[Hsp70 chaperone and the prospects of its application in anticancer therapy].
Major stress protein Hsp70 is known to possess two important properties: ATP-dependent activity and protective activity; these two are thought to play a significant role in anticancer therapy. Many malignant tumors contain high amounts of intracellular Hsp70. Moreover, many anticancer drugs themselves are able to elevate Hsp70 expression in tumor cells. Since Hsp70 was found to disturb many signal pathways of apoptosis in many points, the high chaperone expression may lead to an increased resistance of tumor cells to anticancer drugs. On the other hand, when overexpressed by a certain mechanism, Hsp70 is able to emerge at the cell surface by itself or together with tumor antigens and present these to immune cells T-lymphocytes and natural killers, in such a manner that makes cancer cell recognized and abolished. These properties make Hsp70 very promising instrument in designing some novel anticancer vaccines.
Guzhova
I V
IV
Novoselov
S S
SS
Margulis
B A
BA
D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology; D019496:Cancer Vaccines / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D050956:HSP40 Heat-Shock Proteins / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular; D007155:Immunologic Factors / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000276:immunology; D008958:Models, Molecular; D009369:Neoplasms / Q000628:therapy*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000378:metabolism
D000951:Antigens, Neoplasm; C091732:BCL2-associated athanogene 1 protein; D019496:Cancer Vaccines; D004268:DNA-Binding Proteins; C494647:DNAJB1 protein, human; D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D007155:Immunologic Factors; D014157:Transcription Factors