Development of inactivated poliovirus vaccine derived from Sabin strains.
In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys.
Simizu
B
B
Japan Poliomyelitis Research Institute, 5-34-4, Kumegawa-cho, Higashi-murayama, Tokyo 189-0003, Japan.
Abe
S
S
Yamamoto
H
H
Tano
Y
Y
Ota
Y
Y
Miyazawa
M
M
Horie
H
H
Satoh
K
K
Wakabayashi
K
K