title: Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome.
abstract: Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.
authors.affiliation: Institute of Biology and Human Genetics, School of Medicine, 26 Visegradska Str., 11000 Belgrade, Serbia and Montenegro. biljanaj@verat.net
authors.forename: Biljana
authors.initials: B
authors.lastname: Jekic
authors.forename: Ivana
authors.initials: I
authors.lastname: Novakovic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Lukovic
authors.forename: Milos
authors.initials: M
authors.lastname: Kuzmanovic
authors.forename: Branka
authors.initials: B
authors.lastname: Popovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Milasin
authors.forename: Gordana
authors.initials: G
authors.lastname: Bunjevacki
authors.forename: Tatjana
authors.initials: T
authors.lastname: Damnjanovic
authors.forename: Suzana
authors.initials: S
authors.lastname: Cvjeticanin
authors.forename: Vera
authors.initials: V
authors.lastname: Bunjevacki
mesh_terms: D002675:Child, Preschool; D003062:Codon / Q000235:genetics; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D005091:Exons / Q000235:genetics; D016236:Genes, fms / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D003062:Codon; D004273:DNA, Neoplasm