title: Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space.
abstract: We manually defined the inferior frontal gyrus (IFG) on high-resolution MRIs in native space in 30 healthy subjects (15 female, median age 31 years; 15 male, median age 30 years), resulting in 30 individual atlases. Using standard software (SPM99), these were spatially transformed to a widely used stereotaxic space (MNI/ICBM 152) to create probabilistic maps. In native space, the total IFG volume was on average 5%, and the gray matter (GM) portion 12% larger in women (not significant). Expressed as a percentage of ipsilateral frontal lobe volume (i.e., correcting for brain size), the IFG was an average of 20%, and the GM portion of the IFG 27%, larger in women (P < 0.005). Correcting for total lobar volume yielded the same result. No asymmetry was found in IFG volumes. There were significant positional differences between the right and left IFGs, with the right IFG being further lateral in both native and stereotaxic space. Variability was similar on the left and right, but more pronounced anteriorly and superiorly. We show differences in IFG volume, composition, and position between sexes and between hemispheres. Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients.
authors: MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. alexander.hammers@csc.mrc.ac.uk
authors: Alexander
authors: A
authors: Hammers
authors: Chi-Hua
authors: CH
authors: Chen
authors: Louis
authors: L
authors: Lemieux
authors: Richard
authors: R
authors: Allom
authors: Spyridon
authors: S
authors: Vossos
authors: Samantha L
authors: SL
authors: Free
authors: Ralph
authors: R
authors: Myers
authors: David J
authors: DJ
authors: Brooks
authors: John S
authors: JS
authors: Duncan
authors: Matthias J
authors: MJ
authors: Koepp