Danggui-Buxue-Tang decoction has an anti-inflammatory effect in diabetic atherosclerosis rat model.
Danggui-Buxue-Tang (DBT) is a famous traditional Chinese formula. We examined the anti-inflammatory effect of it in diabetic atherosclerosis rats. DBT (3 or 6g/kg/day for 4 weeks) was orally administrated to the diabetic atherosclerosis rats, which were induced by nitric oxide inhibition (l-NAME in drinking water, 1mg/ml) plus high-fat diet. The concentrations of circulating inflammatory markers C-reactive protein (CRP) and tumour necrosis factor-alpha (TNF-alpha) and serum fructosamine were determined. The results showed that DBT had no direct effect in lowering serum fructosamine level, but can decrease the concentrations of CRP and TNF-alpha, produce a higher survival rate and less body weight loss, and decrease water intake in diabetic atherosclerosis in GK rats.
Zhang
Hongmin
H
Laboratory of Ethnopharmacology, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Chen
Shiwei
S
Deng
Xifang
X
Yang
Xuguang
X
Huang
Xi
X
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy*; D002097:C-Reactive Protein / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019270:Fructosamine / Q000097:blood; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; C477279:danggui buxue decoction; D019270:Fructosamine; D002097:C-Reactive Protein