Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia.
The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/cerebellar activity in patients with AD (1.4 +/- 0.6) was higher than that of non-AD dementia patients (0.7 +/- 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.
Lampl
Y
Y
Department of Neurology, Edith Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Lorberboym
M
M
Blankenberg
F G
FG
Sadeh
M
M
Gilad
R
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism; D017304:Annexin A5 / Q000378:metabolism; D003704:Dementia / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D015140:Dementia, Vascular / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D006834:Hydrazines; D007275:Injections, Intravenous; D020961:Lewy Body Disease / Q000175:diagnosis / Q000378:metabolism; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids; D010718:Phosphatidylserines / Q000096:biosynthesis*; D010865:Pilot Projects; D013667:Technetium / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
C120392:6-hydrazinopyridine-3-carboxylic acid; D017304:Annexin A5; D006834:Hydrazines; D008024:Ligands; D009539:Nicotinic Acids; D010718:Phosphatidylserines; D013667:Technetium