A further study of a possible locus for schizophrenia on the X chromosome.
Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi2=6.85, P=0.009) and rs5905724 (chi2=5.3, P=0.021) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi2=12.19, df=4, P=0.016) but did not show such an association for the rs5943414-rs1324805 haplotypes (chi2=3.96, df=2, P=0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.
Wei
Jun
J
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bangor, Gwynedd LL57 2AG, UK. jwei@litbio.org
Hemmings
Gwynneth P
GP
D020746:Calcium Channels, L-Type / Q000235:genetics*; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X / Q000235:genetics*; D003066:Coenzyme A Ligases / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D000098859:Long-Chain-Fatty-Acid-CoA Ligase
C113330:CACNA1F protein, human; D020746:Calcium Channels, L-Type; D003066:Coenzyme A Ligases; D000098859:Long-Chain-Fatty-Acid-CoA Ligase