title: [Relationship between serum interleukin-10 and insulin resistance in metabolic syndrome].
abstract: OBJECTIVE
  To investigate the relationship between serum interleukin-10 (IL-10) level and insulin resistance (IR) in patients with metabolic syndrome (MS).
  
  
  METHODS
  Eighteen MS subjects and 18 age-matched normal subjects were enrolled. IR was evaluated by hyperinsulinemic-euglycemic clamp technique and serum IL-10 level measured by ELISA. Pearson's correlation analysis was used to investigate the relationship between serum IL-10 level and IR.
  
  
  RESULTS
  Serum IL-10 levels were significantly higher in patients with MS than in the controls [1.3 (0.8/3.1) pg/ml vs 2.4 (1.1/4.5) pg/ml, P<0.05], and glucose metabolic rate (M value) derived from hyperinsulinemic-euglycemic clamp technique was lower in MS subjects than in controls [(5.76+/-1.81) mg/kg.min vs (8.39+/-1.25) mg/kg.min], P<0.05]. Serum IL-10 levels showed a positive correlation with M value (P<0.05).
  
  
  CONCLUSIONS
  Patients with MS have greater IR and lower serum IL-10 levels than normal subjects, and lowered IL-10 levels might be involved in the pathogenesis of IR in MS.
authors.affiliation: Department of Endocrinology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Ye
authors.forename: Zhi-zhen
authors.initials: ZZ
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
authors.forename: Zu-zhi
authors.initials: ZZ
authors.lastname: Fu
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged
chemical_list: D016753:Interleukin-10