Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature.
METHODS
The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years.


METHODS
Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.
Piccirilli
Manolo
M
Department of Neurosurgical Sciences, Neurosurgery, University of Rome, La Sapienza, Rome, Italy.
Lenzi
Jacopo
J
Delfinis
Catia
C
Trasimeni
Guido
G
Salvati
Maurizio
M
Raco
Antonino
A
D002675:Child, Preschool; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology; D020339:Optic Nerve Glioma / Q000150:complications* / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000150:complications* / Q000473:pathology; D012196:Review Literature as Topic