title: [Comparative analysis of macular hole surgery followed by internal limiting membrane removal with and without indocyanine green staining].
abstract: OBJECTIVE
  To describe comparatively the outcomes of macular hole surgery followed by internal limiting membrane removal with and without indocyanine green staining.
  
  
  METHODS
  We evaluated 142 consecutive macular hole surgeries with internal limiting membrane removal performed in the period from January 2001 to March 2004. These were divided into two groups, based on the use or not of indocyanine green staining.
  
  
  RESULTS
  Both studied groups were similar concerning the patients' profile and preoperative stage of the macular holes. Mean preoperative visual acuity was 0.12+/-0.15 in the group with indocyanine green staining and 0.18+/-0.18 in the group without internal limiting membrane staining (p=0.02). Mean postoperative visual acuity was 0.27+/-0.27 in the group with internal limiting membrane staining and 0.43+/-0.25 in the group without internal limiting membrane staining (p=0.0002). We observed improvement of visual acuity in 63% of cases in the group in which internal limiting membrane staining was performed and in 80.3% of cases in the group without internal limiting membrane staining. Macular hole closure rates were 76.5% in the group treated with internal limiting membrane staining and 95.1% in the group treated without internal limiting membrane staining.
  
  
  CONCLUSIONS
  Macular hole surgeries followed by internal limiting membrane removal without use of staining have better visual and anatomic results when compared to macular hole surgeries followed by internal limiting membrane removal guided by indocyanine green staining. We recommend caution in using indocyanine green staining in macular hole surgeries due to its possible toxic effect.
authors.affiliation: Instituto Brasileiro de Oftalmologia, Rio de Janeiro, RJ, Brazil. ombrasil@uninet.com.br
authors.forename: Oswaldo Moura
authors.initials: OM
authors.lastname: Brasil
authors.forename: Oswaldo Ferreira Moura
authors.initials: OF
authors.lastname: Brasil
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane; D004396:Coloring Agents; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012167:Retinal Perforations / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D013194:Staining and Labeling / Q000379:methods / Q000592:standards; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods / Q000592:standards*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green