title: [AP-HM tumour tissue bank: molecular signature of gliomas].
abstract: The AP-HM tissue bank is the largest one in France regarding some collections, including brain tumors. This collection was used to better characterize some gliomas. In particular because some benign gliomas such as pilocytic astrocytomas (WHO grade I) can be misclassified as malignant ones such as glioblastomas (grade IV) the first aim of our study was to find accurate diagnostic markers. This was done mainly by suppressive substractive hybridization (SSH). This study also provides a restrictive list of genes selectively involved in angiogenesis and invasion, which were highly expressed in GBM. Results were confirmed by real time quantitative RT-PCR in a large cohort of patients. In addition in order to find accurate markers which can predict GBM overall survival (OS) we selected three cohorts of GBM patients with distinctive OS (short survival < 6 months, long survival > 18 months and intermediate). Quantification of a series of markers involved in angiogenesis and invasion was done as well as cDNA array analysis.
authors.affiliation: Laboratoire de Biopathologie de l'Adhésion et de la Signalisation, Faculté de Médecine Timone, Marseille, France. dominique.figarella-branger@medecine.univ-mrs.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Carole
authors.initials: C
authors.lastname: Colin
authors.forename: Olivier
authors.initials: O
authors.lastname: Chinot
authors.forename: Isabelle
authors.initials: I
authors.lastname: Nanni
authors.forename: Nathalie
authors.initials: N
authors.lastname: Baeza
authors.forename: Frédéric
authors.initials: F
authors.lastname: Fina
authors.forename: Soutsakhone
authors.initials: S
authors.lastname: Tong
authors.forename: Nathalie
authors.initials: N
authors.lastname: Eudes
authors.forename: Benoit
authors.initials: B
authors.lastname: Quilichini
authors.forename: Sylvie
authors.initials: S
authors.lastname: Romain
authors.forename: Philippe
authors.initials: P
authors.lastname: Metellus
authors.forename: Stéphane
authors.initials: S
authors.lastname: Fuentes
authors.forename: Maryline
authors.initials: M
authors.lastname: Barrié
authors.forename: Céline
authors.initials: C
authors.lastname: Boucard
authors.forename: Caroline
authors.initials: C
authors.lastname: Fraslon
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Bonavita
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Martin
authors.forename: L'Houcine
authors.initials: L
authors.lastname: Ouafik
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D005910:Glioma / Q000235:genetics*; D006801:Humans; D014015:Tissue Banks