title: Comparison of ultrasound and electromagnetic field effects on osteoblast growth.
abstract: This study compares the mechanisms of ultrasound (US) on osteoblast proliferation with those of pulsed electromagnetic field (PEMF), by different signal transduction pathway inhibitors. The cells were stimulated for 15 min under US or for 2 h under PEMF exposure. Twenty-four h after the beginning of stimulation, the cells were harvested and used for mitochondrial activity test (MTT) analysis. The results showed that there are different transduction pathways for US and PEMF stimulation that lead to an upgrade of osteoblast proliferation, although their pathways all lead to an increase in cytocolic Ca2+ and activation of calmodulin. These findings offer a biochemical mechanism to support the process of ultrasound and PEMF-induced enhanced healing of bone fractures.
authors: Center for Nano Bioengineering, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China.
authors: Jimmy Kuan-Jung
authors: JK
authors: Li
authors: James Cheng-An
authors: JC
authors: Lin
authors: Hwa-Chang
authors: HC
authors: Liu
authors: Jui-Sheng
authors: JS
authors: Sun
authors: Rouh-Chyu
authors: RC
authors: Ruaan
authors: Chung
authors: C
authors: Shih
authors: Walter Hong-Shong
authors: WH
authors: Chang