Anti Kell allo-antibody in a thalassaemic.
We describe a case of incidental detection of anti Kell antibody in a child with transfusion dependent thalassaemia. Kell antibody detection may be missed by routine indirect antiglobulin test (IAT) crossmatch procedure because of low prevalence of Kell antigen in the general population. A false negative result can be avoided by using sensitive cross matching techniques and screening cells representing antigens in homozygous state, against all clinically significant antibodies. A transfusion alert card describing the nature of antibody and future transfusion policy should be given to such allo-immunized patients.
Thakral
Beenu
B
Department of Transfusion Medicine and Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh. beenschor@yahoo.co.in
Saluja
Karan
K
Sharma
Ratti Ram
RR
Marwaha
Neelam
N
Marwaha
R K
RK
D000293:Adolescent; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007626:Kell Blood-Group System / Q000276:immunology*; D013789:Thalassemia / Q000150:complications* / Q000276:immunology*
D007518:Isoantibodies; D007626:Kell Blood-Group System