title: Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
abstract: We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
authors: Julius-Maximilians-Universität Würzburg, Medizinische Klinik II, 97070 Würzburg, Germany. loeffler_j@klinik.uni-wuerzburg.de
authors: Juergen
authors: J
authors: Loeffler
authors: Michael
authors: M
authors: Steffens
authors: Eva-Maria
authors: EM
authors: Arlt
authors: Mohammad-Reza
authors: MR
authors: Toliat
authors: Markus
authors: M
authors: Mezger
authors: Anita
authors: A
authors: Suk
authors: Thomas F
authors: TF
authors: Wienker
authors: Holger
authors: H
authors: Hebart
authors: Peter
authors: P
authors: Nürnberg
authors: Michael
authors: M
authors: Boeckh
authors: Per
authors: P
authors: Ljungman
authors: Rudolf
authors: R
authors: Trenschel
authors: Hermann
authors: H
authors: Einsele