title: Successful doxycycline treatment of lymphatic fistulas: report of five cases and review of the literature.
abstract: OBJECTIVE
  Lymphatic fistulas are commonly known complications after lymph node or soft tissue resection, requiring long and sometimes difficult therapy. Doxycycline is an antibiotic agent, which was used in the treatment of pneumothoraces and pleural effusions. The aim of the study was to evaluate the effect of local doxycycline instillation on postoperative lymphatic effusions.
  
  
  METHODS
  Five patients with postoperative lymphatic fistulas of different locations (inguinal, gluteal, and thoracic) were included. Patients received local doxycycline instillation after a postoperative observation period of 19-27 days without spontaneous closure of the fistulas.
  
  
  RESULTS
  Postoperative lymphatic fistulas closed after a single injection of doxycycline in four out of five patients within 2 days, in one patient, injection had to be repeated to achieve closure of the fistula. Drain removal was possible within 4 days after instillation in all patients; no complications occurred.
  
  
  CONCLUSIONS
  Doxycycline can be used for treatment of persistent postoperative lymphatic fistulas in different locations. In further studies, this therapeutic concept should be evaluated with larger numbers of patients with regard to the ideal point of time, frequency, and mode of application.
authors: Department of Surgery, Im Neuenheimer Feld 110, Heidelberg 69120, Germany. Thilo_Hackert@med.uni-heidelberg.de
authors: Thilo
authors: T
authors: Hackert
authors: Jens
authors: J
authors: Werner
authors: Martin
authors: M
authors: Loos
authors: Markus W
authors: MW
authors: Büchler
authors: Jürgen
authors: J
authors: Weitz