title: Feo--transport of ferrous iron into bacteria.
abstract: Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the ferrous (Fe2+) form of iron from their environment. Enterobacterial Feo systems are composed of three proteins: FeoA, a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. We provide a review of the current literature combined with a bioinformatic assessment of bacterial Feo systems showing how they exhibit common features, as well as differences in organisation and composition which probably reflect variations in mechanisms employed and function.
authors.affiliation: School of Biological Sciences (AMS Building), University of Reading, Whiteknights, Reading, RG6 6AJ, UK.
authors.forename: Michaël L
authors.initials: ML
authors.lastname: Cartron
authors.forename: Sarah
authors.initials: S
authors.lastname: Maddocks
authors.forename: Paul
authors.initials: P
authors.lastname: Gillingham
authors.forename: C Jeremy
authors.initials: CJ
authors.lastname: Craven
authors.forename: Simon C
authors.initials: SC
authors.lastname: Andrews
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005296:Ferrous Compounds / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D009876:Operon / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D029968:Escherichia coli Proteins; D005296:Ferrous Compounds; D026901:Membrane Transport Proteins; C100775:feo protein, E coli