Minor head trauma-induced sporadic hemiplegic migraine coma.
Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene (chromosome 19p13) for familial hemiplegic migraine. Recently a gene mutation (Serine-218-Leucine) for a dramatic syndrome associated with familial hemiplegic migraine, commonly named "migraine coma", has implicated exon 5 of this gene. The occurrence of trivial head trauma, in such familial hemiplegic migraine patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Sporadic hemiplegic migraine shares a similar spectrum of clinical presentation and genetic heterogeneity. The case report presented in this article implicates the involvement of the Serine-218-Leucine mutation in the extremely rare disorder of minor head trauma-induced migraine coma. We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma.
Curtain
Robert P
RP
Genomics Research Centre, School of Medical Science, Griffith University, Gold Coast, Queensland, Australia.
Smith
Robert L
RL
Ovcaric
Mick
M
Griffiths
Lyn R
LR
D015220:Calcium Channels / Q000235:genetics*; D002675:Child, Preschool; D020207:Coma, Post-Head Injury / Q000235:genetics* / Q000473:pathology; D005260:Female; D016489:Head Injuries, Closed / Q000150:complications* / Q000473:pathology; D006801:Humans; D020325:Migraine with Aura / Q000235:genetics* / Q000473:pathology; D020864:Calcium Channels, N-Type
D015220:Calcium Channels; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type