Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes.
Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light. However, a clear understanding of ubiquitin-dependent protein localization cannot be achieved without knowledge of the role of deubiquitylating enzymes (DUBs). DUBs, by definition, function downstream in ubiquitin pathways and, as such, have the potential to be the final editors of protein ubiquitylation status, thus determining substrate fate. This paper assimilates the current evidence concerning the substrates and activities of DUBs that regulate protein trafficking.
Millard
Susan M
SM
Child Health Research Institute, North Adelaide, South Australia 5006, Australia.
Wood
Stephen A
SA
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D017874:Immediate-Early Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; C099271:Dub1 protein, mouse; D010450:Endopeptidases