title: The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction.
abstract: A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.
authors: Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
authors: L
authors: L
authors: Wang
authors: L
authors: L
authors: Shan
authors: J
authors: J
authors: Yin
authors: M
authors: M
authors: Zhao
authors: D
authors: D
authors: Su
authors: J
authors: J
authors: Zhong