title: The anti-Helicobacter pylori flavones in a Brazilian plant, Hyptis fasciculata, and the activity of methoxyflavones.
abstract: Two known flavonoids were isolated from a tropical medicinal plant, Hyptis fasciculata (Labiatae), found in Brazil. Flavonoids were identified as cirsilineol (1) and cirsimaritin (2) by spectroscopic means and were exhibited potent antibacterial activity against Helicobacter pylori, and cirsilineol (1) had weak antibacterial activity against Escherichia coli and Salmonella enteritidis. Following up on the relationship between anti-H. pylori activity and flavonoids with methoxy groups, several methoxy flavonoids were evaluated for proliferation of H. pylori.
authors.affiliation: Department of Chemistry, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. isobetkh@hyo-med.ac.jp
authors.forename: Takahiko
authors.initials: T
authors.lastname: Isobe
authors.forename: Matsumi
authors.initials: M
authors.lastname: Doe
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nagata
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001938:Brazil; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D031331:Hyptis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D047309:Flavones; D010936:Plant Extracts