Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria.
The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.
Rice
Sarah E
SE
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Gelfand
Vladimir I
VI
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D029721:Drosophila Proteins; D033681:Mitochondrial Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C470348:milt protein, Drosophila; C504427:Miro protein, Drosophila; D016547:Kinesins; D020741:rho GTP-Binding Proteins