Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.
In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA (mtDNA) and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiration deficiency caused by mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the generally accepted mitochondrial theory of aging, which proposes that accumulation of somatic mutations in mtDNA is responsible for age-associated mitochondrial dysfunction. Moreover, the presence of mitochondrial complementation enables gene therapy for mitochondrial diseases using nuclear transplantation of zygotes.
Sato
Akitsugu
A
Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan.
Nakada
Kazuto
K
Hayashi
Jun-Ichi
J
D000375:Aging / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D009154:Mutation / Q000235:genetics*
D004272:DNA, Mitochondrial