title: Canine limbal melanoma: 30 cases (1992-2004). Part 2. Treatment with lamellar resection and adjunctive strontium-90beta plesiotherapy--efficacy and morbidity.
abstract: OBJECTIVE
  To evaluate the efficacy of lamellar resection and adjunctive 90Sr-beta plesiotherapy in the management of canine limbal melanoma and the frequency and morbidity of early and late-onset side effects following treatment.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Thirty dogs treated for limbal melanoma at the Animal Health Trust (AHT), between 1992 and 2004.
  
  
  METHODS
  Medical records were reviewed and information collected on the radiation dose administered, duration of follow-up, and the frequency of early- and late-onset ocular side effects. Follow-up information was obtained by re-examination of patients or completion of a telephone interview with the referring veterinary surgeons or the owners.
  
  
  RESULTS
  Recurrence of limbal melanoma occurred in 1 of 30 cases (3%; 95% CI: 0.2-14%). One or more side effects occurred in 16 of 30 cases (53%; 95% CI: 28.1-74.9). The occurrence of side effects was not associated with the number of sites treated or the total surface dose of radiation. Short-term side effects were reported in 16/30 cases (53%) and included corneal scarring (12/30), corneal neovascularization (6/30), conjunctivitis with or without granulation tissue formation (5/30), lipid keratopathy (1/30), and localized bullous keratopathy (2/30). Long-term side effects were reported in 6 of 30 cases (20%) cases and included deep scleral thinning (5/30), focal scleromalacia (3/30), globe perforation (2/30), lipid keratopathy (3/30), localized bullous keratopathy (1/30), and sectoral cortical cataract (1/30).
  
  
  CONCLUSIONS
  Lamellar resection and adjunctive 90Sr-beta plesiotherapy is relatively easy to perform, is minimally invasive, and extremely well tolerated by patients. The treatment is highly efficacious in the management of canine limbal melanoma. Modification of the radiation dosimetry, in particular reducing the total dose of radiation and the dose per radiation fraction, is necessary to reduce the incidence of late onset side effects.
authors.affiliation: Comparative Ophthalmology Unit, Center for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford CB8 7UU, UK. david.donaldson@aht.org.uk
authors.forename: David
authors.initials: D
authors.lastname: Donaldson
authors.forename: Jane
authors.initials: J
authors.lastname: Sansom
authors.forename: Vicky
authors.initials: V
authors.lastname: Adams
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005134:Eye Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D016850:Limbus Corneae; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000662:veterinary; D013326:Strontium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013326:Strontium Radioisotopes