Generalized mucinosis in a patient with erythroderma.
We describe an 81-year-old Japanese patient with erythroderma overlapping with widespread and symmetrical deposits of mucin in the upper dermis. Clinically, the mucinous lesions on the nape and upper trunk were localized papular mucinosis. Histologically, there was a perivascular infiltrate of lymphohistiocytic cells mingled with plasma cells in the upper dermis but no sclerosis. Immunohistochemical staining revealed that more than 90% of these infiltrating plasma cells produced immunoglobulin lambda-chain. Both the erythroderma and generalized mucinosis responded to topical steroid and PUVA therapy. To the best of our knowledge, this is the first case of erythroderma accompanied by generalized mucinosis.
Fujimura
Taku
T
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. fujimura@gonryo.med.tohoku.ac.jp
Okuyama
Ryuhei
R
Nakagawa
Satoshi
S
Terui
Tadashi
T
Aiba
Setsuya
S
D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D003873:Dermatitis, Exfoliative / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D004060:Diflucortolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D017520:Mucinoses / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D011701:PUVA Therapy / Q000379:methods; D012867:Skin / Q000473:pathology*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; C013486:diflucortolone valerate; D004060:Diflucortolone