Mouse models of gastrointestinal tumors.
The laboratory mouse (Mus musculus) has become one of the best model animal species in biomedical research today because of its abundant genetic/genomic information, and easy mutagenesis using transgenic and gene knockout technology. Genetically engineered mice have become essential tools in both mechanistic studies and drug development. In this article I will review recent topics in gastrointestinal cancer model mice, with emphasis on the results obtained in our laboratory. They include: (i) mouse models for familial adenomatous polyposis (Apc mutant mice; modifier genes of Apc intestinal polyposis; stabilizing beta-catenin mutant mice); (ii) mouse models for colon cancer (mouse models for hereditary non-polyposis colon cancer; additional mutations in Apc mutant mice; models with mutations in other genes; models for colon cancer associated with inflammatory bowel diseases); and (iii) mouse models for gastric cancer.
Taketo
Makoto Mark
MM
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo, Kyoto 606-8501, Japan. taketo@mfour.med.kyoto-u.ac.jp
D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000378:metabolism; D051379:Mice / Q000235:genetics*; D008954:Models, Biological; D009154:Mutation; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D025601:Adenomatous Polyposis Coli Protein; D051176:beta Catenin