The structural basis of paramyxovirus invasion.
To deliver their genetic material into host cells, enveloped viruses have surface glycoproteins that actively cause the fusion of the viral and cellular membranes. Recently determined X-ray crystal structures of the paramyxovirus fusion (F) protein in its pre-fusion and post-fusion conformations reveal the dramatic structural transformation that this protein undergoes while causing membrane fusion. Conformational changes in key regions of the F protein suggest the mechanism by which the F protein is activated and refolds.
Russell
Charles J
CJ
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA. charles.russell@stjude.org
Luque
Laura E
LE