title: Hypotheses on the effect of cadmium on glutathione content of red blood corpuscles.
abstract: Previous studies have shown that Glutathione, a tripeptide found in blood, is involved in protecting against toxins. Glutathione levels are known to drop in response to cadmium. Using 15 twin pairs, we modeled the effect of cadmium on glutathione levels. The heritability of glutathione content was 91%. The application of cadmium significantly reduced the mean level of GSH. However, this reduction in GSH was not due to additive genetic influences in our sample.
authors.affiliation: Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. sri.shekar@qimr.edu.au
authors.forename: Sri Niranjan
authors.initials: SN
authors.lastname: Shekar
authors.forename: Tathagata
authors.initials: T
authors.lastname: Banerjee
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
mesh_terms: D000293:Adolescent; D000328:Adult; D002104:Cadmium / Q000494:pharmacology*; D016009:Chi-Square Distribution; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005978:Glutathione / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D016013:Likelihood Functions; D008297:Male
chemical_list: D002104:Cadmium; D005978:Glutathione