Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography.
A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.
Bae
Youn-Sang
YS
Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea.
Lee
Chang-Ha
CH
D000465:Algorithms; D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D015203:Reproducibility of Results; D013237:Stereoisomerism