[Acute coronary syndrome related factors].
Dysruption of vulnerable plaque is a major cause of acute coronary syndromes, including acute myocardial infarction and unstable angina. Therefore, plaque vulnerability has been important role in the pathogenesis of acute cardiovascular events. Recent studies have reported the mechanisms responsible for plaque rupture and erosion leading to acute thrombosis in the histologic, cellular, and molecular levels. A basic approach to atherosclerotic diseases is important and helpful for physicians in clinical situation. In this article, we review related factors leading to plaque rupture and erosion in the basic aspect.
Koga
Hidenobu
H
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University.
Sugiyama
Seigo
S
Ogawa
Hisao
H
D000789:Angina, Unstable / Q000209:etiology; D017209:Apoptosis; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology; D003328:Coronary Thrombosis / Q000209:etiology; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications; D018836:Inflammation Mediators / Q000502:physiology; D008077:Lipoproteins, LDL; D008262:Macrophage Activation; D020782:Matrix Metalloproteinases / Q000502:physiology; D009203:Myocardial Infarction / Q000209:etiology; D018384:Oxidative Stress; D013577:Syndrome
D018836:Inflammation Mediators; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D020782:Matrix Metalloproteinases