title: [Neurofibromatosis type 1 complications in the pediatric age: follow-up of a hundred cases].
abstract: Neurofibromatosis 1 (NF1) is a frequent genetic disease. Diagnostic criterias were established in 1988. The patients can exhibit various and unpredictable complications.
  
  
  OBJECTIVE
  To check the efficiency of a coordinated follow-up in specialized multidisciplinary centers providing a higher quality of management and to have a better knowledge of the complications including their true frequencies.
  
  
  METHODS
  We report a serie of 100 NF1 children who were followed-up during 4 years in a specialized center at the Tours University Hospital. Three hospital check-up at 2-5, 6-7, 14-15 years of age were performed as well as an annual physical examination.
  
  
  RESULTS
  In our serie, the mean age was 7.8 years old with a sex ratio of 1. The mean age at diagnosis was 3.8 years old and the main diagnosis criteria were the café-au-lait spots and the family history for 80% of the patients. The optic nerve glioma has a low frequency of 5%. Learning disabilities clearly represent the most frequent complication (46% of the patients).
  
  
  CONCLUSIONS
  An early detection of these difficulties is a priority for the appropriate management of these children.
authors.affiliation: Service de neurologie et neurochirurgie pédiatrique, centre de pédiatrie Gatien-de-Clocheville, CHRU de Tours, 49, boulevard Béranger, 37044 Tours cedex 01, France.
authors.forename: E
authors.initials: E
authors.lastname: Bonnemaison
authors.forename: B
authors.initials: B
authors.lastname: Roze-Abert
authors.forename: G
authors.initials: G
authors.lastname: Lorette
authors.forename: D
authors.initials: D
authors.lastname: Sirinelli
authors.forename: M
authors.initials: M
authors.lastname: Boscq
authors.forename: S
authors.initials: S
authors.lastname: Mazjoub
authors.forename: B
authors.initials: B
authors.lastname: De Courtivron
authors.forename: C
authors.initials: C
authors.lastname: Bonnard
authors.forename: F
authors.initials: F
authors.lastname: Despert
authors.forename: A
authors.initials: A
authors.lastname: Toutain
authors.forename: J
authors.initials: J
authors.lastname: Maheut-Lourmière
authors.forename: M-A
authors.initials: MA
authors.lastname: Barthez
authors.forename: P
authors.initials: P
authors.lastname: Castelnau
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007859:Learning Disabilities / Q000209:etiology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis*