[Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors].
BACKGROUND
To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.


METHODS
The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).


RESULTS
The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.


CONCLUSIONS
Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.
Wang
Shu-xiang
SX
AIDS Research Center, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Shang
Hong
H
Han
Xiao-xu
XX
Zhang
Zi-ning
ZN
Wang
Ya-nan
YN
Zhang
Min
M
Jiang
Yong-jun
YJ
Liu
Jing
J
Su
Yan-li
YL
D054377:Chemokine CXCL12 / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D054390:Receptors, CCR2 / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics; D015728:Receptors, HIV / Q000235:genetics*
D054377:Chemokine CXCL12; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D015728:Receptors, HIV