A case of pulmonary cryptococcosis by capsule-deficient Cryptococcus neoformans.
Pulmonary infection by capsule-deficient Cryptococcus neoformans (CDCN) is a very rare form of pneumonia and it is seldom seen in the immunocompetent host. The authors experienced a case of pulmonary cryptococcosis by CDCN in 25-year-old woman who was without any significant underlying disease. The diagnosis was made from the percutaneous lung biopsy and special tissue staining, including Fontana-Masson silver (FMS) staining. Fungal culture confirmed the diagnosis afterward. Her clinical and radiologic features improved under treatment with fluconazol. It's known that CDCN is not so readily confirmed because fungal culture does not always result in growth of the organism and the empirical fungal stain is not helpful for the differentiation between CDCN and the other infections that are caused by the nonencapsulated yeast-like organisms. In this report, we emphasize the diagnostic value of performing FMS staining for differentiating a CDCN infection from the other confusing nonencapsulated yeast-like organisms.
Cheon
Won Seok
WS
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Eom
Kwang-Seok
KS
Yoo
Byoung Kwan
BK
Jang
Seung Hun
SH
Bahn
Joon-Woo
JW
Kim
Dong-Gyu
DG
Jung
Ki-Suck
KS
D000328:Adult; D002637:Chest Pain; D003371:Cough; D003453:Cryptococcosis / Q000175:diagnosis* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000382:microbiology*; D012835:Silver Nitrate
C051037:Fontana-Masson stain; D012835:Silver Nitrate