title: Organization of frequency spectra of atrial fibrillation: relevance to radiofrequency catheter ablation.
abstract: BACKGROUND
  We hypothesized that the frequency spectra of fibrillatory electrograms may reflect the complexity of activities perpetuating atrial fibrillation (AF). To test this hypothesis, we evaluated the frequency spectra in patients with paroxysmal AF in relation to catheter ablation.
  
  
  RESULTS
  This study comprised two protocols: 25 patients undergoing pulmonary vein (PV) isolation in protocol I, and 20 patients undergoing mitral isthmus linear ablation after PV isolation in protocol II. The mean of dominant frequency (DF) and organization index (the ratio of the area under the DF and its harmonics to the total power) were determined from 32-second recordings in the coronary sinus. In protocol I, a PV was considered "driver" of AF if isolation of the PV resulted in termination or slowing of AF (decrease in DF by > or =0.25 Hz). Twenty-one patients had AF termination during four PV isolation. Among these 21 patients, 13 patients with single driving PV showed significantly higher baseline organization index than eight patients with multiple driving PVs (0.45 +/- 0.08 vs 0.35 +/- 0.07, P = 0.009). Patients with multiple driving PVs showed a significant increase in the organization index to 0.45 +/- 0.11 (P < 0.05) after isolation of the initial driving PVs. In protocol II, the baseline organization index was significantly higher in seven patients who had termination of AF during mitral isthmus ablation than 13 patients who did not (0.50 +/- 0.10 vs 0.38 +/- 0.07, P < 0.008). The baseline DF was not associated with outcomes of ablation in both protocols.
  
  
  CONCLUSIONS
  A higher organization index of atrial electrograms is associated with termination of AF during limited ablation. This parameter may be useful to anticipate the extent of ablation.
authors.affiliation: Cardiologic Hospital of Haut-Lévêque, University Victor Segalen Bordeaux 2, Avenue de Magellan, 33604 Bordeaux-Pessac, France. yoshihide.takahashi@wanadoo.fr
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Prashanthan
authors.initials: P
authors.lastname: Sanders
authors.forename: Pierre
authors.initials: P
authors.lastname: Jaïs
authors.forename: Mélèze
authors.initials: M
authors.lastname: Hocini
authors.forename: Rémi
authors.initials: R
authors.lastname: Dubois
authors.forename: Martin
authors.initials: M
authors.lastname: Rotter
authors.forename: Thomas
authors.initials: T
authors.lastname: Rostock
authors.forename: Chrishan J
authors.initials: CJ
authors.lastname: Nalliah
authors.forename: Frédéric
authors.initials: F
authors.lastname: Sacher
authors.forename: Jacques
authors.initials: J
authors.lastname: Clémenty
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome