title: Effect of allopurinol in chronic nonbacterial prostatitis: a double blind randomized clinical trial.
abstract: BACKGROUND
  The exact mechanism of chronic nonbacterial prostatitis has not been yet elucidated and the outcome with the current management is dismal. In this trial, we studied the effect of allopurinol in the treatment of this disease.
  
  
  METHODS
  In this randomized double blind controlled trial, a calculated sample size of 56 were grouped into "intervention group" who received allopurinol (100 mg tds for 3 months) with ofloxacin (200 mg tds) for 3 weeks (n = 29) and "control group" who received placebo tablets with ofloxacin (n = 27). Patients' scores based on the National Institute of Health Chronic Prostatitis Symptom Score were recorded before therapy and then every month during the study. A four-glass study was performed before intervention and after 3 months.
  
  
  RESULTS
  The 2 groups were similar regarding outcome variables. In the first month of study, a significant but similar improvement in symptom scores was observed in both groups. Microscopic examination of prostate massage and post-massage samples were also similar in both groups. No side effects due to allopurinol were observed in patients.
  
  
  CONCLUSIONS
  We did not find any advantage for allopurinol in the management of chronic prostatitis versus placebo in patients receiving routine antibacterial treatment.
authors.affiliation: Labbafinejad Hospital, Urology Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ziaee@hotmail.com
authors.forename: Amir M
authors.initials: AM
authors.lastname: Ziaee
authors.forename: Hamed
authors.initials: H
authors.lastname: Akhavizadegan
authors.forename: Mojgan
authors.initials: M
authors.lastname: Karbakhsh
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000627:therapeutic use*; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D011472:Prostatitis / Q000188:drug therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary; D000963:Antimetabolites; D000493:Allopurinol; D015242:Ofloxacin