[Fluorescence detection of photosensitizer photoditazin in the tissue of benign prostatic hyperplasia].
The authors present pilot experience in investigation of accumulation, distribution and elimination of photosensitizer photoditazin from hyperplastic tissue of human prostate. Fluorescent spectroscopy showed that 2-24 hours after intravenous injection of photoditazin in a dose 1 mg/kg, it is detected in hyperplastic tissue of human prostate with maximal accumulation 3 hours after introduction. Exogenic fluorescence of photoditazin lowered 12 and 24 hours after injection this indicating its elimination. The results favor use of photoditazin for photodynamic treatment of patients with benign prostatic hyperplasia.
Iagudaev
D M
DM
Bulgakova
N N
NN
Sorokatyĭ
A E
AE
Geĭnits
A V
AV
Markova
M V
MV
Martov
A G
AG
D005944:Glucosamine / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D017319:Photosensitizing Agents / Q000032:analysis / Q000493:pharmacokinetics*; D011467:Prostate / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*
D017319:Photosensitizing Agents; C047635:N-methylglucosamine; D005944:Glucosamine