[Role of urinary basic fibroblast growth factor in differentiating hemangiomas from vascular malformation].
OBJECTIVE
To investigate a novel method to differentiate hemangioma from vascular malformation, to stage hemangiomas and to monitor the efficacy of management for hemangioma.


METHODS
The urinary basic fibroblast growth factor (bFGF) concentration of 144 cases (including 69 cases of proliferating hemangiomas, 41 cases of involuting hemangiomas, 23 cases of vascular malformations and 11 negative controls) was examined using enzyme linked immunosorbent assay (ELISA).


RESULTS
The differences of urinary bFGF concentration among proliferating hemangiomas, involuting hemangiomas, vascular malformations and negative control were all significant, while the differences between the latter three groups were not significant.


CONCLUSIONS
Our findings suggest that examination of urinary bFGF concentration using ELISA technique is helpful in differentiating hemangioma from vascular malformation, staging hemangiomas and dynamically monitoring the efficacy of treatment for hemangiomas. Our results probably shed new light on the potential pathogenesis of hemangiomas and vascular malformation.
Zhang
Li
L
Department of Plastic and Reconstructive Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Lin
Xiao-xi
XX
Qi
Zuo-liang
ZL
Dong
Jia-sheng
JS
Zou
Li-jian
LJ
Dai
Chuan-chang
CC
Li
Wei
W
Wang
Wei
W
D001165:Arteriovenous Malformations / Q000175:diagnosis* / Q000652:urine; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016222:Fibroblast Growth Factor 2 / Q000652:urine*; D006391:Hemangioma / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
D016222:Fibroblast Growth Factor 2