title: Recent advances in clarifying prion protein functions using knockout mice and derived cell lines.
abstract: Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrP(C)), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.
authors.affiliation: Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Akikazu
authors.initials: A
authors.lastname: Sakudo
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Suganuma
authors.forename: Takanori
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Saeki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002460:Cell Line; D018390:Gene Targeting; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism; D011328:Prions / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation
chemical_list: D011328:Prions