[Microdialysis and brain injury: importance of animal study].
Brain microdialysis allows the exploration of brain extracellular medium. This review discusses the main contribution of brain microdialysis for the knowledge of the pathophysiology of brain ischemia and trauma. We describe fundamental principle of microdialysis, limits, and validated metabolic parameters as the lactate/pyruvate ratio or glycerol. The interest to use microdialysis for testing metabolic hypothesis and potential scientific research ways will also be discussed.
Geeraerts
T
T
Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, France. thgeeraerts@hotmail.com
Friggeri
A
A
Vigué
B
B
D000818:Animals; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D017551:Microdialysis