The pathogenesis of immune thrombocytopaenic purpura.
Immune thrombocytopaenic purpura (ITP) is an autoimmune bleeding disease that is rarely fatal. However, in many adults treatment is unsatisfactory, with as much morbidity from the immunosuppressive effects of treatment as from bleeding. Identifying the underlying disease process should help us to identify more targeted therapies and improve not only the treatment but also the quality of life of patients with this disorder.
Cooper
Nichola
N
Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA.
Bussel
James
J
D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity; D001792:Blood Platelets / Q000276:immunology; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D007108:Immune Tolerance; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology