Predictive value of exfoliative cytology in pigmented conjunctival lesions.
OBJECTIVE
Pigmented lesions of the conjunctiva are often difficult to classify clinically. Exfoliative cytology may be helpful, but reliable data regarding the sensitivity and specificity of this test are currently lacking. We determined the value of exfoliative cytology with regard to pigmented conjunctival lesions.


METHODS
A total of 294 smears from 182 patients were screened for malignancy within 6 months of exfoliative cytology. Smears were classified according to the following categories: grade 0 = insufficient material for diagnosis; grade 1 = normal conjunctival cells; grade 2 = melanocytes with mild atypia; grade 3 = melanocytes with moderate atypia, and grade 4 = melanocytes with severe atypia.


RESULTS
The sensitivity, specificity, positive predictive value and negative predictive value of exfoliative cytology were 85%, 78%, 59% and 93%, respectively.


CONCLUSIONS
Exfoliative cytology is a fast, easy and non-invasive technique that may be used in the evaluation of patients with a pigmented conjunctival lesion.
Keijser
Sander
S
Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands. s.keijser@lumc.nl
van Luijk
Chantal M
CM
Missotten
Guy S
GS
Veselic-Charvat
Maud
M
de Wolff-Rouendaal
Didi
D
de Keizer
Rob J W
RJ
D000328:Adult; D003229:Conjunctival Diseases / Q000145:classification / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000145:classification / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000145:classification / Q000473:pathology*; D008548:Melanosis / Q000145:classification / Q000473:pathology*; D009508:Nevus, Pigmented / Q000145:classification / Q000473:pathology*; D011230:Precancerous Conditions / Q000145:classification / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity