title: Delayed puberty due to pituitary stalk dysgenesis and ectopic neurohypophysis.
abstract: Hypopituitarism is not a common cause of delayed puberty. A 22 year old man was referred to our clinic because of the absence of the development of secondary sexual characteristics. The patient had no complaints of physical discomfort. Random serum testosterone and luteinizing hormone level were obtained and found to be low. The combined pituitary function stimulation test revealed a partial hypopituitarism. A pituitary magnetic resonance imaging (MRI) was obtained and showed decreased pituitary stalk enhancement and ectopic neurohypophysis. Therefore, we conclude that the delayed puberty was a result of hypopituitarism due to pituitary stalk dysgenesis and ectopic neurohypophysis. The patient was started on hormone replacement therapy and gradually developed secondary sexual characteristics.
authors.affiliation: Departments of Internal Medicine, Diagnostic Radiology Korea University College of Medicine, Seoul, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Kyung Mook
authors.initials: KM
authors.lastname: Choi
authors.forename: Ohk Hyun
authors.initials: OH
authors.lastname: Ryu
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Suh
authors.forename: Nan Hee
authors.initials: NH
authors.lastname: Kim
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Dong Seop
authors.initials: DS
authors.lastname: Choi
mesh_terms: D000328:Adult; D020249:Hormone Replacement Therapy; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D010904:Pituitary Gland, Posterior / Q000002:abnormalities*; D011628:Puberty, Delayed / Q000209:etiology*; D013997:Time Factors