title: Chiral silanes via asymmetric hydrosilylation with catalytic CuH.
abstract: [reaction: see text] CuH-catalyzed asymmetric conjugate reduction of beta-silyl-alpha,beta-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)(2) leads to highly enantioselective 1,4-reductions.
authors: Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, USA. lipshutz@chem.ucsb.edu
authors: Bruce H
authors: BH
authors: Lipshutz
authors: Naoki
authors: N
authors: Tanaka
authors: Benjamin R
authors: BR
authors: Taft
authors: Ching-Tien
authors: CT
authors: Lee