title: Pulmonary function and sleep-related breathing disorders in severely obese children.
abstract: OBJECTIVE
  To evaluate the frequency of pulmonary function and sleep-breathing disorders in severely obese children and to search for their association with obesity phenotypes.
  
  
  METHODS
  Sleep studies and spirometry were performed for 54 severely obese children.
  
  
  RESULTS
  Upper airway resistances (RAWs) were increased with RAW>200% and forced 25s expiratory volume<80% in 83% and 60% of individuals, respectively. A decrease in functional residual capacity (FRC)<80% was found in 43%. Fifty-two percent of the children had a desaturation index>10 during sleep, and 41% of children presented at least one of three severity criteria (snoring index>300 per hour, respiratory events index (REI)>10 and arousal index>10). Univariate analyses showed a positive correlation between snoring index and BMI Z-score and neck/height ratio (P=0.01 and 0.04, respectively) as between REI and the same parameters (P=0.01 and 0.03, respectively). In a multivariate model with BMI Z-score, NHR still correlated with the snoring index (P=0.02) and REI (P=0.01).
  
  
  CONCLUSIONS
  In our cohort, obese children showed frequent pulmonary function and sleep-breathing disorders. The later were associated with impaired upper airway respiratory conductance.
authors.affiliation: Armand-Trousseau Teaching Hospital, Department of Pediatric Gastroenterology and Nutrition, Avenue du Dr Arnold Netter, Paris, France.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Dubern
authors.forename: Patrick
authors.initials: P
authors.lastname: Tounian
authors.forename: Noria
authors.initials: N
authors.lastname: Medjadhi
authors.forename: Lucia
authors.initials: L
authors.lastname: Maingot
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Girardet
authors.forename: Michéle
authors.initials: M
authors.lastname: Boulé
mesh_terms: D000704:Analysis of Variance; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D009767:Obesity, Morbid / Q000150:complications* / Q000503:physiopathology; D010641:Phenotype; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D012913:Snoring; D013147:Spirometry; D014797:Vital Capacity