title: Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain.
abstract: Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside.
authors.affiliation: Department of Paediatrics and Child Health, University College London, UK. topunaustin@doctors.org.uk
authors.forename: T
authors.initials: T
authors.lastname: Austin
authors.forename: A P
authors.initials: AP
authors.lastname: Gibson
authors.forename: G
authors.initials: G
authors.lastname: Branco
authors.forename: R Md
authors.initials: RM
authors.lastname: Yusof
authors.forename: S R
authors.initials: SR
authors.lastname: Arridge
authors.forename: J H
authors.initials: JH
authors.lastname: Meek
authors.forename: J S
authors.initials: JS
authors.lastname: Wyatt
authors.forename: D T
authors.initials: DT
authors.lastname: Delpy
authors.forename: J C
authors.initials: JC
authors.lastname: Hebden
mesh_terms: D001810:Blood Volume / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology*; D001927:Brain Diseases / Q000151:congenital; D002543:Cerebral Hemorrhage / Q000151:congenital / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn / Q000502:physiology*; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood*; D012016:Reference Values
chemical_list: D010100:Oxygen