title: Treatment of giant keratoacanthoma with intralesional 5-fluorouracil.
abstract: Giant keratoacanthomas measure greater than 2 cm and have a predilection for the nose and eyelids. As a result, they often present a significant therapeutic challenge. A 36-year old woman was referred for evaluation of a 4.0 x 4.0 cm giant keratoacanthoma on the nose. The patient was treated with intralesional 5-fluorouracil, and the tumor underwent complete regression leaving a full thickness nasal cleft. The defect was then reconstructed with a paramedian forehead flap with good cosmesis.
authors.affiliation: Laser and Skin Surgery Center of Indiana, Carmel, IN 46032, USA.
authors.forename: Aimee L
authors.initials: AL
authors.lastname: Leonard
authors.forename: C William
authors.initials: CW
authors.lastname: Hanke
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005865:Gestational Age; D006801:Humans; D015552:Injections, Intralesional; D007636:Keratoacanthoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011256:Pregnancy Outcome; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods; D016038:Skin Transplantation; D016896:Treatment Outcome
chemical_list: D005472:Fluorouracil