title: Gonadal steroid regulation of mood: the lessons of premenstrual syndrome.
abstract: New models for menstrual cycle-related mood disorders provide unique opportunities to gain insight into the processing of emotional information and the regulation of mood state by reproductive steroids. This paper reviews the role of reproductive steroids in affect regulation and in premenstrual dysphoric disorder (PMD), parses PMD into component processes that suggest potential mediating neurocircuitry, and highlights the importance of and potential contributors to the differential sensitivity that permits reproductive steroids to destabilize mood in some but not all women.
authors.affiliation: Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1276, USA. rubinowd@mail.nih.gov
authors.forename: David R
authors.initials: DR
authors.lastname: Rubinow
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008183:Luteal Phase / Q000378:metabolism*; D008875:Middle Aged; D011293:Premenstrual Syndrome / Q000378:metabolism*
chemical_list: D012739:Gonadal Steroid Hormones