Multiple periungual pyogenic granulomas following systemic 5-fluorouracil.
A 65-year-old man presented with a 7-month history of eight bleeding periungual lesions on both feet. The clinical diagnosis of multiple pyogenic granulomas was confirmed by histological examination. Historically, the pyogenic granulomas appeared 3 months after commencing 5-fluorouracil chemotherapy for rectal carcinoma, suggesting a possible causative relationship. Chemotherapy was ceased by the supervising oncologist. Resolution occurred after two lesions had been treated with curettage and diathermy, and the remaining lesions with occlusive dressings over Kenacomb ointment (triamcinolone acetonide 0.1%, neomycin sulphate 0.25%, gramicidin 0.025%, nystatin 100,000 U/g) topically twice daily for a period of 3 months.
Curr
Nathan
N
Department of Dermatology, The Alfred Hospital, Prahran, Victoria, Australia. nathancurr@hotmail.com
Saunders
Helen
H
Murugasu
Anand
A
Cooray
Prasad
P
Schwarz
Max
M
Gin
Douglas
D
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D017789:Granuloma, Pyogenic / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D014034:Toes / Q000473:pathology
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil