title: p53 protein and bcl-2 expression in glioblastomas. Pathological correlations in a comprehensive series.
abstract: p53 and bcl-2 are two well-known antiapoptotic factors associated with gliomas, and mostly astrocytic tumors. In the present study we assessed, by immunohistochemistry, the expression of these two factors in a series of 50 glioblastomas. The correlations between their expression and several tumor-related factors (age, location, recurrence, proliferating potential) were investigated. Our results suggest that a valuable correlation between these factors cannot be found. This is in discrepancy with some literature data, which emphasize strong relations of p53 and bcl-2 in oncogenesis spreading or final prognosis. Further studies are needed, with unique, standard procedures for these evaluations.
authors: Immunohistochemistry Department, Victor Babes National Institute of Pathology, Bucharest, Romania. carmena@vbabes.ro
authors: Carmen
authors: C
authors: Ardeleanu
authors: M
authors: M
authors: Ceauşu
authors: Georgeta
authors: G
authors: Butur
authors: Zenaida Florea
authors: ZF
authors: Grămadă
authors: L
authors: L
authors: Dănăilă
authors: Fl
authors: F
authors: Hălălău
authors: D
authors: D
authors: Arsene