Acute myocardial infarction induced by cisplatin-based combination chemotherapy for malignant melanoma: a case report.
A 61-year-old woman with stage IV malignant melanoma suffered acute myocardial infarction during the third course of chemotherapy with cisplatin, dacarbazine, nimustine hydrochloride and tamoxifen citrate, despite no serious problem occurring during the first and second courses of chemotherapy. Since this patient, excluding menopause, had no significant risk factor for coronary heart disease before the start of chemotherapy, the infarction was likely to be attributable to the chemotherapy regimen. Chemotherapy should be used cautiously in patients with coronary risk factors before treatment is begun.
Fukunaga
Takashi
T
Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
Soejima
Hirofumi
H
Sugamura
Koichi
K
Kojima
Sunao
S
Sugiyama
Seigo
S
Sakamoto
Tomohiro
T
Yoshimura
Michihiro
M
Tanoue
Toshihide
T
Kageshita
Toshiro
T
Ono
Tomomichi
T
Ogawa
Hisao
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002114:Calcinosis / Q000150:complications; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications; D003606:Dacarbazine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis; D015376:Nimustine / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy*; D013629:Tamoxifen / Q000008:administration & dosage
D013629:Tamoxifen; D015376:Nimustine; D003606:Dacarbazine; D002945:Cisplatin