The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.
We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.
Pennanen
Corina
C
Department of Neuroscience and Neurology,University of Kuopio, Canthia, Kuopio, Finland. corina.pennanen@uku.fi
Testa
Cristina
C
Boccardi
Marina
M
Laakso
Mikko P
MP
Hallikainen
Merja
M
Helkala
Eeva-Liisa
EL
Hänninen
Tuomo
T
Kivipelto
Miia
M
Könönen
Mervi
M
Nissinen
Aulikki
A
Tervo
Susanna
S
Vanhanen
Matti
M
Vanninen
Ritva
R
Frisoni
Giovani B
GB
Soininen
Hilkka
H