Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis.
OBJECTIVE
Thioredoxin 1 (TRX-1), a redox-regulating protein with antioxidant activity, is induced by oxidative stress, and serum TRX-1 levels are recognized as an oxidative-stress marker. The aim of this study was to clarify the clinical significance of serum TRX-1 levels in patients with acute pancreatitis (AP) and evaluate the usefulness of this measurement in assessing disease severity.


METHODS
Serum TRX-1 levels were determined on admission in 18 patients with severe AP and 36 patients with mild AP. We also investigated the relationship between serum TRX-1 levels and clinical and laboratory data.


RESULTS
The median serum TRX-1 levels on admission were 54.9 ng/mL in mild AP and 118.8 ng/mL in severe AP. When the cutoff value for TRX-1 in predicting severe AP was determined to be 100 ng/mL, its sensitivity, specificity, and accuracy were 83.3%, 94.4%, and 90.7%, respectively. A significant correlation was observed between serum TRX-1 levels and Ranson score (r = 0.674), C-reactive protein (r = 0.718), interleukin 6 (r = 0.712), leukocyte count (r = 0.642), and serum amylase (r = 0.436).


CONCLUSIONS
Serum TRX-1 levels significantly correlate with AP severity. TRX-1 should constitute a reliable oxidative-stress marker for the evaluation of AP severity in relation to oxidative stress.
Ohashi
Shinya
S
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nishio
Akiyoshi
A
Nakamura
Hajime
H
Kido
Masahiro
M
Kiriya
Keiichi
K
Asada
Masanori
M
Tamaki
Hiroyuki
H
Fukui
Toshiro
T
Kawasaki
Kimio
K
Watanabe
Norihiko
N
Yodoi
Junji
J
Okazaki
Kazuichi
K
Chiba
Tsutomu
T
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D013879:Thioredoxins / Q000097:blood*
D015850:Interleukin-6; D013879:Thioredoxins; D002097:C-Reactive Protein