[Characteristics of p53 protein stabilization in cells of patients with ataxia-telangiectasia after gamma-irradiation].
Stabilization of P53 protein in cells isolated from patients with a grave hereditary disease ataxia-telangiectasia (AT), characterized by strongly enhanced sensitivity to ionizing radiation and impairment of cell cycle control after DNA damage, was studied. The level of expression of these reactions by patients may vary, and it tends to be linked with the severity of the disease. In all AT strains studied, both acquired by the authors and obtained from foreign colleagues, we observed the alteration of timing and character of stabilization of P53 protein, after the action of ionizing radiation in sublethal dosage, as compared to that in cells from healthy donor.
Spivak
I M
IM
Smirnova
N V
NV
Pleskach
N M
NM
Ledashcheva
T A
TA
Mikhel'son
V M
VM
D001260:Ataxia Telangiectasia / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53