A simple, convenient and chemoselective formylation of sterols by Vilsmeier reagent.
Vilsmeier reagent (DMF-POCl(3)) was used as an efficient formylating agent. Several sterols having sec-hydroxyl group at 3/17-position have been modified into respective formate esters. The method is simple, mild, chemoselective and provides sec-alcoholic protection in good yields.
Srivastava
Vandana
V
Central Institute of Medicinal and Aromatic Plants (CIMAP), P.O. CIMAP, Kukrail Road, Lucknow 226 015, India.
Negi
Arvind Singh
AS
Kumar
J K
JK
Gupta
M M
MM
D005563:Formic Acid Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D013261:Sterols / Q000138:chemical synthesis* / Q000737:chemistry
D005563:Formic Acid Esters; D007202:Indicators and Reagents; D013261:Sterols