title: A mathematical model of Saccharomyces cerevisiae growth in response to cadmium toxicity.
abstract: Microbial growth can be described using models derived by differential equations, but available mathematical models have yet to adequately describe lag phase related cell growth or cell mortality in response to chemical toxicity. Lag phase cell behavior, however, dictates the onset of exponential growth and the number of actively growing cells available to initiate exponential growth, important factors in the success of remediation efforts. In this study, a five-parameter polynomial ratio (PR) model was used to characterize the growth, from lag through stationary phase, of the yeast Saccharomyces cerevisiae in response to cadmium toxicity. The PR model used in this study has the advantages over standard mathematical models in the ability to represent the initial cell mortality observed when S. cerevisiae is exposed to increasing cadmium levels, up to 12 mg/l Cd, as well as following cell recovery and growth to stationary levels.
authors.affiliation: University of Colorado at Denver and Health Sciences Center, Department of Biology, Campus Box 171, P.O. Box 173364, CO 80217-3364, USA.
authors.forename: Katie A
authors.initials: KA
authors.lastname: Hietala
authors.forename: Miranda L
authors.initials: ML
authors.lastname: Lynch
authors.forename: John C
authors.initials: JC
authors.lastname: Allshouse
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Johns
authors.forename: Timberley M
authors.initials: TM
authors.lastname: Roane
mesh_terms: D002104:Cadmium; D003470:Culture Media; D008433:Mathematics; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000254:growth & development*
chemical_list: D003470:Culture Media; D002104:Cadmium