PSORS1: linking genetics and immunology.
Previous studies have localized the psoriasis susceptibility 1 (PSORS1) locus to the proximal major histocompatibility complex class I region, but approximately a dozen genes in the candidate region have thus far been genetically inseparable. According to a team of researchers in the United States and Germany, the primary genetic association has now been worked out, implicating HLA-Cw6 "after all." The results integrate genetics and immunology, further reinforcing our emerging understanding of psoriasis.
Elder
James T
JT
University of Michigan Medical Center, Department of Dermatology, Ann Arbor, Michigan, USA. jelder@umich.edu
D008040:Genetic Linkage; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007109:Immunity / Q000235:genetics; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*
D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; C484393:PSORS1C1 protein, human; D011506:Proteins