Use of an acute seroconversion panel to evaluate a third-generation enzyme-linked immunoassay for detection of human immunodeficiency virus-specific antibodies relative to multiple other assays.
A human immunodeficiency virus type 1 (HIV-1)/HIV-2 antibody screening assay, the Genetic Systems HIV-1/HIV-2 PLUS O EIA, was compared to several established screening or confirmatory tests using an acute HIV seroconversion panel. The HIV-1/HIV-2 PLUS O EIA showed an improved sensitivity over all tested antibody screening methods, and detected antibody in 7 of 19 specimens found to be negative by a first-generation EIA but positive for the presence of HIV RNA.
Louie
Brian
B
San Francisco Department of Public Health, 101 Grove St., Rm. 412, San Francisco, CA 94102, USA. brian.louie@sfdph.org
Pandori
Mark W
MW
Wong
Ernest
E
Klausner
Jeffrey D
JD
Liska
Sally
S