Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women.
Replication capacity and transmission of human immunodeficiency virus (HIV)-1 in antiretroviral drug-naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV-1 and in 47 women whose infants were uninfected by 6-8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters (P=.01). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11-1.90]; P = .0063), after adjustment for maternal HIV-1 load and other factors.
Eshleman
Susan H
SH
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. seshlem@jhmi.edu
Lie
Yolanda
Y
Hoover
Donald R
DR
Chen
Shu
S
Hudelson
Sarah E
SE
Fiscus
Susan A
SA
Petropoulos
Christos J
CJ
Kumwenda
Newton
N
Parkin
Neil
N
Taha
Taha E
TE
D000328:Adult; D002460:Cell Line; D005260:Female; D017930:Genes, Reporter; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008156:Luciferases / Q000032:analysis / Q000235:genetics; D008295:Malawi; D009035:Mothers; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013223:Statistics as Topic; D014779:Virus Replication
D008156:Luciferases