title: [Pathologic features and prognosis of 21 children with isolated proteinuria].
abstract: OBJECTIVE
  To discuss the pathologic features, treatment and prognosis of the children with isolated proteinuria (IP).
  
  
  METHODS
  Twenty-one children with IP were enrolled according to their renal biopsy and were followed up for 0.5 to 10 years.
  
  
  RESULTS
  Renal biopsy was performed in all children. Among them 13 were mesangial proliferation glomerulonephritis (MsPGN) (including 3 minor, 6 moderate, and 4 severe ones), 2 minimal change nephritis (MCN), 3 IgA nephropathy (IgAN) (1 in Grade I and 2 in Grade II), 2 focal segmemtal glomerulosclerosis (FSGS) and 1 endocapillary proliferative glomerulonephritis (EnPGN). Interstitial changes could be found in MsPGN and FSGS mostly, presenting interstitial fibrosis, infiltration of inflammatory cells, atrophy of renal tubule, and the vacuolar degeneration of epithelia. All children accepted the medical treatment except the EnPGN case. Fifteen children recovered with no relapse; proteinuria persisted in 3 severe MsPGN and FSGS cases; 2 got the impaired renal function accompanied by persistent proteinuria; and 1 had hypertension.
  
  
  CONCLUSIONS
  The different degrees of renal damage can be found in all IP children who have persistent proteinuria. Most patients can get good outcome after aggressive therapies. However, the prognosis of those with severe MsPGN and FSGS was not so optimistic, and some reno-protective treatments should be given to postpone the deterioration of the renal function.
authors.affiliation: Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. happydang@tom.com
authors.forename: Xi-qiang
authors.initials: XQ
authors.lastname: Dang
authors.forename: Zhu-wen
authors.initials: ZW
authors.lastname: Yi
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: He
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Bai
authors.forename: Hua-bin
authors.initials: HB
authors.lastname: Yang
authors.forename: Zi-chuan
authors.initials: ZC
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology / Q000473:pathology*