title: NR3 protein expression in trigeminal neurons during postnatal development.
abstract: The N-methyl-d-aspartate (NMDA) receptor plays an important role in the generation of rhythmical oral motor activities. To compliment our previous studies, we examined the developmental regulation of NR3A and NR3B expression in trigeminal motoneurons (Mo5) and mesencephalic trigeminal neurons (Me5). NR3A-immunoreactive neurons were observed at all ages in both nuclei, decreasing in Mo5 and caudal Me5 after P14, and increasing in rostral Me5. NR3B protein expression only emerged in Mo5 after P21-23. Results indicate that NR3A and NR3B expression is differentially regulated between Mo5 and Me5 coincident with the transition from suckling to chewing.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihama
authors.forename: Jack E
authors.initials: JE
authors.lastname: Turman
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007150:Immunohistochemistry / Q000379:methods; D008636:Mesencephalon / Q000166:cytology* / Q000254:growth & development; D009046:Motor Neurons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D014278:Trigeminal Nuclei / Q000166:cytology* / Q000254:growth & development
chemical_list: C464437:NR3A NMDA receptor; C501155:NR3B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate