title: Osteosarcoma presenting as a solitary focus of osteolysis in the calvarium.
abstract: Osteolysis of the skull is fairly common. The clinical presentation and results of laboratory or imaging tests may suggest a benign or a malignant disease. However, histology is the only means of obtaining a definitive diagnosis and should therefore be performed at the slightest doubt. We report the case of a 58-year-old man who presented with a recent painless lump in the right temporoparietal region. Laboratory tests were normal. Brain imaging studies and total body radionuclide scanning showed no other lesions. However, the heterogeneous and aggressive appearance of the skull lesion prompted a surgical biopsy, which showed osteoblastic osteosarcoma. Chemotherapy and radiation therapy were given after complete excision of the tumor.
authors.affiliation: Rhumatology A Department, Paris-V University, Cochin Teaching hospital, APHP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Caramella
authors.forename: Thomas
authors.initials: T
authors.lastname: Roujeau
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Drapé
authors.forename: Krasimir
authors.initials: K
authors.lastname: Minkin
authors.forename: Claire
authors.initials: C
authors.lastname: Krainik
authors.forename: André
authors.initials: A
authors.lastname: Kahan
authors.forename: Yannick
authors.initials: Y
authors.lastname: Allanore
mesh_terms: D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000175:diagnosis / Q000209:etiology*; D012516:Osteosarcoma / Q000150:complications* / Q000175:diagnosis; D010294:Parietal Bone; D012888:Skull Neoplasms / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed