Safety assessment of the oral cavity probiotic Streptococcus salivarius K12.
Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.
Burton
Jeremy P
JP
BLIS Technologies, Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand. jeremy.burton@blis.co.nz
Wescombe
Philip A
PA
Moore
Chris J
CJ
Chilcott
Chris N
CN
Tagg
John R
JR
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003257:Consumer Product Safety; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D019936:Probiotics / Q000008:administration & dosage* / Q000009:adverse effects*; D012463:Saliva / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity
D000900:Anti-Bacterial Agents