B-type natriuretic peptide and arterial stiffness in healthy Japanese men.
BACKGROUND
Recent evidence suggests that even a slight increase in the plasma level of B-type natriuretic peptide (BNP) may be a marker of cardiovascular risk; however, the mechanisms underlying the association are currently unclear. Because increased arterial stiffness, as reflected by an increase of the pulse wave velocity (PWV) or pulse pressure (PP), may contribute to increasing plasma BNP levels, in the present study we investigated the relationships between the plasma BNP level and the PWV and PP, all of which are known markers of cardiovascular risk, in a healthy male Japanese cohort.


METHODS
This was a cross-sectional study of 725 healthy Japanese men (age, 54 +/- 4 years). The PWV was assessed by the volume-rendering method. Plasma BNP levels were determined with a high-sensitivity noncompetitive immunoradiometric assay.


RESULTS
A univariate linear regression analysis demonstrated that the plasma BNP level was significantly correlated with age (r = 0.20, P < .01), PWV (r = 0.12, P < .01), and PP (r = 0.17, P < .01). A stepwise multivariate linear regression analysis demonstrated that both the PWV and PP were significantly associated with the plasma BNP level, independent of age.


CONCLUSIONS
In healthy Japanese men, stiffening of large arteries, as evidenced by an increase of the PWV or PP, may account at least in part for elevated plasma BNP levels, even within the so-called normal range.
Yambe
Minoru
M
Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
Tomiyama
Hirofumi
H
Koji
Yutaka
Y
Motobe
Kohki
K
Shiina
Kazuki
K
Gulnisia
Zaydun
Z
Yamamoto
Yoshio
Y
Yamashina
Akira
A
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure; D001916:Brachial Artery / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology; D003430:Cross-Sectional Studies; D006801:Humans; D015592:Immunoradiometric Assay; D007564:Japan; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012016:Reference Values; D012307:Risk Factors; D014655:Vascular Resistance / Q000502:physiology*
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain