Comparative toxicity of fluoranthene and pentachlorobenzene to three freshwater invertebrates.
This study examined the temporal component of pentachlorobenzene lethal body residues among three freshwater invertebrates. Also, using previous fluoranthene data allowed a more detailed examination of the role of biotransformation in lethal body residues and comparisons of lethal residues across chemical classes. Time-dependent toxicity of fluoranthene and pentachlorobenzene were compared among Hyalella azteca, Chironomus tentans, and Diporeia spp. Lethal body residues required for 50% mortality (LR50) were not constant and decreased with exposure time for all species. Fluoranthene was most toxic to C. tentans with LR50 values of 0.38 micromol x g(-1) at 2 d to 0.15 micromol x g(-1) at 10 d and least toxic to Diporeia spp. with values of 9.97 micromol x g(-1) at 10 d to 3.67 micromol x g(-1) at 28 d. The LR50 values for H. azteca were intermediate and ranged from 2.25 micromol x g(-1) at 5 d to 0.56 micromol x g(-1) at 28 d. Pentachlorobenzene LR50 values were less variable among species and ranged from 1.20 micromol x g(-1) at 4 d to 0.81 micromol x g(-1) at 10 d for C. tentans, 5.0 micromol x g(-1) at 20 d and 2.75 micromol x g(-1) at 28 d for Diporeia spp., and 1.51 micromol x g(-1) at 4 d and 0.71 micromol x g(-1) at 28 d for H. azteca. When LR50 values for fluoranthene and pentachlorobenzene were compared at steady state, the lethal residues for the amphipod species were within the range expected for nonpolar narcotic chemicals (anesthetics); however, C. tentans was more sensitive to fluoranthene than pentachlorobenzene, confirming our previous hypothesis that biotransformation of fluoranthene likely produces a metabolite(s) acting by some specific mechanism of action. The information collected from this study allows a greater understanding of residue-response relationships, specifically relative species sensitivities.
Schuler
Lance J
LJ
Fisheries and Illinois Aquaculture Center, Department of Zoology, Southern Illinois University at Carbondale, Carbondale, Illinois 62901-6511, USA.
Landrum
Peter F
PF
Lydy
Michael J
MJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002722:Chlorobenzenes / Q000378:metabolism / Q000633:toxicity*; D003445:Crustacea / Q000187:drug effects*; D004175:Diptera / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000378:metabolism / Q000633:toxicity*; D005618:Fresh Water; D007700:Kinetics; D007928:Lethal Dose 50
D002722:Chlorobenzenes; D005449:Fluorenes; C007738:fluoranthene; C003060:pentachlorobenzene