title: Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas.
abstract: Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin-10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.
authors.affiliation: Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Portugal.
authors.forename: Manuela
authors.initials: M
authors.lastname: Flórido
authors.forename: Rui
authors.initials: R
authors.lastname: Appelberg
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006099:Granuloma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009162:Mycobacterium avium / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity; D009336:Necrosis; D016133:Polymerase Chain Reaction / Q000379:methods; D013045:Species Specificity; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology
chemical_list: D016753:Interleukin-10