title: Hiv prevalence among high risk behavior group persons with herpes zoster infection.
abstract: The aim of the two year (2003-2005) study was to study the HIV prevalence among high risk behavior groups of persons with Herpes Zoster infection. For this purpose we have investigated the high risk group patients: 1257 prisoners (1st group), 1543 IDUs (2nd group) and 1350 persons including: homosexuals, persons with history of frequent unprotected sex and persons with hepatitis B and C (3rd group). We revealed the persons with current or previous history of Herpes Zoster, and studied HIV prevalence among them. Besides, we have studied the immune status of revealed HIV positive persons, relationship between disease (Herpes Zoster) severity and CD4 count. Herpes Zoster infection was diagnosed based on clinical symptoms, anamnesis and by detection of VZV specific IgM and IgG by ELISA. HIV infection was diagnosed by ELISA method and was confirmed by Western Blot. CD4 count was detected by immunophenotyping technique and was analyzed using a FACSCalibur flow cytometer. The total prevalence of HIV infection among high risk behavior group persons with Herpes Zoster infection was 18,9% (31 HIV cases out of 164). The disease (Herpes Zoster) severity and duration was associated with decreased rate of cellular immunity, CD4 count. Herpes Zoster has a positive predictive value for HIV infection, predominantly recurrent Herpes Zoster. Herpes Zoster should be recognized as a marker condition indicating the necessity of screening for HIV, especially in Georgia, the region where the problem of IDU exists.
authors.affiliation: Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Sharvadze
authors.forename: T
authors.initials: T
authors.lastname: Tsertsvadze
authors.forename: N
authors.initials: N
authors.lastname: Gochitashvili
authors.forename: K
authors.initials: K
authors.lastname: Stvilia
authors.forename: E
authors.initials: E
authors.lastname: Dolmazashvili
mesh_terms: D015658:HIV Infections / Q000453:epidemiology*; D006562:Herpes Zoster / Q000453:epidemiology*; D006801:Humans; D015995:Prevalence; D011329:Prisoners / Q000706:statistics & numerical data*; D012309:Risk-Taking