title: Origins of the T(H)1-T(H)2 model: a personal perspective.
abstract: Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis.
authors.affiliation: Dynavax Technologies, Berkeley, California 94710, USA. rcoffman@dvax.com
authors.forename: Robert L
authors.initials: RL
authors.lastname: Coffman
mesh_terms: D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*