title: In vitro activities of tinidazole and metronidazole against Clostridium difficile, Prevotella bivia and Bacteroides fragilis.
abstract: Tinidazole, a 5-nitroimidazole similar to metronidazole, was studied against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates. The geometric mean MICs of tinidazole and metronidazole were, respectively: C. difficile, 0.31 and 0.28 microg/mL; P. bivia, 2.33 and 1.52 microg/mL; B. fragilis, 0.5 and 0.71 microg/mL.
authors.affiliation: R.M. Alden Research Laboratory, 2001 Santa Monica Blvd., Suite 685W, Santa Monica, CA 90404, USA. d.m.citron@verizon.net
authors.forename: D M
authors.initials: DM
authors.lastname: Citron
authors.forename: K L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Y A
authors.initials: YA
authors.lastname: Warren
authors.forename: H
authors.initials: H
authors.lastname: Fernandez
authors.forename: C V
authors.initials: CV
authors.lastname: Merriam
authors.forename: E J C
authors.initials: EJ
authors.lastname: Goldstein