[Notch signaling pathway and new strategies in cancer treatment].
The Notch signaling pathway plays a crucial role at different stages of cell development, such as proliferation, growth, differentiation, and apoptosis. Recent studies demonstrate that depending on the expression level and cellular context, the Notch receptors play a role in apoptosis resistance in malignant cells. These findings suggest that Notch signaling components may be a potential target in the development of new cancer therapies. This review describes the function of the Notch pathway and new strategies in the modulation of its signal.
Santos
Leticia
L
División de Biologia Molecular, Instituto Potosino de Investigación Científica y Tecnológica, A.C. San Luis Potosí, S.L.P., México. Isantos@ipicyt.edu.mx
León-Galván
Maria Fabiola
MF
Marino-Marmolejo
Erika Nahomy
EN
D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000209:etiology*; D051880:Receptors, Notch / Q000037:antagonists & inhibitors* / Q000502:physiology*; D015398:Signal Transduction
D051880:Receptors, Notch