title: Significant exercise-induced hypoxaemia with equivocal desaturation in patients with chronic obstructive pulmonary disease.
abstract: BACKGROUND
  The wide 95% confidence interval for S(a)O2 measured by pulse oximetry (S(P)O2) and the inherent characteristics of the oxyhaemoglobin dissociation curve can lead to modest but significant decreases in P(a)O2 (deltaP(a)O2 > or = 5 mmHg) that may be under-appreciated.
  
  
  OBJECTIVE
  To avoid missing potentially significant deltaP(a)O2 by using S(P)O2, this study establishes a threshold of deltaS(P)O2 to detect deltaP(a)O2 by examining the correlation between deltaS(P)O2 and deltaP(a)O2.
  
  
  METHODS
  We enrolled 29 elderly patients with moderate to severe chronic obstructive pulmonary disease as assessed by lung function testing. Arterial blood gases and S(P)O2 measurements were carried out during maximal exercise testing. The patients were assigned to groups based on P(a)O2 measurements: group 1 had P(a)O2 at peak exercise (P(a)O2peak) > or = 60 mmHg without a deltaP(a)O2; group 2 had P(a)O2peak > or = 60 mmHg with a deltaP(a)O2; group 3 had P(a)O2peak < 60 mmHg without a deltaP(a)O2; and group 4 had P(a)O2peak < 60 mmHg with a deltaP(a)O2.
  
  
  RESULTS
  The study population was evenly distributed between groups 1, 2 and 4. However, group 3 did not have any patients enrolled in this study that met group 3 criteria. The sensitivity of pulse oximetry required to detect S(a)O2 below 90% was 19%. DeltaS(P)O2 of 3% may increase the low sensitivity of S(P)O2 and was shown by a 92% positive predictive value for deltaP(a)O2 > or = 5 mmHg.
  
  
  CONCLUSIONS
  This study suggests that important changes in oxygenation may be avoided if using deltaS(P)O2 rather than absolute values of S(P)O2 in patients with chronic obstructive pulmonary disease undergoing exercise testing to detect exercise-induced hypoxaemia.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Buddhist Taipei Tzu Chi General Hospital, Xindian City, Taiwan, ROC. yuan1007@ms36.hinet.net
authors.forename: M-L
authors.initials: ML
authors.lastname: Chuang
authors.forename: I-F
authors.initials: IF
authors.lastname: Lin
authors.forename: J R E
authors.initials: JR
authors.lastname: Vintch
authors.forename: B S-J
authors.initials: BS
authors.lastname: Ho
authors.forename: S-W
authors.initials: SW
authors.lastname: Chao
authors.forename: J J W
authors.initials: JJ
authors.lastname: Ker
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D015444:Exercise / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000150:complications / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications
chemical_list: D010100:Oxygen