title: Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity.
abstract: We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.
authors: Institute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany.
authors: Alexander W
authors: AW
authors: Friedrich
authors: Shan
authors: S
authors: Lu
authors: Martina
authors: M
authors: Bielaszewska
authors: Rita
authors: R
authors: Prager
authors: Phillip
authors: P
authors: Bruns
authors: Jian-Guo
authors: JG
authors: Xu
authors: Helmut
authors: H
authors: Tschäpe
authors: Helge
authors: H
authors: Karch