title: Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus.
abstract: From Sarcolobus globosus, two rotenoids (villosinol and 6-oxo-6a,12a-dehydrodeguelin), one isoflavone (genistin) and four phenolic glycosides (vanillic acid 4-O-beta-d-glucoside, glucosyringic acid, tachioside and isotachioside) were identified for the first time from this species. Extracts and compounds from S. globosus were evaluated for their DPPH radical scavenging and 15-lipoxygenase (15-LO) inhibitory activities. All tested rotenoids were found to inhibit 15-LO, while they lacked DPPH radical scavenging effect.
authors.affiliation: Division of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P. O. Box 1068 Blindern, N 0316 Oslo, Norway. helle.wangensteen@farmasi.uio.no
authors.forename: Helle
authors.initials: H
authors.lastname: Wangensteen
authors.forename: Anca
authors.initials: A
authors.lastname: Miron
authors.forename: Mahiuddin
authors.initials: M
authors.lastname: Alamgir
authors.forename: Sultana
authors.initials: S
authors.lastname: Rajia
authors.forename: Anne Berit
authors.initials: AB
authors.lastname: Samuelsen
authors.forename: Karl Egil
authors.initials: KE
authors.lastname: Malterud
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D029062:Apocynaceae; D001093:Arachidonate 15-Lipoxygenase / Q000187:drug effects*; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012402:Rotenone / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D006027:Glycosides; D007529:Isoflavones; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D012402:Rotenone; C004931:1,1-diphenyl-2-picrylhydrazyl; D001093:Arachidonate 15-Lipoxygenase