title: [Comparative analysis of intimal hyperplasia after sirolimus-eluting stent and thin-strut bare-metal stent implantation in small coronary arteries].
abstract: OBJECTIVE
  This study aimed at evaluating reduction in intimal hyperplasia volume following angioplasty using sirolimus-eluting stents (Cypher) compared with thin-strut bare-metal stents (Pixel) in patients with small vessels.
  
  
  METHODS
  Eighty patients with coronary artery disease were prospectively included in two consecutive series, the first using sirolimus-eluting stents (50) and the second using bare-metal stents (30).
  
  
  RESULTS
  The use of sirolimus-eluting stents reduced: in-stent net volume obstruction [5.0% (SE = 0.77) x 39.0% (SE = 4.72), p < 0.001], in-stent late loss [0.25 mm (SE = 0.03) x 1,11 mm (SE = 0.13), p < 0.001], in-segment late loss [0.30 mm (SE = 0.04) x 0.83 mm (SE = 0.11), p < 0.001], in-stent restenosis (0% x 33.3%, p < 0.001) and in-segment restenosis (4% x 36.7%, p < 0.001). The event-free survival rate was 96% in the sirolimus-eluting stent group versus 86.7% in the bare-metal stent group (BMS) (p = 0.190).
  
  
  CONCLUSIONS
  Sirolimus-eluting stents are superior to thin-strut bare-metal stents in reducing intimal hyperplasia (less in-stent obstruction and less late lumen loss) in patients with small vessels. The use of these stents significantly reduced angiographic restenosis at eight months.
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP. fdevito@cardiol.br
authors: Fernando Stuchi
authors: FS
authors: Devito
authors: Amanda G M R
authors: AG
authors: Sousa
authors: Fausto
authors: F
authors: Feres
authors: Alexandre Antonio Cunha
authors: AA
authors: Abizaid
authors: Rodolfo
authors: R
authors: Staico
authors: Luis Alberto Piva
authors: LA
authors: Mattos
authors: Luis Fernando Leite
authors: LF
authors: Tanajura
authors: Andréa C L S
authors: AC
authors: Abizaid
authors: Aurea Jacob
authors: AJ
authors: Chaves
authors: J Eduardo M R
authors: JE
authors: Sousa