Three novel triterpenoid saponins from Lysimachia capillipes and their cytotoxic activities.
Three new saponins, capilliposide A (1), capilliposide B (2) and capilliposide C (3) were isolated from an ethanol extract of Lysimachia capillipes. Their structures were determined by 1D and 2D NMR (1H-1H COSY, HMBC, HMQC, DEPT and TOCSY) techniques, MS, and hydrolysis. Capilliposide B showed significant cytotoxicity against human A-2780 cells.
Tian
Jing-Kui
JK
Department of Chinese Medicine Sciences & Engineering, Zhejiang University, Hangzhou, China. tjk@zju.edu.cn
Xu
Li-Zhen
LZ
Zou
Zhong-Mei
ZM
Yang
Shi-Lin
SL
D002478:Cells, Cultured; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029623:Primulaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D018675:Toxicity Tests; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology
D005419:Flavonoids; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C511100:capilliposide A