title: Phenolic constituents from Perovskia atriplicifolia.
abstract: Perovskoate, an isorinic acid derivative (1) and perovskoside, the catechol derivative (2) have been isolated from the ethyl acetate soluble fraction of the whole plant of Perovskia atriplicifolia and assigned the structure 3(7-hydroxyphenyl)-2-hydroxy propanoic acid; (R)-form, 2-O-(6',7'-dihydroxy-E-cinnamoyl) (1) and 2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol (2). In addition, caffeic acid (3) and ferulic acid (4) have been reported for the first time from this species. The structures of these compounds were assigned on the basis of 1D and 2D NMR techniques. The compound 1 showed significant inhibitory activity against lipoxygenase and weak to moderate activity against cholinesterases.
authors.affiliation: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Shagufta
authors.initials: S
authors.lastname: Perveen
authors.forename: Sher Bahadar
authors.initials: SB
authors.lastname: Khan
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Rasool Bakhsh
authors.initials: RB
authors.lastname: Tareen
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D002109:Caffeic Acids / Q000737:chemistry; D002396:Catechols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007773:Lactates; D019686:Lamiaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C512672:2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol; C512671:3-(4-hydroxyphenyl)-2-hydroxypropanoic acid; D002109:Caffeic Acids; D002396:Catechols; D002800:Cholinesterase Inhibitors; D003373:Coumaric Acids; D007773:Lactates; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D011422:Propionates; C004999:ferulic acid; C040048:caffeic acid