New molecular target for modulation of aging process.
Despite many endeavors, no satisfactory strategy has emerged for modulating the aging process, most probably because they were based on faulty rationales. In an extension of the "gate theory of aging" that we proposed recently, we propose here that caveolin, an essential component of caveolae structure, may offer a potential target for modulating the aging process. According to the gate theory, certain biomolecules such as caveolins, amphiphysins, G proteins, and integrins play decisive roles in determining the senescent phenotype and thus provide targets for modulating the aging process. Among these molecules, we chose caveolin, because it can associate with a variety of regulatory and structural molecules via their scaffolding domains and thereby influence a broad spectrum of biological phenomena including both the physiology and morphology of the senescent cells. This is an attempt to review the vast body of evidence available in the literature, both direct and indirect, supporting the accord of this pivotal role to the caveolin in the background of the gate theory for the aging process.
Park
Sang Chul
SC
Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center, Seoul National University College of Medicine, Seoul, South Korea. scpark@snu.ac.kr