Regulation of angiogenesis by hypoxia-inducible factor 1.
Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.
Hirota
Kiichi
K
Department of Anesthesia, Kyoto University Hospital, Kyoto 606-8507, Japan.
Semenza
Gregg L
GL
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology* / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D051793:Hypoxia-Inducible Factor 1