title: Blood volume and haemoglobin oxygen content changes in human bone marrow during orthostatic stress.
abstract: The interest in, and the need for effective measures to be used in screening, diagnosis, and the follow-up of skeletal pathologies is growing markedly. This paper proposes a completely new and non-invasive technique allowing the study of the human tibia bone marrow (BM) haemodynamics with a time resolution of 1 s. The technique, based on near infrared spectroscopy, is sensitive enough to allow the detection of BM blood volume and/or oxygen saturation changes during orthostatic variations imposed by a tilt bed. An increase in the slope of the bed of 15 degrees is sufficient to detect this phenomenon. The ability to study the possible presence of a neural control of BM haemodynamics is also discussed. No other existing technique currently allows one to obtain the proposed results and this approach might open up a new field of study related to human BM physiology.
authors.affiliation: Département de Neurosciences Fondamentales, University of Geneva, Switzerland. Tiziano.Binzoni@medecine.unige.ch
authors.forename: Tiziano
authors.initials: T
authors.lastname: Binzoni
authors.forename: Terence S
authors.initials: TS
authors.lastname: Leung
authors.forename: Celine
authors.initials: C
authors.lastname: Courvoisier
authors.forename: Remo
authors.initials: R
authors.lastname: Giust
authors.forename: Gilbert
authors.initials: G
authors.lastname: Tribillon
authors.forename: Tijani
authors.initials: T
authors.lastname: Gharbi
authors.forename: David T
authors.initials: DT
authors.lastname: Delpy
mesh_terms: D000328:Adult; D001810:Blood Volume; D001853:Bone Marrow / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000378:metabolism* / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology
chemical_list: D006454:Hemoglobins; D010100:Oxygen