Should trans fatty acids be viewed as membrane-active drugs?
Trans fatty acids (TFA) can modify cellular function by interacting with hydrophobic regions of membrane proteins. Because these interactions resemble those of pharmacological agents, it might be appropriate to view TFA as drugs.
Katz
Arnold M
AM
The Cardiology Division, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. arnold.katz@dartmouth.edu
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007473:Ion Channels / Q000378:metabolism*; D011485:Protein Binding; D044242:Trans Fatty Acids / Q000378:metabolism*
D007473:Ion Channels; D044242:Trans Fatty Acids