title: Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs.
abstract: The aim of the present study was to investigate bone formation to recombinant human bone morphogenetic protein-2 (rhBMP-2)-biocoated and rhBMP-2-nonbiocoated titanium implants after implantation in dogs. Implantation of sand-blasted and acid-etched (C), chromosulfuric acid surface-enhanced (CSA), and rhBMP-2-biocoated CSA [BMP-A: noncovalently immobilized rhBMP-2 (596 ng/cm(2)), BMP-B: covalently immobilized rhBMP-2 (819 ng/cm(2))] implants was performed in both the mandible and tibia of dogs. After 4 weeks of healing, the percentage of direct bone to implant contact (BIC) and the induced bone density (BD) at a distance of less than and greater than 1 mm adjacent to each implant was assessed. Histomorphometric analysis of implants inserted in the mandible and tibia revealed that BIC values appeared to be highest in the BMP-B group, followed by BMP-A, CSA, and C. BD as measured at a distance of <1 mm revealed obvious differences between groups: BMP-B>BMP-A>CSA>C. However, no differences between groups were observed at a distance of >1 mm. Within the limits of the present study, it may be concluded that rhBMP-2 immobilized by covalent and noncovalent methods on CSA-treated implant surfaces seemed to be stable and promoted direct bone apposition in a concentration-dependent manner.
authors: Department of Oral Surgery, Westdeutsche Kieferklinik, Heinrich Heine University, 40225, Düsseldorf, Germany. jbecker@uni-duesseldorf.de
authors: Jürgen
authors: J
authors: Becker
authors: Axel
authors: A
authors: Kirsch
authors: Frank
authors: F
authors: Schwarz
authors: Maria
authors: M
authors: Chatzinikolaidou
authors: Daniel
authors: D
authors: Rothamel
authors: Vojislav
authors: V
authors: Lekovic
authors: Markus
authors: M
authors: Laub
authors: Herbert Peter
authors: HP
authors: Jennissen