title: Direct patterning of centrosome arrays as templates for the assembly of microtubules.
abstract: We have achieved, for the first time, the selective patterning of centrosomes onto solid substrates. The use of such patterned centrosome arrays as templates for the directed polymerization of microtubules was also demonstrated. Centrosomes are small organelles in animal cells that serve as nucleation and organization centers of microtubules. Directed assembly of microtubules on the patterned centrosome arrays provides a new route to control the positions and directions of microtubules on surfaces. Combining the patterning of the isolated centrosomes and the directed growth of microtubules may lead to the generation of desired microtubule networks for bio-based nanodevices.
authors.affiliation: Rensselaer Nanotechnology Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3950, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Shang
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Dordick
authors.forename: Robert E
authors.initials: RE
authors.lastname: Palazzo
authors.forename: Richard W
authors.initials: RW
authors.lastname: Siegel
mesh_terms: D000327:Adsorption; D018385:Centrosome / Q000737:chemistry* / Q000648:ultrastructure*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization / Q000379:methods*; D008870:Microtubules / Q000737:chemistry* / Q000648:ultrastructure*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods
chemical_list: D020099:Coated Materials, Biocompatible