Determination of the synthetic origin of methamphetamine samples by 2H NMR spectroscopy.
Samples of methamphetamine, prepared according to the most common synthetic pathways, were submitted to natural-abundance 2H NMR spectroscopy. The deuterium content at the various sites of the molecule was found to depend on its synthetic history. The technique provides a chemical fingerprint of methamphetamine samples and can give hints to trace back the starting materials and the synthetic procedures.
Armellin
Silvia
S
Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, and Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy.
Brenna
Elisabetta
E
Frigoli
Samuele
S
Fronza
Giovanni
G
Fuganti
Claudio
C
Mussida
Daniele
D
D003903:Deuterium; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000138:chemical synthesis; D015394:Molecular Structure; D012680:Sensitivity and Specificity
D008694:Methamphetamine; D003903:Deuterium