title: Rapid sterilisation of cerebrospinal fluid in meningococcal meningitis: Implications for treatment duration.
abstract: OBJECTIVE
  The aim of this study was to determine the time and total cumulative dose of parenteral antibiotic, required to sterilize the cerebrospinal fluid (CSF) of children presenting with meningococcal meningitis (MM).
  
  
  METHODS
  The study was a retrospective audit of children aged 0-14 years who presented between January 1995 and December 1999 with MM. All cases had a delayed lumbar puncture (LP) at least 1 h after commencing antibiotic therapy and demonstrated at least one of the following: (i) a positive CSF culture of Neisseria meningitidis (n = 6); (ii) Gram negative diplococci on Gram stain (n = 16) or (iii) a positive CSF plasma clearance rate test for N. meningitidis (n = 26).
  
  
  RESULTS
  Forty-eight children were identified with a mean age of 4.4 years. The cumulative dose of antibiotic prior to LP, ranged from 22 to 440 mg/kg body weight. All cases (n = 24) who received a cumulative dose of at least 150 mg/kg of antibiotic, prior to LP, had a sterile CSF. No CSF taken more than 5 h after commencing antibiotics grew N. meningitidis.
  
  
  CONCLUSIONS
  Children in this study with MM had rapid sterilisation of the CSF in less than 6 h. This would support recent recommendations to reduce the duration of antibiotic therapy to 4 days. There is however, lack of long-term data on sequelae with 4 days of treatment.
authors.affiliation: South Auckland Clinical School, University of Auckland, New Zealand.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Crosswell
authors.forename: W Ross
authors.initials: WR
authors.lastname: Nicholson
authors.forename: Diana R
authors.initials: DR
authors.lastname: Lennon
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000187:drug effects* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D008297:Male; D008499:Medical Records; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D009345:Neisseria meningitidis / Q000187:drug effects*; D013129:Spinal Puncture; D013242:Sterilization; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents