title: Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction.
abstract: Multicomponent reactions (MCRs) and microwave-assisted organic synthesis (MAOS) have been used as key methods for the synthesis of fused dihydropyrimidine derivatives. The three-component condensation of 3-amino-5-alkylthio-1,2,4-triazoles with aromatic aldehydes and acetoacetamides under microwave irradiation was developed as a rapid and efficient solution-phase method for the high-yielding preparation of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxamide libraries. In addition, the selective reduction of the formed dihydrotriazolopyrimidines to trans-trans-2-alkylthio-7-aryl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxamides was established. The described synthetic protocols provide rapid access to novel and diversely substituted dihydroazolopyrimidine libraries.
authors: Department of Chemistry of Heterocyclic Compounds, State Scientific Institution Institute for Single Crystals of National Academy of Sciences of Ukraine, Kharkiv. chebanov@isc.kharkov.com
authors: Valentin A
authors: VA
authors: Chebanov
authors: Elena A
authors: EA
authors: Muravyova
authors: Sergey M
authors: SM
authors: Desenko
authors: Vladimir I
authors: VI
authors: Musatov
authors: Irina V
authors: IV
authors: Knyazeva
authors: Svetlana V
authors: SV
authors: Shishkina
authors: Oleg V
authors: OV
authors: Shishkin
authors: C Oliver
authors: CO
authors: Kappe