title: Marginal zone B-cell lymphoma of minor salivary gland representing tumor-forming amyloidosis of the oral cavity. A case report.
abstract: We report here a case of mucosa-associated lymphoid tissue (MALT)-type lymphoma arising from the minor salivary gland of the oral cavity exhibiting tumor-forming amyloidosis. The patient was a 64-year-old Japanese woman who presented with 4-year history of a left soft palate mass. Despite multiple and multifocal recurrences including the lip, soft palate, tongue, oral base and vocal code and soft palate, the tumor remained localized in the upper aerodigestive tract, and the patient did not develop multiple myeloma during the course of disease. Histologically, the majority of the lesion was occupied by amyloid deposition. Only the periphery of the lesion contained numerous plasmacytoid cells, along with occasional centrocyte-like cells. In addition, lymphoepithelial lesion and follicular colonization were noted. The present case indicates that primary minor salivary gland MALT-type lymphoma appears to be the cause of tumor-forming amyloidosis of the upper aerodigestive tract including the larynx.
authors.affiliation: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Shiro
authors.initials: S
authors.lastname: Sugihara
authors.forename: Misa
authors.initials: M
authors.lastname: Iijima
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ono
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
mesh_terms: D000686:Amyloidosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D010160:Palate, Soft / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000150:complications* / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology*