title: Synthesis and SAR of novel histamine H3 receptor antagonists.
abstract: The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.
authors: Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. jesudason_cynthia_d@lilly.com
authors: Cynthia D
authors: CD
authors: Jesudason
authors: Lisa S
authors: LS
authors: Beavers
authors: Jeffrey W
authors: JW
authors: Cramer
authors: Joelle
authors: J
authors: Dill
authors: Don R
authors: DR
authors: Finley
authors: Craig W
authors: CW
authors: Lindsley
authors: F Craig
authors: FC
authors: Stevens
authors: Robert A
authors: RA
authors: Gadski
authors: Samuel W
authors: SW
authors: Oldham
authors: R Todd
authors: RT
authors: Pickard
authors: Christopher S
authors: CS
authors: Siedem
authors: Dana K
authors: DK
authors: Sindelar
authors: Ajay
authors: A
authors: Singh
authors: Brian M
authors: BM
authors: Watson
authors: Philip A
authors: PA
authors: Hipskind