title: Clinico-pathological aspects of colorectal serrated adenomas.
abstract: OBJECTIVE
  To study the association of colorectal serrated adenomas (SAs) with invasive carcinoma, local recurrence, synchronicity and metachronicity of lesions.
  
  
  METHODS
  A total of 4,536 polyps from 1,096 patients over an eight-year period (1987-1995) were retrospectively examined. Adenomas showing at least 50% of serrated architecture were called SAs by three reviewing pathologists.
  
  
  RESULTS
  Ninety-one (2%) of all polyps were called SAs, which were found in 46 patients. Invasive carcinomas were seen in 3 out of 46 (6.4%) patients, of whom one was a case of familial adenomatous polyposis (FAP). A male preponderance was noted and features of a mild degree of dysplasia were seen in majority (n=75, 83%) of serrated adenomas. Follow-up ranged 1-12 years with a mean time of 5.75 years. Recurrences of SAs were seen in 3 (6.4%) cases, synchronous SAs in 16 (34.8%) cases and metachronous SAs in 9 (19.6%) cases.
  
  
  CONCLUSIONS
  Invasive carcinoma arising in serrated adenoma is rare, accounting for 2 (4.3%) cases studied in this series.
authors.affiliation: Department of Pathology, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom.
authors.forename: Ashish
authors.initials: A
authors.lastname: Chandra
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Sheikh
authors.forename: Anton
authors.initials: A
authors.lastname: Cerar
authors.forename: Ian C
authors.initials: IC
authors.lastname: Talbot
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies