Double heterozygotes for non-Caucasian families with mutations in BRCA-1 and BRCA-2 genes.
The recent discovery of the BRCA-1 and BRCA-2 genes as contributing factors to hereditary breast cancer has significantly improved our understanding of familial breast cancer. Deleterious mutations in both BRCA-1 and BRCA-2 in an individual patient is exceedingly rare, with few case reports in the literature, particularly among non-Caucasian, non-Jewish families. We describe here two cases of deleterious mutations in both genes in a cohort of Korean women with early onset breast cancer.
Choi
Doo Ho
DH
Department of Radiation Oncology and Surgery, College of Medicine, Soonchungyang University, Seoul, Korea.
Lee
Min Hyuk
MH
Haffty
Bruce G
BG