title: Ocular changes with oxaliplatin.
abstract: Ocular toxicity, although uncommon, can occur with many chemotherapeutic agents. Platinum compounds have been documented to produce a variety of ocular side effects, and reports have been made of ocular toxicity with oxaliplatin. This article reports on four patients who experienced ocular symptoms while receiving oxaliplatin. The symptoms included tunnel vision and visual loss with postural changes. One patient had objective findings that included papilledema. All of the changes were reversible. Oxaliplatin will continue to be used widely, so clinicians treating patients with it must be alert for unusual toxicities such as those described in this article.
authors.affiliation: St. Vincent's Comprehensive Cancer Center, New York, NY, USA. dodea@aptiumoncology.com
authors.forename: Denise
authors.initials: D
authors.lastname: O'Dea
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Handy
authors.forename: Ann
authors.initials: A
authors.lastname: Wexler
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D014786:Vision Disorders / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin