title: Synergy of arbekacin-based combinations against vancomycin hetero-intermediate Staphylococcus aureus.
abstract: This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinupristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillin-sulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.
authors.affiliation: Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Won Sup
authors.initials: WS
authors.lastname: Oh
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Sang Taek
authors.initials: ST
authors.lastname: Heo
authors.forename: Chi Sook
authors.initials: CS
authors.lastname: Moon
authors.forename: Hyun Kyun
authors.initials: HK
authors.lastname: Ki
authors.forename: Sungmin
authors.initials: S
authors.lastname: Kiem
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Song
mesh_terms: D000617:Aminoglycosides / Q000008:administration & dosage*; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003982:Dibekacin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013407:Sulbactam / Q000008:administration & dosage; D017334:Teicoplanin / Q000008:administration & dosage; D014640:Vancomycin / Q000008:administration & dosage*; D014769:Virginiamycin / Q000008:administration & dosage
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D003982:Dibekacin; D017334:Teicoplanin; C035444:sultamicillin; D014640:Vancomycin; D000667:Ampicillin; C031986:arbekacin; D013407:Sulbactam