Acute oxcarbazepine, benazepril, and hydrochlorothiazide overdose with alcohol.
An epiletic patient, suffering from partial complex seizures and hypertension, ingested approximately 42 g of oxcarbazepine (OXC) and an undefined number of tablets containing an association of benazepril and hydrochlorothiazide along with some glasses of wine. Four hours later he was brought to the emergency room. He was stuporous and gradually became unconscious. Therefore he was intubated and, approximately 6 hours after the overdose, transferred to the intensive care unit, where he underwent a 4-hour hemodialysis. Even if this procedure did not accelerate the elimination of the prodrug nor its active metabolite (monohydrocarbazepine), 3 hours after the end of dialysis the patient was fully recovered.
Furlanut
Mario
M
Department of Pharmacology, Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, Udine, Italy. mario.furlanut@med.uniud.it
Franceschi
Loretta
L
Poz
Donatella
D
Silvestri
Luciano
L
Pecorari
Maurizio
M
D000927:Anticonvulsants / Q000378:metabolism / Q000506:poisoning / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000506:poisoning / Q000627:therapeutic use; D001552:Benzazepines / Q000627:therapeutic use; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000506:poisoning / Q000627:therapeutic use; D003422:Critical Care; D004232:Diuretics / Q000506:poisoning / Q000627:therapeutic use; D062787:Drug Overdose; D006801:Humans; D006852:Hydrochlorothiazide / Q000506:poisoning* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D020127:Recovery of Function; D006435:Renal Dialysis; D013607:Tablets; D013997:Time Factors; D014920:Wine
C039775:10,11-dihydro-10-hydroxycarbamazepine; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D001552:Benzazepines; D004232:Diuretics; D013607:Tablets; D006852:Hydrochlorothiazide; D002220:Carbamazepine; C044946:benazepril; D000078330:Oxcarbazepine