[Design and manufacture of microneedles array for transdermal drug delivery].
It is very important to disrupt the stratum corneum structure and to create pathways allowing transport of macromolecules, as the traditional transdermal drug delivery has been severely limited by the skin barrier. With the development of the Micro Electro-Mechanical System (MEMS), it becomes possible for microneedles array to strengthen the transdermal drug delivery. In addition to the increase of the skin permeability, it can also be used to deliver drugs into skin, such as insulin and vaccine, providing a new direction for drug delivery systems. In this paper, we review the development and applications in transdermal drug delivery of microneedles' array. The commercial prospects and recommendations for the future research work are also represented.
Zhang
Jun-yong
JY
School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan. i_fuleyou@126.com
Zhao
Ying-jun
YJ
Yang
Xiang-liang
XL
D000279:Administration, Cutaneous; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D055617:Micro-Electrical-Mechanical Systems; D008845:Microinjections; D009339:Needles