title: p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
abstract: Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53 had fewer tumors than p53+/- mice. The rare tumors that developed in mice with compromised p63 were also distinct from those of p53+/- mice. Furthermore, p63+/- mice were not prone to chemically induced tumorigenesis, and p63 expression was maintained in carcinomas. These findings demonstrate that, in agreement with data from human tumors, p63 plays a markedly different biological role in cancer than p53.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Keyes
authors.forename: Hannes
authors.initials: H
authors.lastname: Vogel
authors.forename: Maranke I
authors.initials: MI
authors.lastname: Koster
authors.forename: Xuecui
authors.initials: X
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Qi
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Petherbridge
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Roop
authors.forename: Allan
authors.initials: A
authors.lastname: Bradley
authors.forename: Alea A
authors.initials: AA
authors.lastname: Mills
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D004198:Disease Susceptibility; D015972:Gene Expression Regulation, Neoplastic; D042822:Genomic Instability / Q000235:genetics; D006579:Heterozygote; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010750:Phosphoproteins / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D015534:Trans-Activators / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse