Triazole-based monophosphine ligands for palladium-catalyzed cross-coupling reactions of aryl chlorides.
A variety of triazole-based monophosphines (ClickPhos) have been prepared via efficient 1,3-dipolar cycloaddition of readily available azides and acetylenes. Their palladium complexes provided excellent yields in the amination reactions and Suzuki-Miyaura coupling reactions of unactivated aryl chlorides. Ligand 7i, which has a 2,6-dimethoxybenzene moiety, provided good results in Suzuki-Miyaura reaction to form hindered biaryls. A CAChe model for the Pd/7i complex shows that the likelihood of a Pd-arene interaction might be a rationale for its high catalytic reactivity.
Dai
Qian
Q
Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Gao
Wenzhong
W
Liu
Duan
D
Kapes
Lea M
LM
Zhang
Xumu
X