Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.
7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
Rathore
Bhawani Singh
BS
Department of Chemistry, University of Rajasthan, Jaipur, India. bhawani_bog@yahoo.com
Kumar
M
M
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D001407:Bacillus / Q000187:drug effects*; D003500:Cyclization; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects*; D004952:Esters / Q000737:chemistry; D005464:Fluorobenzenes / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013843:Thiazines / Q000138:chemical synthesis / Q000494:pharmacology*
D000890:Anti-Infective Agents; D004952:Esters; D005464:Fluorobenzenes; D007659:Ketones; D010636:Phenols; D013438:Sulfhydryl Compounds; D013843:Thiazines; C044697:benzotrifluoride; C042983:thiophenol; D004121:Dimethyl Sulfoxide