Effect of lamotrigine on cognition in children with epilepsy.
BACKGROUND
Lamotrigine does not affect cognition in healthy adult volunteers or adult patients with epilepsy, but its effect on cognition in children is uncertain.


OBJECTIVE
To compare the effect of lamotrigine and placebo on cognition in children with well-controlled or mild epilepsy.


METHODS
In a double-blind, placebo-controlled, crossover study, 61 children with well-controlled or mild epilepsy were randomly assigned to add-on therapy with either lamotrigine followed by placebo or placebo followed by lamotrigine. Each treatment phase was 9 weeks, the crossover period 5 weeks. A neuropsychological test battery was performed during EEG monitoring at baseline and at the end of placebo and drug phases. The paired Student' t test was used for statistical analysis for neuropsychological data (two tailed) with a p value of 0.01 considered significant. Carryover and period effect were analyzed with generalized linear modeling (SPSS 10).


RESULTS
Forty-eight children completed the study. Seizure frequency was similar during both treatment phases. No significant difference was found in continuous performance, binary choice reaction time, verbal and nonverbal recognition, computerized visual searching task, verbal and spatial delayed recognition, and verbal and nonverbal working memory between placebo and lamotrigine treatment phase. There was no significant carryover and period effect when corrected for randomization.


CONCLUSIONS
Lamotrigine exhibits no clinically significant cognitive effects in adjunctive therapy for children with epilepsy.
Pressler
R M
RM
Department of Clinical Neurophysiology, King's College Hospital, London, UK. ronit.pressler@uclh.org
Binnie
C D
CD
Coleshill
S G
SG
Chorley
G A
GA
Robinson
R O
RO
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008568:Memory / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects; D013037:Spatial Behavior / Q000187:drug effects; D016896:Treatment Outcome; D014227:Triazines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine