In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.
In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.
Henry
Pierre-Gilles
PG
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. henry@cmrr.umn.edu
Adriany
Gregor
G
Deelchand
Dinesh
D
Gruetter
Rolf
R
Marjanska
Malgorzata
M
Oz
Gülin
G
Seaquist
Elizabeth R
ER
Shestov
Alexander
A
Uğurbil
Kâmil
K