title: Bone mineral density and turnover in non-corticosteroid treated African American children with juvenile rheumatoid arthritis.
abstract: OBJECTIVE
  To determine bone mineral content (BMC), bone mineral density (BMD), Z scores, and markers of bone turnover in African American children with juvenile rheumatoid arthritis (JRA).
  
  
  METHODS
  Eight children with JRA with no prior exposure to corticosteroids were evaluated. Lumbar spine (L1-L4) and total body and total hip BMC and BMD were determined using dual x-ray absorptiometry (DXA), and Z scores (BMD) were calculated. Serum samples of markers of bone turnover including pyridinoline (PYR), N-terminal propeptide of type I procollagen (P1NP), osteocalcin (OC), and bone-specific alkaline phosphatase (BSAP) were measured.
  
  
  RESULTS
  The mean Z score (BMD) at the lumbar spine (L1-L4) in patients with JRA was -1.2+/-0.8. Z scores for total body and total hip were within 1 standard deviation of normal compared with healthy historical controls matched for age, sex, and race.
  
  
  CONCLUSIONS
  BMD was normal for chronological age (defined as Z score >or= 2.0) in African American children with JRA who had not previously been treated with corticosteroids. Further studies are needed on the effects of JRA on skeletal health in African American children.
authors.affiliation: Department of Medicine, Division of Rheumatology; Children's Foundation Research Center at LeBonheur Children's Medical Center; University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Head
authors.forename: Linda K
authors.initials: LK
authors.lastname: Myers
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Watsky
authors.forename: Mark W
authors.initials: MW
authors.lastname: Greenwell
authors.forename: Karen D
authors.initials: KD
authors.lastname: Barrow
authors.forename: Jean A
authors.initials: JA
authors.lastname: Michelson
authors.forename: Laura D
authors.initials: LD
authors.lastname: Carbone
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001741:Black or African American; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D005260:Female; D006621:Hip Joint; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood
chemical_list: D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin; C015484:pyridinoline; D000469:Alkaline Phosphatase