title: Abnormal selective attention normalizes P3 amplitudes in PDD.
abstract: This paper studied whether abnormal P3 amplitudes in PDD are a corollary of abnormalities in ERP components related to selective attention in visual and auditory tasks. Furthermore, this study sought to clarify possible age differences in such abnormalities. Children with PDD showed smaller P3 amplitudes than controls, but no abnormalities in selective attention. Adolescents with PDD showed abnormal selective attention, as reflected by larger auditory Processing Negativity (PN) and visual N2b, but no P3 abnormalities. Dipole localizations revealed that the locations of PN generators in subjects with PDD differed from controls. It was concluded that the abnormalities in selective attention in adolescents with PDD have a normalizing effect on P3, and possibly act as a compensatory process.
authors.affiliation: Department of Psychopharmacology, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584CA, Utrecht, The Netherlands. m.r.hoeksma@pharm.uu.nl
authors.forename: Marco R
authors.initials: MR
authors.lastname: Hoeksma
authors.forename: Chantal
authors.initials: C
authors.lastname: Kemner
authors.forename: J Leon
authors.initials: JL
authors.lastname: Kenemans
authors.forename: Herman
authors.initials: H
authors.lastname: van Engeland
mesh_terms: D000293:Adolescent; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology / Q000523:psychology; D001308:Auditory Perceptual Disorders / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology / Q000523:psychology*; D004569:Electroencephalography; D004585:Electrooculography; D005071:Evoked Potentials; D006801:Humans; D007360:Intelligence; D012016:Reference Values