[Modulation of endotoxin-induced respiratory splash of granulocytes and monocytes in patients with Familial Mediterranean Fever by iodine-lithium-alpha-dextrin and sodium thiosulfate].
The effect of an endotoxin--E. coli liposaccharide (LPS) of serotype 026:B6--on the respiratory splash (RS) of neutrophils and monocytes in peripheral blood of patients with Familial Mediterranean Fever (FMF) was studied. It is shown that FMF patients have a periodic increase (during an attack) and a decrease (in the period of remission) in endotoxin-induced RS of neutrophils and monocytes. LPS stimulates chemotoxis-induced RS of neutrophils and monocytes in patients both in the period of remission and during the attack equally effectively. Iodine-lithium-alpha-dextrin and sodium thiosulfate have a marked anti-endotoxic effect which manifests with quick neutralization of endotoxin activity on RS of monocytes and neutrophils in FMF patients both during the attack and remission.
Avetisian
S A
SA
Akopian
G S
GS
Davtian
T K
TK
D000293:Adolescent; D000328:Adult; D003912:Dextrins / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D010505:Familial Mediterranean Fever / Q000276:immunology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007455:Iodine; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000276:immunology; D008094:Lithium; D008297:Male; D009000:Monocytes / Q000187:drug effects; D016897:Respiratory Burst / Q000187:drug effects*; D013885:Thiosulfates / Q000494:pharmacology*
D003912:Dextrins; D008070:Lipopolysaccharides; D013885:Thiosulfates; D007455:Iodine; D008094:Lithium; C017717:sodium thiosulfate