title: Infective endocarditis in a Finnish teaching hospital: a study on 326 episodes treated during 1980-2004.
abstract: OBJECTIVE
  To evaluate potential changes of infective endocarditis (IE) in patients treated in a Finnish teaching hospital during the past 25 years.
  
  
  METHODS
  326 episodes of IE in 303 patients treated during 1980-2004 were evaluated for clinical characteristics and their changes over time.
  
  
  RESULTS
  The mean age of the patients increased with time (from 47.2 to 54.5 years, p = 0.003). Twenty-five (7.7%) episodes were associated with intravenous drug use (IVDU), with a significant increase of these episodes after 1996 (from 0 to 19 (20%), p < 0.001). Viridans streptococci were the most common causative agents of IE during 1980-1994, but after that Staphylococcus aureus was the most common pathogen (p = 0.015). The proportion of IE of the aortic valve decreased during the study (from 30 (49%) to 26 (27%), whereas the proportions of mitral (11 (18%) to 33 (35%) and tricuspid valve IE (0 to 13 (14%) increased correspondingly (p = 0.001). This was mainly due to more patients with IVDU. Chronic dialysis for renal failure as an underlying condition increased over time (from 0 to 7 (7.4%), p = 0.015) but no other predisposing conditions changed. Complications such as neurological manifestations and heart failure did not change in frequency, but the incidence of lung emboli increased (from 0% to 10.5%, p < 0.001); 83% of these emboli occurred in patients with IVDU. The proportion of patients requiring surgical treatment and mortality due to IE did not change.
  
  
  CONCLUSIONS
  During these 25 years, the causative agents, affected valves and complications of IE changed to some degree. These changes were mainly attributed to the increase of IVDU-associated IE. Except for the increase in age, the clinical presentation and outcome in non-addicts remained substantially unchanged.
authors.affiliation: Department of Medicine, Turku University Hospital, Finland. maija.heiro@tyks.fi
authors.forename: M
authors.initials: M
authors.lastname: Heiro
authors.forename: H
authors.initials: H
authors.lastname: Helenius
authors.forename: S
authors.initials: S
authors.lastname: Mäkilä
authors.forename: U
authors.initials: U
authors.lastname: Hohenthal
authors.forename: T
authors.initials: T
authors.lastname: Savunen
authors.forename: E
authors.initials: E
authors.lastname: Engblom
authors.forename: J
authors.initials: J
authors.lastname: Nikoskelainen
authors.forename: P
authors.initials: P
authors.lastname: Kotilainen
mesh_terms: D000328:Adult; D004697:Endocarditis, Bacterial / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D005387:Finland; D006349:Heart Valve Diseases / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data* / Q000639:trends; D006784:Hospitals, Teaching; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D006435:Renal Dialysis; D017678:Sex Distribution; D015819:Substance Abuse, Intravenous / Q000453:epidemiology