title: The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis.
abstract: OBJECTIVE
  Chronic pancreatitis (CP) is an inflammatory process initiated by recurrent acute pancreatitis and characterized by progressive parenchyma destruction and fibrosis. Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP.
  
  
  METHODS
  A genetic association study was performed on 177 CP patients and 116 healthy controls from the NAPS2 Study. The MCP-1 A/G genotype was determined by RFLP and confirmed by DNA sequencing.
  
  
  RESULTS
  Compared to the control group the MCP-1 -2518 genotypes were similar: A/A (57% vs. 50%), A/G (34.5% vs. 40%) and G/G (8.5% vs. 10%). These allele frequencies were not statistically different (p = 0.267).
  
  
  CONCLUSIONS
  Although the pro-inflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP.
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Sass
authors.forename: Georgios I
authors.initials: GI
authors.lastname: Papachristou
authors.forename: Janette
authors.initials: J
authors.lastname: Lamb
authors.forename: M Michael
authors.initials: MM
authors.lastname: Barmada
authors.forename: Randall E
authors.initials: RE
authors.lastname: Brand
authors.forename: Mary E
authors.initials: ME
authors.lastname: Money
authors.forename: Robert H
authors.initials: RH
authors.lastname: Hawes
authors.forename: Peter B
authors.initials: PB
authors.lastname: Cotton
authors.forename: Adam
authors.initials: A
authors.lastname: Slivka
authors.forename: David C
authors.initials: DC
authors.lastname: Whitcomb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D018932:Chemokine CCL2