Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor.
Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.
Cao
Shugeng
S
MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II, Singapore 117528.
Low
Kia-Ngee
KN
Glover
Robert P
RP
Crasta
Sharon C
SC
Ng
Siewbee
S
Buss
Antony D
AD
Butler
Mark S
MS
D029759:Calophyllum / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors*; D012846:Singapore; D014407:Tumor Cells, Cultured
D011965:Receptors, Glucocorticoid; C511037:sundaicumone A; C511038:sundaicumone B; D010696:Phloroglucinol