The anti-inflammatory and anti-nociceptive effects of ethyl acetate fraction of cynanchi paniculati radix.
The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cynanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.
Choi
Jung-Hyun
JH
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Korea.
Jung
Byung-Ha
BH
Kang
Ok-Hwa
OH
Choi
Hyuk Joon
HJ
Park
Pil Sang
PS
Cho
Sun Hee
SH
Kim
Youn-Chul
YC
Sohn
Dong Hwan
DH
Park
Hyun
H
Lee
John Hwa
JH
Kwon
Dong-Yeul
DY
D000085:Acetates; D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid; D002199:Capillary Permeability / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D031105:Cynanchum / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D005557:Formaldehyde; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010147:Pain Measurement / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D000085:Acetates; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D016718:Arachidonic Acid; C007650:ethyl acetate; D010424:Pentobarbital; D019342:Acetic Acid