title: Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.
abstract: Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. The three polymorphisms -1082G/A, -819C/T, and -592C/A in the IL10 promoter were reported to influence IL10 transcription. We investigated whether these polymorphisms were associated with type 2 diabetes and related traits in a cohort of Italian Caucasians comprising 551 type 2 diabetic and 1,131 control subjects. The -819C/T and -592C/A polymorphisms were in perfect linkage disequilibrium (r(2) = 1.0). The -1082G/A polymorphism was not associated with type 2 diabetes or related traits. Although the -592C/A polymorphism was not associated with type 2 diabetes, nondiabetic homozygous carriers of the A allele showed increased BMI and insulin resistance and lower plasma IL-10 levels compared with the other genotypes. In the nondiabetic group, the ATA haplotype was associated with an increased risk for obesity (odds ratio 1.28 [95% CI 1.02-1.60]; P = 0.02). The ATA/ATA composite genotype was associated with an increased risk for obesity (1.96 [1.16-3.31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians.
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University Magna Graecia of Catanzaro, Via Tommaso Campanella, 88100 Catanzaro, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Scarpelli
authors.forename: Marina
authors.initials: M
authors.lastname: Cardellini
authors.forename: Francesco
authors.initials: F
authors.lastname: Andreozzi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Laratta
authors.forename: Marta Letizia
authors.initials: ML
authors.lastname: Hribal
authors.forename: Maria Adelaide
authors.initials: MA
authors.lastname: Marini
authors.forename: Vittorio
authors.initials: V
authors.lastname: Tassi
authors.forename: Renato
authors.initials: R
authors.lastname: Lauro
authors.forename: Francesco
authors.initials: F
authors.lastname: Perticone
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sesti
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044465:White People / Q000235:genetics
chemical_list: D016753:Interleukin-10