title: Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation.
abstract: Analytical procedure has been developed for the gas chromatographic determination of phenylpropanolamine (PPA) using trifluoroacetylacetone (FAA) as derivatizing reagent. Elution is carried out from the column HP-5 (30 mx0.32 mm i.d.) with film thickness 0.25 microm at initial column temperature 70 degrees C for 5 min, followed by heating rate 10 degrees C/min up to 120 degrees C. Injection port temperature was maintained at 270 degrees C. Nitrogen flow rate was 2 ml/min and detection was by FID. The linear calibration curve was obtained with 30-150 microg/ml PPA with detection limit of 6.0 microg/ml. The method was used for the determination of PPA from Sinutab and Tavegyl-D tablets. The relative standard deviation (R.S.D.) for the analysis of pharmaceutical preparation was obtained within 0.4-0.9%.
authors.affiliation: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan.
authors.forename: K
authors.initials: K
authors.lastname: Abbasi
authors.forename: M I
authors.initials: MI
authors.lastname: Bhanger
authors.forename: M Y
authors.initials: MY
authors.lastname: Khuhawar
mesh_terms: D002138:Calibration; D002849:Chromatography, Gas / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010665:Phenylpropanolamine / Q000032:analysis*; D015203:Reproducibility of Results; D013566:Sympathomimetics / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D013566:Sympathomimetics; D010665:Phenylpropanolamine