title: Supporting epoetin alfa stimulated erythropoiesis: identifying appropriate iron levels: case study of the anemic patient.
abstract: Stimulation of red blood cell precursors by Epoetin alfa results in a predictable, dose-dependent increase in red blood cell mass. Iron is an important substrate that supports red blood cell and hemoglobin development. Patients who receive Epoetin alfa therapy typically require intravenous iron supplementation to ensure proper red cell formation. Target and ceiling iron levels should be determined on the basis of safety considerations, the predicted clinical response, and individual patient replacement needs. Nurses can use clinical parameters such as body weight, baseline and target hemoglobin values, and iron losses from blood and other sources to estimate iron replacement doses, thereby providing a guide for appropriate iron replacement.
authors.affiliation: Everest Healthcare Services Corp. Oak Park, Illinois, USA.
authors.forename: C
authors.initials: C
authors.lastname: Sasak
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods* / Q000451:nursing; D004359:Drug Therapy, Combination; D000068817:Epoetin Alfa; D004909:Erythrocyte Indices; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology / Q000627:therapeutic use*; D005293:Ferritins / Q000097:blood; D006397:Hematinics / Q000494:pharmacology / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D058085:Iron Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D019190:Iron Overload / Q000209:etiology / Q000517:prevention & control; D007676:Kidney Failure, Chronic / Q000150:complications*; D024802:Nurse's Role; D009730:Nursing Assessment; D011994:Recombinant Proteins; D006435:Renal Dialysis / Q000009:adverse effects; D017751:Safety Management; D014168:Transferrin / Q000378:metabolism
chemical_list: D006397:Hematinics; D006454:Hemoglobins; D058085:Iron Compounds; D011994:Recombinant Proteins; D014168:Transferrin; D004921:Erythropoietin; D000068817:Epoetin Alfa; D005293:Ferritins