title: Biophysical effects of repetitive removal of adhesive dressings on peri-ulcer skin.
abstract: OBJECTIVE
  To study the effect of repeated removal of four different adhesive dressings on peri-ulcer skin using quantitative non-invasive techniques.
  
  
  METHODS
  Forty-five patients with open (n = 29) or healed (n = 16) venous leg ulcers were included. Peri-ulcer skin was treated for 14 days with patches of two different hydrocolloid-based adhesive dressings, one polyurethane adhesive and one soft silicone adhesive dressing. Normal skin of the patients' ventral forearm was also treated identically. Adhesive patches of the dressings were replaced every second day. The skin barrier function was assessed by measuring transepidermal water loss and stratum corneum hydration by measuring electrical conductance.
  
  
  RESULTS
  Thirty-nine patients completed the study. The hydrocolloid adhesives increased transepidermal water loss and conductance while the polyurethane and soft silicone adhesives did not influence these parameters significantly compared with adjacent non-treated peri-ulcer skin. For normal forearm skin, similar relative effects among the four adhesives were found.
  
  
  CONCLUSIONS
  Repetitive treatment with hydrocolloid-based adhesive dressings induced major functional alterations of the stratum corneum. In contrast, a polyurethane adhesive and a soft silicone adhesive dressing did not alter transepidermal water loss or conductance of peri-ulcer skin.
authors.affiliation: Copenhagen Wound Healing Centre, I Bispebjerg Hospital, Copenhagen, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Zillmer
authors.forename: M S
authors.initials: MS
authors.lastname: Agren
authors.forename: F
authors.initials: F
authors.lastname: Gottrup
authors.forename: T
authors.initials: T
authors.lastname: Karlsmark
mesh_terms: D000269:Adhesives / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages / Q000009:adverse effects; D047070:Bandages, Hydrocolloid; D003872:Dermatitis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011140:Polyurethanes; D012828:Silicones; D014647:Varicose Ulcer / Q000628:therapy*; D014870:Water Loss, Insensible
chemical_list: D000269:Adhesives; D011140:Polyurethanes; D012828:Silicones