title: Reverse engineering galactose regulation in yeast through model selection.
abstract: We examine the application of statistical model selection methods to reverse-engineering the control of galactose utilization in yeast from DNA microarray experiment data. In these experiments, relationships among gene expression values are revealed through modifications of galactose sugar level and genetic perturbations through knockouts. For each gene variable, we select predictors using a variety of methods, taking into account the variance in each measurement. These methods include maximization of log-likelihood with Cp, AIC, and BIC penalties, bootstrap and cross-validation error estimation, and coefficient shrinkage via the Lasso.
authors.affiliation: Institute for Systems Biology. thors-son@systemsbiology.org
authors.forename: Vesteinn
authors.initials: V
authors.lastname: Thorsson
authors.forename: Michael
authors.initials: M
authors.lastname: Hörnquist
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Siegel
authors.forename: Leroy
authors.initials: L
authors.lastname: Hood