CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain.
Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.
Ao
Hushan
H
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. hao@im.wustl.edu
Ko
Shanelle W
SW
Zhuo
Min
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D002470:Cell Survival; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000166:cytology* / Q000378:metabolism*; D051379:Mice; D009154:Mutation / Q000235:genetics; D017966:Pyramidal Cells / Q000166:cytology* / Q000378:metabolism*
D017362:Cyclic AMP Response Element-Binding Protein