Regioselective carbene insertion on polysubstituted dihydroaromatic compounds.
[reaction: see text] The rhodium-catalyzed CH-insertion reaction of diazo ester derivatives into dihydroaromatic compounds was expanded to the application of various polysubstituted and functionalized 1,4-dienes generated from a cobalt-catalyzed Diels-Alder reaction. The highly regioselective CH-insertion process produces after DDQ oxidation polysubstituted, polyfunctionalized aromatic compounds in good overall yields.
Hilt
Gerhard
G
Fachbereich Chemie, Philipps-Universität Marburg, Germany. hilt@chemie.uni-marburg.de
Galbiati
Fabrizio
F