title: Single dose of cefodizime completely eradicated multidrug-resistant strain of Neisseria gonorrhoeae in urethritis and uterine cervicitis.
abstract: Cefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gonorrhoeae, a clinical trial of single-dose therapy of CDZM for gonococcal urethritis and uterine cervicitis was conducted. N. gonorrhoeae was eradicated from 100% of patients with gonococcal urethritis and uterine cervicitis by a single dose of CDZM. In conclusion, CDZM is one of most suitable drugs for the treatment of gonococcal genital infection in the era of multidrug-resistant N. gonorrhoeae.
authors.affiliation: Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. t-matsu@med.uoeh-u.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Muratani
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ando
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sato
authors.forename: Masako
authors.initials: M
authors.lastname: Kurashima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yokoo
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ikuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yanai
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology*; D002575:Uterine Cervicitis / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002439:Cefotaxime; C033356:cefodizime