title: IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.
abstract: IC31, the combination of a novel immunostimulatory oligodeoxynucleotide containing deoxy-Inosine/deoxy-Cytosine (ODN1a) and the antimicrobial peptide KLKL(5)KLK, represents a promising novel adjuvant signaling via the TLR9/MyD88-dependent pathway of the innate immune system. In mice, IC31 induces potent peptide-specific type 1 cellular immune responses, as well as mainly type 1 dominated protein-specific cellular and humoral immune responses. In addition, cytotoxic T lymphocytes were induced, able to kill efficiently target cells in vivo. Activation of murine dendritic cells by IC31 induced efficiently proliferation of naïve CD4(+) TCR transgenic T cells (DO.11.10) as well as their differentiation into IFN-gamma- and IL-4-producing T cells in vitro.
authors: Intercell AG, Campus Vienna Biocenter 6, 1030 Wien, Austria.
authors: Carola
authors: C
authors: Schellack
authors: Karin
authors: K
authors: Prinz
authors: Alena
authors: A
authors: Egyed
authors: Jörg H
authors: JH
authors: Fritz
authors: Barbara
authors: B
authors: Wittmann
authors: Michael
authors: M
authors: Ginzler
authors: Gabriele
authors: G
authors: Swatosch
authors: Wolfgang
authors: W
authors: Zauner
authors: Constantia
authors: C
authors: Kast
authors: Shizuo
authors: S
authors: Akira
authors: Alexander
authors: A
authors: von Gabain
authors: Michael
authors: M
authors: Buschle
authors: Karen
authors: K
authors: Lingnau