title: Functional protein arrays to facilitate drug discovery and development.
abstract: Protein microarrays are miniaturized formats for studying proteins. This technology is empowering investigators with the ability to profile numerous types of interactions to progress basic science research and to advance drug discovery and development. Protein microarrays are poised to make significant contributions to our understanding of biology and disease because: (i) both covalent and non-covalent interactions can be reconstituted on solid-state supports; and (ii) a wealth of knowledge can be generated rapidly from such simple experiments. This feature focuses on applications of protein microarrays that have tremendous potential for addressing bottlenecks in disease-focused discovery efforts.
authors.affiliation: Invitrogen Corp, Research and Development, Protein Array Center, Branford, CT 06405, USA. Gregory.michaud@invitrogen.com
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Michaud
authors.forename: Michael L
authors.initials: ML
authors.lastname: Samuels
authors.forename: Barry
authors.initials: B
authors.lastname: Schweitzer
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D004345:Drug Industry / Q000379:methods*; D006801:Humans; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D011494:Protein Kinases / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D015415:Biomarkers; D011494:Protein Kinases