Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey.
OBJECTIVE
To compare peptic ulcer prevalence in patients referred for upper gastrointestinal endoscopy in two Italian hospitals in pre-Helicobacter era and ten years after the progressive diffusion of eradication therapy.


METHODS
We checked all the endoscopic examinations consecutively performed in the Gastroenterology Unit of Padova during 1986-1987 and 1995-1996, and in the Gastroenterology Unit of Parma during 1992 and 2002. Chi Square test was used for statistic analysis.


RESULTS
Data from both the endoscopic centers showed a statistically significant decrease in the prevalence of ulcers: from 12.7% to 6.3% (P<0.001) in Padova and from 15.6% to 12% (P<0.001) in Parma. The decrease was significant both for duodenal (from 8.8% to 4.8%, P<0.001) and gastric ulcer (3.9% to 1.5%, P<0.001) in Padova, and only for duodenal ulcer in Parma (9.2% to 6.1%, P<0.001; gastric ulcer: 6.3% to 5.8%, NS).


CONCLUSIONS
Ten years of extensive Helicobacter pylori (H pylori) eradication in symptomatic patients led to a significant reduction in peptic ulcer prevalence. This reduction was particularly evident in Padova, where a project for the sensibilization of H pylori eradication among general practioners was carried out between 1990 and 1992. Should our hypothesis be true, H pylori eradication might in the future lead to peptic ulcer as a rare endoscopic finding.
Nervi
Giorgio
G
Dipartimento di Scienze Cliniche, Sezione di Gastroenterologia, Azienda Ospedaliera Universitaria di Parma, v. Gramsci 14, 43100 Parma, Italy.
Liatopoulou
Stefania
S
Cavallaro
Lucas-Giovanni
LG
Gnocchi
Alessandro
A
Dal-Bo
Nadia
N
Rugge
Massimo
M
Iori
Veronica
V
Cavestro
Giulia-Martina
GM
Maino
Marta
M
Colla
Giancarlo
G
Franze
Angelo
A
Di Mario
Francesco
F