title: Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches.
abstract: OBJECTIVE
  The object of this study was to determine the effects of maternal tocolysis with glycerol trinitrate (GTN) patches on the neurodevelopment of infants.
  
  
  METHODS
  This was a randomized, multicenter, controlled trial comparing the efficacy of GTN patches with standard beta2 agonist as tocolytic therapy. The previously reported outcomes of this study indicated no difference in neonatal mortality or morbidity to hospital discharge. One hundred fifty-six surviving infants from 2 Australian centers were psychometrically assessed using the Griffiths Mental development Scales (revised) at 18 months of age.
  
  
  RESULTS
  There was no difference in psychometric performance between those infants enrolled in either the GTN (81 infants) or beta2 agonist (75 infants) arm of the study.
  
  
  CONCLUSIONS
  This randomized trial supports no significant difference between GTN patches in comparison with standard beta2 agonist for tocolytic therapy. The results underscore the association between premature labor and adverse infant outcomes.
authors.affiliation: Mothers and Babies Research Centre, University of Newcastle, Newcastle, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Gill
authors.forename: Gemma
authors.initials: G
authors.lastname: Madsen
authors.forename: Marianna
authors.initials: M
authors.lastname: Knox
authors.forename: Andrew
authors.initials: A
authors.lastname: Bisits
authors.forename: Warwick
authors.initials: W
authors.lastname: Giles
authors.forename: David
authors.initials: D
authors.lastname: Tudehope
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Rogers
authors.forename: Roger
authors.initials: R
authors.lastname: Smith
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D000420:Albuterol / Q000494:pharmacology; D002657:Child Development / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D007360:Intelligence; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011594:Psychometrics; D012312:Ritodrine / Q000494:pharmacology; D015145:Tocolysis / Q000379:methods
chemical_list: D000318:Adrenergic beta-Agonists; D005996:Nitroglycerin; D012312:Ritodrine; D000420:Albuterol