title: Dynamics of ocular surface topography.
abstract: OBJECTIVE
  To investigate fluctuations in the ocular surface, we used high-speed videokeratoscopy (50 Hz) to measure the dynamics of the ocular surface topography.
  
  
  METHODS
  Ocular surface height difference maps were computed to illustrate the changes in the tear film in the inter-blink interval. Topography data were used to derive the ocular surface wavefront aberrations up to the fourth radial order of the Zernike polynomial expansion. We examined the ocular surface dynamics and temporal changes in the ocular surface wavefront aberrations in the inter-blink interval.
  
  
  RESULTS
  During the first 0.5 s following a blink, the ocular surface height at the upper edge of the topography map increased by about 2 mum. Temporal changes occurred for some ocular surface wavefront aberrations and appeared to be related to changes in the distribution of tear film.
  
  
  CONCLUSIONS
  In the clinical measurement of ocular surface topography using videokeratoscopy or optics of the eye using wavefront sensors, care should be taken to avoid the initial tear film build-up phase following a blink to achieve more consistent results.
authors.affiliation: Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Kelvin Grove, Australia. zhum@upmc.edu
authors.forename: M
authors.initials: M
authors.lastname: Zhu
authors.forename: M J
authors.initials: MJ
authors.lastname: Collins
authors.forename: D R
authors.initials: DR
authors.lastname: Iskander
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000503:physiopathology; D001767:Blinking / Q000502:physiology; D003315:Cornea / Q000033:anatomy & histology* / Q000502:physiology; D019781:Corneal Topography / Q000379:methods; D005133:Eye Movements / Q000502:physiology; D006801:Humans; D012815:Signal Processing, Computer-Assisted; D013666:Tears / Q000502:physiology*; D014741:Video Recording