Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome.
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD.
Laurent
Julien
J
CePo-Centre Pluridisciplinaire d'Oncology, Avenue PierreDecker, 4CH Lausanne, Switzerland.
Paly
Evelyne
E
Marche
Patrice N
PN
London
Jacqueline
J
D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D051379:Mice; D008822:Mice, Transgenic; D013482:Superoxide Dismutase / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000473:pathology*
D013482:Superoxide Dismutase