Acute renal failure after liver transplantation: incidence, etiology, therapy, and outcome.
Acute renal failure (ARF) was a frequent complication after orthotopic liver transplantation (OLT) when ARF was defined by a calculated glomerular filtration rate decrease of >50% or by a doubled serum creatinine above 2.5 mg/dL within the first week after OLT. We analyzed 1352 liver transplant recipients in retrospective fashion with regard to the incidence, etiology, therapy, and outcome of ARF; 162 patients developed ARF within the first week after OLT (12%), among whom 157 patients (97%) were recompensated by postoperative day 28. Altogether 52 patients (32%) received an average of 6 hemodialysis treatments, excluding the 5 patients (3%) who developed end-stage renal failure. Risk factors for this complication included hepatorenal syndrome type II, a glomerular filtration rate of <50 mL/min, and a diagnosis of hepatitis C.
Junge
G
G
Klinik f. Allgemein-, Viszeral- und Transplantationschirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Schewior
L V
LV
Kohler
S
S
Neuhaus
R
R
Langrehr
J M
JM
Tullius
S
S
Kahl
A
A
Frei
U
U
Neuhaus
P
P
D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology; D001806:Blood Urea Nitrogen; D005260:Female; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome