Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreas.
OBJECTIVE
To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT.


METHODS
We analyzed the expression of p53 protein, proliferating cell nuclear antigen, alpha6-integrin subunit, alpha5beta1-integrin, and interleukin-1 receptor type I in tumor specimens from eight patients with MCT.


RESULTS
The tumors were classified as mucinous cyst adenoma (n=6) or mucinous cyst adenocarcinoma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha6-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha6-integrin subunit and p53 protein were also co-expressed.


CONCLUSIONS
Our present results indicate that coexpression of the alpha6-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.
Sawai
Hirozumi
H
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan. cb8h-swi@asahi-net.or.jp
Okada
Yiuji
Y
Funahashi
Hitoshi
H
Matsuo
Yoichi
Y
Hayakawa
Tetsushi
T
Tanaka
Moritsugu
M
Takeyama
Hiromitsu
H
Manabe
Tadao
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018282:Cystadenocarcinoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D039503:Integrin alpha6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D053573:Receptors, Interleukin-1 Type I; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D039081:Integrin alpha5beta1; D039503:Integrin alpha6; D018809:Proliferating Cell Nuclear Antigen; D017472:Receptors, Interleukin-1; D053573:Receptors, Interleukin-1 Type I; D016159:Tumor Suppressor Protein p53