Abnormal bone remodelling and increased levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) in Waldenström macroglobulinaemia.
Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP-1alpha was elevated in WM; untreated patients had higher MIP-1alpha levels than patients in remission or with active disease after treatment. MIP-1alpha correlated with increased bone resorption, beta2-microglobulin and splenomegaly. Receptor activator of nuclear factor-kappaB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP-1alpha in WM.
Terpos
Evangelos
E
Department of Haematology, General Airforce Hospital, Athens, Greece. e.terpos@imperial.ac.uk
Anagnostopoulos
Athanasios
A
Kastritis
Efstathios
E
Bamias
Aristotelis
A
Tsionos
Konstantinos
K
Dimopoulos
Meletios-Athanassios
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D001862:Bone Resorption / Q000097:blood / Q000209:etiology*; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D005260:Female; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000097:blood / Q000209:etiology; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000150:complications*; D001613:beta 2-Microglobulin / Q000097:blood
D015415:Biomarkers; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins; D001613:beta 2-Microglobulin