title: New synthetic route for RGD tripeptide.
abstract: A new route was employed to synthesize RGD. First, Gly-Asp dipeptide was synthesized by a novel chemical method in two steps, including chloroacetylation of L-aspartic acid and ammonolysis of chloroacetyl L-aspartic acid. Second, Nalpha-Z- L-Arginine was reacted with Gly-Asp to synthesize RGD by the N-carboxyanhydride method. Less protected amino acids were used in this synthesis. This method possessed advantages of low cost, simplicity, and rapidity with a reasonable yield of 62% calculated from arginine. In addition, compared with the above method, a conventional solid phase method was also used to synthesize RGD, the yield was 75% calculated from the first amino acid anchored to resin.
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, P.R. China.
authors.forename: Rui-Zhen
authors.initials: RZ
authors.lastname: Hou
authors.forename: Yun-Jia
authors.initials: YJ
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Huang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Xue-Zhong
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid