Serum free Fatty acids and glucose metabolism, insulin resistance in schizophrenia with chronic antipsychotics.
BACKGROUND
Weight gain and type 2 diabetes mellitus (DM) are often linked to antipsychotics treatment. The aim of the study is to investigate serum free fatty acids (FFA) levels in schizophrenic patients who received long-term antipsychotics treatment, and to explore the associations between serum FFA and fasting blood glucose, and insulin resistance.


METHODS
308 inpatients with schizophrenia who met with the criteria of DSM-IV were recruited into this study, and were divided into four groups: control subjects, single obesity, impaired glucose tolerance (IGT) and type 2 DM according to different body mass index, fasting blood glucose level and 2-hour postprandial blood glucose. Serum FFA was measured with colorimetry. Serum insulin and leptin were measured with radioimmunoassay respectively.


RESULTS
There was a significant elevation in serum FFA levels in schizophrenic patients who received long-term antipsychotics treatment, especially in single obesity, IGT, and DM groups. The elevated serum FFA was remarkably positive correlated with fasting blood glucose and insulin resistance.


CONCLUSIONS
The study suggested the elevated serum FFA in schizophrenic patients with long-term antipsychotics treatment affected the blood glucose metabolism, may have played an important role in insulin resistance and type 2 DM, and was also an important trait of metabolic syndromes.
Wang
Cong-jie
CJ
Department of Psychiatry, Huai'an No.3 Hospital, Huai'an, Jiangsu Province, China.
Zhang
Zhi-jun
ZJ
Sun
Jing
J
Zhang
Xiao-bing
XB
Mou
Xiao-dong
XD
Zhang
Xiang-rong
XR
Shang
Xiao-fang
XF
Zhang
Tai-quan
TQ
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003124:Colorimetry; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000453:epidemiology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*
D014150:Antipsychotic Agents; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020738:Leptin