Liver PPARalpha and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice.
Swim training for 6 weeks significantly decreased body weight gain, adipose tissue mass, and adipocyte size in both sexes of genetically obese db/db mice compared with their respective sedentary controls. Swim training also caused significant decreases in serum levels of free fatty acids, triglycerides, and total cholesterol in both sexes of obese mice. Concomitantly, hepatic mRNA levels of peroxisome proliferator-activated receptor alpha (PPARalpha) target enzymes responsible for mitochondrial and peroxisomal fatty acid beta-oxidation were significantly increased by swim training. Moreover, mRNA levels of uncoupling protein 2 (UCP2) in liver were also markedly increased by swim training. In conclusion, these results suggest that swim training-induced transcriptional activation of hepatic PPARalpha target enzymes and UCP2 may effectively prevent body weight gain, adiposity, and lipid disorders caused by leptin receptor deficiency in both sexes of mice.
Oh
Ki Sook
KS
Department of Physical Education, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
Kim
Mina
M
Lee
Jinmi
J
Kim
Min Jeong
MJ
Nam
Youn Shin
YS
Ham
Jung Eun
JE
Shin
Soon Shik
SS
Lee
Chung Moo
CM
Yoon
Michung
M
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D005260:Female; D007473:Ion Channels; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D026901:Membrane Transport Proteins / Q000378:metabolism*; D051379:Mice; D008820:Mice, Obese; D008822:Mice, Transgenic; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009765:Obesity / Q000473:pathology*; D047493:PPAR alpha / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D012737:Sex Factors; D013550:Swimming; D000071246:Uncoupling Protein 2
D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D047493:PPAR alpha; C000604390:Ucp2 protein, mouse; D000071246:Uncoupling Protein 2