Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.
The aqueous suspension of Withania somnifera root powder was investigated for their in vivo and in vitro immunomodulatory properties. W. somnifera showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction. Administration of W. somnifera root powder did not have a significant effect on humoral immune response in rats. Our results report immunosuppressive effect of W. somnifera root powder, thus it could be a candidate for developing as an immunosuppressive drug for the inflammatory diseases.
Rasool
M
M
Department of Biosciences, Vellore Institute of Technology, Deemed University, Vellore-632 014, India. mkr474@rediffmail.com
Varalakshmi
P
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology; D049109:Cell Proliferation; D002478:Cells, Cultured; D003167:Complement Activation / Q000187:drug effects; D051056:Complement Inactivating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000276:immunology; D005620:Freund's Adjuvant / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D032341:Withania
D000893:Anti-Inflammatory Agents; D051056:Complement Inactivating Agents; D010936:Plant Extracts; D005620:Freund's Adjuvant