Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal.
We performed pulsed-field gel electrophoresis (XbaI) on 114 bloodstream isolates of Salmonella enterica serotype Paratyphi A and S. enterica serotype Typhi collected from febrile patients in Kathmandu, Nepal. Of the 56 S. Paratyphi A isolates, 51 (91%) were indistinguishable, which suggests the emergence of a single clone. In contrast, only 21 (36%) of the 58 S. Typhi isolates exhibited a common genotype, which is consistent with endemic disease from multiple sources.
Woods
Christopher W
CW
Duke University Medical Center, Durham, NC, USA. woods004@mc.duke.edu
Murdoch
David R
DR
Zimmerman
Mark D
MD
Glover
William A
WA
Basnyat
Buddha
B
Wolf
Leslie
L
Belbase
Ram Hari
RH
Reller
L Barth
LB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D010284:Paratyphoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D012482:Salmonella paratyphi A / Q000302:isolation & purification*; D014435:Typhoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D014504:Urban Health
D000890:Anti-Infective Agents