title: Mathematical modeling of gravitational effects on the circulation: importance of the time course of venous pooling and blood volume changes in the lungs.
abstract: A dip in blood pressure (BP) in response to head-up tilt (HUT) or active standing might be due to rapid pooling in the veins below the heart (preload) or muscle activation-induced drop in systemic vascular resistance (afterload). We hypothesized that, in the cardiovascular response to passive HUT, where, in contrast to active standing, little BP dip is observed, features affecting the preload play a key role. We developed a baroreflex model combined with a lumped-parameter model of the circulation, including viscoelastic stress-relaxation of the systemic veins. Cardiac contraction is modeled using the varying-elastance concept. Gravity affects not only the systemic, but also the pulmonary, circulation. In accordance with the experimental results, model simulations do not show a BP dip on HUT; the tilt-back response is also realistic. If it is assumed that venous capacities are steady-state values, the introduction of stress-relaxation initially reduces venous pooling. The resulting time course of venous pooling is comparable to measured impedance changes. When venous pressure-volume dynamics are neglected, rapid (completed within 30 s) venous pooling leads to a drop in BP. The direct effect of gravity on the pulmonary circulation influences the BP response in the first approximately 5 s after HUT and tilt back. In conclusion, the initial BP response to HUT is mainly determined by the response of the venous system. The time course of lower body pooling is essential in understanding the response to passive HUT.
authors.affiliation: Dept. of Physiology, Rm. M01-216, Academic Medical Center, Univ. of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: van Heusden
authors.forename: J
authors.initials: J
authors.lastname: Gisolf
authors.forename: W J
authors.initials: WJ
authors.lastname: Stok
authors.forename: S
authors.initials: S
authors.lastname: Dijkstra
authors.forename: J M
authors.initials: JM
authors.lastname: Karemaker
mesh_terms: D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D001809:Blood Viscosity; D001810:Blood Volume / Q000502:physiology*; D002319:Cardiovascular System / Q000503:physiopathology; D005260:Female; D006112:Gravitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011652:Pulmonary Circulation / Q000502:physiology*; D018667:Tilt-Table Test; D014680:Veins / Q000502:physiology*