[Effect of intramural and subserous myomas on in vitro fertilization cycles and their perinatal results].
OBJECTIVE
To evaluate the effect of intramural and subserous myomas in in vitro fertilization cycles, as well as its perinatal results.


METHODS
Cases and controls.


METHODS
All the IVF cycles between October 1999 and December 2004 were included. The variables of size and type of myomas, as well as variables of IVF cycles, implantation and pregnancy rates, and perinatal results were analyzed. We calculated the chi-square test to analyze the relationship between myomas and pregnancy. The t-Student test was used to establish the difference in the average between both groups regarding the studied variables. In the logistic regression analysis we controlled confusing variables.


RESULTS
We analyzed 431 cycles made in 364 patients divided into two groups: study cases (with myomas-65 cycles) and control cases (without myomas-366 cycles). Age was two years older in the study group (35.7 vs 33.5, p < 0.001). There was no difference in: duration, type of infertility, days of stimulation, gonadotrophin dose, total and mature follicles, and fertilization and implantation rates. We only observed a difference in the recovered oocytes (8.0 vs 9.7, p = 0.027). The pregnancy, abortion and live-born children rates were of 20.0 vs 23.2, 46.1 vs 29.4, and 46.1 vs 58.8%, respectively (study and control groups; p > 0.05). Logistic regression showed that myomas do not affect the possibility of getting pregnant.


CONCLUSIONS
Intramural and subserous myomas < 5 cm do not seem to have an effect in the IVF cycles nor in its perinatal results. In women with myomas < 5 cm that no dot distortion the uterine cavity it is questionable the usefulness of a myomectomy prior to IVF cycles.
Ballesteros Manzo
Alberto
A
Departamento de Reproducción Asistida, Instituto Nacional de Perinatología, Lomas Virreyes, México, DF.
Barros Delgadillo
Juan Carlos
JC
Ochoa Rueda
Senia
S
Villalobos Acosta
Sergio
S
Barroso Villa
Gerardo
G
Sánchez Solís
Victor
V
Gaviño Gaviño
Fernando
F
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007889:Leiomyoma / Q000473:pathology*; D009214:Myoma; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D014594:Uterine Neoplasms / Q000473:pathology*