Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma.
OBJECTIVE
The aim of this study was to evaluate the expression of cyclooxygenase-2 in human breast cancer using immunohistochemistry and to determine whether the expression of cyclooxygenase-2 is associated with clinicopathological factors in invasive ductal breast carcinoma.


METHODS
Cyclooxygenase-2 expression was investigated by immunohistochemistry in 30 invasive ductal breast carcinoma specimens and relationships between cyclooxygenase-2 expression and age, histological grade, histological type, nodal status, and hormone receptor status were evaluated.


RESULTS
Cyclooxygenase-2 expression was found in 56.7% of the tumor samples and was related to histological grade (P<0.01) and histological type (P<0.001).


CONCLUSIONS
Our results suggest that cyclooxygenase-2 expression has an important role in tumor differentiation in invasive ductal breast carcinoma.
Takeshita
Emiko
E
Department of Surgical Oncology, Graduate School of Medicine, Tokyo Medical and Dental University 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Osanai
Takayuki
T
Higuchi
Tetsuro
T
Soumaoro
Labile Togba
LT
Sugihara
Kenichi
K