title: Features associated with excessive exercise in women with eating disorders.
abstract: OBJECTIVE
  Excessive exercise and motor restlessness are observed in a substantial number of patients with eating disorders. This trait has been studied extensively among animal models of activity anorexia nervosa (AN) and may hold particular interest as an endophenotype for AN. We explored features associated with excessive exercise across subtypes of eating disorders.
  
  
  METHODS
  Participants were female probands and affected female relatives from the multi-site international Price Foundation Genetic Studies with diagnoses of AN, bulimia nervosa (BN), and both AN and BN or eating disorder not otherwise specified (ED-NOS) (N=1,857). Excessive exercise was defined based on responses to the Structured Interview for Anorexic and Bulimic Disorders (SIAB).
  
  
  RESULTS
  Among the eating disorder diagnostic groups, excessive exercise was most common among the purging subtype of AN. Individuals who reported excessive exercise also reported lower minimum BMI, younger age at interview, higher scores on anxiety, perfectionism, and eating disorder symptom measures, more obsessions and compulsions, and greater persistence.
  
  
  CONCLUSIONS
  Excessive exercise may be associated particularly with the purging subtype of AN as well as with a constellation of anxious/obsessional temperament and personality characteristics among women with eating disorders.
authors.affiliation: Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, and Center for Eating Disorders at Sheppard and Enoch Pratt Hospital, Towson, MD, USA.
authors.forename: Hemal
authors.initials: H
authors.lastname: Shroff
authors.forename: Lauren
authors.initials: L
authors.lastname: Reba
authors.forename: Laura M
authors.initials: LM
authors.lastname: Thornton
authors.forename: Federica
authors.initials: F
authors.lastname: Tozzi
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Klump
authors.forename: Wade H
authors.initials: WH
authors.lastname: Berrettini
authors.forename: Harry
authors.initials: H
authors.lastname: Brandt
authors.forename: Steven
authors.initials: S
authors.lastname: Crawford
authors.forename: Scott
authors.initials: S
authors.lastname: Crow
authors.forename: Manfred M
authors.initials: MM
authors.lastname: Fichter
authors.forename: David
authors.initials: D
authors.lastname: Goldman
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Halmi
authors.forename: Craig
authors.initials: C
authors.lastname: Johnson
authors.forename: Allan S
authors.initials: AS
authors.lastname: Kaplan
authors.forename: Pamela
authors.initials: P
authors.lastname: Keel
authors.forename: Maria
authors.initials: M
authors.lastname: LaVia
authors.forename: James
authors.initials: J
authors.lastname: Mitchell
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rotondo
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: D Blake
authors.initials: DB
authors.lastname: Woodside
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000453:epidemiology* / Q000523:psychology; D001007:Anxiety; D052018:Bulimia Nervosa / Q000453:epidemiology* / Q000523:psychology*; D015444:Exercise / Q000523:psychology*; D005260:Female; D006801:Humans; D013694:Temperament