Impaired detection of silent interval change in schizophrenia.
The reliably observed reduction in the mismatch negativity response to a change in sound duration in schizophrenia patients may be related to more widespread temporal processing impairments associated with the disorder. This study explored whether individuals with schizophrenia would show electrophysiological evidence of automatic deficits in the ability to detect changes in a regularly repeating interval between two tones. The established pattern was a repeating sequence of a pair of 50-ms tones with a 50-ms silent interval between them. In 8% of pairs, the silent interval between tones was increased to 125 ms. Significant differences in the response to the deviant tone pair in the patient group were consistent with impaired representation of the temporal relationship between sounds.
Todd
Juanita
J
Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Behavioural Science, University of Western Australia, Crawley, Western Australia, Australia. Juanita.Todd@newcastle.edu.au
D000161:Acoustic Stimulation; D000328:Adult; D001306:Auditory Pathways / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology*; D001308:Auditory Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D013998:Time Perception / Q000502:physiology*