title: Qatari DNA variation at a crossroad of human migrations.
abstract: Genomic diversity of the Qatari population was investigated by screening 15 autosomal short tandem repeats (STRs). Significant departures from genetic equilibrium were detected at the D13S317, D19S433 and VWA loci, which persisted after applying Bonferroni-type corrections. Gene diversity (GD) values ranged from 0.6851 (TPOX) to 0.8813 (D2S1338), while observed heterozygosity (Ho) oscillated between 0.3388 (D19S433) and 0.8397 (D2S1338). Interestingly, Ho was lower than expected (He) for 14 of the loci analyzed. The information provided by these microsatellite markers was analyzed by means of genetic distances, multidimensional scaling, hierarchical analyses of the molecular variance (AMOVA) and admixture estimations to assess the genetic relationships of Qatar with European, Asian, African and other Middle Eastern populations. The main findings of the study were the genetic uniqueness of the Qatari population, its strong similarity to the United Arab Emirates (UAE) group, a slight genetic differentiation with respect to other Arab populations (Syria and Egypt) and Turkey, and a certain genetic affinity with sub-Saharan African populations. These results are discussed in light of two major issues: the high consanguinity rates characterizing the Qatari population and its strategic geographic position in the Arabian Peninsula close to major migratory routes, an important pivotal contact zone for bidirectional dispersals between Eurasia and Africa.
authors.affiliation: Molecular Biology and Human Diversity Laboratory, Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Pérez-Miranda
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Alfonso-Sánchez
authors.forename: José A
authors.initials: JA
authors.lastname: Peña
authors.forename: Rene J
authors.initials: RJ
authors.lastname: Herrera
mesh_terms: D000483:Alleles; D004641:Emigration and Immigration; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats; D008957:Models, Genetic; D015233:Models, Statistical; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011780:Qatar; D020080:Tandem Repeat Sequences