[Candiduria in intensive care unit: significance and value of yeast numeration in urine].
BACKGROUND
Candiduria is increasingly frequent among patients admitted to intensive care units but its significance remains unclear.


OBJECTIVE
Search for eventual correlation between quantitative candiduria and known risk factors for invasive candidiasis.


METHODS
Prospective.


METHODS
A four-month study was conducted in 162 patients hospitalized in the intensive care unit for more than 72 hours. All patients underwent a weekly research of candiduria added to sampling from different body sites to determine the Pittet Candida colonization index.


RESULTS
Candiduria has been proved in 56 cases (34%). It was superior or equal to 10(4) UFC/ml among 28 patients (50%). Candida tropicalis, Candida glabrata and Candida albicans has been isolated in 41, 22 and 20% respectively. All patients had at least one major and two minor risk factors for Candida infection. Six patients (10%) developed invasive candidiasis. The global mortality rate was at 52%. Pittet colonization index was significantly different between patients with candiduria and those with invasive candidiasis (p=0.01). There was a statistically significant correlation between candiduria superior or equal to 10(4) UFC/ml and Pittet colonization index superior or equal to 0.5 (p=0.01).


CONCLUSIONS
Candiduria superior or equal to 10(4) UFC/ml associated with risk factors may predict invasive candidiasis in critically ill patients.
Sellami
A
A
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Sfax, Tunisie.
Sellami
H
H
Makni
F
F
Bahloul
M
M
Cheikh-Rouhou
F
F
Bouaziz
M
M
Ayadi
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000302:isolation & purification*; D002176:Candida albicans / Q000302:isolation & purification; D041221:Candida glabrata / Q000302:isolation & purification; D041022:Candida tropicalis / Q000302:isolation & purification; D002177:Candidiasis / Q000652:urine*; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003422:Critical Care; D005260:Female; D016469:Fungemia / Q000382:microbiology; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000382:microbiology