Infantile pyknocytosis: a cause of haemolytic anaemia of the newborn.
This study defined the incidence, clinical and haematological characteristics of infantile pyknocytosis in a monocentric retrospective study of 149 blood samples referred for unexplained neonatal haemolytic anaemia. Pyknocytosis was diagnosed in 14 patients (9.4%). All patients had neonatal jaundice and severe anaemia (mean nadir haemoglobin: 6.8 g/dl) at a mean age of 21 d. The percentage of pyknocytes was 4-23%. Packed red blood cell transfusions were needed in 11 of 14 patients. Haemoglobin levels reached normal values within a mean time of 4 months. Infantile pyknocytosis is an unusual cause of neonatal haemolytic anaemia, which requires careful examination of blood smears.
Eyssette-Guerreau
Stéphanie
S
Service de Pédiatrie générale, Hôpital de Bicêtre, APHP, Le Kremlin Bicêtre, France.
Bader-Meunier
Brigitte
B
Garcon
Loïc
L
Guitton
C
C
Cynober
Thérèse
T
D000743:Anemia, Hemolytic / Q000097:blood*; D004913:Erythrocytes, Abnormal; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood; D008297:Male; D012189:Retrospective Studies
D006454:Hemoglobins