Effect of glycodelin on the production of vascular endothelial growth factor in cumulus cells.
Glycodelin modulates vascular endothelial growth factor (VEGF) production in cumulus cells in vitro. Patients with normal gonadotropin responses who were undergoing IVF demonstrated increased VEGF production to glycodelin, whereas poor responders had a decreased response to glycodelin.
Hayes
Ellen C
EC
Center for Reproductive Medicine and Fertility, Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia, USA.
Dominguez
Celia E
CE
Voelkel
Steven
S
Song
Mingqing
M
Shanti
Aida S
AS
Murphy
Ana A
AA
D000328:Adult; D016022:Case-Control Studies; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000008:administration & dosage*; D006801:Humans; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism*; D011257:Pregnancy Proteins / Q000008:administration & dosage*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A