title: Evaluation of the antibacterial activity and toxicity of 2 new hydrogels: a pilot study.
abstract: Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal and Flaminal Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.
authors.affiliation: Department of Radiopharmacy, Ghent University, Ghent, Belgium.
authors.forename: Katia
authors.initials: K
authors.lastname: Vandenbulcke
authors.forename: Lada-Ivana Laenen
authors.initials: LI
authors.lastname: Horvat
authors.forename: Martine
authors.initials: M
authors.lastname: De Mil
authors.forename: Guido
authors.initials: G
authors.lastname: Slegers
authors.forename: Hilde
authors.initials: H
authors.lastname: Beele
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000464:Alginates / Q000009:adverse effects / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D001424:Bacterial Infections / Q000517:prevention & control*; D047070:Bandages, Hydrocolloid; D004338:Drug Combinations; D005260:Female; D005949:Glucose Oxidase / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000009:adverse effects / Q000494:pharmacology*; D066298:In Vitro Techniques; D015603:Keratinocytes / Q000187:drug effects; D007784:Lactoperoxidase / Q000009:adverse effects / Q000494:pharmacology*; D007871:Leg Ulcer / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D010865:Pilot Projects; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C000612382:Flaminal; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D005949:Glucose Oxidase; D007784:Lactoperoxidase