title: Catalyst-free conjugated addition of thiols to alpha,beta-unsaturated carbonyl compounds in water.
abstract: [reaction: see text] Catalyst-free conjugate addition of thiols to alpha,beta-unsaturated carbonyl compounds in water is reported. beta-Sulfido carbonyl compounds were formed at room temperature, in short times and with excellent chemoselectivity. Competitive dithiane/dithiolane formation, transesterification, and ester cleavage were not observed. Water played a dual role in simultaneously activating the alpha,beta-unsaturated carbonyl compound and the thiol. This new methodology constitutes an easy, highly efficient, and green synthesis of beta-sulfido carbonyl compounds.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.
authors.forename: Gopal L
authors.initials: GL
authors.lastname: Khatik
authors.forename: Raj
authors.initials: R
authors.lastname: Kumar
authors.forename: Asit K
authors.initials: AK
authors.lastname: Chakraborti