title: Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma.
abstract: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.
authors.affiliation: Clinical Research Institute, National Hospital Organization, Osaka National Hospital, Chuo-ku, Osaka, Japan. misuzu_s@wakayama2.hosp.go.jp
authors.forename: Misuzu
authors.initials: M
authors.lastname: Shimakage
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Inoue
authors.forename: Kohichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Kunimitsu
authors.initials: K
authors.lastname: Kawahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Oka
authors.forename: Kazuta
authors.initials: K
authors.lastname: Yasui
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Inoue
authors.forename: Akihiro
authors.initials: A
authors.lastname: Watari
authors.forename: Shinji
authors.initials: S
authors.lastname: Higashiyama
authors.forename: Masuo
authors.initials: M
authors.lastname: Yutsudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D015536:Down-Regulation / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016356:Gene Products, tax / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009185:Myelin Proteins / Q000235:genetics*; D000070798:Nogo Proteins; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D016356:Gene Products, tax; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009185:Myelin Proteins; D000070798:Nogo Proteins; D012333:RNA, Messenger; C000603199:RTN4 protein, human