title: VEGF receptor signalling - in control of vascular function.
abstract: Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.
authors.affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldv. 20, 751 85 Uppsala, Sweden.
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Olsson
authors.forename: Anna
authors.initials: A
authors.lastname: Dimberg
authors.forename: Johan
authors.initials: J
authors.lastname: Kreuger
authors.forename: Lena
authors.initials: L
authors.lastname: Claesson-Welsh
mesh_terms: D000818:Animals; D047108:Embryonic Development; D006801:Humans; D018919:Neovascularization, Physiologic; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
chemical_list: D042442:Vascular Endothelial Growth Factors; D040262:Receptors, Vascular Endothelial Growth Factor