title: Successful treatment of diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells and basic fibroblast growth factor.
abstract: Diabetic gangrene is a non-healing skin ulcer that is often resistant to most common treatments. It is caused by microvascular disorders and an immunocompromised state which are induced by diabetes mellitus. We report a 65-year-old man with an aggressive, refractory diabetic gangrene on his left foot. Treatment of his diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells (PBMC) and basic fibroblast growth factor (bFGF) resulted in a dramatic improvement in a short time. The ulcer was completely closed and, in the past 6 months, no new ulceration has been observed. The patient is able to stand and walk by himself. Topical application of a mixture of PBMC and bFGF appears to be a useful, non-invasive and convenient method for the treatment of diabetic gangrene.
authors.affiliation: Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan. takesan@koto.kpu-m.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Asai
authors.forename: Hideya
authors.initials: H
authors.lastname: Takenaka
authors.forename: Kaori
authors.initials: K
authors.lastname: Ichihashi
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Ueda
authors.forename: Norito
authors.initials: N
authors.lastname: Katoh
authors.forename: Saburo
authors.initials: S
authors.lastname: Kishimoto
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003920:Diabetes Mellitus; D017719:Diabetic Foot / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005346:Fibroblast Growth Factors / Q000008:administration & dosage*; D005734:Gangrene / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007963:Leukocytes, Mononuclear; D008297:Male; D014945:Wound Healing
chemical_list: D005346:Fibroblast Growth Factors