title: [Nephrogenic diabetes insipidus induced by colchicine--a case report].
abstract: In some cases diabetes insipidus may be induced by taking medications. In this article we report the case of a 58-year-old man with manifest polyuria induced by colchicine administered because of a gout attack. Interestingly, similar symptoms were observed 6 years earlier after treatment with gentamycin. In the described state of the examined patient early detection of the disease, colchicine withdrawal and temporary amiloride (and indometacin) administration led to a full normalisation of the patient's clinical status. A similar reaction to two different drugs responsible for only a small percentage of iatrogenic diabetes insipidus suggests that some patients may exhibit a general "hypersensitivity" to the development of a drug-induced vasopressin resistance and that patients with the history of iatrogenic diabetes insipidus should not be treated or should be treated cautiously with other drugs known to induce vasopressin-resistant polyuria.
authors.affiliation: Katedra Farmakologii, Zakład Farmakologii Klinicznej Slaskiej Akademii Medycznej, Katowice. r.krysiak@pharmanet.com.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Bogusław
authors.initials: B
authors.lastname: Okopień
authors.forename: Maciej
authors.initials: M
authors.lastname: Haberka
authors.forename: Zbigniew Stanisław
authors.initials: ZS
authors.lastname: Herman
mesh_terms: D000584:Amiloride / Q000627:therapeutic use*; D003078:Colchicine / Q000009:adverse effects* / Q000627:therapeutic use; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000188:drug therapy*; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011141:Polyuria
chemical_list: D000584:Amiloride; D003078:Colchicine