Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.
Mc Carthy
Orla K
OK
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
Schipani
Alessandro
A
Buendía
Alex Musso
AM
Ruiz-Perez
Luis M
LM
Kaiser
Marcel
M
Brun
Reto
R
Pacanowska
Dolores González
DG
Gilbert
Ian H
IH