title: Receiver-operating characteristic analysis of leukocyte counts and serum C-reactive protein levels in children with advanced appendicitis.
abstract: OBJECTIVE
  To assess the diagnostic value of the white blood cell count (WBC) and serum C-reactive protein (CRP) level in children with advanced appendicitis.
  
  
  METHODS
  We reviewed 289 children ranging in age from 3 to 15 years old, who underwent appendectomy in our hospital between 1993 and 2003. The advanced appendicitis group consisted of patients with associated perforation, abscess formation, or purulent ascites, and the simple appendicitis group consisted of patients who underwent uncomplicated appendectomy. We compared the age, sex, duration of abdominal pain before surgery, preoperative WBC and CRP level, and hospital stay in the two groups. We analyzed the diagnostic value of WBC and CRP level using a receiver-operating characteristic (ROC) curve.
  
  
  RESULTS
  The children in the advanced appendicitis group had a significantly longer duration of pain, a higher serum CRP level, and longer hospitalization than those in the simple group. The serum CRP levels had good diagnostic value in differentiating between the advanced and simple groups. Both the CRP level and the WBC in the patients who suffered abdominal pain for longer than 48 h before surgery had diagnostic value in differentiating between the advanced and simple groups.
  
  
  CONCLUSIONS
  These findings suggest that increased values of CRP and WBC more than 48 h after the onset of acute abdominal symptoms are indicators of advanced appendicitis.
authors.affiliation: Department of Pediatric Surgery, Kobe Children's Hospital, 1-1-1 Takakura-dai, Sama-ku, Kobe, 654-0081, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okamoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sano
authors.forename: Keizo
authors.initials: K
authors.lastname: Ogasahara
mesh_terms: D000038:Abscess / Q000097:blood; D000293:Adolescent; D001064:Appendicitis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D001201:Ascites / Q000150:complications; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007902:Length of Stay; D007958:Leukocyte Count; D008297:Male; D010146:Pain; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013492:Suppuration
chemical_list: D002097:C-Reactive Protein