title: Application of mitomycin C after endoscopic lysis of congenital laryngeal web combined with epiglottic hypoplasia in a middle-aged man.
abstract: Laryngeal webs and epiglottic hypoplasias are uncommon congenital anomalies. Anterior glottic web combined with epiglottic hypoplasia was found in a middle-aged man presenting with hoarseness and dyspnea on exertion. This can be considered as a unique isolated defect of the larynx during early fetal development. The laryngeal web can be successfully treated in a single stage with endoscopic lysis and topical application of mitomycin C for prevention of anterior glottic restenosis. This case and prior reports suggest that the novel approach may be effective in the treatment of laryngeal webs.
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea. happyfam@paran.com
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003251:Constriction, Pathologic / Q000151:congenital / Q000517:prevention & control / Q000601:surgery; D004417:Dyspnea / Q000209:etiology; D004825:Epiglottis / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D007828:Laryngoscopy / Q000379:methods*; D007830:Larynx / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D055502:Secondary Prevention; D016896:Treatment Outcome; D014832:Voice Disorders / Q000209:etiology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin