Gene transfer approaches for gynecological diseases.
Gene transfer presents a potentially useful approach for the treatment of diseases refractory to conventional therapies. Various preclinical and clinical strategies have been explored for treatment of gynecological diseases. Given the direst need for novel treatments, much of the work has been performed with gynecological cancers and ovarian cancer in particular. Although the safety of many approaches has been demonstrated in early phase clinical trials, efficacy has been mostly limited so far. Major challenges include improving gene transfer vectors for enhanced and selective delivery and achieving effective penetration and spread within advanced and complex tumor masses. This review will focus on current and developmental gene transfer applications for gynecological diseases.
Raki
Mari
M
Cancer Gene Therapy Group, Rational Drug Design Program, University of Helsinki, 00014 Helsinki, Finland.
Rein
Daniel T
DT
Kanerva
Anna
A
Hemminki
Akseli
A
D000256:Adenoviridae / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002986:Clinical Trials as Topic; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D005260:Female; D041722:Genes, Transgenic, Suicide; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D005822:Genetic Vectors; D005831:Genital Diseases, Female / Q000628:therapy*; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000628:therapy; D050130:Oncolytic Virotherapy / Q000379:methods; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000628:therapy*; D017978:Receptors, Growth Factor / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism
C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D017978:Receptors, Growth Factor; D011991:Receptors, Virus