Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives.
A series of pyridine, pyrane, and pyrimidine derivatives (2-11) were newly synthesized using nitrobenzosuberone 1 as a starting material. The antitumor activities of the synthesized compounds were evaluated utilizing 59 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast, prostate as well as kidney. Some of the tested compounds especially 2, 3, 4c, 6, 7, 9b, 10a, and 11 exhibited better in vitro antitumor activities at low concentration (log(10) GI(50) = -4.7) against the used human tumor cell lines. Additionally, compounds 3, 4c, 6, 7, and 9b were highly selective to inhibit leukemia cell lines. The detailed synthesis, spectroscopic data and antitumor properties for the synthesized compounds were reported.
Amr
Abdel-Galil E
AG
Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt. aamr1963@yahoo.com
Mohamed
Ashraf M
AM
Mohamed
Salwa F
SF
Abdel-Hafez
Nagla A
NA
Hammam
Abu El-Fotooh G
Ael-F
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011714:Pyrans; D011725:Pyridines; D011743:Pyrimidines; C030986:pyrimidine; C023666:pyridine