title: An improved synthesis of psammaplin A.
abstract: The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.
authors.affiliation: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Godert
authors.forename: Norman
authors.initials: N
authors.lastname: Angelino
authors.forename: Anna
authors.initials: A
authors.lastname: Woloszynska-Read
authors.forename: Shannon R
authors.initials: SR
authors.lastname: Morey
authors.forename: Smitha R
authors.initials: SR
authors.lastname: James
authors.forename: Adam R
authors.initials: AR
authors.lastname: Karpf
authors.forename: Janice R
authors.initials: JR
authors.lastname: Sufrin
mesh_terms: D045744:Cell Line, Tumor; D019175:DNA Methylation / Q000187:drug effects; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008780:Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004220:Disulfides; D004791:Enzyme Inhibitors; C098378:psammaplin A; D014443:Tyrosine; D008780:Methyltransferases