Evaluation of antioxidant activity and potential toxicity of 1-buthyltelurenyl-2-methylthioheptene.
The aim of the present study was to evaluate pharmacological and toxicological properties of 1-buthyltelurenyl-2-methylthioheptene (compound 1). In vitro, compound 1 at 1 microM was effective in reducing lipid peroxidation induced by Fe/EDTA. Compound 1 presented neither thiol peroxidase nor thiol oxidase activity and did not change delta-ALA-D (delta-aminolevulinate dehydratase) activity (10-400 microM). Calculated LD(50) of compound 1, administered by oral route, was 65.1 micromol/kg. Rats treated with compound 1 did not reveal any motor impairment in the open field. Hepatic, renal and cerebral lipid peroxidation in treated rats did not differ from those in control rats. Conversely, 0.5 micromol/kg of compound 1 decreased lipid peroxidation in spleen. Delta-ALA-D activity in liver and spleen was inhibited in rats treated with the higher dose of compound 1 but no significant differences were detected in renal delta-ALA-D activity. AST (aspartate aminotransferase) and ALT (alanine aminotransferase) activities as well as urea and creatinine levels were increased by high doses of compound 1 (50-75 micromol/kg). Compound 1 induced a significant decrease in plasma triglyceride levels but none of the doses tested changed the cholesterol level. This is a promising compound for more detailed pharmacological studies involving organotellurium compounds.
Savegnago
Lucielli
L
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
Borges
Vanessa C
VC
Alves
Diego
D
Jesse
Cristiano R
CR
Rocha
Joao B T
JB
Nogueira
Cristina W
CW
D000410:Alanine Transaminase / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D001219:Aspartate Aminotransferases / Q000187:drug effects; D004492:Edetic Acid / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000633:toxicity; D010544:Peroxidases / Q000187:drug effects; D000623:Porphobilinogen Synthase / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013691:Tellurium / Q000494:pharmacology* / Q000633:toxicity; D014280:Triglycerides / Q000097:blood
C514500:1-butyltellurenyl-2-methylthioheptene; D000975:Antioxidants; D009942:Organometallic Compounds; D014280:Triglycerides; D004492:Edetic Acid; D007501:Iron; D010544:Peroxidases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000623:Porphobilinogen Synthase; D013691:Tellurium