Intraplacental retinol distribution.
With the objective of evaluating intraplacental vitamin A distribution, 234 placental samples were collected, corresponding to six samples from each of the placentas analyzed: two from the lateral maternal portion, one from the central maternal portion, two from the lateral fetal portion, and one from the central fetal portion. Samples were obtained from 39 adult puerperal mothers with low-risk pregnancies, without vitamin A deficiency or night blindness. Retinol content determination was achieved through spectrophotometry. Retinol values obtained for each region were correlated with the most probable value for each placenta (P < 0.001). Despite differences in retinol content between samples, statistical data analysis showed that intra-tissue variation had no influence on the conversion of data into information. Consequently, any portion of the placenta may be used for retinol level determination purposes, due to the correlation between all portions and the most probable value. The findings of the present study represent an advance for surveys intending to incorporate the collection and dosage of placental vitamin A levels into their analyses, thus increasing the arsenal of pre-pathological or subclinical vitamin A deficiency markers, which can allow for earlier intervention on the maternal-infant group.
Saunders
Cláudia
C
D.Sc. Research Group on Vitamin A (Grupo de Pesquisa em Vitamina A), Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Brazil.
Leal
Maria Do Carmo
Mdo C
Flores
Hernando
H
Soares
Alexandre Gonçalves
AG
De Lima
Ana Paula Pereira Thiapó
AP
Leite
Paula Costa
PC
Gomes
Mirian Martins
MM
De Souza Júnior
Paulo Roberto Borges
PR
Ramalho
Rejane Andréa
RA
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D009752:Nutritional Status; D010920:Placenta / Q000737:chemistry*; D049590:Postpartum Period; D011247:Pregnancy; D012016:Reference Values; D013048:Specimen Handling / Q000379:methods; D014801:Vitamin A / Q000032:analysis*
D014801:Vitamin A