Magnetic resonance imaging changes in Fabry disease.
Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non-specific white and grey matter lesions, vascular anomalies, in particular dolicho-ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age.


CONCLUSIONS
MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.
Ginsberg
Lionel
L
Department of Neurology, Royal Free Hospital, London, UK. Lionel.Ginsberg@royalfree.nhs.uk
Manara
Renzo
R
Valentine
Alan R
AR
Kendall
Brian
B
Burlina
Alessandro P
AP
D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology; D000795:Fabry Disease / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging