title: Efficacy and safety of topical selamectin to eradicate pinworm (Syphacia spp.) infections in rats (Rattus norvegicus) and mice (Mus musculus).
abstract: We evaluated the efficacy and safety of topical selamectin, a novel avermectin, in eliminating naturally acquired Syphacia muris infections in rats and S. obvelata infections in mice. S. muris-positive rats were assigned randomly to 4 groups: selamectin (0.6 mg/kg), selamectin (6.0 mg/kg), fenbendazole-medicated (150 ppm) chow, and untreated. S. obvelata-positive mice were allocated into 4 groups similar to those for rats. Animals not exposed to pinworm-contaminated bedding were designated as negative controls. Treatment success was assessed weekly by anal tape impressions and by necropsy examinations at the end of week 9. Evaluations of intestinal contents at necropsy revealed that, although safe, topical selamectin was 100% ineffective in eliminating Syphacia spp. infections in rats and mice. Treatment with fenbendazole-medicated chow resulted in negative anal tape impressions beginning at week 2 in rats and week 1 in mice. Negative anal tape impressions in fenbendazole-treated animals were confirmed by negative intestinal content evaluations. Of the 2 treatments evaluated, fenbendazole-medicated chow remains an effective and practical method to eliminate pinworm infections in mice and rats.
authors.affiliation: Department of Comparative Medicine, College of Medicine, The University of Tennessee Health Science Center, and St Jude Children's Research Hospital, Animal Resources Center, Memphis, USA. whill2@utmem.edu
authors.forename: William Allen
authors.initials: WA
authors.lastname: Hill
authors.forename: Mildred Montgomery
authors.initials: MM
authors.lastname: Randolph
authors.forename: Sharon Jean
authors.initials: SJ
authors.lastname: Lokey
authors.forename: Ernestine
authors.initials: E
authors.lastname: Hayes
authors.forename: Kelli Lynn
authors.initials: KL
authors.lastname: Boyd
authors.forename: Timothy David
authors.initials: TD
authors.lastname: Mandrell
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary*; D010124:Oxyuroidea / Q000187:drug effects*; D051381:Rats; D012376:Rodent Diseases / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin