Identification of a novel 120 bp allele at the TNFd microsatellite locus.
Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in the TNF region, named TNF a-e. TNFb, TNFc, TNFd, and TNFe are (GA)n repeats, whereas TNFa and TNFf are (GT)n and (CA)n repeats, respectively. The TNFd microsatellite locus maps 8-10 kb centromeric to the TNF-alpha gene, downstream to the TNF-beta gene.
Wastowski
I J
IJ
Program of Basic and Applied Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, Sp, Brazil.
Peres
N T A
NT
Simões
R T
RT
Castelli
E C
EC
Simões
A L
AL
Martinez-Rossi
N M
NM
Donadi
E A
EA
D000483:Alleles; D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000145:classification / Q000235:genetics*
D005819:Genetic Markers; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha