Non-vertebrate hosts in the analysis of host-pathogen interactions.
Mutations in bacterial pathogens have been isolated using many strategies. In contrast, the hosts they attack are significantly less tractable. To overcome this problem, a number of model host systems have been developed for isolation and investigation of mutations that modulate pathogen growth. These novel host models are either unicellular organisms, intact invertebrates or cells derived from invertebrates.
Dorer
Marion S
MS
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
Isberg
Ralph R
RR
D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000254:growth & development; D001424:Bacterial Infections / Q000382:microbiology*; D017173:Caenorhabditis elegans / Q000382:microbiology* / Q000502:physiology; D004023:Dictyostelium / Q000382:microbiology* / Q000502:physiology; D004331:Drosophila melanogaster / Q000382:microbiology* / Q000502:physiology; D009154:Mutation