A facile, general synthesis of 3,4-difluoro-6-substituted-2-pyrones.
Reaction of (2E)-2,3-difluoro-3-iodoacrylic acid with a variety of terminal acetylenes under cocatalysis of PdCl2(PPh3)2 and CuI gave difluorinated 2-pyrones as the sole product in good yields.
Wang
Yi
Y
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Burton
Donald J
DJ