title: Acute myocardial infarction induced by cisplatin-based combination chemotherapy for malignant melanoma: a case report.
abstract: A 61-year-old woman with stage IV malignant melanoma suffered acute myocardial infarction during the third course of chemotherapy with cisplatin, dacarbazine, nimustine hydrochloride and tamoxifen citrate, despite no serious problem occurring during the first and second courses of chemotherapy. Since this patient, excluding menopause, had no significant risk factor for coronary heart disease before the start of chemotherapy, the infarction was likely to be attributable to the chemotherapy regimen. Chemotherapy should be used cautiously in patients with coronary risk factors before treatment is begun.
authors.affiliation: Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugamura
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Tanoue
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kageshita
authors.forename: Tomomichi
authors.initials: T
authors.lastname: Ono
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002114:Calcinosis / Q000150:complications; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications; D003606:Dacarbazine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis; D015376:Nimustine / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy*; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D013629:Tamoxifen; D015376:Nimustine; D003606:Dacarbazine; D002945:Cisplatin