Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles.
Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
Cai
Chunming
C
Singh
Sandeep K
SK
D000578:Amidines / Q000138:chemical synthesis*; D008872:Microwaves; D014230:Triazoles / Q000737:chemistry*
D000578:Amidines; D014230:Triazoles