title: Positive pressure ventilation treatment reduces plasma levels of amino terminal-pro brain natriuretic peptide in congestive heart failure patients with sleep apnea.
abstract: BACKGROUND
  The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA).
  
  
  RESULTS
  Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased.
  
  
  CONCLUSIONS
  Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA.
authors.affiliation: Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, PR China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zhao
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Luo
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Xiong
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Ni
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Yue-Jin
authors.initials: YJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000628:therapy*; D014691:Ventilation / Q000592:standards*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain