Rhodium-catalyzed asymmetric cyclization/hydroboration of 1,6-enynes.
[reaction: see text] Reaction of enyne 1 with catecholborane catalyzed by a 1:1 mixture of [Rh(COD)(2)](+)SbF(6)(-) and (S)-BINAP (5 mol %) followed by Pd-catalyzed arylation with p-IC(6)H(4)CF(3) gave benzylidenecyclopentane 5 in 65% yield with 88% ee. Rhodium-catalyzed asymmetric cyclization/hydroboration followed either by Pd-catalyzed arylation or by oxidation was applied to the synthesis of a number of chiral, nonracemic carbocycles and heterocycles.
Kinder
Robert E
RE
PM Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, USA.
Widenhoefer
Ross A
RA