title: Lessons learned from neutral ICD trials.
abstract: Multiple prospective randomized trials with implantable cardioverter defibrillators (ICDs) over the past decade have convincingly established the efficacy of ICD therapy in reducing all-cause mortality, by significantly reducing sudden cardiac death. Nevertheless, four trials have failed to show improved survival. Analysing these, in comparison with the positive trials, provides important information concerning the type of patients not likely to receive benefit from ICDs: (i) those with relatively low mortality (< or = 18% within 2 years of follow-up; (ii) those whose mechanism of death is predominantly non-arrhythmic; (iii) patients early (within 6 weeks) after infarction.
authors: Guidant Corporation, Park Lane, Culliganlaan 2B, 1831 Diegem, Brussels, Belgium. snisam@guidant.com
authors: Seah
authors: S
authors: Nisam
authors: Günter
authors: G
authors: Breithardt