title: Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.
abstract: A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhasetrade mark Lanterns and evaluated in vitro for 5-HT(1A) receptor affinity. Biological screening, followed by a simple Fujita-Ban analysis, enabled the description of structure-activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.
authors: Laboratoire des Aminoacides, Peptides et Protéines, LAPP, UMR 5810, Faculté de Pharmacie, Université Montpellier I et II, 15 Avenue Charles Flahault, 34060 Montpellier, France. mfzajdel@cyf-kr.edu.pl
authors: Paweł
authors: P
authors: Zajdel
authors: Gilles
authors: G
authors: Subra
authors: Andrzej J
authors: AJ
authors: Bojarski
authors: Beata
authors: B
authors: Duszyńska
authors: Maciej
authors: M
authors: Pawłowski
authors: Jean
authors: J
authors: Martinez