Histone H4 lysine 16 acetylation breaks the genome's silence.
Acetylation at histone H4 lysine 16 is involved in many cellular processes in organisms as diverse as yeast and humans. A recent biochemical study pinpoints this particular acetylation mark as a switch for changing chromatin from a repressive to a transcriptionally active state.
Shia
Wei-Jong
WJ
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
Pattenden
Samantha G
SG
Workman
Jerry L
JL
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D004330:Drosophila / Q000235:genetics; D005260:Female; D016678:Genome; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008297:Male; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015533:Transcriptional Activation
D002843:Chromatin; D006657:Histones; D008239:Lysine