The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms.
The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.
Schölz
Christian
C
Institute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University Frankfurt, Marie-Curie-Str. 9, D-60439, Frankfurt a.M., Germany.
Tampé
Robert
R
D018528:ATP-Binding Cassette Transporters; D017951:Antigen Presentation; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007157:Immunologic Surveillance; D014780:Viruses / Q000276:immunology
D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; C477327:transporter associated with antigen processing (TAP)