title: Nanotube confinement denatures protein helices.
abstract: In striking contrast to simple polymer physics theory, which does not account for solvent effects, we find that physical confinement of solvated biopolymers decreases solvent entropy, which in turn leads to a reduction in the organized structural content of the polymer. Since our theory is based on a fundamental property of water-protein statistical mechanics, we expect it to have broad implications in many biological and material science contexts.
authors: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
authors: Eric J
authors: EJ
authors: Sorin
authors: Vijay S
authors: VS
authors: Pande