title: Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1.
abstract: Hypoxia-inducible factor-1 (HIF-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. We found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced HIF-1alpha protein levels in HepG2 hepatocellular carcinoma cells. Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor. Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1alpha and VEGF expression in vascular endothelial cells. These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1alpha-mediated angiogenesis.
authors: College of Dentistry, Pusan National University, Busan 602-739, Korea.
authors: Moon-Kyoung
authors: MK
authors: Bae
authors: Se-Hee
authors: SH
authors: Kim
authors: Joo-Won
authors: JW
authors: Jeong
authors: You Mie
authors: YM
authors: Lee
authors: Hae-Sun
authors: HS
authors: Kim
authors: Su-Ryun
authors: SR
authors: Kim
authors: Il
authors: I
authors: Yun
authors: Soo-Kyung
authors: SK
authors: Bae
authors: Kyu-Won
authors: KW
authors: Kim