title: Magnetic resonance imaging of thickened pituitary stalk proceeding to Langerhans cell histiocytosis in a child.
abstract: Magnetic resonance imaging has shown isolated pituitary stalk thickening in certain cases of idiopathic or secondary central diabetes insipidus (DI) due to infiltrative processes. We present a 4-year-old boy who was initially diagnosed as having central DI. The MRI showed isolated pituitary stalk thickening with prominent homogeneous contrast enhancement. The remaining findings on MRI were within normal limits. The patient's personal and family history and laboratory and clinical findings were unremarkable; therefore, he was initially diagnosed as having idiopathic DI. Since central DI and isolated pituitary stalk thickening may be considered to be the first manifestations of Langerhans cell histiocytosis, we decided to follow up the patient. After 5 months, following the initial diagnosis, on skeletal X-ray survey, the patient did indeed develop multiple lytic skull lesions which, on biopsy, were histologically typical bone lesions of Langerhans cell histiocytosis.
authors.affiliation: Department of Radiology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey. halefoglu@hotmail.com
authors.forename: A M
authors.initials: AM
authors.lastname: Halefoglu
mesh_terms: D001706:Biopsy / Q000379:methods; D001921:Brain / Q000000981:diagnostic imaging; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage; D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010902:Pituitary Gland / Q000473:pathology*; D011859:Radiography
chemical_list: D003287:Contrast Media