title: Bronchial hyperresponsiveness is a common feature in patients with chronic urticaria.
abstract: BACKGROUND
  Chronic urticaria (CU) is a skin disorder characterized by long-lasting release of histamine, and sometimes leukotrienes, from both mast cells and basophils. Although both these substances are potent inductors of contraction of airway smooth muscle, pulmonary function and airway hyperresponsiveness have not been systematically investigated in patients with CU.
  
  
  OBJECTIVE
  To assess pulmonary function and airway hyperresponsiveness in patients with CU.
  
  
  METHODS
  Twenty-six clinically well-characterized adult patients with CU (M/F 8/18; mean age 47 years) underwent pulmonary function tests and methacholine provocation during a phase of moderate activity of their disease. Twenty-six adult asthmatic patients submitted to methacholine provocation were used as controls.
  
  
  RESULTS
  Two patients (8%) had overt asthma on baseline pulmonary function tests. Twenty (77%) patients with a normal baseline pulmonary function showed significant bronchial hyperresponsiveness on methacholine provocation. Altogether, 22/26 (85%) patients had asthma or abnormal bronchial reactivity. Airway hyperresponsiveness was not associated with gender, disease duration, intolerance to NSAID, positive autologous serum skin test or respiratory allergy. On average, asthmatic controls showed a much severer airway hyperresponsiveness than urticaria patients (p < 0.01).
  
  
  CONCLUSIONS
  Patients with CU frequently show bronchial hyperresponsiveness. Prospective studies are needed to assess whether they are at risk for bronchial asthma.
authors.affiliation: S.C. Pneumologia, A.O. Niguarda Ca Granda, Milano, Italy. r.asero@libero.it
authors.forename: R
authors.initials: R
authors.lastname: Asero
authors.forename: E
authors.initials: E
authors.lastname: Madonini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D012129:Respiratory Function Tests / Q000379:methods; D014581:Urticaria / Q000503:physiopathology*
chemical_list: D016210:Methacholine Chloride