title: Evaluation of super-high-dose steroid therapy for sudden sensorineural hearing loss.
abstract: OBJECTIVE
  To determine the efficacy of a high-dose steroid regimen for patients with sudden sensorineural hearing loss (SSNHL) and to evaluate the relationship between outcome and initial steroid dose.
  
  
  METHODS
  We conducted a retrospective study of 112 patients presenting to Saitama Medical Center. Patients received tapering courses of hydrocortisone (HC) with an initial dose of either 1200 mg or 600 mg.
  
  
  RESULTS
  More than 87% of patients had recovery of hearing. When hearing stabilized, there were no significant differences between the 1200 mg and 600 mg groups in terms of hearing outcome (P>0.05). However, at completion of treatment, the 1200 mg group exhibited significantly superior complete recovery rate and improvement rate (P<0.05).
  
  
  CONCLUSIONS
  Application of our treatment protocol of a tapered course of 1200 mg HC significantly and rapidly improves recovery outcomes in patients of SSNHL.
  
  
  METHODS
  C-4.
authors.affiliation: Department of Otorhinolaryngology, Saitama Medical Center, Saitama Medical School, Saitama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
authors.forename: Hideki
authors.initials: H
authors.lastname: Takegoshi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kikuchi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001299:Audiometry; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006309:Hearing / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000627:therapeutic use; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone