title: Radioguided surgery using intravenous 99mTc sestamibi associated with breast magnetic resonance imaging for guidance of breast cancer resection.
abstract: The purpose of this study was to evaluate the feasibility of surgery radioguided with intravenous (99m)Tc sestamibi associated with magnetic resonance imaging (MRI) of the breast to detect tumor extent and guide complete tumor resection. A descriptive experimental study was developed with 10 breast cancer patients (stage IIA-IIB) who underwent mastectomy. From 2 to 10 days before surgery, the patients underwent breast MRI with 0.1 mmol/kg of gadolinium and scintimammography with a 740 MBq of (99m)Tc sestamibi. A region of interest was drawn around the tumor image and an uptake curve as a function of time was plotted to calculate the optimal time to perform radioguided surgery. In the perioperative period, the same dose of (99m)Tc sestamibi was intravenously injected into the patients. Tumor resection was performed under the guidance of a gamma probe. MRI was used to evaluate the skin and deep fascia involvement and to detect occult tumor foci which were also excised. Subsequently a modified radical mastectomy was performed. Tumor and residual breast were histopathologically examined. In a series of 10 women, all demonstrated (99m)Tc sestamibi uptake in tumor cells. Eight patients showed no disease in the residual breast, one presented with one foci of invasive ductal carcinoma measuring 0.5 cm in diameter located 5 cm from the tumor bed, and one presented with one foci of ductal carcinoma in situ measuring 0.8 cm at the resection margin. The mean tumor size in the histopathologic assessment was 3.3 cm and in MRI was 5.0 cm. Radioguided surgery using (99m)Tc sestamibi associated with MRI is a feasible technique that can be employed in tumor resection.
authors: Department of Gynecology, Division of Oncology and Senology, State University of Campinas, Sao Paulo, Brazil. giuliano.duarte@ig.com.br
authors: Giuliano Mendes
authors: GM
authors: Duarte
authors: César Cabello
authors: CC
authors: dos Santos
authors: Renato Zocchio
authors: RZ
authors: Torresan
authors: Marcelo
authors: M
authors: Alvarenga
authors: Gilliat H Q
authors: GH
authors: Telles
authors: Susana Trigo
authors: ST
authors: Bianchessi
authors: Nelson
authors: N
authors: Caserta
authors: Silmara R
authors: SR
authors: Segala
authors: Mariana da Cunha
authors: Mda C
authors: Lopes de Lima
authors: Elba Cristina Sá
authors: EC
authors: de Camargo Etchebehere
authors: Edwaldo E
authors: EE
authors: Camargo