title: SPECT in periodic lateralized epileptiform discharges (PLEDs): a case report on PLEDs.
abstract: Periodic lateralized epileptiform discharges (PLEDs), which are known as unusual electroencephalogram (EEG) patterns, are described in a patient who had stroke and seizures. This patient underwent Tc-99m HMPAO (hexamethyl propylene amine oxime) brain single photon emission computed tomography (SPECT) imaging both during PLEDs on EEG and after the cessation of PLEDs. The initial SPECT study revealed increased CBF in the left frontal and parietal cortex extending through the left temporal region and in the left basal ganglium. After the PLEDs disappeared, the second SPECT study showed decreased perfusion on the left frontal and parietal region in the brain. Brain SPECT findings supported the contention that PLEDs may be an ictal phenomenon. Here we also present a review on PLEDs and contributions of brain SPECT as a functional imaging modality to investigate the underlying mechanism of this interesting EEG pattern.
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey. eergul@hacettepe.edu.tr
authors.forename: Eser Lay
authors.initials: EL
authors.lastname: Ergün
authors.forename: Bilge Volkan
authors.initials: BV
authors.lastname: Salanci
authors.forename: Belkis
authors.initials: B
authors.lastname: Erbaş
authors.forename: Serap
authors.initials: S
authors.lastname: Saygi
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000379:methods*; D004827:Epilepsy / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime