title: Intrathecal baclofen therapy improves functional intelligibility of speech in cerebral palsy.
abstract: OBJECTIVE
  To assess the effect of intrathecal baclofen on spastic dysarthia in cerebral palsy.
  
  
  METHODS
  Single case study.
  
  
  METHODS
  Functional outcome measures, including the Assessment of Intelligibility of Dysarthric Speech, were performed before and after a trial of intrathecal baclofen in an adult patient with spastic dysarthria due to cerebral palsy. The patient proceeded to intrathecal baclofen pump implantation and was reassessed after six months of continuous intrathecal baclofen therapy.
  
  
  RESULTS
  Improvement in function including speech intelligibility was seen following the intrathecal baclofen trial. The improvement was sustained at six months post pump implantation.
  
  
  CONCLUSIONS
  Intrathecal baclofen improved functional intelligibility of speech in a carefully selected subject. The Assessment of Intelligibility of Dysarthric Speech was found to be a useful quantitative tool to assess the effect of intrathecal baclofen on spastic dysarthria.
authors.affiliation: Department of Neurological Rehabilitation, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London WC1N 3BG, UK. siobhan.leary@uclh.nhs.uk
authors.forename: S M
authors.initials: SM
authors.lastname: Leary
authors.forename: P
authors.initials: P
authors.lastname: Gilpin
authors.forename: L
authors.initials: L
authors.lastname: Lockley
authors.forename: L
authors.initials: L
authors.lastname: Rodriguez
authors.forename: L
authors.initials: L
authors.lastname: Jarrett
authors.forename: V L
authors.initials: VL
authors.lastname: Stevenson
mesh_terms: D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications / Q000534:rehabilitation*; D004401:Dysarthria / Q000209:etiology / Q000534:rehabilitation*; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D008297:Male
chemical_list: D018755:GABA Agonists; D001418:Baclofen