title: Progression to dementia in clinical subtypes of mild cognitive impairment.
abstract: OBJECTIVE
  To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI).
  
  
  METHODS
  A follow-up examination (average follow-up period: 3.49 +/- 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline.
  
  
  RESULTS
  8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia. The clinical type of MCI is significantly associated with the likelihood of conversion to dementia.
  
  
  CONCLUSIONS
  When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia.
authors: Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany. palexopoulos@freemail.gr
authors: P
authors: P
authors: Alexopoulos
authors: T
authors: T
authors: Grimmer
authors: R
authors: R
authors: Perneczky
authors: G
authors: G
authors: Domes
authors: A
authors: A
authors: Kurz