Antimicrobial dialkylresorcinols from Pseudomonas sp. Ki19.
Four dialkylresorcinols (1-4) were isolated from a liquid culture of Pseudomonas sp. Ki19. Compounds 1 and 2, 2-butyl-5-propylresorcinol and 2-hexyl-5-methylresorcinol, respectively, have not previously been isolated from biological sources, whereas 3 and 4, 2-hexyl-5-propylresorcinol (DB-2073) and 2-hexyl-5-pentylresorcinol (resorstatin), both have been found in biological systems. The compounds inhibited Staphyllococcus aureus at concentrations < or = 10 microg/mL as well as the fungi Aspergillus fumigatus and Fusarium culmorum at 50 microg/mL. The formation of possible antimicrobial quinone oxidation products was investigated under bioassay conditions, and they were not found to be responsible for the main antimicrobial activity.
Pohanka
Anton
A
Department of Chemistry, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-750 07 Uppsala, Sweden.
Levenfors
Jolanta
J
Broberg
Anders
A
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D029791:Ericaceae / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011549:Pseudomonas / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013548:Sweden
D000890:Anti-Infective Agents; D012118:Resorcinols