Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer.
The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.
Costa
Sandra
S
ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal. sandracostas@portugalmail.com
Pinto
Daniela
D
Pereira
Deolinda
D
Vasconcelos
André
A
Afonso-Lopes
Carlos
C
Osório
Teresa
T
Lopes
Carlos
C
Medeiros
Rui
R