Intake of ruminant trans fatty acids and risk of coronary heart disease-an overview.
Epidemiological studies have shown a strong direct (positive) association between the intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA (IP-TFA). However, comparisons between ruminant TFA (R-TFA) and IP-TFA and risk of CHD have been based on quintiles of intake, which implies that the associations between the two sources of TFA and the risk of CHD were described across different ranges of intake. Controlled metabolic studies of the effect of intake of total and specific R-TFA on CHD risk factors are warranted. Moreover, further epidemiological studies of intake of R-TFA and risk of CHD in populations with a high intake of R-TFA are warranted.
Jakobsen
Marianne U
MU
Research Unit for Dietary Studies and Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark. mu@ipm.hosp.dk
Bysted
Anette
A
Andersen
Niels L
NL
Heitmann
Berit L
BL
Hartkopp
Henrik B
HB
Leth
Torben
T
Overvad
Kim
K
Dyerberg
Jørn
J
D000818:Animals; D016022:Case-Control Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D008297:Male; D012307:Risk Factors; D012418:Ruminants; D044242:Trans Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*
D004041:Dietary Fats; D044242:Trans Fatty Acids