Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target?
CC chemokine receptor (CCR) 8, which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. This review represents an overview of the functional roles of CCR8 in the pathogenesis of eosinophilic inflammation and debates the potential of recently developed CCR8 antagonists to treat allergic disorders.
Mitsuyama
E
E
Pharmaceutical Discovery Research Laboratories, Institute for Biomedical Research, Teijin Pharma., Ltd., Tokyo, Japan.
Kunori
Y
Y
Kamimura
T
T
Kaminuma
O
O
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D008969:Molecular Sequence Data; D054401:Receptors, CCR8; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
C103330:CCR8 protein, human; D054401:Receptors, CCR8; D019707:Receptors, Chemokine