[Therapeutic effects of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers].
OBJECTIVE
To explore the therapeutic effects and mechanisms of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers.


METHODS
One hundred and twenty patients were randomly divided into 6 groups. Another 10 patients as the control group were confirmed with no peptic ulcers by endoscope, but had digestive tract symptoms. The clinical effects were compared among each group after the one month treatment.


RESULTS
The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome (P < 0.01 to 0.05), but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules (P > 0.05). The combination of Jianweiyuyang granules and ranitidine capsules could significantly upregulate the expression of MUCSAC mRNA (P < 0.01), while downregulate the expression of ETAR mRNA (P < 0.01).


CONCLUSIONS
There is obvious advantage in treating peptic ulcers by the combination of Jianweiyuyang granules and ranitidine capsules, and its mechanisms may be to protect the gastric mucosal barrier by up-regulating the expression of MUCSAC mRNA and to improve the gastric mucosal blood flow by down-regulating the expression of ETAR mRNA.
Zhou
Bing
B
Affiliated Hospital of Traditional Chinese Medicine of Hunan Province, Changsha 410006, Changsha 410008, China. zhoubingbing@126.com
Li
Jia-bang
JB
Cai
Guang-xian
GX
Ling
Jiang-hong
JH
Dai
Xing-ping
XP
D000328:Adult; D002214:Capsules; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D019332:Endothelin-1 / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000096:biosynthesis / Q000235:genetics; D010437:Peptic Ulcer / Q000188:drug therapy*; D008517:Phytotherapy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011899:Ranitidine / Q000627:therapeutic use*; D017466:Receptors, Endothelin / Q000096:biosynthesis* / Q000235:genetics
D002214:Capsules; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins; D012333:RNA, Messenger; D017466:Receptors, Endothelin; D011899:Ranitidine