title: Effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction.
abstract: OBJECTIVE
  We estimated the effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction.
  
  
  METHODS
  The target population consisted of men 50, 60 or 70 years old residing in the study area in Finland in 1994. Questionnaires were mailed to 3,143 men in 1994 and to 2,864 men 5 years later. The followup sample consisted of 1,683 men who responded to baseline and followup questionnaires. We estimated the effect of NSAIDs on the incidence of ED in men free from moderate or complete ED at baseline (in 1,126). ED was assessed by 2 questions on subject ability to achieve or maintain an erection sufficient for intercourse. Confounding was assessed by stratification and by adjustment in multivariate Poisson regression model.
  
  
  RESULTS
  The incidence of ED was 93 cases per 1,000 person-years in men who used and 35 in those who did not use NSAIDs. Among men with arthritis, the most common indication for NSAID use, ED incidence was 97 cases per 1,000 in those using and 52 in men who did not use NSAIDs. Compared with men who did not use NSAIDs and were free from arthritis, the relative risk of ED after controlling for the effects of age, smoking, and other medical conditions and medications was higher in men who used NSAIDs but were free of arthritis (IDR 2.0, 95% CI 1.2-3.5) and in those who used NSAIDs and had arthritis (IDR 1.9, 95% CI 1.2-3.1). The relative risk was only somewhat higher in men who had arthritis but did not use NSAIDs (IDR 1.3, 95% CI 0.9-1.8).
  
  
  CONCLUSIONS
  The use of nonsteroidal anti-inflammatory drugs increases the risk of ED and the effect is independent of indication.
authors.affiliation: Tampere School of Public Health, University of Tampere, Tampere, Finland. r_shiri@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Shiri
authors.forename: J
authors.initials: J
authors.lastname: Koskimäki
authors.forename: J
authors.initials: J
authors.lastname: Häkkinen
authors.forename: T L J
authors.initials: TL
authors.lastname: Tammela
authors.forename: A
authors.initials: A
authors.lastname: Auvinen
authors.forename: M
authors.initials: M
authors.lastname: Hakama
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007172:Erectile Dysfunction / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal