Metabolic alteration transients during paroxysmal activity in an epileptic patient with fixation-off sensitivity: a case study.
The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side.
Giove
Federico
F
Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, 00184 Rome, Italy.
Garreffa
Girolamo
G
Peca
Stefano
S
Carní
Marco
M
Macrì
Maria Antonietta
MA
Di Bonaventura
Carlo
C
Vaudano
Anna Elisabetta
AE
Giallonardo
Anna Teresa
AT
Prencipe
Massimiliano
M
Bozzao
Luigi
L
Pantano
Patrizia
P
Colonnese
Claudio
C
Maraviglia
Bruno
B