[Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels].
OBJECTIVE
To study the relationship between interleukin-6 (IL-6) gene promoter-572 C/G and -634 C/G polymorphism and coronary heart disease (CHD) and the influence of IL-6 gene polymorphism on plasma lipid and lipoprotein levels.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL-6 genotype in 165 patients with CHD and 170 healthy persons. The plasma lipid and lipoprotein levels were measured by routine method.


RESULTS
Plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the patients with CHD were significantly higher than those of the controls (all P<0.05). The distributions of IL-6 gene -634 C/G polymorphism were not different between CHD group and control group (P>0.05), but the IL-6 gene-572 C/G polymorphism was significantly different between them (P<0.05). The relative risk of CHD of C allele was 1.652 times to the G allele [odds ratio (OR)=1.652, 95% confidence interval (CI): 1.137-2.401]. The level of plasma lipid in G allele carriers was significantly higher than non-carriers (P<0.05).


CONCLUSIONS
IL-6 gene -572 C/G polymorphism is associated with CHD, and G allele is an important genetic marker. IL-6 gene polymorphism may affect CHD through elevation of plasma lipid and lipoprotein levels.
Wei
Ye-sheng
YS
Department of Clinical Laboratory Center, The Affiliated Hospital to Youjiang Nationality Medical College, Youjiang 533000, Guangxi, China. weiyesheng@yahoo.com.cn
Lan
Yan
Y
Liu
Yun-guang
YG
Tang
Ren-guang
RG
Lan
Jing-sheng
JS
D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
C508600:IL6 protein, human; D015850:Interleukin-6; D008055:Lipids