title: Evaluation of the interaction of surfactants with stratum corneum model membrane from Bothrops jararaca by DSC.
abstract: The interaction of surfactants sodium dodecyl sulfate (SDS), cetyl trimethyl ammonium chloride (CTAC) and lauryl alcohol ethoxylated (12 mol ethylene oxide) (LAE-12OE) was evaluated on the stratum corneum (SC) of shed snake skins from Bothrops jararaca, used as model membrane, and thermal characterized by differential scanning calorimetry (DSC). Surfactant solutions were employed above of the critical micellar concentration (CMC) with treatment time of 8h. The SDS interaction with the SC model membrane has increased the characteristic transition temperature of 130 degrees C in approximately 10 degrees C for the water loss and keratin denaturation, indicating an augmentation of the water content. Samples treated with CTAC have a decrease of the water loss temperature, while, for the LAE-12OE treated samples, changes on the transition temperature have not been observed.
authors.affiliation: Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, 580 Prof. Lineu Prestes Av., bloco 13, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil. andrerb@usp.br
authors.forename: André Rolim
authors.initials: AR
authors.lastname: Baby
authors.forename: Aurea Cristina Lemos
authors.initials: AC
authors.lastname: Lacerda
authors.forename: Maria Valéria Robles
authors.initials: MV
authors.lastname: Velasco
authors.forename: Patrícia Santos
authors.initials: PS
authors.lastname: Lopes
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kawano
authors.forename: Telma Mary
authors.initials: TM
authors.lastname: Kaneko
mesh_terms: D000818:Animals; D017837:Bothrops; D002152:Calorimetry, Differential Scanning; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D007851:Dodecanol / Q000737:chemistry; D004817:Epidermis / Q000737:chemistry*; D066298:In Vitro Techniques; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002593:Cetrimonium Compounds; D013501:Surface-Active Agents; D007851:Dodecanol; D012967:Sodium Dodecyl Sulfate; D000077286:Cetrimonium