The temporal and spatial expression pattern of myosin Va, Vb and VI in the mouse ovary.
There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.
McGurk
Leeanne
L
MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, United Kingdom. leeanne.mcgurk@hgu.mrc.ac.uk
Tzolovsky
George
G
Spears
Norah
N
Bownes
Mary
M
D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006107:Granulosa Cells / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018995:Myosin Heavy Chains / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism*; D006080:Ovarian Follicle / Q000254:growth & development / Q000378:metabolism; D010053:Ovary / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
C505832:MYO5B protein, human; C513082:Myo5a protein, mouse; D012333:RNA, Messenger; C089785:myosin VI; D024701:Myosin Type V; D018995:Myosin Heavy Chains