Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.
Six new sesquiterpene glycosides, compounds 1-6, with eudesmanolide, elemanolide, lindenane, and germacranolide sesquiterpene aglycons, along with one known compound, chloranoside A (7), have been isolated from the whole plant of Sarcandra glabra. The structures of 1-6 were elucidated by chemical and spectroscopic methods including (1)H-(1)H COSY, HMQC, HMBC, and NOESY NMR experiments. In addition, compounds 1-7 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
Li
Yuan
Y
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Zhang
Dong-Ming
DM
Li
Jian-Bei
JB
Yu
Shi-Shan
SS
Li
Yan
Y
Luo
Yong-Ming
YM
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012717:Sesquiterpenes; D005688:Galactosamine