Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules.
Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and He(q+) with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.
Alvarado
Fresia
F
KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747AA, Groningen, The Netherlands. alvarado@kvi.nl
Bari
Sadia
S
Hoekstra
Ronnie
R
Schlathölter
Thomas
T
D004249:DNA Damage; D053938:DNA Fragmentation; D003627:Data Interpretation, Statistical; D003855:Deoxyribose / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D007477:Ions; D008956:Models, Chemical; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D007477:Ions; D003855:Deoxyribose