Macrolide-resistant Streptococcus pyogenes in Norway: population structure and resistance determinants.
A 2.7% prevalence of macrolide resistance in 1,657 Norwegian clinical Streptococcus pyogenes isolates was primarily due to erm(TR) (59%) and mef(A) (20%). Four clonal complexes comprised 75% of the strains. Macrolide resistance in S. pyogenes in Norway is imported as resistant strains or locally selected in internationally disseminated susceptible clones.
Littauer
P
P
Department of Microbiology and Infection Control, University Hospital of North Norway and Department of Microbiology and Virology, Faculty of Medicine, Institute for Medical Biology, University of Tromsø, N-9037 Tromsø, Norway. Pia.Littauer@unn.no
Caugant
D A
DA
Sangvik
M
M
Høiby
E A
EA
Sundsfjord
A
A
Simonsen
G S
GS
D000483:Alleles; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D018942:Macrolides / Q000627:therapeutic use*; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D018942:Macrolides