title: An evaluation of the darkroom prone provocative test in family members of primary angle closure glaucoma patients.
abstract: OBJECTIVE
  To compare ocular biometric parameters with darkroom prone provocative test (DRPPT) in family members of primary angle closure glaucoma (PACG) patients.
  
  
  METHODS
  One hundred and forty-nine family members of 46 PACG patients underwent ocular examination included slit lamp biomicroscopy, gonioscopy, fundus examination using +90 D lens, Goldmann applanation tonometry, darkroom prone provocative test, perimetry on Humphrey's field analyzer II and optic disc evaluation using HRT II. Ultrasonic ocular biometry and the DRPPT were then performed. IOP>or=8 mmHg rise from baseline with iridocorneal touch was considered as a positive test.
  
  
  RESULTS
  Of the 149 family members examined, 55 (36.9%) were found to have PACG. Forty (72.7%) of these had subacute PACG and 15 (27.3%) were found to have chronic PACG. Thirty-nine (70.3%) of the affected members showed a positive DRPPT. Mean anterior chamber depth (ACD) was 2.03+/-0.3, 2.3+/-0.4, 2.7+/-0.3 mm (P=0.0001) and mean lens thickness was 4.41+/-0.39, 3.99+/-0.5, 3.93+/-0.4 mm (P=0.0001) in DRPPT positives, borderlines and negatives respectively. ROC curve (ACD) plotted showed cutoff value of 2.07 mm (sensitivity 88.57%) for screening.
  
  
  CONCLUSIONS
  Anterior chamber is shallowest, lens is thickest and axial length is shortest in affected and DRPPT positive, family members of PACG patients.
authors.affiliation: Glaucoma Research Lab, Dr. Rajendra Prasad centre for ophthalmic sciences, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Sihota
authors.forename: S
authors.initials: S
authors.lastname: Mohan
authors.forename: T
authors.initials: T
authors.lastname: Dada
authors.forename: V
authors.initials: V
authors.lastname: Gupta
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.forename: D
authors.initials: D
authors.lastname: Ghate
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D001699:Biometry / Q000379:methods; D002908:Chronic Disease; D003623:Dark Adaptation; D003941:Diagnostic Techniques, Ophthalmological; D005123:Eye / Q000473:pathology; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D016684:Prone Position