ICAM-1 and VCAM-1 expression following aneurysmal subarachnoid hemorrhage and their possible role in the pathophysiology of subsequent ischemic deficits.
BACKGROUND
The pathophysiology of ischemic cerebral lesions following aneurysmal subarachnoid hemorrhage (SAH) is poorly understood. There is growing evidence that inflammatory reactions could be involved in the pathogenesis of such delayed occurring ischemic lesions. The aim of this study was to evaluate adhesion molecules with regard to these lesions following SAH.


METHODS
Serum and cerebrospinal fluid (CSF) samples were taken daily from 15 patients up to day 9 after SAH and evaluated for intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1).


RESULTS
CSF and serum samples correlated well during nearly the whole time course (p < 0.0001). A secondary increase in ICAM-1 and VCAM-1 in the serum and CSF correlated with an increase in flow velocity in the transcranial Doppler (p > 0.0001 and p < 0.007) but not to a delayed lesion in the CT scan.


CONCLUSIONS
We believe that inflammatory processes are involved in the pathogenesis of cerebral vasospasm but they might only be a part of a multifactorial pathogenesis.
Rothoerl
Ralf Dirk
RD
Department of Neurosurgery, University of Regensburg, Regensburg, Germany. rdrothoerl@aol.com
Schebesch
Karl-Michael
KM
Kubitza
Marion
M
Woertgen
Chris
C
Brawanski
Alexander
A
Pina
Ana-Luisa
AL
D000293:Adolescent; D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000097:blood* / Q000134:cerebrospinal fluid / Q000503:physiopathology; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid; D002532:Intracranial Aneurysm / Q000097:blood* / Q000134:cerebrospinal fluid / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000134:cerebrospinal fluid / Q000503:physiopathology; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid; D020301:Vasospasm, Intracranial / Q000097:blood* / Q000134:cerebrospinal fluid / Q000503:physiopathology
D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1