title: Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case.
abstract: Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Higuchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Hatori
authors.forename: Koichi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Imai
authors.forename: Ken
authors.initials: K
authors.lastname: Takasaki
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery / Q000628:therapy*; D001650:Bile Duct Neoplasms / Q000601:surgery / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic; D017252:CD3 Complex / Q000276:immunology*; D018281:Cholangiocarcinoma / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008207:Lymphatic Metastasis; D008213:Lymphocyte Activation; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017252:CD3 Complex