title: Analgesic activity of leaf extracts of Culcasia scandens P. Beauv.
abstract: Analgesic activity of methanol leaf extract of C. scandens obtained by column chromatography and its graded solvent fractions, was evaluated in mice using acetic acid-induced abdominal writhing and formalin-induced paw licking. The extract and fractions significantly inhibited abdominal writhing and two phases of formalin-induced paw licking in mice, indicating that antinociceptive activity may involve inhibition of pain by peripheral and central mechanisms.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka Enugu State, Nigeria. charlesokoli@hotmail.com
authors.forename: C O
authors.initials: CO
authors.lastname: Okoli
authors.forename: P A
authors.initials: PA
authors.lastname: Akah
authors.forename: O N
authors.initials: ON
authors.lastname: Egbuniwe
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D029064:Araceae / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000700:Analgesics; D010936:Plant Extracts