Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule.
The synthesis of chiral cyclic oligo(4-beta-methyl)thiazolines is described; linear oligothiazolines were efficiently prepared by the iterative formation of a thiazoline ring and a two-directional block condensation, and construction of 24- to 36-membered cyclic oligothiazoline systems could be achieved by the head-to-tail cyclooligomerization of doubly deprotected linear fragments and subsequent thiazoline formation.
Han
Fu She
FS
PRESTO, the Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Osajima
Hiroyuki
H
Cheung
Mui
M
Tokuyama
Hidetoshi
H
Fukuyama
Tohru
T
D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis*
D047028:Macrocyclic Compounds; D013844:Thiazoles