title: [China coronary secondary prevention study: analysis of patients with different myocardial infarction history].
abstract: OBJECTIVE
  To assess whether Xuezhikang was effective in the secondary prevention of coronary heart disease (CHD) for patients with different length of myocardial infarction (MI) history.
  
  
  METHODS
  2135 patients with MI history of 28 days to 3 months and 2735 patients with MI history of 3 months to 60 months were recruited separately to receive treatment with Xuezhikang capsule or placebo. The primary end-points were nonfatal myocardial infarction and death from CHD.
  
  
  RESULTS
  The occurrence of coronary events were found to be not statistically significantly different for the two groups of patients. For patients with MI history of 28 days to 3 months, Xuezhikang significantly reduced the risk of CHD events by 56.7% (P < 0.0001) and resulted in a 48.6% (P = 0.0002) risk reduction in all-cause mortality as compared with placebo. For patients with MI history of 3 months to 60 months, Xuezhikang significantly decreased the risk of CHD events by 35.3% (P = 0.0008) and led to a 20.0% (P = 0.1181) risk reduction in the all-cause mortality as compared with placebo. Adverse effects and abnormal laboratory parameters did not differ significantly in the two groups of patients.
  
  
  CONCLUSIONS
  Xuezhikang is more effective for patients with MI history of 28 days to 3 months as compared with patients with MI history of 3 months to 60 months. Patients with MI history should be treated with Xuezhikang early in order to achieve better prevention of CHD.
authors.affiliation: Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Scinence, Peking Union Medical College, Beijing 100037, China.
authors.forename: Bao-min
authors.initials: BM
authors.lastname: Du
authors.forename: Zong-liang
authors.initials: ZL
authors.lastname: Lu
authors.forename: Zuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Yang-feng
authors.initials: YF
authors.lastname: Wu
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Zhao
authors.forename: Ti-gang
authors.initials: TG
authors.lastname: Huang
mesh_terms: D002681:China; D003327:Coronary Disease / Q000517:prevention & control*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal