title: Differences in risk factors for dementia with neurodegenerative traits and for vascular dementia.
abstract: In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E (ApoE), low-density-lipoprotein (LDL)-receptor-related protein, alpha(2)-macroglobulin, interleukin (IL) 1beta, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In plasma, antibodies against Chlamydia pneumoniae and lipids were determined. Dementia was classified as probable Alzheimer's disease (AD), probable dementia of vascular origin (VaD) and mixed dementia (MD). An association of the disease with ApoE and IL-1beta polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD.
authors.affiliation: Department of Genetic, Institute of Psychiatry and Neurology, Warsaw, Poland. wher@ipin.edu.pl
authors.forename: H
authors.initials: H
authors.lastname: Wehr
authors.forename: M
authors.initials: M
authors.lastname: Bednarska-Makaruk
authors.forename: W
authors.initials: W
authors.lastname: Łojkowska
authors.forename: A
authors.initials: A
authors.lastname: Graban
authors.forename: D
authors.initials: D
authors.lastname: Hoffman-Zacharska
authors.forename: A
authors.initials: A
authors.lastname: Kuczyńska-Zardzewiały
authors.forename: J
authors.initials: J
authors.lastname: Mrugała
authors.forename: M
authors.initials: M
authors.lastname: Rodo
authors.forename: A
authors.initials: A
authors.lastname: Bochyńska
authors.forename: A
authors.initials: A
authors.lastname: Sułek
authors.forename: D
authors.initials: D
authors.lastname: Ryglewicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002690:Chlamydia Infections / Q000453:epidemiology / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D002784:Cholesterol / Q000097:blood; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics; D015140:Dementia, Vascular / Q000453:epidemiology* / Q000235:genetics; D004777:Environment; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000453:epidemiology* / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000907:Antibodies, Bacterial; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol