Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy.
The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
Lodi
R
R
Dipartimento di Medicina Clinica e Biotecnologia Applicata, Policlinico S. Orsola-Malpighi, Università di Bologna, Italy. raffaele.lodi@unibo.it
Pierangeli
G
G
Tonon
C
C
Cevoli
S
S
Testa
C
C
Bivona
G
G
Magnifico
F
F
Cortelli
P
P
Montagna
P
P
Barbiroli
B
B
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D003027:Cluster Headache / Q000378:metabolism* / Q000473:pathology; D003401:Creatine / Q000037:antagonists & inhibitors / Q000378:metabolism; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009778:Occipital Lobe / Q000378:metabolism / Q000473:pathology; D010296:Parietal Lobe / Q000378:metabolism / Q000473:pathology; D011522:Protons
D015415:Biomarkers; D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine