title: A tiered approach to systemic toxicity testing for agricultural chemical safety assessment.
abstract: A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA Systemic Toxicity Task Force proposes an approach to systemic toxicity testing as one part of the overall assessment of a compound's potential to cause adverse effects on health. The approach is designed to provide more relevant data for deriving reference doses for shorter time periods of human exposure, and includes fewer studies for deriving longer term reference doses-that is, neither a 12-month dog study nor a mouse carcinogenicity study is recommended. All available data, including toxicokinetics and metabolism data and life stages information, are taken into account. The proposed tiered testing approach has the potential to provide new risk assessment information for shorter human exposure durations while reducing the number of animals used and without compromising the sensitivity of the determination of longer term reference doses.
authors.affiliation: Syngenta CTL, Macclesfield, United Kingdom.
authors.forename: John E
authors.initials: JE
authors.lastname: Doe
authors.forename: Alan R
authors.initials: AR
authors.lastname: Boobis
authors.forename: Ann
authors.initials: A
authors.lastname: Blacker
authors.forename: Vicki
authors.initials: V
authors.lastname: Dellarco
authors.forename: Nancy G
authors.initials: NG
authors.lastname: Doerrer
authors.forename: Claire
authors.initials: C
authors.lastname: Franklin
authors.forename: Jay I
authors.initials: JI
authors.lastname: Goodman
authors.forename: Joel M
authors.initials: JM
authors.lastname: Kronenberg
authors.forename: Richard
authors.initials: R
authors.lastname: Lewis
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Mcconnell
authors.forename: Thierry
authors.initials: T
authors.lastname: Mercier
authors.forename: Angelo
authors.initials: A
authors.lastname: Moretto
authors.forename: Canice
authors.initials: C
authors.lastname: Nolan
authors.forename: Stephanie
authors.initials: S
authors.lastname: Padilla
authors.forename: Whang
authors.initials: W
authors.lastname: Phang
authors.forename: Roland
authors.initials: R
authors.lastname: Solecki
authors.forename: Lorraine
authors.initials: L
authors.lastname: Tilbury
authors.forename: Bennard
authors.initials: B
authors.lastname: van Ravenzwaay
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Wolf
mesh_terms: D016573:Agrochemicals / Q000633:toxicity*; D003628:Database Management Systems; D004781:Environmental Exposure; D006801:Humans; D018570:Risk Assessment; D017751:Safety Management; D018675:Toxicity Tests / Q000379:methods
chemical_list: D016573:Agrochemicals