Plasma level of IL-6 and its relationship to procoagulant and fibrinolytic markers in acute ischemic stroke.
Procoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT), and plasminogen-antiplasmin complex (PAP). Circulating IL-6 levels were measured using ELISA (Quantikine, R and D systems, MN, USA). Circulating IL-6 (mean, 26.5 pg/mL) and PAI-1 (mean, 19.9 ng/mL) levels were higher in patients with acute stroke than in healthy subjects (mean, 3.0 pg/mL, 10.4 ng/mL, respectively). TAT levels were statistically different according to the etiologic subtypes of stroke (atherogenic, 2.5 ng/mL; lacunar 3.2 ng/mL; cardiogenic 9.9 ng/mL, p = 0.021). Neither procoagulant levels nor fibrinolytic markers significantly correlated with circulating IL-6 levels. Our findings suggest that elevated proinflammatory cytokines during the initial hours of ischemic stroke may be an independent pathogenic factor or a consequence of the thrombotic event with no relationship to the procoagulant or fibrinolytic states.
Song
Jae Woo
JW
Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.
Song
Kyung Soon
KS
Choi
Jong Rak
JR
Kim
Shin Young
SY
Rhee
Ji-Hyuk
JH
D000208:Acute Disease; D000368:Aged; D000991:Antithrombins / Q000737:chemistry; D001779:Blood Coagulation Factors / Q000378:metabolism; D003029:Coagulants / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000378:metabolism; D007511:Ischemia / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010743:Phospholipids / Q000737:chemistry; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D020521:Stroke / Q000097:blood* / Q000473:pathology*; D013917:Thrombin / Q000737:chemistry; D015912:Thrombolytic Therapy; D013927:Thrombosis
D000991:Antithrombins; D001779:Blood Coagulation Factors; D003029:Coagulants; D016207:Cytokines; D015850:Interleukin-6; D010743:Phospholipids; D017395:Plasminogen Activator Inhibitor 1; D013917:Thrombin