Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats.
Increased oxidative stress is implicated in the pathogenesis of diabetic peripheral neuropathy (DPN). However, the efficacy of antioxidant therapy on DPN complicating type 2 diabetes remains unexplored. We therefore determined the ability of the antioxidant taurine to reverse deficits of hind limb sciatic motor and digital sensory nerve conduction velocity (NCV), nerve blood flow (NBF), and sensory thresholds in hyperglycemic Zucker diabetic fatty (ZDF) rats. Experimental groups comprised lean nondiabetic (ND), ND treated with taurine (ND + T), untreated ZDF diabetic (D), and D rats treated with taurine (D + T). Compared to ND rats, 23%, 15% and 56% deficits of motor NCV, sensory NCV and NBF, respectively as well as thermal and mechanical hyperalgesia were reversed by taurine. An 84% deficit of dorsal root ganglion neuron calcitonin gene-related peptide in D rats was prevented by taurine. In summary, the antioxidant taurine reverses neurological and neurovascular deficits in experimental type 2 diabetes.
Li
Fei
F
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Abatan
Omorodola I
OI
Kim
Howard
H
Burnett
Diana
D
Larkin
Dennis
D
Obrosova
Irina G
IG
Stevens
Martin J
MJ
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology*; D051381:Rats; D011924:Rats, Zucker; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000187:drug effects / Q000378:metabolism; D012584:Sciatic Nerve / Q000098:blood supply / Q000187:drug effects; D013654:Taurine / Q000627:therapeutic use*
D000975:Antioxidants; D018015:Receptors, Calcitonin Gene-Related Peptide; D013654:Taurine