Cell and molecular biology of human lacrimal gland and nasolacrimal duct mucins.
The old concept that the lacrimal gland is only a serous gland has been superseded by the finding that lacrimal acinar cells are able to produce mucins--high-molecular-weight proteins--the major mass being carbohydrates with the common feature of tandem repeats of amino acids rich in serine, threonine, and proline in the central domain of the mucin core peptide. At the ocular surface, maintenance of the tear film, lubrication, and provision of a pathogen barrier on the epithelia, conjunctiva, and cornea have been shown to be facilitated by mucins that are present in membrane-anchored (lining epithelial cells) or secreted (goblet cells) form. Also in the lacrimal gland, both membrane-anchored (MUCs 1, 4, and 16) and secreted (MUCs 5B and 7) mucins have been identified. The lacrimal gland is the main contributor to the aqueous portion of the tear film. It is part of the lacrimal apparatus that comprises, together with the lacrimal gland, the paired lacrimal canaliculi, the lacrimal sac, and the nasolacrimal duct, which collects the tear fluid and conveys it into the nasal cavity. In this review, the latest information regarding mucin function in the human lacrimal gland and the human efferent tear ducts is summarized with regard to mucous epithelia integrity, rheological and antimicrobial properties of the tear film and tear outflow, age-related changes, and certain disease states such as the pathogenesis of dry eye, dacryostenosis, and dacryolith formation.
Paulsen
Friedrich
F
Department of Anatomy and Cell Biology, Martin Luther University, Halle-Wittenberg, 06097 Halle, Germany.
D006801:Humans; D007765:Lacrimal Apparatus / Q000033:anatomy & histology / Q000166:cytology* / Q000378:metabolism*; D009077:Mucins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009301:Nasolacrimal Duct / Q000166:cytology / Q000378:metabolism*
D009077:Mucins