Controlled-release microchips.
Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.
Sharma
Sadhana
S
Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA.
Nijdam
A Jasper
AJ
Sinha
Piyush M
PM
Walczak
Robbie J
RJ
Liu
Xuewu
X
Cheng
Mark M-C
MM
Ferrari
Mauro
M
D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry; D012825:Silicon / Q000737:chemistry
D003692:Delayed-Action Preparations; D011108:Polymers; D012825:Silicon