title: Hearing impairment in patients with tuberculosis from Northeast Brazil.
abstract: The aim of this paper is to describe the auditory profile of subjects who were given streptomycin treatment for tuberculosis in the years 2000 and 2001, in Recife, Northeast Brazil. The Injury Notification Database at the Municipal Department of Health was consulted and 78 individuals who had been on streptomycin during the period under study were selected. Forty-two individuals were excluded, of whom five were over 59 years of age and two were under 18 years. Nineteen turned out to be deceased, 13 could not be found, two were serving prison terms and one refused to participate. As a result, only 36 subjects participated in the study. These 36 individuals were interviewed and underwent meatoscopy and audiometry. The mean age of the group under study was 38.8 years old and males predominated (79.4%). Twenty-seven patients (75%) showed hearing impairment, the bilateral sensorineural type (63.9%) being the most frequent, mainly affecting the high frequencies over 4000 Hz. In the light of findings showing a high percentage of hearing impairment complaints among users of streptomycin, this issue seems to warrant an in-depth investigation, as does the implementation of an auditory follow-up routine for patients undergoing such chemotherapy for tuberculosis.
authors.affiliation: Universidade Católica de Pernambuco, Centro de Pesquisas Aggeu Magalhães, FIOCRUZ, Brazil. mluiza@unicap.br
authors.forename: Maria Luiza Lopes Timóteo de
authors.initials: ML
authors.lastname: Lima
authors.forename: Fábio
authors.initials: F
authors.lastname: Lessa
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Aguiar-Santos
authors.forename: Zulma
authors.initials: Z
authors.lastname: Medeiros
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001299:Audiometry; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013307:Streptomycin / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D013307:Streptomycin