title: Detection of human chorionic gonadotrophin-beta in serum or urine of prostate cancer patients is of no clinical significance.
abstract: The aim of this study was to prospectively evaluate the potential role of elevated urinary/serum human chorionic gonadotrophin-beta (hCGbeta) in prostate cancer prognosis. 104 patients with newly diagnosed prostate cancers were included; 68 patients had organ-confined, 18 had locally advanced and 18 had metastatic disease. A control group consisted of 115 patients presenting with benign prostatic disease. Serum and urinary total hCGbeta was measured prior to treatment and serum PSA was measured at diagnosis. The patients were treated along conventional lines and progression-free survival was assessed. Four patients had elevated serum and 10 had elevated urinary, total hCGbeta. There were no significant correlations between serum/urinary levels of hCGbeta and tumour stage, Gleason score or PSA. In contrast, serum PSA had significant linear correlations with both clinical tumour stage and Gleason score (p = 0.0001). At a median follow-up of 36 months, 22 (21.2%) patients had died while 17 (16.3%) others had progressed. Kaplan-Meier plots and log-rank test revealed no significant difference in progression-free survival between patients with elevated or normal levels of serum and/or urinary total hCGbeta. Clinical tumour stage, grade and PSA were statistically significant prognostic variables. Immunoassay measurement of serum or urinary hCGbeta has no significant role in the clinical management of prostate cancer.
authors.affiliation: Williamson Laboratory, Barts and the London Queen Mary School of Medicine and Dentistry, St. Bartholomew's and the Royal London Hospitals, London, UK.
authors.forename: U
authors.initials: U
authors.lastname: Otite
authors.forename: S
authors.initials: S
authors.lastname: Baithun
authors.forename: F
authors.initials: F
authors.lastname: Chinegwundoh
authors.forename: V H
authors.initials: VH
authors.lastname: Nargund
authors.forename: R K
authors.initials: RK
authors.lastname: Iles
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood* / Q000652:urine*; D018450:Disease Progression; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000628:therapy / Q000652:urine*; D015203:Reproducibility of Results; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human