title: New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.
abstract: [reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10,000 TON) are observed.
authors.affiliation: Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. aguram@amgen.com
authors.forename: Anil S
authors.initials: AS
authors.lastname: Guram
authors.forename: Anthony O
authors.initials: AO
authors.lastname: King
authors.forename: John G
authors.initials: JG
authors.lastname: Allen
authors.forename: Xianghong
authors.initials: X
authors.lastname: Wang
authors.forename: Laurie B
authors.initials: LB
authors.lastname: Schenkel
authors.forename: Johann
authors.initials: J
authors.lastname: Chan
authors.forename: Emilio E
authors.initials: EE
authors.lastname: Bunel
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul
authors.forename: Robert D
authors.initials: RD
authors.lastname: Larsen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Martinelli
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Reider