title: A 3D computational simulation of fracture callus formation: influence of the stiffness of the external fixator.
abstract: The stiffness of the external fixation highly influences the fracture healing pattern. In this work we study this aspect by means of a finite element model of a simple transverse mid-diaphyseal fracture of an ovine metatarsus fixed with a bilateral external fixator. In order to simulate the regenerative process, a previously developed mechanobiological model of bone fracture healing was implemented in three dimensions. This model is able to simulate tissue differentiation, bone regeneration, and callus growth. A physiological load of 500 N was applied and three different stiffnesses of the external fixator were simulated (2300, 1725, and 1150 N/mm). The interfragmentary strain and load sharing mechanism between bone and the external fixator were compared to those recorded in previous experimental works. The effects of the stiffness on the callus shape and tissue distributions in the fracture site were also analyzed. We predicted that a lower stiffness of the fixator delays fracture healing and causes a larger callus, in correspondence to well-documented clinical observations.
authors.affiliation: Group of Structural Mechanics and Materials Modelling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, María de Luna 3, 50008, Zaragoza, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez-Benito
authors.forename: J M
authors.initials: JM
authors.lastname: García-Aznar
authors.forename: J H
authors.initials: JH
authors.lastname: Kuiper
authors.forename: M
authors.initials: M
authors.lastname: Doblaré
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000503:physiopathology*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004548:Elasticity; D019544:Equipment Failure Analysis; D016267:External Fixators; D005592:Fracture Fixation / Q000295:instrumentation* / Q000379:methods; D017102:Fracture Healing / Q000502:physiology*; D050723:Fractures, Bone / Q000503:physiopathology* / Q000601:surgery*; D040542:Mechanotransduction, Cellular; D008682:Metatarsal Bones / Q000293:injuries / Q000503:physiopathology; D008954:Models, Biological; D011474:Prosthesis Design; D012756:Sheep; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome