title: A study of Gleason score interpretation in different groups of UK pathologists; techniques for improving reproducibility.
abstract: OBJECTIVE
  To test the effectiveness of a teaching resource (a decision tree with diagnostic criteria based on published literature) in improving the proficiency of Gleason grading of prostatic cancer by general pathologists.
  
  
  METHODS
  A decision tree with diagnostic criteria was developed by a panel of urological pathologists during a reproducibility study. Twenty-four general histopathologists tested this teaching resource. Twenty slides were selected to include a range of Gleason score groups 2-4, 5-6, 7 and 8-10. Interobserver agreement was studied before and after a presentation of the decision tree and criteria. The results were compared with those of the panel of urological pathologists.
  
  
  RESULTS
  Before the teaching session, 83% of readings agreed within +/- 1 of the panel's consensus scores. Interobserver agreement was low (kappa = 0.33) compared with that for the panel (kappa = 0.62). After the presentation, 90% of readings agreed within +/- 1 of the panel's consensus scores and interobserver agreement amongst the pathologists increased to kappa = 0.41. Most improvement in agreement was seen for the Gleason score group 5-6.
  
  
  CONCLUSIONS
  The lower level of agreement among general pathologists highlights the need to improve observer reproducibility. Improvement associated with a single training session is likely to be limited. Additional strategies include external quality assurance and second opinion within cancer networks.
authors: Department of Pathology, Cardiff University, Cardiff, UK. griffithsdr@cf.ac.uk
authors: D F R
authors: DF
authors: Griffiths
authors: J
authors: J
authors: Melia
authors: L J
authors: LJ
authors: McWilliam
authors: R Y
authors: RY
authors: Ball
authors: K
authors: K
authors: Grigor
authors: P
authors: P
authors: Harnden
authors: M
authors: M
authors: Jarmulowicz
authors: R
authors: R
authors: Montironi
authors: R
authors: R
authors: Moseley
authors: M
authors: M
authors: Waller
authors: S
authors: S
authors: Moss
authors: M C
authors: MC
authors: Parkinson