title: [Genetic mechanisms in the hereditary predisposition to colorectal cancer].
abstract: A proportion of colorectal cancers shows some type of genetic predisposition that can be recognised in clinical practice. From the classical dominant inheritance pattern of familial adenomatous polyposis or hereditary non-polyposis colorectal cancer, through the recessive transmission of the MYH associated polyposis, to the new syndromes of the "serrated pathway" or low-penetrance alleles, the discovery of new genes and a deeper understanding of the mechanisms of action of already-known ones are enabling us to understand new aspects of the colorectal carcinogenesis. This is throwing a new light on some of the observed familial aggregation patterns which had remained unexplained.
authors: Servicio de Genética, Hospital Virgen del Camino, Pamplona. aalonsos@cfnavarra.es
authors: A
authors: A
authors: Alonso
authors: S
authors: S
authors: Moreno
authors: A
authors: A
authors: Valiente
authors: M
authors: M
authors: Artigas
authors: A
authors: A
authors: Pérez-Juana
authors: M A
authors: MA
authors: Ramos Arroyo