title: Apolipoprotein A-I possessing activity of defensin proteins modifies structure of plasma membranes.
abstract: We studied the in vitro effect of apolipoprotein A-I possessing activity of defensin proteins on the structure of plasma membranes in donor erythrocytes and lymphocytes. Incubation of erythrocyte membranes with apolipoprotein A-I was accompanied by significant changes in biophysical characteristics of a fluorescent probe pyrene in the hydrophobic membrane region and a decrease in Na+/K(+)-ATPase activity. Microviscosity of annular lipids in the plasma membrane of lymphocytes increased during incubation with apolipoprotein A-I. Our results suggest that membranotropic activity of apolipoprotein A-I is associated with the presence of amphipathic alpha-helix regions.
authors: Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors: L E
authors: LE
authors: Panin
authors: N V
authors: NV
authors: Ryazantseva
authors: V V
authors: VV
authors: Novitskii
authors: N V
authors: NV
authors: Tokareva