title: Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial.
abstract: BACKGROUND
  Chronic infections, such as periodontitis, are associated with increased risk of systemic diseases driven by a persistent low-grade systemic inflammation and metabolic changes. Severity of periodontitis has also been associated with increased systolic blood pressure (BP). However, the issue remains poorly investigated. We aimed to estimate the effect of periodontal therapy on traditional and novel cardiovascular risk factors in systemically healthy individuals who have periodontitis.
  
  
  METHODS
  We enrolled 40 otherwise healthy patients with severe chronic generalized periodontitis in a 6-month pilot intervention trial. Individuals were randomized either to a standard course of periodontal therapy (subgingival scaling and root planing) or an intensive one (including the adjunctive use of a locally delivered antimicrobial, IPT).
  
  
  RESULTS
  Compared to control, IPT produced significant reductions in a cluster of inflammatory markers at 1 (P = .0406) and 2 (P = .0060) months together with an improvement in lipid markers at 2 (P = .0320) and 6 (P = .0432) months after therapy. Intensive periodontal therapy produced greater reductions in IL-6 at 1 (0.4 +/- 0.2 ng/L difference, 95% CI 0.03-0.9, P = .0284) and 2 months (0.3 +/- 0.2 ng/L difference, 95% CI 0.1-0.8, P = .0284), together with decreases in C-reactive protein (0.4 +/- 0.2 mg/L difference, 95% CI 0.01-0.8, P = .0438) and total cholesterol (0.3 +/- 0.1 mmol/L difference, 95% CI 0.04-0.6, P = .0254). Moreover, a 7 +/- 3-mm Hg decrease in systolic BP was observed at 2 months in the IPT group (95% CI 1-12, P = .0211), and this difference was greater in current smokers (14 +/- 5 mm Hg 95% CI 3-25, P = 0.0124). Intensive periodontal therapy subjects exhibited a 1.53% +/- 1.20% (95% CI 1.05-2.24, P = .0290) and 2.00% +/- 1.42% (95% CI 0.98-4.09, P = .0568) decreases in cardiovascular risk scores (Framingham) at 2 and 6 months, respectively, when compared to those in the standard group.
  
  
  CONCLUSIONS
  Our findings suggest that intensive periodontal treatment reduces systemic inflammatory markers and systolic BP, and improves lipid profiles with subsequent changes in cardiovascular risk when compared to standard therapy.
authors.affiliation: Department of Periodontology, Eastman Clinical Investigation Centre, University College London, London, United Kingdom.
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Aiuto
authors.forename: Mohamed
authors.initials: M
authors.lastname: Parkar
authors.forename: Luigi
authors.initials: L
authors.lastname: Nibali
authors.forename: Jean
authors.initials: J
authors.lastname: Suvan
authors.forename: Jan
authors.initials: J
authors.lastname: Lessem
authors.forename: Maurizio S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D007249:Inflammation / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D010865:Pilot Projects; D012307:Risk Factors; D016745:Root Planing
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D008055:Lipids