[Short peptide fragments with antiulcer activity from a collagen hydrolysate].
A peptide acidic hydrolysate of collagen (PHC) was obtained under conditions (4 N HCl) ensuring the predominant formation of short peptides, glyprolines. They were separated and their antiulcer activity was studied. Thirty individual peptides with molecular masses of 174-420 amu were isolated from the PHC by HPLC. The PHC was shown to predominantly contain 2- to 4-aa peptides, including PG, GP, and PGP. Experiments on rats demonstrated that, on intragastric administration at a dose of 1 mg/kg, PHC enhances the stability of the gastric mucosa to the action of ulcerogenic factors, such as ethanol and stress, and exhibits a protecting antiulcer effect. Even a lesser dose (0.1 mg/kg), which reduced ulcer area twofold, was effective in the stress model of ulcer formation. The intraperitoneal and intragastric administration of PHC at a dose of 1 mg/kg was found to exhibit a therapeutic effect in the acetate model of ulcer formation.
Zolotarev
Iu A
IuA
Badmaeva
K E
KE
Bakaeva
Z V
ZV
Samonina
G E
GE
Kopylova
G N
GN
Dadaian
A K
AK
Zverkov
Iu B
IuB
Garanin
S K
SK
Vas'kovskiĭ
B V
BV
Ashmarin
I P
IP
Miasoedov
N F
NF
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000737:chemistry*; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects; D006868:Hydrolysis; D008297:Male; D010446:Peptide Fragments / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013315:Stress, Psychological / Q000150:complications
D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D000431:Ethanol; D003094:Collagen