Chiral silanes via asymmetric hydrosilylation with catalytic CuH.
[reaction: see text] CuH-catalyzed asymmetric conjugate reduction of beta-silyl-alpha,beta-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)(2) leads to highly enantioselective 1,4-reductions.
Lipshutz
Bruce H
BH
Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, USA. lipshutz@chem.ucsb.edu
Tanaka
Naoki
N
Taft
Benjamin R
BR
Lee
Ching-Tien
CT