title: Biomimetic approach to perophoramidine and communesin via an intramolecular cyclopropanation reaction.
abstract: [reaction: see text] Starting from tryptamine 4 and isatin 5, a biomimetic approach to the pentacyclic substructure 1 of perophoramidine and communesin was developed. The key steps were to create a stable three/six bicyclic system 2 on the 2,3-double bond of an indole derivative 3 by an intramolecular cyclopropanation, followed by ring opening of the resulting cyclopropane ring with the in situ generated amine group of an aniline.
authors: Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu, PRC.
authors: Jun
authors: J
authors: Yang
authors: Hao
authors: H
authors: Song
authors: Xue
authors: X
authors: Xiao
authors: Jue
authors: J
authors: Wang
authors: Yong
authors: Y
authors: Qin