title: Bacterial entry into cells: a role for the endocytic machinery.
abstract: Increasing evidence indicates that pathogens have evolved highly efficient strategies to induce their internalization within host cells. Viruses and bacteria express and expose on their surface, molecules that mimic endogenous ligands to cell receptors, thereby inducing specific intracellular signalling cascades. More recently it has become clear that, as most viruses, bacteria can enter cells via the clathrin-mediated pathway, indicating a key role for endocytosis in pathogens entry into cells. Here we review the pathways followed by Listeria monocytogenes to enter into non-phagocytic cells, as a model for the subversion of cellular functions to induce pathogens internalization.
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris F-75015, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bonazzi
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000502:physiology; D002966:Clathrin / Q000502:physiology; D004705:Endocytosis; D008055:Lipids / Q000502:physiology; D008087:Listeria / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D002966:Clathrin; D008055:Lipids; D008565:Membrane Proteins; C095768:inlB protein, Listeria monocytogenes