Family size in women with polycystic ovary syndrome.
Given that polycystic ovary syndrome (PCOS) is associated with oligo-ovulatory infertility and is an inherited trait, we hypothesized that the families of patients with PCOS are smaller than those of matched controls. However, our study of 106 white patients with PCOS, ages 18-45, and 53 healthy eumenorrheic nonhirsute white controls did not indicate a difference in family size between the groups; these results have important implications for the design of prospective studies of the heritability and genetics of PCOS.
Pall
Marita
M
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Stephens
Kelley
K
Azziz
Ricardo
R
D000293:Adolescent; D017677:Age Distribution; D000407:Alabama / Q000453:epidemiology; D016022:Case-Control Studies; D005191:Family Characteristics; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors