FcgammaR and multiple sclerosis: an overview.
Receptors for the Fc domain of IgG (FcgammaR) play a key role in the immune system by linking the cellular and humoral immune systems. Despite extensive documentation of CNS-specific antibodies in cerebrospinal fluid and plaques in multiple sclerosis (MS) patients, the role of FcgammaR in this disease remains largely unexplored. Studies indicate however, that polymorphisms in some FcgammaR genes and treatment that induces FcgammaR on immune-competent cells could influence disease progression and treatment response.
Torkildsen
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The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway. oivind.torkildsen@gmail.com
Vedeler
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Nyland
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HI
Myhr
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011110:Polymorphism, Genetic; D011239:Prednisolone / Q000627:therapeutic use; D017452:Receptors, IgG / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D017452:Receptors, IgG; D011239:Prednisolone