[Membrane-selective electrodes for drug analysis. Note II].
Seven membrane-selective electrodes with PVC matrix and liquid-membrane for N-butylscopolamine with different electroactive materials are presented. These electrodes have a linear response in the concentration range of 10(-6) - 10(-2) M N-butylscopolamine bromide, with a detection limit between 4.58 x 10(-7)M and 1.09 x 10(-6)M. These electrodes were used with good results for quantitative assay by direct potentiometry and potentiometric titration of N-butylscopolamine bromide from pharmaceutical formulations. Recovery was between 95.50% and 99.20% for N-butylscopolamine bromide of injectable solutions.
Bibire
Nela
N
Universitatea de Medicină gi Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.
Dorneanu
V
V
D000465:Algorithms; D002086:Butylscopolammonium Bromide / Q000032:analysis*; D004867:Equipment Design; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D008567:Membranes, Artificial; D018727:Muscarinic Antagonists / Q000032:analysis*; D011143:Polyvinyl Chloride; D011199:Potentiometry / Q000295:instrumentation / Q000706:statistics & numerical data; D012996:Solutions
D008567:Membranes, Artificial; D018727:Muscarinic Antagonists; D012996:Solutions; D002086:Butylscopolammonium Bromide; D011143:Polyvinyl Chloride