title: Stereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mould.
abstract: Dimeric indole alkaloid, anhydrovinblastine, which can be obtained from catharanthine and vindoline in a high yield, was converted stereoselectively into vinblastine through alternating oxidation-reduction with oxygen and NaBH(3)CN in the presence of anti-vinblastine monoclonal antibody.
authors.affiliation: Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shirahama
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Kohno
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaijima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Morimoto
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Hirata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uesato
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D001894:Borohydrides; D002851:Chromatography, High Pressure Liquid; D006825:Hybridomas; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology; D012710:Serum Albumin, Bovine; D013237:Stereoisomerism; D013954:Thyroglobulin / Q000737:chemistry; D014747:Vinblastine / Q000037:antagonists & inhibitors / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D000972:Antineoplastic Agents, Phytogenic; D001894:Borohydrides; D007202:Indicators and Reagents; D012710:Serum Albumin, Bovine; D014747:Vinblastine; C025364:sodium borohydride; D013954:Thyroglobulin; D010100:Oxygen