title: Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.
abstract: Immunodominance has been well-demonstrated in many antiviral and antibacterial systems, but much less so in the setting of immune responses against cancer. Tumor Ag-specific CD8+ T cells keep cancer cells in check via immunosurveillance and shape tumor development through immunoediting. Because most tumor Ags are self Ags, the breadth and depth of antitumor immune responses have not been well-appreciated. To design and develop antitumor vaccines, it is important to understand the immunodominance hierarchy and its underlying mechanisms, and to identify the most immunodominant tumor Ag-specific T cells. We have comprehensively analyzed spontaneous cellular immune responses of one individual and show that multiple tumor Ags are targeted by the patient's immune system, especially the "cancer-testis" tumor Ag NY-ESO-1. The pattern of anti-NY-ESO-1 T cell responses in this patient closely resembles the classical broad yet hierarchical antiviral immunity and was confirmed in a second subject.
authors: Ludwig Institute for Cancer Research, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.
authors: Heather
authors: H
authors: Jackson
authors: Nektaria
authors: N
authors: Dimopoulos
authors: Nicole A
authors: NA
authors: Mifsud
authors: Tsin Yee
authors: TY
authors: Tai
authors: Qiyuan
authors: Q
authors: Chen
authors: Suzanne
authors: S
authors: Svobodova
authors: Judy
authors: J
authors: Browning
authors: Immanuel
authors: I
authors: Luescher
authors: Lisa
authors: L
authors: Stockert
authors: Lloyd J
authors: LJ
authors: Old
authors: Ian D
authors: ID
authors: Davis
authors: Jonathan
authors: J
authors: Cebon
authors: Weisan
authors: W
authors: Chen