Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin.
The aim of this study was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare solid binary systems. Differential scanning calorimetry, X-ray diffractometry, and particle size analysis were used to characterize the binary systems obtained. Complexes of piribedil and beta-CD could be prepared using the spray-drying method. Dissolution of piribedil was improved to a great extent by the complex prepared.
Demirel
Muzeyyen
M
Department of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey. mdemirel@anadolu.edu.tr
Buyukkoroglu
G
G
Kalava
B S
BS
Yazan
Y
Y
D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D010316:Particle Size; D010891:Piribedil / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000978:Antiparkinson Agents; D047392:beta-Cyclodextrins; D010891:Piribedil; C031215:betadex