Polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and preliminary data about their combined administration.
The regeneration potential of the adult mammalian central nervous system (CNS) is very modest, due to, among other factors, the presence of either a glial scar, or myelin-associated regeneration inhibitors such as Nogo-A, MAG and OMgp, which all interact with the same receptor (NgR). After a brief review of the key proteins (Rho and PKC) implicated in NgR-mediated signalling cascades, we will tackle the implications of cAMP and Arginase I in overcoming myelin growth-inhibitory influence, and then will focus on the effects of polyamines and aminoguanidine to propose (and to briefly support this proposal by our own preliminary data) that their association might be a potent way to enable functionally-relevant regeneration in the adult mammalian CNS.
Schimchowitsch
Sarah
S
Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS--Université Louis Pasteur, IFR 37 Neurosciences, Strasbourg, France.
Cassel
Jean-Christophe
JC
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008322:Mammals; D009186:Myelin Sheath / Q000378:metabolism; D011073:Polyamines / Q000627:therapeutic use*; D020127:Recovery of Function / Q000187:drug effects*
D004791:Enzyme Inhibitors; D006146:Guanidines; D011073:Polyamines; C004479:pimagedine