Phenolic constituents from Perovskia atriplicifolia.
Perovskoate, an isorinic acid derivative (1) and perovskoside, the catechol derivative (2) have been isolated from the ethyl acetate soluble fraction of the whole plant of Perovskia atriplicifolia and assigned the structure 3(7-hydroxyphenyl)-2-hydroxy propanoic acid; (R)-form, 2-O-(6',7'-dihydroxy-E-cinnamoyl) (1) and 2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol (2). In addition, caffeic acid (3) and ferulic acid (4) have been reported for the first time from this species. The structures of these compounds were assigned on the basis of 1D and 2D NMR techniques. The compound 1 showed significant inhibitory activity against lipoxygenase and weak to moderate activity against cholinesterases.
Perveen
Shagufta
S
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Khan
Sher Bahadar
SB
Malik
Abdul
A
Tareen
Rasool Bakhsh
RB
Nawaz
Sarfraz Ahmad
SA
Choudhary
Muhammad Iqbal
MI
D002109:Caffeic Acids / Q000737:chemistry; D002396:Catechols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007773:Lactates; D019686:Lamiaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C512672:2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol; C512671:3-(4-hydroxyphenyl)-2-hydroxypropanoic acid; D002109:Caffeic Acids; D002396:Catechols; D002800:Cholinesterase Inhibitors; D003373:Coumaric Acids; D007773:Lactates; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D011422:Propionates; C004999:ferulic acid; C040048:caffeic acid