Signaling from across the way: transactivation of VEGF receptors by HSPGs.
Heparan sulfate proteoglycans (HSPGs) influence the signaling of many growth factors, and recent work shows that they can promote VEGF signaling in trans from the surface of an adjacent cell. This mode of signaling also alters the activation state and internalization of VEGF receptors.
Selleck
Scott B
SB
Department of Pediatrics, The Development Biology Center, The University of Minnesota, Minneapolis, 55455, USA.
D000581:Amidohydrolases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D051379:Mice; D018919:Neovascularization, Physiologic; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction; D015238:Sulfotransferases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism
D019812:Heparan Sulfate Proteoglycans; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D040262:Receptors, Vascular Endothelial Growth Factor; D040301:Vascular Endothelial Growth Factor Receptor-2; C491855:Ndst2 protein, mouse; D015238:Sulfotransferases; C021350:heparitin sulfotransferase; D000581:Amidohydrolases