title: The oxidative mannich reaction catalyzed by dirhodium caprolactamate.
abstract: Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C-H oxidation of a tertiary amine followed by nucleophilic capture. This green transformation is conducted in protic solvent using inexpensive T-HYDRO (70% t-BuOOH in water). Synthetically valuable gamma-aminoalkyl butenolides are obtained.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Catino
authors.forename: Jason M
authors.initials: JM
authors.lastname: Nichols
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Nettles
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
mesh_terms: D002384:Catalysis; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D012238:Rhodium