title: The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
abstract: In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
authors.affiliation: Department of Neurology, University of Milano-Bicocca, Monza, Monza, Italy. longonimarco@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Longoni
authors.forename: C
authors.initials: C
authors.lastname: Grond-Ginsbach
authors.forename: A J
authors.initials: AJ
authors.lastname: Grau
authors.forename: J
authors.initials: J
authors.lastname: Genius
authors.forename: S
authors.initials: S
authors.lastname: Debette
authors.forename: M
authors.initials: M
authors.lastname: Schwaninger
authors.forename: C
authors.initials: C
authors.lastname: Ferrarese
authors.forename: C
authors.initials: C
authors.lastname: Lichy
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D005260:Female; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000502:physiology; D008239:Lysine / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020217:Vertebral Artery Dissection / Q000235:genetics*
chemical_list: D018799:Intercellular Adhesion Molecule-1; D018698:Glutamic Acid; D008239:Lysine