New strategies of photoprotection.
Adequate photoprotection is essential to control UV-related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming that they are used properly. However, new strategies, which are based on or make use of the endogenous protective response to UV light, may further improve currently used photoprotective means. The addition of repair enzymes and/or antioxidants has a positive effect on skin's recovery from UV-induced DNA-damage. Several botanical agents, mainly vitamins and polyphenols, have shown to influence signal transduction pathways leading to photoprotective effects. Also stimulation of endogenous UV-response pathways via irradiation with a low UV dose or via simulation of UV-induced DNA-damage results in photoprotective effects. Future research in this field and combination of different photoprotective strategies will hopefully lead to improved photoprotection.
Verschooten
Lien
L
Department of Dermatology, Catholic University of Leuven, Belgium.
Claerhout
Sofie
S
Van Laethem
An
A
Agostinis
Patricia
P
Garmyn
Marjan
M
D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D006801:Humans; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D012880:Skin Pigmentation / Q000528:radiation effects*; D013471:Sunburn / Q000517:prevention & control*; D014466:Ultraviolet Rays