[Anesthetic protection against hepatic injury].
In this review article, hepatocyte injury by volatile anesthetics, effects of anesthetics on hepatic perfusion, protection offered by either ischemic preconditioning or anesthetic preconditioning against hepatic ischemia-reperfusion injury and effects of anesthetics on sepsis-induced hepatic injury are discussed. Halothane poses significant risk of immunologically-mediated hepatocyte injury and disturbances of hepatic blood supply. Other modern volatile anesthetics such as isoflurane, sevoflurane and desflurane seem to have only minor risks. Several animal studies demonstrate that volatile anesthetics offer more protection against ischemia-reperfusion injury than intravenous anesthetics. On the contrary, intravenous anesthetics may be more protective against sepsis-induced hepatic injury than volatile anesthetics.
Kotake
Yoshifumi
Y
Department of Anesthesiology, School of Medicine, Keio University, Tokyo 160-8582.
D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning; D008099:Liver / Q000187:drug effects*; D008102:Liver Circulation / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control
D000777:Anesthetics; D018686:Anesthetics, Intravenous; D020011:Protective Agents