title: Specific phobia: a disorder of fear conditioning and extinction.
abstract: Specific phobia is the most prevalent of the anxiety disorders. Although there have been relatively few studies of its psychobiology and pharmacotherapy, there is a rich laboratory of literature on fear conditioning and extinction and a clear evolutionary perspective. Advances in the cognitive-affective neuroscience of fear processing may ultimately lead to new approaches to the clinical management of phobias.
authors.affiliation: Department of Psychiatry, University of Cape Town, Cape Town, South Africa.
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.forename: Hisato
authors.initials: H
authors.lastname: Matsunaga
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D005075:Biological Evolution; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003214:Conditioning, Classical / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D010698:Phobic Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors