[Acyclovir combined with plasma exchange for disseminated varicella-zoster virus infection after bone marrow transplantation].
In 2001, a 45-year-old man with severe aplastic anemia received a bone marrow transplantation from his HLA-identical sister, 2.5 years after which he developed severe liver dysfunction together with abdominal pain, disturbance of consciousness and generalized vesicles. Disseminated varicella-zoster virus infection was diagnosed by the detection of VZV DNA. Acyclovir and plasma exchange rapidly controlled his VZV-related symptoms and signs. Disseminated VZV infection is often fatal, but acyclovir and plasma exchange may be useful for such infection by reducing the circulating viral load.
Lee
Chunyong
C
Department of Hematology, Juntendo University, Shizuoka Hospital.
Koike
Michiaki
M
Oshimi
Kazuo
K
Terakura
Seitarou
S
Kodera
Yositaka
Y
D000212:Acyclovir / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000628:therapy; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003131:Combined Modality Therapy; D006562:Herpes Zoster / Q000209:etiology / Q000628:therapy*; D014645:Herpesvirus 3, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange
D000998:Antiviral Agents; D000212:Acyclovir