title: Multiple periungual pyogenic granulomas following systemic 5-fluorouracil.
abstract: A 65-year-old man presented with a 7-month history of eight bleeding periungual lesions on both feet. The clinical diagnosis of multiple pyogenic granulomas was confirmed by histological examination. Historically, the pyogenic granulomas appeared 3 months after commencing 5-fluorouracil chemotherapy for rectal carcinoma, suggesting a possible causative relationship. Chemotherapy was ceased by the supervising oncologist. Resolution occurred after two lesions had been treated with curettage and diathermy, and the remaining lesions with occlusive dressings over Kenacomb ointment (triamcinolone acetonide 0.1%, neomycin sulphate 0.25%, gramicidin 0.025%, nystatin 100,000 U/g) topically twice daily for a period of 3 months.
authors.affiliation: Department of Dermatology, The Alfred Hospital, Prahran, Victoria, Australia. nathancurr@hotmail.com
authors.forename: Nathan
authors.initials: N
authors.lastname: Curr
authors.forename: Helen
authors.initials: H
authors.lastname: Saunders
authors.forename: Anand
authors.initials: A
authors.lastname: Murugasu
authors.forename: Prasad
authors.initials: P
authors.lastname: Cooray
authors.forename: Max
authors.initials: M
authors.lastname: Schwarz
authors.forename: Douglas
authors.initials: D
authors.lastname: Gin
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D017789:Granuloma, Pyogenic / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D014034:Toes / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil