Genes of type 2 diabetes in beta cells.
Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.
Trajkovski
Mirko
M
Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.
Mziaut
Hassan
H
Schwarz
Peter E
PE
Solimena
Michele
M
D001324:Autoantigens / Q000235:genetics / Q000502:physiology; D002154:Calpain / Q000235:genetics* / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D011110:Polymorphism, Genetic; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000502:physiology; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8
D001324:Autoantigens; D008565:Membrane Proteins; C516862:PTPRN protein, human; D017027:Protein Tyrosine Phosphatases; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8; D002154:Calpain; C415197:calpain 10