[Effects of slenderstyle Acanthopanax root-bark on cyclooxygenase].
OBJECTIVE
To explore the effects of slenderstyle acanthopanax root-bark on cyclooxygenase in vivo and in vitro.


METHODS
Contents of 6-keto-PGF1alpha in bovine aorta endothelial cells, PGE2 in mouse abdominal macrophages, and 6-keto-PGF1alpha in rat stomach tissue were determined. The ulcer index in rat gastric mucosa was measured.


RESULTS
COX-1 and COX-2 were inhibited by slenderstyle acanthopanax root-bark, and the inhibitive rate of COX-2 was higher than that of COX-1 at the same concentration. Necrotic injuries in health gastric mucosa were not produced, but the injuries previously induced by the ethanol worsened.


CONCLUSIONS
One of the antirheumatic mechanisms of slender-root-bark might probably be mediating through inhibition of cyclooxygenase. style acanthopanax
Qiu
Jian-Bo
JB
GuangZhou QiaoGuang Pharmaceutical Co. Ltd. , Guangzhou 510140, China.
Long
Qi-Cai
QC
Yao
Mei-Cun
MC
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000201:enzymology; D002417:Cattle; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D028001:Eleutherococcus / Q000737:chemistry; D042783:Endothelial Cells / Q000201:enzymology; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology; D017737:Macrophages, Peritoneal / Q000201:enzymology; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D015121:6-Ketoprostaglandin F1 alpha; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D015232:Dinoprostone