Expression of the dopamine transporter in rat and bullfrog retinas.
We examined the expression of the dopamine transporter in rat and bullfrog retinas by immunohistochemistry. In both species, the dopamine transporter was strongly expressed in somata and processes of all dopaminergic amacrine cells. In contrast, no immunoreactivity for dopamine transporter was observed in cholinergic amacrine cells. In rat dopaminergic interplexiform cells, dopamine transporter immunoreactivity was also observed on the ascending processes terminating in the outer plexiform layer. Furthermore, the labeling for dopamine transporter diffusely appeared in both outer and inner plexiform layers. This expression profile of the dopamine transporter suggests that dopamine may be taken up not only in the synapses but also extrasynaptically by dopamine transporter, diffusely distributed in both plexiform layers.
Cheng
Zhe
Z
Institute of Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China.
Zhong
Yong-Mei
YM
Yang
Xiong-Li
XL
D025042:Amacrine Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001369:Axons / Q000378:metabolism / Q000648:ultrastructure; D003712:Dendrites / Q000378:metabolism / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D018613:Microscopy, Confocal; D011892:Rana catesbeiana / Q000033:anatomy & histology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000033:anatomy & histology / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D013045:Species Specificity; D013347:Subcellular Fractions; D009435:Synaptic Transmission / Q000502:physiology
D050483:Dopamine Plasma Membrane Transport Proteins; D004298:Dopamine