Development of drug intermediates by using direct organocatalytic multi-component reactions.
Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.
Ramachary
Dhevalapally B
DB
School of Chemistry, University of Hyderabad, India. ramsc@uohyd.ernet.in
Kishor
M
M
Reddy
G Babul
GB
D000478:Alkylation; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004095:Dihydropyridines / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D011392:Proline / Q000737:chemistry
D002264:Carboxylic Acids; D004095:Dihydropyridines; D006846:Hydrocarbons, Halogenated; D007659:Ketones; D004364:Pharmaceutical Preparations; D011392:Proline