[Harmonisation of validation strategies and estimation of the associated uncertainty in the framework of assay laboratoires accreditation].
In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an analytical procedure is described: the accuracy profile based on the estimation of the total error of the measurements. This profile build with beta-expectation tolerance intervals can also compute with efficiency the uncertainty related to the results of a laboratory, which is an essential parameter for the accreditation of laboratories under ISO 17025.
Hubert
P
P
Laboratoire de Chimie Analytique, Institut de Pharmacie, Université de Liege, Avenue de l'Hôpital, 1 Bat. B36, 4000 Liège, Belgique. Ph.Hubert@ulg.ac.be
Rozet
E
E
Boulanger
B
B
Dewé
W
W
Laurentie
M
M
Dubois
N
N
Charlier
C
C
Feinberg
M
M
D000068:Accreditation; D007753:Laboratories / Q000592:standards*; D012015:Reference Standards; D035501:Uncertainty