[Study on the function of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbit blood stasis model].
OBJECTIVE
To evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis and pathology on rabbit blood stasis model.


METHODS
Thirty rabbits were ramdomly divided into normal group, model group, high dose group, low dose group and Xue Shuan Ning group. Tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One rot was solected randomly from each group to observe pathological changes.


RESULTS
There were significant differences in t-PA, PAI, Fbg and DD between normal group and other groups is very obvious (P < 0.01) . Between groups of high dose low dose Xue Shuan Ning and model, the statistical differeces were significant, as well as between groups of high dose, low dose and Xue Shuan Ning groups (P < 0.05). However, there was no statistical difference between high dose group and high dose group (P > 0.05). The pathological changes in model group were most serious, those in Xue Shuan Ning were less serious. There were slight pathological changes in high dose group and low dose group.


CONCLUSIONS
Models ware made successfully. High dose group and low dose group have stronger effect on thrombosis than Xue Shuan Ning group.
Zhan
Xiao-ping
XP
The Second Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Sun
Mei
M
Jin
Xiao-ying
XY
Jin
Chen-yu
CY
Xu
Xi-hong
XH
Qin
Guang-ming
GM
Bao
Juan
J
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D015849:Plasminogen Inactivators / Q000097:blood; D011817:Rabbits; D011897:Random Allocation; D013927:Thrombosis / Q000097:blood* / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000097:blood*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; D015849:Plasminogen Inactivators; C036309:fibrin fragment D; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator