title: Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation.
abstract: Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade. In the present study, domestic cats were intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The intoxicated animals presented emesis, diarrhea with abdominal pain posture and an abdominal palpation, tachypnea, bilateral midriasis, hypothermia, hyperexcitability and convulsions. Blood gas analysis indicated decreased pH and bicarbonate levels. Serum ionized calcium was also decreased. ECG showed non-specific changes in ventricular repolarization and ventricular arrhythmias. The survival rate was 75% in the treated group with calcium gluconate and sodium succinate and 37.5% in the nontreated group.
authors.affiliation: Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the São Paulo State University - UNESP, Botucatu, Brazil. ritacollizuanaze@yahoo.com.br
authors.forename: R C
authors.initials: RC
authors.lastname: Collicchio-Zuanaze
authors.forename: M
authors.initials: M
authors.lastname: Sakate
authors.forename: D S
authors.initials: DS
authors.lastname: Schwartz
authors.forename: E
authors.initials: E
authors.lastname: Trezza
authors.forename: A J
authors.initials: AJ
authors.lastname: Crocci
mesh_terms: D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D001784:Blood Gas Analysis; D002118:Calcium / Q000097:blood; D002125:Calcium Gluconate / Q000008:administration & dosage / Q000627:therapeutic use*; D002415:Cats; D002626:Chemistry, Pharmaceutical; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005463:Fluoroacetates / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D019802:Succinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000931:Antidotes; D005463:Fluoroacetates; D019802:Succinic Acid; C014815:fluoroacetic acid; D002125:Calcium Gluconate; D002118:Calcium