title: Image registration and subtraction for the visualization of change in diabetic retinopathy screening.
abstract: Diabetic retinopathy (DR) is a leading cause of blindness in people of working age in developed countries. DR is characterized by lesions of the retinal microvasculature. This paper describes a technique for visualizing the changes which occur in retinal pathology over a 1 year interval. Pairs of retinal images of the same eye were acuired 12 months apart within a DR screening programme. The images were normalized, registered and subtracted to generate a contrast-enhanced difference image displaying changes in retinal appearance. The normalization factor and registration error were quantified for 104 pairs of retinal images.
authors.affiliation: Health and Rehabilitation Sciences Research Institute, University of Ulster, Shore Road, Newtownabbey BT37 0QB, Northern Ireland, UK. i.mcritchie@ulster.ac.uk
authors.forename: Ian N
authors.initials: IN
authors.lastname: McRitchie
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Hart
authors.forename: R John
authors.initials: RJ
authors.lastname: Winder
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D012189:Retrospective Studies