title: Mycobacterium tuberculosis-induced carpal tunnel syndrome: management and follow-up evaluation.
abstract: OBJECTIVE
  To determine the clinical characteristics of 12 patients with Mycobacterium tuberculosis-induced carpal tunnel syndrome. This article also presents our intraoperative findings and surgical treatment results.
  
  
  METHODS
  Twelve patients with tuberculosis-induced carpal tunnel syndrome who had surgery during a 10-year period that began in March 1991 were reviewed. The entrance criterion was a positive histologic report of tuberculosis for surgical specimens. The preoperative evaluation leading to diagnosis was reviewed for all patients. Transection of the transverse carpal ligament and complete synovectomy were performed for all patients. After surgery the patients were given an antituberculosis regimen for 1 year and were followed up for an average of 6 years.
  
  
  RESULTS
  Twelve cases from a total of 1,180 patients with carpal tunnel syndrome were traced to M tuberculosis involvement of synovial tissue of the flexor tendons. Ten patients had large rice bodies in thick synovial membranes, and in the other 2 patients thick synovial tissue with yellow exudates were observed during surgery. In contrast to tendon involvement with rupture, no direct median nerve involvement was noted. Histopathologic study results of surgical specimens were positive for tuberculosis in all patients. Eight of 10 initial smears showed acid-fast bacillus and all 10 cultures of the specimens were positive for tubercle bacilli. Surgery and antituberculosis therapy were associated with a desirable outcome and sensory disturbance in the median nerve distribution resolved in all patients. Anterior wrist swelling disappeared and there has been no clinical or laboratory evidence of recurrence in all treated patients.
  
  
  CONCLUSIONS
  Early diagnosis and surgical treatment combined with antituberculosis medical treatment are important in treating this condition. All patients treated were relieved of symptoms of synovial proliferation at the wrist, with no recurrence of the condition during the follow-up period.
  
  
  METHODS
  Therapeutic, Level IV.
authors.affiliation: Department of Plastic and Reconstructive Surgery, 15th Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. esmail_hassanpour@yahoo.com
authors.forename: Seyed-Esmail
authors.initials: SE
authors.lastname: Hassanpour
authors.forename: Jamal
authors.initials: J
authors.lastname: Gousheh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D002349:Carpal Tunnel Syndrome / Q000382:microbiology* / Q000628:therapy*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D013585:Synovitis / Q000382:microbiology / Q000628:therapy; D013710:Tendons / Q000382:microbiology / Q000601:surgery; D014394:Tuberculosis, Osteoarticular / Q000175:diagnosis* / Q000628:therapy*; D014955:Wrist Joint / Q000382:microbiology* / Q000601:surgery
chemical_list: D000904:Antibiotics, Antitubercular