[Corticosteroids in giant cell arteritis: primum nil nocere?].
BACKGROUND
Steroids are the treatment of choice for giant cell arteritis but bear the risk of serious side effects.


METHODS
We carried out a retrospective study on 34 patients with documented giant cell arteritis (24 with ocular involvement) by means of a questionnaire sent to the treating physicians.


RESULTS
After a mean follow-up of 48 months, side effects occurred in 90 % of the patients. The most frequent were weight gain (> 50 %) and osteoporosis (> 40 %, F >> M). Side effects were more common in patients with ocular involvement and in women. Severe complications were significantly more frequent in patients with ocular involvement.


CONCLUSIONS
Side effects are the rule and not the exception in the treatment of giant cell arteritis. They can affect quality of life. Physicians should bear them in mind as many are preventable and/or treatable.
Meola
D C
DC
Augenklinik UniversitätsSpital Zürich, Schweiz. carlo.meola@bluewin.ch
Fierz
A
A
Tschopp
A
A
Landau
K
K
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D018917:Optic Neuropathy, Ischemic / Q000209:etiology* / Q000517:prevention & control*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones