title: A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease.
abstract: The DNA binding of a dicationic pyridylimine-based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)(3)](2+) (phen=1,10-phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA-cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Childs
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Malina
authors.forename: Britt Elin
authors.initials: BE
authors.lastname: Rolfsnes
authors.forename: Mirela
authors.initials: M
authors.lastname: Pascu
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Prieto
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Broome
authors.forename: P Mark
authors.initials: PM
authors.lastname: Rodger
authors.forename: Einar
authors.initials: E
authors.lastname: Sletten
authors.forename: Virtudes
authors.initials: V
authors.lastname: Moreno
authors.forename: Alison
authors.initials: A
authors.lastname: Rodger
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hannon
mesh_terms: D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D003851:Deoxyribonucleases / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D011725:Pyridines; D003300:Copper; D004247:DNA; D003851:Deoxyribonucleases