Mitochondria in Parkinson disease: back in fashion with a little help from genetics.
Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hope for disease-modifying therapies in Parkinson disease.
Muqit
Miratul M K
MM
Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, England.
Gandhi
Sonia
S
Wood
Nicholas W
NW