Gene therapy for HIV infection: what does it need to make it work?
The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved. This review focuses on the determinants of therapeutic efficacy and discusses the potential and also the limits of current gene therapy approaches for HIV infection.
von Laer
Dorothee
D
Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42, Frankfurt a.M., Germany. laer@em.uni-frankfurt.de
Hasselmann
Susanne
S
Hasselmann
Klaus
K
D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics; D015658:HIV Infections / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000998:Antiviral Agents