title: Plasma and liver hepatitis C virus variability in patients coinfected with human immunodeficiency virus.
abstract: Liver and plasma hepatitis C virus (HCV) variability was compared by E2 cloning and sequencing in three patients coinfected with HCV and human immunodeficiency virus (HIV) before and after interferon treatment and in three patients solely infected with HCV. The plasma and liver samples contained unique sequences. In the patients coinfected with HIV, accumulated random mutations produced mostly nonsynonymous substitutions in contrast to the reduced HCV genetic variability seen after treatment.
authors: Laboratoire de Virologie EA2968, Universite Victor Segalen Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux, France.
authors: Anne-Christine
authors: AC
authors: Jouvencel
authors: Didier
authors: D
authors: Neau
authors: Muriel
authors: M
authors: Faure
authors: Martine
authors: M
authors: Neau
authors: Christophe
authors: C
authors: Martinaud
authors: Elisabeth
authors: E
authors: Legrand
authors: Pascale
authors: P
authors: Trimoulet
authors: Isabelle
authors: I
authors: Garrigue
authors: Brigitte
authors: B
authors: Le Bail
authors: Paulette
authors: P
authors: Bioulac-Sage
authors: Michel
authors: M
authors: Dupon
authors: Jean-Marie
authors: JM
authors: Ragnaud
authors: Herve
authors: H
authors: Fleury
authors: Marie-Edith
authors: ME
authors: Lafon