title: Assessment of the corneal endothelium in acute ultraviolet keratitis.
abstract: BACKGROUND
  The purpose of this prospective case-control study was to investigate whether exposure to ultraviolet (UV) light produces detectable damage to the corneal endothelium in patients presenting with acute UV keratitis.
  
  
  METHODS
  Non-contact specular microscopy was performed on 20 consecutive patients who presented to our clinic from July 2000 to July 2002 with acute UV keratitis and similarly on 20 age-matched healthy controls. Both the coefficient of variation in mean cell size (CV) and the mean cell density (CD) were compared in these two groups using the Student t-test.
  
  
  RESULTS
  Mean age was 28.6 years in the study group and 28.4 years in the control group. The mean CD in the patient group was 2609.6 (SD = 103.47) and in the control group 2632.87 (SD = 117.05). No statistically significant difference was found between the mean CDs in these two groups (p = 0.93). The mean CV in the patient group was 46.7 (SD = 4.40) and in the control group 45.4 (SD = 5.60). Similarly, there was no statistically significant difference between the mean CVs in these two groups (p = 0.85).
  
  
  CONCLUSIONS
  UV light exposure does not seem to have a direct immediate effect on the corneal endothelium in humans with acute UV keratitis. Whether UV light produces cumulative and/or longer-term damage requires further studies with a larger number of patients and a longer follow-up time.
authors.affiliation: Department of Ophthalmology, Temple University Hospital, Philadelphia, PA 19140, USA. danynajjar@hotmail.com
authors.forename: Dany M
authors.initials: DM
authors.lastname: Najjar
authors.forename: Shady T
authors.initials: ST
authors.lastname: Awwad
authors.forename: Wadih M
authors.initials: WM
authors.lastname: Zein
authors.forename: Walid F
authors.initials: WF
authors.lastname: Haddad
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D004728:Endothelium, Corneal / Q000293:injuries / Q000473:pathology* / Q000528:radiation effects*; D006801:Humans; D007634:Keratitis / Q000209:etiology* / Q000473:pathology*; D008297:Male; D009784:Occupational Diseases / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014896:Welding