Engineered bacteriophage-defence systems in bioprocessing.
Bacteriophages (phages) have the potential to interfere with any industry that produces bacteria as an end product or uses them as biocatalysts in the production of fermented products or bioactive molecules. Using microorganisms that drive food bioprocesses as an example, this review will describe a set of genetic tools that are useful in the engineering of customized phage-defence systems. Special focus will be given to the power of comparative genomics as a means of streamlining target selection, providing more widespread phage protection, and increasing the longevity of these industrially important bacteria in the bioprocessing environment.
Sturino
Joseph M
JM
Genomic Sciences Program, North Carolina State University, Raleigh, North Carolina 27695-7624, USA.
Klaenhammer
Todd R
TR
D001419:Bacteria / Q000235:genetics / Q000821:virology*; D001435:Bacteriophages / Q000502:physiology*; D001709:Biotechnology; D003611:Dairy Products; D005285:Fermentation; D005516:Food Microbiology; D005818:Genetic Engineering; D023281:Genomics; D016372:RNA, Antisense; D013291:Streptococcus / Q000235:genetics / Q000502:physiology / Q000821:virology; D017108:Streptococcus Phages / Q000235:genetics / Q000502:physiology*; D014779:Virus Replication
D016372:RNA, Antisense