title: Anastomotic biliary strictures after liver transplantation: causes and consequences.
abstract: We retrospectively studied the prevalence, presentation, results of treatment, and graft and patient survival of grafts developing an anastomotic biliary stricture (AS) in 531 adult liver transplantations performed between 1979 and 2003. Clinical and laboratory information was obtained from the hospital files, and radiological studies were re-evaluated. Twenty-one possible risk factors for the development of AS (variables of donor, recipient, surgical procedure, and postoperative course) were analyzed in a univariate and stepwise multivariate model. Forty-seven grafts showed an anastomotic stricture: 42 in duct-to-duct anastomoses, and 5 in hepaticojejunal Roux-en-Y anastomoses. The cumulative risk of AS after 1, 5, and 10 years was 6.6%, 10.6%, and 12.3% respectively. Postoperative bile leakage (P = 0.001), a female donor/male recipient combination (P = 0.010), and the era of transplantation (P = 0.006) were independent risk factors for the development of an AS. In 47% of cases, additional (radiologically minor) nonanastomotic strictures were diagnosed. All patients were successfully treated by 1 or more treatment modalities. As primary treatment, endoscopic retrograde cholangiopancreaticography (ERCP) was successful in 24 of 36 (67%) cases and percutaneous transhepatic cholangiodrainage in 4 of 11 (36%). In the end 15 patients (32%) were operated, all with long-term success. AS presenting more than 6 months after transplantation needed more episodes of stenting by ERCP, and more stents per episode compared to those presenting within 6 months and recurred more often. Graft and patient survival were not impaired by AS.
authors.affiliation: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Verdonk
authors.forename: Carlijn I
authors.initials: CI
authors.lastname: Buis
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Porte
authors.forename: Eric J
authors.initials: EJ
authors.lastname: van der Jagt
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Limburg
authors.forename: Aad P
authors.initials: AP
authors.lastname: van den Berg
authors.forename: Maarten J H
authors.initials: MJ
authors.lastname: Slooff
authors.forename: Paul M J G
authors.initials: PM
authors.lastname: Peeters
authors.forename: Koert P
authors.initials: KP
authors.lastname: de Jong
authors.forename: Jan H
authors.initials: JH
authors.lastname: Kleibeuker
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Haagsma
mesh_terms: D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002779:Cholestasis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D004724:Endoscopy; D005260:Female; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015995:Prevalence