[The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line].
OBJECTIVE
To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.


METHODS
Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.


RESULTS
Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).


CONCLUSIONS
Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.
Lin
Jing-Wen
JW
Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.
Zhou
Hong-Mei
HM
Li
Sheng-Fu
SF
Hu
Tao
T
Chen
Qian-Ming
QM
D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005347:Fibroblasts; D006801:Humans; D009062:Mouth Neoplasms; D014062:Tongue Neoplasms