Closing the GAP between polarity and vesicle transport.
How are tight junctions maintained? In this issue of Cell, Wells et al. (2006) provide intriguing evidence for a new pathway that links polarity proteins and vesicle transport to the maintenance of tight junctions, through the control of Cdc42 by Rich1, a GTPase-activating protein.
Macara
Ian G
IG
Center for Cell Signaling, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA. imacara@virginia.edu
Spang
Anne
A