[Interactions in solution between cyclodextrins and statins].
Cyclodextrins (CDs) are cyclic oligosaccharides, capable of forming inclusion complexes with hydrophobic molecules in aqueous solution and therefore, of improving the bioavailability of many drugs. They are biocompatible with living cells and do not cause toxic side effects. In this study, interactions in aqueous solutions between chemically different CDs and lovastatin and simvastatin, respectively, were investigated. It was found that the solubility of both statins can be considerably increased by the CD derivatives. The influence of the chemical structure of CD and of the temperature and pH on the solubility of the statin derivatives is described. Possible ways of increasing the solubility of these cholesterol-lowering drugs and their utilization in practice are also outlined.
Süle
András
A
ELTE TTK Kolloidkémiai es Kolloidtechnológiai Tanszék, Budapest.
Szente
Lajos
L
Csempesz
Ferenc
F
D003505:Cyclodextrins / Q000737:chemistry*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry*; D008148:Lovastatin / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D019821:Simvastatin / Q000737:chemistry; D012995:Solubility; D012996:Solutions
D003505:Cyclodextrins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D012996:Solutions; D008148:Lovastatin; D019821:Simvastatin