The effects of erythropoietin on auditory processing following neonatal hypoxic-ischemic injury.
Neonatal hypoxia-ischemia (HI) is a common cause of brain damage and subsequent behavioral deficits in premature/term infants. Rapid auditory processing deficits have been suggested to play a role in later language impairments in this population. We have previously shown auditory deficits in rats with neonatal HI injury and now report novel effects of behavioral sparing and neuroprotection following treatment with a low dose of Erythropoietin using this HI injury model.
McClure
Melissa M
MM
Department of Psychology, Behavioral Neuroscience Division, Unit 1020, 806 Babbidge Road, Storrs, CT 06069-1020, USA.
Threlkeld
Steven W
SW
Fitch
R Holly
RH
D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D004192:Discrimination, Psychological / Q000187:drug effects; D004921:Erythropoietin / Q000627:therapeutic use*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D012022:Reflex, Acoustic / Q000187:drug effects*; D013997:Time Factors
D018696:Neuroprotective Agents; D011994:Recombinant Proteins; D004921:Erythropoietin