title: Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.
abstract: New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
authors: Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA.
authors: Robert W
authors: RW
authors: Wiethe
authors: Eugene L
authors: EL
authors: Stewart
authors: David H
authors: DH
authors: Drewry
authors: David W
authors: DW
authors: Gray
authors: Abdul
authors: A
authors: Mehbob
authors: William J
authors: WJ
authors: Hoekstra