title: Autologous platelet concentrate and vacuum-assisted closure device use in a nonhealing total knee replacement.
abstract: Following a total knee replacement surgery, a 51-year-old insulin-dependent patient presented with complications of impaired healing and postoperative trauma to the wound site. The inability of this leg wound to heal placed this patient at risk of amputation. Vacuum-assisted closure therapy was initiated at postoperative day 53; after 100 days of protracted wound history a series of treatments with topical platelet concentrates were added to the vacuum assisted closure therapy and conventional wound care therapy. The previous nonhealing wound presented with good granulation and margination that enabled a skin graft with good take on postoperative day 150.
authors.affiliation: Department of Perfusion Services,Surgery, Geisinger Medical Center, Danville, Pennsylvania 17822, USA. mklayman@geisinger.edu
authors.forename: Myra H
authors.initials: MH
authors.lastname: Klayman
authors.forename: Cody C
authors.initials: CC
authors.lastname: Trowbridge
authors.forename: Alfred H
authors.initials: AH
authors.lastname: Stammers
authors.forename: Gary L
authors.initials: GL
authors.lastname: Wolfgang
authors.forename: David A
authors.initials: DA
authors.lastname: Zijerdi
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Bitterly
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001792:Blood Platelets / Q000166:cytology*; D002469:Cell Separation; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005782:Gels / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010976:Platelet Count; D016038:Skin Transplantation; D013530:Surgical Wound Infection / Q000150:complications*; D014619:Vacuum Curettage; D014945:Wound Healing
chemical_list: D005782:Gels