title: Shutting down Alzheimer's.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000276:immunology / Q000502:physiology; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008568:Memory / Q000502:physiology; D051379:Mice; D009154:Mutation; D016874:Neurofibrillary Tangles / Q000737:chemistry / Q000473:pathology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D058225:Plaque, Amyloid / Q000737:chemistry / Q000473:pathology; D053764:Presenilin-1; D053766:Presenilin-2; D016875:tau Proteins / Q000032:analysis / Q000037:antagonists & inhibitors
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D004791:Enzyme Inhibitors; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse