title: [The effect of antihypertensive drugs on the anaesthetic effect of lidocaine in hypertensive patients who need dental treatment].
abstract: The study evaluated the influence of atenolol/nifedipine on the local anaesthesia with lidocaine in 64 patients with essential arterial hypertension following dietetic regimen and divided in: control group (21 patients), atenolol-treated group (21 patients with atenolol therapy) and nifedipine-treated group (22 patients with nifedipine therapy). Atenolol/nifedipine was administrated three hours before anaesthesia (1.5 mg lidocaine/kg body weight) applied on Spix Spina. The atenolol/nifedipine influence on the anaesthetic intensity was evaluated both by the patient and dentist using scales for the appreciation of pain intensity (Visual Analogue Scale, Numerical Rating Scale) at 0 minutes (before anaesthesia), 5, 10, 20, 30, 60 minutes (moments for the determination of lidocaine plasmatic concentrations). There were no statistically significant differences between the values appreciated by the patient and dentist. Our data demonstrated a significant decrease of pain intensity in patients treated with atenolol/nifedipine. Very good inverse correlation was found between lidocaine concentrations and pain intensity.
authors.affiliation: Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină Dentară, Departamentul de Reabilitare Orală Complexă.
authors.forename: Irina
authors.initials: I
authors.lastname: Grădinaru
authors.forename: Marilena
authors.initials: M
authors.lastname: Grădinaru
authors.forename: Cristina Mihaela
authors.initials: CM
authors.lastname: Ghiciuc
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: Monica
authors.initials: M
authors.lastname: Tatarciuc
authors.forename: G
authors.initials: G
authors.lastname: Dimitriu
authors.forename: A
authors.initials: A
authors.lastname: Doloca
mesh_terms: D000766:Anesthesia, Dental / Q000379:methods; D000779:Anesthetics, Local / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D016022:Case-Control Studies; D003729:Dental Care; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008012:Lidocaine / Q000627:therapeutic use*; D009543:Nifedipine / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000779:Anesthetics, Local; D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D001262:Atenolol; D008012:Lidocaine; D009543:Nifedipine