Apoptotic changes of Middle East jaw lymphoma.
Jaw lymphoma a highly malignant tumor affects children between two and eight years, duration of illness between two and three weeks, and the general condition of severe toxicity, and the death rate is 91.9%. The aim of this cellular study is to show the apoptotic changes associated with these tumors. Twenty-four children, 13 boys and 11 girls, were reported with jaw lymphoma and studied for apoptotic detection of the tumor through morphological assessment by using ground section and electron microscopy. Ground section shows lymphoblastic lymphoma, darkly-stained of ribonucleic acid, also apoptotic changes seen in some of the cells. Electron microscopy showed high mitotic figures, lymphoblast transformed to plasma cell, high nucleocytoplasmic ratio, some cells showed double nuclei, some nuclei are crested in shape or convoluted, degenerative changes seen in some of the cells, chromatin clumps near the nuclear membrane, mitochondria showing homogenous and degenerative changes, virus like particles seen in this nucleus and cytoplasm. The presence of low-level of apoptosis is a poor prognostic feature of jaw lymphoma due to homogeneity and degenerative changes of the mitochondria and disruption of the cell surface.
Kummoona
Raja
R
Iraqi Board of Medical Specializations, Medical Avenue-America 38/2/887, PO Box 65066, Baghdad, Iraq. dr_raja_kummoona@yahoo.com
Maky
Aliaa
A
D017209:Apoptosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008877:Middle East; D010784:Photomicrography; D016613:Plastic Embedding; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D011379:Prognosis