title: Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland.
abstract: Vanilloid receptor 1 (VR1) is a polymodal receptor originally found in sensory neurons of the central nervous system. Recent evidence indicates that VR1 is also expressed in non-neuronal tissues. We report here endogenous expression of VR1 in rabbit submandibular gland (SMG) and its possible role in regulating saliva secretion based on: (i) the expression of VR1 mRNA and protein detected in SMG; (ii) VR1 was mainly localized in the basolateral membrane of duct cells and the cytoplasm of acinar cells and also in cytoplasm of primary cultured neonatal rabbit SMG cells; (iii) stimulation of neonatal rabbit SMG cells with capsaicin induced a significant increase in intracellular calcium, and capsazepine, a VR1 antagonist, abolished this increase; (iv) infusion of capsaicin via the external carotid artery to isolated SMG increased saliva secretion of the gland. These findings indicated that VR1 was expressed in SMG and appeared to play an important role in regulating saliva secretion.
authors: Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China.
authors: Yan
authors: Y
authors: Zhang
authors: Bin
authors: B
authors: Xiang
authors: Yu-Ming
authors: YM
authors: Li
authors: Yun
authors: Y
authors: Wang
authors: Xian
authors: X
authors: Wang
authors: Yi-Ni
authors: YN
authors: Wang
authors: Li-Ling
authors: LL
authors: Wu
authors: Guang-Yan
authors: GY
authors: Yu