title: Necrotizing granulomata in the lung preceding colonic involvement in 2 patients with Crohn's disease.
abstract: Extraintestinal involvement, including the chest, is common in the late course of Crohn's disease. We describe 2 female patients in whom the course of the disease was unique in two aspects: (1) each had a pulmonary mass with granulomatous inflammation and necrosis, and (2) these findings had preceded the colonic involvement by 5 years. This sequence supports some of the theories on the pathogenesis of Crohn's disease and on its possible relation with sarcoidosis, another idiopathic granulomatous disease.
authors.affiliation: Pulmonary Institute, Sheba Medical Center affiliated to Sackler's School of Medicine, Tel Aviv University, Tel Hashomer, Israel. tiberiu.shulimzon@sheba.health.gov.il
authors.forename: Tiberiu
authors.initials: T
authors.lastname: Shulimzon
authors.forename: Jehudit
authors.initials: J
authors.lastname: Rozenman
authors.forename: Marina
authors.initials: M
authors.lastname: Perelman
authors.forename: Eytan
authors.initials: E
authors.lastname: Bardan
authors.forename: Issahar
authors.initials: I
authors.lastname: Ben-Dov
mesh_terms: D000328:Adult; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D003424:Crohn Disease / Q000150:complications* / Q000628:therapy; D005260:Female; D006099:Granuloma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009336:Necrosis; D011859:Radiography; D016896:Treatment Outcome