Preprocedural statin use is associated with a reduced hazard of postprocedural myonecrosis in patients undergoing rotational atherectomy--a propensity-adjusted analysis.
Incidence of myonecrosis in patients undergoing rotational atherectomy was evaluated by preprocedural statin use. The incidence of any myonecrosis (24.1% vs 52.3%, P < .001) or significant myonecrosis (7.5% vs 21.8%, P < .001) was significantly lower among patients pretreated with statins. This difference remained significant after multivariable and propensity adjustment.
Gurm
Hitinder S
HS
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA. hgurm@med.umich.edu
Breitbart
Yuri
Y
Vivekanathan
Deepak
D
Yen
Michael H
MH
Fathi
Robert
R
Ziada
Khaled M
KM
Whitlow
Patrick L
PL
Ellis
Stephen G
SG
D000368:Aged; D017225:Atherectomy, Coronary / Q000009:adverse effects; D009202:Cardiomyopathies / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003327:Coronary Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000453:epidemiology / Q000517:prevention & control; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D012720:Severity of Illness Index
D002316:Cardiotonic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex