title: Endometrial scraping cytology in women with extragenital malignancies.
abstract: OBJECTIVE
  To clarify the usefulness of endometrial scraping smears in women with extragenital malignancies.
  
  
  METHODS
  A total of 4,335 endometrial scraping smears were obtained during the 5-year period 1995-1999 at the National Kyushu Cancer Center and were retrospectively analyzed regarding extragenital malignancies.
  
  
  RESULTS
  There were 88 cases of extragenital malignancies. Extragenital malignant cells were detected in endometrial smears in 13 cases. The cases consisted of 4 gastric cancers, 4 breast cancers, 2 lung cancers, 1 rectal cancer, 1 gastrointestinal stromal tumor of the small intestine and 1 case of adenocarcinoma of unknown origin. The patients' average age was 52.5 years. The symptoms and signs included abnormal vaginal bleeding, abdominal and lumbar pain, lower limb edema, abdominal mass and neck lymph node swelling. Both ascites and peritoneal dissemination were found in 8 cases. Ten of the 13 cases were diagnosed as of extrauterine origin based on the characteristic cancer cell appearance, the absence of cellular detritus among the poorly differentiated adenocarcinomas and, above all, the morphologic difference between normal endometrial cells and cancer cells.
  
  
  CONCLUSIONS
  Endometrial scraping smears are useful for detecting extragenital malignant cells that enter the uterine cavity.
authors.affiliation: Gynecology Service and Clinical Laboratory, National Kyushu Cancer Center, Fukuoka, Japan. mokadome@nk-cc.go.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Okadome
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saito
authors.forename: Naoki
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Nishi
authors.forename: Naoko
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Nagata
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology*; D000328:Adult; D001706:Biopsy / Q000379:methods; D003581:Cytodiagnosis / Q000379:methods; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D014626:Vaginal Smears