title: Method of Monte Carlo simulation verification in hadron therapy with non-tissue equivalent detectors.
abstract: In hadron therapy the spectra of secondary particles can be very broad in type and energy. The most accurate calculations of tissue equivalent (TE) absorbed dose and biological effect can be achieved using Monte Carlo (MC) simulations followed by the application of an appropriate radiobiological model. The verification of MC simulations is therefore an important quality assurance (QA) issue in dose planning. We propose a method of verification for MC dose calculations based on measurements of either the integral absorbed dose or the spectra of deposited energies from single secondary particles in non-TE material detectors embedded in a target of interest (phantom). This method was tested in boron neutron capture therapy and fast neutron therapy beams.
authors.affiliation: Centre for Medical Radiation Physics, University of Wollongong, Wollongong NSW 2522, Australia. anatoly@uow.edu.au
authors.forename: Anatoly
authors.initials: A
authors.lastname: Rosenfeld
authors.forename: Andrew
authors.initials: A
authors.lastname: Wroe
authors.forename: Martin
authors.initials: M
authors.lastname: Carolan
authors.forename: Iwan
authors.initials: I
authors.lastname: Cornelius
mesh_terms: D000465:Algorithms; D032701:Biomimetics / Q000295:instrumentation* / Q000379:methods; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D009010:Monte Carlo Method; D009502:Neutrons / Q000627:therapeutic use*; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation*