[Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China].
OBJECTIVE
To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population.


METHODS
Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations.


RESULTS
Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively.


CONCLUSIONS
The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations.
Wang
Qing-hua
QH
Department of Urology, Fuzhou General Hospital, Nanjing Command of PLA, Fuzhou, Fujian, 350025 P.R.China.
Chen
Wei-zhen
WZ
Tan
Jian-ming
JM
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D005843:Geography; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D011110:Polymorphism, Genetic; D044382:Population Groups
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains