Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue.
Primary invasive aspergillosis of the gut is a rare event and is associated with high mortality. We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation. Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination. No other site of invasive aspergillosis was evident. The patient was successfully treated with early surgery and combination antifungal therapy.
Lehrnbecher
Thomas
T
Department of Pediatric Hematology, Johann Wolfgang University of Frankfurt, Germany. thomas.lehrnbecher@kgu.de
Becker
Martina
M
Schwabe
Dirk
D
Köhl
Ulrike
U
Kriener
Susanne
S
Hunfeld
Klaus-Peter
KP
Schmidt
Helga
H
Beyer
Peter
P
Klingebiel
Thomas
T
Bader
Peter
P
Sörensen
Jan
J
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D008297:Male; D017599:Neuroectodermal Tumors / Q000188:drug therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects*
D000970:Antineoplastic Agents