title: Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470.
abstract: Potential inhibitory effects of the antiangiogenic drug TNP-470 on rat urinary bladder carcinogenesis were investigated in F344 male rats initiated with 0.05% BBN in the drinking water for 8 weeks. Group 1 was then continuously treated with TNP-470 by subcutaneous injection using osmotic minipump until the end of the experiment; group 2 served as the control with only initiation. The incidences and multiplicities of papillomas and carcinomas in the TNP-470-treated group were significantly decreased compared to the control group values along with the tumor vascular density. In conclusion, TNP-470 can inhibit rat urinary bladder carcinogenesis, presumably through its effects on angiogenesis.
authors.affiliation: Department of Pathology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan. wani@med.osaka-cu.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Wanibuchi
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.forename: Elsayed I
authors.initials: EI
authors.lastname: Salim
authors.forename: Anna
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Keiichirou
authors.initials: K
authors.lastname: Morimura
authors.forename: Katsuichi
authors.initials: K
authors.lastname: Sudo
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D001707:Biopsy, Needle; D015152:Blotting, Northern; D002085:Butylhydroxybutylnitrosamine; D016009:Chi-Square Distribution; D003510:Cyclohexanes; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007150:Immunohistochemistry; D008297:Male; D009374:Neoplasms, Experimental; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D011336:Probability; D012333:RNA, Messenger / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D012680:Sensitivity and Specificity; D012717:Sesquiterpenes / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D020533:Angiogenesis Inhibitors; D003510:Cyclohexanes; D012333:RNA, Messenger; D012717:Sesquiterpenes; D042461:Vascular Endothelial Growth Factor A; D002085:Butylhydroxybutylnitrosamine; D000077609:O-(Chloroacetylcarbamoyl)fumagillol