[The effect of contraceptive with 20 ug ethinylestradiol and 150 ug desogestrel on some acute phase proteins].
BACKGROUND
We present the influence of monophasic combined oral contraceptive with 20 mmicrog ethinylestradiol /150 microg desogestrel upon some acute phase proteins: C- reactive protein, fibrinogen, haptoglobin and the connection between the proinflammatory effect of oestrogens


METHODS
Forty clinically healthy young women between 18 and 35 years, using oral contraceptives in the duration of 12 months, are included in this study.


RESULTS
We don't find statistically significant differences in the plasma concentrations of C--reactive protein, fibrinogen, haptoglobin on the 12th month of the using of the oral contraceptives in comparision with the initial levels of the variables, before starting the study.


CONCLUSIONS
The reduction of the dose of ethinylestradiol, definitely reduces the effects of oral contraceptives upon acute phase proteins and eventually the increased risk of cardiovascular disease.
Uchikova
E
E
Batashki
I
I
Milchev
N
N
Mateva
N
N
Markova
D
D
Gŭrova
A
A
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D017135:Desogestrel / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D013997:Time Factors
D000209:Acute-Phase Proteins; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D003280:Contraceptives, Oral, Synthetic; D004997:Ethinyl Estradiol; D017135:Desogestrel