Genomic and epigenomic approaches to the study of X chromosome inactivation.
X chromosome inactivation represents a compelling example of chromosome-wide, long-range epigenetic gene-silencing in mammals. The cis- and trans-acting factors that establish and maintain the patterns and levels of gene expression from the active and inactive X chromosomes remain incompletely understood; however, the availability of the complete genomic sequence of the human X chromosome, together with complementary approaches that explore the computational biology, epigenetic modifications and gene expression-profiling along the chromosome, suggests that the features of the X chromosome that are responsible for its unique forms of gene regulation are increasingly amenable to experimental analysis.
Valley
Cory M
CM
Institute for Genome Sciences & Policy, Duke University, 101 Science Drive, CIEMAS 2376, Durham, NC 27708, USA.
Willard
Huntington F
HF
D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics*; D023281:Genomics; D006570:Heterochromatin / Q000235:genetics; D006801:Humans; D014960:X Chromosome / Q000235:genetics*; D049951:X Chromosome Inactivation / Q000235:genetics*
D006570:Heterochromatin