title: Gene-enhanced tissue engineering for dental hard tissue regeneration: (1) overview and practical considerations.
abstract: Gene-based therapies for tissue regeneration involve delivering a specific gene to a target tissue with the goal of changing the phenotype or protein expression profile of the recipient cell; the ultimate goal being to form specific tissues required for regeneration. One of the principal advantages of this approach is that it provides for a sustained delivery of physiologic levels of the growth factor of interest.This manuscript will review the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. Part 2 will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration.
authors.affiliation: Creighton University School of Dentistry, Omaha, NE, USA. pedwards@creighton.edu
authors.forename: Paul C
authors.initials: PC
authors.lastname: Edwards
authors.forename: James M
authors.initials: JM
authors.lastname: Mason