[Acute generalized exanthematous pustulosis with confirmed type IV allergy. Report of 3 cases].
Acute generalized exanthematous pustulosis (AGEP) is characterized by an acute disseminated eruption of multiple, non-follicular pustules. In addition, it can be associated with fever, elevated erythrocyte sedimentation rate, and leukocytosis. The pathogenesis of AGEP is still unknown; however, medications appear a likely cause in most cases. We report on 3 patients with AGEP demonstrating characteristic clinical and histologic features after taking amoxicillin, ampicillin, or diltiazem. All patients had positive patch test reactions to the suspected drugs.
Gensch
K
K
Hautklinik, Heinrich-Heine-Universität Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf. kuhnan@uni-duesseldorf.de
Hodzic-Avdagic
N
N
Megahed
M
M
Ruzicka
T
T
Kuhn
A
A
D000208:Acute Disease; D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects*; D000667:Ampicillin / Q000009:adverse effects*; D004110:Diltiazem / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged
D000667:Ampicillin; D000658:Amoxicillin; D004110:Diltiazem