Regulation of DNA repair by ubiquitylation.
The process of ubiquitylation is best known for its role in targeting proteins for degradation by the proteasome. However, recent studies of DNA-repair and DNA-damage-response pathways have significantly broadened the scope of the role of ubiquitylation to include non-proteolytic functions of ubiquitin. These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins.
Huang
Tony T
TT
Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.
D'Andrea
Alan D
AD
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D005199:Fanconi Anemia / Q000378:metabolism; D006801:Humans; D025842:SUMO-1 Protein / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*
D025842:SUMO-1 Protein; D025801:Ubiquitin; D004247:DNA