Detection of activated, TIMP-free MMPs.
MMP inhibitor-tethered resins provide a method for detection of activated MMPs in tissues. These measurements will help to elucidate in situ mechanisms of MMP activation, further our understanding of the tumor microenvironment, and facilitate development of MMP-inhibitor therapy.
Zucker
Stanley
S
Department of Research and Medicine, VA Medical Center, Northport, New York 11768, USA.
Cao
Jian
J
D004789:Enzyme Activation; D006801:Humans; D020782:Matrix Metalloproteinases / Q000032:analysis* / Q000378:metabolism; D008954:Models, Biological; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases