Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala.
Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha.
Ramos
Freddy
F
Pharmacognosy Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomashi 1-78, Tokushima 770-8505, Japan.
Takaishi
Yoshihisa
Y
Kawazoe
Kazuyoshi
K
Osorio
Coralia
C
Duque
Carmenza
C
Acuña
Ricardo
R
Fujimoto
Yoshinori
Y
Sato
Mitsunobu
M
Okamoto
Masato
M
Oshikawa
Tetsuya
T
Ahmed
Sharif Uddin
SU
D000114:Acetylene / Q000737:chemistry* / Q000494:pharmacology; D028041:Centella / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry*; D002554:Cerebrosides / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
D002518:Ceramides; D002554:Cerebrosides; D016207:Cytokines; D007166:Immunosuppressive Agents; D000114:Acetylene