Lung cancer as an immune reconstitution disease in an HIV-1 positive man receiving HAART.
A case of small-cell lung cancer with prompt worsening of the clinical course was observed in a patient with significant immune restoration after receiving effective highly active antiretroviral therapy (HAART) for seven months. Rapid and enormous enlargement of metastatic liver was the main symptom. Chest x-ray showed an enlargement of the left hilus. The patient died 22 days after the onset of the fulminant disease. We suggest that the occurrence and aggressive course of the lung cancer resulted from the development of immune reconstitution syndrome.
Knysz
Brygida
B
Department of Infectious Diseases, Wrocław Medical University, Poland. brygida@wroclaw.dialog.net.pl
Zalewska
Małgorzata
M
Rzeszutko
Marta
M
Gładysz
Andrzej
A
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000276:immunology* / Q000556:secondary*; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000276:immunology*; D008207:Lymphatic Metastasis; D008297:Male; D019438:Ritonavir / Q000008:administration & dosage; D019258:Saquinavir / Q000008:administration & dosage; D015215:Zidovudine / Q000008:administration & dosage
D019259:Lamivudine; D015215:Zidovudine; D019258:Saquinavir; D019438:Ritonavir