title: Granulomatous hepatitis and hemophagocytic syndrome after bacillus Calmette-Guerin bladder instillation.
abstract: Intravesical instillations of bacillus Calmette-Guérin are frequently used for treating superficial bladder carcinoma which is considered a safe treatment. We describe an unusual complication with hemophagocytosis and granulomatous hepatitis. Prompt diagnosis and treatment with corticosteroids, anti-tuberculous agents and intravenous immunoglobulins led to a rapid recovery.
authors.affiliation: Service d'Hépatologie et de Soins Intensifs Digestifs, Centre Hospitalier Louis Pasteur, Dole. tthevenot@chu-besancon.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Thevenot
authors.forename: Vincent
authors.initials: V
authors.lastname: Di Martino
authors.forename: Aurélie
authors.initials: A
authors.lastname: Lagrange
authors.forename: Tony
authors.initials: T
authors.lastname: Petrella
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Faucher
authors.forename: Jean
authors.initials: J
authors.lastname: Fontan
authors.forename: Mélanie
authors.initials: M
authors.lastname: Terebus
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Miguet
authors.forename: Solange
authors.initials: S
authors.lastname: Bresson-Hadni
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D006099:Granuloma / Q000209:etiology*; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D008297:Male
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine