[Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project].
OBJECTIVE
To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs.


METHODS
Molecular epidemiology study.


METHODS
S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs.


METHODS
50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits.


METHODS
Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2).


RESULTS
19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups.


CONCLUSIONS
This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.
Bolognesi
Claudia
C
Struttura di cancerogenesi ambientale, Istituto nazionale per la ricerca sul cancro, Genova. claudia.bolognesi@istge.it
Nucci
Maria Concetta
MC
Colacci
Anna Maria
AM
Grilli
Sandro
S
Ippoliti
Flora
F
Mucci
Nicolina
N
Romano Spica
Vincenzo
V
Barbieri
Anna
A
Canitano
Nicoletta
N
Chiozzotto
Daniela
D
Di Renzo
Livia
L
Giordano
Elena
E
Horn
Wolfango
W
Roggieri
Paola
P
Risi
Alessandro
A
Silingardi
Paola
P
Vaccari
Monica
M
Violante
Francesco Saverio
FS
D000328:Adult; D000970:Antineoplastic Agents / Q000652:urine*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D009726:Nurses; D016273:Occupational Exposure / Q000032:analysis*
D000970:Antineoplastic Agents