title: Intracranial pressure monitoring: modeling cerebrovascular pressure transmission.
abstract: OBJECTIVE
  To examine changes in cerebrovascular pressure transmission derived from arterial blood pressure (ABP) and intracranial pressure (ICP) recordings by autoregressive moving average modeling technique.
  
  
  METHODS
  Digitized ICP and ABP recordings were obtained from patients with brain injury. Two groups were defined: Group A with 4 patients who demonstrated plateau waves, and Group B with 4 intracranial hypertensive, hypoperfused patients. For each 16.5 s interval, mean values of ICP, ABP, cerebral perfusion pressure (CPP), and corresponding highest modal frequency (HMF) of cerebrovascular pressure transmission were computed.
  
  
  RESULTS
  Mean values of CPP and HMF of 56.2 mmHg and 2.0 Hz for Group A were significantly higher (p < 0.005) than corresponding mean values of 31.9 mmHg and 0.744 Hz for Group B. The mean value of the slope of the regression line between HMF and CPP for group A of -0.034 Hz/mmHg was significantly different (p < 0.025) than the mean value of 0.0077 Hz/mmHg for Group B. Computations of HMF, pressure reactivity, and correlation pressure reactivity index on continuous pressure recordings are illustrated.
  
  
  CONCLUSIONS
  Values of HMF of cerebrovascular pressure transmission are inversely related to CPP when pressure regulation is thought to be intact, and directly related when regulation is likely lost.
authors: Department of Electrical and Computer Engineering, University of Memphis, Memphis, Tennessee 38152-3180, USA. mdaley@memphis.edu
authors: M L
authors: ML
authors: Daley
authors: C W
authors: CW
authors: Leffler
authors: M
authors: M
authors: Czosnyka
authors: J D
authors: JD
authors: Pickard