Stereoselective construction of cis-2,6-disubstituted tetrahydropyrans via an intramolecular bismuth-mediated oxa-conjugate addition reaction.
The intramolecular oxa-conjugate addition of tethered triethylsilyloxy substituted alpha,beta-unsaturated ketones mediated by bismuth(III) nitrate pentahydrate provides a mild and efficient method for the stereoselective construction of cis-2,6-disubstituted tetrahydropyrans.
Evans
P Andrew
PA
Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Andrews
William J
WJ