title: Evaluation of super paramagnetic iron oxide-enhanced diffusion-weighted PROPELLER T2-fast spin echo magnetic resonance imaging: Preliminary experience.
abstract: OBJECTIVE
  To evaluate the usefulness of super paramagnetic iron oxide-enhanced, diffusion-weighted, periodically rotated overlapping parallel lines with enhanced reconstruction (SPIO DWI PROPELLER) T2-fast spin echo (FSE) magnetic resonance imaging (MRI) for the detection of hepatic metastases.
  
  
  METHODS
  Fourteen patients were examined with SPIO-enhanced T2-FSE (SPIO FSE) imaging and SPIO DWI PROPELLER T2-FSE imaging. The b-value of the diffusion-sensitizing gradient was 10 s/mm so as to suppress the signal of the hepatic vessels. Hepatic resections were performed on all patients, and the number of lesions on MRI was compared between the 2 pulse sequences with references from pathologic reports.
  
  
  RESULTS
  Nearly all metastases 1 cm or larger, totalling 38 metastases, were detected with both pulse sequences. Among the 30 metastases less than 1 cm, more lesions were detected on SPIO DWI PROPELLER T2-FSE imaging than on SPIO FSE imaging (16 for SPIO FSE imaging and 24 for DWI PROPELLER T2-FSE imaging; P < 0.05, McNemar test).
  
  
  CONCLUSIONS
  Super paramagnetic iron oxide-enhanced DWI PROPELLER T2-FSE is useful for detecting small hepatic metastases.
authors.affiliation: Department of Radiology, Graduate School and Faculty of Medicine, University of Tokyo, Tokyo, Japan. kiryu-tky@umin.ac.jp
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kiryu
authors.forename: Makoto
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kabasawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akahane
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology; D003287:Contrast Media; D003911:Dextrans; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D052203:Ferrosoferric Oxide; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology; D006801:Humans; D007501:Iron; D008113:Liver Neoplasms / Q000556:secondary*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide