Caulerpenyne-colchicine hybrid: synthesis and biological evaluation.
The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.
Bourdron
Julien
J
UMR-CNRS 6178 SymBio, équipe Synthèse par voie Organométallique, Université Paul Cézanne (Aix-Marseille III), Marseille, France.
Commeiras
Laurent
L
Barbier
Pascale
P
Bourgarel-Rey
Véronique
V
Pasquier
Eddy
E
Vanthuyne
Nicolas
N
Hubaud
Jean-Claude
JC
Peyrot
Vincent
V
Parrain
Jean-Luc
JL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003078:Colchicine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D011108:Polymers / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000187:drug effects* / Q000378:metabolism
D000970:Antineoplastic Agents; D011108:Polymers; D012717:Sesquiterpenes; D014404:Tubulin; C097889:caulerpenyne; D003078:Colchicine