title: Sinus graft with biogran, autogenous bone, and PRP: a report of three cases with histology and micro-CT.
abstract: Three sinuses were grafted with a bioactive glass bone substitute (Biogran) mixed with autogenous bone retrieved from intraoral donor sites. In two of the three sinuses a platelet-rich plasma (PRP) gel was added to the graft. Bone biopsies retrieved after 5, 6, and 15 months were analyzed. Micro-computerized tomography (micro-CT) values of total bone volume/total volume (TBV/TV) were very reliable compared to histomorphometry. Biogran mixed with autogenous bone and PRP seems to have a positive effect in sinus grafting, with TBV/TV values ranging between 40% and 68%. Micro-CT results have never been compared with histomorphometry for the evaluation of grafted biomaterials. Micro-CT evaluation of some morphometric parameters was difficult, because the radiodensities of Biogran and a certain grade of bone mineralization were similar.
authors.affiliation: Biomaterials Clinical Research Association, Pescara, Italy. paulbioc@tin.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Trisi
authors.forename: Alberto
authors.initials: A
authors.lastname: Rebaudi
authors.forename: Federica
authors.initials: F
authors.lastname: Calvari
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lazzara
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D001706:Biopsy; D001792:Blood Platelets; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000000981:diagnostic imaging* / Q000473:pathology; D003758:Dental Implantation, Endosseous / Q000379:methods; D005898:Glass; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010949:Plasma / Q000166:cytology; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D001672:Biocompatible Materials; C073544:Biogran; D018786:Bone Substitutes