Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria.
The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non-malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that beta-hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin.
Kundaković
Tatjana
T
Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro. ktatjana@bitsyu.net
Stanojković
Tatjana
T
Juranić
Zorica
Z
Kovacević
Nada
N
D000230:Adenocarcinoma / Q000188:drug therapy; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D028082:Boraginaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity*; D010835:Phytohemagglutinins / Q000494:pharmacology; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; D010835:Phytohemagglutinins; C005503:naphthazarin