title: Prophylaxis and treatment of implant-related infections by local application of antibiotics.
abstract: Despite the improvement in surgical technique and implant design in orthopedic and trauma surgery, implant-related infections are still a challenging problem for surgeons. The use of local prophylaxis to avoid infection, such as antibiotic-loaded cement in arthroplasty, gentamicin PMMA beads and gentamicin-collagen sponge in trauma surgery, and antibacterial coating of metal implants, is discussed in the first part of this article. The second part discusses the role of local antibiotics such as gentamicin PMMA beads, and gentamicin-collagen and antibiotic-loaded cement spacers in treating implant-related infections.
authors.affiliation: Klinik für Unfall- und Wiederherstellungschirurgie, Berufsgenossenschaftliche Kliniken Bergmannstrost, Halle/Saale, Germany. michael.diefenbeck@bergmannstrost.com
authors.forename: Michael
authors.initials: M
authors.lastname: Diefenbeck
authors.forename: Thomas
authors.initials: T
authors.lastname: Mückley
authors.forename: Gunther O
authors.initials: GO
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000295:instrumentation / Q000379:methods; D001424:Bacterial Infections / Q000188:drug therapy*; D001843:Bone Cements / Q000627:therapeutic use; D020099:Coated Materials, Biocompatible; D004867:Equipment Design; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D019637:Orthopedic Procedures / Q000295:instrumentation*; D019736:Prostheses and Implants; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001843:Bone Cements; D020099:Coated Materials, Biocompatible; D005839:Gentamicins