[The relationship between nuclear-cytoplasmic transport and chromosome segregation].
Chromosomes/chromatids transport to cell division poles (chromosome segregation) and nuclear-cytoplasmic transport give way to each other during cell cycle. Disassembly and reassembly of the nuclear envelope during input or output mitosis are the critical time periods for changing one kind of transport system for the other one. The interest in the problem of relationships between nuclear-cytoplasmic transport and chromosome segregation came into view after revealing some factors involved in both transport systems. Among these factors are GTPase Ran, nuclear transport receptors and associated molecules, kinetochore proteins and proteins of nuclear pore complexes (nucleoprin, for example), spindle microtubules, microtubule motor proteins, and signal molecules. The role of all of these factors in the transport systems is not known. A decision of this problem will make it possible to determine mechanisms of both transport systems and to understand the character of evolutionary relationships between these systems.
Mamon
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D000818:Animals; D001692:Biological Transport; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D020090:Chromosome Segregation; D002875:Chromosomes / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology* / Q000502:physiology*; D018386:Kinetochores / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000502:physiology
D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear; D020931:ran GTP-Binding Protein