Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template.
The HCV NS3 protease is essential for replication of the hepatitis C virus (HCV) and therefore constitutes a promising new drug target for anti-HCV therapy. Several potent and promising HCV NS3 protease inhibitors, some of which display low nanomolar activities, were identified from a series of novel inhibitors incorporating a trisubstituted cyclopentane dicarboxylic acid moiety as a surrogate for the widely used N-acyl-(4R)-hydroxyproline in the P2 position.
Johansson
Per-Ola
PO
Department of Chemistry, Linköping University, S-581 83 Linköping, Sweden.
Bäck
Marcus
M
Kvarnström
Ingemar
I
Jansson
Katarina
K
Vrang
Lotta
L
Hamelink
Elizabeth
E
Hallberg
Anders
A
Rosenquist
Asa
A
Samuelsson
Bertil
B