title: Azobenzene as conformational switch in model peptides.
abstract: The photoinduced isomerization of azobenzene between the extended (trans) and compact (cis) conformations is reversibly triggered by light of two differing wavelengths. The resulting changes in molecular geometry have been extensively utilized to photoswitch transformations in chemical species reversibly for applications in optoelectronic devises as well as to photocontrol conformational states in (bio)polymers. The high isomerization yield, remarkable photostability and ultrafast kinetics (few ps) of azobenzene are well suited for the design of small, defined model systems that allow detailed folding studies to be carried out both experimentally and theoretically on the same molecules. In our and other laboratories such systems were recently obtained with cyclic peptides of defined conformational preferences as well as with alpha-helical and beta-hairpin peptides. These should, by comparison of simulation and experiment, permit an assessment and improvement of the theoretical description on the one hand and a detailed interpretation of the ultrafast conformational dynamics on the other. The phototriggered changes in conformational states lead to concurrent changes in biophysical properties that can be exploited in the photocontrol of biochemical and biological events, as exemplarily discussed with redox-active cyclic bis-cysteinyl peptides and receptor ligands.
authors.affiliation: School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, NG11 8NS, UK. christian.renner@ntu.ac.uk
authors.forename: Christian
authors.initials: C
authors.lastname: Renner
authors.forename: Luis
authors.initials: L
authors.lastname: Moroder
mesh_terms: D001391:Azo Compounds / Q000737:chemistry* / Q000528:radiation effects*; D002863:Chromogenic Compounds / Q000737:chemistry; D008027:Light; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation / Q000528:radiation effects; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; D002863:Chromogenic Compounds; D010455:Peptides; C009850:azobenzene