End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation.
We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.
Apetauerova
Diana
D
Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts, USA.
Ryan
R Kevin
RK
Ro
Susie I
SI
Arle
Jeffrey
J
Shils
Jay
J
Papavassiliou
Efstathios
E
Tarsy
Daniel
D
D046690:Deep Brain Stimulation; D020820:Dyskinesias / Q000209:etiology* / Q000628:therapy*; D005260:Female; D007839:Functional Laterality; D005917:Globus Pallidus; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D020531:Subthalamic Nucleus