title: Lignans from Arnica species.
abstract: From four Arnica species (A. angustifolia Vahl ssp. attenuata (Greene) Maguire, A. lonchophylla Greene ssp. lonchophylla Maguire (flowerheads), A. chamissonis Less. ssp. foliosa (Nutt.) Maguire, A. montana L. (roots and rhizomes)) a total of twelve lignans of the furofuran-, dibenzylbutyrolactone- and dibenzylbutyrolactol-type were isolated. No report on lignans as constituents of Arnica species exists so far. Besides the known pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin and nortracheloside, six dibenzylbutyrolactol derivatives with different stereochemistry and substitution at C-9 were isolated and their structures elucidated by NMR spectroscopic and mass spectral analysis.
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie der Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany. thomschm@uni-meunster.de
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Schmidt
authors.forename: Sabine
authors.initials: S
authors.lastname: Stausberg
authors.forename: Jeanette Von
authors.initials: JV
authors.lastname: Raison
authors.forename: Matthias
authors.initials: M
authors.lastname: Berner
authors.forename: Günter
authors.initials: G
authors.lastname: Willuhn
mesh_terms: D018650:Arnica; D006801:Humans; D017705:Lignans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots; D027343:Rhizome
chemical_list: D017705:Lignans; D010936:Plant Extracts