Topical imiquimod: mechanism of action and clinical applications.
Imiquimod is a synthetic imidazoquinoline heterocyclic amine of 240.3 Da (C14H16N4). Imiquimod is a cytokine inducer and a modifier of the innate immune response, as well as acquired antiviral and antitumor immune responses. Imiquimod 5% cream has proven to be an effective treatment for external genital warts, superficial basal cell carcinoma, and actinic keratosis.
Vidal
David
D
Department of Dermatology, Hospital Dos de Maig, Barcelona, Spain. 33053dvs@comb.es
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D000077271:Imiquimod
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod