Recent advances in clarifying prion protein functions using knockout mice and derived cell lines.
Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrP(C)), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.
Sakudo
Akikazu
A
Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
Onodera
Takashi
T
Suganuma
Yoshikazu
Y
Kobayashi
Takanori
T
Saeki
Keiichi
K
Ikuta
Kazuyoshi
K
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002460:Cell Line; D018390:Gene Targeting; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism; D011328:Prions / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation
D011328:Prions