Granulomatous hepatitis and hemophagocytic syndrome after bacillus Calmette-Guerin bladder instillation.
Intravesical instillations of bacillus Calmette-Guérin are frequently used for treating superficial bladder carcinoma which is considered a safe treatment. We describe an unusual complication with hemophagocytosis and granulomatous hepatitis. Prompt diagnosis and treatment with corticosteroids, anti-tuberculous agents and intravenous immunoglobulins led to a rapid recovery.
Thevenot
Thierry
T
Service d'Hépatologie et de Soins Intensifs Digestifs, Centre Hospitalier Louis Pasteur, Dole. tthevenot@chu-besancon.fr
Di Martino
Vincent
V
Lagrange
Aurélie
A
Petrella
Tony
T
Faucher
Jean-François
JF
Fontan
Jean
J
Terebus
Mélanie
M
Miguet
Jean-Philippe
JP
Bresson-Hadni
Solange
S
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D006099:Granuloma / Q000209:etiology*; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D008297:Male
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine