title: Controlled-release microchips.
abstract: Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.
authors.affiliation: Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Sharma
authors.forename: A Jasper
authors.initials: AJ
authors.lastname: Nijdam
authors.forename: Piyush M
authors.initials: PM
authors.lastname: Sinha
authors.forename: Robbie J
authors.initials: RJ
authors.lastname: Walczak
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liu
authors.forename: Mark M-C
authors.initials: MM
authors.lastname: Cheng
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry; D012825:Silicon / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D012825:Silicon