title: CYLD in ubiquitin signaling and tumor pathogenesis.
abstract: Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-kappaB and activates transcription of proliferation genes in response to growth signals.
authors.affiliation: Institute for Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany.
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Ikeda
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D000081242:B-Cell Lymphoma 3 Protein; D000074749:Deubiquitinating Enzyme CYLD; D016147:Genes, Tumor Suppressor; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD