The ataxia-ome: connecting disease proteins of the cerebellum.
In this issue of Cell, Lim et al. (2006) describe a protein-protein interaction network for inherited human ataxias, a group of diseases characterized by degeneration of cerebellar Purkinje cells. This protein interactome shows that the cerebellar ataxias not only share clinical and pathological characteristics but also have proteins, processes, and pathways in common.
Humbert
Sandrine
S
Institut Curie, CNRS UMR 146, Orsay, 91405 France. sandrine.humbert@curie.u-psud.fr
Saudou
Frédéric
F
D000818:Animals; D001259:Ataxia / Q000235:genetics / Q000378:metabolism; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D009419:Nerve Tissue Proteins