title: ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.
abstract: ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression.
authors.affiliation: Ludwig Institute for Cancer Research, University College London, London W1W 7BS, United Kingdom.
authors.forename: Virginie
authors.initials: V
authors.lastname: Vives
authors.forename: Jian
authors.initials: J
authors.lastname: Su
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.forename: Indrika
authors.initials: I
authors.lastname: Ratnayaka
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Slee
authors.forename: Robert
authors.initials: R
authors.lastname: Goldin
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
mesh_terms: D000483:Alleles; D000818:Animals; D005804:Genes, Lethal; D016147:Genes, Tumor Suppressor; D006238:Haploidy; D006579:Heterozygote; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C511437:Trp53bp2 protein, mouse; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins