title: Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris.
abstract: This study examined whether coronary focal vasospasm occurs in a nonuniform distribution within the coronary tree and whether a longitudinal plaque distribution pattern is present in patients with vasospastic angina using 3-dimensional intravascular ultrasound analysis. Of 121 patients with clinically suspected angina without fixed stenosis in the coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection. Most focal vasospasms occurred in the proximal third of the coronary arteries (proximal 28, mid 8, distal 6, p <0.01), corresponding to the historical high-risk zones for acute coronary occlusion. More plaque burden also existed in the proximal third of the coronary arteries in patients with focal vasospasm.
authors.affiliation: Center for Research in Cardiovascular Interventions, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Koizumi
authors.forename: Masaki
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Susumu
authors.initials: S
authors.lastname: Namikawa
authors.forename: Nehiro
authors.initials: N
authors.lastname: Kuriyama
authors.forename: Mizuo
authors.initials: M
authors.lastname: Nameki
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneda
authors.forename: Krishnankutty
authors.initials: K
authors.lastname: Sudhir
authors.forename: Paul G
authors.initials: PG
authors.lastname: Yock
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Komiyama
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fitzgerald
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004562:Electrocardiography; D004874:Ergonovine; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018084:Ultrasonography, Interventional; D014662:Vasoconstrictor Agents
chemical_list: D014662:Vasoconstrictor Agents; D004874:Ergonovine