title: Intravascular ultrasound predictors of angiographic restenosis after sirolimus-eluting stent implantation.
abstract: OBJECTIVE
  In many countries, drug-eluting stent implantation is the dominant interventional strategy. We evaluated the clinical, angiographic, procedural, and intravascular ultrasound (IVUS) predictors of angiographic restenosis after sirolimus-eluting stent (SES) implantation.
  
  
  RESULTS
  SES implantation was successfully performed in 550 patients with 670 native coronary lesions. Six-month follow-up angiography was performed in 449 patients (81.6%) with 543 lesions (81.1%). Clinical, angiographic, procedural, and IVUS predictors of restenosis were determined. Using multivariable logistic regression analysis, the only independent predictors of angiographic restenosis were post-procedural final minimum stent area by IVUS [odds ratio (OR)=0.586, 95% confidence interval (CI) 0.387-0.888, P=0.012] and IVUS-measured stent length (OR=1.029, 95% CI 1.002-1.056, P=0.035). Final minimum stent area by IVUS and IVUS-measured stent length that best separated restenosis from non-restenosis were 5.5 mm2 and 40 mm, respectively. Lesions with final minimum stent area<5.5 mm2 and stent length>40 mm had the highest rate of angiographic restenosis [17.7% (11/62)], P<0.001 compared with other groups.
  
  
  CONCLUSIONS
  Independent predictors of angiographic restenosis after SES implantation were post-procedural final minimum stent area by IVUS and IVUS-measured stent length. The angiographic restenosis rate was highest in lesions with stent area<5.5 mm2 and stent length>40 mm.
authors: Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, 138-736, Korea.
authors: Myeong-Ki
authors: MK
authors: Hong
authors: Gary S
authors: GS
authors: Mintz
authors: Cheol Whan
authors: CW
authors: Lee
authors: Duk-Woo
authors: DW
authors: Park
authors: Bong-Ryong
authors: BR
authors: Choi
authors: Kyoung-Ha
authors: KH
authors: Park
authors: Young-Hak
authors: YH
authors: Kim
authors: Sang-Sig
authors: SS
authors: Cheong
authors: Jae-Kwan
authors: JK
authors: Song
authors: Jae-Joong
authors: JJ
authors: Kim
authors: Seong-Wook
authors: SW
authors: Park
authors: Seung-Jung
authors: SJ
authors: Park