The antigen recognized by MOMA-I is sialoadhesin.
The monoclonal antibody MOMA-1 is a widely-used marker for marginal metallophilic macrophages in spleen and some other subsets of macrophages. The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family. Using flow cytometry of Sn-transfected cells and staining of lymphoid tissue sections from Sn-deficient mice, we demonstrate here that the antigen recognized by MOMA-1 is Sn.
Oetke
Cornelia
C
The Wellcome Trust Biocentre, Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, UK. c.oetke@dundee.ac.uk
Kraal
Georg
G
Crocker
Paul R
PR
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D016466:CHO Cells; D006224:Cricetinae; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D063267:Sialic Acid Binding Ig-like Lectin 1
D000911:Antibodies, Monoclonal; D000941:Antigens; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1; C571167:Siglec1 protein, mouse