title: Effect of valproic acid on withdrawal therapy in patients with overuse of chronic daily headache medications.
abstract: Discontinuation of medication is the treatment of choice for patients with chronic daily headache (CDH) who overuse their medications. This treatment may be difficult due to increased headache severity observed in patients immediately after withdrawal. We retrospectively evaluated the efficacy of valproic acid therapy in 66 patients with overuse of CDH medication during withdrawal therapy. Patients were all withdrawn from medications and valproic acid started at 250 mg or 500 mg daily. Forty-two (63.6%) patients had decreased headache severity, including 27.3% objective responses in the first week. At the last visit in the 12th week, 50 patients were headache-free and only one patient had persistent headache. Fifteen patients withdrew from therapy due to side effects and lost to follow-up within this timeframe. Thus, low dose valproic acid appears to be safe and effective in the management of withdrawal therapy.
authors.affiliation: Department of Neurology, Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey. oecoskun@hotmail.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Coskun
authors.forename: Serap
authors.initials: S
authors.lastname: Ucler
authors.forename: Leyla
authors.initials: L
authors.lastname: Cavdar
authors.forename: Levent E
authors.initials: LE
authors.lastname: Inan
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D018682:GABA Agents / Q000627:therapeutic use*; D020773:Headache Disorders / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D018682:GABA Agents; D014635:Valproic Acid