Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease.
Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and in an animal model of Parkinson's disease based on increased polysialic acid-like immunoreactivity. Changes in neurogenesis often appear parallel to changes in angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-1). Using immunohistochemistry, we identified in this study upregulation of VEGF in the substantia nigra but not in the striatum of patients with Parkinson's disease by enzyme-linked immunosorbent assay. Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease.
Wada
Keiichirou
K
Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Arai
Hiroyuki
H
Takanashi
Masashi
M
Fukae
Jiro
J
Oizumi
Hideki
H
Yasuda
Toru
T
Mizuno
Yoshikuni
Y
Mochizuki
Hideki
H
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D003952:Diagnostic Imaging / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000145:classification / Q000378:metabolism*; D018709:Statistics, Nonparametric; D042461:Vascular Endothelial Growth Factor A / Q000145:classification / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor