title: Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors.
abstract: Considerable interest has been attracted in xanthone and its derivatives because of their large variety of pharmacological activities. In this project, a series of hydroxylxanthones and their acetoxy and alkoxy derivatives were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these xanthone derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities. Among them, polyhydroxylxanthones exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Zou
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Zun-Le
authors.initials: ZL
authors.lastname: Xu
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D044004:Xanthones