title: Does music exposure during chemotherapy improve quality of life in early breast cancer patients? A pilot study.
abstract: BACKGROUND
  Adjuvant chemotherapy is associated with poor quality of life (qol) in breast cancer patients. We tested the effect of listening to music during chemotherapy on quality of life in these patients.
  
  
  METHODS
  We tested in a prospective cohort the changes in qol scores as assessed by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), and the influence of listening to non-preferred music at the chemotherapy unit on these parameters in a mixed linear model by repeated measures analysis of variance (RMANOVA).
  
  
  RESULTS
  For the whole cohort, musical intervention was not associated with a change in any dimension of quality of life. However; the music effect significantly interacted with patient age; patients > 45 years old had improved insomnia and appetite loss scores after musical intervention (F = 6.76, P = 0.019 and F = 11.22, P = 0.004, respectively).
  
  
  CONCLUSIONS
  Our results show that brief, non-preferred music exposure at the time of chemotherapy administration does not improve quality of life in patients with early breast cancer. Nonetheless, there is still a possibility that a subgroup will benefit from this approach as suggested by the interaction of the music effect with patient age.
authors.affiliation: Akdeniz University Medical Faculty, Dept. of Medical Oncology, Antalya, Turkey. hbozcuk@antnet.net.tr
authors.forename: Hakan
authors.initials: H
authors.lastname: Bozcuk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Artac
authors.forename: Arzu
authors.initials: A
authors.lastname: Kara
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozdogan
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Sualp
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Topcu
authors.forename: Ayse
authors.initials: A
authors.lastname: Karaagacli
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildiz
authors.forename: Burhan
authors.initials: B
authors.lastname: Savas
mesh_terms: D000328:Adult; D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001066:Appetite; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009147:Music Therapy; D010865:Pilot Projects; D011446:Prospective Studies; D007319:Sleep Initiation and Maintenance Disorders / Q000517:prevention & control; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents