Parental obesity and overweight affect the body-fat accumulation in the offspring: the possible effect of a high-fat diet through epigenetic inheritance.
The prevalence of obesity in adults has been rising continually, as has the prevalence of childhood obesity, and a large number of epidemiological studies have demonstrated a direct relationship between parental obesity and childhood obesity. In this paper, we review the effect of diet, the intrauterine environment, and the genetic inheritance on obesity. We described a study in detail that used experimental animals as a model to investigate the effect of a parental high-fat diet on body-fat accumulation in their offspring. Fertilized eggs were transplanted in that study, and body-fat accumulation in the offspring of the parents fed a high-fat diet was found to be greater than in the offspring of the parents fed a low-fat diet, even when the experimental conditions were the same in the intrauterine and subsequent environment. The results suggested that a parental high-fat diet before intrauterine developmental stage may increase body-fat accumulation in the offspring. We discuss the possibility that parental diet may influence the lifelong health of offspring and epigenetic inheritance may be occurred.
Wu
Q
Q
Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukuba, Japan.
Suzuki
M
M
D032721:Adult Children; D004041:Dietary Fats / Q000008:administration & dosage*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology; D004777:Environment; D005260:Female; D015438:Health Behavior; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D010290:Parents; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D004041:Dietary Fats