title: Relationship between central corneal thickness and localized retinal nerve fiber layer defect in normal-tension glaucoma.
abstract: OBJECTIVE
  To determine whether central corneal thickness (CCT) is related to the extent of localized retinal nerve fiber layer (RNFL) defect at the initial examination of normal-tension glaucoma (NTG) patients.
  
  
  METHODS
  Seventy-five eyes of 75 NTG patients showing localized RNFL defects on RNFL photographs and corresponding visual field defects at the initial visit to a glaucoma specialist were selected for this study. All participants completed refraction, Goldmann applanation tonometry, CCT measurement, stereoscopic disc photography, RNFL photography, and automated perimetry. Each patient's age, spherical equivalent, intraocular pressure, CCT, approximation of the RNFL defect to the fovea (angle alpha), circumferential width of the RNFL defects (angle beta), horizontal and vertical cup-to-disc ratios, and mean deviation of visual field were analyzed.
  
  
  RESULTS
  In univariate and multivariate analyses, lower CCT was significantly associated with increased horizontal and vertical cup-to-disc ratios, decreased angle alpha, and increased angle beta. For a decrease of 10 microm of CCT, horizontal and vertical cup-to-disc ratios increased by 0.020, angle alpha decreased by 1.58 degrees, and angle beta increased by 1.71 degrees, respectively.
  
  
  CONCLUSIONS
  CCT is a significant factor in predicting the extent of localized RNFL defect at the initial examination of NTG patients.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hyuk Jin
authors.initials: HJ
authors.lastname: Choi
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
authors.forename: Seung-Sik
authors.initials: SS
authors.lastname: Hwang
mesh_terms: D000328:Adult; D000368:Aged; D001837:Body Weights and Measures; D003315:Cornea / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014065:Tonometry, Ocular; D014463:Ultrasonography; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields