Efficient computation of the inverse of gametic relationship matrix for a marked QTL.
Best linear unbiased prediction of genetic merits for a marked quantitative trait locus (QTL) using mixed model methodology includes the inverse of conditional gametic relationship matrix (G-1) for a marked QTL. When accounting for inbreeding, the conditional gametic relationships between two parents of individuals for a marked QTL are necessary to build G-1 directly. Up to now, the tabular method and its adaptations have been used to compute these relationships. In the present paper, an indirect method was implemented at the gametic level to compute these few relationships. Simulation results showed that the indirect method can perform faster with significantly less storage requirements than adaptation of the tabular method. The efficiency of the indirect method was mainly due to the use of the sparseness of G-1. The indirect method can also be applied to construct an approximate G-1 for populations with incomplete marker data, providing approximate probabilities of descent for QTL alleles for individuals with incomplete marker data.
Sargolzaei
Mehdi
M
Course of Environmental Management Science, Graduate School of Science and Technology, Niigata 950-2181, Japan. f03m301f@mail.cc.niigata-u.ac.jp
Iwaisaki
Hiroaki
H
Colleau
Jean-Jacques
JJ
D000465:Algorithms; D000483:Alleles; D000818:Animals; D003198:Computer Simulation; D003433:Crosses, Genetic; D005260:Female; D005718:Gametogenesis; D005819:Genetic Markers; D007178:Inbreeding; D008297:Male; D008957:Models, Genetic; D008962:Models, Theoretical; D010375:Pedigree; D040641:Quantitative Trait Loci
D005819:Genetic Markers