A qualitative study of amlodipine and its related compounds by electrospray ionization tandem mass spectrometry.
A comprehensive structural analysis of amlodipine and certain related compounds was performed by electrospray ionization tandem mass spectrometry. Triple quadrupole and quadrupole time-of-flight instruments were used to provide collision-induced dissociation and accurate mass measurement for selected product and second-generation product ions. A unique ion rearrangement was observed, which was found to be characteristic of certain dihydropyridines. This study provides a fundamental understanding of the fragmentation of these compounds. The structural elucidation of an unknown impurity is presented as an example.
Gibbons
John
J
Genpharm Inc., 85 Advance Road, Etobicoke, Ontario, Canada. johng@genpharm.ca
Pugh
Jonathan
J
Dimopoulos-Italiano
Gina
G
Pike
Richard
R