title: Novel and expeditious microwave-assisted three-component reactions for the synthesis of spiroimidazolin-4-ones.
abstract: Highly efficient methods for the syntheses of spiroimidazolinones via microwave-assisted three-component one-pot sequential reactions or one-pot domino reactions are described. The efficiency and utility of the methods have been demonstrated by quickly accessing the antihypertensive drug irbesartan (2).
authors.affiliation: ArQule, Incorporated, Division of Chemical Technologies, 19 Presidential Way, Woburn, Massachusetts 01801, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Katie
authors.initials: K
authors.lastname: Sargent
authors.forename: Ethan
authors.initials: E
authors.lastname: Stewart
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Daniel
authors.initials: D
authors.lastname: Yohannes
authors.forename: Libing
authors.initials: L
authors.lastname: Yu