title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
abstract: Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.
authors: Beijing Institute of Biotechnology, Beijing 100850, China.
authors: Xuan
authors: X
authors: Liu
authors: Wei
authors: W
authors: Huang
authors: Chufang
authors: C
authors: Li
authors: Ping
authors: P
authors: Li
authors: Jing
authors: J
authors: Yuan
authors: Xiaorong
authors: X
authors: Li
authors: Xiao-Bo
authors: XB
authors: Qiu
authors: Qingjun
authors: Q
authors: Ma
authors: Cheng
authors: C
authors: Cao