A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy.
We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy. She underwent a thymectomy at 40 years of age to treat myasthenia gravis. PRCA developed 3 years after the thymectomy and she was successfully treated with cyclosporin. Systemic lupus erythematosus and IPH were diagnosed 6 years later. We conclude that immunological dysfunction resulting from the thymectomy contributed significantly to the subsequent development of PRCA, SLE, and IPH in this patient. This is the first report to describe this extremely rare occurrence.
Iwadate
Haruyo
H
Department of Internal Medicine II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. haru-i@fmu.ac.jp
Kobayashi
Hiroko
H
Shio
Kiori
K
Noguchi
Etsuko
E
Watanabe
Kenya
K
Sasajima
Tomomi
T
Sekine
Hideharu
H
Watanabe
Hiroshi
H
Ohira
Hiromasa
H
Obara
Katsutoshi
K
Sato
Yukio
Y
D000328:Adult; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D009157:Myasthenia Gravis / Q000601:surgery*; D011183:Postoperative Complications; D011239:Prednisolone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015911:Sclerotherapy; D013934:Thymectomy / Q000009:adverse effects*; D016896:Treatment Outcome
D011239:Prednisolone