title: A novel method to convert triptolide into tripchlorolide in Tripterygium wilfordii.
abstract: A new method has been established to convert triptolide (1) into tripchlorolide (2) directly in the Chinese herbal drug Tripterygium wilfordii Hook F. and the influences of reaction times and pH values have been investigated. It was found that 1 could be most efficiently converted into 2 using a hydrochloric acid-acetic acid system. An HPLC method was devised in order to monitor the conversion and ESI-MS was used to identify the synthetic product 2. The sensitivity of the assay was sufficient to monitor the conversion of the main active components in T. wilfordii.
authors.affiliation: College of Pharmacy, Hebei University, Baoding 071002, People's Republic of China.
authors.forename: Baozhi
authors.initials: B
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Gengliang
authors.initials: G
authors.lastname: Yang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Li
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
mesh_terms: D004224:Diterpenes / Q000737:chemistry*; D004852:Epoxy Compounds; D006863:Hydrogen-Ion Concentration; D010616:Phenanthrenes / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D029757:Tripterygium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C068051:tripchlorolide; C001899:triptolide