title: Levels of P34H, a sperm protein of epididymal origin, as a predictor of conventional in vitro fertilization outcome.
abstract: A prospective double-blind study was performed to determine if Western blot detection of P34H, a sperm protein of epididymal origin that is involved in the binding to the zona pellucida, is predictive of standard IVF outcome. Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001).
authors.affiliation: Centre de Recherche en Biologie de la Reproduction, Département d'Obstétrique Gynécologie, Faculté de Médecine, Université Laval, Ste-Foy, Québec, Canada. robert.sullivan@crchul.ulaval.ca
authors.forename: Robert
authors.initials: R
authors.lastname: Sullivan
authors.forename: Christine
authors.initials: C
authors.lastname: Légaré
authors.forename: Marc
authors.initials: M
authors.lastname: Villeneuve
authors.forename: Bernard
authors.initials: B
authors.lastname: Foliguet
authors.forename: François
authors.initials: F
authors.lastname: Bissonnette
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro; D005602:France / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D011792:Quebec / Q000453:epidemiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013401:Sugar Alcohol Dehydrogenases; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D011506:Proteins; D013401:Sugar Alcohol Dehydrogenases; C023300:L-xylulose reductase