title: Oral, post-oral and genetic interactions in sweet appetite.
abstract: Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite.
authors.affiliation: Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, USA. Asclafani@gc.cuny.edu
authors.forename: Anthony
authors.initials: A
authors.lastname: Sclafani
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000235:genetics / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009055:Mouth / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D012054:Reinforcement, Psychology; D013045:Species Specificity; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013649:Taste / Q000235:genetics / Q000502:physiology*
chemical_list: D043562:Receptors, G-Protein-Coupled; D013549:Sweetening Agents; C431926:taste receptors, type 1; D013395:Sucrose