Effect of 80 mg/day simvastatin therapy on cardiovascular outcomes in adults with versus without metabolic syndrome.
It is not known whether high-dose statins can reduce the excess burden (and consequent adverse cardiovascular outcomes) of coronary artery disease in patients with metabolic syndrome compared with those without metabolic syndrome. The results of our study suggest that high-dose simvastatin may be required to reduce excess events in very high-risk cohorts with metabolic syndrome.
Kamalesh
Masoor
M
Indiana University School of Medicine and affiliated Veterans Affairs Medical Center, Indianapolis, Indiana, USA. Masoor.kamalesh@med.Va.gov
Rao
Roopa
R
Sawada
Stephen
S
Friend
Amy
A
Schellhase
Ellen
E
Evans
Tamara
T