title: Neurotoxicity evaluation of the organofluorine pesticide etoxazole in the brain of Oreochromis niloticus.
abstract: Etoxazole is a new organofluorine pesticide that has been used worldwide as acaricide and insecticide since 1998. Almost no previous attempt has been made to evaluate the toxic effects of etoxazole in vertebrates. Using fish (Oreochromis niloticus) as a suitable model organism, the aim of this study was to indicate whether etoxazole affects acetylcholinesterase and sodium potassium-activated adenosine triphosphatase activities in the brain tissue in order to evaluate the impacts on neurotoxicity and ion transportation. Enzyme activities were determined using spectrophotometric methods. At the sublethal concentrations (0.27, 0.54, 0.81, 1.08, 1.35 mg/L) and exposure durations (1, 7, 15 days) tested, etoxazole has no inhibitory effect on the brain acetylcholinesterase and sodium potassium-activated adenosine triphosphatase activities. Our results suggest that etoxazole and/or its metabolites may not reach or penetrate the blood-brain barrier; therefore, they do not essentially alter the functions of these two important enzymes for the brain.
authors.affiliation: Department of Biology, University of Cukurova, Faculty of Science and Letters, Balcali, Adana, Turkey. nuner@cu.edu.tr
authors.forename: Nevin
authors.initials: N
authors.lastname: Uner
authors.forename: Elif
authors.initials: E
authors.lastname: Oruç
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sevgiler
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000145:classification / Q000633:toxicity; D023681:Cichlids; D004305:Dose-Response Relationship, Drug; D010080:Oxazoles / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D018675:Toxicity Tests
chemical_list: D002800:Cholinesterase Inhibitors; D010080:Oxazoles; D010575:Pesticides; D000110:Acetylcholinesterase; D000254:Sodium-Potassium-Exchanging ATPase; C508136:etoxazole