title: Asymmetric synthesis of polyfunctionalized pyrrolidines from sulfinimine-derived pyrrolidine 2-phosphonates. Synthesis of pyrrolidine 225C.
abstract: [reaction: see text] The Horner-Wadsworth-Emmons reaction of aldehydes with sulfinimine-derived 3-oxo pyrrolidine phosphonates represents a new method for the asymmetric synthesis of ring-functionalized cis-2,5-disubstituted 3-oxo pyrrolidines.
authors.affiliation: Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@temple.edu
authors.forename: Franklin A
authors.initials: FA
authors.lastname: Davis
authors.forename: He
authors.initials: H
authors.lastname: Xu
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Wu
authors.forename: Junyi
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007097:Imines; D063065:Organophosphonates; D011759:Pyrrolidines; C518113:pyrrolidine 225C