title: Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats.
abstract: Plasma histamine levels were measured in 11 clinically healthy cats and 15 cats with allergic dermatitis. Histamine levels were markedly elevated in 5/15 allergic cats. A calcium ionophore, A23187, stimulates histamine release from feline peripheral blood cells. Immunostaining of blood smears from clinically healthy cats revealed that approximately 10% of eosinophils possessed histamine-containing granules. These results indicate that some peripheral eosinophils in cats contain histamine and can release histamine by appropriate stimulation.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Kadoya
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Momoi
authors.forename: Toshiroh
authors.initials: T
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002371:Cat Diseases / Q000276:immunology* / Q000473:pathology; D002415:Cats; D017449:Dermatitis, Allergic Contact / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006632:Histamine / Q000097:blood*; D006636:Histamine Release; D008297:Male; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D006632:Histamine