title: Enantioselective one-pot three-component synthesis of propargylamines.
abstract: [reaction: see text] A copper(I) complex of i-Pr-pybox-diPh has been found to be an efficient catalyst for an enantioselective one-pot three-component synthesis of propargylamines from aldehydes, amines, and alkynes. The reaction has been applied to a wide variety of aromatic aldehydes with excellent yields (up to 99%) and enantiomeric excesses (up to 99% ee). A transition-state model has been proposed to explain the stereochemical outcome of the reaction.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur, India.
authors.forename: Alakesh
authors.initials: A
authors.lastname: Bisai
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh