Sometimes intermediates. Do the job!
The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .
Hilgenfeld
Rolf
R
Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Pumpor
Ksenia
K
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology; D000086782:Coronavirus 3C Proteases; D003546:Cysteine Endopeptidases / Q000737:chemistry; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D061466:Lopinavir; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects* / Q000472:pathogenicity; D013379:Substrate Specificity
D000998:Antiviral Agents; D052160:Benzothiazoles; D004952:Esters; D011480:Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D003546:Cysteine Endopeptidases; D000086782:Coronavirus 3C Proteases