title: Pressure-induced gastric accommodation studied with a new distension paradigm. Abnormally low accommodation rate in patients with functional dyspepsia.
abstract: OBJECTIVE
  A new distension paradigm, by which the gastric volume response to ramp-tonic distension can be analysed in detail, has been developed. The aim of this study was to investigate the applicability of this new paradigm in man, and to compare pressure-induced gastric accommodation in healthy volunteers (HV) and patients with functional dyspepsia (FD).
  
  
  METHODS
  Ten HV, and 11 FD patients were examined twice; once in the fasting state and once postprandially. Intragastric bag pressure was raised from 1 to 12 mmHg in 4 min (ramp phase) and then kept constant for 5 min (tonic phase).
  
  
  RESULTS
  Compared to HV, fasting FD patients had lower gastric accommodation rates (0.9+/-0.2 versus 2.5+/-0.4 ml/s, p=0.002), lower maximum volume (239+/-39 versus 428+/-64 ml, p=0.01) and a longer accommodation time (157+/-26 versus 92+/-15 s, p=0.03). A test meal prior to distension tended to normalize the response in FD patients.
  
  
  CONCLUSIONS
  This new barostat paradigm allowed detailed analysis of short-term pressure-induced accommodation in man. Impaired gastric distension-induced accommodation is a novel abnormality in FD.
authors.affiliation: Section for Gastroenterology, Haukeland University Hospital, Institute of Medicine and National Centre of Ultrasound in Gastroenterology, Bergen, Norway. johan.lunding@med.uib.no
authors.forename: Johan A
authors.initials: JA
authors.lastname: Lunding
authors.forename: Solomon
authors.initials: S
authors.lastname: Tefera
authors.forename: Alfred
authors.initials: A
authors.lastname: Bayati
authors.forename: Odd Helge
authors.initials: OH
authors.lastname: Gilja
authors.forename: Hillevi
authors.initials: H
authors.lastname: Mattsson
authors.forename: Trygve
authors.initials: T
authors.lastname: Hausken
authors.forename: Arnold
authors.initials: A
authors.lastname: Berstad
mesh_terms: D016477:Artifacts; D004415:Dyspepsia / Q000503:physiopathology*; D005215:Fasting; D005773:Gastroscopy; D006801:Humans; D019518:Postprandial Period; D011312:Pressure; D012016:Reference Values; D013270:Stomach / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology