Demyelinating polyneuropathy in Leber hereditary optic neuropathy.
We report a patient with Leber hereditary optic neuropathy (G11778A mtDNA) and a severe demyelinating neuropathy, for which no other cause except his mitochondrial disorder could be found. The involvement of the peripheral nervous system of patients with LHON, in particular with a 11778 mtDNA, is discussed.
Gilhuis
H J
HJ
Department of Neurology and Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. gilhuis@rdgg.nl
Schelhaas
H J
HJ
Cruysberg
J R M
JR
Zwarts
M J
MJ
D004272:DNA, Mitochondrial / Q000235:genetics; D003711:Demyelinating Diseases / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D029242:Optic Atrophy, Hereditary, Leber / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D011115:Polyneuropathies / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000473:pathology
D004272:DNA, Mitochondrial