Coherent anti-Stokes Raman scattering imaging with a laser source delivered by a photonic crystal fiber.
We demonstrate laser-scanning coherent anti-Stokes Raman scattering (CARS) imaging with two excitation laser beams delivered by a large-mode-area photonic crystal fiber. The group-velocity dispersion and self-phase modulation effects are largely suppressed due to the large mode area of the fiber and the use of picosecond pulses. The fiber delivery preserves the signal level and image spatial resolution well. High-quality images of live spinal cord tissues are acquired using the fiber-delivered laser source. Our method provides a basic platform for developing a flexible and compact CARS imaging system.
Wang
Haifeng
H
Weldon School of Biomedical Engineering and Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Huff
Terry B
TB
Cheng
Ji-Xin
JX
D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D012542:Scattering, Radiation; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods