Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening.
To report the major intraretinal pathological changes in retinas with proliferative vitreoretinopathy (PVR) and retinal shortening, 13 human retinal samples from postoperative PVR after primary surgery for retinal detachment were immunostained for vimentin, glial fibrillary acidic protein (GFAP), cytokeratins, and CD68. One more sample was studied with electron microscopy. Retinal disorganization, neuronal loss, and gliosis were observed in 12 out of 13 samples, but all 13 were positive for GFAP. Muller cell processes showed different degrees of intermediate filament hyperplasia. CD68-positive cells were present in 11 of 13 retinal samples.


CONCLUSIONS
A gliotic response plays a major role in retinal shortening in PVR. In addition, the presence of macrophage-like cells in retinal tissues suggests a possible role of these cells in the pathogenesis of this variety of PVR.
Pastor
J Carlos
JC
Grupo de Retina, Instituto Universitario de Oftalmobiología Aplicada (IOBA), Instituto de Neurociencias de Castilla y León, Universidad de Valladolid, Avda. Ramón y Cajal 7, ES-47005 Valladolid, Spain. pastor@ioba.med.uva.es
Méndez
M Carmen
MC
de la Fuente
Miguel A
MA
Coco
Rosa M
RM
García-Arumí
José
J
Rodríguez de la Rúa
Enrique
E
Fernández
Nieves
N
Saornil
M Antonia
MA
Gayoso
Manuel J
MJ