title: 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
abstract: Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity.
authors: Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. richard_jelly@yahoo.co.uk
authors: Richard A
authors: RA
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authors: Elliott
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authors: Gibson
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authors: Harrison
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authors: Beher
authors: Earl E
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authors: Clarke
authors: Huw D
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authors: Shearman
authors: Jonathan D J
authors: JD
authors: Wrigley