title: [Acyclovir combined with plasma exchange for disseminated varicella-zoster virus infection after bone marrow transplantation].
abstract: In 2001, a 45-year-old man with severe aplastic anemia received a bone marrow transplantation from his HLA-identical sister, 2.5 years after which he developed severe liver dysfunction together with abdominal pain, disturbance of consciousness and generalized vesicles. Disseminated varicella-zoster virus infection was diagnosed by the detection of VZV DNA. Acyclovir and plasma exchange rapidly controlled his VZV-related symptoms and signs. Disseminated VZV infection is often fatal, but acyclovir and plasma exchange may be useful for such infection by reducing the circulating viral load.
authors.affiliation: Department of Hematology, Juntendo University, Shizuoka Hospital.
authors.forename: Chunyong
authors.initials: C
authors.lastname: Lee
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koike
authors.forename: Kazuo
authors.initials: K
authors.lastname: Oshimi
authors.forename: Seitarou
authors.initials: S
authors.lastname: Terakura
authors.forename: Yositaka
authors.initials: Y
authors.lastname: Kodera
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000628:therapy; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003131:Combined Modality Therapy; D006562:Herpes Zoster / Q000209:etiology / Q000628:therapy*; D014645:Herpesvirus 3, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir