title: Fine-scale map of encyclopedia of DNA elements regions in the Korean population.
abstract: The International HapMap Project aims to generate detailed human genome variation maps by densely genotyping single-nucleotide polymorphisms (SNPs) in CEPH, Chinese, Japanese, and Yoruba samples. This will undoubtedly become an important facility for genetic studies of diseases and complex traits in the four populations. To address how the genetic information contained in such variation maps is transferable to other populations, the Korean government, industries, and academics have launched the Korean HapMap project to genotype high-density Encyclopedia of DNA Elements (ENCODE) regions in 90 Korean individuals. Here we show that the LD pattern, block structure, haplotype diversity, and recombination rate are highly concordant between Korean and the two HapMap Asian samples, particularly Japanese. The availability of information from both Chinese and Japanese samples helps to predict more accurately the possible performance of HapMap markers in Korean disease-gene studies. Tagging SNPs selected from the two HapMap Asian maps, especially the Japanese map, were shown to be very effective for Korean samples. These results demonstrate that the HapMap variation maps are robust in related populations and will serve as an important resource for the studies of the Korean population in particular.
authors.affiliation: DNA Link, Seoul, 120-110, Korea.
authors.forename: Yeon-Kyeong
authors.initials: YK
authors.lastname: Yoo
authors.forename: Xiayi
authors.initials: X
authors.lastname: Ke
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hong
authors.forename: Hye-Yoon
authors.initials: HY
authors.lastname: Jang
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Park
authors.forename: Sook
authors.initials: S
authors.lastname: Kim
authors.forename: TaeJin
authors.initials: T
authors.lastname: Ahn
authors.forename: Yeun-Du
authors.initials: YD
authors.lastname: Lee
authors.forename: Okryeol
authors.initials: O
authors.lastname: Song
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Rho
authors.forename: Moon Sue
authors.initials: MS
authors.lastname: Lee
authors.forename: Yeon-Su
authors.initials: YS
authors.lastname: Lee
authors.forename: Jaeheup
authors.initials: J
authors.lastname: Kim
authors.forename: Young J
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jun-Mo
authors.initials: JM
authors.lastname: Yang
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
authors.forename: Kyuchan
authors.initials: K
authors.lastname: Kimm
authors.forename: Bruce
authors.initials: B
authors.lastname: Weir
authors.forename: Lon R
authors.initials: LR
authors.lastname: Cardon
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Jung-Joo
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D044466:Asian People / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D004247:DNA / Q000032:analysis; D030561:Databases, Nucleic Acid; D005828:Genetics, Population / Q000379:methods; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic
chemical_list: D004247:DNA