title: Derivatization does not influence antimicrobial and antifungal activities of applanoxidic acids and sterols from Ganoderma spp.
abstract: Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity against Escherichia coli and Staphylococcus aureus and the antifungal activity against Candida albicans and Trichophyton mentagrophytes of the derivatives were investigated by a microdilution method, and compared with those of the natural products. Both natural and modified compounds exhibited comparable antibacterial and antifungal activities in a range of 1.0 to > 2.0 mg/ml minimal inhibitory concentration.
authors.affiliation: Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88040-900, Brazil. artursmania@hotmail.com
authors.forename: Artur
authors.initials: A
authors.lastname: Smania Júnior
authors.forename: Elza F A
authors.initials: EF
authors.lastname: Smania
authors.forename: Franco
authors.initials: F
authors.lastname: Della Monache
authors.forename: Moacir G
authors.initials: MG
authors.lastname: Pizzolatti
authors.forename: Giuliano
authors.initials: G
authors.lastname: Delle Monache
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D032902:Ganoderma / Q000737:chemistry* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013261:Sterols; D014315:Triterpenes