title: Life events exposure before a treated major depressive episode depends on the number of past episodes.
abstract: A cross-sectional survey investigated the relationship between the number of previous depressive episodes and life events, testing the kindling hypothesis, in a sample of 13,377 treated patients with unipolar depression. A linear decline of average life events exposure is observed for more frequent past episodes, even when age, gender and severity are taken into account.
authors.affiliation: Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, INSERM U 669, Paris XI University, 78 rue du General Leclerc, 94230 Le Kremlin Bicêtre, France. emmanuelle.corruble@bct.aphp.fr
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
authors.forename: Bruno
authors.initials: B
authors.lastname: Falissard
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007696:Kindling, Neurologic; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011582:Psychological Theory; D012008:Recurrence; D013315:Stress, Psychological / Q000453:epidemiology / Q000523:psychology; D011795:Surveys and Questionnaires; D013997:Time Factors