[Roles of vasodilator-stimulated phosphoprotein in the regulation of cytoskeleton].
Regulation of cytoskeletal dynamics is required to coordinate cell adhesion, morphology change and cell motility. Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein which is composed of EVH1, EVH2 domains and PRR. It has been implicated in actin-based processes such as axon guidance, T cell polarization and fibroblast migrations. The regulation of VASP phosphorylation, which is controlled by PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase), could correspond to the "switch" process in its communication with cytoskeleton during modification of focal adhesion.
Wang
Ting-Ting
TT
Department of Pathophysiology ,Medical College of Wuhan University, Wuhan 430071, China.
Li
Ke
K
Wei
Lei
L