Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines.
Study was made of the 1,3-dipolar cycloaddition of polymer-bound alkynes to azomethine imines generated in situ from N-aminopyridine iodides. Aromatization of the cycloadducts gives polymer-bound pyrazolopyridines that can be released from the resin as carboxylic acids with trifluoroacetic acid or as methyl esters with sodium methoxide.
Harju
Kirsi
K
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Finland.
Kylänlahti
Irene
I
Paananen
Timo
T
Polamo
Mika
M
Nielsen
John
J
Yli-Kauhaluoma
Jari
J