title: Effect of Homoharringtonine on corneal haze after excimer laser photorefractive keratectomy in rabbits.
abstract: To evaluate the inhibiting effect of Homoharringtonine (HHT) on the corneal haze after excimer laser photorefractive keratectomy (PRK) in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups (A, B and C). The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group. Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C. Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.
authors.affiliation: Department of Ophthalmology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Mingchang
authors.initials: M
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Ding
authors.forename: Caikeng
authors.initials: C
authors.lastname: Mai
authors.forename: Shaosong
authors.initials: S
authors.lastname: Nie
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
mesh_terms: D000818:Animals; D003318:Corneal Opacity / Q000209:etiology / Q000517:prevention & control*; D004728:Endothelium, Corneal / Q000473:pathology; D006248:Harringtonines / Q000008:administration & dosage*; D000077863:Homoharringtonine; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011817:Rabbits; D011897:Random Allocation
chemical_list: D006248:Harringtonines; D000077863:Homoharringtonine