title: [Correlation between expression of the MTA1 gene and carcinomas of larynx].
abstract: OBJECTIVE
  To study the relation between Mta1 gene (metastasis associated gene, meta gene) and lymph node metastasis of laryngeal carcinomas.
  
  
  METHODS
  Reverse transcription polymerase chain reaction(RT-PCR) technique was used to detect the expression of Mta1 mRNA in 30 carcinoma of larynx tissue cases, 12 lymph nodes and 10 normal larynx tissue cases.
  
  
  RESULTS
  The frequency of MTA1 overexpression was 100% (8/8) in primary carcinomas of larynx with metastasis but only 22.7% (5/22) in toes without metastasis (P<0.01). Expression of MTA1 was 87.5%(7/8) in lymph nodes with metastasis but only 0(0/4) in toes without metastasis(P<0.05). The frequency of Mta1 overexpression was 43.3% (13/30) in primary carcinomas of larynx.
  
  
  CONCLUSIONS
  Our data suggest that the overexpression of the MTA1 gene correlates with lymph node metastasis of carcinomas of larynx. Mta1 gene will probably become a valuable gene for judging metastasis of laryngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors.forename: Huihe
authors.initials: H
authors.lastname: Wang
authors.forename: Guangwu
authors.initials: G
authors.lastname: Huang
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wei
authors.forename: Ligen
authors.initials: L
authors.lastname: Mo
authors.forename: Guoqian
authors.initials: G
authors.lastname: Kuang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D015534:Trans-Activators
chemical_list: C089320:MTA1 protein, human; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; D006655:Histone Deacetylases