Intracerebroventricular injection of neuropeptide Y modifies carbohydrate and lipid metabolism in chicks.
The purpose of the present study was to investigate whether intracerebroventricular (ICV) injection of neuropeptide Y (NPY) affects heat production (HP), body temperature, and plasma concentrations of metabolic fuels in chicks. ICV injection of NPY (0, 188 or 375 pmol) did not affect HP, but significantly lowered respiratory quotient as well as the rectal temperature. These data suggest that the energy sources for HP were modified by NPY in the body. This idea was confirmed by subsequent experiments in which ICV injection of NPY significantly reduced plasma glucose and triacylglycerol concentrations but increased non-esterified fatty acid concentrations. The effect of NPY on the utilization of metabolic fuels was not associated changes in plasma catecholamine and corticosterone concentrations. In summary, the present study demonstrated that central NPY modifies peripheral carbohydrate and lipid metabolism in chicks.
Tachibana
Tetsuya
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. tetsu@brs.kyushu-u.ac.jp
Sato
Momoka
M
Oikawa
Daichi
D
Takahashi
Hirokazu
H
Boswell
Tim
T
Furuse
Mitsuhiro
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature; D002241:Carbohydrates / Q000737:chemistry*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005227:Fatty Acids / Q000378:metabolism; D006358:Hot Temperature; D007276:Injections, Intraventricular / Q000379:methods; D050356:Lipid Metabolism; D008297:Male; D009478:Neuropeptide Y / Q000008:administration & dosage*; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D001786:Blood Glucose; D002241:Carbohydrates; D005227:Fatty Acids; D009478:Neuropeptide Y; D014280:Triglycerides