[Pathologic features and prognosis of 21 children with isolated proteinuria].
OBJECTIVE
To discuss the pathologic features, treatment and prognosis of the children with isolated proteinuria (IP).


METHODS
Twenty-one children with IP were enrolled according to their renal biopsy and were followed up for 0.5 to 10 years.


RESULTS
Renal biopsy was performed in all children. Among them 13 were mesangial proliferation glomerulonephritis (MsPGN) (including 3 minor, 6 moderate, and 4 severe ones), 2 minimal change nephritis (MCN), 3 IgA nephropathy (IgAN) (1 in Grade I and 2 in Grade II), 2 focal segmemtal glomerulosclerosis (FSGS) and 1 endocapillary proliferative glomerulonephritis (EnPGN). Interstitial changes could be found in MsPGN and FSGS mostly, presenting interstitial fibrosis, infiltration of inflammatory cells, atrophy of renal tubule, and the vacuolar degeneration of epithelia. All children accepted the medical treatment except the EnPGN case. Fifteen children recovered with no relapse; proteinuria persisted in 3 severe MsPGN and FSGS cases; 2 got the impaired renal function accompanied by persistent proteinuria; and 1 had hypertension.


CONCLUSIONS
The different degrees of renal damage can be found in all IP children who have persistent proteinuria. Most patients can get good outcome after aggressive therapies. However, the prognosis of those with severe MsPGN and FSGS was not so optimistic, and some reno-protective treatments should be given to postpone the deterioration of the renal function.
Dang
Xi-qiang
XQ
Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. happydang@tom.com
Yi
Zhu-wen
ZW
He
Xiao-jie
XJ
Bai
Hai-tao
HT
Yang
Hua-bin
HB
Xu
Zi-chuan
ZC
D000293:Adolescent; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology / Q000473:pathology*