title: Transplantation of bone marrow derived progenitor cells in acute myocardial infarction. The first results.
abstract: The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in two patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.
authors.affiliation: Charles University Prague, 1st Department of Medicine, Faculty of Medicine, Hradec Králové and University Hospital Hradec Králové, Czech Republic. pudilradek@yahoo.com
authors.forename: Radek
authors.initials: R
authors.lastname: Pudil
authors.forename: Jan
authors.initials: J
authors.lastname: Vojádek
authors.forename: Stanislav
authors.initials: S
authors.lastname: Filip
authors.forename: Pavel
authors.initials: P
authors.lastname: Mericka
authors.forename: Josef
authors.initials: J
authors.lastname: St'ásek
authors.forename: Hana
authors.initials: H
authors.lastname: Straková
authors.forename: Doris
authors.initials: D
authors.lastname: Vokurková
authors.forename: Miroslav
authors.initials: M
authors.lastname: Solar
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Mokrý
authors.forename: Jan
authors.initials: J
authors.lastname: Dominik
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Malý
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology; D012038:Regeneration; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left