Three cases of pancreatic serous cystadenoma and endocrine tumour.
OBJECTIVE
To report three cases of serous cystadenoma and endocrine tumour in the same pancreas, to review the literature and to evaluate the clinicopathological features of the tumours.


METHODS
Three women (71, 57 and 31 years old) were admitted to hospital, two for diseases unrelated to the pancreas and the third for increasing obstructive jaundice in von Hippel-Lindau disease. Preoperative examination showed two distinct lesions in the first patient and only cystic lesions in the other two.


RESULTS
Histological examination of the pancreas showed one serous oligocystic adenoma associated with a benign, well-differentiated endocrine tumour, one serous oligocystic adenoma associated with an endocrine microadenoma, and a von Hippel-Lindau-related cystic neoplasm with a well-differentiated endocrine carcinoma.


CONCLUSIONS
Serous cystadenoma associated with endocrine tumour shows some clinicopathological differences with respect to the two tumours considered separately, and with respect to von Hippel-Lindau-related cases, although there is no convincing evidence at present to justify considering this association as a separate entity.
Blandamura
Stella
S
Department of Oncological and Surgical Sciences, Section of Pathological Anatomy, University of Padova, Padova, Italy. stella.blandamura@unipd.it
Parenti
Anna
A
Famengo
Barbara
B
Canesso
Alessandra
A
Moschino
Paolo
P
Pasquali
Claudio
C
Pizzi
Sara
S
Guzzardo
Vincenza
V
Ninfo
Vito
V
D000328:Adult; D000368:Aged; D018293:Cystadenoma, Serous / Q000378:metabolism / Q000473:pathology*; D004701:Endocrine Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D006623:von Hippel-Lindau Disease / Q000378:metabolism / Q000473:pathology
D009363:Neoplasm Proteins