Paget sarcoma of the spine: Scottish Bone Tumor Registry experience.
METHODS
Retrospective case study of 13 cases of Paget sarcoma of the spine accrued from a prospectively collected Tumor Registry database.


OBJECTIVE
To analyze the clinical, radiologic, and histologic features of Paget sarcoma of the spine and to determine the factors influencing the prognosis.


BACKGROUND
Paget disease of bone is a common disorder with the spine being involved in over 50% of patients. However, sarcomatous degeneration in the vertebral column is an extremely rare complication. There is very little in the literature with regard to clinical presentation and prognosis of patients with Paget sarcoma affecting the vertebral column.


METHODS
Between January 1944 and December 2003, 89 patients were registered with a diagnosis of Paget sarcoma in the Scottish Bone Tumor Registry. Thirteen patients with Paget sarcoma of the spine were analyzed with regard to their clinical, radiologic, and histopathologic features along with the prognostic predictors.


RESULTS
The mean age was 66.9 years (range: 56-79 years). There were 10 males and three females. There were seven cases involving the sacral spine (63.6%), three cases involving lumbar vertebrae, two affecting the dorsal spine, and one with diffuse dorsolumbar involvement (D11-L3). The mode of presentation was progressively increasing low back pain (in all 13), unilateral sciatica (six; left-sided, five; right-sided, one), bilateral sciatica (two), lower limb weakness (eight), and autonomic dysfunction (four). Ten of 13 cases (76.9%) were osteosarcoma. The rest were chondrosarcoma (n = 1), fibrosarcoma (n = 1), and malignant fibrous histiocytoma (n = 1). Decompression laminectomy was performed in three patients with progressive neurologic deficit. Eight patients had received radiotherapy. The mean survival was 4.22 months.


CONCLUSIONS
This series confirmed that Paget sarcoma of the spine has a very poor prognosis. We found a constellation of symptomatology in patients with sarcomatous Paget spine resulting from radiculomedullary compression, primarily lumbosacral involvement and predominantly osteosarcomatous histology. There was no significant difference observed on the overall prognosis of the patients with Paget sarcoma of the spine in the last 6 decades.
Department of Orthopaedic Surgery, Scottish Bone Tumor Registry, Western Infirmary, Glasgow, UK. hksharma1@aol.com
Sharma
Himanshu
H
Mehdi
S A
SA
MacDuff
E
E
Reece
A T
AT
Jane
M J
MJ
Reid
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000150:complications / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D010001:Osteitis Deformans / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D012042:Registries; D012189:Retrospective Studies; D012447:Sacrum; D012509:Sarcoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D013117:Spinal Cord Compression / Q000150:complications / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D013126:Spinal Nerve Roots; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed