title: Investigation of the possible association between nosocomial candiduria and candidaemia.
abstract: This study aimed to determine whether candiduria is associated with the occurrence of nosocomial candidaemia. In the case-control part of the study, 115 cases (nosocomial candidaemia) and 115 controls (nosocomial bacteraemia) were similar in age, severity of condition and time of hospitalisation. There was a significant association of candidaemia with candiduria (OR 9.79; 95% CI 2.14-44.76). In the microbiology part of the study, 23 pairs of Candida-positive urine and blood cultures were obtained from 23 patients. In ten (43%) cases, the urine and blood culture isolates belonged to different species, and molecular typing showed a difference in two of the 13 cases yielding the same species from both specimens. Overall, there was a significant association between candiduria and candidaemia, but the Candida isolates from urine and blood were different for 52% of the patients. Thus, the data indicated that the urinary tract was probably not a source for the candidaemia.
authors.affiliation: Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Binelli
authors.forename: M L
authors.initials: ML
authors.lastname: Moretti
authors.forename: R S
authors.initials: RS
authors.lastname: Assis
authors.forename: N
authors.initials: N
authors.lastname: Sauaia
authors.forename: P R
authors.initials: PR
authors.lastname: Menezes
authors.forename: E
authors.initials: E
authors.lastname: Ribeiro
authors.forename: D C P
authors.initials: DC
authors.lastname: Geiger
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: M
authors.initials: M
authors.lastname: Miyaji
authors.forename: M S
authors.initials: MS
authors.lastname: Oliveira
authors.forename: A A
authors.initials: AA
authors.lastname: Barone
authors.forename: A S
authors.initials: AS
authors.lastname: Levin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D017931:DNA Primers / Q000737:chemistry; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D017931:DNA Primers