title: Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.
abstract: Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice.
authors.affiliation: Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza Alley 2, Moscow 107564, Russia. asapt@aha.ru.
authors.forename: Marianna O
authors.initials: MO
authors.lastname: Orlova
authors.forename: Konstantin B
authors.initials: KB
authors.lastname: Majorov
authors.forename: Irina V
authors.initials: IV
authors.lastname: Lyadova
authors.forename: Eugenii B
authors.initials: EB
authors.lastname: Eruslanov
authors.forename: Cyr E
authors.initials: CE
authors.lastname: M'lan
authors.forename: Celia M T
authors.initials: CM
authors.lastname: Greenwood
authors.forename: Erwin
authors.initials: E
authors.lastname: Schurr
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Apt
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D018925:Chemokines; D016207:Cytokines