title: Positional nystagmus and vertigo due to a solitary brachium conjunctivum plaque.
abstract: The authors describe two patients suffering from demyelinating central nervous system disease who developed intense vertigo and downbeat nystagmus upon tilting their heads relative to gravity. Brain MRI revealed in both cases a single, small active lesion in the right brachium conjunctivum. The disruption of otolithic signals carried in brachium conjunctivum fibres connecting the fastigial nucleus with the vestibular nuclei is thought to be causatively involved, in agreement with a recently formulated model simulating central positional nystagmus. Insufficient otolithic information results in erroneous adjustment of the Listing's plane in off-vertical head positions, thus producing nystagmic eye movements.
authors.affiliation: Department of Physiology, School of Nursing, University of Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Anagnostou
authors.forename: D
authors.initials: D
authors.lastname: Mandellos
authors.forename: G
authors.initials: G
authors.lastname: Limbitaki
authors.forename: A
authors.initials: A
authors.lastname: Papadimitriou
authors.forename: D
authors.initials: D
authors.lastname: Anastasopoulos
mesh_terms: D000328:Adult; D002526:Cerebellar Diseases / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology; D009760:Nystagmus, Physiologic; D010037:Otolithic Membrane / Q000502:physiology; D014717:Vertigo / Q000209:etiology*