Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians.
We have previously shown that antibody titres to several heat-shock proteins (Hsps) are elevated in dyslipidaemic patients and subjects with established vascular disease. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. Hence, we have investigated the association between indices of obesity and several Hsp antibody titres in healthy subjects. Subjects (n=170) were recruited from among employees at the University of Surrey and the Royal Surrey County Hospital, Guildford, UK. Of these subjects, 35 were obese with a body mass index (BMI)>/=30 kg/m(2) (19 male and 16 female subjects), 58 were overweight with 30>BMI>/=25 kg/m(2) (36 male and 22 female subjects) and 77 were of a normal weight with BMI<25 kg/m(2) (31 male and 46 female subjects). Overall, obese subjects had significantly higher plasma anti-Hsp-60 (P<0.001), anti-Hsp-65 (P<0.05) and anti-Hsp-70 (P<0.05) compared with overweight and normal weight subjects.
Ghayour-Mobarhan
M
M
Centre for Clinical Science & Measurement, School of Biomedical & Molecular Science, University of Surrey, Guildford, Surrey, UK.
Taylor
A
A
Lamb
D J
DJ
Ferns
G A A
GA
D000906:Antibodies / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000276:immunology; D015992:Body Mass Index; D049628:Body Size / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D018834:Chaperonin 60 / Q000276:immunology; D002784:Cholesterol / Q000097:blood; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000276:immunology*; D014280:Triglycerides / Q000097:blood; D024101:Mitochondrial Proteins
D000906:Antibodies; D001786:Blood Glucose; D002097:C-Reactive Protein; D018834:Chaperonin 60; D002784:Cholesterol; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D014280:Triglycerides; C060293:HSPD1 protein, human; D024101:Mitochondrial Proteins