title: Disposition of deracoxib in cats after oral administration.
abstract: The pharmacokinetics of deracoxib in seven healthy cats were determined following a single oral (1 mg/kg) dose. Minimal variability among cats was found for all estimated pharmacokinetic variables. Terminal half-life (t(1/2)) was 7.9 hours. The mean maximum concentration (C(max)) was 0.28 microg/mL and was measured 3.64 hours after drug administration. Deracoxib was not detectable in the plasma after 60 hours. The compounded liquid formula was accepted readily, and no adverse effects were observed. Further studies are needed to determine the efficacy and safety of deracoxib after acute and chronic use in the cat.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-4544, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Gassel
authors.forename: Karen M
authors.initials: KM
authors.lastname: Tobias
authors.forename: Sherry K
authors.initials: SK
authors.lastname: Cox
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002415:Cats / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D013449:Sulfonamides / Q000493:pharmacokinetics*; D013997:Time Factors; D000096926:Benzenesulfonamides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C471996:deracoxib; D000096926:Benzenesulfonamides