No evidence of association between NOD2/CARD15 gene polymorphism and atherosclerotic events after renal transplantation.
Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated levels of C-reactive protein and by a correlation between posttransplant AE and Toll-like receptor-4 Asp299Gly polymorphism. Here, we analyze the influence NOD2/CARD15 gene polymorphism since NOD2 can modulate macrophage pro-inflammatory activity and macrophage is present in early atherosclerotic lesions. The incidence of single nucleotide polymorphism (SNP) in the three major polymorphic region of NOD2 gene (SNP8, SNP12 and SNP13) was assessed in 182 RTR and the correlation between such polymorphism and the development of AE was analyzed. No correlation was observed between NOD2 gene polymorphism and the occurrence of AE after renal transplantation. NOD2 gene polymorphism thus does not appear to influence cardiovascular complications in RTR.
Courivaud
Cécile
C
INSERM, U645, Besançon, France.
Ferrand
Christophe
C
Deschamps
Marina
M
Tiberghien
Pierre
P
Chalopin
Jean-Marc
JM
Duperrier
Anne
A
Saas
Philippe
P
Ducloux
Didier
D
D000328:Adult; D050197:Atherosclerosis / Q000209:etiology*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4