title: Sudden cardiac arrest in an intubated premature infant with cerebellar and brainstem injury: is there a link?
abstract: The ventilated premature infant frequently exhibits unprovoked desaturation episodes accompanied by bradycardia. In most instances, these episodes are short-lived and recover spontaneously or with minimal interventions. However, in some infants these episodes may be more profound and require substantial interventions to restore cardiorespiratory status. Here we present the case of a ventilated premature infant who had experienced prolonged, multiple daily desaturation episodes accompanied by bradycardia that required significant interventions. Postoperatively, after placement of a tracheotomy and despite a patent airway, the infant developed acute bradycardia that progressed rapidly to sudden death. At autopsy, significant cerebellar and brainstem injury was noted. We hypothesize that the specific cerebellum and brainstem injury may have contributed to autonomic dysfunction and sudden death.
authors.affiliation: Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA.
authors.forename: R Victoria
authors.initials: RV
authors.lastname: Chen
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Perlman
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D001919:Bradycardia / Q000209:etiology; D001933:Brain Stem / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D002544:Cerebral Infarction / Q000150:complications; D016757:Death, Sudden, Cardiac; D006323:Heart Arrest / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000473:pathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008297:Male; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy