title: Incidence of disc hemorrhages in open-angle glaucoma before and after trabeculectomy.
abstract: OBJECTIVE
  To investigate the effects of reduction of intraocular pressure (IOP) by surgical intervention on the frequency of disc hemorrhages in eyes with primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  We studied 99 eyes of 99 patients with POAG and 50 eyes of 50 patients with NTG, who underwent trabeculectomy with adjunctive mitomycin C (MMC) and were followed regularly at 1 to 3-month intervals at the Glaucoma Service of Gifu University Hospital. We applied Kaplan-Meier life-table analysis for the detection of disc hemorrhages before and after trabeculectomy.
  
  
  RESULTS
  Trabeculectomy significantly reduced IOP (in POAG: 19.6 +/- 4.4 down to 11.1 +/- 4.2 mm Hg; in NTG: 15.3 +/- 1.5 down to 11.3 +/- 4.5 mm Hg; mean +/- SD). Life-table analysis revealed that the final cumulative probability of detecting a disc hemorrhage after surgery in POAG was 5.5 +/- 2.2% (calculated probability +/- SE) and was significantly lower than that (33.4 +/- 7.8%) before surgery (P < 0.0001, log-rank test). Likewise, the final probability after surgery in NTG was 23.1 +/- 6.3% and was significantly lower than that (42.1 +/- 8.8%) before surgery (P = 0.0063, log-rank test).
  
  
  CONCLUSIONS
  IOP reduction via surgical intervention significantly decreases the frequency of disc hemorrhages in open-angle glaucoma patients.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miyake
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kou
authors.initials: K
authors.lastname: Miyake
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitazawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000963:Antimetabolites / Q000008:administration & dosage; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009898:Optic Disk / Q000473:pathology*; D012166:Retinal Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D014065:Tonometry, Ocular; D014130:Trabeculectomy
chemical_list: D000963:Antimetabolites; D016685:Mitomycin