Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats.
Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.
Lee
Seulki
S
College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul 151-742, Korea.
Kim
Sang Kyoon
SK
Lee
Dong Yun
DY
Chae
Su Young
SY
Byun
Youngro
Y
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D001682:Biological Availability; D001702:Biopharmaceutics; D002412:Cations; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D019946:Propylene Glycol / Q000737:chemistry; D051381:Rats; D012997:Solvents / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001647:Bile Acids and Salts; D002412:Cations; D012997:Solvents; D019946:Propylene Glycol; D002443:Ceftriaxone