title: Does contrast medium administration in organ donors affect early kidney graft function?
abstract: Since the upper age for organ donors has been raised, a higher incidence of preexistent organ damage and functional impairment is to be expected. Coronary artery sclerosis increases with age. It can only be diagnosed with certainty by coronary angiography. Since contrast medium administration may cause renal damage when risk factors are present, this study sought to establish whether angiography negatively influenced the early postoperative function of kidney grafts. We compared the clinical courses of 36 recipients of kidneys from donors in whom coronary angiography or levography had been performed with 36 recipients of kidneys from donors who had not been subjected to contrast medium. The results showed that the administration of contrast medium had no influence on renal function at 3 or 6 months after transplantation. In conclusion, fears that donor kidneys might be harmed by contrast medium appeared to therefore be unfounded.
authors.affiliation: Deutsche Stiftung Organtransplantation, Northeast Region, Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Grosse
authors.forename: B
authors.initials: B
authors.lastname: Brauer
authors.forename: O
authors.initials: O
authors.lastname: Kücük
authors.forename: R
authors.initials: R
authors.lastname: Krüger
authors.forename: F
authors.initials: F
authors.lastname: Polster
authors.forename: O
authors.initials: O
authors.lastname: Grauhan
authors.forename: C
authors.initials: C
authors.lastname: Wesslau
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008875:Middle Aged; D018579:Patient Selection; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D003404:Creatinine