title: Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
abstract: Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.
authors.forename: Cheng-Chi
authors.initials: CC
authors.lastname: Chen
authors.forename: Young-Ji
authors.initials: YJ
authors.lastname: Shiao
authors.forename: Ruei-Da
authors.initials: RD
authors.lastname: Lin
authors.forename: Yi-Yuan
authors.initials: YY
authors.lastname: Shao
authors.forename: Min-Nan
authors.initials: MN
authors.lastname: Lai
authors.forename: Chun-Ching
authors.initials: CC
authors.lastname: Lin
authors.forename: Lean-Teik
authors.initials: LT
authors.lastname: Ng
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D020072:Polyporales / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013624:Taiwan
chemical_list: D004224:Diterpenes; D018696:Neuroprotective Agents