Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines.
In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.
Kohn
Luciana K
LK
Cellular Biology Department, IB/UNICAMP, PO Box 6109, 13083-863 Campinas, SP, Brazil.
Pavam
C H
CH
Veronese
D
D
Coelho
F
F
De Carvalho
J E
JE
Almeida
Wanda P
WP
D001572:Benzofurans / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D001572:Benzofurans; C082022:phthalide