title: [Treatment of recurrent aphthous stomatitis with application of a preparation of a hesperidin 5.0%].
abstract: Open randomized 2-year trial has been performed to analyze effectiveness of Unguentum of a hesperidin developed by us for the treatment of recurrent aphthous stomatitis. 80 patients with recurrent aphthous stomatitis in the age from 15 till 60 years from the contingent of the polyclinic of the veterans of Tbilisi were studied. After inclusion of the preparation into the treatment the pain and duration of inflammatory process have been decreased; the complications were not observed. In the group of patients getting treatment with hesperidin, frequency of unsatisfactory outcomes decreased significantly (chi(2)=9,8, p < 0,05). Reduction of relative risk of unsatisfactory outcomes was about 0,8 (95% CI: 0,29-0,86), reduction of absolute risk - 0,33 (95% CI: 0,13-0,52). It may be concluded that application of a preparation may be considered as one of the options for the treatment of recurrent aphthous stomatitis.
authors.forename: Kh G
authors.initials: KhG
authors.lastname: Koridze
authors.forename: M S
authors.initials: MS
authors.lastname: Bakradze
authors.forename: K G
authors.initials: KG
authors.lastname: Shalashvili
authors.forename: L T
authors.initials: LT
authors.lastname: Aladashvili
authors.forename: I I
authors.initials: II
authors.lastname: Taboridze
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use; D006569:Hesperidin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055502:Secondary Prevention; D013281:Stomatitis, Aphthous / Q000188:drug therapy*
chemical_list: D005419:Flavonoids; D006569:Hesperidin