title: Impact of model for end-stage liver disease (MELD) scoring system on pathological findings at and after liver transplantation.
abstract: The Model for End-Stage Liver Disease (MELD) scoring system, a validated objective liver disease severity scale, was adopted in February 2002 to allocate cadaveric organs for liver transplantation (LT). To improve transplantability before succumbing to advanced disease, patients with low-stage hepatocellular carcinoma (HCC) are given extra points in this system commensurate with their predicted mortality. Our aims were to determine 1) any change in the pathological findings at LT following the implementation of this system and 2) the impact of scoring advantage given to early-stage HCC. Clinicopathologic findings were compared before (pre-MELD, n = 87) and after (MELD, n = 58) the introduction of the MELD system. The findings in the pre-MELD vs. MELD groups were as follows: HCC, 27.5% vs. 48.3% (P = 0.001); portal vein thrombosis (PVT), 13.7% vs. 25.9% (P = 0.08); cholestasis, 16.1% vs. 32.7% (P = 0.026); inflammation grade of 2 or more, 43.7% vs. 48.3% (P = not significant); hepatitis C (HCV), 45.9% vs. 51.7% (P = not significant); HCV with lymphoid aggregates, 25% vs. 60% (P = 0.003); HCV with hyperplastic hilar nodes, 15.0% vs. 36.6% (P = 0.001); and post-LT HCC recurrence, 4.1% vs. 3.4% (P = not significant). Non-HCC-related findings were further compared in the 2 subgroups of pre-MELD (n = 57) and MELD (n = 31) after exclusion of HCC and fulminant hepatic failure (FHF) cases, and only cholestasis was significantly increased in the subgroup MELD. In conclusion, increased incidence of native liver cholestasis in the MELD era may be the histologic correlate of clinically severe liver disease. The scoring advantage given to low-stage HCC did result in a significantly increased incidence of HCC in the MELD group, but it did not adversely affect the post-LT recurrence rate.
authors.affiliation: Department of Anatomic Pathology, Lahey Clinic Medical Center, Burlington, MA 01805, USA. urmila.khettry@lahey.org
authors.forename: Urmila
authors.initials: U
authors.lastname: Khettry
authors.forename: Gissou
authors.initials: G
authors.lastname: Azabdaftari
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Simpson
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Pomfret
authors.forename: James J
authors.initials: JJ
authors.lastname: Pomposelli
authors.forename: W David
authors.initials: WD
authors.lastname: Lewis
authors.forename: Roger L
authors.initials: RL
authors.lastname: Jenkins
authors.forename: Fredric D
authors.initials: FD
authors.lastname: Gordon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000473:pathology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011183:Postoperative Complications; D012720:Severity of Illness Index