Acute behavioural stress facilitates long-term depression in temporoammonic-CA1 pathway.
Behavioural stress facilitates long-term depression in Schaffer collaterals-CA1 pathway, but it is unknown whether it influences long-term depression in temporoammonic fibres-CA1. Here, we report that low-frequency stimulation induced long-term depression and foot shock stress before slice preparation facilitated long-term depression in both pathways of young rat slices. When the field excitatory postsynaptic potentials were recorded by stimulating the two pathways alternately and low-frequency stimulation was given to the two pathways simultaneously, a reliable long-term depression was induced in Schaffer collaterals-CA1 but a reliable long-term potentiation took place in temporoammonic fibres-CA1. Interestingly, foot shock stress now enabled low-frequency stimulation to induce reliable long-term depressions in both pathways. These findings suggested that acute behavioural stress facilitated long-term depressions in both pathways and disrupted the interactions between pathways.
Yang
Jianli
J
Mental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha, PR China.
Han
Huili
H
Cui
Minghu
M
Wang
Liping
L
Cao
Jun
J
Li
Lingjiang
L
Xu
Lin
L
D000818:Animals; D001522:Behavior, Animal; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004597:Electroshock / Q000009:adverse effects; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology / Q000528:radiation effects; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D066298:In Vitro Techniques; D036881:Long-Term Synaptic Depression / Q000502:physiology* / Q000528:radiation effects; D009434:Neural Pathways / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology*