title: X-ray structure of influenza virus NS1 effector domain.
abstract: The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Bornholdt
authors.forename: B V Venkataram
authors.initials: BV
authors.lastname: Prasad
mesh_terms: D018360:Crystallography, X-Ray; D053124:Influenza A Virus, H5N1 Subtype / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D017361:Viral Nonstructural Proteins / Q000737:chemistry*
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins