title: [Multi-center clinical study of acticoat (nanocrystalline silver dressing) for the management of residual burn wounds].
abstract: OBJECTIVE
  To investigate the clinical efficacy and safety of Acticoat (nanocrystalline silver dressing) for the treatment of residual burn wounds.
  
  
  METHODS
  Ninety-eight patients with 166 residual burn wounds were enrolled in the multi-center randomized clinical trials. In addition to the routine treatment, Acticoat was applied onto the wounds of the trial group once a day if there was much exudation from the wound, or the dressing change was made every other two days when the wounds were clean. Silver sulfadiazine (SD-Ag) was used in the control group of patients. The healing time was observed up to 20 days. The healing rate on the 15th day after treatment was taken as the percentage of healing.
  
  
  RESULTS
  The average healing time was (12 +/- 5) days after the application of Acticoat, which was significantly shorter than that in control wounds with SD-Ag (16 +/- 6) days, (P = 0.005 < 0.01). The total effective rate of the wounds for trial was 97.05%, which was higher than that in control (94.17%) group, but there was no statistically significant difference. The bacterial clearing rate of the Acticoat group on the 6th and 12th post treatment day was 21.7% and 43.5% respectively, which was significantly higher than that in control group. No side-effect was observed in the two groups during the study.
  
  
  CONCLUSIONS
  Acticoat with nanocrystalline silver can promote the healing of residual burn wounds effectively.
authors: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, PR China.
authors: Xiao-lu
authors: XL
authors: Li
authors: Yue-sheng
authors: YS
authors: Huang
authors: Yi-zhi
authors: YZ
authors: Peng
authors: Zhen-jiang
authors: ZJ
authors: Liao
authors: Guo-an
authors: GA
authors: Zhang
authors: Qun
authors: Q
authors: Liu
authors: Jin
authors: J
authors: Tang
authors: Xu-sheng
authors: XS
authors: Liu
authors: Qi-zhi
authors: QZ
authors: Luo