title: The "presyrinx" state: is there a reversible myelopathic condition that may precede syringomyelia?
abstract: OBJECTIVE
  Alteration of cerebrospinal fluid (CSF) flow has been proposed as an important mechanism leading to the development of syringomyelia. We hypothesize that a "presyrinx" condition due to potentially reversible alteration in normal CSF flow exists and that its appearance may be due to variations in the competence of the central canal of the spinal cord.
  
  
  METHODS
  Five patients with clinical evidence of myelopathy, no history of spinal cord trauma, enlargement of the cervical spinal cord with T1 and T2 prolongation but no cavitation, evidence for altered or obstructed CSF flow, and no evidence of intramedullary tumor or a spinal vascular event underwent MR imaging before and after intervention that alleviated obstruction to CSF flow.
  
  
  RESULTS
  Preoperatively, all patients demonstrated enlarged spinal cords and parenchymal T1 and T2 prolongation without cavitation. Results of magnetic resonance (MR) imaging examinations following intervention in all patients showed resolution of cord enlargement and normalization or improvement of cord signal abnormalities. In one patient with severe arachnoid adhesions who initially improved following decompression, late evolution into syringomyelia occurred in association with continued CSF obstruction.
  
  
  CONCLUSIONS
  Nontraumatic obstruction of the CSF pathways in the spine may result in spinal cord parenchymal T2 prolongation that is reversible following restoration of patency of CSF pathways. We refer to this MR appearance as the "presyrinx" state and stress the importance of timely intervention to limit progression to syringomyelia.
authors: Department of Radiology, University of California, San Francisco, California 94143-0628, USA. Nancy.Fischbein@radiology.ucsf.edu
authors: N J
authors: NJ
authors: Fischbein
authors: W P
authors: WP
authors: Dillon
authors: C
authors: C
authors: Cobbs
authors: P R
authors: PR
authors: Weinstein