title: [Clinical study on effect of fluoxetine combined with Chinese medicine or tibetan drugs in treating senile depression in plateau district].
abstract: OBJECTIVE
  To compare the ettect and side-ettect of fluoxetine and combination of fluoxetine and Chinese or Tibetan medicine in treating senile depression in plateau district. Methods Ninety patients with diagnosis of senile depression conformed to CCMD-3 standard, in plateau district of 2260 - 3200 m altitude were randomly divided into three groups and treated with fluoxetine (group A), fluoxetine plus Sanpu Xinnao Xin granule (group B) and fluoxetine plus Xiaoyao pill (group C), respectively, 30 cases in each group. Therapeutic effects were evaluated with Hamilton' s depressive scale (HAMD) and treatment emergent symptom scale (TESS) after 6 weeks treatment.
  
  
  RESULTS
  There was no significant difference in the therapeutic effects between the three groups. The adverse reaction in Group B and C was less than that in Group A (P<0.01). Conclusion Sanpu Xinnao Xin granule and Xiaoyao pill can raise the tolerance of patients with senile depression in plateau area against the adverse reaction of fluoxetine.
authors.affiliation: The Affiliated Hospital of Qinghai University, Xining. qyfyxhn@163.com
authors.forename: Hong-Wu
authors.initials: HW
authors.lastname: Zhang
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Wang
authors.forename: Hui-Ning
authors.initials: HN
authors.lastname: Xu
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhao
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Dai
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Xinbai
authors.initials: X
authors.lastname: Du
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Song
authors.forename: Guoling
authors.initials: G
authors.lastname: Han
authors.forename: Guilan
authors.initials: G
authors.lastname: Liu
authors.forename: Pingshan
authors.initials: P
authors.lastname: Li
authors.forename: Huahua
authors.initials: H
authors.lastname: Lin
mesh_terms: D000368:Aged; D000531:Altitude; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D004365:Drugs, Chinese Herbal; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors