title: Relaxation and diffusion of perfluorocarbon gas mixtures with oxygen for lung MRI.
abstract: We report measurements of free diffusivity D(0) and relaxation times T(1) and T(2) for pure C(2)F(6) and C(3)F(8) and their mixtures with oxygen. A simplified relaxation theory is presented and used to fit the data. The results enable spatially localized relaxation time measurements to determine the local gas concentration in lung MR images, so the free diffusivity D(0) is then known. Comparison of the measured diffusion to D(0) will express the extent of diffusion restriction and allow the local surface-to-volume ratio to be found.
authors.affiliation: Department of Physics, Washington University, St. Louis, MO 63130, USA. ychang@wustl.edu
authors.forename: Yulin V
authors.initials: YV
authors.lastname: Chang
authors.forename: Mark S
authors.initials: MS
authors.lastname: Conradi
mesh_terms: D003627:Data Interpretation, Statistical; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D010100:Oxygen / Q000493:pharmacokinetics*; D019047:Phantoms, Imaging; D011653:Pulmonary Diffusing Capacity / Q000502:physiology; D014159:Transducers
chemical_list: D005466:Fluorocarbons; D010100:Oxygen