Lichenoid and granulomatous stomatitis: an entity or a non-specific inflammatory process?
BACKGROUND
The presence of lichenoid or granulomatous inflammation in an oral mucosal biopsy usually suggests a distinct range of diagnostic possibilities. However, the presence of both patterns of inflammation in the same biopsy is uncommon.


METHODS
A clinico-pathological study of six patients.


RESULTS
All the patients in this study presented with similar mucosal lesions of the upper lip. Microscopically the lesions were characterized by the presence of lichenoid inflammation with concomitant granulomatous inflammation. The lesions were persistent and refractory to treatment with steroid medications, but remained localized and did not appear to herald the onset of systemic inflammatory or neoplastic disease.


CONCLUSIONS
We propose the designation 'lichenoid and granulomatous stomatitis' for the cases described in this study. The clinico-pathological features of a subset of these cases suggest an unusual drug eruption.
Robinson
C Max
CM
Department of Oral and Dental Science, University of Bristol, Bristol, UK. max.robinson@bristol.ac.uk
Oxley
Jon D
JD
Weir
Justin
J
Eveson
John W
JW
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001262:Atenolol / Q000009:adverse effects; D004338:Drug Combinations; D003875:Drug Eruptions / Q000473:pathology; D004342:Drug Hypersensitivity / Q000150:complications; D005260:Female; D006099:Granuloma / Q000473:pathology; D006801:Humans; D017676:Lichen Planus, Oral / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009288:Naproxen / Q000009:adverse effects; D017257:Ramipril / Q000009:adverse effects; D013280:Stomatitis / Q000145:classification* / Q000209:etiology / Q000473:pathology*
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D001262:Atenolol; D009288:Naproxen; D017257:Ramipril