title: Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer.
abstract: The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the initiation and progression of breast cancer. Previous studies have indicated that acquisition of the malignant phenotype in breast cancer is initially IGF-IR dependent. Most breast cancer-derived cell lines and primary tumors express high levels of IGF-IR mRNA and protein, whereas metastatic stages are usually associated with a decrease in IGF-IR levels. Transcription of the IGF-IR gene is controlled by complex interactions involving DNA-binding and non DNA-binding transcription factors. This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression.
authors.affiliation: Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Rive
authors.initials: R
authors.lastname: Sarfstein
authors.forename: Sharon
authors.initials: S
authors.lastname: Maor
authors.forename: Naama
authors.initials: N
authors.lastname: Reizner
authors.forename: Shirley
authors.initials: S
authors.lastname: Abramovitch
authors.forename: Haim
authors.initials: H
authors.lastname: Werner
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019398:Genes, BRCA1; D016158:Genes, p53; D006801:Humans; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors; D017526:Receptor, IGF Type 1