title: Low-grade gliomas -- current concepts.
abstract: Diffuse astrocytomas, oligodendrogliomas, and oligoastrocytomas (mixed gliomas) WHO grade II, pleomorphic xanthoastrocytomas (PXAs), pilocytic astrocytomas, and subependymal giant cell astrocytomas (SEGAs) are often referred to as low-grade gliomas. WHO grade II astrocytomas, oligodendrogliomas, and mixed gliomas are characterized by their infiltrative growth, frequent tumor recurrence and a more than 50 % risk for malignant progression. In contrast, pilocytic astrocytomas and SEGAs are circumscribed tumors amenable to a (radio)surgical cure. There are few universally accepted guidelines for the treatment of low-grade gliomas. In this review, three neurosurgeons, a neurologist, a neuropathologist, and a radiation oncologist discuss some of the difficult issues surrounding the diagnosis and treatment of low-grade gliomas from their individual points of view (i. e., classification and neuropathology, MR imaging, stereotactic biopsy, microsurgery, interstitial radiotherapy/brachytherapy, radiotherapy, wait and see strategy).
authors: Department of Neurosurgery, University of Bonn, Bonn, Germany. Autor.Schramm@ukb.uni-bonn.de
authors: J
authors: J
authors: Schramm
authors: I
authors: I
authors: Blümcke
authors: C B
authors: CB
authors: Ostertag
authors: U
authors: U
authors: Schlegel
authors: M
authors: M
authors: Simon
authors: J
authors: J
authors: Lutterbach