[Preventive effect of genistein on malignant transformation of oral leukoplakia].
OBJECTIVE
To investigate the preventive effect of genistein on the malignant transformation of oral leukoplakia in hamster cheek pouch.


METHODS
Sixty male Syrian golden hamsters were randomly divided into 4 groups, with two of 20 and two of 10. DMBA solution (0.5% in acetone) was applied topically to the left cheek pouch of male Syrian golden hamsters in group A and B, while animals in group C were painted with acetone, 3 times a week for 6 weeks. For the next 12 weeks, animals in group B received genistein (10 mg.kg(-1).d(-1)) daily by gavage; animals in group A and C received same volume of saline; animals in group D serving as blank control. At the end of the experiment, animals were sacrificed and tissue samples were collected for histopathological examination.


RESULTS
No significant differences in the tumor latency and tumor incidence were observed between the control and genistein treated group.


CONCLUSIONS
No inhibitory effect of genistein on the transformation of oral leukoplakia was observed in hamster.
Yang
Ya
Y
Department of Oral Medicine, School of Stamotology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Zhou
Zeng-tong
ZT
Ge
Jian-ping
JP
D000818:Animals; D006224:Cricetinae; D019833:Genistein / Q000494:pharmacology* / Q000627:therapeutic use; D007972:Leukoplakia, Oral / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology / Q000517:prevention & control*
D019833:Genistein