Transcriptional regulation of neurogenesis in the olfactory epithelium.
1. The olfactory epithelium (OE) is a simple structure that gives rise to olfactory sensory neurons (OSNs) throughout life. 2. Numerous transcription factors (TFs) are expressed in regions of the OE which contain progenitor cells and OSNs. The function of some of these TFs in OSN development has been elucidated with the aide of transgenic knockout mice. 3. We review here the current state of knowledge on the role of TFs in OE neurogenesis and relate the expression of these TFs, where possible, to the well-documented phenotype of the cells as they progress through the OSN lineage from progenitor cells to mature neurons.
Nicolay
Danette J
DJ
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, 116 Thorvaldson Building, 110 Science Place, Saskatoon, Saskatchewan, Canada S7N 5C9.
Doucette
J Ronald
JR
Nazarali
Adil J
AJ
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological; D009475:Neurons, Afferent / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000196:embryology* / Q000294:innervation*; D038081:Organogenesis; D013234:Stem Cells / Q000502:physiology; D014158:Transcription, Genetic