In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes.
By using an agar dilution assay, the antifungal activity of aqueous extracts prepared from Allium cepa (onion; AOE) and Allium sativum (garlic; AGE) were evaluated against Malassezia furfur (25 strains), Candida albicans (18 strains), other Candida sp. (12 strains) as well as 35 strains of various dermatophyte species and compared with the activity of a known antifungal drug, ketoconazole (KTZ). All the AOE, AGE and KTZ were found to be able to inhibit growth of all fungi tested in a dose-dependent manner with maximum of 100% at defined concentrations. The results indicate that onion and garlic might be promising in treatment of fungal-associated diseases from important pathogenic genera Candida, Malassezia and the dermatophytes.
Shams-Ghahfarokhi
Masoomeh
M
Department of Mycology, Faculty of Medical Sciences, Tarbiat Modarress University, Tehran 14115-111, Iran. shamsm@modares.ac.ir
Shokoohamiri
Mohammad-Reza
MR
Amirrajab
Nasrin
N
Moghadasi
Behnaz
B
Ghajari
Ali
A
Zeini
Farideh
F
Sadeghi
Golnar
G
Razzaghi-Abyaneh
Mehdi
M
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003883:Arthrodermataceae / Q000187:drug effects*; D002175:Candida / Q000187:drug effects; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology; D005737:Garlic; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008290:Malassezia / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019697:Onions; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000935:Antifungal Agents; D010936:Plant Extracts; D007654:Ketoconazole