title: [Determination of P53 in infiltrative primary bladder tumors as a prognostic factor for understaging].
abstract: OBJECTIVE
  To determine if p53 expression in patients with infiltrative bladder cancer is a prognostic factor on clinical staging and cancer specific survival.
  
  
  METHODS
  Immunohistochemical analysis of p53 in 34 patients (33 males and 1 female) undergoing radical cystectomy for infiltrative bladder cancer, with a mean follow-up of 16 months.
  
  
  RESULTS
  p53 overexpression was detected in 18 patients (64%). In the p53 positive group two patients were stage T1G3, 18 patients T2, 1 patient T3, and 2 patients T4. In the negative group a better correspondence between TUR and cystectomy stage was found, with stage worsening only in 3 patients. On follow-up, p53 positive patients showed worse outcomes due to their worse stages, although no statistical differences were found (p = 0.24). In the group of patients following a bladder sparing protocol (n = 6), p53 negative patients had complete remission of the disease.
  
  
  CONCLUSIONS
  We see significant differences on understaging/more aggressive local outcome in p53 positive patients, with no greater mortality in this group. P53 expression does not contraindicate the inclusion of a patient in a bladder sparing protocol, although larger studies would be necessary to confirm these results.
authors.affiliation: Unidad de Urología Oncológica, Servicio de Anatomía Patológica, Fundació Puigvert, Universidad Autónoma de Barcelona, España,
authors.forename: Mireia
authors.initials: M
authors.lastname: Musquera Felip
authors.forename: Juan
authors.initials: J
authors.lastname: Palou Redorta
authors.forename: Pietro
authors.initials: P
authors.lastname: Moscatiello
authors.forename: Jorge
authors.initials: J
authors.lastname: Huguet Pérez
authors.forename: Oscar
authors.initials: O
authors.lastname: Rodríguez Faba
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Ribal Caparrós
authors.forename: Ferrán
authors.initials: F
authors.lastname: Algaba Arrea
authors.forename: Humberto
authors.initials: H
authors.lastname: Villavicencio Mavrich
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000628:therapy
chemical_list: D016159:Tumor Suppressor Protein p53