title: [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors].
abstract: BACKGROUND
  To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.
  
  
  METHODS
  The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).
  
  
  RESULTS
  The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.
  
  
  CONCLUSIONS
  Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.
authors.affiliation: AIDS Research Center, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Shu-xiang
authors.initials: SX
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
authors.forename: Xiao-xu
authors.initials: XX
authors.lastname: Han
authors.forename: Zi-ning
authors.initials: ZN
authors.lastname: Zhang
authors.forename: Ya-nan
authors.initials: YN
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Yong-jun
authors.initials: YJ
authors.lastname: Jiang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Su
mesh_terms: D054377:Chemokine CXCL12 / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D054390:Receptors, CCR2 / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics; D015728:Receptors, HIV / Q000235:genetics*
chemical_list: D054377:Chemokine CXCL12; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D015728:Receptors, HIV