title: Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer.
abstract: The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.
authors: ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal. sandracostas@portugalmail.com
authors: Sandra
authors: S
authors: Costa
authors: Daniela
authors: D
authors: Pinto
authors: Deolinda
authors: D
authors: Pereira
authors: André
authors: A
authors: Vasconcelos
authors: Carlos
authors: C
authors: Afonso-Lopes
authors: Teresa
authors: T
authors: Osório
authors: Carlos
authors: C
authors: Lopes
authors: Rui
authors: R
authors: Medeiros