title: Role of ventricular Autocapture function in increasing longevity of DDDR pacemakers: a prospective study.
abstract: OBJECTIVE
  Autocapture is an algorithm for automatic adaptation of ventricular output to capture threshold. The aim of this prospective study was to estimate the effects of ventricular Autocapture algorithm on DDD-DDDR pacemaker longevity.
  
  
  RESULTS
  Eighty-three patients implanted with a DDD-DDDR pacemaker (Affinity or Entity; St Jude Medical, USA) were enrolled and the Autocapture function was activated pre-discharge. Ventricular pulse duration was randomly programmed at 0.3 or 0.4 ms, with a cross-over at 8-12 weeks and again at 13-14 months. Diagnostic data were retrieved from device memory and by calculating battery current drain from long-term threshold recordings; device longevity was estimated at the following settings: Autocapture with a pulse duration of 0.3 and 0.4 ms, respectively, standard output (3.5 V, 0.4 ms) and conventional low output programming (2.5 V, 0.4 ms). According to a series of assumptions, Autocapture was associated with a 55-60% increase in estimated device longevity compared with standard output programming and a 6-7% increase in longevity compared with low output programming. No significant differences were found between Autocapture programmed with a pulse duration of 0.3 or 0.4 ms. In projections to a 10-year follow-up, use of the Autocapture function resulted in a 42% reduction in pacing-related estimated costs compared with standard output programming at 3.5 V, 0.4 ms.
  
  
  CONCLUSIONS
  Pacing with constant adaptation of ventricular output in dual-chamber devices has the potential to increase generator longevity and to reduce sizeably pacing-related costs compared with standard programming.
authors.affiliation: Institute of Cardiology, University of Bologna, Azienda Ospedaliera Policlinico S.Orsola-Malpighi, Via Massarenti, 9 40138 Bologna, Italy. cardio1@almadns.unibo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Boriani
authors.forename: Luigi
authors.initials: L
authors.lastname: Rusconi
authors.forename: Mauro
authors.initials: M
authors.lastname: Biffi
authors.forename: Letterio
authors.initials: L
authors.lastname: Pavia
authors.forename: Massimo
authors.initials: M
authors.lastname: Sassara
authors.forename: Dario
authors.initials: D
authors.lastname: Malfitano
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bongiorni
authors.forename: Luigi
authors.initials: L
authors.lastname: Padeletti
authors.forename: Ignazio
authors.initials: I
authors.lastname: Filice
authors.forename: Daniela
authors.initials: D
authors.lastname: Sanfelici
authors.forename: Pietro
authors.initials: P
authors.lastname: Maffei
authors.forename: Alfredo
authors.initials: A
authors.lastname: Vicentini
authors.forename: Angelo
authors.initials: A
authors.lastname: Branzi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial; D018592:Cross-Over Studies; D011211:Electric Power Supplies; D004868:Equipment Failure; D005260:Female; D006327:Heart Block / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011446:Prospective Studies; D016276:Ventricular Function