title: Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease.
abstract: Core sequences necessary for substrate recognition and its inhibition at the PR/p3 site of HTLV-1 protease were clarified for the first time. From the cleavage rates of peptides containing a part of the PR/p3 site, a heptapeptide was found to be the minimal sequence required for substrate recognition. The use of synthetic inhibitors containing hydroxyethylamine dipeptide isostere indicated that a tetrapeptide sequence was necessary to achieve potent inhibition.
authors: Institute for Protein Research, Osaka University, Osaka 565-0871, Japan.
authors: Hiromi
authors: H
authors: Naka
authors: Kenta
authors: K
authors: Teruya
authors: Jeong Kyu
authors: JK
authors: Bang
authors: Saburo
authors: S
authors: Aimoto
authors: Tadashi
authors: T
authors: Tatsumi
authors: Hiroyuki
authors: H
authors: Konno
authors: Kazuto
authors: K
authors: Nosaka
authors: Kenichi
authors: K
authors: Akaji