Imidazolinones: potent inhibitors of acetohydroxyacid synthase.
The imidazolinones, a new chemical class of herbicides, were shown to be uncompetitive inhibitors of acetohydroxyacid synthase from corn. This is the first common enzyme in the biosynthetic pathway for valine, leucine, and isoleucine. The K(i) for the imidazolinones tested ranged from 2 to 12 micromolar. These results may explain the mechanism of action of these new herbicides.
Shaner
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American Cyanamid Company, P. O. Box 400, Princeton, New Jersey 08540.
Anderson
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Stidham
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