title: Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study.
abstract: OBJECTIVE
  Risks of hepatocellular carcinoma (HCC) following hepatitis B and/or hepatitis C virus (HBV/HCV) infection are well known, those for other cancers are less well understood. The aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV infections.
  
  
  METHODS
  The data from a cohort of 39109 HBV, 75834 HCV, and 2604 HBV/HCV co-infected persons notified to the State health department, 1990-2002, were probabilistically linked to the Cancer Registry and standardised incidence ratios (SIRs) for cancer were calculated.
  
  
  RESULTS
  The match rate for any cancer was 2.7%, 2.3% and 3.3% for HBV, HCV and HBV/HCV co-infected notifications. SIRs for HCC were 30.6 (95% CI 25.7-36.5), 22.7 (95% CI 19.1-26.5) and 30.3 (95% CI 13.6-67.5), respectively. Increased risk was detected for Burkitt's lymphoma and HBV (SIR 12.9, 95% CI 5.4-30.9) and immunoproliferative malignancies following HCV (SIR 5.6, 95% CI 1.8-17.5).
  
  
  CONCLUSIONS
  The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated cancers. The modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings.
authors: National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia. jamin@nchecr.unsw.edu.au
authors: Janaki
authors: J
authors: Amin
authors: Gregory J
authors: GJ
authors: Dore
authors: Dianne L
authors: DL
authors: O'Connell
authors: Mark
authors: M
authors: Bartlett
authors: Elizabeth
authors: E
authors: Tracey
authors: John M
authors: JM
authors: Kaldor
authors: Matthew G
authors: MG
authors: Law