title: Colonic pseudolipomatosis, microscopically classified into two groups.
abstract: BACKGROUND
  Colonic pseudolipomatosis is rare and the pathogenesis is controversial. The purpose of the present paper was to clarify endoscopic and histological characteristics of colonic pseudolipomatosis and to discuss the etiology.
  
  
  METHODS
  A total of 15 lesions from 14 patients was reviewed. They were able to be histologically classified into two groups on the basis of variety in size of the vacuoles: Group A, the ratio of largest vacuole to smallest vacuole in size is less than three, Group B, the ratio is more than four.
  
  
  RESULTS
  Four of 15 lesions were group A, and were endoscopically polypoid or flat lesions covered with normal-looking mucosa. They were microscopically characterized by (i) predominant location in the upper portion of the lamina propria; (ii) no submucosal involvement; (iii) less variation in vacuolar size; and (iv) no association with lymph follicles. The vacuoles of group A contained proteinaceous materials in two of four lesions. Group B (11 lesions) had small elevated mucosa with normal-looking surface or non-elevated reddish mucosa. Microscopically, the lesions were mainly located in the lower portion of the lamina propria, occasionally also in the submucosa, had variable-sized vacuoles, and were related to lymph follicles.
  
  
  CONCLUSIONS
  It is suggested that the vacuoles in group A contain fluid, and may indicate an abnormal stagnation of interstitial fluid. Microscopic appearance of group B is essentially similar to that of pneumatosis coli. It is thought that group B probably results from penetration of gas from the crypts into the mucosa during colonoscopy. It is unclear why group B had a preference for ileocecal valve and an association with lymph follicles.
authors.affiliation: Department of Pathology, University of Tokushima School of Medicine, Tokushime, Japan. nakasono@clin.med.tokushima-u.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakasono
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hirokawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Muguruma
authors.forename: Seisuke
authors.initials: S
authors.lastname: Okamura
authors.forename: Susumu
authors.initials: S
authors.lastname: Ito
authors.forename: Akiko
authors.initials: A
authors.lastname: Iga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Wada
authors.forename: Michiyo
authors.initials: M
authors.lastname: Okazaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Horie
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Fukuda
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000473:pathology*; D003108:Colonic Diseases / Q000145:classification / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008068:Lipomatosis / Q000145:classification / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011006:Pneumatosis Cystoides Intestinalis / Q000145:classification / Q000473:pathology; D012189:Retrospective Studies; D014617:Vacuoles / Q000473:pathology