Transcriptional regulation of the human pregnane-X receptor.
This review addresses the general structure and function of nuclear receptors and places specific emphasis on their role in xenosensing, resulting in the activation of a battery of genes mediating drug metabolism, conjugation, and transport. The pregnane-X receptor is a nuclear receptor that functions to control a battery of genes predominantly involved in drug metabolism and we place emphasis on how this important cellular mediator is transcriptionally activated. We have identified both positive and negative regulatory elements in the PXR promoter, the balance of which dictates the steady state expression of the PXR gene.
Gibson
G Gordon
GG
University of Surrey, School of Biomedical and Molecular Sciences, Molecular Toxicology Group, England. g.gibson@surrey.ac.uk
Phillips
Anna
A
Aouabdi
Sihem
S
Plant
Kate
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Plant
Nick
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