[Influence of some low doses of ionizing radiation on the transmembrane transport of sodium, potassium and calcium ions in normal and tumor cells in experiment].
Problem of treatment of various malignant tumors is one of the most acute ones in contemporary medicine. In evaluation of treatment efficiency it is important to implement the sensitive tests, which allow precise determination of treatment agent, specifically that of ionizing irradiation. One of such sensitive indices is the rate of transmembrane transport of Na(+), K(+), and Ca(2+), as well as enzymes controlling this transport. In the present work characteristics of transport of these ions and enzymes were assessed during low dose (0,05 and 0,1 Gy) irradiation, which attracts increased attention nowadays. Recording of the ions' concentration was performed with the ion-selective electrodes. The cells of Erlich carcinoma were studied. It was found that irradiation with doses of 0,05 and 0,1 Gy, unlike dose of 0,5 Gy, exerted a stimulating effect on the ion transport. The same is true in regard of enzymes, which control transport of ions, especially those involved in Ca(2+) transport. The mechanism of this effect is unclear as yet.
Nadareĭshvili
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D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D011188:Potassium / Q000378:metabolism*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D012964:Sodium / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D012964:Sodium; D011188:Potassium; D002118:Calcium