title: Childhood cutaneous tuberculosis: a 20-year retrospective study in Tunis.
abstract: Despite prevention programs, tuberculosis is still endemic in developing countries. We assessed the epidemiologic and clinical profiles of childhood cutaneous tuberculosis in our dermatology department from 1981 to 2000 and compared it to previous Tunisian reports and to the relevant literature. This is a retrospective study over a 20-year period (1981-2000) in a large teaching hospital of the capital. Patients included were below age 15 years. Diagnosis was based upon clinical examination, tuberculin reaction, histopathology and response to antitubercular therapy. There were 26 patients with cutaneous tuberculosis, 0.1 percent of the total number of dermatology outpatients for that time period. Of these 26, seven (27 %) were immunocompetent. There were four boys and three girls and the mean age was 9.5 years. Three patients had lupus vulgaris, three had scrofuloderma, and one child had orificial tuberculosis. Six out of seven children were BCG vaccinated. There was no family history of tuberculosis. The Mantoux reaction was positive in six children. There was no systemic organ involvement in all cases. All patients were treated successfully with triple or quadruple anti-tubercular drugs for 4-11 months. Compared to a previous Tunisian report conducted over an 8-year period in the seventies, the incidence of childhood cutaneous tuberculosis has decreased. In that report, scrofuloderma was the most frequent form. Currently the incidence of lupus vulgaris has reached that of scrofuloderma, demonstrating the increase of the clinical pattern associated with strong immunity. All children had localized disease and responded to antimycobcterial chemotherapy.
authors.affiliation: Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia. rym.benmously@rns.tn
authors.forename: Rym Benmously
authors.initials: RB
authors.lastname: Mlika
authors.forename: Jihen
authors.initials: J
authors.lastname: Tounsi
authors.forename: Samy
authors.initials: S
authors.lastname: Fenniche
authors.forename: Khaoula
authors.initials: K
authors.lastname: Hajlaoui
authors.forename: Hayet
authors.initials: H
authors.lastname: Marrak
authors.forename: Inçaf
authors.initials: I
authors.lastname: Mokhtar
mesh_terms: D000152:Acne Vulgaris / Q000150:complications; D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D014382:Tuberculosis, Cutaneous / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D014416:Tunisia
chemical_list: D000995:Antitubercular Agents