title: [Study of differential gene expression in different stage human endometrial cancer].
abstract: OBJECTIVE
  To study the gene expression profile of different stage endometrial cancer and identify genes related to the progression and metastasis of endometrial cancer.
  
  
  METHODS
  cDNA microarray was used to analyze the differentially expressed genes between different stage endometrial cancers. The hierarchical cluster analysis was applied to the gene expression profile of 32 endometrial cancers.
  
  
  RESULTS
  Twelve differentially expressed genes were identified between different stage endometrial cancers. The conformity rate was 66% between the result of hierarchical cluster analysis and the operative-histological stages of International Federation of Gynecology and Obstetrics (FIGO).
  
  
  CONCLUSIONS
  Genes related to the endometrial cancer progression and metastasis can be identified by differential gene expression profile with cDNA microarray and high-risk endometrial cancer may be distinguished before surgery by hierarchical cluster analysis.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Wan
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Xi
authors.forename: Yi-xia
authors.initials: YX
authors.lastname: Yang
mesh_terms: D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016000:Cluster Analysis; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D012680:Sensitivity and Specificity