title: High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease.
abstract: We screened 134 consecutive patients with von Willebrand disease (VWD) (106 type 1, 26 type 2, and 2 type 3 VWD) for the most important inherited prothrombotic risk factors. One hundred eight patients (80.6%) were positive for at least one of the prothrombotic risk factors screened for. A high prevalence of prothrombin G20210A (10.5%) and factor V Leiden (11.9%) mutations was found with allele frequencies of 5.2 and 6%, respectively. Three carriers of multiple prothrombotic gene mutations experienced a thrombotic event. Our study suggests that the recent evidence of an association between inherited thrombotic and hemorrhagic disorders also holds true in VWD patients.
authors: Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy. massimo.franchini@mail.azosp.vr.it
authors: Massimo
authors: M
authors: Franchini
authors: Dino
authors: D
authors: Veneri
authors: Giovanni
authors: G
authors: Poli
authors: Franco
authors: F
authors: Manzato
authors: Gian Luca
authors: GL
authors: Salvagno
authors: Giuseppe
authors: G
authors: Lippi