title: An examination of 26,168 Hamilton Depression Rating Scale scores administered via interactive voice response across 17 randomized clinical trials.
abstract: This article presents descriptive and psychometric data from 26,168 Hamilton Depression Rating Scale (HAM-D) scores administered via Interactive Voice Response (IVR) in 17 randomized clinical trials sponsored by 6 pharmaceutical companies. To provide evidence for construct validity, the IVR HAM-D scores before and after randomization are compared, and the change in the IVR HAM-D scores over time after randomization are examined. In addition, the evidence for the reliability of the IVR-administered HAM-D is presented. An examination of the distribution of first-time IVR HAM-Ds before randomization may provide useful information to researchers planning to use the IVR HAM-D as a screening tool for entry or to verify baseline severity in randomized clinical trials.
authors.affiliation: Healthcare Technology Systems, Inc. Madison, WI 53717, USA. hmoore@healthtechsys.com
authors.forename: Heidi K
authors.initials: HK
authors.lastname: Moore
authors.forename: James C
authors.initials: JC
authors.lastname: Mundt
authors.forename: Jack G
authors.initials: JG
authors.lastname: Modell
authors.forename: Heidi E
authors.initials: HE
authors.lastname: Rodrigues
authors.forename: David J
authors.initials: DJ
authors.lastname: DeBrota
authors.forename: James J
authors.initials: JJ
authors.lastname: Jefferson
authors.forename: John H
authors.initials: JH
authors.lastname: Greist
mesh_terms: D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D007398:Interpersonal Relations; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D014831:Voice / Q000187:drug effects*