Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice.
Chronic hypercortisolemia is a hallmark of neuroendocrine and psychiatric disorders, such as Cushing's disease and depression. Whether cortisol directly contributes to the altered mood and anxiety symptoms seen in these diseases remains unclear. To address this, the authors have modeled hypercortisolemia by administering corticosterone in the drinking water of female Swiss Webster mice for 17 or 18 days (13 mg/kg). Light-dark emergence, startle habituation, and startle reactivity were measured. Chronic but not acute treatment with corticosterone increased the latency to emerge into the light compartment, an anxiogenic-like effect. Chronic corticosterone treatment did not affect startle habituation, but did reduce startle reactivity. This study suggests that chronic hypercortisolemia may contribute to anxiety-related behavior in patients with Cushing's disease and depression.
Ardayfio
Paul
P
Laboratory of Molecular Neurobiology, Mclean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Kim
Kwang-Soo
KS
D000308:Adrenocortical Hyperfunction / Q000139:chemically induced* / Q000150:complications*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000209:etiology*; D001522:Behavior, Animal / Q000187:drug effects; D003345:Corticosterone / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D051379:Mice; D011930:Reaction Time / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology; D018709:Statistics, Nonparametric; D013647:Task Performance and Analysis
D000893:Anti-Inflammatory Agents; D003345:Corticosterone