Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis.
OBJECTIVE
To report a case of peripheral interstitial keratitis in a patient with mastocytosis.


METHODS
Clinical case description and immunohistologic examination of biopsied ocular tissue.


RESULTS
A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching. Biomicroscopy of the cornea showed deep corneal inflammatory infiltrates and midstromal vascularization adjacent to a region of superior bulbar conjunctiva, which was mildly chemotic and inflamed. Topical mast cell stabilizers and a short course of topical steroids produced dramatic resolution of the lesion. Biopsy of the erythematous conjunctiva adjacent to the area of corneal inflammation showed the presence of mast cells.


CONCLUSIONS
This is the first case of corneal inflammatory infiltration in a patient with mastocytosis. Therapy for this condition consists of a combination of topical mast cell stabilizers, topical steroids, and systemic antihistaminic therapy.
Magone
M Teresa
MT
Cornea Service, Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143-0730, USA.
Maric
Irina
I
Hwang
David G
DG
D000328:Adult; D016510:Corneal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003319:Corneal Stroma / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008407:Mast Cells / Q000473:pathology; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D014582:Urticaria Pigmentosa / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D005938:Glucocorticoids; D006633:Histamine Antagonists; D011725:Pyridines; D011744:Pyrimidinones; C055139:pemirolast; C009935:prednisolone acetate; D011239:Prednisolone