Tenascin-C induced signaling in cancer.
Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying signaling mechanisms. How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor immunosurveillance is summarized. Finally, we discuss how the phenotypes of tenascin-C knock-out mice may help define the roles of tenascin-C in tumorigenesis and how this knowledge could be applied to cancer therapy.
Orend
Gertraud
G
Department of Clinical and Biological Sciences, Institute of Biochemistry and Genetics, Center for Biomedicine, DKBW, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland. gertraud.orend@unibas.ch
Chiquet-Ehrismann
Ruth
R
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D015398:Signal Transduction; D019063:Tenascin / Q000502:physiology*
D019063:Tenascin