title: Modifications in the production of cytokines and growth factors in drainage fluids following mesh implantation after incisional hernia repair.
abstract: BACKGROUND
  The aim of this study was to evaluate changes in the production of some cytokines (interleukins [ILs]-6, -10, -1, and -1ra), vascular endothelial growth factor, and beta-fibroblast growth factor after polypropylene mesh implantation.
  
  
  METHODS
  Twenty female patients were divided into 2 groups. In 1 group, hernia repair was performed with conventional sutures (CR), whereas in the other group polypropylene mesh (MR) was used. Growth factors and cytokines production was analyzed in wound drain fluids based on the amount produced during 24 hours.
  
  
  RESULTS
  IL-1 increased substantially in MR patients on postoperative days 1 and 2. IL1-ra and IL-10 production was always significantly higher in CR patients. IL-6 production did not show any considerable difference between the 2 groups. Vascular endothelial growth factor production was significantly higher in the MR than the CR group at all time points, whereas beta-fibroblast growth factor production was higher in the MR than the CR group only on postoperative day 1.
  
  
  CONCLUSIONS
  Our data suggest that different surgical procedures induce various levels of inflammation and that implantation of prostheses significantly stimulates the inflammatory response.
authors.affiliation: Surgical and Oncological Science Department, Division of General Surgery, University of Palermo, Palermo, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Di Vita
authors.forename: Rosalia
authors.initials: R
authors.lastname: Patti
authors.forename: Pietro
authors.initials: P
authors.lastname: D'Agostino
authors.forename: Viviana
authors.initials: V
authors.lastname: Ferlazzo
authors.forename: Mariangela
authors.initials: M
authors.lastname: Angileri
authors.forename: Gianluca
authors.initials: G
authors.lastname: Sieli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Buscemi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caruso
authors.forename: Matteo
authors.initials: M
authors.lastname: Arcara
authors.forename: Enrico
authors.initials: E
authors.lastname: Cillari
mesh_terms: D000328:Adult; D016207:Cytokines / Q000032:analysis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000378:metabolism*; D007378:Interleukins / Q000032:analysis / Q000378:metabolism; D007813:Laparotomy / Q000379:methods; D008875:Middle Aged; D010149:Postoperative Pain; D011126:Polypropylenes; D011182:Postoperative Care / Q000379:methods; D011446:Prospective Studies; D013526:Surgical Mesh; D013536:Suture Techniques; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007378:Interleukins; D011126:Polypropylenes; D042461:Vascular Endothelial Growth Factor A