title: [Anti-inflammatory action of myoinositol in renal insufficiency].
abstract: OBJECTIVE
  Release of prostaglandin E2 (PGE2) and leukotrien B4 (LTB4) in vitro by resting and PHA-stimulated peripheral blood mononuclear cells (PBMNC) in the presence of three concentrations of myoinositol (30, 300, 600 micromol/l) was investigated.
  
  
  METHODS
  We examinated 10 uremic patients on regular hemodialysis treatment and 10 healthy subjects (control group).
  
  
  RESULTS
  Release of PGE2 and LTB4 by resting and PHA-stimulated PBMNC was significantly lower in the presence of myoinositol in concentrations generally obserwed in the blood serum of chronic uraemic patients on regular hemodialysis treatment (600 micromol/l) in both investigated groups, while it remained unchanged in the presence of myoinositol in the concentration observed in normal blood serum (30 micromol/l).
  
  
  CONCLUSIONS
  The results seem to indicate that myoinositol, in the concentrations found in uremic blood serum, may possibly exert antiinflammatory actions.
authors.affiliation: Uniwersytet Medyczny w Lodzi, Uniwersytecki Szpital Kliniczny Nr 2. rb72@interia.pl
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
authors.forename: Piotr
authors.initials: P
authors.lastname: Bartnicki
authors.forename: Robert
authors.initials: R
authors.lastname: Błaszczak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kujawski
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Ciałkowska-Rysz
authors.forename: Robert
authors.initials: R
authors.lastname: Olszewski
authors.forename: Leszek
authors.initials: L
authors.lastname: Markuszewski
mesh_terms: D000328:Adult; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D014511:Uremia / Q000150:complications / Q000378:metabolism
chemical_list: D007975:Leukotriene B4; D007294:Inositol; D015232:Dinoprostone