5-alkylresorcinols from Merulius incarnatus.
Two new, 5-heptadeca-8'Z,11'Z,16-trienylresorcinol (1) and 5-heptadeca-9'E,11'Z,16-trienylresorcinol (2), and six known 5-alkylresorcinols (3-8) were isolated from the mushroom Merulius incarnatus. Compound 2 is the first 5-alkylresorcinol derivative that contains a trans-cis conjugated double bond system. Compounds 1, 2, 5, 6, 7, and 8 were found to inhibit methacillin-resistant Staphylococcus aureus (MRSA) with IC(50) values of 2.5, 15, 9.5, 8.0, 5.0, and 6.5 microg/mL, respectively. Compound 1 was also active against leishmania, with an IC(50) value of 3.6 microg/mL, and showed no cytotoxicity in our Vero cell test up to a concentration of 25 microg/mL. The structures of these isolates were determined by spectroscopic data including 1D and 2D NMR.
Jin
Wentao
W
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
Zjawiony
Jordan K
JK
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002522:Chlorocebus aethiops; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014709:Vero Cells
C511035:5-heptadeca-8'Z,11'Z,16-trienylresorcinol; C511036:5-heptadeca-9'E,11'Z,16-trienylresorcinol; D000890:Anti-Infective Agents; D012118:Resorcinols