title: Severe juvenile dermatomyositis: two patients complicated with extra musculocutaneous involvement.
abstract: Here we report two patients with severe juvenile dermatomyositis (JDM) complicated with extra musculocutaneous involvement. The first case (a 10-year-old boy) had unusual initial presentation of JDM complicated with interstitial lung disease documented with high-resolution computed tomography. He had a rapidly progressive course and died in 7 weeks after the onset of the disease despite steroid and immunosuppressive treatment. The second case (a 14-year-old boy) was presented with myositis complicated with hepatitis. He also had a chronic course of JDM with unfavorable outcome. It appears that the prognosis of patients with severe JDM is related with the degree of autoimmune vasculitis on extra musculocutaneous involvement.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Ege University Medical School, Bornova, Izmir 35100, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Tosun
authors.forename: Gül
authors.initials: G
authors.lastname: Serdaroğlu
authors.forename: Mehmet Tayyip
authors.initials: MT
authors.lastname: Aslan
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Polat
authors.forename: Taner
authors.initials: T
authors.lastname: Akalin
authors.forename: Hasan
authors.initials: H
authors.lastname: Tekgul
authors.forename: Sarenur
authors.initials: S
authors.lastname: Gökben
mesh_terms: D000293:Adolescent; D002648:Child; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis*; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D014657:Vasculitis / Q000209:etiology
chemical_list: D011239:Prednisolone