Towards a vaccine for Cryptococcus neoformans: principles and caveats.
In the Damage-response framework of microbial pathogenesis, infectious diseases are one outcome of a host-microorganism interaction in a susceptible host. In cryptococcal disease, damage to the host is caused by Cryptococcus neoformans virulence determinants, the nature of the host response, or both. Further, the disease may be acute or reactivated from a latent state. Hence, a vaccine for C. neoformans would need to prevent disease resulting from either acute or reactivated infection. The evidence to support the development of a vaccine for C. neoformans that induces antibody-mediated immunity is discussed herein.
Datta
Kausik
K
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pirofski
Liise-anne
LA
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood*; D003453:Cryptococcosis / Q000276:immunology / Q000517:prevention & control*; D003455:Cryptococcus neoformans / Q000276:immunology*; D015195:Drug Design; D005657:Fungal Vaccines / Q000276:immunology*; D006801:Humans; D051379:Mice
D000908:Antibodies, Fungal; D005657:Fungal Vaccines