Formal total synthesis of the cytotoxic marine ascidian alkaloid haouamine A.
[reaction: see text] Described is a convergent 13-step synthesis of a pentacyclic compound which has previously been transformed into haouamine A, therefore constituting a formal total synthesis of this unique marine alkaloid.
Jeong
Jeannie H
JH
Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA.
Weinreb
Steven M
SM
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008386:Marine Biology; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata / Q000737:chemistry*; D000097566:Cyclophanes
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D008387:Marine Toxins; C474767:haouamine A; D000097566:Cyclophanes