title: Fragmentation of protonated peptide ions via interaction with metastable atoms.
abstract: Fragmentation of protonated peptide ions via interaction with low kinetic energy electronicallyexcited metastable argon atoms was studied in a linear trap-time-of-flight mass spectrometer. Metastable argon atoms were generated using a glow discharge-type source. Protonated peptide ions of substance P, bradykinin, fibrinopetide A, and insulin oxidized chain B were produced by electrospray ionization and trapped in a quadrupole ion guide for 100-400 ms. Intensive series of c- and z-ions were observed in all cases. The kinetic measurements of the fragmentation rates are consistent with calculations of the reaction cross section based on the Landau-Zener approximation.
authors.affiliation: MassTech, Inc., Columbia, Maryland 21046, USA. vberkout@apmaldi.com
authors.forename: Vadym D
authors.initials: VD
authors.lastname: Berkout
mesh_terms: D001128:Argon / Q000737:chemistry*; D001665:Binding Sites; D001920:Bradykinin / Q000737:chemistry*; D005344:Fibrinopeptide A / Q000737:chemistry*; D007328:Insulin / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D007700:Kinetics; D011522:Protons; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation / Q000379:methods; D013373:Substance P / Q000737:chemistry*
chemical_list: D007328:Insulin; D007477:Ions; D011522:Protons; D005344:Fibrinopeptide A; D013373:Substance P; D001128:Argon; D001920:Bradykinin