title: Preprocedural statin use is associated with a reduced hazard of postprocedural myonecrosis in patients undergoing rotational atherectomy--a propensity-adjusted analysis.
abstract: Incidence of myonecrosis in patients undergoing rotational atherectomy was evaluated by preprocedural statin use. The incidence of any myonecrosis (24.1% vs 52.3%, P < .001) or significant myonecrosis (7.5% vs 21.8%, P < .001) was significantly lower among patients pretreated with statins. This difference remained significant after multivariable and propensity adjustment.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA. hgurm@med.umich.edu
authors.forename: Hitinder S
authors.initials: HS
authors.lastname: Gurm
authors.forename: Yuri
authors.initials: Y
authors.lastname: Breitbart
authors.forename: Deepak
authors.initials: D
authors.lastname: Vivekanathan
authors.forename: Michael H
authors.initials: MH
authors.lastname: Yen
authors.forename: Robert
authors.initials: R
authors.lastname: Fathi
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Ziada
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Whitlow
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ellis
mesh_terms: D000368:Aged; D017225:Atherectomy, Coronary / Q000009:adverse effects; D009202:Cardiomyopathies / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003327:Coronary Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000453:epidemiology / Q000517:prevention & control; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D012720:Severity of Illness Index
chemical_list: D002316:Cardiotonic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex