Transcription under the control of nuclear Arm/beta-catenin.
The Wingless/Wnt pathway controls cell fates during animal development and regulates tissue homeostasis as well as stem cell number and differentiation in epithelia. Deregulation of Wnt signaling has been associated with cancer in humans. In the nucleus, the Wingless/Wnt signal is transmitted via the key effector protein Armadillo/beta-catenin. The recent identification and functional analysis of novel Armadillo/beta-catenin interaction partners provide new and exciting insights into the highly complex mechanism of Wingless/Wnt target gene activation.
Städeli
Reto
R
These authors contributed equally. Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Hoffmans
Raymond
R
Basler
Konrad
K
D000818:Animals; D002277:Carcinoma / Q000209:etiology; D002467:Cell Nucleus / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000209:etiology; D005786:Gene Expression Regulation; D008024:Ligands; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D051153:Wnt Proteins / Q000502:physiology; D051176:beta Catenin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D008024:Ligands; D051153:Wnt Proteins; D051176:beta Catenin