title: Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis.
abstract: Deubiquitination of monoubiquitinated proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cysteine proteases in eukaryotic cells. Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation.
authors.affiliation: Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Errol C
authors.initials: EC
authors.lastname: Friedberg
mesh_terms: D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage; D004260:DNA Repair; D010450:Endopeptidases / Q000378:metabolism; D005786:Gene Expression Regulation; D008954:Models, Biological; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D064570:Ubiquitin-Specific Proteases; D014466:Ultraviolet Rays
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D025801:Ubiquitin; D004247:DNA; D010450:Endopeptidases; D064570:Ubiquitin-Specific Proteases