title: In vitro activity of 11 antibiotics against 74 anaerobes isolated from pediatric intra-abdominal infections.
abstract: The in vitro activity of 11 antimicrobials was tested against 74 recent anaerobic isolates obtained from pretreatment cultures in pediatric patients with complicated intra-abdominal infections using the CLSI M11-A-6 agar dilution method. Carbapenems, beta-lactamase inhibitor combinations and metronidazole retained good activity, while all Bacteroides fragilis group species produced beta-lactamase and were penicillin resistant and 43% were either intermediately susceptible or resistant to clindamycin. Cefoxitin had moderate activity against B. fragilis but poor activity against Bacteroides thetaiotaomicron and other B. fragilis group isolates.
authors.affiliation: R.M. Alden Research Laboratory, 2021 Santa Monica Blvd, # 740E, Santa Monica, CA 90404, USA. ejcgmd@aol.com
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Sagar A
authors.initials: SA
authors.lastname: Vaidya
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: C
authors.initials: C
authors.lastname: Vreni Merriam
authors.forename: Helen
authors.initials: H
authors.lastname: Fernandez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents