title: Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.
abstract: A novel prodrug strategy for cyclin-dependent kinase inhibitor JNJ-7706621 has been explored. Through N-acylation of a sulfonamide substituent, tails containing different solubilizing groups (amino, carboxyl, alkoxyl, and hydroxyl) were attached to JNJ-7706621. Most of the prodrugs exhibited good aqueous solubility and the N-acyl groups on the sulfonamide were metabolically cleaved to generate active drug in rat PK study.
authors: Johnson & Johnson Pharmaceutical Research & Development LLC, 1000 Route 202, Raritan, NJ 08869, USA. shenlinhuang@hotmail.com
authors: Shenlin
authors: S
authors: Huang
authors: Peter J
authors: PJ
authors: Connolly
authors: Ronghui
authors: R
authors: Lin
authors: Stuart
authors: S
authors: Emanuel
authors: Steve A
authors: SA
authors: Middleton