title: Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure.
abstract: Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
authors.affiliation: Division of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Koyama
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ogita
authors.forename: Tateki
authors.initials: T
authors.lastname: Tsutsui
authors.forename: Koichiro
authors.initials: K
authors.lastname: Shimoya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Masayasu
authors.initials: M
authors.lastname: Koyama
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kaneda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D010064:Embryo Implantation; D020964:Embryo Loss / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007246:Infertility / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D050796:STAT3 Transcription Factor