title: Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.
abstract: Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.
authors: Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
authors: Orla K
authors: OK
authors: Mc Carthy
authors: Alessandro
authors: A
authors: Schipani
authors: Alex Musso
authors: AM
authors: Buendía
authors: Luis M
authors: LM
authors: Ruiz-Perez
authors: Marcel
authors: M
authors: Kaiser
authors: Reto
authors: R
authors: Brun
authors: Dolores González
authors: DG
authors: Pacanowska
authors: Ian H
authors: IH
authors: Gilbert