title: Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area.
abstract: BACKGROUND
  Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance.
  
  
  OBJECTIVE
  To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema.
  
  
  METHODS
  The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti.
  
  
  RESULTS
  More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P<0.005 compared with controls). The number of lesions was the strongest predictor of frequency of ADLA. Only 18% of the lesions had positive microscopy or culture for fungi (dermatophytes and Scytalidium).
  
  
  CONCLUSIONS
  These findings highlight the importance of interdigital entry lesions as risk factors for episodes of ADLA and have implications for the control of morbidity from filarial lymphoedema.
authors.affiliation: Department of Mycology, St John's Institute of Dermatology. King's College, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: McPherson
authors.forename: S
authors.initials: S
authors.lastname: Persaud
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: M P
authors.initials: MP
authors.lastname: Fay
authors.forename: D
authors.initials: D
authors.lastname: Addiss
authors.forename: T B
authors.initials: TB
authors.lastname: Nutman
authors.forename: R
authors.initials: R
authors.lastname: Hay
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003881:Dermatomycoses / Q000150:complications / Q000453:epidemiology; D004605:Elephantiasis, Filarial / Q000150:complications / Q000453:epidemiology*; D019353:Endemic Diseases; D005260:Female; D005533:Foot Dermatoses / Q000150:complications / Q000453:epidemiology* / Q000469:parasitology; D006172:Guyana / Q000453:epidemiology; D006801:Humans; D008199:Lymphadenitis / Q000453:epidemiology* / Q000382:microbiology; D008209:Lymphedema / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000453:epidemiology; D012720:Severity of Illness Index; D014034:Toes