title: Statistical inference in evolutionary models of DNA sequences via the EM algorithm.
abstract: We describe statistical inference in continuous time Markov processes of DNA sequences related by a phylogenetic tree. The maximum likelihood estimator can be found by the expectation maximization (EM) algorithm and an expression for the information matrix is also derived. We provide explicit analytical solutions for the EM algorithm and information matrix.
authors.affiliation: Bioinformatics Research Center, University of Aarhus, Denmark. asger@daimi.au.dk
authors.forename: Asger
authors.initials: A
authors.lastname: Hobolth
authors.forename: Jens Ledet
authors.initials: JL
authors.lastname: Jensen