Induction of immunological tolerance using monoclonal antibodies: applications to organ transplantation and autoimmune disease.
Immunologic tolerance is a state of immune paralysis specific to a given antigen (the tolerogen) coexisting with the maintenance of normal immunocompetence towards other antigens. Anti-T cell monoclonal antibodies allow its induction in organ transplantation and autoimmune disease essentially through the stimulation of regulatory T cells. Very promising results obtained in animals have been recently confirmed in the human in recent-onset insulin-dependent diabetes mellitus with an anti-CD3 antibody (with long-term remission of the disease following a treatment of only six days).
Bach
Jean-François
JF
INSERM U580, Hôpital Necker, 161, rue de Sèvres, 75015 Paris, France. bach@necker.fr
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy; D004195:Disease Models, Animal; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016377:Organ Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents