Growth and development of children conceived by in-vitro maturation of human oocytes.
OBJECTIVE
The objective of this study is to evaluate the physical and mental development of infants born on in-vitro maturation (IVM) programs.


METHODS
We compare 21 IVM children as study group and 21 non-IVM children as control group. We performed a general physical examination for malformations, neurological examination, developmental examination (Bayley Scales) on the IVM group and the non-IVM group.


RESULTS
We found all the children with normal karyotype and without major malformation in both IVM and non-IVM groups. The mean Mental Development Index scores for IVM subjects and the comparison group were 92.71+/-10.47 and 97.19+/-8.88, respectively (p=0.074). The mean Psychomotor Development Index scores were 96.67+/-8.91 and 96.19+/-7.05, respectively (p=0.817).


CONCLUSIONS
This is the first study designed to evaluate the physical growth and developmental indices of IVM children with combinational priming protocol of FSH and hCG. Our results suggest that IVM children didn't show developmental delay during infancy and early childhood.
Shu-Chi
Mu
M
Institiute of Clinical Medicine, National Yang-Ming University, Medical College of Fu-Jen University, Taiwan.
Jiann-Loung
Hwang
H
Yu-Hung
Lin
L
Tseng-Chen
Sung
S
Ming-I
Lin
L
Tsu-Fuh
Yeh
Y
D001827:Body Height; D001835:Body Weight; D002648:Child; D002657:Child Development / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007361:Intelligence Tests; D008297:Male; D009865:Oocytes / Q000254:growth & development*