title: Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.
abstract: Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling.
authors: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
authors: S
authors: S
authors: Kelly
authors: W
authors: W
authors: Singleton
authors: B
authors: B
authors: Wickstead
authors: K
authors: K
authors: Ersfeld
authors: K
authors: K
authors: Gull