title: Multivalent RGD synthetic peptides as potent alphaVbeta3 integrin ligands.
abstract: We study herein the multivalency effect of a cluster of alphaVbeta3-ligands held on a cyclodecapeptide template. An array of RAFT(c[-RGDfK-])n derivatives containing from one to sixteen clustered RGD motifs were synthesized and comparatively assayed in vitro on alphaVbeta3-expressing cells. Efficient inhibition of the alphaVbeta3-specific 23C6 monoclonal antibody fixation was observed with ligands displaying three and four copies of the cyclo[-RGDfK-] peptide.
authors: Ingénierie Moléculaire et Chimie Bioorganique, LEDSS, CNRS UMR 5616, ICMG FR 2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France.
authors: Elisabeth
authors: E
authors: Garanger
authors: Didier
authors: D
authors: Boturyn
authors: Jean-Luc
authors: JL
authors: Coll
authors: Marie-Christine
authors: MC
authors: Favrot
authors: Pascal
authors: P
authors: Dumy