3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors.
The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.
McBride
Christopher M
CM
Small Molecule Drug Discovery, Medicinal Chemistry Department, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA.
Renhowe
Paul A
PA
Gesner
Thomas G
TG
Jansen
Johanna M
JM
Lin
Julie
J
Ma
Sylvia
S
Zhou
Yasheen
Y
Shafer
Cynthia M
CM