title: Infiltrating orbital astrocytic proliferation associated with congenitally malformed eyes.
abstract: This report describes the clinical and pathologic findings in two adults with orbital infiltration by astrocytic cells associated with congenitally malformed eyes. Both cases had enlarging orbital masses and underwent complete resection. Histopathology revealed proliferation of astrocytes (fibrillary acidic protein-positive) that invaded the orbital tissues. To the best of our knowledge, there are no similar cases in the literature.
authors.affiliation: Department of Ophthalmology, West Virginia University Eye Institute, Morgantown, 26506, USA. jsivak@hsc.wvu.edu
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Sivak-Callcott
authors.forename: John V
authors.initials: JV
authors.lastname: Linberg
authors.forename: Jack
authors.initials: J
authors.lastname: Rootman
authors.forename: Valerie A
authors.initials: VA
authors.lastname: White
authors.forename: Scott
authors.initials: S
authors.lastname: Nestor
authors.forename: H James
authors.initials: HJ
authors.lastname: Williams
mesh_terms: D000328:Adult; D000368:Aged; D000853:Anophthalmos / Q000473:pathology*; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008850:Microphthalmos / Q000473:pathology*; D009801:Oculomotor Muscles / Q000473:pathology; D009916:Orbital Diseases / Q000175:diagnosis* / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins