title: Inferring transcriptional modules from ChIP-chip, motif and microarray data.
abstract: 'ReMoDiscovery' is an intuitive algorithm to correlate regulatory programs with regulators and corresponding motifs to a set of co-expressed genes. It exploits in a concurrent way three independent data sources: ChIP-chip data, motif information and gene expression profiles. When compared to published module discovery algorithms, ReMoDiscovery is fast and easily tunable. We evaluated our method on yeast data, where it was shown to generate biologically meaningful findings and allowed the prediction of potential novel roles of transcriptional regulators.
authors: BIOI@SCD, Department of Electrical Engineering, KU Leuven, Kasteelpark Arenberg, B-3001 Heverlee, Belgium.
authors: Karen
authors: K
authors: Lemmens
authors: Thomas
authors: T
authors: Dhollander
authors: Tijl
authors: T
authors: De Bie
authors: Pieter
authors: P
authors: Monsieurs
authors: Kristof
authors: K
authors: Engelen
authors: Bart
authors: B
authors: Smets
authors: Joris
authors: J
authors: Winderickx
authors: Bart
authors: B
authors: De Moor
authors: Kathleen
authors: K
authors: Marchal