[Study on effect of lead exposure to blood lead level and hearing in young offspring through gestation-rat].
OBJECTIVE
To study the effect of lead exposure to the blood lead level and the hearing in young offspring through gestation-rat.


METHODS
Experiments were carried out on 42 Wistar rats, half female and half male, randomly divided into five couple groups (A, B, C, D, E). The group A, as a normal control group, was fed with a standard diet. The group B, C, D and E were fed with a standard diet, additionally with 0.03%, 0.090%, 0.27% and 0.81% lead acetate added respectively, and then fed with standard diet after birth. DPOAE, ABR and blood lead measurement were conducted on the parents rats and the neonatal offspring rats at first week and at the third week respectively.


RESULTS
The blood lead level of neonatal rat reported positively related with that of the parent rats (r = 0. 5817). DPOAE test result: Both parent rats and neonatal rats presented a normal cochlea feedback curve. ABR test result: The period of the group D showed a significant difference from that of the normal control group A. Reaction threshold (dBpeSPL) of the neonatal rat group cl (at the first week) and group c3 (at the third week) showed a notable difference from that of the normal control group al and a3 (c >a).


CONCLUSIONS
The blood lead level of a fetus rat is related with the exposure degree to lead during the pregnant period of mother rat. Low level lead exposure inside uterus during pregnant period will result easily in damage on the hearing nerve center segment and hearing conduct of a fetus rat for they are very sensitive.
Zhao
Shengquan
S
Department of Otolaryngology, Children's Hospital of Kunming, Kunming, 560034, China.
Ma
Yueming
Y
Ni
Linxian
L
Zhang
Jianying
J
Zhang
Tiesong
T
Gao
Yingqing
Y
Zhou
Jingjing
J
D000818:Animals; D005260:Female; D006309:Hearing; D006320:Hearing Tests; D007854:Lead / Q000097:blood*; D008297:Male; D018811:Maternal Exposure; D018812:Paternal Exposure; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D007854:Lead