Adipose-derived stem cells for the regeneration of damaged tissues.
As the promise of stem cell-based therapies begins to be realised, and efforts to bring advances to the clinic mount, the source of these cells is increasingly important. The morbidity associated with harvesting stem cells from solid organs and the invasive nature of bone marrow biopsies may limit their practicality for wider clinical applications. An emerging body of literature suggests that adipose tissue may provide an abundant, readily accessible source of cells with similar potential to that described of other adult stem cells. This review will address advances in the use of adipose stem cells in fields as divergent as soft tissue reconstruction and cerebral infarction recovery. Numerous challenges will also be discussed; however, rapidly accumulating advances suggest that adipose stem cells may be as effective as they are abundant.
Parker
Anna M
AM
Department of Plastic Surgery, University of Virginia, Charlottesville, VA 22908, USA. annamparker@gmail.com
Katz
Adam J
AJ
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D017690:Cell Transplantation / Q000379:methods*; D020219:Chondrogenesis; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D010012:Osteogenesis; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*