title: The inhibition of calcium carbonate crystal growth by the cysteine-rich Mdm2 peptide.
abstract: The crystal growth of calcite, the most stable calcium carbonate polymorph, in the presence of the cysteine-rich Mdm2 peptide (containing 48 amino acids in the ring finger configuration), has been investigated by the constant composition technique. Crystallization took place exclusively on well-characterized calcite crystals in solutions supersaturated only with respect to this calcium carbonate salt. The kinetic results indicated a surface diffusion spiral growth mechanism. The presence of the Mdm2 peptide inhibited the crystal growth of calcite by 22-58% in the concentration range tested, through adsorption onto the active growth sites of the calcite crystal surface. The kinetic results favored a Langmuir-type adsorption model, and the value of the calculated affinity constant was k(aff)=147x10(4) dm(3)mol(-1), a(ads)=0.29.
authors: Department of Chemistry, University of Patras, GR-26504 Patras, Greece. vdal@chemistry.upatras.gr
authors: E
authors: E
authors: Dalas
authors: A
authors: A
authors: Chalias
authors: D
authors: D
authors: Gatos
authors: K
authors: K
authors: Barlos