title: Interferon-alpha treatment of molluscum contagiosum in a patient with hyperimmunoglobulin E syndrome.
abstract: We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.
authors.affiliation: Department of Pediatrics, Uludag University School of Medicine, Bursa, Turkey. sebnemkl@uludag.edu.tr
authors.forename: Sara Sebnem
authors.initials: SS
authors.lastname: Kilic
authors.forename: Fatih
authors.initials: F
authors.lastname: Kilicbay
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007589:Job Syndrome / Q000150:complications*; D008297:Male; D008976:Molluscum Contagiosum / Q000188:drug therapy* / Q000209:etiology*; D012074:Remission Induction
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha