Pain and distress: what really matters?
Federal regulations mandate the minimization of both pain and distress in laboratory animals. That no clear definition exists for 'distress' complicates its recognition, quantification, and alleviation. The author argues that IACUCs and investigators should shift their focus from pain to distress, and that in doing so both problems will be better dealt with. She discusses criteria for defining 'significant' distress, and offers suggestions for the conduct of studies to determine levels of distress.
Koch
V Wensley
VW
USDA, APHIS, Animal Care. vwkoch@hotmail.com
D035661:Animal Care Committees; D000827:Animal Welfare / Q000331:legislation & jurisprudence* / Q000592:standards; D000818:Animals; D000830:Animals, Laboratory / Q000502:physiology*; D010146:Pain / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology; D010147:Pain Measurement; D013315:Stress, Psychological / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology; D014730:Veterinary Medicine