title: Netherton syndrome: report of identical twins presenting with severe atopic dermatitis.
abstract: We report the cases of 4-year-old identical twin sisters who presented with severe atopic dermatitis with intractable skin manifestations and multiple food allergies. Netherton syndrome (NS) (OMIM 256500) was suspected due to very high serum IgE levels, growth retardation, severe food allergies and typical hair finding (trichorrhexis invaginata). A definite diagnosis was made by genetic analysis. Our cases are unique in being the first identical twins with NS diagnosed by a novel mutation in the SPINK5 gene. NS should be considered in differential diagnosis in children who have generalized erythema with intractable eczematous lesions and elevated levels of IgE.
authors: Department of Pediatrics, Division of Pediatric Allergy and Chest Diseases, Istanbul University, Istanbul Medical School, Istanbul, Turkey. kilicgurkan@yahoo.com
authors: Gurkan
authors: G
authors: Kilic
authors: Nermin
authors: N
authors: Guler
authors: Ulker
authors: U
authors: Ones
authors: Zeynep
authors: Z
authors: Tamay
authors: Pinar
authors: P
authors: Guzel