title: Isolation and characterization of the canine NKX2-5 gene.
abstract: We report the first isolation and characterization of the canine NKX2-5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2-5 across a number of different species. Given the critical role of NKX2-5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2-5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects.
authors.affiliation: Section of Internal Medicine, School of Veterinary Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea. hyun5188@kangwon.ac.kr
authors.forename: C
authors.initials: C
authors.lastname: Hyun
authors.forename: L
authors.initials: L
authors.lastname: Lavulo
authors.forename: C
authors.initials: C
authors.lastname: O'Leary
authors.forename: J-T
authors.initials: JT
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D017931:DNA Primers / Q000737:chemistry; D004285:Dogs / Q000235:genetics*; D005260:Female; D023061:Gene Order; D005801:Genes, Homeobox / Q000235:genetics*; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
chemical_list: D017931:DNA Primers; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins; C095552:NKX2-5 protein, human; D014157:Transcription Factors