Immunotoxicity of phosphamidon following subchronic exposure in albino rats.
Effect of subchronic doses of phosphamidon exposure on humoral and cell mediated immune (CMI) responses were studied in male albino rats using SRBC, ovalbumin and KLH as antigens. Humoral immune responses were assessed by estimating antibody titre against antigen and splenic plaque forming cells (PFC) assay. CMI responses were studied by using leucocyte migration inhibition (LMI), macrophage migration inhibition (MMI) and delayed type hypersensitivity (DTH) response. Results obtained in the present study revealed marked suppression of humoral and CMI responses in a dose dependent pattern. Hence, suppression of immune responses by phosphamidon even at subchronic doses is clearly an important aspect for its safety evaluation.
Suke
Sanvidhan G
SG
Environmental Biochemistry Laboratory, Department of Biochemistry, University College of Medical Sciences & GTB Hospital (University of Delhi), India.
Ahmed
Rafat S
RS
Tripathi
A K
AK
Chakraborti
Ayanabha
A
Banerjee
B D
BD
D000417:Albinism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology*; D002465:Cell Movement / Q000187:drug effects; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D010707:Phosphamidon / Q000008:administration & dosage* / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010707:Phosphamidon