A new eudesmane derivative and a new fatty acid ester from Sambucus williamsii.
1,4,13-Trihydroxy-eudesm-11(12)-ene, a new eudesmane derivative (3), (9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester, a new fatty acid ester (2) and tianshic acid (1) were obtained from the stems of Sambucus williamsii. Their structures were elucidated by physiochemical properties and spectroscopic analysis. Both compounds 1 and 2 showed stimulating effects on alkaline phosphatase activity of the osteoblastic UMR106 cell about 1.5 fold at 30 mumol/l while they had no effects on cell proliferation.
Yang
Xujuan
X
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015, China.
Wong
Mansau
M
Wang
Naili
N
Chan
Albert Sun-Chi
AS
Yao
Xinsheng
X
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005227:Fatty Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D027923:Sambucus / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
C511332:1,4,13-trihydroxy-eudesm-11(12)-ene; C511333:8,11,12-trihydroxyoctadecenoic acid methyl ester; D000972:Antineoplastic Agents, Phytogenic; D005227:Fatty Acids; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane; D000469:Alkaline Phosphatase