A data model to predict HER2 status in breast cancer based on the clinical and pathologic profiles of a large patient population at a single institution.
Recently published clinical trial data have produced compelling evidence for increased survival when Herceptin is administered to patients whose tumors are HER2 amplified. Therefore, the accuracy of HER2 status is essential to determine which patients should or should not receive Herceptin. Although HER2 results obtained by FISH and IHC are often in agreement, there is a persistent group of cases in which results are discordant, particularly among tumors with intermediate results. A multivariable analysis was undertaken to determine relative significance of various clinical and pathologic findings for patients diagnosed with infiltrating ductal carcinoma, and a data model was produced that predicts which patients are most likely to have HER2 amplified tumors. Correlates of HER2 amplification were higher Scarff-Bloom-Richardson grade, younger age at diagnosis, and a comedo ductal carcinoma in situ component.
Crowe
Joseph P
JP
Department of General Surgery-Breast Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A-80, Cleveland, OH 44195, USA. crowej@ccf.org
Patrick
Rebecca J
RJ
Rybicki
Lisa A
LA
Escobar
Pedro F
PF
Weng
David
D
Thomas Budd
G
G
Tubbs
Raymond R
RR
Procop
Gary W
GW
Hicks
David G
DG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005784:Gene Amplification / Q000502:physiology; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D012042:Registries
D018719:Erb-b2 Receptor Tyrosine Kinases