title: SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes.
abstract: Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG-3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2 = 0.68, P < 0.05) but also in type 2 patients (R2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes.
authors.affiliation: Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606 8507, Japan. yamada@metab.kuhp.kyoto-u.ac.jp
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Fukuda
authors.forename: Shimpei
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Masaya
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tsukiyama
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Nagashima
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kentaro
authors.initials: K
authors.lastname: Toyoda
authors.forename: Mariko
authors.initials: M
authors.lastname: Sassa
authors.forename: Shogo
authors.initials: S
authors.lastname: Funakoshi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Inagaki
authors.forename: Ataru
authors.initials: A
authors.lastname: Taniguchi
authors.forename: T Shun
authors.initials: TS
authors.lastname: Sato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
mesh_terms: D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000378:metabolism*; D016381:Islets of Langerhans Transplantation
chemical_list: D001786:Blood Glucose; D007328:Insulin