[Effect of head hypothermia on serum inflammatory cytokines levels in patients with hypertensive intracerebral hemorrhage].
OBJECTIVE
To study changes in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in hypertensive intracerebral hemorrhage (HIH) and observe the potential effect of head hypothermia.


METHODS
One hundred and twenty four cases of HIH were divided into head hypothermia treatment group (n=63) and control group (n=61) according to treatment with or without head hypothermia. The serum IL-6 and TNF-alpha level in the two groups were determined on the 2nd and 8th days with enzyme linked immunoadsorbent assay (ELISA) and radioimmunoassay, and compared to those of the healthy volunteers (n=40). In addition, the life quality scores of the two groups were compared.


RESULTS
The serum IL-6 and TNF-alpha levels in both head hypothermia treatment group and control group were higher on the 2nd day after hospitalization compared with the healthy controls (all P<0.01), and there was no significant difference in serum IL-6 and TNF-alpha levels on the 2nd day between the head hypothermia treatment group and control group (both >0.05). Serum IL-6 and TNF-alpha levels in the head hypothermia treatment group on the 8th day after hyperthermia were significantly lower than those on the 2nd day after hospitalization (both P<0.05), while the changes of control group was not significant (both >0.05), and significant difference in serum IL-6 and TNF-alpha was found between head hypothermia treatment group and control group on day 8 (both P<0.01). The prognosis quality of life in head hypothermia treatment group was markedly higher than the control group (P<0.05).


CONCLUSIONS
The levels of serum IL-6 and TNF-alpha were increased significantly during early stage of HIH. Head hypothermia can effectively reduce the serum IL-6 and TNF-alpha levels of early HIH patients, and improve the prognosis quality of life as well.
Zhang
Xiao-ming
XM
Department of Neurology, The 159th Hospital of PLA, Zhumadian 463008, Henan, China.
Li
Xin-li
XL
Tang
Shu-hua
SH
Liu
Qun-cai
QC
D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D015850:Interleukin-6 / Q000097:blood*; D020299:Intracranial Hemorrhage, Hypertensive / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha