Doing the unexpected: proteins involved in hydrogen peroxide perception.
A look back at the early literature on reactive oxygen species (ROS) gives the impression that these small inorganic molecules had a singular defined role, that of host defence in mammalian systems. However, it is now known that their roles also include a major part in cell signalling, in a broad range of organisms from mammals to plants. Similarly, a look back at papers on the proteins now thought to be involved in the perception of hydrogen peroxide (H(2)O(2)) will show that they too had defined functions assigned to them, completely independent to H(2)O(2) signalling. These proteins have disparate roles, in ethylene perception or even major metabolic pathways such as glycolysis. However, the chemistry of H(2)O(2) sensing dictates that the proteins have a commonality, with active thiol groups being potential ROS targets. The challenge now is to determine the full range of proteins which may partake in the role of H(2)O(2) perception, and to determine the mechanisms by which the signal is transmitted to the next players in the signal transduction pathways.
Hancock
John
J
Centre for Research in Plant Science, Genomics Research Institute, University of the West of England, Bristol, Coldharbour Lane, Bristol BS16 1QY, UK. john.hancock@uwe.ac.uk
Desikan
Radhika
R
Harrison
Judith
J
Bright
Jo
J
Hooley
Richard
R
Neill
Steven
S
D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000502:physiology; D000071677:Histidine Kinase; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology; D010084:Oxidation-Reduction; D010940:Plant Proteins / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D010940:Plant Proteins; D013438:Sulfhydryl Compounds; D014157:Transcription Factors; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D011494:Protein Kinases; D000071677:Histidine Kinase