[A case of AFP and PIVKA-II producing gastric carcinoma].
A 71-year-old man was admitted to our hospital with edema of the ambilateral crura and liver dysfunction. Serum levels of AFP and PIVKA-II were both abnormally high. An abdominal CT revealed many low density masses in both lobes of the liver. Endoscopic examination and gastric radiography showed a Type 1 tumor in the fornix of the stomach. Biopsy specimen showed poorly differentiated adenocarcinoma. Immunohistochemical stains demonstrated the presence of AFP and PIVKA-II in tumor cells. A diagnosis of AFP and PIVKA-II producing gastric carcinoma with liver metastasis was made and the internal use of S-1 was started. The result of treatment was determined to be partial response. However, the condition of his entire body gradually worsened and he died of hepatic insufficiency.
Tanaka
Hiroki
H
Department of Gastroenterology, Prefecture Esashi Hospital.
Ishii
Suguru
S
Akutsu
Noriyuki
N
Ohashi
Hirokazu
H
Tokuno
Tetsuya
T
Suzuki
Takashi
T
Okuda
Hiroyuki
H
Shinomura
Yasuhisa
Y
Imai
Kohzoh
K
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000368:Aged; D015415:Biomarkers; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D011498:Protein Precursors / Q000096:biosynthesis*; D011516:Prothrombin / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D015415:Biomarkers; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin