Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes.
Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.
Paulsson
K
K
Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden. kajsa.paulsson@med.lu.se
Johansson
B
B
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002898:Chromosomes, Human, Pair 8; D003043:Cocarcinogenesis; D005260:Female; D018628:Gene Dosage; D052138:Genes, Neoplasm; D018392:Genomic Imprinting; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000648:ultrastructure; D011379:Prognosis; D014314:Trisomy