title: Mesh erosion in abdominal sacral colpopexy with and without concomitant hysterectomy.
abstract: OBJECTIVE
  The purpose of this study was to examine risk factors for mesh erosion, including concomitant hysterectomy, in abdominal sacral colpopexies.
  
  
  METHODS
  We conducted a retrospective cohort study of 313 women who underwent an abdominal sacral colpopexy. Data regarding patient demographics, operative techniques, length of follow-up, postoperative complications, and mesh erosion were collected.
  
  
  RESULTS
  Of 313 subjects, 101 (32.3%) had concomitant hysterectomies and 212 (67.7%) had had previous hysterectomies. The overall rate of mesh erosion was 5.4%. In bivariate analysis, concomitant hysterectomy was not associated with erosion (6.9% vs 4.7% previous hysterectomy, P = .42); however, estrogen therapy was an effect modifier. In women on estrogen, hysterectomy (OR 4.9, CI 1.2-19.7) and anterior imbrication (OR 5.6, CI 1.1-28.6) were associated with mesh erosion. No risk factors were identified in women not on estrogen.
  
  
  CONCLUSIONS
  In women on estrogen therapy, hysterectomy was associated with mesh erosion in abdominal sacral colpopexy.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Wu
authors.forename: Ellen C
authors.initials: EC
authors.lastname: Wells
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Hundley
authors.forename: Annamarie
authors.initials: A
authors.lastname: Connolly
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Williams
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Visco
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004868:Equipment Failure; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013526:Surgical Mesh / Q000009:adverse effects*; D016019:Survival Analysis; D013536:Suture Techniques; D014596:Uterine Prolapse / Q000601:surgery*