title: Effect of multisite radiofrequency ablation on porcine renal function.
abstract: OBJECTIVE
  The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results.
  
  
  METHODS
  Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10%, 15%, and 20% ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks.
  
  
  RESULTS
  In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10%, 15%, and 20% ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlation with ablation volume.
  
  
  CONCLUSIONS
  The volume of RFA correlates with an acute change in renal function in the porcine model for both nonischemic and cold-ischemia groups. This study may help predict the extent of acute renal dysfunction in patients undergoing RFA for large or multiple renal masses. These results also suggest renal function may recover after nonischemic RFA.
authors.affiliation: Department of Urology, The University of Texas Southwestern Medical Center, Dallas 75390-9110, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Duchene
authors.forename: D Brooke
authors.initials: DB
authors.lastname: Johnson
authors.forename: Lucas
authors.initials: L
authors.lastname: Jacomides
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ogan
authors.forename: Arthur I
authors.initials: AI
authors.lastname: Sagalowsky
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Cadeddu
mesh_terms: D000208:Acute Disease; D000818:Animals; D017115:Catheter Ablation / Q000009:adverse effects*; D003080:Cold Temperature; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D007511:Ischemia / Q000209:etiology* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D034421:Sus scrofa
chemical_list: D003404:Creatinine