title: Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study.
abstract: Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with Alzheimer's disease plaques. The authors examined a G-463A polymorphism in the promoter region of the myeloperoxidase gene (MPO) to determine the relation of MPO variants to cognitive decline over 4 years in a cohort of adults, aged 70-79 years at baseline (1997-1998), recruited from Memphis, Tennessee, and Pittsburgh, Pennsylvania, into the Health, Aging, and Body Composition Study. In this sample, 8% of the participants had the AA, 36.9% the AG, and 55.2% the GG genotype of MPO. The frequency of AA and AG genotypes was higher in Blacks than Whites (11.2% vs. 5.9%, and 44.1% vs. 32.9%, respectively). Multivariate logistic regression analyses showed that, for participants with the MPO AA genotype, cognitive decline was 1.58 (95% confidence interval: 1.07, 2.35) times more likely than for participants with the AG genotype and 1.96 (95% confidence interval: 1.33, 2.88) times more likely than for those with the GG genotype. Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for cognitive decline.
authors.affiliation: Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. skpope@uams.edu
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Pope
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.forename: Christine
authors.initials: C
authors.lastname: Ambrosone
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Frances
authors.initials: F
authors.lastname: Tylavsky
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Simonsick
authors.forename: Caterina
authors.initials: C
authors.lastname: Rosano
authors.forename: Scott
authors.initials: S
authors.lastname: Stewart
authors.forename: Tamara
authors.initials: T
authors.lastname: Harris
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D044383:Black People / Q000706:statistics & numerical data; D001823:Body Composition; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D044465:White People / Q000706:statistics & numerical data
chemical_list: D009195:Peroxidase