title: Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice.
abstract: Neuropeptide Y (NPY) was shown to modulate anxiety- and depression-related behaviors in various animal models. Previous studies demonstrated that NPY Y2 receptor knockout (KO) mice display an anxiolytic- and antidepressant-like phenotype compared with control animals. However, the long-term effect of the deletion of this receptor in aged animals is unknown. Thus, anxiety- and depression-related behaviors were investigated in 2-yr-old NPY Y2 KO mice. Aged NPY Y2 KO mice display an anxiolytic-like profile as assessed in the elevated plus-maze and open field, providing further support for a role for Y2 receptors in anxiety-related behaviors. Furthermore, aged NPY Y2 KO mice have significantly lower immobility scores in the forced swim test; supporting the role for this receptor in antidepressant-like behaviors. These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects.
authors.affiliation: Douglas Hospital Research Centre, Department of Neurology and Neurosurgery, Department of Psychiatry, McGill University, Montréal QC, Canada H4H 1R3.
authors.forename: Cristina
authors.initials: C
authors.lastname: Carvajal
authors.forename: Yvan
authors.initials: Y
authors.lastname: Dumont
authors.forename: Herbert
authors.initials: H
authors.lastname: Herzog
authors.forename: Rémi
authors.initials: R
authors.lastname: Quirion
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D010641:Phenotype; D051381:Rats; D017476:Receptors, Neuropeptide Y / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors
chemical_list: D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor