title: The dynamism of cutaneous lupus erythematosus: mild discoid lupus erythematosus evolving into SLE with SCLE and treatment-resistant lupus panniculitis.
abstract: We present a 47-year-old Caucasian female who initially presented with mild discoid lupus erythematosus that evolved into systemic lupus erythematosus with subacute cutaneous LE and treatment-recalcitrant lupus panniculitis. Conventional therapy with antimalarials, systemic steroids, azathioprine, cyclophosphamide, methotrexate, and pulse doses of methylprednisolone did not control the course of the disease. Cyclosporin-A treatment led to clinical improvement and maintained remission.
authors.affiliation: Department of Dermatology, Medical University of Lodz, Lodz, Poland, wozniacka@bmp.net.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Wozniacka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Salamon
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lesiak
authors.forename: Daniel Paul
authors.initials: DP
authors.lastname: McCauliffe
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jedrzejowska
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D015435:Panniculitis, Lupus Erythematosus / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D020551:Pulse Therapy, Drug; D016559:Tacrolimus / Q000008:administration & dosage; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D007166:Immunosuppressive Agents; D006886:Hydroxychloroquine; D016572:Cyclosporine; D003520:Cyclophosphamide; D001379:Azathioprine; D016559:Tacrolimus; D008775:Methylprednisolone; D008727:Methotrexate