Central serotonergic and noradrenergic receptors in functional dyspepsia.
Functional dyspepsia is a symptom complex characterised by upper abdominal discomfort or pain, early satiety, motor abnormalities, abdominal bloating and nausea in the absence of organic disease. The central nervous system plays an important role in the conducting and processing of visceral signals. Alterations in brain processing of pain, perception and affective responses may be key factors in the pathogenesis of functional dyspepsia. Central serotonergic and noradrenergic receptor systems are involved in the processing of motor, sensory and secretory activities of the gastrointestinal tract. Visceral hypersensitivity is currently regarded as the mechanism responsible for both motor alterations and abdominal pain in functional dyspepsia. Some studies suggest that there are alterations in central serotonergic and noradrenergic systems which may partially explain some of the symptoms of functional dyspepsia. Alterations in the autonomic nervous system may be implicated in the motor abnormalities and increases in visceral sensitivity in these patients. Noradrenaline is the main neurotransmitter in the sympathetic nervous system and again alterations in the functioning of this system may lead to changes in motor function. Functional dyspepsia causes considerable burden on the patient and society. The pathophysiology of functional dyspepsia is not fully understood but alterations in central processing by the serotonergic and noradrenergic systems may provide plausible explanations for at least some of the symptoms and offer possible treatment targets for the future.
O'Mahony
S
S
Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Ireland.
Dinan
T G
TG
Keeling
P W
PW
Chua
A S B
AS
D001341:Autonomic Nervous System / Q000503:physiopathology; D002490:Central Nervous System / Q000737:chemistry / Q000503:physiopathology*; D004415:Dyspepsia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000502:physiology; D041981:Gastrointestinal Tract / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011941:Receptors, Adrenergic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D009638:Norepinephrine