title: The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.
abstract: We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.
authors: Department of Neuroscience and Neurology,University of Kuopio, Canthia, Kuopio, Finland. corina.pennanen@uku.fi
authors: Corina
authors: C
authors: Pennanen
authors: Cristina
authors: C
authors: Testa
authors: Marina
authors: M
authors: Boccardi
authors: Mikko P
authors: MP
authors: Laakso
authors: Merja
authors: M
authors: Hallikainen
authors: Eeva-Liisa
authors: EL
authors: Helkala
authors: Tuomo
authors: T
authors: Hänninen
authors: Miia
authors: M
authors: Kivipelto
authors: Mervi
authors: M
authors: Könönen
authors: Aulikki
authors: A
authors: Nissinen
authors: Susanna
authors: S
authors: Tervo
authors: Matti
authors: M
authors: Vanhanen
authors: Ritva
authors: R
authors: Vanninen
authors: Giovani B
authors: GB
authors: Frisoni
authors: Hilkka
authors: H
authors: Soininen