title: Regiospecific hydration of gamma-hydroxy-alpha,beta-acetylenic esters: a novel asymmetric synthesis of tetronic acids.
abstract: [reaction: see text] The optically active gamma-hydroxy-alpha,beta-acetylenic esters are obtained from the enantioselective reaction of methyl propiolate with both aliphatic and aromatic aldehydes. These compounds can undergo regiospecific hydration in the presence of Zeise's dimer, [PtCl(2)(C(2)H(4))](2), to generate the optically active tetronic acids.
authors: Department of Chemistry, University of Virginia, Charlottesville, 22904-4319, USA.
authors: Amaresh R
authors: AR
authors: Rajaram
authors: Lin
authors: L
authors: Pu