[Use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in patients with acute coronary syndrome].
Renin-angiotensin system is well known that it plays an important role in the initiation and amplification of atherosclerosis that lead to cardiovascular disease. Angiotensin II is deeply involved in vasoconstriction, oxidative stress, inflammation, thrombosis, vascular remodeling, and sympathetic nerve activity. Many studies have documented the favorable effects of angiotensin converting enzyme inhibitor(ACE-I) and angiotensin receptor blocker(ARB) on cardiovascular disease in basic and clinical trials. Now accumulated evidences suggest ACE-I and ARB potentially prevent coronary plaque rapture, thrombosis and myocardial remodeling with acute coronary syndrome (ACS). ACS is occurred from plaque rupture on mild to moderate coronary atherosclerosis. Therefore, on treatment of ACS, it is important to prevent the plaque rupture and thrombosis by pharmacological intervention with ACE-I and ARB than coronary artery intervention which is down stream therapy for coronary artery stenosis.
Iino
Kenji
K
The Internal Medicine Cardiology and Respiratory, Akita University School of Medicine.
Ito
Hiroshi
H
D000789:Angina, Unstable / Q000188:drug therapy* / Q000209:etiology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000150:complications / Q000473:pathology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003328:Coronary Thrombosis / Q000150:complications / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000150:complications; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology; D018384:Oxidative Stress; D012084:Renin-Angiotensin System / Q000502:physiology; D013577:Syndrome
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors