Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.
Krueger
A Chris
AC
Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. a.chris.krueger@abbot.com
Madigan
Darold L
DL
Jiang
Wen W
WW
Kati
Warren M
WM
Liu
Dachun
D
Liu
Yaya
Y
Maring
Clarence J
CJ
Masse
Sherie
S
McDaniel
Keith F
KF
Middleton
Tim
T
Mo
Hongmei
H
Molla
Akhteruzzaman
A
Montgomery
Debra
D
Pratt
John K
JK
Rockway
Todd W
TW
Zhang
Rong
R
Kempf
Dale J
DJ
D001581:Benzothiadiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase
D001581:Benzothiadiazines; D004791:Enzyme Inhibitors; D013449:Sulfonamides; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase