Intracameral cefazolin as prophylaxis against endophthalmitis in cataract surgery.
OBJECTIVE
To evaluate the efficacy of prophylactic intracameral cefazolin in preventing endophthalmitis in cataract surgery.


METHODS
Service of Ophthalmology, St. Joan Hospital, Reus, Spain.


METHODS
In this noncontrolled retrospective observational study, all patients had uncombined cataract surgery from January 2001 to December 2004. All cases of postoperative endophthalmitis were related. The patients were classified into 2 groups. The first (n = 3650) had surgery between January 2001 and December 2002, and the second (n = 3618) had surgery between January 2003 and December 2004; the second group received a bolus of intracameral cefazolin instilled at the end of surgery.


RESULTS
The rate of postoperative endophthalmitis was lower in the cases with intracameral injection at the end of surgery (0.055%) than in those without cefazolin injection (0.63%). No patients in the group with intracameral cefazoline developed corneal endothelium or retinal toxicity.


CONCLUSIONS
Intracameral bolus injection of cefazolin (1 mg in 0.1 mL solution) in cataract surgery demonstrated prophylactic efficacy in diminishing the rate of postoperative endophthalmitis without toxic effects on the cornea or retina.
Romero
Pedro
P
Servicio de Oftalmología, Hospital Universitario Sant Joan de Reus, Departamento de Medicina y Cirugía, Universidad Rovira y Virgili, Reus, Spain. promero@grupsagessa.com
Méndez
Isabel
I
Salvat
Merce
M
Fernández
Juan
J
Almena
Matias
M
D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000302:isolation & purification; D002387:Cataract Extraction; D002437:Cefazolin / Q000009:adverse effects / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000382:microbiology / Q000517:prevention & control*; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D002437:Cefazolin