title: Nanopore formation and phosphatidylserine externalization in a phospholipid bilayer at high transmembrane potential.
abstract: Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PS externalization in living cells exposed to nanosecond, megavolt-per-meter electric pulses. Nanometer-diameter aqueous pores develop within nanoseconds after application of an electric field of 450 mV/nm, and electrophoretic transport of the anionic PS headgroup along the newly constructed hydrophilic pore surface commences even while pore formation is still in progress.
authors: MOSIS, Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Marina del Rey, California 90292, USA. vernier@mosis.org
authors: P Thomas
authors: PT
authors: Vernier
authors: Matthew J
authors: MJ
authors: Ziegler
authors: Yinghua
authors: Y
authors: Sun
authors: Wenji V
authors: WV
authors: Chang
authors: Martin A
authors: MA
authors: Gundersen
authors: D Peter
authors: DP
authors: Tieleman