Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras.
[structure: see text] A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.
Moggio
Loredana
L
Dipartimento di Scienze Ambientali, Seconda Università di Napoli, Caserta, Italy.
De Napoli
Lorenzo
L
Di Blasio
Benedetto
B
Di Fabio
Giovanni
G
D'Onofrio
Jennifer
J
Montesarchio
Daniela
D
Messere
Anna
A