Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline.
A systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-to-treat for extended-release stimulant preparations and atomoxetine (ATX). A panel of experts from several European countries used the review to make recommendations about the use of these drugs in practice, and conclusions are reported: (1) Long-acting preparations should be available and used; (2) They should not replace short-acting drugs (which will be the initial treatment for many children for reasons of cost and flexibility of dosing). Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made.
Banaschewski
Tobias
T
Dept. of Child & Adolescent Psychiatry/Psychotherapy, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany. tbanasc@gwdg.de
Coghill
David
D
Santosh
Paramala
P
Zuddas
Alessandro
A
Asherson
Philip
P
Buitelaar
Jan
J
Danckaerts
Marina
M
Döpfner
Manfred
M
Faraone
Stephen V
SV
Rothenberger
Aribert
A
Sergeant
Joseph
J
Steinhausen
Hans-Christoph
HC
Sonuga-Barke
Edmund J S
EJ
Taylor
Eric
E