[A case of hepatoid carcinoma of the pancreas].
Hepatoid carcinoma is a primary extrahepatic neoplasm exhibiting features of hepatocellular carcinoma (HCC) in terms of morphology, immunohistochemistry, and behavior. In many cases, tumor cytoplasm is positive for alpha- fetoprotein (alpha-FP) with elevated serum alpha-FP level. Because not all hepatoid carcinomas are associated with alpha- FP overproduction, diagnosis should be made essentially by histological features of the tumor. We present a case of hepatoid carcinoma of the pancreas in a 21-year-old male patient. Abdominal computed tomography and magnetic resonance imaging revealed an inhomogeneously enhanced pancreatic head mass. Serum alpha-FP level was markedly elevated. He underwent pylorus-preserving Whipple's operation. The tumor showed hepatoid and neuroendocrine components simultaneously. The histopathological diagnosis was hepatoid carcinoma associated with neuroendocrine tumor of the pancreas. Seven months after the surgery, the patient is healthy without evidence of recurrence. To date, only 7 cases of hepatoid carcinoma of the pancreas have been reported in the literature, and this is the first case report in Korea.
Oh
Hyun Jong
HJ
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Cheung
Dae Young
DY
Kim
Tae Ho
TH
Kim
Soon Sub
SS
Kim
Myoung Seok
MS
Kim
Jin Il
JI
Park
Soo Heon
SH
Han
Joon Yeol
JY
Han
Nam Ik
NI
Kim
Jae Kwang
JK
Lee
Young Sok
YS
Kim
Eung Kook
EK
Jung
Eun Sun
ES
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology