Expression of Notch1 and Hes5 in the developing olfactory epithelium.
CONCLUSIONS
Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE.


METHODS
The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined.


RESULTS
As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.
Orita
Yorihisa
Y
Department of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan. y-orita@cc.okayama-u.ac.jp
Nagatsuka
Hitoshi
H
Tsujigiwa
Hidetsugu
H
Yoshinobu
Junko
J
Maeda
Yukihide
Y
Kakiuchi
Masashi
M
Orita
Saeko
S
Takeuchi
Ayako
A
Takeda
Yasushi
Y
Fukushima
Kunihiro
K
Nagai
Noriyuki
N
Nishizaki
Kazunori
K
D000818:Animals; D000831:Animals, Newborn; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D005865:Gestational Age; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009831:Olfactory Mucosa / Q000254:growth & development* / Q000378:metabolism; D011247:Pregnancy; D051881:Receptor, Notch1 / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
D051792:Basic Helix-Loop-Helix Proteins; D051881:Receptor, Notch1; D012097:Repressor Proteins; C489685:Hes5 protein, mouse; C497762:Notch1 protein, mouse