title: [Study on preparation of beta-cyclodextrin inclusion compound for borneolumsyntheticum from Huoxuezhitong capsules].
abstract: OBJECTIVE
  To study the optimum inclusion process of clolloid mill for borneolumsyntheticum from Huoxuezhitong Capsules.
  
  
  METHODS
  The study was carried out with orthogonal design. The borneol content in inclusion complex, the utilization ratio of borneol, and synthesis grading were used as evaluating indicator to review the effects of 3 factors, including the proportion of borneolumsyntheticum to beta-cyclodextrin (mol: mol), milling time and water addition.
  
  
  RESULTS
  The optimum process were borneolumsyntheticum: beta-cyclodextrin was 1:1, the milling time was 40 min, water addition was double.
  
  
  CONCLUSIONS
  The optimum process is feasible, and fit for industrial production, with the advantage of high utilization ratio, shot time and low energy consumption.
authors.affiliation: Nanjing ZhongShan Pharmaceutical Factory Technology Center, Nanjing 210012, China.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Guan
authors.forename: Cun-Hai
authors.initials: CH
authors.lastname: Pu
authors.forename: Kai-Jun
authors.initials: KJ
authors.lastname: Zhao
mesh_terms: D001682:Biological Availability; D001892:Camphanes / Q000032:analysis*; D002214:Capsules; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004337:Drug Carriers; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D009822:Oils, Volatile / Q000032:analysis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014867:Water / Q000008:administration & dosage; D047392:beta-Cyclodextrins
chemical_list: D001892:Camphanes; D002214:Capsules; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; D014867:Water