title: 4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase.
abstract: 4'-Fluorinated analogue of 9-[(1'R,2'S,3'R)-2',3'-dihydroxy-cyclopentan-1'-yl]adenine (DHCaA) and their related analogues were systematically synthesized under the Mitsunobu and palladium(0) coupling conditions followed by fluorination with inversion of the configuration by using diethylaminosulfur trifluoride, respectively. 4'-beta-Fluoro DHCaA and 2-amino-4'-alpha-fluoro DHCaA demonstrated slight inhibitory activity against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase, respectively.
authors: Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan. kitade@biomol.gifu-u.ac.jp
authors: Yukio
authors: Y
authors: Kitade
authors: Takayuki
authors: T
authors: Ando
authors: Tsuyoshi
authors: T
authors: Yamaguchi
authors: Ayumi
authors: A
authors: Hori
authors: Masayuki
authors: M
authors: Nakanishi
authors: Yoshihito
authors: Y
authors: Ueno