title: Total synthesis of (-)-dictyostatin.
abstract: A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.
authors.forename: Gregory W
authors.initials: GW
authors.lastname: O'Neil
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Phillips
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
chemical_list: D018942:Macrolides; C470814:dictyostatin