[Influence of treatment of inhaled corticosteroids on the function of the larynx in asthmatic patients].
The objective of the study was to examine influence of inhaled glycocorticosteroids on phoniatric function of the larynx in patients suffering from asthma.


METHODS
Thirty minutes after the administration and long-term therapy effect of the inhaled glycocorticosteroids on local condition of the phoniatric organ was assessed in 15 patients with recently diagnosed bronchial asthma. The diagnostics of asthma included: subjective and objective examination, prick tests, spirometry, total IgE and histamine test for bronchial hyperactivity. Evaluation of voice function was implemented subjectively and objectively with use of videolaryngostroboscopy (VLSS). Acoustic assessment of voice was also performed.


RESULTS
Administration of glycocorticosteroids as inhaled discs resulted in incidents of cough, mouth and throat dryness, sensation of polydipsia and skin inflammation around the mouth. Occasionally, hoarseness and discomfort in the larynx area were noted. On long-term administration, dysphonia, hoarseness and voice fatigue due to dysfunction of innermost larynx muscles, particularly vocal fold adductors. After 30 minutes of the glycocorticosteroid administration in patients with recently diagnosed asthma, irritation of the pharynx and larynx mucosa was recorded.


CONCLUSIONS
The long-term treatment with inhaled glycocorticosteroids resulted in myopathy of proper muscles of the larynx.
Kosztyła-Hojna
Bozena
B
Akademia Medyczna w Białymstoku, Klinika Otolaryngologii, Poradnia Foniatryczna. otol@amb.edu.pl
Rogowski
Marek
M
Rutkowski
Ryszard
R
Pepiński
Witold
W
Ryćko
Przemysław
P
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007819:Laryngeal Edema / Q000139:chemically induced* / Q000503:physiopathology; D007830:Larynx / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000209:etiology / Q000503:physiopathology*; D010699:Phonation / Q000187:drug effects*; D013061:Speech Acoustics; D014833:Voice Quality
D000305:Adrenal Cortex Hormones