Brief communication: ramipril markedly improves walking ability in patients with peripheral arterial disease: a randomized trial.
BACKGROUND
Peripheral arterial disease (PAD) affects up to 12% of adults older than 50 years of age. Conventional therapies have only modest effects in improving symptoms.


OBJECTIVE
To examine the effects of angiotensin-converting enzyme inhibition on walking ability in patients with PAD.


METHODS
Randomized, double-blind, placebo-controlled trial initiated in March 2003 and completed in January 2005.


METHODS
The Alfred Hospital, Melbourne, Australia.


METHODS
40 older adults with symptomatic PAD and no history of diabetes or hypertension.


METHODS
10 mg of ramipril (n = 20) or placebo (n = 20) once daily for 24 weeks. All patients completed the trial.


METHODS
Pain-free and maximum walking time were recorded during a standard treadmill test, and the standard Walking Impairment Questionnaire was administered.


RESULTS
After adjustment for the baseline pain-free walking time, mean pain-free walking time after ramipril treatment was 227 seconds (95% CI, 175 seconds to 278 seconds; P < 0.001) longer than that after placebo treatment. Similarly, maximum walking time improved by 451 seconds in the ramipril group (CI, 367 seconds to 536 seconds; P < 0.001) but did not change in the placebo group. Ramipril improved the Walking Impairment Questionnaire median distance score from 5% (range, 1% to 39%) to 21% (range, 12% to 58%; P < 0.001), speed score from 3% (range, 3% to 39%) to 18% (range, 8% to 50%; P < 0.001), and stair-climbing score from 17% (range, 4% to 80%) to 67% (range, 38% to 88%; P < 0.001). No adverse events were reported.


CONCLUSIONS
The sample size is modest, and the strict inclusion criteria limit the applicability of the results to patients with claudication and infrainguinal disease and those without diabetes.


CONCLUSIONS
Ramipril improved pain-free and maximum walking time in some adults with symptomatic PAD.
Ahimastos
Anna A
AA
Baker Heart Research Institute, Alfred Hospital, and Monash University, Melbourne, Victoria, Australia.
Lawler
Adam
A
Reid
Christopher M
CM
Blombery
Peter A
PA
Kingwell
Bronwyn A
BA