Triploidy formation after intracytoplasmic sperm injection may be a surrogate marker for implantation.
OBJECTIVE
Triploidy after intracytoplasmic sperm injection (ICSI) is due mostly to retention of the second polar body. Our interest was to determine the predictors of triploidy and to determine whether the presence of triploidy can serve as a surrogate marker of implantation for the remaining cohort of zygotes.


METHODS
Cohort study.


METHODS
Academic research center.


METHODS
Infertile couples undergoing IVF/ICSI.


METHODS
None.


METHODS
Triploid zygote (3PN) rate, implantation rate.


RESULTS
The 3PN rate is a significant predictor of implantation rate for the remaining cohort of zygotes. The starting and total dose of gonadotropins administered and the total days of stimulation are independent predictors of the 3PN rate.


CONCLUSIONS
In couples with a normal semen analysis undergoing IVF/ICSI, the 3PN rate may serve as a surrogate marker of oocyte quality and may be altered by adjusting the stimulation protocol.
Rosen
Mitchell P
MP
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA.
Shen
Shehua
S
Dobson
Anthony T
AT
Fujimoto
Victor Y
VY
McCulloch
Charles E
CE
Cedars
Marcelle I
MI
D000328:Adult; D015415:Biomarkers; D015331:Cohort Studies; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011003:Ploidies; D011237:Predictive Value of Tests; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors; D015053:Zygote / Q000502:physiology* / Q000648:ultrastructure
D015415:Biomarkers