title: Cushing's syndrome.
abstract: Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.
authors.affiliation: Division of Clinical Sciences, University of Sheffield, Northern General Hospital, Sheffield, UK. j.newellprice@sheffield.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Newell-Price
authors.forename: Xavier
authors.initials: X
authors.lastname: Bertagna
authors.forename: Ashley B
authors.initials: AB
authors.lastname: Grossman
authors.forename: Lynnette K
authors.initials: LK
authors.lastname: Nieman
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000502:physiology; D003480:Cushing Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008297:Male
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone