title: Organocatalytic conjugate addition of malonates to alpha,beta-unsaturated aldehydes: asymmetric formal synthesis of (-)-paroxetine, chiral lactams, and lactones.
authors.affiliation: The Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
authors.forename: Sven
authors.initials: S
authors.lastname: Brandau
authors.forename: Aitor
authors.initials: A
authors.lastname: Landa
authors.forename: Johan
authors.initials: J
authors.lastname: Franzén
authors.forename: Mauro
authors.initials: M
authors.lastname: Marigo
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000928:Antidepressive Agents / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017374:Paroxetine / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000928:Antidepressive Agents; D007769:Lactams; D007783:Lactones; D008314:Malonates; D012997:Solvents; D017374:Paroxetine