Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test.
Changes in plasma antidiuretic hormone (p-ADH) and plasma osmolality (p-Osm) levels were studied in 63 patients with Ménière's disease before and after isosorbide administration and a glycerol test. Increments in both p-ADH and p-Osm levels were observed after isosorbide administration and the glycerol test. The p-ADH secretion appeared to be secondarily stimulated by an increase in the p-Osm level. This p-ADH level increase affects cochlear fluid homeostasis. Based on these results, we must consider both the p-Osm and p-ADH levels when treating patients with Ménière's disease by osmotic diuretics.
Kakigi
Akinobu
A
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. kakigia@med.kochi-u.ac.jp
Takeda
Taizo
T
Sawada
Shoichi
S
Taguchi
Daizo
D
D001301:Audiometry, Pure-Tone; D004234:Diuretics, Osmotic / Q000627:therapeutic use*; D005990:Glycerol; D006801:Humans; D006982:Hypertonic Solutions; D007547:Isosorbide / Q000627:therapeutic use*; D008575:Meniere Disease / Q000188:drug therapy / Q000378:metabolism*; D009994:Osmolar Concentration; D010949:Plasma / Q000378:metabolism*; D014667:Vasopressins / Q000097:blood*
D004234:Diuretics, Osmotic; D006982:Hypertonic Solutions; D014667:Vasopressins; D005990:Glycerol; D007547:Isosorbide