Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene.
OBJECTIVE
To determine whether SNPs within the dopamine transporter gene (DAT) are associated with quantitative phenotypes generated from drug frequency variables in an ADHD sample.


METHODS
35 SNPs were genotyped in and around DAT. We developed a quantitative phenotype at each SNP by weighting the drug frequency variables. The weights were selected to maximize the heritability at each SNP. Once a quantitative phenotype was generated at each SNP, a screening procedure was used to select and test the SNPs with the greatest power to detect an association in DAT.


RESULTS
No SNPs in DAT were associated with the quantitative phenotypes generated from the drug frequency variables after the multiple comparisons adjustment; however, some SNPs achieved nominal significance. A sliding window of analysis of 3 SNPs also resulted in only nominal associations.


CONCLUSIONS
SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD.
Lasky-Su
Jessica
J
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA.
Biederman
Joseph
J
Doyle
Alysa E
AE
Wilens
Timothy
T
Monuteaux
Michael
M
Smoller
Jordan W
JW
Faraone
Stephen
S
D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D017831:Diagnosis, Dual (Psychiatry); D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D019655:Quantitative Trait, Heritable; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology
D050483:Dopamine Plasma Membrane Transport Proteins