Solitary eyelid Kaposi sarcoma in an HIV-negative patient.
OBJECTIVE
To describe a case of localized Kaposi sarcoma (KS) of the eyelid in an HIV-seronegative patient.


METHODS
An 80-year-old man developed an ulcerated nodular tumor-like mass that grew rapidly on his left upper eyelid. There were no similar lesions elsewhere. The eyelid lesion was completely excised and histopathologically examined. Serological analyses and molecular biologic techniques, including polymerase chain reaction, were used.


RESULTS
Laboratory examinations were within normal limits, and serology for HIV was negative. Histological sections revealed a vascular proliferation composed predominantly of small slit-like blood vessels and epithelioid spindle cells, supporting the diagnosis of KS. Polymerase chain reaction was positive for human herpesvirus 8. During a 2-year follow-up, no recurrences, development of new lesions, or HIV seroconversions were observed.


CONCLUSIONS
This is a classic KS involving only the eyelid in an HIV-negative patient. Location in the eyelid is a possible, albeit rare, initial solitary manifestation of KS in elderly HIV-negative patients. Surgery is both safe and effective.
Dammacco
Rosanna
R
Department of Ophthalmology and Otorhinolaryngology, University of Bari Medical School, Bari, Italy. rdammacco@libero.it
Lapenna
Lucia
L
Giancipoli
Giovanni
G
Piscitelli
Domenico
D
Sborgia
Carlo
C