title: Aprotinin in the management of coagulopathy associated with amniotic fluid embolus.
abstract: Amniotic fluid embolus, also known as anaphylactoid syndrome of pregnancy is a rare complication of pregnancy. When it occurs, the maternal mortality rate may be as high as 86%, and in survivors, the morbidity rate may be just as high. Hallmark clinical features include maternal cardiovascular collapse with disseminated intravascular coagulation, and fetal distress. Management centers on strategies to improve oxygenation, support circulation, and correct the coagulopathy. We report the case of a patient who developed amniotic fluid embolus and was effectively managed with aprotinin to control the coagulopathy associated with this devastating complication of pregnancy.
authors.affiliation: University of Oklahoma College of Pharamcy, Tulsa, 74135, USA. Jeffrey-Stroup@ouhsc.edu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Stroup
authors.forename: Davin
authors.initials: D
authors.lastname: Haraway
authors.forename: J Martin
authors.initials: JM
authors.lastname: Beal
mesh_terms: D000328:Adult; D007611:Aprotinin / Q000627:therapeutic use*; D001772:Blood Cell Count; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology*; D001780:Blood Coagulation Tests; D000077324:Crystalloid Solutions; D004619:Embolism, Amniotic Fluid / Q000503:physiopathology*; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000627:therapeutic use; D011247:Pregnancy; D014599:Uterus / Q000503:physiopathology
chemical_list: D000077324:Crystalloid Solutions; D006490:Hemostatics; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D007611:Aprotinin