Can a genome change its (hot)spots?
A new study by Jeffreys et al. shows that the rate of recombination in recombination hotspots in humans is not constant through time. This observation adds weight to the idea that hotspots are transient on evolutionary timescales. However, questions remain as to what controls their evolution and how these rapid changes influence broad-scale rates of recombination.
Coop
Graham
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Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 505, Chicago, IL 60637, USA. gcoop@bsd.uchicago.edu