title: Association of phosphodiesterase 4D polymorphisms with ischemic stroke in a US population stratified by hypertension status.
abstract: OBJECTIVE
  Phosphodiesterase 4D (PDE4D) underlies the STRK1 linkage peak for stroke on chromosome 5q12 identified in Iceland. We tested association of 13 single-nucleotide polymorphisms (SNPs) and 1 microsatellite in a nested case-control sample of elderly white women (>65 years of age) from the Study of Osteoporotic Fractures (SOF) in the United States.
  
  
  METHODS
  The genotypes of 248 women who experienced an incident ischemic stroke during an average of 5.4 years of follow-up were compared with 560 controls.
  
  
  RESULTS
  Marginal associations with stroke (P<0.10) were found for 3 polymorphisms. Stratification of the population by hypertension markedly strengthened the association. SNPs 9 (hazard ratio [HR], 0.48; 95% CI, 0.26 to 0.91), 42 (HR, 1.73; 95% CI, 1.10 to 2.70), 219 (HR, 1.73; 95% CI, 1.13 to 2.64), and 220 (HR, 1.56; 95% CI, 1.05 to 2.32) showed significant association with stroke (P<0.05) under a dominant model in subjects without hypertension at baseline, and SNP 175 was significantly associated with stroke under an additive model (HR, 0.76; 95% CI, 0.59 to 0.98) in subjects with hypertension. Furthermore, the microsatellite AC008818-1 showed association with stroke only in the nonhypertensive subjects. Based on results in Iceland, specific haplotypes were tested in SOF, and stratification by hypertension also affected these association results.
  
  
  CONCLUSIONS
  These data are consistent with an association of the PDE4D gene with stroke in a non-Icelandic sample and suggest an effect of hypertension status.
authors: Roche Molecular Systems, Alameda, CA 94501, USA. victoria_h.brophy@roche.com
authors: Victoria H
authors: VH
authors: Brophy
authors: Sunhee K
authors: SK
authors: Ro
authors: Brian K
authors: BK
authors: Rhees
authors: Li-Yung
authors: LY
authors: Lui
authors: Jocelyn M
authors: JM
authors: Lee
authors: Nanette
authors: N
authors: Umblas
authors: L Gordon
authors: LG
authors: Bentley
authors: Jia
authors: J
authors: Li
authors: Suzanne
authors: S
authors: Cheng
authors: Warren S
authors: WS
authors: Browner
authors: Henry A
authors: HA
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