Dissociation of biological catch-bond by periodic perturbation.
The analysis of the P-selectin/PSGL-1 catch-slip bond that is periodically driven by a detaching force predicts that in the frequency range on the order of 1 s(-1) the bond lifetime undergoes significant changes with respect to both frequency and amplitude of the force. The result indicates how variations in the heart rate could have a substantial effect on leukocyte and lymphoid cell transport and adhesion to endothelial cells and platelets during inflammatory processes.
Pereverzev
Yuriy V
YV
Prezhdo
Oleg V
OV
D000818:Animals; D006801:Humans; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008962:Models, Theoretical; D019007:P-Selectin / Q000378:metabolism*; D011485:Protein Binding; D033081:Shear Strength
D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein