title: The complete genome sequence of a dog: a perspective.
abstract: A complete, high-quality reference sequence of a dog genome was recently produced by a team of researchers led by the Broad Institute, achieving another major milestone in deciphering the genomic landscape of mammalian organisms. The genome sequence provides an indispensable resource for comparative analysis and novel insights into dog and human evolution and history. Together with the survey sequence of a poodle previously published in 2003, the two dog genome sequences allowed identification of more than 2.5 million single nucleotide polymorphisms within and between dog breeds, which can be used in evolutionary analysis, behavioral studies and disease gene mapping.(1)
authors.affiliation: Bioinformatics Program, Boston University, MA 02215, USA. duplexa@bu.edu
authors.forename: Soohyun
authors.initials: S
authors.lastname: Lee
authors.forename: Simon
authors.initials: S
authors.lastname: Kasif
mesh_terms: D000818:Animals; D001483:Base Sequence; D016678:Genome / Q000235:genetics*; D006801:Humans; D010802:Phylogeny