Survivin regulation of vascular injury.
Survivin is a protein member of the inhibitor of apoptosis family that has attracted attention for its dual essential roles in the regulation of cell division and the control of apoptosis. Although extensively characterized as a tumor gene and exploited for new opportunities in cancer diagnostics and therapeutics, fresh experimental evidence has uncovered a critical role of survivin in vascular cell responses in vivo. Dynamically embedded in broad signaling pathways controlling smooth muscle cell adaptation, survivin not only controls vascular wall homeostasis but also acts as a critical upstream regulator of gene expression and second mediators.
Conte
Michael S
MS
Department of Vascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Altieri
Dario C
DC
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D002455:Cell Division; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D000077022:Survivin; D014652:Vascular Diseases / Q000378:metabolism* / Q000473:pathology
C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin