Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice.
In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.
Hori
Seiji
S
Department of Pharmacology (I), Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. horis@jikei.ac.jp
Kizu
Junko
J
Kawamura
Masahiro
M
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D015365:Enoxacin / Q000494:pharmacology; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D051379:Mice; D015363:Quinolones / Q000494:pharmacology
D001786:Blood Glucose; D024841:Fluoroquinolones; D015363:Quinolones; D015365:Enoxacin; D000077734:Gatifloxacin; C053091:lomefloxacin