title: [Expression of NF-kappaB/IkappaB signal pathway in renal tissues of hepatitis B virus-associated nephritis].
abstract: OBJECTIVE
  To investigate the expression of nuclear transcription factor-kappa B (NF-kappaB)/IkappaB in renal tissues of hepatitis B virus-associated nephritis (HBVGN) and to study its role in the pathogenesis of HBVGN.
  
  
  METHODS
  The expression of NF-kappaB p65 and IkappaB-alpha in renal tissues was examined in biopsy specimens from 42 HBVGN patients, 20 patients with primary membranous nephropathy and 5 normal subjects by immunohistochemical staining.
  
  
  RESULTS
  The NF-kappaB p65 expression in glomerular and tubular of HBVGN tissues was notably higher than that in normal control tissues (P<0.05) and in primary membranous nephropathy tissues (P<0.01). The IkappaB-alpha expression in glomerular and tubular of HBVGN tissues was lower than that in primary membranous nephropathy tissues (P<0.05).
  
  
  CONCLUSIONS
  There might be protein degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in renal tissues of HBVGN, which suggests that NF-kappaB/IkappaB signal pathway may play an important role in the pathogenesis of HBVGN.
authors.affiliation: Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Han-min
authors.initials: HM
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Ji-hong
authors.initials: JH
authors.lastname: Cui
authors.forename: Yan-fang
authors.initials: YF
authors.lastname: Liu
authors.forename: Yao-guo
authors.initials: YG
authors.lastname: Lian
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015870:Gene Expression; D050533:Glomerular Basement Membrane / Q000378:metabolism*; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000472:pathogenicity; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000378:metabolism*; D009393:Nephritis / Q000209:etiology / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction / Q000502:physiology*; D051996:Transcription Factor RelA / Q000378:metabolism*; D055815:Young Adult
chemical_list: D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D051996:Transcription Factor RelA; D000072000:NF-KappaB Inhibitor alpha