[Effects of Yifuning capsule on blood lipids of ovariectomized hyperlipidemia rats].
OBJECTIVE
To observe the effects of Yifuning (YEN) capsule on blood lipids of ovariectomized hyperlipidemia rats.


METHODS
Fifty-six female mature Sprague-Dawley rats were randomized into 7 groups: normal control group, model control group, diethylstilbestrol tablets (DT) group, Xuezhikang group, YFN high, middle and low dose groups. The ovariectomized rats were fed on high fat diet and administrated with the drugs for 3 weeks, then were killed and estimated body weight, liver index and five items of blood lipid (TC, TG, HDL-C, LDL-C, VLDL) by test kit. Enzyme (such as HP, LDL, and whole lipase) was detected too.


RESULTS
The weight and liver index of model control group increased obviously as compared with normal group. YFN could reduce TG, TC, and LDL-C (P < 0.05) of ovariectomized hyperlipidemia rats obviously and increase HP, LDL and whole lipase (P < 0.05) on the other hand.


CONCLUSIONS
YFN can ameliorate blood lipids of ovariectomized hyperlipidemia rats.
Wang
Zhi-xia
ZX
College of Traditional Chinese Medicine and Pharmacy, Southern Medical University, Guangzhou, China.
Deng
Hong-zhu
HZ
Chen
Jian-guo
JG
Liu
Pei-zhong
PZ
D000818:Animals; D002214:Capsules; D030024:Curcuma / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006949:Hyperlipidemias / Q000097:blood*; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D010052:Ovariectomy; D010057:Oviducts / Q000737:chemistry; D011897:Random Allocation; D011898:Ranidae; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008055:Lipids; D008419:Materia Medica; D008049:Lipase; C502353:hepatic lipase, rat; D008071:Lipoprotein Lipase