Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort.
Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self-reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer.
Abnet
Christian C
CC
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. abnetc@mail.nih.gov
Fan
Jin-Hu
JH
Kamangar
Farin
F
Sun
Xiu-Di
XD
Taylor
Philip R
PR
Ren
Jian-Song
JS
Mark
Steven D
SD
Zhao
Ping
P
Fraumeni
Joseph F
JF
Qiao
You-Lin
YL
Dawsey
Sanford M
SM
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology; D002299:Cardia; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006042:Goiter / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology