title: A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis.
abstract: We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.
authors.affiliation: Department of Surgery, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, 152-8902, Japan. hiroyatakeuchi@aol.com
authors.forename: Hiroya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Ken
authors.initials: K
authors.lastname: Futamata
authors.forename: Arafumi
authors.initials: A
authors.lastname: Maeshima
authors.forename: Shigemichi
authors.initials: S
authors.lastname: Hirose
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shimada
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Jo
authors.initials: J
authors.lastname: Tokuyama
authors.forename: Koji
authors.initials: K
authors.lastname: Osumi
authors.forename: Shinya
authors.initials: S
authors.lastname: Kishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hojo
authors.forename: Shiei
authors.initials: S
authors.lastname: Kim
authors.forename: Norihito
authors.initials: N
authors.lastname: Wada
authors.forename: Takashi
authors.initials: T
authors.lastname: Oishi
authors.forename: Yoh
authors.initials: Y
authors.lastname: Isobe
authors.forename: Shunji
authors.initials: S
authors.lastname: Ikeuchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kubochi
authors.forename: Sumio
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery