title: Recurrent intracardiac thrombosis as an unusual manifestation of inherited thrombophilia.
abstract: Patients with inherited thrombophilia are at high risk for the development of venous thrombosis that manifests mainly as deep venous thrombosis of the legs and/or pulmonary embolism. We report spontaneous right-sided intracardiac thrombosis in a young man as an unusual manifestation of inherited thrombophilia. The diagnosis of thrombophilia was confirmed by demonstration of the prothrombin-G20210A-mutation in the homozygous state. A second spontaneous intracardiac thrombosis occurred 3 years after discontinuation of oral anticoagulant treatment. This indicates the high risk for recurrence in patients developing intracardiac thrombosis in the absence of an underlying cardiac disease and warrants long-term oral anticoagulant treatment.
authors.forename: Sandra
authors.initials: S
authors.lastname: Ohlenforst
authors.forename: Jens
authors.initials: J
authors.lastname: Mueller
authors.forename: Jutta M
authors.initials: JM
authors.lastname: Rox
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Bernd
authors.initials: B
authors.lastname: Pötzsch
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003328:Coronary Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
chemical_list: D000925:Anticoagulants