title: Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.
abstract: We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and beta-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance.
authors.affiliation: Department of Medicine & Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
authors.forename: Kwok Leung
authors.initials: KL
authors.lastname: Ong
authors.forename: Louisa Y F
authors.initials: LY
authors.lastname: Wong
authors.forename: Yu Bun
authors.initials: YB
authors.lastname: Man
authors.forename: Raymond Y H
authors.initials: RY
authors.lastname: Leung
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
authors.forename: Karen S L
authors.initials: KS
authors.lastname: Lam
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005951:Glucose Tolerance Test; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007333:Insulin Resistance; D015810:Linkage Disequilibrium; D008297:Male; D008957:Models, Genetic; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D014579:Urotensins / Q000235:genetics* / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled; C121697:UTS2R protein, human; D014579:Urotensins; C029677:urotensin II