Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats.
Plasma histamine levels were measured in 11 clinically healthy cats and 15 cats with allergic dermatitis. Histamine levels were markedly elevated in 5/15 allergic cats. A calcium ionophore, A23187, stimulates histamine release from feline peripheral blood cells. Immunostaining of blood smears from clinically healthy cats revealed that approximately 10% of eosinophils possessed histamine-containing granules. These results indicate that some peripheral eosinophils in cats contain histamine and can release histamine by appropriate stimulation.
Kadoya
Michiyo
M
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
Momoi
Yasuyuki
Y
Iwasaki
Toshiroh
T
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002371:Cat Diseases / Q000276:immunology* / Q000473:pathology; D002415:Cats; D017449:Dermatitis, Allergic Contact / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006632:Histamine / Q000097:blood*; D006636:Histamine Release; D008297:Male; D015203:Reproducibility of Results
D015415:Biomarkers; D006632:Histamine