[Expression of matrix metalloproteinase 2 in oral verruvous carcinoma and squamous cell carcinoma].
OBJECTIVE
To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma.


METHODS
Thirty cases were divided into 3 groups: verruvous carcinoma (n = 10), well-differentiated squamous cell carcinoma (n = 15) and moderately or poorly differentiated squamous cell carcinoma (n = 5). Reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of MMP2 mRNA in the carcinoma tissues and matched normal tissues from 3 groups above.


RESULTS
The expression of MMP2 mRNA in the carcinoma tissues was significantly higher than that in their matched normal tissues (P < 0.05). The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P < 0.05). However, the expression of MMP2 mRNA was not obviously different between well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P > 0.05).


CONCLUSIONS
The expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma tissues was significantly higher than that in their matched normal tissues. The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in squamous cell carcinoma.
Tang
Zhan-gui
ZG
Departerment of Oral and Maxillofacial Sturgery, Xiangya Hospital, Central South University, Changsha 410008, China. Tangzhangui@yahoo.com.cn
Li
Jin-mao
JM
Hong
Zhen-zhen
ZZ
Yu
Zhi-wei
ZW
Liu
Cheng-hui
CH
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D018289:Carcinoma, Verrucous / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D012333:RNA, Messenger; D020778:Matrix Metalloproteinase 2