The interrelation of birth weight and regional lipid deposition: a twins study.
This study examined the hypothesis that low birth weight is associated with changes in regional lipid deposition as well as insulin sensitivity in adult twins. Eleven adult female twin pairs were studied by magnetic resonance to determine regional adiposity. Their insulin sensitivity was assessed by the homeostasis model assessment. There were significant associations between birth weight and current homeostasis model assessment value (r=-0.528, P=.012), abdominal visceral (r=-0.581, P=.005), and subcutaneous fat volumes (r=-0.638, P=.001) if the group of 22 subjects were analyzed as individuals. There were no significant associations of the intratwin pair difference in birth weight and differences between adult twins in these same variables possibly because of limited patient numbers. Reduced birth weight does confer an increased risk of abdominal adiposity as well as insulin resistance in twin populations as it does in the general population.
Hng
Tien-Ming
TM
Centre for Diabetes and Endocrinology Research, Westmead Hospital, Westmead NSW 2145, and Department of General Medicine, Flinders Medical Centre, Flinders University of South Australia, Beford Park, Australia.
McLean
Mark
M
Cheung
N Wah
NW
Thompson
Campbell H
CH
D050153:Abdominal Fat / Q000378:metabolism*; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D018709:Statistics, Nonparametric