title: Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent.
abstract: The interaction of GnRH with its cognate receptor (GnRHR) in pituitary gonadotropes includes activation of Gq/G11 and phospholipase Cbeta (PLCbeta), which generates the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which are required for Ca2+ mobilization and PKC isoforms activation. Activation of PKC in pituitary gonadotropes leads to the activation of the major members of the mitogen-activated protein kinase superfamily (MAPK), namely: extracellular signal-regulated kinase (ERK), jun-N-terminal Kinase (JNK) and p38MAPK. The above pathways mediate GnRH-induced gonadotropin release and synthesis. Here we summarise the diverse mechanisms utilized by GnRH to activate the MAPK members and show that they depend on "cell-context".
authors: Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel.
authors: Masha
authors: M
authors: Dobkin-Bekman
authors: Michal
authors: M
authors: Naidich
authors: Adam J
authors: AJ
authors: Pawson
authors: Robert P
authors: RP
authors: Millar
authors: Rony
authors: R
authors: Seger
authors: Zvi
authors: Z
authors: Naor