title: [Plasmid elimination effect of usnic acid on antibiotic-resistant Staphylococcus aureus].
abstract: OBJECTIVE
  To observe the influence of Usnic acid on the antibiotic-resistant plasmid in Staphylococcus aureus (Sa).
  
  
  METHODS
  The antibiotic-resistant plasmid was abstracted from the clinical divided strain of Sa and plasmid elimination test was performed in vitro.
  
  
  RESULTS
  Plasmid elimination test showed that Usnic acid could eliminate the resistant plasmid in Sa effectively. At 24th and 48th hour after the treatment of Usnic acid, the elimination rate of resistant plasmid was 5.2% and 16.4% respectively.
  
  
  CONCLUSIONS
  Usnic acid can eliminate the antibiotic-resistant plasmid in Sa. It is possible to use Usnic acid to treat the infection of antibiotic-resistant Sa in clinic.
authors.affiliation: College of Stomatology, Tongji University, Shanghai 200072, China. wxp990@hotmail.com
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
authors.forename: Hai-Jiang
authors.initials: HJ
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhen
authors.forename: Zeng-Tong
authors.initials: ZT
authors.lastname: Zhou
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Li
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004587:Electrophoresis, Agar Gel; D011815:R Factors / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; C073339:usnic acid