title: Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense.
abstract: A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC(50) values ranging from 0.65 to 5.2 microg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC(50) values of 3.2, 4.9, 7.2 and 2.6 microg/ml, respectively.
authors.affiliation: School of Science, Mae Fah Luang University, Thasud, Muang, Chiang Rai 57100, Thailand. surat@mfu.ac.th
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
authors.forename: John Keith
authors.initials: JK
authors.lastname: Syers
authors.forename: Rattana
authors.initials: R
authors.lastname: Kiattansakul
authors.forename: Kan
authors.initials: K
authors.lastname: Chantrapromma
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D028084:Clusiaceae / Q000737:chemistry*; D003124:Colorimetry; D006801:Humans; D007624:KB Cells; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones