title: Transcriptional regulation of the human pregnane-X receptor.
abstract: This review addresses the general structure and function of nuclear receptors and places specific emphasis on their role in xenosensing, resulting in the activation of a battery of genes mediating drug metabolism, conjugation, and transport. The pregnane-X receptor is a nuclear receptor that functions to control a battery of genes predominantly involved in drug metabolism and we place emphasis on how this important cellular mediator is transcriptionally activated. We have identified both positive and negative regulatory elements in the PXR promoter, the balance of which dictates the steady state expression of the PXR gene.
authors: University of Surrey, School of Biomedical and Molecular Sciences, Molecular Toxicology Group, England. g.gibson@surrey.ac.uk
authors: G Gordon
authors: GG
authors: Gibson
authors: Anna
authors: A
authors: Phillips
authors: Sihem
authors: S
authors: Aouabdi
authors: Kate
authors: K
authors: Plant
authors: Nick
authors: N
authors: Plant