Immunoglobulin GM and KM allotypes and prevalence of anti-LKM1 autoantibodies in patients with hepatitis C virus infection.
GM and KM allotypes-genetic markers of immunoglobulin (Ig) gamma and kappa chains, respectively-are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P=0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.
Muratori
Paolo
P
Department of Internal Medicine, Alma Mater Stadiorum-University of Bologna, Italy.
Sutherland
Susan E
SE
Muratori
Luigi
L
Granito
Alessandro
A
Guidi
Marcello
M
Pappas
Georges
G
Lenzi
Marco
M
Bianchi
Francesco B
FB
Pandey
Janardan P
JP
D001323:Autoantibodies / Q000096:biosynthesis*; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000096:biosynthesis*; D007131:Immunoglobulin Km Allotypes / Q000096:biosynthesis* / Q000235:genetics; D016130:Immunophenotyping
D001323:Autoantibodies; D005819:Genetic Markers; D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes; C060729:anti-liver kidney microsome antibody