[Quo vadetis coxibs?].
After the withdrawall of rofecoxib from worldwide market, there is ongoing debate whether gastrointestinal safety of COX-2 inhibition compared to non-selective NSAID-s may come at the cost of increased cardiovascular events. In this paper the relevant data regarding mechanisms, effects and side effects of selected COX-2 inhibitors are presented. Possible class effect is disscused and proposed alternative therapies.
Grazio
Simeon
S
Klinika za reumatologiju, fizikalnu medicinu i i rehabilitaciju Klinicka bolnica Sestre milosrdnice, Zagreb. simeon.grazio@zg.t-com.hr
Anić
Branimir
B