title: Antimicrobial activity of tigecycline against recent isolates of respiratory pathogens from Asian countries.
abstract: In vitro activities of tigecycline were compared with 15 other comparator agents against recent clinical isolates of respiratory pathogens (623 Streptococcus pneumoniae, 105 Staphylococcus aureus, 92 Klebsiella pneumoniae, and 84 Haemophilus influenzae isolates) collected from 11 Asian countries. All isolates of S. pneumoniae from Asian countries were susceptible to tigecycline regardless of penicillin susceptibility with MIC90 of <or=0.06 mg/L. Both methicillin-resistant and methicillin-susceptible S. aureus isolates were susceptible to tigecycline with very low MIC90 values (0.25 and 0.12 mg/L, respectively). Tigecycline was also active against K. pneumoniae (98.9% susceptible; MIC50, 1 mg/L; MIC90, 2 mg/L) including 10 extended-spectrum beta-lactamase-producing isolates and H. influenzae (100% susceptible; MIC50 and MIC90, 0.12 mg/L) from Korea. Data confirmed that tigecycline has an excellent in vitro activity against drug-resistant clinical isolates of respiratory pathogens from Asian countries.
authors.affiliation: Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Sulhee
authors.initials: S
authors.lastname: Park
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Kwon
authors.forename: Sang Taek
authors.initials: ST
authors.lastname: Heo
authors.forename: Seong Yeol
authors.initials: SY
authors.lastname: Ryu
authors.forename: Won Sup
authors.initials: WS
authors.lastname: Oh
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline