Straightforward entry to libraries of diversely substituted azinones by a consecutive aza-Michael/palladium-catalyzed functionalization strategy.
A highly divergent, flexible, and conceptually simple sequence allowing the parallel solution-phase assembly of functionalized azinone libraries has been developed in a one-pot consecutive fashion. Structural decoration of in situ-generated heterocyclic aza-Michael adducts AB was accomplished by exploiting the diversity potential of Heck, Suzuki, Sonogashira, and Stille reactions.
Coelho
Alberto
A
Departamento de Química Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Sotelo
Eddy
E