Comparative in vitro efficacies of various catheter lock solutions.
MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.
Sherertz
Robert J
RJ
Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27517, USA. sherertz@wfubmc.edu
Boger
Michael S
MS
Collins
Casey A
CA
Mason
Lori
L
Raad
Issam I
II
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000925:Anticoagulants / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002404:Catheterization / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D004364:Pharmaceutical Preparations; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012293:Rifampin / Q000494:pharmacology; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000925:Anticoagulants; D004364:Pharmaceutical Preparations; D012996:Solutions; D013829:Thiadiazines; D013654:Taurine; D000431:Ethanol; D002939:Ciprofloxacin; D014640:Vancomycin; C012566:taurolidine; D004492:Edetic Acid; D008911:Minocycline; D012293:Rifampin