Role of mitochondria in multiple sclerosis.
This review presents inherited and acquired forms of mitochondrial dysfunction associated with oligodendrocytopathy and neurodegeneration in order to better understand the degenerative features of inflammatory demyelination. The recognition that various mitochondrial mechanisms are involved in the pathogenesis of multiple sclerosis leads to therapeutic considerations, re-emphasizing the importance of early neuroprotection in combination with the approved means of immune modulation.
Kalman
Bernadette
B
Department of Neurology, Saint Luke's Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY 10019, USA. bkalman@chpnet.org
D004272:DNA, Mitochondrial; D006801:Humans; D007249:Inflammation; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D009154:Mutation; D010084:Oxidation-Reduction
D004272:DNA, Mitochondrial