Platelet function in humans is not altered by hyperbaric oxygen therapy.
A pilot survey of platelet function was performed on 6 patients undergoing hyperbaric oxygen therapy (2.0 ATA O2 for 2 hours, 6 days/week) for prophylaxis against osteoradionecrosis. Blood was drawn immediately prior to and after the first, tenth and twentieth treatment for measurements of platelet aggregation, ATP release and expression of activated alphalIb3 integrin. No significant differences were observed due to hyperbaric oxygen exposures.
Thom
S R
SR
Department of Emergency Medicine, University of Pennsylvania Medical Center, 3620 Hamilton Walk, Philadelphia, PA 19104-6068, USA.
Fisher
D
D
Stubbs
J M
JM
D000255:Adenosine Triphosphate / Q000378:metabolism; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000517:prevention & control; D010974:Platelet Aggregation / Q000502:physiology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism
D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000255:Adenosine Triphosphate