[Effects of xuefu zhuyu decoction on functions of vascular endothelium in patients with unstable angina pectoris].
OBJECTIVE
To evaluate the effects of Xuefu Zhuyu Decoction (XFZYD) on functions of vascular endothelium in patients with unstable angina pectoris (UAP).


METHODS
Fifty patients with UAP were randomly divided into two groups: XFZYD-treated group with 32 cases and control group with 18 cases. The patients in the control group were given regular therapy, while the patients in the XFZYD-treated group were given XFZYD additionally on the basis of regular therapy. All patients in both groups were treated for 8 weeks. Then the contents of serum endothelin (ET), nitric oxide (NO), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were examined by radioimmunoassay, enzymic method and enzyme-linked immunosorbent assay (ELISA) respectively.


RESULTS
The total response rate in the XFZYD-treated group was 93.75%, which was significantly higher than 66.67% in the control group (P<0.05). The contents of serum ET, sVCAM-1 and sICAM-1 in the XFZYD-treated group were much lower than those in the control group (P<0.01), while the content of serum NO was obviously higher than that in the control group (P<0.01).


CONCLUSIONS
XFZYD can improve the functions of vascular endothelium by lowering the levels of endothelium-derived contracting substances, enhancing the levels of endothelium-derived relaxing substances, and reducing the cell adhesions, and hence to raise the therapeutic effects on UAP.
Wang
Bao-Xiang
BX
Department of Traditional Chinese Medicine, 456th Hospital of People's Liberation Army, Jinan, Shandong Province 250031, China. WBXXiang@163.com
Dong
Xue-Mei
XM
Guo
Ai-Min
AM
Zhang
Jie
J
D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy* / Q000503:physiopathology; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D019010:Vascular Cell Adhesion Molecule-1; D009569:Nitric Oxide