Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation.
Nonmyeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis of reproductive function. To address the question of reproductive function after nonmyeloablative transplantation, we analyzed a cohort of young dogs with the genetic disease canine leukocyte adhesion deficiency that were treated with a nonmyeloablative dose of 200 cGy total body irradiation followed by matched-littermate SCT. Five males and 5 females entered puberty; all 5 males and 4 females subsequently sired or delivered litters following transplantation. We demonstrate that fertility is intact and dogs have uncomplicated parturitions following nonmyeloablative conditioning for SCT. These results are encouraging for children and adults of childbearing age who receive similar conditioning regimens prior to allogeneic transplantation.
Burkholder
Tanya H
TH
Division of Veterinary Resources, Office of Research Services, National Institutes of Health, 9000 Rockville Pike, Bldg 28, Rm 104, Bethesda, MD 20892-0001, USA. burkholt@mail.nih.gov
Colenda
Lyn
L
Tuschong
Laura M
LM
Starost
Matthew F
MF
Bauer
Thomas R
TR
Hickstein
Dennis D
DD
D000818:Animals; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004971:Estrus / Q000502:physiology*; D005260:Female; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D013076:Sperm Count; D013081:Sperm Motility; D033581:Stem Cell Transplantation / Q000662:veterinary*; D014184:Transplantation, Homologous