[Hysteroresection of submucous myomas after treatment with zoladex].
The early and heavy clinical symptoms of the submucous myomas demand early surgical intervention. The new alternative to the classical abdominal operation is the transcervical hysteroresection which is miniinvasive and organ-preserving procedure.


OBJECTIVE
to assess the effect of the preoperative treatment of the patients with Goserelin acetate (Zoladex) on the intraoperative measures (operation time, intraoperative complications, difficulty of the procedure).


METHODS
prospective. PATIENT(S) AND METHODS: Total of 50 women with submucous myomas underwent hysteroresection. Ten of them were treated with Zoladex for two months preoperatively.


RESULTS
In the treated group a mean decrease of 10.16 mm of the myoma diameter was achieved. This is especially important for myomas above 30 mm in diameter because 10 mm decrease in diameter leads to significant reduction of the tissue volume which has to be resected. In the treated group the mean operation time was decreased by 17.08 min. and the operation was assessed as "easier" in 90% of the cases. The authors assessed that the positive effect of Zoladex consists not only of the decreasing of the myoma diameter but also of achieving an endometrial atrophy which significantly improves the conditions for performing the intrauterine operation.


CONCLUSIONS
Hysteroscopic resection of submucous myomas after pretreatment with Zoladex is faster, easier and with less intraoperative complications.
Tiufekchieva
E
E
Nikolov
A
A
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D017273:Goserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015907:Hysteroscopy; D007889:Leiomyoma / Q000188:drug therapy / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery*
D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin