title: Disorders of menstruation and their effect on the quality of life in women with congenital factor VII deficiency.
abstract: OBJECTIVE
  To review menstrual problems in women with congenital FVII deficiency and to study their effect on the quality of life during menstruation in women with congenital FVII deficiency.
  
  
  METHODS
  14 women with congenital factor VII deficiency registered with the Haemophilia Centre at the Royal Free Hospital were interviewed and their case notes reviewed. All women completed Pictorial Blood assessment Chart (PBAC) for assessment of menstrual blood loss and a quality of life questionnaire during menstruation. Similar questionnaire and PBAC was completed by an age matched healthy control group of 23 women.
  
  
  RESULTS
  Median age of study group was 35 yrs and of control group 34 yrs. Median FVII level of the study group was 31.5 IU/dL Two women had severe FVII deficiency (FVII level < 10 IU/dL) and 12 women had mild-moderate FVII deficiency. 57% women (8/14) from study group had menorrhagia (PBAC score > 100) compared with 17% (4/23) women from the control group. Six women (43%) from the study group were diagnosed with anaemia due to heavy periods, compared to two (9%) in the control group. The quality of life scores during menstruation were significantly worse in the women with FVII deficiency, compared to controls.
  
  
  CONCLUSIONS
  Women with factor VII deficiency exhibit a spectrum of bleeding symptoms, menorrhagia being one of the commonest symptoms. This has adverse effect on their quality of life.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK. winikulkarni@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Kulkarni
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Griffeon
authors.forename: R A
authors.initials: RA
authors.lastname: Kadir
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D004412:Dysmenorrhea / Q000150:complications / Q000503:physiopathology; D015444:Exercise / Q000502:physiology; D005167:Factor VII / Q000032:analysis; D005168:Factor VII Deficiency / Q000150:complications / Q000151:congenital* / Q000503:physiopathology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008595:Menorrhagia / Q000150:complications; D008598:Menstruation / Q000502:physiology; D008599:Menstruation Disturbances / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D011788:Quality of Life
chemical_list: D006454:Hemoglobins; D005167:Factor VII