title: The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.
abstract: BACKGROUND
  Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, whereas a following study showed no association in a sample of suicide attempters.
  
  
  METHODS
  The involvement of the implicated G-allele of the 5-HTR1A C(-1019)G polymorphism (rs6295) was analyzed with the transmission disequilibrium test (TDT) in a sample of 272 suicide attempter families.
  
  
  RESULTS
  No overtransmission of the G-allele was found in the entire sample of suicide attempters (p = 0.1460; n = 272 trios). However, a strong trend for overtransmission of the G-allele was observed in a sub-sample selected for a high level of previous traumatic and/or stressful life events prior to the suicide attempt (p = 0.0630, two-tail; n = 94 trios).
  
  
  CONCLUSIONS
  The current results show that variation at the rs6295 polymorphism of the HTR1A gene is not associated with suicide attempts generally. However, the results indicate a possible role of the G-allele in suicidal behavior in connection with high exposure to traumatic and/or stressful life events, which is in need of future investigation.
authors.affiliation: The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health (NASP), Dep, of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden. danuta.wasserman@ki.se
authors.forename: Danuta
authors.initials: D
authors.lastname: Wasserman
authors.forename: Thomas
authors.initials: T
authors.lastname: Geijer
authors.forename: Marcus
authors.initials: M
authors.lastname: Sokolowski
authors.forename: Vsevolod
authors.initials: V
authors.lastname: Rozanov
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wasserman