title: Life threatening parvovirus B19 and herpes simplex virus associated acute myocardial dysfunction in a child with homozygous sickle cell disease.
abstract: Human parvovirus (HPV) B19, a common infection, frequently causes transient red cell aplasia in children with hemolytic anemia, such as sickle cell disease (SCD). It was considered to be a self-limited condition, easily treated with blood transfusion. However, acute splenic sequestration, acute chest syndrome, nephrotic syndrome, and stroke have been reported in SCD patients following HPV B19 infection. We report a 3-year-old child with SCD who developed fulminant myocarditis following HPV B19-related aplastic crisis. The diagnosis of myocarditis should be considered in a patient with hemolytic anemia with an infection with HPV B19 who develops signs of cardiopulmonary failure despite correction of anemia.
authors.affiliation: Division of Hematology/Oncology/BMT, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania 15213, USA. krislx@chp.edu
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Krishnamurti
authors.forename: Lizabeth
authors.initials: L
authors.lastname: Lanford
authors.forename: Ricardo
authors.initials: R
authors.lastname: Munoz
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics / Q000628:therapy; D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D017707:Erythrocyte Transfusion / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000150:complications* / Q000276:immunology / Q000821:virology; D006720:Homozygote; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009205:Myocarditis / Q000150:complications* / Q000276:immunology / Q000628:therapy; D010322:Parvoviridae Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M