title: Diffusion tensor imaging findings and their correlation with neuropsychological deficits in patients with temporal lobe epilepsy and interictal psychosis.
abstract: OBJECTIVE
  To examine frontotemporal white-matter integrity in patients with temporal lobe epilepsy (TLE) and interictal psychosis.
  
  
  METHODS
  Patients with TLE and interictal psychosis (IP; n = 20) were compared with age-matched TLE patients without psychosis (NIP; n = 20). Patients had either no focal lesions or hippocampal sclerosis on conventional MRI. Complete diffusion tensor imaging (DTI) data were available in 18 IP and 20 NIP patients. A region-of-interest (ROI) approach was used to determine the DTI measures, fractional anisotropy (FA) and mean diffusivity (MD), in the middle frontal and middle temporal gyri. The relation between the DTI measures and neuropsychological tests previously identified as impaired in the IP group was examined.
  
  
  RESULTS
  The IP group had significantly lower FA values in both frontal and temporal regions and significantly higher MD in bilateral frontal regions. We found that performance on some neuropsychological tests was significantly related to frontotemporal FA reductions.
  
  
  CONCLUSIONS
  Our findings suggest that subtle abnormalities in the frontotemporal white matter of patients with interictal psychosis may be undetectable on conventional MRI. These abnormalities may contribute to the cognitive deficits detected in these patients.
authors: Department of Experimental and Clinical Epilepsy, Institute of Neurology, London, United Kingdom.
authors: Dominique
authors: D
authors: Flügel
authors: Mara
authors: M
authors: Cercignani
authors: Mark R
authors: MR
authors: Symms
authors: Annette
authors: A
authors: O'Toole
authors: Pamela J
authors: PJ
authors: Thompson
authors: Matthias J
authors: MJ
authors: Koepp
authors: Jacqueline
authors: J
authors: Foong