[Poorly-differentiated thyroid carcinoma: morphological verification and differential diagnosis].
Poorly-differentiated thyroid carcinoma is a stage in the development of anaplastic carcinoma from well-differentiated neoplastic transformation of follicular epithelium. Such tumors differ with respect to histological pattern and age. For instance, patients, aged 50 and more, revealed great nodular size (50-70 mm), marked invasion, large cells with high mitotic index and solid and/or insular pattern. In the group under 40, incapsulated poorly-differentiated tumors were more frequent; they had trabecular histological pattern alone with a much smaller size (ca. 30mm). Further clinico-morphological studies might solve the problem of the connection between cyto- and histological pattern, on the one hand, and clinical course and prognosis, on the other.
Friedman
M V
MV
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*