title: Association of hypospadias and cardiac defect in a Parvovirus B19-infected stillborn: a causality relation?
abstract: Parvovirus B19 intrauterine infection is a known cause of hydrops fetalis and fetal death. It is also associated with congenital malformations, although the teratogenic potential seems to be low. Postmortem examination of a male stillborn of 29 gestational weeks revealed mild subcutaneous edema, malformed micropenis, perineoscrotal hypospadias and atrial septal defect, along with fetal erythroblastosis and villitis. Polymerase chain reaction detected Parvovirus B19 DNA genome in tissues from the fetus and the placenta, confirming the hypothesis of an intrauterine infection.
authors.affiliation: Department of Pathology, Medical School, National Kapodistrian University of Athens, 28, Narkisson Street, 152 33 Halandri, Athens, Greece. ankon@med.uoa.gr
authors.forename: A E
authors.initials: AE
authors.lastname: Konstantinidou
authors.forename: G
authors.initials: G
authors.lastname: Syridou
authors.forename: N
authors.initials: N
authors.lastname: Spanakis
authors.forename: A
authors.initials: A
authors.lastname: Tsakris
authors.forename: G
authors.initials: G
authors.lastname: Agrogiannis
authors.forename: E
authors.initials: E
authors.lastname: Patsouris
mesh_terms: D000015:Abnormalities, Multiple; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D004487:Edema; D005260:Female; D005313:Fetal Death; D006115:Greece; D006343:Heart Septal Defects / Q000150:complications*; D006344:Heart Septal Defects, Atrial; D006801:Humans; D007021:Hypospadias / Q000150:complications*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D010413:Penis / Q000473:pathology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D050497:Stillbirth
chemical_list: D004279:DNA, Viral