title: Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
abstract: Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.
authors.affiliation: School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St., Pittsburgh, PA 15261, USA. capitanob@upmc.edu
authors.forename: Blair
authors.initials: B
authors.lastname: Capitano
authors.forename: Brian A
authors.initials: BA
authors.lastname: Potoski
authors.forename: Shahid
authors.initials: S
authors.lastname: Husain
authors.forename: Shimin
authors.initials: S
authors.lastname: Zhang
authors.forename: David L
authors.initials: DL
authors.lastname: Paterson
authors.forename: Sean M
authors.initials: SM
authors.lastname: Studer
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: McCurry
authors.forename: Raman
authors.initials: R
authors.lastname: Venkataramanan
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D001999:Bronchoscopy; D002851:Chromatography, High Pressure Liquid; D002985:Clinical Protocols; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008172:Lung Diseases, Fungal / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010994:Pleura / Q000378:metabolism; D011446:Prospective Studies; D011743:Pyrimidines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012015:Reference Standards; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014508:Urea / Q000097:blood; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D014508:Urea; D065819:Voriconazole