Cytotoxic dihydroagarofuranoid sesquiterpenes from the stem of Microtropis fokienensis.
Four dihydroagarofuran sesquiterpene polyesters (1-4) have been isolated from the stem of Microtropis fokienensis. The structures of these new compounds were determined through spectroscopic analyses. Compound 1, 2, 3, and 4 exhibited cytotoxicities (IC(50) values < 0.1 microg/mL) against P-388 and HT-29 cell lines in vitro.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, Republic of China. jjchen@mail.tajen.edu.tw
Chou
Tsung-Hsien
TH
Duh
Chang-Yih
CY
Chen
Ih-Sheng
IS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013624:Taiwan
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes