title: An instrumented scaffold can monitor loading in the knee joint.
abstract: No technique has been consistently successful in the repair of large focal defects in cartilage, particularly in older patients. Tissue-engineered cartilage grown on synthetic scaffolds with appropriate mechanical properties will provide an implant, which could be used to treat this problem. A means of monitoring loads and pressures acting on cartilage, at the defect site, will provide information needed to understand integration and survival of engineered tissues. It will also provide a means of evaluating rehabilitation protocols. A "sensate" scaffold with calibrated strain sensors attached to its surface, combined with a subminiature radio transmitter, was developed and utilized to measure loads and pressures during gait. In an animal study utilizing six dogs, peak loads of 120N and peak pressures of 11 MPa were measured during relaxed gait. Ingrowth into the scaffold characterized after 6 months in vivo indicated that it was well anchored and bone formation was continuing. Cartilage tissue formation was noted at the edges of the defect at the joint-scaffold interfaces. This suggested that native cartilage integration in future formulations of this scaffold configured with engineered cartilage will be a possibility.
authors.affiliation: Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Arizona, Tucson, AZ, USA. szivek@email.arizona.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Szivek
authors.forename: C L
authors.initials: CL
authors.lastname: Bliss
authors.forename: C P
authors.initials: CP
authors.lastname: Geffre
authors.forename: D S
authors.initials: DS
authors.lastname: Margolis
authors.forename: D W
authors.initials: DW
authors.lastname: DeYoung
authors.forename: J T
authors.initials: JT
authors.lastname: Ruth
authors.forename: A B
authors.initials: AB
authors.lastname: Schnepp
authors.forename: B C
authors.initials: BC
authors.lastname: Tellis
authors.forename: R K
authors.initials: RK
authors.lastname: Vaidyanathan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D015374:Biosensing Techniques; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery*; D004285:Dogs; D007718:Knee Injuries / Q000601:surgery*; D008297:Male; D011091:Polyesters; D019736:Prostheses and Implants; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C041733:poly(1,4-butylene terephthalate)