Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones.
OBJECTIVE
To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton.


METHODS
The histology and immunohistochemistry of 4 PSOFs, 6 COFs, and 7 PMs was studied. Antibodies included EMA, cytokeratins, smooth muscle actin (SMA), desmin, vimentin, CD34, CD10, S-100 protein, and glial fibrillary acidic protein (GFAP).


RESULTS
All PSOFs showed multiple round ossicles homogeneously distributed within a fibroblastic stroma. Psammomatous meningiomas had meningothelial features. All tumors, except 1 COF, were positive for EMA. All of them expressed vimentin, and none showed cytokeratins. Staining for SMA and S-100 protein was variable. CD10 was positive in all cases except 2 meningiomas. CD34 and GFAP stained only 1 case of meningioma each.


CONCLUSIONS
The diagnosis of PSOF should rest on histologic features. An incorrect diagnosis of meningioma based on the expression of EMA should be avoided.
Granados
Rosario
R
University Hospital of Getafe, Madrid, Spain. rgranado@teleline.es
Carrillo
Rosario
R
Nájera
Laura
L
García-Villanueva
Mercedes
M
Patrón
Mercedes
M
D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D002485:Cementoma / Q000737:chemistry / Q000175:diagnosis; D002648:Child; D003937:Diagnosis, Differential; D005005:Ethmoid Sinus / Q000473:pathology*; D005260:Female; D018214:Fibroma, Ossifying / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000737:chemistry / Q000175:diagnosis; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000175:diagnosis; D008579:Meningioma / Q000737:chemistry / Q000175:diagnosis; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000473:pathology*; D013101:Sphenoid Sinus / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D000199:Actins; D018952:Antigens, CD34; D018396:Mucin-1; D014746:Vimentin