title: The use of acetic acid in magnification chromocolonoscopy for pit pattern analysis of small polyps.
abstract: OBJECTIVE
  The role of acetic acid spray during magnification chromocolonoscopy has not previously been evaluated. We aimed to compare the accuracy of predicting polyp histology at magnification colonoscopy, using acetic acid and indigo carmine, either alone or in combination.
  
  
  METHODS
  A total of 46 consecutive patients with polyps detected during colonoscopy which measured 10 mm or less were alternately divided into two groups. In group A patients, 1.5 % acetic acid was applied to the mucosa first, followed by indigo carmine spray; in group B patients, the order was reversed. The pit pattern was assessed after application, in real time. All the lesions were resected and examined histologically.
  
  
  RESULTS
  Altogether, 37 adenomas and 36 hyperplastic polyps were evaluated. In group A, the diagnostic accuracy after spraying with acetic acid was 95 %, which increased to 98 % after application of indigo carmine. In group B, the accuracy after indigo carmine application was 83 %. After subsequent spraying with acetic acid, images were enhanced in 70 % of patients, with an increase in accuracy to 97 %. The mean time required to obtain an initial clear image with the first dye was 14 seconds for both groups.
  
  
  CONCLUSIONS
  This is the first description of the use of acetic acid for pit pattern analysis of colonic polyps. Its ease of use, low cost, and safety, together with its excellent accuracy in the assessment of polyp pit patterns suggest that this method could easily be applied to routine magnification colonoscopy.
authors.affiliation: Department of Gastroenterology and Hepatology and Anatomical Pathology, Royal Brisbane and Women's Hospital, Brisbane, Australia. ktogashi@jichi.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Togashi
authors.forename: D G
authors.initials: DG
authors.lastname: Hewett
authors.forename: D A
authors.initials: DA
authors.lastname: Whitaker
authors.forename: G E
authors.initials: GE
authors.lastname: Hume
authors.forename: L
authors.initials: L
authors.lastname: Francis
authors.forename: M N
authors.initials: MN
authors.lastname: Appleyard
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage; D000287:Administration, Topical; D003111:Colonic Polyps / Q000175:diagnosis*; D003113:Colonoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000008:administration & dosage*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
chemical_list: D007202:Indicators and Reagents; D019342:Acetic Acid