title: Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.
abstract: The purpose of this study was to construct microemulsion-base hydrogel formulation for topical delivery of ibuprofen. Ethyl oleate (EO) was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulison systems and excellent skin permeation rate of ibuprofen. The pseudo-ternary phase diagrams for microemulsion regions were constructed using ethyl oleate as the oil, Tween 80 as the surfactant, propylene glycol as the cosurfactant. Various microemulsion formulations were prepared and the abilities of various microemulsions to deliver ibuprofen through the skin were evaluated in vitro using Franz diffusion cells fitted with porcine skins. The in vitro permeation data showed that microemulsions increased the permeation rate of ibuprofen 5.72-30.0 times over the saturated solution. The optimum formulation consisted of 3% ibuprofen, 6% EO, 30% Tween 80/PG (2:1) and water, showed a high permeation rate of 38.06 microg cm(-2) h(-1). Xanthan gum as a gel matrix was used to construct the microemulsion-based hydrogel for improving the viscosity of microemulsion for topical administration. The studied microemulsion-based hydrogel showed a good stability. These results indicate that the studied microemulsion-based hydrogel may be a promising vehicle for topical delivery of ibuprofen.
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
authors.forename: Xueling
authors.initials: X
authors.lastname: Chang
authors.forename: Danrong
authors.initials: D
authors.lastname: Du
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Huibi
authors.initials: H
authors.lastname: Xu
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000287:Administration, Topical; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry / Q000493:pharmacokinetics; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000493:pharmacokinetics*; D007052:Ibuprofen / Q000008:administration & dosage*; D009829:Oleic Acids; D010539:Permeability; D011136:Polysorbates; D019946:Propylene Glycol; D012867:Skin / Q000378:metabolism; D013552:Swine
chemical_list: D004655:Emulsions; D009829:Oleic Acids; D011136:Polysorbates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019946:Propylene Glycol; D007052:Ibuprofen; C033180:ethyl oleate