A fungicidal monoclonal antibody protects against murine invasive candidiasis.
Mice infected by Candida albicans and treated with monoclonal antibody C7 survived longer than saline-treated animals. A prozone-like effect was observed. The in vitro candidacidal activity of macrophages was strongly enhanced when C. albicans was opsonized by C7 and complete murine serum was present.
Sevilla
María J
MJ
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Apartado 644, E-48080 Bilbao, Vizcaya, Spain. mariajesus.sevilla@ehu.es
Robledo
Beatriz
B
Rementeria
Aitor
A
Moragues
María D
MD
Pontón
José
J
D000818:Animals; D000908:Antibodies, Fungal / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000517:prevention & control*; D005260:Female; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal