The cellular functions of clathrin.
Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.
Royle
S J
SJ
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. sjr51@mrc-lmb.cam.ac.uk
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D002966:Clathrin / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D022163:Clathrin-Coated Vesicles / Q000502:physiology; D034281:Dynamins / Q000502:physiology; D004705:Endocytosis; D006801:Humans; D008938:Mitosis; D011487:Protein Conformation
D002966:Clathrin; D034281:Dynamins