title: Natural killer-like T cell lymphoma of the small intestine: report of a case.
abstract: We report the case of a 77-year-old Japanese man with natural killer (NK)-like T cell lymphoma of the small intestine diagnosed after an emergency laparotomy for perforated peritonitis. Immunohistochemical staining of the tumor showed that the patient had CD3+ CD8+ CD30- CD56+ CD68- CD79a- UCHL-1+ EMA- LMP-1 NK-like T cell lymphoma. The patient had a history of hepatocellular carcinoma (HCC) and was also diagnosed with T cell non-Hodgkin's lymphoma associated with T cell receptor (TCR) reconstruction in the Jgamma chain. Intestinal T cell lymphoma is uncommon and very few cases of CD56+ T cell lymphoma, otherwise known as NK-like T cell lymphoma, have been reported. The patient did not have a history of gluten-sensitive enteropathy (celiac disease). Multiple lesions appeared within months after the initial operation and his condition deteriorated rapidly. We think that this patient probably had NK-type granular lymphocyte-proliferative disorder (NK-GLPD) because the percentage of CD16+ CD56+ cells among peripheral blood mononuclear cells was elevated, at 21%. We report this case to help elucidate the relationship between underlying digestive organ disease and the development of intestinal NK-like T cell lymphoma. An accumulation of other such cases is needed to determine the etiology of this disease.
authors.affiliation: Digestive Disease Center, Showa University Nothern Yokohama City Hospital, 35-1 Chigasaki-chou, Yokohmama, Kanagawa, 224-8503, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Deguchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: Shungo
authors.initials: S
authors.lastname: Endo
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D007694:Killer Cells, Natural; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000473:pathology; D008297:Male