Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease.
The National Heart, Lung, and Blood Institute (NHLBI) convened a conference call working group, consisting of experts in stroke and cerebrovascular biology on January 28, 2005. The purpose of this working group was to develop a prioritized set of recommendations for NHLBI to establish a focused and comprehensive set of research activities in cerebrovascular biology and disease. Three thematic areas of research emerged: (1) molecular and cellular neurobiology of cerebral blood vessels, focusing on genomics and proteomics, neurovascular signaling and cerebrovascular embryogenesis, development and plasticity; (2) resource development, involving the development of new methodological approaches for normal and altered function of the neurovascular unit, collaborative research, and training in cerebrovascular pathobiology; and (3) cerebrovascular diseases and translational approaches, addressing vascular mechanisms of disease, the role of risk factors, importance of biomarkers with the ultimate goal of developing new treatments.
Iadecola
Costantino
C
Weill Cornell Medical College, New York, NY, USA.
Goldman
Stephen S
SS
Harder
David R
DR
Heistad
Donald D
DD
Katusic
Zvonimir S
ZS
Moskowitz
Michael A
MA
Simard
J Marc
JM
Sloan
Michael A
MA
Traystman
Richard J
RJ
Velletri
Paul A
PA
D000818:Animals; D035843:Biomedical Research; D001808:Blood Vessels / Q000196:embryology / Q000254:growth & development; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D004195:Disease Models, Animal; D023281:Genomics; D006801:Humans; D040901:Proteomics; D015398:Signal Transduction