title: Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
abstract: Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.
authors.affiliation: Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. a.chris.krueger@abbot.com
authors.forename: A Chris
authors.initials: AC
authors.lastname: Krueger
authors.forename: Darold L
authors.initials: DL
authors.lastname: Madigan
authors.forename: Wen W
authors.initials: WW
authors.lastname: Jiang
authors.forename: Warren M
authors.initials: WM
authors.lastname: Kati
authors.forename: Dachun
authors.initials: D
authors.lastname: Liu
authors.forename: Yaya
authors.initials: Y
authors.lastname: Liu
authors.forename: Clarence J
authors.initials: CJ
authors.lastname: Maring
authors.forename: Sherie
authors.initials: S
authors.lastname: Masse
authors.forename: Keith F
authors.initials: KF
authors.lastname: McDaniel
authors.forename: Tim
authors.initials: T
authors.lastname: Middleton
authors.forename: Hongmei
authors.initials: H
authors.lastname: Mo
authors.forename: Akhteruzzaman
authors.initials: A
authors.lastname: Molla
authors.forename: Debra
authors.initials: D
authors.lastname: Montgomery
authors.forename: John K
authors.initials: JK
authors.lastname: Pratt
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rockway
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Kempf
mesh_terms: D001581:Benzothiadiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase
chemical_list: D001581:Benzothiadiazines; D004791:Enzyme Inhibitors; D013449:Sulfonamides; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase