[Plasmid elimination effect of usnic acid on antibiotic-resistant Staphylococcus aureus].
OBJECTIVE
To observe the influence of Usnic acid on the antibiotic-resistant plasmid in Staphylococcus aureus (Sa).


METHODS
The antibiotic-resistant plasmid was abstracted from the clinical divided strain of Sa and plasmid elimination test was performed in vitro.


RESULTS
Plasmid elimination test showed that Usnic acid could eliminate the resistant plasmid in Sa effectively. At 24th and 48th hour after the treatment of Usnic acid, the elimination rate of resistant plasmid was 5.2% and 16.4% respectively.


CONCLUSIONS
Usnic acid can eliminate the antibiotic-resistant plasmid in Sa. It is possible to use Usnic acid to treat the infection of antibiotic-resistant Sa in clinic.
Wang
Xiao-Ping
XP
College of Stomatology, Tongji University, Shanghai 200072, China. wxp990@hotmail.com
Liu
Hai-Jiang
HJ
Zhen
Lei
L
Zhou
Zeng-Tong
ZT
Li
Ming-Yu
MY
Zhang
Wei-Dong
WD
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004587:Electrophoresis, Agar Gel; D011815:R Factors / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001572:Benzofurans; C073339:usnic acid