Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues.
Seven known abietane diterpenoids and 11-O- and 12-O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.
Aoyagi
Yutaka
Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Takahashi
Yoshinao
Y
Satake
Yudai
Y
Takeya
Koichi
K
Aiyama
Ritsuo
R
Matsuzaki
Takeshi
T
Hashimoto
Shusuke
S
Kurihara
Teruo
T
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019686:Lamiaceae / Q000737:chemistry*; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D045784:Abietanes