title: Retinal, pineal and diencephalic expression of frog arylalkylamine N-acetyltransferase-1.
abstract: The arylalkylamine N-acetyltransferase (AANAT) is a key enzyme in the rhythmic production of melatonin. Two Aanats are expressed in Teleost fish (Aanat1 in the retina and Aanat2 in the pineal organ) but only Aanat1 is found in tetrapods. This study reports the cloning of Aanat1 from R. perezi. Transcripts were mainly expressed in the retina, diencephalon, intestine and testis. In the retina and pineal organ, Aanat1 expression was in the photoreceptor cells. Expression was also seen in ependymal cells of the 3rd ventricle and discrete cells of the suprachiasmatic area. The expression of Aanat1 in both the retina and pineal organ, and the absence of Aanat2 suggests that green frog resembles more to birds and mammals than to Teleost fish, as far as Aanat is concerned. The significance of Aanat1 in extra-pineal and extra-retinal tissues remains to be elucidated; in the diencephalon, it might be associated to the so-called deep brain photoreceptor cells.
authors: Laboratoire Aragó, Université Pierre et Marie Curie and CNRS, UMR 7628, B.P. 44, Avenue du Fontaulé, F-66651 Banyuls/Mer-Cedex, France.
authors: Esther
authors: E
authors: Isorna
authors: Laurence
authors: L
authors: Besseau
authors: Gilles
authors: G
authors: Boeuf
authors: Yves
authors: Y
authors: Desdevises
authors: Robin
authors: R
authors: Vuilleumier
authors: Angel L
authors: AL
authors: Alonso-Gómez
authors: María J
authors: MJ
authors: Delgado
authors: Jack
authors: J
authors: Falcón