Immunohistochemical study of caveolin-1 and -2 in the rat retina.
The expression of caveolin-1 and -2 in the retina was examined; Western blot analysis showed that both were present. Immunohistochemistry indicated that caveolin-1 was expressed in the majority of retinal layers, including the ganglion cell layer, inner plexiform layer, outer plexiform layer, and in the vascular endothelial cells of the retina. Caveolin-2 was primarily immunostained in the vessels, but in a few other elements as well. This is the first demonstration of caveolin differential expression in the retina of rats, and suggests that caveolin plays an important role in signal transduction in glial cells and neuronal cells.
Kim
Heechul
H
Department of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea.
Lee
Taeki
T
Lee
Jeeyoung
J
Ahn
Meejung
M
Moon
Changjong
C
Wie
Myung Bok
MB
Shin
Taekyun
T
D000818:Animals; D051242:Caveolin 1 / Q000032:analysis* / Q000276:immunology; D051243:Caveolin 2 / Q000032:analysis* / Q000276:immunology; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000737:chemistry*
C495546:Cav2 protein, rat; D051242:Caveolin 1; D051243:Caveolin 2