title: Dedifferentiated mixed stromal-smooth muscle tumor of the uterus. Report of a case.
abstract: So-called dedifferentiation in mesenchymal neoplasms of the uterus is very rare. Among conventional low-grade stromal tumors only three cases of dedifferentiation were reported, whereas in mixed stromal-smooth muscle tumors the dedifferentiation was yet not described. Here we present such a case of low-grade mixed stromal-smooth muscle tumor with dedifferentiation. The tumor occurred in 52-years-old postmenopausal patient. The high-grade component representing a dedifferentiation showed morphology of undifferentiated sarcoma with myxoid change. The low-grade component with morphology of mixed stromal-smooth muscle tumor was limited to a few peripheral areas of the lesion. Immunohistochemically, the low-grade component showed typical positivity for CD10, estrogen receptor, progesterone receptor, and focal reactivity for myoid markers, whereas the dedifferentiated component expressed only vimentin, CD10 and estrogen receptor. This case demonstrates that low-grade mixed stromal-smooth muscle tumor of the uterus can dedifferentiate like a pure stromal tumor. It shows that extensive sampling/histological search may be needed for recognition of a minor component in a dedifferentiated tumor.
authors.affiliation: Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Zámecník
authors.forename: M
authors.initials: M
authors.lastname: Staník
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000473:pathology*; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology*; D018235:Smooth Muscle Tumor / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*