Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470.
Potential inhibitory effects of the antiangiogenic drug TNP-470 on rat urinary bladder carcinogenesis were investigated in F344 male rats initiated with 0.05% BBN in the drinking water for 8 weeks. Group 1 was then continuously treated with TNP-470 by subcutaneous injection using osmotic minipump until the end of the experiment; group 2 served as the control with only initiation. The incidences and multiplicities of papillomas and carcinomas in the TNP-470-treated group were significantly decreased compared to the control group values along with the tumor vascular density. In conclusion, TNP-470 can inhibit rat urinary bladder carcinogenesis, presumably through its effects on angiogenesis.
Wanibuchi
Hideki
H
Department of Pathology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan. wani@med.osaka-cu.ac.jp
Wei
Min
M
Salim
Elsayed I
EI
Kinoshita
Anna
A
Morimura
Keiichirou
K
Sudo
Katsuichi
K
Fukushima
Shoji
S
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D001707:Biopsy, Needle; D015152:Blotting, Northern; D002085:Butylhydroxybutylnitrosamine; D016009:Chi-Square Distribution; D003510:Cyclohexanes; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007150:Immunohistochemistry; D008297:Male; D009374:Neoplasms, Experimental; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D011336:Probability; D012333:RNA, Messenger / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D012680:Sensitivity and Specificity; D012717:Sesquiterpenes / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D020533:Angiogenesis Inhibitors; D003510:Cyclohexanes; D012333:RNA, Messenger; D012717:Sesquiterpenes; D042461:Vascular Endothelial Growth Factor A; D002085:Butylhydroxybutylnitrosamine; D000077609:O-(Chloroacetylcarbamoyl)fumagillol