title: DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.
abstract: The C-type lectin DC-SIGN is involved in early interactions between human innate immune cells and a variety of pathogens. Here we sought to evaluate whether DC-SIGN interacts with the leprosy bacillus, Mycobacterium leprae, and whether DC-SIGN genetic variation influences the susceptibility and/or pathogenesis of the disease. A case-control study conducted in a cohort of 272 individuals revealed no association between DC-SIGN variation and leprosy. However, our results clearly show that DC-SIGN recognizes M. leprae, indicating that mycobacteria recognition by this lectin is not as narrowly restricted to the Mycobacterium tuberculosis complex as previously thought. Altogether, our results provide further elucidation of M. leprae interactions with the host innate immune cells and emphasize the importance of DC-SIGN in the early interactions between the human host and the infectious agents.
authors.affiliation: CNRS FRE2849, Institut Pasteur, 25-28 rue Dr. Roux, Paris 75015, France.
authors.forename: Luis B
authors.initials: LB
authors.lastname: Barreiro
authors.forename: Hélène
authors.initials: H
authors.lastname: Quach
authors.forename: James
authors.initials: J
authors.lastname: Krahenbuhl
authors.forename: Shagufta
authors.initials: S
authors.lastname: Khaliq
authors.forename: Aisha
authors.initials: A
authors.lastname: Mohyuddin
authors.forename: S Qasim
authors.initials: SQ
authors.lastname: Mehdi
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gicquel
authors.forename: Olivier
authors.initials: O
authors.lastname: Neyrolles
authors.forename: Lluís
authors.initials: L
authors.lastname: Quintana-Murci
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D037102:Lectins / Q000235:genetics / Q000378:metabolism; D037181:Lectins, C-Type / Q000235:genetics* / Q000378:metabolism*; D007918:Leprosy / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D017720:Molecular Epidemiology; D009166:Mycobacterium leprae / Q000378:metabolism*; D010154:Pakistan / Q000453:epidemiology; D011153:Population / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin