title: Is long-term humoral immunity in the mucosa provided by long-lived plasma cells? A question still open.
abstract: The biology of antibody-secreting cells is still a matter of controversial discussion. One of the key questions is how the migration and lifespan of antibody-secreting cells is linked to their generation. A paper in this issue of the European Journal of Immunology provides further information on the generation of long-term mucosal immune responses; however, the study leaves many questions unanswered as discussed in this brief Commentary.
authors.affiliation: Charité-Universitätsmedizin Berlin, Berlin, Germany. falk.hiepe@charite.de
authors.forename: Falk
authors.initials: F
authors.lastname: Hiepe
authors.forename: Andreas
authors.initials: A
authors.lastname: Radbruch
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000502:physiology; D002470:Cell Survival; D006801:Humans; D018928:Immunity, Mucosal; D009297:Nasal Mucosa / Q000276:immunology*; D010950:Plasma Cells / Q000502:physiology*; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D022261:Respiratory Syncytial Virus Vaccines