title: Recording lead V(4)R is associated to enhanced use of fibrinolytic therapy in acute myocardial infarction.
abstract: BACKGROUND
  ST-segment elevation in the right-sided chest lead V(4)R in inferior wall myocardial infarction is recognized as a sign of proximal occlusion of the right coronary artery with evolving right ventricular myocardial infarction. Our objective is to study how often lead V(4)R is recorded in clinical practice and how this might be associated with use of reperfusion therapy and outcome of patients.
  
  
  METHODS
  Recording of lead V(4)R in 814 consecutive patients with acute myocardial infarction, administration of therapy, and outcome of the patients during a median follow-up of 285 days (174-313 days) were studied.
  
  
  RESULTS
  V(4)R was recorded in 52% of patients with inferior ST-elevation myocardial infarction. Patients with V(4)R recorded were more likely to receive fibrinolytic therapy compared with patients without recording (65% vs 51%; P = .035). In multivariate analysis, recording of lead V(4)R (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.1-2.2; P = .006), along with age (P < .001), previous myocardial infarction (OR 2.2, 95% CI 1.3-3.5; P = .002), and diabetes (OR 3.9, 95% CI 1.1-2.4; P = .03) correlated to the use of reperfusion therapy. Patients with lead V(4)R recorded had less (P = .055) reinfarction, unstable angina, stroke, and/or death during follow-up.
  
  
  CONCLUSIONS
  Lead V(4)R was recorded in only half of patients with inferior ST-elevation myocardial infarction. Patients with V(4)R recorded were more likely to receive thrombolytic therapy than those without recording of the additional chest lead.
authors.affiliation: School of Medicine, University of Tampere, 33520 Tampere, Finland.
authors.forename: Jarkko A
authors.initials: JA
authors.lastname: Harju
authors.forename: Markku J
authors.initials: MJ
authors.lastname: Eskola
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Kari O
authors.initials: KO
authors.lastname: Niemelä
authors.forename: Pekka J
authors.initials: PJ
authors.lastname: Karhunen
authors.forename: Kjell C
authors.initials: KC
authors.lastname: Nikus
mesh_terms: D000368:Aged; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015996:Survival Rate; D015912:Thrombolytic Therapy / Q000379:methods / Q000706:statistics & numerical data*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents