title: Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles.
abstract: Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Chunming
authors.initials: C
authors.lastname: Cai
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Singh
mesh_terms: D000578:Amidines / Q000138:chemical synthesis*; D008872:Microwaves; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000578:Amidines; D014230:Triazoles