Downregulation of selected cytokines in amebiasis.
A 220-kDa E. histolytica lectin is capable of downregulating some inflammatory cytokines (IL-5, IL-6, INF-gamma and TNF-alpha) and thus of inducing an overall anti-inflammatory Th-phenotype in leucocytes of selected, perhaps constitutionally predisposed, individuals irrespective of their HLA-DR3 profile (i.e., in this study patients long recovered from amebic abscess of the liver). This probably inhibited cytokine response pattern could increase the risk for developing amebic abscess of the liver in the course of invasive intestinal amebiasis.
Bekker-Mendez
Vilma Carolina
VC
Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, CMN-Siglo XXI, IMSS, México, DF, México.
Pérez-Castillo
Viola Leticia
VL
Rico-Rosillo
María Guadalupe
MG
Pérez-Rodríguez
Martha
M
Arellano-Blanco
Jorge
J
Kretschmer-Schmid
Roberto Rodolfo
RR
Talamás-Rohana
Patricia
P
D000562:Amebiasis / Q000378:metabolism* / Q000469:parasitology; D000656:Amoeba / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D007962:Leukocytes / Q000378:metabolism
D016207:Cytokines