title: Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria.
abstract: The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non-malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that beta-hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro. ktatjana@bitsyu.net
authors.forename: Tatjana
authors.initials: T
authors.lastname: Kundaković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stanojković
authors.forename: Zorica
authors.initials: Z
authors.lastname: Juranić
authors.forename: Nada
authors.initials: N
authors.lastname: Kovacević
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D028082:Boraginaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity*; D010835:Phytohemagglutinins / Q000494:pharmacology; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; D010835:Phytohemagglutinins; C005503:naphthazarin