title: Collagenase in cranial morphogenesis.
abstract: Collagen is the most abundant extracellular matrix protein in connective tissues of higher animals. The growth of connective tissues is intimately linked to the ability to model and remodel the collagen-rich matrices of the organism at critical points during development and growth to allow expansion and adaptation of tissue interfaces. The mammalian cranium is one such place where collagen remodeling is required for proper growth, and this review explores the consequences of abrogated collagen remodeling as they materialize in a mouse model deficient for the membrane type 1 matrix metalloproteinase.
authors.affiliation: Craniofacial and Skeletal Diseases Branch, Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. kenn.holmbeck@nih.gov
authors.forename: Kenn
authors.initials: K
authors.lastname: Holmbeck
mesh_terms: D000818:Animals; D002356:Cartilage / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000235:genetics / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009024:Morphogenesis; D012886:Skull / Q000201:enzymology* / Q000254:growth & development*; D014078:Tooth Eruption
chemical_list: D003094:Collagen; D017364:Collagenases; D020782:Matrix Metalloproteinases