title: Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8.
abstract: In the present studies, we investigated the molecular mechanism of one of the active ingredients of Ginkgo biloba, EGb761, to affect the levels of several apoptotic markers in six brain regions following global ischemia in senescence-accelerated mice. A 4-day treatment with EGb761 significantly decreased bax/bcl-2 ratios in all brain regions in both young and aged mice. Our findings indicate that the bax/bcl-2 ratio provides a suitable index of apoptosis and modulation of these markers may explain the neuroprotective action of EGb761.
authors: Department of Neurosurgery, KunMing Medical College, KunMing, China.
authors: Gang
authors: G
authors: Lu
authors: Yan
authors: Y
authors: Wu
authors: Ying Tat
authors: YT
authors: Mak
authors: Sen Mun
authors: SM
authors: Wai
authors: Zhong Tang
authors: ZT
authors: Feng
authors: John A
authors: JA
authors: Rudd
authors: David Tai Wai
authors: DT
authors: Yew