title: Protective effect of reamberin on functional activity of mitochondria during skin ischemia.
abstract: Reamberin in a dose of 25 mg/kg (succinate concentration) was injected intravenously for 3 days starting from the 1st hour after skin ischemia modeling. This treatment decreased activities of lactate dehydrogenase, aspartate transaminase, and creatine phosphokinase in skin homogenates by 1.6 times, 19%, and 51.3%, respectively. The index of cytolysis decreased by 18%. Reamberin had an energotropic effect, which manifested in an increase in the total ATP content and concentration of creatine phosphate (by 16 and 10%, respectively). After administration of Reamberin, activity of the succinate-ubiquinone reductase system increased by 17%. Under these conditions succinate dehydrogenase activity exceeded the normal by 21%. Reamberin had no effect on the mitochondrial NADH-ubiquinone reductase system in dermal cells during skin ischemia. Superoxide dismutase activity in the area of necrosis increased to the control level on day 3 of treatment with Reamberin. Activities of catalase and glutathione peroxidase increased by 13 and 19%, respectively. Our results indicate that the course of intravenous treatment with Reamberin for 3 days contributes to an increase in reserve capacities of the antioxidant protection system and produces a protective effect during skin ischemia.
authors: Krasnodar Branch, Southern Bureau of the Russian Academy of Medical Sciences.
authors: V P
authors: VP
authors: Galenko-Yaroshevskii
authors: A V
authors: AV
authors: Agadzhanova
authors: K O
authors: KO
authors: Fedorovich
authors: N V
authors: NV
authors: Lapina
authors: A S
authors: AS
authors: Gorelashvili
authors: T M
authors: TM
authors: Berberashvili
authors: G V
authors: GV
authors: Sukoyan