title: The genetic basis of premature ovarian failure.
abstract: Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Woad
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Watkins
authors.forename: Deborah
authors.initials: D
authors.lastname: Prendergast
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Shelling
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016649:Primary Ovarian Insufficiency / Q000235:genetics*