title: Cortical modulation of dorsal column nuclei: a computational study.
abstract: We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.
authors.affiliation: Grupo de Sistemas Intelixentes (GSI), Departamento de Electrónica e computación, Facultade de Físicas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. eduardos@usc.es
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sánchez
authors.forename: Senén
authors.initials: S
authors.lastname: Barro
authors.forename: Jorge
authors.initials: J
authors.lastname: Mariño
authors.forename: Antonio
authors.initials: A
authors.lastname: Canedo
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D008564:Membrane Potentials / Q000502:physiology / Q000528:radiation effects; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology*; D013116:Spinal Cord / Q000166:cytology*; D013569:Synapses / Q000502:physiology