Daclizumab in the induction phase of immunosuppression in heart transplant recipients.
OBJECTIVE
Acute rejection episodes negatively effect both short-term survival and development of graft vasculopathy.


METHODS
We assessed the incidence and severity of acute rejection episodes under a new protocol using a monoclonal antibody daclizumab in the induction phase of immunosuppressive therapy. The study group B (26 patients) was given daclizumab (1 mg/kg), the control group A (25 patients) was treated without daclizumab. There was no significant difference between the two groups in the important data. A total of first 10 EMB in every patient was classified according to the ISHLT recommendation. We also analysed the incidence of infections.


RESULTS
During the first two months there was a significant lower incidence and/or severity of rejection episodes in the daclizumab group with p < or = 0.0016, 0.001 and 0.005 respectively.


CONCLUSIONS
Induction therapy with daclizumab significantly reduces the incidence of acute rejection episodes during the first two posttransplant months in heart transplant recipients. It does not increase the risk of infection.
Petrikovits
Erik
E
Center of Cardiovascular and Transplant Surgery, Brno, Czech Republic. erik.petr@post.cz
Bedanova
Helena
H
Necas
Josef
J
Studenik
Pavel
P
Cerny
Jan
J
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D000077561:Daclizumab; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D016027:Heart Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D000077561:Daclizumab