Benazepril hydrochloride: effects of particle size on tablet properties.
Tablets manufactured from fine powder (average particle size, D[4,3] = 50.1 microm) benazepril hydrochloride exhibited unacceptable processing and quality properties whereas microcrystalline material (D[4,3] = 4.5-7.7 microm) furnished a product with good processing and quality characteristics.
Eyjolfsson
R
R
Drug Development, Hafnarfjordur, Iceland. reynirey@mmedia.is
D000465:Algorithms; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000737:chemistry*; D001552:Benzazepines / Q000008:administration & dosage* / Q000737:chemistry*; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D010316:Particle Size; D013607:Tablets
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D013607:Tablets; D002482:Cellulose; C109691:microcrystalline cellulose; C044946:benazepril