Pluronic F127 gel effectively controls the burst release of drug from PLGA microspheres.
To investigate the controlled release effect of a thermo-sensitive gel, Pluronic F127 (PF127) on microspheres, poly[D,L-lactic-co-glycolic acid] (PLGA) microspheres were coated with Pluronic F127 gel and the in vitro release was evaluated. The results demonstrated that PF127, which gelled at 37 degrees C, inhibited the initial burst release of drug from microspheres effectively.
Wang
Y
Y
Colege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China.
Gao
J Q
JQ
Chen
H L
HL
Zheng
C H
CH
Liang
W Q
WQ
D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D008863:Microspheres; D020442:Poloxamer; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*
D005079:Excipients; D008567:Membranes, Artificial; D011108:Polymers; D020442:Poloxamer; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid