title: Changes in brain volume 2 years after extracranial-intracranial bypass surgery: A preliminary subanalysis of the Japanese EC-IC trial.
abstract: METHODS
  We studied changes in brain volume on magnetic resonance imaging in 10 patients with and without extracranial-intracranial (EC-IC) bypass surgery who met the inclusion criteria for the Japanese EC-IC Bypass Trial, a multicenter, randomized, prospective study of patients with hemodynamic brain ischemia due to cerebral artery occlusive disease. We also examined the association of cerebral hemodynamics on single-photon emission computed tomography with the changes in brain volume.
  
  
  RESULTS
  The affected/unaffected ratio of the percent brain volume declined in patients without EC-IC bypass surgery (p < 0.02, n = 4), and the affected/unaffected percent regional cerebral blood flow ratio increased in patients with the surgery (p < 0.03, n = 6). Acetazolamide reactivity increased in the affected hemisphere of patients with surgery (p < 0.01). Two-year increase (decrease) in acetazolamide reactivity of the affected hemisphere showed a significant positive correlation with 2-year changes in the affected/unaffected percent brain volume ratio (R2 = 0.737, p = 0.0007).
  
  
  CONCLUSIONS
  Change in acetazolamide reactivity might be a good predictor for brain atrophy in cerebral artery occlusive disease.
authors.affiliation: Department of Cerebrovascular Disease, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Juro
authors.initials: J
authors.lastname: Jinnouchi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Toyoda
authors.forename: Tooru
authors.initials: T
authors.lastname: Inoue
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Gotoh
authors.forename: Kotaro
authors.initials: K
authors.lastname: Yasumori
authors.forename: Setsuro
authors.initials: S
authors.lastname: Ibayashi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000086:Acetazolamide; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D002539:Cerebral Arterial Diseases / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D016032:Randomized Controlled Trials as Topic; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D000086:Acetazolamide