title: Familial chordoma. A report of two cases.
abstract: We have treated 175 patients with a chordoma over a ten-year period. Only two had a family history of the condition and we describe these in this paper. In one patient the tumour was at the craniocervical junction and in the other the lesion affected the sacrum. We have undertaken a literature review of familial chordoma and have identified chromosomal abnormalities associated with the condition.
authors.affiliation: National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. arupbhadra@yahoo.com
authors.forename: A K
authors.initials: AK
authors.lastname: Bhadra
authors.forename: A T H
authors.initials: AT
authors.lastname: Casey
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D002574:Cervical Vertebrae / Q000473:pathology / Q000601:surgery*; D002817:Chordoma / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D005192:Family Health; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D010375:Pedigree; D012447:Sacrum / Q000601:surgery*