The effect of the administration of human gamma globulins in a model of BCG infection in mice.
The effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration to mice of human gamma globulins. This treatment of mice inhibited BCG colonization of the lungs (p < 0.01). A similar inhibitory effect was observed after infection of mice with gamma globulin opsonized BCG organisms (p < 0.01). These results are relevant for the development of new strategies for the control and treatment of tuberculosis.
Olivares
Nesty
N
Department of Molecular Biology, Finlay Institute, La Lisa, Havana City, Cuba.
León
Annette
A
López
Yamilé
Y
Puig
Alina
A
Cádiz
Armando
A
Falero
Gustavo
G
Martínez
Máximo
M
Sarmiento
Marie E
ME
Fariñas
Mildrey
M
Infante
Juan F
JF
Sierra
Gustavo
G
Solís
Rosa L
RL
Acosta
Armando
A