title: Synthesis and evaluation of cytotoxic activity of arylfurans.
abstract: A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.
authors.affiliation: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.
authors.forename: Renata B
authors.initials: RB
authors.lastname: de Oliveira
authors.forename: Elaine M
authors.initials: EM
authors.lastname: de Souza-Fagundes
authors.forename: Helen A J
authors.initials: HA
authors.lastname: Siqueira
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Leite
authors.forename: Claudio L
authors.initials: CL
authors.lastname: Donnici
authors.forename: Carlos L
authors.initials: CL
authors.lastname: Zani
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D005663:Furans