Modeling of gene expression pattern alteration by p,p'-DDE and dieldrin in largemouth bass.
In this study, largemouth bass (LMB) were subchronically exposed to p,p'-DDE or dieldrin in their diet to evaluate the effect of exposure on expression of genes involved in reproduction and steroid homeostasis. Using real-time PCR, we detected a different gene expression pattern for each OCP, suggesting that they each affect LMB in a different way. We also detected a different expression pattern among sexes, suggesting that sexes are affected differently by OCPs perhaps reflecting the different adaptive responses of each sex to dysregulation caused by OCP exposure.
Garcia-Reyero
Natàlia
N
Center for Environmental and Human Toxicology (CEHT), University of Florida, Gainesville, FL 32611, USA.
Barber
David
D
Gross
Timothy
T
Denslow
Nancy
N
D000818:Animals; D001492:Bass / Q000235:genetics* / Q000378:metabolism; D003633:Dichlorodiphenyl Dichloroethylene / Q000633:toxicity*; D004026:Dieldrin / Q000633:toxicity*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling / Q000379:methods; D006066:Gonads / Q000187:drug effects / Q000201:enzymology; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D012737:Sex Factors
D007306:Insecticides; D012333:RNA, Messenger; D003633:Dichlorodiphenyl Dichloroethylene; D004026:Dieldrin