Necrotizing granulomata in the lung preceding colonic involvement in 2 patients with Crohn's disease.
Extraintestinal involvement, including the chest, is common in the late course of Crohn's disease. We describe 2 female patients in whom the course of the disease was unique in two aspects: (1) each had a pulmonary mass with granulomatous inflammation and necrosis, and (2) these findings had preceded the colonic involvement by 5 years. This sequence supports some of the theories on the pathogenesis of Crohn's disease and on its possible relation with sarcoidosis, another idiopathic granulomatous disease.
Shulimzon
Tiberiu
T
Pulmonary Institute, Sheba Medical Center affiliated to Sackler's School of Medicine, Tel Aviv University, Tel Hashomer, Israel. tiberiu.shulimzon@sheba.health.gov.il
Rozenman
Jehudit
J
Perelman
Marina
M
Bardan
Eytan
E
Ben-Dov
Issahar
I
D000328:Adult; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D003424:Crohn Disease / Q000150:complications* / Q000628:therapy; D005260:Female; D006099:Granuloma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009336:Necrosis; D011859:Radiography; D016896:Treatment Outcome