Lignans from Saussurea conica and their NO production suppressing activity.
Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.
Fan
Cheng-Qi
CQ
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Zhu
Xing-Zu
XZ
Zhan
Zha-Jun
ZJ
Ji
Xin-Quan
XQ
Li
Hui
H
Yue
Jian-Min
JM
D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D030441:Saussurea / Q000737:chemistry*
D017705:Lignans; D009569:Nitric Oxide