The effect of mosapride on esophageal motility and bolus transit in asymptomatic volunteers.
OBJECTIVE
To evaluate the effect of mosapride, a selective 5-hydroxytryptamine-4 agonist, on esophageal motility and bolus transit in asymptomatic volunteers.


METHODS
Twenty healthy subjects participated in two experiments, 7 days apart, and we utilized a randomized, double-blind cross-over design with 3-day pretreatments of placebo or mosapride. All subjects underwent combined intraluminal impedance manometry.


RESULTS
There was no difference in the amplitude, the duration, and the esophageal peristaltic patterns between the two pretreatments. The lower esophageal sphincter (LES) pressure and the number of transient LES relaxations did not change after mosapride vs. placebo. However, the rate of complete bolus transit in liquid swallows was higher with mosapride pretreatment (92.2%) than with placebo (84.6%; P < 0.01). The total bolus transit time in all liquid swallows showed a tendency to shorten after mosapride treatment (P = 0.06). The liquid bolus transit became faster after mosapride, especially in manometrically ineffective liquid swallows (P < 0.01). The total bolus transit time for manometrically normal viscous swallows decreased after pretreatment with mosapride (7.7 seconds; range, 6.8-9.2) in comparison with placebo (8.1 seconds; range, 7.1-11.1; P < 0.05).


CONCLUSIONS
Mosapride increases the rate of complete bolus transit in the esophagus, and enhances esophageal bolus transit in asymptomatic volunteers.
Cho
Yu Kyung
YK
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Choi
Myung-Gyu
MG
Han
Hae Won
HW
Park
Jae Myung
JM
Oh
Jung Hwan
JH
Jeong
Jeong Jo
JJ
Cho
Young Seok
YS
Lee
In Seok
IS
Kim
Sang Woo
SW
Choi
Kyu Yong
KY
Chung
In-Sik
IS
D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D004311:Double-Blind Method; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008297:Male; D008365:Manometry; D009025:Morpholines / Q000494:pharmacology*; D011312:Pressure
D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; C062720:mosapride