Synthesis and cytotoxic activities of 8-alkyl or 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones.
A series of 8-alkyl- and 8-aryl-8,9-dihydro-7H-isoindolo[5,6- g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for their in vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).
Jung
Jae-Kyung
JK
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
Jung
Eun-Kyung
EK
Nam-Goong
Kwon
K
Cho
Jung-Sook
JS
Kim
Hwan-Mook
HM
Park
Sung-Gyu
SG
Yoo
Yeong-Ah
YA
Kwon
Joo-Hee
JH
Lee
Hee-Soon
HS