title: Genetic toggle switch without cooperative binding.
abstract: Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
authors.affiliation: Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Azi
authors.initials: A
authors.lastname: Lipshtat
authors.forename: Adiel
authors.initials: A
authors.lastname: Loinger
authors.forename: Nathalie Q
authors.initials: NQ
authors.lastname: Balaban
authors.forename: Ofer
authors.initials: O
authors.lastname: Biham
mesh_terms: D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008957:Models, Genetic; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors