title: The epidemiology of Haemophilus influenzae type b meningitis in Burkina Faso.
abstract: BACKGROUND
  Haemophilus influenzae type b (Hib) disease burden studies are important to conduct in African countries that plan to introduce vaccine so that vaccine impact can be documented.
  
  
  METHODS
  We implemented population-based meningitis surveillance in 3 districts of Burkina Faso for 12 months each during 2002-2003 and 2004-2005 using polymerase chain reaction, culture and antigen detection.
  
  
  RESULTS
  Lumbar puncture was performed on 1686 patients and 112 had Hib identified. Persons <1, <5, 5-14 and 15+ years of age had annual Hib meningitis incidences of 97, 34, 2.1 and 0.55 per 100,000, respectively; overall case fatality proportion was 25%. During the historic meningitis epidemic season months of December through April, the proportion of purulent cerebrospinal fluid among children aged <5 years that yielded Hib was 27% compared with 30% during other months. Twenty-five of 98 persons with information available were treated with only one or 2 doses of oily chloramphenicol. Among children age <5 years with Hib meningitis, 28% were pretreated with antimalarials and antimalarial pretreatment was associated with delay in hospitalization.
  
  
  CONCLUSIONS
  In Burkina Faso, Hib meningitis incidence and case fatality proportion are high and thus vaccine could have a substantial impact. While awaiting well-implemented routine infant Hib vaccination, empiric case management for pediatric meningitis in sub-Saharan Africa must recognize that Hib is likely even during the epidemic season. In malaria-endemic areas, pediatric Hib meningitis case management may be adversely affected by the similar presentation of these 2 diseases.
authors.affiliation: Centre Muraz, Bobo-Dioulasso, Burkina Faso.
authors.forename: Seydou
authors.initials: S
authors.lastname: Yaro
authors.forename: Mathilde
authors.initials: M
authors.lastname: Lourd
authors.forename: B
authors.initials: B
authors.lastname: Naccro
authors.forename: Berthe-Marie
authors.initials: BM
authors.lastname: Njanpop-Lafourcade
authors.forename: Alain
authors.initials: A
authors.lastname: Hien
authors.forename: Macaire S
authors.initials: MS
authors.lastname: Ouedraogo
authors.forename: Yves
authors.initials: Y
authors.lastname: Traore
authors.forename: Leo M
authors.initials: LM
authors.lastname: Schouls
authors.forename: Isabelle
authors.initials: I
authors.lastname: Parent du Châtelet
authors.forename: Bradford D
authors.initials: BD
authors.lastname: Gessner
mesh_terms: D002050:Burkina Faso / Q000453:epidemiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002675:Child, Preschool; D003470:Culture Media; D005260:Female; D019741:Haemophilus influenzae type b / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D007841:Latex Fixation Tests; D008297:Male; D008583:Meningitis, Haemophilus / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D011159:Population Surveillance / Q000379:methods*
chemical_list: D003470:Culture Media