title: [Comparison of wound healing after pancreaticojejunostomy with three anastomotic methods in piglets].
abstract: OBJECTIVE
  To evaluate wound healing after pancreaticojejunostomy of three anastomotic methods.
  
  
  METHODS
  Fifty-four domestic piglets were divided into three groups according to the types of anastomoses: group of end-to-end pancreaticojejunal invagination (EE group), group of binding pancreaticojejunostomy (BP group) and group of inkwell pancreaticojejunostomy (IP group). Bursting pressure, breaking strength and histopathological findings of anastomosis were assessed on operative day and on the 5th and 10th day after operation.
  
  
  RESULTS
  Bursting pressure was (67+/-8) mm Hg, (96+/-11) mm Hg and (131+/-9) mm Hg in EE group on day 0, 5 and 10; and (140+/-8) mm Hg, (179+/-10) mm Hg and (269+/-13) mm Hg in BP group; and (102+/-10) mm Hg, (171+/-18) mm Hg and (254+/-24) mm Hg in IP group. Compare to EE group, bursting pressure of BP group and IP group were all increased with significant differences (P<0.05). Another significant difference was observed between BP group and IP group after anastomoses on operative day. Breaking strength was (4.6+/-0.6) N, (5.8+/-0.5) N and (7.1+/-0.6) N in EE group on 0 d, 5 d and 10 d; and (4.5+/-0.4) N, (6.6+/-0.4) N and (10.0+/-0.6) N in BP group; and (4.6+/-0.3) N, (6.5+/-0.4) N and (9.1+/-0.9) N in IP group. A similar value of anastomoses was shown in BP group and IP group on day 0, day 5 and day 10, but significant increase was demonstrated compared to EE group on day 5 and 10. Anastomotic site was well repaired by connective tissue and the cut surface of pancreatic stump was covered by mucosal epithelium in BP group and IP group on day 10, but the cut surface was incompletely repaired by granulation tissue and no regeneration of the epithelium was found in EE group.
  
  
  CONCLUSIONS
  Wound healing of binding pancreaticojejunostomy and inkwell pancreaticojejunostomy is more rapid and better than end-to-end pancreaticojejunal invagination, but breaking strength of inkwell pancreaticojejunostomy is weaker than binding pancreaticojejunostomy.
authors.affiliation: Department of General Surgery, the Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China. laoniulyb@163.com
authors.forename: Ying-bin
authors.initials: YB
authors.lastname: Liu
authors.forename: Jin-hui
authors.initials: JH
authors.lastname: Zhu
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Wang
authors.forename: He-qing
authors.initials: HQ
authors.lastname: Fang
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Li
authors.forename: Fu-bao
authors.initials: FB
authors.lastname: Liu
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Xue
authors.forename: Xu-an
authors.initials: XA
authors.lastname: Wang
authors.forename: Wei-long
authors.initials: WL
authors.lastname: Cai
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Shu-you
authors.initials: SY
authors.lastname: Peng
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D005260:Female; D008297:Male; D010193:Pancreaticojejunostomy / Q000009:adverse effects / Q000379:methods*; D054047:Surgical Stomas / Q000473:pathology; D013552:Swine; D014945:Wound Healing