[Effects of methylergometrine and oxytocin on blood loss and uterine contraction during cesarean section].
BACKGROUND
The effects of intravenous oxytocics on blood loss and uterine contraction during cesarean section were studied in 136 parturients.


METHODS
The subjects were randomized to receive either methylergometrine 0.2 mg bolus (MEM group; n = 34), oxytocin 10 IU over 30 seconds (OX 30 s group; n = 34), oxytocin 10 IU over 5 minutes (OX 5 m group; n = 34) or oxytocin 10 IU over 15 minutes (OX 15 m group; n = 34). The subjects received spinal anesthesia with 11-12 mg of intrathecal isobaric bupivacaine (0.5%). Additional intramyometrial prostaglandin F2alpha (PGF2alpha) was administered when obstetrician diagnosed uterine atony. We analyzed total amount of blood loss including amniotic fluid and number of parturients that received additional intramyometrial PGF2alpha to evaluate uterine contraction.


RESULTS
The amounts of blood loss in the OX 30 s and OX 5 m groups were significantly lower than in the MEM group, and the numbers of parturients received additional PGF2alpha in all the oxytocin treat ment groups were significantly lower than in the MEM group (P < 0.05). There were no significant differences in blood loss and uterine contractior among the oxytocin treatment groups.


CONCLUSIONS
Intravenous oxytocin 10 IU over 30 seconds to 15 minutes was effective to decrease blood loss and uterine contraction than intravenous methylergometrine 0.2 mg bolus.
Kikutani
Takehiko
T
Division of Anesthesia, Nippon Medical School Second Hospital, Kawasaki 211-8533.
Kikutani
Mariko
M
Oshima
Masayuki
M
Sugimoto
Kikuzou
K
Shimada
Yoichi
Y
D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D016063:Blood Loss, Surgical; D002585:Cesarean Section; D005260:Female; D006801:Humans; D008755:Methylergonovine / Q000494:pharmacology*; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D010120:Oxytocics; D010121:Oxytocin; D008755:Methylergonovine