CD24 Ala/Val polymorphism and multiple sclerosis.
CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1,180 cases and 1,168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms.
Goris
An
A
Department of Clinical Neurosciences, Neurology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. ag441@medschl.cam.ac.uk
Maranian
Melanie
M
Walton
Amie
A
Yeo
Tai Wai
TW
Ban
Maria
M
Gray
Julia
J
Dubois
Bénédicte
B
Compston
Alastair
A
Sawcer
Stephen
S
D000409:Alanine / Q000235:genetics*; D051927:CD24 Antigen / Q000235:genetics*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects / Q000276:immunology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000627:therapeutic use; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D019707:Receptors, Chemokine / Q000096:biosynthesis; D014633:Valine / Q000235:genetics*
D051927:CD24 Antigen; D019707:Receptors, Chemokine; D008942:Mitoxantrone; D014633:Valine; D000409:Alanine