title: Administration of antibody to the lung protects mice against pneumonic plague.
abstract: Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.
authors.affiliation: Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom. jhill@dstl.gov.uk
authors.forename: Jim
authors.initials: J
authors.lastname: Hill
authors.forename: Jim E
authors.initials: JE
authors.lastname: Eyles
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Elvin
authors.forename: Gareth D
authors.initials: GD
authors.lastname: Healey
authors.forename: Roman A
authors.initials: RA
authors.lastname: Lukaszewski
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
mesh_terms: D000336:Aerosols; D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010930:Plague / Q000517:prevention & control*; D052899:Pore Forming Cytotoxic Proteins; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D000336:Aerosols; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C043908:LcrV protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins; C086725:caf1 protein, Yersinia pestis