title: Sesquiterpene lactones from Crepis cameroonica (Asteraceae).
abstract: In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.
authors.affiliation: Faculty of Science, Department of Organic Chemistry, Faculty of Science, University of Douala, Douala, P.O. Box 24157, Cameroon. ndomjefr@yahoo.fr
authors.forename: J C
authors.initials: JC
authors.lastname: Ndom
authors.forename: J T
authors.initials: JT
authors.lastname: Mbafor
authors.forename: J D
authors.initials: JD
authors.lastname: Wansi
authors.forename: A W
authors.initials: AW
authors.lastname: Kamdem
authors.forename: L M
authors.initials: LM
authors.lastname: Meva'a
authors.forename: J C
authors.initials: JC
authors.lastname: Vardamides
authors.forename: F
authors.initials: F
authors.lastname: Toukam
authors.forename: D
authors.initials: D
authors.lastname: Pegyemb
authors.forename: T M
authors.initials: TM
authors.lastname: Ngando
authors.forename: H
authors.initials: H
authors.lastname: Laatsch
authors.forename: Z T
authors.initials: ZT
authors.lastname: Fomum
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027468:Crepis; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes