title: Penetrating keratoplasty: outcomes from a corneal unit compared to national data.
abstract: OBJECTIVE
  To determine long term graft survival rates and visual results for different indications for penetrating keratoplasty from a single institution over 10 years and compare these to national outcome data.
  
  
  METHODS
  Retrospective chart analysis. 784 records were available for review of 1096 consecutive penetrating keratoplasty procedures performed between 1990 and 1999 (72%). Outcomes of graft survival, visual acuity, and astigmatism were analysed and compared to national outcome data supplied by the UK Transplant Service.
  
  
  RESULTS
  At 5 year follow up, overall graft survival was 66%. This was subdivided into 98% for keratoconus, 86% for viral keratitis, 85% for Fuchs' dystrophy, 84% for pseudophakic bullous keratopathy, 55% for regrafts, and 57% for other diagnoses. There was a significantly higher graft survival rate for all diagnostic subgroups except Fuchs' dystrophy at 3 years of follow up compared to the national average. Best corrected visual acuity at 5 years was 6/18 or better in 53% of cases. The mean keratometric astigmatism was 3.4 dioptres.
  
  
  CONCLUSIONS
  Penetrating keratoplasty is a safe and effective treatment for selected corneal disorders. Penetrating keratoplasty for viral keratitis may achieve good results with long term antiviral treatment. Patients may achieve better outcomes if their surgery is performed at specialist centres.
authors.affiliation: Corneoplastic Unit and Eye Bank, Queen Victoria Hospital NHS Foundation Trust, Holtye Road, East Grinstead, West Sussex, RH19 3DZ, UK.
authors.forename: P
authors.initials: P
authors.lastname: Beckingsale
authors.forename: I
authors.initials: I
authors.lastname: Mavrikakis
authors.forename: N
authors.initials: N
authors.lastname: Al-Yousuf
authors.forename: E
authors.initials: E
authors.lastname: Mavrikakis
authors.forename: S M
authors.initials: SM
authors.lastname: Daya
mesh_terms: D000328:Adult; D000368:Aged; D001251:Astigmatism / Q000209:etiology; D003316:Corneal Diseases / Q000601:surgery*; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D016849:Keratitis, Herpetic / Q000601:surgery; D007640:Keratoconus / Q000601:surgery; D015948:Keratoplasty, Penetrating / Q000592:standards; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014792:Visual Acuity