Effect of nifedipine on cerebral saturation parameters.
The effect of 10 mg nifedipine on cerebral oxygenation was studied in healthy individuals. The duration of investigation was 30 min or 3 h. Nifedipine appreciably increased cerebral oxygenation (by 5.9%, p<0.01) against the background of significant increase in heart rate and negligible decrease in systolic arterial pressure. Drowsiness was the most serious side effect of nifedipine (observed in 52.8% examined subjects).
Sal'nikov
S N
SN
Central Clinical Hospital No. 1, Russian Railway Association, Moscow.