title: The ligand/RAGE axis: lighting the fuse and igniting vascular stress.
abstract: Vascular inflammation contributes critically to the initiation and progression of atherosclerosis. These processes are accelerated in hyperglycemia and play key roles in the increased incidence and severity of myocardial infarction and stroke observed in diabetes. Evidence suggests that the ligands of the receptor for advanced glycation endproducts (RAGE), a multiligand member of the immunoglobulin superfamily, interact with this receptor to play important roles in both early development and progression of atherosclerosis and vascular inflammation. Studies in animal models of vascular injury underscored the potent impact of RAGE blockade; administration of ligand-binding decoys of RAGE or antibodies to the receptor reduced the consequences of diabetes, hyperlipidemia, and physical injury to the vessel wall. This review focuses on the ligand repertoire of RAGE, the impact of ligand-RAGE interaction, and the potent effect of RAGE blockade in rodent models of vascular injury.
authors.affiliation: Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P&S 17-501, New York, NY 10032, USA.
authors.forename: Shi Fang
authors.initials: SF
authors.lastname: Yan
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Naka
authors.forename: Barry I
authors.initials: BI
authors.lastname: Hudson
authors.forename: Kevan
authors.initials: K
authors.lastname: Herold
authors.forename: Shi Du
authors.initials: SD
authors.lastname: Yan
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramasamy
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D004195:Disease Models, Animal; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D006801:Humans; D007249:Inflammation; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D014652:Vascular Diseases / Q000473:pathology* / Q000628:therapy*
chemical_list: D016229:Amyloid beta-Peptides; D017127:Glycation End Products, Advanced; D008024:Ligands