title: Survivorship and clinical outcome of modular endoprosthetic reconstruction for neoplastic disease of the lower limb.
abstract: We reviewed retrospectively the results in 211 consecutive patients who had undergone limb salvage for bone neoplasia with endoprosthetic reconstruction of the proximal femur (96), distal femur (78), proximal tibia (30) and total femur (7). Their mean age was 50 years (11 to 86) and the mean follow-up period was 37.3 months (1 to 204). A total of 35 (16.6%) prostheses failed. Overall, implant survival was 78% (95% confidence interval (CI) 0.29 to 0.54) at five years, 60% (95% CI 0.93 to 2.35) at ten years and 60% (95% CI 1.27 to 3.88) at 15 years. Survivorship of the limb was 97.6% (95% CI 1.73 to 3.35) at ten years. The gender, age, diagnosis and location of the tumour were not prognostic variables for failure. Modular endoprosthetic replacement in the lower limb is a durable long-term reconstructive option, with the implants generally outlasting the patient.
authors.affiliation: University of Southern California, Los Angeles, USA. ahlmann2002@yahoo.com
authors.forename: E R
authors.initials: ER
authors.lastname: Ahlmann
authors.forename: L R
authors.initials: LR
authors.lastname: Menendez
authors.forename: C
authors.initials: C
authors.lastname: Kermani
authors.forename: H
authors.initials: H
authors.lastname: Gotha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000379:methods; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery*; D006801:Humans; D007593:Joint Instability / Q000209:etiology; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000150:complications; D012086:Reoperation / Q000379:methods; D012189:Retrospective Studies; D016019:Survival Analysis; D013977:Tibia / Q000601:surgery*; D016896:Treatment Outcome