Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.
Chen
Cheng-Chi
CC
Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.
Shiao
Young-Ji
YJ
Lin
Ruei-Da
RD
Shao
Yi-Yuan
YY
Lai
Min-Nan
MN
Lin
Chun-Ching
CC
Ng
Lean-Teik
LT
Kuo
Yueh-Hsiung
YH
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D020072:Polyporales / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013624:Taiwan
D004224:Diterpenes; D018696:Neuroprotective Agents