title: The diagnostic impact of contrast-enhanced MRI in management of breast disease.
abstract: For effective use, the diagnostic impact of contrast-enhanced breast MRI (CE MRI) needs to be quantified. This is a retrospective study of 441 women who have undergone CE MRI of the breast from 1 July 1997 to 25 March 2002. Indications for CE MRI studies were diagnostic in 176, monitoring chemotherapy in 126 and study of MRI screening for breast cancer (MARIBS) cases in 139. CE MRI results were confusing or incorrect in 6% of the diagnostic group, 13% of the chemotherapy group and 9% of the MARIBS group. In 18 of 38 of these cases CE MRI stimulated further tests to clarify a clinical query. CE MRI resulted in an increase in confidence or change in clinical plan in 46% of the diagnostic group, 72% of the chemotherapy group and 80% of the MARIBS group. In 44 of 283 of these, CE MRI caused a beneficial change in the clinical plan based on conventional radiology. CE MRI results in a positive diagnostic impact above conventional imaging in a clinically important proportion of patients, but gives some false calls in a smaller proportion (8.6%).
authors.affiliation: Department of Clinical Radiology, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DZ, UK.
authors.forename: Sara S
authors.initials: SS
authors.lastname: Upponi
authors.forename: Ruth M L
authors.initials: RM
authors.lastname: Warren
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis* / Q000628:therapy; D015331:Cohort Studies; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA