title: Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines.
abstract: Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.
authors.affiliation: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
authors.forename: Naisheng
authors.initials: N
authors.lastname: Bai
authors.forename: Ching-Shu
authors.initials: CS
authors.lastname: Lai
authors.forename: Kan
authors.initials: K
authors.lastname: He
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Quan
authors.forename: Nanqun
authors.initials: N
authors.lastname: Zhu
authors.forename: Qun Yi
authors.initials: QY
authors.lastname: Zheng
authors.forename: Min-Hsiung
authors.initials: MH
authors.lastname: Pan
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D006801:Humans; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes