The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis.
OBJECTIVE
Chronic pancreatitis (CP) is an inflammatory process initiated by recurrent acute pancreatitis and characterized by progressive parenchyma destruction and fibrosis. Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP.


METHODS
A genetic association study was performed on 177 CP patients and 116 healthy controls from the NAPS2 Study. The MCP-1 A/G genotype was determined by RFLP and confirmed by DNA sequencing.


RESULTS
Compared to the control group the MCP-1 -2518 genotypes were similar: A/A (57% vs. 50%), A/G (34.5% vs. 40%) and G/G (8.5% vs. 10%). These allele frequencies were not statistically different (p = 0.267).


CONCLUSIONS
Although the pro-inflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP.
Sass
David A
DA
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Papachristou
Georgios I
GI
Lamb
Janette
J
Barmada
M Michael
MM
Brand
Randall E
RE
Money
Mary E
ME
Hawes
Robert H
RH
Cotton
Peter B
PB
Slivka
Adam
A
Whitcomb
David C
DC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000235:genetics*; D011110:Polymorphism, Genetic
D018932:Chemokine CCL2