Analysis of gene expression during development: lessons from the Apicomplexa.
Apicomplexans are responsible for significant human and animal disease worldwide, including malaria and toxoplasmosis. Herein we summarize recent advances in gene expression analysis in these eukaryotic pathogens, especially with respect to their developmental biology, and discuss the impact this work may have on the development of new vaccines and chemotherapeutics.
Boyle
Jon P
JP
Department of Microbiology and Immunology, Fairchild Building D305, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305-5124, USA.
Saeij
Jeroen P J
JP
Cleary
Michael D
MD
Boothroyd
John C
JC
D000818:Animals; D016782:Apicomplexa / Q000201:enzymology / Q000235:genetics*; D020224:Expressed Sequence Tags; D018507:Gene Expression Regulation, Developmental; D056572:Histone Deacetylase Inhibitors; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis
D056572:Histone Deacetylase Inhibitors