[Effect of polygonum multiflorum thunb on BDNF expression in rat hippocampus induced by amyloid beta-protein (Abeta) 1-40].
OBJECTIVE
To explore the effect of polygonum multiflorum thunb (PMT) on the expression of brain-drived neurtrophic factor (BDNF) in hippocampus CA1 in rats induced by Abeta1-40.


METHODS
The rat model was established by injecting Abeta1-40 into the right dorsal hippocampus in rats, and their behavior was observed by Y-maze. The morphological changes of rat hippocampus were examined by the Nissl staining. The expression of BDNF in hippocampus CA1 neurons was also examined by immunohistochemistry and Western blot.


RESULTS
After the administration of Abeta1-40, the times of rats learning how to elude electric stimulation were significantly increased, and the expression of BDNF in hippocampus CA1 were obviously reduced. The aggregation of Abeta1-40 in hippocampus and the morphological changes of CA1 hippocampus were found. After the treatment with PMT for 30 days, the times learning how to elude electric stimulation were obviously reduced, while the expression of BDNF in hippocampus CA1 was also increased.


CONCLUSIONS
PMT can reverse the down-regulation of BDNF expression in hippocampus CA1 induced by Abeta1-40.
Qiu
Guang
G
Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, China.
Wu
Xiao-qiong
XQ
Luo
Xue-gang
XG
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D007858:Learning / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D028502:Polygonum; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D019208:Brain-Derived Neurotrophic Factor; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)