title: [Role of urinary basic fibroblast growth factor in differentiating hemangiomas from vascular malformation].
abstract: OBJECTIVE
  To investigate a novel method to differentiate hemangioma from vascular malformation, to stage hemangiomas and to monitor the efficacy of management for hemangioma.
  
  
  METHODS
  The urinary basic fibroblast growth factor (bFGF) concentration of 144 cases (including 69 cases of proliferating hemangiomas, 41 cases of involuting hemangiomas, 23 cases of vascular malformations and 11 negative controls) was examined using enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The differences of urinary bFGF concentration among proliferating hemangiomas, involuting hemangiomas, vascular malformations and negative control were all significant, while the differences between the latter three groups were not significant.
  
  
  CONCLUSIONS
  Our findings suggest that examination of urinary bFGF concentration using ELISA technique is helpful in differentiating hemangioma from vascular malformation, staging hemangiomas and dynamically monitoring the efficacy of treatment for hemangiomas. Our results probably shed new light on the potential pathogenesis of hemangiomas and vascular malformation.
authors.affiliation: Department of Plastic and Reconstructive Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Lin
authors.forename: Zuo-liang
authors.initials: ZL
authors.lastname: Qi
authors.forename: Jia-sheng
authors.initials: JS
authors.lastname: Dong
authors.forename: Li-jian
authors.initials: LJ
authors.lastname: Zou
authors.forename: Chuan-chang
authors.initials: CC
authors.lastname: Dai
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D001165:Arteriovenous Malformations / Q000175:diagnosis* / Q000652:urine; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016222:Fibroblast Growth Factor 2 / Q000652:urine*; D006391:Hemangioma / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D016222:Fibroblast Growth Factor 2