Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity.
Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level.
Badoual
Mathilde
M
Integrative and Computational Neuroscience Unit (UNIC), CNRS, Gif-sur-Yvette, France.
Zou
Quan
Q
Davison
Andrew P
AP
Rudolph
Michael
M
Bal
Thierry
T
Frégnac
Yves
Y
Destexhe
Alain
A