title: A new convenient synthesis of propargylic fluorohydrins and 2,5-disubstituted furans from fluoropropargyl chloride.
abstract: Fluoropropargyl chloride reacted with carbonyl compounds to give propargylic fluorohydrins under mild conditions and in good yields; however, at higher temperatures and longer reaction times, 2,5-disubstituted furans are obtained, also in good yields. Fluorohydrins can be readily oxidized to alpha-fluoroketones and alpha-fluorocarboxylic acids with Jones' reagent.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D005663:Furans / Q000138:chemical synthesis*; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005663:Furans; D006844:Hydrocarbons, Cyclic; D006845:Hydrocarbons, Fluorinated