Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects.
Itopride hydrochloride (itopride), a gastrokinetic drug, has recently been evaluated for its clinical usefulness in functional dyspepsia. We investigated effects of itopride on human plasma gastrin-, somatostatin-, motilin-, and cholecystokinin (CCK)-like immunoreactive substances (IS); adrenocorticotropic hormone (ACTH)-immunoreactive substances (IS), and cortisol under stress conditions in healthy subjects. A single administration of itopride caused significant increases in plasma somatostatin- and motilin-IS levels compared to placebo. Itopride significantly decreased plasma CCK-IS, and suppressed the ACTH-IS level compared to placebo. We hypothesize that itopride may have an accelerating gastric emptying effect, and a modulatory effect on the hypothalamo-pituitary-adrenal axis and autonomic nervous functions. These effects might be beneficial in stress-related diseases, suggesting that itopride has clinicopharmacological activities.
Katagiri
Fumihiko
F
Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita, Japan. FKATA@med.oita-u.ac.jp
Shiga
Toru
T
Inoue
Shin
S
Sato
Yuhki
Y
Itoh
Hiroki
H
Takeyama
Masaharu
M
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001549:Benzamides / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002766:Cholecystokinin / Q000097:blood*; D005755:Gastrins / Q000097:blood; D005765:Gastrointestinal Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009037:Motilin / Q000097:blood*; D013004:Somatostatin / Q000097:blood*
D001549:Benzamides; D001593:Benzyl Compounds; D005755:Gastrins; D005765:Gastrointestinal Agents; D013004:Somatostatin; D009037:Motilin; C102254:itopride; D000324:Adrenocorticotropic Hormone; D002766:Cholecystokinin; D006854:Hydrocortisone