Proximal tubular function and salt sensitivity.
Blood pressure response to changes in dietary salt intake is highly variable among individuals. This heterogeneity results from the combined effects of genetic and environmental determinants. In recent years, considerable progress has been made in our understanding of the pathogenic mechanisms leading to the development of salt-sensitive hypertension. Much information has come from the investigation of rare monogenic forms of salt-sensitive hypertension, which has focused attention on alterations of renal sodium handling occurring essentially in the distal nephron. In this paper, we review the experimental, clinical, genetic, and epidemiologic evidence suggesting that proximal tubular function is also an important determinant of the blood pressure response to salt, which deserves greater attention.
Burnier
Michel
M
Service de Néphrologie, CHUV, Rue du Bugnon 17, 1011 Lausanne, Switzerland. michel.burnier@chuv.ch
Bochud
Murielle
M
Maillard
Marc
M
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000503:physiopathology*; D012307:Risk Factors; D012965:Sodium Chloride / Q000378:metabolism*
D012965:Sodium Chloride