Lobar brain hemorrhages and white matter changes: Clinical, radiological and laboratorial profiles.
BACKGROUND
White matter changes have several histopathologic correlates including cerebral amyloid angiopathy (CAA). The aim of this study was to characterize the clinical, laboratorial and neuroradiological profile of a CAA-related lobar hemorrhages case series.


METHODS
A cohort of 50 consecutive patients with cerebral lobar hemorrhages was studied and clinical, radiological data and ApoE polymorphisms were analyzed. White matter changes were graded and microbleeds were characterized according to number and location using T2* MRI.


RESULTS
A statistically significant association was found between the prestroke cognitive performance and poststroke dementia and between hemorrhage volume and mortality. More severe white matter changes were found in probable CAA when comparing to possible CAA. The most prominent white matter lesions are associated with the presence and the number of microbleeds. The frequency of APOE epsilon 2 and epsilon 4 alleles was higher in this cohort when compared to a Northern Portuguese population.


CONCLUSIONS
White matter changes are frequent in lobar hemorrhage patients and are associated with cortical microbleeds, the radiological hallmark of CAA. Therefore, white matter changes may be the sole phenotype of CAA and, potentially, involved in the pre-stroke cognitive impairment presented by the patients, which are genetically distinct from the population in general.
Maia
Luís F
LF
Department of Neurology, Hospital Geral Santo António, Porto, Portugal.
Vasconcelos
Cristiana
C
Seixas
Susana
S
Magalhães
Rui
R
Correia
Manuel
M
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000235:genetics / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics / Q000473:pathology; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed
D001057:Apolipoproteins E