Modification of histogenetic processes in rat nervous tissue after administration of dexamethasone during prenatal development.
Experiments on rats using confocal microscopy and immunocytochemistry showed that single doses of the synthetic corticosteroid hormone dexamethasone to pregnant females during the period of elevated sensitivity of the developing fetal nervous system (day 13 of intrauterine development) led to modification of histogenetic processes in the brain, reflected as changes in its structural-functional characteristics during postnatal ontogenesis.
Korzhevskii
D E
DE
Department of Morphology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Gilerovich
E G
EG
Khozhai
L I
LI
Grigor'ev
I P
IP
Otellin
V A
VA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D003423:Critical Period, Psychological; D003907:Dexamethasone / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D013315:Stress, Psychological / Q000378:metabolism*
D005938:Glucocorticoids; D003907:Dexamethasone