title: [Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project].
abstract: OBJECTIVE
  To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs.
  
  
  METHODS
  Molecular epidemiology study.
  
  
  METHODS
  S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs.
  
  
  METHODS
  50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits.
  
  
  METHODS
  Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2).
  
  
  RESULTS
  19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups.
  
  
  CONCLUSIONS
  This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.
authors.affiliation: Struttura di cancerogenesi ambientale, Istituto nazionale per la ricerca sul cancro, Genova. claudia.bolognesi@istge.it
authors.forename: Claudia
authors.initials: C
authors.lastname: Bolognesi
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Nucci
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Colacci
authors.forename: Sandro
authors.initials: S
authors.lastname: Grilli
authors.forename: Flora
authors.initials: F
authors.lastname: Ippoliti
authors.forename: Nicolina
authors.initials: N
authors.lastname: Mucci
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Romano Spica
authors.forename: Anna
authors.initials: A
authors.lastname: Barbieri
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Canitano
authors.forename: Daniela
authors.initials: D
authors.lastname: Chiozzotto
authors.forename: Livia
authors.initials: L
authors.lastname: Di Renzo
authors.forename: Elena
authors.initials: E
authors.lastname: Giordano
authors.forename: Wolfango
authors.initials: W
authors.lastname: Horn
authors.forename: Paola
authors.initials: P
authors.lastname: Roggieri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Risi
authors.forename: Paola
authors.initials: P
authors.lastname: Silingardi
authors.forename: Monica
authors.initials: M
authors.lastname: Vaccari
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Violante
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000652:urine*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D009726:Nurses; D016273:Occupational Exposure / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents