title: Doppler ultrasound assessment of posterior tibial artery size in humans.
abstract: OBJECTIVE
  The difference between structural remodeling and changes in tone of peripheral arteries in the lower extremities has not been evaluated. The purpose of this study was to (1) evaluate the day-to-day reproducibility and interobserver reliability (IOR) of posterior tibial artery (PTA) diameter measurements and (2) evaluate the effect of posture on PTA diameter at rest (Drest), during 10 minutes of proximal cuff occlusion (Dmin), and after the release of cuff occlusion (Dmax), as well as range (Dmax - Dmin) and constriction [(Dmax - Drest)/(Dmax - Dmin) x 100] in vivo.
  
  
  METHODS
  We used B-mode sonography to image the PTA during each condition.
  
  
  RESULTS
  Day-to-day reliability was good for Drest (intraclass correlation coefficient [ICC] 0.95; mean difference 4.2%), Dmin (ICC 0.93; mean difference 5.4%), and Dmax (ICC 0.99; mean difference 2.2%). The coefficient of repeatability for IOR was 70.5 microm, with a mean interobserver error of 4.7 microm. The seated position decreased Drest (2.6 +/- 0.2 to 2.4 +/- 0.3 mm; p = 0.002), increased Dmin (2.1 +/- 0.2 to 2.4 +/- 0.2 mm; p = 0.001), and decreased Dmax (3.1 +/- 0.4 to 2.8 +/- 0.3 mm; p < 0.001) compared with the supine position. The seated position also decreased arterial range (Dmax - Dmin) from 0.9 +/- 0.2 to 0.5 +/- 0.1 mm (p = 0.003) and increased basal arterial constriction from 57 +/- 19% to 105 +/- 27% (p = 0.007).
  
  
  CONCLUSIONS
  The system employed for measuring PTA diameter yields unbiased and consistent estimates. Furthermore, lower extremity arterial constriction and range change with posture in a manner consistent with known changes in autonomic activity.
authors: Department of Exercise Science, University of Georgia, Athens, 30602, USA. msabat1@cellbio.emory.edu
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