title: Polysiphonia japonica extract suppresses the Wnt/beta-catenin pathway in colon cancer cells by activation of NF-kappaB.
abstract: Abnormal activation of the Wnt/beta-catenin pathway and subsequent up-regulation of beta-catenin response transcription (CRT) are associated with the development of colon cancer. Thus, the Wnt/beta-catenin pathway is an attractive target for chemoprevention and treatment of this cancer. We used a cell-based screen to identify a methanol extract of Polysiphonia japonica (EPJ) that suppresses the Wnt/beta-catenin pathway without altering the level of beta-catenin protein and reduces the expression of cyclin D1, which is a known beta-catenin/T cell factor (TCF)-dependent gene. EPJ inhibited the growth of various colon cancer cells. In addition, EPJ induced the nuclear translocation of nuclear factor-kappaB (NF-kappaB) in SW480 colon cancer cells. Our findings suggest that EPJ attenuates Wnt/beta-catenin signaling via activation of NF-kappaB and can potentially be used as a chemopreventive agent against colon cancer.
authors: PharmcoGenomic Research Center, Inje University, Busan, Korea.
authors: Jungsug
authors: J
authors: Gwak
authors: Seoyoung
authors: S
authors: Park
authors: Munji
authors: M
authors: Cho
authors: Taeyun
authors: T
authors: Song
authors: Seon-Heui
authors: SH
authors: Cha
authors: Dong-Eun
authors: DE
authors: Kim
authors: You-Jin
authors: YJ
authors: Jeon
authors: Jae-Gook
authors: JG
authors: Shin
authors: Sangtaek
authors: S
authors: Oh