title: [Weekly administration regimen of paclitaxel (PTX) in patient with inoperable or recurrent gastric cancer].
abstract: Paclitaxel is one of the new drugs against advanced/recurrent gastric cancer. We report its efficacy and toxicity with weekly administration for advanced/recurrent gastric cancer. We administered 26 patients (postoperative/non-operation=9/17) PTX 80 mg/m(2)by 1-hour intravenous infusion once a week for 3 weeks followed by one week rest. Median PTX administrations were 2.0 cycles (range:1-22). Characteristics of the patients were median age of 62 (range: 37-78) and PS 0/1/2:2/17/7, male/female:18/8. Over grade 3 toxicities did not occur. The overall response rate was 14.3%, and the non-PD rate was 66.8%. Median time to treatment failure was 61 days and median survival time was 221 days. These results suggest that weekly PTX has modest activity with a favorable toxicity profile in patients with advanced/recurrent gastric cancer, and so this regimen may thus might be recommended in an outpatient treatment setting.
authors: Second Dept. of Internal Medicine, Osaka Medical College.
authors: Takayuki
authors: T
authors: Kii
authors: Hiroya
authors: H
authors: Takiuchi
authors: Masahiro
authors: M
authors: Gotoh
authors: Shinichiro
authors: S
authors: Kawabe
authors: Shunsuke
authors: S
authors: Ohta
authors: Toshimitsu
authors: T
authors: Tanaka
authors: Shin
authors: S
authors: Kuwakado
authors: Hitoshi
authors: H
authors: Nishitani
authors: Ken-ichi
authors: K
authors: Katsu