Simple protocol for NMR analysis of the enantiomeric purity of diols.
[reaction: see text] A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral 1,2-, 1,3-, and 1,4-diols by (1)H NMR spectroscopic analysis is described. The method involves treatment with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine to afford a mixture of diastereoisomeric iminoboronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diol.
Kelly
Andrew M
AM
Department of Chemistry, University of Bath, UK.
Pérez-Fuertes
Yolanda
Y
Arimori
Susumu
S
Bull
Steven D
SD
James
Tony D
TD