title: A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.
abstract: Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
authors.affiliation: Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Longhu
authors.initials: L
authors.lastname: Zhou
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Keith
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
authors.forename: Paul F
authors.initials: PF
authors.lastname: Torrence
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018155:Orthopoxvirus / Q000187:drug effects* / Q000502:physiology*; D047069:Pyrazolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D047069:Pyrazolones; D011743:Pyrimidines; C030986:pyrimidine