title: Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation.
abstract: Increasing the upper age limit for recipients of hematopoietic stem cell transplantation (HCT) naturally has also increased the age of the corresponding related donor population. Because aging is a risk factor for malignancies, the risk of transferring preexisting malignant or premalignant hemopoietic clones in the process of HCT might be expected to increase as well. Anecdotal clinical cases of malignancies derived from donor cells in patients undergoing HCT have been published since 1971. In this article, we report 12 new cases that fit 2 different categories: (1) cases in which clones with characteristics of lymphohemopoietic malignancies were transferred from the donors to the recipients and (2) cases in which the malignant clone evolved from healthy donor cells once transplanted into the recipient. Donors in the first group were significantly older than donors in the second group. A more systematic examination of the prevalence and biology of donor malignancies would merit study.
authors.affiliation: Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. osala@fhcrc.org
authors.forename: Olga
authors.initials: O
authors.lastname: Sala-Torra
authors.forename: Colleen
authors.initials: C
authors.lastname: Hanna
authors.forename: Michael R
authors.initials: MR
authors.lastname: Loken
authors.forename: Mary E D
authors.initials: ME
authors.lastname: Flowers
authors.forename: Michael
authors.initials: M
authors.lastname: Maris
authors.forename: Paula A
authors.initials: PA
authors.lastname: Ladne
authors.forename: James R
authors.initials: JR
authors.lastname: Mason
authors.forename: David
authors.initials: D
authors.lastname: Senitzer
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodriguez
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
authors.forename: H Joachim
authors.initials: HJ
authors.lastname: Deeg
authors.forename: Jerald P
authors.initials: JP
authors.lastname: Radich
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002471:Cell Transformation, Neoplastic; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells / Q000166:cytology / Q000637:transplantation; D005260:Female; D005819:Genetic Markers; D019337:Hematologic Neoplasms / Q000209:etiology*; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology / Q000637:transplantation; D016609:Neoplasms, Second Primary / Q000209:etiology; D014411:Neoplastic Stem Cells / Q000637:transplantation*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000009:adverse effects*
chemical_list: D005819:Genetic Markers