title: Hippocampus function predicts severity of post-traumatic stress disorder.
abstract: Post-traumatic stress disorder (PTSD) is often accompanied by memory problems and abnormal brain structure, particularly within the hippocampus. We implemented a cross-species, hippocampal-dependent task--the virtual Morris Water task--to assess hippocampal function in people with PTSD and age-matched controls during functional magnetic resonance imaging (fMRI). Performance on the task was equivalent between the groups. However, when correlating fMRI-derived hippocampal activity during this task with PTSD severity, we observe a -0.84 correlation, indicating that those with reduced hippocampal activity show more severe PTSD symptoms. This correlation is not explained by differences in task performance, IQ, duration since trauma, nor time with PTSD. Hence, PTSD severity is predicted by functionally assessing the hippocampus using the virtual Morris water task, suggesting that this task may be used to identify those at risk for developing PTSD following a trauma.
authors.affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA. rastur@harthosp.org
authors.forename: Robert S
authors.initials: RS
authors.lastname: Astur
authors.forename: Sarah A
authors.initials: SA
authors.lastname: St Germain
authors.forename: David
authors.initials: D
authors.lastname: Tolin
authors.forename: Julian
authors.initials: J
authors.lastname: Ford
authors.forename: David
authors.initials: D
authors.lastname: Russell
authors.forename: Mike
authors.initials: M
authors.lastname: Stevens
mesh_terms: D001931:Brain Mapping; D003198:Computer Simulation; D005071:Evoked Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D016555:Matched-Pair Analysis; D018782:Maze Learning / Q000502:physiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000503:physiopathology; D014584:User-Computer Interface