title: Interstitial low-dose-rate brachytherapy in the treatment of recurrent head and neck malignancies.
abstract: BACKGROUND
  Recurrent head and neck malignancies are therapeutically challenging. Brachytherapy is a retreatment alternative to external-beam radiation therapy (EBRT).
  
  
  METHODS
  Patients receiving brachytherapy during 1987-2004 for recurrent head and neck cancer were identified. Tumor and treatment characteristics and toxicities were recorded. Progression-free survival (PFS) and overall survival (OS) estimates were generated. The influence of prognostic factors was determined.
  
  
  RESULTS
  Eighty-two patients were analyzable. Analysis was limited to patients who had brachytherapy for a first recurrence (n = 45). Brachytherapy (> or = 55 Gy) was a monotherapy in 22 of 45 patients. As part of their salvage brachytherapy treatments, 14 patients also underwent surgery; 3 patients also underwent EBRT; and 6 patients underwent surgery, EBRT, and brachytherapy. Retreatment morbidity included acute toxicity (n = 7) and late toxicity (n = 18). Median PFS was 15 months, and locoregional control rates at 1 and 2 years were 50% and 37%, respectively. Time to progression differed by site of the primary tumor (p = .10). Median OS was 16 months, and OS at 2 and 5 years was 33% and 11%, respectively.
  
  
  CONCLUSIONS
  Brachytherapy for recurrent head and neck cancer has an acceptable toxicity profile and is viable alternative to EBRT. Further optimization of the best sites and doses for neck brachytherapy is required.
authors.affiliation: Department of Radiation Oncology, Ottawa Hospital Regional Cancer Centre, 503 Smyth Road, Ottawa, Ontario, Canada K1H 1C4. lgrimard@ottawahospital.on.ca
authors.forename: Laval
authors.initials: L
authors.lastname: Grimard
authors.forename: Bernd
authors.initials: B
authors.lastname: Esche
authors.forename: André
authors.initials: A
authors.lastname: Lamothe
authors.forename: Joanna
authors.initials: J
authors.lastname: Cygler
authors.forename: Johanna
authors.initials: J
authors.lastname: Spaans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy*; D011379:Prognosis; D011879:Radiotherapy Dosage; D016879:Salvage Therapy; D015996:Survival Rate; D013997:Time Factors