title: One-flask synthesis of dinucleoside tetra- and pentaphosphates.
abstract: [reaction: see text] We report a one-flask route for the synthesis of dinucleoside tetra- and pentaphosphates, in isolated yields of 50-85%. This route relies on a mixture of P(III) and P(V) chemistries, using phosphitylation of a protected nucleoside with 2-chloro-4H-l,3,2-benzo-dioxaphosphorin-4-one (salicylchlorophosphite), followed by sequential reaction with inorganic pyrophosphate and a nucleoside 5' mono- or diphosphate.
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA.
authors: Qianwei
authors: Q
authors: Han
authors: Barbara L
authors: BL
authors: Gaffney
authors: Roger A
authors: RA
authors: Jones