title: [Influence of neuromuscular blockade on the airway leak pressure of the ProSeal laryngeal mask airway].
abstract: BACKGROUND
  The ProSeal laryngeal mask airway (PLMA) is increasingly used for surgical procedures that might require the intraoperative use of neuromuscular blocking agents. The airway seal of the PLMA depends on the interplay of the surrounding soft tissue of the neck and the cuff of the mask. An intraoperative neuromuscular blockade could lead to a decrease of the airway leak pressure (P (leak)) secondary to the relaxation of the muscles of the neck. With this study we tested the hypothesis that a neuromuscular blockade can result in a decreased P (leak) of the PLMA.
  
  
  METHODS
  The P (leak) of the PLMA was studied in 73 female patients under total intravenous anaesthesia with propofol (0.1 - 0.15 mg kg (-1) min (-1)) and remifentanil (0.1 - 0.3 microg kg (-1) min (-1)) before and after a complete neuromuscular blockade produced by intravenous injection of 0.6 mg kg (-1) Rocuronium.
  
  
  RESULTS
  The P (leak) decreased by more than 10 % of the baseline P (leak) in 8 out of 73 patients (11 %); however, in the entire study population there was no significant difference between the mean baseline P (leak) (28.5 +/- 7.3 cm H(2)O) and the mean P (leak) after complete neuromuscular blockade (29.1 +/- 7.0 cm H(2)O); (p = 0.128).
  
  
  CONCLUSIONS
  No general correlation between application of a neuromuscular blocking agent and a decrease of the mean P (leak) was found. However, the decrease of the P (leak) by more than 10 % in 11 % of the patients shows that in certain patients the application of neuromuscular blocking agents can result in a decreased P (leak) of the PLMA and indicates the necessity to control the P (leak) of the PLMA under complete muscle paralysis preoperatively when neuromuscular blocking agents are used.
authors.affiliation: Klinik für Anästhesie und Intensivtherapie, Philipps Universität Marburg. Kaigoldmann1@aol.com
authors.forename: K
authors.initials: K
authors.lastname: Goldmann
authors.forename: N
authors.initials: N
authors.lastname: Hoch
authors.forename: H
authors.initials: H
authors.lastname: Wulf
mesh_terms: D000328:Adult; D000368:Aged; D000399:Air Pressure; D000732:Androstanols; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D005260:Female; D006801:Humans; D017214:Laryngeal Masks; D008875:Middle Aged; D009126:Muscle Relaxation / Q000502:physiology; D009334:Neck Muscles / Q000502:physiology; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil; D000077123:Rocuronium
chemical_list: D000732:Androstanols; D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D010880:Piperidines; D000077208:Remifentanil; D000077123:Rocuronium; D015742:Propofol