title: The use of continuous hemodiafiltration in a patient with diabetic ketoacidosis.
abstract: A variety of fatal complications are associated with diabetes mellitus. Among these, diabetic ketoacidosis (DKA) figures largely in fatalities in young diabetics. Although hyperosmotic diuresis in DKA causes extreme fluid loss, acute renal failure is less common than expected in DKA. We treated a case of severe DKA with associated coma, acute respiratory failure, and acute renal failure in a 24-year-old man who had been diagnosed with type 1 diabetes mellitus at age 19. The comatose patient had been intubated before transfer to our hospital for intensive care. Despite infusion with isotonic saline and insulin, metabolic acidosis was refractory. On day 2, urine output decreased and pulmonary congestion developed, so we started continuous veno-venous hemodiafiltration (CVVHDF), which was effective against the metabolic acidosis; urine output increased gradually. CVVHDF was withdrawn on day 7, and the patient's renal function recovered completely. He was discharged from the intensive care unit (ICU) on day 14.
authors.affiliation: Emergency and Critical Care Medicine, Tokushima University Hospital, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kawata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inui
authors.forename: Jun
authors.initials: J
authors.lastname: Ohto
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Miki
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Suzue
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fukuta
authors.forename: Masaji
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000138:Acidosis / Q000628:therapy*; D000328:Adult; D001784:Blood Gas Analysis; D003128:Coma; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000150:complications / Q000628:therapy; D017583:Hemodiafiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy; D014883:Water-Electrolyte Imbalance / Q000628:therapy