The pheromone response pathway of Kluyveromyces lactis.
The mating pheromone response pathway in Saccharomyces cerevisiae is one of the best understood signalling pathways in eukaryotes. Comparison of this system with pathways in other fungal species has generated surprises and insights. Cloning and targetted disruption of genes encoding components of the pheromone response pathway has allowed the attribution of specific functions to these signal transduction components. In this review we describe current knowledge of the Kluyveromyces lactis mating system, and compare it with the well-understood S. cerevisiae pathway, emphasizing the similarities and differences in the heterotrimeric G protein activity. This mating pathway is controlled positively by both the Galpha and the Gbeta subunits of the heterotrimeric G protein.
Coria
Roberto
R
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, DF, Mexico. rcoria@ifc.unam.mx
Kawasaki
Laura
L
Torres-Quiroz
Francisco
F
Ongay-Larios
Laura
L
Sánchez-Paredes
Edith
E
Velázquez-Zavala
Nancy
N
Navarro-Olmos
Rocio
R
Rodríguez-González
Miriam
M
Aguilar-Corachán
Rodrigo
R
Coello
Gerardo
G
D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology; D007716:Kluyveromyces / Q000235:genetics / Q000502:physiology*; D010675:Pheromones / Q000235:genetics / Q000502:physiology*; D043563:Receptors, Pheromone / Q000502:physiology; D020218:Response Elements; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
D010675:Pheromones; D043563:Receptors, Pheromone; D020962:Heterotrimeric GTP-Binding Proteins