title: Increased extrapyramidal symptoms in patients with schizophrenia and a comorbid substance use disorder.
abstract: Few data have been gathered about the impact of psychoactive substances on extrapyramidal symptoms (EPS) in schizophrenia, and so far, inconsistent results have been reported. We studied 41 outpatients with schizophrenia (based on DSM-IV criteria), who were divided into two groups: with (n = 17) and without (n = 24) a substance use disorder (alcohol, cannabis, and/or cocaine). Both groups were matched for sociodemographic data and psychiatric symptoms (Positive and Negative Syndrome Scale). EPS were evaluated with the Extrapyramidal Symptoms Rating Scale and the Barnes Akathisia Scale, and all patients were stable on either quetiapine or clozapine. Patients receiving anticholinergic drugs were excluded. Analyses of variance were conducted on both groups and showed that schizophrenia patients with a comorbid substance use disorder (especially cocaine) displayed more EPS compared with non-abusing patients.
authors.affiliation: Centre de recherche Fernand-Seguin, Hôpital Louis-H Lafontaine, 7331, rue Hochelaga, Montreal, Quebec, Canada H1N 3V2.
authors.forename: S
authors.initials: S
authors.lastname: Potvin
authors.forename: T
authors.initials: T
authors.lastname: Pampoulova
authors.forename: A
authors.initials: A
authors.lastname: Mancini-Marië
authors.forename: O
authors.initials: O
authors.lastname: Lipp
authors.forename: R-H
authors.initials: RH
authors.lastname: Bouchard
authors.forename: E
authors.initials: E
authors.lastname: Stip
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001480:Basal Ganglia Diseases / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D008297:Male; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D014150:Antipsychotic Agents; D011619:Psychotropic Drugs