title: Diabetes prevention: is there more to it than lifestyle changes?
abstract: Over the past years, there has been an explosive increase in the prevalence of type 2 diabetes (T2DM) and this is expected to continue, entailing associated morbidity and mortality. An increasing number of studies explore the different ways T2DM could be prevented. On-going lifestyle modifications need to be addressed. High-risk patients should be given counselling on weight loss, possibly using a low glycaemic index diet, with a target of around 7-10% over 6-12 months, as well as instruction for increasing physical activity to around 150 min of physical exercise weekly (NNT = 4-8). Moderate alcohol consumption and coffee consumption may also be of benefit (NNT = 89 and 66, respectively). Metformin (NNT = 14), acarbose (NNT = 11) and troglitazone (NNT = 6) have been shown to prevent/delay T2DM and angiotensin-converting enzyme (ACE) inhibitors and statins appear to have an adjunctive role (NNT = 42 and 112, respectively). Trials with orlistat and bariatric surgery have also prevented T2DM (NNT = 36 and 6, respectively), and forthcoming treatment with GLP1 mimetics appears promising. Diabetes prevention studies should help create well-defined strategies for screening and treating high-risk populations in the real world, as prevention is our only chance to alleviate the ever growing burden of diabetes mellitus in the world.
authors.affiliation: Sherwood Forest Hospitals NHS Trust, King's Mill Hospital, Sutton-in-Ashfield, Nottinghamshire, UK. agruber@doctors.org.uk
authors.forename: A
authors.initials: A
authors.lastname: Gruber
authors.forename: K
authors.initials: K
authors.lastname: Nasser
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Sharma
authors.forename: G A
authors.initials: GA
authors.lastname: Thomson
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D004032:Diet; D015444:Exercise; D006266:Health Education / Q000458:organization & administration; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style
chemical_list: D007004:Hypoglycemic Agents