Hereditary fructose intolerance and celiac disease: a novel genetic association.
OBJECTIVE
Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI).


METHODS
We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients.


RESULTS
Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P<.02).


CONCLUSIONS
The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.
Ciacci
Carolina
C
Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli Federico II, Napoli, Italy.
Gennarelli
Daniela
D
Esposito
Gabriella
G
Tortora
Raffaella
R
Salvatore
Francesco
F
Sacchetti
Lucia
L
D000328:Adult; D000367:Age Factors; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005633:Fructose Intolerance / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D015318:Fructose Metabolism, Inborn Errors / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D009154:Mutation; D010375:Pedigree; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens