title: Effects of different sizes of beta-tricalcium phosphate particles on bone augmentation within a titanium cap in rabbit calvarium.
abstract: This study evaluated the effects of different sizes of beta-TCP particles on bone augmentation within a titanium cap. In 20 rabbits, the calvarium was exposed and a circular groove was prepared. After marrow penetration, a standardized hemispherical titanium cap was placed in the circular grove. The cap was filled with small-sized (100-250 microm) or medium-sized (250-500 microm) beta-TCP particles for the experimental site and without beta-TCP for the control site. After one and three months of healing, the animals were euthanized and examined histologically. There was a statistically significant difference in the amount of mineralized bone generated between the experimental and control groups in the three-month specimens. Furthermore, the medium-sized particles showed significantly more mineralized bone than did the small-sized particles. Based on these findings, we suggested that beta-TCP might be effective for bone formation and that medium-sized particles are more useful than small-sized particles in bone maturation.
authors.affiliation: Nihon University Graduate School of Dentistry.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Murai
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Fukase
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamada
authors.forename: Kazuo
authors.initials: K
authors.lastname: Komiyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D008297:Male; D010316:Particle Size; D011817:Rabbits; D012886:Skull / Q000601:surgery*; D018709:Statistics, Nonparametric
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate