title: TN/TN glottic carcinoma: a comparison of two fractionation schedules.
abstract: The aim of this paper is the retrospective comparison of accelerated/hypofractionated radiotherapy regimen (AHFX) with standard fractionation regimen (SFX) for patients with early glottic carcinoma. One hundred and forty-five patients with T(1)-T(2) glottic cancer between 1986 and 1998 were eligible. Before 1992, patients received 60-66 Gy in 30-33 fractions over 6-6.5 weeks (SFX) with (60)Co and 6-MV beams. After 1992, patients received 52.5-55 Gy in 20 fractions over 4 weeks (AHFX) using 6-MV beams. The end-points were overall survival, laryngectomy-free survival (LFS), loco-regional control and toxicity. One hundred and two were stage T(1)N(0); 43 were stage T(2)N(0). Median follow up was 4.9 years. The 5-year overall survival was 78%. Five-year loco-regional control in T(1)N(0) patients was higher in AHFX than in SFX group (95 vs 75%, P = 0.002). Loco-regional control in T(2)N(0) patients was similar for AHFX and SFX (81 vs 80%, P = 0.813). Overall LFS was 88%. T(1)N(0) AHFX patients had 5-year LFS of 95% compared with 75% for SFX (P = 0.003). For T(2)N(0) AHFX patients, overall LFS was 92% compared with 80% for the SFX group (P = 0.291). No grade 4 or 5 late toxicity occurred. One AHFX patient developed grade 3 toxicity; two of 51 SFX patients developed grade 2 toxicity versus five of 94 AHFX patients. AHFX using 6-MV beams for treatment of early glottic cancer resulted in equivalent LFS and toxicity when compared with SFX.
authors.affiliation: Department of Radiation Oncology, Auckland District Health Board, Auckland, New Zealand. susan.short@xtra.co.nz
authors.forename: S
authors.initials: S
authors.lastname: Short
authors.forename: H
authors.initials: H
authors.lastname: Krawitz
authors.forename: A
authors.initials: A
authors.lastname: Macann
authors.forename: T
authors.initials: T
authors.lastname: West
authors.forename: R P
authors.initials: RP
authors.lastname: Morton
authors.forename: N P
authors.initials: NP
authors.lastname: McIvor
authors.forename: J
authors.initials: J
authors.lastname: Chaplin
authors.forename: P
authors.initials: P
authors.lastname: Simcock
authors.forename: J
authors.initials: J
authors.lastname: Gathercole
authors.forename: B
authors.initials: B
authors.lastname: Dorman
authors.forename: A
authors.initials: A
authors.lastname: Hindley
mesh_terms: D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005931:Glottis / Q000473:pathology* / Q000528:radiation effects* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome