[Influences of orthodontic tooth movement on estrous cycle and estrogen in rats].
OBJECTIVE
To explore the influences of orthodontic tooth movement on estrous cycle and estrogen in female rats.


METHODS
Two hundred female rats were divided into control group, one-time activation group, four-time activation group and sham-operated group. Each group was divided again into 4 sub-groups according to the different stage of the estrous cycle. The force-loading groups received repeated intermittent force. Serum estrogen was measured and the change of estrous cycle was recorded.


RESULTS
There were significant variations in the estrogen level among the groups which received mechanical force during the same stage of the estrous cycle (P < 0.01) and among the subgroups within each group (P < 0.05). These experimental treatments affected the estrous cycle of the rats in the groups received force in metestrus and diestrus.


CONCLUSIONS
Estrus of rats was the appropriate time for the orthodontic force.
Zhao
Qing
Q
Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Tan
Zhen
Z
Guo
Jie
J
Chen
Yang-xi
YX
D000818:Animals; D004967:Estrogens / Q000097:blood*; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
D004967:Estrogens