title: The influence of surface coatings of dicalcium phosphate (DCPD) and growth and differentiation factor-5 (GDF-5) on the stability of titanium implants in vivo.
abstract: Mechanical stability of implants is usually tested by pull out or push out tests which destroy the interface between the implant and bone. Pull out tests do not ideally reflect the clinical situation. In contrast, applying submaximal load leads to more physiologic micro-displacement between implant and bone. The aim of this study was to evaluate a new non-destructive mechanical testing device on different modifications of titanium implants. In 18 rabbits we investigated the influence of a dicalcium phosphate (DCPD) coating, or of a growth and differentiation factor-5 (GDF-5) coating, or a combination of both on the stability of titanium implants. The stability of implant was assessed by a non-destructive micro-measurement. In the same specimens the interface was investigated by micro-CT and histological evaluation. Surface modifications had a positive effect on the implant stability regarding displacement (p=0.001). Mechanical stability correlated with the quality of peri-implant tissue. Micro-displacement correlated negatively with the bone formation around the implants in histomorphometric evaluation (p=0.02). Amount of peri-prosthetic soft tissue showed a positive correlation with micro-displacement (p=0.01). Our findings indicate the positive effect of DCPD and GDF-5 coatings on stability of titanium implants. Results demonstrate the non-destructive testing to be an effective method to evaluate mechanical stability of implants.
authors.affiliation: Orthopaedisches Centrum Hochfranken (OCH), Orthopaedische Gemeinschafspraxis, Eppenreuther Strasse 28, 95032 Hof, Germany. hans-georg.simank@t-online.de
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Simank
authors.forename: Marco
authors.initials: M
authors.lastname: Stuber
authors.forename: Ronny
authors.initials: R
authors.lastname: Frahm
authors.forename: Lars
authors.initials: L
authors.lastname: Helbig
authors.forename: Harry
authors.initials: H
authors.lastname: van Lenthe
authors.forename: Ralph
authors.initials: R
authors.lastname: Müller
mesh_terms: D000268:Adhesiveness; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry* / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005269:Femur / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D055428:Growth Differentiation Factor 5; D008422:Materials Testing; D009038:Motion; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*
chemical_list: D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D055428:Growth Differentiation Factor 5; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous