Translational research in childhood obesity prevention.
This article explores the state of translational research in childhood obesity prevention. Five phases of translational research and emerging findings from basic science that could be useful in the design of obesity prevention programs are described. Few intervention studies have been published, and these are dominated by Phase 3 trials (efficacy), conducted in school settings, with a limited number of studies finding significant effects on Body Mass Index or adiposity. Cost-benefit analyses are lacking. Research is needed to translate basic science findings into novel interventions (Phases 1 and 2) and to translate programs with known behavior change capability into dissemination trials (Phase 5). Translation can be facilitated by enhanced communication between basic science and prevention science researchers, the development of interventions for underused settings, using novel strategies, support by institutions and funding agencies for translation, and the design of interventions with translation in mind.
Reynolds
Kim D
KD
University of Southern California, Institute for Health Promotion and Disease Prevention Research, Alhambra, CA 91803, USA. kdreynol@usc.edu
Spruijt-Metz
Donna
D
D000293:Adolescent; D035841:Behavioral Research / Q000379:methods* / Q000639:trends; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D002648:Child; D002662:Child Health Services / Q000592:standards*; D002986:Clinical Trials as Topic; D003299:Cooperative Behavior; D019317:Evidence-Based Medicine; D006801:Humans; D009765:Obesity / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D016730:Program Development / Q000592:standards*; D012572:School Health Services / Q000592:standards*; D016896:Treatment Outcome; D014481:United States