title: [Crohn's disease associated with IgA nephropathy].
abstract: Crohn's disease is a condition of chronic inflammation potentially involving any location of the alimentary tract from mouth to anus. Numerous extraintestinal manifestations can also be present. Urologic complications of inflammatory bowel disease are seen in up to 25% of patients, but renal parenchymal disease has been rarely reported. IgA nephropathy is recognized worldwide as a most common form of primary glomerulonephritis. Clinical manifestations vary, ranging from microscopic hematuria to nephrotic syndrome. Recently, IgA nephropathy associated with systemic diseases has been reported. We describe a case of a 22 year-old man with Crohn's disease associated with IgA nephropathy. At the age of 8 years, microscopic hematuria appeared. After fourteen years, he presented with melena, mild fever, recurrent oral ulcer, microscopic hematuria and proteinuria. Colonoscopic examination revealed characteristic features of Crohn's disease such as multiple ulcers. Microscopic findings showed superficial ulceration with small noncaseating granulomas. Renal biopsy revealed IgA nephropathy. The patient was treated with oral prednisolone, olsalazine, and metronidazole followed by maintenance therapy with sulfasalazine and azathioprine resulting in clinical improvement of Crohn's disease and IgA nephropathy.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Ji Youn
authors.initials: JY
authors.lastname: Youm
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Lee
authors.forename: Moon Hyang
authors.initials: MH
authors.lastname: Park
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Yang
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Han
authors.forename: Yoo Hum
authors.initials: YH
authors.lastname: Baek
authors.forename: Song Ree
authors.initials: SR
authors.lastname: Park
authors.forename: Hang Lack
authors.initials: HL
authors.lastname: Lee
authors.forename: Byoung Chul
authors.initials: BC
authors.lastname: Yoon
authors.forename: Ho Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Hahm
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Dong Hoo
authors.initials: DH
authors.lastname: Lee
authors.forename: Chun Suk
authors.initials: CS
authors.lastname: Kee
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male