title: Clinicopathological characteristics and outcome of adult patients with hematuria and/or proteinuria found during routine examination.
abstract: BACKGROUND
  Patients with hematuria and/or proteinuria found during routine examination are commonly encountered. To define the clinicopathological characteristics and outcome of these patients, 142 patients with definite pathological diagnosis were studied retrospectively.
  
  
  METHODS
  All the 142 patients were divided into three groups: pure hematuria (HU, n = 13), concomitant hematuria and proteinuria (HUPU, n = 79), and proteinuria alone (PU, n = 50).
  
  
  RESULTS
  At the time of renal biopsy, 26% of the patients had renal insufficiency and 48% of the patients had hypertension. Pathologically, IgA nephropathy (n = 67) was the most common. A total of 51 patients were enrolled into the follow-up group. Finally, urinary abnormalities disappeared in 18% of the patients, 22% of HU developed proteinuria, 21% of HUPU and 23% of PU appeared to have a distinct increase of proteinuria, and 15% of PU developed hematuria. Seven patients with normal blood pressure before became hypertensive and 6% of the patients with normal renal function initially developed renal insufficiency. The renal outcome was associated with proteinuria and tubulointerstitial lesions.
  
  
  CONCLUSIONS
  Because renal pathologic change does not always coincide with clinical manifestations, patients with hematuria and/or proteinuria found during routine examination do not necessarily imply a favorable outcome, so renal biopsy is quite important. Besides, early treatment and careful follow-up are helpful in these patients.
authors.affiliation: Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Peicheng
authors.initials: P
authors.lastname: Shen
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Ten
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.forename: Jianzhou
authors.initials: J
authors.lastname: Zou
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000453:epidemiology; D006417:Hematuria / Q000175:diagnosis*; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis / Q000453:epidemiology; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010808:Physical Examination; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis* / Q000628:therapy; D051437:Renal Insufficiency / Q000175:diagnosis / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D003404:Creatinine