[Growth failure in a boy with Klinefelter syndrome and IUGR].
BACKGROUND
Children born with a history of Intra-Uterine Growth Retardation (IUGR) may be susceptible for reduced growth velocity and growth deficiency. The causes of GH/IGF-1 resistance are unknown. Klinefelter syndrome is characterized by excessive growth, resulting from hypogonadism, open bone age and a prolonged growth.


OBJECTIVE
The case of a 6-year-old boy with Klinefelter syndrome born with IUGR and deep growth deficiency was studied.


METHODS
A 6-year-old boy with birth weight 2300 g born of term in 38 Hbd is presented. The cariotype was 47XXY. The phenotype was typical for a child with IUGR. GH in the clonidin test was 37.4 microIU/ml, IGF-1 -- 111 ng/ml. Increased IGF-1 level from 178.1 ng/ml to 360.9 ng/ml was founded in the IGF-1 generation test.


CONCLUSIONS
The cause of growth deficiency in this case could be GH/IGF-1 resistance.
Korpysz
Alicja
A
Oddział Endokrynologii Kliniki Pediatrii Instytutu "Pomnik Zdrowia Dziecka" w Warszawie, Warszawa.
Szalecki
Mieczysław
M
D001827:Body Height / Q000235:genetics; D002648:Child; D005183:Failure to Thrive / Q000235:genetics* / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000235:genetics* / Q000378:metabolism; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000378:metabolism; D007713:Klinefelter Syndrome / Q000235:genetics* / Q000378:metabolism; D008297:Male
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I