Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).
Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.
Choi
Sung-Kyu
SK
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
Oh
Hyun-Mi
HM
Lee
Su-Kyung
SK
Jeong
Dae Gwin
DG
Ryu
Seong Eon
SE
Son
Kwang-Hee
KH
Han
Dong Cho
DC
Sung
Nack-Do
ND
Baek
Nam-In
NI
Kwon
Byoung-Mog
BM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020946:Taxus / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D001688:Biological Products; D005419:Flavonoids; D009363:Neoplasm Proteins; C077458:ginkgetin; C086243:sciadopitysin; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases