title: A case of fulminant post-transplant lymphoproliferative disorder and septicemia.
abstract: The fulminant form of post-transplant lymphoproliferative disorder (PTLD) is very uncommon and occurs in approximately 1% of PTLD patients. Approximately 85% of these lesions are of B-cell origin, and most of them are associated with Epstein-Barr virus infection. Fulminant PTLD is frequently associated with a systemic inflammatory response syndrome, and may be difficult to differentiate from septicemia. We describe the case of a 59-yr-old man who suffered from prolonged septicemia in the immediate post-transplant period, and presented again four months after cardiac transplantation with fever, painful liver edge and gastrointestinal bleeding. The diagnosis of fulminant PTLD with advanced multiorgan infiltration by a diffuse large-cell lymphoma of B-cell phenotype was made. During treatment with rituximab, the patient died from Enterococcus faecium septicemia. The sequence of septicemia, PTLD and, finally again, septicemia is an unusual challenge and urges for an aggressive diagnostic approach, where markers like procalcitonin may aid in the discrimination of fulminant PTLD from septicemia.
authors.affiliation: Department of Internal Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria. ghazaleh.gouya@meduniwien.ac.at
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Gouya
authors.forename: Gabriele
authors.initials: G
authors.lastname: Hartmann
authors.forename: Peter
authors.initials: P
authors.lastname: Faè
authors.forename: Martina
authors.initials: M
authors.lastname: Tauber
authors.forename: Hannes
authors.initials: H
authors.lastname: Holzmüller
authors.forename: Werner
authors.initials: W
authors.lastname: Benzer
authors.forename: Alois
authors.initials: A
authors.lastname: Lang
authors.forename: Antonius
authors.initials: A
authors.lastname: Schuster
authors.forename: Heinz
authors.initials: H
authors.lastname: Drexel
authors.forename: Felix Albert
authors.initials: FA
authors.lastname: Offner
mesh_terms: D001344:Autopsy; D016984:Enterococcus faecium; D017809:Fatal Outcome; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis; D018805:Sepsis / Q000209:etiology*; D017211:Treatment Failure