title: Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation.
abstract: Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and proinflammatory gene expression. When topically applied to ICR mouse ear, ginkgetin (20-80 microg/ear/treatment) inhibited ear edema (22.8-30.5%) and prostaglandin E2 production (30.2-31.1%) induced by multiple treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 7 consecutive days. By histological comparison, ginkgetin was also found to reduce epidermal hyperplasia. The expression of proinflammatory gene, interleukin-1beta, was suppressed by ginkgetin. From the results, it is suggested that ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.
authors.affiliation: College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Lim
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D044946:Biflavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003872:Dermatitis / Q000188:drug therapy*; D015232:Dinoprostone / Q000096:biosynthesis / Q000235:genetics; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044946:Biflavonoids; D005419:Flavonoids; C077458:ginkgetin; D015232:Dinoprostone