White matter changes associated with psychotic symptoms in Alzheimer's disease patients.
This study explored the relationship between white matter changes seen on magnetic resonance imaging (MRI) and neuropsychiatric symptoms of Alzheimer's disease patients. Fifty-five probable Alzheimer's disease patients were assessed with Behavioral Rating Scale for Dementia (BRSD) and MRI. White matter changes in the bilateral frontal or parieto-occipital region and left basal ganglia significantly corresponded with the score of the Psychotic Symptoms subscale of BRSD. Secondary analyses revealed that white matter changes were not associated with paranoid delusion and hallucination, but only with delusional misidentification. Our results suggest that white matter changes in Alzheimer's disease patients probably contribute to the development of specific psychotic symptoms, namely delusional misidentification.
Lee
Dong Young
DY
Department of Neuropsychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.
Choo
Il Han
IH
Kim
Ki Woong
KW
Jhoo
Jin Hyeong
JH
Youn
Jong Choul
JC
Lee
Un Young
UY
Woo
Jong Inn
JI
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002194:Capgras Syndrome / Q000175:diagnosis / Q000523:psychology; D002540:Cerebral Cortex / Q000473:pathology; D003702:Delusions / Q000175:diagnosis / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology