Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors.
Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently.
Siripurapu
Uma
U
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
Kolanos
Renata
R
Dukat
Małgorzata
M
Roth
Bryan L
BL
Glennon
Richard A
RA
D000840:Anisoles / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D002227:Carbazoles / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D013424:Sulfanilamides / Q000737:chemistry*
D000840:Anisoles; D002227:Carbazoles; D007211:Indoles; D011985:Receptors, Serotonin; D013424:Sulfanilamides; C097216:serotonin 6 receptor; C409925:1,2,3,4-tetrahydrocarbazole; C060998:anisole