title: A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential.
abstract: Solid pseudopapillary tumor is a rare, indolent neoplasm almost exclusively seen in the pancreas. We describe an unusual case of solid pseudopapillary tumor arising in the greater omentum of a 45-year-old man with subsequent multiple liver metastases and peritoneal dissemination. The patient underwent a total of ten laparotomies and died of unresectable disease 8 years after the initial presentation. Microscopically, the primary tumor and the relapsed tumors consistently exhibited identical growth patterns, which were characterized by solid sheets intermingling with pseudopapillary arrangements of uniformly small cells. Immunohistochemical staining was diffusely positive for vimentin and focally positive for alpha-1-antitrypsin. These features were compatible with those of conventional pancreatic solid pseudopapillary tumors. We also performed quantitative evaluation of Ki-67 immunoreactivity and mitotic figures, which indicated malignant transformation of this extremely rare tumor. This is the first detailed report of solid pseudopapillary tumor arising outside the pancreas complicated by repetitive liver metastases and peritoneal carcinomatosis, suggesting the existence of a more lethal subgroup of tumors.
authors.affiliation: Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Tokyo, 104-0045, Japan.
authors.forename: Taizo
authors.initials: T
authors.lastname: Hibi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ojima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Tomoo
authors.initials: T
authors.lastname: Kosuge
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sano
authors.forename: Michiie
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
authors.forename: Susumu
authors.initials: S
authors.lastname: Yamasaki
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D002291:Carcinoma, Papillary / Q000556:secondary* / Q000601:surgery; D003110:Colonic Neoplasms / Q000556:secondary / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000097:blood; D007813:Laparotomy; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008643:Mesentery / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009852:Omentum / Q000473:pathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000601:surgery; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin