[Effects and mechanism of total saponins of Psammosilene tunicoids against rheumatoid arthritis].
OBJECTIVE
To observe the antiarthritic effects and the possible mechanism of total saponins of Psammruosilene tunicoids (TSPT) against rheumatoid arthritis (RA).


METHODS
After establishing AA rat model, the TSPT'S antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, arthritis index and levels of IL-1beta and TNF-alpha after medication.


RESULTS
TSPT could effectively inhibits articular swelling, decrease arthritis index and regulate down the content of IL-1beta and TNF-alpha in the inflammatory tissue soak of AA rats.


CONCLUSIONS
TSPT has good antiarthritic effects and the possible mechanism may be related to its down-regulation of IL-1beta and TNF-alpha.
Wang
Xue-yong
XY
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing. wxyfresh@sohu.com
Zhang
Yuan
Y
Xu
Jian-yang
JY
Qiu
De-wen
DW
Huang
Lu-qi
LQ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology; D029748:Caryophyllaceae / Q000737:chemistry; D005528:Foot / Q000473:pathology; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007375:Interleukin-1; D012503:Saponins; D014409:Tumor Necrosis Factor-alpha