title: Trachyonychia: case report and review of the literature.
abstract: Trachyonychia is the term used to describe nail plate roughness, pitting, and ridging that may affect 1 to 20 nails. Alopecia areata, psoriasis, lichen planus, atopic dermatitis, ichthyosis vulgaris, as well as other skin conditions have been associated with trachyonychia, but the causal relationship is often challenging to demonstrate histologically. Clinical evidence of these cutaneous disorders in conjunction with a nail matrix biopsy may help elucidate an etiology of trachyonychia, but many cases often remain idiopathic. Nail biopsy findings may match skin histology, but more commonly show spongiotic or nonspecific changes. We present an interesting case of a female with progressive development of trachyonychia in all 20 nails coinciding with a new diagnosis of sarcoidosis.
authors.affiliation: Columbia University, Department of Dermatology, New York, NY 10032, USA.
authors.forename: Fiona P
authors.initials: FP
authors.lastname: Blanco
authors.forename: Richard K
authors.initials: RK
authors.lastname: Scher
mesh_terms: D001707:Biopsy, Needle; D003879:Dermatologic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000175:diagnosis / Q000188:drug therapy; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009260:Nail Diseases / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy; D012720:Severity of Illness Index
chemical_list: D003879:Dermatologic Agents