title: Successful chemotherapy for congenital malignant gliomas: a report of two cases.
abstract: We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. A T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.
authors.affiliation: Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan. tamiya@med.kagawa-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Tamiya
authors.forename: Soichiro
authors.initials: S
authors.lastname: Takao
authors.forename: Tomotsugu
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Kosuke
authors.initials: K
authors.lastname: Chayama
authors.forename: Isao
authors.initials: I
authors.lastname: Date
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000151:congenital / Q000175:diagnosis / Q000628:therapy*; D001932:Brain Neoplasms / Q000151:congenital / Q000175:diagnosis / Q000628:therapy*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D005047:Etoposide / Q000008:administration & dosage; D018303:Ganglioglioma / Q000151:congenital / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009607:Nitrosourea Compounds / Q000008:administration & dosage
chemical_list: D009607:Nitrosourea Compounds; D005047:Etoposide; D016190:Carboplatin; C020766:ranimustine