title: Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
abstract: Nippostrongylus brasiliensis infection and ovalbumin-induced allergic lung pathology are highly interleukin (IL)-4/IL-13 dependent, but the contributions of IL-4/IL-13 from adaptive (T helper [Th]2 cells) and innate (eosinophil, basophils, and mast cells) immune cells remain unknown. Although required for immunoglobulin (Ig)E induction, IL-4/IL-13 from Th2 cells was not required for worm expulsion, tissue inflammation, or airway hyperreactivity. In contrast, innate hematopoietic cell-derived IL-4/IL-13 was dispensable for Th2 cell differentiation in lymph nodes but required for effector cell recruitment and tissue responses. Eosinophils were not required for primary immune responses. Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity.
authors.affiliation: Howard Hughes Medical Institute, Departments of Medicine and Microbiology/Immunology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: David
authors.initials: D
authors.lastname: Voehringer
authors.forename: Tiffany A
authors.initials: TA
authors.lastname: Reese
authors.forename: Xiaozhu
authors.initials: X
authors.lastname: Huang
authors.forename: Kanade
authors.initials: K
authors.lastname: Shinkai
authors.forename: Richard M
authors.initials: RM
authors.lastname: Locksley
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D005434:Flow Cytometry; D006410:Hematopoiesis / Q000276:immunology*; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000097:blood; D007249:Inflammation; D018793:Interleukin-13 / Q000276:immunology*; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology*; D008168:Lung / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D023421:Models, Animal; D009559:Nippostrongylus / Q000276:immunology; D017206:Strongylida Infections / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D018793:Interleukin-13; D015847:Interleukin-4; D007073:Immunoglobulin E