title: The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans.
abstract: Orally ingested probiotic bacteria are able to modulate the immune system. However, differences exist in the immunomodulatory effects of different probiotic strains. Moreover, different regulatory effects, which depend on the health status of the consumer, have been identified. This work describes a randomized, double-blind, placebo-controlled human clinical trial to investigate the immune effects on healthy people of a fermented product containing two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, which was compared with another fermented product, a standard yogurt. Consumption of either the new product or yogurt increased the proportion of phagocytic cells, including monocytes and neutrophils, as well as their phagocytic activity. However, combination of the product containing the strains L. gasseri CECT 5714 and L. coryniformis CECT 5711 also induced an increase in the proportion of natural killer (NK) cells and in IgA concentrations. The effects were higher after two weeks of treatment than after 4 weeks, which suggests regulation of the immune system. In addition, the new product enhanced immunity in the participants to a greater extent than did the control standard yogurt.
authors.affiliation: Immunology and Animal Science Department, Puleva Biotech SA, Granada, Spain. molivares@pulevabiotech.es
authors.forename: Mónica
authors.initials: M
authors.lastname: Olivares
authors.forename: M Paz
authors.initials: MP
authors.lastname: Díaz-Ropero
authors.forename: Nuria
authors.initials: N
authors.lastname: Gómez
authors.forename: Federico
authors.initials: F
authors.lastname: Lara-Villoslada
authors.forename: Saleta
authors.initials: S
authors.lastname: Sierra
authors.forename: Juan A
authors.initials: JA
authors.lastname: Maldonado
authors.forename: Rocío
authors.initials: R
authors.lastname: Martín
authors.forename: Juan M
authors.initials: JM
authors.lastname: Rodríguez
authors.forename: Jordi
authors.initials: J
authors.lastname: Xaus
mesh_terms: D000328:Adult; D000917:Antibody Formation; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000276:immunology; D007778:Lactobacillus; D008297:Male; D010587:Phagocytosis / Q000276:immunology; D019936:Probiotics / Q000008:administration & dosage*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D015014:Yogurt / Q000382:microbiology
chemical_list: D016207:Cytokines; D007136:Immunoglobulins