title: Edaravone inhibits the disease activity in rheumatoid arthritis.
abstract: A male patient with rheumatoid arthritis (RA) developed acute stroke and was treated with the free radical scavenger, edaravone. Polyarthralgia improved with a reduction in serum C-reactive protein concentration soon after the start of edaravone administration. The disease activity score 28 (DAS28) also decreased. Edaravone appears to be effective for the control of RA. The usefulness of this potentially novel therapeutic agent should be tested in a well designed randomized controlled trial.
authors.affiliation: Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Japan. ariik@med.kochi-u.ac.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Arii
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kumon
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suehiro
authors.forename: Kozo
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000150:complications
chemical_list: D016166:Free Radical Scavengers; D002097:C-Reactive Protein; D000077553:Edaravone; D000983:Antipyrine