Energetics of the Na(+) pump in the heart.
Movement of ions across the cell membrane is driven by the free energy released from ATP hydrolysis. Here we will briefly review the chemistry of Na(+), K(+)-ATPase reaction; we will also review some recent results defining the relationship between the energetic driving force and Na(+) efflux by the Na(+) pump in the normal myocardium and then discuss this relationship for pathophysiologic states in the heart.
Ingwall
Joanne S
JS
NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. jingwall@rics.bwh.harvard.edu
Balschi
James A
JA