title: Development of inactivated poliovirus vaccine derived from Sabin strains.
abstract: In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys.
authors: Japan Poliomyelitis Research Institute, 5-34-4, Kumegawa-cho, Higashi-murayama, Tokyo 189-0003, Japan.
authors: B
authors: B
authors: Simizu
authors: S
authors: S
authors: Abe
authors: H
authors: H
authors: Yamamoto
authors: Y
authors: Y
authors: Tano
authors: Y
authors: Y
authors: Ota
authors: M
authors: M
authors: Miyazawa
authors: H
authors: H
authors: Horie
authors: K
authors: K
authors: Satoh
authors: K
authors: K
authors: Wakabayashi