title: Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior.
abstract: Previous research has suggested that cholinergic neurons in the nucleus basalis magnocellularis and substantia innominata (NBM/SI) may be important in mediating aversive states. The authors investigated the effect of NBM/SI cholinergic lesions, induced with 192 IgG saporin, on behavioral measures of aversive states in rats. Behavior in the elevated plus maze and behavioral suppression induced by 2 fear-conditioned stimuli, a tone and a light, were evaluated. Lesions had no effect on any measures in the elevated plus maze but attenuated operant suppression induced by the light and attenuated freezing induced by the tone, though this last effect was not statistically significant. The results of the study suggest that NBM/SI cholinergic neurons may be important in mediating selective aspects of aversive states.
authors.affiliation: Department of Psychology, Ohio State University, Columbus, OH, USA. dayank@med.umich.edu
authors.forename: Dayan
authors.initials: D
authors.lastname: Knox
authors.forename: Gary G
authors.initials: GG
authors.lastname: Berntson
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000633:toxicity; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D020532:Basal Nucleus of Meynert / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D018678:Cholinergic Agents / Q000633:toxicity; D002799:Cholinergic Fibers / Q000473:pathology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D005239:Fear; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects / Q000502:physiology; D006651:Histocytochemistry / Q000379:methods; D000922:Immunotoxins / Q000633:toxicity; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009699:N-Glycosyl Hydrolases; D051381:Rats; D017207:Rats, Sprague-Dawley; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D013377:Substantia Innominata / Q000293:injuries / Q000473:pathology / Q000503:physiopathology
chemical_list: C085696:192 IgG-saporin; D000911:Antibodies, Monoclonal; D018678:Cholinergic Agents; D000922:Immunotoxins; D054789:Ribosome Inactivating Proteins, Type 1; D009699:N-Glycosyl Hydrolases; D000076985:Saporins