title: Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real-time PCR: correlation of CMV in the vagina and adverse outcome of pregnancy.
abstract: The impact of cytomegalovirus (CMV) infection of the genital tract during pregnancy on adverse pregnancy outcomes is not understood fully. A real-time PCR assay was used to determine vaginal shedding of CMV in 993 healthy pregnant Japanese women and the results were compared with the outcome of pregnancy. CMV DNA was detected in 76 (7.7%) of the women. The outcome of pregnancy could be determined finally in 848 women, of whom 60 (7.1%) were CMV positive. The carriers of CMV had an increased miscarriage rate (RR 6.96, 95% CI 2.04-23.84, P < 0.01). These findings suggest that latent genital tract CMV infection predisposes to adverse pregnancy outcomes.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Mashiho
authors.initials: M
authors.lastname: Minami
authors.forename: Soromon
authors.initials: S
authors.lastname: Kataoka
authors.forename: Kei
authors.initials: K
authors.lastname: Numazaki
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
mesh_terms: D000022:Abortion, Spontaneous / Q000821:virology; D000328:Adult; D003587:Cytomegalovirus / Q000235:genetics* / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011256:Pregnancy Outcome; D014621:Vagina / Q000821:virology*; D017201:Virus Shedding / Q000502:physiology*
chemical_list: D004279:DNA, Viral