Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
Loeffler
Juergen
J
Julius-Maximilians-Universität Würzburg, Medizinische Klinik II, 97070 Würzburg, Germany. loeffler_j@klinik.uni-wuerzburg.de
Steffens
Michael
M
Arlt
Eva-Maria
EM
Toliat
Mohammad-Reza
MR
Mezger
Markus
M
Suk
Anita
A
Wienker
Thomas F
TF
Hebart
Holger
H
Nürnberg
Peter
P
Boeckh
Michael
M
Ljungman
Per
P
Trenschel
Rudolf
R
Einsele
Hermann
H