[Comparative analysis of intimal hyperplasia after sirolimus-eluting stent and thin-strut bare-metal stent implantation in small coronary arteries].
OBJECTIVE
This study aimed at evaluating reduction in intimal hyperplasia volume following angioplasty using sirolimus-eluting stents (Cypher) compared with thin-strut bare-metal stents (Pixel) in patients with small vessels.


METHODS
Eighty patients with coronary artery disease were prospectively included in two consecutive series, the first using sirolimus-eluting stents (50) and the second using bare-metal stents (30).


RESULTS
The use of sirolimus-eluting stents reduced: in-stent net volume obstruction [5.0% (SE = 0.77) x 39.0% (SE = 4.72), p < 0.001], in-stent late loss [0.25 mm (SE = 0.03) x 1,11 mm (SE = 0.13), p < 0.001], in-segment late loss [0.30 mm (SE = 0.04) x 0.83 mm (SE = 0.11), p < 0.001], in-stent restenosis (0% x 33.3%, p < 0.001) and in-segment restenosis (4% x 36.7%, p < 0.001). The event-free survival rate was 96% in the sirolimus-eluting stent group versus 86.7% in the bare-metal stent group (BMS) (p = 0.190).


CONCLUSIONS
Sirolimus-eluting stents are superior to thin-strut bare-metal stents in reducing intimal hyperplasia (less in-stent obstruction and less late lumen loss) in patients with small vessels. The use of these stents significantly reduced angiographic restenosis at eight months.
Devito
Fernando Stuchi
FS
Instituto Dante Pazzanese de Cardiologia, São Paulo, SP. fdevito@cardiol.br
Sousa
Amanda G M R
AG
Feres
Fausto
F
Abizaid
Alexandre Antonio Cunha
AA
Staico
Rodolfo
R
Mattos
Luis Alberto Piva
LA
Tanajura
Luis Fernando Leite
LF
Abizaid
Andréa C L S
AC
Chaves
Aurea Jacob
AJ
Sousa
J Eduardo M R
JE