Estradiol-dependent effect of nitric oxide on meiotic maturation of mouse oocytes.
Estradiol dipropionate decreased the number of oocytes in mouse ovary and suppressed meiotic maturation of these cells. Administration of NO donors sodium nitroprusside and S-nitroso-N-acetylpenicillamine increased the ability of ovarian oocytes to complete meiotic maturation and counteracted the effect of estradiol dipropionate. Our results suggest that estradiol is involved in the regulation of production and release of ovarian NO.
Voznesenskaya
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Department of Immunology and Cytotoxic Sera, A. A. Bogomolets Institute of Physiology, Ukrainian Academy of Sciences, Kiev. imm@biph.kiev.ua
Blashkiv
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