Stimulation of macrophages increases, while suppression of these cells inhibits metastatic dissemination of two transplantable mouse tumors in the liver and lungs.
Stimulation of mouse tissue macrophages with carboxymethylated beta-(1-->43)-D-glycan 1 day before intravenous injection of tumor cells increased the number and weight of implants (experimental metastases) of mouse hepatocarcinoma and adenocarcinoma in the liver and lungs, respectively. Suppression of liver macrophages with gadolinium chloride or sequestration of cells during intraperitoneal administration of macrophage attractants inhibited metastatic dissemination of hepatocarcinoma and adenocarcinoma in the liver and lungs, respectively. In the latter case animal lifespan increased. Our results indicate that at certain stages of metastatic dissemination, activation of mononuclear phagocytes can stimulate the formation and growth of metastases.
Zhanaeva
S Y
SY
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. djsja@mail.ru
Korolenko
T A
TA
Nekrasov
B G
BG
Nikolin
V P
VP
Kaledin
V I
VI