title: [Coeliac disease an spastic paraplegia].
abstract: BACKGROUND
  Celiac disease (CD) is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. Neurological manifestations are rare and severe and must be sought systematically.
  
  
  METHODS
  Two non related patients each from a consanguineous marriage developed progressive spastic paraplegia 2 and 8 years respectively after onset of CD. The radiological and biological findings were normal except for the presence of abnormalities related to CD.
  
  
  CONCLUSIONS
  The relationship between spastic paraplegia and CD is not well established. Autoimmune, metabolic and genetic mechanisms could be considered but the probability of a fortuitous association should not be ruled out.
authors.affiliation: Service de Neurologie, CHU, Monastir, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Frih-Ayed
authors.forename: A
authors.initials: A
authors.lastname: Boughammoura-Bouatay
authors.forename: F
authors.initials: F
authors.lastname: Fitouri
authors.forename: S
authors.initials: S
authors.lastname: Chebel
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D002446:Celiac Disease / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005983:Glutens / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009187:Myelitis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D009460:Neurologic Examination; D010264:Paraplegia / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D013116:Spinal Cord / Q000473:pathology
chemical_list: D005983:Glutens