The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers.
OBJECTIVE
To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers.


METHODS
Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs.


RESULTS
OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs.


CONCLUSIONS
OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
Shu
Yong-Qian
YQ
Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. yongqianshu@hotmail.com
Gu
Yanhong
Y
D015703:Antigens, CD / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000187:drug effects* / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D010844:Picibanil / Q000494:pharmacology*
D015703:Antigens, CD; D016207:Cytokines; D010844:Picibanil