[Polymorphism of dental formula and segregation of its variants in a pedigree of kerry blue terrier dogs].
Polymorphism of the dental formula was analyzed in a sophisticated pedigree of Kerry Blue Terrier. A lack of one or more lower premolars was observed in some dogs. Two different patterns of missing teeth were identified. One pattern consisted in agenesis of a second premolar, often in combination with agenesis of neighbor teeth, including the fourth premolar. In the second pattern, agenesis of a fourth premolar was expressed as an isolated abnormality. It was shown previously that the first pattern is inherited as a recessive trait with near complete penetrance. In this work, the control of a major-gene was demonstrated for the second pattern. This abnormality develops in 70-80% of mutant homozygotes and in no more than 20% of heterozygotes and wild-type homozygotes. It was shown that the two dentition abnormalities are controlled by different genes, which were designated LPA2 and LPA4 (Lower Premolar Agenesis).
Aksenovich
T I
TI
Kulikova
A V
AV
Kniazev
S P
SP
Zorkal'tseva
I V
IV
Borodin
P M
PM
D000818:Animals; D000848:Anodontia / Q000235:genetics* / Q000662:veterinary*; D001641:Bicuspid / Q000002:abnormalities*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs / Q000002:abnormalities* / Q000033:anatomy & histology; D005796:Genes; D006579:Heterozygote; D006720:Homozygote; D009154:Mutation; D010375:Pedigree