[A preliminary study of beam weight optimization of intensity-modulated radiation therapy with genetic algorithm].
To study the method for dose calculation and beam weight optimization of intensity-modulated radiation therapy (IMRT).


METHODS
The IMRT dose calculation model based on two-dimensional convolution was constructed, the program of dose calculation and beam weight optimization with genetic algorithm was written with Visual c#.Net, and the optimization results were analyzed.


RESULTS
Genetic algorithm optimization of beam weights can produce highly conformal dose distributions within a clinically acceptable computation time.


CONCLUSIONS
Genetic algorithm is valid and efficient in IMRT beam weight optimization, which may facilitate IMRT treatment planning.
Tang
Mu-tao
MT
School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Chen
Chao-min
CM
Zhou
Ling-hong
LH
Lü
Qing-wen
QW
Wang
Zhuo-yu
ZY
Chen
Guang-jie
GJ
D000465:Algorithms; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods* / Q000592:standards