title: Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues.
abstract: Seven known abietane diterpenoids and 11-O- and 12-O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yudai
authors.initials: Y
authors.lastname: Satake
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Aiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Shusuke
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Teruo
authors.initials: T
authors.lastname: Kurihara
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019686:Lamiaceae / Q000737:chemistry*; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D045784:Abietanes