Antifungal combination treatment: a future perspective.
The use of antifungal combination therapy is a new clinical approach for combating fungal infections. Although few conclusive clinical studies have been performed to date, data exist that strongly suggest that combination therapy would benefit specific patient subgroups (e.g. stem-cell transplant recipients). This paper examines the evidence available from in vitro, experimental, and clinical studies, and seeks to discover viable clinical strategies for this promising new therapeutic approach.
Fohrer
Cécile
C
Département d'Hématologie et d'Oncologie, Hôpital de Hautepierre, Strasbourg, France.
Fornecker
Luc
L
Nivoix
Yasmine
Y
Cornila
Corina
C
Marinescu
Cristina
C
Herbrecht
Raoul
R
D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy; D000077336:Caspofungin; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005544:Forecasting; D006801:Humans; D066298:In Vitro Techniques; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000009:adverse effects / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000009:adverse effects / Q000627:therapeutic use*
D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin