title: Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.
abstract: We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.
authors.affiliation: Laboratoire de Biologie Tumorale, Centre de lutte contre le cancer Paul Strauss, 3 rue de la Porte de l'Hôpital, 67065 Strasbourg Cedex, France. btumorale@strasbourg.fnclcc.fr
authors.forename: D
authors.initials: D
authors.lastname: Muller
authors.forename: R
authors.initials: R
authors.lastname: Millon
authors.forename: S
authors.initials: S
authors.lastname: Théobald
authors.forename: T
authors.initials: T
authors.lastname: Hussenet
authors.forename: B
authors.initials: B
authors.lastname: Wasylyk
authors.forename: S
authors.initials: S
authors.lastname: du Manoir
authors.forename: J
authors.initials: J
authors.lastname: Abecassis
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D016213:Cyclins / Q000096:biosynthesis* / Q000235:genetics*; D018450:Disease Progression; D005784:Gene Amplification; D020869:Gene Expression Profiling; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D016133:Polymerase Chain Reaction; D012326:RNA Splicing
chemical_list: C468873:CCNL1 protein, human; D016213:Cyclins