title: Pattern-based discrimination of enantiomeric and structurally similar amino acids: an optical mimic of the mammalian taste response.
abstract: This manuscript describes an optical enantioselective pattern-based sensing array. A differential array of enantioselective indicator displacement assays was constructed and used to demonstrate simultaneous discrimination of enantiomeric and structurally similar alpha-amino acids. Interpretation of the output patterns by principle component analysis leads to the separation of enantio- and chemoselective information along orthogonal variance axes when chiral receptors of opposite enantiomeric preference are included. A general principle is delineated that correlates array design with the achievement of enantiomeric discrimination analogous to the mammalian gustation response to the amino acids.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: J Frantz
authors.initials: JF
authors.lastname: Folmer-Andersen
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitamura
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D008322:Mammals / Q000502:physiology*; D013237:Stereoisomerism; D013649:Taste
chemical_list: D000596:Amino Acids