title: Release of vasopressin during suppression of oestrous cycle in rat by zoladex and hypovolemic challenge.
abstract: BACKGROUND
  The vasopressin (AVP) response to hypovolemia has been compared in intact and chemically castrated rats. This functional ovariectomy was done to confirm the findings in surgical ovariectomy of how gonadal steroids modulate the release of AVP under hypo-volemic challenge.
  
  
  METHODS
  Twenty female Sprague Dawley rats were checked for oestrous over two consecutive cycles. The ten control rats were given sub-cutaneous puncture only whereas the experimental were given Zoladex implant. On the fifteenth day all the rats were given intra-peitoneal injection of poly-ehylene glycol. All the rats were de-capitated after an hour.
  
  
  RESULTS
  The uterine weight was significantly decreased in experimental group. The plasma AVP level was also significantly decreased in the experimental group. The pituitary AVP level was significantly increased in the experimental group.
  
  
  CONCLUSIONS
  The chemical castration effected the AVP secretion, this proves that the sex steroids modulate the release of AVP secretion inspite of hypo-volemic challenge.
authors.affiliation: Department of Physiology, Ayub Medical College Abbottabad. salmakundi@hotmail.com
authors.forename: Salma Aslam
authors.initials: SA
authors.lastname: Kundi
authors.forename: Saleem
authors.initials: S
authors.lastname: Wazir
authors.forename: Saleem
authors.initials: S
authors.lastname: Afzal
authors.forename: Naeema
authors.initials: N
authors.lastname: Afzal
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Qayum
authors.forename: Mary L
authors.initials: ML
authors.lastname: Forsling
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects / Q000378:metabolism; D005260:Female; D017273:Goserelin / Q000494:pharmacology*; D020896:Hypovolemia / Q000378:metabolism*; D010052:Ovariectomy / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects; D014667:Vasopressins / Q000187:drug effects* / Q000378:metabolism
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D014667:Vasopressins