Primary shunt hyperbilirubinaemia in a large four-generation family confirming autosomal dominant genetic disorder.
OBJECTIVE
To describe the pattern of inheritance and confirm the diagnostic criteria of primary shunt hyperbilirubinaemia (PSH).


METHODS
Forty members of a family pedigree across four generations were included in this study. All family members were interviewed and investigated by physical examination, hematology and liver function test and the pattern of inheritance was analyzed.


RESULTS
Nine of the forty family members suffered primary shunt hyperbilirubinaemia. The mature erythrocytes of the propositus were irregular in shape and size. The pedigree showed transmission of the trait through four generations with equal distribution in male and female. No individual with a primary shunt hyperbilirubinaemia was born to unaffected parents. The penetrance was complete in adult.


CONCLUSIONS
The pattern of inheritance is autosomal dominant. The abnormality of erythrocytes and decrease in white blood cell could be supplemented in the diagnosis of PSH. The PSH is a genetic disorder and could by renamed as hereditary shunt hyperbilirubinaemia.
Wang
Chun-Lian
CL
Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Liu
Xiao-Wei
XW
Lu
Fang-Gen
FG
Wu
Xiao-Ping
XP
Ouyang
Chun-Hui
CH
Yang
Dong-Ye
DY
D000328:Adult; D004912:Erythrocytes / Q000473:pathology; D005799:Genes, Dominant / Q000235:genetics; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000175:diagnosis* / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male; D010375:Pedigree