Cu(II)-catalyzed functionalizations of aryl C-H bonds using O2 as an oxidant.
Cu(II)-catalyzed acetoxylation and halogenation of aryl C-H bonds are developed. ortho-Selectivity was observed with a wide range of 2-arylpyridine substrates. Both mono- and difunctionalizations are achieved by tuning the reaction conditions. Excellent functional group tolerance and use of O2 as a stoichiometric oxidant are significant advantages over our recently developed Pd-catalyzed C-H functionalization reactions. These newly discovered reaction conditions are also applicable for cyanation, amination, etherification, and thioetherification of aryl C-H bonds. Mechanistic investigations are carried out to gain insights into the Cu(II)-catalyzed C-H functionalization reactions.
Chen
Xiao
X
Department of Chemistry MS015, Brandeis University, Waltham, MA 02454-9110, USA.
Hao
Xue-Shi
XS
Goodhue
Charles E
CE
Yu
Jin-Quan
JQ