title: Caulerpenyne-colchicine hybrid: synthesis and biological evaluation.
abstract: The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.
authors.affiliation: UMR-CNRS 6178 SymBio, équipe Synthèse par voie Organométallique, Université Paul Cézanne (Aix-Marseille III), Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Bourdron
authors.forename: Laurent
authors.initials: L
authors.lastname: Commeiras
authors.forename: Pascale
authors.initials: P
authors.lastname: Barbier
authors.forename: Véronique
authors.initials: V
authors.lastname: Bourgarel-Rey
authors.forename: Eddy
authors.initials: E
authors.lastname: Pasquier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vanthuyne
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Hubaud
authors.forename: Vincent
authors.initials: V
authors.lastname: Peyrot
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Parrain
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003078:Colchicine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D011108:Polymers / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D012717:Sesquiterpenes; D014404:Tubulin; C097889:caulerpenyne; D003078:Colchicine