Unraveling the pros and cons of interferon-gamma gene regulation.
Although transforming growth factor-beta (TGF-beta) inhibition of interferon-gamma (IFN-gamma) expression has been known for some time, in this issue of Immunity, the crosstalk between proinflammatory cytokine and TGF-beta signaling that regulates IFN-gamma expression is detailed for the first time.
Young
Howard A
HA
Center for Cancer Research, National Cancer Institute, Room 31-93, Building 560, Frederick, Maryland 21702, USA.
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology*; D018664:Interleukin-12 / Q000276:immunology; D020382:Interleukin-18 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D020239:Receptor Cross-Talk / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology
D020382:Interleukin-18; D016212:Transforming Growth Factor beta; D018664:Interleukin-12; D007371:Interferon-gamma