Determination of paracetamol: historical evolution.
Paracetamol is a common analgesic and antipyretic drug that is used for the relief of fever, headaches and other minor aches and pains. Their determination in pharmaceuticals is of paramount importance, since an overdose of paracetamol can cause fulminating hepatic necrosis and other toxic effects. Many analytical methodologies have been proposed for the determination of paracetamol. The aim of the present study is to evaluate the utility of different techniques for quantification of paracetamol content in pharmaceutical formulations and biological samples.
Espinosa Bosch
M
M
Department of Analytical Chemistry, Faculty of Sciences, University of Málaga, Campus Teatinos, 29071 Málaga, Spain.
Ruiz Sánchez
A J
AJ
Sánchez Rojas
F
F
Bosch Ojeda
C
C
D000082:Acetaminophen / Q000032:analysis*; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D017022:Flow Injection Analysis; D006801:Humans; D008163:Luminescent Measurements; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared
D000082:Acetaminophen