Basic fibroblast growth factor promotes nerve regeneration in a C- -ion-implanted silicon chamber.
We reported previously that a silicone tube whose inner surface has been implanted with negatively charged carbon ions (C-) enables a nerve to regenerate across a 15-mm inter-stump gap. In this study, we investigated whether a C- -ion-implanted tube pretreated with basic fibroblast growth factor promotes peripheral nerve regeneration. The C- -ion-implanted tube significantly accelerated nerve regeneration, and this effect was enhanced by basic fibroblast growth factor.
Ikeguchi
Ryosuke
R
Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Kakinoki
Ryosuke
R
Matsumoto
Taiichi
T
Yamakawa
Tomoyuki
T
Nakayama
Ken
K
Morimoto
Yoshihide
Y
Tsuji
Hiroshi
H
Ishikawa
Junzo
J
Nakamura
Takashi
T