title: Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.
abstract: Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
authors: Department of Physics, IBILCE/UNESP, São José do Rio Preto-SP, Brazil.
authors: Mário T
authors: MT
authors: Murakami
authors: Cristiane C
authors: CC
authors: Melo
authors: Yamileth
authors: Y
authors: Angulo
authors: Bruno
authors: B
authors: Lomonte
authors: Raghuvir K
authors: RK
authors: Arni