title: Miliary tuberculomas of the brain: case report.
abstract: Tuberculosis (TB) of the central nervous system (CNS) is still prevalent in many developing countries. Tuberculoma is always considered in the differential diagnosis of enhancing intra-axial lesions of the brain. Brain tuberculomas can present in many different clinical and radiological patterns, disseminated or miliary brain tuberculomas are very rare. We describe the case of a 25-year-old immunocompetent female with miliary brain tuberculomas. She presented with a history of progressive headache and unsteady gait. Serial Magnetic resonance imaging (MRI) studies revealed growing, multiple small enhancing lesions in the brain, most lesions measured approximately 2mm in diameter, in both the supratentorial and infratentorial compartments. Her investigation failed to reveal any evidence of TB outside the CNS. Open biopsy revealed multiple caseating granulomas and mycobacterin tuberculosis was cultured. She improved clinically and radiologically after starting anti-tuberculous pharmacotherapy. The clinical course, radiological images and pathological studies of this patient are presented. In conclusion miliary brain tuberculomas are rare and unique clinical and radiological entity. It may affect immunocompetent individuals with no other signs of other systemic involvement.
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, MBC-76, P.O. Box 3354, Riyadh 11211, Saudi Arabia. alkhani@kfshrc.edu.sa
authors.forename: Ahmed
authors.initials: A
authors.lastname: Alkhani
authors.forename: Faisal
authors.initials: F
authors.lastname: Al-Otaibi
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Cupler
authors.forename: Boleslaw
authors.initials: B
authors.lastname: Lach
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009069:Movement Disorders / Q000209:etiology; D010211:Papilledema / Q000150:complications; D014391:Tuberculosis, Miliary / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents