title: The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
abstract: The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
authors.affiliation: Instituto de Química Médica Juan de la Cierva, 3, 28006 Madrid, Spain.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Alonso De Diego
authors.forename: Marta
authors.initials: M
authors.lastname: Gutiérrez-Rodríguez
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
authors.forename: Rosario
authors.initials: R
authors.lastname: Herranz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martín-Martínez
authors.forename: Edurne
authors.initials: E
authors.lastname: Cenarruzabeitia
authors.forename: Diana
authors.initials: D
authors.lastname: Frechilla
authors.forename: Joaquín
authors.initials: J
authors.lastname: Del Río
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Jimeno
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D016923:Cell Death / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D009842:Oligopeptides; D017470:Receptors, Glutamate; C062053:glycyl-prolyl-glutamic acid