A new steroidal saponin from Agave shrevei.
A new steroidal saponin was isolated from the leaves of Agave shrevei. Its structure was established as 3-[O-beta-D-glucopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)-O-[O-beta-D-glucopyranosyl-(1-->6)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranosyl)-oxy]-(3beta,5alpha,25R)-spirostane. The structural identification was performed using detailed analyses of 1H- and 13C-NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR, HMBC, and HMQC) and chemical conversions. The haemolytic activity of the steroidal saponin was evaluated using an in vitro assay.
Pereira Da Silva
Bernadete
B
Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21944-971, Rio de Janeiro, Brazil.
Valente
Ana Paula
AP
Paz Parente
José
J
D027882:Agave / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
C512673:3-(O-beta-D-glucopyranosyl-(1-2)-O-(O-beta-D-glucopyranosyl-(1-4)-O-(O-beta-D-glucopyranosyl-(1-6))-O-beta-D-glucopyranosyl-(1-4)-beta-D-galactopyranosyl)-oxy)-(3beta,5alpha,25R)-spirostane; D012503:Saponins; D013150:Spirostans