Neuroprotective bibenzyl glycosides of Stemona tuberosa roots.
Three new bibenzyl glycosides characterized as stilbostemin B 3'-beta-D-glucopyranoside (1), stilbostemin H 3'-beta-D-glucopyranoside (2), and stilbostemin I 2"-beta-D-glucopyranoside (3) were isolated from the roots of Stemona tuberosa. All three bibenzyl glycosides significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
Lee
Ki Yong
KY
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.
Sung
Sang Hyun
SH
Kim
Young Choong
YC
D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020258:Neurotoxicity Syndromes; D016627:Oxidopamine / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D001632:Bibenzyls; D006027:Glycosides; D018696:Neuroprotective Agents; C511031:stilbostemin B 3'-beta-D-glucopyranoside; C511032:stilbostemin H 3'-beta-D-glucopyranoside; D016627:Oxidopamine