title: Mitochondrial Ca2+ transport, permeability transition and oxidative stress in cell death: implications in cardiotoxicity, neurodegeneration and dyslipidemias.
abstract: Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.
authors.affiliation: Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brazil. anibal@unicamp.br
authors.forename: Anibal E
authors.initials: AE
authors.lastname: Vercesi
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Kowaltowski
authors.forename: Helena C F
authors.initials: HC
authors.lastname: Oliveira
authors.forename: Roger F
authors.initials: RF
authors.lastname: Castilho
mesh_terms: D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D016923:Cell Death; D050171:Dyslipidemias / Q000503:physiopathology; D006321:Heart / Q000187:drug effects; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D018384:Oxidative Stress; D010539:Permeability; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000503:physiopathology
chemical_list: D017382:Reactive Oxygen Species; D002118:Calcium