title: The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.
abstract: Ibudilast is widely used in Japan to treat ischemic stroke and bronchial asthma. Its mode of action is through the inhibition of cyclic nucleotide phosphodiesterases (PDEs). Growing evidence suggests this compound has utility in a range of neurological conditions linked to its ability to elevate cellular cyclic nucleotide concentrations, however limited data exists on Ibudilast's action on individual PDE families. We therefore used an extensive panel of human PDE enzymes to define the PDE inhibitory profile of this compound. Ibudilast preferentially inhibits PDE3A, PDE4, PDE10 and PDE11 with lesser inhibition of a number of other families. The significance of these findings is discussed in relation to Ibudilast's observed effects on certain disease states.
authors: Kyorin Scotland Research Laboratories, Scottish Biomedical, Todd Campus, West of Scotland Science Park, Glasgow, Scotland, G20 0XA, UK.
authors: Lucien C D
authors: LC
authors: Gibson
authors: Stuart F
authors: SF
authors: Hastings
authors: Ian
authors: I
authors: McPhee
authors: Robert A
authors: RA
authors: Clayton
authors: Claire E
authors: CE
authors: Darroch
authors: Alison
authors: A
authors: Mackenzie
authors: Fiona L
authors: FL
authors: Mackenzie
authors: Michiaki
authors: M
authors: Nagasawa
authors: Patricia A
authors: PA
authors: Stevens
authors: Simon J
authors: SJ
authors: Mackenzie