[Studies on antiviral constituents in stems and leaves of Pithecellibium clypearia].
OBJECTIVE
To study the antiviral constituents in the stems and leaves of Pithecellibium clypearia.


METHODS
The constituents of P. clypearia were systematically separated with various chromatographic techniques in combination with antiviral activity monitoring. Their structures were elucidated by physical and chemical properties and spectral data.


RESULTS
Six compounds were isolated from P. clypearia and were identified as: tricetiflavan (5, 7, 3', 4', 5'-pentahydroxylflavan) (1), myricitrin (myricetin-3-O-alpha-L-rhamnopyranoside) (2), quercitrin (quercetin-3-O-alpha-L-rhamnopyranoside) (3), quereetin (4), methyl gallate (5) and gallic acid (6).


CONCLUSIONS
Compound 1 approximately 5 were obtained from this plant for the first time. Compound 4 was found to show an obvious anti-respiratory syncytial virus (RSV) activity.
Li
Yao-lan
YL
Chemistry Department, Life Science and Technology Institute, Jinan University, Guangzhou, China.
Li
Ke-ming
KM
Su
Miao-xian
MX
Leung
Kan-tong
KT
Chen
Yu-wu
YW
Zhang
Yong-wen
YW
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects
D000998:Antiviral Agents; D005419:Flavonoids; C008577:myricitrin; C052082:methyl gallate; D005707:Gallic Acid; D011794:Quercetin