The impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study.
BACKGROUND
The aim of this prospective randomized study was to investigate the necessity and impact of prophylactic antibiotics on postoperative infection complications in elective laparoscopic cholecystectomy.


METHODS
At the time of induction of anesthesia, group A patients (n = 141) received 1 g cefazolin, and group B patients (control; n = 136) received 10 mL isotonic sodium chloride solution. Patients' characteristics and general operative outcomes were compared and analyzed.


RESULTS
The overall rate of infection was 1.1% for total 277 patients (0.7% for group A patients and 1.5% for group B patients). No significant difference in infection complications was found between these 2 groups. Also any risk factors contributing to infection complications could not be found.


CONCLUSIONS
We do not recommend the use of prophylactic antibiotics in elective laparoscopic cholecystectomy because they will not decrease the already-low rate of postoperative infectious complications.
Chang
Wen-Tsan
WT
Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Taiwan.
Lee
King-Teh
KT
Chuang
Shih-Chang
SC
Wang
Shen-Nien
SN
Kuo
Kung-Kai
KK
Chen
Jong-Shyone
JS
Sheen
Pai-Ching
PC
D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
D002437:Cefazolin