title: Peripapillary retinal nerve fiber layer thickness variations with myopia.
abstract: OBJECTIVE
  To determine the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness and myopia using optical coherence tomography (OCT).
  
  
  METHODS
  Prospective observational case series.
  
  
  METHODS
  One hundred thirty-two young males with myopia (spherical equivalent [SE], -0.50 to -14.25 diopters) underwent ophthalmic examination of one randomly selected eye. Optical coherence tomography (OCT-1, version 4.1) was performed by a single operator using circular scans concentric with the optic disc with scan diameters of 3.40 mm, 4.50 mm, and 1.75 x vertical disc diameter (VDD). For each scan diameter, mean peripapillary RNFL thickness was calculated. Statistical analysis comprised repeated-measurements analysis and Pearson correlation.
  
  
  RESULTS
  Mean peripapillary RNFL thickness did not correlate with SE for the 3.40-mm (r = -0.11, P = 0.22), 4.50-mm (r = -0.103, P = 0.24), or 1.75xVDD (r = -0.08, P = 0.36) OCT scan diameters. Neither did mean peripapillary RNFL thickness correlate with axial length for the 3.40-mm (r = -0.04, P = 0.62), 4.50-mm (r = 0.03, P=0.75), or 1.75xVDD (r = -0.02, P = 0.78) scan diameters. Mean peripapillary RNFL thicknesses for the 3.40-mm, 4.50-mm, and 1.75xVDD scans were 101.1+/-8.2 microm (95% confidence interval [CI], 99.4-102.8), 78.9+/-8.2 microm (95% CI, 77.5-80.3), and 97.5+/-10.9 microm (95% CI, 95.6-99.4), respectively.
  
  
  CONCLUSIONS
  Mean peripapillary RNFL thickness did not vary with myopic SE or axial length for any OCT scan diameter investigated. Retinal NFL thickness measurements may be a useful parameter to assess and monitor glaucoma damage in myopic subjects.
authors.affiliation: Singapore National Eye Centre & Singapore Eye Research Institute, Singapore.
authors.forename: Sek-Tien
authors.initials: ST
authors.lastname: Hoh
authors.forename: Marcus C C
authors.initials: MC
authors.lastname: Lim
authors.forename: Steve K L
authors.initials: SK
authors.lastname: Seah
authors.forename: Albert T H
authors.initials: AT
authors.lastname: Lim
authors.forename: Sek-Jin
authors.initials: SJ
authors.lastname: Chew
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Foster
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000328:Adult; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009216:Myopia / Q000150:complications*; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D009900:Optic Nerve / Q000033:anatomy & histology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular