Energy-converting [NiFe] hydrogenases: more than just H2 activation.
The well-characterized [NiFe] hydrogenases have a key function in the H2 metabolism of various microorganisms. A subfamily of the [NiFe] hydrogenases with unique properties has recently been identified. The six conserved subunits that build the core of these membrane-bound hydrogenases share sequence similarity with subunits that form the catalytic core of energy-conserving NADH:quinone oxidoreductases (complex I). The physiological role of some of these hydrogenases is to catalyze the reduction of H+ with electrons derived from reduced ferredoxins or polyferredoxins. This exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation. Other members of this hydrogenase subfamily mainly function in providing the cell with reduced ferredoxin using H2 as electron donor in a reaction driven by reverse electron transport. These hydrogenases have therefore been designated as energy-converting [NiFe] hydrogenases.
Hedderich
Reiner
R
Max-Planck-Institut für terrestrische Mikrobiologie, Marburg, Germany. hedderic@staff.uni-marburg.de
Forzi
Lucia
L
D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D042967:Electron Transport Complex I / Q000378:metabolism*; D004735:Energy Transfer; D006859:Hydrogen / Q000378:metabolism*; D006864:Hydrogenase / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism
D001426:Bacterial Proteins; D009097:Multienzyme Complexes; D006859:Hydrogen; D010088:Oxidoreductases; C043296:nickel-iron hydrogenase; D006864:Hydrogenase; C400203:Ech hydrogenase; D000445:Aldehyde Oxidoreductases; C019823:carbon monoxide dehydrogenase; D042967:Electron Transport Complex I