title: Lignans from Saussurea conica and their NO production suppressing activity.
abstract: Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Xing-Zu
authors.initials: XZ
authors.lastname: Zhu
authors.forename: Zha-Jun
authors.initials: ZJ
authors.lastname: Zhan
authors.forename: Xin-Quan
authors.initials: XQ
authors.lastname: Ji
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D030441:Saussurea / Q000737:chemistry*
chemical_list: D017705:Lignans; D009569:Nitric Oxide