title: [Comparison of ramosetron and azasetron for prevention of acute and delayed cisplatin-induced emesis in lung cancer patients].
abstract: We performed a retrospective study that compared the efficacy and safety of ramosetron with azasetron in a case of acute and delayed emesis induced by cisplatin (CDDP)-included chemotherapy in patients with lung cancer. The study subjects were 100 lung cancer patients treated with combination therapy of cisplatin, ifosfamide, irinotecan (CIC therapy). The ramosetron group and azasetron group received, respectively, ramosetron 0.3 mg or azasetron 10 mg intravenous injection, 30 minutes prior to CDDP. All patients received 32 mg of dexamethasone intravenously. Protection from emesis showed no significant difference between two treatment groups. However, the grade of nausea was significantly lower in the ramosetron group than in the azasetron group. Furthermore, chlorpromazine hydrochloride for use as a rescue medication was required by significantly fewer in the ramosetron group than in the azasetron group. Adverse effects were observed in 27 cases in the ramosetron group and 24 cases in the azasetron group. However, because the symptoms were all mild, we did not consider there was any safety problem. In conclusion, it was suggested that ramosetron is a clinically useful treatment for acute and delayed emesis induced by cisplatin-induced chemotherapy in patients with lung cancer.
authors: Dept. of Pharmacology and Therapeutics, Hokkaido Pharmaceutical University School of Pharmacy.
authors: Toru
authors: T
authors: Hayakawa
authors: Mayumi
authors: M
authors: Sato
authors: Masako
authors: M
authors: Konaka
authors: Azusa
authors: A
authors: Makino
authors: Tae
authors: T
authors: Hirohata
authors: Sawako
authors: S
authors: Totsu
authors: Yoshiko
authors: Y
authors: Wada
authors: Hideki
authors: H
authors: Sato
authors: Nobuo
authors: N
authors: Inotsume
authors: Akihisa
authors: A
authors: Fujita
authors: Kyu-ichiro
authors: K
authors: Sekine