Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.
Fosmidomycin is a promising antimalarial drug candidate with a unique chemical structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analogue FR900098 have been synthesized and their in vitro antimalarial activity versus the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined.
Kurz
Thomas
T
Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, D-20146 Hamburg, Germany. kurz@chemie.uni-hamburg.de
Schlüter
Katrin
K
Kaula
Uwe
U
Bergmann
Bärbel
B
Walter
Rolf D
RD
Geffken
Detlef
D