title: Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors.
abstract: Using a dipeptide nitrile scaffold we have identified a potent and selective inhibitor of human dipeptidyl peptidase I.
authors.affiliation: Arpida A/S, Vesterbrogade 188, DK-1800 Frederiksberg C, Denmark. jbondebjerg@arpida.uk
authors.forename: Jon
authors.initials: J
authors.lastname: Bondebjerg
authors.forename: Henrik
authors.initials: H
authors.lastname: Fuglsang
authors.forename: Kirsten Rosendal
authors.initials: KR
authors.lastname: Valeur
authors.forename: John
authors.initials: J
authors.lastname: Pedersen
authors.forename: Lars
authors.initials: L
authors.lastname: Naerum
mesh_terms: D020789:Cathepsin C / Q000037:antagonists & inhibitors*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004151:Dipeptides; D004791:Enzyme Inhibitors; D009570:Nitriles; D020789:Cathepsin C