Do mechanical markers of myocardial ischaemia predict the transmural extent of myocardial infarction in man?
BACKGROUND
The present study aimed to explore the relationship between the transmural extent of myocardial necrosis and mechanical markers of myocardial ischaemia in man.


METHODS
A group of 40 patients with previous Q-wave myocardial infarction and a left ventricular ejection fraction (LVEF) of 27 +/- 11% was studied by cine and contrast-enhanced magnetic resonance imaging.


RESULTS
Necrotic areas of delayed contrast enhancement were present in every patient and involved 20 +/- 8% of left ventricular myocardium. In involved segments, the transmural extent of contrast enhancement varied from 5% to 100%, being on average 38 +/- 25% of the wall thickness. End-diastolic left ventricular wall thickness and systolic wall thickening were lower in contrast-enhanced segments than in the other segments (P < 0.001). Furthermore, although left ventricular wall thickness and systolic wall thickening decreased as the transmural extent of contrast enhancement increased, the correlations were weak (r = -0.382 and -0.45, respectively). Finally, a delayed contrast enhancement was present in 89% of akinetic and in 94% of dyskinetic segments; however, contrast enhancement was also present in 18% of the segments with normal wall motion and in 56% of hypokinetic segments.


CONCLUSIONS
Although mechanical markers of myocardial ischaemia substantially reflect the transmural extent of myocardial infarction, none of them can be considered as a substitute for the direct observation of necrotic tissue and its transmural extent, as provided by contrast-enhanced magnetic resonance imaging.
Pingitore
Alessandro
A
CNR Clinical Physiology Institute, Pisa, Italy. pingi@ifc.cnr.it
Rovai
Daniele
D
Positano
Vincenzo
V
Di Bella
Gianluca
G
Strata
Elisabetta
E
De Marchi
Daniele
D
Passera
Mirko
M
Aquaro
Giovanni D
GD
Lombardi
Massimo
M
D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003287:Contrast Media; D004562:Electrocardiography; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009336:Necrosis; D011237:Predictive Value of Tests
D003287:Contrast Media; D019786:Gadolinium DTPA