title: [Monoclonal antibodies: technology around the clock for new therapeutic hopes].
abstract: Engineering monoclonal antibodies, now widely used in the clinic, has made it possible to develop a new generation of antibodies with optimized functional properties. These antibodies should allow a significant improvement of the treatment of diseases where only few drugs are available, if any. However, the cost of treatments with monoclonal antibodies requires further improvements in production and purification technologies, and raises the question of generic antibodies. The present review summarizes some of the technological past and present challenges in the field.
authors.affiliation: Département Recherche, Laboratoire Français du Fractionnement et des Biotechnologies, 3, av. des Tropiques, BP 305, Les Ulis, 91958 Courtaboeuf, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bourel
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Teillaud
mesh_terms: D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000627:therapeutic use*; D005818:Genetic Engineering; D006801:Humans; D013672:Technology / Q000639:trends*
chemical_list: D000911:Antibodies, Monoclonal