title: Genetic variations of the Plasmodium vivax dihydropteroate synthase gene.
abstract: Dihydropteroate synthase gene of Plasmodium vivax was recently identified. In the present study, the sequences of the dyhydropteroate synthase gene of 68 P. vivax isolates from various geographic areas were compared. Sequencing revealed limited polymorphism at codons 383 and 553 in all analyzed samples. Interstrain analysis showed several genotypic variations in the tandem repeats domain which produce length polymorphism between different parasite isolates.
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy. menegonm@iss.it
authors.forename: Michela
authors.initials: M
authors.lastname: Menegon
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Majori
authors.forename: Carlo
authors.initials: C
authors.lastname: Severini
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016054:DNA, Protozoan / Q000235:genetics; D004094:Dihydropteroate Synthase / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy*; D008969:Molecular Sequence Data; D010966:Plasmodium vivax / Q000201:enzymology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D016054:DNA, Protozoan; D004094:Dihydropteroate Synthase