title: Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapy.
abstract: We compared 156 human immunodeficiency virus (HIV)-infected patients who had tuberculosis with control populations of similar size. Of 111 patients with HIV infection and tuberculosis who received highly active antiretroviral therapy (HAART) and therapy for tuberculosis concurrently, 92 (83%) achieved or maintained virus loads of <50 copies/mL, and 99 (89%) achieved or maintained a >or=2 log10 reduction in virus load after 6 months. Virological response and changes in CD4 cell count were equivalent to those in 111 matched HIV-infected subjects without tuberculosis starting HAART. Tuberculosis recurrence rates were similar to those found in an HIV-uninfected population of 156 subjects (3% and 1%, respectively). Treatment for HIV and tuberculosis does not compromise outcomes for either disease.
authors.affiliation: Department of HIV Medicine, Royal Free Hospital, and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom. r.breen@medsch.ucl.ac.uk
authors.forename: Ronan A M
authors.initials: RA
authors.lastname: Breen
authors.forename: R F
authors.initials: RF
authors.lastname: Miller
authors.forename: T
authors.initials: T
authors.lastname: Gorsuch
authors.forename: C J
authors.initials: CJ
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Ainsworth
authors.forename: J
authors.initials: J
authors.lastname: Ballinger
authors.forename: L
authors.initials: L
authors.lastname: Swaden
authors.forename: I
authors.initials: I
authors.lastname: Cropley
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
authors.forename: M C I
authors.initials: MC
authors.lastname: Lipman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections; D006801:Humans; D008131:London; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D019562:Viral Load
chemical_list: D000995:Antitubercular Agents