Organocatalytic conjugate addition of malonates to alpha,beta-unsaturated aldehydes: asymmetric formal synthesis of (-)-paroxetine, chiral lactams, and lactones.
Brandau
Sven
S
The Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
Landa
Aitor
A
Franzén
Johan
J
Marigo
Mauro
M
Jørgensen
Karl Anker
KA
D000447:Aldehydes / Q000737:chemistry*; D000928:Antidepressive Agents / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017374:Paroxetine / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013237:Stereoisomerism
D000447:Aldehydes; D000928:Antidepressive Agents; D007769:Lactams; D007783:Lactones; D008314:Malonates; D012997:Solvents; D017374:Paroxetine