title: Aromatic constituents of Uvaria grandiflora.
abstract: Grandiuvarone A (1) and grandiuvarins A-C (2-4) were isolated from the bark of Uvaria grandiflora. The structures of these new aromatic compounds were elucidated on the basis of spectroscopic analyses, especially 2D NMR techniques. Only compound 1 exhibited antileishmanial activity, with IC(50)/IC(90) values of 0.7/1.5 microg/mL. The positive controls pentamidine and amphotericin B had IC(50)/IC(90) values of 1.6/6.6 and 0.17/0.34 microg/mL, respectively.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
authors.forename: Sridevi
authors.initials: S
authors.lastname: Ankisetty
authors.forename: Hala N
authors.initials: HN
authors.lastname: ElSohly
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Babu L
authors.initials: BL
authors.lastname: Tekwani
authors.forename: Troy
authors.initials: T
authors.lastname: Smillie
authors.forename: Larry
authors.initials: L
authors.lastname: Walker
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D009512:New Guinea; D010082:Oxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010419:Pentamidine / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000981:Antiprotozoal Agents; D010082:Oxepins; C511034:grandiuvarone A; D010419:Pentamidine; D000666:Amphotericin B