title: Synthetic studies on (+)-ophiobolin A: asymmetric synthesis of the spirocyclic CD-ring moiety.
abstract: [reaction; see text] Asymmetric synthesis of the spirocyclic CD-ring moiety of (+)-ophiobolin A is described. Fragment A, which was prepared via pig liver esterase (PLE)-mediated kinetic resolution, and fragment B, which was prepared via diastereoselective allylation and subsequent kinetic iodolactonization, were coupled to afford the allylsilane 2, which was successfully cyclized to the desired spirocyclic CD-ring moiety 1a in the presence of a Lewis acid.
authors: Department of Chemistry, Faculty of Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan.
authors: Naoyoshi
authors: N
authors: Noguchi
authors: Masahisa
authors: M
authors: Nakada