Helicobacter pylori initiates the stringent response upon nutrient and pH downshift.
Helicobacter pylori was previously reported to lack a stringent response. In contrast, we show that after nutrient downshift, H. pylori produced abundant ppGpp and less total RNA. pH downshift also caused (p)ppGpp accumulation. Our observations indicate that nutrient deprivation and acid shock activate the stringent response in H. pylori.
Wells
Derek H
DH
Department of Biological Sciences, Stanford University, California, USA.
Gaynor
Erin C
EC