title: [Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke].
abstract: BACKGROUND
  Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations, being considered unfavourable genetic factors by causing elevated serum homocysteine levels, may be risk factors for cardiovascular disorders, including ischaemic stroke. In this study, the role of these two mutations in ischaemic stroke was examined:
  
  
  METHODS
  Genetic and clinical data were analysed of 122 ischaemic stroke patients and 102 control subjects with no lesions by neuroimaging.
  
  
  RESULTS
  Neither of the two MTHFR mutations alone was found to be a significant genetic risk factor for ischaemic stroke. However, at least one MTHFR 677T allele combined with at least one MTHFR 1298C allele significantly increased the risk of ischaemic stroke (adjusted odds ratio: 3.39; p < 0.001).
  
  
  CONCLUSIONS
  The synergistic effect between the two MTHFR mutations may represent a new genetic stoke risk factor.
authors.affiliation: Pándy Kálmán Megyei Kórház, I. Számú Neurológiai Osztály, Gyula. szolnoki99@hotmail.com
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szolnoki
authors.forename: Ferenc
authors.initials: F
authors.lastname: Somogyvári
authors.forename: Mihály
authors.initials: M
authors.lastname: Szabó
authors.forename: András
authors.initials: A
authors.lastname: Kondacs
authors.forename: Lajos
authors.initials: L
authors.lastname: Fodor
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000328:Adult; D000368:Aged; D000409:Alanine; D000483:Alleles; D002545:Brain Ischemia / Q000150:complications*; D003545:Cysteine; D005260:Female; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D018570:Risk Assessment; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D020521:Stroke / Q000209:etiology / Q000235:genetics*; D013912:Threonine
chemical_list: D013912:Threonine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D003545:Cysteine; D000409:Alanine