Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia.
A 38-year-old female with chronic myeloid leukemia underwent an allogeneic bone marrow transplantation from her full-matched brother. Eleven months later, she readmitted with an acute leukemia that was shown to be of donor origin. The patient never achieved a remission even after chemotherapies with cytarabine and mitoxantrone, donor lymphocyte infusion, and second allogeneic peripheral blood stem cell transplantation. Donor cell leukemia (DCL) is sometimes misdiagnosed as relapse by clinicians and the real incidence may be higher than expected. Cytogenetic and molecular techniques may be helpful to clarify the issue of the leukemia. The current case is another case of DCL reported in the literature after an allogeneic transplant for a kind of leukemia.
Ataergin
Selmin
S
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey.
Arpaci
Fikret
F
Cetin
Turker
T
Guran
Sefik
S
Yakicier
Cengiz
C
Beyzadeoglu
Murat
M
Ozet
Ahmet
A
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D041322:Chromosomes, Human, Y; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000209:etiology* / Q000235:genetics / Q000601:surgery*; D008297:Male; D010677:Philadelphia Chromosome; D014019:Tissue Donors; D018183:Transplantation Chimera / Q000235:genetics*; D014184:Transplantation, Homologous