title: [Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation].
abstract: OBJECTIVE
  To search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity.
  
  
  METHODS
  According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.
  
  
  RESULTS
  Four new compounds were obtained and confirmed by spectra.
  
  
  CONCLUSIONS
  Lipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.
authors: West China School of Pharmacy, Sichuan University, Chengdu 610041, China. denglan234@sina.com
authors: Lan
authors: L
authors: Deng
authors: Heng
authors: H
authors: Huang
authors: Ming-xia
authors: MX
authors: Xu