title: Simultaneous very low dose mifepristone and vaginal misoprostol for medical abortion.
abstract: OBJECTIVE
  This pilot study was designed to evaluate the outcome of medical abortion following simultaneous mifepristone (100 mg) and misoprostol (800 microg).
  
  
  METHODS
  Enrollees had gestational ages up to 56 days and desired a medical abortion. They received 100 mg of mifepristone orally and 800 microg of misoprostol vaginally. Follow-up examination occurred in 2-7 days. A phone call 3 weeks later assessed symptoms and acceptability. A 95% success rate, as seen in higher dose studies, gives a 95% confidence interval of 88-100% for 40 subjects.
  
  
  RESULTS
  Forty women were enrolled; 39 women had follow-up visits. Completed medical abortion was confirmed for 35 (90%) of 39 women. Four women had uterine aspiration. Two patients required repeat misoprostol. Median time from medication to abortion was 7 h. Most women (92%) strongly preferred taking all medications in the clinic.
  
  
  CONCLUSIONS
  The simultaneous administration of vaginal misoprostol with 100 mg of oral mifepristone had the outcome of completed abortion within the predicted confidence interval. In addition, simultaneous dosing was highly acceptable.
authors.affiliation: Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA. nkapp@bu.edu
authors.forename: Nathalie
authors.initials: N
authors.lastname: Kapp
authors.forename: Lynn
authors.initials: L
authors.lastname: Borgatta
authors.forename: Sacheen Carr
authors.initials: SC
authors.lastname: Ellis
authors.forename: Phillip
authors.initials: P
authors.lastname: Stubblefield
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D010865:Pilot Projects; D011247:Pregnancy
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone