title: Somatostatin-related therapeutics in ophthalmology: a review.
abstract: Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled studies and case series. The article points out future possible applications. Larger randomised controlled studies are necessary to confirm its current and future use. New ways of application could facilitate its broader use in ophthalmology.
authors.affiliation: Eye Hospital Rotterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Missotten
authors.forename: G S
authors.initials: GS
authors.lastname: Baarsma
authors.forename: R W A M
authors.initials: RW
authors.lastname: Kuijpers
authors.forename: L I
authors.initials: LI
authors.lastname: van den Born
authors.forename: L I
authors.initials: LI
authors.lastname: van der Born
authors.forename: T
authors.initials: T
authors.lastname: van der Loos
authors.forename: R
authors.initials: R
authors.lastname: Croxen
authors.forename: L J
authors.initials: LJ
authors.lastname: Hofland
authors.forename: P M
authors.initials: PM
authors.lastname: van Hagen
mesh_terms: D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D002455:Cell Division; D005123:Eye / Q000098:blood supply / Q000737:chemistry; D005128:Eye Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009885:Ophthalmology; D017481:Receptors, Somatostatin / Q000032:analysis / Q000502:physiology; D012164:Retinal Diseases / Q000188:drug therapy; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D017481:Receptors, Somatostatin; D013004:Somatostatin