[Changes of hemodynamics during establishment of animal model of acute myocardial infarction induced by ligation of left coronary artery in goat].
OBJECTIVE
To study the changes in hemodynamics in experimental acute myocardial infarction induced by ligation of the left coronary artery in goat.


METHODS
Animal model of acute myocardial infarction was reproduced in 20 goats by ligation of the left coronary artery through xyphoid process. ST segment of electrocardiogram (ECG), mean artery blood pressure (MAP), central venous pressure (CVP), and heart rate (HR) were observed before, immediately, 30 minutes, 1 hour and 2 hours after ligation of the left coronary artery.


RESULTS
ECG of all goats was normal before operation. Immediately and 30 minutes after ligation, elevation of ST-segment was seen in 8 and 10 goats respectively, and in 18 goats elevation of ST-segment was observed 2 hours after ligation. Four weeks after the operation, pathological Q wave was shown in the chest leads of ECG in 18 goats. There was no significant difference in MAP, CVP and HR between before and after ligation. Frequent ventricular premature beats were found in 6 goats, but they were stopped after intravenous infusion of lidocaine.


CONCLUSIONS
Small area of experimental acute myocardial infarction in goats shows slight effect on hemodynamics, though the production of myocardial infarction is reliable, and the life of the goats could be maintained for a long time after the ligation of the left coronary artery. The experiment provides a valuable animal model for the study of coronary heart disease.
Wang
Xiao-bin
XB
Department of Anaesthesiology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, China. wangxiaobin67@sohu.com
Xie
Hui-qi
HQ
Liao
Bin
B
Wei
Ji-cheng
JC
Tang
Xian-ling
XL
D000818:Animals; D003331:Coronary Vessels / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D006041:Goats; D006439:Hemodynamics; D008026:Ligation / Q000379:methods; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D011897:Random Allocation