Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
Citronellol is one monoterpene alcohol, which is present in the essential oils of various aromatic plant species. This study evaluated the neuroprotective activity of citronellol on pentylenetetrazol- and picrotoxin-induced convulsions and maximal electroshock-induced seizures in mice. Administration of citronellol significantly reduced the number of animals of convulsion induced by pentylenetetrazol and eliminated the extensor reflex of maximal electroshock-induced seizures test in about 80% of the experimental animals. In addition, administration of citronellol showed protection in the pentylenetetrazol and picrotoxin tests by increasing the latency of clonic seizures. We also investigated the effect of citronellol in the rat isolated nerve using the single sucrose-gap technique. We showed that the amplitude of the compound action potential decreased more than 90% when the monoterpene was incubated for 30 min at 6.4 mM and we did not verify any effect on the repolarization of the compound action potential. Taken together, our results demonstrated an anticonvulsant activity of the citronellol that could be, at least in part, explained by the diminution of the action potential amplitude.
de Sousa
Damião Pergentino
DP
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba (LTF/UFPB), 58051-900, João Pessoa, PB, Brazil.
Gonçalves
Juan Carlos Ramos
JC
Quintans-Júnior
Lucindo
L
Cruz
Jader Santos
JS
Araújo
Demétrius Antonio Machado
DA
de Almeida
Reinaldo Nóbrega
RN
D000200:Action Potentials / Q000187:drug effects; D000080462:Acyclic Monoterpenes; D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004597:Electroshock / Q000009:adverse effects; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000627:therapeutic use*; D009431:Neural Conduction / Q000187:drug effects; D010433:Pentylenetetrazole / Q000633:toxicity; D010852:Picrotoxin / Q000633:toxicity; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D000080462:Acyclic Monoterpenes; D000927:Anticonvulsants; D039821:Monoterpenes; D010433:Pentylenetetrazole; D010852:Picrotoxin; C007078:citronellol