title: [Therapeutic effects of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers].
abstract: OBJECTIVE
  To explore the therapeutic effects and mechanisms of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers.
  
  
  METHODS
  One hundred and twenty patients were randomly divided into 6 groups. Another 10 patients as the control group were confirmed with no peptic ulcers by endoscope, but had digestive tract symptoms. The clinical effects were compared among each group after the one month treatment.
  
  
  RESULTS
  The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome (P < 0.01 to 0.05), but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules (P > 0.05). The combination of Jianweiyuyang granules and ranitidine capsules could significantly upregulate the expression of MUCSAC mRNA (P < 0.01), while downregulate the expression of ETAR mRNA (P < 0.01).
  
  
  CONCLUSIONS
  There is obvious advantage in treating peptic ulcers by the combination of Jianweiyuyang granules and ranitidine capsules, and its mechanisms may be to protect the gastric mucosal barrier by up-regulating the expression of MUCSAC mRNA and to improve the gastric mucosal blood flow by down-regulating the expression of ETAR mRNA.
authors.affiliation: Affiliated Hospital of Traditional Chinese Medicine of Hunan Province, Changsha 410006, Changsha 410008, China. zhoubingbing@126.com
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Jia-bang
authors.initials: JB
authors.lastname: Li
authors.forename: Guang-xian
authors.initials: GX
authors.lastname: Cai
authors.forename: Jiang-hong
authors.initials: JH
authors.lastname: Ling
authors.forename: Xing-ping
authors.initials: XP
authors.lastname: Dai
mesh_terms: D000328:Adult; D002214:Capsules; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D019332:Endothelin-1 / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000096:biosynthesis / Q000235:genetics; D010437:Peptic Ulcer / Q000188:drug therapy*; D008517:Phytotherapy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011899:Ranitidine / Q000627:therapeutic use*; D017466:Receptors, Endothelin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins; D012333:RNA, Messenger; D017466:Receptors, Endothelin; D011899:Ranitidine