title: Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
abstract: Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel gamma-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure-activity relationship studies of these compounds were also developed.
authors: Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
authors: Yasuko
authors: Y
authors: Takahashi
authors: Haruhiko
authors: H
authors: Fuwa
authors: Akane
authors: A
authors: Kaneko
authors: Makoto
authors: M
authors: Sasaki
authors: Satoshi
authors: S
authors: Yokoshima
authors: Hifumi
authors: H
authors: Koizumi
authors: Tohru
authors: T
authors: Takebe
authors: Toshiyuki
authors: T
authors: Kan
authors: Takeshi
authors: T
authors: Iwatsubo
authors: Taisuke
authors: T
authors: Tomita
authors: Hideaki
authors: H
authors: Natsugari
authors: Tohru
authors: T
authors: Fukuyama