title: [The male's role in the etiology of preeclampsia].
abstract: Preeclampsia is a major cause of morbidity and mortality in mothers, fetuses, and neonates worldwide, with 5%-10% of human births being affected. The cause is still uncertain, and many controversies exist concerning its management. Preeclampsia-eclampsia is due to the failure of extra-villous cytotrophoblast to invade the maternal uterine spiral arteries to a sufficient depth, inducing poor vascular exchanges between the mother and the placenta. This physiological endovascular trophoblast invasion represents a remarkable immunological placental-maternal interaction. Recent data strongly indicate an important role for the male partner in the causation of this common pregnancy disorder. This review aims to discuss the relevant literature and to explain how paternal, relational and sexual factors play an important role in the etiology of preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. gutguy10@yahoo.com
authors.forename: Guy
authors.initials: G
authors.lastname: Gutman
authors.forename: Ohad
authors.initials: O
authors.lastname: Hilly
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Lessing
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kupferminc
authors.forename: David
authors.initials: D
authors.lastname: Pauzner
mesh_terms: D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D010332:Paternal Behavior; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy