CCR6(+) dendritic cells: the gut tactical-response unit.
How an immune response to pathogens is initiated in the gut is still an open question. In this issue of Immunity, it has been found that a distinct subset of CCR6-expressing dendritic cells are absolutely required to activate anti-Salmonella-specific T cells.
Rescigno
Maria
M
Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy.
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology / Q000382:microbiology; D008213:Lymphocyte Activation / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D054399:Receptors, CCR6; D019707:Receptors, Chemokine / Q000378:metabolism*; D012475:Salmonella / Q000276:immunology; D012480:Salmonella Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
C498126:CCR6 protein, mouse; D054399:Receptors, CCR6; D019707:Receptors, Chemokine