title: Clinical and genetic assessments of hip joint laxity in the Boykin spaniel.
abstract: Canine hip dysplasia (CHD) is characterized by a malformation of the hip joint that leads to joint laxity and consequential degenerative joint disease. The most widely used method for diagnosis of CHD is the ventrodorsal hip-extended radiologic view, commonly referred to as the Orthopedic Foundation for Animals (OFA) method. The method of the University of Pennsylvania Hip Improvement Program (PennHIP), an alternative technique that is based on hip joint laxity, provides a quantitative assessment, the distraction index (DI), of the likelihood of the development of CHD because of increased laxity in the hip joint. Linear regression analysis showed that, across many breeds of dog, the incidence of CHD, as defined by the OFA, is positively correlated with the mean DI, the determination coefficient (r2) being 26%. We used families of Boykin spaniels (BSs) to determine the level of joint laxity in the breed and to conduct an initial whole-genome screening to identify markers that co-segregate with increased joint laxity. Although there was a positive correlation between the incidence of hip dysplasia and increased joint laxity, we did not find significant linkage in the 28 BSs that underwent genotyping, likely owing to the small size of the pedigree.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77845-4467, USA.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Tsai
authors.forename: Keith E
authors.initials: KE
authors.lastname: Murphy
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D004285:Dogs; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006619:Hip Dysplasia, Canine / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers