Selective disappearance of donor-specific antibodies and absence of acute rejection after liver transplantation in a patient with a strongly positive lymphocyte crossmatch.
We report on a young female, who received a cadaveric liver transplant from a donor who was a zero antigen match, and to whom she has had a strongly positive crossmatch. Immediately after transplantation, her panel reactive antibodies dropped from 55% to 0%, a value which remained for nearly 3 weeks. She subsequently, redeveloped her pretransplant anti-HLA antibodies, though at a lower level, with the exception of those specific to the donor HLA antigens. She also did not develop any acute rejection episodes during the 6 months of follow-up.
Bastani
Bahar
B
Division of Nephrology, Saint Louis University Health Sciences Center, Saint Louis, Missouri, USA. bastanib@slu.edu
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001788:Blood Grouping and Crossmatching; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000906:Antibodies; D006680:HLA Antigens