title: Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats.
abstract: In Morocco, Thymus broussonetii is widely used in folk medicine for the treatment of a variety of diseases including gastroenteric and bronchopulmonary disorders and to relieve dolorous process. The antinociceptive effect of the aqueous, butanolic and ethyl acetate extracts of this species was examined in rats and mice using chemical and thermal models. The results obtained showed that aqueous and butanolic extracts exerted an antinociceptive activity in the two phases of formalin (50-300 mg/kg), tail immersion and writhing tests. Whereas, the ethyl acetate extract reduced the nociceptive response only in the second phase of formalin (100-300 mg/kg) and writhing tests. The aqueous extract, which is the most effective, contains active analgesic principles acting both centrally and peripherally. Furthermore, this antinociceptive effect has been avoided by naloxone at a dose of 1mg/kg in the first phase of formalin and hot plate tests indicating that this extract acts partly through an opioid-mediated mechanism. The present results demonstrated that Thymus broussonetii contains active constituents which possess antinociceptive activity justifying its popular use to relieve some pains.
authors.affiliation: Unité d'Ecophysiologie Animale, Département de Biologie, Faculté des Sciences Semlalia, BP 2390, Université Cadi Ayyad, 40000 Marrakech, Morocco. k_elhabazi@yahoo.fr
authors.forename: K
authors.initials: K
authors.lastname: Elhabazi
authors.forename: R
authors.initials: R
authors.lastname: Aboufatima
authors.forename: A
authors.initials: A
authors.lastname: Benharref
authors.forename: A
authors.initials: A
authors.lastname: Zyad
authors.forename: A
authors.initials: A
authors.lastname: Chait
authors.forename: A
authors.initials: A
authors.lastname: Dalal
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D046930:Thymus Plant
chemical_list: D000700:Analgesics; D009292:Narcotic Antagonists; D010936:Plant Extracts; D005557:Formaldehyde; D009270:Naloxone; D019342:Acetic Acid