title: Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment.
abstract: We compared plasma levels of beta-amyloid 1-42 (pg/ml) found for 146 sporadic Alzheimer (AD) patients, 89 subjects with mild cognitive impairment (MCI) and 89 age-matched controls (CT). AD patients had significantly lower levels (38, 54, 52; p<0.01), unrelated to severity of the disease as assessed by MMSE score, age, sex or APOE4 status. Twenty cases investigated at two time points 18 months apart did not demonstrate further decreases. Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease.
authors.affiliation: Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Pesaresi
authors.forename: Carlo
authors.initials: C
authors.lastname: Lovati
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Bertora
authors.forename: Enrico
authors.initials: E
authors.lastname: Mailland
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Quadri
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Claudio
authors.initials: C
authors.lastname: Mariani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000097:blood*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)