Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity.
In our effort to search for carbonyl reductases with anti-Prelog enantioselectivity, the activity and enantioselectivity of a carbonyl reductase from Candida magnoliae have been examined with various ketones of diverse structures. This carbonyl reductase catalyzed the reduction of a series of ketones, alpha- and beta-ketoesters, to anti-Prelog configurated alcohols in excellent optical purity. The usefulness of this carbonyl reductase has been demonstrated by synthesis of several chiral alcohol intermediates of pharmaceutical importance.
Zhu
Dunming
D
Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, USA.
Yang
Yan
Y
Hua
Ling
L
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000438:Alcohols / Q000138:chemical synthesis*; D002175:Candida / Q000201:enzymology*; D015394:Molecular Structure
D000438:Alcohols; D000429:Alcohol Oxidoreductases