Case-control study of oropharyngeal cancer.
BACKGROUND
In order to test some hypotheses of risk factors for oropharyngeal cancer (neoplasm of base of tongue, palate and tonsils) matched case-control study was conducted in Belgrade, Serbia and Montenegro, during the period 1998-2000.


METHODS
Study comprised 100 incidence cases with oropharyngeal cancer and 100 controls with some non-malignant diseases of head and neck.


RESULTS
According to multivariate analysis, ever smoking, interaction between smoking and alcohol consumption, and occupational exposure to wood dust were found to be independent risk factors for oropharyngeal cancer (odds ratio-OR=5.10 95% confidence intervals-95% CI=1.70-15.27, OR=2.61 95% CI=1.54-4.41, and OR=4.16 95% CI=1.45-11.91, respectively).


CONCLUSIONS
The results of the present study are in line with other authors' findings showing that smoking and alcohol consumption are the main risk factors for oropharyngeal cancer. The effect of occupational exposure to wood dust warrants further investigation.
Vlajinac
Hristina D
HD
Institute of Epidemiology, School of Medicine, Belgrade University, Visegradska 26, 11000 Belgrade, Serbia and Montenegro. sandragru@ptt.yu
Marinkovic
Jelena M
JM
Sipetic
Sandra B
SB
Andrejic
Dragoslava M
DM
Adanja
Benko J
BJ
Stosic-Divjak
Svetlana L
SL
D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D000428:Alcohol Drinking / Q000009:adverse effects*; D002274:Carcinogens, Environmental / Q000009:adverse effects; D016022:Case-Control Studies; D004391:Dust; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014934:Wood; D015022:Yugoslavia / Q000453:epidemiology
D000395:Air Pollutants, Occupational; D002274:Carcinogens, Environmental; D004391:Dust