title: Increased seizure duration in mice lacking aquaporin-4 water channels.
abstract: Aquaporins are intrinsic membrane proteins involved in water transport in fluid-transporting tissues. In the brain, aquaporin-4 (AQP4) is expressed widely by glial cells, but its function is unclear. Extensive basic and clinical studies indicate that osmolarity affects seizure susceptibility, and in our previous studies we found that AQP4 -/- mice have an elevated seizure threshold in response to the chemoconvulsant pentylenetetrazol. In this study, we examined the seizure phenotype of AQP4 -/- mice in greater detail using in vivo electroencephalographic recording. AQP4 -/- mice were found to have dramatically longer stimulation-evoked seizures following hippocampal stimulation as well as a higher seizure threshold. These results implicate AQP4 in water and potassium regulation associated with neuronal activity and seizures.
authors: Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
authors: D K
authors: DK
authors: Binder
authors: X
authors: X
authors: Yao
authors: A S
authors: AS
authors: Verkman
authors: G T
authors: GT
authors: Manley