Lactam synthesis via the intramolecular hydroamidation of alkynes catalyzed by palladium complexes.
The palladium complexes catalyzed intramolecular hydroamidation reaction of amidoalkynes gives the corresponding lactams in good to high yields. For example, in the presence of 10 mol % of Pd(PPh3)4 and 20 mol % of PhCOOH, the reaction of the amidoalkyne 3a in 1,4-dioxane at 100 degrees C proceeded smoothly to give the corresponding lactam 4a in 92% yield.
Patil
Nitin T
NT
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Huo
Zhibao
Z
Bajracharya
Gan B
GB
Yamamoto
Yoshinori
Y