title: Myelodysplastic syndromes with isolated deletion of the long arm of the chromosome X as a sole cytogenetic change.
abstract: Deletions of Xq are extremely rare events in myelodysplastic syndromes (MDS) patients and were previously described in five patients, in two of them as a sole chromosome abnormality. We found isolated del(Xq) in 3 of 127 MDS patients with clonal chromosome changes. Detailed analysis of clinical and morphological data of presented and previously published cases indicates the following: (1) del(X)(q24) and del(X)(q13) are nonrandom chromosomal abnormalities in MDS; (2) MDS with deletions of Xq affect exclusively females ages 46-65; and (3) deletions of Xq are associated with refractory anemia with excess blasts (RAEB) and indicate an unfavorable prognosis.
authors: Hematological Scientific Center, Novozykovsky pr. 4 A, 125167 Moscow, Russia. olsh@blood.ru
authors: Yulia V
authors: YV
authors: Olshanskaya
authors: Alla I
authors: AI
authors: Udovichenko
authors: Lubov A
authors: LA
authors: Vodinskaya
authors: Eugenia N
authors: EN
authors: Glasko
authors: Elena N
authors: EN
authors: Parovitchnikova
authors: Yurii Yu
authors: YY
authors: Lorie
authors: Valentina N
authors: VN
authors: Dvirnik
authors: Valerii G
authors: VG
authors: Savchenko
authors: Elena V
authors: EV
authors: Domracheva