title: External beam radiotherapy boosts to reduce the impact caused by edema in prostate permanent seed implants.
abstract: In prostate permanent seed implants, it has been shown that edema caused by the surgical procedure decreases dose coverage and hence may reduce treatment efficacy. This reduction in treatment efficacy has been characterized by an increase in tumour cell survival, and biomathematical models have been developed to calculate the tumour cell survival increases in seed implanted prostates of different edema magnitudes and durations. External beam boosts can be utilized to neutralize the negative impact of edema so that originally desired treatment efficacy can be achieved. In this study, a linear quadratic model is used to determine fractionation sizes of the external beam boosts for both (125)I and (103)Pd seed implants. Calculations were performed for prostates of different edema magnitudes and durations, and for tumour cells of different repair rates and repopulation rates.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Yue
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mori
authors.forename: Ravinder
authors.initials: R
authors.lastname: Nath
authors.forename: Dwight E
authors.initials: DE
authors.lastname: Heron
authors.forename: M Saiful
authors.initials: MS
authors.lastname: Huq
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods; D003198:Computer Simulation; D019583:Dose Fractionation, Radiation; D004487:Edema / Q000209:etiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008954:Models, Biological; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D018714:Radiotherapy, Adjuvant / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods*