title: The role of ras gene in the development of haemic neoplasia in Mytilus trossulus.
abstract: Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression.
authors.affiliation: Department of Biology and Environmental Science, Centre for Environmental Research, University of Sussex, Falmer, Brighton BN1 9QJ, UK.
authors.forename: Corina M
authors.initials: CM
authors.lastname: Ciocan
authors.forename: James D
authors.initials: JD
authors.lastname: Moore
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Rotchell
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D017931:DNA Primers / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D011905:Genes, ras / Q000235:genetics / Q000502:physiology*; D006434:Hemocytes / Q000473:pathology; D008969:Molecular Sequence Data; D049878:Mytilus / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D018807:Polymorphism, Single-Stranded Conformational; D012337:RNA, Ribosomal, 18S / Q000235:genetics
chemical_list: D017931:DNA Primers; D012337:RNA, Ribosomal, 18S