[A case of hepatitis and pneumonitis caused by Bofutsusyo-san herbal medicine].
We report a case of drug-induced pneumonitis and hepatitis associated with the herbal medication Bofutsusyo-san. A 41-year-old woman was admitted to our hospital with pneumonitis and hepatitis. She complained of fever and dyspnea. Fine crackles were heard on chest auscultation and a chest X-ray film revealed diffuse reticulo-nodular shadow in both lung fields. Cessation of the medication improved the patient' s clinical and X-ray findings. Bronchoalveolar lavage showed an increase of the lymphocytes and a diminished CD4/CD8 ratio. A drug-induced lymphocyte stimulation test was positive. Challenge tests for Bofutsusyo-san were positive. A diagnosis of drug-induced pneumonitis and hepatitis was made. Our findings suggested an association with Ou-gon.
Hatanaka
Nobuyuki
N
Department of Respiratory Medicine, Ohashi Medical Center, Toho University.
Yamagishi
Toru
T
Kamemura
Hirotaka
H
Nakazawa
Ichiro
I
Hirano
Yusuke
Y
Hosaka
Kimio
K
Sanno
Ken
K
Takahashi
Kei
K