title: Two-step selection of mRNAs in initiation of protein synthesis.
abstract: In a recent issue of Molecular Cell, Studer and Joseph (2006) clarified the molecular basis of the "standby model" and demonstrated how two-step binding of mRNAs to the small ribosomal subunit depends on initiator tRNA and initiation factors, with far-reaching implications for posttranscriptional regulation of gene expression.
authors.affiliation: Department of Cell and Molecular Biology, Uppsala Universitet, BMC, S-75124 Uppsala, Sweden.
authors.forename: Vasili
authors.initials: V
authors.lastname: Hauryliuk
authors.forename: Mans
authors.initials: M
authors.lastname: Ehrenberg
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D005786:Gene Expression Regulation; D007700:Kinetics; D009690:Nucleic Acid Conformation; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012335:RNA, Ribosomal