Plasmodium vinckei: selection of a strain exhibiting stable resistance to arteether.
A strain of rodent malaria parasite Plasmodium vinckei showing >12-fold resistance to arteether has been selected after exposure to sub-curative doses of drug in 44 sequential passages over a period of 700 days. Experimentally induced resistance was found to be stable after drug free maintenance of parasites for 11 serial passages over a period of 100 days. Cross-sensitivity studies have shown that apart form resistance to related derivatives like artemether and artesunic acid, the derived parasites also show resistance to quinine and mefloquine.
Puri
S K
SK
Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India.
Chandra
Ramesh
R
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D037621:Artemisinins / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D051379:Mice; D021261:Parasitic Sensitivity Tests; D010961:Plasmodium / Q000145:classification / Q000187:drug effects*; D012692:Serial Passage
D000962:Antimalarials; D037621:Artemisinins; C055141:artemotil