title: Combo: a whole genome comparative browser.
abstract: CONCLUSIONS
  Combo is a comparative genome browser that provides a dynamic view of whole genome alignments along with their associated annotations. Combo provides two different visualization perspectives. The perpendicular (dot plot) view provides a dot plot of genome alignments synchronized with a display of genome annotations along each axis. The parallel view displays two genome annotations horizontally, synchronized through a panel displaying local alignments as trapezoids. Users can zoom to any resolution, from whole chromosomes to individual bases. They can select, highlight and view detailed information from specific alignments and annotations. Combo is an organism agnostic and can import data from a variety of file formats.
  
  
  BACKGROUND
  Combo is integrated as part of the Argo Genome Browser which also provides single-genome browsing and editing capabilities. Argo is written in Java, runs on multiple platforms and is freely available for download at http://www.broad.mit.edu/annotation/argo/.
authors.affiliation: The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu
authors.forename: Reinhard
authors.initials: R
authors.lastname: Engels
authors.forename: Tamara
authors.initials: T
authors.lastname: Yu
authors.forename: Chris
authors.initials: C
authors.lastname: Burge
authors.forename: Jill P
authors.initials: JP
authors.lastname: Mesirov
authors.forename: David
authors.initials: D
authors.lastname: DeCaprio
authors.forename: James E
authors.initials: JE
authors.lastname: Galagan
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D003628:Database Management Systems; D030541:Databases, Genetic; D016247:Information Storage and Retrieval / Q000379:methods; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface