Stereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mould.
Dimeric indole alkaloid, anhydrovinblastine, which can be obtained from catharanthine and vindoline in a high yield, was converted stereoselectively into vinblastine through alternating oxidation-reduction with oxygen and NaBH(3)CN in the presence of anti-vinblastine monoclonal antibody.
Shirahama
Tatsuya
T
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan.
Kohno
Takeyuki
T
Kaijima
Tomohiro
T
Nagaoka
Yasuo
Y
Morimoto
Daisuke
D
Hirata
Kazumasa
K
Uesato
Shinichi
S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D001894:Borohydrides; D002851:Chromatography, High Pressure Liquid; D006825:Hybridomas; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology; D012710:Serum Albumin, Bovine; D013237:Stereoisomerism; D013954:Thyroglobulin / Q000737:chemistry; D014747:Vinblastine / Q000037:antagonists & inhibitors / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D000972:Antineoplastic Agents, Phytogenic; D001894:Borohydrides; D007202:Indicators and Reagents; D012710:Serum Albumin, Bovine; D014747:Vinblastine; C025364:sodium borohydride; D013954:Thyroglobulin; D010100:Oxygen