title: Endemic pemphigus foliaceus in Venezuela: report of two children.
abstract: Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously associated with this disease. However, it shares a common epitope with all the human leukocyte antigen DRB1 alleles that have been involved in this disease among Brazilian populations. Although this condition is endemic in Brazil, our patients are the first two reported in Venezuela.
authors.affiliation: Department of Dermatology, Hospital Universitario de Caracas, Luis Razetti School of Medicine, Central University of Venezuela, Caracas, Venezuela.
authors.forename: Francisco
authors.initials: F
authors.lastname: González
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Sáenz
authors.forename: Antonietta
authors.initials: A
authors.lastname: Cirocco
authors.forename: Inés Maria
authors.initials: IM
authors.lastname: Tacaronte
authors.forename: Javier Enrique
authors.initials: JE
authors.lastname: Fajardo
authors.forename: Adriana
authors.initials: A
authors.lastname: Calebotta
mesh_terms: D000293:Adolescent; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014687:Venezuela
chemical_list: D002738:Chloroquine; D011241:Prednisone