title: Novel class of cyclophosphamide prodrug: cyclophosphamide spiropiperaziniums (CPSP).
abstract: A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure-activity relationships were revealed.
authors: School of Pharmaceutical Science, Peking University, Beijing 100083, PR China.
authors: Qi
authors: Q
authors: Sun
authors: Run-Tao
authors: RT
authors: Li
authors: Wei
authors: W
authors: Guo
authors: Jing-Rong
authors: JR
authors: Cui
authors: Tie-Ming
authors: TM
authors: Cheng
authors: Ze-Mei
authors: ZM
authors: Ge