title: [Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs].
abstract: OBJECTIVE
  To prepare the breviscapine liposomes and study the pharmacokinetics of breviscapine liposomes in Beagle dogs.
  
  
  METHODS
  The cross-over design (two periods) was employed. Six Beagle dogs were administrated a single intravenous dosage of 28 mg of breviscapine liposomes and reference preparation, respectively, scutellarin in plasma of 6 dogs at different sampling time was determined by RP-HPLC. The pharmacokinetic parameters were calculated by 3P97 program and compared by statistic analysis.
  
  
  RESULTS
  The mean concentration-time curves of breviscapine liposomes and reference preparation were both fitted to two-compartment model with the main pharmacokinetic parameters as follows: T 1/2 alpha were (4.4 +/- 0.7) min and (1.8 +/- 1.3) min respectively; T 1/2 beta were (55 +/- 27) min and (28 +/- 23) min respectively; V(c) were (1 580 +/- 265) mL and (2 460 +/- 2 200) mL respectively; CL(s) were (88 +/- 10) mL x min(-1) and (324 +/- 69) mL x min(-1) respectively; and AUC(0-720) were (363 +/- 42) microg x min x mL(-1) and (102 +/- 19) microg x min x mL(-1) respectively. The T 1/2 alpha, CL(s) and AUC(0-720) of breviscapine liposomes all had significant difference from those of reference preparation, after the data were examined by a one-way analysis of variance (ANOVA).
  
  
  CONCLUSIONS
  Compared with the reference preparation, breviscapine liposomes had a much more higher concentration in plasma and contained characteristic of sustained-release, which ameliorated the pharmacokinetic properties of scutellarin.
authors: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors: Wen-Li
authors: WL
authors: Lo
authors: Jian-Xin
authors: JX
authors: Guo
authors: Qi-Neng
authors: QN
authors: Ping
authors: Jin
authors: J
authors: Li
authors: Chu-Wei
authors: CW
authors: Zhao
authors: Lan
authors: L
authors: Zhang