Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsets.
Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naïve CD8(+) T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases.
Gupta
Sudhir
S
Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA. sgupta@ici.edu
Gollapudi
Sastry
S
D000375:Aging / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008928:Mitochondria / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D019014:fas Receptor / Q000276:immunology
D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor