Endemic pemphigus foliaceus in Venezuela: report of two children.
Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously associated with this disease. However, it shares a common epitope with all the human leukocyte antigen DRB1 alleles that have been involved in this disease among Brazilian populations. Although this condition is endemic in Brazil, our patients are the first two reported in Venezuela.
González
Francisco
F
Department of Dermatology, Hospital Universitario de Caracas, Luis Razetti School of Medicine, Central University of Venezuela, Caracas, Venezuela.
Sáenz
Ana Maria
AM
Cirocco
Antonietta
A
Tacaronte
Inés Maria
IM
Fajardo
Javier Enrique
JE
Calebotta
Adriana
A
D000293:Adolescent; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014687:Venezuela
D002738:Chloroquine; D011241:Prednisone