Peripapillary retinal nerve fiber layer thickness variations with myopia.
OBJECTIVE
To determine the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness and myopia using optical coherence tomography (OCT).


METHODS
Prospective observational case series.


METHODS
One hundred thirty-two young males with myopia (spherical equivalent [SE], -0.50 to -14.25 diopters) underwent ophthalmic examination of one randomly selected eye. Optical coherence tomography (OCT-1, version 4.1) was performed by a single operator using circular scans concentric with the optic disc with scan diameters of 3.40 mm, 4.50 mm, and 1.75 x vertical disc diameter (VDD). For each scan diameter, mean peripapillary RNFL thickness was calculated. Statistical analysis comprised repeated-measurements analysis and Pearson correlation.


RESULTS
Mean peripapillary RNFL thickness did not correlate with SE for the 3.40-mm (r = -0.11, P = 0.22), 4.50-mm (r = -0.103, P = 0.24), or 1.75xVDD (r = -0.08, P = 0.36) OCT scan diameters. Neither did mean peripapillary RNFL thickness correlate with axial length for the 3.40-mm (r = -0.04, P = 0.62), 4.50-mm (r = 0.03, P=0.75), or 1.75xVDD (r = -0.02, P = 0.78) scan diameters. Mean peripapillary RNFL thicknesses for the 3.40-mm, 4.50-mm, and 1.75xVDD scans were 101.1+/-8.2 microm (95% confidence interval [CI], 99.4-102.8), 78.9+/-8.2 microm (95% CI, 77.5-80.3), and 97.5+/-10.9 microm (95% CI, 95.6-99.4), respectively.


CONCLUSIONS
Mean peripapillary RNFL thickness did not vary with myopic SE or axial length for any OCT scan diameter investigated. Retinal NFL thickness measurements may be a useful parameter to assess and monitor glaucoma damage in myopic subjects.
Hoh
Sek-Tien
ST
Singapore National Eye Centre & Singapore Eye Research Institute, Singapore.
Lim
Marcus C C
MC
Seah
Steve K L
SK
Lim
Albert T H
AT
Chew
Sek-Jin
SJ
Foster
Paul J
PJ
Aung
Tin
T
D000328:Adult; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009216:Myopia / Q000150:complications*; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D009900:Optic Nerve / Q000033:anatomy & histology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular