title: Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil.
abstract: Antihyperlipidaemic and antioxidant effect of Ocimum sanctum Linn. seed oil (OSSO) was investigated in rabbits. Administration of OSSO (0.8 g/kg body weight/day) for four weeks, in cholesterol (100 mg/kg body weight/day) fed rabbits significantly decreased serum cholesterol, triacylglycerol and LDL-+VLDL-cholesterol as compared to untreated cholesterol fed group. There was significant fall in atherogenic index in OSSO treated group. In addition, treatment with OSSO decreased lipid peroxidation and increased reduced glutathione content in blood. Antidiabetic effect of O. sanctum seed oil was evaluated in alloxan diabetic rabbits. Two weeks treatment of diabetic rabbits with OSSO (0.8 gm/kg/day) showed no significant hypoglycaemic effect. Results of the present study show that OSSO has hypocholesterolaemic and antioxidant effects but it does not have antidiabetic effect.
authors.affiliation: Department of Biochemistry, University College of Medical Science and GTB Hospital, Shahdara, Delhi, India.
authors.forename: Shweta
authors.initials: S
authors.lastname: Gupta
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Mediratta
authors.forename: Surender
authors.initials: S
authors.lastname: Singh
authors.forename: K K
authors.initials: KK
authors.lastname: Sharma
authors.forename: Rimi
authors.initials: R
authors.lastname: Shukla
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000178:diet therapy* / Q000378:metabolism; D005951:Glucose Tolerance Test; D005978:Glutathione / Q000097:blood; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008297:Male; D031339:Ocimum / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D010938:Plant Oils / Q000627:therapeutic use*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; C080118:ocimum oil; D005978:Glutathione