title: Haematopoietic stem cell transplantation as primary therapy of sporadic adult Burkitt lymphoma.
abstract: High dose chemoradiotherapy and haematopoietic stem cell transplantation (SCT) is used as primary therapy for patients diagnosed with Burkitt lymphoma (BL). Forty-three adults presented with sporadic BL in British Columbia between 1987 and 2003. Twenty patients had bone marrow involvement. Sixteen patients did not proceed to SCT because of chemorefractory disease (n = 9) or other reasons (n = 7). Twenty-seven patients proceeded to SCT and had a 3-year event-free survival of 51%. In conclusion, approximately 50% of patients with chemosensitive BL who undergo SCT can be cured; however, a significant number of patients will not proceed to SCT because of early resistance or recurrence.
authors.affiliation: Division of Hematology, Leukemia/Bone Marrow Transplant Program of British Columbia, the Vancouver Hospital and Heath Science Centre, Vancouver, BC, Canada. ksong@bccancer.bc.ca
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Song
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Barnett
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Horsman
authors.forename: Donna L
authors.initials: DL
authors.lastname: Forrest
authors.forename: Donna E
authors.initials: DE
authors.lastname: Hogge
authors.forename: Julyle C
authors.initials: JC
authors.lastname: Lavoie
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Nantel
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Nevill
authors.forename: John D
authors.initials: JD
authors.lastname: Shepherd
authors.forename: Clayton A
authors.initials: CA
authors.lastname: Smith
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Sutherland
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Voss
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Toze
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Connors
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome