title: Some compaction characteristics of the hot water leaf extract og Nauclea latifiola: a potential antimalarial agent.
abstract: This study aims to develop a suitable tablet dosage form of Nauclea latifolia, a potential antimalarial agent. The compaction characteristics of the oven dried water extract were studied using the Heckel equation. The mechanical properties of the compacts were also determined. This preliminary information will be useful in developing a suitable dosage form of the extract for use in the management of malaria. The results showed that N. latifolia extract exhibited high densification due to dye filling while the subsequent rearrangement of the granules did not contribute, significantly, to their densification. The granules had enhanced plasticity as shown by the low yield point, Py. The tablets produced from the extract had good mechanical properties, with hardness increasing via compression pressure while the friability decreased. However, the tablets had poor disintegration properties; it is concluded that while tablets of suitable physical properties can be produced from the extract, a disintegrant would need to be included in the formulation to ensure adequate drug release.
authors.affiliation: Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD) Abuja, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Emeje
authors.forename: C Y
authors.initials: CY
authors.lastname: Isimi
authors.forename: D A N
authors.initials: DA
authors.lastname: Oqua
authors.forename: O O
authors.initials: OO
authors.lastname: Kunle
mesh_terms: D000962:Antimalarials / Q000737:chemistry*; D004339:Drug Compounding; D006358:Hot Temperature; D006801:Humans; D008517:Phytotherapy; D018515:Plant Leaves; D019666:Rubiaceae; D013678:Technology, Pharmaceutical; D014867:Water
chemical_list: D000962:Antimalarials; D014867:Water