Current prospects for adult stem cell-based therapies in ocular repair and regeneration.
Recent advances in stem cell biology have led to the exploration of stem cell-based therapies to treat a wide range of human diseases. In the ophthalmic field, much hope has been placed on the potential use of these cells to restore sight, particularly in those conditions in which other established treatments have failed and in which visual function has been irreversibly damaged by disease or injury. At present, there are many limitations for the immediate use of embryonic stem cells to treat ocular disease, and as more evidence emerges that adult stem cells are present in the adult human eye, it is clear that these cells may have advantages to develop into feasible therapeutic treatments without the problems associated with embryonic research and immune rejection. Here we discuss the current prospects for the application of various adult ocular stem cells to human therapies for restoration of vision.
Limb
G A
GA
Ocular Repair and Regeneration Biology Unit, Departments of Cell Biology and Pathology, Institute of Ophthalmology, UCL and Moorfields Eye Hospital, 11 Bath Street, London, UK. g.limb@ucl.ac.uk
Daniels
J T
JT
Cambrey
A D
AD
Secker
G A
GA
Shortt
A J
AJ
Lawrence
J M
JM
Khaw
P T
PT
D000328:Adult; D000818:Animals; D003228:Conjunctiva / Q000166:cytology* / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology / Q000637:transplantation; D005128:Eye Diseases / Q000601:surgery*; D006801:Humans; D016850:Limbus Corneae / Q000166:cytology* / Q000502:physiology; D012038:Regeneration; D012160:Retina / Q000166:cytology* / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology