Candidaemia in Europe: epidemiology and resistance.
Despite the widespread use of antifungals for prophylaxis, Candida bloodstream infection (BSI) remains the most frequent life-threatening fungal disease. From an analysis of multi-institutional surveys of Candida BSIs performed in Europe, including the large prospective survey by the European Confederation of Medical Mycology (2089 episodes from seven countries), a limited role of species with decreased susceptibility to azoles in causing BSIs and a low proportion of antifungal resistance was evident. Large prospective epidemiological surveys using common databases are needed to monitor trends in incidence and changes in species distribution, to identify new at-risk patients and to evaluate the impact of the introduction into the market of new antifungal agents.
Tortorano
Anna Maria
AM
Istituto di Igiene e Medicina Preventiva, Università degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy. annamaria.tortorano@unimi.it
Kibbler
Christopher
C
Peman
Javier
J
Bernhardt
Hannelore
H
Klingspor
Lena
L
Grillot
Renee
R
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005060:Europe / Q000453:epidemiology; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology; D006801:Humans
D000935:Antifungal Agents