title: Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation.
abstract: Vinyl and diene derivatives of thiolactomycin have been prepared via Horner-Wadsworth-Emmons olefination from protected 5-formyl-3,5-dimethylthiotetronic acid. Several 4-position protecting groups and a variety of phosphonates were evaluated, with MOM protection and beta-ketophosphonates yielding the highest ratio of desired product to deformylated product.
authors.affiliation: Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.
authors.forename: Pilho
authors.initials: P
authors.lastname: Kim
authors.forename: Clifton E
authors.initials: CE
authors.lastname: Barry
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Dowd