[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy].
OBJECTIVE
To investigate the role of immune response induced by different T-helper 1 and T-helper 2 (Th1 and Th2) ratio in peripheral blood and decidua from patients with hypertensive disorder complicating pregnancy in the pathogenesis of the disease.


METHODS
Peripheral blood and decidua from 12 non-pregnant women (no deciduas) (normal women group), 12 healthy pregnant women (healthy pregnant women group), 10 patients with gestational hypertension (gestational hypertension group), 25 patients with pre-eclampsia (PE) (including 10 patients with mild pre-eclampsia and 15 patients with severe pre-eclampsia) (pre-eclampsia group). Th1/Th2 ratio in peripheral blood and decidua was determined by flow-cytometrically.


RESULTS
The ratio of Th1/Th2 in peripheral blood with normal women group is 10.5 +/- 1.5, the ratios of Th1/Th2 in peripheral blood and deciduas with healthy pregnant women group are 9.5 +/- 2.9 and 7.6 +/- 4.6 respectively, those with gestational hypertension group are 12.1 +/- 3.4 and 13.1 +/- 5.6 respectively, those with pre-eclampsia group are 16.8 +/- 3.8 and 26.7 +/- 9.4 respectively. The ratios of Th1/Th2 in peripheral blood and deciduas with pre-eclampsia group are much higher than those with other groups, when they are compared with each other, there are statistical difference (P < 0.05). And the ratio of Th1/Th2 with pre-eclampsia in deciduas is much higher than that in peripheral blood, comparing these two aspects, there is statistical difference (P < 0.001). The changes of Th1/Th2 ratio in gestational hypertension group is an intermediate between healthy pregnant group and pre-eclampsia group.


CONCLUSIONS
Hypertensive disorder complicating pregnancy is a syndrome of Th1/Th2 cell balance disturbances in vivo. Over-expression of Th1 cells and imbalance of Th1/Th2 might lead to hypertensive disorder complicating pregnancy.
Lü
Ying-pu
YP
Department of Obstetrics and Gynecology, Second Hospital, Hebei Medical University, Shijiazhuang 050000, China.
Zhang
Wen-zhen
WZ
Lu
Shi-yan
SY
Xin
Hong
H
D000328:Adult; D001724:Birth Weight; D003656:Decidua / Q000276:immunology* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000276:immunology*; D007231:Infant, Newborn; D018655:Lymphocyte Count; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*