Transplantation of bone marrow derived progenitor cells in acute myocardial infarction. The first results.
The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in two patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.
Pudil
Radek
R
Charles University Prague, 1st Department of Medicine, Faculty of Medicine, Hradec Králové and University Hospital Hradec Králové, Czech Republic. pudilradek@yahoo.com
Vojádek
Jan
J
Filip
Stanislav
S
Mericka
Pavel
P
St'ásek
Josef
J
Straková
Hana
H
Vokurková
Doris
D
Solar
Miroslav
M
Mokrý
Jaroslav
J
Dominik
Jan
J
Malý
Jaroslav
J
D000328:Adult; D016026:Bone Marrow Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology; D012038:Regeneration; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left