Study on the ophthalmic diseases in ICR mice and BALB/c mice.
In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.
Park
Shin Ae
SA
Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea.
Jeong
Seong Mok
SM
Yi
Na Young
NY
Kim
Min Su
MS
Jeong
Man Bok
MB
Suh
Jun Gyo
JG
Oh
Yang Seok
YS
Won
Moo Ho
MH
Nam
Tchi Chou
TC
Park
Jae Hak
JH
Seo
Kang Moon
KM
D000818:Animals; D005128:Eye Diseases / Q000453:epidemiology / Q000662:veterinary*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D012376:Rodent Diseases / Q000453:epidemiology