Beta-adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle.
Daily oral administration of isoproterenol hydrochloride (60 mg/kg body weight; for 30 days) a beta-receptor agonist to normal innervated and denervated adult male Swiss albino mice confirmed its ability to induce skeletal muscle hypertrophy and reverse denervation atrophy respectively. Measurement of total tissue proteins and dry muscle mass showed 15-17% increase with 6% rise of hypertrophy index in gastrocnemius muscle. Hydroxyproline assay employed to measure the total tissue collagen exhibited 45% increase in collagen in normal innervated gastrocnemius muscle in response to beta agonist treatment. beta-adrenoceptor agonist ameliorated denervation atrophy along with further increase in collagen content of denervated gastrocnemius muscle.
Kumar
Rakesh
R
Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla 171 005, India.
Katoch
Surender S
SS
Sharma
Sushma
S
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D003714:Denervation; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism / Q000473:pathology
D000318:Adrenergic beta-Agonists; D003094:Collagen