The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.
The plasma membrane calcium/calmodulin dependent ATPase (PMCA) is a calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. PMCA is the only system for calcium extrusion in the majority of cells. In excitable cells such as cardiomyocytes however, PMCA has been shown to play only a minor role in calcium homeostasis. In these cells the main mechanism of calcium extrusion is the sodium calcium exchanger. However, increasing evidence points to an important role for PMCA in signal transduction; in particular in the nitric oxide signalling pathway. In this review we will discuss recent advances that support a key role for PMCA in signal transduction and the potential for therapeutic targeting of this molecule in the treatment of cardiac diseases.
Oceandy
Delvac
D
Division of Cardiology, The University of Manchester, 1.302 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Buch
Mamta H
MH
Cartwright
Elizabeth J
EJ
Neyses
Ludwig
L
D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects*; D027682:Cation Transport Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects*; D002455:Cell Division; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D053499:Plasma Membrane Calcium-Transporting ATPases; D015398:Signal Transduction; D013347:Subcellular Fractions / Q000201:enzymology
D027682:Cation Transport Proteins; D004791:Enzyme Inhibitors; D053499:Plasma Membrane Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases