Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.
Kainuma
Masahiko
M
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Kasuga
Jun-ichi
J
Hosoda
Shinnosuke
S
Wakabayashi
Ken-ichi
K
Tanatani
Aya
A
Nagasawa
Kazuo
K
Miyachi
Hiroyuki
H
Makishima
Makoto
M
Hashimoto
Yuichi
Y
D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics; D000099150:Receptor, Farnesoid X-Activated
D001559:Benzhydryl Compounds; D004268:DNA-Binding Proteins; D008024:Ligands; D047493:PPAR alpha; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated; C010129:diphenylmethane