Evidence that Clostridium difficile TcdC is a membrane-associated protein.
Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.
Govind
Revathi
R
Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, 79430, USA.
Vediyappan
Govindsamy
G
Rolfe
Rial D
RD
Fralick
Joe A
JA