A tale of three genomes: the kinetoplastids have arrived.
July 2005 marked a milestone in kinetoplastid biology research. A tour de force effort led by the Tri-Trypanosomatidae "Tritryp" genome consortium yielded the publication of three prominent kinetoplastid parasite genome sequences: Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. The individual and combined comparative analyses of these three genome sequences, combined with proteomic analyses, have yielded insights into topics ranging from genome evolution and horizontal gene transfer to potential new therapeutic and vaccine targets.
Kissinger
Jessica C
JC
Department of Genetics and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30606, USA. jkissing@uga.edu
D000818:Animals; D018014:Gene Transfer Techniques; D008040:Genetic Linkage; D018503:Genome, Protozoan; D018320:Leishmania major / Q000235:genetics*; D016052:Protozoan Vaccines; D014346:Trypanosoma brucei brucei / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
D016052:Protozoan Vaccines