title: Chk2 molecular interaction map and rationale for Chk2 inhibitors.
abstract: To organize the rapidly accumulating information on bioregulatory networks related to the histone gamma-H2AX-ATM-Chk2-p53-Mdm2 pathways in concise and unambiguous diagrams, we used the molecular interaction map notation (http://discover.nci.nih.gov/min). Molecular interaction maps are particularly useful for networks that include protein-protein binding and posttranslational modifications (e.g., phosphorylation). Both are important for nearly all of the proteins involved in DNA double-strand break signaling. Visualizing the regulatory circuits underlying cellular signaling may help identify key regulatory reactions and defects that can serve as targets for anticancer drugs.
authors: Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. pommier@nih.gov
authors: Yves
authors: Y
authors: Pommier
authors: John N
authors: JN
authors: Weinstein
authors: Mirit I
authors: MI
authors: Aladjem
authors: Kurt W
authors: KW
authors: Kohn