title: [Synthesis of phenyloxyisobutyric acid derivatives and their antidiabetic activity in vitro].
abstract: OBJECTIVE
  To design and synthesize new phenyloxyisobutyric acid analogues as antidiabetic compounds.
  
  
  METHODS
  Eight new target compounds were synthesized by combination of lipophilic moieties and acidic moiety with nucleophilic replacement or Mitsunobu condensation. The eight compounds were confirmed by 1H NMR, 13C NMR, IR and MS.
  
  
  RESULTS
  In vitro insulin-sensitizing activity (3T3-L1 adipocyte) demonstrated, that the cultured glucose concentration of up-clear solution detected with GOD-POD assay were 5.942, 6.339, 6.226 and 6.512 mmol x L(-1), respectively, when rosiglitazone, pioglitazone, compounds A and B were added to the insulin-resistant system.
  
  
  CONCLUSIONS
  In vitro insulin-sensitizing activity of target compound A is in between that of rosiglitazone and pioglitazone, and activity of target compound B is slightly less than that of pioglitazone.
authors: Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China. qlzeng@xmu.edu.cn
authors: Qing-le
authors: QL
authors: Zeng
authors: He-qing
authors: HQ
authors: Wang
authors: Huan
authors: H
authors: Luo
authors: Xiao-ping
authors: XP
authors: Gao
authors: Zhong-rong
authors: ZR
authors: Liu
authors: Bo-gang
authors: BG
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