title: Bilateral osteonecrosis of the head of the femur during treatment with retinoic acid in a young patient with acute promyelocytic leukemia.
abstract: All-trans retinoic acid (ATRA) is the drug of choice for the treatment of acute promyelocytic leukemia (APL). In general, ATRA is well tolerated, but it does have side effects, the most severe of which is ATRA syndrome. We report the case of a young patient with APL treated with ATRA for induction and maintenance therapy who then developed avascular necrosis of both femoral heads. We also review cases of APL patients with osteonecrosis of the femoral head after ATRA therapy.
authors.affiliation: Division of Hematology and Oncology, Mie University School of Medicine, Mie, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Sakakura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishii
authors.forename: Eiji
authors.initials: E
authors.lastname: Usui
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Monma
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D011859:Radiography; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin