title: Can heterotopic gastric mucosa present as globus pharyngeus?
abstract: We present a series of four patients presenting with symptoms leading to a provisional diagnosis of globus pharyngeus. On further investigation, they were all found to have small areas of abnormal mucosa in either their hypopharynx or proximal oesophagus, which on biopsy were reported as containing gastric-type mucosa. Following anti-reflux treatment, all patients eventually reported a cessation of symptoms. All but one patient was followed up with repeat endoscopies. We highlight the fact that biopsies reporting gastric epithelium at this anatomical site are in keeping with the diagnosis of heterotopic gastric mucosa. We review the literature and report the high incidence and natural history of this condition. Heterotopic gastric mucosa can only be diagnosed on endoscopy and is easily missed, even during such an investigation. We raise the question of whether this condition may be one of a number of factors in the aetiology of globus pharyngeus.
authors.affiliation: Department of Otolaryngology, University Hospital Aintree, Liverpool, UK. JeffreyLancaster@hotmail.com
authors.forename: J L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: S
authors.initials: S
authors.lastname: Gosh
authors.forename: R
authors.initials: R
authors.lastname: Sethi
authors.forename: S
authors.initials: S
authors.lastname: Tripathi
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002828:Choristoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003291:Conversion Disorder / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D007013:Hypopharynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D010608:Pharyngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole