title: Impact of preoperative steroids administration on ischemia-reperfusion injury and systemic responses in liver surgery: a prospective randomized study.
abstract: Hepatic injury secondary to warm ischemia-reperfusion (I/R) injury and alterations in haemostatic parameters are often unavoidable events after major hepatic resection. The release of inflammatory mediator is believed to play a significant role in the genesis of these events. It has been suggested that preoperative steroid administration may reduce I/R injury and improve several aspects of the surgical stress response. The aim of this prospective randomized study was to investigate the clinical benefits on I/R injury and systemic responses of preoperatively administered corticosteroids. Seventy-six patients undergoing liver resection were randomized either to a steroid group or to a control group. Patients in the steroid group received preoperatively 500 mg of methylprednisolone. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, coagulation parameters, and inflammatory mediators, interleukin 6 and tumor necrosis factor alpha were compared between the 2 groups. Length of stay, and type and number of complications were recorded as well. Postoperative serum levels of ALT, AST, total bilirubin, and inflammatory cytokines were significantly lower in the steroid than in the control group at postoperative days 1 and 2. Changes in hemostatic parameters were also significantly attenuated in the steroid group. In conclusion, the incidence of postoperative complications in the steroid group tended to be significantly lower than the control group. It is of clinical interest that preoperative steroids administration before major surgery may reduce I/R injury, maintain coagulant/anticoagulant homeostasis, and reduce postoperative complications by modulating the inflammatory response.
authors.affiliation: Department of Surgery-Liver Unit, Scientific Institute H San Raffaele, Vita-Salute San Raffaele University, Milano, Italy. aldrighetti.luca@hsr.it
authors.forename: Luca
authors.initials: L
authors.lastname: Aldrighetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Pulitanò
authors.forename: Marcella
authors.initials: M
authors.lastname: Arru
authors.forename: Renato
authors.initials: R
authors.lastname: Finazzi
authors.forename: Marco
authors.initials: M
authors.lastname: Catena
authors.forename: Laura
authors.initials: L
authors.lastname: Soldini
authors.forename: Laura
authors.initials: L
authors.lastname: Comotti
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferla
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000601:surgery*; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D008875:Middle Aged; D015427:Reperfusion Injury / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone