Polymeric core-shell nanoparticles for therapeutics.
1. Nanobiotechnologies have recently attracted significant attention from chemists, biologists, engineers and pharmaceutical scientists. In particular, they have been widely applied to improve drug, protein/peptide and gene delivery. 2. This review presents recent advances in the field of drug, protein/peptide and gene delivery using natural and synthetic polymer nanoparticles and explains how polymeric nanoparticles are specifically designed to suit the needs for targeted delivery of small molecular drugs, proteins/peptides and genes. In addition, some of the challenges and prospects for these technologies are discussed.
Yang
Yi-Yan
YY
Institute of Bioengineering and Nanotechnology, Singapore. yyyang@ibn.a-star.edu.sg
Wang
Yong
Y
Powell
Ross
R
Chan
Peggy
P
D000284:Administration, Oral; D000818:Animals; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D007408:Intestinal Absorption; D053758:Nanoparticles; D036103:Nanotechnology / Q000639:trends; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000639:trends; D014162:Transfection / Q000379:methods; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics / Q000378:metabolism
D004337:Drug Carriers; D007004:Hypoglycemic Agents; D007328:Insulin; D011108:Polymers; D011506:Proteins; D034741:RNA, Small Interfering; D004247:DNA; D040301:Vascular Endothelial Growth Factor Receptor-2