title: The spectrum of orbital Rosai-Dorfman disease.
abstract: OBJECTIVE
  To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases.
  
  
  METHODS
  Retrospective, interventional case series of seven patients and literature review.
  
  
  RESULTS
  Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable.
  
  
  CONCLUSIONS
  Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.
authors.affiliation: Department of Ophthalmology, Saint Louis University, MO 63141, USA,
authors.forename: Yasaman
authors.initials: Y
authors.lastname: Mohadjer
authors.forename: John B
authors.initials: JB
authors.lastname: Holds
authors.forename: Jack
authors.initials: J
authors.lastname: Rootman
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Wilson
authors.forename: James W
authors.initials: JW
authors.lastname: Gigantelli
authors.forename: Philip L
authors.initials: PL
authors.lastname: Custer
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed