Antimicrobial susceptibility pattern of Clostridium difficile and its relation to PCR ribotypes in a Swedish university hospital.
All 238 Clostridium difficile isolates were susceptible to metronidazole and vancomycin, whereas 84% and 1% were resistant to clindamycin and fusidic acid. Etest MICs for metronidazole were lower than agar dilution MICs (P < 0.01) but without difference in susceptible-intermediate-resistant categorization. No particular PCR ribotype was associated with clindamycin or fusidic acid resistance.
Aspevall
Olle
O
Department of Clinical Microbiology, Akademiska University Hospital, SE-751 85 Uppsala, Sweden. olov.aspevall@akademiska.se
Lundberg
Annika
A
Burman
Lars G
LG
Akerlund
Thomas
T
Svenungsson
Bo
B
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial; D005672:Fusidic Acid / Q000494:pharmacology*; D006785:Hospitals, University; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D021521:Ribotyping; D012703:Serotyping; D013548:Sweden / Q000453:epidemiology; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002981:Clindamycin; D005672:Fusidic Acid; D014640:Vancomycin