title: The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers.
abstract: OBJECTIVE
  To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers.
  
  
  METHODS
  Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs.
  
  
  RESULTS
  OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs.
  
  
  CONCLUSIONS
  OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
authors.affiliation: Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. yongqianshu@hotmail.com
authors.forename: Yong-Qian
authors.initials: YQ
authors.lastname: Shu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Gu
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000187:drug effects* / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D010844:Picibanil / Q000494:pharmacology*
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D010844:Picibanil