Endothelial function in HIV-infected patients with low or mild cardiovascular risk.
BACKGROUND
Highly active antiretroviral therapy for HIV-infected patients is associated with metabolic side effects, which could cause an increased cardiovascular risk in these patients. Non-invasive study of endothelial function by brachial artery ultrasound can detect subclinical atherosclerosis. Several studies have assessed endothelial function in HIV-infected patients with associated cardiovascular risk factors.


OBJECTIVE
The aim of this study is to determine endothelial function in HIV-infected patients under antiretroviral therapy with low or mild coronary risk and lipid levels within the normal range.


METHODS
Transversal study including 28 HIV-infected adults (15 receiving antiretroviral therapy and 13 naive) with low or mild cardiovascular risk and 12 healthy controls. Subjects with diabetes mellitus, hypertension, cardiovascular disease, obesity, high cholesterol or high triglyceride levels were excluded. Endothelial function was determined with flow-mediated dilation (FMD) of the brachial artery by ultrasound study.


RESULTS
Treated HIV-infected patients had significantly lower FMD (5.93 +/- 3.56) than healthy controls (10.64 +/- 3.08, P = 0.008). Naive patients had an intermediate FMD, but this was not statistically significant.


CONCLUSIONS
HIV-infected patients receiving antiretroviral therapy who have low or mild cardiovascular risk and lipid levels within the normal range have endothelial dysfunction compared with healthy controls.
Blanco
Juan José Ríos
JJ
Department of Internal Medicine, Hospital Universitario La Paz Madrid, Spain. juanjo.rios@gmail.com
García
Inés Suárez
IS
Cerezo
Jorge Gómez
JG
de Rivera
José María Peña Sánchez
JM
Anaya
Pilar Moreno
PM
Raya
Pilar García
PG
García
Juan González
JG
López
José Ramón Arribas
JR
Hernández
Francisco Javier Barbado
FJ
Rodríguez
Juan José Vázquez
JJ
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014664:Vasodilation / Q000187:drug effects
D019380:Anti-HIV Agents