Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa.
[structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses, and supported by their unique biosynthetic pathway as proposed. Both 1 and 2 were tested against two tumor cell lines, and alkaloid 1 showed weak activity against the P-388 cell line.
Gan
Li-She
LS
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, PR China.
Fan
Cheng-Qi
CQ
Yang
Sheng-Ping
SP
Wu
Yan
Y
Lin
Li-Ping
LP
Ding
Jian
J
Yue
Jian-Min
JM
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D007212:Indolizines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids; D001381:Azepines; D007212:Indolizines; D010880:Piperidines; C518051:flueggenine A; C518052:flueggenine B; C050244:norsecurinine