title: Advanced thyroid carcinoma: an experience of 385 cases.
abstract: OBJECTIVE
  To report clinical outcomes of a large series of cases with advanced thyroid cancer.
  
  
  METHODS
  Three hundred and eighty-five patients at the UICC stages III and IV were selected for the study with thyroid cancer.
  
  
  RESULTS
  Papillary carcinoma and sclerosing carcinoma have better survival than the Hürthle cell and insular types. Lymphatic metastasis does not appear to worsen the prognosis. All the tumour forms offer the chance of long survival.
  
  
  CONCLUSIONS
  Surgical treatment is the primary treatment of thyroid carcinoma. The combined treatments of surgery, metabolic beam therapy, suppressive hormone therapy, radiotherapy and chemotherapy cure a high percentage of patients with the tumour at an advanced stage.
authors.affiliation: Department of Surgical Pathology, University of Florence, Italy. giancarlo.freschi@unifi.it
authors.forename: G
authors.initials: G
authors.lastname: Freschi
authors.forename: L
authors.initials: L
authors.lastname: Landi
authors.forename: A
authors.initials: A
authors.lastname: Castagnoli
authors.forename: A
authors.initials: A
authors.lastname: Taddei
authors.forename: P
authors.initials: P
authors.lastname: Bechi
authors.forename: G
authors.initials: G
authors.lastname: Bucciarelli
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal