title: Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
abstract: Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.
authors: Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Wellcome Trust Research Laboratories, PO Box 43640, Nairobi, Kenya. anzila@wtnairobi.mimcom.net
authors: Alexis M
authors: AM
authors: Nzila
authors: Gilbert
authors: G
authors: Kokwaro
authors: Peter A
authors: PA
authors: Winstanley
authors: Kevin
authors: K
authors: Marsh
authors: Steve A
authors: SA
authors: Ward