title: A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.
abstract: Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.
authors.affiliation: Department of Pathology, and Microbiology & Immunology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.forename: Steven H L
authors.initials: SH
authors.lastname: Verhelst
authors.forename: Galia
authors.initials: G
authors.lastname: Blum
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Coussens
authors.forename: Matthew
authors.initials: M
authors.lastname: Bogyo
mesh_terms: D000818:Animals; D020789:Cathepsin C / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D015335:Molecular Probes
chemical_list: D015335:Molecular Probes; D020789:Cathepsin C