title: Prognostic factors of phyllodes tumor of the breast.
abstract: The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize. The purpose of the present paper was to assess the prognostic value of clinical-morphological characteristics in patients with phyllodes tumor. Forty-seven cases of phyllodes tumors was studied; the World Health Organization classification was used and follow up was obtained. A total of 51%, 28% and 21% of the tumors were classified as benign, borderline and malignant, respectively. The adherence (P = 0.01), size >10 cm (P = 0.001), high mitotic activity (P = 0.03), infiltrative tumor margin (P = 0.0002) and type of surgery in malignant tumors (P = 0.02) proved to be good predictors of relapse. The presence of pain (P = 0.03), postmenopausal status (P < 0.04), heavy cellular pleomorphism (P = 0.007), high mitotic activity (P = 0.002), tumoral grade (P = 0.006) and metastasis (P < 0.00001) were prognostic factors of poor survival. Tumoral grade and some clinical-morphological characteristics of patients with phyllodes tumors have a significant impact on the prediction of its biological behavior.
authors.affiliation: Department of Pathology, Universidad de la Frontera, Temuco, Chile. jcroa@ufro.cl
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Roa
authors.forename: Oscar
authors.initials: O
authors.lastname: Tapia
authors.forename: Paula
authors.initials: P
authors.lastname: Carrasco
authors.forename: Enrique
authors.initials: E
authors.lastname: Contreras
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Araya
authors.forename: Sergio
authors.initials: S
authors.lastname: Muñoz
authors.forename: Iván
authors.initials: I
authors.lastname: Roa
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008593:Menopause; D008938:Mitosis; D003557:Phyllodes Tumor / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate