title: Hereditary fructose intolerance and celiac disease: a novel genetic association.
abstract: OBJECTIVE
  Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI).
  
  
  METHODS
  We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients.
  
  
  RESULTS
  Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P<.02).
  
  
  CONCLUSIONS
  The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Ciacci
authors.forename: Daniela
authors.initials: D
authors.lastname: Gennarelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Esposito
authors.forename: Raffaella
authors.initials: R
authors.lastname: Tortora
authors.forename: Francesco
authors.initials: F
authors.lastname: Salvatore
authors.forename: Lucia
authors.initials: L
authors.lastname: Sacchetti
mesh_terms: D000328:Adult; D000367:Age Factors; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005633:Fructose Intolerance / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D015318:Fructose Metabolism, Inborn Errors / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D009154:Mutation; D010375:Pedigree; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens