Worsening of obsessive-compulsive symptoms under methadone tapering.
There is data supporting the hypothesis that the endogenous opioid system may play a role in the pathophysiology of Obsessive Compulsive Disorder (OCD). The authors report a case of worsening of OCD during methadone tapering, which seems to confirm the role of the opioid system in the pathophysiology of OCD. The possible involvement of the cortico-limbic-basal-ganglia-thalamic circuit in the observed phenomenon is discussed.
Khazaal
Yasser
Y
Département Universitaire de Psychiatrie Adulte, Prilly - Lausanne, Switzerland. yasser.khazaal@chuv.ch <yasser.khazaal@chuv.ch>
Krenz
Sonia
S
Benmebarek
Messaoud
M
Zullino
Daniele Fabio
DF
D000328:Adult; D000075202:Contraindications; D006801:Humans; D008297:Male; D008691:Methadone; D009294:Narcotics; D009771:Obsessive-Compulsive Disorder / Q000534:rehabilitation*
D009294:Narcotics; D008691:Methadone