title: Cyclobutane derivatives as potent NK1 selective antagonists.
abstract: A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki <or=1 nM), and potent inhibition of central NK1 receptor following oral administration. Syntheses of these compounds are also described herein.
authors: Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
authors: Michelle Laci
authors: ML
authors: Wrobleski
authors: Gregory A
authors: GA
authors: Reichard
authors: Sunil
authors: S
authors: Paliwal
authors: Sapna
authors: S
authors: Shah
authors: Hon-Chung
authors: HC
authors: Tsui
authors: Ruth A
authors: RA
authors: Duffy
authors: Jean E
authors: JE
authors: Lachowicz
authors: Cynthia A
authors: CA
authors: Morgan
authors: Geoffrey B
authors: GB
authors: Varty
authors: Neng-Yang
authors: NY
authors: Shih