Reproductive outcomes of maternal contamination with cyclodiene insecticides, hexachlorobenzene and beta-benzene hexachloride.
The effects of organochlorines on human reproduction have been recently under scrutiny. Some negative effects on animal reproduction have been reported. In this study we aimed to evaluate the effect of maternal contamination with a certain group of organochlorines, which are cyclodienes, HCB (hexachlorobenzene) and beta-BHC (beta-hexachlorocyclohexane) on human reproduction. Breast milk samples from 815 eligible Victorian mothers were used for measuring maternal contamination and the reproductive outcomes such as birth weight, head circumference and prematurity were taken from health files. Our study did not show any significant negative effect on outcomes such as birth weight, small for gestation age, previous miscarriage or still birth, head circumference or sex ratio. An inconsistent increase across oxychlordane exposure levels for prematurity was found. We also found an inverse association between the highest levels of HCB and oxychlordane with previous miscarriage or still birth; but this was based on small numbers and may be explained by loss of contaminants through the aborted fetus. These results suggest that the declining contamination levels of these chemicals do not impose a threat to human reproduction.
Khanjani
Narges
N
Centre for Occupational and Environmental Health, Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia. narges.khanjani@med.monash.edu.au
Sim
Malcolm Ross
MR
D001724:Birth Weight; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000633:toxicity*; D007231:Infant, Newborn; D007306:Insecticides / Q000032:analysis / Q000633:toxicity*; D008297:Male; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry; D010573:Pesticide Residues / Q000032:analysis / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012744:Sex Ratio
D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D010573:Pesticide Residues