A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.
The title compound, C30H46O9, prepared from a mixture of alpha- and beta-dihydroartemisinin, has alpha- and beta-arteether moieties linked via an -O- bridge, so that the molecule is asymmetric about the bridge. The endoperoxide bridges of the parent compounds have been retained in each half of the ether-bridged dimer. The rings exhibit chair and twist-boat conformations.
Yue
Zheng Yu
ZY
School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China. yuezhengyu@vip.sina.com
Li
Shu Hui
SH
Gao
Po
P
Zhang
Jin Hui
JH
Yan
Peng Fei
PF