title: [The multifaceted effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in organisms, especially dentition changes].
abstract: Dioxins are by products of various technological processes in many branches of industry and products of the combustion of chlorine compounds at low temperatures. They include polychlorated dibenzo-p-dioxins and dibenzofurans. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most dangerous to the human organism and is a model substance to define the toxicity of particular dioxins in mixture. TCDD in small doses exerts a toxic influence on embryos and maturing persons. Dioxin exposure to animals and people causes changes in the immunological system, fetus failure, and defects in fertility and in internal organs and is carcinogenic. Knowledge in this area is rather well documented and has expanded. However, there is little information about dioxin's influence on dentition development. In this review, recent literature reports and the results of own investigations of the general biological effects of dioxins, especially for dentition, are presented.
authors.affiliation: Zakład Fizjologii AM we Wrocławiu. i.calkosinski@wp.pl
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Całkosiński
authors.forename: Maciej
authors.initials: M
authors.lastname: Dobrzyński
authors.forename: Marek
authors.initials: M
authors.lastname: Cegielski
authors.forename: Anna
authors.initials: A
authors.lastname: Sieja
authors.forename: Monika
authors.initials: M
authors.lastname: Całkosińska
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003817:Dentition; D004195:Disease Models, Animal; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007223:Infant; D009805:Odontogenesis / Q000187:drug effects*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*; D014070:Tooth / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D004785:Environmental Pollutants; D006728:Hormones; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens