An immunoprecipitation assay for the detection of onconeural antibodies.
BACKGROUND
Onconeural antibodies are found in some patients with cancer, and are associated with paraneoplastic neurological syndromes.


METHODS
A multi-well adapted fluid-phase immunoassay using radiolabelled recombinant onconeural proteins for the detection of onconeural antibodies is described.


CONCLUSIONS
This immunoprecipitation technique is more sensitive in detecting onconeural antibodies than immunohistochemistry and immune blots.
Monstad
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Department of Neurology, Haukeland University Hospital; Department of Clinical Medicine, University of Bergen, Norway. sissel.monstad@helse_bergen.no
Vedeler
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CA
D000912:Antibodies, Neoplasm / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D047468:Immunoprecipitation / Q000379:methods*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000276:immunology*; D012680:Sensitivity and Specificity
D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D009419:Nerve Tissue Proteins