title: [Secular trend of nosocomial pneumonia in an university hospital in Zhengzhou].
abstract: OBJECTIVE
  To investigate the secular trend of infection rate, risk factor exposure rates for nosocomial pneumonia (NP), and to evaluate the nosocomial infection surveillance and control programs efficacy in an university hospital from 1993 to 2000.
  
  
  METHODS
  All 126 665 hospitalized patients from 1993 to 2000 were studied for NP. The independent risk factors for NP were analyzed by using case-control study method and logistic regression technique. The time-specific rates for NP and risk factor exposure were calculated annually.
  
  
  RESULTS
  The infection rates for NP were decreased by 50% from 1.20% in 1993 to 0.60% in 2000. The logistic regression analysis showed that the independent risk factors for NP were immunosuppressive therapy (OR = 2.72), chemotherapy (OR = 2.17), cancer (OR = 1.45), chronic obstructive pulmonary disease (COPD, OR = 1.88), ICU (OR = 3.18), coma (OR = 3.26), tracheotomy (OR = 14.95), hemodialysis (OR = 5.12), bone or lumbar puncture (OR = 1.82). The time-trends for exposure rates of COPD and bone or lumbar puncture were slightly decreased, however those for the others and the synthetic risk factors were not changed significantly.
  
  
  CONCLUSIONS
  The infection rates for NP were significantly decreased in the case of no change for exposure rates of risk factors for NP, this suggests that the nosocomial infection surveillance and control programs were effective for lowering infection rate for NP in this hospital.
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Henan 450052, China.
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Hu
authors.forename: Qiu-ping
authors.initials: QP
authors.lastname: Fan
authors.forename: Hua-yan
authors.initials: HY
authors.lastname: Xing
authors.forename: Hui-qin
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Yuan-lin
authors.initials: YL
authors.lastname: Xi
authors.forename: Mei-xi
authors.initials: MX
authors.lastname: Zhang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D017053:Infection Control / Q000379:methods; D007297:Inpatients / Q000706:statistics & numerical data; D011446:Prospective Studies; D015203:Reproducibility of Results; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013997:Time Factors