Significant absorption of oral vancomycin in a patient with clostridium difficile colitis and normal renal function.
Orally-administered vancomycin is poorly absorbed in most patients, usually producing minimal or subtherapeutic serum concentrations. Bowel inflammation may enhance absorption of oral vancomycin, particularly in those with renal failure. A 77-year-old female with Clostridium difficile (C difficile) colitis and normal renal function was treated with high doses of oral vancomycin and achieved serum concentrations in the therapeutic range. To our knowledge, this is the first report of a patient with C difficile colitis and normal renal function to develop therapeutic serum concentrations following oral administration of vancomycin.
Aradhyula
Sangita
S
Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO 63141, USA.
Manian
Farrin A
FA
Hafidh
Saad A S
SA
Bhutto
Saqib S
SS
Alpert
Martin A
MA
D000042:Absorption; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003092:Colitis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology*; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology; D014640:Vancomycin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin