title: Application of I(125) brachytherapy combined artificial joint prosthesis in malignant osteo- and soft-tissue sarcoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate the brachytherapy effectiveness of I(125) seeds combined with artificial prosthesis in malignant sarcoma therapy.
  
  
  METHODS
  The combination of I(125) seeds and artificial prosthesis was implanted to replace tumor section for three clinical cases-2 malignant osteosarcoma patients and 1 malignant soft-tissue tumor patient- through the direct operation.
  
  
  RESULTS
  Approximately 14-18 months after the operation, the results of our post-operational investigation showed that the tumor tissues of 3 patients had been completely removed. The limb functions recovered well. The brachytherapy of the combination of I(125) seeds and artificial prosthesis in malignant tumor improved the curative effect. No tumor existed, and no infection occurred.
  
  
  CONCLUSIONS
  It was demonstrated that this method was safe and easy. No side-effect was observed after the implantation of I(125) seeds. The brachytherapy was proven to be a potential method for patients who were at high risk to recrudesce the malignant osteosarcoma of tumors after the tumor excision.
authors.affiliation: Department of Bone Tumor, Academy of Military Medical Sciences, Beijing, China.
authors.forename: D F
authors.initials: DF
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Cui
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Su
authors.forename: W J
authors.initials: WJ
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: J H
authors.initials: JH
authors.lastname: Sui
authors.forename: Yanjun J
authors.initials: YJ
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000532:radiotherapy* / Q000601:surgery; D012509:Sarcoma / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D007457:Iodine Radioisotopes