Aquaporin-5 water channel in lipid rafts of rat parotid glands.
Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion. The activation of M3 muscarinic acetylcholine receptors (mAChRs) or alpha1-adrenoceptors on the salivary glands induces salivary fluid secretion. AQP5 localizes in lipid rafts and activation of the M3 mAChRs or alpha1-adrenoceptors induced its translocation together with the lipid rafts to the APM in the interlobular ducts of rat parotid glands. This review focuses on the mechanisms of AQP5 translocation together with lipid rafts to the APM in the interlobular duct cells of parotid glands of normal rats and the impairment of AQP5 translocation in diabetes and senescence.
Ishikawa
Yasuko
Y
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan. ishikawa@dent.tokushima-u.ac.jp
Cho
Gota
G
Yuan
Zhenfang
Z
Inoue
Noriko
N
Nakae
Yoshiko
Y
D058646:Adrenergic alpha-1 Receptor Agonists; D000375:Aging / Q000378:metabolism; D000818:Animals; D027321:Anion Transport Proteins / Q000378:metabolism; D051402:Aquaporin 5 / Q000378:metabolism*; D001693:Biological Transport, Active; D018118:Chloride Channels / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D010306:Parotid Gland / Q000378:metabolism*; D021381:Protein Transport; D051381:Rats; D043587:Receptor, Muscarinic M3 / Q000819:agonists; D014882:Water-Electrolyte Balance; D014987:Xerostomia / Q000503:physiopathology
D058646:Adrenergic alpha-1 Receptor Agonists; D027321:Anion Transport Proteins; C496040:Aqp5 protein, rat; D051402:Aquaporin 5; D018118:Chloride Channels; C486572:Clcnkb protein, rat; D008565:Membrane Proteins; D043587:Receptor, Muscarinic M3