title: [Ultrastructural peculiarities of heart of rats of various ages at different levels of antigen load].
abstract: The aim of the research was to investigate electron-microscopic peculiarities of heart at different levels of antigen loading using adult and old aged gnotobiont rats, conventional rats and rats with experimental autoimmune cardiomyopathy. The results of investigations showed that the ultrasrtuctural characteristics of heart greatly depend on microbiological status and age of experimental animals. The ultrasrtucture of heart of adult rats mostly depend on the level of intensity of antigen loading. In all experimental groups of old rats the subcellular differences had the same directions. Although, it must be mentioned that there was not significant correlation between the level of heart damage and intensity of antigen loading. According to this, age-related changes depend not only on microbiological status of organism, but on genetically determined peculiarities of internal regulative processes taking place during the ontogenesis. Thus, the received results may be used to identify age-related changes, which give us the possibility for the differentiation between age-related and pathological peculiarities.
authors.forename: B K
authors.initials: BK
authors.lastname: Kochlamazashvili
authors.forename: L E
authors.initials: LE
authors.lastname: Gogiashvili
authors.forename: K N
authors.initials: KN
authors.lastname: Ddzhandieri
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D005260:Female; D006352:Heart Ventricles / Q000276:immunology* / Q000648:ultrastructure*; D008297:Male; D008929:Mitochondria, Heart / Q000276:immunology* / Q000648:ultrastructure*; D009206:Myocardium / Q000276:immunology* / Q000648:ultrastructure*; D009210:Myofibrils / Q000276:immunology* / Q000648:ultrastructure*; D051381:Rats
chemical_list: D000941:Antigens