title: First-trimester Doppler investigation of the uterine circulation.
abstract: There is now strong evidence that fetal events can significantly impact postnatal health and disease development. Doppler velocimetry can identify some early pathologic changes in pregnancy. Many investigators have tried to delineate the normal and pathologic models of the uterine circulation in the first trimester, but much has yet to be defined. A discrete amount of confusion derives from the incomplete knowledge of the initial placental development, and particularly the development of the intervillous circulation. This article comprehensively reviews the literature on first-trimester Doppler in both normal and complicated pregnancies, and briefly discusses potential future areas of application.
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA. ldetti@med.wayne.edu
authors.forename: Laura
authors.initials: L
authors.lastname: Detti
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Johnson
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Puscheck
mesh_terms: D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D010929:Placentation; D011225:Pre-Eclampsia / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging; D011261:Pregnancy Trimester, First; D012039:Regional Blood Flow; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging*