Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think.
Prostaglandins (PGs), small lipid molecules derived from arachidonic acid by COX enzymes, are critical mediators of allergic inflammation. Our understanding of the role of PGs in allergic lung inflammation has been hampered by the very short biologic half-life of these mediators, which has made mechanistic studies difficult in human subjects. However, advances in molecular biology and pharmacology have given investigators the opportunity to examine the role of specific prostanoids in the development of allergic inflammation in animal models. Studies investigating specific PG receptors are also elucidating the mechanisms by which PGs regulate the pulmonary allergic phenotype. This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation.
Moore
Martin L
ML
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Peebles
R Stokes
RS