title: Role of staged endoprosthetic revision with flap cover for limb salvage in endoprosthetic failure.
abstract: Endoprosthetic replacement (EPR) is commonly required for limb salvage in bone malignancies. Endoprosthetic failure is a term used to denote mechanical failure or infection usually requiring removal of the prosthesis. Treatment of infection consists of EPR revision with or without placement of a temporary spacer. Flap cover (either local or free) may be required if the overlying soft tissues are of concern. It is claimed that the investment of the endoprosthesis in well-vacularised soft tissue facilitates the eradication of infection. This series included nine patients with endoprosthetic failure due to chronic infection who needed flap cover. These patients underwent revision of the EPR in two stages. The first stage of revision included removal of the endoprosthesis, insertion of a spacer and soft tissue reconstruction. If serial sampling of the periprosthetic space failed to demonstrate microbial growth, the spacer was exchanged for an endoprosthesis. A total of nine patients underwent staged revision of endoprosthesis. In five patients cover was provided by a local pedicled flap and in four by a free flap. Patients undergoing cover by a broad flat musculocutaneous flap (i.e. free/pedicled latissimus dorsi) performed better. This study reports the results of attempted limb salvage in endoprosthetic failure due to infection in nine cases. Initial findings in this small series indicate that staged revision and soft tissue reconstruction in the form of muscle flap investment of the endoprosthesis carries a higher rate of successful limb salvage.
authors.affiliation: Clinical Fellow, Plastic Surgery, Lancashire Teaching Hospitals NHS Trust, Preston, UK. krisrao@doctors.net.uk
authors.forename: Krishna
authors.initials: K
authors.lastname: Rao
authors.forename: Anindya
authors.initials: A
authors.lastname: Lahiri
authors.forename: Francis C
authors.initials: FC
authors.lastname: Peart
mesh_terms: D000293:Adolescent; D000328:Adult; D001186:Artificial Limbs; D001859:Bone Neoplasms / Q000534:rehabilitation / Q000601:surgery*; D005260:Female; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000517:prevention & control / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods; D012086:Reoperation; D013524:Surgical Flaps