Magnetic resonance renography findings and their clinical associations in nephropathia epidemica.
OBJECTIVE
To evaluate, with magnetic resonance renography (MRR), the dynamics of renal function in patients with nephropathia epidemica (NE) and to correlate the findings with the clinical course of NE.


METHODS
MRR was performed on 20 hospitalized NE patients during the acute phase of the disease. A repeat MRR study was done 5-8 months later. Primary and repeat MRR studies were compared and functional findings evaluated.


RESULTS
The uptake slope of the contrast enhancement curve was abnormal in the primary study in 14 patients, maximum level of enhancement in 11, decreasing slope of contrast enhancement curve in 14, and signal drop at time in 10 patients when the primary and repeat studies were compared. The greater change in the uptake slope of contrast enhancement, maximum level of enhancement, decreasing slope of enhancement, and signal drop at time between primary and repeat MRR studies evinced a mild association with the severity of clinical renal insufficiency and fluid volume overload.


CONCLUSIONS
Measurable functional MRR findings were recorded in 14/20 NE patients. The severity of the findings was mildly associated with the degree of clinical renal insufficiency and fluid volume overload.
Paakkala
A
A
Medical School, University of Tampere, Finland. antti.paakkala@pshp.fi
Ryymin
P
P
Dastidar
P
P
Huhtala
H
H
Mustonen
J
J
D058186:Acute Kidney Injury / Q000473:pathology* / Q000821:virology; D003287:Contrast Media; D019786:Gadolinium DTPA; D006480:Hemorrhagic Fever with Renal Syndrome / Q000473:pathology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D018709:Statistics, Nonparametric
D003287:Contrast Media; D019786:Gadolinium DTPA