Endosomal and non-endosomal functions of ESCRT proteins.
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.
Slagsvold
Thomas
T
Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N-0310 Oslo, Norway.
Pattni
Krupa
K
Malerød
Lene
L
Stenmark
Harald
H
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000502:physiology*; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000502:physiology; D011499:Protein Processing, Post-Translational; D021381:Protein Transport / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D022161:Transport Vesicles / Q000378:metabolism / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D018406:Virus Physiological Phenomena; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D046912:Multiprotein Complexes; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D033921:Vesicular Transport Proteins; D000099177:Tsg101 Protein