title: Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala.
abstract: Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha.
authors.affiliation: Pharmacognosy Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomashi 1-78, Tokushima 770-8505, Japan.
authors.forename: Freddy
authors.initials: F
authors.lastname: Ramos
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawazoe
authors.forename: Coralia
authors.initials: C
authors.lastname: Osorio
authors.forename: Carmenza
authors.initials: C
authors.lastname: Duque
authors.forename: Ricardo
authors.initials: R
authors.lastname: Acuña
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Sato
authors.forename: Masato
authors.initials: M
authors.lastname: Okamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Oshikawa
authors.forename: Sharif Uddin
authors.initials: SU
authors.lastname: Ahmed
mesh_terms: D000114:Acetylene / Q000737:chemistry* / Q000494:pharmacology; D028041:Centella / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry*; D002554:Cerebrosides / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D002518:Ceramides; D002554:Cerebrosides; D016207:Cytokines; D007166:Immunosuppressive Agents; D000114:Acetylene