title: Magnetic resonance imaging changes in Fabry disease.
abstract: Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non-specific white and grey matter lesions, vascular anomalies, in particular dolicho-ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age.
  
  
  CONCLUSIONS
  MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.
authors.affiliation: Department of Neurology, Royal Free Hospital, London, UK. Lionel.Ginsberg@royalfree.nhs.uk
authors.forename: Lionel
authors.initials: L
authors.lastname: Ginsberg
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Alan R
authors.initials: AR
authors.lastname: Valentine
authors.forename: Brian
authors.initials: B
authors.lastname: Kendall
authors.forename: Alessandro P
authors.initials: AP
authors.lastname: Burlina
mesh_terms: D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology; D000795:Fabry Disease / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging