title: Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.
abstract: Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.
authors.affiliation: Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. lorraine.ware@vanderbilt.edu
authors.forename: Lorraine B
authors.initials: LB
authors.lastname: Ware
authors.forename: Eric
authors.initials: E
authors.lastname: Camerer
authors.forename: Karen
authors.initials: K
authors.lastname: Welty-Wolf
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Schultz
authors.forename: Michael A
authors.initials: MA
authors.lastname: Matthay
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000276:immunology; D004195:Disease Models, Animal; D005342:Fibrinolysis / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D010215:Papio; D011014:Pneumonia / Q000097:blood; D011486:Protein C / Q000378:metabolism / Q000627:therapeutic use; D044462:Receptors, Proteinase-Activated / Q000502:physiology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000276:immunology / Q000628:therapy; D018805:Sepsis / Q000378:metabolism; D018180:Thrombomodulin / Q000097:blood; D013925:Thromboplastin / Q000378:metabolism
chemical_list: D011486:Protein C; D044462:Receptors, Proteinase-Activated; D018180:Thrombomodulin; D013925:Thromboplastin