Perspectives on blockade of TGFbeta overexpression.
Many approaches to blocking profibrotic TGFbeta overexpression are under way. Therapeutic targeting of TGFbeta-Smad signaling holds promise for slowing or halting progressive renal disease. In this issue, Fukasawa et al., using the unilateral ureteral obstruction model, provide a new target for therapeutic intervention by identifying loss of the Smad corepressors Ski and SnoN as a mechanism that amplifies the profibrotic actions of TGFbeta.
Huang
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Y
Fibrosis Research Laboratory, Division of Nephrology, University of Utah School of Medicine, Salt Lake City, 84108, USA.
Border
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WA
Noble
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NA