title: Transferable anticancer innate immunity in spontaneous regression/complete resistance mice.
abstract: Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rosettes with infiltrating natural killer cells, neutrophils, and macrophages was required for the subsequent destruction of cancer cells through rapid cytolysis. Highly purified natural killer cells, macrophages, and neutrophils from the SR/CR mice independently killed cancer cells in vitro. The independent killing activity by each subset of effector cells is consistent with the observation that the resistance was abolished by depleting total infiltrating leukocytes but not by depleting only one or two subsets of leukocytes. The resistance was completely transferable to WT recipient mice through SR/CR splenocytes, bone marrow cells, or enriched peritoneal macrophages, either for prevention against subsequent cancer challenges or eradication of established malignancy at distant sites.
authors: Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors: Amy M
authors: AM
authors: Hicks
authors: Gregory
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authors: Riedlinger
authors: Mark C
authors: MC
authors: Willingham
authors: Martha A
authors: MA
authors: Alexander-Miller
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authors: Von Kap-Herr
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authors: MJ
authors: Pettenati
authors: Anne M
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authors: Sanders
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authors: Weir
authors: Wei
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authors: Du
authors: Joseph
authors: J
authors: Kim
authors: Andrew J G
authors: AJ
authors: Simpson
authors: Lloyd J
authors: LJ
authors: Old
authors: Zheng
authors: Z
authors: Cui