New genes in inflammatory bowel disease: lessons for complex diseases?
The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001.
Gaya
Daniel R
DR
Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Russell
Richard K
RK
Nimmo
Elaine R
ER
Satsangi
Jack
J
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000502:physiology; D000818:Animals; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D051197:Toll-Like Receptor 4 / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4