Effect of Helicobacter pylori infection on deep vein thrombosis seen in patients with Behçet's disease.
OBJECTIVE
To investigate the role of homocysteine metabolism due to Helicobacter pylori infection on the development of deep vein thrombosis (DVT) in patients with Behcet's disease (BD).


METHODS
Prospective clinical study.


METHODS
Teaching hospital.


METHODS
Fifty-five patients with BD divided into groups, with DVT and without DVT, 19 healthy individuals and 18 patients with coronary artery disease (CAD) were enrolled into the study.


METHODS
Plasma homocysteine and Hp seropositivity were determined.


RESULTS
There was significant Hp positivity in all groups (p > 0.05). Homocysteine levels were not significantly different for each group except patients with CAD (p > 0.05).


CONCLUSIONS
There was no difference for frequency of Hp infection in all groups. We conclude that Hp does not influence DVT seen in BD via homocysteine metabolism, but the methinnin-loading test would be appropriate for enlighting patients whose fasting plasma homocysteine levels are found to be normal.
Sentürk
O
O
Department of Gastroenterology, Faculty of Medicine, Kocaeli University, P.O. Box 41900 Sopali, Derince/Kocaeli, Turkey.
Ozgür
O
O
Hülagü
O S
OS
Cantürk
N Z
NZ
Celebi
A
A
Karakaya
A T
AT
D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000382:microbiology*; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006710:Homocysteine / Q000378:metabolism*; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020246:Venous Thrombosis / Q000150:complications / Q000382:microbiology*
D006710:Homocysteine