title: [Hypersensitivity reaction to systemic corticosteroids in a hemodialysis patients].
abstract: Hypersensitivity reactions are a feared complication of hemodialysis considering their potential for a serious and eventually fatal course. This association could reflect a number of different exposures, including concomitant medications. Like this, systemic steroid-induced hypersensitivity reactions do occur, althought their incidence is extremely rare. A few reactions related to metylprednisolone have been reported in renal transplantation. The diagnosis could be confirmed by the patient history and performing skin testing, oral or parenteral challenge or by the evidence of specific IgE. We report on a 39-year-old woman undergoing dialysis therapy in whom severe bronchospasm was induced by corticosteroids. She has a positive systemic reaction on the oral steroid challenge test. A successful desensitization regimen for safe administration was achieved. The recognition of high-risk subjects and alternative therapeutic approach are critical, mainly in the management of patients while receiving corticosteroids or a renal allograft.
authors.affiliation: Sección de Nefrología, Hospital General Universitario de Elche, Hospital General Universitario de Elche. nefro_elx@gva.es
authors.forename: A E
authors.initials: AE
authors.lastname: Sirvent
authors.forename: I
authors.initials: I
authors.lastname: Fernández
authors.forename: R
authors.initials: R
authors.lastname: Enríquez
authors.forename: J G
authors.initials: JG
authors.lastname: Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Santos Calle
authors.forename: J
authors.initials: J
authors.lastname: Samper
authors.forename: M D
authors.initials: MD
authors.lastname: Arenas
authors.forename: A
authors.initials: A
authors.lastname: Reyes
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000150:complications; D001986:Bronchial Spasm / Q000139:chemically induced*; D003888:Desensitization, Immunologic; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications; D006435:Renal Dialysis; D012882:Skin Tests
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D001241:Aspirin; D008775:Methylprednisolone