title: Pulmonary adenocarcinoma associated with SAPHO syndrome difficult to differentiate from multiple bone metastasis.
abstract: The patient was a 57-year-old man with a chief complaint of anterior chest pain who was diagnosed with clinical stage IV (c-T2N2M1) non-small-cell lung cancer (adenocarcinoma). Tenderness in the sternoclavicular joint, acne, periodontitis, and palmoplantar pustulosis were evident, and SAPHO syndrome was diagnosed. SAPHO syndrome is a rare disorder that results in synovitis, acne, pustulosis, hyperostosis, and osteomyelitis. Bone scintigraphy showed tracer accumulation in the costal cartilage, sternoclavicular joint, and cervical vertebrae 6-7. Although the bone lesions of SAPHO syndrome were difficult to differentiate from bone metastasis of pulmonary adenocarcinoma, metastatic bone tumors were ruled out by magnetic resonance imaging, computed tomography, and fluorodeoxyglucose positron emission tomography. There have been no previously reported cases of lung cancer with comorbid SAPHO syndrome. We report such a case and discuss the relevant literature, particularly that concerned with the evaluation of bone lesions.
authors.affiliation: Department of Medical Oncology, Tokai University School of Medicine, Isehara.
authors.forename: Reishi
authors.initials: R
authors.lastname: Shibakuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Seto
authors.forename: Kazutsugu
authors.initials: K
authors.lastname: Uematsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Seki
authors.forename: Makiko
authors.initials: M
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Mayuko
authors.initials: M
authors.lastname: Ohta
authors.forename: Kenji
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications* / Q000175:diagnosis; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged