A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy.
We describe a patient with acute oropharyngeal-facial diplegia, tongue palsy and albuminocytological dissociation following upper respiratory tract infection. Electrophysiological abnormalities in blink reflex suggested a brainstem lesion. High titers of anti-GM3, GD1a and GT1b IgG class serum antibodies were initially detected. Absorption studies indicated that antibodies were directed to a common terminal epitope NeuNAc(alfa 2-3)Gal. This novel antiganglioside antibody specificity may play a role in this unusual regional form of acute bulbar palsy of possible central origin. These data are supportive for extending the panel of antiganglioside specificities with anti-GM3.
Rojas-Garcia
Ricard
R
Department of Neurology, Hospital de la Sta. Creu i St. Pau and Institut de Recerca HSCSP, Universitat Autònoma de Barcelona, Barcelona, Sant Antoni Maria Claret 167 08025, Spain. rrojas@santpau.es
Martinez-Lage
Maria
M
Gallardo
Eduard
E
de Luna
Noemi
N
Marti-Vilalta
Josep-Lluis
JL
Diaz-Manera
Jordi
J
Juarez
Candido
C
Blesa
Rafael
R
Illa
Isabel
I
D000208:Acute Disease; D000918:Antibody Specificity; D010244:Bulbar Palsy, Progressive / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005679:G(M3) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005679:G(M3) Ganglioside; D005732:Gangliosides; C021298:ganglioside, GD1a; C016481:trisialoganglioside GT1