Are repeated doses of buprenorphine detrimental to postoperative recovery after laparotomy in rats?
Buprenorphine is a widely used analgesic for relief of postoperative pain in rats. The effect of repeated doses of buprenorphine throughout the postoperative pain and stress response is unknown. This investigation tested the hypotheses that (a) daily analgesic doses of buprenorphine for 7 d ameliorate the stress response after laparotomy in rats and (b) preoperative buprenorphine better ameliorates the response than do peri- and postoperative administration. Postoperative effects on body weight, daily food and water consumption, and daily fecal and urinary outputs were monitored in groups of rats treated for 7 d with analgesic doses of buprenorphine initiated at different time points relative to the time of laparotomy. Analgesic doses of buprenorphine had no effect on the study parameters in healthy unoperated rats. Daily injection of buprenorphine delayed the time at which the preoperative body weight was restored without decreasing the postoperative changes in daily food consumption, water intake, and fecal and urinary outputs in the operated rats. The effects of daily analgesic doses of buprenorphine for 7 d on body weight, daily food, and water consumption, and fecal and urinary outputs were minimal and less statistically significant than the changes caused by surgery itself. However, this dosing regimen seems to delay the restoration of body weight after abdominal surgery in rats.
Bomzon
Arieh
A
Department of Pharmacology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. bomzon@tx.technion.ac.il
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D013505:Digestive System Surgical Procedures; D004334:Drug Administration Schedule; D005260:Female; D010149:Postoperative Pain / Q000517:prevention & control*; D011182:Postoperative Care; D051381:Rats; D017208:Rats, Wistar
D000701:Analgesics, Opioid; D002047:Buprenorphine