Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.
McGirt
Matthew J
MJ
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Woodworth
Graeme F
GF
Pradilla
Gustavo
G
Legnani
Federico
F
Warner
David
D
Tamargo
Rafael
R
Clatterbuck
Richard
R
Lynch
John R
JR
Laskowitz
Daniel T
DT
D000818:Animals; D001363:Awards and Prizes; D001488:Basilar Artery / Q000033:anatomy & histology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011817:Rabbits; D019821:Simvastatin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D020301:Vasospasm, Intracranial / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology
D019821:Simvastatin; D019001:Nitric Oxide Synthase