Detection of artifacts and peptide modifications in liquid chromatography/mass spectrometry data using two-dimensional signal intensity map data visualization.
We demonstrate how visualization of liquid chromatography/mass spectrometry data as a two-dimensional signal intensity map can be used to assess the overall quality of the data, for the identification of polymer contaminants and artifacts, as well as for the confirmation of post-translational modifications.
Berg
Matthias
M
GE Healthcare, Oskar Schlemmer Str. 11, D-80807 München, Germany. matthias.berg@ge.com
Parbel
Axel
A
Pettersen
Harald
H
Fenyö
David
D
Björkesten
Lennart
L
D000465:Algorithms; D000595:Amino Acid Sequence; D016477:Artifacts; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D011499:Protein Processing, Post-Translational
D010455:Peptides