title: Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.
abstract: Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of gamma-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein gamma-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K1 suppressed inflammation in the rat.
authors.affiliation: Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University , Sendai, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hiwatashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Mizutani
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002460:Cell Line; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015850:Interleukin-6 / Q000235:genetics; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D014812:Vitamin K / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D014812:Vitamin K