[Survivin expression in ovarian carcinoma].
OBJECTIVE
To explore the possible relationship between expression of survivin and molecular mechanisms in patients with ovarian carcinoma (OC).


METHODS
Survivin expressions in normal ovaries (n= 10), ovarian bordline tumors (n = 21), and ovarian serous cystadenomas (n = 38) were investigated by means of immunohistochemistry.


RESULTS
No survivin protein was expressed in normal ovaries. Survivin protein was found in cytoplasm and/or in nucleus of tumor cell. Survivin expression was revealed in 42.9% (9/21) of ovarian bordline tumors; no significant correlation was observed between survivin expression and pathologic types or CA125 values (P > 0.05). Survivin protein was found in 76.3% (29/38) of ovarian serous cystadenomas, displaying a significantly higher expression than that in bordline tumors (P < 0.05). Survivin expression was positively correlated with tumor stage, histological grade and lymphonode metastasis (P < 0.05), whereas it was not significantly correlated with CA125 values, volume of ascites, and presence/absence of tumor cells in ascites (P > 0.05).


CONCLUSIONS
High expression of Survivin protein may be related with the differentiation and metastasis of epithelial ovarian carcinoma.
Yin
Ru-Tie
RT
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Peng
Zhi-Lan
ZL
Yang
Kai-Xuan
KX
Kang
De-Ying
DY
D000328:Adult; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000473:pathology; D018291:Cystadenoma, Mucinous / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D000077022:Survivin