title: [Histopathological changes due to transurethural microwave thermotherapy associated with androgen deprivation therapy in patients with localized prostate cancer].
abstract: OBJECTIVE
  The 2nd generation transurethral microwave thermotherapy (TUMT), equipped with high energy microwave generator and urethral cooling device is widely accepted as an less invasive effective modality to treat benign prostatic hyperplasia. For prostatic cancer, however, it is generally estimated as insufficient because of limitation in penetration of microwave into deep prostatic tissue. In this study, we examined histopathologic changes after androgen deprivation theraphy (ADT) and TUMT.
  
  
  METHODS
  Ten patients with localized prostate cancer underwent ADT for 3 months, and then TUMT was proceeded using Urowave (Dornier MedTech GmbH). Additional 3 months after TUMT and continued ADT, TURP in radical fashion was performed in all the patients, and all the resected chips were submitted for pathological study.
  
  
  RESULTS
  Significant reduction in prostate volume was noted after NHT for 3 months from 37.4 +/- 9.6 ml to 22.0 +/- 5.6 ml. The pathological study of resected chips revealed progressive fibrotic changes without viable cancer cells in 9 of 10 patients. In 1 patient, however, some remnant of carcinomatous foci were noted in a resected chip from the middle lobe of the prostate.
  
  
  CONCLUSIONS
  Although the number of patient is limited and longer follow-up is needed, the results in present series was interested and worth considering.
authors.affiliation: The Center for Urology and Nephrology, Saitama Ken-oh Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Jujo
authors.forename: Ken
authors.initials: K
authors.lastname: Koshiba
authors.forename: Ryuta
authors.initials: R
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Hoshiai
authors.forename: Tadao
authors.initials: T
authors.lastname: Endo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Aihara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Katsuta
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Nakajo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D020728:Transurethral Resection of Prostate
chemical_list: D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal