Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity.
CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26-/- mice resulting from targeted inactivation of the gene. These animals had a decreased immobility in the forced swim and tail suspension tests, indicating a reduced depression-like behavior. We addressed some factors that could affect these results. No major differences between mutants and controls were observed in the black/white box test that investigates anxiety. In the hole-board apparatus that explores both curiosity and anxiety, CD26-/- mice of both genders made significantly more head dips than controls. In a motor activity test, mutants displayed higher horizontal and vertical activities i.e. increased novelty-induced behavioral activation. We conclude that DPPIV inactivation in mice broadly leads to an antidepressant-like and hyperactive phenotype.
El Yacoubi
Malika
M
FRE 2735 CNRS, IFRMP 23, UFR de Médecine & Pharmacie, Rouen, France.
Vaugeois
Jean-Marie
JM
Marguet
Didier
D
Sauze
Nicole
N
Guieu
Régis
R
Costentin
Jean
J
Fenouillet
Emmanuel
E
D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000201:enzymology; D001522:Behavior, Animal / Q000502:physiology*; D003863:Depression / Q000201:enzymology; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D046353:Immobility Response, Tonic / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology*
D018819:Dipeptidyl Peptidase 4