The molecular mechanisms of classic Hodgkin's lymphoma.
Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitutive NF-kappaB activation and are resistant to apoptosis. This paper reviews several recent studies that for the first time implicate specific molecules in the pathogenesis of classic Hodgkin's lymphoma. Targeting these molecules could lead to the development of novel therapies for this disease.
Felberbaum
Rachael S
RS
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA. rachael.felberbaum@yale.edu
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology* / Q000628:therapy / Q000821:virology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000166:cytology
D016328:NF-kappa B