title: A simple formula for individualising ceftazidime dosage administered by continuous infusion in patients with haematological malignancies.
abstract: A formula is proposed for individualising ceftazidime dosage administered by continuous infusion in patients with haematological malignancies. Sixty patients were retrospectively randomised into Group A (n=30) to establish the formula and Group B (n=30) to evaluate this formula. Individual ceftazidime clearances were estimated from the ratio between the rate of infusion and plasma concentration at steady state. In Group A, ceftazidime clearance was significantly correlated with creatinine clearance. From this result, a formula (rate of infusion (g/day)=0.00133x[creatinine clearance (mL/min)]x[target concentration at steady state (mg/L)]) is proposed. This formula provided consistent estimations of ceftazidime plasma concentrations in Group B and should help clinicians to define the optimum ceftazidime dosage, particularly in patients with disturbed renal function.
authors.affiliation: Laboratoire de Pharmacologie Clinique, Hôtel Dieu, 9 Quai Moncousu, 44093 Nantes Cedex, France. eric.dailly@chu-nantes.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Dailly
authors.forename: Anne
authors.initials: A
authors.lastname: Brun
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Kergueris
authors.forename: Caroline
authors.initials: C
authors.lastname: Victorri-Vignoli
authors.forename: Noël
authors.initials: N
authors.lastname: Milpied
authors.forename: Pascale
authors.initials: P
authors.lastname: Jolliet
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002442:Ceftazidime / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005334:Fever / Q000188:drug therapy; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009503:Neutropenia / Q000188:drug therapy; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime