Under the eye of Nr-CAM.
Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that the cell adhesion molecule Nr-CAM facilitates/promotes the decussation of contralateral axons across the chiasm.
Nguyen-Ba-Charvet
Kim T
KT
CNRS UMR7102, Paris, F-75005, France.
Chédotal
Alain
A
D000818:Animals; D019062:Cell Adhesion Molecules, Neuron-Glia / Q000378:metabolism*; D006801:Humans; D051379:Mice; D015348:Vision, Binocular / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology* / Q000196:embryology* / Q000254:growth & development*
D019062:Cell Adhesion Molecules, Neuron-Glia