title: [Mediastinal involvement in the course of proliferative diseases in children in the materials of one institution].
abstract: The mediastinum region may be the primary or secondary localization of neoplasms. The aim of our study was the assessment of clinical symptoms, histopathology and outcome of mediastinal tumours in children.
  
  
  METHODS
  A group of 27 children, chosen from the group of 128 patients with malignancies, which were treated in the years 2000-2004 in the Oncology and Haematology Unit of the Paediatric Department in Katowice, has been studied. In this group there were 14 boys and 13 girls at the age between 2 and 12 years. We analysed the clinical symptoms prior to the diagnosis and the duration of these symptoms, histologic type of tumours and results of treatment.
  
  
  RESULTS
  The primary localization in the mediastinum was diagnosed in 23 patients (85,2%) among them 15 (55,5%) of these children have been diagnosed as having Hodgkin's disease, and in 8 (29,6%) non Hodgkin's lymphoproliferative disease. Four of the children (14,8%) had mediastinal secondary localization of solid tumours (2 - neuroblastoma, 1 - carcinoma suprarenalis, 1 - carcinoma epitheliale of unknown origin). The most frequent symptoms were: fever (70,3%), weakness (66,6%), cough (55,5%), madiastinalpain (33,3%). The duration of these symptoms prior to the diagnosis was between 5 days and 182 clays.
  
  
  CONCLUSIONS
  1. In the group of neoplasms localized in the mediastinum, lymphoproliferative diseases are the most frequently diagnosed disorders. 2. In case of fever of unclear etiology and persistent cough, it is necessary to exclude mediastinal malignancy. 3. There is a need to improve the system of oncological education for medical students and doctors.
authors.affiliation: Oddział Onkologii, Hematologii i Chemioterapii Klinika Pediatrii SAM, Gómoślaskie Centrum Zdrowia Dziecka i Matki w Katowicach. onkohematologia@wp.pl
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sobol
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mizia
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Musioł
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kuleta-Bosak
authors.forename: Jacek
authors.initials: J
authors.lastname: Pajak
authors.forename: Michał
authors.initials: M
authors.lastname: Pyda
authors.forename: Teresa
authors.initials: T
authors.lastname: Madera-Buchta
authors.forename: Halina
authors.initials: H
authors.lastname: Woś
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D008482:Mediastinum / Q000473:pathology*; D009447:Neuroblastoma / Q000175:diagnosis / Q000628:therapy; D016522:Oncology Service, Hospital / Q000706:statistics & numerical data; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D016019:Survival Analysis