Urine glycosyl albumin formation: relation to severe nephropathy in the poor control diabetes mellitus patients?
Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Urine glycosyl albumin is an important finding in the patients with severe diabetic nephropathy. In addition, accumulation of glycated albumin in end-stage renal failure is noted. Here, the author performed a reappraisal on the bonding energy based on quantum chemical analysis. The author calculated the bonding energy of the reaction and found that the reaction is a type of "energy providing reaction." The author hereby proposed that the nature of energy providing reaction in formation of glycosyl albumin can be an insult to the surrounding renal tissues in poorly controlled DM patients. Giving out the energy from the nearby cellular compartment during formation of glycosyl albumin might be an important pathological process leading to severe diabetic nephropathy and renal failure.
Wiwanitkit
Viroj
V
D000419:Albuminuria / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000628:therapy / Q000652:urine*; D004734:Energy Metabolism; D006031:Glycosylation; D006801:Humans; D012720:Severity of Illness Index