title: Biomechanical characterization of vaginal versus abdominal surgical wound healing in the rabbit.
abstract: OBJECTIVE
  The objective of the study was to compare biomechanical properties of vaginal versus abdominal surgical wound healing in the rabbit.
  
  
  METHODS
  Bilateral 6-mm full-thickness circular segments were excised from the vagina and abdominal skin in 38 New Zealand White female rabbits. Animals were killed 0, 4, 7, 10, 14, 21, 28, and 35 days after wounding, and the wounds were assessed for surface area and tensile properties.
  
  
  RESULTS
  Wound closure and scar contraction were significantly faster in the vagina than the abdomen (P = .001). Baseline tensile strength (P = .05), modulus (P = .001), and tensile energy to break (P = .18) were higher in the abdomen, whereas maximal tissue elongation was higher in the vagina (P = .13). After wounding, a drop in tensile strength, modulus, and tensile energy to break was observed in both tissues through postwounding day 4, followed by a progressive recovery of these properties. A progressive loss of elasticity was noted in both tissues after wounding.
  
  
  CONCLUSIONS
  The surgical wound closes and contracts faster in the rabbit vagina than in its abdomen. Although these tissues have different biomechanical properties at baseline, they regenerate their tensile strength and lose their elasticity at a similar rate.
authors.affiliation: Division of Urogynecology, Evanston Continence Center, Evanston, IL 60201, USA. y-abramov@northwestern.edu
authors.forename: Yoram
authors.initials: Y
authors.lastname: Abramov
authors.forename: Antonio R
authors.initials: AR
authors.lastname: Webb
authors.forename: Jay-James R
authors.initials: JJ
authors.lastname: Miller
authors.forename: Adeeb
authors.initials: A
authors.lastname: Alshahrour
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Botros
authors.forename: Roger P
authors.initials: RP
authors.lastname: Goldberg
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Ameer
authors.forename: Peter K
authors.initials: PK
authors.lastname: Sand
mesh_terms: D000005:Abdomen / Q000503:physiopathology* / Q000601:surgery*; D000818:Animals; D004548:Elasticity; D005260:Female; D011817:Rabbits; D012867:Skin / Q000503:physiopathology*; D013718:Tensile Strength; D013997:Time Factors; D014621:Vagina / Q000503:physiopathology* / Q000601:surgery*; D014945:Wound Healing