title: Modifying integra as a regeneration template in deep tissue planes.
abstract: Contour defects resulting in deformity caused by lack of tissue can be improved by conventional surgery using autologous tissue, but there is always a donor site morbidity. Integra has been available since the early 1980's for use in acute burns and more recently in reconstruction. It has been shown histologically to act as a tissue regeneration template. The regenerated dermis is buried under an autologous thin split-skin graft. In this study, the principle of burying Integra (without the silicone layer) has been applied to deep tissue defects in 12 reconstructive cases. Such regenerated tissues survive at least 3 years after burying. Modification to the technique to avoid visible edges are being developed.
authors.affiliation: Springfield Hospital, Chelmsford, Essex CM1 7GU, UK. j.frame@btinternet.com
authors.forename: J D
authors.initials: JD
authors.lastname: Frame
authors.forename: J E
authors.initials: JE
authors.lastname: Frame
mesh_terms: D000328:Adult; D002648:Child; D002809:Chondroitin Sulfates; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016462:Mammaplasty / Q000379:methods*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000293:injuries / Q000601:surgery; D011045:Poland Syndrome / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration; D000070599:Shoulder Injuries; D012785:Shoulder Joint / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen