title: The neurosecretory system is hypertrophied in senescence-accelerated mice.
abstract: The hypothalamic supraoptic and paraventricular nuclei form the neurosecretory system and synthesize the neurohormones oxytocin and arginine-vasopressin. The senescence-accelerated mouse is a model of rapid aging that displays senile amyloidosis and memory problems. This paper presents the characterization of the neurosecretory system and describes the presence of a bilateral constant cluster of neurosecretory neurons in these mice. The stereologic analysis revealed that these groups contain 197 +/- 18 cells (87% synthesize arginine-vasopressin and 13% oxytocin). The presence of these clusters of neurosecretory neurons suggests that these mice could present greater neurohormone synthesis, increasing the deleterious effects of accelerated aging in this strain.
authors.affiliation: Biogerontology Unit, Department of Anatomy and Cell Biology, Faculty of Medicine, University of Cantabria, Santander, Spain. crespod@unican.es
authors.forename: Damaso
authors.initials: D
authors.lastname: Crespo
authors.forename: Manuel
authors.initials: M
authors.lastname: Megias
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernandez-Viadero
authors.forename: Laura
authors.initials: L
authors.lastname: Alonso
authors.forename: Rosario
authors.initials: R
authors.lastname: Verduga
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D006984:Hypertrophy; D007032:Hypothalamus, Anterior / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D051379:Mice; D023421:Models, Animal; D009474:Neurons / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism / Q000473:pathology*