New modulated metallic macrocycles: Electrochemistry and their interaction with calf thymus DNA.
New modulated pentacoordinate complexes [C17H34N7O2Cu]ClO4 (5), [C17H34N7O2Co]ClO4 (6), [C17H34N7O2Ni] ClO4 (7) have been synthesized by the interaction of 1,8-dihydro-1,3,6,8,10,13 Cu(II) (2), Co(II) (3), Ni(II) (4) hexaazacyclotetradecane complexes and Hsalea N-(2-hydroxy benzyl)-2-amino-1-ethanol ligand (1). All the complexes have been characterized by infrared, electron paramagnetic resonance, 1H and 13C nuclear magnetic resonance (NMR), 2D correlation spectroscopy NMR and ultraviolet-visible (UV-vis) spectroscopy. In all the complexes, the metal center is encapsulated by the Hsalea ligand in a pentacoordinate environment-vis absorption titration and viscometric studies have been carried out to ascertain the interaction of complexes 5 and 6 with calf thymus DNA (CT DNA). The experimental results suggest that complex 5 binds to CT DNA through partial intercalation of the aromatic ring into the base pair of DNA while complex 6 binds binds to CT DNA by electrostatic mode. The intrinsic binding constants K(b) of complex 5 and 6 were found to be 6.8 x 10(-5) M(-1) and 1.8 x 10(-4) M(-1), respectively. The binding of complexes 5 and 6 with CT DNA has also been investigated by cyclic voltammetry.
Tabassum
Sartaj
S
Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India. tsartaj62@yahoo.com
Parveen
Shaiba
S
Arjmand
Farukh
F
D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D017097:Electric Impedance; D004563:Electrochemistry / Q000379:methods*; D047028:Macrocyclic Compounds / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D008670:Metals / Q000737:chemistry*
D001672:Biocompatible Materials; D047028:Macrocyclic Compounds; D008670:Metals; D004247:DNA; C427203:calf thymus DNA