title: [Drug safety of NSAIDs and COX-2 inhibitors].
abstract: In this review the risk-benefit ratio of COX-2 inhibitors and NSAIDs is compared. In the discussion of the safety of these two groups different evaluation standards are used, which is not a basis of a rational pharmacotherapy.
authors.affiliation: Institut für Pharmakologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel.
authors.forename: Thomas
authors.initials: T
authors.lastname: Herdegen
authors.forename: Joachim
authors.initials: J
authors.lastname: Fauler
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D010146:Pain / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors