Role of stent design and coatings on restenosis and thrombosis.
More than 15 years have passed since stent technology was introduced by Sigwart et al. [U. Sigwart, J. Puel, V. Mirkovitch, F. Joffe, et al. Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N. Engl. J. Med. 316 (1987) 701-706.] among interventional cardiologists. Recently drug eluting stents have assumed dominance in the interventional world as positive trial results revealed their efficacy for preventing restenosis. Stent design, delivery-vehicle materials, and drug properties affect the function of these stents. Stainless steel stents with tubular and multicellular design have proven superior to coil or hybrid stent models. This chapter describes stents which have subtle influences of modular design, metal coverage, strut thickness, strut shape, surface smoothness, and coating materials like an alloy composition.
Hara
Hidehiko
H
Minnesota Cardiovascular Research Institute, Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, 920 East 28th Street Suite 620, Minneapolis, MN, 55407, USA.
Nakamura
Masato
M
Palmaz
Julio C
JC
Schwartz
Robert S
RS
D001698:Biomedical Engineering / Q000379:methods* / Q000639:trends; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use*; D023903:Coronary Restenosis / Q000517:prevention & control*; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D013927:Thrombosis / Q000517:prevention & control*
D020099:Coated Materials, Biocompatible