Are women who are treated for hypothyroidism at risk for pregnancy complications?
OBJECTIVE
The purpose of this study was to investigate the outcomes that are associated with pregnancy and treated hypothyroidism.


METHODS
This was a retrospective cohort study of all women who received prenatal care and were delivered at the University of California, San Francisco, between 1989 and 2001. All patients with hypothyroidism diagnosed before pregnancy or early in pregnancy were identified. Maternal, fetal, and obstetric outcomes were then collected and analyzed for women with hypothyroidism and compared with women without hypothyroidism.


RESULTS
Among 20,499 deliveries, there were 419 women (2.1%) who were treated for hypothyroidism during the study period. Hypothyroidism was more common among women > or =35 years old, white women, and women without Medicaid insurance. Treated hypothyroidism was not associated with any increase in maternal, fetal, or neonatal complications. In addition, hypothyroidism did not affect mode of delivery.


CONCLUSIONS
Compared with patients without hypothyroidism, patients with treated hypothyroidism are not at any increased risk for perinatal morbidity.
Tan
Tina O
TO
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA. tant@obgyn.ucsf.edu
Cheng
Yvonne W
YW
Caughey
Aaron B
AB
D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment