title: Nucleosome dynamics.
abstract: In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.
authors.affiliation: Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DDI 5EH, Scotland, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Stockdale
authors.forename: Michael
authors.initials: M
authors.lastname: Bruno
authors.forename: Helder
authors.initials: H
authors.lastname: Ferreira
authors.forename: Elisa
authors.initials: E
authors.lastname: Garcia-Wilson
authors.forename: Nicola
authors.initials: N
authors.lastname: Wiechens
authors.forename: Maik
authors.initials: M
authors.lastname: Engeholm
authors.forename: Andrew
authors.initials: A
authors.lastname: Flaus
authors.forename: Tom
authors.initials: T
authors.lastname: Owen-Hughes
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001665:Binding Sites; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000235:genetics / Q000378:metabolism; D014644:Genetic Variation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D009707:Nucleosomes / Q000235:genetics* / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D000255:Adenosine Triphosphate; D004247:DNA