[Optimization of formulation of Fufang Danshen immediate release tablet by colligation score].
OBJECTIVE
To optimize the formulation of immediate release tablet.


METHODS
The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.


RESULTS
The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.


CONCLUSIONS
It is successful to prepare on immediate release tablet using the optimized formula above.
Hu
Rong-feng
RF
Institute of Pharmaceutics, China Pharmaceutical University, Nanjing. rongfenghu2003@hotmail.com
Zhu
Jia-bi
JB
Peng
Dai-yin
DY
Tang
Ji-hui
JH
Zhou
An
A
D002482:Cellulose; D003912:Dextrins; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013607:Tablets
D003912:Dextrins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D002482:Cellulose