Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico.
As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.
Park
Young Chul
YC
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA.
Gunasekera
Sarath P
SP
Lopez
Jose V
JV
McCarthy
Peter J
PJ
Wright
Amy E
AE
D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C510827:7a(S)-p-hydroxyphenopyrrozin; D011758:Pyrroles