title: Regulating the licensing of DNA replication origins in metazoa.
abstract: Eukaryotic DNA replication is a highly conserved process; the proteins and sequence of events that replicate animal genomes are remarkably similar to those that replicate yeast genomes. Moreover, the assembly of prereplication complexes at DNA replication origins ('DNA licensing') is regulated in all eukaryotes so that no origin fires more than once in a single cell cycle. And yet there are significant differences between species both in the selection of replication origins and in the way in which these origins are licensed to operate. Moreover, these differences impart advantages to multicellular animals and plants that facilitate their development, such as better control over endoreduplication, flexibility in origin selection, and discrimination between quiescent and proliferative states.
authors.affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Building 6/3A-15, 9000 Rockville Pike, Bethesda, MD 20892-2753, USA. depamphm@mail.nih.gov
authors.forename: Melvin L
authors.initials: ML
authors.lastname: DePamphilis
authors.forename: J Julian
authors.initials: JJ
authors.lastname: Blow
authors.forename: Soma
authors.initials: S
authors.lastname: Ghosh
authors.forename: Tapas
authors.initials: T
authors.lastname: Saha
authors.forename: Kohji
authors.initials: K
authors.lastname: Noguchi
authors.forename: Alex
authors.initials: A
authors.lastname: Vassilev
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D004265:DNA Helicases / Q000378:metabolism; D004261:DNA Replication; D006801:Humans; D008957:Models, Genetic; D051738:Origin Recognition Complex / Q000378:metabolism; D010944:Plants / Q000235:genetics; D018741:Replication Origin
chemical_list: D018797:Cell Cycle Proteins; D051738:Origin Recognition Complex; D004265:DNA Helicases