title: Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.
abstract: The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML-BC, but not in CML-CP. Here, no CEBPA mutation in 95 CML-BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder.
authors.affiliation: Institute of Medical Oncology, University Hospital, Berne, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pabst
authors.forename: Erica
authors.initials: E
authors.lastname: Stillner
authors.forename: Donna
authors.initials: D
authors.lastname: Neuberg
authors.forename: Stephen
authors.initials: S
authors.lastname: Nimer
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Willman
authors.forename: Alan F
authors.initials: AF
authors.lastname: List
authors.forename: Junia V
authors.initials: JV
authors.lastname: Melo
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Tenen
authors.forename: Beatrice U
authors.initials: BU
authors.lastname: Mueller
mesh_terms: D001752:Blast Crisis / Q000235:genetics*; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D045744:Cell Line, Tumor; D018450:Disease Progression; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D009154:Mutation
chemical_list: D022763:CCAAT-Enhancer-Binding Protein-alpha