title: Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.
abstract: Polycomb group (PcG) proteins participate in the maintenance of transcriptionally repressed state of genes relevant to cell differentiation. Here, we show anterior homeotic transformations of the axial skeleton of YY1(+/-) mice. We find that the penetrance of some of these alterations was reduced in mice that are deficient in the class II PcG gene Ring1/Ring1A, indicating a genetic interaction between those two genes. Further support for this interaction is an abnormal anterior eye formation in Ring1-deficient mice, which is enhanced in compound YY1(+/-)Ring1(-/-) mice. In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates.
authors.affiliation: Developmental and Cell Biology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Lorente
authors.forename: Claudia
authors.initials: C
authors.lastname: Pérez
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez
authors.forename: Mary
authors.initials: M
authors.lastname: Donohoe
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.forename: Miguel
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000818:Animals; D000869:Anterior Eye Segment / Q000002:abnormalities*; D001846:Bone Development / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009139:Musculoskeletal Abnormalities / Q000235:genetics*; D009154:Mutation; D063150:Polycomb Repressive Complex 1; D063146:Polycomb-Group Proteins; D011247:Pregnancy; D012097:Repressor Proteins / Q000502:physiology*; D013131:Spine / Q000002:abnormalities*; D050986:YY1 Transcription Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; D050986:YY1 Transcription Factor; C494699:Yy1 protein, mouse; D063150:Polycomb Repressive Complex 1; C489840:Ring1 protein, mouse