Izumoring: a strategy for bioproduction of all hexoses.
Izumoring is a new concept for the bioproduction of all hexose sugars - 16 aldohexoses, eight ketohexoses and 10 hexitols -- using enzymatic and microbiological reactions. The biocatalysts necessary for the strategy were (i) d-tagatose 3-epimerase [which epimerizes all ketohexoses at C-3 of the sugar], (ii) polyol dehydrogenases [which catalyze oxidation-reduction reactions between ketohexoses and the corresponding hexitols], and (iii) aldose isomerases [which catalyze isomerization reactions between aldohexoses and corresponding aldoketoses]. All ketohexoses, aldohexoses and hexitols may be arranged in a symmetric ring connected by the biochemical reactions, allowing the design for the bioproduction of all 34 hexose sugars. The ring shows there are four entrances to the l-hexose world from the natural d-hexoses. The Izumoring ring shows clearly the relationship and the position of all 34 six carbon sugars.
Izumori
Ken
K
Rare Sugar Research Center, Kagawa University, Miki-cho Kagawa 761-0795, Japan. izumori@ag.kagawa-u.ac.jp
D019747:Aldose-Ketose Isomerases / Q000138:chemical synthesis*; D000465:Algorithms; D002384:Catalysis; D006601:Hexoses / Q000138:chemical synthesis*; D015394:Molecular Structure; D019998:Racemases and Epimerases / Q000138:chemical synthesis*
D006601:Hexoses; D019998:Racemases and Epimerases; D019747:Aldose-Ketose Isomerases