Phenothiazinium-based photobactericidal materials.
Photosensitisers based on the phenothiazinium chromophore have been reported to be bactericidal on illumination via a singlet oxygen-mediated mechanism. The current work reports on the immobilisation of the methylene blue analogue, new methylene blue, in polymer resins, and the preliminary development of photobactericidal materials. The resultant materials exhibited measurable levels of singlet oxygen and were photobactericidal against both Staphylococcus epidermidis and Escherichia coli. Such materials may be of use in surface disinfection/infection control in the healthcare milieu.
Wainwright
Mark
M
Liverpool School of Pharmacy and Chemistry, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK. mark_wainwright@hotmail.com
Byrne
Michael N
MN
Gattrell
Mark A
MA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D004203:Disinfection / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D008751:Methylene Blue / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D010640:Phenothiazines / Q000737:chemistry* / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D001572:Benzofurans; D010640:Phenothiazines; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C035184:new methylene blue; C011238:1,3-diphenylisobenzofuran; D008751:Methylene Blue