title: Lactam synthesis via the intramolecular hydroamidation of alkynes catalyzed by palladium complexes.
abstract: The palladium complexes catalyzed intramolecular hydroamidation reaction of amidoalkynes gives the corresponding lactams in good to high yields. For example, in the presence of 10 mol % of Pd(PPh3)4 and 20 mol % of PhCOOH, the reaction of the amidoalkyne 3a in 1,4-dioxane at 100 degrees C proceeded smoothly to give the corresponding lactam 4a in 92% yield.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Nitin T
authors.initials: NT
authors.lastname: Patil
authors.forename: Zhibao
authors.initials: Z
authors.lastname: Huo
authors.forename: Gan B
authors.initials: GB
authors.lastname: Bajracharya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamamoto