A biophysical basis for the inter-spike interaction of spike-timing-dependent plasticity.
Although spike-timing-dependent plasticity (STDP) is well characterized when pre- and postsynaptic spikes are paired with a given time lag, how this generalizes for more complex spike-trains is unclear. Recent experiments demonstrate that contributions to synaptic plasticity from different spike pairs within a spike train do not add linearly. In the visual cortex conditioning with spike triplets shows that the effect of the first spike pair dominates over the second. Using a previously proposed calcium-dependent plasticity model, we show that short-term synaptic dynamics and interaction between successive back-propagating action potentials (BPAP) may jointly account for the nonlinearities observed. Paired-pulse depression and attenuation of BPAPs are incorporated into the model through the use-dependent depletion of pre- and postsynaptic resources, respectively. Simulations suggest that these processes may play critical roles in determining how STDP operates in the context of natural spike-trains.
Shah
Neel T
NT
Institute for Brain and Neural Systems, Brown University, Providence, RI 02912, USA.
Yeung
Luk Chong
LC
Cooper
Leon N
LN
Cai
Yidao
Y
Shouval
Harel Z
HZ
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002118:Calcium / Q000378:metabolism; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology / Q000528:radiation effects; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011237:Predictive Value of Tests; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors
D002118:Calcium