Solution-phase parallel synthesis of a pyridinium pyrazol-3-olate inner salt library using a three-component reaction.
We present here the discovery of a novel, versatile, multicomponent reaction leading to various 4-[4-(pyridinium-1-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-pyrazol-3-olate inner salts. The structure of the unusual zwitterionic inner salts was elucidated, and the scope of the novel reaction was investigated. After rapid optimization, the reaction was adapted to parallel synthesis, and an 800-membered compound library was produced.
Varga
Laszló
L
ComGenex Inc., Budapest, Hungary. laszlo.varga@comgenex.hu
Nagy
Tamas
T
Dorman
György
G
Kalman
Ferenc
F
Urge
Laszló
L
Darvas
Ferenc
F