title: Antiproliferative activity of berberine in vitro and in vivo.
abstract: Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.
authors.affiliation: Department of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. silvia.letasiova@stuba.sk
authors.forename: Silvia
authors.initials: S
authors.lastname: Letasiová
authors.forename: Sona
authors.initials: S
authors.lastname: Jantová
authors.forename: Marta
authors.initials: M
authors.lastname: Múcková
authors.forename: Marica
authors.initials: M
authors.lastname: Theiszová
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D008546:Melanoma, Experimental; D051379:Mice; D009368:Neoplasm Transplantation
chemical_list: D000970:Antineoplastic Agents; D001599:Berberine