Genomic instability and tumor stem cells.
Wang et al. point to the existance of a common progenitor tumor stem cell that gives rise to genomically unstable progeny in malignant melanoma. Although it is not known what creates this genomic instability, given the presence of testis antigens in melanoma, it is tempting to speculate that it is caused by a collision of meiotic and mitotic pathways.
Grichnik
James M
JM
Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. grich001@mc.duke.edu
D042822:Genomic Instability; D006801:Humans; D008540:Meiosis; D008545:Melanoma / Q000235:genetics* / Q000473:pathology*; D008938:Mitosis; D013234:Stem Cells / Q000473:pathology*