title: Oral focal epithelial hyperplasia: report of five cases.
abstract: Focal epithelial hyperplasia or Heck's disease is a rare contagious disease caused by human papillomavirus types 13 or 32, initially described among Native American populations. This condition is characterized by the occurrence of multiple small papules or nodules in oral cavity, especially on labial and buccal mucosa and tongue. This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing.
authors.affiliation: Center of Multidisciplinary Support, Federal University of Amazonas, Manaus, AM, Brazil. crisantos@ufam.edu.br
authors.forename: Cristina Maria
authors.initials: CM
authors.lastname: Borborema-Santos
authors.forename: Maria Marta de
authors.initials: MM
authors.lastname: Castro
authors.forename: Paulo José Benevides dos
authors.initials: PJ
authors.lastname: Santos
authors.forename: Sinésio
authors.initials: S
authors.lastname: Talhari
authors.forename: Spartaco
authors.initials: S
authors.lastname: Astolfi-Filho
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000821:virology*; D006801:Humans; D007199:Indians, South American; D008297:Male; D009061:Mouth Mucosa / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA