The impact of parallel chemistry in drug discovery.
With the application of parallel synthesis of single compounds to drug-discovery efforts, improvements in the efficiency of synthesis are possible. However, for improvements to occur in effective drug design - a critical requirement to increase productivity in the modern pharmaceutical industry - the implementation of in silico design hypotheses that incorporate comprehensive information on a target, including considerations of absorption, distribution, metabolism and excretion, is also necessary. Concomitantly, the use of automated methods of synthesis and purification is also required to improve drug design. Combining all of these elements allows the possibility to uncover unique insights into a biological target quickly and to therefore accelerate the rate of drug discovery.
Edwards
Paul J
PJ
Department of Medicinal Chemistry, Galapagos NV, Industriepark Mechelen Noord, Generaal De Wittelaan L11 A3, B-2800 Mechelen, Belgium. paul.edwards@glpg.com