title: Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor.
abstract: Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.
authors.affiliation: MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II, Singapore 117528.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Kia-Ngee
authors.initials: KN
authors.lastname: Low
authors.forename: Robert P
authors.initials: RP
authors.lastname: Glover
authors.forename: Sharon C
authors.initials: SC
authors.lastname: Crasta
authors.forename: Siewbee
authors.initials: S
authors.lastname: Ng
authors.forename: Antony D
authors.initials: AD
authors.lastname: Buss
authors.forename: Mark S
authors.initials: MS
authors.lastname: Butler
mesh_terms: D029759:Calophyllum / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors*; D012846:Singapore; D014407:Tumor Cells, Cultured
chemical_list: D011965:Receptors, Glucocorticoid; C511037:sundaicumone A; C511038:sundaicumone B; D010696:Phloroglucinol