title: Optical recording-guided pacing to create functional line of block during ventricular fibrillation.
abstract: Low-energy defibrillation is very desirable in cardiac rhythm management. We previously reported that ventricular fibrillation (VF) can be synchronized with a novel synchronized pacing technique (SyncP) using low-energy pacing pulses. This study sought to create a line of block during VF using SyncP. SyncP was performed in six isolated rabbit hearts during VF using optical recording to control the delivery of pacing pulses in real time. Four pacing electrodes with interelectrode distances of 5 mm were configured in a line along and across the myocardial fiber direction. The electrodes were controlled independently (independent mode) or fired together (simultaneous mode). Significant wavefront synchronization was observed along the electrode line as indicated by a decrease in variance. With the independent SyncP protocol, the decrease in the variance was 19.3 and 13.7% (P<0.001) for the along-, and across-fiber configurations, respectively. With the simultaneous SyncP protocol, the variance was reduced by 24.2 and 10.7% (P<0.001) in the along- and across-fiber configurations. The effect of synchronization dropped off with distance from the line of pacing. We conclude that SyncP can effectively create a line of functional block that isolates regions of VF propagation. Further optimization of this technique may prove useful for low-energy ventricular defibrillation.
authors: Cedars-Sinai Medical Center, Department of Medicine, Division of Cardiology, Los Angeles, California 90048, USA.
authors: Krishna
authors: K
authors: Ravi
authors: Motoki
authors: M
authors: Nihei
authors: Anjuli
authors: A
authors: Willmer
authors: Hideki
authors: H
authors: Hayashi
authors: Shien-Fong
authors: SF
authors: Lin