title: A transient lesion in splenium of the corpus callosum in a patient with childhood-onset anorexia nervosa.
abstract: OBJECTIVE
  Although a transient lesion in the splenium of the corpus callosum (SCC) has been reported predominantly regarding patients with epilepsia, it is of rare occurrence, and its underlying biological basis remains unknown. This is a report of an SCC lesion in a patient with anorexia nervosa (AN).
  
  
  METHODS
  The patient was a 15-year-old girl with childhood-onset (11 years) and a protracted course of AN. On admission, the patient showed no apparent neurological abnormalities. Magnetic resonance imaging (MRI) scans revealed a circumscribed lesion in the SCC. We treated her with nutritional rehabilitation supplemented with B vitamins.
  
  
  RESULTS
  One month later, the lesion completely disappeared, but her weight was not restored.
  
  
  CONCLUSIONS
  Treatment with B-vitamin supplementation may be beneficial for the treatment of patients with AN, in cases in which the disorder develops at an early age before brain maturation (i.e., childhood-onset cases), along with an enduring course of malnutrition.
authors.affiliation: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Nishimura
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kawai
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Haruo
authors.initials: H
authors.lastname: Isoda
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000856:Anorexia Nervosa / Q000188:drug therapy / Q000209:etiology*; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D003337:Corpus Callosum; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D044342:Malnutrition; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex