Signal separation and determination of the enantiomeric purity of primary amines with (-)-myrtenal--a 13C NMR study.
The applicability of (-)-myrtenal as a chiral derivatizing agent in combination with (13)C NMR spectroscopy was investigated. (13)C NMR was found to be a valuable tool for the identification and enantiomer differentiation of primary amines including beta-amino alcohols and vicinal diamines. The enantiomeric excess could be determined via automated deconvolution and integration, and was found to be in good accordance with the expected values even in the cases, when enantiomer differentiation was not possible in (1)H NMR spectra.
Dufrasne
Francois
F
Laboratoire de Chimie Pharmaceutique Organique, Institut de Pharmacie, Université Libre de Bruxelles, CP 205/5, Campus Plaine, B-1050 Brussels, Belgium.
Gelbcke
Michael
M
Galanski
Mathea S
MS