GeneRecon--a coalescent based tool for fine-scale association mapping.
GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable.


BACKGROUND
The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon


BACKGROUND
mailund@birc.au.dk.
Mailund
Thomas
T
Bioinformatics Research Center, University of Aarhus Høegh-Guldbergs Gade 10, DK-8000 Arhus C, Denmark. mailund@birc.au.dk
Schierup
Mikkel H
MH
Pedersen
Christian N S
CN
Madsen
Jesper N
JN
Hein
Jotun
J
Schauser
Leif
L
D000465:Algorithms; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software