title: APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
abstract: Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.
authors.affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle-upon-Tyne, Newcastle, NE2 4HH, UK.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Reis
authors.forename: Heng-Yu
authors.initials: HY
authors.lastname: Chang
authors.forename: Mark
authors.initials: M
authors.lastname: Levasseur
authors.forename: Keith T
authors.initials: KT
authors.lastname: Jones
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D049469:Meiotic Prophase I / Q000502:physiology*; D051379:Mice; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism*; D018075:RNA, Complementary / Q000235:genetics; D013997:Time Factors; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
chemical_list: D018075:RNA, Complementary; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome