Nucleophilic perfluoroalkylation of aldehydes, ketones, imines, disulfides, and diselenides.
Using a procedure analogous to that developed for nucleophilic trifluoromethylation, the perfluoroalkyl anion reagents created by mixing C2F5I and n-C4F9I with tetrakis(dimethylamino)ethylene (TDAE) were effective in their nucleophilic reactions with aldehydes, ketones, imines, disulfides, and diselenides. Irradiation proved beneficial in the aldehyde and ketone reactions.
Pooput
Chaya
C
Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
Dolbier
William R
WR
Médebielle
Maurice
M