Activity of angiotensin-converting enzyme in hereditary stress-induced arterial hypertension.
We measured activity of angiotensin-converting enzyme in plasma and tissue of NISAG and normotensive WAG rats. In different organs of NISAG rats, activity of this enzyme did not differ from the corresponding values of WAG rats, although enzyme activity in the plasma of NISAG rats was significantly lower than that of WAG rats. Since NISAG rats are characterized by low activity of renin in the renal cortex, it is hypothesized that NISAG rats simulate the low-renin hypertension, in which inhibition of activity of the angiotensin-production system results from elevation of arterial pressure of central origin.
Cherkasova
O P
OP
Institute of Laser Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. chrom@laser.nsc.ru
Fedorov
V I
VI
Markel
A L
AL