title: Compensatory responses induced by oxidative stress in Alzheimer disease.
abstract: Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.
authors.affiliation: Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44100, USA.
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Honda
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Siedlak
authors.forename: Peggy L
authors.initials: PL
authors.lastname: Harris
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000222:Adaptation, Physiological; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D018450:Disease Progression; D038362:Glycogen Synthase Kinase 3; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology*; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D017346:Protein Serine-Threonine Kinases; D038362:Glycogen Synthase Kinase 3; C080888:tau-protein kinase