title: Comparison of bovine- and recombinant human-derived hyaluronidase with regard to fertilization rates and embryo morphology in a sibling oocyte model: a prospective, blinded, randomized study.
abstract: The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design. The results of the study demonstrate that Cumulase is safe and effective in an ICSI treatment program and can provide comparable if not improved parameters, including fertilization and embryo developmental rates.
authors.affiliation: Reproductive Biology Associates, Atlanta, Georgia 30342, USA.
authors.forename: Tyl H
authors.initials: TH
authors.lastname: Taylor
authors.forename: Thomas
authors.initials: T
authors.lastname: Elliott
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Colturato
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Straub
authors.forename: Dorothy
authors.initials: D
authors.lastname: Mitchell-Leef
authors.forename: Zsolt P
authors.initials: ZP
authors.lastname: Nagy
mesh_terms: D000328:Adult; D000818:Animals; D002417:Cattle; D017024:Chemotherapy, Adjuvant; D004622:Embryo, Mammalian / Q000033:anatomy & histology* / Q000187:drug effects; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000166:cytology*; D011994:Recombinant Proteins / Q000008:administration & dosage; D035781:Siblings; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D006821:Hyaluronoglucosaminidase