[Expression of NF-kappaB/IkappaB signal pathway in renal tissues of hepatitis B virus-associated nephritis].
OBJECTIVE
To investigate the expression of nuclear transcription factor-kappa B (NF-kappaB)/IkappaB in renal tissues of hepatitis B virus-associated nephritis (HBVGN) and to study its role in the pathogenesis of HBVGN.


METHODS
The expression of NF-kappaB p65 and IkappaB-alpha in renal tissues was examined in biopsy specimens from 42 HBVGN patients, 20 patients with primary membranous nephropathy and 5 normal subjects by immunohistochemical staining.


RESULTS
The NF-kappaB p65 expression in glomerular and tubular of HBVGN tissues was notably higher than that in normal control tissues (P<0.05) and in primary membranous nephropathy tissues (P<0.01). The IkappaB-alpha expression in glomerular and tubular of HBVGN tissues was lower than that in primary membranous nephropathy tissues (P<0.05).


CONCLUSIONS
There might be protein degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in renal tissues of HBVGN, which suggests that NF-kappaB/IkappaB signal pathway may play an important role in the pathogenesis of HBVGN.
Yu
Yan
Y
Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Wang
Han-min
HM
Zhang
Jing
J
Chen
Wei
W
Cui
Ji-hong
JH
Liu
Yan-fang
YF
Lian
Yao-guo
YG
D000293:Adolescent; D000328:Adult; D005260:Female; D015870:Gene Expression; D050533:Glomerular Basement Membrane / Q000378:metabolism*; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000472:pathogenicity; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000378:metabolism*; D009393:Nephritis / Q000209:etiology / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction / Q000502:physiology*; D051996:Transcription Factor RelA / Q000378:metabolism*; D055815:Young Adult
D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D051996:Transcription Factor RelA; D000072000:NF-KappaB Inhibitor alpha