title: Secular trends of blood isolates in patients from a rural area population hospitalized in a tertiary center in a small city in Greece.
abstract: BACKGROUND
  Most of the studies evaluating the secular trends of blood isolates come from tertiary hospitals in urban areas. We sought to study the trends of the antimicrobial resistance of blood isolates in patients from a rural population hospitalized in a tertiary hospital in a small city in Greece.
  
  
  METHODS
  We retrospectively collected and analysed data for the first positive blood culture obtained for each admission for each patient hospitalized in General Hospital of Tripolis, Tripolis, Peloponnesus, Greece during a 5 year period (16/05/2000-15/05/2005).
  
  
  RESULTS
  Sixty-seven thousand and seventy patients were hospitalized during the study period from whom 3,206 blood cultures were obtained. A higher increase of the number of obtained blood cultures than the number of admissions was noted during the study period (p < 0.001). Three hundred and seventy-three (11.6%) blood cultures were positive. Coagulase-negative staphylococci (35.9%), Escherichia coli (29%), and Staphylococcus aureus (18.2%) were the most commonly isolated pathogens. Among the Staphylococcus aureus isolates, the proportion of methicillin-resistant Staphylococcus aureus (MRSA) was 17.2% (5/29). The proportion of Escherichia coli resistant to trimethoprim and sulfamethoxazole, ampicillin and cefuroxime was 29.6% (32/108), 25.0% (27/108), and 8.3% (9/108) respectively. Imipenem-resistance was noted in 3.4% (1/29) of Pseudomonas aeruginosa isolates. There were only 6 (1.6%) Acinetobacter baummanii blood isolates during the study period.
  
  
  CONCLUSIONS
  The antimicrobial resistance of isolates from patients receiving care at the studied tertiary hospital in a small city in Greece is considerably less compared to that noted in tertiary hospitals in larger cities of the country.
authors: Alfa Institute of Biomedical Sciences, Athens, Greece. m.falagas@aibs.gr
authors: Matthew E
authors: ME
authors: Falagas
authors: Alexandra
authors: A
authors: Bakossi
authors: Vasilis D
authors: VD
authors: Pappas
authors: Pierros V
authors: PV
authors: Holevas
authors: Antonis
authors: A
authors: Bouras
authors: Eleni
authors: E
authors: Stamata