title: Asymmetric reduction of oxime ethers promoted by chiral spiroborate esters with an O3BN framework.
abstract: Enatioselective reduction of oxime ethers promoted by chiral spiroborate esters with an O3BN framework is reported for the first time. In the presence of (R,S)-1, 11 aralkyloxime ethers are reduced by borane-THF at 0-5 degrees C to give (S)-1-aralkylamine in high yield and excellent enatiomeric excess (up to 98% ee). Influence of reaction conditions on the enantioselectivity of the reduction is investigated, and a possible mechanism of the catalytic reduction is suggested.
authors: Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors: Yunbo
authors: Y
authors: Chu
authors: Zixing
authors: Z
authors: Shan
authors: Dejun
authors: D
authors: Liu
authors: Nannan
authors: N
authors: Sun