[Precocious puberty caused by McCune-Albright syndrome in a girl aged 6 years and 9 months].
The McCune-Albright syndrome is characterised by polyostotic fibrous dysplasia, "cafe-au-lait" spots and autonomous hyperfunction of various endocrine organs. The authors present the case of a girl at the age of 6 years 9 months with precocious puberty (thelarche III, menarche). High estradiol level (204 pg/ml) and low gonadoptopins concentration as well as their level after GnRH administration suggested ovarian autonomy. Ovarian cysts were found on pelvic ultrasound. Other endocrine abnormalities were excluded. Single "cafe-au-lait" spot was found on the patient skin. Scintigraphy, radiography and computed tomography scans showed fibrous dysplastic bones in the right tibia and in maxillary and sphenoid sinuses.
Wikiera
Beata
B
Klinika Endokrynologii i Diabetologii Wieku Rozwojowego AM we Wrocławiu, Wrocław. wikierab@wp.pl
Wawro
Józef
J
Noczyńska
Anna
A
D019080:Cafe-au-Lait Spots / Q000209:etiology; D002648:Child; D005147:Facial Bones / Q000000981:diagnostic imaging; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D010048:Ovarian Cysts / Q000601:surgery; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology*; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013977:Tibia / Q000000981:diagnostic imaging; D014463:Ultrasonography