A facile and highly efficient route to alpha-amino phosphonates via three-component reactions catalyzed by Mg(ClO4)2 or molecular iodine.
Three-component reactions of aldehydes, amines, and diethyl phosphite catalyzed by Mg(ClO4)2 or molecular iodine afforded the corresponding alpha-amino phosphonates in excellent yields under mild reaction conditions.
Wu
Jie
J
Department of Chemistry, Fudan University, Shanghai, China. jie_wu@fudan.edu.cn
Sun
Wei
W
Xia
Hong-Guang
HG
Sun
Xiaoyu
X