title: Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival.
abstract: Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IkappaBalpha, a marker of NF-kappaB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IkappaBalpha expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.
authors.affiliation: Pathology Unit, National Cancer Institute Giovanni Pascale, Naples, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Franco
authors.forename: Francisca I
authors.initials: FI
authors.lastname: Camacho
authors.forename: Alessia
authors.initials: A
authors.lastname: Caleo
authors.forename: Stefania
authors.initials: S
authors.lastname: Staibano
authors.forename: Delfina
authors.initials: D
authors.lastname: Bifano
authors.forename: Amalia
authors.initials: A
authors.lastname: De Renzo
authors.forename: Fausto
authors.initials: F
authors.lastname: Tranfa
authors.forename: Anna
authors.initials: A
authors.lastname: De Chiara
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.forename: Roberta
authors.initials: R
authors.lastname: Merola
authors.forename: Ana
authors.initials: A
authors.lastname: Diez
authors.forename: Giulio
authors.initials: G
authors.lastname: Bonavolontà
authors.forename: Gaetano
authors.initials: G
authors.lastname: De Rosa
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Piris
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D000074018:B-Cell CLL-Lymphoma 10 Protein; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005134:Eye Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D015996:Survival Rate; D046888:Tissue Array Analysis; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins