Autopsy findings in the nervous system and ovarian tumour of two patients with paraneoplastic cerebellar degeneration.
OBJECTIVE
To review autopsy findings in paraneoplastic cerebellar degeneration.


METHODS
We report the autopsy results of two individuals with paraneoplastic cerebellar degeneration and ovarian cancer.


RESULTS
Both patients had extensive loss of cerebellar Purkinje cells and general activation of microglia in the central nervous system, as well as signs of immunactivation in the medulla.


CONCLUSIONS
The immunoactivation in PCD is widespread and involving more than the cerebellum.
Storstein
A
A
Department of Clinical Medicine, University of Bergen, Bergen, Norway. anette.storstein@helse-bergen.no
Krossnes
B
B
Vedeler
C A
CA
D000369:Aged, 80 and over; D001344:Autopsy; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000473:pathology*; D011689:Purkinje Cells / Q000502:physiology