title: Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.
abstract: Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (-)-jorumycin (1) and (-)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (-)-Jorumycin (1) displayed potent growth inhibition with GI50 values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI50 0.6-14.0 microM).
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Lane
authors.forename: Alberto
authors.initials: A
authors.lastname: Estevez
authors.forename: Kyle
authors.initials: K
authors.lastname: Mortara
authors.forename: Ondine
authors.initials: O
authors.lastname: Callan
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Spencer
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C507299:3-epi-jorumycin; C507298:3-epi-renieramycin G; D000970:Antineoplastic Agents; D044005:Tetrahydroisoquinolines