Climbing the Greatwall to mitosis.
Greatwall kinase is a conserved regulator of mitotic entry, and new work in Xenopus egg extracts (Yu et al., 2006) shows that Greatwall is required for the positive feedback loop that removes inhibitory tyrosine phosphate from the central mitotic regulatory kinase Cdc2.
Jackson
Peter K
PK
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D051357:Cyclin-Dependent Kinase 2 / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation; D025461:Feedback, Physiological; D005260:Female; D008938:Mitosis; D008954:Models, Biological; D009865:Oocytes / Q000201:enzymology; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D014982:Xenopus laevis / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D011494:Protein Kinases; C490167:Gwl protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D051357:Cyclin-Dependent Kinase 2; D017027:Protein Tyrosine Phosphatases