Quasispecies theory for multiple-peak fitness landscapes.
We use a path integral representation to solve the Eigen and Crow-Kimura molecular evolution models for the case of multiple fitness peaks with arbitrary fitness and degradation functions. In the general case, we find that the solution to these molecular evolution models can be written as the optimum of a fitness function, with constraints enforced by Lagrange multipliers and with a term accounting for the entropy of the spreading population in sequence space. The results for the Eigen model are applied to consider virus or cancer proliferation under the control of drugs or the immune system.
Saakian
David B
DB
Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Muñoz
E
E
Hu
Chin-Kun
CK
Deem
M W
MW
D005075:Biological Evolution; D003198:Computer Simulation; D017753:Ecosystem; D019143:Evolution, Molecular; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic; D013045:Species Specificity; D016019:Survival Analysis; D015996:Survival Rate