Standardization of microarray and pharmacogenomics data.
This chapter provides a bottom-up perspective on bioinformatics data standards, beginning with a historical perspective on biochemical nomenclature standards. Various file format standards were soon developed to convey increasingly complex and voluminous data that nomenclature alone could not effectively organize without additional structure and annotation. As areas of biochemistry and molecular biology have become more integral to the practice of modern medicine, broader data representation models have been created, from corepresentation of genomic and clinical data as a framework for drug research and discovery to the modeling of genotyping and pharmacogenomic therapy within the broader process of the delivery of health care.
Husser
Casey S
CS
Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Buchhalter
Jeffrey R
JR
Raffo
O Scott
OS
Shabo
Amnon
A
Brown
Steven H
SH
Lee
Karen E
KE
Elkin
Peter L
PL