IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.
IC31, the combination of a novel immunostimulatory oligodeoxynucleotide containing deoxy-Inosine/deoxy-Cytosine (ODN1a) and the antimicrobial peptide KLKL(5)KLK, represents a promising novel adjuvant signaling via the TLR9/MyD88-dependent pathway of the innate immune system. In mice, IC31 induces potent peptide-specific type 1 cellular immune responses, as well as mainly type 1 dominated protein-specific cellular and humoral immune responses. In addition, cytotoxic T lymphocytes were induced, able to kill efficiently target cells in vivo. Activation of murine dendritic cells by IC31 induced efficiently proliferation of naïve CD4(+) TCR transgenic T cells (DO.11.10) as well as their differentiation into IFN-gamma- and IL-4-producing T cells in vitro.
Schellack
Carola
C
Intercell AG, Campus Vienna Biocenter 6, 1030 Wien, Austria.
Prinz
Karin
K
Egyed
Alena
A
Fritz
Jörg H
JH
Wittmann
Barbara
B
Ginzler
Michael
M
Swatosch
Gabriele
G
Zauner
Wolfgang
W
Kast
Constantia
C
Akira
Shizuo
S
von Gabain
Alexander
A
Buschle
Michael
M
Lingnau
Karen
K