title: Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.
abstract: Tumor cells transduced with herpes simplex virus thymidine kinase gene has been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facial preparation of 5-[125I]iodoarabinosyl uridine starting from commercial available uridine is reported herein. Interestingly, the tin group in 5-trimethylstannyl arabinosyluridine was easily removed during purification. The destannylation through the formation of a six-ligand coordination involving 2'-hydroxyl and tin was thereby proposed.
authors.affiliation: Department of Nuclear Science, National Tsing-Hua University, Hsinchu 300, Taiwan. csyu@mx.nthu.edu.tw
authors.forename: Chung-Shan
authors.initials: CS
authors.lastname: Yu
authors.forename: Li-Wu
authors.initials: LW
authors.lastname: Chiang
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Wu
authors.forename: Ren-Tsong
authors.initials: RT
authors.lastname: Wang
authors.forename: Shao-Wei
authors.initials: SW
authors.lastname: Chen
authors.forename: Heng-Yen
authors.initials: HY
authors.lastname: Wang
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Yeh
mesh_terms: D001086:Arabinofuranosyluracil / Q000138:chemical synthesis*; D002614:Chelating Agents; D005814:Genes, Viral; D006801:Humans; D007457:Iodine Radioisotopes; D018139:Simplexvirus / Q000201:enzymology*; D013937:Thymidine Kinase / Q000235:genetics*
chemical_list: D002614:Chelating Agents; D007457:Iodine Radioisotopes; D001086:Arabinofuranosyluracil; D013937:Thymidine Kinase