title: Pattern of increased cerebral FDG uptake in Down syndrome patients.
abstract: Resting cerebral glucose metabolism was assessed by 18[F]-fluorodeoxyglucose in 11 Down syndrome patients. Standardized uptake values were determined on a pixel-by-pixel basis from the measured tissue-activity data. The results revealed a mean overall 18[F]-fluorodeoxyglucose uptake in the Down syndrome patients close to that observed in the control group, consisting of children and young adults. However, the standard deviation of the standardized uptake values was much higher in the Down syndrome group in almost all voxels relating to the gray matter. The statistical parametric mapping method was applied to compare the cerebral 18[F]-fluorodeoxyglucose accumulation patterns of the Down syndrome and control groups. Six regions (clusters) were found for which the glucose uptake was higher in the Down syndrome patients than in the control group. The anatomic localization of these clusters was based on magnetic resonance investigations and a brain-atlas technique. The localization of the identified clusters with an increased glucose metabolism in the Down syndrome patients suggests that these subjects have an enhanced resting neuronal activity in cortical areas involved in reasoning, cognition, and speech as compared with normal subjects.
authors.affiliation: PET Centre, Debrecen University, Debrecen, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lengyel
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Balogh
authors.forename: Miklós
authors.initials: M
authors.lastname: Emri
authors.forename: Edit
authors.initials: E
authors.lastname: Szikszai
authors.forename: József
authors.initials: J
authors.lastname: Kollár
authors.forename: Judit
authors.initials: J
authors.lastname: Sikula
authors.forename: Olga
authors.initials: O
authors.lastname: Esik
authors.forename: Lajos
authors.initials: L
authors.lastname: Trón
authors.forename: Eva
authors.initials: E
authors.lastname: Oláh
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012146:Rest / Q000502:physiology; D013687:Telencephalon / Q000000981:diagnostic imaging / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose