title: Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients.
abstract: BACKGROUND
  Critically ill patients are predisposed to oxyhemoglobin desaturation during intubation.
  
  
  OBJECTIVE
  To find out whether noninvasive ventilation (NIV), as a preoxygenation method, is more effective at reducing arterial oxyhemoglobin desaturation than usual preoxygenation during orotracheal intubation in hypoxemic, critically ill patients.
  
  
  METHODS
  Prospective randomized study performed in two surgical/medical intensive care units (ICUs). Preoxygenation was performed, before a rapid sequence intubation, for a 3-min period using a nonrebreather bag-valve mask (control group) or pressure support ventilation delivered by an ICU ventilator through a face mask (NIV group) according to the randomization.
  
  
  RESULTS
  The control (n = 26) and NIV (n = 27) groups were similar in terms of age, disease severity, diagnosis at admission, and pulse oxymetry values (Sp(O(2))) before preoxygenation. At the end of preoxygenation, Sp(O(2)) was higher in the NIV group as compared with the control group (98 +/- 2 vs. 93 +/- 6%, p < 0.001). During the intubation procedure, the lower Sp(O(2)) values were observed in the control group (81 +/- 15 vs. 93 +/- 8%, p < 0.001). Twelve (46%) patients in the control group and two (7%) in the NIV group had an Sp(O(2)) below 80% (p < 0.01). Five minutes after intubation, Sp(O(2)) values were still better in the NIV group as compared with the control group (98 +/- 2 vs. 94 +/- 6%, p < 0.01). Regurgitations (n = 3; 6%) and new infiltrates on post-procedure chest X ray (n = 4; 8%) were observed with no significant difference between groups.
  
  
  CONCLUSIONS
  For the intubation of hypoxemic patients, preoxygenation using NIV is more effective at reducing arterial oxyhemoglobin desaturation than the usual method.
authors.affiliation: Intensive Care Unit, Department of Anesthesiology, DAR B CHU de Montpellier, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Baillard
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Fosse
authors.forename: Mustapha
authors.initials: M
authors.lastname: Sebbane
authors.forename: Gérald
authors.initials: G
authors.lastname: Chanques
authors.forename: Francçois
authors.initials: F
authors.lastname: Vincent
authors.forename: Patricia
authors.initials: P
authors.lastname: Courouble
authors.forename: Yves
authors.initials: Y
authors.lastname: Cohen
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Eledjam
authors.forename: Frédéric
authors.initials: F
authors.lastname: Adnet
authors.forename: Samir
authors.initials: S
authors.lastname: Jaber
mesh_terms: D000368:Aged; D016638:Critical Illness; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000628:therapy*; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies; D012107:Research Design; D012121:Respiration, Artificial
chemical_list: D010100:Oxygen