title: The occurrence of congenital heart defects in an inbred herd of pigs in Australia.
abstract: OBJECTIVE
  To report on the first case of congenital heart defects in pigs in Australia.
  
  
  METHODS
  Retrospective analysis of case records from an inbred herd of "Westran" pigs at the University of Sydney, between January 2001 and December 2004. Detailed gross and histological examination of 15 hearts from pigs that had died or were euthanased in 2004.
  
  
  METHODS
  The necropsy records from a population of 471 pigs that had died (106 pigs) or were euthanased for research purposes (365 pigs) were analysed and the incidence of heart defects recorded, together with basic demographic data. No attempts were made to diagnose the condition in live pigs.
  
  
  RESULTS
  Congenital heart defects were diagnosed in 6.4% of pigs but this is likely to be an underestimate of the incidence of the deformity. Eighteen pigs died on the farm as a result of the defect, and 12 pigs were diagnosed with the defect as an incidental finding. The most common abnormality seen at necropsy was a sac-like dilatation on the right lateral surface of the right atrium. This was associated with secondary deformity and hypoplasia of the adjacent left ventricle, interventricular region and part of the right ventricle. All hearts showed atrial septal defects of varying size.
  
  
  CONCLUSIONS
  This is the first reported case of congenital heart defects in pigs in Australia, and one of less than five reported cases of atrial septal defects in pigs in the world. The authors conclude that there may be an element of genetic predisposition to the malformation, since it has only been reported in this inbred line of pigs.
authors.affiliation: University of Sydney, Faculty of Veterinary Science, Camden, New South Wales.
authors.forename: P K
authors.initials: PK
authors.lastname: Holyoake
authors.forename: J
authors.initials: J
authors.lastname: Stevenson
authors.forename: C
authors.initials: C
authors.lastname: Moran
authors.forename: R
authors.initials: R
authors.lastname: Stokes
authors.forename: E P
authors.initials: EP
authors.lastname: Kirk
authors.forename: E
authors.initials: E
authors.lastname: Sugo
authors.forename: W J
authors.initials: WJ
authors.lastname: Hawthorne
mesh_terms: D000818:Animals; D001315:Australia / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D007178:Inbreeding; D015994:Incidence; D008297:Male; D009206:Myocardium / Q000473:pathology; D012189:Retrospective Studies; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology