Adrenaline contributes to prenatal respiratory maturation in rat medulla-spinal cord preparation.
Adrenaline is a potent respiratory regulator. However, adrenergic contribution to the developing respiratory center has not been studied extensively. Adrenaline application on embryonic day 17 medulla-spinal cord block preparations abolished non-respiratory activity and enhanced respiratory frequency. Phentolamine application on neonatal blocks that produced stable neonatal respiration resulted in respiratory destabilization. These results suggest that central adrenergic modulation is involved in fetal respiratory development and maintenance of stable respiration.
Fujii
Morimitsu
M
Laboratory for Memory and Learning, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Umezawa
Kazuo
K
Arata
Akiko
A
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D004525:Efferent Pathways / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism* / Q000494:pharmacology; D008526:Medulla Oblongata / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D009415:Nerve Net / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009924:Organ Culture Techniques; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012125:Respiratory Center / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D013116:Spinal Cord / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D004837:Epinephrine; D010646:Phentolamine