Learning and memory.
Learning and memory processes are thought to underlie a variety of human psychiatric disorders, including generalised anxiety disorder and post-traumatic stress disorder. Basic research performed in laboratory animals may help to elucidate the aetiology of the respective diseases. This chapter gives a short introduction into theoretical and practical aspects of animal experiments aimed at investigating acquisition, consolidation and extinction of aversive memories. It describes the behavioural paradigms most commonly used as well as neuroanatomical, cellular and molecular correlates of aversive memories. Finally, it discusses clinical implications of the results obtained in animal experiments in respect to the development of novel pharmacotherapeutic strategies for the treatment of human patients.
Wotjak
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Research Group Neuronal Plasticity/Mouse Behaviour, Max-Planck-Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany. wotjak@mpipsykl.mpg.de
D000818:Animals; D001362:Avoidance Learning; D006801:Humans; D007858:Learning; D008568:Memory; D023421:Models, Animal