DNA repair: DNA polymerase zeta and Rev1 break in.
DNA polymerase zeta and Rev1 play key roles in replication past DNA lesions. New work shows that the yeast checkpoint kinase Mec1 recruits a complex consisting of polymerase zeta and Rev1 to DNA double-strand breaks. This study highlights the role of polymerases that mediate translesion synthesis in the response to DNA double-strand breaks.
Kolas
Nadine K
NK
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Durocher
Daniel
D
D004260:DNA Repair / Q000502:physiology*; D004271:DNA, Fungal / Q000096:biosynthesis*; D004259:DNA-Directed DNA Polymerase / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D009713:Nucleotidyltransferases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D000099270:Y-Family DNA Polymerases
D004271:DNA, Fungal; D004259:DNA-Directed DNA Polymerase; D047908:Intracellular Signaling Peptides and Proteins; D009713:Nucleotidyltransferases; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins; C088937:MEC1 protein, S cerevisiae; C425929:DNA polymerase zeta; C100951:REV1 protein, S cerevisiae; D000099270:Y-Family DNA Polymerases