The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate.
This case report presents a patient with advanced diffuse panbronchiolitis accompanied by chronic respiratory failure, marked cachexia, and refractory spontaneous pneumothorax. Because instillation of a pleurodesis agent and thoracoscopy were considered highly risky and invasive, we instead treated the patient with intravenous administration of a coagulation factor XIII concentrate, and the pneumothorax resolved. This case suggests refractory pneumothorax in a restrictive ventilatory disorder can be effectively treated with noninvasive intravenous administration of coagulation factor XIII concentrate.
Murata
Akira
A
Department of Pulmonary Medicine, Infection and Oncology, Nippon Medical School, Sendagi, Tokyo, Japan. a-murata@nms.ac.jp
Kouno
Ayumi
A
Yamamoto
Kazuo
K
Yoshioka
Hiroko
H
Kida
Kozui
K
Kudoh
Shoji
S
D001988:Bronchiolitis / Q000150:complications*; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D011030:Pneumothorax / Q000188:drug therapy*
D005176:Factor XIII