title: Bisabolane sesquiterpenes from the roots of Ligularia cymbulifera.
abstract: Eight new highly oxygenated bisabolane sesquiterpenes (1-8), of which one contains a chlorine atom, were obtained in a phytochemical investigation of the roots of Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of (1)H NMR coupling constants and by NOE experiments. Compounds 1-8 were evaluated for antimicrobial activity against three bacterial cultures and a yeast culture.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Fei
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wu
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D012717:Sesquiterpenes