title: Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate the expression of cyclooxygenase-2 in human breast cancer using immunohistochemistry and to determine whether the expression of cyclooxygenase-2 is associated with clinicopathological factors in invasive ductal breast carcinoma.
  
  
  METHODS
  Cyclooxygenase-2 expression was investigated by immunohistochemistry in 30 invasive ductal breast carcinoma specimens and relationships between cyclooxygenase-2 expression and age, histological grade, histological type, nodal status, and hormone receptor status were evaluated.
  
  
  RESULTS
  Cyclooxygenase-2 expression was found in 56.7% of the tumor samples and was related to histological grade (P<0.01) and histological type (P<0.001).
  
  
  CONCLUSIONS
  Our results suggest that cyclooxygenase-2 expression has an important role in tumor differentiation in invasive ductal breast carcinoma.
authors: Department of Surgical Oncology, Graduate School of Medicine, Tokyo Medical and Dental University 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors: Emiko
authors: E
authors: Takeshita
authors: Takayuki
authors: T
authors: Osanai
authors: Tetsuro
authors: T
authors: Higuchi
authors: Labile Togba
authors: LT
authors: Soumaoro
authors: Kenichi
authors: K
authors: Sugihara