Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus.
Myelopeptide-2 (MP-2; Leu-Val-Val-Tyr-Pro-Trp), originally isolated from the supernatant of porcine bone marrow cell culture, is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from HL-60 leukemia cells or measles virus. This effect is based on the ability of MP-2 to recover the reduced interleukin (IL)-2 synthesis and IL-2 receptor (IL-2R) expression in human T lymphocytes treated with these harmful agents. The involvement of other cytokines in MP-2 restoration of the reduced IL-2 synthesis in T lymphocytes is experimentally studied. It is shown that T helper (TH) 1 and TH2 cytokines are acting in close interaction, the character of which depends on the immune status of the T-lymphocyte donors. The data obtained allow one to suggest that the MP-2 involvement in regulatory processes is directed to the maintenance of immune homeostasis. This peptide is perspective to be applied in antitumor and antivirus therapy.
Mikhailova
Augusta A
AA
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Belevskaya
Raissa G
RG
Kalyuzhnaya
Maria
M
Fonina
Larissa A
LA
Liashenko
Vsevolod A
VA
Petrov
Rem V
RV
D000951:Antigens, Neoplasm / Q000378:metabolism; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D007107:Immune System / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism*; D008213:Lymphocyte Activation; D008459:Measles virus / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D009842:Oligopeptides / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D000951:Antigens, Neoplasm; D016207:Cytokines; D007376:Interleukin-2; D009842:Oligopeptides; D015375:Receptors, Interleukin-2; C048617:myelopeptides; D007371:Interferon-gamma