title: Azathioprine-induced shock in a patient suffering from undifferentiated erosive oligoarthritis.
abstract: Shock due to a hypersensitivity response to azathioprine is unpredictable, occurs seldom and bears a potentially fatal outcome. Azathioprine is widely used in the treatment of autoimmune diseases and in solid organ transplantation. Here, we present a patient who suffered from undifferentiated erosive oligoarthritis and was treated with azathioprine. This patient developed anaphylactic shock which was interpreted as a side effect of azathioprine. Although rare, similar cases were described since 1980.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Demirtaş-Ertan
authors.forename: A T
authors.initials: AT
authors.lastname: Rowshani
authors.forename: I J M
authors.initials: IJ
authors.lastname: ten Berge
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy*; D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D001379:Azathioprine