title: [Fatal poisoning caused by the ingestion of a concentrated solution of 2,4-D and MCPP].
abstract: We report a clinical case of lethal ingestion of an herbicide containing 100 g/L of 2,4-D and 400 g/L de MCPP. The patient shows quickly disturbances of consciousness and cardiac arythmy, a severe metabolic acidosis and an hyperkalemia. The digestive endoscopy at day 4 after ingestion shows an haemorrhagic mucous membrane at oesophagus and stomach level with numerous aulcerations. The bronchial endoscopy shows an inflammatory mucous membrane covered with haemorrhagic liquid. At day 6, appearance of a toxic medullar aplasia. The patient dies at day 7. the autopsy shows haemorrhagic digestive lesions, a bilateral pneumopathy, lungs oedema, an ascite but no cerebral oedema.
authors.affiliation: Centre antipoison-Toxicovigilance, CHRU de Lille, 5 avenue Oscar Lambret, F 59037 Lille, France. p-nisse@chru-lille.fr
authors.forename: P
authors.initials: P
authors.lastname: Nisse
authors.forename: C
authors.initials: C
authors.lastname: Cezard
authors.forename: D
authors.initials: D
authors.lastname: Peucelle
authors.forename: A
authors.initials: A
authors.lastname: Durocher
authors.forename: M
authors.initials: M
authors.lastname: Mathieu-Nolf
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000506:poisoning*; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000506:poisoning; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006540:Herbicides / Q000506:poisoning*; D006801:Humans
chemical_list: D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; C008340:mecoprop; D008456:2-Methyl-4-chlorophenoxyacetic Acid