title: [New method for detection of nonpalpable breast cancer].
abstract: OBJECTIVE
  The objective of the study was to evaluate the feasibility of radio guided occult lesion localization (ROLL) in the cases of nonpalpable breast cancers with sentinel lymph node biopsy.
  
  
  METHODS
  Prospective clinical study
  
  
  METHODS
  Department of Gynecology and Obstetrics, 2nd Medical Faculty and Teaching Hospital, Praha
  
  
  METHODS
  Thirty-eight patients with nonpalpable breast cancer diagnosed by core cut biopsy underwent an injection of the radiopharmaceutical 18-20 hours before surgery. The dose of the radiopharmaceutical was 45 MBg into tumor and 15 MBg subdermaly. Surgical excision of radioactive breast tissue with nonpalpable tumor was carried out using the hand held gamma probe and the same technique was performed for biopsy of sentinel lymph node. Standard localization technique with hook-wire was performed in the control group of fifty-one patients.
  
  
  RESULTS
  Radioguided surgery of nonpalpable tumor was successful in all cases. Surgical margins were clear in all cases, in four cases (10.5%) the margins were only 2 mm. The sentinel node was identified in all cases, in 3 patients (7.9%) the sentinel node was involved by tumor and axillary lymphadenectomy was performed. Infiltrating carcinomas were diagnosed in the "hook-wire" group in 21 cases (41.2%), all with clear margins over 3mm. Proportion of margins status between ROLL and hook-wire was the same. It seems that the health tissue loss around the tumor is in hook-wire technique bigger but it requires next study.
  
  
  CONCLUSIONS
  Simultaneous performance of ROLL and sentinel node biopsy is useful and practicable methods in the management of nonpalpable breast cancer. In comparison to hook-wire, radioguided removal allows reduced excision volume and better lesion centering within the specimen.
authors.affiliation: 2. lékaiská fakulta Univerzity Karlovy a Fakultní nemocnice Motol, Praha.
authors.forename: P
authors.initials: P
authors.lastname: Strnad
authors.forename: L
authors.initials: L
authors.lastname: Rob
authors.forename: J
authors.initials: J
authors.lastname: Chod
authors.forename: M
authors.initials: M
authors.lastname: Halaska
authors.forename: H
authors.initials: H
authors.lastname: Krízová
authors.forename: A
authors.initials: A
authors.lastname: Zuntová
authors.forename: Z
authors.initials: Z
authors.lastname: Moravcová
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D011868:Radioisotopes; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy
chemical_list: D011868:Radioisotopes