title: Role of caveolin-1 in the regulation of the vascular shear stress response.
abstract: In blood vessels, endothelia are submitted to constant shear effects and are, under normal conditions, capable of responding to any variation in hemodynamic forces. Caveolae - 50- to 100-nm plasma membrane invaginations present at the surface of terminally differentiated cells and particularly enriched in ECs - are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1). Previous studies have suggested that caveolae and endothelial Cav-1 may regulate the vascular response to altered shear stress. In this issue of the JCI, Yu et al. have examined the role of Cav-1/caveolae in the regulation of flow-induced alterations (i.e., mechanotransduction) in vessels from wild-type mice, Cav-1-deficient mice, and Cav-1-deficient mice re-expressing Cav-1 only in ECs. Their data suggest that caveolae/Cav-1 may act as sensors of altered shear stress and that they also organize the signaling response in stimulated ECs (see the related article beginning on page 1284).
authors: Department of Urology and the Albert Einstein Diabetes Research and Training Center (DRTC), Albert Einstein College of Medicine, New York, New York, USA. philippe.frank@jefferson.edu
authors: Philippe G
authors: PG
authors: Frank
authors: Michael P
authors: MP
authors: Lisanti