title: Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum.
abstract: Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205, Tampa, Florida 33620, USA.
authors.forename: Thushara
authors.initials: T
authors.lastname: Diyabalanage
authors.forename: Charles D
authors.initials: CD
authors.lastname: Amsler
authors.forename: James B
authors.initials: JB
authors.lastname: McClintock
authors.forename: Bill J
authors.initials: BJ
authors.lastname: Baker
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C522534:palmerolide A