Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst.
A direct asymmetric hydroxyamination reaction of aldehydes with nitrosobenzene was found to be catalyzed by the novel axially chiral secondary amine catalyst (S)-1d. The resulting optically enriched hydroxyamination products were readily converted to beta-amino alcohols or 1,2-diamines in one pot.
Kano
Taichi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Ueda
Mitsuhiro
M
Takai
Jun
J
Maruoka
Keiji
K