A case of protein-losing enteropathy treated with methotrexate in a dog.
A 9-year-old female Pug was presented to us with chronic diarrhea. Hematologic findings indicated severe hypoproteinemia and hypoalbuminemia, and endoscopy revealed severe edema of the duodenal mucosa. Based on these results and on additional histopathological findings, we made a diagnosis of protein-losing enteropathy caused by lymphocytic-plasmacytic enteritis with lymphangiectasia. The dog was initially treated with prednisolone and cyclosporine. This treatment regimen was not effective. However, when methotrexate was substituted for cyclosporine, progress was obtained and the diagnosis was confirmed.
Yuki
Masashi
M
Yuki Animal Hospital, Nagoya, Aichi, Japan.
Sugimoto
Noriko
N
Takahashi
Kuniaki
K
Otsuka
Hiromi
H
Nishii
Naohito
N
Suzuki
Kiyomi
K
Yamagami
Tetsushi
T
Ito
Hiroshi
H