title: The frequency of HLA class I alleles in Japanese patients with bone marrow failure.
abstract: The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6%, p<0.002 and 7.7%, p<0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shichishima
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Noji
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Akutsu
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000741:Anemia, Aplastic / Q000235:genetics / Q000276:immunology / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005787:Gene Frequency; D006457:Hemoglobinuria, Paroxysmal / Q000235:genetics / Q000276:immunology / Q000628:therapy; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007564:Japan; D017211:Treatment Failure
chemical_list: D015395:Histocompatibility Antigens Class I