title: Subcutaneous fat tissue for diagnosis and studies of systemic amyloidosis.
abstract: The systemic amyloidoses comprise a biochemically heterogeneous group of potentially lethal disorders. An early and precise diagnosis is crucial for the treatment and prognosis. Subcutaneous fat biopsy is a simple and safe method to obtain a diagnosis of systemic amyloidosis and the material can be used for exact determination of amyloid type. A method is described for immunochemical typing of the amyloid based on Western blot analysis combined with specific amyloid fibril protein antibodies.
authors.affiliation: Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. Per.Westermark@genpat.uu.se
authors.forename: Per
authors.initials: P
authors.lastname: Westermark
authors.forename: Eva
authors.initials: E
authors.lastname: Davey
authors.forename: Karolina
authors.initials: K
authors.lastname: Lindbom
authors.forename: Stina
authors.initials: S
authors.lastname: Enqvist
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000032:analysis / Q000145:classification / Q000378:metabolism*; D000686:Amyloidosis / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D001706:Biopsy; D015153:Blotting, Western; D004396:Coloring Agents; D003224:Congo Red; D006801:Humans; D007120:Immunochemistry / Q000379:methods; D040521:Subcutaneous Tissue / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*
chemical_list: D000682:Amyloid; D004396:Coloring Agents; D003224:Congo Red