title: Prognostic significance of raised cardiac troponin T in patients presenting with acute limb ischaemia.
abstract: OBJECTIVE
  To study the relation between serum cardiac troponin T (cTnT) and mortality in patients presenting with acute limb ischaemia secondary to an embolism.
  
  
  METHODS
  A two years prospective study of all patients admitted to the vascular unit with a diagnosis of acute limb ischaemia secondary to an embolism. On admission all patients had an ECG. A blood sample was taken for measurement of cTnT, CRP, serum biochemistry, full blood count and clotting. All embolectomies were performed under local anaesthesia. Patients were followed until discharge from hospital and up to twelve months after surgery.
  
  
  RESULTS
  There were 37 patients with lower limb and 2 patients with upper limb ischaemia. Twenty four patients were female and fifteen were male, with the mean age of 76 years (50-95) for women and 84 years (77-90) for men. Seventeen patients (44%) had a raised cTnT. The patients with raised cTnT were older than those with normal cTnT [86y (77-92) vs 77y (51-95), p = 0.01, t test]. The mean cTnT was 0.20 microg/L (range: 0.11-0.27). Only two patients with raised cTnT gave a history of chest pains. All of the patients with an elevated cTnT had also raised CRP. There was no significant difference in the serum creatinine in the group of patients with elevated cTnT compared to those with normal cTnT [112 micromol/L (range 98-159) vs 119 micromol/L (range: 47-177), p = ns]. The cumulative survival for cTnT+ patients at 7 days was 53% and that of cTnT- patients was 100%. The cumulative survival for cTnT+ and cTnT- patients was statistically different (p = 0.0000, chi2 = 13.1, Log Rank test). Using regression analysis, an elevated cTnT was found to be an independent predictor of outcome.
  
  
  CONCLUSIONS
  A significant proportion of patients presenting with an acutely ischaemic limb have an elevated cTnT. An elevated cTnT may be an early marker of overall disease severity and a predictor of outcome.
authors.affiliation: Department of Vascular Surgery, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, Worcestershire Royal Hospital, Worcestershire Acute Hospitals NHS Trust, UK. drms@btinternet.com
authors.forename: D
authors.initials: D
authors.lastname: Rittoo
authors.forename: M
authors.initials: M
authors.lastname: Stahnke
authors.forename: C
authors.initials: C
authors.lastname: Lindesay
authors.forename: E
authors.initials: E
authors.lastname: Grocott
authors.forename: N
authors.initials: N
authors.lastname: Hickey
authors.forename: R
authors.initials: R
authors.lastname: Downing
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004617:Embolism / Q000097:blood* / Q000150:complications / Q000401:mortality*; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000209:etiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D012720:Severity of Illness Index; D016019:Survival Analysis; D020107:Troponin T / Q000097:blood*; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D020107:Troponin T