Effects of Chinese herbal medicine based on hachimi-jio-gan on osteopenia in rats.
The effects of Chinese herbal medicines including Hachimi-jio-gan (HJG) and/or Hochu-ekki-to (HEW) on osteopenia in rats were investigated. The Chinese herbal medicines were administrated for 8 weeks (7 times/week) starting from 1 week after ovariectomy. HJG and Prescription-2 (Prsc-2, the prescription based on HJG) showed protective effect on bone loss of the vertebrae after ovariectomy. However, Prescription-1 (the prescription based on HJG and HET) had no effect. Then, we made osteopenia model in rats by prednisolone and low calcium diet. Prsc-2 and HJG were administrated for 20 weeks with prednisolone. These Chinese remedies showed protective effects for osteopenia, with better indices on bone loss of the limbs than HJG alone in the osteopenia rats. It can be concluded that Prsc-2 is more effective than HJG for bone loss induced by various factors, and the additives in Prsc-2 may enhance the therapeutic effect.
Kanehara
Masayuki
M
Institute of Traditional Chinese Medicine, Suzuka University of Medical Science, 1001-1, Kishioka, Suzuka, Mie Pref 510-0293, Japan.
Ogirima
Takeshi
T
Tano
Kaori
K
Maenaka
Toshihiro
T
Ishida
Torao
T
Zhang
Bingli
B
Li
Guilan
G
Wang
Xiuyun
X
Guo
Yi
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D010052:Ovariectomy; D008517:Phytotherapy; D011239:Prednisolone; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; C402943:bu-zhong-yi-qi-tang; C054591:hachimijiogan; D011239:Prednisolone