title: Deep-seated resistance in relapsed paratyphoid fever.
abstract: We describe a case of relapsed paratyphoid fever in which the isolate had reduced susceptibility to ciprofloxacin due to a rare mutation within the gyrA gene. 18fluorodeoxyglucose positron emission tomography scanning identified deep-seated infection including unsuspected aortitis and highlights the utility of novel imaging techniques to improve our understanding and treatment of this disease.
authors.affiliation: Department of Infectious Diseases, Hammersmith Hospital, London, United Kingdom. graham.cooke@st-mary's.nhs.uk
authors.forename: Graham S
authors.initials: GS
authors.lastname: Cooke
authors.forename: Fiona J
authors.initials: FJ
authors.lastname: Cooke
authors.forename: Madeline
authors.initials: M
authors.lastname: Stone
authors.forename: Keith
authors.initials: K
authors.lastname: Turner
authors.forename: Adil
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: Zarni
authors.initials: Z
authors.lastname: Win
authors.forename: John
authors.initials: J
authors.lastname: Wain
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Rogers
authors.forename: Jon S
authors.initials: JS
authors.lastname: Friedland
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: Bamford
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008875:Middle Aged; D010284:Paratyphoid Fever / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D012482:Salmonella paratyphi A / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents