Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial.
OBJECTIVE
To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate (MTX) in medical management of unruptured ectopic pregnancies.


METHODS
Prospective randomized clinical trial.


METHODS
Tertiary university hospital.


METHODS
The study population included 108 patients presenting with unruptured ectopic pregnancies who fulfilled the criteria for medical management.


METHODS
A single dose (study group) or multiple doses (control group) of MTX were administered IM.


METHODS
Success rate of medical management in each group.


RESULTS
Of the 54 patients on the single-dose protocol, treatment was considered successful in 48 patients (88.9%). Of the 54 patients on the multiple-dose protocol, 50 participants responded to the treatment (92.6%). The difference between success rates in the two groups was not statistically significant (P=.7; odds ratio 0.64; 95% confidence interval 0.17-2.4). In the single-dose and multiple-dose groups, 15 (27.8%) and 20 (37%) patients, respectively, had complications (P=.3).


CONCLUSIONS
The results of our study showed that single-dose treatment with MTX could be as successful as multiple doses. The incidence of complications did not differ between the two groups. It appears that single-dose treatment could be the first line of treatment in selected patients.
Alleyassin
Ashraf
A
Department of Obstetrics and Gynecology, Vali-e-asr Reproductive Health Research Center, Dr. Shariati Hospital, Tehran University of Medical Science, Tehran, Iran.
Khademi
Afsaneh
A
Aghahosseini
Marzieh
M
Safdarian
Leili
L
Badenoosh
Bita
B
Hamed
Ehsan Akbari
EA
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000453:epidemiology* / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
D008727:Methotrexate