title: Overgrowth with severe developmental delay following IVF/ICSI: A newly recognized syndrome?
abstract: We report on a child with postnatal overgrowth, noted from 3 months of age, associated with severe developmental delay and refractory seizures. The patient was conceived using in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). The patient's features do not resemble any reported overgrowth syndromes reported so far. We propose that this is a previously unrecognized disorder. The potential role of ICSI/IVF in the pathogenesis of this condition is unknown. No imprinting defect at chromosome 11p15 was identified.
authors.affiliation: Mount Sinai Hospital, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Prakesh S
authors.initials: PS
authors.lastname: Shah
authors.forename: Rosanna
authors.initials: R
authors.lastname: Weksberg
authors.forename: David
authors.initials: D
authors.lastname: Chitayat
mesh_terms: D002648:Child; D002658:Developmental Disabilities / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D012720:Severity of Illness Index; D020554:Sperm Injections, Intracytoplasmic; D013577:Syndrome