MSTF: a domain involved in bacterial metallopeptidases and surface proteins, mycobacteriophage tape-measure proteins and fungal proteins.
Here we report a novel domain, MSTF (domain involved in bacterial metallopeptidases, surface proteins and other proteins, also present in mycobacteriophage tape-measure proteins and fungal proteins), which is present in bacteria, phages and fungi. MSTF is about 67-94 amino acids in length with one HxDHxH motif and some highly conserved residues including His, Gly, Ala and Asp. Secondary structure prediction indicated that this domain contains two alpha-helices and one beta-sheet. Identification of MSTF will provide an opportunity to develop new strategies to combat pathogenic microorganisms, especially Mycobacterium tuberculosis.
Lai
Xuhui
X
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Weng
Jifeng
J
Zhang
Xuelian
X
Shi
Wenjun
W
Zhao
Jingjing
J
Wang
Haipeng
H
Wang
Honghai
H
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry*; D005656:Fungal Proteins / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D045726:Metalloproteases / Q000737:chemistry*; D008969:Molecular Sequence Data; D009160:Mycobacteriophages / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D001426:Bacterial Proteins; D005656:Fungal Proteins; D008565:Membrane Proteins; D045726:Metalloproteases