title: Comparative oral toxicity of coenzyme Q10 and its (2Z)-isomer in rats: single and four-week repeated dose toxicity studies.
abstract: It has been reported that coenzyme Q10 (CoQ10) functions as an electron transfer carrier in mitochondria, and can produce an improvement in heart diseases such as congestive heart failure. Its (2Z)-isomer contains a cis-double bond at the 2-position of the decaprenyl side chain. As the original organic industrial synthesis of CoQ10 resulted in a product that contained a small amount of this isomer, the efficacy and safety of CoQ10 was determined using CoQ10 containing this isomer; however, no toxicity data have been reported for the (2Z)-isomer itself. Thus, we conducted single (2,000 mg/kg) and 4-wk repeated (1,000 mg/kg) oral dose toxicity studies in rats to compare the toxicological profiles of CoQ10 and its (2Z)-isomer. The two compounds displayed similar toxicological profiles, and it was concluded that neither CoQ10 nor its (2Z)-isomer produce toxic effects in rats in single or repeated doses.
authors.affiliation: Nisshin Kyorin Pharmaceutical Co Ltd, Tokyo, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kawase
authors.forename: Ikuo
authors.initials: I
authors.lastname: Yoshimura
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003067:Coenzymes; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010976:Platelet Count; D010994:Pleura / Q000473:pathology; D011507:Proteinuria; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D014556:Urine
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10