Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination.
Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.
Tasduq
S A
SA
Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, (CSIR), Canal Road, Jammu - Tawi 180 001, India.
Singh
K
K
Satti
N K
NK
Gupta
D K
DK
Suri
K A
KA
Johri
R K
RK
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000995:Antitubercular Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D005638:Fruit / Q000737:chemistry; D022781:Hepatocytes / Q000473:pathology; D007538:Isoniazid / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011718:Pyrazinamide / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D012293:Rifampin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D029766:Terminalia / Q000737:chemistry*
D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D004338:Drug Combinations; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin