Expression of EGFR and LRIG-1 in human trigeminal neurinoma.
The expression of epidermal growth factor receptor (EGFR) and leucine-rich repeats and immunoglobulin-like domain 1 (LRIG-1) in human trigeminal neurinoma was investigated and their effect on the origination and development of trigeminal neurinoma, and the relationship between them was studied. By using immunohistochemistry with tissue chip, the expression of EGFR and LRIG-1 was detected in 23 cases of trigeminal neurinoma. It was found that in the 23 cases, the expression rate of EGFR was 21.74%, while that of the LRIG-1 was 78.26%. There was a negative correlation between them. It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.
Xiong
Zongqiang
Z
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cao
Yingguang
Y
Guo
Dongsheng
D
Ye
Fei
F
Lei
Ting
T
D000328:Adult; D000368:Aged; D003390:Cranial Nerve Neoplasms / Q000378:metabolism*; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism*; D020433:Trigeminal Nerve Diseases / Q000378:metabolism*
C484445:LRIG1 protein, human; D008562:Membrane Glycoproteins; D066246:ErbB Receptors