HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection.
DNA typing of human lymphocyte antigen (HLA)-dicloro-1-[beta]-D-ribofuranosyl-benzimidazole 1 (DRB1) alleles in 35 individuals serologically positive for T. cruzi and in 41 healthy controls was performed. DRB1*0409 allele was significantly more prevalent in seropositive individuals, with a trend being also observed for the DRB1*0701 and DRB1*1503 alleles. Although statistically insignificant, the latter was found more frequent in cases with cardiomyopathy.
García Borrás
Silvia
S
Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario Suipacha 531, 2000 Rosario, Argentina. sigarcia@fbioyf.unr.edu.ar
Diez
Cristina
C
Cotorruelo
Carlos
C
Pellizon
Oscar
O
Biondi
Claudia
C
Beloscar
Juan
J
Bottasso
Oscar
O
Racca
Amelia
A
D000818:Animals; D001118:Argentina; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014349:Trypanosoma cruzi / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains