title: Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.
abstract: Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.
authors.affiliation: Department of Medicine, University of California-San Francisco, San Francisco General Hospital, Box 0811, San Francisco, CA 94143, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Dokomajilar
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Nsobya
authors.forename: Bryan
authors.initials: B
authors.lastname: Greenhouse
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Grant
authors.initials: G
authors.lastname: Dorsey
mesh_terms: D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D019353:Endemic Diseases; D004983:Ethanolamines; D005449:Fluorenes / Q000627:therapeutic use; D019450:Genes, MDR; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D011110:Polymorphism, Genetic; D015995:Prevalence; D012641:Selection, Genetic; D012717:Sesquiterpenes / Q000627:therapeutic use; D014454:Uganda / Q000453:epidemiology
chemical_list: D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D012717:Sesquiterpenes