title: Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer: A cross-sectional study.
abstract: OBJECTIVE
  To investigate the correlation of depressed-type (0-IIc) colorectal neoplasm and family history of first-degree relatives (FDR) with colorectal cancer (CRC).
  
  
  METHODS
  This cross-sectional study was conducted from June 2000 to October 2002 at National Cancer Center Hospital East. Eligible patients undergoing initial total colonoscopy were surveyed regarding family history of CRC among FDR by a questionnaire prior to colonoscopic examinations. All endoscopic findings during colonoscopy were recorded and the macroscopic classification of the early stage neoplasm/cancer was classified into two types (0-IIc vs non 0-IIc). Odds ratios (OR) and 95% confidence intervals (CI) were calculated by univariate and multivariate logistic regression to estimate the association between macroscopic features and clinicopathological data including gender, age, and family history of FDR with CRC.
  
  
  RESULTS
  The OR of an association between family history of FDR with CRC and overall early stage neoplasm adjusted by gender and age was 1.85 (95% CI: 1.31-2.61, P = 0.0004), that for non 0-IIc neoplasm was 1.71 (95% CI: 1.22-2.41, P = 0.0017) and for 0-IIc colorectal neoplasm was 2.78 (95% CI: 1.49-5.16, P = 0.0031).
  
  
  CONCLUSIONS
  Our study shows a significant association between a family history of FDR with CRC and 0-IIc colorectal neoplasm. When patients with a family history of FDR with CRC undergo colonoscopy, colonoscopists should check carefully for not only polypoid, but also depressed-type (0-IIc) lesions.
authors.affiliation: Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa-city, Chiba 277-8577, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Iwasaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sano
authors.forename: Kuang-I
authors.initials: KI
authors.lastname: Fu
authors.forename: Ai
authors.initials: A
authors.lastname: Machida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okuno
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kuwamura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yoshino
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Mera
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Kato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtsu
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yoshida
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016017:Odds Ratio; D010375:Pedigree