title: Oral malignant melanoma associated with pseudoepitheliomatous hyperplasia. Report of a case.
abstract: BACKGROUND
  Pseudoepitheliomatous hyperplasia (PEH), a histological mimic of squamous cell carcinoma, is an exuberant reactive epithelial proliferation that may be induced by a variety of infectious, traumatic, inflammatory and neoplastic conditions of the skin and mucous membranes. PEH has been described in association with Spitz nevi and intramucosal nevi but not with oral malignant melanoma.
  
  
  RESULTS
  A case of PEH in malignant melanoma of the palate in a 46-year-old female patient has been described. A search of the English literature did not disclose any previously reported case of such event.
  
  
  CONCLUSIONS
  PEH associated with oral malignant melanoma is apparently very rare and most likely originates from the surface epithelium. This is in contrast with PEH in cutaneous melanoma where follicular or eccrine units have been suggested to be the origin.
authors.affiliation: Unit of Oral Pathology and Medicine, Section of Odontostomatology, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Meleti
authors.forename: Wolter J
authors.initials: WJ
authors.lastname: Mooi
authors.forename: Isaäc
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology*; D005260:Female; D005881:Gingiva / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology*; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D010159:Palate / Q000473:pathology