title: ARLTS1 variants and melanoma risk.
abstract: Variants in the tumor suppressor gene ARLTS1 (ADP-ribosylation factor-like tumor-suppressor gene 1) have been shown to influence familial cancer risk. Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. We studied the impact of these gene variants on melanoma risk, investigating 351 melanoma patients and 804 control subjects. While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02). An additional risk enhancement, though statistically non-significant, was observed in individuals with multiple melanomas (OR = 2.33, 95% CI = 0.87-6.26, p = 0.08).
authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany. b.frank@dkfz.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Frank
authors.forename: Peter
authors.initials: P
authors.lastname: Meyer
authors.forename: Melanie Barbara
authors.initials: MB
authors.lastname: Boettger
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Henrike
authors.initials: H
authors.lastname: Stapelmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Gast
authors.forename: Christina
authors.initials: C
authors.lastname: Schmitt
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.forename: Consolato
authors.initials: C
authors.lastname: Sergi
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
mesh_terms: D020727:ADP-Ribosylation Factors / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D020727:ADP-Ribosylation Factors; C500039:ARL11 protein, human