Effect of processing variables on micro particulate system of aceclofenac.
Microparticulate systems of aceclofenac were prepared by modified solvent evaporation method using different variables such as polymer (cellulose acetate): drug ratios (1:9, 1:6, 1:3, and 1:1), agitation speeds (500-1,500 rpm) and stirring time (5-15 min). The effects of processing variables were evaluated by microparticle size and entrapment efficiency. The average microparticle size increases from 80.2+/-1.45 to 97.3+/-2.06 microm with increase in the polymer concentration while reduces with increase in agitation speed and stirring time; and at the higher speed gives irregular shape of particles. The highest entrapment efficiency, size uniformity, angle of repose (23.6+/-0.3 degree) and compressibility index (13.8+/-0.7%) of microparticles were found with 1:6 (polymer: drug ratio), at 1,000 rpm and 10 min stirring time among all microparticles. The in-vitro drug release study was carried out with prepared microcapsules (AC-1 to AC-4) of various polymer concentrations and optimized processing variables and compared with conventional and SR tablets. The conventional tablet and SR tablet releases maximum drug within 3 and 6h respectively while microparticulate system releases more than 12h. All formulations followed first order release kinetic and diffusion controlled drug release.
Dashora
Kamlesh
K
Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492 010, India.
Saraf
S
S
Saraf
Swarnlata
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D012212:Rheology; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004008:Diclofenac; C005062:acetylcellulose; D002482:Cellulose; C056498:aceclofenac