title: [The synthesis of immunomodulating peptide alloferon, the active component of the antiviral drug allokine-alpha].
abstract: Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total yield (40% vs. 17% for conventional synthesis in solution from the starting derivatives of the C-terminal dipeptide). The by-products formed during the synthesis of alloferon were identified.
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.forename: A S
authors.initials: AS
authors.lastname: Molokoedov
authors.forename: E V
authors.initials: EV
authors.lastname: Kudriavtseva
authors.forename: M I
authors.initials: MI
authors.lastname: Baldin
authors.forename: D A
authors.initials: DA
authors.lastname: Frid
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: V N
authors.initials: VN
authors.lastname: Bushuev
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D000276:Adjuvants, Immunologic; C510535:Alloferon; D000998:Antiviral Agents; D010455:Peptides