title: Localizing moving targets and organs using motion-managed CTs.
abstract: Respiration-induced target and organ motion impacts the radiotherapy strategies of some cancers. Various methods and techniques have been used to investigate motion-related radiotherapy issues, including retrospective 4-dimensional (4D) computed tomography (CT), prospective gated CT, and breath-hold CT scans. This paper reviews these methods and, particularly, the method using retrospective 4D CT scans, which has been developed at our institution. Some motion studies based on retrospective 4D CT images of patients are also examined. These studies have led to reduced planning target volume (PTV) margins for a number of patients, because the respiratory motion was observed to be minimal or gated radiotherapy was used. Respiratory motion managed CTs and, particularly, retrospective 4D CTs are proving to be useful for measuring soft tissue motion, identifying patients who could benefit from gated radiotherapy, and evaluating the effects of respiratory motion during radiotherapy.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. brandnere@upmc.edu
authors.forename: Edward D
authors.initials: ED
authors.lastname: Brandner
authors.forename: Dwight
authors.initials: D
authors.lastname: Heron
authors.forename: Andrew
authors.initials: A
authors.lastname: Wu
authors.forename: M Saiful
authors.initials: MS
authors.lastname: Huq
authors.forename: Ning J
authors.initials: NJ
authors.lastname: Yue
authors.forename: Hungcheng
authors.initials: H
authors.lastname: Chen
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D015656:Respiratory Mechanics; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*