Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.
Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.
Dheenadhayalan
Veerabadran
V
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
Delogu
Giovanni
G
Sanguinetti
Maurizio
M
Fadda
Giovanni
G
Brennan
Michael J
MJ