[The modulatory influence of moxonidine on the different link of sympatho-adrenal system and hemodynamic reactions in normo and hypertensive rats during emotional stress].
Effect of moxonidine on hemodynamic parameters, baroreflex sensitivity (BS) and sympatho-adrenal system was studied on the model of emotional stress in normotensive (N) and hypertensive (H) rats. Moxonidine was administered intravenously in daily dose 100 mcg/kg during one week prior to stress condition. It was shown that moxonidine reduced pressor reactions of arterial pressure, tachycardia and have increased BS especially in H animals, which was blunted during aversive stimulation. Moxonidine also revealed the effect of pharmacological correction of catecholamine - norepinephrine and epinephrine content in the myocardium and adrenals in stress and post stress period more markedly in H rats. The data obtained indicate the preventive antistress activity of the moxonidine.
Bakuridze
K A
KA
Gongadze
N V
NV
D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D013315:Stress, Psychological / Q000523:psychology*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology* / Q000627:therapeutic use*
D007093:Imidazoles; D013565:Sympatholytics; C043482:moxonidine