Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors.
Using a dipeptide nitrile scaffold we have identified a potent and selective inhibitor of human dipeptidyl peptidase I.
Bondebjerg
Jon
J
Arpida A/S, Vesterbrogade 188, DK-1800 Frederiksberg C, Denmark. jbondebjerg@arpida.uk
Fuglsang
Henrik
H
Valeur
Kirsten Rosendal
KR
Pedersen
John
J
Naerum
Lars
L
D020789:Cathepsin C / Q000037:antagonists & inhibitors*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004151:Dipeptides; D004791:Enzyme Inhibitors; D009570:Nitriles; D020789:Cathepsin C