title: Closed loops in anaesthesia.
abstract: Closed-loop systems are able to make their own decisions and to try to reach and maintain a preset target. As a result, they might help the anaesthetist to optimise the titration of drug administration without any overshoot, controlling physiological functions and guiding monitoring variables. Thanks to the development of fast computer technology and more reliable pharmacological effect measures, the study of automation in anaesthesia has regained popularity. This short review focuses on the most recently developed and tested feedback systems in anaesthesia. Various new approaches for controlling the administration of intravenous and inhaled hypnotic-anaesthetic drugs have recently been published. For analgesics, a framework for further research has been presented in the literature. For other drugs, such as muscle relaxants and haemodynamic agents, only short reviews can be found. Until now, most of these systems have had to be under development. The challenge is now fully to establish the safety, efficacy, reliability and utility of closed-loop anaesthesia so that it can be adopted in the clinical setting. Besides, their role in optimising the controlled variables and control models, these systems have to be tested in extreme circumstances in order to test their robustness.
authors.affiliation: Department of Anesthesia, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium. michel.struys@ugent.be
authors.forename: Michel M R F
authors.initials: MM
authors.lastname: Struys
authors.forename: Eric P
authors.initials: EP
authors.lastname: Mortier
authors.forename: Tom
authors.initials: T
authors.lastname: De Smet
mesh_terms: D000758:Anesthesia / Q000379:methods*; D001331:Automation / Q000379:methods*; D003201:Computers; D004333:Drug Administration Routes; D005246:Feedback / Q000502:physiology*; D006801:Humans