Markedly enhancing lipase-catalyzed synthesis of nucleoside drugs' ester by using a mixture system containing organic solvents and ionic liquid.
Eightfold higher yields and three times faster reaction rates were achieved by means of using a mixture solvent system composed of 90% acetone and 10% [BMIM]BF4 in the lipase-catalyzed regioselective synthesis of polymerizable ester of nucleoside drugs.
Liu
Bo Kai
BK
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Wang
Na
N
Chen
Zhi Chun
ZC
Wu
Qi
Q
Lin
Xian Fu
XF