title: Total synthesis of (-)-mucocin.
abstract: [reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments.
authors.affiliation: Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, 27599, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Crimmins
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Frank A
authors.initials: FA
authors.lastname: Diaz
mesh_terms: D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D031045:Rollinia / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D011714:Pyrans; C413144:mucocin