Bioenergetics of aging and calorie restriction.
Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.
Hunt
Nicole D
ND
Laboratory of Experimental Gerontology, NIA, NIH, Gerontology Research Center, Box 10, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA.
Hyun
Dong-Hoon
DH
Allard
Joanne S
JS
Minor
Robin K
RK
Mattson
Mark P
MP
Ingram
Donald K
DK
de Cabo
Rafael
R
D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological