title: Classification and treatment of sub-threshold depression.
abstract: OBJECTIVE
  The purpose of this review is to evaluate the recent literature on depressive spectrum disorders.
  
  
  RESULTS
  Research into so-called 'minor' forms of depression has moved beyond efforts justifying these entities and describing their components to an exploration of the impact of depressive spectrum disorders on health, quality of life, and as a predisposing factor for major depressive disorder. As with major depression, pharmacological and psychosocial interventions may be useful treatments. Researchers have begun to examine the nature of depressive spectrum disorders in specific populations, such as the elderly and the medically ill.
  
  
  CONCLUSIONS
  Sub-threshold forms of depression are becoming a focus of research at a time when quality of life and prevention of serious mental illness are being recognized as important public health concerns. Individuals with depressive spectrum disorders are at an increased risk of developing major depressive disorder and are more likely to have a history of episodes of depression. The challenges confronting psychiatric researchers include developing a consensus about diagnosis of depressive spectrum disorders and ways to measure their severity, and increasing public recognition of the impact of the entire spectrum of depression in order to facilitate the discovery of appropriate treatments.
authors.affiliation: Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90048, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Rowe
authors.forename: Mark Hyman
authors.initials: MH
authors.lastname: Rapaport
mesh_terms: D003866:Depressive Disorder / Q000145:classification* / Q000175:diagnosis* / Q000628:therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D011613:Psychotherapy / Q000379:methods