[Expression and significance of survivin protein, PTEN in prostatic cancer].
OBJECTIVE
To study the expressions of survivin, PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma (PCa).


METHODS
The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH).


RESULTS
The positive rate of survivin protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive.


CONCLUSIONS
The positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma (PCa). Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.
Xia
Xue-yan
XY
Department of Pathology, the First Affiliated Hospital, Dalian Medical University, Liaoning, China.
Li
Lian-hong
LH
Li
Xian-cheng
XC
Jang
Tao
T