title: Scoliosis in cat cry syndrome.
abstract: BACKGROUND
  Cat cry syndrome is an autosomal disease accompanying abnormal deletion of chromosome 5 and occurs in only 1 of 50,000 neonates. Scoliosis has been reported as a skeletal complication in cat cry syndrome. The characteristics and causes of scoliosis in this rare syndrome are unknown. The purpose of this study was to present the characteristics of scoliosis in cat cry syndrome and to speculate on its causative mechanisms.
  
  
  METHODS
  We report on 11 cases (5 boys and 6 girls) of cat cry syndrome. Detailed investigations of scoliosis, as well as physical and imaging examinations, were performed to characterize scoliosis and its causes. Average age at initial diagnosis of scoliosis was 4.3 years, and average age at final examination was 11.8 years.
  
  
  RESULTS
  The incidence of scoliosis was as high as 73% (8/11). Most cases show a single right thoracic curve. Of the 8 patients with scoliosis, 3 patients who had increased muscular tone showed marked progression of scoliosis with growth.
  
  
  CONCLUSIONS
  Muscular hypertonia may play a key role in the progression of scoliosis in cat cry syndrome.
authors.affiliation: Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Takebayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Obata
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Minaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Sekine
authors.forename: Kenshi
authors.initials: K
authors.lastname: Imoto
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Yokogushi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamashita
mesh_terms: D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012600:Scoliosis / Q000209:etiology* / Q000473:pathology