Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles.
In skeletal muscles and heart in vitro complex IV activity is lower in young adult caloric restricted (CR) animals despite normal aerobic function in situ and in vivo. On the other hand, whereas markers of oxidative capacity decline 25% to 46% between 8 and 10 months and 35 months in ad libitum fed (AL) animals, in most muscles there is no decline in CR across the same absolute age (35 mo old) or relative age (35% survival rate) span and PGC-1alpha gene expression in gastrocnemius muscle declines more slowly with aging. The present results show that CR largely prevents the age-associated decline in mitochondrial function in heart and skeletal muscles, and suggest that this is secondary to a better-maintained drive on mitochondrial biogenesis.
Hepple
Russell T
RT
Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. hepple@ucalgary.ca
Baker
David J
DJ
McConkey
Marina
M
Murynka
Tania
T
Norris
Robin
R
D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D002950:Citrate (si)-Synthase / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D051381:Rats; D011916:Rats, Inbred F344; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors; D002950:Citrate (si)-Synthase