Individual differences in the functional neuroanatomy of inhibitory control.
We combined the data of five event-related fMRI studies of response inhibition. The re-analysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18-46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absent minded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network.
Garavan
Hugh
H
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Hugh.Garavan@tcd.ie <Hugh.Garavan@tcd.ie>
Hester
Robert
R
Murphy
Kevin
K
Fassbender
Catherine
C
Kelly
Clare
C
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007206:Individuality; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D013997:Time Factors
D010100:Oxygen