Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates.
Efflux mechanisms protect bacterial cells by pumping out toxic compounds and actively contribute to bacterial multidrug resistance. Agents inhibiting efflux pumps are of interest for the control of multidrug-resistant bacterial infections. Herein we report the effects of new chloroquinoline derivatives that render resistant Enterobacter aerogenes isolates noticeably more susceptible to structurally unrelated antibiotics. In addition, some of these chloroquinolines increase the intracellular concentration of chloramphenicol. Some of the molecules tested in this work are able to inhibit the main efflux pump (AcrAB-TolC), which is involved in E. aerogenes antibiotic resistance.
Ghisalberti
Didier
D
EA2197, IFR48, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
Mahamoud
Abdallah
A
Chevalier
Jacqueline
J
Baitiche
Milad
M
Martino
Michèle
M
Pagès
Jean-Marie
JM
Barbe
Jacques
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D002701:Chloramphenicol / Q000493:pharmacokinetics; D024881:Drug Resistance, Bacterial; D021902:Enterobacter aerogenes / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
C493251:AcrAB-TolC protein, Salmonella enterica; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D011804:Quinolines; D002701:Chloramphenicol