Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.
Oh
Sei-Ryang
SR
Innunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, South Korea.
Lee
Mee Young
MY
Ahn
Kyungseop
K
Park
Bo-Young
BY
Kwon
Ok-Kyuoung
OK
Joung
Hyouk
H
Lee
Joongku
J
Kim
Doo-Young
DY
Lee
Sangku
S
Kim
Joo Heon
JH
Lee
Hyeong-Kyu
HK
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology / Q000276:immunology; D003521:Cyclopropanes; D004195:Disease Models, Animal; D005260:Female; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007073:Immunoglobulin E / Q000032:analysis / Q000097:blood; D018793:Interleukin-13 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D057888:Iridoid Glucosides; D039823:Iridoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D009093:Mucus / Q000378:metabolism; D010047:Ovalbumin / Q000276:immunology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D011014:Pneumonia / Q000139:chemically induced / Q000188:drug therapy*; D011657:Pulmonary Eosinophilia / Q000473:pathology; D011804:Quinolines / Q000494:pharmacology; D013440:Sulfides; D032264:Veronica / Q000737:chemistry*
D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D005960:Glucosides; D018793:Interleukin-13; D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; D011804:Quinolines; D013440:Sulfides; C512483:verproside; D016210:Methacholine Chloride; D015847:Interleukin-4; D007073:Immunoglobulin E; D010047:Ovalbumin; C093875:montelukast