[The effect of overdose fluoride on the expression of TGF-beta1 in rat's dental pulps].
OBJECTIVE
To observe the effect of overdose fluoride on the expression of TGF-beta1 in rat's dental pulps.


METHODS
20 wister rats were divided into two groups. In the control group, equal dose distilled water were given to the rats. In the experimental group, 20 mg.kg(-1).d(-1) NaF were given. After 8 weeks of treatment, immunohistochemical staining was adopted for detection of the expression of TGF-beta1 in dental pulps of the rats. SPSS10.0 software package was used for Student's t test.


RESULTS
Image analysis results showed that the expression of TGF-beta1 in the dental pulp and inner dentin were inhibited in the experimental group as compared with the control group (P<0.01).


CONCLUSIONS
The overdose fluoride will inhibit the secretion of TGF-beta1, which leads to abnormal development of the teeth.
Wu
Yu
Y
School of Stomatology, Guangxi Medical University, Nanning 530021, Jiangsu Province, China. tongtong419@163.com
He
Ke-xing
KX
Yang
Yi-ping
YP
Cao
Yang
Y
Liang
Zhi-feng
ZF