Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.
New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
Wiethe
Robert W
RW
Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA.
Stewart
Eugene L
EL
Drewry
David H
DH
Gray
David W
DW
Mehbob
Abdul
A
Hoekstra
William J
WJ