[Anti-neutrophil cytoplasmic antibody MPO-ANCA related with disease activity of vasculitis].
Myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) are involved in the development of vasculitis microscopic polyangiitis, a systemic vasculitis etc. We have showed a correlation of MPO-ANCA epitopes in vasculitis concerning contribution of N and C terminus of MPO to severity of the diseases. On the other hand, a role of activated neutrophils in inflammatory nephritis renal lesions using SCG/Kj mice. In the phase of nephritis with a low grade of proteinuria, the spontaneous release of MPO from peripheral neutrophils increased, indicating that neutrophils are activated and contribute to the development of active crescentic lesions in SCG/Kj mice. In addition, we have investigated that mice having CADS/CAWS-induced vasculitis also are good model animals for the analysis of the production of MPO-ANCA. Furthermore, we have clarified that MPO is a major antigen for MPO-ANCA production using MPO knock mice.
Suzuki
Kazuo
K
Department of Bioactive Molecules, National Institute of Infectious Diseases.
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D000939:Epitopes; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018375:Neutrophil Activation / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D009195:Peroxidase / Q000737:chemistry / Q000276:immunology*; D014657:Vasculitis / Q000201:enzymology / Q000209:etiology / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D000939:Epitopes; D009195:Peroxidase