Autoimmune pancreatitis metachronously associated with retroperitoneal fibrosis with IgG4-positive plasma cell infiltration.
Retroperitoneal fibrosis is an uncommon disorder characterized by the formation of a dense plaque of fibrous tissue in the retroperitoneum, and its etiology remains unknown. Autoimmune pancreatitis is a rare type of chronic pancreatitis characterized by fibrosis with abundant infiltration of IgG4-positive plasma cells and lymphocytes and obliterative phlebitis in the pancreas. We present a case of autoimmune pancreatitis that developed 10 mo after the occurrence of retroperitoneal fibrosis. Histological findings of the resected retroperitoneal mass were marked periureteral fibrosis with abundant infiltration of IgG4-positive plasma cells and lymphocytes and obliterative phlebitis. These findings suggest a common pathophysiological mechanism for retroperitoneal fibrosis and autoimmune pancreatitis in this case. Some cases of retroperitoneal fibrosis might be a retroperitoneal lesion of IgG4-related sclerosing disease.
Kamisawa
Terumi
T
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. kamisawa@cick.jp
Chen
Pong-Yui
PY
Tu
Yuyang
Y
Nakajima
Hitoshi
H
Egawa
Naoto
N
D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D002760:Cholangiopancreatography, Endoscopic Retrograde; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D010195:Pancreatitis / Q000276:immunology* / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology; D012185:Retroperitoneal Fibrosis / Q000276:immunology* / Q000473:pathology*
D007074:Immunoglobulin G