title: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor.
abstract: Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor. One patient had multiple bones involved. Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma. A review of the English language medical literature yielded only one other reported case with similar features. The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity. The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.
authors.affiliation: Division of Surgical Pathology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. mkyriakos@path.wustl.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Kyriakos
authors.forename: Georges Y
authors.initials: GY
authors.lastname: El-Khoury
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: McDonald
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Buckwalter
authors.forename: Murali
authors.initials: M
authors.lastname: Sundaram
authors.forename: Barry
authors.initials: B
authors.lastname: DeYoung
authors.forename: Michael P
authors.initials: MP
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007867:Leg Bones / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D018215:Osteoblastoma / Q000175:diagnosis* / Q000473:pathology; D010017:Osteoma, Osteoid / Q000175:diagnosis; D019043:Vascular Neoplasms / Q000175:diagnosis