[Effects of intracoronary autologous bone marrow mononuclear cells transplantation in patients with anterior myocardial infarction].
OBJECTIVE
To investigate the efficacy of intracoronary transfer of autologous bone marrow mononuclear cells (ABMMNCs) to patients with myocardial infarction (MI) on left ventricular function and myocardial perfusion.


METHODS
Thirty-five patients with MI (> 4 weeks) were enrolled in this prospective, open-labeled study (20 patients in cell transplantation group; 15 patients in control group). All patients were treated by standard drug therapy and percutaneous coronary intervention (PCI). Baseline and 3 months follow-up evaluations included complete clinical and laboratory examinations, six minutes walk test, echocardiography, Dual-isotope simultaneous acquisition single photon emission computed tomography (DISA-SPECT) and cardiac magnetic resonance imaging (MRI).


RESULTS
Baseline parameters were similar between the two groups. NYHA classification and six minutes walk test at 3 months follow-up were also similar between the two groups. However, left ventricular ejection fraction (LVEF) determined by echocardiography and DISA-SPECT was significantly higher; regional wall motion measured by echocardiography and cardiac MRI, myocardial viability and myocardial perfusion in the infarct zone assessed by DISA-SPECT were all significantly improved than before transplantation and than that in control group at 3 months follow-up.


CONCLUSIONS
Our results indicate that intracoronary transplantation of ABMMNCs could improve the left ventricular systolic function and beneficially affect myocardial perfusion up to 3 months post transplantation in patients with myocardial infarction.
Wang
Wei-min
WM
Cardiology Department, People's Hospital Peking University, Beijing 100044, China.
Sun
Ning-ling
NL
Liu
Jian
J
Zhang
Ping
P
Liu
Kai-yan
KY
Wang
Qian
Q
Yang
Song-na
SN
Wang
Su-qin
SQ
Zang
Yue
Y
Guo
Ji-hong
JH
D016026:Bone Marrow Transplantation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D009203:Myocardial Infarction / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left