An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population.
We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.
Yazdanpanah
Mojgan
M
Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands.
Rietveld
Ingrid
I
Janssen
Joop A M J L
JA
Njajou
Omer T
OT
Hofman
Albert
A
Stijnen
Theo
T
Pols
Huibert A P
HA
Lamberts
Steven W J
SW
Witteman
Jacqueline C M
JC
van Duijn
Cornelia M
CM
D000368:Aged; D005500:Follow-Up Studies; D006579:Heterozygote; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality*; D009426:Netherlands / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016016:Proportional Hazards Models; D044465:White People / Q000235:genetics
D007334:Insulin-Like Growth Factor I