title: Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine.
abstract: Coscinium fenestratum is a common medicinal plant widely used in the Indochina region, but scientific data on its safety is very limited. This study aimed to observe the effect of this plant on neurotoxicity and neurobehavior. Oral administration of plant alcoholic extract at dosages of 5, 10 and 20 mg/kgBW for 14 days increased the rats body weight and decreased the neuron density in the cerebral cortex, hippocampus and striatum. The plant extract significantly increased stereotyped behavior in licking but did not cause anxiolytic activity, anti-depression, sensory motor co-ordination impairment and ataxia. It is concluded that the plant possesses neurotoxicity and is able to induce neurobehavioral changes in rats. Therefore, the application of this plant as either drug or supplementary food should be reconsidered.
authors.affiliation: Department of Physiology, Faculty of Medicine, Khon Kaen University, 40000, 66-43-348394, Thailand. jintanapornw@yahoo.com
authors.forename: Jintanaporn
authors.initials: J
authors.lastname: Wattanathorn
authors.forename: Nongnut
authors.initials: N
authors.lastname: Uabundit
authors.forename: Wanchai
authors.initials: W
authors.lastname: Itarat
authors.forename: Supaporn
authors.initials: S
authors.lastname: Mucimapura
authors.forename: Pisamai
authors.initials: P
authors.lastname: Laopatarakasem
authors.forename: Bungorn
authors.initials: B
authors.lastname: Sripanidkulchai
mesh_terms: D000818:Animals; D001259:Ataxia / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D003342:Corpus Striatum / Q000187:drug effects / Q000473:pathology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D029583:Menispermaceae / Q000737:chemistry*; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D010936:Plant Extracts / Q000633:toxicity*; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013785:Thailand
chemical_list: D010936:Plant Extracts