Biomimetic approaches to protein and gene delivery for tissue regeneration.
Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwanted and potentially harmful side-effects. Here, we review the natural and synthetic biomaterials that have been developed for protein and gene delivery to enhance tissue regeneration. Particular emphasis is placed on novel biomimetic materials that respond to environmental stimuli or release their cargo according to cellular demand. Engineering biomaterials to release therapeutic agents in response to physiologic signals mimics the natural healing process and can promote faster tissue regeneration and reduce scarring in severe acute or chronic wounds.
Andreadis
Stelios T
ST
Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY 14260, USA. sandread@buffalo.edu
Geer
David J
DJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001698:Biomedical Engineering; D032701:Biomimetics / Q000379:methods*; D004285:Dogs; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006133:Growth Substances / Q000008:administration & dosage; D006801:Humans; D051379:Mice; D011506:Proteins / Q000008:administration & dosage; D011817:Rabbits; D051381:Rats; D012038:Regeneration; D014945:Wound Healing / Q000502:physiology*
D001672:Biocompatible Materials; D006133:Growth Substances; D011506:Proteins