title: Lethal photosensitization and guided bone regeneration in treatment of peri-implantitis: an experimental study in dogs.
abstract: The purpose of this study was to evaluate the effect of lethal photosensitization and guided bone regeneration (GBR) on the treatment of ligature-induced peri-implantitis in different implant surfaces. The treatment outcome was evaluated by clinical and histometric methods. A total of 40 dental implants with four different surface coatings (10 commercially pure titanium surface (cpTi); 10 titanium plasma-sprayed (TPS); 10 acid-etched surface; 10 surface-oxide sandblasted) were inserted into five mongrel dogs. After 3 months, the animals with ligature-induced peri-implantitis were subjected to surgical treatment using a split-mouth design. The controls were treated by debridment and GBR, while the test side received an additional therapy with photosensitization, using a GaAlAs diode laser, with a wavelength of 830 nm and a power output of 50 mW for 80 s (4 J/cm2), and sensitized toluidine blue O (100 microg/ml). The animals were sacrificed 5 months after therapy. The control sites presented an earlier exposition of the membranes on all coating surfaces, while the test group presented a higher bone height gain. Re-osseointegration ranged between 41.9% for the cpTi surface and 31.19% for the TPS surface in the test sites; however differences were not achieved between the surfaces. The lethal photosensitization associated with GBR allowed for better re-osseointegration at the area adjacent to the peri-implant defect regardless of the implant surface.
authors: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
authors: Jamil Awad
authors: JA
authors: Shibli
authors: Marilia Compagnoni
authors: MC
authors: Martins
authors: Fernando Salimon
authors: FS
authors: Ribeiro
authors: Valdir Gouveia
authors: VG
authors: Garcia
authors: Francisco Humberto
authors: FH
authors: Nociti
authors: Elcio
authors: E
authors: Marcantonio