Effect of Homoharringtonine on corneal haze after excimer laser photorefractive keratectomy in rabbits.
To evaluate the inhibiting effect of Homoharringtonine (HHT) on the corneal haze after excimer laser photorefractive keratectomy (PRK) in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups (A, B and C). The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group. Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C. Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.
Zhang
Mingchang
M
Department of Ophthalmology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
Wang
Li
L
Wang
Yong
Y
Ding
Zhengping
Z
Mai
Caikeng
C
Nie
Shaosong
S
Chen
Fei
F
D000818:Animals; D003318:Corneal Opacity / Q000209:etiology / Q000517:prevention & control*; D004728:Endothelium, Corneal / Q000473:pathology; D006248:Harringtonines / Q000008:administration & dosage*; D000077863:Homoharringtonine; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011817:Rabbits; D011897:Random Allocation
D006248:Harringtonines; D000077863:Homoharringtonine