title: Second malignant neoplasia in early (TIS-T1) glottic carcinoma.
abstract: BACKGROUND
  We performed a population-based study to determine the incidence and patterns of second malignant neoplasia (SMN) in early glottic carcinoma.
  
  
  METHODS
  All patients diagnosed with Tis-T1 glottic carcinoma in the southwest of the Netherlands between 1982 and 1993 (359) were included. Sources of the data were patient charts and the regional cancer registry.
  
  
  RESULTS
  SMN incidence was 27.7% (median follow-up, 89 months). Observed-to-expected ratios were increased for lung, bladder, urinary tract, pancreatic, colorectal, and head and neck cancers. The incidence of head and neck and esophageal cancer was surprisingly low.
  
  
  CONCLUSIONS
  Patients with early glottic carcinoma are at a reliably increased risk of the development of tumors not only in the areas of the upper aerodigestive tract, but also in the bladder, pancreas, and colorectum. The low incidence of head and neck and esophageal tumors does not appear to support routine panendoscopy in this patient population.
authors: Department of ENT, Head and Neck Surgery H4-Q, Leiden University Medical Center, Albinusdreef 2, Postbus 9600, 2300 RC Leiden, The Netherlands. evsjogren@lumc.nl
authors: Elisabeth V
authors: EV
authors: Sjögren
authors: Simone
authors: S
authors: Snijder
authors: Joost
authors: J
authors: van Beekum
authors: Robert Jan
authors: RJ
authors: Baatenburg de Jong