title: Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains.
abstract: The ability to cope with ongoing neurodegeneration after injury to the central nervous system of mammals differs among strains and depends in part on the animal's ability to manifest a T-cell-mediated protective response. After CNS injury, strain-related differences were observed. Moreover, the post-injury effect of naturally occurring regulatory CD4+CD25+ T cells was found to differ in different strains. In this study, using partially injured optic nerves of Balb/c/OLA and C57BL/6J mice as models, we observed strain-related differences in the T-cell-mediated protection obtained by antigens administered via the nasal route. Active immunization with myelin-related antigens emulsified in complete Freund's adjuvant had a beneficial effect on both strains, whereas mucosal administration of the same antigens was destructive in mice of the Balb/c/OLA strain but protective in C57BL/6J mice.
authors.affiliation: Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.
authors.forename: Gil M
authors.initials: GM
authors.lastname: Lewitus
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kipnis
authors.forename: Hila
authors.initials: H
authors.lastname: Avidan
authors.forename: Avraham
authors.initials: A
authors.lastname: Ben-Nun
authors.forename: Michal
authors.initials: M
authors.lastname: Schwartz
mesh_terms: D000281:Administration, Intranasal; D000595:Amino Acid Sequence; D000818:Animals; D002470:Cell Survival / Q000235:genetics; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D018984:Epitopes, T-Lymphocyte / Q000008:administration & dosage / Q000235:genetics / Q000502:physiology*; D007108:Immune Tolerance / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology*; D009410:Nerve Degeneration / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control*; D020221:Optic Nerve Injuries / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018984:Epitopes, T-Lymphocyte