title: The effect of desflurane and sevoflurane on cerebral oximetry under steady-state conditions.
abstract: We studied the effect of sevoflurane and desflurane on regional cerebral oxygenation (rSO2). Twenty-two patients undergoing abdominal hysterectomy received sevoflurane and desflurane for 15 min each and 30 min apart under steady-state conditions in a randomized, crossover manner to maintain a bispectral index (BIS) of 40-50. In another 22 patients undergoing the same anesthesia and surgery BIS was maintained at 20-30. During the 15-min administration of each anesthetic at steady-state conditions rSO2, BIS, inspired and end-tidal anesthetic concentrations, end-tidal CO2, Spo2, systolic and diastolic blood pressures, and heart rate were recorded every 3 min. The rSO2 did not differ between sevoflurane and desflurane when BIS values were maintained between 40-50 or 20-30. The MAC(BIS) values required to maintain BIS at 40-50 and at 20-30 were 1.0 versus 1.2 (P = 0.004) and 1.6 versus 1.8 (P < 0.001) for desflurane and sevoflurane respectively. Higher rSO2 values were obtained by 1.6 MAC (71 +/- 13) than by 1 MAC of desflurane (66 +/- 10; P < 0.001) and by 1.8 MAC (72 +/- 11) than by 1.2 MAC of sevoflurane (66 +/- 13; P < 0.001). In conclusion, equipotent concentrations of desflurane or sevoflurane in terms of BIS are associated with similar rSO2 values, but larger anesthetic concentrations of both anesthetics increased the rSO2 values.
authors.affiliation: Department of Anesthesiology, Aretaieion Hospital, Athens, Greece. afassou1@otenet.gr
authors.forename: Argyro
authors.initials: A
authors.lastname: Fassoulaki
authors.forename: Helen
authors.initials: H
authors.lastname: Kaliontzi
authors.forename: George
authors.initials: G
authors.lastname: Petropoulos
authors.forename: Athanassia
authors.initials: A
authors.lastname: Tsaroucha
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D002560:Cerebrovascular Circulation; D018592:Cross-Over Studies; D000077335:Desflurane; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D000077149:Sevoflurane; D019265:Spectroscopy, Near-Infrared
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D010100:Oxygen