The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma.
Immunohistochemically detected over-expression of P53-related protein (P53+++) and absence of P21(waf1) expression (P21-) correspond to loss of function of the P53-gene in diffuse large B-cell lymphoma (DLBCL) patients. Using immunohistochemistry we examined 80 patients with DLBCL and found that 23% had the P53+++/P21- phenotype while 51% had a germinal center (GC) pattern. Both the P53+++/P21- phenotype and the non-GC pattern were associated with inferior outcome. Notably, the prognostic power of the P53+++/P21- phenotype was restricted to patients with a GC pattern, without effect on outcome of patients with a non-GC phenotype. Our results show that immunohistochemistry can parallel gene expression profiling in addressing clinical variability of DLBCL patients.
Visco
Carlo
C
Department of Hematology, Ospedale S. Bortolo, Vicenza, Italy. carlovisco@hotmail.com
Canal
Fabio
F
Parolini
Claudia
C
Andreoli
Annalisa
A
Ambrosetti
Achille
A
Krampera
Mauro
M
Lestani
Maurizio
M
Pizzolo
Giovanni
G
Chilosi
Marco
M