Unilateral hemispherectomy at adulthood asymmetrically affects immobile behavior of male Swiss mice.
In order to test the hypothesis that behavioral coping with stressful situations is asymmetrically modulated by the hemispheres, we used the unilateral hemispherectomy procedure to assess the relative importance of each hemisphere in the determination of the immobility time during the forced swimming test. Under anesthesia, adult Swiss male mice were submitted to unilateral (right or left) hemispherectomy or sham surgery. Fifteen days after surgery, the immobile and turning behaviors of each mouse were measured during a 5-min forced swimming testing session. In general, while turning activity decreased significantly as the test progressed, an increase in immobility was observed. The unilateral hemispherectomy asymmetrically affected the immobility time in the forced swimming test. Particularly, the increase in immobility time of right-hemispherectomized mice was greater than that observed for sham-operated ones. In contrast, there were no differences in turning activity between the groups. The higher immobility time in males that had their right hemisphere removed supports the hypothesis that the two hemispheres contribute differentially to the behavioral response to stress.
Filgueiras
Cláudio C
CC
Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcântara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Avenida Prof. Manuel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro, RJ 20 550 170, Brazil. ccfilg@uerj.br
Abreu-Villaça
Yael
Y
Krahe
Thomas E
TE
Manhães
Alex C
AC
D000818:Animals; D001921:Brain / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D038421:Hemispherectomy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D013550:Swimming / Q000523:psychology