New images evoke FAScinating questions.
Two recent papers in Science reported the X-ray structures of the large, organizationally distinct animal and fungal fatty acid synthases at 5 A. These new structural insights have unexpected implications for enzyme function for the other "iterative" and "assembly line" megasynthases.
Townsend
Craig A
CA
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Crawford
Jason M
JM
Bililign
Tsion
T
D000818:Animals; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D064429:Fatty Acid Synthases / Q000737:chemistry*; D005658:Fungi / Q000201:enzymology; D008958:Models, Molecular; D015394:Molecular Structure; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary
D064429:Fatty Acid Synthases