[The synthesis of immunomodulating peptide alloferon, the active component of the antiviral drug allokine-alpha].
Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total yield (40% vs. 17% for conventional synthesis in solution from the starting derivatives of the C-terminal dipeptide). The by-products formed during the synthesis of alloferon were identified.
Sidorova
M V
MV
Molokoedov
A S
AS
Kudriavtseva
E V
EV
Baldin
M I
MI
Frid
D A
DA
Ovchinnikov
M V
MV
Bespalova
Zh D
ZhD
Bushuev
V N
VN
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D010455:Peptides / Q000138:chemical synthesis*
D000276:Adjuvants, Immunologic; C510535:Alloferon; D000998:Antiviral Agents; D010455:Peptides