Sestamibi single photon emission computed tomography immediately after primary percutaneous coronary intervention identifies patients at risk for large infarcts.
BACKGROUND
Primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction results in TIMI 3 flow in most patients. However, despite TIMI 3 flow, some patients do not achieve adequate tissue perfusion and have large infarctions. Techniques that, in the acute setting, could identify these patients at increased risk would potentially enable specific interventions to enhance perfusion. The object of the present study was to test whether corrected TIMI frame count (CTFC), myocardial blush grade (MBG), ST-segment resolution, and myocardial perfusion imaging (MPI) can identify those patients who, despite successful treatment with primary PCI for ST-elevation myocardial infarction, are at risk for large infarcts.


METHODS
In 61 patients with TIMI 3 flow after primary PCI, CTFC, MBG, ST-segment resolution, and quantitative MPI by technetium Tc 99m sestamibi single photon emission computed tomography were estimated immediately after primary PCI. Infarct size was assessed by peak lactate dehydrogenase (LDH) and by MPI after 3 months.


RESULTS
Infarct size by MPI was 12% (4, 23), and peak LDH was 1410 U/L (870, 2220); these measures correlated (rho = 0.80, P < .001). The acute perfusion defect predicted infarct size using either method (MPI rho = 0.88, P < .001; LDH rho = 0.77, P < .001); ST-segment residual correlated weakly to infarct size, whereas CTFC and MBG did not. In multivariate analysis, the acute perfusion defect was the only significant predictor of infarct size.


CONCLUSIONS
Myocardial perfusion imaging performed immediately after successful PCI can identify patients at increased risk for large infarcts due to impaired tissue perfusion. Acute MPI might serve as a tool for early identification of patients, who, despite epicardial TIMI 3 flow, have inadequate tissue level perfusion.
Kaltoft
Anne
A
Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
Bøttcher
Morten
M
Sand
Niels Peter
NP
Rehling
Michael
M
Andersen
Niels Trolle
NT
Zijlstra
Felix
F
Nielsen
Torsten Toftegaard
TT
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D015425:Myocardial Reperfusion; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012008:Recurrence; D012307:Risk Factors; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi