CAMTA in cardiac hypertrophy.
In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.
Schwartz
Robert J
RJ
The Institute of Biosciences and Technology, The Texas A&M University System Health Science Center, Houston, TX 77030, USA. rschwartz@ibt.tamhsc.edu
Schneider
Michael D
MD