Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice.
This study verifies the effects of bovine brain phosphatidylserine (PS) on passive avoidance (PA) and contextual fear conditioning (CFC) tests in scopolamine-treated mice. Mice received daily i.p. 50 mg/kg PS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. On day 6, mice received saline (TRIS-SAL and PS-SAL) or 1 mg/kg SCO (TRIS-SCO and PS-SCO) i.p. After 20 min, the animals were submitted to PA (experiment 1) or CFC (experiment 2) training sessions, and tests were performed 24 h later. Latency in entering the dark chamber of the PA apparatus presented by TRIS-SCO (but not PS-SCO) group in the test was significantly higher than those presented by controls. Except for TRIS-SCO, all the groups presented higher latencies in the test compared to the training session. In experiment 2, the TRIS-SCO (but not PS-SCO) group presented significantly lower freezing duration than that presented by the TRIS-SAL group in the test. Animals treated with PS alone presented higher freezing duration than that presented by the TRIS-SAL group. The results demonstrate that PS attenuates SCO-induced amnesia in both PA and CFC tests. In addition, PS per se improves retention in the CFC test.
Claro
Flavia T
FT
Department of Pharmacology, Universidade Federal de São Paulo, R. Botucatu, 862-Ed Leal Prado, CEP 04023-062, São Paulo, SP, Brazil.
Patti
Camilla L
CL
Abílio
Vanessa C
VC
Frussa-Filho
Roberto
R
Silva
Regina H
RH
D000647:Amnesia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology*; D002417:Cattle; D003213:Conditioning, Psychological / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005239:Fear / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D018727:Muscarinic Antagonists / Q000633:toxicity*; D010718:Phosphatidylserines / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000633:toxicity*
D018727:Muscarinic Antagonists; D010718:Phosphatidylserines; D012601:Scopolamine