Regulation of TRPV5 and TRPV6 by associated proteins.
The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.
van de Graaf
Stan F J
SF
Department of Physiology, Radboud Univ. Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Hoenderop
Joost G J
JG
Bindels
René J M
RJ