title: Nutrient-regulated gene expression in eukaryotes.
abstract: The recognition of changes in environmental conditions, and the ability to adapt to these changes, is essential for the viability of cells. There are numerous well characterized systems by which the presence or absence of an individual metabolite may be recognized by a cell. However, the recognition of a metabolite is just one step in a process that often results in changes in the expression of whole sets of genes required to respond to that metabolite. In higher eukaryotes, the signalling pathway between metabolite recognition and transcriptional control can be complex. Recent evidence from the relatively simple eukaryote yeast suggests that complex signalling pathways may be circumvented through the direct interaction between individual metabolites and regulators of RNA polymerase II-mediated transcription. Biochemical and structural analyses are beginning to unravel these elegant genetic control elements.
authors.affiliation: Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Richard.Reece@manchester.ac.uk
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Reece
authors.forename: Laila
authors.initials: L
authors.lastname: Beynon
authors.forename: Stacey
authors.initials: S
authors.lastname: Holden
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Karine
authors.initials: K
authors.lastname: Rébora
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Sellick
mesh_terms: D001665:Binding Sites / Q000235:genetics; D004268:DNA-Binding Proteins; D005057:Eukaryotic Cells; D005800:Genes, Fungal; D008957:Models, Genetic; D011392:Proline / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D004268:DNA-Binding Proteins; C052130:GAL4 protein, S cerevisiae; C099289:Gal3 protein, S cerevisiae; C068399:PUT3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D011392:Proline; D012319:RNA Polymerase II