title: Connexins in the sinoatrial and atrioventricular nodes.
abstract: The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle). These functions have special requirements regarding electrical coupling and, therefore, expression of connexin isoforms. Electrical coupling in the center of the SAN should be weak to protect it from the inhibitory electrotonic influence of the more hyperpolarized non-pacemaking atrial muscle surrounding the SAN. However, for the SAN to be able to drive the atrial muscle, electrical coupling should be strong in the periphery of the SAN. Consistent with this, in the center of the SAN there is no expression of Cx43 (the principal connexin of the working myocardium) and little expression of Cx40, but there is expression of Cx45 and Cx30.2, whereas in the periphery of the SAN Cx43 as well Cx45 is expressed. In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.
authors.affiliation: Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester; UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Boyett
authors.forename: S
authors.initials: S
authors.lastname: Inada
authors.forename: S
authors.initials: S
authors.lastname: Yoo
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Tellez
authors.forename: I D
authors.initials: ID
authors.lastname: Greener
authors.forename: H
authors.initials: H
authors.lastname: Honjo
authors.forename: R
authors.initials: R
authors.lastname: Billeter
authors.forename: M
authors.initials: M
authors.lastname: Lei
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: I R
authors.initials: IR
authors.lastname: Efimov
authors.forename: H
authors.initials: H
authors.lastname: Dobrzynski
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001283:Atrioventricular Node / Q000502:physiology*; D018031:Connexin 43 / Q000378:metabolism / Q000502:physiology; D017630:Connexins / Q000378:metabolism / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D012849:Sinoatrial Node / Q000502:physiology*; D013617:Tachycardia, Supraventricular / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology; D000097003:Gap Junction alpha-5 Protein
chemical_list: D018031:Connexin 43; D017630:Connexins; D000097003:Gap Junction alpha-5 Protein; C510757:connexin 30.2, mouse; C082920:connexin 45