title: Surgical treatment of differentiated thyroid carcinoma: a retrospective study.
abstract: A retrospective study was carried out to assessed reliability of the prognostic factors (histology, age, sex, and stage), and standard procedures for the surgical treatment of differentiated thyroid cancers (DTC). From the 144 DTC cases reviewed with follow-up ranging from 1 to 25 years (m = 6.33 years), total mortality for cancer was found to be 55% (8 patients), with a predictive positive value for recurrence of 95.4% and 91.8% at 12 and 24 months, respectively. Median survival was 8.8 years (range 1 to 25 years). The multivariate analysis showed that factors such as age > 45 years, histology of intermediate malignancy, size up to 1.5 cm, and presence of metastases, significantly worsened the prognosis, regardless of the intervention that was carried out. We suggest total thyroidectomy for the treatment of benign pathologies and confirmed or suspected cases of cancer. We reserve loboisthmectomy for the treatment of benign pathologies confined to one lobe or those with FNAB suggesting a follicular neoplasm.
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy. pasquale.sperlongano@unina2.it
authors.forename: Pasquale
authors.initials: P
authors.lastname: Sperlongano
authors.forename: Domenico
authors.initials: D
authors.lastname: Parmeggiani
authors.forename: Donatella
authors.initials: D
authors.lastname: Pisaniello
authors.forename: Massimo
authors.initials: M
authors.lastname: De Falco
authors.forename: Ignazio
authors.initials: I
authors.lastname: Sordelli
authors.forename: Marina
authors.initials: M
authors.lastname: Accardo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cuccurullo
authors.forename: Luigi
authors.initials: L
authors.lastname: Mansi
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tartaro
authors.forename: Alfonso
authors.initials: A
authors.lastname: Barbarisi
authors.forename: Nicola
authors.initials: N
authors.lastname: Avenia
authors.forename: Umberto
authors.initials: U
authors.lastname: Parmeggiani
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome