title: Stereoselective functionalization of beta-iodo-alpha,beta-unsaturated ketones via an iodine-copper exchange reaction.
abstract: [reaction: see text] Beta-iodo-alpha,beta-unsaturated carbonyl compounds undergo a stereoselective iodine-copper exchange reaction with (Nphyl)(2)CuLi, providing the corresponding alkenyl cuprates with retention of the double bond configuration. No competitive addition/elimination was observed, and the resulting cuprates were successfully functionalized with various electrophiles.
authors.affiliation: Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany.
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Yang
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel