title: Hydrodynamic narrowing of tubes extruded from cells.
abstract: We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L(1/3), which is consistent with reported experimental data for various types of cells.
authors: Laboratoire Physicochimie Curie, Institut Curie/Centre National de la Recherche Scientifique, Unité Mixte de Recherche 168, 11, rue Pierre et Marie Curie, 75231 Paris Cedex 5, France. francoise.brochard-wyart@curie.fr
authors: F
authors: F
authors: Brochard-Wyart
authors: N
authors: N
authors: Borghi
authors: D
authors: D
authors: Cuvelier
authors: P
authors: P
authors: Nassoy