title: IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.
abstract: Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8+ lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4+ and CD8+ lymphocytes along with a decrease in the percentage of CD4+ T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.
authors.affiliation: Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA. sar@nih.gov
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rosenberg
authors.forename: Claude
authors.initials: C
authors.lastname: Sportès
authors.forename: Mojgan
authors.initials: M
authors.lastname: Ahmadzadeh
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Fry
authors.forename: Lien T
authors.initials: LT
authors.lastname: Ngo
authors.forename: Susan L
authors.initials: SL
authors.lastname: Schwarz
authors.forename: Maryalice
authors.initials: M
authors.lastname: Stetler-Stevenson
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Morton
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Mavroukakis
authors.forename: Michel
authors.initials: M
authors.lastname: Morre
authors.forename: Renaud
authors.initials: R
authors.lastname: Buffet
authors.forename: Crystal L
authors.initials: CL
authors.lastname: Mackall
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gress
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D015851:Interleukin-7 / Q000378:metabolism*; D038041:Lymphopoiesis / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000378:metabolism*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D015851:Interleukin-7