title: Unusual temperature dependence of enantioselectivity in asymmetric reductions by chiral NADH models.
abstract: [reaction: see text] Unusual stereoselectivity changes, i.e., enhancement and inversion of enantioselectivity with increasing temperature, were observed in the asymmetric reduction of methyl benzoylformate with chiral 1,4-dihydropyridines possessing amino acid residues as ligating chiral auxiliaries. The differential activation parameters, DeltaDeltaH(S-R) and DeltaDeltaS(S-R), obtained from the Eyring plots demonstrate that the entropy term controls the enantiodifferentiating step, accounting for the observed unique temperature dependencies.
authors: Department of Materials and Life Science, Seikei University, Musashino, Japan. rsaito@st.seikei.ac.jp
authors: Ryota
authors: R
authors: Saito
authors: Shoichiro
authors: S
authors: Naruse
authors: Koji
authors: K
authors: Takano
authors: Keiko
authors: K
authors: Fukuda
authors: Akira
authors: A
authors: Katoh
authors: Yoshihisa
authors: Y
authors: Inoue