title: Clinical evaluation of association of bovine organic osseous matrix and bovine bone morphogenetic protein versus autogenous bone graft in sinus floor augmentation.
abstract: OBJECTIVE
  The purpose of the present study is to evaluate clinically and radiographically the behavior of the association between bovine organic osseous matrix (BOM) and bovine bone morphogenetic protein (bBMP) versus autogenous bone graft in promoting bone healing in maxillary sinus lifting procedures.
  
  
  METHODS
  Ten nonsmoking and systemically healthy patients who needed bilateral maxillary sinus grafting for the placement of osseointegrated implants were treated. In all patients, 1 side was selected as test (bBMP + BOM) and the other as control using autogenous particulated bone graft from mandibular ramus. After a period varying from 6 to 11 months, the implants were placed. The radiographic analysis was realized by panoramic-rx. The clinical analysis consisted of transoperative evaluation by visual observation of bone formation of grafted area and initial stability of implants.
  
  
  RESULTS
  Radiographically, the images were evaluated observing radio-opaque aspect. Clinically, a better bone formation pattern of the grafted area in the side grafted with autogenous bone could be observed. The initial stability of the implants in the side grafted with autogenous bone was better than in the test side. The placement torque of the implants in the test side was more than 30 N-cm.
  
  
  CONCLUSIONS
  In the present study, the association of bovine organic osseous matrix and bBMP as a growth factor showed different results when compared with autogenous graft. It was observed in the absence of an radio-opaque image, making it difficult to select the implants. Clinically, the bone formation was partial and showed the presence of the fibrous tissue in the grafted area when using the association of bovine organic osseous matrix and bBMP, and the placement torque of implants was less than the control side.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Piracicaba Dental School, University of Campinas-Unicamp, Piracicaba, Brazil.
authors.forename: Fabrício Moreira
authors.initials: FM
authors.lastname: Serra E Silva
authors.forename: José
authors.initials: J
authors.lastname: Ricardo de Albergaria-Barbosa
authors.forename: Renato
authors.initials: R
authors.lastname: Mazzonetto
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D011862:Radiography, Panoramic; D019415:Torque
chemical_list: D019485:Bone Morphogenetic Proteins