Pulsatile blood flow in the entire coronary arterial tree: theory and experiment.
The pulsatility of coronary circulation can be accurately simulated on the basis of the measured branching pattern, vascular geometry, and material properties of the coronary vasculature. A Womersley-type mathematical model is developed to analyze pulsatile blood flow in diastole in the absence of vessel tone in the entire coronary arterial tree on the basis of previously measured morphometric data. The model incorporates a constitutive equation of pressure and cross-section area relation based on our previous experimental data. The formulation enables the prediction of the impedance, the pressure distribution, and the pulsatile flow distribution throughout the entire coronary arterial tree. The model is validated by experimental measurements in six diastolic arrested, vasodilated porcine hearts. The agreement between theory and experiment is excellent. Furthermore, the present pulse wave results at low frequency agree very well with previously published steady-state model. Finally, the phase angle of flow is seen to decrease along the trunk of the major coronary artery and primary branches toward the capillary vessels. This study represents the first, most extensive validated analysis of Womersley-type pulse wave transmission in the entire coronary arterial tree down to the first segment of capillaries. The present model will serve to quantitatively test various hypotheses in the coronary circulation under pulsatile flow conditions.
Huo
Yunlong
Y
Department of Biomedical Engineering, University of California, Irvine, USA.
Kassab
Ghassan S
GS
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology; D005583:Fourier Analysis; D006439:Hemodynamics / Q000502:physiology; D008833:Microcirculation / Q000502:physiology; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D011673:Pulsatile Flow / Q000502:physiology*; D013552:Swine; D014655:Vascular Resistance / Q000502:physiology