Is there a trade-off between cognitive and motor recovery after  traumatic brain injury due to competition for limited  neural resources?
The status of neurorehabilitation for traumatic brain injury (TBI) is under active debate because of a dearth of research findings demonstrating effectiveness. This may be due, in part, to limitations in our understanding of basic mechanisms of cognitive and motor recovery,including those that might impede recovery. In this regard, we examined whether overall recovery following TBI might be undermined by competition between cognitive and motor functions for finite neural resources during recovery. In this preliminary study, 21 moderately and severely impaired patients were administered cognitive and motor assessments at 1, 4, and 12 months post-TBI, and recovery of cognitive and motor functions was measured using regression residuals. Negative correlations between recovery of cognitive versus motor functions were used as the index of competition. We found suggestive evidence that there may indeed be a trade-off between the recovery of cognitive and motor functions after TBI. Implications for rehabilitation are discussed.
Green
R E A
RE
Christensen
B
B
Melo
B
B
Monette
G
G
Bayley
M
M
Hebert
D
D
Inness
E
E
Mcilroy
W
W
D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000534:rehabilitation*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000534:rehabilitation*; D005500:Follow-Up Studies; D006801:Humans; D009048:Motor Skills; D026741:Physical Therapy Modalities; D020127:Recovery of Function; D012044:Regression Analysis; D012720:Severity of Illness Index; D016896:Treatment Outcome