Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains.
The ability to cope with ongoing neurodegeneration after injury to the central nervous system of mammals differs among strains and depends in part on the animal's ability to manifest a T-cell-mediated protective response. After CNS injury, strain-related differences were observed. Moreover, the post-injury effect of naturally occurring regulatory CD4+CD25+ T cells was found to differ in different strains. In this study, using partially injured optic nerves of Balb/c/OLA and C57BL/6J mice as models, we observed strain-related differences in the T-cell-mediated protection obtained by antigens administered via the nasal route. Active immunization with myelin-related antigens emulsified in complete Freund's adjuvant had a beneficial effect on both strains, whereas mucosal administration of the same antigens was destructive in mice of the Balb/c/OLA strain but protective in C57BL/6J mice.
Lewitus
Gil M
GM
Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Kipnis
Jonathan
J
Avidan
Hila
H
Ben-Nun
Avraham
A
Schwartz
Michal
M
D000281:Administration, Intranasal; D000595:Amino Acid Sequence; D000818:Animals; D002470:Cell Survival / Q000235:genetics; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D018984:Epitopes, T-Lymphocyte / Q000008:administration & dosage / Q000235:genetics / Q000502:physiology*; D007108:Immune Tolerance / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology*; D009410:Nerve Degeneration / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control*; D020221:Optic Nerve Injuries / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
D018984:Epitopes, T-Lymphocyte