title: Salivary interleukin-6 and tumor necrosis factor-alpha in patients with burning mouth syndrome.
abstract: Burning mouth syndrome (BMS) is characterized by burning symptoms on the clinically healthy oral mucosa. To date, etiology of BMS is still unknown. We hypothesized that maybe inflammation which is not clinically apparent might lead to burning symptoms which would then result in altered cytokine profile. In the 28 female patients with BMS (age range 48-80 years, mean 64.05 years) and 28 female controls (age range 40-75 years, mean 63.82 years) by use of enzyme-linked immunosorbent assay, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels were determined. Statistical analysis included use of independent sample t-test and P < 0.05 was considered as significant. Our results show no significant differences between patients and controls regarding salivary IL-6 and TNF-alpha.
authors.forename: V Vucićević
authors.initials: VV
authors.lastname: Boras
authors.forename: V
authors.initials: V
authors.lastname: Brailo
authors.forename: J
authors.initials: J
authors.lastname: Lukac
authors.forename: D
authors.initials: D
authors.lastname: Kordić
authors.forename: Z
authors.initials: Z
authors.lastname: Blazić-Potocki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002054:Burning Mouth Syndrome / Q000209:etiology / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D008875:Middle Aged; D020078:Neurogenic Inflammation / Q000150:complications; D012463:Saliva / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha