Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India.
Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).
Nair
Satheesh
S
The Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom.
Unnikrishnan
Madhulika
M
Turner
Keith
K
Parija
Subash Chandra
SC
Churcher
Carol
C
Wain
John
J
Harish
Narasimha
N
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D007194:India; D009154:Mutation; D012482:Salmonella paratyphi A / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase