title: Idiopathic pure red cell aplasia: case report with review of literature.
abstract: Pure red cell aplasia (PRCA) is characterized by near absence of red blood cell precursors in the bone marrow with associated anemia and reticulocytopenia. Megakaryocytes and white blood cell precursors remain intact. Acute self-limited PRCA is the most common form. Acquired chronic PRCA is often idiopathic but can be associated with underlying disorders such as thymoma or autoimmune diseases. Congenital PRCA is associated with physical abnormalities. Pure red blood cell aplasia should always be included in the differential diagnosis of chronic unexplained anemia. We report a case of idiopathic pure red blood cell aplasia in an elderly male who has had a chronic anemia with recurrent blood transfusions for about 30 years.
authors.affiliation: U.S.D. School of Medicine, Internal Medicine Residency Program, Sioux Falls, SD, USA. wkhalife@yahoo.com
authors.forename: Wissam
authors.initials: W
authors.lastname: Khalife
authors.forename: Eric
authors.initials: E
authors.lastname: Murunga
authors.forename: Fade
authors.initials: F
authors.lastname: Mahmoud
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000368:Aged; D000740:Anemia / Q000209:etiology; D001562:Benzimidazoles / Q000009:adverse effects; D004791:Enzyme Inhibitors / Q000009:adverse effects; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000009:adverse effects / Q000031:analogs & derivatives; D064750:Rabeprazole; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D020280:Sertraline / Q000009:adverse effects
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D009853:Omeprazole; D064750:Rabeprazole; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline