title: [Depression in children and adolescents].
abstract: Early onset depression is a widely prevalent, recurrent and familial disorder with a tendency to continue throughout adulthood. It is often accompanied by other comorbidities such as substance abuse, bipolar disorder, suicidal behavior and significant impairment in the child's psychosocial development. The risk factors include genetic, psychological and environmental factors and gene-environment interaction. The evidence-based therapies include cognitive, inter-personal and pharmacological interventions. Recently, the FDA published a warning concerning the use of these pharmacological agents in the pediatric age group. Further research is needed to assess the efficacy and safety of these interventions and to better understand the etiological factors.
authors.affiliation: Neuroscience Division, Columbia University, USA. zalsman@neuron.cpmc.columbia.edu
authors.forename: Gil
authors.initials: G
authors.lastname: Zalsman
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: David A
authors.initials: DA
authors.lastname: Brent
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use; D002648:Child; D002657:Child Development; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D000297:Psychology, Adolescent; D002666:Psychology, Child; D012307:Risk Factors; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000928:Antidepressive Agents