title: Accidental transplantation of a kidney with a cystic renal cell carcinoma following living donation: management and 1 yr follow-up.
abstract: Transmission of cancer is a fatal risk in organ transplantation. We present a case of incidental renal carcinoma in a kidney obtained from a living donor. A 56-yr-old father was evaluated for donation for his 28-yr-old daughter. An MRT scan revealed two cysts in the right kidney. Right-sided donor nephrectomy and subsequent transplantation was performed. The wall of the prominent cyst was partially excised prior to transplantation. Histology revealed a high-grade renal clear cell carcinoma 10 d after transplantation. Following careful evaluation the recipient underwent partial nephrectomy. Immunosuppression was switched to rapamune. The graft function remained stable. Donor and recipient are without evidence of tumor recurrence 1 yr after transplantation. Our policy to obtain the kidney presenting anatomical variations proved to be beneficial for the donor. In case of transmission of cancer partial resection preserving graft function might be justified.
authors.affiliation: Klinik für Allgemein, Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany. Neipp.Michael@MH-Hannover.de
authors.forename: Michael
authors.initials: M
authors.lastname: Neipp
authors.forename: Anke
authors.initials: A
authors.lastname: Schwarz
authors.forename: Stefanie
authors.initials: S
authors.lastname: Pertschy
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klempnauer
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell; D005260:Female; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007680:Kidney Neoplasms; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D019300:Medical Errors; D008875:Middle Aged; D009392:Nephrectomy; D010530:Peritoneal Dialysis; D016896:Treatment Outcome