[Genetic mechanisms in the hereditary predisposition to colorectal cancer].
A proportion of colorectal cancers shows some type of genetic predisposition that can be recognised in clinical practice. From the classical dominant inheritance pattern of familial adenomatous polyposis or hereditary non-polyposis colorectal cancer, through the recessive transmission of the MYH associated polyposis, to the new syndromes of the "serrated pathway" or low-penetrance alleles, the discovery of new genes and a deeper understanding of the mechanisms of action of already-known ones are enabling us to understand new aspects of the colorectal carcinogenesis. This is throwing a new light on some of the observed familial aggregation patterns which had remained unexplained.
Alonso
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Servicio de Genética, Hospital Virgen del Camino, Pamplona. aalonsos@cfnavarra.es
Moreno
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Valiente
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Artigas
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Pérez-Juana
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Ramos Arroyo
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