[The effects of rapid and slow infusion of fluid on coagulation factors in hemorrhagic shock: an experimental dogs model].
BACKGROUND
The diagnosis of hemorrhagic shock in a patient with tachycardia and hypotension is generally straightforward. The difficulty lies in the selection of optimal approach for the patient. In this study on a canine model of deep hemorrhagic shock induced by bleeding, we used various amounts of fluid infusion to determine the most appropriate amount of fluid resuscitation.


METHODS
The study included 30 mongrel dogs. Mongrel dogs were randomized to three equal groups of 10. The control group received no treatment. The rapid infusion group received 60 mL/kg of lactated Ringer's solution in half an hour whereas the third group received 30 mL/kg during the same time period.


RESULTS
The lactate decreased in the two treatment groups. The platelet and fibrinogen levels did not vary in the slow infusion group but decreased markedly in the rapid infusion group.


CONCLUSIONS
In conclusion, fluid resuscitation should not be unnecessarily aggressive. The coagulation parameters are diluted in proportion with the amount of fluid given. Blood lactate level can be used as a guiding marker in evaluation of treatment effectiveness of hemorrhagic shock patients.
Ikizceli
Ibrahim
I
Department of Emergency Medicine, Medicine Faculty of Erciyes University, Kayseri, Turkey. ikizceli@erciyes.edu.tr
Sözüer
Erdoğan M
EM
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