Total synthesis of (-)-dictyostatin.
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.
O'Neil
Gregory W
GW
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.
Phillips
Andrew J
AJ
D018942:Macrolides / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
D018942:Macrolides; C470814:dictyostatin