title: Helicobacter pylori: a possible association with otitis media with effusion.
abstract: OBJECTIVE
  Evaluate possible role of Helicobacter Pylori in pathogenesis of otitis media with effusion (OME).
  
  
  METHODS
  Randomized controlled trial, tertiary referral center.
  
  
  METHODS
  Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME.
  
  
  METHODS
  A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5 mm deep tissue specimens were obtained from tonsil and adenoid.
  
  
  RESULTS
  H pylori presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (P<0.05).
  
  
  CONCLUSIONS
  This study is the first to grow H pylori in middle ear in OME. Significantly increased colonization by H pylori of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME.
  
  
  METHODS
  A-1b.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey. tyilmaz@hacettepe.edu.tr
authors.forename: Taner
authors.initials: T
authors.lastname: Yilmaz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceylan
authors.forename: Yakut
authors.initials: Y
authors.lastname: Akyön
authors.forename: Olcay
authors.initials: O
authors.lastname: Ozçakýr
authors.forename: Bülent
authors.initials: B
authors.lastname: Gürsel
mesh_terms: D000234:Adenoids / Q000382:microbiology; D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000235:genetics*; D003937:Diagnosis, Differential; D004432:Ear, Middle / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000382:microbiology*; D014066:Palatine Tonsil / Q000382:microbiology; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies
chemical_list: D004269:DNA, Bacterial