title: Influence of phenol, p-cresol and indole on growth and survival of intestinal lactic acid bacteria.
abstract: Some intestinal bacteria can produce many genotoxic, mutagenic and carcinogenic substances. The major products of the bacterial aromatic amino acids fermentation-phenolic and indolic compounds which are responsible for colon cancer development are accumulated in the colon. The effect of phenol, p-cresol and indole (2, 20 and 100 microg/ml doses) on growth and survival of four strains of intestinal lactic acid bacteria was studied. Growth of bacteria was not affected by any of the concentrations of phenol and p-cresol tested. The growth of 2 strains was slightly inhibited by 100 microg/ml of indole. There was no influence of phenol and p-cresol on survival of lactic bacteria until 120 h and specific reaction to carcinogens depending on strain was observed after that incubation time. Indole concentrations 20 and 100 microg/ml appeared to be toxic for all tested strains but just after 24, 48 or 72 h of incubation depending on the strain. In total, 2 microg/ml of indole had a very little effect.
authors.affiliation: Department of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Technical University of Lodz, ul. Wolczanska 171/173, 90-924 Lodz, Poland. adriana_nowak13@wp.pl
authors.forename: Adriana
authors.initials: A
authors.lastname: Nowak
authors.forename: Zdzislawa
authors.initials: Z
authors.lastname: Libudzisz
mesh_terms: D002273:Carcinogens / Q000494:pharmacology*; D003408:Cresols / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007422:Intestines / Q000382:microbiology; D007780:Lacticaseibacillus casei / Q000187:drug effects* / Q000254:growth & development; D048191:Lactiplantibacillus plantarum / Q000187:drug effects* / Q000254:growth & development; D019800:Phenol / Q000494:pharmacology*; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D002273:Carcinogens; D003408:Cresols; D007211:Indoles; C032538:4-cresol; D019800:Phenol; C030374:indole