Cellular uptake of PNA--terpyridine conjugates and its enhancement by Zn2+ ions.
Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2':6',2' '-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.
Füssl
Andreas
A
European Molecular Biology Laboratory (EMBL) Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Schleifenbaum
Andreas
A
Göritz
Mareike
M
Riddell
Andrew
A
Schultz
Carsten
C
Krämer
Roland
R