Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel gamma-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure-activity relationship studies of these compounds were also developed.
Takahashi
Yasuko
Y
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
Fuwa
Haruhiko
H
Kaneko
Akane
A
Sasaki
Makoto
M
Yokoshima
Satoshi
S
Koizumi
Hifumi
H
Takebe
Tohru
T
Kan
Toshiyuki
T
Iwatsubo
Takeshi
T
Tomita
Taisuke
T
Natsugari
Hideaki
H
Fukuyama
Tohru
T