Long-term mortality after intracerebral hemorrhage.
OBJECTIVE
To characterize long-term mortality following intracerebral hemorrhage (ICH) in two large population-based cohorts assembled more than a decade apart.


METHODS
All patients age > or = 18 hospitalized with nontraumatic ICH in the Greater Cincinnati/Northern Kentucky area were identified during 1988 (Cohort 1) and from May 1998 to July 2001 and August 2002 to April 2003 (Cohort 2). Mortality was tabulated using actuarial methods and compared with a log-rank test.


RESULTS
There were 183 patients with ICH in Cohort 1 and 1,041 patients in Cohort 2. Patients in Cohort 1 were more likely to be white (p = 0.024) and undergo operation for their ICH (p = 0.002), whereas patients in Cohort 2 were more commonly on anticoagulants (p < 0.001). Among patients in Cohort 1, mortality at 7 days, 1 year, and 10 years was 31, 59, and 82%. Among patients in Cohort 2, mortality at 7 days and 1 year was 34 and 53%. Mortality rates did not differ between cohorts by log-rank test (p = 0.259).


CONCLUSIONS
Intracerebral hemorrhage (ICH) mortality did not improve significantly between study periods. Operation for ICH became less frequent, whereas anticoagulant-associated ICH became more common.
Flaherty
M L
ML
Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267-0525, USA. matthew.flaherty@uc.edu
Haverbusch
M
M
Sekar
P
P
Kissela
B
B
Kleindorfer
D
D
Moomaw
C J
CJ
Sauerbeck
L
L
Schneider
A
A
Broderick
J P
JP
Woo
D
D
D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007629:Kentucky; D008297:Male; D009820:Ohio; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors