Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord.
Oligodendrocytes and their precursors serve critical roles in the maintenance of neurological function. Although activity of the transcription factors (TFs) Olig1, Olig2, Sox10, and Nkx2.2 is required during early oligodendrocyte development, their later expression in adult central nervous system is rather poorly characterized. Here we have analyzed co-expression patterns of these transcriptional proteins in the mouse cervical spinal cord. Our findings indicate that TF co-expression patterns describe heterogeneity in adult oligodendroglial populations (1) in distinct sub-regions of grey and white matter and (2) with respect to level of maturation from proliferating precursors to myelinating oligodendrocytes. Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia.
Kitada
Masaaki
M
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Rowitch
David H
DH