title: Common and distinct neural correlates of obsessive-compulsive and related disorders.
abstract: Obsessive-compulsive disorder (OCD) often co-occurs with other anxiety disorders and a number of other disorders of similar phenomenology known as the "OCD spectrum" disorders. Neurobiologically, it is unclear how all these disorders relate to each other. The picture is further complicated by the clinical heterogeneity of OCD itself. This article reviews the literature on the common and distinct neural correlates of OCD, its symptom dimensions, and other anxiety and OCD spectrum disorders with the hope of providing a conceptual and heuristic framework to help understand the relationship between these phenomena.
authors.affiliation: Department of Psychological Medicine, King's College London, Institute of Psychiatry, London SE5 8AF, UK. d.mataix@iop.kcl.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Mataix-Cols
authors.forename: Odile A
authors.initials: OA
authors.lastname: van den Heuvel
mesh_terms: D001008:Anxiety Disorders / Q000453:epidemiology* / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008032:Limbic System / Q000378:metabolism / Q000503:physiopathology; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D013788:Thalamus / Q000378:metabolism / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid