The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.
Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B(*)17 was associated with a 26-fold reduction in plasma virus concentrations (P<0.001). Mamu-B(*)17 was also enriched in a group of animals that controlled viral replication by 1,000-fold [corrected] Even after accounting for this group, Mamu-B(*)17 was associated with an eightfold reduction in plasma virus concentrations (P<0.001). Mamu-B(*)17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.
Yant
Levi J
LJ
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53711, USA.
Friedrich
Thomas C
TC
Johnson
Randall C
RC
May
Gemma E
GE
Maness
Nicholas J
NJ
Enz
Alissa M
AM
Lifson
Jeffrey D
JD
O'Connor
David H
DH
Carrington
Mary
M
Watkins
David I
DI
D000483:Alleles; D000818:Animals; D005787:Gene Frequency / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014766:Viremia / Q000276:immunology / Q000821:virology; D014779:Virus Replication / Q000276:immunology*
D015395:Histocompatibility Antigens Class I