title: Aspergillus brain abscess in a patient with acute myeloid leukaemia successfully treated with voriconazole.
abstract: Cerebral aspergillosis is associated with very high mortality in immunocompromised hosts. Conventional antifungal agents like amphotericin-B and itraconazole are almost ineffective in cerebral aspergillosis. Newer azoles have been shown to penetrate the blood, cerebrospinal fluid barrier and achieve effective fungicidal concentrations. These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole.
authors.affiliation: Department of Haematology, Sandwell and West Birmingham Hospital, Lyndon Road, West Bromwich, West Midlands B714HJ, UK. fwandroo@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Wandroo
authors.forename: P
authors.initials: P
authors.lastname: Stableforth
authors.forename: Y
authors.initials: Y
authors.lastname: Hasan
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000150:complications / Q000188:drug therapy*; D020314:Central Nervous System Fungal Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D013687:Telencephalon; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole