Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test.
The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds show that six of them, given intraperitoneally, reduced the immobility time of mice evaluated in the FST, an antidepressant-like profile of action similar to imipramine, a well-known standard antidepressant drug used for comparison, without compromising the animals' motor performance. The putative antidepressant-like action demonstrated here indicates their viability for the development of new therapeutic options for the treatment of depression.
Duarte
Filipe S
FS
Laboratory of Neuropharmacology, Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, 88049-900, Brazil.
Andrade
Evilazio da S
Eda S
Vieira
Ricardo A
RA
Uieara
Marina
M
Nunes
Ricardo J
RJ
de Lima
Thereza C M
TC
D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D007101:Immersion; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D029803:Phyllanthus / Q000737:chemistry; D010881:Piperidones / Q000737:chemistry; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013550:Swimming
D000470:Alkaloids; D000928:Antidepressive Agents; D001388:Aziridines; D010881:Piperidones; D013450:Sulfones; C056680:phyllanthimide; D007099:Imipramine