Two-step selection of mRNAs in initiation of protein synthesis.
In a recent issue of Molecular Cell, Studer and Joseph (2006) clarified the molecular basis of the "standby model" and demonstrated how two-step binding of mRNAs to the small ribosomal subunit depends on initiator tRNA and initiation factors, with far-reaching implications for posttranscriptional regulation of gene expression.
Hauryliuk
Vasili
V
Department of Cell and Molecular Biology, Uppsala Universitet, BMC, S-75124 Uppsala, Sweden.
Ehrenberg
Mans
M
D031541:Fluorescence Resonance Energy Transfer; D005786:Gene Expression Regulation; D007700:Kinetics; D009690:Nucleic Acid Conformation; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D012335:RNA, Ribosomal