title: The human FK506-binding proteins: characterization of human FKBP19.
abstract: Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway. There are distinct differences in tissue distribution and expression levels of each variant. In this article we describe the characterization of human FKBP19 (Entrez Gene ID: FKBP11), an FK506-binding protein predominantly expressed in vertebrate secretory tissues. The FKBP19 sequence comprises a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12. This domain binds FK506 weakly in vitro. FKBP19 mRNA is abundant in human pancreas and other secretory tissues and high levels of FKBP19 protein are detected in the acinar cells of mouse pancreas.
authors.affiliation: Trafford Centre for Graduate Medical Education and Research, University of Sussex, Falmer, Brighton, BN1 9QG, UK. s.l.rulten@sussex.ac.uk
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Rulten
authors.forename: Ross A
authors.initials: RA
authors.lastname: Kinloch
authors.forename: Hilda
authors.initials: H
authors.lastname: Tateossian
authors.forename: Colin
authors.initials: C
authors.lastname: Robinson
authors.forename: Lucy
authors.initials: L
authors.lastname: Gettins
authors.forename: John E
authors.initials: JE
authors.lastname: Kay
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D015153:Blotting, Western; D002417:Cattle; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D007166:Immunosuppressive Agents / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011994:Recombinant Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D016559:Tacrolimus / Q000378:metabolism; D022061:Tacrolimus Binding Protein 1A / Q000378:metabolism; D022021:Tacrolimus Binding Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C511900:FKBP11 protein, human; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D022061:Tacrolimus Binding Protein 1A; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus