Nutrient determinants of postprandial triglyceride response in a population-based sample of type II diabetic patients.
BACKGROUND
Nutrient determinants of postprandial triglyceride (TG) are matter of debate, especially for type II diabetes.


OBJECTIVE
This study was performed to evaluate the impact of dietary habits on postprandial TG response in a population-based sample of type II diabetic patients.


METHODS
One-hundred and forty type II diabetic patients (63 men/77 women, age 45-70 years) referring to the same health district, not on hypolipidemic drugs and without any other chronic disease, performed four TG profiles (at fasting, before, 2 and 3 h after lunch) with a specific device (Accutrend GCT, Roche Diagnostics Mannheim, Germany) validated previously. Dietary habits were recorded by a dietitian utilizing a previously validated semiquantitative questionnaire.


RESULTS
Triglyceride values (mmol/l, mean +/- s.d.) were 2.22 +/- 0.93 at fasting, decreased before lunch (2.03 +/- 0.81), reached peak values 3 h after lunch (2.73 +/- 1.11). Postprandial TG increments (3 h after lunch minus pre-lunch concentration) significantly correlated with the intake (g/day) of animal protein (r = 0.20, P < 0.02), total fat (r = 0.21, P < 0.01), animal fat (r = 0.19, P < 0.03) and vegetable fat (r = 0.19, P < 0.03), also after adjusting for fasting TG and high-density lipoprotein cholesterol levels. Expressing nutrient intake as percentage of total calorie intake, total and animal fat remained significantly and directly related to postprandial TG increment (r = 0.21, P < 0.01 for total fat; r = 0.19, P < 0.03 for animal fat) whereas the percentage of carbohydrates was inversely related (r = -0.23, P < 0.007).


CONCLUSIONS
Fat intake seems the major nutritional determinant of postprandial TG response in type II diabetic patients.
Rivellese
A A
AA
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. rivelles@unina.it
Iovine
C
C
Ciano
O
O
Costagliola
L
L
Galasso
R
R
Riccardi
G
G
Vaccaro
O
O