title: 17 salts of ephedrine: crystal structures and packing analysis.
abstract: The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour.
authors.affiliation: Molecular Materials Centre, School of Chemical Engineering and Analytical Science, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, England.
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Collier
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Davey
authors.forename: Simon N
authors.initials: SN
authors.lastname: Black
authors.forename: Ron J
authors.initials: RJ
authors.lastname: Roberts
mesh_terms: D000143:Acids / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D004809:Ephedrine / Q000737:chemistry*; D008968:Molecular Conformation; D012492:Salts / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000143:Acids; D002264:Carboxylic Acids; D012492:Salts; D013451:Sulfonic Acids; D004809:Ephedrine