title: Hemodynamics of a pulsatile left ventricular assist device driven by a counterpulsation pump in a mock circulation.
abstract: The BCM (CardialCare, Minneapolis, MN, U.S.A.) is a pusher-plate pulsatile left ventricular assist device (LVAD) that is operated by counterpulsation pumps. The purpose of this work was to assess the fluid dynamics associated with operating the BCM in a mock circulation, and also to examine the similarities between hemodynamic parameters produced by this device in vitro and those produced by the left ventricle (LV) in vivo. The BCM was connected to a true size silicon rubber aorta and operated by an intra-aortic balloon pump. We examined the performance of the device at two system pressures (6.5 and 8 kPa); at three heart rates (60, 80, and 100 bpm); and at three pumping frequencies (1:1, 1:2, 1:3). Pressure and flow were measured in the upper descending aorta, and wave intensity analysis was used to calculate the peak intensity and energy of the compression and expansion waves. Pressure and flow waveforms produced by the BCM LVAD in vitro under different loading conditions were similar to those observed in vivo under similar loadings. Pusher-plate-type LVADs can produce compression and expansion waves similar to those generated by healthy LV in vivo.
authors.affiliation: Brunel Institute for Bioengineering and School of Engineering and Design, Brunel University, Uxbridge, Middlesex, England. ashraf.khir@brunel.ac.uk
authors.forename: Ashraf William
authors.initials: AW
authors.lastname: Khir
authors.forename: Marcel J
authors.initials: MJ
authors.lastname: Swalen
authors.forename: Patrick
authors.initials: P
authors.lastname: Segers
authors.forename: Pascal
authors.initials: P
authors.lastname: Verdonck
authors.forename: John R
authors.initials: JR
authors.lastname: Pepper
mesh_terms: D001011:Aorta / Q000502:physiology; D003326:Coronary Circulation; D006353:Heart-Assist Devices; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D008422:Materials Testing; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology