title: The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma.
abstract: OBJECTIVE
  Expression of thyroid peroxidase (TPO) in the thyroid gland tissue is well known as a sensitive marker of the thyroid malignancy. We have evaluated immunohistochemical assay of TPO for distinguishing follicular thyroid carcinoma from follicular adenoma.
  
  
  METHODS
  Sections of formalin-fixed tissues obtained from 92 patients with thyroid tumors (52 follicular carcinomas and 40 follicular adenomas including the Hurthle cell type) were analyzed using a monoclonal antibody (TPO mAb 47) and the avidin-biotin peroxidase complex immunohistochemical technique. Lesions with staining of more than 80% of the follicular cells/specimen were considered benign, while less than 80% were considered malignant.
  
  
  RESULTS
  TPO immunostaining correlated with the histopathological diagnosis in 24/40 cases of follicular adenomas and 41/52 cases of follicular carcinomas, giving a specificity of 60% and a sensitivity of 79%.
  
  
  CONCLUSIONS
  These results suggest that immunohistochemical assay of TPO expression has limited value for the differential diagnosis of follicular thyroid carcinoma from thyroid follicular adenoma.
authors.affiliation: Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Zemun. ssavin@inep.co.yu
authors.forename: S
authors.initials: S
authors.lastname: Savin
authors.forename: D
authors.initials: D
authors.lastname: Cvejic
authors.forename: T
authors.initials: T
authors.lastname: Isic
authors.forename: I
authors.initials: I
authors.lastname: Paunovic
authors.forename: S
authors.initials: S
authors.lastname: Tatic
authors.forename: M
authors.initials: M
authors.lastname: Havelka
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D000236:Adenoma / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007453:Iodide Peroxidase / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D007453:Iodide Peroxidase