Granulatamides A and B, cytotoxic tryptamine derivatives from the soft coral Eunicella granulata.
Two new tryptamine derivatives, granulatamides A (1) and B (2), were isolated from the 2-propanol extract of the soft coral Eunicella granulata. Their structures were determined on the basis of detailed spectroscopic analysis and comparison with previously published data for similar compounds. Both compounds showed moderate in vitro cytotoxicity against a panel of 16 human tumor cell lines.
Reyes
Fernando
F
Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. jfreyes@pharmamar.com
Martín
Rocío
R
Fernandez
Rogelio
R
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012675:Senegal; D014363:Tryptamines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D014363:Tryptamines; C510714:granulatamide A; C510715:granulatamide B