title: Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A.
abstract: Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia-II were evaluated for their antiviral activity against various viruses such as HIV HSV-1, HSV-2, and ECMV.
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: Joon Hee
authors.initials: JH
authors.lastname: Hong
authors.forename: So-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
authors.forename: Jung-Hyuck
authors.initials: JH
authors.lastname: Cho
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans
chemical_list: D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine