Antifungal characteristics of N,N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide).
A bis-quaternary ammonium compound (bis-QAC), N,N'-hexamethylenebis(4-carbamoyl-1decylpyridinium bromide) (D-38), exhibited a wide antifungal spectrum and a strong activity against sixteen strains of fungi including nine strains isolated from various kinds of food. The antifungal activity was higher than that of N-dodecylpyridinium Iodide, a typical mono-QAC, and that of the commonly used fungicide, 2-(4-thiazolyl) benzimidazole. The activity of D-38, however, was comparatively low when it was measured by the agar dilution method. It is considered that the hydrophobic D-38 molecules, having two long alkyl chains, interacted with the agar medium, and therefore showed lower activity results. On the other hand, the activity of D-38 against Aspergillus niger IFO 6342 was not significantly influenced by temperature, pH and the initial spore concentration. These results indicate that bis-QACs can exhibit a high antifungal activity whether or not the environmental conditions change.
Okazaki
Kiyo
K
Faculty of Human Life Science, Shikoku University, Furukawa, Ojin-cho, Tokushima 771-1192, Japan.
Yoshida
Munehiro
M
Mayama
Mari
M
Shirai
Akihiro
A
Maeda
Takuya
T
Nagamune
Hideaki
H
Kourai
Hiroki
H
D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D005516:Food Microbiology; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013172:Spores, Fungal; D013696:Temperature; D013827:Thiabendazole / Q000494:pharmacology
D000935:Antifungal Agents; C511336:N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide); D011726:Pyridinium Compounds; C001524:Laurosept; D013827:Thiabendazole