Expression of ACP6 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.
ACP6 (acid phosphatase 6, lysophosphatidic) is a lysophosphatidic acid (LPA)-specific phosphatase that hydrolyzes LPA to monoacylglycerol and is involved in lipid metabolism in the mitochondria. Its role in oncogenesis and cancer progression has not been studied. In this study, we examined the expression of ACP6 mRNA and evaluated its clinical significance in esophageal squamous cell carcinoma (ESCC). Expression of ACP6 mRNA was quantified by real-time reverse transcription polymerase chain reaction using the LightCycler in 70 esophageal ESCC specimens and their paired normal esophageal mucosa. The data were analyzed with reference to clinicopathological factors. ACP6 mRNA expression in esophageal cancer tissue was significantly lower than that in corresponding normal esophageal mucosa (P=0.0301). Among the esophageal cancer tissues, ACP6 mRNA expression significantly correlated with local tumor invasion (T factor, P=0.0461) and lymph node metastasis (P=0.0128). Furthermore, low ACP6 mRNA expression was associated with a significantly shorter survival time compared with high expression (log-rank test, P=0.0358). In multivariate analysis, ACP6 mRNA expression emerged as a significant independent factor (P=0.0148). Impaired ACP6 expression may lead to more aggressive invasion of ESCC, and ACP6 mRNA expression level could be an independent prognostic factor for patients with ESCC.
Ando
Takuya
T
Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Nagoya 467-8601, Japan.
Ishiguro
Hideyuki
H
Kuwabara
Yoshiyuki
Y
Kimura
Masahiro
M
Mitsui
Akira
A
Kurehara
Hiroki
H
Sugito
Nobuyoshi
N
Tomoda
Keisuke
K
Mori
Ryota
R
Takashima
Nobuhiro
N
Ogawa
Ryo
R
Fujii
Yoshitaka
Y