Porphyrins conjugated to DNA as CD reporters of the salt-induced B to Z-DNA transition.
The porphyrin chromophore incorporated at the 5'-position of an oligonucleotide allows the simultaneous detection of the B- to Z-DNA transition via the porphyrin Soret band circular dichroism exciton couplet signal around 420 nm and the oligonucleotide CD region below 300 nm, at micromolar concentrations.
Balaz
Milan
M
Columbia University, Department of Chemistry, 3000 Broadway, New York, New York 10027, USA. milan.balaz@chem.ox.ac.uk
Li
Benjamin C
BC
Steinkruger
Jay D
JD
Ellestad
George A
GA
Nakanishi
Koji
K
Berova
Nina
N