title: Dietary deficiencies of single amino acids: whole-body amino acid composition of adult rats.
abstract: To ascertain whether chronic amino acid deficiency alters the amino acid composition of the body, 44 adult female rats were randomly allocated to one of 11 treatments which included one control group, ingesting an adequate diet with balanced protein, and ten deficient groups in which one group received protein-deficient diets and the other groups consumed diets each deficient in a single essential amino acid. The degree of deficiency was adjusted to achieve a gradual decline in body weight to 85% of the initial weight and was then adjusted so that this weight was maintained until the end of the experiment at 93 days, when the rats were killed. Deficient rats had lower absolute weights of liver, gastrointestinal tract and muscle than animals given the adequate diet but greater relative weights (% of body weight) of heart and kidneys. There were no significant differences amongst groups in percentages of lipid, nitrogen, protein plus lipid or dry matter. Chronic marginal amino acid deficiencies did not selectively alter amino acid composition.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK.
authors.forename: Hen-Wei
authors.initials: HW
authors.lastname: Wei
authors.forename: Malcolm
authors.initials: M
authors.lastname: Fuller
mesh_terms: D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000172:deficiency* / Q000378:metabolism*; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D009929:Organ Size / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats
chemical_list: D000601:Amino Acids, Essential; D004044:Dietary Proteins