Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
Murakami
Mário T
MT
Department of Physics, IBILCE/UNESP, São José do Rio Preto-SP, Brazil.
Melo
Cristiane C
CC
Angulo
Yamileth
Y
Lomonte
Bruno
B
Arni
Raghuvir K
RK