Increase of oxidized/total coenzyme Q-10 ratio in cerebrospinal fluid in patients with Parkinson's disease.
The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3+/-17.9%) compared to the normal control group (68.2+/-20.4%) (p<0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development.
Isobe
Chiaki
C
Department of Neurology Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-0805, Japan. chiso@apost.plala.or.jp
Murata
Takahiko
T
Sato
Chigumi
C
Terayama
Yasuo
Y
D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D012016:Reference Values; D018709:Statistics, Nonparametric; D014451:Ubiquinone / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D014451:Ubiquinone