Biological response modifiers as adjuncts to stem cell transplantation.
Cytokines produced by immune and non-immune cells serve as potent mediators with the properties of signal cells that coordinate the immune response. They are delivered by cells either to the systemic circulation or to the local environment. They are being used at present in the field of stem cell transplantation (SCT) in order to improve transplant outcome. This paper reviews the existing data on pre-, peri- and post-SCT treatment with cytokines.
Shapira
Michael Y
MY
Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel. shapiram@hadassah.org.il
Resnick
Igor B
IB
Tsirigotis
Panagiotis D
PD
Slavin
Shimon
S
D000818:Animals; D049109:Cell Proliferation; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D006410:Hematopoiesis; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016219:Immunotherapy, Adoptive; D007372:Interferons / Q000494:pharmacology / Q000627:therapeutic use; D007378:Interleukins / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000601:surgery / Q000628:therapy*
D016207:Cytokines; D007155:Immunologic Factors; D007378:Interleukins; D007372:Interferons