title: Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.
abstract: A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the differentiation of isocephalomannine (2-debenzoylpaclitaxel-2-pentenoate) from cephalomannine and 7-epi-cephalomannine. A comparative study of the cephalomannine isomers was carried out using molecular ions (MS) and fragmentation patterns (MS/MS) for sub-structural analysis. An attempt has been made to identify isocephalomannine in Cremophor(R) EL formulations.
authors: Mass Spectrometry Laboratory, Dabur Research Foundation, 22 Site IV, Sahibabad, UP, 201010, India. vivekanandank@dabur.com
authors: Kannan
authors: K
authors: Vivekanandan
authors: Madugundu Guru
authors: MG
authors: Swamy
authors: Sudhanand
authors: S
authors: Prasad
authors: Rama
authors: R
authors: Mukherjee
authors: Anand C
authors: AC
authors: Burman