Improving reliability and performance of DNA microarrays.
A great many platforms and versions of the microarray technology, with different characteristics and applications, have been developed. This review will describe some key issues in reliability and performance with the two most commonly used platforms for gene expression analysis, in situ-synthesized oligonucleotide microarrays or GeneChips and spotted microarrays. Some recent advances and new applications within the field will be mentioned briefly.
Sievertzon
Maria
M
Royal Institute of Technology, AlbaNova University Center, KTH Genome Center, Department of Biotechnology, S-106 91 Stockholm, Sweden. maria.sievertzon@biotech.kth.se
Nilsson
Peter
P
Lundeberg
Joakim
J
D018076:DNA, Complementary / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry; D015203:Reproducibility of Results
D018076:DNA, Complementary; D009841:Oligonucleotides