Congenital coxsackievirus B5 infection: report of one case.
In infants and children, enterovirus (EV) infections are very common. In neonates, EV infections may lead to fatal myocarditis, encephalitis, or necrotizing hepatitis. Transplacental viremia before delivery is possible but has only been demonstrated occasionally. The presence or absence of passively acquired maternal antibody specific for the infecting EV serotype plays the most important role in neonatal EV infections. We report a fatal case of congenital coxsackievirus B5 infection, confirmed by culture of the virus from the patient's throat and rectal swab and from his mother's throat. The mother had suffered from fever for 1 week since 9 days before delivery. Fever subsided 2 days before the day of delivery, but absence of fetal movements was noted. The newborn's 4-year-old elder sister also had suffered from fever with upper respiratory symptoms during the same period. Fever occurred in this baby immediately after birth by cesarean section, suggesting the presence of transplacental virus transmission.
Kao
Yu-Hsuan
YH
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan. evakao@ms1.mmh.org.tw
Hung
Han-Yang
HY
Chi
Hsin
H
D029822:Enterovirus B, Human; D004769:Enterovirus Infections / Q000151:congenital* / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male