Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline.
[reaction; see text] The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center.
Trost
Barry M
BM
Department of Chemistry, Stanford University, California 94305, USA. bmtrost@stanford.edu
Brennan
Megan K
MK