title: Improvement of radiological penumbra using intermediate energy photons (IEP) for stereotactic radiosurgery.
abstract: Using efficient immobilization and dedicated beam collimation devices, stereotactic radiosurgery ensures highly conformal treatment of small tumours with limited microscopic extension. One contribution to normal tissue irradiation remains the radiological penumbra. This work aims at demonstrating that intermediate energy photons (IEP), above orthovoltage but below megavoltage, improve dose distribution for stereotactic radiosurgery for small irradiation field sizes due to a dramatic reduction of radiological penumbra. Two different simulation systems were used: (i) Monte Carlo simulation to investigate the dose distribution of monoenergetic IEP between 100 keV and 1 MeV in water phantom; (ii) the Pinnacle3 TPS including a virtual IEP unit to investigate the dosimetry benefit of treating with 11 non-coplanar beams a 2 cm tumour in the middle of a brain adjacent to a 1 mm critical structure. Radiological penumbrae below 300 microm are generated for field size below 2 x 2 cm2 using monoenergetic IEP beams between 200 and 400 keV. An 800 kV beam generated in a 0.5 mm tungsten target maximizes the photon intensity in this range. Pinnacle3 confirms the dramatic reduction in penumbra size. DVHs show for a constant dose distribution conformality, improved dose distribution homogeneity and better sparing of critical structures using a 800 kV beam compared to a 6 MV beam.
authors: Department of Medical Biophysics, Sunnybrook and Women's Health Sciences Centre, 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada.
authors: Lauren
authors: L
authors: O'Malley
authors: Jean-Philippe
authors: JP
authors: Pignol
authors: David J
authors: DJ
authors: Beachey
authors: Brian M
authors: BM
authors: Keller
authors: Joseph
authors: J
authors: Presutti
authors: Michael
authors: M
authors: Sharpe