title: Optic pathway glioma: outcome and prognostic factors in a surgical series.
abstract: OBJECTIVE
  The goals of this study were to evaluate the surgical outcomes of optic pathway glioma (OPG) and to analyze the prognostic factors related to the progression-free survival.
  
  
  METHODS
  A retrospective review was conducted on 33 patients who underwent surgery for OPG; these included 15 male and 18 female patients with a mean age of 8.3 years. The mean duration of follow-up was 52 months.
  
  
  CONCLUSIONS
  The preservation rate of ipsilateral vision was 25%, while that of contralateral vision was 83% (P<0.001). There was no remarkable endocrine improvement after surgery. The overall and progression-free survival rates at 5 years were 93.6 and 52.4%, respectively. In our study, the predictors for tumor progression were children younger than 5 years of age (p=0.023) and of female gender (p=0.022). Because of the variable course of OPG, treatment policy should be optimized individually according to patient's status.
authors.affiliation: Department of Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ahn
authors.forename: Byung-Kyu
authors.initials: BK
authors.lastname: Cho
authors.forename: Seung-Ki
authors.initials: SK
authors.lastname: Kim
authors.forename: You-Nam
authors.initials: YN
authors.lastname: Chung
authors.forename: Chang Sub
authors.initials: CS
authors.lastname: Lee
authors.forename: Il Han
authors.initials: IH
authors.lastname: Kim
authors.forename: Sei Won
authors.initials: SW
authors.lastname: Yang
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Hyun Jib
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hee-Won
authors.initials: HW
authors.lastname: Jung
authors.forename: Kyu-Chang
authors.initials: KC
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D018572:Disease-Free Survival; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology / Q000601:surgery; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D009897:Optic Chiasm / Q000473:pathology / Q000601:surgery; D020339:Optic Nerve Glioma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate