Brain cancer stem-like cells.
Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Moreover, many tumours and cancer cell lines express stem cell markers, including adenosine triphosphate (ATP)-binding cassette transporters, by which the cells pump out specific fluorescent dyes as well as anti-cancer drugs, suggesting either that cancer cells resemble stem cells or that cancers contain stem-like cells. Using the common characteristics of brain tumour cells and neural stem cells, several research groups have succeeded in identifying stem-like cells (cancer stem-like cells) in brain tumours and brain cancer cell lines. The purified cancer stem-like cells, but not the other cancer cells, self-renew and form tumours when transplanted in vivo. Thus, cancer stem-like cells in brain tumours might be a crucial target for anti-brain tumour therapy.
Kondo
Toru
T
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK. tkondo@cdb.riken.jp
D001932:Brain Neoplasms / Q000473:pathology*; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*