title: A toxicokinetic model for the carry-over of dioxins and PCBs from feed and soil to eggs.
abstract: A mathematical model for the kinetics of carry-over of dioxins and dioxin-like PCBs from feed mixed with contaminated oil to eggs has been developed. This model incorporates uptake of the compounds over the gut wall and their subsequent transport by blood, distribution over the body, hepatic metabolism and excretion through egg yolk fat. The model is analysed with respect to the possibility of identifying as yet unknown model parameters by fitting these to the experimental data. The model was fitted to the experimental data on the carry-over from feed to eggs. The calibrated model was applied to calculate the steady-state concentrations in eggs which were compared to European Maximum Residue Levels for dioxins in feed and eggs, showing that these limits do not match. The feed limit of 0.75 ng TEQ/kg should be reduced to about 0.17 ng TEQ/kg in order to guarantee egg levels below the residue limit of 3 pg TEQ/g fat. Experimental results of carry-over from contaminated soil were used to estimate the absorption of dioxin-like compounds from soils as compared to the absorption from feed, resulting in a value around 40 to 60% absorption from soil as compared to around 90% absorption from feed.
authors.affiliation: RIVM National Institute of Public Health and the Environment, Bilthoven, The Netherlands. jan.van.eijkeren@rivm.nl
authors.forename: J C H
authors.initials: JC
authors.lastname: Van Eijkeren
authors.forename: M J
authors.initials: MJ
authors.lastname: Zeilmaker
authors.forename: C A
authors.initials: CA
authors.lastname: Kan
authors.forename: W A
authors.initials: WA
authors.lastname: Traag
authors.forename: L A P
authors.initials: LA
authors.lastname: Hoogenboom
mesh_terms: D000042:Absorption; D000273:Adipose Tissue / Q000378:metabolism; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002645:Chickens; D004147:Dioxins / Q000097:blood / Q000493:pharmacokinetics*; D004530:Egg Yolk / Q000378:metabolism; D004531:Eggs / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008452:Maximum Allowable Concentration; D008954:Models, Biological; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000493:pharmacokinetics*; D012989:Soil Pollutants / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D004147:Dioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls