title: Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline.
abstract: BACKGROUND
  Neurocognitive decline after cardiac surgery requiring cardiopulmonary bypass (CPB) may be caused in part by highly prothrombotic atheroemboli to the brain; the source of these emboli is likely the ascending aorta and aortic arch. We examined transcerebral platelet activation gradients using simultaneous measurements in arterial and jugular venous blood and then compared gradients with post-CPB-associated neurocognitive injury.
  
  
  METHODS
  Eighty-one patients undergoing elective coronary artery bypass graft surgery requiring CPB were studied. Neurocognitive function was measured preoperatively and again at 6 weeks postoperatively. Paired arterial and jugular venous blood samples were drawn before surgery, immediately before and after aortic cross-clamp removal (an event previously linked to embolic showers), and at the end of the operation. Transcerebral platelet activation gradients (venous minus arterial values) were compared in patients with and without cognitive deficit.
  
  
  RESULTS
  Immediately after aortic cross-clamp removal, there was a significant increase in the transcerebral platelet activation gradient (increased % P-selectin-positive platelets during transcerebral passage) in the subset of patients who subsequently developed post-CPB cognitive deficit; this platelet activation gradient did not occur in patients without cognitive injury. In contrast, there was no transcerebral gradient of platelet activation in CPB patients as an entirety, nor was there a gradient at all other time points in the patient subset who went on to have cognitive deficit develop. This fleeting gradient of transcerebral platelet activation after cross-clamp removal was also significantly correlated with the overall change in cognitive injury score.
  
  
  CONCLUSIONS
  Transient intracerebral platelet activation after removal of the aortic cross-clamp is associated with post-CPB neurocognitive injury.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Mathew
authors.forename: Henry M
authors.initials: HM
authors.lastname: Rinder
authors.forename: Brian R
authors.initials: BR
authors.lastname: Smith
authors.forename: Mark F
authors.initials: MF
authors.lastname: Newman
authors.forename: Christine S
authors.initials: CS
authors.lastname: Rinder
mesh_terms: D000368:Aged; D001921:Brain / Q000502:physiology*; D002315:Cardiopulmonary Bypass; D018946:Chemokine CCL5; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D011446:Prospective Studies
chemical_list: D018946:Chemokine CCL5; D019007:P-Selectin