title: Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.
abstract: Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.
authors.affiliation: Department of Pathobiology, University of Washington, Box 357238, Seattle, WA 98195, USA. lacamp@u.washington.edu
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Campbell
authors.forename: Amy
authors.initials: A
authors.lastname: Lee
authors.forename: Cho-chou
authors.initials: CC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D002690:Chlamydia Infections / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D008171:Lung Diseases / Q000517:prevention & control*; D051379:Mice; D009844:Oligosaccharides / Q000378:metabolism*; D043524:Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / Q000494:pharmacology; D011134:Polysaccharides / Q000502:physiology*
chemical_list: D009844:Oligosaccharides; D011134:Polysaccharides; D043524:Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase