Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats.
The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
Park
Sung-Woo
SW
Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical Research Institute, Inje University, Busan, Republic of Korea.
Lee
Sun-Kyung
SK
Kim
Jae-Min
JM
Yoon
Jin-Sang
JS
Kim
Young-Hoon
YH
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D019579:Neocortex / Q000187:drug effects*; D000069348:Quetiapine Fumarate; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013312:Stress, Physiological / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D003987:Dibenzothiazepines; D012333:RNA, Messenger; D000069348:Quetiapine Fumarate