Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.
Dokomajilar
Christian
C
Department of Medicine, University of California-San Francisco, San Francisco General Hospital, Box 0811, San Francisco, CA 94143, USA.
Nsobya
Samuel L
SL
Greenhouse
Bryan
B
Rosenthal
Philip J
PJ
Dorsey
Grant
G
D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D019353:Endemic Diseases; D004983:Ethanolamines; D005449:Fluorenes / Q000627:therapeutic use; D019450:Genes, MDR; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D011110:Polymorphism, Genetic; D015995:Prevalence; D012641:Selection, Genetic; D012717:Sesquiterpenes / Q000627:therapeutic use; D014454:Uganda / Q000453:epidemiology
D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D012717:Sesquiterpenes