Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.
Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
Biot
Christophe
C
Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652 Villeneuve d' Ascq Cedex, France. christophe.biot@ensc-lille.fr
Daher
Wassim
W
Chavain
Natascha
N
Fandeur
Thierry
T
Khalife
Jamal
J
Dive
Daniel
D
De Clercq
Erik
E
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D015195:Drug Design; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects
D000962:Antimalarials; D000998:Antiviral Agents; D005296:Ferrous Compounds; D011804:Quinolines