A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.
Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.
Yuan
Fang
F
Department of Pathology, and Microbiology & Immunology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
Verhelst
Steven H L
SH
Blum
Galia
G
Coussens
Lisa M
LM
Bogyo
Matthew
M
D000818:Animals; D020789:Cathepsin C / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D015335:Molecular Probes
D015335:Molecular Probes; D020789:Cathepsin C