Leukocyte function-associated antigen-1: structure, function and application prospects.
This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.
Xingyuan
Ma
M
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China.
Wenyun
Zheng
Z
Tianwen
Wang
W
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D001327:Autoimmune Diseases / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000503:physiopathology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000737:chemistry* / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1