Genetic susceptibility to thrombosis.
Thrombosis is associated with atherosclerosis, sepsis, cancer, and numerous other inflammatory diseases. Complications of thrombosis, such as myocardial infarction, stroke, and venous thromboembolism, contribute significantly to morbidity and mortality. Susceptibility to thrombosis is conferred by both genetic and environmental factors. Tissue factor is the primary cellular initiator of blood coagulation and is a major contributor to thrombosis. In this review, we discuss the association between various polymorphisms and the risk for thrombosis.
Luyendyk
James P
JP
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, CVN-18, La Jolla, CA 92037, USA.
Tilley
Rachel E
RE
Mackman
Nigel
N
D016207:Cytokines / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D011110:Polymorphism, Genetic; D013925:Thromboplastin / Q000235:genetics*; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*
D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D013925:Thromboplastin