[Antifungal susceptibility testing of commensal and pathogenic clinical isolates of oral Candida].
OBJECTIVE
To evaluate and compare the sensitivity and resistance of commensal and pathogenic oral Candida to antifungal agents.


METHODS
YBC Test Kit was used to identify species of commensal and pathogenic oral Candida; The in vitro susceptibilities of oral Candida to 5-flucytosine (5-FC), itraconazole (ITR) and fluconazole (FLU) were determined by NCCLS M27-A2 method.


RESULTS
All strains were sensitive to 5-flucytosine, drug resistant strains to fluconazole and itraconazole were found both in commensal and pathogenic oral Candida spp; The proportion of no-C. albicans and antifungal drug resistant strains isolated from head and neck cancer patients treated with radiotherapy or chemotherapy were higher than oral commensal Candida and oral Candidiasis.


CONCLUSIONS
The no-C. albicans and drug resistant strains to fluconazole and itraconazole can be found both in commensal and pathogenic oral Candida spp now.
Zhao
Min
M
Department of Stomatology, Shandong University Shandong Provincial Hospital, Jinan 250021, China. zhaomin333@hotmail.com
Zhou
Zeng-tong
ZT