Xanthine oxidase inhibiting flavonol glycoside from Amberboa ramosa.
A new flavonol glycoside (1) has been isolated from the ethyl acetate soluble fraction of Amberboa ramosa and assigned the structure 5,7,4'-trihydroxy-3,8-dimethoxylflavone 5-O-beta-D-gluco-pyranoside (1). In addition, 6,4'-dihydroxy-3,5,7-trimethoxyflavone (2), 5,7-dihydroxy-4'-methoxyflavone (3) and (23R)-5alpha-cycloart-24-ene-3beta,21,23-triol (4) have also been reported for the first time from this species. The structures were deduced on the basis of 1D and 2D NMR techniques. The compounds 1-3 displayed weak to moderate inhibition against the xanthine oxidase enzyme.
Khan
Sher Bahadar
SB
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan.
Afza
Nighat
N
Malik
Abdul
A
Azhar-Ul-Haq
Perveen
Shagufta
S
Ahmad
Ijaz
I
Ejaz
Asma
A
Choudhary
M Iqbal
MI
D019659:Asteraceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
C512660:5,7,4'-trihydroxy-3,8-dimethoxylflavone 5-O-beta-D-gluco-pyranoside; D047309:Flavones; D006027:Glycosides; D014969:Xanthine Oxidase