Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis.
OBJECTIVE
To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis (CRS) for response to endoscopic sinus surgery (ESS).


METHODS
Symptomatology was rated in 100 patients prior to as well as 12 and 24 months after surgery. Specimens taken during the procedure were examined and scored for goblet cells, subepithelial thickening, mast cells, and eosinophils. Multiple regression analysis was performed to predict the total score of subjective symptoms before treatment by histopathologic parameters. The correlation between histopathologic parameters and postoperative symptoms was then evaluated.


RESULTS
Goblet cells were the best predictor correlating with 5 symptoms. Subepithelial thickening correlated with 4 symptoms. Mast cell infiltration correlated with 3 symptoms. Eosinophilic infiltration correlated with only one symptom (P<0.05).


CONCLUSIONS
Certain histopathologic parameters in CRS are predictive of favorable response to ESS.


CONCLUSIONS
Pathologic evaluation may help the ENT surgeon to predict the persistence of certain CRS symptoms after ESS, even in patients at low risk for surgical failure.


METHODS
C-4.
Baudoin
Tomislav
T
Department of Otolaryngology-Head and Neck Surgery, Sestre Milosrdnice University Hospital, Zagreb, Croatia. tomislav.baudoin@zg.htnet.hr
Cupić
Hrvoje
H
Geber
Goran
G
Vagić
Davor
D
Grgić
Marko
M
Kalogjera
Livije
L
D000328:Adult; D001706:Biopsy; D002452:Cell Count; D004724:Endoscopy; D004804:Eosinophils / Q000473:pathology; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000473:pathology; D009297:Nasal Mucosa / Q000473:pathology*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications / Q000473:pathology* / Q000601:surgery