[Allergic asthma and intrinsic inhibitors of cytokine signaling].
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play an important role in allergic asthma. These cytokines transmit signals through the JAK/STAT and the Ras/ERK signaling pathways, and SOCS family proteins and SPRED family proteins regulate these pathways. SOCS3 controls IL-12-dependent STAT4 activation and Th2 differentiation process. SPRED-1 modulates IL-5-dependent ERK activation and eosinophilia. SOCS3 and SPRED-1 may be targets for therapeutic strategies in allergic asthma.
Inoue
Hiromasa
H
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University. inoue@kokyu.med.kyushu-u.ac.jp