title: The impact of detrusor overactivity on bladder function in younger and older women.
abstract: OBJECTIVE
  We examined the relationship of DO and aging, and bladder function in female volunteers.
  
  
  METHODS
  We recruited 85 cognitively competent, fully functional female volunteers who were 22 to 90 years old (median age 54) with and without symptoms suggestive of DO. Comprehensive assessment included a bladder diary, uroflowmetry and videourodynamics. We examined predefined urodynamic and diary variables for associations with DO and age, summarizing results in the 3 subgroups no DO, intermediate DO and clinically relevant DO.
  
  
  RESULTS
  Compared to women without DO those with DO showed a decrease in maximum cystometric capacity (558 vs 448 ml), mean daytime voided volume (260 vs 175 ml) and volume at strong desire to void (363 vs 283 ml) but an increase in maximum isovolumetric pressure (41 vs 64 cm H2O) and maximum detrusor pressure during involuntary contraction (intermediate and relevant DO 22 and 37 cm H2O, respectively). The positive association between increased detrusor contraction strength and DO was present at younger ages but absent in older subjects. Maximum urethral closure pressure and detrusor contraction strength decreased significantly with age.
  
  
  CONCLUSIONS
  From young adulthood to old age DO appears to affect bladder function parameters. It is associated with decreased bladder capacity and increased bladder sensation. Moreover, in younger adults DO is also associated with increased detrusor contraction strength, which is an association not seen in older individuals. This age associated loss of muscle function may be related to sarcopenia, implying that different treatments may be appropriate in older adults.
authors.affiliation: Bethanien-Krankenhaus, Geriatric Center of the University of Heidelberg, Heidelberg, Germany. mpfisterer@bethanien-heidelberg.de
authors.forename: Mathias H-D
authors.initials: MH
authors.lastname: Pfisterer
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Griffiths
authors.forename: Lisa
authors.initials: L
authors.lastname: Rosenberg
authors.forename: Werner
authors.initials: W
authors.lastname: Schaefer
authors.forename: Neil M
authors.initials: NM
authors.lastname: Resnick
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000503:physiopathology*; D014549:Urinary Incontinence / Q000503:physiopathology*; D014563:Urodynamics