[Anti-inflammatory action of myoinositol in renal insufficiency].
OBJECTIVE
Release of prostaglandin E2 (PGE2) and leukotrien B4 (LTB4) in vitro by resting and PHA-stimulated peripheral blood mononuclear cells (PBMNC) in the presence of three concentrations of myoinositol (30, 300, 600 micromol/l) was investigated.


METHODS
We examinated 10 uremic patients on regular hemodialysis treatment and 10 healthy subjects (control group).


RESULTS
Release of PGE2 and LTB4 by resting and PHA-stimulated PBMNC was significantly lower in the presence of myoinositol in concentrations generally obserwed in the blood serum of chronic uraemic patients on regular hemodialysis treatment (600 micromol/l) in both investigated groups, while it remained unchanged in the presence of myoinositol in the concentration observed in normal blood serum (30 micromol/l).


CONCLUSIONS
The results seem to indicate that myoinositol, in the concentrations found in uremic blood serum, may possibly exert antiinflammatory actions.
Rysz
Jacek
J
Uniwersytet Medyczny w Lodzi, Uniwersytecki Szpital Kliniczny Nr 2. rb72@interia.pl
Bartnicki
Piotr
P
Błaszczak
Robert
R
Kujawski
Krzysztof
K
Ciałkowska-Rysz
Aleksandra
A
Olszewski
Robert
R
Markuszewski
Leszek
L
D000328:Adult; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D014511:Uremia / Q000150:complications / Q000378:metabolism
D007975:Leukotriene B4; D007294:Inositol; D015232:Dinoprostone