Microwave-assisted preparation of fused bicyclic heteroaryl boronates: application in one-pot Suzuki couplings.
The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the tolerance of the boronic ester functional group to a variety of reaction conditions and the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse compound libraries.
DiMauro
Erin F
EF
Department of Chemistry Research and Discovery, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA. erin.dimauro@amgen.com
Vitullo
Jason R
JR