Facile synthesis of mono-, di-, and trisubstituted alpha-unbranched hydrazines.
Methods for the alkylation of di-tert-butyl hydrazine-1,2-dicarboxylate were investigated. It was found that under mild conditions mono- or di-substituted hydrazine derivatives were obtained in good to excellent yield. Furthermore, it was shown that one of the two Boc-groups of the disubstituted derivatives was selectively removed by heating, leading to precursors for trisubstituted hydrazines.
Rasmussen
Lars K
LK
The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. lars@kemiker.dk
D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry
D006834:Hydrazines