title: Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions.
abstract: The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, 35 Convent Drive, Bethesda, MD 20892, USA.
authors.forename: O
authors.initials: O
authors.lastname: Adighibe
authors.forename: K
authors.initials: K
authors.lastname: Micklem
authors.forename: L
authors.initials: L
authors.lastname: Campo
authors.forename: M
authors.initials: M
authors.lastname: Ferguson
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: R
authors.initials: R
authors.lastname: Pozos
authors.forename: K
authors.initials: K
authors.lastname: Gatter
authors.forename: F
authors.initials: F
authors.lastname: Pezzella
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D021621:Imaging, Three-Dimensional; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D009389:Neovascularization, Pathologic; D013194:Staining and Labeling
chemical_list: D018952:Antigens, CD34; D007633:Keratins