title: Growth inhibition by metabolites of gamma-hexachlorocyclohexane in Sphingobium japonicum UT26.
abstract: The growth of a gamma-hexachlorocyclohexane (gamma-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by gamma-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for gamma-HCH degradation, suggesting that metabolites of gamma-HCH are toxic to UT26. Two metabolites of gamma-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during gamma-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.
authors.affiliation: Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Endo
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohtsubo
authors.forename: Masataka
authors.initials: M
authors.lastname: Tsuda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D015394:Molecular Structure; D042301:Sphingomonadaceae / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D001556:Hexachlorocyclohexane