title: Abnormal gastroesophageal flap valve is highly associated with gastroesophageal reflux disease among subjects undergoing routine endoscopy in Taiwan.
abstract: OBJECTIVE
  Gastroesophageal flap valve (GEFV) grade predicts severe gastroesophageal reflux disease in Caucasians, but its role in other populations is unclear. This study evaluated the significance of endoscopic grading of the GEFV in Taiwanese subjects.
  
  
  METHODS
  Five hundred and six consecutive patients undergoing routine check-ups at the National Taiwan University Hospital were enrolled. Symptoms of upper gastrointestinal disease and endoscopic severity of esophageal mucosal injury were correlated to GEFV grades according to the Hill classification.
  
  
  RESULTS
  The frequency of abnormal valves (Hill grades III or IV) was 27.3%. Of these, 42.7% had erosive esophagitis (EE). The majority of patients with EE were classified as Los Angeles grades A and B (79.7 and 16.9%, respectively). The prevalence of EE, hiatal hernia and, to a lesser degree, non-erosive reflux disease, increased with altered GEFV. Patients with abnormal valves were younger and more likely to be male, overweight, and to have atypical and extraesophageal symptoms.
  
  
  CONCLUSIONS
  Taiwanese patients with abnormal GEFVs share similar characteristics and risk factors with the patients who have EE. Endoscopic grading of the GEFV is highly associated with GERD, and in particular EE, in subjects undergoing routine endoscopy.
authors.affiliation: Division of Endoscopy, Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors.forename: Bor-Ru
authors.initials: BR
authors.lastname: Lin
authors.forename: Jau-Min
authors.initials: JM
authors.lastname: Wong
authors.forename: Mei-Chi
authors.initials: MC
authors.lastname: Chang
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Liao
authors.forename: Pei-Ming
authors.initials: PM
authors.lastname: Yang
authors.forename: Jiiang-Huei
authors.initials: JH
authors.lastname: Jeng
authors.forename: Wan-Ru
authors.initials: WR
authors.lastname: Liao
authors.forename: Teh-Hong
authors.initials: TH
authors.lastname: Wang
mesh_terms: D004941:Esophagitis / Q000453:epidemiology / Q000503:physiopathology; D004943:Esophagogastric Junction / Q000503:physiopathology*; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology