title: Laboratory evaluation of the bioinsecticide Spinosad for mosquito control.
abstract: Spinosad, a naturally occurring product of the fermentation of the bacterium Saccharopolyspora spinosa, is a highly effective bioinsecticide against a broad range of agriculturally important insect pests, and this agent has an excellent environmental and mammalian toxicological profile. In this study the efficacy of a Spinosad-based product (Laser 4.8% emulsifiable concentrate) was evaluated in laboratory bioassays against laboratory-reared mosquito strains of 3 species of medical importance: Aedes aegypti, Anopheles stephensi, and Culex pipiens. Spinosad was particularly effective against larval Aedes and Culex, with a less marked activity against anophelines (24-h median lethal concentration = 0.0096, 0.0064, and 0.039 mg/liter, respectively), showing a persistence of the insecticide action of about 6 wk in laboratory containers. The activity of the Spinosad-based product against adult mosquitoes (toxicity by ingestion and a possible irritant or repellent effect on gravid females) also was evaluated. Results are discussed and compared with those available in the literature.
authors.affiliation: Department of Infectious, Parasitological and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Roma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Romi
authors.forename: S
authors.initials: S
authors.lastname: Proietti
authors.forename: M
authors.initials: M
authors.lastname: Di Luca
authors.forename: M
authors.initials: M
authors.lastname: Cristofaro
mesh_terms: D000330:Aedes; D000818:Animals; D000852:Anopheles; D003465:Culex; D004338:Drug Combinations; D007306:Insecticides; D007814:Larva; D018942:Macrolides; D010058:Oviposition / Q000187:drug effects; D010063:Ovum / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D007306:Insecticides; D018942:Macrolides; C415329:spinosad