title: High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series.
abstract: OBJECTIVE
  We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy.
  
  
  METHODS
  Between 2001 and 2004, saturation biopsies (average of 24 cores) were performed in 161 men with persistently elevated prostate specific antigen (PSA) level (median, 9 ng/ml). All had at least two previously negative, eight-core biopsy sessions. PCa predictors on saturation biopsy were integrated within multivariate nomograms.
  
  
  RESULTS
  PCa detection was 41% (n=66 of 161). PSA density and transition zone volume were the most significant predictors of PCa on saturation biopsy. The accuracy of the nomogram with the best performance characteristics was 72%.
  
  
  CONCLUSIONS
  Saturation biopsy may be indicated in men with a persistent suspicion of PCa. High-risk individuals can be identified accurately with our nomogram.
authors.affiliation: Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Walz
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Felix K-H
authors.initials: FK
authors.lastname: Chun
authors.forename: Andreas
authors.initials: A
authors.lastname: Erbersdobler
authors.forename: Alexander
authors.initials: A
authors.lastname: Haese
authors.forename: Thomas
authors.initials: T
authors.lastname: Steuber
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Hartwig
authors.initials: H
authors.lastname: Huland
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods*; D002277:Carcinoma / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D049451:Nomograms; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000706:statistics & numerical data; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*
chemical_list: D017430:Prostate-Specific Antigen