title: Elevated serum surfactant protein A and D in pulmonary alveolar microlithiasis.
abstract: Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by widespread localization of calcispherites in the alveolar spaces. The authors report two cases of PAM, with markedly elevated sera concentrations of surfactant protein-A and surfactant protein-D, which showed a tendency to increase as the disease progressed. Therefore, surfactant protein-A and surfactant protein-D may function as serum markers to monitor the disease activity and progression of PAM.
authors.affiliation: The Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Chiba
authors.forename: Masanori
authors.initials: M
authors.lastname: Shiratori
authors.forename: Teruo
authors.initials: T
authors.lastname: Tachibana
authors.forename: Shosaku
authors.initials: S
authors.lastname: Abe
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D020347:Lithiasis / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D