Anti-inflammatory properties of Type I interferons.
The notion that Type I interferons (interferon-alpha and -beta) possess anti-inflammatory potential is supported by data from clinical application in multiple sclerosis, by studies on cultured immune-competent cells and by investigation of experimental diseases in whole animals. These observations deserve the attention of virologists for their potential role in the pathogenesis and clinical management of virus infections.
Billiau
Alfons
A
Rega Institute, University of Leuven, Minderbroedersstraat 10, BE-3000 Leuven, Belgium. Alfons.Billiau@Rega.Kuleuven.be
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009103:Multiple Sclerosis / Q000188:drug therapy*; D014777:Virus Diseases / Q000188:drug therapy*
D000998:Antiviral Agents; D007370:Interferon Type I