title: Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia.
abstract: Many acute lymphoblastic leukemias can be considered as malignant counterparts of cells in the various stages of normal lymphoid development in bone marrow and thymus. T-cell development in the thymus is an ordered and tightly controlled process. Two evolutionary conserved signaling pathways, which were first discovered in Drosophila, control the earliest steps of T-cell development. These are the Notch and Wnt-signaling routes, which both are deregulated in several types of leukemias. In this review we discuss both pathways, with respect to their signaling mechanisms, functions during T-cell development and their roles in development of leukemias, especially T-cell acute lymphoblastic leukemia.
authors: Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: F
authors: F
authors: Weerkamp
authors: J J M
authors: JJ
authors: van Dongen
authors: F J T
authors: FJ
authors: Staal