Effects of extract of dilong (pheretima) on the scalded skin in rats.
In order to investigate the effects of extract of Dilong (Pheretima) on the skin viability and lipid peroxidation after deep degree II scalds, the extract of Dilong (Pheretima) at two concentrations (5%, 10%) were respectively applied to the surface of wound. The oxygen consumption, the succinate dehydrogenase (SDH) activity, the Schiff's base content, and the healing time of wound surface were determined in Wistar rats at the 8th, 24th, 48th and 72th hour after scalds, with SD-Ag used as controls. The results indicated that the oxygen consumption and SDH activity decreased, and the schiff's base content increased after the scalds. After the application of the extract of Dilong, the oxygen consumption and SDH activity increased, and the schiff's base content decreased significantly as compared with the control group (P < 0.05 or P < 0.01), and the mean healing time of the wound surface was five days in advance in the two treatment groups as compared with the control group. It is suggested that the scalds are related with lipid peroxdation to a certain extent, and the extract of Dilong has actions of attenuating lipid peroxidation, and promoting healing of the wound.
Zhang
Mei
M
The First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Li
Xu
X
Liu
Yi
Y
Ye
Feng
F
Qiu
Genquan
G
D000818:Animals; D002056:Burns / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D009835:Oligochaeta / Q000737:chemistry*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D008419:Materia Medica; D013385:Succinate Dehydrogenase