Grasp a pTyr-peptide by its SOCS.
Signaling via suppressors of cytokine signaling (SOCS) is an important negative feedback system for cytokine-mediated signal transduction. Recently in Molecular Cell, Babon et al. (2006) described the tertiary structure of SOCS3 in complex with a phosphotyrosine-containing peptide from the IL-6 receptor subunit gp130, and they identified the specific amino acids that are critical for binding.
Hirano
Toshio
T
Laboratory of Developmental Immunology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
Murakami
Masaaki
M