Effects of exercise training on heart rate variability after coronary angioplasty.
OBJECTIVE
Cardiac autonomic dysfunction is associated with risk of restenosis and cardiovascular mortality in patients after percutaneous transluminal coronary angioplasty (PTCA). Analysis of heart rate variability (HRV) is an important, widely used method for assessing cardiac autonomic regulation. The purpose of this study was to investigate the effect of exercise training on HRV in subjects after PTCA.


METHODS
A total of 84 subjects who had undergone PTCA were recruited for this study. The subjects (age [mean+/-SD]=57.0+/-9.3 years) were randomly assigned to either an exercise group to undergo an 8-week outpatient exercise program or a control group to undergo usual care. Heart rate variability was measured for 5 minutes in the supine resting position at baseline and at the end of 8 weeks.


RESULTS
The parasympathetically modulated HRV of the subjects in the exercise group increased significantly compared with the HRV of subjects in the control group. The effects of training on HRV were independent of angioplasty type (balloon or stent) and were unrelated to whether the subjects had received previous PTCA.


CONCLUSIONS
Exercise training can increase parasympathetic modulation of cardiac function in people after they have undergone successful PTCA. Our results suggest that analysis of HRV can be extended to assess the effect of exercise training on cardiac autonomic dysfunction in people after coronary angioplasty.
Tsai
Mei-Wun
MW
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 1 Sec. 1 Jen-Ai Road, Taipei 10020, Taiwan.
Chie
Wei-Chu
WC
Kuo
Terry B J
TB
Chen
Ming-Fong
MF
Liu
Jen-Pei
JP
Chen
Tony T H H
TT
Wu
Ying-Tai
YT
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000534:rehabilitation*; D001341:Autonomic Nervous System / Q000503:physiopathology; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D010275:Parasympathetic Nervous System / Q000502:physiology / Q000503:physiopathology; D018579:Patient Selection