Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris.
This study examined whether coronary focal vasospasm occurs in a nonuniform distribution within the coronary tree and whether a longitudinal plaque distribution pattern is present in patients with vasospastic angina using 3-dimensional intravascular ultrasound analysis. Of 121 patients with clinically suspected angina without fixed stenosis in the coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection. Most focal vasospasms occurred in the proximal third of the coronary arteries (proximal 28, mid 8, distal 6, p <0.01), corresponding to the historical high-risk zones for acute coronary occlusion. More plaque burden also existed in the proximal third of the coronary arteries in patients with focal vasospasm.
Koizumi
Tomomi
T
Center for Research in Cardiovascular Interventions, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Yokoyama
Masaki
M
Namikawa
Susumu
S
Kuriyama
Nehiro
N
Nameki
Mizuo
M
Nakayama
Takashi
T
Kaneda
Hideaki
H
Sudhir
Krishnankutty
K
Yock
Paul G
PG
Komiyama
Nobuyuki
N
Fitzgerald
Peter J
PJ
D000787:Angina Pectoris / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004562:Electrocardiography; D004874:Ergonovine; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018084:Ultrasonography, Interventional; D014662:Vasoconstrictor Agents
D014662:Vasoconstrictor Agents; D004874:Ergonovine