SideLink: automated side-chain assignment of biopolymers from NMR data by relative-hypothesis-prioritization-based simulated logic.
Previously we published the development of AutoLink, a program to assign the backbone resonances of macromolecules. The primary limitation of this program has proven to be its inability to directly recognize spectral data, relying on the user to define peak positions in its input. Here, we introduce a new program for the assignment of side-chain resonances. Like AutoLink, this new program, called SideLink, uses Relative Hypothesis Prioritization to emulate "human" logic. To address the higher complexity of side-chain assignment problems, the RHP algorithm has itself been advanced, making it capable of processing almost any combinatorial logic problem. Additionally, SideLink directly examines spectral data, overcoming the need and limitations of prior data interpretation by users.
Masse
James E
JE
Laboratorium fur Physikalische Chemie, ETH Zurich, CH-8093, Zurich, Switzerland.
Keller
Rochus
R
Pervushin
Konstantin
K
D000465:Algorithms; D001185:Artificial Intelligence; D001331:Automation; D002247:Carbon Isotopes; D005998:Glycine / Q000737:chemistry; D007930:Leucine / Q000737:chemistry; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D011506:Proteins / Q000737:chemistry*; D012984:Software; D014584:User-Computer Interface
D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011506:Proteins; D007930:Leucine; D005998:Glycine