Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones.
[reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.
Hosseini
Masood
M
Medicinal Chemistry Research, Novo Nordisk A/S, Måløv, Denmark.
Kringelum
Henriette
H
Murray
Anthony
A
Tønder
Janne E
JE