title: Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity.
abstract: We investigated the role of p53 in nuclear factor (NF)-kappaB dependent, platelet-activating factor (PAF)-induced vascular endothelial growth factor (VEGF) expression. Transfected NF-kappaB subunits in ECV304 cells increased the tumor necrosis factor-alpha promoter activity, which was completely inhibited by p53. Transfected p53 increased p53RE promoter activity, which was completely inhibited by NF-kappaB subunits, indicating that cross-regulation occurs between NF-kappaB and p53. PAF-induced increase in VEGF expression was correlated with decreased p53 activity. These data suggest that NF-kappaB-dependency of the PAF-induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-kappaB activity.
authors: Department of Biological Sciences, The Institute of Basic Sciences, Chonnam National University, Kwangju 500-757, Republic of Korea.
authors: Hyun-Mi
authors: HM
authors: Ko
authors: Hae Hyun
authors: HH
authors: Jung
authors: Kook Heon
authors: KH
authors: Seo
authors: Yeong-Rim
authors: YR
authors: Kang
authors: Han-A
authors: HA
authors: Kim
authors: Sung Jun
authors: SJ
authors: Park
authors: Hern-Ku
authors: HK
authors: Lee
authors: Suhn-Young
authors: SY
authors: Im