title: High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan.
abstract: BACKGROUND
  Hepatitis E virus (HEV) causes acute onset of jaundice and a high case-fatality ratio in pregnant women. We provide a clinical description of hospitalized case patients and assess the specific impact on pregnant women during a large epidemic of HEV infection in a displaced population in Mornay camp (78,800 inhabitants), western Darfur, Sudan.
  
  
  METHODS
  We reviewed hospital records. A sample of 20 clinical cases underwent laboratory confirmation. These patients were tested for immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody to HEV (serum) and for amplification of the HEV genome (serum and stool). We performed a cross-sectional survey in the community to determine the attack rate and case-fatality ratio in pregnant women.
  
  
  RESULTS
  Over 6 months, 253 HEV cases were recorded at the hospital, of which 61 (24.1%) were in pregnant women. A total of 72 cases (39.1% of those for whom clinical records were available) had a diagnosis of hepatic encephalopathy. Of the 45 who died (case-fatality ratio, 17.8%), 19 were pregnant women (specific case-fatality ratio, 31.1%). Acute hepatitis E was confirmed in 95% (19/20) of cases sampled; 18 case-patients were positive for IgG (optical density ratio > or =3), for IgM (optical density ratio >2 ), or for both, whereas 1 was negative for IgG and IgM but positive for HEV RNA in serum. The survey identified 220 jaundiced women among the 1133 pregnant women recorded over 3 months (attack rate, 19.4%). A total of 18 deaths were recorded among these jaundiced pregnant women (specific case-fatality ratio, 8.2%).
  
  
  CONCLUSIONS
  This large epidemic of HEV infection illustrates the dramatic impact of this disease on pregnant women. Timely interventions and a vaccine are urgently needed to prevent mortality in this special group.
authors.affiliation: European Programme for Intervention Epidemiology Training, Stockholm, Sweden.
authors.forename: Delia
authors.initials: D
authors.lastname: Boccia
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guthmann
authors.forename: Hilde
authors.initials: H
authors.lastname: Klovstad
authors.forename: Nuha
authors.initials: N
authors.lastname: Hamid
authors.forename: Mercedes
authors.initials: M
authors.lastname: Tatay
authors.forename: Iza
authors.initials: I
authors.lastname: Ciglenecki
authors.forename: Jacques-Yves
authors.initials: JY
authors.lastname: Nizou
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Nicand
authors.forename: Philippe Jean
authors.initials: PJ
authors.lastname: Guerin
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D016751:Hepatitis E / Q000401:mortality*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012367:RNA, Viral / Q000097:blood; D012036:Refugees; D012189:Retrospective Studies; D013397:Sudan / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral