title: Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort.
abstract: Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self-reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. abnetc@mail.nih.gov
authors.forename: Christian C
authors.initials: CC
authors.lastname: Abnet
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Fan
authors.forename: Farin
authors.initials: F
authors.lastname: Kamangar
authors.forename: Xiu-Di
authors.initials: XD
authors.lastname: Sun
authors.forename: Philip R
authors.initials: PR
authors.lastname: Taylor
authors.forename: Jian-Song
authors.initials: JS
authors.lastname: Ren
authors.forename: Steven D
authors.initials: SD
authors.lastname: Mark
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Fraumeni
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Sanford M
authors.initials: SM
authors.lastname: Dawsey
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology; D002299:Cardia; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006042:Goiter / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology