title: Microsatellite diversity in Andhra Pradesh, India: genetic stratification versus social stratification.
abstract: DNA samples of 948 individuals belonging to 27 populations from southern Andhra Pradesh were analyzed for nine AmpFlSTR Profiler Plus loci. The nature and extent of genomic diversity within and between these populations have been examined with reference to socioeconomic and geographic affiliations. The results suggest that the average heterozygosity is uniformly high in these populations (> 0.80) and that the patterns of allele distributions are similar across the populations. The value of the coefficient of gene differentiation and the AMOVA and structure analysis results suggest that these populations are highly homogeneous. The neighbor-joining tree constructed using either D(A) or F(ST) distances suggests no intelligible pattern of population clusters based on ethnohistoric or geographic affiliations. All these observations suggest either a common recent origin of these populations or extensive gene flow across the populations that erased the original genetic differences. Given strict endogamy, the latter explanation can hold only if there has been unauthorized or unrecognized gene flow transecting the social boundaries. Nevertheless, the regression plot of average heterozygosity versus distance from the centroid (Rii), based on Harpending and Ward's (1982) model, and the genetic distances computed between different hierarchical groups within Andhra Pradesh tend to support this conjecture. Overall, the results suggest lack of a significant degree of genetic stratification that is consistent with social stratification in Andhra Pradesh. Furthermore, the neighbor-joining tree based on comparative data from other Indian and continental populations brings out a single and compact cluster of all the Andhra populations that is clearly separated from the rest.
authors.affiliation: Biological Anthropology Unit, Indian Statistical Institute, Street No. 8, Habsiguda, Hyderabad 500 007, India.
authors.forename: B Mohan
authors.initials: BM
authors.lastname: Reddy
authors.forename: V M
authors.initials: VM
authors.lastname: Naidu
authors.forename: V Komal
authors.initials: VK
authors.lastname: Madhavi
authors.forename: L K
authors.initials: LK
authors.lastname: Thangaraj
authors.forename: Vikrant
authors.initials: V
authors.lastname: Kumar
authors.forename: B T
authors.initials: BT
authors.lastname: Langstieh
authors.forename: P
authors.initials: P
authors.lastname: Venkatramana
authors.forename: A G
authors.initials: AG
authors.lastname: Reddy
authors.forename: Lalji
authors.initials: L
authors.lastname: Singh
mesh_terms: D000483:Alleles; D051456:Gene Flow; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007194:India; D018895:Microsatellite Repeats; D012923:Social Class; D012959:Socioeconomic Factors
chemical_list: D005819:Genetic Markers