title: Prevalence of dental anomalies, ectopic eruption and associated oral malformations in subjects with Treacher Collins syndrome.
abstract: OBJECTIVE
  To examine the prevalence of dental anomalies in the deciduous and permanent teeth, ectopic eruption of permanent first molars, and associated oral malformations in individuals with Treacher Collins syndrome.
  
  
  METHODS
  Clinical and radiographic examination of 15 patients with Treacher Collins syndrome, from the Hospital for Rehabilitation of Craniofacial Anomalies of the University of São Paulo, not submitted to orthodontic or orthognathic treatment.
  
  
  RESULTS
  Dental anomalies were present in 60% of the sample, with 1-8 anomalies per individual. Hypoplastic dental anomalies were the most common, followed by heterotopic and hyperplastic dental alterations. The most frequent anomalies were tooth agenesis (33.3%), mainly affecting the mandibular second premolars, and enamel opacities (20% of patients). Ectopic eruption of the maxillary first molars was found in 13.3% of subjects. Associated oral malformations, primarily isolated cleft palate, followed by complete cleft lip and palate and macrostomia, were observed in 66.7% of patients.
  
  
  CONCLUSIONS
  Presence of cleft palate associated with the syndrome is in agreement with the literature. The high prevalence of dental anomalies suggests a possible etiologic relationship, not described in the literature so far, between such alterations and the Treacher Collins syndrome. Further investigations on larger samples are required to confirm these results.
authors.affiliation: Public Health Dentistry Sector, Hospital for Rehabilitation of Craniofacial Anomalies of University of São Paulo, Bauru, SP, Brazil. gisdalben@centrinho.usp.br
authors.forename: Gisele
authors.initials: G
authors.lastname: da Silva Dalben
authors.forename: Beatriz
authors.initials: B
authors.lastname: Costa
authors.forename: Marcia Ribeiro
authors.initials: MR
authors.lastname: Gomide
mesh_terms: D000293:Adolescent; D000848:Anodontia / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000209:etiology; D002972:Cleft Palate / Q000209:etiology; D003744:Dental Enamel Hypoplasia / Q000209:etiology; D006801:Humans; D008265:Macrostomia / Q000209:etiology; D008342:Mandibulofacial Dysostosis / Q000150:complications*; D008963:Molar / Q000473:pathology; D014071:Tooth Abnormalities / Q000209:etiology*; D014079:Tooth Eruption, Ectopic / Q000209:etiology*