title: Addressable molecular tweezers for DNA-templated coupling reactions.
abstract: Here we report the construction of fully addressable DNA-based molecular tweezers to actuate coupling reactions in a programmable fashion. Three tweezers, each bearing two coupling reactants, are self-assembled on a linear DNA track. A fourth tweezer floating freely in solution can be brought to any one of the tweezers and close them by the addition of a unique pair of "fuel" DNA strands. The coupling reactions happen when the tweezers are closed, and this can be controlled sequentially from one tweezer to another. A molecular device of this kind would not only enable programmable chemical reactions but also allow distance-dependent control of biomolecular interactions.
authors: Department of Chemistry and Biochemistry and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
authors: Rahul
authors: R
authors: Chhabra
authors: Jaswinder
authors: J
authors: Sharma
authors: Yan
authors: Y
authors: Liu
authors: Hao
authors: H
authors: Yan