Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure.
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
Nakamura
Hitomi
H
Division of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
Kimura
Tadashi
T
Koyama
Shinsuke
S
Ogita
Kazuhide
K
Tsutsui
Tateki
T
Shimoya
Koichiro
K
Taniguchi
Takeshi
T
Koyama
Masayasu
M
Kaneda
Yasufumi
Y
Murata
Yuji
Y
D000818:Animals; D004195:Disease Models, Animal; D010064:Embryo Implantation; D020964:Embryo Loss / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007246:Infertility / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*
D050796:STAT3 Transcription Factor