title: Study on the ophthalmic diseases in ICR mice and BALB/c mice.
abstract: In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.
authors.affiliation: Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea.
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Park
authors.forename: Seong Mok
authors.initials: SM
authors.lastname: Jeong
authors.forename: Na Young
authors.initials: NY
authors.lastname: Yi
authors.forename: Min Su
authors.initials: MS
authors.lastname: Kim
authors.forename: Man Bok
authors.initials: MB
authors.lastname: Jeong
authors.forename: Jun Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Yang Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Tchi Chou
authors.initials: TC
authors.lastname: Nam
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Park
authors.forename: Kang Moon
authors.initials: KM
authors.lastname: Seo
mesh_terms: D000818:Animals; D005128:Eye Diseases / Q000453:epidemiology / Q000662:veterinary*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D012376:Rodent Diseases / Q000453:epidemiology