title: Creatine kinase mb, cardiac troponin T and cardiac troponin I as the markers of rhabdomyolysis in chronic hemodialysis patients.
abstract: We designed this study to compare serum markers of myocardial injury creatine kinase MB (CK-MB), as well, as serum contractile proteins, especially cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in dialysis patients without acute ischemic heart disease. 24 patients on chronic hemodialysis were studied by history and physical examination, electrocardiography, and two-dimensional echocardiography. These patients had no evidence of ischemic heart disease. Biochemical markers were measured in serial predialysis blood samples with specific monoclonal antibody-based immunoassays. For several patients at least one sample measured above the upper reference limit: CK-MB, 7 of 24 (30%); ELISA cTnT, 17 of 24 (71%); Enzymun cTnT, 3 of 18 (17%); and cTnI, 1 of 24 (4%). Chronic dialysis patients without acute ischemic heart disease frequently had increased serum CK-MB and cTnT. Our finding are in agreement with the conclusions that cTnT and CK-MB detected in the serum of patients on chronic hemodialysis originates from the skeletal muscle and not from the heart.
authors.affiliation: Department of Hemodialysis and Detoxication, Tbilisis State Medical University Clinic, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Sutidze
authors.forename: M
authors.initials: M
authors.lastname: Sulakvelidze
authors.forename: D
authors.initials: D
authors.lastname: Kochiashvili
authors.forename: D
authors.initials: D
authors.lastname: Labadze
authors.forename: I
authors.initials: I
authors.lastname: Rukhadze
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D052279:Creatine Kinase, MB Form / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D012206:Rhabdomyolysis / Q000453:epidemiology* / Q000378:metabolism*; D019210:Troponin I / Q000378:metabolism*; D020107:Troponin T / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T; D052279:Creatine Kinase, MB Form