Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide.
It has already been reported that 1-methylnicotinamide (MNA+), a primary metabolite of nicotinamide (vitamin B3), possesses remarkable anti-inflammatory properties [3]. This communication shows that 1-methyl-N'-(hydroxymethyl)nicotinamide (MNAF+ can be regarded as MNA+ precursor able to release simultaneously formaldehyde. Therefore, MNAF+ can be viewed as a candidate for drug with the combined anti-inflammatory and anti-bacterial properties.
Adamiec
Maciej
M
Chair of Microbiology, Medical University, Hallera 1, PL 90-647 Łódź, Poland.
Adamus
Jan
J
Ciebiada
Ireneusz
I
Denys
Andrzej
A
Gebicki
Jerzy
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D015195:Drug Design; D005557:Formaldehyde / Q000032:analysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
C514300:1-methyl-N'-(hydroxymethyl)nicotinamide; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007202:Indicators and Reagents; D005557:Formaldehyde; D009536:Niacinamide; C024058:N(1)-methylnicotinamide