APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.
Reis
Alexandra
A
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle-upon-Tyne, Newcastle, NE2 4HH, UK.
Chang
Heng-Yu
HY
Levasseur
Mark
M
Jones
Keith T
KT
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D049469:Meiotic Prophase I / Q000502:physiology*; D051379:Mice; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism*; D018075:RNA, Complementary / Q000235:genetics; D013997:Time Factors; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D018075:RNA, Complementary; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome