The influence of pH on the G-quadruplex binding selectivity of perylene derivatives.
Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
Tuntiwechapikul
Wirote
W
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiangmai 50200, Thailand. wirote@chiangmai.ac.th
Taka
Thanachai
T
Béthencourt
Mathilde
M
Makonkawkeyoon
Luksana
L
Randall Lee
T
T
D001483:Base Sequence; D001665:Binding Sites; D017931:DNA Primers; D006147:Guanine / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010569:Perylene / Q000737:chemistry / Q000378:metabolism*
D017931:DNA Primers; D010569:Perylene; D006147:Guanine