Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin.
The neutral mononuclear copper(II) complex with the quinolone antibacterial drug sparfloxacin has been prepared and characterized with IR, UV-vis, and EPR spectroscopies and X-ray crystallography. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms.
Efthimiadou
Eleni K
EK
Institute of Physical Chemistry, NCSR Demokritos, 15310 Aghia Paraskevi Attikis, Greece.
Sanakis
Yiannis
Y
Raptopoulou
Catherine P
CP
Karaliota
Alexandra
A
Katsaros
Nikos
N
Psomas
George
G
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000032:analysis / Q000378:metabolism; D024841:Fluoroquinolones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013053:Spectrophotometry
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009942:Organometallic Compounds; D015363:Quinolones; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C061363:sparfloxacin