The PedsQL as a patient-reported outcome in children and adolescents with Attention-Deficit/Hyperactivity Disorder: a population-based study.
BACKGROUND
Attention-Deficit/Hyperactivity Disorder (ADHD) is the most common chronic mental health condition in children and adolescents. The application of health-related quality of life (HRQOL) as a pediatric population health measure may facilitate risk assessment and resource allocation, the identification of health disparities, and the determination of health outcomes from interventions and policy decisions for children and adolescents with ADHD at the local community, state, and national health level.


METHODS
An analysis from an existing statewide database to determine the feasibility, reliability, and validity of the 23-item PedsQL 4.0 (Pediatric Quality of Life Inventory) Generic Core Scales as a patient-reported outcome (PRO) measure of pediatric population health for children and adolescents with ADHD. The PedsQL 4.0 Generic Core Scales (Physical, Emotional, Social, School Functioning) were completed by families through a statewide mail survey to evaluate the HRQOL of new enrollees in the State of California State's Children's Health Insurance Program (SCHIP). Seventy-two children ages 5-16 self-reported their HRQOL.


RESULTS
The PedsQL 4.0 evidenced minimal missing responses, achieved excellent reliability for the Total Scale Score (alpha = 0.92 child self-report, 0.92 parent proxy-report), and distinguished between healthy children and children with ADHD. Children with ADHD self-reported severely impaired psychosocial functioning, comparable to children with newly-diagnosed cancer and children with cerebral palsy.


CONCLUSIONS
The results suggest that population health monitoring may identify children with ADHD at risk for adverse HRQOL. The implications of measuring pediatric HRQOL for evaluating the population health outcomes of children with ADHD internationally are discussed.
Varni
James W
JW
Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX 77843-3137, USA. jvarni@archmail.tamu.edu
Burwinkle
Tasha M
TM
D000203:Activities of Daily Living; D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology / Q000523:psychology*; D002140:California; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents / Q000523:psychology; D019727:Proxy; D011594:Psychometrics / Q000295:instrumentation*; D011788:Quality of Life; D040841:Resource Allocation; D018570:Risk Assessment; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires