Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.
Capitano
Blair
B
School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St., Pittsburgh, PA 15261, USA. capitanob@upmc.edu
Potoski
Brian A
BA
Husain
Shahid
S
Zhang
Shimin
S
Paterson
David L
DL
Studer
Sean M
SM
McCurry
Kenneth R
KR
Venkataramanan
Raman
R
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D001999:Bronchoscopy; D002851:Chromatography, High Pressure Liquid; D002985:Clinical Protocols; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008172:Lung Diseases, Fungal / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010994:Pleura / Q000378:metabolism; D011446:Prospective Studies; D011743:Pyrimidines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012015:Reference Standards; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014508:Urea / Q000097:blood; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D014508:Urea; D065819:Voriconazole