title: [A study of extraesophageal presentations in gastroesophageal reflux disease].
abstract: OBJECTIVE
  The aim of this prospective multi-center study was to evaluate the clinical characteristics of extraesophageal reflux disorders (EED) in gastroesophageal reflux disease (GERD) patients and the therapeutic effect of proton pump inhibitor (PPI) on EED.
  
  
  METHODS
  We investigated GERD patients in 4 hospitals in Shanghai in a same time period. These patients were diagnosed as GERD by finding reflux esophagitis (RE) on endoscopy or with abnormal reflux during 24 h esophageal pH monitoring. Typical GERD symptoms and EED symptoms were evaluated by questionnaire. Patients with EED symptoms underwent videolaryngoscopy and abnormalities were recorded.
  
  
  RESULTS
  Totally 200 subjects were enrolled in this study. Among them 95 patients complained of EED. The RE cases were 134 in number and EED occurred in 65 of the RE patients. The commonest presenting symptom of EED was globus or foreign body feeling in the throat (27%), followed by cough, soar throat and hoarseness. Asthma was a rare symptom, the occurrence being 21%, 16%, 11% and 3% respectively. The rate of typical GERD symptoms existing in EED group was 56%. The severity of EED symptoms showed no significant difference between RE and NERD patients. Abnormalities were found in 58% of subjects with EED on laryngoscopy, the occurrence of arytenoids medial wall erythema/edema was 25%, vocal cord erythema/edema was 32%, posterior pharyngeal wall cobble stoning was 20%, and 42% of the patients showed no abnormalities on laryngoscopy. Higher dosage PPI therapy showed effects on the relief of EED, and the relief rate was 95% after 8 weeks of treatment.
  
  
  CONCLUSIONS
  Our results suggest that a significant part of GERD patients suffered from EED, and value of laryngoscopy and 24 h pH monitoring is limited for the diagnosis of EED. Higher dosage of PPI was effective for the treatment of EED.
authors.affiliation: Division of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Zhao-shen
authors.initials: ZS
authors.lastname: Li
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Xu
authors.forename: Duo-wu
authors.initials: DW
authors.lastname: Zou
authors.forename: Wei-fen
authors.initials: WF
authors.lastname: Xie
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Yu
authors.forename: Xi-mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.forename: Feng-shang
authors.initials: FS
authors.lastname: Zhu
authors.forename: Wu
authors.initials: W
authors.lastname: Wen
authors.forename: Tun
authors.initials: T
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004942:Esophagitis, Peptic / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D011795:Surveys and Questionnaires
chemical_list: D054328:Proton Pump Inhibitors