title: Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH.
abstract: We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.
authors: Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital and 1st Faculty of Medicine of Charles University, Prague, Czech Republic. libuse.babicka@vfn.cz
authors: Libuse
authors: L
authors: Babicka
authors: Sarka
authors: S
authors: Ransdorfova
authors: Jana
authors: J
authors: Brezinova
authors: Zuzana
authors: Z
authors: Zemanova
authors: Lenka
authors: L
authors: Sindelarova
authors: Magda
authors: M
authors: Siskova
authors: Jacqueline
authors: J
authors: Maaloufova
authors: Jaroslav
authors: J
authors: Cermak
authors: Kyra
authors: K
authors: Michalova