Esthesioneuroblastoma recurrence presenting as a syndrome of inappropriate antidiuretic hormone secretion.
BACKGROUND
Esthesioneuroblastoma is an uncommon intranasal tumor. These neuroendocrine neoplasms are rarely associated with excess hormone syndromes, and only nine cases of inappropriate antidiuretic hormone syndrome (SIADH) secondary to an esthesioneuroblastoma have been described. In all these cases, electrolyte abnormalities were seen when the tumor initially developed. We report a unique case of esthesioneuroblastoma recurrence manifesting as SIADH as the solely presenting feature.


RESULTS
A 34-year-old woman was referred to us for evaluation for hyponatremia. She had undergone resection of an esthesioneuroblastoma at age 18 with radiotherapy. The patient had undergone annual CT of the nasal area and was considered to be disease free. The study of the hyponatremia was consistent with a SIADH, and MRI revealed an intranasal mass. The resection of the tumor reversed the hyponatremia, and pathologic analysis revealed a recurrence of esthesioneuroblastoma.


CONCLUSIONS
Biochemical analysis should be performed in the follow-up of patients with esthesioneuroblastoma. In our case, the biochemical abnormality led to the diagnosis of the recurrence.
Plasencia
Y López
YL
Endocrinology Department, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria University, Avda. Marítima del Sur s/n, 35016. Las Palmas de Gran Canaria, Spain. yloppla@yahoo.com
Cortés
M Boronat
MB
Arencibia
D Marrero
DM
Dámaso
T Montenegro
TM
Contreras
I Lisner
IL
Pino
A Ojeda
AO
Domínguez
A Carrillo
AC
Brier
F La Roche
FL
Delgado
Y García
YG
Mogollón
F J Nóvoa
FJ
D000328:Adult; D018304:Esthesioneuroblastoma, Olfactory / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D009296:Nasal Cavity; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D009669:Nose Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy