The oxidative mannich reaction catalyzed by dirhodium caprolactamate.
Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C-H oxidation of a tertiary amine followed by nucleophilic capture. This green transformation is conducted in protic solvent using inexpensive T-HYDRO (70% t-BuOOH in water). Synthetically valuable gamma-aminoalkyl butenolides are obtained.
Catino
Arthur J
AJ
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Nichols
Jason M
JM
Nettles
Brian J
BJ
Doyle
Michael P
MP
D002384:Catalysis; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
D012238:Rhodium