Pathobiology of idiopathic ascending aortic aneurysms.
The majority of ascending aortic aneurysms cannot be related to any specific etiology and should be qualified as idiopathic. The pathobiology of ascending aortic aneurysms remains incompletely understood. Data from direct study are still scarce and often limited because of patient heterogenicity. Currently available information suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression. Further understanding of these mechanisms will likely provide novel diagnostic, prognostic, and therapeutical tools for the clinician.
Kirsch
E W Matthias
EW
Department of Cardiothoracic Surgery, Hospital Henri Mondor, 51 Avenue Mal de Lattre de Tassigny, Créteil Cedex 94 000, France. matthias.kirsch@hmn.aphp.fr
Radu
N Costin
NC
Allaire
Eric
E
Loisance
Daniel Y
DY
D001011:Aorta / Q000473:pathology / Q000503:physiopathology*; D001014:Aortic Aneurysm / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009389:Neovascularization, Pathologic