title: [Pancreatic acinar cell carcinoma successfully treated with combination of oral TS-1 and intra-arterial cisplatin].
abstract: Pancreatic acinar cell carcinomas are rare, and little is reported on their chemotherapy. We report a 49-year old male patient with pancreatic acinar cell carcinoma and multiple liver metastases, which responded to oral TS-1 and hepatic arterial infusion of cisplatin. The patient underwent a partial hepatectomy, MCT abrasions and excision of the pancreatic tumor. Postoperative pathological studies revealed metastases of acinar cell carcinoma to the liver and lymph nodes; the primary lesion was undetermined. After surgery, the patient was treated with hepatic arterial infusion of cisplatin and oral TS-1. Metastatic tumors completely disappeared, and serum lipase decreased to normal levels. Abdominal CT one year after surgery revealed a pancreatic body tumor, which was surgically removed. Pathological studies showed primary pancreatic acinar cell carcinoma, while previous metastases remained under control. To summarize, TS-1 and cisplatin can be effective treatments for pancreatic acinar cell carcinomas.
authors.affiliation: Dept. of Cardiovascular and Digestive Surgery, Shimane University School of Medicine.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kataoka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nio
authors.forename: Seiji
authors.initials: S
authors.lastname: Yano
authors.forename: Makoto
authors.initials: M
authors.lastname: Koike
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Itakura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Itagaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Endo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higami
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018267:Carcinoma, Acinar Cell / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011725:Pyridines / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin