[Research on association between atherosclerotic brain infarction and human leukocyte antigen DR gene].
OBJECTIVE
To evaluate the relationship between atherosclerotic brain infarction (ABI) and human leukocyte antigen DR (HLA-DR) gene at molecular level.


METHODS
By using polymerase chain reaction sequence specific probe (PCR-SSP), gene special position of the HLA-II DR alleles were determined in 31 patients and 30 healthy individuals as controls, all of them were inhabitants of Northeastern China.


RESULTS
The HLA-DR B1*0301 gene frequency in the group of ABI was obviously higher than that of control group (RR=5.6842, P<0.05).


CONCLUSIONS
The HLA-DR B1*0301 gene may be the susceptible gene of ABI in Northeastern China, or it may associate with other genes to produce the disease.
Zhang
Shuang-yan
SY
Harbin The First Hospital, Harbin 150010, Heilongjiang, China.
Wu
Ying-quan
YQ
Yu
Ming
M
Cao
Feng-lin
FL
Zhang
Xian-zhong
XZ
D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens