[The relationship between ECM1 and the angiogenesis and metastasis of laryngeal carcinoma].
OBJECTIVE
To investigate the expressions of extracellular matrix protein-1 (ECM1) in laryngeal carcinoma and their relationships with the growth, metastasis and angiogenesis of tumor.


METHODS
The immunohistochemical technique was used to detect the expressions of ECM1 and VIII factor in 33 cases of laryngeal tumors. RT-PCR technology was used to test the existence of ECM1 mRNA in both fresh laryngeal tissue and its surrounding tissue (total 5 cases).


RESULTS
ECM1 is expressed in both benign and malignant laryngeal tissues, chiefly in the cellular plasma. But the expression of ECM1 (P<0.01) is significant different between benign and malignant laryngeal tumors. Their expressions are stronger in malignant tissues than in benign ones. In malignant laryngeal tissue, the expression of ECM1 is associated significantly with microvessel density (MVD) (24. 50 +/- 5.96) (Spearman's rho is 0. 505, P <0.05). ECM1 mRNA is found in both laryngeal carcinoma tissue and its surrounding tissue and it seemed no difference.


CONCLUSIONS
ECM1 played an important role in the growth, metastasis and angiogenesis of laryngeal carcinoma. The further investigation of ECM1 will benefit the treatment of laryngeal carcinoma and the judgement of its prognosis.
Han
Zhao
Z
Department of Otorhinolaryngology, Fujian Medical University Affiliated Union Hospital, Fuzhou, China.
Lin
Guojing
G
Huang
Jianmin
J
Chi
Fanglu
F
Zhang
Lurong
L
D000328:Adult; D000368:Aged; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011379:Prognosis
C490607:ECM1 protein, human; D016326:Extracellular Matrix Proteins