title: Diabetic dyslipidaemia.
abstract: OBJECTIVE
  Diabetic dyslipidaemia is a cluster of plasma lipid and lipoprotein abnormalities that are metabolically interrelated. The increase of large type 1 very low density lipoprotein particles in type 2 diabetes initiates a sequence of events that generates atherogenic remnants, small dense low-density lipoprotein and small dense high-density lipoprotein particles. Thus, it is of great importance to elucidate the mechanisms behind the overproduction of large very low density lipoprotein particles in diabetic dyslipidaemia. This review discusses the pathophysiology of very low density lipoprotein metabolism in type 2 diabetes and recent concepts of lipid management of diabetic dyslipidaemia.
  
  
  RESULTS
  Results indicate that triglyceride and apolipoprotein B production in types 1 and 2 very low density lipoprotein are significantly correlated, suggesting a coupling of the two processes governing the metabolism of these lipoprotein subpopulations. Insulin resistance, hyperglycaemia, and liver fat were associated with excess hepatic production of type 1 but not type 2 very low density lipoprotein particles. These data provide support for the independent regulation of types 1 and 2 very low density lipoprotein apolipoprotein B production.
  
  
  CONCLUSIONS
  Recent data suggest that the assembly of very low density lipoprotein is fundamentally altered in type 2 diabetes, explaining the overproduction of large type 1 very low density lipoprotein as well as the inability of insulin to suppress production of type 1 very low density lipoprotein in type 2 diabetes. Future discoveries hopefully will delineate the regulatory steps to allow more targeted treatment of diabetic dyslipidaemia.
authors: Sahlgrenska Center for Metabolism and Cardiovascular Research, Wallenberg Laboratory for Cardiovascular Research and the Department of Metabolism and Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
authors: Martin
authors: M
authors: Adiels
authors: Sven-Olof
authors: SO
authors: Olofsson
authors: Marja-Riitta
authors: MR
authors: Taskinen
authors: Jan
authors: J
authors: Borén