Coexistence of light chain disease and chronic lymphocytic leukaemia, a complex karyotype with a rapid fatal outcome.
We report on a 48-year-old man with concomitantly diagnosed kappa expressing chronic lymphocytic leukaemia (CLL) and lambda light chain disease with highly complex chromosomal aberrations. The clinical course of the disease was very aggressive with survival of only 1 month. We demonstrate the distinct clonal origin by cytogenetic data and immunoglobulin rearrangement studies. To our knowledge this is the first report of a light chain disease associated with CLL.
Castryck
H
H
Laboratory of Clinical Biology, Imelda Hospital, Bonheiden, Belgium. heidi.castryck@student.kuleuven.ac.be
van den Driessche
M
M
Hagemeijer
A
A
Stul
M
M
Wynendaele
W
W
Vandenberghe
P
P
Moerman
J
J
D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D017809:Fatal Outcome; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000235:genetics; D007147:Immunoglobulin Light Chains; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged
D007147:Immunoglobulin Light Chains