Oral, post-oral and genetic interactions in sweet appetite.
Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite.
Sclafani
Anthony
A
Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, USA. Asclafani@gc.cuny.edu
D000818:Animals; D001069:Appetite Regulation / Q000235:genetics / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009055:Mouth / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D012054:Reinforcement, Psychology; D013045:Species Specificity; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013649:Taste / Q000235:genetics / Q000502:physiology*
D043562:Receptors, G-Protein-Coupled; D013549:Sweetening Agents; C431926:taste receptors, type 1; D013395:Sucrose