Frontotemporal dementia.
Frontotemporal dementia is a clinicopathological syndrome caused by progressive degeneration of the frontal lobes, anterior temporal lobes or both. A wide spectrum of cognitive, psychological and behavioural symptoms has been reported, with early disturbance of personality and social conduct, impairment of executive functions and language, while memory and visuo-spatial skills are usually preserved. Published criteria can lead to a good accuracy in the antemortem diagnosis of frontotemporal dementia with a sensitivity of 85% and a specificity of 99%. Treatment rests on the management of behavioural disturbances.
Mariani
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C
Cattedra di Neurologia, Università degli Studi di Milano, Milan, Italy. claudio.mariani@unimi.it
Defendi
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S
Mailland
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E
Pomati
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S
D003704:Dementia / Q000150:complications / Q000473:pathology / Q000523:psychology; D006801:Humans