Proteome analysis to study signal transduction of G protein-coupled receptors.
G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR.
Pluder
Franka
F
Institute of Biochemistry, University of Leipzig, Brüderstrasse 34, D-04103, Leipzig, Germany.
Mörl
Karin
K
Beck-Sickinger
Annette G
AG
D000818:Animals; D006801:Humans; D040081:Protein Array Analysis; D040901:Proteomics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
D043562:Receptors, G-Protein-Coupled