Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention.
This study was aimed to investigate the effect of sedation on plasma soluble P-selectin (sP-selectin) levels and initiation phase of coagulation following coronary intervention. A total of 58 patients with unstable angina were randomised into two groups of sedated (n = 29) and nonsedated (n = 29) patients. sP-Selectin, adrenaline, noradrenaline, von Willebrand factor (vWF), fibrinogen, platelet and troponin-I levels were measured before the intervention and at 30 min and 24 h after the intervention. In the sedated group, adrenaline, noradrenaline, sP-selectin and fibrinogen levels remained stable 30 min after the intervention (p > 0.05), whereas vWF level increased (p < 0.05). In the nonsedated group, 30-min sP-selectin (p < 0.001), adrenaline (p < 0.05), noradrenaline (p = 0.012), vWF (p < 0.001) and fibrinogen (p < 0.001) levels were found to be increased. Also, 24-h sP-selectin, vWF and fibrinogen levels for both groups showed significant increases when compared with the values both 30 h before (p < 0.001) and 30 min after the intervention (p < 0.001). Sedation before interventions reduces sP-selectin levels, initial phase of coagulation and, consequently, myocardial damage.
Yazici
M
M
Ondokuz Mayis University Medical Faculty, Department of Cardiology and Microbiology and Clinical Microbiology, Samsun, Turkey. drmeyaz@hotmail.com
Demircan
S
S
Aygul
E
E
Sahin
M
M
Albayrak
F
F
Aksakal
E
E
Durupinar
B
B
Zimmo
A
A
Sagkan
O
O
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects*; D009202:Cardiomyopathies / Q000517:prevention & control*; D016292:Procedural Sedation; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood* / Q000187:drug effects; D015607:Stents
D015415:Biomarkers; D006993:Hypnotics and Sedatives; D019007:P-Selectin; D008874:Midazolam