Optic pathway glioma: outcome and prognostic factors in a surgical series.
OBJECTIVE
The goals of this study were to evaluate the surgical outcomes of optic pathway glioma (OPG) and to analyze the prognostic factors related to the progression-free survival.


METHODS
A retrospective review was conducted on 33 patients who underwent surgery for OPG; these included 15 male and 18 female patients with a mean age of 8.3 years. The mean duration of follow-up was 52 months.


CONCLUSIONS
The preservation rate of ipsilateral vision was 25%, while that of contralateral vision was 83% (P<0.001). There was no remarkable endocrine improvement after surgery. The overall and progression-free survival rates at 5 years were 93.6 and 52.4%, respectively. In our study, the predictors for tumor progression were children younger than 5 years of age (p=0.023) and of female gender (p=0.022). Because of the variable course of OPG, treatment policy should be optimized individually according to patient's status.
Ahn
Yong
Y
Department of Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea.
Cho
Byung-Kyu
BK
Kim
Seung-Ki
SK
Chung
You-Nam
YN
Lee
Chang Sub
CS
Kim
Il Han
IH
Yang
Sei Won
SW
Kim
Hee-Soo
HS
Kim
Hyun Jib
HJ
Jung
Hee-Won
HW
Wang
Kyu-Chang
KC
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D018572:Disease-Free Survival; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology / Q000601:surgery; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D009897:Optic Chiasm / Q000473:pathology / Q000601:surgery; D020339:Optic Nerve Glioma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate