title: Distribution of the exfoliative toxin D gene in clinical Staphylococcus aureus isolates in France.
abstract: Exfoliative toxin D (ETD) was identified recently as a new exfoliative toxin serotype. Like other exfoliative toxins, ETD induces intra-epidermal cleavage through the granular layer of the epidermis of neonatal mice. The distribution of ETD production was investigated in Staphylococcus aureus isolates from infected and colonised patients in France. The etd gene was found in 55 (10.5%) of 522 isolates tested. Isolates responsible for bullous impetigo and generalised staphylococcal scalded skin syndrome did not harbour etd, but etd was significantly more frequent in isolates causing cutaneous abscesses and furuncles. Most etd- and Panton-Valentine leukocidin-positive strains belonged to the clone of community-acquired methicillin-resistant S. aureus spreading currently throughout France.
authors.affiliation: Centre National de Référence des Staphylocoques, INSERM E0230, IFR62 Faculté de Médecine Laennec, Lyon, France.
authors.forename: O
authors.initials: O
authors.lastname: Yamasaki
authors.forename: A
authors.initials: A
authors.lastname: Tristan
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Sugai
authors.forename: G
authors.initials: G
authors.lastname: Lina
authors.forename: M
authors.initials: M
authors.lastname: Bes
authors.forename: F
authors.initials: F
authors.lastname: Vandenesch
authors.forename: J
authors.initials: J
authors.lastname: Etienne
mesh_terms: D017931:DNA Primers / Q000737:chemistry; D005083:Exfoliatins / Q000235:genetics*; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction / Q000379:methods; D012872:Skin Diseases, Vesiculobullous / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013206:Staphylococcal Scalded Skin Syndrome / Q000382:microbiology; D013211:Staphylococcus aureus / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D017931:DNA Primers; D005083:Exfoliatins