title: Photodynamic therapy with Verteporfin for vascular leakage from a combined hamartoma of the retina and retinal pigment epithelium.
abstract: This interventional case report describes a patient with a combined hamartoma of the retina and retinal pigment epithelium (RPE), which was treated with photodynamic therapy (PDT) with Verteporfin. A 17-year-old girl presented with a combined hamartoma of the retina and RPE. Progressive decrease in vision due to vascular leakage and macular involvement led to the decision to treat this lesion with PDT. Rapid vascular closure occurred after PDT as confirmed by fundus fluorescein angiography and the clinical appearance gradually improved. However, visual acuity did not improve substantially. PDT with Verteporfin could be considered as a treatment modality for combined hamartomas of the retina and RPE, which demonstrate progressive vascular leakage.
authors.forename: Helena
authors.initials: H
authors.lastname: Cilliers
authors.forename: C Alex
authors.initials: CA
authors.lastname: Harper
mesh_terms: D000293:Adolescent; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D005451:Fluorescein Angiography; D006222:Hamartoma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000473:pathology; D011166:Porphyrins / Q000627:therapeutic use*; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy*; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin