Ultrastructure of the trabecular meshwork in secondary glaucoma eyes after intravitreal triamcinolone acetonide.
OBJECTIVE
To study the histology of the trabecular meshwork of eyes with glaucoma by intravitreal injection of triamcinolone acetonide (TA).


METHODS
Two cases report.


METHODS
A 68-year-old Japanese man with branch retinal vein occlusion and a 48-year-old Japanese woman with uveitis were treated by cataract surgery, intraocular lens implantation, and TA-assisted pars plana vitrectomy. At the end of surgery, TA suspension (4 mg) was intravitreously injected. During the follow-up period, the intraocular pressure (IOP) of the patients increased over 30 mm Hg even with full medication. Trabeculectomy was performed at 4 months after TA injection in case 1 and at 6 months in case 2, and intraocular pressure returned to the normal range in both cases. Light and electron microscopic studies of the resected trabecular tissue were carried out.


RESULTS
The histology showed minimal deposition of extracellular matrix in the trabecular meshwork in case 1. Case 2 showed the beginnings of deposition of extracellular matrix including fingerprintlike material in the trabecular meshwork with decreased intertrabecular spaces.


CONCLUSIONS
The ultrastructural changes in the trabecular meshwork of eyes with glaucoma after treatment with intravitreal TA might resemble those with glaucoma after topical corticosteroid treatment.
Kubota
Toshiaki
T
Department of Ophthalmology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Okabe
Hakuoh
H
Hisatomi
Toshio
T
Yamakiri
Keita
K
Sakamoto
Taiji
T
Tawara
Akihiko
A
D005109:Extracellular Matrix / Q000648:ultrastructure; D005260:Female; D005901:Glaucoma / Q000139:chemically induced / Q000473:pathology*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000188:drug therapy; D014129:Trabecular Meshwork / Q000187:drug effects / Q000648:ultrastructure*; D014130:Trabeculectomy; D014222:Triamcinolone Acetonide / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy; D014822:Vitreous Body
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide