Androgen physiology.
Androgen receptors are present in numerous tissues throughout the female body, and knowledge of the specific actions of androgens at different sites is increasing, along with the understanding of their contribution to various pathophysiological states. This article reviews the physiology of androgens (testosterone and dihydrotestosterone) and immediate androgen precursors (dehydroepiandrosterone [DHEA], dehydroepiandrosterone sulfate [DHEAS], and androstenedione), with specific reference to the androgen receptor, production and metabolism of C- (19) steroids, circulating androgen concentrations, and androgen actions. In addition, the evidence for physiological modulation of androgens including circadian variation, cyclical variation, age, and natural menopause is reviewed.
Davison
Sonia Louise
SL
Women's Health Program, Department of Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria, Australia. Sonia.Davison@med.monash.edu.au
Bell
Robin
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000728:Androgens / Q000096:biosynthesis / Q000502:physiology*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008593:Menopause; D008597:Menstrual Cycle; D008875:Middle Aged; D009928:Organ Specificity; D017698:Postmenopause; D011944:Receptors, Androgen / Q000032:analysis / Q000235:genetics / Q000378:metabolism
D000728:Androgens; D011944:Receptors, Androgen