title: Kidney transplantation using donors with history of diabetes and hypertension.
abstract: OBJECTIVE
  Due to the persistant organ shortage for kidney transplantation, donor selection has changed in the past years. Although hypertension and diabetes mellitus are known to be risk factors for renal insufficiency, kidneys from donors with these diagnoses in their history have been accepted for kidney transplantation even with an increased risk of poor graft function. Herein we have reported our experience with kidney transplantation using grafts from donors with both, a history of type II diabetes and hypertension.
  
  
  METHODS
  Between 2000 and 2005, ten patients were grafted using donors with history of type II diabetes mellitus and hypertension. Mean donor age was 58 +/- 7.5 years and recipient age, 52.2 +/- 15.7 years. Mean HLA mismatch was 0.8 (A); 1.2 (B) and 0.9 (DR). Cold ischemia time was 17.4 +/- 4.1 hours. Immunosuppression was based on CyA (n = 7), tacrolimus (n = 2) or sirolimus (n = 1).
  
  
  RESULTS
  Six patients (60%) showed good initial function, and four (40%) had delayed graft function (DGF). One patient died at ten weeks due to multiorgan failure. Two (20%) biopsy-proven rejections were diagnosed, one of which was resistant to therapy. Six months after kidney transplantation, 7 (77%, n = 9) showed good graft function (creatinine 1.3 to 2.4 mg/dL), but one patient displayed long-lasting DGF with poor function.
  
  
  CONCLUSIONS
  Grafts from donors with a history of diabetes mellitus and hypertension are suitable for kidney transplantation. Elevated rate of DGF (40%) would justify allocation of these organs to local transplant centers to shorten ischemia time and thereby reduce DGF and achieve better long-term results. Identification and detailed evaluation of these donors prior to allocation (eg, HbAlc, biopsy) may help transplant centers to accept these kidneys.
authors.affiliation: Department of General Surgery, University of Münster, Münster, Germany. wolterh@uni-muenster.de
authors.forename: H H
authors.initials: HH
authors.lastname: Wolters
authors.forename: J G
authors.initials: JG
authors.lastname: Brockmann
authors.forename: R
authors.initials: R
authors.lastname: Diller
authors.forename: B
authors.initials: B
authors.lastname: Suwelack
authors.forename: C F
authors.initials: CF
authors.lastname: Krieglstein
authors.forename: N
authors.initials: N
authors.lastname: Senninger
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2; D006650:Histocompatibility Testing; D006801:Humans; D006973:Hypertension; D008875:Middle Aged; D009392:Nephrectomy; D018579:Patient Selection; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement