A Japanese case of familial Mediterranean fever with onset in the fifties.
The patient was a 63-year-old woman with attacks of fever and abdominal pain, starting from the age of 53 years and recurring every month. Despite various examinations at another hospital, the etiology remained unclear. She was under symptomatic treatment, and was referred to our department for further evaluation. Although she had onset in middle age, the clinical symptoms and examination findings suggested familial Mediterranean fever, and administration of colchitine inhibited the attacks completely. Therefore, the patient was diagnosed as having the disease. We were not able to analyze the entire MEFV gene, but detected only a heterozygous M694I mutation. Amyloidosis did not develop as a complication. The disease is rare in Japan, and its onset in the fifties is extremely rare in the world.
Yamane
Tateki
T
Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Kashiwashita, Chiba.
Uchiyama
Kan
K
Hata
Daigo
D
Nakamura
Makoto
M
Ishii
Takayuki
T
Koido
Shigeo
S
Fujise
Kiyotaka
K
Tajiri
Hisao
H
D015746:Abdominal Pain / Q000150:complications; D017668:Age of Onset; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000150:complications; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged