Androgen insufficiency in women.
Androgens are directly secreted by the ovaries and adrenals in women, and androgen precursors from these glands are converted in a variety of peripheral tissues into androgens. The major androgen in women is testosterone, and its action in target tissues can be mediated through the androgen receptor or through the estrogen receptor after aromatization to estradiol. Low sexual desire that causes personal distress (or hypoactive sexual desire disorder [HSDD]) is the most common form of female sexual dysfunction, and androgen insufficiency is one cause of this problem. In addition to a low libido, the clinical construct of the female androgen insufficiency syndrome includes the presence of persistent, unexplained fatigue and a decreased sense of well-being. Although there is conflicting information about the relationship between serum testosterone concentrations and sexual desire, multiple randomized, double-blind, placebo-controlled treatment trials have demonstrated that testosterone improves libido significantly more than placebo. Doses that provide physiologic to slightly supraphysiologic serum free or bioavailable testosterone concentrations are safe and associated with only mild androgenic side effects of acne and hirsutism. Oral, but not parenteral or transdermal, testosterone may decrease high-density lipoprotein cholesterol. At present, no testosterone preparation has been approved by the FDA for the treatment of low sexual desire (HSDD), so all such therapy is considered to be off-label use at this time.
Braunstein
Glenn D
GD
Department of Medicine, Cedars-Sinai Medical Center, The David Geffen School of Medicine at UCLA, Room 2119 Plaza Level, North Tower, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. braunstein@cshs.org
D000728:Androgens / Q000172:deficiency* / Q000502:physiology; D002986:Clinical Trials as Topic; D004339:Drug Compounding; D004341:Drug Evaluation; D004345:Drug Industry / Q000941:ethics; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D013223:Statistics as Topic; D013577:Syndrome; D013739:Testosterone / Q000502:physiology / Q000627:therapeutic use; D016896:Treatment Outcome; D014930:Women
D000728:Androgens; D013739:Testosterone