Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease.
The case reported here of an infant who presented with Pneumocystis carinii pneumonia, CD4+ lymphopenia, and hypogammaglobulinemia attributable to severe combined immunodeficiency (SCID). This report discussed treatment of Mycobacterium bovis bacillus Calmette-Guèrin disease with unrelated cord blood transplantation in addition to antituberculous therapy, by adoptively transferring donor immunity with induction of mixed chimerism. Because of the unique nature of umbilical cord blood hematopoietic cells, engraftment without conditioning may be possible in SCID patients without fully matched donors.
Jaing
Tang-Her
TH
Division of Hematology and Oncology, Chang Gung University and Children's Hospital, Taiwan.
Lee
Wen-I
WI
Lin
Tzou-Yien
TY
Huang
Jing-Long
JL
Chen
Shih-Hsiang
SH
Chow
Robert
R
D036101:Cord Blood Stem Cell Transplantation; D005500:Follow-Up Studies; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008297:Male; D009163:Mycobacterium bovis; D016511:Severe Combined Immunodeficiency / Q000276:immunology* / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000382:microbiology*