title: Chronic pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: effect on quality of life.
abstract: Chronic pouchitis can be observed in up to 30% of patients after proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). It remains a poorly understood complication and often requires chronic antibiotic and antidiarrheal treatment. We hypothesized that its occurrence can be predicted by distinct clinical parameters and that it adversely affects quality of life. Sixty-eight of 129 consecutive UC patients who underwent IPAA over a 10-year period were evaluated by Cleveland Clinic Global Quality of Life questionnaires, telephone interviews, and by chart review. Using bivariate comparison, clinical predictors for the occurrence of chronic pouchitis were sought, and postoperative data analyzed with regard to functional results and quality of life. Nineteen of 68 patients (28%) experienced chronic pouchitis, but its occurrence could not be predicted by any variable assessed. Patients with chronic pouchitis complained of more frequent fecal incontinence (32% vs. 4% in controls; P < 0.01), of more frequent bowel movements (7.7/day vs. 6.2/day; P < 0.05), and experienced severe abdominal pain more often (P < 0.05). Overall quality of life and satisfaction with surgery, as well as subjective health and energy levels were lower in patients with chronic pouchitis (P < 0.01); however, greater than 80% of these patients would consider undergoing the same procedure again.
authors.affiliation: Price Institute of Surgical Research, Department of Surgery, University of Louisville, KY 40292, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Turina
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Pennington
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kimberling
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Stromberg
authors.forename: Robert E
authors.initials: RE
authors.lastname: Petras
authors.forename: Susan
authors.initials: S
authors.lastname: Galandiuk
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000930:Antidiarrheals / Q000627:therapeutic use; D001294:Attitude to Health; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches; D003672:Defecation / Q000502:physiology; D005242:Fecal Incontinence / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011183:Postoperative Complications; D019449:Pouchitis / Q000150:complications / Q000523:psychology*; D011788:Quality of Life; D012189:Retrospective Studies
chemical_list: D000930:Antidiarrheals