Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens.
Three new (1-3) and five known (4-8) partially acetylated oligorhamnoside derivatives were obtained from Cleistopholis patens via high-throughput natural products chemistry procedures. The rapid structure elucidation and dereplication were performed primarily utilizing a capillary-scale NMR probe and LR-/HRESIMS spectroscopic methods. Compounds 1, 2, and 6 were found to possess significant in vitro antibacterial activity against the Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with MICs of < or =16 microg/mL. Furthermore, 2 and 6 were found to show significant in vitro antibacterial activity against an expanded panel of Gram-positive pathogens including either ATCC strains or well-characterized clinical isolates from the global SENTRY Antimicrobial Surveillance Program.
Hu
Jin-Feng
JF
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc., 11199 Sorrento Valley Road, Suite H, San Diego, CA 92121, USA. jhu@sequoiasciences.com
Garo
Eliane
E
Hough
Grayson W
GW
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Eldridge
Gary R
GR
D029061:Annonaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005681:Gabon; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D006027:Glycosides