title: Endoscopy has minimal impact on mortality from upper gastrointestinal cancer in patients older than 55 years with uncomplicated dyspepsia.
abstract: BACKGROUND
  The objective of the study was to determine the effectiveness of endoscopy to detect curable upper gastrointestinal malignancy in patients older than 55 years presenting with uncomplicated dyspepsia.
  
  
  METHODS
  A cohort study was performed in North Glasgow Health Trust. One hundred and thirty-one patients older than 55 years of age, diagnosed to have upper gastrointestinal cancer within the North Glasgow Trust between January 1995 and December 1997, identified by the West of Scotland Cancer Registry were included. The main outcome measures were the proportion of upper gastrointestinal cancers that present in patients older than 55 years with uncomplicated dyspepsia, and the proportion of patients that presented with uncomplicated dyspepsia who have curable upper gastrointestinal cancer.
  
  
  RESULTS
  Of the 131 cancer cases identified, only 30 (23%) had dyspepsia (complicated or uncomplicated) as their predominant symptom and only eight (6%) patients presented with uncomplicated dyspepsia. Of those eight patients presenting with uncomplicated dyspepsia and found to have upper gastrointestinal cancer, six were found to have lymph node metastases and/or extensive metastases at the time of diagnosis. Each of these six patients died from their cancer within 39 months of diagnosis. Of the two patients presenting with uncomplicated dyspepsia without evidence of lymph node spread, one died 55 days after diagnosis. Only one patient presenting with uncomplicated dyspepsia and found to have cancer remains alive at 5-year follow-up.
  
  
  CONCLUSIONS
  Of the 131 patients diagnosed with upper gastrointestinal cancer, only eight presented with uncomplicated dyspepsia and only one of these was cured. Consequently a policy of endoscoping patients older than 55 years with uncomplicated dyspepsia will reduce death from upper gastrointestinal cancers by less than 1% in our population.
authors.affiliation: Division of Cardiovascular & Medical Sciences, Section of Internal Medicine, Endocrinology and Metabolism, Western Infirmary, Glasgow, UK.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Casburn-Jones
authors.forename: Lilian S
authors.initials: LS
authors.lastname: Murray
authors.forename: Derek
authors.initials: D
authors.lastname: Gillen
authors.forename: Kenneth E L
authors.initials: KE
authors.lastname: McColl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004415:Dyspepsia / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000592:standards*; D008875:Middle Aged; D011446:Prospective Studies; D012606:Scotland / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality