Dynamin as a mover and pincher during cell migration and invasion.
The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.
Kruchten
Anne E
AE
Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
McNiven
Mark A
MA
D000199:Actins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008055:Lipids / Q000737:chemistry; D011485:Protein Binding; D011554:Pseudopodia / Q000378:metabolism / Q000648:ultrastructure
D000199:Actins; D008055:Lipids; D034281:Dynamins