Immunotherapy of neuroblastoma: present, past and future.
Neuroblastoma is a neuroectodermal tumor of childhood with poor prognosis and low survival in patients with advanced-stage disease who respond to conventional therapies but unfortunately, often present relapse. Therefore, the search for novel therapeutic strategies is warranted and represents the objective of many investigators. Among the new, innovative approaches, immunotherapy has attracted much interest. However, until recently, little information was available about the immunogenicity of human neuroblastoma.
Raffaghello
Lizzia
L
Laboratory of Oncology, G Gaslini Institute, Largo Gerolamo Gaslini 5, 16147 Genova, Italy. lizziaraffaghello@ospedale-gaslini.ge.it
Pistoia
Vito
V
D000818:Animals; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000276:immunology* / Q000628:therapy*; D005544:Forecasting; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends*; D009447:Neuroblastoma / Q000235:genetics / Q000276:immunology* / Q000628:therapy*