Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation.
The Fc epsilonRI-dependent activation of nuclear factor (NF)kappaB is key for mast-cell cytokine production. The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes. A recent study reveals that the Bcl10-Malt1 complex promotes mast-cell interleukin-6 and tumor necrosis factor production, independent of degranulation, eicosanoid secretion or survival. The new findings place this complex at the forefront in discriminating between signals required for cytokine production and those required for mast-cell degranulation and eicosanoid production.
Rivera
Juan
J
Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. juan_rivera@nih.gov
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D015550:Cell Degranulation / Q000502:physiology*; D016207:Cytokines / Q000096:biosynthesis*; D015777:Eicosanoids / Q000096:biosynthesis*; D006801:Humans; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D051179:Plakins / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D015777:Eicosanoids; D051179:Plakins