title: Preparation of annulated nitrogen-containing heterocycles via a one-pot palladium-catalyzed alkylation/direct arylation sequence.
abstract: [reaction: see text] A palladium-catalyzed/norbornene-mediated sequential coupling reaction involving an aromatic sp(2) C-H functionalization as the key step is described, in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one pot. A variety of highly substituted six- and seven-membered annulated pyrroles and pyrazoles were synthesized in a one-step process in good yields from readily accessible N-bromoalkyl pyrroles or pyrazoles and aryl iodides.
authors: Davenport Laboratories, Chemistry Department, University of Toronto, Ontario, Canada.
authors: Christophe
authors: C
authors: Blaszykowski
authors: Evangelos
authors: E
authors: Aktoudianakis
authors: Cyril
authors: C
authors: Bressy
authors: Dino
authors: D
authors: Alberico
authors: Mark
authors: M
authors: Lautens