Cross validation of experts versus registration methods for target localization in deep brain stimulation.
In the last five years, Deep Brain Stimulation (DBS) has become the most popular and effective surgical technique for the treatent of Parkinson's disease (PD). The Subthalamic Nucleus (STN) is the usual target involved when applying DBS. Unfortunately, the STN is in general not visible in common medical imaging modalities. Therefore, atlas-based segmentation is commonly considered to locate it in the images. In this paper, we propose a scheme that allows both, to perform a comparison between different registration algorithms and to evaluate their ability to locate the STN automatically. Using this scheme we can evaluate the expert variability against the error of the algorithms and we demonstrate that automatic STN location is possible and as accurate as the methods currently used.
Sánchez Castro
F Javier
FJ
Signal Processing Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. francisco.sanchezcastro@epfl.ch
Pollo
Claudio
C
Meuli
Reto
R
Maeder
Philippe
P
Cuadra
Meritxell Bach
MB
Cuisenaire
Olivier
O
Villemure
Jean-Guy
JG
Thiran
Jean-Philippe
JP