[Sensory gating of patients with first-episode schizophrenia].
OBJECTIVE
To investigate the characteristics of sensory gating P50 of patients with first-episode schizophrenia.


METHODS
The auditory evoked potentials P50 were recorded in 66 patients (Group Sch) with first-episode schizophrenia and 92 normal controls (Group NC) by using conditioning/testing paradigm presented with auditory double click stimuli.


RESULTS
The value of S1-P50 of Group Sch was 3 microV +/- 2 microV, significantly lower than that of Group NC (6 microV +/- 3 microV, P <0.01). The value of S2-P50 of Group Sch was 4 microV +/- 2 microV, significantly higher than that of Group NC (2 microV +/- 1 microV, P < 0.01). The S2/S1 ratio of Group Sc was 81% +/- 40%, significantly higher than that of Group NC (42% +/- 21%, P < 0.01). The value of S2 - S1 of Group Sch was 2 microV +/- 1 mciroV, significantly lower than that of Group Sch (3 mciroV +/- 2 microV). The value of 100 (1-S2/S1) of Group Sch was 19% +/- 17%, significantly lower than that of Group NC (58% +/- 21% , P < 0.01).


CONCLUSIONS
Sensory gating deficit exists in the patients with first-episode schizophrenia, manifested in deficiency of inhibition that can be quantitatively observed by measuring auditory evoked potential P50.
Chen
Xing-shi
XS
Department of Electrophysiology, Shanghai Institute of Mental Health, Shanghai 200030, China.
Zhang
Ming-dao
MD
Wang
Hong-xing
HX
Lou
Cui-ying
CY
Wang
Ji-jun
JJ
Guo
Qi
Q
Liu
Li
L
Gao
Cun-you
CY
Liu
Ping
P
Liu
Xiao-wei
XW
Duan
Hui-jun
HJ
Guo
Feng-lian
FL
Liang
Jian-hua
JH
Chen
Chong
C
Chen
Xin-wei
XW