Three cousins with chronic foot ulcers from late-onset hereditary sensory and autonomic neuropathies type 2 (HSAN2).
The hereditary sensory and autonomic neuropathies (HSAN) are a group of rare disorders characterized by prominent sensory and autonomic neuropathy without motor involvement. We report three male cousins with chronic foot ulcers, all were affected with late-onset HSAN type 2 (HSAN2). In view of the history of consanguinity and male sex, X-linked recessive transmission was likely in our patients. According to the authors' knowledge this is the first report of HSAN2 from Iran.
Aghaei
Shahin
S
Department of Dermatology, Jahrom Medical School, Jahrom, Iran. shahinaghaei@yahoo.com
Pakmanesh
Kambiz
K
D000293:Adolescent; D016523:Foot Ulcer / Q000209:etiology* / Q000473:pathology; D040181:Genetic Diseases, X-Linked / Q000150:complications; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000150:complications / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male