[Progressive multifocal leukoencephalopathy secondary to JC virus infection after liver transplantation and treatment of recurrent hepatitis C].
Progressive multifocal leucoencephalopathy due to JC virus is a rare complication of liver transplantation. Only four cases have already been described in the literature. This disease is difficult to differentiate from leucoencephalopathy associated with immunosuppressive drugs such as cyclosporin or tacrolimus. Positive diagnosis of progressive multifocal leucoencephalopathy no longer requires cerebral biopsy. It must be confirmed by positive JC virus RNA amplification in the cerebrospinal fluid. We report a case of progressive multifocal leucoencephalopathy occurring 18 months after liver transplantation for hepatitis C-related cirrhosis.
Alibert
Sophie
S
Service d'Hépato-Gastroentérologie, Hôpital de la Conception, Marseille.
Gérolami
René
R
Tammam
David
D
Borentain
Patrick
P
Tissot-Dupont
Hervé
H
Zandotty
Christine
C
Hardwigsen
Jean
J
Stefaniescu
Mona
M
Barrantes
Carlos
C
Le Treut
Yves-Patrice
YP
Botta-Fridlund
Danièle
D
D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology*; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged; D012008:Recurrence