Myocardial infarction caused by Aspergillus embolization in a patient with aplastic anemia.
A 38-year-old Japanese man with severe aplastic anemia had invasive pulmonary aspergillosis as a complication. He was treated with amphotericin B for six weeks, but the aspergillosis did not improve. Then he experienced a fatal myocardial infarction. An autopsy revealed disseminated aspergillosis involving pericarditis and Aspergillus embolization to the coronary arteries. This led to the acute myocardial infarction. Cardiac aspergillosis is rare, but should be included within the differential diagnosis when chest pain of unknown origin occurs in an immunosuppressed patient.
Itoh
Mitsuru
M
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Matsushima, Kurashiki.
Takahashi
Masahiko
M
Mori
Miyuki
M
Tamekiyo
Hiromichi
H
Yoshida
Hiroshi
H
Yago
Kazuhiro
K
Shimada
Hideto
H
Arai
Kazumori
K
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D003327:Coronary Disease / Q000209:etiology; D004617:Embolism / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology*; D010493:Pericarditis / Q000150:complications
D000935:Antifungal Agents; D000666:Amphotericin B