Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.
Liu
Xuan
X
Beijing Institute of Biotechnology, Beijing 100850, China.
Huang
Wei
W
Li
Chufang
C
Li
Ping
P
Yuan
Jing
J
Li
Xiaorong
X
Qiu
Xiao-Bo
XB
Ma
Qingjun
Q
Cao
Cheng
C