FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.
We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.
Adryan
Boris
B
MRC Laboratory of Molecular Biology Cambridge CB2 2QH, UK. boris@mrc-lmb.cam.ac.uk
Teichmann
Sarah A
SA
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry; D003627:Data Interpretation, Statistical; D029721:Drosophila Proteins / Q000737:chemistry*; D004331:Drosophila melanogaster / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012984:Software; D014157:Transcription Factors / Q000737:chemistry*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D014157:Transcription Factors; D004247:DNA