title: Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones.
abstract: [reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.
authors: Medicinal Chemistry Research, Novo Nordisk A/S, Måløv, Denmark.
authors: Masood
authors: M
authors: Hosseini
authors: Henriette
authors: H
authors: Kringelum
authors: Anthony
authors: A
authors: Murray
authors: Janne E
authors: JE
authors: Tønder