First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea.
We report the first clinical isolate of linezolid- and vancomycin-resistant Enterococcus faecium (VREF) in Korea. The minimum inhibitory concentration of linezolid was in direct proportion to the number of copies of the G2576U mutation according to sequencing and restriction fragment length polymorphism analysis of the 23S rRNA gene.
Bae
Hae-Gyung
HG
Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Sung
Heungsup
H
Kim
Mi-Na
MN
Lee
Eun-Jung
EJ
Koo Lee
Sung
S
D000081:Acetamides / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001483:Base Sequence; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007723:Korea; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D023303:Oxazolidinones / Q000494:pharmacology* / Q000627:therapeutic use; D012150:Polymorphism, Restriction Fragment Length; D016896:Treatment Outcome; D020713:Vancomycin Resistance / Q000235:genetics
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid