Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
Bauskin
Asne R
AR
Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia. a.bauskin@cfi.unsw.edu.au
Brown
David A
DA
Kuffner
Tamara
T
Johnen
Heiko
H
Luo
X Wei
XW
Hunter
Mark
M
Breit
Samuel N
SN
D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D055436:Growth Differentiation Factor 15; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15