The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy.
The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is involved in numerous nuclear functions including maintaining nuclear shape, determining nuclear positioning, organizing chromatin and regulating the cell cycle, DNA replication, transcription, cell differentiation, apoptosis, and aging. Alterations in the composition of nuclear lamins and their associated proteins are currently emerging as an additional event involved in malignant transformation, tumor propagation and progression, thus identifying potential novel targets for future anti-cancer therapy. Here, we review the current knowledge on lamin expression patterns in cells of hematologic malignancies and give an overview on the roles of the nuclear lamina proteins in heterochromatin organization, apoptosis, and aging with special emphasis on the relevance in cancer development.
Prokocimer
Miron
M
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Margalit
Ayelet
A
Gruenbaum
Yosef
Y
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D034882:Lamins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D034881:Nuclear Lamina / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D002843:Chromatin; D034882:Lamins