title: Beta3-adrenergic stimulation in the human heart: signal transduction, functional implications and therapeutic perspectives.
abstract: Next to beta1- and beta2-adrenoceptors, a third beta-adrenoceptor population is expressed in the human heart, the beta3-adrenoceptor. In mammalian ventricular myocytes, beta3-adrenergic stimulation leads to a decrease in contractility via a release of nitric oxide (NO). Recently, different molecular mechanisms of beta3-adrenergic activation of endothelial nitric oxide synthase (eNOS) have been uncovered in cardiac myocytes. In the non-failing and especially the failing heart, beta3-adrenergic stimulation may offer protection against excessive catecholaminergic beta1-adrenoceptor stimulation. In this context, the beta3-adrenoceptor is discussed as a novel target for the pharmacological therapy of heart failure.
authors.affiliation: Laboratory for Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pott
authors.forename: K
authors.initials: K
authors.lastname: Brixius
authors.forename: W
authors.initials: W
authors.lastname: Bloch
authors.forename: C
authors.initials: C
authors.lastname: Ziskoven
authors.forename: A
authors.initials: A
authors.lastname: Napp
authors.forename: R H G
authors.initials: RH
authors.lastname: Schwinger
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000188:drug therapy*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D013268:Stimulation, Chemical
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists