title: Histone mediated gene activation in Toxoplasma gondii.
abstract: DNA processes, including transcriptional activation, are largely governed by histone modifications. For most eukaryotes, chromatin-remodeling machines have been identified that move, replace, or decorate histones. Recent studies have shed some important light on similar machinery operating in apicomplexan parasites, including the opportunistic pathogen Toxoplasma gondii. Here we present a synthesis of the current knowledge of histone mediated gene expression in Toxoplasma, particularly in the context of parasite differentiation.
authors.affiliation: Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS A-525, Indianapolis, IN 46202, USA. wjsulliv@iupui.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Sullivan
authors.forename: Mohamed-Ali
authors.initials: MA
authors.lastname: Hakimi
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism; D014122:Toxoplasma / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D006657:Histones; D015800:Protozoan Proteins