title: [Preoperative hepatic and regional arterial infusion chemotherapy in the prevention of liver metastasis after colorectal cancer surgery].
abstract: OBJECTIVE
  To investigate the effects of preoperative hepatic and regional arterial infusion chemotherapy (PHRAIC) in the prevention of liver metastasis of colorectal cancer after surgery.
  
  
  METHODS
  110 patients of colorectal cancer underwent perfusion of 3 anti-tumor drugs into the hepatic artery and nutrient artery of the tumor respectively, radical surgery of the colorectal cancer 7 days after, and then general venous chemotherapy 3 weeks after operation, 112 patients underwent radical surgery of the colorectal cancer and general venous chemotherapy 3 weeks after operation. Follow-up was carried out every month with a follow-up period of 34 months +/- 3 months.
  
  
  RESULTS
  There were no significant difference in post-operational complications between these 2 groups. The 3-year liver metastasis rate, 3-year tumor-free survival rate, overall survival rate, and median survival time of the stage III patients in the PHRAIC group were 12.7%, 82.3%, 87.7%, and 40 months +/- 5 months, all significantly better than those in the control group (28.3%, 58.7%, 75.5%, and 36 months +/- 3 months respectively, P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  PHRAIC reduces the liver metastasis of colorectal cancer after radical surgery and improves the survival of the stage III patients.
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Xu
authors.forename: Yun-shi
authors.initials: YS
authors.lastname: Zhong
authors.forename: Wei-xin
authors.initials: WX
authors.lastname: Niu
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Yan-han
authors.initials: YH
authors.lastname: Lai
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Zhi-ping
authors.initials: ZP
authors.lastname: Yan
authors.forename: Jie-min
authors.initials: JM
authors.lastname: Cheng
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Qin
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003107:Colorectal Surgery; D005260:Female; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011300:Preoperative Care / Q000379:methods*; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents