title: Electrospinning polydioxanone for biomedical applications.
abstract: Polydioxanone (PDS) is a colorless, crystalline, bioabsorbable polymer that was first developed specifically for wound closure sutures. The compatibility, degradation rate, and mechanical properties (including shape memory) of PDS are of interest when considering the design of tissue engineering scaffolds. This research presents the electrospinning of PDS to fabricate unique nanofibrous structures for a variety of biomedical applications. Electrospinning is a polymer processing technique that utilizes an electric field to form fibers from a polymer solution or melt and allows the fabrication of nanofibrous non-woven structures. Results demonstrate the ability to control the fiber diameter of PDS as a function of solution concentrations and the fiber orientation with our prototype electrospinning apparatus. The results also show dependence between the fiber orientation and the elastic modulus, peak stress, and strain to failure of PDS in a uniaxial model.
authors.affiliation: Department of Biomedical Engineering, Virginia Commonwealth University, P.O. Box 980694, Richmond, VA 23298-0694, USA.
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Boland
authors.forename: Branch D
authors.initials: BD
authors.lastname: Coleman
authors.forename: Catherine P
authors.initials: CP
authors.lastname: Barnes
authors.forename: David G
authors.initials: DG
authors.lastname: Simpson
authors.forename: Gary E
authors.initials: GE
authors.lastname: Wnek
authors.forename: Gary L
authors.initials: GL
authors.lastname: Bowlin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004548:Elasticity; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016687:Polydioxanone / Q000737:chemistry*; D012996:Solutions; D013537:Sutures; D013718:Tensile Strength; D023822:Tissue Engineering; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D012996:Solutions; D016687:Polydioxanone