[Current and future biochemical markers for Gaucher disease].
The biochemical markers secreted by Gaucher's cells are numerous, but none of those identified to date has offered all the expected qualities of a biomarker. Chitotriosidase and chemokine CCL18 are the most useful markers to follow enzyme replacement therapy. The identification of new biomarkers in the near future should enable a clearer understanding of the pathophysiology of this complex disease, which involves numerous cell processes.
Froissart
R
R
Laboratoire de Biochimie Pédiatrique, Hôpital Debrousse, 29, rue Sceur-Bouvier, 69322 Lyon cedex 05, France. roseline.froissart@chu-lyon.fr
D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D002403:Cathepsins / Q000097:blood; D019742:Chemokines, CC / Q000097:blood*; D002648:Child; D005293:Ferritins / Q000032:analysis*; D005500:Follow-Up Studies; D005544:Forecasting; D005776:Gaucher Disease / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000201:enzymology / Q000503:physiopathology; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011506:Proteins / Q000032:analysis*; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; C111792:CCL18 protein, human; D019742:Chemokines, CC; D011506:Proteins; C018589:lysosomal proteins; D005293:Ferritins; D006596:Hexosaminidases; C086400:chitotriosidase; D002403:Cathepsins; D007703:Peptidyl-Dipeptidase A