title: Hybrid segmentation framework for tissue images containing gene expression data.
abstract: Associating specific gene activity with functional locations in the brain results in a greater understanding of the role of the gene. To perform such an association for the over 20,000 genes in the mammalian genome, reliable automated methods that characterize the distribution of gene expression in relation to a standard anatomical model are required. In this work, we propose a new automatic method that results in the segmentation of gene expression images into distinct anatomical regions in which the expression can be quantified and compared with other images. Our method utilizes shape models from training images, texture differentiation at region boundaries, and features of anatomical landmarks, to deform a subdivision mesh-based atlas to fit gene expression images. The subdivision mesh provides a common coordinate system for internal brain data through which gene expression patterns can be compared across images. The automated large-scale annotation will help scientists interpret gene expression patterns at cellular resolution more efficiently.
authors: Computational Biomedicine Lab, Dept. of Computer Science, University of Houston, Houston TX, USA.
authors: Musodiq
authors: M
authors: Bello
authors: Tao
authors: T
authors: Ju
authors: Joe
authors: J
authors: Warren
authors: James
authors: J
authors: Carson
authors: Wah
authors: W
authors: Chiu
authors: Christina
authors: C
authors: Thaller
authors: Gregor
authors: G
authors: Eichele
authors: Ioannis A
authors: IA
authors: Kakadiaris