title: Subcellular localization of epidermal growth factor receptor in human submandibular gland.
abstract: The subcellular distribution of the epidermal growth factor receptor (EGFr) was demonstrated in the normal human submandibular gland by means of immunogold cytochemistry. EGFr labelling appeared in both acinar and ductal cells, where strong immunoreactivity was associated with a tubulovesicular system near the basolateral surfaces. In addition, groups of reactive vesicles were highlighted among secretory granules of both serous and mucous cells and at the apex of ductal cells. Basolateral vesicles were interpreted as being a result of EGFr internalization after activation by an exogenous ligand, although the functional meaning of those located apically remains unclear.
authors.affiliation: Dipartimento di Citomorfologia, Università di Cagliari, Italy. lantini@unica.it
authors.forename: M S
authors.initials: MS
authors.lastname: Lantini
authors.forename: M
authors.initials: M
authors.lastname: Cossu
authors.forename: M
authors.initials: M
authors.lastname: Isola
authors.forename: M
authors.initials: M
authors.lastname: Piras
authors.forename: M
authors.initials: M
authors.lastname: Piludu
mesh_terms: D000368:Aged; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D042541:Intracellular Space / Q000737:chemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D013363:Submandibular Gland / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D066246:ErbB Receptors