title: Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes.
abstract: Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.
authors: Department of Chemistry, Imperial College London, South Kensington, UK.
authors: Julie E
authors: JE
authors: Reed
authors: Anna Arola
authors: AA
authors: Arnal
authors: Stephen
authors: S
authors: Neidle
authors: Ramón
authors: R
authors: Vilar