title: The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.
abstract: We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.
authors: Fabio
authors: F
authors: Timeus
authors: Nicoletta
authors: N
authors: Crescenzio
authors: Emanuela
authors: E
authors: Ricotti
authors: Alessandra
authors: A
authors: Doria
authors: Daniele
authors: D
authors: Bertin
authors: Giuseppe
authors: G
authors: Saglio
authors: Pier Angelo
authors: PA
authors: Tovo