title: Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease.
abstract: Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and in an animal model of Parkinson's disease based on increased polysialic acid-like immunoreactivity. Changes in neurogenesis often appear parallel to changes in angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-1). Using immunohistochemistry, we identified in this study upregulation of VEGF in the substantia nigra but not in the striatum of patients with Parkinson's disease by enzyme-linked immunosorbent assay. Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
authors.forename: Keiichirou
authors.initials: K
authors.lastname: Wada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Masashi
authors.initials: M
authors.lastname: Takanashi
authors.forename: Jiro
authors.initials: J
authors.lastname: Fukae
authors.forename: Hideki
authors.initials: H
authors.lastname: Oizumi
authors.forename: Toru
authors.initials: T
authors.lastname: Yasuda
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Hideki
authors.initials: H
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D003952:Diagnostic Imaging / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000145:classification / Q000378:metabolism*; D018709:Statistics, Nonparametric; D042461:Vascular Endothelial Growth Factor A / Q000145:classification / Q000378:metabolism*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor