Primary hyperaldosteronism: effect of adrenal vein sampling on surgical outcome.
OBJECTIVE
Adrenal vein sampling is superior to computed tomography for subtype differentiation of primary hyperaldosteronism.


METHODS
Retrospective review.


METHODS
University medical center.


METHODS
Forty-eight patients (32 men and 16 women) with biochemically confirmed primary hyperaldosteronism.


METHODS
We compared demographic factors, results of biochemical and imaging studies (computed tomography and adrenal vein sampling), therapy, and patient outcomes.


RESULTS
Mean +/- SEM adrenal nodule size was 1.54 +/- 0.2 cm. Adrenal vein sampling was performed in 41 (85%) of 48 patients, and it was successful in 39 (95%) of those 41 patients. Concordance between computed tomography and adrenal vein sampling was observed in 22 (54%) of the 41 patients. Thirty-two patients underwent successful laparoscopic adrenalectomy. There was 1 complication and no deaths. All 32 patients were cured of hypokalemia.


CONCLUSIONS
Adrenal vein sampling is superior to image-based techniques for subtype differentiation of primary hyperaldosteronism.
Nwariaku
Fiemu E
FE
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75390-9156, USA. fiemu.nwariaku@utsouthwestern.edu
Miller
Barbra S
BS
Auchus
Richard
R
Holt
Shelby
S
Watumull
Lori
L
Dolmatch
Bart
B
Nesbitt
Shawna
S
Vongpatanasin
Wanpen
W
Victor
Ronald
R
Wians
Frank
F
Livingston
Edward
E
Snyder
William H
WH
D000311:Adrenal Glands / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000601:surgery; D000315:Adrenalectomy; D000450:Aldosterone / Q000097:blood; D002406:Catheterization, Peripheral; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014680:Veins
D000450:Aldosterone