Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues.
[reaction: see text] Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A(2) derivatives (6a-6c) has been accomplished. (15S)-Prostaglandin-A(2) (1), from the gorgonian Plexaura homomalla, served as the starting material for the synthesis. The absolute configuration was determined using NMR.
Ratnayake
Anokha S
AS
Department of Medicinal Chemistry, University of Utah, Salt Lake City, 84112, USA.
Bugni
Tim S
TS
Veltri
Charles A
CA
Skalicky
Jack J
JJ
Ireland
Chris M
CM