title: Red hot chili pepper and hemorrhoids: the explosion of a myth: results of a prospective, randomized, placebo-controlled, crossover trial.
abstract: OBJECTIVE
  Spicy foods are appreciated by a large part of the world population but have been blamed for causing hemorrhoids or exacerbating their symptoms, although no epidemiologic studies have been performed supporting this hypothesis. In this double-blind, randomized, placebo-controlled, crossover trial, we have studied the effects of a single dose of red hot chili pepper on the hemorrhoidal symptoms.
  
  
  METHODS
  Fifty patients with second-degree and third-degree symptomatic hemorrhoids were randomly assigned to take a capsule containing red hot chili powder or placebo during lunch, scoring five hemorrhoidal symptoms (bleeding, swelling, pain, itching, and burning) on a visual analog scale. After one week, crossover treatment was administered according to the same methodology. Other treatments and foods potentially related with anorectal symptoms were discontinued during the study periods.
  
  
  RESULTS
  Patients assigned low scores to their hemorrhoidal symptoms before the study and the scores remained unchanged during the 48 hours after both placebo and chili pepper treatment, the latter showing no statistically significant effects.
  
  
  CONCLUSIONS
  There is no scientific evidence that a spicy meal based on red hot chili pepper may worsen hemorrhoidal symptoms and, therefore, there is no reason to prevent these patients from occasionally enjoying a spicy dish if they so wish.
authors.affiliation: Department of Emergency and Organ Transplantation, General Surgery and Liver Transplantation Units, University of Bari, Bari, Italy. altomare@clichiru.uniba.it
authors.forename: Donato F
authors.initials: DF
authors.lastname: Altomare
authors.forename: Marcella
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Filippo
authors.initials: F
authors.lastname: La Torre
authors.forename: Donato
authors.initials: D
authors.lastname: Scardigno
authors.forename: Antonietta
authors.initials: A
authors.lastname: Roveran
authors.forename: Stefano
authors.initials: S
authors.lastname: Canuti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morea
authors.forename: Liana
authors.initials: L
authors.lastname: Spazzafumo
mesh_terms: D000328:Adult; D002212:Capsicum / Q000009:adverse effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006484:Hemorrhoids / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D015990:Placebo Effect; D028321:Plant Preparations / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies
chemical_list: D028321:Plant Preparations