title: The aging gut motility decay: may symbiotics be acting as "implantable" biologic pace-makers?
abstract: Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximal-distal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay.
authors.affiliation: TMC Hospital, Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Metugriachuk
authors.forename: F
authors.initials: F
authors.lastname: Marotta
authors.forename: K
authors.initials: K
authors.lastname: Pavasuthipaisit
authors.forename: O
authors.initials: O
authors.lastname: Kuroi
authors.forename: J
authors.initials: J
authors.lastname: Tsuchiya
authors.forename: A
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: E
authors.initials: E
authors.lastname: Fesce
authors.forename: E
authors.initials: E
authors.lastname: Minelli
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004066:Digestive System Diseases / Q000628:therapy; D004576:Electromyography; D005215:Fasting / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D007421:Intestine, Small / Q000502:physiology; D019936:Probiotics; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
chemical_list: D014660:Vasoactive Intestinal Peptide