Tachykinin receptors as drug targets for motility disorders.
The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.
Hoogerwerf
Willemijntje A
WA
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555-1064, USA.
Sarna
Sushil K
SK
D000818:Animals; D001337:Autonomic Agents / Q000627:therapeutic use*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors* / Q000378:metabolism
D001337:Autonomic Agents; D005765:Gastrointestinal Agents; D018039:Receptors, Tachykinin