An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones.
5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.
Mitchell
Claire E T
CE
Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK CB2 1EW.
Brenner
Stacey E
SE
García-Fortanet
Jorge
J
Ley
Steven V
SV