title: Expansion of large granular lymphocytes following Pseudomonas infection in a patient with adult-onset Still's disease.
abstract: We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without any evidence of active viral activation, hemophagocytosis, or malignancies. The increased LGL cells were CD3(+)CD8(+), and disappeared promptly after the administration of antibiotics combined with prednisolone, with subsequent stabilization of her general condition.
authors.affiliation: Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi, Amagasaki, 661-0012, Japan. fumitabata@oct.zaq.ne.jp
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.forename: Hiromi
authors.initials: H
authors.lastname: Fukuda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kotani
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017252:CD3 Complex / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077731:Meropenem; D011239:Prednisolone / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000150:complications / Q000473:pathology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification* / Q000472:pathogenicity; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D013845:Thienamycins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017252:CD3 Complex; D016827:CD8 Antigens; D013845:Thienamycins; D011239:Prednisolone; D000077731:Meropenem