Synthesis and Ag(I) complexation studies of tethered westiellamide.
[reaction: see text] A new tethered macrocyclic ring system based on the natural product westiellamide was prepared to increase the affinity and ease of complexation to Ag(I) ions. NMR and fluorescence Ag(I) titrations confirmed that the tethered macrocycles preserve the unique, high-affinity coordination mode of westiellamide.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
Wang
Chenbo
C
D018360:Crystallography, X-Ray; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry
D046911:Macromolecular Substances; D010456:Peptides, Cyclic; C074972:westiellamide; D012834:Silver