Special considerations for functional magnetic resonance imaging of pediatric populations.
Functional MRI (fMRI) provides a noninvasive means of studying both typical and atypical brain development in vivo. However, the developmental and clinical status of the populations of interest impact how neuroimaging data should be collected, analyzed, and interpreted. In the present work, we review methodological and theoretical issues relevant to developmental and clinical neuroimaging research and provide possible approaches for addressing each. These issues include accounting for differences in biological noise, neuroanatomy, motion, and task performance. Finally, we emphasize the importance of a converging methods approach in constraining and supporting interpretations of pediatric imaging results.
Kotsoni
Eleni
E
Sackler Institute for the Developmental Psychobiology, Weill Medical College of Cornell University, Ithaca, New York 10021, USA.
Byrd
Dana
D
Casey
B J
BJ
D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009422:Nervous System Diseases / Q000175:diagnosis*; D010372:Pediatrics / Q000379:methods*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'