title: Timing of restorative proctectomy following subtotal colectomy in patients with inflammatory bowel disease.
abstract: BACKGROUND
  There is no general consensus regarding the timing of restorative proctocolectomy (RPC) in patients who have undergone subtotal colectomy with end ileostomy (STC). The aim of this study was to determine the impact of timing of RPC in patients who have undergone subtotal colectomy and end ileostomy for inflammatory bowel disease (IBD).
  
  
  METHODS
  A retrospective medical record review of patients who had undergone RPC after STC was undertaken. Patients were divided into 3 groups according to timing of the completion proctectomy: <or= 3 months, 4-7 months and > 7 months.
  
  
  RESULTS
  From 1990 to 2000, 91 patients had undergone RPC after STC for IBD. There were no statistically significant differences among the three groups relative to mean age, gender, final diagnosis, duration of disease, body mass index, comorbidity, extraintestinal manifestations, use of immunuosuppressives, or operative time. The number of intra-operative complications were significantly higher in the <or= 3 month group compared to the other groups. There was no significant difference in the overall incidence of postoperative complications among the 3 groups. Postoperative fistulas were significantly more common after RPC in Groups 1 and 2 as compared to Group 3.
  
  
  CONCLUSIONS
  Restorative proctocolectomy performed within 3 months after the initial subtotal colectomy was associated with a significant increase in the incidence of intra-operative complications. Although this increase was not statistically significant, there was a significantly higher incidence of fistula formation when RPC was undertaken at up to 7 months after the subtotal colectomy for IBD. Thus, if possible, early RPC after subtotal colectomy should be discouraged.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Dinnewitzer
authors.forename: S D
authors.initials: SD
authors.lastname: Wexner
authors.forename: M K
authors.initials: MK
authors.lastname: Baig
authors.forename: M
authors.initials: M
authors.lastname: Oberwalder
authors.forename: T
authors.initials: T
authors.lastname: Pishori
authors.forename: E G
authors.initials: EG
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: Efron
authors.forename: J J
authors.initials: JJ
authors.lastname: Nogueras
authors.forename: A M
authors.initials: AM
authors.lastname: Vernava
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D008297:Male; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome