title: The effect of a worksite based walking programme on cardiovascular risk in previously sedentary civil servants [NCT00284479].
abstract: BACKGROUND
  A significant proportion of Europeans do not meet the recommendations for 30 mins of physical activity 5 times per week. Whether lower frequency, moderate intensity exercise alters cardiovascular disease (CVD) risk has received little attention. This study examined the effects of 45 minutes self-paced walking, 2 d. wk(-1) on aerobic fitness, blood pressure (BP), body composition, lipids and C-Reactive Protein (CRP) in previously sedentary civil servants.
  
  
  METHODS
  37 subjects (24 women) aged 41.5 +/- 9.3 years were randomly assigned to either two 45 minute walks per week (walking group) or no training (control group). Aerobic fitness, body composition, blood pressure (BP), CRP and lipoprotein variables were measured at baseline and following 8 weeks. Steps counts were measured at baseline and during weeks 4 and 8 of the intervention.
  
  
  RESULTS
  Compared to the control group, the walking group showed a significant reduction in systolic BP and maintained body fat levels (P < 0.05). There were no changes other risk factors. Subjects took significantly more steps on the days when prescribed walking was performed (9303 +/- 2665) compared to rest days (5803 +/- 2749; P < 0.001).
  
  
  CONCLUSIONS
  These findings suggest that walking twice per week for 45 minutes at approximately 62% HRmax, improves activity levels, reduces systolic BP and prevents an increase in body fat in previously sedentary adults. This walking prescription, however, failed to induce significant improvements in other markers of cardiovascular disease risk following eight weeks of training.
authors.affiliation: Sport and Exercise Sciences Research Institute, University of Ulster, Northern Ireland, UK. mh.murphy@ulster.ac.uk
authors.forename: Marie H
authors.initials: MH
authors.lastname: Murphy
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Murtagh
authors.forename: Colin Ag
authors.initials: CA
authors.lastname: Boreham
authors.forename: Lesley G
authors.initials: LG
authors.lastname: Hare
authors.forename: Alan M
authors.initials: AM
authors.lastname: Nevill
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001823:Body Composition / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005060:Europe; D005260:Female; D006077:Government Agencies; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D010809:Physical Fitness / Q000502:physiology*; D016138:Walking / Q000502:physiology*; D017132:Workplace
chemical_list: D008074:Lipoproteins; D002097:C-Reactive Protein