title: Argyrophilic grain disease: case report of the first two cases in the Czech Republic and review of the literature.
abstract: Argyrophilic grain disease (AgD) is a relatively newly described neurodegenerative disease with late-onset dementia. Morphologically it is characterized by the presence of abundant spindle-shaped argyrophilic grains (ArG) in neuronal processes and coiled bodies in oligodendrocytes. ArG consist of abnormally hyperphosphorylated form of tau protein. AgD is a substrate of at least 5% of all dementia cases with increasing incidence in the old age. Here we report the cases of a 91-year-old woman and an 83-year-old man clinically diagnosed with dementia. Neuropathological, histochemical and immunohistochemical examination of the brain tissue show the changes to be compatible with a definite diagnosis of AgD. This is the first description of two cases of AgD in the Czech Republic.
authors.affiliation: Department of Pathology, Working Group for Diagnosis and Study of Neurodegenerative Disorders, Thomayer Teaching Hospital, Prague, Czech Republic. radoslav.matej@ftn.cz
authors.forename: R
authors.initials: R
authors.lastname: Matĕj
authors.forename: F
authors.initials: F
authors.lastname: Koukolík
mesh_terms: D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D016622:Silver Staining; D024801:Tauopathies / Q000473:pathology*