title: Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases.
abstract: We describe a 29-year-old woman who presented with progressive neck pain, sensory deficit and weakness in both arms. Magnetic resonance imaging (MRI) of the cervical spine revealed an extramedullary tumor with severe spinal cord compression. During surgery an intradural extramedullary tumor was found. Further imaging showed a second lumbar spinal tumor. Microscopy of both tumors showed that both tumors were anaplastic ependymomas, which almost never present as extramedullary tumors. Two years after surgery, an intracranial extracerebral metastasis was found, without evidence of spinal recurrence.
authors.affiliation: Department of Neurology, Sint Lucas Andreas Ziekenhuis, Amsterdam, The Netherlands. m.schuurmans@slaz.nl
authors.forename: Mascha
authors.initials: M
authors.lastname: Schuurmans
authors.forename: Jan A L
authors.initials: JA
authors.lastname: Vanneste
authors.forename: Marco J T
authors.initials: MJ
authors.lastname: Verstegen
authors.forename: Wouter R
authors.initials: WR
authors.lastname: van Furth
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary*; D002574:Cervical Vertebrae; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D009418:S100 Proteins / Q000378:metabolism; D013120:Spinal Cord Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
chemical_list: D019394:Ki-67 Antigen; D009418:S100 Proteins