title: [Cachexia in chronic pulmonary obstructive disease].
abstract: Weight loss is a characteristic feature of chronic obstructive pulmonary disease (COPD) and a negative, independent predictor of outcome. It is a consequence of a misbalance between protein synthesis and breakdown resulting from increased energy requirement unbalanced by dietary intake. A depletion of fat-free mass is seen, especially in muscles (up to 60% of their mass) and leads to the loss of their power and endurance. The impairment of quality of life is very distinct. So far, there is no systemic treatment in cachectic patients with COPD, anti-catabolic treatment by polyunsaturated fatty acid may be of significance but needs further investigation.
authors.affiliation: Katedry i Oddziału Klinicznego Chorób Wewnetrznych i Dermatologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Chwist-Nowak
authors.forename: Piotr
authors.initials: P
authors.lastname: Rozentryt
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chwist
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jarzab
mesh_terms: D002100:Cachexia / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D004032:Diet; D002149:Energy Intake; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology*