[Relationship between nitrogen oxide and the degree of metabolic control of diabetes mellitus type 1 in children and adolescents].
Diabetes mellitus is a disease with early endothelium injury. The most important damaging reactions of endothelium may be the abnormal synthesis of nitrogen oxide. The aim of the study was the evaluation of nitrogen oxide serum concentration in young patients with diabetes mellitus type 1 depending on glycated haemoglobin (HbA1c) concentration and parameters of lipoproteins metabolism.


METHODS
Ninety one children and adolescents (36/55, M/F) in the age 13.0 +/- 3.5 y., with mean diabetes duration 3.2 +/- 3.8 were examined. The control group consisted of 23 healthy volunteers. The degree of glycaemic control was taken into account (subgroup I - good glycaemic control HbA1c < 6.5%; II--sufficient HbA1c < or = 8.0% and III--poor glycaemic control HbA1c > 8.0%). Venous blood was used as a diagnostic material. In all cases fasting nitrogen oxide concentration measured indirectly by the level of nitrites (NO2-) and nitrates (NO3-) (micromol/L); triglycerides, total cholesterol, LDL and HDL cholesterol (mmol/L) were assessed.


RESULTS
The mean NO2- (59.20 +/- 56.77) and NO3- (53.90 +/- 56.63) concentrations were the highest in subgroup III (HbA1c- 9.72 +/- 1.21; T-Ch 5.40 +/- 1.04; TGL 2.11 +/- 1.54; LDL-Ch 3.07 +/- 0.91; HDL-Ch 0.97 +/- 0.19) and differed significantly (p = 0.004) from the results of patients with good glycaemic control- subgroup I (HbA1c < 6.37 +/- 0.17; T-Ch 4.6 +/- 1.13; TGL 1.59 +/- 1.74; LDL-Ch 1.64 +/- 0.72; HDL-Ch 1.10 +/- 0.17) and healthy individuals (p = 0.006). In the subgroup II mean NO2-(42.31 +/- 23.23) and NO3- (37.28 +/- 22.70) were high too, but statistical significance was stated only with subgroup I (p = 0.003) and healthy individuals (p = 0.001). The positive correlation (p < 0.005) was observed between NO2- and NO3- concentration and diabetes duration, HbA1c and LDL-Ch in all examined patients and in the subgroup II between triglycerides and LDL-Ch concentration and negative one with HDL-cholesterol.


CONCLUSIONS
Obtained results indicate significant correlation between examined parameters of metabolic control and nitrogen oxide concentration. This confirms the necessity of constant good metabolic control of diabetes mellitus.
Iwanicka
Zdzisława
Z
Katedry i Kliniki Endokrynologii Wieku Rozwojowego oraz, Akademii Medycznej we Wrocławiu.
Lewandowicz-Uszyńska
Aleksandra
A
Głab
Ewa
E
Kotschy
Bozena
B
D000293:Adolescent; D000328:Adult; D002648:Child; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D009569:Nitric Oxide