title: [Clinical significance of anti-phosphatidylserine-prothrombin complex antibodies in antiphospholipid syndrome].
abstract: We clarified the clinical significance of IgG anti-phosphatidylserine-prothrombin complex (PS-PT) antibodies in the antiphospholipid syndrome (APS). The study population consisted of 122 patients with SLE and lupus-like disease. IgG anti-PS-PT antibodies were detected in 44% of 59 patients according to the diagnostic criteria by Harris and Hughes. This frequency was significantly (p < 0.005) higher than the 14% seen in patients without APS. IgG anti-PS-PT antibodies were strongly (p < 0.005) associated with thrombosis. In addition, IgG anti-PS-PT antibodies were positive in 64% of IgG beta2-GPI dependent anti-cardiolipin antibody negative APS patients under the Sapporo criteria. The above findings indicate that IgG anti-PS-PT antibodies as well as beta2,-GPI dependent anti-cardiolipin antibodies should be examined in the diagnosis of APS.
authors.affiliation: Department of Internal Medicine, Tokyo Electric Power Company Hospital.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kaburaki
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.forename: Hideto
authors.initials: H
authors.lastname: Kameda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Okada
authors.forename: Masao
authors.initials: M
authors.lastname: Katayama
authors.forename: Shunji
authors.initials: S
authors.lastname: Yoshida
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D010718:Phosphatidylserines / Q000276:immunology*; D011516:Prothrombin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D010718:Phosphatidylserines; D011516:Prothrombin