Lanthanum potentiates GABA-activated currents in rat pyramidal neurons of CA1 hippocampal field.
In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum.
Boldyreva
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Brain Research Institute, Russian Academy of Medical Sciences, Moscow.