title: The association of serum total sialic acid/total protein ratio with diabetic parameters in young type 1 diabetic patients.
abstract: Sialic acid is a terminal component of the non-reducing end of carbohydrate chains of glycoproteins and glycolipids. The purpose of this study was to estimate serum total sialic acid (TSA) concentrations and serum TSA/serum total protein (TP) ratios in young type 1 diabetic subjects and to investigate their association with diabetes-related parameters in that population. Twentyfour young type 1 diabetic patients and 20 healthy controls were enrolled in this study. Serum TSA and serum TSA/TP ratio were measured in both groups. Moreover, we looked for correlation among serum TSA, serum TSA/TP ratio and clinically relevant parameters such as urinary albumin excretion, blood pressure, diabetes duration, HbA1c, daily insulin dose, serum lipids and magnesium in type 1 diabetic patients. Serum TSA concentrations and serum TSA/TP ratio showed no statistical difference between patients and controls (p>0.05). While serum TSA concentrations only correlated with urinary albumin excretion (r=0.44, p=0.028), serum TSA/TP ratio correlated with diastolic blood pressure (r=0.48, p=0.015), diabetes duration (r=0.46, p=0.022) and urinary albumin excretion (r=0.53, p=0.007) in the diabetic subjects. We concluded that serum TSA/TP ratio might be a better indicator than serum TSA as an index of diabetic complications.
authors.affiliation: Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey. selimk@erciyes.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Kurtoğlu
authors.forename: M E
authors.initials: ME
authors.lastname: Atabek
authors.forename: S
authors.initials: S
authors.lastname: Muhtaroglu
authors.forename: M
authors.initials: M
authors.lastname: Keskin
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002648:Child; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D014280:Triglycerides; D002784:Cholesterol; D019158:N-Acetylneuraminic Acid