title: Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis.
abstract: BACKGROUND
  Transient splenium corporis callosi (SCC) lesions are related to rapid reduction of antiepileptic drugs (AEDs). The range of substances with predilection for SCC changes, their pathophysiology and their occurrence are still unknown.
  
  
  METHODS
  In a prospective 2-year study an epilepsy-dedicated MRI protocol supplemented by DWI and ADC maps was performed after AED withdrawal for diagnostic seizure provocation in all patients with pharmacoresistant seizures locally admitted to the Department of Epileptology.
  
  
  RESULTS
  Of 891 presurgical epilepsy patients, 6 (0.7%) had SCC lesions with cytotoxic edema on DWI. Carbamazepine combined with other AEDs was administered in five of those patients. In the study period we observed identical lesions in a schizophrenic patient treated with olanzapine and citalopram, in a patient with oropharyngeal carcinoma treated with alkylating agents, and in a hypernatremic patient following neurohypophyseal granular cell tumor surgery.
  
  
  CONCLUSIONS
  Transient SCC lesions are related to rapid AED reduction but may occur in similar conditions with fluid balance alterations. We contribute further clinical data in this field to better classify the pharmaceuticals that are prone to the described cerebral cytotoxic side effects in the SCC and to clarify their incidence among presurgical epilepsy patients.
authors: Department of Radiology/Neuroradiology, University of Bonn Medical Center, Sigmund Freud Str. 25, 53105 Bonn, Germany. michael.nelles@ukb.uni-bonn.de
authors: M
authors: M
authors: Nelles
authors: C G
authors: CG
authors: Bien
authors: M
authors: M
authors: Kurthen
authors: M
authors: M
authors: von Falkenhausen
authors: H
authors: H
authors: Urbach