Levodopa-responsive parkinsonism associated with hydrocephalus.
We report on a patient who developed acute parkinsonian symptoms following shunt revision for hydrocephalus. Parkinsonism improved dramatically after levodopa therapy. Furthermore, there was no recurrence of Parkinsonism despite discontinuation of levodopa. This observation suggests that Parkinsonism in this patient was caused by reversible dysfunction of the presynaptic nigrostriatal dopaminergic pathway due to hydrocephalus.
Kim
Mi Jung
MJ
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Chung
Sun J
SJ
Sung
Young H
YH
Lee
Myoung C
MC
Im
Joo-Hyuk
JH
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000150:complications*; D007980:Levodopa / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*
D000978:Antiparkinson Agents; D007980:Levodopa