Oxidative stress in aldosteronism.
Congestive heart failure (CHF) is more than a failing heart and salt-avid state. Also present is a systemic illness which features oxidative stress in diverse tissues, a proinflammatory phenotype, and a wasting of soft tissue and bone. Reactive oxygen and nitrogen species contribute to this illness and the progressive nature of CHF. Aldosteronism, an integral component of the neurohormonal profile found in CHF, plays a permissive role in leading to an altered redox state. Because of augmented urinary and fecal excretion of Ca(2+) and Mg(2+) and consequent decline in plasma-ionized [Ca(2+)](o) and [Mg(2+)](o) that accompanies aldosteronism, parathyroid glands release parathyroid hormone (PTH) in an attempt to restore Ca(2+) and Mg(2+) homeostasis; this includes bone resorption. However, PTH-mediated intracellular Ca(2+) overloading, considered a Ca(2+) paradox, leads to oxidative stress. This can be prevented by: spironolactone, an aldosterone receptor antagonist that rescues urinary and fecal cation losses; parathyroidectomy; amlodipine, a Ca(2+) channel blocker; N-acetylcysteine, an antioxidant. In addition to the role played by aldosteronism in the appearance of secondary hyperparathyroidism is the chronic use of a loop diuretic, which further enhances urinary Ca(2+) and Mg(2+) excretion, and reduced Ca(2+) stores associated with hypovitaminosis D. This broader perspective of CHF and the ever increasing clinical relevance of divalent cations and oxidative stress raise the question of their potential management with macro- and micronutrients. An emerging body of evidence suggests the nutritional management of CHF offers an approach that will be complementary to today's pharmaceutical-based strategies.
Sun
Yao
Y
Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, 920 Madison Ave., Suite 300, Memphis, 38163, USA.
Ahokas
Robert A
RA
Bhattacharya
Syamal K
SK
Gerling
Ivan C
IC
Carbone
Laura D
LD
Weber
Karl T
KT
D000818:Animals; D002118:Calcium / Q000378:metabolism; D019587:Dietary Supplements; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008903:Minerals / Q000627:therapeutic use; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010281:Parathyroid Hormone / Q000378:metabolism; D014815:Vitamins / Q000627:therapeutic use
D008903:Minerals; C470125:PTH protein, human; D010281:Parathyroid Hormone; D014815:Vitamins; D008274:Magnesium; D002118:Calcium