Motoneuron injury and repair: New perspectives on gonadal steroids as neurotherapeutics.
In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.
Tetzlaff
Julie E
JE
Department of Cell Biology, Neurobiology, and Anatomy, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
Huppenbauer
Christopher B
CB
Tanzer
Lisa
L
Alexander
Thomas D
TD
Jones
Kathryn J
KJ
D000818:Animals; D019771:Axotomy; D002470:Cell Survival; D002478:Cells, Cultured; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005154:Facial Nerve / Q000473:pathology / Q000502:physiology; D058851:GPI-Linked Proteins; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006358:Hot Temperature; D008565:Membrane Proteins / Q000378:metabolism; D009046:Motor Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D055532:SMN Complex Proteins
D017362:Cyclic AMP Response Element-Binding Protein; D058851:GPI-Linked Proteins; D012739:Gonadal Steroid Hormones; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; C484377:Nrn1 protein, mouse; D016601:RNA-Binding Proteins; D055532:SMN Complex Proteins