title: Immunoglobulin GM and KM allotypes and prevalence of anti-LKM1 autoantibodies in patients with hepatitis C virus infection.
abstract: GM and KM allotypes-genetic markers of immunoglobulin (Ig) gamma and kappa chains, respectively-are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P=0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.
authors.affiliation: Department of Internal Medicine, Alma Mater Stadiorum-University of Bologna, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Muratori
authors.forename: Susan E
authors.initials: SE
authors.lastname: Sutherland
authors.forename: Luigi
authors.initials: L
authors.lastname: Muratori
authors.forename: Alessandro
authors.initials: A
authors.lastname: Granito
authors.forename: Marcello
authors.initials: M
authors.lastname: Guidi
authors.forename: Georges
authors.initials: G
authors.lastname: Pappas
authors.forename: Marco
authors.initials: M
authors.lastname: Lenzi
authors.forename: Francesco B
authors.initials: FB
authors.lastname: Bianchi
authors.forename: Janardan P
authors.initials: JP
authors.lastname: Pandey
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis*; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000096:biosynthesis*; D007131:Immunoglobulin Km Allotypes / Q000096:biosynthesis* / Q000235:genetics; D016130:Immunophenotyping
chemical_list: D001323:Autoantibodies; D005819:Genetic Markers; D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes; C060729:anti-liver kidney microsome antibody