title: Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity.
abstract: High-sensitivity C-reactive protein (hs-CRP) is associated with an increased risk of cardiovascular disease and the development of type 2 diabetes mellitus. We analyzed the effects of lifestyle modifications including exercise training on hs-CRP in 47 overweight and obese adults. Subjects were divided into a lifestyle modification group (n=23) (exercise and diet instruction) and a control group (n=24) who did not participate in any lifestyle modification. After 3 months, body weight (80.8+/-11.5 to 73.5+/-10.7 kg, P<.01), total cholesterol (217+/-38.4 to 178.0+/-25.6 mg/dL, P<.01), low-density lipoprotein cholesterol (151.3+/-34.9 to 116.7+/-27.8 mg/dL, P<.01), Vo(2)peak (30.3+/-5.1 to 37.1+/-6.9 mL/[kg . min], P<.01), and log hs-CRP (0.75+/-0.4 to 0.56+/-0.3 mg/dL, P=.01) were significantly improved in the lifestyle modification group, but there was no significant improvement in the control group. Changes in log hs-CRP were associated with changes in Vo(2)peak (r=-0.41, P=.004) and changes in weight loss (r=0.42, P=.004). In stepwise multiple regression analysis, weight loss (P=.034) and improved Vo(2)peak (P=.039) were independent predictors of the changes in hs-CRP. When grouped into quartiles according to decreasing weight and increasing Vo(2)peak, levels of changes in log hs-CRP improved across quartiles of weight loss (P<.05) and improved Vo(2)peak (P<.01). Thus, lifestyle changes including regular exercise training in overweight and obese adults decreased hs-CRP, and this was associated with weight loss and improved Vo(2)peak.
authors.affiliation: Exercise and Cardiovascular Research Lab, Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL 61820, USA.
authors.forename: Sae Young
authors.initials: SY
authors.lastname: Jae
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Heffernan
authors.forename: Mihye
authors.initials: M
authors.lastname: Jeong
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Chun
authors.forename: Jidong
authors.initials: J
authors.lastname: Sung
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Lim
authors.forename: Won Hah
authors.initials: WH
authors.lastname: Park
mesh_terms: D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D002097:C-Reactive Protein / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040242:Risk Reduction Behavior; D015431:Weight Loss
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol