Management of anemic effects of chloramphenicol using amino acids on albino rats infected with Salmonella typhi.
Chloramphenicol is an antibiotic originally extracted from the fungus Streptomyces venezuelae, but it is now synthesized. It is a drug of choice for many of its toxicity in the blood-forming organs. The main objective of this study is to find out how to reduce the anemic effects of chloramphenicol and to increase its therapeutic efficacy using amino acid. In albino-rats infected with Salmonella typhi the results indicate that the rats became anemic after treatment with chloramphenicol. They also show that the combined treatment of chloramphenicol with amino acid yielded positive results in the management of anemia caused by chloramphenicol.
Chilaka
K C
KC
Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikwe University, Nnewi Campus, Anambra State, Nigeria. kins-cc@yahoo.com
Unekwe
P C
PC
Ekechukwu
A C
AC
Ogamba
O J
OJ
D000596:Amino Acids / Q000627:therapeutic use*; D000740:Anemia / Q000139:chemically induced* / Q000188:drug therapy*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D001835:Body Weight; D002701:Chloramphenicol / Q000009:adverse effects* / Q000627:therapeutic use; D005998:Glycine / Q000627:therapeutic use; D010649:Phenylalanine / Q000627:therapeutic use; D051381:Rats; D012485:Salmonella typhi; D014435:Typhoid Fever / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D010649:Phenylalanine; D002701:Chloramphenicol; D005998:Glycine