title: Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate.
abstract: The number of diabetic patients is increasing every year, and new model animals are required to study the diverse aspects of this disease. An experimental obese animal model has reportedly been obtained by injecting monosodium glutamate (MSG) to a mouse. We found that ICR-MSG mice on which the same method was used developed glycosuria. Both female and male mice were observed to be obese but had no polyphagia, and were glycosuric by 29 weeks of age, with males having an especially high rate of incidence (70.0%). Their blood concentrations of glucose, insulin, total cholesterol, and triglycerides were higher than in the control mice at 29 weeks. These high concentrations appeared in younger males more often than in females, and were severe in adult males. Also, the mice at 54 weeks of age showed obvious obesity and increased concentrations of glucose, insulin, and total cholesterol in the blood. The pathological study of ICR-MSG female and male mice at 29 weeks of age showed hypertrophy of the pancreatic islet. This was also observed in most of these mice at 54 weeks. It was recognized as a continuation of the condition of diabetes mellitus. From the above results, these mice are considered to be useful as new experimental model animals developing a high rate of obese type 2 (non-insulin dependent) diabetes mellitus without polyphagia.
authors.affiliation: Central Research Laboratories, Research and Development Division, Tsumura & Co, Ibaraki, Japan.
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Nagata
authors.forename: Wataru
authors.initials: W
authors.lastname: Suzuki
authors.forename: Seiichi
authors.initials: S
authors.lastname: Iizuka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tabuchi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Aburada
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D004195:Disease Models, Animal; D005260:Female; D006029:Glycosuria / Q000139:chemically induced; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008820:Mice, Obese; D012970:Sodium Glutamate
chemical_list: D012970:Sodium Glutamate