title: Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor.
abstract: The molecular mechanism of how resveratrol inhibits mast cell degranulation was studied by examining its effects on the signaling components of the high affinity IgE receptor (FcepsilonRI) pathway. Resveratrol inhibited mast cell degranulation in a dose-dependent manner and reduced the FcepsilonRI-mediated tyrosine phosphorylation of ERK and PLCgamma1 but not of Syk and PLCgamma2. U-73 122 and PD98059, which are PLC and MEK inhibitors, also had inhibitory effects on mast cell degranulation. These results suggest that FcepsilonRI-mediated tyrosine phosphorylation of PLCgamma1 and ERK could be potential cellular targets of resveratrol for the inhibition of mast cell degranulation.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
authors.forename: NaYeon
authors.initials: N
authors.lastname: Koo
authors.forename: DongIm
authors.initials: D
authors.lastname: Cho
authors.forename: YoungRan
authors.initials: Y
authors.lastname: Kim
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Choi
authors.forename: Kyeong-Man
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D010766:Phosphorylation / Q000187:drug effects; D011505:Protein-Tyrosine Kinases / Q000187:drug effects*; D051381:Rats; D017455:Receptors, IgE / Q000187:drug effects*; D000077185:Resveratrol; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*; D014703:Veratrum / Q000737:chemistry
chemical_list: D017455:Receptors, IgE; D013267:Stilbenes; D011505:Protein-Tyrosine Kinases; D000077185:Resveratrol