[Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation].
OBJECTIVE
To search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity.


METHODS
According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.


RESULTS
Four new compounds were obtained and confirmed by spectra.


CONCLUSIONS
Lipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.
Deng
Lan
L
West China School of Pharmacy, Sichuan University, Chengdu 610041, China. denglan234@sina.com
Huang
Heng
H
Xu
Ming-xia
MX