Antidyslipidemic activity of furano-flavonoids isolated from Indigofera tinctoria.
Flavonoids appear to play a major role in reducing the risk of cardiovascular diseases by decreasing the blood lipid levels. In continuation of our drug discovery program on antidyslipidemic agents we have isolated three furano-flavones 1-3 and a rare flavonol glycoside 4 from the aerial parts of Indigofera tinctoria. Our results disclose that the treatment with diastereomeric flavonoid mixture 1 and 2 (80:20) significantly decreased the plasma triglycerides (TG) by 60%, total cholesterol (TC) 19%, glycerol (Gly) 13%, and free fatty acid (FFA) 25% accompanied with increase in high density lipoproteins-cholesterol (HDL-C) by 8% and HDL-C/TC ratio 36% in high fat diet (HFD) fed dyslipidemic hamsters at the dose of 50 mg/kg body weight. The flavonoid 3 has exhibited moderate antidyslipidemic activity.
Narender
Tadigoppula
T
Division of Medicinal and Process Chemistry, Lucknow, India. tnarender@rediffmail.com
Khaliq
Tanvir
T
Puri
Anju
A
Chander
Ramesh
R
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D006224:Cricetinae; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification*; D005663:Furans / Q000737:chemistry*; D005990:Glycerol / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification*; D029883:Indigofera / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D005227:Fatty Acids; D005419:Flavonoids; D005663:Furans; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D005990:Glycerol