Beating the heat: A translation factor and an RNA mobilize the heat shock transcription factor HSF1.
Cells respond to stress via orchestrated modifications in gene expression; in a recent publication in Nature, Shamovsky et al. (2006) report that an RNA and a translation factor regulate the activity of a transcriptional activator essential to the mammalian heat shock response.
Kugel
Jennifer F
JF
Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, Colorado 80309, USA.
Goodrich
James A
JA
D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D019281:Dimerization; D005786:Gene Expression Regulation; D000076249:Heat Shock Transcription Factors; D018869:Heat-Shock Response / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D020648:Peptide Elongation Factor 1 / Q000378:metabolism; D011487:Protein Conformation; D022661:RNA, Untranslated / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D000076249:Heat Shock Transcription Factors; C490017:Hsf1 protein, mouse; D020648:Peptide Elongation Factor 1; D022661:RNA, Untranslated; D015534:Trans-Activators; D014157:Transcription Factors