Myelodysplastic syndromes with isolated deletion of the long arm of the chromosome X as a sole cytogenetic change.
Deletions of Xq are extremely rare events in myelodysplastic syndromes (MDS) patients and were previously described in five patients, in two of them as a sole chromosome abnormality. We found isolated del(Xq) in 3 of 127 MDS patients with clonal chromosome changes. Detailed analysis of clinical and morphological data of presented and previously published cases indicates the following: (1) del(X)(q24) and del(X)(q13) are nonrandom chromosomal abnormalities in MDS; (2) MDS with deletions of Xq affect exclusively females ages 46-65; and (3) deletions of Xq are associated with refractory anemia with excess blasts (RAEB) and indicate an unfavorable prognosis.
Olshanskaya
Yulia V
YV
Hematological Scientific Center, Novozykovsky pr. 4 A, 125167 Moscow, Russia. olsh@blood.ru
Udovichenko
Alla I
AI
Vodinskaya
Lubov A
LA
Glasko
Eugenia N
EN
Parovitchnikova
Elena N
EN
Lorie
Yurii Yu
YY
Dvirnik
Valentina N
VN
Savchenko
Valerii G
VG
Domracheva
Elena V
EV