title: Association between solitary keratoacanthoma and cigarette smoking: a case-control study.
abstract: Solitary keratoacanthoma (KA) is a common benign epithelial tumor of the skin characterized by rapid growth and a tendency toward spontaneous regression. The exact etiology and classification of KA are a matter of debate. Smokers also seem to be more affected than persons who never smoke. The objective of this study was to evaluate the association between solitary KA and smoking habit. A case-control study involving 78 patients diagnosed with KA and 199 controls from the related community was performed to evaluate the association between cigarette smoking and KA. A higher smoking prevalence was noted in cases (69.2 %) than controls (21.6 %) and the odds ratio adjusted for sex and age was 9.1 (95 % CI 4.9 to 17.1, p< 0.01). The mean tumoral diameter at surgery and the site of involvement was not statistically related to smoking. These findings suggest that cigarette smoking is associated with the development of KA.
authors.affiliation: Dermatology Department of Unesp Medical School, Botucatu, SP, Brazil. heliomiot@fmb.unesp.br
authors.forename: Hélio Amante
authors.initials: HA
authors.lastname: Miot
authors.forename: Luciane Donida Bartoli
authors.initials: LD
authors.lastname: Miot
authors.forename: Ana Laura Bastos
authors.initials: AL
authors.lastname: da Costa
authors.forename: Cristiane Yuri
authors.initials: CY
authors.lastname: Matsuo
authors.forename: Hamilton Ometto
authors.initials: HO
authors.lastname: Stolf
authors.forename: Mariângela Esther Alencar
authors.initials: ME
authors.lastname: Marques
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D006801:Humans; D007636:Keratoacanthoma / Q000209:etiology*; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*; D011795:Surveys and Questionnaires