title: Polymorphisms in coding and regulatory regions of the porcine MYF6 and MYOG genes and expression of the MYF6 gene in m. longissimus dorsi versus productive traits in pigs.
abstract: MYOG and MYF6 belong to the MyoD gene family. They code for the bHLH transcription factors playing a key role in later stages of myogenesis: differentiation and maturation of myotubes. Three SNPs in porcine MYF6 and two in porcine MYOG were analysed in order to establish associations with chosen carcass quality and growth rate traits in Polish Landrace, Polish Large White and line 990 sows. No statistically significant effect of SNP in the promoter region of the MYF6 gene on its expression measured on mRNA level was found. Associations between the genotype at the MYF6 locus and carcass quality traits appeared to be breed-dependent. The C allele in the case of SNP in the promoter region and GC haplotype in exon 1 were advantageous for right carcass side weight in Polish Landrace sows and disadvantageous for this trait in Polish Large White sows. These gene variants were also the most advantageous for loin and ham weight in sows of line 990. The mutation in exon 1 of the MYOG gene had no statistically significant association with carcass quality traits and the mutation in the 3'-flanking region had the breed-dependent effect as well. These results suggest that SNPs analysed in this study are not causative mutations, but can be considered as markers of some other, still unrevealed genetic polymorphism that influences the physiological processes and phenotypic traits considered in this study.
authors: Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland. j.wyszynska-koko@ighz.pl
authors: Joanna
authors: J
authors: Wyszyńska-Koko
authors: Mariusz
authors: M
authors: Pierzchała
authors: Krzysztof
authors: K
authors: Flisikowski
authors: Marian
authors: M
authors: Kamyczek
authors: Marian
authors: M
authors: Rózycki
authors: Jolanta
authors: J
authors: Kurył