title: Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times.
abstract: The aim of the study is to investigate whether platelet activity is increased by hyperprolactinemia during pregnancy as reflected by beta-thromboglobulin level. Forty-eight healthy, pregnant, and 30 healthy, non-pregnant women were investigated with respect to platelet count, collagen/ADP and collagen/epinephrine closure times, beta-thromboglobulin and prolactin levels. The comparison of the variables between the two groups was made by Mann-Whitney U test. The correlation analyses were performed by Spearman's rank correlation test. Our results revealed that platelet counts, collagen/ADP and collagen/epinephrine closure times and beta-thromboglobulin showed no statistically significant differences between pregnant and non-pregnant women. We found no significant correlation between prolactin and collagen/ADP closure time (r = 0.175), between prolactin and collagen/epinephrine closure time (r = -0.112) and between prolactin and beta-thromboglobulin (r = 0.220) in pregnant women. Our findings suggest that platelet activity is comparable during pregnant and non-pregnant states and there is no significant effect of prolactin on platelet function in vivo as reflected by beta-thromboglobulin level.
authors.affiliation: Hacettepe University School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ankara, Turkey. aysegulakin@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Atmaca
authors.forename: A
authors.initials: A
authors.lastname: Gurlek
authors.forename: S
authors.initials: S
authors.lastname: Dagdelen
authors.forename: N
authors.initials: N
authors.lastname: Erarslan
authors.forename: Y
authors.initials: Y
authors.lastname: Buyukasik
authors.forename: M
authors.initials: M
authors.lastname: Gultekin
authors.forename: B S
authors.initials: BS
authors.lastname: Karamursel
authors.forename: L
authors.initials: L
authors.lastname: Onderoglu
mesh_terms: D000244:Adenosine Diphosphate / Q000737:chemistry; D000328:Adult; D001760:Bleeding Time; D003094:Collagen / Q000737:chemistry; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D010973:Platelet Adhesiveness; D010976:Platelet Count; D010979:Platelet Function Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011388:Prolactin / Q000097:blood*
chemical_list: D000244:Adenosine Diphosphate; D011388:Prolactin; D003094:Collagen