SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes.
Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG-3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2 = 0.68, P < 0.05) but also in type 2 patients (R2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes.
Yamada
Yuichiro
Y
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606 8507, Japan. yamada@metab.kuhp.kyoto-u.ac.jp
Fukuda
Kazuhito
K
Fujimoto
Shimpei
S
Hosokawa
Masaya
M
Tsukiyama
Katsushi
K
Nagashima
Kazuaki
K
Fukushima
Mitsuo
M
Suzuki
Haruhiko
H
Toyoda
Kentaro
K
Sassa
Mariko
M
Funakoshi
Shogo
S
Inagaki
Nobuya
N
Taniguchi
Ataru
A
Sato
T Shun
TS
Matsumoto
Shinichi
S
Tanaka
Koichi
K
Seino
Yutaka
Y
D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000378:metabolism*; D016381:Islets of Langerhans Transplantation
D001786:Blood Glucose; D007328:Insulin