title: Social stress alters the severity and onset of the chronic phase of Theiler's virus infection.
abstract: Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.
authors.affiliation: Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, College Station, 77843-4235, USA. R8obin@earthlink.net
authors.forename: Robin R
authors.initials: RR
authors.lastname: Johnson
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Prentice
authors.forename: Patrick
authors.initials: P
authors.lastname: Bridegam
authors.forename: Colin R
authors.initials: CR
authors.lastname: Young
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Steelman
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Welsh
authors.forename: C Jane R
authors.initials: CJ
authors.lastname: Welsh
authors.forename: Mary W
authors.initials: MW
authors.lastname: Meagher
mesh_terms: D000208:Acute Disease; D000818:Animals; D001522:Behavior, Animal; D018188:Cardiovirus Infections / Q000175:diagnosis / Q000276:immunology / Q000523:psychology*; D002908:Chronic Disease; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000276:immunology / Q000523:psychology* / Q000821:virology; D012720:Severity of Illness Index; D012919:Social Behavior; D013315:Stress, Psychological / Q000175:diagnosis* / Q000276:immunology / Q000523:psychology / Q000821:virology; D017945:Theilovirus / Q000276:immunology