In vitro activity of 11 antibiotics against 74 anaerobes isolated from pediatric intra-abdominal infections.
The in vitro activity of 11 antimicrobials was tested against 74 recent anaerobic isolates obtained from pretreatment cultures in pediatric patients with complicated intra-abdominal infections using the CLSI M11-A-6 agar dilution method. Carbapenems, beta-lactamase inhibitor combinations and metronidazole retained good activity, while all Bacteroides fragilis group species produced beta-lactamase and were penicillin resistant and 43% were either intermediately susceptible or resistant to clindamycin. Cefoxitin had moderate activity against B. fragilis but poor activity against Bacteroides thetaiotaomicron and other B. fragilis group isolates.
Goldstein
Ellie J C
EJ
R.M. Alden Research Laboratory, 2021 Santa Monica Blvd, # 740E, Santa Monica, CA 90404, USA. ejcgmd@aol.com
Citron
Diane M
DM
Vaidya
Sagar A
SA
Warren
Yumi A
YA
Tyrrell
Kerin L
KL
Vreni Merriam
C
C
Fernandez
Helen
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents