The role of botulinum toxin in postparotidectomy fistula treatment. A technical note.
OBJECTIVE
Parotid fistula is a well-known complication of parotidectomy or penetrating injury of the parotid gland. The management of parotid fistula has been controversial, and numerous conservative and surgical treatment methods have been described.


METHODS
We report 3 cases of parotid fistula after partial parotidectomy, which were treated by botulinum toxin injection under electromyographic control into the residual substance of parotid gland.


RESULTS
Complete healing of the fistula was achieved with a single botulinum toxin treatment in all patients. No side effects were observed after the treatment. The patients are disease-free after 21, 18, and 14 months, respectively.


CONCLUSIONS
In the considered cases, the localized injection of botulinum toxin into the parotid gland resulted to an effective and long-lasting treatment of postparotidectomy fistula.
Marchese-Ragona
Rosario
R
Department of Otolaryngology-Head Neck Surgery, University of Padua, Padua, Italy. rmr@unipd.it
Marioni
Gino
G
Restivo
Domenico A
DA
Staffieri
Alberto
A
D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000188:drug therapy* / Q000209:etiology; D010307:Parotid Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy*; D012467:Salivary Gland Fistula / Q000188:drug therapy* / Q000209:etiology
D019274:Botulinum Toxins, Type A