title: Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.
abstract: Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.
authors.affiliation: Department of Clinical Pharmacy, Medical Center Rijnmond-Zuid, Olympiaweg 350, 3078 HT Rotterdam, The Netherlands. e.j.ruijgrok@hetnet.nl
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Ruijgrok
authors.forename: Marcel H A M
authors.initials: MH
authors.lastname: Fens
authors.forename: Irma A J M
authors.initials: IA
authors.lastname: Bakker-Woudenberg
authors.forename: Els W M
authors.initials: EW
authors.lastname: van Etten
authors.forename: Arnold G
authors.initials: AG
authors.lastname: Vulto
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D015415:Biomarkers / Q000378:metabolism; D007275:Injections, Intravenous; D008081:Liposomes; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology; D009330:Nebulizers and Vaporizers / Q000382:microbiology; D051381:Rats; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015415:Biomarkers; D008081:Liposomes; D000666:Amphotericin B