title: Comparative effects of acute and subacute lycopene administration on chromosomal aberrations induced by cisplatin in male rats.
abstract: Lycopene is a natural carotenoid, free radical scavenger, and presents protective effects by inhibiting oxidative DNA damage. The objective of the current study was to investigate the cytogenetic effects of a single acute and four daily gavage administrations of lycopene, and to examine possible protective effects on chromosomal damage induced by the antitumor drug cisplatin (cDDP) in rat bone marrow cells. The animals were divided into treatment groups, with three lycopene doses in the acute treatment (2, 4, and 6 mg/kg b.w.), three lycopene doses in the subacute treatment (0.5, 1.0, and 1.5 mg/kg b.w.) with and without cDDP (5 mg/kg b.w. i.p.), and respective controls. The results indicated that lycopene is neither cytotoxic nor clastogenic when compared with the negative controls (p>0.01). cDDP-treated animals submitted to acute and subacute treatments with different lycopene doses showed a significant reduction (p<0.01) in the number of abnormal metaphases when compared with the animals treated only with cDDP. The protective effects of lycopene on cDDP-induced chromosomal damage may be attributed to its antioxidant activity. These results suggest that this carotenoid may prove useful in reducing some of the toxic effects associated with certain classes of chemotherapeutic agents.
authors.affiliation: Departamento de Alimentos e Nutrição, Faculdade de Ciências, Farmacêuticas de Araraquara, UNESP, Araraquara, SP, Brazil.
authors.forename: Milena Cristina
authors.initials: MC
authors.lastname: Sendão
authors.forename: Estela Beatriz
authors.initials: EB
authors.lastname: Behling
authors.forename: Raquel Alves
authors.initials: RA
authors.lastname: dos Santos
authors.forename: Lusânia Maria Greggi
authors.initials: LM
authors.lastname: Antunes
authors.forename: Maria
authors.initials: M
authors.lastname: de Lourdes Pires Bianchi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D002338:Carotenoids / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D004347:Drug Interactions; D000077276:Lycopene; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D002945:Cisplatin; D000077276:Lycopene