title: 7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.
abstract: We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
authors.affiliation: Division of Microbiology, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany.
authors.forename: Magally
authors.initials: M
authors.lastname: Romero-Tabarez
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
authors.forename: Marita
authors.initials: M
authors.lastname: Sylla
authors.forename: Heinrich
authors.initials: H
authors.lastname: Lünsdorf
authors.forename: Susanne
authors.initials: S
authors.lastname: Häussler
authors.forename: Dwi A
authors.initials: DA
authors.lastname: Santosa
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Timmis
authors.forename: Gabriella
authors.initials: G
authors.lastname: Molinari
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000633:toxicity; D001412:Bacillus subtilis / Q000737:chemistry*; D016956:Burkholderia cepacia / Q000187:drug effects* / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D016983:Enterococcus / Q000187:drug effects*; D016984:Enterococcus faecium / Q000187:drug effects / Q000648:ultrastructure; D014644:Genetic Variation; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D007739:L Cells; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D016106:Methicillin Resistance; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure; D020713:Vancomycin Resistance
chemical_list: C510737:7-O-malonyl macrolactin A; D000900:Anti-Bacterial Agents; D018942:Macrolides; C453562:macrolactin A