title: Susceptibility to vaginal candidiasis under different conditions in mice.
abstract: In order to study the susceptibility of murine vaginal mucosa to Candida albicans under different conditions, vaginal lavage fluid and vaginal tissue of mice were observed and compared between murine models with normal immune system (estrogen-treated mice) and immunosuppressed murine model, and between primary infection model of vaginal candidiasis and secondary infection one. The average level of colony forming unit (CFU) from the immuosuppressed group was higher than that from estrogen-treated group at each time point and the peak time was delayed. The differences between the two groups were statistically significant (P < 0.05) from the fourth day after inoculation. A significant difference existed in the average level of CFU between the control group and the estrogen-treated group (P < 0.05), and between the control group and the immuosuppressed group (P < 0.01). It was concluded that the vaginal mucosa from the immunosuppressed mice is more susceptible to Candida albicans and no difference is found in susceptibility between mice with primary infection and secondary infection.
authors.affiliation: Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
authors.forename: Jiawen
authors.initials: J
authors.lastname: Li
authors.forename: Shanjuan
authors.initials: S
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Fang T
authors.initials: FT
authors.lastname: Qin
authors.forename: Juan
authors.initials: J
authors.lastname: Ding
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.forename: Shaoru
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000209:etiology* / Q000276:immunology*; D004198:Disease Susceptibility; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D016867:Immunocompromised Host; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D014621:Vagina / Q000382:microbiology
chemical_list: D004967:Estrogens