title: Formal total synthesis of the cytotoxic marine ascidian alkaloid haouamine A.
abstract: [reaction: see text] Described is a convergent 13-step synthesis of a pentacyclic compound which has previously been transformed into haouamine A, therefore constituting a formal total synthesis of this unique marine alkaloid.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA.
authors.forename: Jeannie H
authors.initials: JH
authors.lastname: Jeong
authors.forename: Steven M
authors.initials: SM
authors.lastname: Weinreb
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008386:Marine Biology; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata / Q000737:chemistry*; D000097566:Cyclophanes
chemical_list: D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D008387:Marine Toxins; C474767:haouamine A; D000097566:Cyclophanes