title: Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus.
abstract: The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
authors.affiliation: Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri-Columbia, 65212, USA.
authors.forename: Phullara B
authors.initials: PB
authors.lastname: Shelat
authors.forename: Aminata P
authors.initials: AP
authors.lastname: Coulibaly
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Albert Y
authors.initials: AY
authors.lastname: Sun
authors.forename: Grace Y
authors.initials: GY
authors.lastname: Sun
authors.forename: Agnes
authors.initials: A
authors.lastname: Simonyi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D020710:RGS Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*
chemical_list: D020710:RGS Proteins; D012333:RNA, Messenger