title: Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex.
abstract: The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.
authors.affiliation: Division of Pediatric Neurology, The Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. joycewu@mednet.ucla.edu
authors.forename: J Y
authors.initials: JY
authors.lastname: Wu
authors.forename: W W
authors.initials: WW
authors.lastname: Sutherling
authors.forename: S
authors.initials: S
authors.lastname: Koh
authors.forename: N
authors.initials: N
authors.lastname: Salamon
authors.forename: R
authors.initials: R
authors.lastname: Jonas
authors.forename: S
authors.initials: S
authors.lastname: Yudovin
authors.forename: R
authors.initials: R
authors.lastname: Sankar
authors.forename: W D
authors.initials: WD
authors.lastname: Shields
authors.forename: G W
authors.initials: GW
authors.lastname: Mathern
mesh_terms: D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity; D014402:Tuberous Sclerosis / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D014743:Videotape Recording
chemical_list: D019788:Fluorodeoxyglucose F18