Voltammetric studies of sparfloxacin and application to its determination in pharmaceuticals.
A detailed study of the electrochemistry of sparfloxacin at a glassy carbon electrode was carried out in the pH range 2.0-10.0 in aqueous solution using cyclic and differential pulse voltammetry. Influence of different supporting electrolytes, pH, scan rate and concentrations were studied on the voltammetric response. The studies revealed the irreversible oxidation of sparfloxacin at basic pH in a diffusion controlled manner. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations.
Girish Kumar
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K
Department of Applied Chemistry, Cochin University of Science and Technology, Kerala, India. giri@cusat.ac.in
Augustine
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P
Poduval
R
R
John
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S
D000995:Antitubercular Agents / Q000032:analysis*; D002138:Calibration; D004563:Electrochemistry; D004566:Electrodes; D024841:Fluoroquinolones / Q000032:analysis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D013607:Tablets
D000995:Antitubercular Agents; D024841:Fluoroquinolones; D007202:Indicators and Reagents; D013607:Tablets; C061363:sparfloxacin