An improved synthesis of psammaplin A.
The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.
Godert
Amy M
AM
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Angelino
Norman
N
Woloszynska-Read
Anna
A
Morey
Shannon R
SR
James
Smitha R
SR
Karpf
Adam R
AR
Sufrin
Janice R
JR
D045744:Cell Line, Tumor; D019175:DNA Methylation / Q000187:drug effects; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008780:Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D004220:Disulfides; D004791:Enzyme Inhibitors; C098378:psammaplin A; D014443:Tyrosine; D008780:Methyltransferases