Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions.
The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.
Adighibe
O
O
Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, 35 Convent Drive, Bethesda, MD 20892, USA.
Micklem
K
K
Campo
L
L
Ferguson
M
M
Harris
A
A
Pozos
R
R
Gatter
K
K
Pezzella
F
F
D018952:Antigens, CD34 / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D021621:Imaging, Three-Dimensional; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D009389:Neovascularization, Pathologic; D013194:Staining and Labeling
D018952:Antigens, CD34; D007633:Keratins