title: The intrinsic mechanisms underlying the maturation of programming sequential spikes at cerebellar Purkinje cells.
abstract: Cerebellum is involved in the motion coordination and working memory, to which the programming of sequential spikes at Purkinje cells is essential. It is not clear about the intrinsic mechanisms underlying spike capacity and timing precision as well as their postnatal maturation. We investigated the programming and intrinsic property of sequential spikes at Purkinje neurons during postnatal development by whole-cell recording in cerebellar slices. Cerebellar Purkinje neurons demonstrate the increasing of spike capacity and timing precision, as well as the lowering of refractory periods and threshold potentials during the postnatal maturation. In addition, the correlation between spike parameters and intrinsic properties converts to be more linear. This postnatal plasticity of neuronal intrinsic properties improves the timing precision and capacity of spike programming at cerebellar Purkinje neurons.
authors: Department of Physiology, Bengbu Medical College, Anhui 233000, China.
authors: Sudong
authors: S
authors: Guan
authors: Shanfeng
authors: S
authors: Ma
authors: Yan
authors: Y
authors: Zhu
authors: Rongjin
authors: R
authors: Ge
authors: Qiyi
authors: Q
authors: Wang
authors: Jin-Hui
authors: JH
authors: Wang