Upstream toward the "DRiP"-ing source of the MHC class I pathway.
MHC class I binding peptides are generated via cytosolic degradation of a previously undefined substrate. In this issue of Immunity, pre-degradation polypeptide intermediates bound to a cytosolic chaperone is isolated.
Norbury
Christopher C
CC
Department of Microbiology and Immunology, Pennsylvania State University, Milton S. Hershey College of Medicine, Hershey, Pennsylvania 17033, USA.
Tewalt
Eric F
EF
D000818:Animals; D017951:Antigen Presentation; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D010455:Peptides