The exosome and the proteasome: nano-compartments for degradation.
Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.
Lorentzen
Esben
E
European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
Conti
Elena
E
D001665:Binding Sites; D005095:Exoribonucleases / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D013379:Substrate Specificity
D046911:Macromolecular Substances; D021122:Protein Subunits; D012313:RNA; D005095:Exoribonucleases; D046988:Proteasome Endopeptidase Complex