title: Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
abstract: The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).
authors.affiliation: Genomics Institute of the Novartis Research Foundation, GNF, 10675 John Jay Hopkins Dr. San Diego, CA 92121, USA. bwu@gnf.org
authors.forename: Baogen
authors.initials: B
authors.lastname: Wu
authors.forename: Kelli
authors.initials: K
authors.lastname: Kuhen
authors.forename: Truc
authors.initials: T
authors.lastname: Ngoc Nguyen
authors.forename: David
authors.initials: D
authors.lastname: Ellis
authors.forename: Beth
authors.initials: B
authors.lastname: Anaclerio
authors.forename: Xiaohui
authors.initials: X
authors.lastname: He
authors.forename: Kunyong
authors.initials: K
authors.lastname: Yang
authors.forename: Donald
authors.initials: D
authors.lastname: Karanewsky
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Karen
authors.initials: K
authors.lastname: Wolff
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bieza
authors.forename: Jeremy
authors.initials: J
authors.lastname: Caldwell
authors.forename: Yun
authors.initials: Y
authors.lastname: He
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D011760:Pyrrolidinones; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase