title: Effectiveness of linezolid and imipenem association in the treatment of severe community-acquired pneumonia in children: two case reports.
abstract: Two children with severe pneumonia, purulent pleural effusions, and abscess formation unresponsive to appropriate antibiotic therapy recovered promptly after the introduction of linezolid and imipenem association. Linezolid is a new antibiotic with high bioavailability and an outstanding safety profile, synergistic with imipenem, which may deserve a place in the armamentarium for severe pneumonia in children.
authors.affiliation: Réanimation Pédiatrique, Hôpital Mère Enfant, CHU-Nantes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Godon
authors.forename: Sophie
authors.initials: S
authors.lastname: Denizot
authors.forename: Guillaume
authors.initials: G
authors.lastname: Podevin
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Caillon
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
authors.forename: Jean
authors.initials: J
authors.lastname: Christophe Roze
authors.forename: Christele
authors.initials: C
authors.lastname: Gras-Le Guen
mesh_terms: D000081:Acetamides / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015378:Imipenem / Q000009:adverse effects / Q000627:therapeutic use*; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000009:adverse effects / Q000627:therapeutic use*; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012449:Safety; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D015378:Imipenem; D000069349:Linezolid