A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arrestin2/G-protein coupling antagonists.
Bruns
I R
IR
Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Chhum
S
S
Dinh
A T
AT
Doerr
H
H
Dunn
N R
NR
Ly
Y T
YT
Mitman
C L
CL
Rickards
H D
HD
Sol
C
C
Wan
E W
EW
Raffa
R B
RB
D000698:Analgesia; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D019390:Arrestins / Q000037:antagonists & inhibitors* / Q000145:classification / Q000502:physiology; D006801:Humans; D009020:Morphine / Q000009:adverse effects / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000145:classification / Q000502:physiology; D000071557:beta-Arrestins
D000701:Analgesics, Opioid; D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D000071557:beta-Arrestins; D009020:Morphine