title: Gaps in scientific knowledge for the post eradication world.
abstract: There are significant gaps in the understanding of polio and polio vaccines which have programmatic importance even after 50 years of vaccine use. This paper considers four: the effect of strains used in the manufacture of IPV on safety and efficacy, the reasons for the safety of the Sabin strains, the nature and detection of long-term excreters of poliovirus and the basis for the cessation of virus excretion.
authors: National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. pminor@nibsc.ac.uk
authors: Philip
authors: P
authors: Minor