title: Myocardial infarction caused by Aspergillus embolization in a patient with aplastic anemia.
abstract: A 38-year-old Japanese man with severe aplastic anemia had invasive pulmonary aspergillosis as a complication. He was treated with amphotericin B for six weeks, but the aspergillosis did not improve. Then he experienced a fatal myocardial infarction. An autopsy revealed disseminated aspergillosis involving pericarditis and Aspergillus embolization to the coronary arteries. This led to the acute myocardial infarction. Cardiac aspergillosis is rare, but should be included within the differential diagnosis when chest pain of unknown origin occurs in an immunosuppressed patient.
authors.affiliation: Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Matsushima, Kurashiki.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Itoh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Mori
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tamekiyo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yago
authors.forename: Hideto
authors.initials: H
authors.lastname: Shimada
authors.forename: Kazumori
authors.initials: K
authors.lastname: Arai
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D003327:Coronary Disease / Q000209:etiology; D004617:Embolism / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology*; D010493:Pericarditis / Q000150:complications
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B