title: Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).
abstract: Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.
authors.forename: Sung-Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Oh
authors.forename: Su-Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Dae Gwin
authors.initials: DG
authors.lastname: Jeong
authors.forename: Seong Eon
authors.initials: SE
authors.lastname: Ryu
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Dong Cho
authors.initials: DC
authors.lastname: Han
authors.forename: Nack-Do
authors.initials: ND
authors.lastname: Sung
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020946:Taxus / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D001688:Biological Products; D005419:Flavonoids; D009363:Neoplasm Proteins; C077458:ginkgetin; C086243:sciadopitysin; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases