title: Efficacy of retrospective recall of attention-deficit hyperactivity disorder symptoms: A twin study.
abstract: Attention-deficit hyperactivity disorder (ADHD) is currently recognized as a neurobiological, genetically based disorder in both children and adults. In this article we examine whether, by using a sample of middle-aged male twin veterans, the phenotypic characterization, prevalence, heritability and the longitudinal course of the illness is comparable to results observed in samples of children and adolescents. We evaluated the utility of adult reports of lifetime ADHD symptoms by examining the heritability of retrospectively reported childhood symptoms, using both symptom-based and discrete classification-based approaches, as well as examining the persistence of ADHD symptoms into adulthood for that subsample of individuals who were judged to possibly have ADHD as children. Our results showed prevalence rates that were approximately similar to those observed in other studies, demonstrable familiality, similar item endorsement patterns, a strong genetic association between hyperactive and inattentive subtypes, and a longitudinal decline in symptom severity. We concluded that while assessing ADHD in adult probands may be less accurate than with children or adolescents, since it demonstrates several characteristics in common with other assessment techniques it remains a viable diagnostic and research strategy, even with population samples.
authors.affiliation: Psychology Department, Boston University, Boston, United States of America. mschult@bu.edu
authors.forename: Mark R
authors.initials: MR
authors.lastname: Schultz
authors.forename: Keren
authors.initials: K
authors.lastname: Rabi
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: William
authors.initials: W
authors.lastname: Kremen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lyons
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D002648:Child; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014427:Twins / Q000208:ethnology / Q000235:genetics*