title: [Effects of inosine injection in expression of myosin heavy chain in intrafusal and extrafusal myofibers in soleus muscle of tail-suspended rats].
abstract: OBJECTIVE
  To study the effects of inosine on myosin heavy chain (MHC) activity in rats soleus muscle after tail-suspension.
  
  
  METHODS
  Weightlessness was simulated by tail-suspension of rats. Using immunohistochemistry technique, changes of expression of MHC in intrafusal and extrafusal fibers in soleus muscle were detected.
  
  
  RESULTS
  Expression of fast MHC in intrafusal and extrafusal fibers in soleus muscle increased after 14 d of simulated weightlessness, whereas in tail-suspended rats given inosine, the expression of fast MHC was not detected.
  
  
  CONCLUSIONS
  Inosine could counteract the changes in expression of MHC in intrafusal and extrafusal fibers of rats soleus under simulated weightless situation.
authors.affiliation: Department of Physical Education, Xi'an 710061, China. shilei@mail.xjtu.edu.cn
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Fan
authors.forename: Su-di
authors.initials: SD
authors.lastname: Wu
mesh_terms: D000818:Animals; D015870:Gene Expression; D019417:Hindlimb Suspension; D007267:Injections; D007288:Inosine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation
chemical_list: D007288:Inosine; D018995:Myosin Heavy Chains