Epistatic kinship a new measure of genetic diversity for short-term phylogenetic structures--theoretical investigations.
The epistatic kinship describes the probability that chromosomal segments of length x in Morgan are identical by descent. It is an extension from the single locus consideration of the kinship coefficient to chromosomal segments. The parameter reflects the number of meioses separating individuals or populations. Hence it is suggested as a measure to quantify the genetic distance of subpopulations that have been separated only few generations ago. Algorithms for the epistatic kinship and the extension of the rules to set up the rectangular relationship matrix are presented. The properties of the epistatic kinship based on pedigree information were investigated theoretically. Pedigree data are often missing for small livestock populations. Therefore, an approach to estimate epistatic kinship based on molecular marker data are suggested. For the epistatic kinship based on marker information haplotypes are relevant. An easy and fast method that derives haplotypes and the respective frequencies without pedigree information was derived based on sampled full-sib pairs. Different parameters of the sampling scheme were tested in a simulation study. The power of the method decreases with increasing segment length and with increasing number of segments genotyped. Further, it is shown that the efficiency of the approach is influenced by the number of animals genotyped and the polymorphism of the markers. It is discussed that the suggested method has a considerable potential to allow a phylogenetic differentiation between close populations, where small sample size can be balanced by the number, the length, and the degree of polymorphism of the chromosome segments considered.
Flury
C
C
Institute of Animal Breeding and Genetics, Georg-August-University of Göttingen, Gottingen, Germany. cflury@gwdg.de
Tietze
M
M
Simianer
H
H
D000465:Algorithms; D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics*; D003198:Computer Simulation; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D007178:Inbreeding; D008957:Models, Genetic; D010375:Pedigree; D010802:Phylogeny
D005819:Genetic Markers