title: Successful treatment of intracardiac progression and metachronous multiple brain metastases from primary lung cancer.
abstract: We report a rare case of squamous cell carcinoma of the lung extending into the left atrium via the pulmonary vein. The tumor tissue including the thrombus was resected en-bloc under cardiopulmonary bypass. Despite adjuvant chemotherapy, multiple brain metastases developed, but they were eradicated by stereotactic radiosurgery. The patient is still disease-free 48 months after the resection. This case serves to demonstrate the validity of multidisciplinary treatment for locally advanced lung cancer.
authors.affiliation: Division of Thoracic Surgery, Department of Medical Bioregulation, Yamaguchi University School of Medicine, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ueda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kaneda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakano
authors.forename: Toshiki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Saito
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Hamono
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000628:therapy*; D002315:Cardiopulmonary Bypass; D017024:Chemotherapy, Adjuvant; D005260:Female; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006338:Heart Neoplasms / Q000556:secondary / Q000628:therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000556:secondary / Q000628:therapy*; D011667:Pulmonary Veins / Q000473:pathology / Q000601:surgery; D016634:Radiosurgery; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D016190:Carboplatin; D000077235:Vinorelbine