Donepezil effects on cerebral blood flow in older adults with mild cognitive deficits.
Cerebral blood flow (CBF) was assessed during a verbal recall task using [(15)O]water positron emission tomography (PET) in older adults with mild cognitive deficits participating in a placebo-controlled donepezil trial. The placebo group demonstrated reduced CBF in the left frontal and temporal regions over the 6-month period, while those receiving donepezil did not. The placebo group's performance did not change on a list-learning task, while the donepezil group's performance improved, despite having had lower performance at intake. These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning.
Chen
Xiying
X
Department of Radiology, The Roy J. and Lucille A. Carver College of Medicine, 500 Newton Rd., Iowa City, IA 52242-1000, USA.
Magnotta
Vincent A
VA
Duff
Kevin
K
Boles Ponto
Laura L
LL
Schultz
Susan K
SK
D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D004292:Dominance, Cerebral / Q000502:physiology; D000077265:Donepezil; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007189:Indans / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D012039:Regional Blood Flow / Q000187:drug effects
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil