title: Prostate cancer detection rate in patients with obstructive voiding symptoms by sextant biopsy: preliminary results.
abstract: To evaluate the effectiveness of a laterally directed sextant biopsy in the group of high volume prostate patients with obstructive voiding symptoms and suspected of prostate cancer. Biopsy was performed in 197 men (age: median 63 years, range 47 to 82 years) because of elevated PSA and/or abnormality in digital rectal examinations (DRE). In most cases, a markedly enlarged prostate was noted: the mean prostate volume was 79,9+/-38,5 cc, and in 73% of the cases, the volume of the prostate was >50 cc. Prostate cancer was diagnosed in 56 of 197 cases (28,4%). The prostate cancer detection rate among patients with a prostate volume of </=50 cc (low volume), 51 to 80 cc (intermediate volume) and >80cc (high volume) were 39,6%, 32,8% and 18,6%, respectively. Our results showed that the laterally directed sextant biopsy with the overall detection rate as high as 28,4% and very low complications is an effective method for the detection of prostate cancer among the suspected patients with obstructive voiding symptoms and markedly enlarged prostates.
authors.affiliation: National Center of Urology, Tbilisi, Georgia.
authors.forename: K
authors.initials: K
authors.lastname: Kiknavelidze
authors.forename: O
authors.initials: O
authors.lastname: Tsintsadze
authors.forename: M
authors.initials: M
authors.lastname: Goguadze
authors.forename: A
authors.initials: A
authors.lastname: Pertia
authors.forename: L
authors.initials: L
authors.lastname: Managadze
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001706:Biopsy; D002939:Ciprofloxacin / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D014524:Urethral Obstruction / Q000175:diagnosis / Q000453:epidemiology*; D014555:Urination Disorders / Q000453:epidemiology*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin