title: Using of electrochemical methods for studying of metallothionein content in the human blood serum of a patient poisoned by lead and treated by platinum.
abstract: Metallothioneins belong to the group of intracellular, high molecular and cysteine-rich proteins whose content increase with increasing concentration of a heavy metal. Here we applied the adsorptive transfer stripping differential pulse voltammetry Brdicka reaction for the determination of metallothionein in human blood serum of patient poisoned by lead and/or treated by platinum. The increased metallothionein concentrations in both cases were observed.
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University of Agriculture and Forestry, Zemedelská 1, Brno, CZ-613 00, Czech Republic. kizek@sci.muni.cz.
authors.forename: Jitka
authors.initials: J
authors.lastname: Petrlová
authors.forename: Ondrej
authors.initials: O
authors.lastname: Blastík
authors.forename: Richard
authors.initials: R
authors.lastname: Průsa
authors.forename: Jirí
authors.initials: J
authors.lastname: Kukacka
authors.forename: David
authors.initials: D
authors.lastname: Potĕsil
authors.forename: Radka
authors.initials: R
authors.lastname: Mikelová
authors.forename: Vojtĕch
authors.initials: V
authors.lastname: Adam
authors.forename: Josef
authors.initials: J
authors.lastname: Zehnálek
authors.forename: René
authors.initials: R
authors.lastname: Kizek
mesh_terms: D002648:Child; D004563:Electrochemistry / Q000379:methods; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000097:blood*; D008668:Metallothionein / Q000097:blood*; D017671:Platinum Compounds / Q000627:therapeutic use*
chemical_list: D017671:Platinum Compounds; D008668:Metallothionein