Cortical modulation of dorsal column nuclei: a computational study.
We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.
Sánchez
Eduardo
E
Grupo de Sistemas Intelixentes (GSI), Departamento de Electrónica e computación, Facultade de Físicas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. eduardos@usc.es
Barro
Senén
S
Mariño
Jorge
J
Canedo
Antonio
A
D000818:Animals; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D008564:Membrane Potentials / Q000502:physiology / Q000528:radiation effects; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology*; D013116:Spinal Cord / Q000166:cytology*; D013569:Synapses / Q000502:physiology