N-acetylphenylisoserinates of Lactarius sesquiterpenoid alcohols--cytotoxic, antiviral, antiproliferative and immunotropic activities in vitro.
In the present study a new group of derivatives of both paclitaxel and Lactarius sesquiterpenes, the N-acetylphenylisoserinates of Lactarius sesquiterpenoid alcohols, was tested for antiviral, cytotoxic, antiproliferative and immunotropic activities in vitro. Among the 13 compounds tested two, isolactarorufin 8-[ N-acetyl-(2' R,3' S)-3'-phenylisoserinate] and 3-O-ethylfurandiol 8-[ N-acetyl-(2' R,3' S)-3'-phenylisoserinate] inhibited Herpes simplex virus type 1 (HSV-1) replication at low cytotoxic concentrations. Selectivity indices were: > 12.2 and > 106.4, respectively. Both compounds decreased also the number of cell divisions. Mitotic indices of the cells submitted to these compounds were: 96/2000 and 48/1000, respectively, in comparison with control (169/2000). It seems that the antimitotic action of the compounds may be associated with their antiviral activity. Moreover, isolactarorufin 8-[ N-acetyl-(2' R,3' S)-3'-phenylisoserinate] inhibited PHA-induced T lymphocyte proliferation.
Krawczyk
Ewa
E
Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland. ewakrawczyk@yahoo.com
Kniotek
Monika
M
Nowaczyk
Maria
M
Dzieciatkowski
Tomasz
T
Przybylski
Maciej
M
Majewska
Anna
A
Luczak
Miroslaw
M
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002522:Chlorocebus aethiops; D004951:Esterification; D018259:Herpesvirus 1, Human / Q000187:drug effects; D017239:Paclitaxel / Q000494:pharmacology; D012694:Serine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*; D014709:Vero Cells
D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D012717:Sesquiterpenes; D012694:Serine; D017239:Paclitaxel