title: Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits.
abstract: Growth factors are known to appear during wound healing. We hypothesized that growth factors would also appear during the healing process of a rotator cuff tear. We determined the expression of various growth factors during healing of acute rotator cuff tears in the rabbit. We made a full-thickness defect in the supraspinatus tendon of 27 Japanese white rabbits. The shoulders were harvested on days 1, 3, 5, 7, 9, 11, 14, 21, and 28 postoperatively (n = 3 at each time point). We assessed the expression of basic fibroblast growth factor, insulin-like growth factor 1, platelet-derived growth factor, and transforming growth factor beta. Basic fibroblast growth factor appeared with its peak on days 7 and 9, insulin-like growth factor 1 appeared with its peak on day 5, platelet-derived growth factor appeared with a mild expression between days 7 and 14, and transforming growth factor beta appeared with constant mild expression throughout the observation period. It is likely that each of these growth factors plays a role in the early phase of healing of the supraspinatus tendon in rabbits.
authors: Department of Orthopedic Surgery, Akita University School of Medicine, Akita, Japan.
authors: Moto
authors: M
authors: Kobayashi
authors: Eiji
authors: E
authors: Itoi
authors: Hiroshi
authors: H
authors: Minagawa
authors: Naohisa
authors: N
authors: Miyakoshi
authors: Shu
authors: S
authors: Takahashi
authors: Yilihamu
authors: Y
authors: Tuoheti
authors: Kyoji
authors: K
authors: Okada
authors: Yoichi
authors: Y
authors: Shimada