title: Ibuprofen arginine for pain control during scaling and root planing: a randomized, triple-blind trial.
abstract: OBJECTIVE
  The aim of this controlled clinical trial was to investigate the analgesic efficacy and tolerability of ibuprofen arginine in patients with mild-to-moderate periodontitis during and after non-surgical periodontal treatment.
  
  
  METHODS
  This randomized, triple-blind, placebo-controlled, parallel-group trial assessed the analgesic efficacy of ibuprofen arginine (Spedifen) in patients undergoing routine periodontal scaling and root planing. 64 patients with chronic periodontitis received either 800 mg ibuprofen arginine or placebo 30 min. before treatment. Numeric pain and electronic visual analogue scales ranging from 0 to 100 were used.
  
  
  RESULTS
  The average pain levels during treatment were lower following ibuprofen arginine (quartiles: 0.5, 4.5, 11) compared with placebo (4, 16, 26), corresponding to a percentage reduction in median pain of 72% (p=0.023). The median maximum pain was 28 (inter-quartile range 10-50) following placebo and 10 (4-31) following ibuprofen arginine (p=0.065).
  
  
  CONCLUSIONS
  In patients with mild-to-moderate chronic periodontitis, ibuprofen arginine was safe and superior to placebo for alleviating pain during non-surgical periodontal treatment. Its painless administration and rapid onset of action make it well suitable for pain management in a general dental office.
authors.affiliation: Center for Dental and Oral Medicine, University of Zurich, Zurich, Switzerland. ettlin@zzmk.unizh.ch
authors.forename: Dominik A
authors.initials: DA
authors.lastname: Ettlin
authors.forename: Andreas
authors.initials: A
authors.lastname: Ettlin
authors.forename: Kathrin
authors.initials: K
authors.lastname: Bless
authors.forename: Milo
authors.initials: M
authors.lastname: Puhan
authors.forename: Corrado
authors.initials: C
authors.lastname: Bernasconi
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Tillmann
authors.forename: Sandro
authors.initials: S
authors.lastname: Palla
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Gallo
mesh_terms: D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D001120:Arginine / Q000627:therapeutic use*; D002908:Chronic Disease; D012534:Dental Scaling / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010518:Periodontitis / Q000628:therapy*; D016745:Root Planing / Q000009:adverse effects; D018709:Statistics, Nonparametric; D014098:Toothache / Q000209:etiology / Q000517:prevention & control*
chemical_list: D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D001120:Arginine; D007052:Ibuprofen; C106674:ibuprofen arginine