Plasma and liver hepatitis C virus variability in patients coinfected with human immunodeficiency virus.
Liver and plasma hepatitis C virus (HCV) variability was compared by E2 cloning and sequencing in three patients coinfected with HCV and human immunodeficiency virus (HIV) before and after interferon treatment and in three patients solely infected with HCV. The plasma and liver samples contained unique sequences. In the patients coinfected with HIV, accumulated random mutations produced mostly nonsynonymous substitutions in contrast to the reduced HCV genetic variability seen after treatment.
Jouvencel
Anne-Christine
AC
Laboratoire de Virologie EA2968, Universite Victor Segalen Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Neau
Didier
D
Faure
Muriel
M
Neau
Martine
M
Martinaud
Christophe
C
Legrand
Elisabeth
E
Trimoulet
Pascale
P
Garrigue
Isabelle
I
Le Bail
Brigitte
B
Bioulac-Sage
Paulette
P
Dupon
Michel
M
Ragnaud
Jean-Marie
JM
Fleury
Herve
H
Lafon
Marie-Edith
ME