Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor.
The development of cancerous cells from the normal cells is the consequence of multiple genetic and epigenetic abuses. Activation of "Angiogenic switch" or formation of new blood vessels is one of the upshots of these abuses. Multiple factors are associated with the activation of angiogenic switch. Vascular endothelial growth factor (VEGF) and its down stream signaling molecules is important troupe of this event. In this article, we reviewed the role this troupe in the development of Barrett's adenocarcinoma and also discussed the possible remedies, which have the impact on blocking the function of this troupe.
Islam
Aminul
A
Department of Zoology, K.C. College, Hetampur, Birbhum, West Bengal, India.
Banerjee
Swarnali
S
Kambhampati
Suman
S
Baranda
Joaquina
J
Banerjee
Snigdha
S
Weston
Allan P
AP
Saxena
Neela K
NK
Banerjee
Sushanta K
SK
D000230:Adenocarcinoma / Q000188:drug therapy / Q000503:physiopathology*; D017398:Alternative Splicing; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000188:drug therapy / Q000503:physiopathology*; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology*
D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor