title: End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation.
abstract: We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.
authors.affiliation: Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Apetauerova
authors.forename: R Kevin
authors.initials: RK
authors.lastname: Ryan
authors.forename: Susie I
authors.initials: SI
authors.lastname: Ro
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Arle
authors.forename: Jay
authors.initials: J
authors.lastname: Shils
authors.forename: Efstathios
authors.initials: E
authors.lastname: Papavassiliou
authors.forename: Daniel
authors.initials: D
authors.lastname: Tarsy
mesh_terms: D046690:Deep Brain Stimulation; D020820:Dyskinesias / Q000209:etiology* / Q000628:therapy*; D005260:Female; D007839:Functional Laterality; D005917:Globus Pallidus; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D020531:Subthalamic Nucleus