title: Comparison of elicitation potential of chloroatranol and atranol--2 allergens in oak moss absolute.
abstract: Chloroatranol and atranol are degradation products of chloroatranorin and atranorin, respectively, and have recently been identified as important contact allergens in the natural fragrance extract, oak moss absolute. Oak moss absolute is widely used in perfumery and is the cause of many cases of fragrance allergic contact dermatitis. Chloroatranol elicits reactions at very low levels of exposure. In oak moss absolute, chloroatranol and atranol are present together and both may contribute to the allergenicity and eliciting capacity of the natural extract. In this study, 10 eczema patients with known sensitization to chloroatranol and oak moss absolute were tested simultaneously to a serial dilution of chloroatranol and atranol in ethanol, in equimolar concentrations (0.0034-1072 microM). Dose-response curves were estimated and analysed by logistic regression. The estimated difference in elicitation potency of chloroatranol relative to atranol based on testing with equimolar concentrations was 217% (95% confidence interval 116-409%). Both substances elicited reactions at very low levels of exposure. It is concluded that the differences in elicitation capacity between the 2 substances are counterbalanced by exposure being greater to atranol than to chloroatranol and that both substances contribute to the clinical problems seen in oak moss absolute-sensitized individuals.
authors.affiliation: National Allergy Research Center, Université Louis Pasteur, UMR 7123, Strasbourg, France. jedu@gentoftehosp.kbhamt.dk
authors.forename: Jeanne D
authors.initials: JD
authors.lastname: Johansen
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bernard
authors.forename: Elena
authors.initials: E
authors.lastname: Giménez-Arnau
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000485:Allergens / Q000008:administration & dosage; D001547:Benzaldehydes / Q000008:administration & dosage; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004485:Eczema / Q000150:complications; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
chemical_list: D000485:Allergens; D001547:Benzaldehydes; D004338:Drug Combinations; C493895:atranol; C487450:chloroatranol