title: [Improvement in breast cancer survival between 1975 and 2003 in a cohort of 5722 women].
abstract: To evaluate improvement in breast cancer management between 1975 and 2003, we constituted a cohort of 5722 women with an invasive non-metastatic breast cancer. An active follow-up was carried out and completed using administrative databases. Survival rates were computed using a classical person-time and a period analyses. Relative survival rates were also presented. Advanced cancers at diagnosis decreased from 70.7% to 45.5% between 1975 and 2003. Person-time analysis showed a 48.8% reduction in death rates over 30 years. Survival at 10 years ranged from 50% (CI95% = 45-55) for women diagnosed in 1975-1979 to 66% (CI95% = 63-69) for those diagnosed in 1990-1994. Using period analysis, we estimated the 10 year survival of women diagnosed in 2000-2003 to be 68% (CI95% = 64-72). Overall relative survival was 76% (CI95% = 71-80) at 10 years. Taking into account known prognosis factors, survival was significantly improved for recent diagnosis periods (p<0.00001). Observed improvement in survival confirmed 'in real life' data from clinical trials.
authors.affiliation: Département d'oncologie génétique, prévention et dépistage, UMR Inserm 599, institut Paoli-Calmettes. huiartl@marseille.fnclcc.fr
authors.forename: Laetitia
authors.initials: L
authors.lastname: Huiart
authors.forename: Valérie-Jeanne
authors.initials: VJ
authors.lastname: Bardou
authors.forename: Brigitte
authors.initials: B
authors.lastname: Puig
authors.forename: Dominique
authors.initials: D
authors.lastname: Maraninchi
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors