New antimycobacterial S-alkylisothiosemicarbazones.
In connection with a systematic study of antimycobacterial agents against potentially pathogenic strains the series of 12 S-alkylisothiosemicarbazones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. Quinoline-4-carbaldehyde-S-hexyl-isothiohydrazone was found to be more active against potentially pathogenic strains than isoniazide.
Waisser
K
K
Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Hradec Králové, Czechia. waisser@faf.cuni.cz
Heinisch
L
L
Slosárek
M
M
Janota
J
J