title: Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.
abstract: Ovary cancer invasion is responsible for both local tissue destruction and distant metastasis. Invasion is largely mediated by matrix metalloproteases that are thought to be induced by tumor cell-derived extracellular matrix metalloprotease inducer (EMMPRIN) in surrounding fibroblasts. We hypothesized that EMMPRIN isoverexpressed in ovary tumors. Immunohistochemical analysis of EMMPRIN was performed in tissue microarrays of ovary neoplasms including 84 cases of serous adenocarcinoma, 23 cases of mucinous adenocarcinoma, 10 cases of endometrioid adenocarcinoma, 12 cases of yolk sac tumor, 12 cases of clear cell carcinoma, 8 cases of dysgerminoma, 8 cases of granulosa cell tumor, 6 cases of transitional cell carcinoma, and 6 cases of Brenner tumor. All malignant ovary tumors showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in malignant ovary tumors were significantly higher than their nontumor counterparts (313+/-28 for serous adenocarcinoma; 308+/-25 for mucinous adenocarcinoma; 187+/-19 for endometrioid adenocarcinoma; 265+/-23 for yolk sac tumors; 87+/-13 for clear cellcarcinoma; 126+/-15 for dysgerminoma; 243+/-26 for granulosa cell tumor; 87+/-16 for transitional cell carcinoma). The EMMPRIN score was significantly higher in serous adenocarcinomas than in serous adenomas and serous borderline tumors and was correlated with nodal stage. Our findings show for the first time that EMMPRIN is overexpressed in all malignant ovary tumors.
authors.affiliation: Department of Pathology, and Division of Urology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Jong-Shiaw
authors.initials: JS
authors.lastname: Jin
authors.forename: Chen-Wen
authors.initials: CW
authors.lastname: Yao
authors.forename: Shih-Hurng
authors.initials: SH
authors.lastname: Loh
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Cheng
authors.forename: Dar-Shih
authors.initials: DS
authors.lastname: Hsieh
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Bai
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D051926:Basigin / Q000032:analysis* / Q000235:genetics; D001948:Brenner Tumor / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D004407:Dysgerminoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D018240:Endodermal Sinus Tumor / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology*; D046888:Tissue Array Analysis
chemical_list: D051926:Basigin