title: [Short peptide fragments with antiulcer activity from a collagen hydrolysate].
abstract: A peptide acidic hydrolysate of collagen (PHC) was obtained under conditions (4 N HCl) ensuring the predominant formation of short peptides, glyprolines. They were separated and their antiulcer activity was studied. Thirty individual peptides with molecular masses of 174-420 amu were isolated from the PHC by HPLC. The PHC was shown to predominantly contain 2- to 4-aa peptides, including PG, GP, and PGP. Experiments on rats demonstrated that, on intragastric administration at a dose of 1 mg/kg, PHC enhances the stability of the gastric mucosa to the action of ulcerogenic factors, such as ethanol and stress, and exhibits a protecting antiulcer effect. Even a lesser dose (0.1 mg/kg), which reduced ulcer area twofold, was effective in the stress model of ulcer formation. The intraperitoneal and intragastric administration of PHC at a dose of 1 mg/kg was found to exhibit a therapeutic effect in the acetate model of ulcer formation.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zolotarev
authors.forename: K E
authors.initials: KE
authors.lastname: Badmaeva
authors.forename: Z V
authors.initials: ZV
authors.lastname: Bakaeva
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: G N
authors.initials: GN
authors.lastname: Kopylova
authors.forename: A K
authors.initials: AK
authors.lastname: Dadaian
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Zverkov
authors.forename: S K
authors.initials: SK
authors.lastname: Garanin
authors.forename: B V
authors.initials: BV
authors.lastname: Vas'kovskiĭ
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000737:chemistry*; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects; D006868:Hydrolysis; D008297:Male; D010446:Peptide Fragments / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013315:Stress, Psychological / Q000150:complications
chemical_list: D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D000431:Ethanol; D003094:Collagen