title: Dynamic functional tuning of nonlinear cortical networks.
abstract: The mammalian neocortex is a highly complex and nonlinear dynamic system. One of its most prominent features is an omnipresent spontaneous neuronal activity. Here the possible functional role of this global background for cognitive flexibility is studied in a prototypic mean-field model area. It is demonstrated that the level of global background current efficiently controls the stimulus-response threshold and the stability and properties of short-term memory states. Moreover, it can dynamically gate arbitrary cortical subnetworks, when applied to parts of the area as a weak bias signal. These results suggest a central functional role of the level of background activation: the dynamic functional tuning of neocortical circuits.
authors.affiliation: Siemens AG, Corporate Technology, Information & Communications, D-81730 Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Stetter
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D019579:Neocortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics; D009435:Synaptic Transmission / Q000502:physiology*