title: Extended treatment with bupropion SR for cigarette smoking cessation.
abstract: The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking cessation. Adult smokers (N = 362) received open-label treatment (11 weeks) that combined relapse prevention training, bupropion SR, and nicotine patch followed by extended treatment (14 weeks) with bupropion SR or matching placebo. Abstinence percentages were relatively high (week 11: 52%; week 25: bupropion, 42%; placebo, 38%; week 52: bupropion, 33%; placebo, 34%), but bupropion SR did not surpass placebo. Gender and baseline craving level were identified as significant, independent moderators of treatment response. Men were more likely to abstain than women (week 11: 59% vs. 43%, p = .001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest.
authors.affiliation: Stanford University School of Medicine, Stanford, CA 94305-5705, USA. jkillen@stanford.edu
authors.forename: Joel D
authors.initials: JD
authors.lastname: Killen
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Fortmann
authors.forename: Greer M
authors.initials: GM
authors.lastname: Murphy
authors.forename: Chris
authors.initials: C
authors.lastname: Hayward
authors.forename: Christina
authors.initials: C
authors.lastname: Arredondo
authors.forename: Deann
authors.initials: D
authors.lastname: Cromp
authors.forename: Maria
authors.initials: M
authors.lastname: Celio
authors.forename: Laurie
authors.initials: L
authors.lastname: Abe
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Alan F
authors.initials: AF
authors.lastname: Schatzberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016642:Bupropion / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*
chemical_list: D003692:Delayed-Action Preparations; D016642:Bupropion