Outcome of surgical treatment of synchronous liver metastases from colorectal cancer.
BACKGROUND
We retrospectively identified the prognostic factors in cases of synchronous liver metastases from colorectal cancer and established a clinical strategy at our institution.


METHODS
One hundred eight patients with hepatic metastases from colorectal cancer underwent a first radical hepatic resection. Of these, 67 were diagnosed with hepatic synchronous metastases from colorectal primaries (S group) and 41 were diagnosed with metachronous metastases (M group). Hepatic lesions were diagnosed concurrently with the primary lesions in 45 of the 67 patients in the S group. Of these 45 patients, 37 underwent synchronous hepatectomy (SH group) and 8 underwent metachronous hepatectomy (MH group).


RESULTS
The overall 3-, 5- and 10-year survival rates were 51.4%, 41.6%, and 30.9%, respectively. There were no significant differences between the S and M groups in overall survival. Univariate analysis of the S group revealed significant differences in survival based on tumor factor, pathological lymph node metastases of the primary tumor, and the tumor-free margin. There were no significant differences between the SH and MH groups in overall survival.


CONCLUSIONS
Patients with synchronous liver metastases from colorectal cancer should undergo radical resection of the primary lesion and simultaneous hepatectomy with an adequate tumor-free margin as a standard surgical course.
Taniai
Nobuhiko
N
Surgery for Organ Function and Biological Regulation, Nippon Medical School Graduate School of Medicine, Sendagi, Tokyo, Japan. Taniain@nms.ac.jp
Yoshida
Hiroshi
H
Mamada
Yasuhiro
Y
Matsumoto
Satoshi
S
Mizuguchi
Yoshiaki
Y
Suzuki
Hideyuki
H
Furukawa
Kiyonori
K
Akimaru
Koho
K
Tajiri
Takashi
T
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery*