When a motor goes bad: a kinesin regulates neuronal survival.
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose) polymerase-1 in an unexpected way.
Kaplan
David R
DR
Cancer Research and Developmental Biology, Hospital for Sick Children Research Institute, Department of Molecular, University of Toronto, Ontario, Canada M5G 1X8. dkaplan@sickkids.ca
Miller
Freda D
FD
D000818:Animals; D002470:Cell Survival; D016547:Kinesins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D009419:Nerve Tissue Proteins; C499321:Parp1 protein, mouse; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; C089655:Kif4 protein, mouse; D016547:Kinesins