title: Manganese transport and the role of manganese in virulence.
abstract: Two areas of research have recently converged to highlight important roles for Mn(2+) in pathogenesis: the recognition that both bacterial Nramp homologs and members of LraI family of proteins are Mn(2+) transporters. Their mutation is associated with decreased virulence of various bacterial species. Thus, Mn(2+) appears to be essential for bacterial virulence. This review describes what is currently known about Mn(2+) transport in prokaryotes and how prokaryotic Mn(2+) transport is regulated. Some of the phenotypes that arise when microorganisms lack Mn(2+) are then discussed, with an emphasis on those phenotypes involving pathogenesis. The concluding section describes possible enzymatic roles for Mn(2+) that might help explain why Mn(2+) is necessary for virulence.
authors.affiliation: Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106-4965, USA. krisztina.papp@case.edu
authors.forename: Krisztina M
authors.initials: KM
authors.lastname: Papp-Wallace
authors.forename: Michael E
authors.initials: ME
authors.lastname: Maguire
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D000818:Animals; D001408:Bacillus anthracis / Q000378:metabolism / Q000472:pathogenicity; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000502:physiology; D001692:Biological Transport; D002244:Carbon / Q000378:metabolism; D027682:Cation Transport Proteins / Q000502:physiology; D008345:Manganese / Q000502:physiology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000378:metabolism / Q000472:pathogenicity; D010766:Phosphorylation; D012097:Repressor Proteins / Q000502:physiology; D012486:Salmonella typhimurium / Q000378:metabolism / Q000472:pathogenicity; D013291:Streptococcus / Q000378:metabolism / Q000472:pathogenicity; D014774:Virulence; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D002244:Carbon; D027682:Cation Transport Proteins; D008345:Manganese; D012097:Repressor Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1; C433792:MntR protein, bacteria