title: Life-span extension in yeast.
authors.forename: David A
authors.initials: DA
authors.lastname: Sinclair
authors.forename: Su-Ju
authors.initials: SJ
authors.lastname: Lin
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D031204:Caloric Restriction; D004270:DNA, Circular / Q000502:physiology; D004275:DNA, Ribosomal / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D006655:Histone Deacetylases / Q000235:genetics* / Q000502:physiology; D008136:Longevity / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology; D056565:Sirtuin 2; D037761:Sirtuins / Q000235:genetics* / Q000502:physiology
chemical_list: D004270:DNA, Circular; D004275:DNA, Ribosomal; D004268:DNA-Binding Proteins; C105579:FOB1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases