title: Peri-implant inflammation defined by the implant-abutment interface.
abstract: An implant-abutment interface at the alveolar bone crest is associated with sustained peri-implant inflammation; however, whether magnitude of inflammation is proportionally dependent upon interface position remains unknown. This study compared the distribution and density of inflammatory cells surrounding implants with a supracrestal, crestal, or subcrestal implant-abutment interface. All implants developed a similar pattern of peri-implant inflammation: neutrophilic polymorphonuclear leukocytes (neutrophils) maximally accumulated at or immediately coronal to the interface. However, peri-implant neutrophil accrual increased progressively as the implant-abutment interface depth increased, i.e., subcrestal interfaces promoted a significantly greater maximum density of neutrophils than did supracrestal interfaces (10,512 +/- 691 vs. 2398 +/- 1077 neutrophils/mm(2)). Moreover, inflammatory cell accumulation below the original bone crest was significantly correlated with bone loss. Thus, the implant-abutment interface dictates the intensity and location of peri-implant inflammatory cell accumulation, a potential contributing component in the extent of implant-associated alveolar bone loss.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center at San Antonio, 78229, USA.
authors.forename: N
authors.initials: N
authors.lastname: Broggini
authors.forename: L M
authors.initials: LM
authors.lastname: McManus
authors.forename: J S
authors.initials: JS
authors.lastname: Hermann
authors.forename: R
authors.initials: R
authors.lastname: Medina
authors.forename: R K
authors.initials: RK
authors.lastname: Schenk
authors.forename: D
authors.initials: D
authors.lastname: Buser
authors.forename: D L
authors.initials: DL
authors.lastname: Cochran
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology*; D000818:Animals; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D015921:Dental Implants / Q000009:adverse effects*; D017267:Dental Prosthesis Design / Q000009:adverse effects; D004285:Dogs; D007958:Leukocyte Count; D008297:Male; D008336:Mandibular Diseases / Q000209:etiology; D009504:Neutrophils; D010518:Periodontitis / Q000209:etiology*; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants