title: Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease.
abstract: In idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.
authors.affiliation: Department of Neurology, Saarland University, Homburg/Saar, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Spiegel
authors.forename: D
authors.initials: D
authors.lastname: Hellwig
authors.forename: S
authors.initials: S
authors.lastname: Samnick
authors.forename: W
authors.initials: W
authors.lastname: Jost
authors.forename: M-O
authors.initials: MO
authors.lastname: Möllers
authors.forename: K
authors.initials: K
authors.lastname: Fassbender
authors.forename: C-M
authors.initials: CM
authors.lastname: Kirsch
authors.forename: U
authors.initials: U
authors.lastname: Dillmann
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001667:Binding, Competitive / Q000187:drug effects; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011699:Putamen / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D013378:Substantia Nigra / Q000378:metabolism / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014202:Tremor / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D014326:Tropanes / Q000493:pharmacokinetics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine