title: Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.
abstract: Fosmidomycin is a promising antimalarial drug candidate with a unique chemical structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analogue FR900098 have been synthesized and their in vitro antimalarial activity versus the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined.
authors: Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, D-20146 Hamburg, Germany. kurz@chemie.uni-hamburg.de
authors: Thomas
authors: T
authors: Kurz
authors: Katrin
authors: K
authors: Schlüter
authors: Uwe
authors: U
authors: Kaula
authors: Bärbel
authors: B
authors: Bergmann
authors: Rolf D
authors: RD
authors: Walter
authors: Detlef
authors: D
authors: Geffken