Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum.
BACKGROUND
A 64-year-old woman presented to the emergency room with a 3-month history of intermittent abdominal cramps, accompanied by nausea, vomiting, anorexia, and decreased bowel movements consistent with a partial intestinal obstruction. She had a 12-year history of peptic ulcers, which had been treated with histamine-2 blockers.


METHODS
Physical examination, abdominal X-ray, abdominal CT scan, colonoscopy and assessment of gastrin levels.


METHODS
Duodenal neuroendocrine neoplasm showing gastrin expression and stage III (T3N2M0), poorly differentiated adenocarcinoma of the cecum arising from hyperplastic polyposis.


RESULTS
Right-sided hemicolectomy with ileocolonic anastomosis, duodenal resection, leucovorin and 5-fluorouracil chemotherapy, annual colonoscopic surveillance, and polypectomy.
Goswami
Rashmi S
RS
Anatomic Pathology, McGill University, Montreal, QC, Canada.
Minoo
Parham
P
Baker
Kristi
K
Chong
George
G
Foulkes
William D
WD
Jass
Jeremy R
JR