title: Predictive factors of acute urinary retention requiring catheterization following 125I prostate brachytherapy.
abstract: OBJECTIVE
  To analyze predictive factors of acute urinary retention requiring catheterization after (125)I prostate brachytherapy.
  
  
  METHODS
  A group of 227 consecutive patients with localized prostate cancer were treated with (125)I prostate brachytherapy between September 2003 and December 2004. The clinical, treatment-related and dosimetric factors were evaluated for the need for catheterization owing to urinary retention.
  
  
  RESULTS
  Twelve patients (5.3%) required catheterization. The median time to onset was 2 days after implantation (range 1-7 days). Univariate analysis demonstrated that pre-implant ultrasound prostate volume, number of seeds, number of needles and neoadjuvant hormonal manipulation were predictive for catheterization. In multivariate analysis, the number of needles and neoadjuvant hormonal manipulation were significant independent predictive factors for catheterization (P = 0.002 and 0.025, respectively). The risk of catheterization in the cluster in which the number of needles was >24 was 4.07 times as high as that in the cluster in which the number of needles was < or =24 [11.3% versus 3.0%, P = 0.020; 95% confidence interval (CI) 1.24-13.36], and the risk in the hormonally manipulated patients was 7.05 times as high as that in the hormone-naïve patients (7.7% versus 1.2%, P = 0.034; 95% CI 0.89-55.64).
  
  
  CONCLUSIONS
  Our data suggest that the number of needles and hormonal manipulation might be the strongest predictors for catheterization.
authors.affiliation: Department of Radiology, Tokyo Medical Center, National Hospital Organization, Meguro-ku, Tokyo 152-8902, Japan. tohashi@ntmc.hosp.go.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohashi
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yorozu
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Toya
authors.forename: Shiro
authors.initials: S
authors.lastname: Saito
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Momma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D001918:Brachytherapy / Q000009:adverse effects*; D005544:Forecasting; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020360:Neoadjuvant Therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D014546:Urinary Catheterization; D016055:Urinary Retention / Q000209:etiology* / Q000628:therapy
chemical_list: D000726:Androgen Antagonists; D007457:Iodine Radioisotopes; D007987:Gonadotropin-Releasing Hormone