title: Is prenatal smoking associated with a developmental pattern of conduct problems in young boys?
abstract: OBJECTIVE
  Prenatal smoking is robustly associated with increased risk of conduct problems in offspring. Observational studies that provide detailed phenotypic description are critical for generating testable hypotheses about underlying processes through which the effects of prenatal smoking may operate. To this end, we use a developmental framework to examine the association of exposure with (1) oppositional defiant disorder and attention-deficit/hyperactivity disorder in young boys and (2) the pattern of delinquent behavior at adolescence.
  
  
  METHODS
  Using diagnostic measures and repeated measures of delinquency, we compare exposed and nonexposed boys from the youngest cohort of the Pittsburgh Youth Study (N = 448).
  
  
  RESULTS
  Exposed boys were significantly more likely to (1) develop oppositional defiant disorder and comorbid oppositional defiant disorder-attention-deficit/hyperactivity disorder but not attention-deficit/hyperactivity disorder alone and (2) to have an earlier onset of significant delinquent behavior.
  
  
  CONCLUSIONS
  The early emergence and developmental coherence of exposure-related conduct problems is striking and is consistent with a behavioral teratological model. Phenotypically, exposure-related conduct problems appear to be characterized by socially resistant and impulsively aggressive behavior. Whether prenatal smoking plays an etiological role in or is a risk marker for the development of conduct problems, exposed offspring are at increased risk of an early-starter pathway to conduct problems.
authors.affiliation: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, IL 60608, USA. lwakschlag@psych.uic.edu
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Wakschlag
authors.forename: Kate E
authors.initials: KE
authors.lastname: Pickett
authors.forename: Kristen E
authors.initials: KE
authors.lastname: Kasza
authors.forename: Rolf
authors.initials: R
authors.lastname: Loeber
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000987:Antisocial Personality Disorder / Q000209:etiology / Q000523:psychology; D002653:Child Behavior Disorders / Q000209:etiology / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology; D019955:Conduct Disorder / Q000209:etiology* / Q000523:psychology; D003865:Major Depressive Disorder; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000009:adverse effects* / Q000208:ethnology