Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.
Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.
Tachibana
Masayoshi
M
Saitama Cancer Center, Ina, Saitama, Japan.
Lu
Lingmin
L
Hiai
Hiroshi
H
Tamura
Atsushi
A
Matsushima
Yoshibumi
Y
Shisa
Hayase
H
D000818:Animals; D002874:Chromosome Mapping; D004054:Diethylstilbestrol / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic; D013737:Testis / Q000187:drug effects*
D052244:Endocrine Disruptors; D004054:Diethylstilbestrol; D011388:Prolactin