title: Antioxidative actions of statins: potential mechanisms for antiathersclerotic effects.
abstract: Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.
authors.affiliation: Department of Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yasunari
authors.forename: Munehoro
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors