SUMO: a ubiquitin-like protein modifier.
SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progression, and DNA damage recovery. Defects in the SUMO pathway have been demonstrated to affect tumorigenesis and the inflammatory response as well as other human diseases.
Kroetz
Mary B
MB
Department of Cell Biology, Yale University, New Haven, Connecticut 06520, USA. mary.kroetz@yale.edu
D000818:Animals; D002453:Cell Cycle; D002875:Chromosomes / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D007249:Inflammation; D008239:Lysine / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism; D011485:Protein Binding; D025842:SUMO-1 Protein / Q000378:metabolism / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D025801:Ubiquitin / Q000737:chemistry
D025842:SUMO-1 Protein; D025801:Ubiquitin; D008239:Lysine