title: Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabry's cardiomyopathy.
abstract: The present study evaluated the evolution of cardiac morphology, function, and late enhancement as a noninvasive marker of myocardial fibrosis, and their inter-relation during enzyme replacement therapy in patients with Fabry's disease using magnetic resonance imaging and color Doppler myocardial imaging. Late enhancement, which was present in up to 50% of patients, was associated with increased left ventricular mass, the failure of a significant regression of hypertrophy during enzyme replacement therapy, and worse segmental myocardial function. Late enhancement may predict the effect of enzyme replacement therapy on left ventricular mass and cardiac function.
authors: Institut für Röntgendiagnostik, Würzburg, Germany. beer@roentgen.uni-wuerzburg.de
authors: Meinrad
authors: M
authors: Beer
authors: Frank
authors: F
authors: Weidemann
authors: Frank
authors: F
authors: Breunig
authors: Anita
authors: A
authors: Knoll
authors: Sabrina
authors: S
authors: Koeppe
authors: Wolfram
authors: W
authors: Machann
authors: Dietbert
authors: D
authors: Hahn
authors: Christoph
authors: C
authors: Wanner
authors: Jörg
authors: J
authors: Strotmann
authors: Jörn
authors: J
authors: Sandstede