Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.
Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice.
Orlova
Marianna O
MO
Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza Alley 2, Moscow 107564, Russia. asapt@aha.ru.
Majorov
Konstantin B
KB
Lyadova
Irina V
IV
Eruslanov
Eugenii B
EB
M'lan
Cyr E
CE
Greenwood
Celia M T
CM
Schurr
Erwin
E
Apt
Alexander S
AS
D000818:Animals; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D014376:Tuberculosis / Q000235:genetics*
D018925:Chemokines; D016207:Cytokines