title: No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus.
abstract: Prolonged over-exposure of rats to corticosterone attenuates 5-HT(1A)-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT(1A) receptor expression. We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.
authors: Swammerdam Institute for Life Sciences, Center for NeuroScience University of Amsterdam Kruislaan 320, 1098 SM Amsterdam, The Netherlands. nvgemert@science.uva.nl
authors: Neeltje G
authors: NG
authors: van Gemert
authors: Els
authors: E
authors: van Riel
authors: Onno C
authors: OC
authors: Meijer
authors: Susanne
authors: S
authors: Fehr
authors: Melitta
authors: M
authors: Schachner
authors: Marian
authors: M
authors: Joëls