The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
Longoni
M
M
Department of Neurology, University of Milano-Bicocca, Monza, Monza, Italy. longonimarco@hotmail.com
Grond-Ginsbach
C
C
Grau
A J
AJ
Genius
J
J
Debette
S
S
Schwaninger
M
M
Ferrarese
C
C
Lichy
C
C
D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D005260:Female; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000502:physiology; D008239:Lysine / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020217:Vertebral Artery Dissection / Q000235:genetics*
D018799:Intercellular Adhesion Molecule-1; D018698:Glutamic Acid; D008239:Lysine