title: G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits.
abstract: Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takano
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ueda
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Niitsuma
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Qin
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tadokoro
authors.forename: Masashi
authors.initials: M
authors.lastname: Shiomi
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D009203:Myocardial Infarction / Q000517:prevention & control*; D011817:Rabbits / Q000378:metabolism*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D008055:Lipids; D016179:Granulocyte Colony-Stimulating Factor