Styrenic block copolymers for biomaterial and drug delivery applications.
The use of styrenic block copolymers has undergone a renaissance as a biomaterial and drug delivery matrix. The early promise posed by the physical and biological properties of these block copolymers for implantable medical devices was not met. However, there has been an increased understanding of the role of microphase separation on the mediation of the biological response. Poly (styrene-b-isobutylene-b-styrene) (SIBS) block copolymer has critical enabling properties related to processing, vascular compatibility and bio-stability that has resulted in its use as the matrix for paclitaxel delivery from Boston Scientific's TAXUS coronary stent. These enabling properties will allow the continuing development of medical devices based on SIBS that meet demanding physical and biological requirements.
Ranade
Shrirang V
SV
Corporate Research and Advanced Technology Development, Boston Scientific Corporation, 1 Boston Scientific Place, Natick, MA 01760, USA. ranades@bsci.com
Richard
Robert E
RE
Helmus
Michael N
MN
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D003331:Coronary Vessels / Q000601:surgery; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008854:Microscopy, Electron; D017239:Paclitaxel / Q000008:administration & dosage; D011137:Polystyrenes / Q000737:chemistry*; D015607:Stents; D013552:Swine
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011137:Polystyrenes; C024075:styrofoam; D017239:Paclitaxel