New developmental insights from high-throughput biological analysis in Caenorhabditis elegans.
The use of Caenorhabditis elegans as a model system for understanding animal development and human disease has long been recognized as an efficient tool of discovery. Recent developments, particularly in our understanding of RNA-mediated interference and its ability to modify gene activity, have facilitated the use of C. elegans in determining gene function via high-throughput analysis. These new strategies have provided a framework that allows investigators to analyse gene function globally at the genomic level and will likely become a prototypic model for biological analysis in the post-genome era.
Labbé
J-C
JC
Institut de recherche en immunologie et en cancérologie, Universite de Montreal, Montreal, Quebec, Canada. jc.labbe@umontreal.ca
Roy
R
R
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism; D015723:Gene Library; D005804:Genes, Lethal; D005821:Genetic Techniques; D023281:Genomics / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference