The structures of fluostatins C, D and E, novel members of the fluostatin family.
Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383. The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy. The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters. These compounds represent the first reported epoxide fluostatins (1, 2) and underline previously found analogies to the group of kinamycin antibiotics.
Schneider
Kathrin
K
Institut für Organische Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, D-10623 Berlin, Germany.
Nicholson
Graeme
G
Ströbele
Markus
M
Baur
Stephanie
S
Niehaus
Jörg
J
Fiedler
Hans-Peter
HP
Süssmuth
Roderich D
RD
D005449:Fluorenes / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism
D005449:Fluorenes