Correlation between optical coherence tomography and autofluorescence in acute posterior multifocal placoid pigment epitheliopathy.
OBJECTIVE
To report a case of bilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) evaluated by optical coherence tomography (OCT), fundus autofluorescence (AF) and microperimetry, both in the acute phase and after resolution of symptoms.


METHODS
Complete ophthalmological evaluation, including fluorescein angiography, OCT, AF, and microperimetry upon presentation and 1 month later, after lesions have subsided. An attempt to correlate the findings on presentation and changes after resolution is performed using the results of these new investigational techniques.


RESULTS
APMPPE showed hyperreflectance in OCT at the level of the outer retinal layers, without increase in retinal thickness. AF revealed early decreased fluorescence due to a masking effect, and later reveals increased fluorescence after resolution of OCT findings. Function is disturbed at the lesion sites, as shown by microperimetry, and later returns to near normal values on microperimetry.


CONCLUSIONS
APMPPE shows outer retinal layers changes on OCT, which resolve totally after subsidence of the acute phase. AF shows areas of increased fluorescence after resolution, with near normal return of function on microperimetry.
Souka
Ahmed A R
AA
Ophthalmology Department, University of Regensburg, Regensburg, Germany.
Hillenkamp
Jost
J
Gora
Felix
F
Gabel
Veit-Peter
VP
Framme
Carsten
C
D000208:Acute Disease; D000293:Adolescent; D005260:Female; D005451:Fluorescein Angiography; D005453:Fluorescence; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity; D058609:Visual Field Tests