title: Expression of basement membrane components in odontogenic cysts.
abstract: OBJECTIVE
  To compare the expression of basement membrane components (BMCs), including laminins 1 and 5, collagen type IV, and fibronectin in odontogenic keratocysts (OKCs) with dentigerous cysts (DCs) and radicular cysts (RCs).
  
  
  METHODS
  Basement membrane components were analysed in 20 OKCs, 20 DCs and 20 RCs using an immunohistochemical technique.
  
  
  RESULTS
  Odontogenic keratocysts, DCs and RCs showed positive reaction to all BMCs studied, with different distributions and intensity. OKCs showed continuous linear deposits for laminins 1 and 5 but two staining patterns (continuous and discontinuous) for collagen type IV and fibronectin. DCs exhibited continuous linear deposits for laminins 1 and 5 and collagen type IV but a discontinuous linear deposit for fibronectin. RCs displayed similar results to DCs for laminin 1, collagen type IV and fibronectin. Laminin 5 in RCs had two staining patterns. Constant results in all cysts were strong intensity for laminin 1 and moderate intensity for laminin 5.
  
  
  CONCLUSIONS
  Substantial differences in the expression of BMCs among studied cysts were not observed, suggesting that the separation of the epithelial lining in OKCs is not associated with the existence of these proteins.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. spoomsawat@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Poomsawat
authors.forename: J
authors.initials: J
authors.lastname: Punyasingh
authors.forename: W
authors.initials: W
authors.lastname: Weerapradist
mesh_terms: D001485:Basement Membrane / Q000737:chemistry* / Q000473:pathology; D024141:Collagen Type IV / Q000096:biosynthesis*; D003238:Connective Tissue / Q000473:pathology; D003803:Dentigerous Cyst / Q000378:metabolism; D004848:Epithelium / Q000473:pathology; D005353:Fibronectins / Q000096:biosynthesis*; D006801:Humans; D007633:Keratins; D007797:Laminin / Q000096:biosynthesis*; D009807:Odontogenic Cysts / Q000378:metabolism*; D011842:Radicular Cyst / Q000378:metabolism
chemical_list: D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin; D007633:Keratins