title: The influence of pH on the G-quadruplex binding selectivity of perylene derivatives.
abstract: Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiangmai 50200, Thailand. wirote@chiangmai.ac.th
authors.forename: Wirote
authors.initials: W
authors.lastname: Tuntiwechapikul
authors.forename: Thanachai
authors.initials: T
authors.lastname: Taka
authors.forename: Mathilde
authors.initials: M
authors.lastname: Béthencourt
authors.forename: Luksana
authors.initials: L
authors.lastname: Makonkawkeyoon
authors.forename: T
authors.initials: T
authors.lastname: Randall Lee
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D017931:DNA Primers; D006147:Guanine / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010569:Perylene / Q000737:chemistry / Q000378:metabolism*
chemical_list: D017931:DNA Primers; D010569:Perylene; D006147:Guanine