title: Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry.
abstract: The genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.
authors.affiliation: Department of Child and Adolescent Psychiatry, University of Ulm, Oberer Eselsberg 45, 889081 Ulm, Germany.
authors.forename: Andrea G
authors.initials: AG
authors.lastname: Ludolph
authors.forename: Freimut D
authors.initials: FD
authors.lastname: Juengling
authors.forename: Gerhard
authors.initials: G
authors.lastname: Libal
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
authors.forename: Jörg M
authors.initials: JM
authors.lastname: Fegert
authors.forename: Jan
authors.initials: J
authors.lastname: Kassubek
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002648:Child; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D005879:Tourette Syndrome / Q000473:pathology*; D014793:Visual Cortex / Q000473:pathology