[The content condition of effective composition in Sanhuang Xiexin decoction].
OBJECTIVE
To investigate the content and existing conditions of baicalin, berberine and rhein in Sanhuang Xiexin decoction suspension.


METHODS
Three active components (baicalin, berberine and rhein) in different prescriptions of original, absentone ingredient herb, and single herb were determined by HPLC.


RESULTS
There were baicalin 1,211 mg, berberine 276 mg and rhein 25 mg in 200 mL Sanhuang Xiexin decoction. Even though there will be precipitation if alkaloid is together with baicalin and some anthraquinones, no obvious interaction showed the affecting extract content between Scutellaria baicalensis and Coptis chinensis. The extracted rhein content can be increased obviously by Scutellaria baicalensis. Rheum patmatum and Coptis chinensis can suppress medicinal composition release of each other.


CONCLUSIONS
The acid and basic components can affect each other and the acid components themselves also can affect each other.
Li
Yi
Y
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Xu
Xu
X
D000880:Anthraquinones / Q000032:analysis* / Q000737:chemistry; D001599:Berberine / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004347:Drug Interactions; D005419:Flavonoids / Q000032:analysis* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012250:Rheum / Q000737:chemistry; D031364:Scutellaria baicalensis / Q000737:chemistry
D000880:Anthraquinones; D004338:Drug Combinations; D005419:Flavonoids; D001599:Berberine; C038044:baicalin; C020491:rhein