title: Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.
abstract: We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.
authors.affiliation: Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. angela.sansone@spcorp.com
authors.forename: Angela
authors.initials: A
authors.lastname: Sansone-Parsons
authors.forename: Gopal
authors.initials: G
authors.lastname: Krishna
authors.forename: Angela
authors.initials: A
authors.lastname: Calzetta
authors.forename: David
authors.initials: D
authors.lastname: Wexler
authors.forename: Bhavna
authors.initials: B
authors.lastname: Kantesaria
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Rosenberg
authors.forename: Marc A
authors.initials: MA
authors.lastname: Saltzman
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005215:Fasting / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole