title: Effect of serial microdermabrasion on the ceramide level in the stratum corneum.
abstract: BACKGROUND
  Microdermabrasion has become a popular method for superficial resurfacing of the epidermis. Despite the popularity of this technique, few studies have examined changes in the levels of lipids (especially ceramide) in the stratum corneum following microdermabrasion.
  
  
  OBJECTIVE
  To assess and analyze changes in the ceramide level in the stratum corneum during the course of serial aluminum oxide microdermabrasion.
  
  
  METHODS
  Eleven healthy volunteers were enrolled in this study. Each participant underwent microdermabrasion once a week for 5 weeks. Following each procedure, the ceramide level in the resulting epidermal scales was measured.
  
  
  RESULTS
  A statistically significant increase in the ceramide level in the stratum corneum was observed following the first and second microdermabrasion sessions. After the third and fourth sessions, the ceramide level returned to baseline.
  
  
  CONCLUSIONS
  The results suggest that microdermabrasion alters the epidermal ceramide level. These findings provide the first evidence of alterations in the lipid barrier following microdermabrasion.
authors.affiliation: Department of Dermatology, College of Medicine, Kyunghee University, Seoul, Korea. bellotte@hanmail.net
authors.forename: Bark-lynn
authors.initials: BL
authors.lastname: Lew
authors.forename: Yunhi
authors.initials: Y
authors.lastname: Cho
authors.forename: Mu-hyoung
authors.initials: MH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000537:Aluminum Oxide; D044466:Asian People; D002518:Ceramides / Q000378:metabolism*; D003869:Dermabrasion; D004817:Epidermis / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D019233:Retreatment
chemical_list: D002518:Ceramides; D000537:Aluminum Oxide