Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection.
Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit).
Ragin
A B
AB
Department of Radiology, The Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ann-ragin@northwestern.edu
Wu
Y
Y
Storey
P
P
Cohen
B A
BA
Edelman
R R
RR
Epstein
L G
LG
D001479:Basal Ganglia / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D002421:Caudate Nucleus / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications* / Q000473:pathology; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018932:Chemokine CCL2; D014409:Tumor Necrosis Factor-alpha