An unusual pathologic feature associated with dermatomyositis.
We present a case of juvenile dermatomyositis with unusual histopathologic findings. The child presented with a course consistent with dermatomyositis, a diagnosis confirmed by finding reticulotubular aggregates in endothelial cells on electron microscopy. However, histopathology of his muscle biopsy revealed a striking pattern of glycogen accumulation, to an extent similar to that seen in glycogen storage diseases; this degree of accumulation could potentially confound histopathologic diagnosis.
Sampson
Jacinda B
JB
Department of Neurology, University of Utah, Salt Lake City, UT, USA. jacinda.sampson@hsc.utah.edu
Chin
Steven S
SS
Clayton
Frederic C
FC
Pestronk
Alan
A
Swoboda
Kathryn J
KJ
Flanigan
Kevin M
KM
D001706:Biopsy; D002675:Child, Preschool; D003882:Dermatomyositis / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D004727:Endothelium / Q000473:pathology / Q000648:ultrastructure; D006003:Glycogen / Q000378:metabolism*; D006008:Glycogen Storage Disease / Q000175:diagnosis / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000473:pathology*; D012154:Reticular Formation / Q000473:pathology / Q000648:ultrastructure
D006003:Glycogen