title: Gene-environment interactions in mental disorders.
abstract: Research clearly shows that both nature and nurture play important roles in the genesis of psychopathology. In this paper, we focus on 'gene-environment interaction' in mental disorders, using genetic control of sensitivity to the environment as our definition of that term. We begin with an examination of methodological issues involving gene-environment interactions, with examples concerning psychiatric and neurological conditions. Then we review the interactions in psychiatric disorders using twin, adoption and association designs. Finally, we consider gene-environment interactions in selected neurodevelopmental disorders (autism and schizophrenia).
authors.affiliation: Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA.
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Bar
authors.forename: William S
authors.initials: WS
authors.lastname: Stone
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone