title: Small organic molecules that modulate gene transcription.
abstract: Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory. Small-molecule modulators of transcription, including small-molecule transcription factors could find their use in basic biological studies and therapeutic intervention.
authors.affiliation: The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Dongju
authors.initials: D
authors.lastname: Jung
authors.forename: Yongmun
authors.initials: Y
authors.lastname: Choi
authors.forename: Motonari
authors.initials: M
authors.lastname: Uesugi
mesh_terms: D000218:Adamantane / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011487:Protein Conformation; D014157:Transcription Factors / Q000138:chemical synthesis*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D014157:Transcription Factors; C474394:adamanolol; C486112:wrenchnolol; D000218:Adamantane