Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.
Nzila
Alexis M
AM
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Wellcome Trust Research Laboratories, PO Box 43640, Nairobi, Kenya. anzila@wtnairobi.mimcom.net
Kokwaro
Gilbert
G
Winstanley
Peter A
PA
Marsh
Kevin
K
Ward
Steve A
SA