Lanthanum: a safe phosphate binder.
Accumulation of inorganic phosphate due to renal functional impairment contributes to the increased cardiovascular mortality observed in dialysis patients. Phosphate plays a causative role in the development of vascular calcification in renal failure; treatment with calcium-based phosphate binders and vitamin D can further increase the Ca x PO(4) product and add to the risk of ectopic mineralization. The new generation of calcium-free phosphate binders, sevelamer and lanthanum, can control hyperphosphatemia without adding to the patients calcium load. In this article, the metabolism of lanthanum carbonate and its effects in bone, liver and brain are discussed. Although lanthanum is a metal cation its effects are not comparable to those of aluminum. Indeed, in clinical studies no toxic effects of lanthanum have been reported after up to four years of follow-up. The bioavailability of lanthanum is extremely low. The effects observed in bone are due to phosphate depletion, with no signs of direct bone toxicity yet observed in rats or humans. The liver is the main route of excretion for lanthanum carbonate, which can be localized in the lysosomes of hepatocytes. No lanthanum could be detected in brain tissue.
Persy
Veerle P
VP
University of Antwerp, Antwerp, Belgium. veerle.persy@ua.ac.be
Behets
Geert J
GJ
Bervoets
An R
AR
De Broe
Marc E
ME
D'Haese
Patrick C
PC
D000818:Animals; D001682:Biological Availability; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002114:Calcinosis / Q000188:drug therapy / Q000378:metabolism; D002986:Clinical Trials as Topic; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D007811:Lanthanum / Q000378:metabolism* / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D028044:Phosphate-Binding Proteins / Q000097:blood / Q000187:drug effects* / Q000493:pharmacokinetics
D028044:Phosphate-Binding Proteins; C119467:lanthanum carbonate; D007811:Lanthanum