From the bench to the bed: individualizing treatment in non-small-cell lung cancer.
At the time of diagnosis, half of lung cancer patients have advanced incurable disease. Different chemotherapy combinations--with or without targeted therapies--yield similar results in spite of the continuous efforts of clinicians. However, molecular biological studies have already shed a great deal of light on the existence of multiple genetic aberrations that can be useful for customizing treatment. mRNA transcripts involved in DNA repair pathways, such as ERCC1 and BRCA1, confer selective resistance to cisplatin or taxanes. Polymorphisms in DNA repair genes and methylation of checkpoint genes in circulating serum DNA could become important predictive markers of survival to certain cisplatin-based regimens. EGFR tyrosine kinase mutations are the crux of targeted therapies.
Santarpia
Mariacarmela
M
Medical Oncology Unit, University of Messina, Messina, Italy.
Altavilla
Giuseppe
G
Salazar
Fernanda
F
Tarón
Miquel
M
Rosell
Rafael
R
D048948:14-3-3 Proteins / Q000235:genetics / Q000502:physiology; D000230:Adenocarcinoma / Q000235:genetics; D000970:Antineoplastic Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D001549:Benzamides; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000628:therapy*; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics; D004843:Epistasis, Genetic; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000502:physiology; D000069347:Erlotinib Hydrochloride; D019398:Genes, BRCA1; D018816:Genes, cdc; D018773:Genes, erbB-1; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D006801:Humans; D000068877:Imatinib Mesylate; D008175:Lung Neoplasms / Q000235:genetics / Q000628:therapy*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use
D048948:14-3-3 Proteins; D000970:Antineoplastic Agents; D001549:Benzamides; D009363:Neoplasm Proteins; D010879:Piperazines; D011743:Pyrimidines; D011799:Quinazolines; D000068877:Imatinib Mesylate; D000069347:Erlotinib Hydrochloride; D019869:Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors