title: Enzymatic biosensors.
abstract: The biosensor field has grown enormously since the first demonstration of the biosensor concept by Leland C. Clark, Jr. in 1962. Today's biosensor market is dominated by glucose biosensors, mass-produced enzyme electrodes for the rapid self-diagnosis of blood glucose levels by diabetes sufferers. Here we take a historical look at the inception, growth, and development of the enzyme biosensor field from a commercial viewpoint. The current status of the technology is evaluated and future trends in this dynamic and fast-moving field are also anticipated.
authors.affiliation: Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, United Kingdom. j.d.newman@cranfield.ac.uk
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Newman
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Setford
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods; D019295:Computational Biology / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D023281:Genomics / Q000295:instrumentation / Q000379:methods; D006801:Humans; D040901:Proteomics / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results
chemical_list: D004800:Enzymes, Immobilized