title: Morphology of the enteric nervous system in the hindgut of an infant with cloacal exstrophy.
abstract: The authors describe the morphology of the enteric nervous system in the hindgut of an infant with cloacal exstrophy. Cloacal exstrophy was diagnosed at 32 weeks' gestation using prenatal ultrasonography. The baby was delivered at 34 weeks' gestation and underwent a separation of the cecum from bladder halves, reapproximation of hemibladders, closure of the omphalocele and pubic symphysis, and a distal colostomy. Intestinal wall specimens were obtained at colostomy from the distal end of the rudimentary hindgut. Serial frozen sections were prepared for histochemical acetylcholinesterase staining. Histological investigations demonstrated a strikingly crowded, immature enteric ganglia and prominent bundles of wandering cholinergic nerves. These findings suggest the unique pathology of the enteric nervous system development in cloacal exstrophy, in which the rudimentary hindgut behaves as a blind alley of the migratory pathway for neural crest-derived cells during embryogenesis. Histological examinations of the hindgut enteric nervous system in cloacal exstrophy may be beneficial for evaluating the postnatal development of the distal colon which might be utilized for a pull-through procedure.
authors: Division of Surgery, Children's Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan. shimotake@ujitoku.or.jp
authors: T
authors: T
authors: Shimotake
authors: T
authors: T
authors: Tsuda
authors: S
authors: S
authors: Aoi
authors: H
authors: H
authors: Tomiyama
authors: N
authors: N
authors: Iwai