Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates.
High cytoplasmic expression of maspin was described in ovarian cancers of shorter survival rates. Until now, no relationship has been described between expression of maspin and sensitivity to cisplatin in ovarian cancers. This study aimed at examining the relationship between expression of maspin, detected by immunohistochemistry and clinical response to cisplatin in ovarian cancer cases as well as the in vitro sensitivity to cisplatin of 11 ovarian cancer cell lines. The analyzes were performed on 73 samples of ovarian cancer and on A2780P, A2780RCIS, CAOV-3, EFO 21, EFO 27, ES-2, Mdah 2774, OAW 42, OVCAR-3, PA-1, and SKOV-3 ovarian cancer cells. Cytoplasmic maspin expression in studied cells significantly correlated with cisplatin sensitivity. A significantly shorter overall survival and progression-free survival was associated with lower cytoplasmic maspin expression at first-look laparotomies and nuclear maspin expression and secondary cytoreductions. Higher nuclear maspin at first-look laparotomies expression was specific for cases of complete response. In the study, the elevated expression of maspin was shown to be typical for cisplatin-sensitive ovarian cancers.
Surowiak
Pawel
P
Institute of Pathology, Charité Campus Mitte, Berlin, Germany.
Materna
Verena
V
Drag-Zalesinska
Malgorzata
M
Wojnar
Andrzej
A
Kaplenko
Irina
I
Spaczyński
Marek
M
Dietel
Manfred
M
Zabel
Maciej
M
Lage
Hermann
H
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002467:Cell Nucleus / Q000378:metabolism; D002945:Cisplatin / Q000627:therapeutic use*; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D010053:Ovary / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015843:Serpins / Q000235:genetics / Q000378:metabolism*; D015996:Survival Rate
D000970:Antineoplastic Agents; C085344:SERPIN-B5; D015843:Serpins; D002945:Cisplatin