Neural correlates of Chinese word-appropriateness judgment: an MEG study.
To study the neural correlates of Chinese word-appropriateness judgment, we used 2-word phrases and corresponding meaningless pairs produced by replacing the second words (W2) with homophones. Fourteen right-handed healthy adults viewed word pairs randomly presented one word at a time, and judged the lexical appropriateness of the W2 for combining its preceding first word (W1) into a meaningful phrase. We measured magnetoencephalographic (MEG) responses to W1, appropriate W2, and inappropriate W2 stimuli. For each subject, multi-dipole analyses revealed sequential neuromagnetic activations which involved the bilateral visual cortices at approximately 100 milliseconds (ms), the bilateral occipitotemporal regions at approximately 190 ms, and the left temporal lobe at approximately 350 ms (M350) following stimuli. We found that the word appropriateness had no clear effect on the occipitotemporal activation to W2 stimuli, whereas the M350 activation to inappropriate W2 was greater than that to W1 or appropriate W2. In 8 of our subjects, we found an additional activation in the right temporal region, with a smaller amplitude as compared with the left M350. Our results suggest that the M350 activity reflects both lexical and semantic appropriateness assessment. The lateralized M350 strengths may be used to determine the language dominance hemisphere; and additionally, our 2-word contexture judgment paradigm can be applied in further research on the cortical processing of lexicon-semantic information in Chinese speakers.
Lin
Yung-Yang
YY
Institute of Physiology, National Yang-Ming University, Taipei, Taiwan. yylin@vghtpe.gov.tw
Liao
Kwong-Kum
KK
Chen
Jen-Tse
JT
Yeh
Tzu-Chen
TC
Shih
Yang-Hsin
YH
Wu
Zin-An
ZA
Ho
Low-Tone
LT
D000328:Adult; D044466:Asian People; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007600:Judgment / Q000502:physiology*; D007807:Language Tests; D015225:Magnetoencephalography; D008297:Male; D008606:Mental Processes; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012660:Semantics; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000502:physiology; D013997:Time Factors; D014705:Verbal Behavior