title: Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product (AGE)-induced C-reactive protein expression in hepatoma cells by suppressing Rac-1 activation.
abstract: Serum levels of advanced glycation end products (AGEs) are associated with an acute phase reactant, C-reactive proteins (CRP) in diabetic patients. However, whether AGEs could directly stimulate hepatic CRP production remains to be elucidated. We found here that AGEs upregulated CRP mRNA levels in cultured Hep3B cells via Rac-1 activation, which was blocked by pigment epithelium-derived factor (PEDF). Our present study suggests that AGEs are one of the potent inducers of CRP and that PEDF may work as an anti-inflammatory agent against AGEs in the liver.
authors: Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Takafumi
authors: T
authors: Yoshida
authors: Sho-ichi
authors: S
authors: Yamagishi
authors: Kazuo
authors: K
authors: Nakamura
authors: Takanori
authors: T
authors: Matsui
authors: Tsutomu
authors: T
authors: Imaizumi
authors: Masayoshi
authors: M
authors: Takeuchi
authors: Takato
authors: T
authors: Ueno
authors: Michio
authors: M
authors: Sata