title: The structures of fluostatins C, D and E, novel members of the fluostatin family.
abstract: Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383. The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy. The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters. These compounds represent the first reported epoxide fluostatins (1, 2) and underline previously found analogies to the group of kinamycin antibiotics.
authors.affiliation: Institut für Organische Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, D-10623 Berlin, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Graeme
authors.initials: G
authors.lastname: Nicholson
authors.forename: Markus
authors.initials: M
authors.lastname: Ströbele
authors.forename: Stephanie
authors.initials: S
authors.lastname: Baur
authors.forename: Jörg
authors.initials: J
authors.lastname: Niehaus
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D005449:Fluorenes / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism
chemical_list: D005449:Fluorenes