Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties.
A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).
Sassatelli
Mathieu
M
Laboratoire SEESIB, Université Blaise-Pascal, UMR 6504 du CNRS, 24 avenue des Landais, 63177 Aubière, France.
Debiton
Eric
E
Aboab
Bettina
B
Prudhomme
Michelle
M
Moreau
Pascale
P