title: Intracameral cefazolin as prophylaxis against endophthalmitis in cataract surgery.
abstract: OBJECTIVE
  To evaluate the efficacy of prophylactic intracameral cefazolin in preventing endophthalmitis in cataract surgery.
  
  
  METHODS
  Service of Ophthalmology, St. Joan Hospital, Reus, Spain.
  
  
  METHODS
  In this noncontrolled retrospective observational study, all patients had uncombined cataract surgery from January 2001 to December 2004. All cases of postoperative endophthalmitis were related. The patients were classified into 2 groups. The first (n = 3650) had surgery between January 2001 and December 2002, and the second (n = 3618) had surgery between January 2003 and December 2004; the second group received a bolus of intracameral cefazolin instilled at the end of surgery.
  
  
  RESULTS
  The rate of postoperative endophthalmitis was lower in the cases with intracameral injection at the end of surgery (0.055%) than in those without cefazolin injection (0.63%). No patients in the group with intracameral cefazoline developed corneal endothelium or retinal toxicity.
  
  
  CONCLUSIONS
  Intracameral bolus injection of cefazolin (1 mg in 0.1 mL solution) in cataract surgery demonstrated prophylactic efficacy in diminishing the rate of postoperative endophthalmitis without toxic effects on the cornea or retina.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Sant Joan de Reus, Departamento de Medicina y Cirugía, Universidad Rovira y Virgili, Reus, Spain. promero@grupsagessa.com
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero
authors.forename: Isabel
authors.initials: I
authors.lastname: Méndez
authors.forename: Merce
authors.initials: M
authors.lastname: Salvat
authors.forename: Juan
authors.initials: J
authors.lastname: Fernández
authors.forename: Matias
authors.initials: M
authors.lastname: Almena
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000302:isolation & purification; D002387:Cataract Extraction; D002437:Cefazolin / Q000009:adverse effects / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000382:microbiology / Q000517:prevention & control*; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin