Mouse models for human head and neck squamous cell carcinomas.
Mouse models of human cancer play an important role in understanding the mechanisms of carcinogenesis and have accelerated the search for finding new molecular targets for cancer therapy. However, genetically engineered mouse models for head and neck squamous cell carcinoma (HNSCC) have only recently overcome major technical obstacles and begun to be explored. Here we review the current progress in the development of mouse models for human HNSCC, with emphasis on conditional transgenic and knockout mouse models. These new models faithfully recapitulate human HNSCC at both the pathologic and molecular levels. These animal models will not only be useful to define the roles of specific genes in HNSCC development and progression but will also provide a unique tool for developing and testing new therapeutic approaches.
Lu
Shi-Long
SL
Department of Otolaryngology, Oregon Health & Science University, PVMC Building 103-F221, R&D 46, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA. lus@ohsu.edu
Herrington
Heather
H
Wang
Xiao-Jing
XJ
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D066246:ErbB Receptors / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta; D015127:9,10-Dimethyl-1,2-benzanthracene; D066246:ErbB Receptors