title: Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.
abstract: HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
authors.affiliation: Department of Medical Biochemistry and Microbiology, The Biomedical Center, Uppsala University, Sweden. Sindhulakshmi.kurup@imbim.uu.se
authors.forename: S
authors.initials: S
authors.lastname: Kurup
authors.forename: A
authors.initials: A
authors.lastname: Abramsson
authors.forename: J P
authors.initials: JP
authors.lastname: Li
authors.forename: U
authors.initials: U
authors.lastname: Lindahl
authors.forename: L
authors.initials: L
authors.lastname: Kjellen
authors.forename: C
authors.initials: C
authors.lastname: Betsholtz
authors.forename: H
authors.initials: H
authors.lastname: Gerhardt
authors.forename: D
authors.initials: D
authors.lastname: Spillmann
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006497:Heparan Sulfate / Q000502:physiology*; D006801:Humans; D020286:Pericytes / Q000502:physiology*; D020574:Proto-Oncogene Proteins c-sis / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism
chemical_list: D006497:Heparan Sulfate; D020574:Proto-Oncogene Proteins c-sis; D017479:Receptors, Platelet-Derived Growth Factor