Susceptibility to vaginal candidiasis under different conditions in mice.
In order to study the susceptibility of murine vaginal mucosa to Candida albicans under different conditions, vaginal lavage fluid and vaginal tissue of mice were observed and compared between murine models with normal immune system (estrogen-treated mice) and immunosuppressed murine model, and between primary infection model of vaginal candidiasis and secondary infection one. The average level of colony forming unit (CFU) from the immuosuppressed group was higher than that from estrogen-treated group at each time point and the peak time was delayed. The differences between the two groups were statistically significant (P < 0.05) from the fourth day after inoculation. A significant difference existed in the average level of CFU between the control group and the estrogen-treated group (P < 0.05), and between the control group and the immuosuppressed group (P < 0.01). It was concluded that the vaginal mucosa from the immunosuppressed mice is more susceptible to Candida albicans and no difference is found in susceptibility between mice with primary infection and secondary infection.
Tan
Juan
J
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li
Jiawen
J
Chen
Shanjuan
S
Wu
Yan
Y
Qin
Fang T
FT
Ding
Juan
J
Cao
Fei
F
Zhang
Shaoru
S
D000818:Animals; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000209:etiology* / Q000276:immunology*; D004198:Disease Susceptibility; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D016867:Immunocompromised Host; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D014621:Vagina / Q000382:microbiology
D004967:Estrogens