title: Recurrent episodes of intractable laryngospasm during dissociative sedation with intramuscular ketamine.
abstract: We report 2 cases of dissociative sedation with intramuscular ketamine with recurrent episodes of laryngospasm that we were unable to ventilate with bag-mask ventilation, in 1 case leading to endotracheal intubation to protect the airway. Supplemental oxygen was given throughout the sedations, and ventilatory status was noninvasively monitored on a continuous basis, providing detailed and objective documentation of the patients' clinical status throughout the sedations. We were, therefore, able to rapidly assess and confirm apnea, laryngospasm, and airway dysfunction.
authors.affiliation: Department of Pediatrics, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Virginia Grace
authors.initials: VG
authors.lastname: Cohen
authors.forename: Baruch
authors.initials: B
authors.lastname: Krauss
mesh_terms: D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D005151:Facial Injuries / Q000628:therapy; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007442:Intubation, Intratracheal; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects*; D007826:Laryngismus / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000778:Anesthetics, Dissociative; D007649:Ketamine