[Crohn's disease associated with IgA nephropathy].
Crohn's disease is a condition of chronic inflammation potentially involving any location of the alimentary tract from mouth to anus. Numerous extraintestinal manifestations can also be present. Urologic complications of inflammatory bowel disease are seen in up to 25% of patients, but renal parenchymal disease has been rarely reported. IgA nephropathy is recognized worldwide as a most common form of primary glomerulonephritis. Clinical manifestations vary, ranging from microscopic hematuria to nephrotic syndrome. Recently, IgA nephropathy associated with systemic diseases has been reported. We describe a case of a 22 year-old man with Crohn's disease associated with IgA nephropathy. At the age of 8 years, microscopic hematuria appeared. After fourteen years, he presented with melena, mild fever, recurrent oral ulcer, microscopic hematuria and proteinuria. Colonoscopic examination revealed characteristic features of Crohn's disease such as multiple ulcers. Microscopic findings showed superficial ulceration with small noncaseating granulomas. Renal biopsy revealed IgA nephropathy. The patient was treated with oral prednisolone, olsalazine, and metronidazole followed by maintenance therapy with sulfasalazine and azathioprine resulting in clinical improvement of Crohn's disease and IgA nephropathy.
Youm
Ji Youn
JY
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Lee
Oh Young
OY
Park
Moon Hyang
MH
Yang
Sun Young
SY
Han
Sung Hee
SH
Baek
Yoo Hum
YH
Park
Song Ree
SR
Lee
Hang Lack
HL
Yoon
Byoung Chul
BC
Choi
Ho Soon
HS
Hahm
Joon Soo
JS
Lee
Min Ho
MH
Lee
Dong Hoo
DH
Kee
Chun Suk
CS
D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male