[Correlation between dynamic contrast-enhanced MRI and expression of microvascular density in the glioma].
OBJECTIVE
To explore the correlation between microvascular density (MVD) and dynamic contrast-enhanced MRI in the glioma.


METHODS
We examined 35 patients with histologically verified glioma. Gadolinium-enhanced dynamic TurboFLASH imaging was performed preoperatively in all patients followed by conventional MRI. The steepest slope (SSmax) of curve and corresponding Tm1 in "first-pass" phase were obtained by analyzing time-signal curve. All specimens were immunostained with anti-human Factor VIII relative antigen monoclonal antibody postoperatively by streptavidin-peroxidase method to obtain the MVD. The correlation between SSmax, Tm1, and MVD was analyzed.


RESULTS
SSmax was positively correlated with MVD (r = 0.640, P < 0.01). Tml was negatively correlated with MVD (r = -0.671, P < 0.01).


CONCLUSIONS
The MVD correlates obviously with SSmax and Tml in the glioma. Analyzing the time-signal curve of dynamic contrast-enhanced MRI is helpful to predict the angiogenesis in the glioma.
Yin
Dan
D
Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China). yindan3418@126.com
Wang
Xiao-yi
XY
Yan
Xue-bin
XB
Liao
Wei-hua
WH
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000098:blood supply*; D002648:Child; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D005910:Glioma / Q000098:blood supply*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009389:Neovascularization, Pathologic
D003287:Contrast Media; D005682:Gadolinium