[Kinetic features of a white rat hepatocyte population under hormonal disbalance before and after partial hepatectomy].
Bilateral adrenalectomy, followed in 4 days by a partial hepatectomy, was performed using white rats weighing as much as 120-140 g. Under hormonal disbalance caused by bilateral adrenalectomy, the number of polyploid (4c, 4c x 2, and 8c) hepatocytes significantly increased, compared to that in non-operated control rats. Six hours after a partial hepatectomy, the share of highly ploid hepatocytes falls, being accompanied by a 9-fold increase in mitotic index. It is supposed that under hormonal disbalance condition, a partial hepatectomy may induce "early" mitoses in hepatocytes blocked in G2-phase of the cell cycle.
Dzidziguri
D V
DV
Kudriavtsev
B N
BN
Modebadze
I R
IR
Arkad'eva
A V
AV
Bakuradze
E D
ED
D000311:Adrenal Glands / Q000503:physiopathology* / Q000601:surgery; D000315:Adrenalectomy / Q000009:adverse effects; D000818:Animals; D004195:Disease Models, Animal; D016195:G2 Phase / Q000502:physiology; D006498:Hepatectomy; D022781:Hepatocytes / Q000473:pathology*; D008099:Liver / Q000503:physiopathology* / Q000601:surgery; D008115:Liver Regeneration; D008940:Mitotic Index; D011123:Polyploidy; D051381:Rats