Dopaminergic neurons reduced to silence by oxidative stress: an early step in the death cascade in Parkinson's disease?
Parkinson's disease (PD) is a common neurodegenerative disorder that is most often sporadic, but in some cases it can be inherited as a simple Mendelian trait. The most important pathological feature of the disease is the death of brainstem dopaminergic neurons in the substantia nigra, which leads to characteristic motor symptoms. The etiology of PD remains unknown, but mitochondrial dysfunction and oxidative stress may contribute actively to the underlying pathomechanism. New studies suggest that K(ATP) channel activation may represent a downstream effector of these two cellular anomalies.
Michel
Patrick P
PP
INSERM U679, Experimental Neurology and Therapeutics, 75013 Paris, France. ppmichel@ccr.jussieu.fr
Ruberg
Merle
M
Hirsch
Etienne
E
D000818:Animals; D016923:Cell Death; D004298:Dopamine / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction
D004298:Dopamine