title: The polyomavirus, JCV and its involvement in human disease.
abstract: The human neurotropic polyomavirus, JC virus (JCV), is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients. JCV has also been found to be associated with human tumors of the brain and other organs. In this chapter, we describe JC virus and its role in human diseases.
authors.affiliation: Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania, USA.
authors.forename: Kamel
authors.initials: K
authors.lastname: Khalili
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gordon
authors.forename: Martyn K
authors.initials: MK
authors.lastname: White
mesh_terms: D002493:Central Nervous System Diseases / Q000821:virology*; D006801:Humans; D007577:JC Virus / Q000235:genetics / Q000302:isolation & purification*; D011120:Polyomavirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification