title: Identification of a novel 120 bp allele at the TNFd microsatellite locus.
abstract: Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in the TNF region, named TNF a-e. TNFb, TNFc, TNFd, and TNFe are (GA)n repeats, whereas TNFa and TNFf are (GT)n and (CA)n repeats, respectively. The TNFd microsatellite locus maps 8-10 kb centromeric to the TNF-alpha gene, downstream to the TNF-beta gene.
authors.affiliation: Program of Basic and Applied Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, Sp, Brazil.
authors.forename: I J
authors.initials: IJ
authors.lastname: Wastowski
authors.forename: N T A
authors.initials: NT
authors.lastname: Peres
authors.forename: R T
authors.initials: RT
authors.lastname: Simões
authors.forename: E C
authors.initials: EC
authors.lastname: Castelli
authors.forename: A L
authors.initials: AL
authors.lastname: Simões
authors.forename: N M
authors.initials: NM
authors.lastname: Martinez-Rossi
authors.forename: E A
authors.initials: EA
authors.lastname: Donadi
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000145:classification / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha