title: Physical functioning: effect of behavioral intervention for symptoms among individuals with cancer.
abstract: BACKGROUND
  Individuals with cancer receiving chemotherapy suffer deterioration in physical functioning due to symptoms arising from the cancer disease process and its treatment.
  
  
  OBJECTIVE
  To determine if age, chronic health conditions (comorbidity), stage of cancer, depressive symptomatology, symptom limitations, sex, and site of cancer moderate the effects of cognitive behavioral intervention on physical function and to determine if symptom limitations mediate the effect of the intervention on physical functioning.
  
  
  METHODS
  Two hundred thirty-seven individuals with solid tumor cancer (118 experimental and 119 control group) participated in this 10-contact, 18-week randomized control trial. Cognitive behavioral theory guided the nurse-delivered problem-solving experimental intervention. The control group received conventional care. Interviews occurred at baseline and 10, 20, and 32 weeks.
  
  
  RESULTS
  Women with breast cancer had significantly better physical functioning than women with lung cancer. Chronic health conditions, symptom limitation, and depressive symptomatology at baseline were found to moderate the effect of intervention on physical function. Symptom limitation, however, was not found to mediate the effect of intervention on physical functioning.
  
  
  CONCLUSIONS
  The intervention was shown to affect physical function trajectories differently for individuals with different personal and health characteristics. Because poor physical functioning is strongly associated with mortality and poor quality of life, this information may be used by health professionals to target interventions to those who might be most responsive.
authors.affiliation: College of Nursing, Michigan State University, East Lansing, Michigan 48824, USA. ardith.doorenbos@hc.msu.edu
authors.forename: Ardith
authors.initials: A
authors.lastname: Doorenbos
authors.forename: Barbara
authors.initials: B
authors.lastname: Given
authors.forename: Charles
authors.initials: C
authors.lastname: Given
authors.forename: Natalya
authors.initials: N
authors.lastname: Verbitsky
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015928:Cognitive Behavioral Therapy; D003866:Depressive Disorder / Q000209:etiology*; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D016294:Models, Nursing; D009369:Neoplasms / Q000150:complications / Q000451:nursing* / Q000523:psychology*; D011788:Quality of Life; D016896:Treatment Outcome