title: Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy.
abstract: Heparin is the drug of choice for the treatment or the prevention of thromboembolic disease during pregnancy. However, treatment options are limited when heparin cannot be used because of hypersensitivity skin reactions. Despite the recent availability of new anticoagulant agents, data relating to their use during pregnancy are lacking. This report describes the successful management with fondaparinux, during 150 days, of a pregnant patient with protein S deficiency and prior deep vein thrombosis (DVT) who developed heparin and danaparoid hypersensitivity.
authors.affiliation: Service of Vascular Medicine, University Hospital of Lausanne (CHUV), Av Pierre Decker 5, 1011 Lausanne, Switerland. lucia.mazzolai@chuv.ch
authors.forename: Lucia
authors.initials: L
authors.lastname: Mazzolai
authors.forename: Patrick
authors.initials: P
authors.lastname: Hohlfeld
authors.forename: Francois
authors.initials: F
authors.lastname: Spertini
authors.forename: Daniel
authors.initials: D
authors.lastname: Hayoz
authors.forename: Marc
authors.initials: M
authors.lastname: Schapira
authors.forename: Michel A
authors.initials: MA
authors.lastname: Duchosal
mesh_terms: D000328:Adult; D005260:Female; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D011134:Polysaccharides / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D018455:Protein S Deficiency / Q000188:drug therapy / Q000235:genetics; D013923:Thromboembolism / Q000235:genetics
chemical_list: D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux