title: Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
abstract: Three linear sesquiterpene lactones, anthecotulide (1), hydroxyanthecotulide (2), and acetoxyanthecotulide (3), were isolated from the aerial parts of Anthemis auriculata. Five known flavonoids, taraxa-20(30)en-3beta-ol (4), and methyl vanillate (5) were also isolated. The structures and the relative configuration of the new compounds 2 and 3 were deduced by spectroscopic methods. The in vitro activity of compounds 1-5 against 10 bacterial species and one fungus was tested using the microdilution method.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-157 71 Athens, Greece.
authors.forename: Revecca
authors.initials: R
authors.lastname: Theodori
authors.forename: Anastasia
authors.initials: A
authors.lastname: Karioti
authors.forename: Ana
authors.initials: A
authors.lastname: Rancić
authors.forename: Helen
authors.initials: H
authors.lastname: Skaltsa
mesh_terms: D031166:Anthemis / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C510712:4-O-acetoxyanthecotulide; C510711:4-hydroxyanthecotulide; D000890:Anti-Infective Agents; D005419:Flavonoids; D007783:Lactones; D012717:Sesquiterpenes; C499300:anthecotulide