title: Placement of a metallic stent across the main duodenal papilla may predispose to cholangitis.
abstract: BACKGROUND
  Cholangitis is a major complication after metallic stent placement to treat biliary obstruction, and it may impair quality of life. Whether transpapillary stent placement contributes cholangitis is still controversial.
  
  
  OBJECTIVE
  The present study aimed to determine risk factors for acute cholangitis after metallic biliary stent placement.
  
  
  METHODS
  Retrospective cases series.
  
  
  METHODS
  A total of 108 patients with malignant biliary obstruction were treated with metallic stents, resulting in 12 cases of cholangitis.
  
  
  METHODS
  A multiple logistic regression model was performed with clinical parameters, including stent placement across the main duodenal papilla.
  
  
  RESULTS
  By multiple logistic regression model, age; lower location; and Wallstent, Ultraflex stent, and covered stent were negatively associated with cholangitis. Restenosis and placement across the main duodenal papilla were positively associated with the occurrence of cholangitis. Transpapillary stent placement was the most significant risk factor. In this logistic model, the area under a receiver operating characteristics curve was computed as 0.92: sensitivity, 0.92 (95% confidential interval (CI), 0.62-1.00); specificity, 0.86 (95% CI, 0.78-0.93); positive predictive value, 0.46 (95% CI, 0.26-0.67); and negative predictive value, 0.99 (95% CI, 0.94-1.00).
  
  
  CONCLUSIONS
  Disruption of the sphincter mechanism by transpapillary placement may be the most important etiologic factor in the propensity for cholangitis after metallic stent placement for malignant biliary obstruction.
authors.affiliation: Department of Surgery, School of Medicine, The Jikei University, Tokyo, Japan.
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Fujioka
authors.forename: Satoru
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakutani
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Urashima
mesh_terms: D000208:Acute Disease; D000368:Aged; D014670:Ampulla of Vater; D002761:Cholangitis / Q000453:epidemiology / Q000209:etiology*; D002779:Cholestasis / Q000209:etiology / Q000628:therapy*; D003251:Constriction, Pathologic; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications; D006801:Humans; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications; D012372:ROC Curve; D012008:Recurrence; D015607:Stents
chemical_list: D008670:Metals