title: Maternal BMI and serum leptin concentration of infants in the first year of life.
abstract: OBJECTIVE
  To evaluate the relationship between serum leptin concentration in infants and infant and maternal BMI.
  
  
  METHODS
  75 healthy term infants aged 0-12 mo, 51 exclusively breastfed (BF) for at least 4 mo and 24 formula fed (FF), were included in a cross-sectional study. Weight, length and cranial circumference of infants and their mothers were measured, body mass index (BMI) was calculated using the formula weight (kg)/height (m2) and infant serum leptin concentration was determined.
  
  
  RESULTS
  A significant positive correlation between infant serum leptin concentration and maternal BMI was observed in BF infants (r = 0.389, p = 0.005), confirmed in a multiple regression model adjusted for infant age and infant BMI (beta = 0.065, p = 0.006), but not in FF infants. As regards the first 4 mo of life, we have already observed a positive correlation between infant serum leptin concentration and maternal BMI in BF infants (beta = 0.113, p = 0.005), but not in FF infants.
  
  
  CONCLUSIONS
  In BF infants, serum leptin concentration correlates positively with maternal BMI. Higher maternal BMI values might increase leptin levels in breast milk, and maternal adiposity could be involved in infant energy balance.
authors.affiliation: Department of Paediatrics, Regina Margherita Children's Hospital, University of Turin, Turin, Italy. francesco.savino@unito.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Savino
authors.forename: Stefania Alfonsina
authors.initials: SA
authors.lastname: Liguori
authors.forename: Roberto
authors.initials: R
authors.lastname: Oggero
authors.forename: Leandra
authors.initials: L
authors.lastname: Silvestro
authors.forename: Roberto
authors.initials: R
authors.lastname: Miniero
mesh_terms: D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D049628:Body Size; D001903:Bottle Feeding; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D012016:Reference Values
chemical_list: D020738:Leptin