title: Inflammatory bowel disease.
abstract: Twenty five per cent of inflammatory bowel disease presents in childhood. Growth and nutrition are key issues in the management with the aim of treatment being to induce and then maintain disease remission with minimal side effects. Only 25% of Crohn's disease presents with the classic triad of abdominal pain, weight loss, and diarrhoea. Most children with ulcerative colitis have blood in the stool at presentation. Inflammatory markers are usually although not invariably raised at presentation (particularly in Crohn's disease). Full investigation includes upper gastrointestinal endoscopy and ileocolonoscopy. Treatment requires multidisciplinary input as part of a clinical network led by a paediatrician with special expertise in the management of the condition.
authors.affiliation: Paediatric Medical Unit, Southampton General Hospital, Southampton, UK. mark.beattie@suht.swest.nhs.uk
authors.forename: R M
authors.initials: RM
authors.lastname: Beattie
authors.forename: N M
authors.initials: NM
authors.lastname: Croft
authors.forename: J M
authors.initials: JM
authors.lastname: Fell
authors.forename: N A
authors.initials: NA
authors.lastname: Afzal
authors.forename: R B
authors.initials: RB
authors.lastname: Heuschkel
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents