A dedicated Wnt secretion factor.
The Wnt family of signaling proteins mediates cell-cell communication during development. In this issue of Cell, Bänziger et al. (2006) and Bartscherer et al. (2006) identify Wntless/Evi, a multipass transmembrane protein in the secretory pathway of Wnt-producing cells that promotes Wnt secretion.
Ching
Wendy
W
Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Beckman Center, B271, Stanford, CA 94305, USA.
Nusse
Roel
R