Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis.
Two new sulfated triterpene glycosides, philinopside E (1) and F (2), have been isolated from the sea cucumber Pentacta quadrangularis. Their structures have been established by extensive spectral analysis (NMR and MS) and chemical evidence. Glycoside 1 showed significant cytotoxicity (Ed(50) 0.75-3.50 microg mL(-1)) against ten tumor cell lines.
Zhang
Shi-Long
SL
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P.R. China.
Li
Ling
L
Yi
Yang-Hua
YH
Sun
Peng
P
D000818:Animals; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity
D006027:Glycosides; C512676:Philinopside E; C512677:Philinopside F; D014315:Triterpenes