The safety of trivalent influenza vaccine among healthy children 6 to 24 months of age.
OBJECTIVE
The objective of this study was to assess the safety of routine trivalent influenza vaccine (TIV) administration among healthy children 6 through 23 months of age, after the Advisory Committee on Immunization Practices recommendation.


METHODS
The study was a retrospective case-control study of children receiving TIV in the first 2 seasons after the Advisory Committee on Immunization Practices recommendation. We assessed outcomes in the 42 days after vaccination in a population of 13,383 children. Each case subject was matched, according to age and gender, with 3 control subjects. Hazard ratios were calculated with conditional logistic regression analysis.


RESULTS
We found no statistically significantly elevated hazard ratios for the first TIV dose. An elevated risk of pharyngitis was found for children receiving a second TIV dose. No elevated risk of seizure was found.


CONCLUSIONS
These results, for a population of healthy children, showed no medically significant adverse events related to TIV among children 6 to 23 months of age.
Goodman
Michael J
MJ
HealthPartners Research Foundation, Minneapolis, Minnesota 55440-1524, USA. michael.j.goodman@healthpartners.com
Nordin
James D
JD
Harper
Peter
P
Defor
Teri
T
Zhou
XingZhou
X
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007252:Influenza Vaccines / Q000009:adverse effects*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male
D007252:Influenza Vaccines