Peripheral T-cell lymphoma-unspecified (PTCL-U) presenting with hypereosinophilic syndrome and pleural effusions.
Hypereosinophilic syndrome (HES) is a clinical disorder characterized by persistent eosinophilia and systemic involvement, in which a specific causative factor for the eosinophilia cannot be verified during a certain period of time. There have been only a few reported cases of this syndrome associated with malignant lymphoma. We report a case of peripheral T-cell lymphoma-unspecified with hypereosinophilic syndrome. The patient was a 42-year-old woman with an uncontrolled fever and a sore throat. Eosinophilia was observed on the peripheral blood smear. We confirmed the diagnosis by bone marrow and liver biopsies:. A bone marrow aspiration demonstrated markedly increased eosinophils (24.8%), and a liver biopsy demonstrated infiltration by scattered eosinophils and atypical lymphoid cells, which were confirmed to be T-cell lymphoma cells. This case was a distinctive presentation of peripheral T-cell lymphoma with hypereosinophilic syndrome, probably due to a paraneoplastic condition.
Choi
Won
W
Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Park
Yeon Hee
YH
Paik
Kwang Hyun
KH
Chang
Yoon Hwan
YH
Lee
Seung-Sook
SS
Ryoo
Baek-Yeol
BY
Yang
Sung Hyun
SH
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000175:diagnosis*; D010996:Pleural Effusion / Q000209:etiology*; D012008:Recurrence