title: The effect of desmopressin, a vasopressin analog, on endurance performance during a prolonged run in simulated heat conditions.
abstract: Arginine vasopressin (AVP) release into the bloodstream is essential for water balance in the body and, thus, for core-temperature regulation. We investigated the effect of the AVP analog desmopressin (Des) on the performance of 6 endurance runners in a simulated heat condition. Four strenuous treadmill runs were performed at a 1-week interval. Over the 4 test sessions, room temperature and relative humidity were 22 +/- 0.4 degrees C and 47% +/- 7%, respectively. Each run included 40 min at 60% maximal aerobic velocity immediately followed by an incremental run until exhaustion. Dehydration and hyperthermia were induced by wearing an impermeable tracksuit. Two runs were performed with no hydration (NH; NH-Des) and two under false hydration (FH; FH-Des). Under FH conditions, the runner was given a set amount of water every 5 min of the run, which was kept in the mouth for 10 s and spat out. Under NH-Des and FH-Des conditions, the run was performed 60 min after a 30 microg intranasal administration of desmopressin. In the NH-Des trial, the total distance run was 5%-8% longer than in the other conditions (p < 0.05). This was associated with a lower heart rate after the 40 min run than occurred in the NH and FH trials (p < 0.01) and a lower tympanic temperature than in the FH trial (p < 0.05). Urine mass was also lower under NH-Des conditions than under NH and FH conditions (p < 0.05). It is suggested that desmopressin administration could improve dramatically prolonged running performances in a hot and humid environment.
authors.affiliation: Institut Supérieur du Sport et de l'Education Physique, Sfax, Tunisie. ftaiti_foued@yahoo.fr
authors.forename: Foued
authors.initials: F
authors.lastname: Ftaiti
authors.forename: Marie Pière
authors.initials: MP
authors.lastname: Dantin
authors.forename: Caroline
authors.initials: C
authors.lastname: Nicol
authors.forename: Christian
authors.initials: C
authors.lastname: Brunet
authors.forename: Laurent
authors.initials: L
authors.lastname: Grélot
mesh_terms: D000328:Adult; D050034:Antidiuretic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking / Q000502:physiology; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D018882:Heat Stress Disorders / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D012420:Running / Q000502:physiology
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin