[Aging and age-related macular degeneration].
Aging is a common feature of biological changes in the eye, especially in the retina. It is recognized that the pathogenesis of age-related macular degeneration (AMD) involves changes of RPE-Bruch membrane and choroid capillaries complex, which includes function and structure abnormal in the complex accompanied with aging processes. Aging may be an important event to contribute to the pathogenesis of AMD, but aging dose not directly led to the occurrence of AMD, multifactor is involved in the initiation of the pathogenesis of AMD. Therefore, this review is summarizing the latest concepts of the rale of aging in the occurrence of AMD.
He
Shi-kun
SK
Department of Ophthalmology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA. shikunhe@usc.edu
Jiang
Yan
Y
D000375:Aging / Q000502:physiology*; D016570:Bruch Membrane / Q000473:pathology; D002829:Choroid / Q000098:blood supply; D006801:Humans; D008268:Macular Degeneration / Q000473:pathology*; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology*