title: Skin angiosarcoma arising in an irradiated breast: case-report and literature review.
abstract: BACKGROUND
  Angiosarcoma (AS) is a rare, invasive malignancy originating from endothelial cells caused by many different clinical situations. AS following radiotherapy for breast cancer after conservative surgery is a rare but well-known association.
  
  
  OBJECTIVE
  The aim of this article is to describe a case of AS after breast conserving surgery and to review the literature to date.
  
  
  RESULTS
  We report the case of an 84-year-old woman who developed AS four years after she was subjected to quadrantectomy for invasive ductal cancer, followed by 30 tangent field radiotherapy sessions. She presented with a one-month history or red papular skin eruptions on the operated breast. Skin lesions were submitted for biopsy, and they were positive for AS. The patients was subjected to surgical excision of the remaining breast including all AS lesions. She is alive with no evidence of disease after 10 months follow-up.
  
  
  CONCLUSIONS
  Post-radiotherapy AS is rare neoplasm, but it should be considered in the case of patients with red lesions after breast conserving surgery and adjuvant radiotherapy.
authors.affiliation: St. Orsola-Malpighi University Hospital, Via Massarenti, Bologna, Italy. fcatena@aosp.bo.it
authors.forename: Fausto
authors.initials: F
authors.lastname: Catena
authors.forename: Donatella
authors.initials: D
authors.lastname: Santini
authors.forename: Salomone
authors.initials: S
authors.lastname: Di Saverio
authors.forename: Annamaria
authors.initials: A
authors.lastname: Laneve
authors.forename: Luca
authors.initials: L
authors.lastname: Ansaloni
authors.forename: Tommaso
authors.initials: T
authors.lastname: Fogacci
authors.forename: Stefano
authors.initials: S
authors.lastname: Gagliardi
authors.forename: Filippo
authors.initials: F
authors.lastname: Gazzotti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Guidi
authors.forename: Angelo
authors.initials: A
authors.lastname: De Cataldis
authors.forename: Mario
authors.initials: M
authors.lastname: Taffurelli
mesh_terms: D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008408:Mastectomy; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery