title: Validation of the CAS neonatal NIRS system by monitoring vv-ECMO patients: preliminary results.
abstract: The CAS neonatal NIRS system determines absolute regional brain tissue oxygen saturation (SnO2) and brain true venous oxygen saturation (SnvO2) non-invasively. Since NIRS-interrogated tissue contains both arterial and venous blood from arterioles, venules, and capillaries, SnO2 is a mixed oxygen saturation parameter, having values between arterial oxygen saturation (SaO2) and cerebral venous oxygen saturation (SvO2). To determine a reference for SnO2, the relative contribution of SvO2 to SaO2 drawn from a brain venous site vs. systemic SaO2 is approximately 70:30 (SvO2:SaO2). If the relationship of the relative average contribution of SvO2 and SaO2 is known and does not change to a large degree, then NIRS true venous oxygen saturation, SnvO2, can be determined non-invasively using SnO2 along with SaO2 from a pulse oximeter.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Benni
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Francine D
authors.initials: FD
authors.lastname: Dykes
authors.forename: Scott F
authors.initials: SF
authors.lastname: Wagoner
authors.forename: Micheal
authors.initials: M
authors.lastname: Heard
authors.forename: April J
authors.initials: AJ
authors.lastname: Tanner
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Young
authors.forename: Khodayar
authors.initials: K
authors.lastname: Rais-Bahrami
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Rivera
authors.forename: Billie L
authors.initials: BL
authors.lastname: Short
mesh_terms: D001785:Blood Gas Monitoring, Transcutaneous / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D001921:Brain / Q000378:metabolism; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data
chemical_list: D010100:Oxygen