A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis.
We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.
Takeuchi
Hiroya
H
Department of Surgery, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, 152-8902, Japan. hiroyatakeuchi@aol.com
Futamata
Ken
K
Maeshima
Arafumi
A
Hirose
Shigemichi
S
Shimada
Atsushi
A
Kawaguchi
Yoshiki
Y
Tokuyama
Jo
J
Osumi
Koji
K
Kishi
Shinya
S
Hojo
Takashi
T
Kim
Shiei
S
Wada
Norihito
N
Oishi
Takashi
T
Isobe
Yoh
Y
Ikeuchi
Shunji
S
Kubochi
Kiyoshi
K
Matsumoto
Sumio
S
D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery