Novel class of cyclophosphamide prodrug: cyclophosphamide spiropiperaziniums (CPSP).
A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure-activity relationships were revealed.
Sun
Qi
Q
School of Pharmaceutical Science, Peking University, Beijing 100083, PR China.
Li
Run-Tao
RT
Guo
Wei
W
Cui
Jing-Rong
JR
Cheng
Tie-Ming
TM
Ge
Ze-Mei
ZM