title: Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies.
abstract: BACKGROUND
  Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.
  
  
  METHODS
  Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction.
  
  
  RESULTS
  151 patients' blood samples were collected. Genotyping of GST polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies.
  
  
  CONCLUSIONS
  Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety.
authors: Pharmacogenomic Unit, RDES SL, Barcelona, Spain. josevidal@ub.edu
authors: Jose M
authors: JM
authors: Vidal-Taboada
authors: Mercedes
authors: M
authors: Cucala
authors: Sergio
authors: S
authors: Mas Herrero
authors: Amalia
authors: A
authors: Lafuente
authors: Albert
authors: A
authors: Cobos