Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenase in vitro.
The effect of methanol and aqueous methanol extract of Origanum vulgare L. ssp. hirtum on aldose reductase and soybean lipoxygenase was investigated. The results revealed a promising potential of oregano for preventing diabetes complications in the long term and an antiinflammatory efficacy by inhibiting soybean lipoxygenase.
Koukoulitsa
Catherine
C
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.
Zika
Chariklia
C
Hadjipavlou-Litina
Dimitra
D
Demopoulos
Vassilis J
VJ
Skaltsa
Helen
H
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D000432:Methanol / Q000737:chemistry; D031341:Origanum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology; D013025:Glycine max / Q000201:enzymology*
D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D010940:Plant Proteins; D000449:Aldehyde Reductase; D008084:Lipoxygenase; D000432:Methanol