title: Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template.
abstract: The HCV NS3 protease is essential for replication of the hepatitis C virus (HCV) and therefore constitutes a promising new drug target for anti-HCV therapy. Several potent and promising HCV NS3 protease inhibitors, some of which display low nanomolar activities, were identified from a series of novel inhibitors incorporating a trisubstituted cyclopentane dicarboxylic acid moiety as a surrogate for the widely used N-acyl-(4R)-hydroxyproline in the P2 position.
authors: Department of Chemistry, Linköping University, S-581 83 Linköping, Sweden.
authors: Per-Ola
authors: PO
authors: Johansson
authors: Marcus
authors: M
authors: Bäck
authors: Ingemar
authors: I
authors: Kvarnström
authors: Katarina
authors: K
authors: Jansson
authors: Lotta
authors: L
authors: Vrang
authors: Elizabeth
authors: E
authors: Hamelink
authors: Anders
authors: A
authors: Hallberg
authors: Asa
authors: A
authors: Rosenquist
authors: Bertil
authors: B
authors: Samuelsson