title: Postprandial hyperglycemia and cardiovascular disease.
abstract: OBJECTIVE
  To review the role of postprandial hyperglycemia in the development of type 2 diabetes mellitus and cardiovascular disease.
  
  
  METHODS
  The pathogenic mechanisms involved in the deterioration of glucose tolerance are discussed, and findings from relevant epidemiologic and clinical interventional studies are presented.
  
  
  RESULTS
  It is now well established that hyperglycemia is an independent risk factor for cardiovascular disease, with no apparent threshold. In clinical practice, glycemic exposure is measured by hemoglobin A1c levels. These values reflect the contribution of fasting and postprandial plasma glucose levels during the previous 2 to 3 months. Epidemiologic studies have indicated that, at hemoglobin A1c levels (5.5%) already associated with a substantially increased risk for cardiovascular mortality, fasting plasma glucose levels are generally normal. These observations implicate isolated postprandial hyperglycemia as a cardiovascular risk factor. Controlled interventional clinical trials have found that reduction of postprandial hyperglycemia decreases cardiovascular events or surrogates thereof.
  
  
  CONCLUSIONS
  Postprandial hyperglycemia should be considered a cardiovascular risk factor similar to hypertension, hyperlipidemia, and smoking; accordingly, it should be monitored and treated.
authors.affiliation: Department of Medicine, University of Rochester, New York, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Gerich
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D005215:Fasting; D005502:Food; D018149:Glucose Intolerance / Q000175:diagnosis; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin