title: Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes.
abstract: Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.
authors.affiliation: Department of Physiology & Biophysics, UCDHSC at Fitzsimons, Aurora, Colorado 80045, USA.
authors.forename: Alicia E
authors.initials: AE
authors.lastname: Novak
authors.forename: Alison D
authors.initials: AD
authors.lastname: Taylor
authors.forename: Ricardo H
authors.initials: RH
authors.lastname: Pineda
authors.forename: Erika L
authors.initials: EL
authors.lastname: Lasda
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Wright
authors.forename: Angeles B
authors.initials: AB
authors.lastname: Ribera
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015640:Ion Channel Gating; D007814:Larva / Q000378:metabolism; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D021122:Protein Subunits; D015222:Sodium Channels; D029961:Zebrafish Proteins