[Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl].
OBJECTIVE
To study the antihyperlipidemia effective constituent of Polygala fallax Hemsl.


METHODS
Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy.


RESULTS
Four triterpenoid saponins were isolated and determined as 3-O-beta-D-glucopyranosyl-( 1--> 2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) -beta-D-fucopyranosyl ester (I), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(3-O-acetyl)-beta-D-fucopyranosyl ester (II), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(4-O-acetyl) -beta-D-fucopyranosyl ester (II) and 3-O-beta-D-glucopyranosyl-(1--2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) - (3,4-diacetyl) -beta-D-fucopyranosyl ester (IV).


CONCLUSIONS
The effective constituents of Polygala fallax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time.
Xu
Kang-Ping
KP
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Huang
Wei
W
Tan
Jian-Bin
JB
Zhou
Ying-Jun
YJ
Li
Fu-Shuang
FS
Huang
Zhao-Hui
ZH
Liu
Bao-Chuan
BC
Tan
Gui-Shan
GS
D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D000960:Hypolipidemic Agents; D012503:Saponins