Treatment of Japanese restless legs syndrome patients with cabergoline: an open clinical preliminary trial.
OBJECTIVE
To determine the effective dose of cabergoline in Japanese patients with restless legs syndrome (RLS).


METHODS
Six cases of idiopathic RLS and three of RLS with Parkinson disease (PD) participated in an open clinical preliminary trial. All cases were diagnosed based on the clinical criteria of the International RLS Study Group. Three RLS cases (1.3%) were detected out of 229 consecutive cases with PD. RLS severity was evaluated with International RLS Study Group (IRLSSG) Rating Scale Version 2.2 before and one year after the treatment with cabergoline.


RESULTS
For 6 idiopathic RLS patients, the IRLSSG questionnaire scores improved from 25.5+/-3.7 to 10.7+/-8.9 (p=0.028, Wilcoxon test) with 1 mg of daily cabergoline at the endpoint. For 3 RLS cases with PD, the score was 21.7+/-3.7 before the treatment, and RLS symptoms completely disappeared with 1 mg of cabergoline. One of RLS cases with PD required additional cabergoline later because of parkinsonism. No adverse event with cabergoline was reported in this study.


CONCLUSIONS
One mg of daily cabergoline is effective in some Japanese patients of RLS.
Aizawa
Hitoshi
H
First Department of Medicine, Asahikawa Medical College, Asahikawa.
Aburakawa
Yoko
Y
Suzuki
Yasuhiro
Y
Enomoto
Hiroyuki
H
Makita
Yoshihiro
Y
Kikuchi
Kenjiro
K
Kimura
Takashi
T
Yahara
Osamu
O