Chemoprevention of prostate cancer with finasteride.
Prostate cancer is a significant cause of disease and death, making it an attractive target for chemoprevention. The association between lifetime exposure to dihydrotestosterone and risk of developing prostate cancer suggests that chemoprevention is possible with 5alpha-reductase inhibition. The recently completed Prostate Cancer Prevention Trial indicates that chemoprevention is possible with the 5alpha-reductase inhibitor finasteride. Development of a cost-effective chemoprevention strategy for prostate cancer is evolving, and is expected to have significant positive economic and public health benefits.
Canby-Hagino
Edith D
ED
Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA. canbyhagino@uthscsa.edu
Brand
Timothy C
TC
Hernandez
Javier
J
Thompson
Ian M
IM
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry / Q000627:therapeutic use*; D018120:Finasteride / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000517:prevention & control
D018931:Antineoplastic Agents, Hormonal; D018120:Finasteride