title: Responses of dorsal spinal cord blood flow to innocuous cutaneous stimulation in anesthetized rats.
abstract: In urethane-anesthetized, artificially-ventilated rats, alterations in dorsal spinal cord blood flow (SCBF) were measured with a laser Doppler flowmeter in response to innocuous mechanical cutaneous stimulation. SCBF recorded at the T12-L1 level increased with brushing of the ipsilateral, but not contralateral, upper back, lower back or proximal hindlimb. Brushing of the forepaw, proximal forelimb or hindpaw had no effect on T12-L1 SCBF. SCBF recorded at the L4-6 level increased with brushing of the ipsilateral, but not contralateral, proximal hindlimb and hindpaw. Brushing of the forepaw, proximal forelimb, upper back or lower back had no effect on SCBF at the L4-6 level. None of these brushing stimuli produced significant changes in systemic arterial blood pressure or heart rate. Pretreatment with phenoxybenzamine, an alpha adrenoceptor blocking agent, resulted in a small but statistically significant attenuation in the response of SCBF to brushing. However, pretreatment with propranolol, a beta adrenoceptor blocking agent, or atropine, a muscarinic cholinergic receptor blocking agent, produced no such effect. These results indicate that innocuous mechanical cutaneous input can produce a segmentally-organized increase in regional SCBF, which may be mediated in part, by alpha adrenergic receptors.
authors: Center for Medical Science, International University of Health and Welfare, Otawara, Tochigi 324-8501, Japan. mieko-ku@iuhw.ac.jp
authors: Mieko
authors: M
authors: Kurosawa
authors: Orie
authors: O
authors: Watanabe
authors: Hitoshi
authors: H
authors: Maruyama
authors: Brian
authors: B
authors: Budgell