Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A.
Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia-II were evaluated for their antiviral activity against various viruses such as HIV HSV-1, HSV-2, and ECMV.
Hong
Joon Hee
JH
Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
Kim
So-Young
SY
Oh
Chang-Hyun
CH
Yoo
Kyung Ho
KH
Cho
Jung-Hyuck
JH
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans
D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine