title: The effect of acute xerostomia on vocal function.
abstract: OBJECTIVE
  To evaluate whether xerostomia can affect vocal function in an experimental model.
  
  
  METHODS
  Randomized controlled study.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  Twenty healthy young men.
  
  
  METHODS
  Glycopyrrolate was administered to induce acute xerostomia in 10 men, and saline was administered to 10 men who served as controls.
  
  
  METHODS
  Whole salivary flow rate and dry mouth scale were time-serially measured, and subjective and objective vocal functions were checked before and after treatment. The salivary and vocal functions were compared between groups.
  
  
  RESULTS
  Significant salivary hypofunction and symptoms developed within 90 minutes after the administration of glycopyrrolate. Vocal effort and phonation threshold pressure significantly increased (P<.005) and voice range profiles decreased in the xerostomia group (P = .003) but not in the control group. Other voice parameters were comparable between groups (P>.05). High correlations were also found between salivary and vocal parameters.
  
  
  CONCLUSIONS
  Our findings suggest that vocal function can be affected by xerostomia.
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, South Korea. rohjl@amc.seoul.kr
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
authors.forename: Hyo Seon
authors.initials: HS
authors.lastname: Kim
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Kim
mesh_terms: D000328:Adult; D006024:Glycopyrrolate; D006801:Humans; D007830:Larynx / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010699:Phonation / Q000187:drug effects / Q000502:physiology*; D012472:Salivation / Q000187:drug effects / Q000502:physiology; D013018:Sound Spectrography; D013061:Speech Acoustics; D013223:Statistics as Topic; D014833:Voice Quality / Q000187:drug effects / Q000502:physiology*; D014987:Xerostomia / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D006024:Glycopyrrolate