120 of the control group before treatment, by the end of the 2nd week and two weeks after treatment.
  
  
  RESULTS
  By the end of the 2nd week of treatment, as compared with before treatment, the levels of IL-2, gamma-IFN, and NK percent in the FQG group increased significantly (P < 0.05), while IL-4 and CD3+, CD4+, CD8+ and B-cell count were unchanged. Besides, levels of Th1/Th2 ratio markedly increased at the end of the 2nd week and two weeks after treatment, in comparing with that before treatment and in the control group (P<0.05).
  
  
  CONCLUSIONS
  FQG could improve immune function of population susceptible to respiratory viral infection certain extent.
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine on Pulmonary and Atopic Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai (200040). jcdong2004@hotmail.com
authors.forename: Jing-Cheng
authors.initials: JC
authors.lastname: Dong
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Gong
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Liu
authors.forename: Jinyu
authors.initials: J
authors.lastname: Xie
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Dong
authors.forename: Fudong
authors.initials: F
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007371:Interferon-gamma; D007376:Interleukin-2 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D014777:Virus Diseases / Q000517:prevention & control*
chemical_list: D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma