[Bone morphogenetic proteins and their related molecules in the skeletal tissue].
Biochemical studies revealed bone morphogenetic protein (BMP) receptors and intracelluar Smad proteins that mediate BMP signals. These pathways are regulated extracelluarly by antagonists such as noggin and intracellularly by Smads 6 and 7. Transgenic and conditional knockout mice have been generated and analyzed to clarify function of these molecules in skeletal tissues by using bone- or cartilage-specific promoter sequences.
Tsumaki
Noriyuki
N
Osaka University Graduate School of Medicine, Department of Orthopaedic Surgery.
Yoshikawa
Hideki
H