title: Dealing with non-cancerous findings on prostate biopsy.
abstract: Most prostate biopsies do not show malignancy. The proper management of non-cancerous pathologic findings of the prostate is controversial. For this article, we reviewed the current literature for indications for repeat prostate biopsy after initial biopsies demonstrated non-cancerous prostatic tissue or benign prostatic hyperplasia. This review includes discussions of management of asymptomatic prostatitis and how it may affect prostate-specific antigen, and also the management of several potentially premalignant lesions such as atrophy, atypical small acinar proliferation, and high-grade prostatic intraepithelial neoplasia. There is a paucity of randomized trials in this area and, considering the high number of biopsies with non-malignant findings, we conclude that more investigation is warranted in this area.
authors.affiliation: Department of Urology, University of Texas Health Science Center, Mail Code 7845, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. brandt2@uthscsa.edu
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Brand
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Thibault
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Basler
mesh_terms: D001706:Biopsy; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D011469:Prostatic Diseases / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology