title: Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis.
abstract: Two new sulfated triterpene glycosides, philinopside E (1) and F (2), have been isolated from the sea cucumber Pentacta quadrangularis. Their structures have been established by extensive spectral analysis (NMR and MS) and chemical evidence. Glycoside 1 showed significant cytotoxicity (Ed(50) 0.75-3.50 microg mL(-1)) against ten tumor cell lines.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P.R. China.
authors.forename: Shi-Long
authors.initials: SL
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D006027:Glycosides; C512676:Philinopside E; C512677:Philinopside F; D014315:Triterpenes