A model for predicting age at menopause in white women.
OBJECTIVE
To develop a model to predict the age at natural menopause and the risk for premenopausal hysterectomy.


METHODS
Cross-sectional study.


METHODS
Multicenter study.


METHODS
A total of 1,345 white women.


METHODS
Ten single nucleotide polymorphisms (SNPs) of seven estrogen (E)-metabolizing genes (i.e., catechol-O-methyltransferase, 17-beta-hydroxysteroid dehydrogenase type 1, cytochrome P-450 [CYP] 17, CYP1A1, CYP1B1, CYP19, and E receptor [ER] alpha) were analyzed by sequencing-on-chip-technology.


METHODS
Patients' reproductive and medical histories were ascertained and correlated to genotypes.


RESULTS
The model incorporates the number of full term pregnancies, the body mass index (BMI), a history of breast surgery, and the presence of CYP17 and CYP1B1-4 polymorphisms as well as the BMI to predict age at natural menopause and the risk for undergoing premenopausal hysterectomy.


CONCLUSIONS
We present the first model to date, which can predict age at natural menopause and the risk for undergoing premenopausal hysterectomy based on genotype information and personal history.
Hefler
Lukas A
LA
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. lukas.hefler@meduniwien.ac.at
Grimm
Christoph
C
Bentz
Eva-Katrin
EK
Reinthaller
Alexander
A
Heinze
Georg
G
Tempfer
Clemens B
CB
D000375:Aging / Q000502:physiology*; D001189:Aryl Hydrocarbon Hydroxylases; D015992:Body Mass Index; D001940:Breast / Q000601:surgery; D003430:Cross-Sectional Studies; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007044:Hysterectomy; D016014:Linear Models; D008499:Medical Records; D008593:Menopause; D008954:Models, Biological; D010298:Parity; D011110:Polymorphism, Genetic; D011247:Pregnancy; D017697:Premenopause; D018570:Risk Assessment; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics
D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1; D013254:Steroid 17-alpha-Hydroxylase