title: Is cartilage thickness different in young subjects with and without patellofemoral pain?
abstract: OBJECTIVE
  To determine the differences in load-bearing patellofemoral joint cartilage thickness between genders. To determine the differences in load-bearing cartilage thickness between pain-free controls and individuals with patellofemoral pain.
  
  
  METHODS
  The articular cartilage thickness of the patella and anterior femur was estimated from magnetic resonance images in 16 young, pain-free control subjects (eight males, eight females) and 34 young individuals with patellofemoral pain (12 males, 22 females). The average age of all subjects was 28+/-4 years. The cartilage surfaces were divided into regions approximating the location of patellofemoral joint contact during knee flexion. The mean and peak cartilage thicknesses of each region were computed and compared using a repeated-measures Analysis of Variance.
  
  
  RESULTS
  On average, males had 22% and 23% thicker cartilage than females in the patella (P < 0.01) and femur (P < 0.05), respectively. Male control subjects had 18% greater peak patellar cartilage thickness than males with patellofemoral pain (P < 0.05); however, we did not detect differences in patellar cartilage thickness between female control subjects and females with patellofemoral pain (P = 0.45). We detected no significant differences in femoral cartilage thickness between the control and pain groups.
  
  
  CONCLUSIONS
  Thin cartilage at the patella may be one mechanism of patellofemoral pain in male subjects, but is unlikely to be a dominant factor in the development of pain in the female population.
authors.affiliation: Department of Mechanical Engineering, Stanford University, James H. Clark Center, Stanford, CA 94305, USA. cdraper@stanford.edu
authors.forename: C E
authors.initials: CE
authors.lastname: Draper
authors.forename: T F
authors.initials: TF
authors.lastname: Besier
authors.forename: G E
authors.initials: GE
authors.lastname: Gold
authors.forename: M
authors.initials: M
authors.lastname: Fredericson
authors.forename: A
authors.initials: A
authors.lastname: Fiene
authors.forename: G S
authors.initials: GS
authors.lastname: Beaupre
authors.forename: S L
authors.initials: SL
authors.lastname: Delp
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007592:Joint Diseases / Q000473:pathology*; D007719:Knee Joint / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D010146:Pain / Q000473:pathology*; D012737:Sex Factors