Aging and innate immunity.
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also has a profound impact on innate immunity, which in turn markedly impacts the health and longevity of older people.
Solana
Rafael
R
Department of Cellular Biology, Physiology, and Immunology, University of Córdoba, E-14004 Córdoba, Spain. rsolana@uco.es
Pawelec
Graham
G
Tarazona
Raquel
R
D000375:Aging / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D015398:Signal Transduction / Q000276:immunology*