Avellino corneal dystrophy exacerbated after LASIK: scanning electron microscopic findings.
OBJECTIVE
To evaluate the ultrastructure of the cornea of Avellino corneal dystrophy (ACD) exacerbated by LASIK.


METHODS
Three ACD patients with exacerbation of granular corneal deposits after LASIK underwent surgical removal of the corneal flap. The corneal flap was processed for scanning electron microscopy (SEM).


RESULTS
SEM of all patients showed abnormal granular clusters in the fibrils of the corneal flap.


CONCLUSIONS
Laser in situ keratomileusis induces corneal collagen abnormalities and adhesions of granular material in ACD patients.
Roh
Mi In
MI
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seodaemun-ku, Seoul, Korea.
Grossniklaus
Hans E
HE
Chung
So-Hyang
SH
Kang
Shin Jeong
SJ
Kim
Woon Cho
WC
Kim
Eung Kweon
EK
D000328:Adult; D003317:Corneal Dystrophies, Hereditary / Q000209:etiology* / Q000648:ultrastructure*; D003319:Corneal Stroma / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D013524:Surgical Flaps / Q000473:pathology*