title: [Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group].
abstract: OBJECTIVE
  To search for new artemisinin derivatives with higher immunosuppressive activity.
  
  
  METHODS
  Two kinds of new artemisinin derivatives containing polyethylene glycol group were synthesized from dihydroartemisinin via condensation and esterification. These compounds were assayed for their inhibitory activity on ConA-induced T cell proliferation and LPS-induced B cell proliferation.
  
  
  RESULTS
  Twenty three new compounds (2a - 2f, 3a - 3d, 4a - 4f, 6a, 6b and 7a - 7g) were synthesized and identified by 1H NMR and elemental analysis.
  
  
  CONCLUSIONS
  These compounds had immunosuppressive activity in vitro. Among them, the symmetrical substituted compound 2 and 6 had higher activity than mono-substituted compound 3, 4 and 7. Especially, compounds 2a - 2f remarkably exhibited higher inhibition in comparison with artemisinin and artesunate.
authors: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Jian-Xin
authors: JX
authors: Zhang
authors: Jun-Xia
authors: JX
authors: Wang
authors: Yu
authors: Y
authors: Zhang
authors: Jian-Ping
authors: JP
authors: Zuo
authors: Jin-Ming
authors: JM
authors: Wu
authors: Yi
authors: Y
authors: Sui
authors: Ying
authors: Y
authors: Li