title: A qualitative study of amlodipine and its related compounds by electrospray ionization tandem mass spectrometry.
abstract: A comprehensive structural analysis of amlodipine and certain related compounds was performed by electrospray ionization tandem mass spectrometry. Triple quadrupole and quadrupole time-of-flight instruments were used to provide collision-induced dissociation and accurate mass measurement for selected product and second-generation product ions. A unique ion rearrangement was observed, which was found to be characteristic of certain dihydropyridines. This study provides a fundamental understanding of the fragmentation of these compounds. The structural elucidation of an unknown impurity is presented as an example.
authors: Genpharm Inc., 85 Advance Road, Etobicoke, Ontario, Canada. johng@genpharm.ca
authors: John
authors: J
authors: Gibbons
authors: Jonathan
authors: J
authors: Pugh
authors: Gina
authors: G
authors: Dimopoulos-Italiano
authors: Richard
authors: R
authors: Pike