Pharmacogenetics: yeast lead the way.
In this issue of Chemistry & Biology, Perlstein et al. use genetically diverse strains of yeast to study the genetic basis of differences in cellular responses to small molecules. Their results suggest that drug responses are regulated by a limited number of loci, and that this system can identify clusters of functionally similar molecules.
Foss
Eric
E
Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA.
Bedalov
Antonio
A
D000818:Animals; D016000:Cluster Analysis; D004353:Drug Evaluation, Preclinical; D025141:Drug Resistance, Fungal; D005800:Genes, Fungal; D006801:Humans; D007111:Immunity, Cellular; D010597:Pharmacogenetics; D015003:Yeasts / Q000235:genetics* / Q000254:growth & development