Nogo-66 receptor at the gap junctions between pituicytes of the rat.
Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior pituitary, which is densely packed with pituicytes, a special type of astrocyte, and is known to be rich in gap junctions. We were able to demonstrate with immunohistochemistry and immuno-electron microscopy abundant Nogo-66 receptor immunoreactive gap junctions between pituicytes. This study, together with our prior one, strongly suggests that the Nogo-66 receptor may play a role in regulating the function of the gap junctions.
Wang
Ya-Zhou
YZ
Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China.
Liu
Ying-Ying
YY
Liu
Jin-Ping
JP
You
Si-Wei
SW
Ju
Gong
G
D000818:Animals; D015153:Blotting, Western / Q000379:methods; D018031:Connexin 43 / Q000378:metabolism; D058851:GPI-Linked Proteins; D017629:Gap Junctions / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry / Q000379:methods; D016253:Microscopy, Immunoelectron / Q000379:methods; D009185:Myelin Proteins / Q000378:metabolism*; D000070816:Nogo Receptor 1; D010904:Pituitary Gland, Posterior / Q000166:cytology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D018031:Connexin 43; D058851:GPI-Linked Proteins; D009185:Myelin Proteins; D000070816:Nogo Receptor 1; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C486581:Rtn4r protein, rat