Convenient direct synthesis of bisformylated calix[4]arenes via ipso substitution.
[reaction: see text] A facile synthesis of bisformylated calix[4]arenes via ipso substitution of p-tert-butylcalix[4]arenes through treatment with hexamethylenetetramine/trifluoroacetic acid is described. Under identical conditions, p-tert-butylcalix[4]arene tetramethyl ether 4 gives proximally substituted bisformylated derivative 4a in a pinched cone conformation.
Chawla
H M
HM
Department of Chemistry, Indian Institute of Technology, Hauz Khas, New Delhi. hmchawla@chemistry.iitd.ernet.in
Pant
N
N
Srivastava
Bindu
B
Upreti
Shailesh
S