Well-defined lactose-containing polymer grafted onto silica particles.
Reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-O-meth-acryloyloxyethoxyl-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-(1-4)-2,3,6-tri-O-acetyl-beta-D-glucopyranoside (MAEL) was performed directly in CHCl3 solutions using cumyl dithiobenzoate (CDB) as the chain transfer agent to give well-defined glycopolymers. The chemical composition and structure of the glycopolymer were characterized by 1HNMR, FTIR, and SEC. The living glycopolymer chains were subsequently grafted onto gamma-methacryloxypropyl-trimethoxy (MPTMS) modified silica particles. The acetyl groups of the poly(MAEL) grafted onto the silica gel particles were converted to the hydroxyl groups with CH3ONa/CH3OH, thus obtaining silica gel particles modified with well-defined lactose-carrying polymer.
Guo
Tian-Ying
TY
Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education of China, China. tyguo@nankai.edu.cn
Liu
Ping
P
Zhu
Jing-Wei
JW
Song
Mou-Dao
MD
Zhang
Bang-Hua
BH
D001565:Benzoates / Q000737:chemistry; D002236:Carbohydrate Conformation; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
C511371:2-O-methacryloyloxyethoxyl-(2,3,4,6-tetra-O-acetylgalactopyranosyl)-(1-4)-2,3,6-tri-O-acetylglucopyranoside; D001565:Benzoates; D008689:Methacrylates; D011108:Polymers; D012821:Silanes; C511372:cumyl dithiobenzoate; C017492:methacryloxypropyltrimethoxysilane; D012822:Silicon Dioxide; D007785:Lactose