title: Production of ultra-fine bioresorbable carbonated hydroxyapatite.
abstract: Ionic-substituted hydroxyapatite (HAp) based materials may be a better choice than pure HAp owing to their similarity in chemical composition with biological apatite. The present study reports a process for the production of carbonated hydroxyapatite (CHAp) using microwaves. The CHAp was evaluated for its phase purity, chemical homogeneity, functionality, morphology, and solubility. The CHAp thus obtained was compared with a pure HAp and a biological apatite, which provides quite an interesting insight into the carbonate substitution. The in vitro ionic dissolution rates determined under physiological conditions clearly demonstrate the soluble nature of CHAp compared to HAp. The overall results indicate that the processed CHAp has increased resorption relative to pure HAp and has a chemical composition corresponding to some extent with that of biological apatite.
authors.affiliation: NUS Nanoscience and Nanotechnology Initiative, Division of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore. engmr@nus.edu.sg
authors.forename: R
authors.initials: R
authors.lastname: Murugan
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials; D016207:Cytokines; D007700:Kinetics; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D016207:Cytokines; C025940:bone resorption factor; C030782:carboapatite