Benefits of combining aripiprazole to clozapine: three case reports.
OBJECTIVE
A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine.


METHODS
Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment.


RESULTS
Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine.


CONCLUSIONS
The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients.
Rocha
Fábio Lopes
FL
Rua dos Otoni, 106, Santa Efigênia, 30150.270, Belo Horizonte, MG, Brazil. rochafl@uol.com.br
Hara
Cláudia
C
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000068180:Aripiprazole; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D015363:Quinolones / Q000009:adverse effects / Q000627:therapeutic use*; D012562:Schizophrenia, Disorganized / Q000188:drug therapy / Q000523:psychology; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000523:psychology
D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D003024:Clozapine