title: [Endoscopic palliation of obstructive jaundice caused by inoperable pancreatic cancer: personal experience].
abstract: OBJECTIVE
  Few patients with pancreatic cancer are eligible for resection. In the remainder, estimation of prognosis is important to optimise various aspects of care, including palliation of biliary obstruction and trial of chemotherapy. The aim is to refer our personal experience about the palliation with endoscopic stenting in patients with unresectable pancreatic cancer.
  
  
  METHODS
  The Authors reviewed retrospectively 132 patients affected by unresectable pancreatic cancer who underwent palliative interventions with endoscopic stenting from 2000 to 2004.
  
  
  RESULTS
  Jaundice dramatically decreased in 86% of patients within 36 hours, in 12% within 48 hours and in 2% after two days. As complication were registered 3% of bleeding after endoscopic sphincterotomy, 2% mild acute post-ERCP pancreatitis and in 7% of patients transitory hyperamylasemia. The most frequent late complication was relapse of jaundice or cholangitis for stent clogging (51%) in a variable range fom 72.3 to 120.7 days, treated with stent substitution. No mortality ERCP-related was registered.
  
  
  CONCLUSIONS
  Resection offers the only potentially curative approach to pancreatic cancer. The majority of patients are either too old, too ill with coexistent disease, or have a tumour that is undoubtedly inappropriate to resect. Thus for the vast majority an endoprosthesis to relieve the jaundice, is the preferred management, after a multidisciplinary approach.
authors.affiliation: Azienda Ospedaliero-Universitaria Policlinico Paolo Giaccone, Dipartimento di Chirurgia d'Urgenza dei Trapianti d'Organo, Sezione di Chirurgia Generale ad Indirizzo Toracico. girgera@tin.it
authors.forename: Girolamo
authors.initials: G
authors.lastname: Geraci
authors.forename: Carmelo
authors.initials: C
authors.lastname: Sciumè
authors.forename: Franco
authors.initials: F
authors.lastname: Pisello
authors.forename: Francesco
authors.initials: F
authors.lastname: Li Volsi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Facella
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Modica
mesh_terms: D000328:Adult; D000368:Aged; D016145:Endoscopy, Digestive System / Q000009:adverse effects; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D016717:Sphincterotomy, Endoscopic; D015607:Stents