title: Breast cancer risk in relation to abortion: Results from the EPIC study.
abstract: The role of spontaneous and induced abortion on breast cancer risk is examined among 267,361 women recruited into the European Prospective Investigation into Cancer and nutrition between 1992 and 2000. The data were collected from 20 centers, across 9 countries, and included information on a total of 4,805 women with breast cancer, of whom 1,657 reported having ever had any type of abortion. Overall, the relative risk of breast cancer in women who reported ever having had a spontaneous abortion was not significantly elevated when compared with women who reported never having had such an abortion (RR = 1.07, 95% CI = 0.99-1.14). However, there was some evidence of a slight increase in the risk of breast cancer among women who reported having had 2 or more spontaneous abortions (1.20, 1.07-1.35). The relative risk of breast cancer among women who reported ever having had an induced abortion when compared to women who reported never having had an induced abortion was 0.95 (0.87-1.03). Overall, the findings provide further unbiased evidence of the lack of an adverse effect of induced abortion on breast cancer risk.
authors.affiliation: Cancer Research UK Epidemiology Unit, University of Oxford, United Kingdom. gill.reeves@ceu.ox.ac.uk
authors.forename: Gillian K
authors.initials: GK
authors.lastname: Reeves
authors.forename: Sau-Wan
authors.initials: SW
authors.lastname: Kan
authors.forename: Tim
authors.initials: T
authors.lastname: Key
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Xavier
authors.initials: X
authors.lastname: Paoletti
authors.forename: Franco
authors.initials: F
authors.lastname: Berrino
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Paulo
authors.initials: P
authors.lastname: Vineis
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gonzalez
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Carmen
authors.initials: C
authors.lastname: Martinez
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: José R
authors.initials: JR
authors.lastname: Quiros
authors.forename: Maria R
authors.initials: MR
authors.lastname: Tormo
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Theodora
authors.initials: T
authors.lastname: Psaltopoulou
authors.forename: Victoria
authors.initials: V
authors.lastname: Kalapothaki
authors.forename: Gabriele
authors.initials: G
authors.lastname: Nagel
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Petra H
authors.initials: PH
authors.lastname: Lahmann
authors.forename: Elisabet
authors.initials: E
authors.lastname: Wirfält
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D012307:Risk Factors; D012955:Societies, Medical