Mild cognitive impairment.
Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia.
Gauthier
Serge
S
McGill Center for Studies in Aging, Douglas Hospital, Montréal, Quebec, Canada. serge.gauthier@mcgill.ca
Reisberg
Barry
B
Zaudig
Michael
M
Petersen
Ronald C
RC
Ritchie
Karen
K
Broich
Karl
K
Belleville
Sylvie
S
Brodaty
Henry
H
Bennett
David
D
Chertkow
Howard
H
Cummings
Jeffrey L
JL
de Leon
Mony
M
Feldman
Howard
H
Ganguli
Mary
M
Hampel
Harald
H
Scheltens
Philip
P
Tierney
Mary C
MC
Whitehouse
Peter
P
Winblad
Bengt
B
D000368:Aged; D018680:Cholinergic Antagonists / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology; D003704:Dementia / Q000209:etiology*; D018450:Disease Progression; D006801:Humans; D008568:Memory; D012720:Severity of Illness Index
D018680:Cholinergic Antagonists