title: Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25.
abstract: Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 microM, respectively.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Kim
authors.forename: Ichiji
authors.initials: I
authors.lastname: Namatame
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002788:Cholesterol Esters / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D002788:Cholesterol Esters; D004224:Diterpenes; D000960:Hypolipidemic Agents; D007211:Indoles; D012717:Sesquiterpenes; D014280:Triglycerides; C510263:sespendole