title: An astroblastoma case associated with loss of heterozygosity on chromosome 9p.
abstract: The tumorigenesis of astroblastomas has not yet been elucidated on the basis of histopathological studies, and genetic studies may be useful for obtaining additional information regarding the tumorigenesis of these tumors. Here, we report an astroblastoma case in which a genetic analysis was performed. A 16-year-old female with a progressive headache was found to have a demarcated cystic tumor with a mural nodule in the right parietal lobe. Total removal of the tumor was achieved and a histological examination verified that the tumor was an astroblastoma. A genetic analysis using microsatellite markers revealed loss of heterozygosity (LOH) on chromosome 9p. The postoperative course was uneventful and, to date, she has been followed up for 2 years with no signs of recurrence. This is the first reported case of an astroblastoma in which LOH was detected on 9p. Based on this result, the tumorigenesis of astroblastomas is discussed.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hata
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Shono
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mizoguchi
authors.forename: Tadao
authors.initials: T
authors.lastname: Kawamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Toru
authors.initials: T
authors.lastname: Iwaki
authors.forename: Tomio
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D019656:Loss of Heterozygosity; D008279:Magnetic Resonance Imaging; D018302:Neoplasms, Neuroepithelial / Q000150:complications / Q000235:genetics*; D010296:Parietal Lobe / Q000473:pathology