title: A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage.
abstract: In the present review we discuss a central role for substance P (SP) in carcinogenesis. We suggest that one mechanism to induce mitogenesis of tumor cells is the activation of neurokinin-1 receptor (NK1R) through SP, linking cancer promotion and progression to a neurokinin-mediated environment. After reviewing the role of both SP and its receptor NK1R in normal and neoplastic cells we propose the use of neurokinin-1 receptor antagonists as a novel and promising approach for treating patients with cancer.
authors: Hospital Universitario Virgen del Rocío de Sevilla, Universidad de Sevilla, Spain. festebano@ya.com
authors: F
authors: F
authors: Esteban
authors: M
authors: M
authors: Muñoz
authors: M A
authors: MA
authors: González-Moles
authors: M
authors: M
authors: Rosso