title: Intercellular waves propagation in an array of cells coupled through paracrine signaling: a computer simulation study.
abstract: A linear chain of cells is considered in which calcium (Ca2+) fluctuations within a cell are described by a simple minimal model. Cells are coupled together by bidirectional paracrine signaling via calcium oscillations. Two typical zones of propagation are observed: a transition zone and a regular zone. The transition zone exhibits the same phenomena that can be observed in single cells, pairs or triplets of cells. Within the regular zone, simple periodic oscillations of calcium propagate and the Ca2+ signal is similar from one cell to another (same amplitude and same frequency). But, the signals are separated by a slight phase shift characterizing the propagation of Ca2+ waves due to the type of coupling used. We also consider the colonization of the lattice by the abnormal oscillations of sick cells.
authors.affiliation: Laboratory of Nonlinear Modeling and Simulation in Engineering and Biological physics, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde-Cameroon.
authors.forename: W D
authors.initials: WD
authors.lastname: Kepseu
authors.forename: P
authors.initials: P
authors.lastname: Woafo
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology*; D002478:Cells, Cultured; D003198:Computer Simulation; D004058:Diffusion; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism*; D007424:Intracellular Fluid / Q000502:physiology; D007700:Kinetics; D008954:Models, Biological; D019899:Paracrine Communication / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D002118:Calcium