Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.
Tomas
D
D
Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia. dtomas@kbsm.hr
Ulamec
M
M
Hudolin
T
T
Bulimbasić
S
S
Belicza
M
M
Kruslin
B
B
D000199:Actins / Q000378:metabolism; D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D016022:Case-Control Studies; D003893:Desmin / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009379:Neoplasms, Muscle Tissue / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D019063:Tenascin / Q000378:metabolism*; D016896:Treatment Outcome; D014746:Vimentin / Q000378:metabolism
D000199:Actins; D014408:Biomarkers, Tumor; D003893:Desmin; D007797:Laminin; D019063:Tenascin; D014746:Vimentin