A common variant associated with prostate cancer in European and African populations.
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
Amundadottir
Laufey T
LT
deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Sulem
Patrick
P
Gudmundsson
Julius
J
Helgason
Agnar
A
Baker
Adam
A
Agnarsson
Bjarni A
BA
Sigurdsson
Asgeir
A
Benediktsdottir
Kristrun R
KR
Cazier
Jean-Baptiste
JB
Sainz
Jesus
J
Jakobsdottir
Margret
M
Kostic
Jelena
J
Magnusdottir
Droplaug N
DN
Ghosh
Shyamali
S
Agnarsson
Kari
K
Birgisdottir
Birgitta
B
Le Roux
Louise
L
Olafsdottir
Adalheidur
A
Blondal
Thorarinn
T
Andresdottir
Margret
M
Gretarsdottir
Olafia Svandis
OS
Bergthorsson
Jon T
JT
Gudbjartsson
Daniel
D
Gylfason
Arnaldur
A
Thorleifsson
Gudmar
G
Manolescu
Andrei
A
Kristjansson
Kristleifur
K
Geirsson
Gudmundur
G
Isaksson
Helgi
H
Douglas
Julie
J
Johansson
Jan-Erik
JE
Bälter
Katarina
K
Wiklund
Fredrik
F
Montie
James E
JE
Yu
Xiaoying
X
Suarez
Brian K
BK
Ober
Carole
C
Cooney
Kathleen A
KA
Gronberg
Henrik
H
Catalona
William J
WJ
Einarsson
Gudmundur V
GV
Barkardottir
Rosa B
RB
Gulcher
Jeffrey R
JR
Kong
Augustine
A
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K