Progression to dementia in clinical subtypes of mild cognitive impairment.
OBJECTIVE
To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI).


METHODS
A follow-up examination (average follow-up period: 3.49 +/- 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline.


RESULTS
8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia. The clinical type of MCI is significantly associated with the likelihood of conversion to dementia.


CONCLUSIONS
When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia.
Alexopoulos
P
P
Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany. palexopoulos@freemail.gr
Grimmer
T
T
Perneczky
R
R
Domes
G
G
Kurz
A
A