Fusariosis occurring in an ulcerated cutaneous CD8+ T cell lymphoma tumor.
Fusarium species have recently emerged as the second most common pathogenic mold in immunocompromised patients, and they are moderately resistant to most antifungal agents. The skin lesions of disseminated fusariosis typically manifest as multiple red or violaceous macules or nodules, often ulcerated and covered by a black eschar. We report a case of cutaneous fusariosis in a patient with long-standing hypopigmented mycosis fungoides. The infection was successfully treated with a 3-month course of oral voriconazole. The present case is unusual in that the infection occurred within a pre-existing, ulcerated lesion of cutaneous CD8+ lymphoma, resulting clinically in confusion with pyoderma gangrenosum and necrosis of lymphoma. A high index of suspicion will prompt a timely biopsy as well as isolation of the fungus, and early institution of systemic antifungal therapy.
Hsu
Chao-Kai
CK
Department of Dermatology, National Cheng Kung University Medical Center, Tainan, Taiwan.
Hsu
Mark Ming-Long
MM
Lee
Julia Yu-Yun
JY
D000935:Antifungal Agents / Q000627:therapeutic use; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D017931:DNA Primers; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D009181:Mycoses / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D017931:DNA Primers; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole