[The clinical significance of the expression of p63 gene in laryngeal squamous cell carcinoma].
OBJECTIVE
To study the expression and clinical significance of p63 gene in laryngeal squamous cell carcinoma(LSCC).


METHODS
The immunohistochemical technique was used to detected the expression of p63 in 63 cases of LSCC, 45 cases of para-cancer tissues, 24 cases of lymph node metastasis, 40 cases of non lymph node metastasis and 25 normal tissues.


RESULTS
The positive overexpression rate of the p63 gene in LSCC (95.24%) and in matched metastatic lymph node (83.3%) was significantly higher than para cancer tissues, non metastasis lymph node and normal tissues (P<0.01). p63 gene expression was not correlation with the clinical stages,clinical typing and pathological classification of the LSCC(P >0.05).


CONCLUSIONS
p63 gene had important clinic significance to the diagnosis and differential diagnosis of the LSCC. It perhaps participate in regulation of tumorigenesis in LSCC, and it may play negative feedback action in the development of LSCC.
Jia
Haiying
H
Departament of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Wang
Jiqun
J
Shan
Yanchun
Y
Hou
Jinghui
J
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging
C081876:CKAP4 protein, human; D008565:Membrane Proteins