Type 1 interferons and the virus-host relationship: a lesson in détente .
The interface between an infectious agent and its host represents the ultimate battleground for survival: The microbe must secure a niche for replication, whereas the host must limit the pathogen's advance. Among the host's arsenal of antimicrobial factors, the type 1 interferons (IFNs) induce potent defense mechanisms against viruses and are key in the host-virus standoff. Viruses have evolved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapted use of this innate cytokine system to galvanize multiple additional layers of immune defense. The plasticity that exists in these interactions provides us with a lesson in détente.
García-Sastre
Adolfo
A
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Biron
Christine A
CA
D000818:Animals; D016207:Cytokines / Q000502:physiology; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000502:physiology; D007370:Interferon Type I / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D020365:RNA Helicases / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology; D014764:Viral Proteins / Q000378:metabolism; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000276:immunology*
D016207:Cytokines; D050835:Interferon Regulatory Factors; D007370:Interferon Type I; D051193:Toll-Like Receptors; D014764:Viral Proteins; D020365:RNA Helicases