PD membrane: biological responses to different PD fluids.
In chronic peritoneal dialysis (PD) alterations of both membrane structure and function occur with time on treatment, but also in relation to frequency and severity of infectious complications. In addition, therapy-associated factors such as the dialysis fluid bioincompatibility are important determinants for the longevity of the peritoneum as the dialysis membrane. Evidence available to date suggests that the elimination of glucose degradation products from multi-chambered PD solutions is particularly important to improve peritoneal cell function as well as to reduce protein glycation and peritoneal advanced glycation end products deposition. Results from recent prospective randomized studies suggest that chronic treatment with these novel PD fluids may indeed lead to a significant improvement of clinical outcomes in chronic PD patients.
Jörres
Achim
A
Department of Nephrology and Medical Intensive Care, Charité University Hospital, Campus Virchow-Klinikum, Berlin, Germany.
Witowski
Janusz
J
D001692:Biological Transport; D015314:Dialysis Solutions / Q000009:adverse effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008566:Membranes / Q000378:metabolism; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism*
D015314:Dialysis Solutions; D005947:Glucose