title: A new class of silica cross-linked micellar core-shell nanoparticles.
abstract: Micellar nanoparticles made of surfactants and polymers have attracted wide attention in the materials and biomedical community for controlled drug delivery, molecular imaging, and sensing; however, their long-term stability remains a topic of intense study. Here we report a new class of robust, ultrafine silica core-shell nanoparticles formed from silica cross-linked, individual block copolymer micelles. Compared with pure polymeric micelles, the main advantage of the new core-shell nanoparticles is that they have significantly improved stability and do not break down during dilution. We also studied the drug loading and release properties of the silica cross-linked micellar particles, and we found that the new core-shell nanoparticles have a slower release rate which allows the entrapped molecules to be slowly released over a much longer period of time under the same experimental conditions. A range of functional groups can be easily incorporated through co-condensation with the silica matrix. The potential to deliver hydrophobic agents into cancer cells has been demonstrated. Because of their unique structures and properties, these novel core-shell nanoparticles could potentially provide a new nanomedicine platform for imaging, detection, and treatment, as well as novel colloidal particles and building blocks for mutlifunctional materials.
authors: Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors: Qisheng
authors: Q
authors: Huo
authors: Jun
authors: J
authors: Liu
authors: Li-Qiong
authors: LQ
authors: Wang
authors: Yingbing
authors: Y
authors: Jiang
authors: Timothy N
authors: TN
authors: Lambert
authors: Erica
authors: E
authors: Fang