title: [A case of AFP and PIVKA-II producing gastric carcinoma].
abstract: A 71-year-old man was admitted to our hospital with edema of the ambilateral crura and liver dysfunction. Serum levels of AFP and PIVKA-II were both abnormally high. An abdominal CT revealed many low density masses in both lobes of the liver. Endoscopic examination and gastric radiography showed a Type 1 tumor in the fornix of the stomach. Biopsy specimen showed poorly differentiated adenocarcinoma. Immunohistochemical stains demonstrated the presence of AFP and PIVKA-II in tumor cells. A diagnosis of AFP and PIVKA-II producing gastric carcinoma with liver metastasis was made and the internal use of S-1 was started. The result of treatment was determined to be partial response. However, the condition of his entire body gradually worsened and he died of hepatic insufficiency.
authors.affiliation: Department of Gastroenterology, Prefecture Esashi Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Suguru
authors.initials: S
authors.lastname: Ishii
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Akutsu
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tokuno
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okuda
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Imai
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000368:Aged; D015415:Biomarkers; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D011498:Protein Precursors / Q000096:biosynthesis*; D011516:Prothrombin / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin