The trypanolytic factor of human serum.
African trypanosomes (the prototype of which is Trypanosoma brucei brucei) are protozoan parasites that infect a wide range of mammals. Human blood, unlike the blood of other mammals, has efficient trypanolytic activity, and this needs to be counteracted by these parasites. Resistance to this activity has arisen in two subspecies of Trypanosoma brucei - Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense - allowing these parasites to infect humans, and this results in sleeping sickness in East Africa and West Africa, respectively. Study of the mechanism by which T. b. rhodesiense escapes lysis by human serum led to the identification of an ionic-pore-forming apolipoprotein - known as apolipoprotein L1 - that is associated with high-density-lipoprotein particles in human blood. In this Opinion article, we argue that apolipoprotein L1 is the factor that is responsible for the trypanolytic activity of human serum.
Pays
Etienne
E
Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium. epays@ulb.ac.be
Vanhollebeke
Benoit
B
Vanhamme
Luc
L
Paturiaux-Hanocq
Françoise
F
Nolan
Derek P
DP
Pérez-Morga
David
D
D000818:Animals; D000951:Antigens, Neoplasm / Q000502:physiology; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000502:physiology*; D001798:Blood Proteins / Q000502:physiology; D006242:Haptoglobins / Q000502:physiology; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D008075:Lipoproteins, HDL / Q000502:physiology*; D014347:Trypanosoma brucei gambiense / Q000276:immunology / Q000502:physiology*; D016833:Trypanosoma brucei rhodesiense / Q000276:immunology / Q000502:physiology*; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000469:parasitology
C108666:APOL1 protein, human; D000951:Antigens, Neoplasm; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D001798:Blood Proteins; C058632:HPR protein, human; D006242:Haptoglobins; D007106:Immune Sera; D008075:Lipoproteins, HDL