Understanding structural brain changes in schizophrenia.
Schizophrenia is a chronic progressive disorder that has at its origin structural brain changes in both white and gray matter. It is likely that these changes begin prior to the onset of clinical symptoms in cortical regions, particularly those concerned with language processing. Later, they can be detected by progressive ventricular enlargement. Current magnetic resonance imaging (MRI) technology can provide a valuable tool for detecting early changes in cortical atrophy and anomalous language processing, which may be predictive of who will develop schizophrenia.
DeLisi
Lynn E
LE
New York University, The Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, NY 10962, USA. DeLisi76@aol.com
Szulc
Kamila U
KU
Bertisch
Hilary C
HC
Majcher
Magda
M
Brown
Kyle
K
D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*
D014150:Antipsychotic Agents