Serum amyloid a protein as a predictor of cardiac rupture in acute myocardial infarction patients following primary coronary angioplasty.
BACKGROUND
The predictors of cardiac rupture (CR) in patients with acute myocardial infarction (AMI) treated with successful primary coronary angioplasty have not been identified.


RESULTS
Of 433 consecutive AMI subjects who underwent reperfusion by primary coronary angioplasty within 24 h of onset, CR occurred in 11 (2.5%), free wall rupture in 9, and ventricular septal perforation in 2. Rates of females, diabetes mellitus and anterior infarction were higher in the group of CR patients than in the others (p < 0.05). There were no significant differences between the 2 groups in terms of left ventricular (LV) function soon after recanalization, such as LV ejection fraction, regional wall motion, or end-diastolic volume index. Plasma levels of both high-sensitivity C-reactive protein (hsCRP) and serum amyloid-A protein (SAA) were significantly higher in the CR patients than in the others (hsCRP: 6.7 +/- 6.7 mg/dl vs 3.3 +/- 3.8 mg/dl, p = 0.007; SAA: 699 +/- 812 microg/dl vs 208 +/- 273 microg/dl, p < 0.0001). Multivariate analysis identified SAA as an independent predictor of CR (risk ratio: 8.8, 95% confidence interval: 1.7-25.6, p < 0.05). Conclusions In patients with AMI treated with primary coronary angioplasty, inflammation may be closely related to CR, for which SAA is a useful predictor.
Katayama
Toshiro
T
Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan. snowman-kt@syd.odn.ne.jp
Nakashima
Hiroshi
H
Takagi
Chisa
C
Honda
Yukiharu
Y
Suzuki
Shin
S
Iwasaki
Yoshihiro
Y
Yamamoto
Tadashi
T
Yoshioka
Masato
M
Yano
Katsusuke
K
D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000097:blood*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D005260:Female; D006341:Heart Rupture / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
D000682:Amyloid