title: [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].
abstract: Experimental and theoretical demonstration of different effect of certain regulatory peptides (RPs) on blood coagulation is available. The problem of the role of RPs in hemostatic processes becomes particularly significant since, first, the peptides are widespread in nature both in animal and plant tissues, second, there is a relationship between the peptide structure and function and, third, both natural and synthetic peptides are used in practical medicine to correct functions of some factors of the hemostatic system. Many peptide inhibitors of the primary and plasma hemostasis potentiating anticoagulant effects in the body have been described.
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Obergan
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology; D011392:Proline / Q000032:analysis
chemical_list: D000925:Anticoagulants; D004151:Dipeptides; D009842:Oligopeptides; D010446:Peptide Fragments; C015248:glycylproline; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D011392:Proline; C100827:TP 7