title: Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue.
abstract: Primary invasive aspergillosis of the gut is a rare event and is associated with high mortality. We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation. Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination. No other site of invasive aspergillosis was evident. The patient was successfully treated with early surgery and combination antifungal therapy.
authors.affiliation: Department of Pediatric Hematology, Johann Wolfgang University of Frankfurt, Germany. thomas.lehrnbecher@kgu.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehrnbecher
authors.forename: Martina
authors.initials: M
authors.lastname: Becker
authors.forename: Dirk
authors.initials: D
authors.lastname: Schwabe
authors.forename: Ulrike
authors.initials: U
authors.lastname: Köhl
authors.forename: Susanne
authors.initials: S
authors.lastname: Kriener
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Hunfeld
authors.forename: Helga
authors.initials: H
authors.lastname: Schmidt
authors.forename: Peter
authors.initials: P
authors.lastname: Beyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.forename: Peter
authors.initials: P
authors.lastname: Bader
authors.forename: Jan
authors.initials: J
authors.lastname: Sörensen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D008297:Male; D017599:Neuroectodermal Tumors / Q000188:drug therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents