title: Granulatamides A and B, cytotoxic tryptamine derivatives from the soft coral Eunicella granulata.
abstract: Two new tryptamine derivatives, granulatamides A (1) and B (2), were isolated from the 2-propanol extract of the soft coral Eunicella granulata. Their structures were determined on the basis of detailed spectroscopic analysis and comparison with previously published data for similar compounds. Both compounds showed moderate in vitro cytotoxicity against a panel of 16 human tumor cell lines.
authors.affiliation: Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. jfreyes@pharmamar.com
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.forename: Rocío
authors.initials: R
authors.lastname: Martín
authors.forename: Rogelio
authors.initials: R
authors.lastname: Fernandez
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012675:Senegal; D014363:Tryptamines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014363:Tryptamines; C510714:granulatamide A; C510715:granulatamide B