title: Treatment of Japanese restless legs syndrome patients with cabergoline: an open clinical preliminary trial.
abstract: OBJECTIVE
  To determine the effective dose of cabergoline in Japanese patients with restless legs syndrome (RLS).
  
  
  METHODS
  Six cases of idiopathic RLS and three of RLS with Parkinson disease (PD) participated in an open clinical preliminary trial. All cases were diagnosed based on the clinical criteria of the International RLS Study Group. Three RLS cases (1.3%) were detected out of 229 consecutive cases with PD. RLS severity was evaluated with International RLS Study Group (IRLSSG) Rating Scale Version 2.2 before and one year after the treatment with cabergoline.
  
  
  RESULTS
  For 6 idiopathic RLS patients, the IRLSSG questionnaire scores improved from 25.5+/-3.7 to 10.7+/-8.9 (p=0.028, Wilcoxon test) with 1 mg of daily cabergoline at the endpoint. For 3 RLS cases with PD, the score was 21.7+/-3.7 before the treatment, and RLS symptoms completely disappeared with 1 mg of cabergoline. One of RLS cases with PD required additional cabergoline later because of parkinsonism. No adverse event with cabergoline was reported in this study.
  
  
  CONCLUSIONS
  One mg of daily cabergoline is effective in some Japanese patients of RLS.
authors: First Department of Medicine, Asahikawa Medical College, Asahikawa.
authors: Hitoshi
authors: H
authors: Aizawa
authors: Yoko
authors: Y
authors: Aburakawa
authors: Yasuhiro
authors: Y
authors: Suzuki
authors: Hiroyuki
authors: H
authors: Enomoto
authors: Yoshihiro
authors: Y
authors: Makita
authors: Kenjiro
authors: K
authors: Kikuchi
authors: Takashi
authors: T
authors: Kimura
authors: Osamu
authors: O
authors: Yahara