[Calreticulin, Ca2+-binding chaperon of the endoplasmic reticulum].
The endoplasmic reticulum (ER) plays a vital role in many cellular processes, including Ca2+ storage and release. Calreticulin is a Ca2+-binding chaperon residing in ER. The protein is a key component of the quality control pathways in ER. In the ER lumen, calreticulin performs two major functions, works as a chaperon and regulates Ca2+ homeostasis. In cardiac muscle, calreticulin plays an important role in cardiac development and pathology.
Szperl
Małgorzata
M
Laboratory of Molecular Biology, Institute of Kardiology, 42 Alpejska St., 04-628 Warszawa, Poland. mszperl@yahoo.com
Opas
Michał
M