Repair of bone defects treated with autogenous bone graft and low-power laser.
Because bone healing at the graft site is similar to a fracture repair, the purpose of the present study was to evaluate the effects of low-power laser irradiation on the repair of rat skull defects treated with autogenous bone graft. A defect measuring 3 mm in diameter was produced in the left parietal bone and filled with an autogenous bone graft obtained from the right parietal bone. The animals were divided into 3 groups of 20 rats each: nonirradiated control, irradiated with 5.1 J/cm, and irradiated with 10.2 J/cm. The laser (2.4 mW, 735 nm, 3.4 x 10 W/cm, 3-mm spot size) was applied three times per week for 4 weeks. Greater volume of newly formed bone was observed in the irradiated group with 10.2 J/cm. In both irradiated groups, a greater volume of newly formed bone occurred only in the first 2 weeks. The results demonstrated that laser irradiation at the grafted site stimulated osteogenesis during the initial stages of the healing process in a skull defect of the rat and that this effect was dose dependent.
da Silva
Rosane Vierra
RV
Department of Anatomy, Institute of Biology, State University of Campinas, UNICAMP, São Paulo, Brazil.
Camilli
José Angelo
JA
D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density; D001861:Bone Regeneration / Q000528:radiation effects*; D016025:Bone Transplantation / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D028022:Low-Level Light Therapy; D008297:Male; D010294:Parietal Bone / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar