Neuroactive steroids prevent peripheral myelin alterations induced by diabetes.
The effect of the neuroactive steroids progesterone, dihydroprogesterone and tetrahydroprogesterone on myelin abnormalities induced by diabetes was studied in the sciatic nerve of adult male rats treated with streptozotocin. Streptozotocin increased blood glucose levels and decreased body weight gain, parameters not affected by steroids. Streptozotocin increased the number of fibers with myelin infoldings in the axoplasm, 8 months after the treatment. Chronic treatment for 1 month with progesterone and dihydroprogesterone resulted in a significant reduction in the number of fibers with myelin infoldings to control levels. Treatment with tetrahydroprogesterone did not significantly affect this myelin alteration. These results suggest that neuroactive steroids such as progesterone and dihydroprogesterone may represent therapeutic alternatives to counteract peripheral myelin alterations induced by diabetes.
Veiga
Sergio
S
Instituto Cajal, C.S.I.C., Avenida Dr. Arce 37, 28002 Madrid, Spain.
Leonelli
Emanuela
E
Beelke
Manolo
M
Garcia-Segura
Luis M
LM
Melcangi
Roberto C
RC
D004092:20-alpha-Dihydroprogesterone / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D008297:Male; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009186:Myelin Sheath / Q000378:metabolism* / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone