title: Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.
abstract: Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.
authors.affiliation: Buck Institute for Research in Aging, Novato, CA 94945, USA.
authors.forename: Deepinder
authors.initials: D
authors.lastname: Kaur
authors.forename: Subramanian
authors.initials: S
authors.lastname: Rajagopalan
authors.forename: Shankar
authors.initials: S
authors.lastname: Chinta
authors.forename: Jyothi
authors.initials: J
authors.lastname: Kumar
authors.forename: Donato
authors.initials: D
authors.lastname: Di Monte
authors.forename: Robert A
authors.initials: RA
authors.lastname: Cherny
authors.forename: Julie K
authors.initials: JK
authors.lastname: Andersen
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000367:Age Factors; D000375:Aging; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology; D005293:Ferritins / Q000235:genetics / Q000378:metabolism*; D005452:Fluoresceins; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D008822:Mice, Transgenic; D009410:Nerve Degeneration / Q000139:chemically induced / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009930:Organic Chemicals / Q000378:metabolism; D016622:Silver Staining; D013378:Substantia Nigra / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D005452:Fluoresceins; D009930:Organic Chemicals; C435731:fluoro jade; D005293:Ferritins; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine