title: Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice.
abstract: We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrPres may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms.
authors.affiliation: Transmissible Diseases Department, J.H. Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA. cervenakl@usa.redcross.org
authors.forename: Larisa
authors.initials: L
authors.lastname: Cervenakova
authors.forename: Oksana
authors.initials: O
authors.lastname: Yakovleva
authors.forename: Carroll
authors.initials: C
authors.lastname: McKenzie
mesh_terms: D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D009369:Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011328:Prions / Q000378:metabolism*
chemical_list: D011328:Prions; D010447:Peptide Hydrolases