title: Preprocessing of tandem mass spectrometric data based on decision tree classification.
abstract: In this study, we present a preprocessing method for quadrupole time-of-flight (Q-TOF) tandem mass spectra to increase the accuracy of database searching for peptide (protein) identification. Based on the natural isotopic information inherent in tandem mass spectra, we construct a decision tree after feature selection to classify the noise and ion peaks in tandem spectra. Furthermore, we recognize overlapping peaks to find the monoisotopic masses of ions for the following identification process. The experimental results show that this preprocessing method increases the search speed and the reliability of peptide identification.
authors: Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China, China. jfzhang@jdl.ac.cn
authors: Jing Fen
authors: JF
authors: Zhang
authors: Si Min
authors: SM
authors: He
authors: Jin Jin
authors: JJ
authors: Cai
authors: Xing Jun
authors: XJ
authors: Cao
authors: Rui Xiang
authors: RX
authors: Sun
authors: Yan
authors: Y
authors: Fu
authors: Rong
authors: R
authors: Zeng
authors: Wen
authors: W
authors: Gao