title: Comparison of intracarotid anesthetics for EEG silence.
abstract: The goal of this study was to compare systemic and cerebrovascular effects of three anesthetic drugs (etomidate, thiopental, and propofol) when delivered by intracarotid and intravenous routes in doses that produce electrocerebral silence (electroencephalography [EEG]). EEG activity, mean arterial pressure (MAP), and laser Doppler flow as a proxy of cerebral blood flow (CBF) of 24 anesthetized New Zealand white rabbits were continuously recorded. Data were compared at three timepoints: baseline, during EEG silence, and after recovery of EEG activity. Drugs were randomly injected via the carotid artery to produce 10 minutes of EEG silence. After 30 minutes of rest, intravenous boluses of the same drug were injected to achieve 10 minutes of EEG silence. During EEG silence, transient hypotension was seen with intracarotid propofol, but there was no decrease in CBF. MAP and CBF did not decrease with either intracarotid etomidate or thiopental during EEG silence. Intracarotid/intravenous dose ratio of propofol (26%+/-22%; n=8, P<0.02) was much higher than that of etomidate and thiopental (14%+/-2% and 19%+/-11%, respectively; NS). Collectively, these results suggest intracarotid etomidate and thiopental are more useful than propofol in producing EEG silence because they offer better dose advantage and are less likely to impair cerebral or systemic hemodynamics.
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, P&S Box 46, New York, NY 10032, USA. sj121@columbia.edu
authors.forename: Shailendra
authors.initials: S
authors.lastname: Joshi
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Joshua
authors.initials: J
authors.lastname: Etu
authors.forename: Ervant V
authors.initials: EV
authors.lastname: Nishanian
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004569:Electroencephalography / Q000187:drug effects*; D005045:Etomidate / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D015742:Propofol / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013874:Thiopental / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol; D005045:Etomidate