title: Worsening of obsessive-compulsive symptoms under methadone tapering.
abstract: There is data supporting the hypothesis that the endogenous opioid system may play a role in the pathophysiology of Obsessive Compulsive Disorder (OCD). The authors report a case of worsening of OCD during methadone tapering, which seems to confirm the role of the opioid system in the pathophysiology of OCD. The possible involvement of the cortico-limbic-basal-ganglia-thalamic circuit in the observed phenomenon is discussed.
authors.affiliation: Département Universitaire de Psychiatrie Adulte, Prilly - Lausanne, Switzerland. yasser.khazaal@chuv.ch <yasser.khazaal@chuv.ch>
authors.forename: Yasser
authors.initials: Y
authors.lastname: Khazaal
authors.forename: Sonia
authors.initials: S
authors.lastname: Krenz
authors.forename: Messaoud
authors.initials: M
authors.lastname: Benmebarek
authors.forename: Daniele Fabio
authors.initials: DF
authors.lastname: Zullino
mesh_terms: D000328:Adult; D000075202:Contraindications; D006801:Humans; D008297:Male; D008691:Methadone; D009294:Narcotics; D009771:Obsessive-Compulsive Disorder / Q000534:rehabilitation*
chemical_list: D009294:Narcotics; D008691:Methadone