title: Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction.
abstract: OBJECTIVE
  The prototypic long pentraxin pentraxin 3 is a new candidate marker for inflammatory conditions reflecting the involvement of the vascular bed. Endothelial dysfunction is a prominent feature of preeclampsia as a result of excessive maternal systemic inflammation. We investigated pentraxin 3 levels in preeclampsia and intrauterine growth restriction, pregnancy conditions related to altered placentation.
  
  
  METHODS
  We cross-sectionally studied nonpregnant women (n = 20); normal pregnancies in the first (n = 8), second (n = 10), and third (n = 26) trimester of pregnancy; 20 pregnancies complicated by preeclampsia; and 16 pregnancies complicated by intrauterine growth restriction. Maternal plasma samples were analyzed and pentraxin 3 determined by enzyme-linked immunosorbent assay. Pattern and site of placental expression of pentraxin 3 were studied by immunohistochemistry.
  
  
  RESULTS
  In normal pregnancies pentraxin 3 concentrations were significantly higher than nonpregnant women and did not change among the 3 trimesters. Significantly higher levels of pentraxin 3 were found in preeclampsia (median values 13.8 versus 2.2 ng/mL; P < .001), compared with normal pregnancies. Intrauterine growth restriction pregnancies showed intermediate levels between normal and preeclamptic patients, but this difference was not significant, compared with normal pregnancies (median values 3.9 versus 2.2 ng/mL). No significant difference of pentraxin 3 levels was found between mild and severe preeclampsia.
  
  
  CONCLUSIONS
  Elevated maternal plasma levels of pentraxin 3 in preeclamptic versus normal pregnancies could represent a marker of altered endothelial function, typical of preeclampsia.
authors.affiliation: Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Milan, Italy. Irene.Cetin@unimi.it
authors.forename: Irene
authors.initials: I
authors.lastname: Cetin
authors.forename: Veronica
authors.initials: V
authors.lastname: Cozzi
authors.forename: Fabio
authors.initials: F
authors.lastname: Pasqualini
authors.forename: Manuela
authors.initials: M
authors.lastname: Nebuloni
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.forename: Luca
authors.initials: L
authors.lastname: Vago
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pardi
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012720:Severity of Illness Index; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins