title: Macrocycloadditions leading to conformationally restricted small molecules.
abstract: [reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.
authors: Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02138, USA.
authors: Ryan E
authors: RE
authors: Looper
authors: Daniela
authors: D
authors: Pizzirani
authors: Stuart L
authors: SL
authors: Schreiber