title: [Cannabis and road crashes: a survey of recent French studies].
abstract: The clarification of the mechanisms of action of cannabis and its effects on motor and cognitive functions, the results of previous studies performed on driving simulators and closed or open-road driving trials, are important criteria for highlighting the increased risk of road crashes for drivers after a recent use of cannabis. In addition epidemiological studies allow to measure the magnitude of the problem. A survey of French epidemiological studies performed from 1999 to 2004, as well as the data of THC distribution in tissues studies performed on man and animal allowed us to draw a number of conclusions. The risk of road crash after a recent use of cannabis is increased by more than 2.4 in all studies. The prevalence of cannabis use in drivers involved in a road crash has dramatically increased during the last years. For methodological reasons (a too high threshold for THC positivity, a too long time delay between accident and blood sampling), the annual number of fatal cases induced by a cannabis use was likely underestimated. This assessment is consistent with recent data which indicate that THC could be still present in brain while absent in blood. A positivity threshold for THC in blood of 0.5 ng/mL would be more appropriated. So, all recent French studies highlighted that a recent use of cannabis impairs driving ability and that it would be advisable to intensify roadside testing for drugs of abuse.
authors.affiliation: Centre hospitalier universitaire de Poitiers, Service de toxicologie et pharmacocinétique, Chu, BP 577, F 86021 Poitiers Cedex.
authors.forename: P
authors.initials: P
authors.lastname: Mura
authors.forename: B
authors.initials: B
authors.lastname: Brunet
authors.forename: F
authors.initials: F
authors.lastname: Favreau
authors.forename: T
authors.initials: T
authors.lastname: Hauet
mesh_terms: D000063:Accidents, Traffic / Q000706:statistics & numerical data*; D001334:Automobile Driving; D002188:Cannabis / Q000009:adverse effects*; D005602:France / Q000453:epidemiology; D006801:Humans; D008385:Marijuana Smoking / Q000009:adverse effects / Q000453:epidemiology