Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma.
CD30, first described as the Ki antigen on malignant B cells in Hodgkin's lymphoma, is also expressed on normal activated B and T cells. It can be cleaved from the cell surface and detected in normal serum as soluble CD30 (sCD30), where it can be an indicator of levels of immune activation. In a cross-sectional study utilizing archived sera at a time point close to but preceding a diagnosis of acquired immunodeficiency syndrome (AIDS)-associated non-Hodgkin's B cell lymphoma, AIDS lymphoma subjects (n = 49) showed elevated mean levels of sCD30 compared to controls with AIDS but no malignancy (n = 44, p < 0.01), HIV-infected but relatively healthy (n = 47, p < 0.001), or HIV-seronegative controls (n = 44, p < 0.001). Serum sCD30 was significantly correlated to serum levels of the B cell cytokines interleukin-6 (IL-6), IL-10, and sCD23, but only among lymphoma subjects (p < or = 0.05). Correlations between sCD30 and other markers of immune system activation were seen among all HIV-infected subjects (sCD27, sCD44, CXCL13, p < 0.05). These observations suggest that sCD30, especially in combination with other immune system molecules, could be an important biomarker for an immune system environment conducive to B cell hyperactivation and the development of AIDS-associated B cell lymphoma.
Breen
Elizabeth Crabb
EC
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1740, USA. ebreen@mednet.ucla.edu
Fatahi
Sepi
S
Epeldegui
Marta
M
Boscardin
W John
WJ
Detels
Roger
R
Martínez-Maza
Otoniel
O
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology; D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000503:physiopathology; D006801:Humans; D007378:Interleukins / Q000097:blood; D017730:Ki-1 Antigen / Q000097:blood*; D016483:Lymphoma, AIDS-Related / Q000097:blood / Q000276:immunology* / Q000401:mortality; D016393:Lymphoma, B-Cell / Q000097:blood / Q000276:immunology* / Q000401:mortality; D011237:Predictive Value of Tests; D016019:Survival Analysis
D015703:Antigens, CD; D015415:Biomarkers; D007378:Interleukins; D017730:Ki-1 Antigen