Candidate susceptibility genes in Alzheimer's disease are at high risk for being forgotten-- they don't give peace of mind...
Alzheimer's disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.
Palotás
András
A
Alzheimer's Disease Research Center, Department of Psychiatry, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary. palotas@nepsy.szote.u-szeged.hu
Kálmán
János
J
D000544:Alzheimer Disease / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D002470:Cell Survival / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D008040:Genetic Linkage / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008565:Membrane Proteins / Q000235:genetics; D018377:Neurotransmitter Agents / Q000235:genetics / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D053764:Presenilin-1
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D008565:Membrane Proteins; D018377:Neurotransmitter Agents; C508853:PSEN1 protein, human; D053764:Presenilin-1