title: If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation.
abstract: Recruitment of the NF-kappaB-activating IKK signaling complex to the TNF receptor is shown to be driven by induced binding of NEMO, a regulatory component of this complex, to K63-linked polyubiquitin chains attached to RIP1, a receptor-associated adaptor protein (Ea et al., 2006 [in a recent issue of Molecular Cell]; Li et al., 2006; Wu et al., 2006a).
authors.affiliation: Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kovalenko
authors.forename: David
authors.initials: D
authors.lastname: Wallach
mesh_terms: D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
chemical_list: C119724:AGFG1 protein, human; C491731:IKBKG protein, human; D016328:NF-kappa B; D028861:Nuclear Pore Complex Proteins; D016601:RNA-Binding Proteins; D025801:Ubiquitin; D051550:I-kappa B Kinase