Effects of 2'-demethoxy-2'-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells.
Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2'-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2'-demethoxy-2'propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
Oda
Taiko
T
Department of Pharmaceutical Sciences, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo 105-8512, Japan.
D000818:Animals; D002460:Cell Line / Q000187:drug effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D006118:Griseofulvin / Q000737:chemistry / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*
D006118:Griseofulvin