Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases.
OBJECTIVE
The purpose of the study is to report two long-term survivors with ovarian carcinosarcomas, which are rare intrapelvic malignancies with unfavorable prognosis.


METHODS
Two middle-aged women with palpable abdominal tumors underwent complete cytoreductive surgery and no macroscopic tumor was left behind. Early postoperative intraperitoneal chemotherapy with doxorubicin was used as an adjuvant treatment.


RESULTS
The patients are disease-free 2 and 3 years, respectively after the initial therapy.


CONCLUSIONS
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy seems to be an effective treatment for ovarian carcinosarcoma with peritoneal spread. Further studies are required to define the value of intraperitoneal chemotherapy in ovarian carcinosarcoma.
Xanthoulis
A
A
Department of Surgery, Didimotichon General Hospital, Didimotichon, Greece. dr_xanthoulis@hotmail.com
Mirelis
Charalambos
C
Markakidis
Sotirios
S
Bougioukas
Ioannis
I
Bekiaridou
Konstantina
K
Tsalkidou
Evanthia
E
Zafeiropoulos
Georgios
G
Tentes
Antonios-Apostolos K
AA
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002296:Carcinosarcoma / Q000188:drug therapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery*; D011379:Prognosis; D017741:Survivors; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin