title: Toll-like receptors and graft rejection.
abstract: Innate immunity plays a role in fighting against invading microorganisms. Emerging evidence suggests that in addition to responding to pathogen-associated molecular patterns of microorganisms, Toll-like receptors (TLRs) can be activated by endogenous ligands expressed by mammalian cells. Clinical and laboratory studies have shown that TLRs may participate in organ graft rejection and transplant immune tolerance, which are briefly reviewed in the present manuscript.
authors.affiliation: Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Liu
authors.forename: You
authors.initials: Y
authors.lastname: Wu
authors.forename: Shouliang
authors.initials: S
authors.lastname: Gong
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D051193:Toll-Like Receptors / Q000502:physiology*
chemical_list: D051193:Toll-Like Receptors