title: Detection of residual infarct-related coronary artery stenosis and multivessel disease after thrombolysis: comparison between myocardial contrast echocardiography and single photon emission computed tomography.
abstract: BACKGROUND
  Detection of residual infarct-related artery (IRA) stenosis and multivessel disease (MVD) after thrombolysis has important therapeutic and prognostic implications. Technetium 99m sestamibi single photon emission computed tomography (SPECT) is used for detection of flow-limiting coronary artery disease (CAD). Myocardial contrast echocardiography (MCE) is a new technique developed to assess CAD. We aimed to compare the relative accuracy of vasodilator stress MCE and SPECT for detection of IRA stenosis and MVD after acute myocardial infarction.
  
  
  METHODS
  Accordingly, 72 patients underwent simultaneous MCE and SPECT 7 +/- 2 days after thromobolysis. Coronary angiography was performed in all patients.
  
  
  RESULTS
  Of the 72 patients, 60 demonstrated significant myocardial viability of which 55 (92%) showed significant IRA stenosis (> 50%). MVD was present in 30 (42%) of the 72 patients. MCE was more accurate than SPECT for detection of both IRA stenosis (85% vs 62%, P = .02) and MVD (85% and 64%, P = .004).
  
  
  CONCLUSIONS
  MCE was comparable to SPECT for the detection of IRA stenosis and MVD after thrombolysis.
authors.affiliation: Department of Cardiovascular Medicine, Northwick Park Hospital, Middlesex, United Kingdom.
authors.forename: Girish
authors.initials: G
authors.lastname: Dwivedi
authors.forename: Rajesh
authors.initials: R
authors.lastname: Janardhanan
authors.forename: Sajad
authors.initials: S
authors.lastname: Hayat
authors.forename: Roxy
authors.initials: R
authors.lastname: Senior
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015912:Thrombolytic Therapy; D015899:Tomography, Emission-Computed, Single-Photon; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi