title: Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines.
abstract: In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.
authors.affiliation: Cellular Biology Department, IB/UNICAMP, PO Box 6109, 13083-863 Campinas, SP, Brazil.
authors.forename: Luciana K
authors.initials: LK
authors.lastname: Kohn
authors.forename: C H
authors.initials: CH
authors.lastname: Pavam
authors.forename: D
authors.initials: D
authors.lastname: Veronese
authors.forename: F
authors.initials: F
authors.lastname: Coelho
authors.forename: J E
authors.initials: JE
authors.lastname: De Carvalho
authors.forename: Wanda P
authors.initials: WP
authors.lastname: Almeida
mesh_terms: D001572:Benzofurans / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; C082022:phthalide