Expansion of large granular lymphocytes following Pseudomonas infection in a patient with adult-onset Still's disease.
We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without any evidence of active viral activation, hemophagocytosis, or malignancies. The increased LGL cells were CD3(+)CD8(+), and disappeared promptly after the administration of antibiotics combined with prednisolone, with subsequent stabilization of her general condition.
Tabata
Rie
R
Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi, Amagasaki, 661-0012, Japan. fumitabata@oct.zaq.ne.jp
Tabata
Chiharu
C
Fukuda
Hiromi
H
Kotani
Hiroyuki
H
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017252:CD3 Complex / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077731:Meropenem; D011239:Prednisolone / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000150:complications / Q000473:pathology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification* / Q000472:pathogenicity; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D013845:Thienamycins / Q000627:therapeutic use; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D017252:CD3 Complex; D016827:CD8 Antigens; D013845:Thienamycins; D011239:Prednisolone; D000077731:Meropenem