[Simultaneous liver-pancreas-duodenum transplantation: one case report and review of the literature].
OBJECTIVE
To investigate the effect of treatment on end-stage liver disease and type-I diabetes mellitus with simultaneous liver-pancreas-duodenum transplantation.


METHODS
In September 2003, one patient with chronic hepatitis B, liver cirrhosis, hepatic cellular cancer, and insulin-dependent diabetes received simultaneous orthotopic liver and heterotopic pancreas-duodenum transplantation. Liver and pancreas graft function was monitored after transplantation.


RESULTS
The function of pancreas allograft was recovered immediately and the patient became insulin-independence postoperatively. The liver allograft was experienced an acute rejection episode and reversed by intravenous bolus methylprednisolone. The recipient was currently liver disease-free and insulin-free more than 21 months.


CONCLUSIONS
The simultaneous liver-pancreas-duodenum transplantation is an effective method in the treatment of end-stage liver disease and type-I diabetes mellitus.
Xu
Jian
J
Department of Organ Transplantation, Nanfang Hospital, The Southern Medical University, Guangzhou 510515, China. Xujian@fimmu.com
Yu
Li-xin
LX
Deng
Wen-feng
WF
Fu
Shao-jie
SJ
Du
Chuan-fu
CF
Wang
Yi-bin
YB
Liu
Xiao-you
XY
Miao
Yun
Y
Li
Chuan-jiang
CJ
Ye
Jun-sheng
JS
D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000601:surgery*; D004386:Duodenum / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents