title: Clinical and pathological characteristics of patients presenting with biochemical progression after radical retropubic prostatectomy for pathologically organ-confined prostate cancer.
abstract: BACKGROUND
  To identify risk factors for biochemical failure after radical prostatectomy (RP) in men with pathologically organ-confined (OC) prostate cancer (PCa).
  
  
  METHODS
  Clinical and pathological features of 350 consecutive patients with pathologically OC PCa treated only with RP and bilateral pelvic lymphadenectomy were analyzed, retrospectively, to identify predictor parameters of prostate-specific antigen (PSA) failure (PSA>or=0.4 ng/ml). The median follow-up was 58.6 months (range: 3.9-183 months). All pathological specimens were step sectioned at 4-mm intervals. Kaplan-Meier progression-free survival rates and chi2 test were adopted for statistical analyses. Multivariate Cox proportional hazard regression models were used to test the association between pathological Gleason score and surgical margin status.
  
  
  RESULTS
  67 patients (19.1%) failed at a median follow-up of 40.2 months (range 1.9-123.3). Age and preoperative PSA failed to reveal significance also in patients with serum PSA>or=20 ng/ml (p=0.46). Patients with T3 clinical stage had a higher progression rate compared to T1C and T2 (43.5 vs. 27.8 and 17.3%, respectively) even if no high statistical significance was pointed out. Presence of perineural infiltration (p=0.04) and prostatic apex infiltration (p=0.74) in the prostatectomy specimens failed to reveal significance. A high pathological Gleason score (>or=7; p=0.0003) and surgical margin status (p<0.0001) were shown to be the most powerful predictive parameters of biochemical progression.
  
  
  CONCLUSIONS
  In patients with pathologically OC PCa the presence of a high pathological Gleason score and positive surgical margins appear to represent the most important factors for prediction of outcome following RP.
authors.affiliation: Department of Urology, School of Medicine, Padua, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pinto
authors.forename: T
authors.initials: T
authors.lastname: Prayer-Galetti
authors.forename: M
authors.initials: M
authors.lastname: Gardiman
authors.forename: E
authors.initials: E
authors.lastname: Sacco
authors.forename: M
authors.initials: M
authors.lastname: Ciaccia
authors.forename: S
authors.initials: S
authors.lastname: Fracalanza
authors.forename: G
authors.initials: G
authors.lastname: Betto
authors.forename: F
authors.initials: F
authors.lastname: Pagano
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D017211:Treatment Failure
chemical_list: D017430:Prostate-Specific Antigen