Review of pharmacokinetic, pharmacodynamic and clinical studies with a modern combination of amoxicillin/sulbactam.
Amoxicillin/sulbactam is a modern antimicrobial combination. This combination proved to be useful for the treatment of several infections caused by different microorganisms, mainly with the beta-lactamase-producing species. In this review we present the most relevant pharmacokinetic, pharmacodynamic and clinical information associated with its use.
Soutric
J
J
Medical Department, Laboratorios Bagó SA Argentina, Buenos Aires, Argentina. jsoutric@bago.com.ar
Bantar
C
C
Caruso
N
N
Heguilén
R
R
Casellas
J M
JM
Casellas
J M
JM
Farinati
A
A
Jasovich
A
A
Arenoso
H
H
Rodriguez
M
M
D000658:Amoxicillin / Q000493:pharmacokinetics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D013407:Sulbactam / Q000493:pharmacokinetics / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D013407:Sulbactam