title: Revisiting the role of neutralizing antibodies in mother-to-child transmission of HIV-1.
abstract: We analyzed the association between mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) and maternal neutralizing antibodies to heterologous primary isolates of various HIV-1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing activity. Our study sample included 90 Thai women for whom the timing of HIV-1 transmission (in utero or intrapartum) was known. The statistical analysis included a conditional logistic-regression model to control for both plasma viral load and duration of zidovudine prophylaxis. The higher the titer of neutralizing antibodies to a heterologous strain of the same clade, the lower the rate of MTCT of HIV-1. More specifically, high levels of neutralizing antibodies to the MBA (CRF01_AE) strain were associated with low intrapartum transmission of HIV-1. This suggested that such heterologous neutralizing antibodies may be involved in the natural prevention of late perinatal HIV transmission. These data are consistent with the hypothesis that the use of some antibodies might help to prevent perinatal HIV transmission, through passive immunoprophylaxis. Moreover, the study of humoral factors associated with MTCT of HIV-1 may identify correlates of protection that should help in the design of efficient HIV/acquired immunodeficiency syndrome vaccines.
authors.affiliation: Universite Francois Rabelais, Equipe Associee 3856, Centre National de Reference du VIH, Tours, France. fbarin@med.univ-tours.fr
authors.forename: Francis
authors.initials: F
authors.lastname: Barin
authors.forename: Gonzague
authors.initials: G
authors.lastname: Jourdain
authors.forename: Sylvie
authors.initials: S
authors.lastname: Brunet
authors.forename: Nicole
authors.initials: N
authors.lastname: Ngo-Giang-Huong
authors.forename: Supawadee
authors.initials: S
authors.lastname: Weerawatgoompa
authors.forename: Warit
authors.initials: W
authors.lastname: Karnchanamayul
authors.forename: Surabhon
authors.initials: S
authors.lastname: Ariyadej
authors.forename: Rawiwan
authors.initials: R
authors.lastname: Hansudewechakul
authors.forename: Jullapong
authors.initials: J
authors.lastname: Achalapong
authors.forename: Prapap
authors.initials: P
authors.lastname: Yuthavisuthi
authors.forename: Chaiwat
authors.initials: C
authors.lastname: Ngampiyaskul
authors.forename: Sorakij
authors.initials: S
authors.lastname: Bhakeecheep
authors.forename: Chittaphon
authors.initials: C
authors.lastname: Hemwutthiphan
authors.forename: Marc
authors.initials: M
authors.lastname: Lallemant
mesh_terms: D018562:Disease Transmission, Infectious; D005260:Female; D015483:HIV Antibodies / Q000097:blood* / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D009035:Mothers; D009500:Neutralization Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D013223:Statistics as Topic
chemical_list: D015483:HIV Antibodies