Potential protection of skin by acute UVA irradiation--from cellular to animal models.
The UVA (320-380 nm) component of sunlight has oxidizing properties which may be deleterious to skin cells and tissue but can also lead to the strong up-regulation of the heme-catabolizing enzyme, heme oxygenase-1. This enzyme has well-established antioxidant actions in cells as well as anti-inflammatory properties in mammals. There is also evidence from rodent models that this enzyme is responsible for the UVA-mediated protection against UVB-induced immunosuppression that occurs in skin. The relevance of these findings to acute and chronic effects of sunlight including skin carcinogenesis is currently under investigation as are the potential implications for sunlight protection in humans.
Tyrrell
R M
RM
Department of Pharmacy and Pharmacology University of Bath, BA2 7AY, UK. R.M.Tyrrell@bath.ac.uk
Reeve
V E
VE
D000818:Animals; D051547:Heme Oxygenase-1 / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D023421:Models, Animal; D018384:Oxidative Stress / Q000276:immunology* / Q000528:radiation effects; D011829:Radiation Dosage; D012867:Skin / Q000276:immunology* / Q000528:radiation effects*; D012871:Skin Diseases / Q000276:immunology* / Q000517:prevention & control*; D014466:Ultraviolet Rays
D051547:Heme Oxygenase-1