Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression.
The transcription factor LBP-1c/CP2/LSF (LBP-1c) is a candidate gene for Alzheimer's disease (AD) because it is located in a putative hotspot for an AD risk gene on chromosome 12. We investigated the effect of LBP-1c polymorphism on the risk of AD in 162 AD patients, 180 patients with major depression as hospitalized controls and 225 healthy subjects. We observed no significant association of the LBP-1c A allele with AD. Nor did we detect an interaction of the LBP-1c A allele with the apolipoprotein E4 (ApoE4) allele or the low-density lipoprotein receptor-related protein T allele which could have been related to the risk of AD. However, exploratory data analysis revealed that the LBP-1c A allele might act as a protective factor in major depression. A recent study also described an association of another gene located on chromosome 12, the mannose 6-phosphatase receptor gene, with major depression. These data suggest the presence of a putative risk gene for major depression at chromosome 12.
Schahab
Schamim
S
Department of Psychiatry, University of Bonn, Bonn, Germany.
Heun
Reinhard
R
Schmitz
Sandra
S
Maier
Wolfgang
W
Kölsch
Heike
H
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D017527:Receptor, IGF Type 2 / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D004268:DNA-Binding Proteins; D017527:Receptor, IGF Type 2; D011973:Receptors, LDL; C501906:TFCP2 protein, human; D014157:Transcription Factors; D004247:DNA