Solubilization of valsartan by aqueous glycerol, polyethylene glycol and micellar solutions.
To increase the solubility of valsartan in aqueous solutions was considered of interest. This study therefore investigated the solubilization of valsartan by cosolvency and micellization. Of the solubilization agents used, sodium lauryl sulfate was found to be the most effective. The increase in solubility at the maximum concentration studied was in the following order: sodium lauryl sulfate > polysorbate-80 > polyethylene glycol 400 > glycerol. The effect of propylene glycol on the solubility of valsartan in a 2% w/v polysorbate-80 solution was also investigated and was found that propylene glycol decreased the solubilizing power of polysorbate-80 at the concentrations studied.
Mbah
C J
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DMI Inc., 86 N. Main Street, Wharton, NJ 07885, USA.
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D008823:Micelles; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D011136:Polysorbates; D012015:Reference Standards; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D012996:Solutions; D012997:Solvents; D013501:Surface-Active Agents; D013777:Tetrazoles / Q000008:administration & dosage / Q000737:chemistry*; D013816:Thermodynamics; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D000068756:Valsartan
D000959:Antihypertensive Agents; D008823:Micelles; D014677:Pharmaceutical Vehicles; D011136:Polysorbates; D012996:Solutions; D012997:Solvents; D013501:Surface-Active Agents; D013777:Tetrazoles; D012967:Sodium Dodecyl Sulfate; D011092:Polyethylene Glycols; D000068756:Valsartan; D014633:Valine; D005990:Glycerol