title: Membership in genetic groups predicts Alzheimer disease.
abstract: The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3:GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TT; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.
authors.affiliation: Center for Demographic Studies, Duke University, Durham, North Carolina, USA.
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Corder
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Heather M
authors.initials: HM
authors.lastname: Cathcart
authors.forename: Irene S
authors.initials: IS
authors.lastname: Lanham
authors.forename: Ginny R
authors.initials: GR
authors.lastname: Parker
authors.forename: Danny
authors.initials: D
authors.lastname: Cheng
authors.forename: Suzanne
authors.initials: S
authors.lastname: Smith
authors.forename: Shirley E
authors.initials: SE
authors.lastname: Poduslo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002402:Cathepsin D / Q000235:genetics; D055316:Cystatin C; D015891:Cystatins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D011973:Receptors, LDL; D002402:Cathepsin D