title: Acute myeloid leukemia with pseudo-Chèdiak-Higashi anomaly exhibits a specific immunophenotype with CD2 expression.
abstract: Acute myeloid leukemia (AML) with pseudo-Chèdiak-Higashi (PCH) anomaly is a rare morphologic entity. We characterized 5 cases by multiparameter flow cytometry and found that in all cases, the blasts aberrantly expressed CD2, a pan-T cell-associated marker, in addition to their myeloid-associated markers. In contrast, CD2 was expressed in only 25 (17.9%) of 140 cases of newly diagnosed AML without PCH anomaly. CD2 expression correlated strongly with AML with PCH anomaly (P < .01), suggesting a link between a specific immunophenotypic marker, CD2, and AML with PCH anomaly.
authors.affiliation: Department of Laboratory Hematology, Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, 610 University Avenue 4-320, Toronto, Ontario, Canada.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.forename: Qi Long
authors.initials: QL
authors.lastname: Yi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D018801:CD2 Antigens / Q000378:metabolism*; D002609:Chediak-Higashi Syndrome / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D018801:CD2 Antigens