Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.
A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhasetrade mark Lanterns and evaluated in vitro for 5-HT(1A) receptor affinity. Biological screening, followed by a simple Fujita-Ban analysis, enabled the description of structure-activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.
Zajdel
Paweł
P
Laboratoire des Aminoacides, Peptides et Protéines, LAPP, UMR 5810, Faculté de Pharmacie, Université Montpellier I et II, 15 Avenue Charles Flahault, 34060 Montpellier, France. mfzajdel@cyf-kr.edu.pl
Subra
Gilles
G
Bojarski
Andrzej J
AJ
Duszyńska
Beata
B
Pawłowski
Maciej
M
Martinez
Jean
J