Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer.
The recognition of recurrent aberrant regions in cancer is important to the discovery of candidate cancer related genes. Here we first constructed a genome-wide gene expression map of squamous lung carcinoma from the Stanford Microarray Database. High-resolution detection of aberrant chromosomal regions was performed by using moving-median method. 84% (27 of 32) of our results were consistent with the previous studies of comparative genomic hybridization or loss of heterozygosity. One overrepresented region in Xq28 was newly discovered to be related to squamous cell lung carcinoma. These observations could be of great interest for further studies.
Zhang
Xin-Yu
XY
Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, PR China.
Hu
Ying
Y
Cui
Yong-Ping
YP
Miao
Xiao-Ping
XP
Tian
Feng
F
Xia
Yong-Jing
YJ
Wu
Yi-Qing
YQ
Liu
Xiangjun
X