title: Pediatric stroke associated with new onset type 1 diabetes mellitus: case reports and review of the literature.
abstract: Neurological deterioration in children with diabetic ketoacidosis (DKA) is commonly caused by cerebral edema. However, stroke should also be suspected when focal neurological deficits are apparent, because children with hyperglycemia and DKA are prone to thrombosis. We report three cases of pediatric stroke associated with new onset type 1 diabetes mellitus (T1DM). The first case presented with sinovenous thrombosis, and the other two cases presented in DKA and had a late diagnosis of ischemic stroke following neurological deterioration. Our recent experiences and review of the literature emphasize the importance of early diagnosis, investigation, and treatment for patients that present with new onset T1DM and stroke.
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Josephine
authors.initials: J
authors.lastname: Ho
authors.forename: Jean K
authors.initials: JK
authors.lastname: Mah
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
authors.forename: Danièle
authors.initials: D
authors.lastname: Pacaud
mesh_terms: D000293:Adolescent; D000749:Anemia, Megaloblastic / Q000175:diagnosis; D002539:Cerebral Arterial Diseases / Q000175:diagnosis / Q000601:surgery; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome