IL-2 increased RANTES production and CD25 expression in cultured PBMCs only from antiretroviral treated HIV-1+ patients with detectable viral loads.
In order to better understand the possible beneficial effects of intermittent IL-2 treatment as complement of antiretroviral therapy in HIV-1+ patients, we have measured the levels of RANTES in the supernatants and the CD25 expression in cultured PBMCs obtained from HIV-1+ individuals in presence of IL-2. The results showed a significant increases in RANTES production and in the expression of CD25+ in the cultures with IL-2 of PBMC obtained from HIV-1+ patients with a detectable viral load in comparison with both, HIV-1+ patients with no detectable viral loads and with healthy individuals. These results suggest that therapeutic IL-2 administered in addition to highly active anti-retroviral therapy (HAART) may contribute to increase the effect of this therapy by rising both RANTES production and CD25 expression only in HIV-1+ patients with detectable viral loads.
Lozano
José Manuel
JM
Department of Immunology, Hospital Reina Sofía, University of Cordoba, Spain.
Kindelán
José María
JM
Cabello
Almudena
A
Gonzalez
Rafael
R
Solana
Rafael
R
Peña
José
J
D015703:Antigens, CD / Q000032:analysis / Q000378:metabolism; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000378:metabolism*; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000378:metabolism*; D019562:Viral Load
D015703:Antigens, CD; D018946:Chemokine CCL5; D007376:Interleukin-2; D012367:RNA, Viral; D015375:Receptors, Interleukin-2