Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes.
Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.
Reed
Julie E
JE
Department of Chemistry, Imperial College London, South Kensington, UK.
Arnal
Anna Arola
AA
Neidle
Stephen
S
Vilar
Ramón
R