Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.
At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.
Pantaleo
Giuseppe
G
Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland. giuseppe.pantaleo@chuv.ch
Harari
Alexandre
A
D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D014777:Virus Diseases / Q000276:immunology* / Q000517:prevention & control*; D014780:Viruses / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte