title: Preventive and therapeutic effects of alpha-acid glycoprotein in mice infected with B. anthracis.
abstract: We studied the effects of alpha1-acid glycoprotein preparations on the survival rate of BALB/c mice infected with the lethal dose of B. anthracis STI-1. Apart from native alpha1-acid glycoprotein from donor blood, we studied 3 glycoforms differing in the affinity for concanavalin A and structure of carbohydrate chains. The protective effect of alpha1-acid glycoprotein preparations did not depend on its dose and was observed 3 months after treatment (0.3 mg per mouse). The protective effect was revealed in mice receiving alpha1-acid glycoprotein preparations 2 h before infection and 24 h after inoculation of the bacterial culture. In the latter case the survival rate of animals was much higher compared to that observed in preventive administration of alpha1-acid glycoprotein. The protective effect practically did not depend on the time of treatment with glycoforms. Pretreatment with alpha1-acid glycoprotein preparations significantly decreased plasma interferon-gamma concentration. Administration of the test preparations 24 h after infection decreased the concentration of tumor necrosis factor-alpha.
authors: State Research Center of Applied Microbiology, Obolensk, Moscow.
authors: I G
authors: IG
authors: Shemyakin
authors: A L
authors: AL
authors: Pukhalsky
authors: V N
authors: VN
authors: Stepanshina
authors: G V
authors: GV
authors: Shmarina
authors: V A
authors: VA
authors: Aleshkin
authors: S S
authors: SS
authors: Afanas'ev