Can childhood trauma predict response to topiramate in borderline personality disorder?
We report on a woman with borderline personality disorder and a history of childhood trauma that showed significant clinical response with low dosage of topiramate. We propose that topiramate changed some of the main features of this disorder, such as catastrophic reaction to real or imaginary abandonment or rejection, improving adaptive functioning. We hypothesize that topiramate might facilitate memory extinction, therefore decreasing emotional and behavioural reactivity.
do Prado-Lima
P A S
PA
Behavioral Neurobiology Research Group-- Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. paspl@uol.com.br
Kristensen
C H
CH
Bacaltchuck
J
J
D001883:Borderline Personality Disorder / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002649:Child Abuse; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D000077236:Topiramate
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose