title: Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
abstract: In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
authors: Department of Molecular Medicine and Surgery, Department of Medicine, Karolinska University Hospital, Stockholm, SE-171 76, Sweden.
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authors: Ekelund
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authors: Saaf
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authors: Tengvall-Linder
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authors: Melen
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authors: Barker
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authors: Pershagen
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authors: Wickman
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authors: Nordenskjold
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authors: Kockum
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authors: Bradley