Increased incidence of Parkinson disease among relatives of patients with Gaucher disease.
In a previous study of 99 Ashkenazi Jewish patients with Parkinson disease from Israel who were tested for the six most common mutations for Gaucher disease, 31.3% had at least one Gaucher disease mutation, implying that carrier status per se my be a risk for Parkinson disease. The purpose of this survey was to ascertain the presence of Parkinson disease among Ashkenazi Jewish obligate carriers of Gaucher disease relative to its incidence in a comparable cohort of Ashkenazi Jews who are putatively non-carriers. There was no statistically significant difference in gender or age between the groups (n>100). Among patients, 27.3% reported having a relative with Parkinson disease while among the controls there was a reported 12.3% which was statistically significant (P=0.05). While based completely on subjective reports in a paper-base questionnaire, the results of this survey implicate a high rate of Parkinson disease among individuals with Gaucher disease mutations.
Halperin
Assaf
A
Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel.
Elstein
Deborah
D
Zimran
Ari
A
D015331:Cohort Studies; D005190:Family; D005260:Female; D005776:Gaucher Disease / Q000453:epidemiology* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007557:Israel; D007585:Jews; D008297:Male; D009154:Mutation; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics; D011795:Surveys and Questionnaires