title: Molecular biology in prostate cancer.
abstract: Genes involved in cancer generation are usually tumor suppressors and oncogenes. Progressive genetic alterations in these genes are involved in the mechanisms of tumorigenesis. In prostate cancer, additionally several chromosomal loci that should harbor mutated genes have been proposed. Some genes have been found altered in prostate cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1 and those can be natural targets for new strategies of treatment. Besides, gene therapy has been suggested to be suitable for prostate cancer treatment. This approach includes ex vivo corrective therapy, suicide, and antisense therapy.
authors.affiliation: Urology Service, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Cansino Alcaide
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Piñeiro
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000628:therapy*