title: Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats.
abstract: Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Seulki
authors.initials: S
authors.lastname: Lee
authors.forename: Sang Kyoon
authors.initials: SK
authors.lastname: Kim
authors.forename: Dong Yun
authors.initials: DY
authors.lastname: Lee
authors.forename: Su Young
authors.initials: SY
authors.lastname: Chae
authors.forename: Youngro
authors.initials: Y
authors.lastname: Byun
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D001682:Biological Availability; D001702:Biopharmaceutics; D002412:Cations; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D019946:Propylene Glycol / Q000737:chemistry; D051381:Rats; D012997:Solvents / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001647:Bile Acids and Salts; D002412:Cations; D012997:Solvents; D019946:Propylene Glycol; D002443:Ceftriaxone