title: Synthesis and receptor binding evaluation of clavizepine analogues with no ring D substituents.
abstract: Assembly of the azepine ring of xantheno[9,1-cd]azepines by electrophilic cyclization of sulfonamide acetals provides access to clavizepine analogues in the form of 2,12b-dihydro- or 4-hydroxy-2,3,4,12b-tetrahydro-1H-xantheno[9,1-cd]azepines, in the latter case producing the trans derivative stereoselectively. Binding assays for clavizepine and analogues at adrenergic, dopaminergic, and serotonergic receptors are reported.
authors: Departamento de Química Organica y Unidad Asociada al CSIC, Facultad de Química, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors: M Carmen
authors: MC
authors: de la Fuente
authors: Shirley E
authors: SE
authors: Pullan
authors: Ilse
authors: I
authors: Biesmans
authors: Domingo
authors: D
authors: Domínguez