title: [Expression of matrix metalloproteinase 2 in oral verruvous carcinoma and squamous cell carcinoma].
abstract: OBJECTIVE
  To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma.
  
  
  METHODS
  Thirty cases were divided into 3 groups: verruvous carcinoma (n = 10), well-differentiated squamous cell carcinoma (n = 15) and moderately or poorly differentiated squamous cell carcinoma (n = 5). Reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of MMP2 mRNA in the carcinoma tissues and matched normal tissues from 3 groups above.
  
  
  RESULTS
  The expression of MMP2 mRNA in the carcinoma tissues was significantly higher than that in their matched normal tissues (P < 0.05). The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P < 0.05). However, the expression of MMP2 mRNA was not obviously different between well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P > 0.05).
  
  
  CONCLUSIONS
  The expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma tissues was significantly higher than that in their matched normal tissues. The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in squamous cell carcinoma.
authors.affiliation: Departerment of Oral and Maxillofacial Sturgery, Xiangya Hospital, Central South University, Changsha 410008, China. Tangzhangui@yahoo.com.cn
authors.forename: Zhan-gui
authors.initials: ZG
authors.lastname: Tang
authors.forename: Jin-mao
authors.initials: JM
authors.lastname: Li
authors.forename: Zhen-zhen
authors.initials: ZZ
authors.lastname: Hong
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Yu
authors.forename: Cheng-hui
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D018289:Carcinoma, Verrucous / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D020778:Matrix Metalloproteinase 2