title: Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature.
abstract: Myeloid sarcoma can involve any anatomic site, but involvement of the gynecologic tract is uncommon. We describe 11 women, 17 to 60 years old, with myeloid sarcoma involving the gynecologic tract, including 5 patients in whom myeloid sarcoma presented as an isolated mass. The uterus was the most frequently involved anatomic site, in 8 patients (5 corpus, 3 cervix). Each neoplasm diffusely infiltrated normal structures, and, cytologically 7 tumors were immature, 3 were differentiated, and 1 was blastic. In 9 cases assessed, immunohistochemical stains showed that all neoplasms were positive for myeloperoxidase and lysozyme; CD117 was positive in 7 of 8 cases, and cytochemical staining for naphthol AS-D chloroacetate was positive in all 6 neoplasms analyzed. Following chemotherapy, complete remission and long-term survival were achieved in a subset of patients, as was particularly true for 2 patients (cases 8 and 10), with complete remission 12.5 and 31 years after diagnosis, respectively.
authors.affiliation: Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Mar Garcia
authors.initials: MG
authors.lastname: Garcia
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Knoblock
authors.forename: Weina
authors.initials: W
authors.lastname: Chen
authors.forename: Apostolia M
authors.initials: AM
authors.lastname: Tsimberidou
authors.forename: John T
authors.initials: JT
authors.lastname: Manning
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D023981:Sarcoma, Myeloid / Q000201:enzymology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D009195:Peroxidase; D009113:Muramidase