title: Treatment of central pontine myelinolysis with thyrotropin-releasing hormone.
abstract: BACKGROUND
  Central pontine myelinolysis (CPM), demyelination of the brain stem, is a brain injury apparently due to osmotic forces. There is no consensus for its treatment.
  
  
  METHODS
  We describe here a case of CPM that occurred in a young patient after correction of hyponatremia, its treatment by intravenous thyrotropin-releasing hormone, and its outcome.
  
  
  CONCLUSIONS
  Although very few instances of thyrotropin-releasing hormone treatment for CPM have been described, it appears to be effective and well tolerated. Studies are needed to assess its real efficacy.
authors.affiliation: Internal Medicine Department, Saint-Joseph Hospital and Medical Center, Saint-Joseph University, Beirut, Lebanon.
authors.forename: Emile F
authors.initials: EF
authors.lastname: Zein
authors.forename: Souheil E
authors.initials: SE
authors.lastname: Karaa
authors.forename: Florence
authors.initials: F
authors.lastname: Rollot
authors.forename: Philippe
authors.initials: P
authors.lastname: Blanche
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Chemaly
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000188:drug therapy* / Q000473:pathology*; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013973:Thyrotropin-Releasing Hormone