title: Peripheral T-cell lymphoma-unspecified (PTCL-U) presenting with hypereosinophilic syndrome and pleural effusions.
abstract: Hypereosinophilic syndrome (HES) is a clinical disorder characterized by persistent eosinophilia and systemic involvement, in which a specific causative factor for the eosinophilia cannot be verified during a certain period of time. There have been only a few reported cases of this syndrome associated with malignant lymphoma. We report a case of peripheral T-cell lymphoma-unspecified with hypereosinophilic syndrome. The patient was a 42-year-old woman with an uncontrolled fever and a sore throat. Eosinophilia was observed on the peripheral blood smear. We confirmed the diagnosis by bone marrow and liver biopsies:. A bone marrow aspiration demonstrated markedly increased eosinophils (24.8%), and a liver biopsy demonstrated infiltration by scattered eosinophils and atypical lymphoid cells, which were confirmed to be T-cell lymphoma cells. This case was a distinctive presentation of peripheral T-cell lymphoma with hypereosinophilic syndrome, probably due to a paraneoplastic condition.
authors.affiliation: Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Choi
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Paik
authors.forename: Yoon Hwan
authors.initials: YH
authors.lastname: Chang
authors.forename: Seung-Sook
authors.initials: SS
authors.lastname: Lee
authors.forename: Baek-Yeol
authors.initials: BY
authors.lastname: Ryoo
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Yang
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000175:diagnosis*; D010996:Pleural Effusion / Q000209:etiology*; D012008:Recurrence