Enantio- and diastereocontrolled total synthesis of (+)-boronolide.
An efficient stereoselective total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless asymmetric hydroxylation, a chelation-controlled vinyl Grignard reaction followed by a Sharpless asymmetric epoxidation, hydrolytic kinetic resolution, and a ring-closing metathesis.
Kumar
Pradeep
P
Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India. pk.tripathi@ncl.res.in
Naidu
S Vasudeva
SV