3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity.
Jelley
Richard A
RA
Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. richard_jelly@yahoo.co.uk
Elliott
Jason
J
Gibson
Karl R
KR
Harrison
Timothy
T
Beher
Dirk
D
Clarke
Earl E
EE
Lewis
Huw D
HD
Shearman
Mark
M
Wrigley
Jonathan D J
JD