title: Estimating health risk from exposure to 1,4-dioxane in Japan.
abstract: Exposure to 1,4-dioxane from the atmosphere around high-emission plants and from consumer products used in daily life that contain the substance may have adverse health effects; however, its emission into the atmosphere is not regulated. In this study, the health risk posed by 1,4-dioxane is assessed to investigate whether measures should be undertaken to reduce exposure to 1,4-dioxane. The notion of the margin of exposure (MOE), given by the ratio of no observed adverse effect level (NOAEL) to actual or projected exposure level, is used to assess risk. In exposure assessment, two types of exposure channel are considered: (a) the use of consumer products that contain 1,4-dioxane and (b) the inhalation of air around high-emission plants. To estimate exposure via channel (a), we measured the concentration of 1,4-dioxane in consumer products and estimated the interindividual variability of exposure by Monte Carlo simulation that reflects the measured data. To estimate exposure via channel (b), we employed a local-level atmospheric dispersion model to estimate the concentration of 1,4-dioxane immediately around high-emission plants. For hazard assessment, we derived the inhalatory and oral NOAELs for liver adenomas and carcinomas and the uncertainty factor. The results suggest that measures are not needed to reduce exposure to 1,4-dioxane from consumer products. As for inhalation exposure around high-emission plants, some residents may be exposed to health risks if certain conservative analytical conditions are assumed. Even in this case, we conclude that it is not necessary for Plant A to stop the use of 1,4-dioxane immediately and that medium- to long-term emission reduction measures should be sufficient.
authors: Research Center for Chemical Risk Management, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan. ryoji-makino@aist.go.jp
authors: Ryoji
authors: R
authors: Makino
authors: Hajime
authors: H
authors: Kawasaki
authors: Atsuo
authors: A
authors: Kishimoto
authors: Masashi
authors: M
authors: Gamo
authors: Junko
authors: J
authors: Nakanishi