Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25.
Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 microM, respectively.
Uchida
Ryuji
R
School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Kim
Yong-Pil
YP
Namatame
Ichiji
I
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D002478:Cells, Cultured; D002788:Cholesterol Esters / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D002788:Cholesterol Esters; D004224:Diterpenes; D000960:Hypolipidemic Agents; D007211:Indoles; D012717:Sesquiterpenes; D014280:Triglycerides; C510263:sespendole