title: Withdrawal symptoms from transdermal fentanyl (TDF) after an allogeneic peripheral blood stem cell transplant (PBSCT).
abstract: A 47-year-old woman who underwent allogenic peripheral blood stem cell transplant developed withdrawal symptoms soon after Fentanyl 25 mcg/h patch was stopped, which has not been reported at this dose. Possible causes, such as the inhibition of CYP3A4 induced by cyclosporine causing elevations of serum fentanyl, are discussed.
authors.affiliation: Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. rtsutsu@nyc.odn.ne.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Hiroe
authors.initials: H
authors.lastname: Kanamori
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Masauzi
mesh_terms: D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D001416:Back Pain / Q000150:complications / Q000188:drug therapy; D016572:Cyclosporine / Q000009:adverse effects; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000209:etiology* / Q000503:physiopathology; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D065607:Cytochrome P-450 Enzyme Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D005283:Fentanyl