TANGOing along the protein secretion pathway.
Although the organization and functions of the constitutive secretory pathway have been intensively studied for decades, a recent genome-wide RNAi screen in Drosophila cells has identified about 100 genes encoding novel so-called TANGO proteins (for transport and Golgi organization) that may be direct regulators of various aspects of protein exocytosis or secretion.
Rabouille
Catherine
C
University Medical Center Utrecht, The Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. C.Rabouille@lab.azu.nl
Kondylis
Vangelis
V