Recent advances in molecular pharmacology of the histamine systems: roles of C-terminal tails of histamine receptors.
G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs. These interactions are implicated in targeting, trafficking, and fine-tuning of signaling of GPCRs. Although the C-terminus of the histamine H2 receptor has been suggested to play in agonist-induced internalization of the receptor, roles of the C-termini of the other three histamine receptors are not known. To date, there is no protein identified to interact with the C-termini of histamine receptors.
Kuramasu
Atsuo
A
Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi, Sendai, Japan. atsuok@mail.tains.tohoku.ac.jp
Sukegawa
Jun
J
Yanagisawa
Teruyuki
T
Yanai
Kazuhiko
K
D004705:Endocytosis; D020555:GTP-Binding Protein Regulators / Q000378:metabolism*; D006801:Humans; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D020555:GTP-Binding Protein Regulators; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2