The dual nature of neurotrophins.
Neurotrophins are a small family of dimeric secretory proteins in vertebrate neurons with a broad spectrum of functions. They are generated as pro-proteins with a functionality that is distinct from the proteolytically processed form. The cellular responses of neurotrophins are mediated by three different types of receptor proteins, the receptor tyrosine kinases of the Trk family, the neurotrophin receptor p75(NTR), which is a member of the tumor necrosis factor receptor (TNFR) superfamily, and sortilin, previously characterized as neurotensin receptor. Recent studies have revealed an intriguing pattern: neurotrophins can elicit opposing signals utilising their variable configuration and different receptor types.
Schweigreiter
Rüdiger
R
Biocenter Innsbruck, Division of Neurobiochemistry, Medical University Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck Innsbruck, Austria. ruediger.schweigreiter@i-med.ac.at
D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D002470:Cell Survival; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D010641:Phenotype; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism
D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor