title: Relationship between coronary heart disease and chronic renal insufficiency.
abstract: Coronary heart disease (CHD) is a worldwide public health problem. CHD is 100 times more prevalent than CHD with Chronic renal insufficiency (CRI), and its incidence is increasing at an even faster rate. The aim of this work is to determine the connection between CHD and risk factors in CHD patients with CRI. There were 78 patients (age 54,46+/-12,46 years), 45 males and 33 female. In group I were included 33 patients with CHD (57,7+/-9,03 years, in group II - 25 patients with CHD and CRI (59,35+/-10,64 years). The control group III - was composed of practically healthy persons 20 (40,7+/-12,6 years). Lipid spectrum was studied in blood serum using "Janway 4500" spectrometry, by the enzyme method using "BIOLABO" test (France). The received data was treated statistically M+/-SD(M-mean SD-standard deviation (SD). Student-t test was used for the analysis of the data obtained for the groups, statistical appearance was determined as p<0,05. Correlation was tested according to the Person's correlation. Data of our studies showed, that in group II level of lipid spectrum is lower than in group II. We suggested that these complex changes in lipid profiles may significantly contribute to the heavy pass CHD. Increased level of IA results from complex changes in lipid profiles. In group II the blood pressure (BP) is significantly (p<0,05) higher (172/94 mm/hg) than in group I (162/88 mm/hg). By literature a primary kidney defect can produce hypertension or increase a level of BP. According to our observation, dyslipidemia is significantly expressed in CHD patients with CRI, than without CRI. Data of our studies showed, that abnormal lipid spectrum is positively correlated with renal damage. Therefore, we can conclude CHD with CRI passes heavier than CHD without CRI.
authors.affiliation: National Centre of Therapy, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Sologhashvili
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*