Serum molybdenum concentration in healthy Japanese adults determined by inductively coupled plasma-mass spectrometry.
The serum molybdenum (Mo) concentrations in 70 Japanese adults (35 males and 35 females) not receiving any medical care or treatment were determined by inductively coupled plasma-mass spectrometry. Serum Mo concentration in the subjects ranged from <0.1 to 9.11 ng/mL. More than half (55.7%) of the subjects showed values of less than 1 ng/mL and only 6 (8.6%) subjects showed more than 2 ng/mL. The mean+/-SD, geometrical mean (GM), range of GM+/-geometrical SD (GSD) and median value were 1.21+/-1.34, 0.81, 0.30 to 2.16, and 0.90 ng/mL, respectively. Among age, body mass index and several serum biochemical values, activities of aspartate aminotransferase and alanine aminotransferase showed significant associations with serum Mo; 15 subjects suspected of having liver dysfunction showed significantly higher serum Mo than others. We propose a range of 0.10-4.73 ng/mL, estimated as a range of GM+/-2GSD of serum Mo in the remaining 55 subjects without liver dysfunction, as a reference range of serum Mo in Japanese healthy adults.
Yoshida
Munehiro
M
Laboratory of Food and Nutritional Sciences, Faculty of Engineering, Kansai University, Yamate 3-3-35 Suita, Osaka 564-8680, Japan. hanmyou4@ipcku.kansai-u.ac.jp
Ota
Sachie
S
Fukunaga
Kenji
K
Nishiyama
Toshimasa
T
D000328:Adult; D017677:Age Distribution; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D008982:Molybdenum / Q000097:blood*; D012016:Reference Values; D012680:Sensitivity and Specificity
D008982:Molybdenum; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase