title: Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents.
abstract: Five- and six-membered heterocyclic ionone-like derivatives 4-6 have been synthesised in one step and with good yield from the key intermediate 3a and appropriate bifunctional reagents. Four were active as inhibitors of the respiratory burst of human neutrophils without affecting cell viability. The two most active compounds (5a,d) tested in neutrophil migration assays, were also found to be potent inhibitors of neutrophil chemotactic responsiveness. These two molecules could be considered as lead compounds of new drugs which can be an effective tool to treat psoriasis and related neutrophilic dermatoses.
authors: Dipartimento di Scienze Farmaceutiche, Viale Benedetto XV, 3 Genova, Italy. balbi@unige.it
authors: Alessandro
authors: A
authors: Balbi
authors: Maria
authors: M
authors: Anzaldi
authors: Mauro
authors: M
authors: Mazzei
authors: Mariangela
authors: M
authors: Miele
authors: Maria
authors: M
authors: Bertolotto
authors: Luciano
authors: L
authors: Ottonello
authors: Franco
authors: F
authors: Dallegri