[Solid neoplasms localised within the parameningeal region and CNS infiltration].
BACKGROUND
Solid neoplasms primarily localised within parameningeal region constitute a significant diagnostic and therapeutic problem. Solid tumours developing in the primary site are soft tissue sarcomas (STS) and lymphoepithelioma.


OBJECTIVE
Evaluation of the incidence of CNS infiltration, histological type of tumour and results of treatment.


METHODS
The study enrolled 14 patients being treated for solid tumours primarily localised within the perimeningeal region, in the Department of Paediatric Haematology and Oncology of the Medical University of Lublin between 1992 and 2004. The age of patients ranged from 2 up to 17 years (mean 8.5): 4 girls and 10 boys.


RESULTS
Soft tissue sarcoma was diagnosed in 10/14 children: rhabdomyosarcoma (RMS) embryonale in 8 patients, RMS alveolare in 1, leiomyosarcoma in 1, and lymphoepithelioma in four children. The stage of disease was III degree in all children (without CNS infiltration). Secondary infiltration of CNS was diagnosed in 2/14 children with STS.


CONCLUSIONS
Secondary CNS infiltration was diagnosed in 2/14 patients. Despite of combined treatment, results of treatment are still poor due to local recurrance with CNS infiltration.
Zawitkowska-Klaczyńska
Joanna
J
Klinika Hematologii i Onkologii Dzieciecej AM w Lublinie. jzawikowska@o2.pl
Nurzyńiska-Flak
Joanna
J
Katski
Krzysztof
K
Kowalczyk
Jerzy R
JR
D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015174:Epidural Neoplasms / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000628:therapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012509:Sarcoma; D013355:Subdural Space; D016019:Survival Analysis; D016896:Treatment Outcome