An evaluation of the darkroom prone provocative test in family members of primary angle closure glaucoma patients.
OBJECTIVE
To compare ocular biometric parameters with darkroom prone provocative test (DRPPT) in family members of primary angle closure glaucoma (PACG) patients.


METHODS
One hundred and forty-nine family members of 46 PACG patients underwent ocular examination included slit lamp biomicroscopy, gonioscopy, fundus examination using +90 D lens, Goldmann applanation tonometry, darkroom prone provocative test, perimetry on Humphrey's field analyzer II and optic disc evaluation using HRT II. Ultrasonic ocular biometry and the DRPPT were then performed. IOP>or=8 mmHg rise from baseline with iridocorneal touch was considered as a positive test.


RESULTS
Of the 149 family members examined, 55 (36.9%) were found to have PACG. Forty (72.7%) of these had subacute PACG and 15 (27.3%) were found to have chronic PACG. Thirty-nine (70.3%) of the affected members showed a positive DRPPT. Mean anterior chamber depth (ACD) was 2.03+/-0.3, 2.3+/-0.4, 2.7+/-0.3 mm (P=0.0001) and mean lens thickness was 4.41+/-0.39, 3.99+/-0.5, 3.93+/-0.4 mm (P=0.0001) in DRPPT positives, borderlines and negatives respectively. ROC curve (ACD) plotted showed cutoff value of 2.07 mm (sensitivity 88.57%) for screening.


CONCLUSIONS
Anterior chamber is shallowest, lens is thickest and axial length is shortest in affected and DRPPT positive, family members of PACG patients.
Sihota
R
R
Glaucoma Research Lab, Dr. Rajendra Prasad centre for ophthalmic sciences, All India Institute of Medical Sciences, New Delhi, India.
Mohan
S
S
Dada
T
T
Gupta
V
V
Pandey
R M
RM
Ghate
D
D
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D001699:Biometry / Q000379:methods; D002908:Chronic Disease; D003623:Dark Adaptation; D003941:Diagnostic Techniques, Ophthalmological; D005123:Eye / Q000473:pathology; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D016684:Prone Position