title: A bioactive titanium foam scaffold for bone repair.
abstract: While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.
authors.affiliation: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Erik D
authors.initials: ED
authors.lastname: Spoerke
authors.forename: Naomi G
authors.initials: NG
authors.lastname: Murray
authors.forename: Huanlong
authors.initials: H
authors.lastname: Li
authors.forename: L Catherine
authors.initials: LC
authors.lastname: Brinson
authors.forename: David C
authors.initials: DC
authors.lastname: Dunand
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Stupp
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000379:methods; D049109:Cell Proliferation; D003198:Computer Simulation; D020342:Finite Element Analysis; D008422:Materials Testing; D051379:Mice; D008954:Models, Biological; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D014025:Titanium