Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.
Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.
Storz
Peter
P
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Jacksonville, FL 32224, USA. storz.peter@mayo.edu
D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000209:etiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
D017382:Reactive Oxygen Species