[Effect of testosterone concentration on the intensity of 5alpha-dihydrotestosterone and 17beta-oestradiol formation].
The culture of human male foreskin fibroblasts was incubated with various concentrations of testosterone in the medium. It has been shown that the minimum formation of 17beta-oestradiol and 5alpha-dihydrotestosterone occurs at physiological testosterone concentrations. Any deviation of testosterone concentration, both up and down, was accompanied by an increase in the formation of 17beta-oestradiol and 5alpha-dihydrotestosterone.
Pechorskiĭ
A V
AV
Mazurov
V I
VI
Semiglazov
V F
VF
Karpishchenko
A I
AI
Udintsev
A V
AV
D015068:17-Ketosteroids / Q000378:metabolism*; D000732:Androstanols / Q000378:metabolism*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D012867:Skin; D013739:Testosterone / Q000494:pharmacology*
D015068:17-Ketosteroids; C418023:5-dihydrorubrosterone; D000732:Androstanols; D013739:Testosterone; D004958:Estradiol