title: Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung.
abstract: Paraneoplastic cerebellar degeneration (PCD) is the most frequent paraneoplastic syndrome affecting the brain. Until now, anti-Tr associated PCD was only seen in patients with Hodgkin's disease. We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria. Extensive diagnostic approach initially showed no evidence of tumor. The patient was found to have anti-Tr antibodies in his serum. Fourteen months after onset of symptoms a whole body PET-scan showed a pathological focus at the right hilus of the lungs. A mediastinoscopy was performed and peribronchial node sampling was done. The anatomopathological analysis revealed a non-well differentiated squamous cell carcinoma. This is the first report about the association between an anti-Tr associated PCD and squamous cell carcinoma.
authors.affiliation: Laboratory of Neurochemistry and Behavior, Departement of Neurology, Algemeen Ziekenhuis Middelheim, Born Bunge Foundation, University of Antwerp, Neurological Center, General Hospital Middelheim, Lindendreef 1, 2020 Antwerpen, Antwerp, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Bruylant
authors.forename: R
authors.initials: R
authors.lastname: Crols
authors.forename: R L
authors.initials: RL
authors.lastname: Humbel
authors.forename: B
authors.initials: B
authors.lastname: Appel
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000368:Aged; D000906:Antibodies / Q000276:immunology*; D001921:Brain / Q000473:pathology*; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000906:Antibodies; C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins