title: Energetics of the Na(+) pump in the heart.
abstract: Movement of ions across the cell membrane is driven by the free energy released from ATP hydrolysis. Here we will briefly review the chemistry of Na(+), K(+)-ATPase reaction; we will also review some recent results defining the relationship between the energetic driving force and Na(+) efflux by the Na(+) pump in the normal myocardium and then discuss this relationship for pathophysiologic states in the heart.
authors: NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. jingwall@rics.bwh.harvard.edu
authors: Joanne S
authors: JS
authors: Ingwall
authors: James A
authors: JA
authors: Balschi