title: Stereoselective synthesis of (+)-goniothalesdiol.
abstract: Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid. Key features include an FeCl3 mediated THF formation with very high selectivity. Synthesis of natural gonithalesdiol and its analogue 2,5-bis-epi-goniothalesdiol was achieved from a common intermediate.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. prasad@orgchem.iisc.ernet.in
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
authors.forename: Shivajirao L
authors.initials: SL
authors.lastname: Gholap
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C512388:goniothalesdiol