title: Uterine leiomyosarcoma with osteoclast like giant cells and long standing systemic symptoms.
abstract: BACKGROUND
  The leiomyomatous type of uterine sarcoma with osteoclast-type giant cell component is a rare variant of uterine tumors with poor prognosis. The histological diagnosis of these rare tumors can be problematic and only five such tumors have been published previously.
  
  
  METHODS
  A 54-year-old woman presented with fever and weight loss for 7 months and laboratory findings suggestive of inflammation. After extensive clinical investigation, a uterine tumor was found, which was considered to be an incidental finding and was thought to be unlikely to explain the symptoms. After hysterectomy, the patient had a surprising and quick recovery with the complete relief of systemic symptoms and normalization of laboratory changes. The tumor was a dedifferentiated leiomyosarcoma with osteoclast-like giant cells and contained extensive necrosis. The patient continues to do well and is tumor-free 1 year after the operation.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of a patient being alive and disease-free 12 months after surgery with a dedifferentiated uterine leiomyosarcoma with osteoclast-like giant cells.
authors.affiliation: 2nd Department of Obstetrics and Gynecology, Semmelweis Medical University, Budapest, Hungary.
authors.forename: Kalman
authors.initials: K
authors.lastname: Patai
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Illyes
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Varbiro
authors.forename: Janos
authors.initials: J
authors.lastname: Gidai
authors.forename: Lajos
authors.initials: L
authors.lastname: Kosa
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Vajo
mesh_terms: D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*