A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression.
BACKGROUND
To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence.


METHODS
Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103).


RESULTS
Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD.


CONCLUSIONS
These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.
Biederman
Joseph
J
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA. jbiederman@partners.org
Petty
Carter
C
Hirshfeld-Becker
Dina R
DR
Henin
Aude
A
Faraone
Stephen V
SV
Dang
Danielle
D
Jakubowski
Aleksandra
A
Rosenbaum
Jerrold F
JF
D000293:Adolescent; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001010:Anxiety, Separation / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016584:Panic Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D012016:Reference Values; D018570:Risk Assessment; D012917:Social Adjustment