title: Volume measurement by CARTO compared with cardiac magnetic resonance.
abstract: OBJECTIVE
  The CARTO electrophysiological mapping system has demonstrated accurate results for end-diastolic ventricular volumes in casts and animals. However, in humans, a comparison with cardiac magnetic resonance (CMR), the non-invasive gold standard for volumetric analysis, has not yet been performed.
  
  
  RESULTS
  A total of 34 (29 male) heart failure patients (NYHA class III/IV) underwent an electrophysiological mapping procedure with the CARTO system in the left ventricle (LV) (n = 34) and right ventricle (RV) (n = 12) and CMR for RV and LV end-diastolic volume (RVEDV and LVEDV) measurements another day. Mean LVEDV was comparable between CMR and CARTO (328 +/- 95 and 320 +/- 92 mL, respectively; P = NS), whereas RV volumes measured by CARTO were larger (CMR 140 +/- 48 vs. CARTO 176 +/- 47 mL; P < 0.01). Overall, we found a good correlation between CMR and CARTO measurements for both chambers; however, the Bland-Altman analysis showed a non-interchangeability of these methods. Measurement differences were independent of chamber size, but significantly affected by the number of acquired mapping points.
  
  
  CONCLUSIONS
  Although CMR and CARTO showed a good correlation in the measurement of RVEDV and LVEDV in a group of heart failure patients, the clinical interchangeability of the two methods may be questioned.
authors.affiliation: Department of Cardiology, Otto-von-Guericke-University Leipziger Strasse 44, D-39120 Magdeburg, Germany. frank.grothues@medizin.uni-magdeburg.de
authors.forename: F
authors.initials: F
authors.lastname: Grothues
authors.forename: O
authors.initials: O
authors.lastname: Wolfram
authors.forename: C
authors.initials: C
authors.lastname: Fantoni
authors.forename: H
authors.initials: H
authors.lastname: Boenigk
authors.forename: A
authors.initials: A
authors.lastname: Götte
authors.forename: C
authors.initials: C
authors.lastname: Tempelmann
authors.forename: H U
authors.initials: HU
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Auricchio
mesh_terms: D022062:Electrophysiologic Techniques, Cardiac / Q000295:instrumentation*; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000295:instrumentation; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine