3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand?
The pK(a) value and iron affinity constants for 3-hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one 1 have been determined by spectrophotometry using aqueous methanol solutions. The extrapolated affinity constants beta(1), beta(2), and beta(3)( )()for iron(III) in aqueous solution were 9.95, 18.69, and 26.02, respectively, with a corresponding pFe(3+) value of 14.64. Job plot and MS spectra data demonstrated that the 3:1 species is favored at pH 7.0. These results indicate that 1 acts as a bidentate ligand when coordinated to iron(III).
Kong
Xiaole
X
Pharmacy Department and Drug Control Centre/Mass Spectrometry Facility, King's College London, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, UK.
Zhou
Tao
T
Neubert
Hendrik
H
Liu
Zudong
Z
Hider
Robert C
RC