title: Dementia in subjects aged 75 years or over within the PAQUID cohort: prevalence and burden by severity.
abstract: OBJECTIVE
  To analyze the prevalence of dementia by severity and to describe the sociodemographic characteristics of people with dementia in the community, as well as the consequences of this disease in terms of disability and institutionalization.
  
  
  METHODS
  This study was based on the PAQUID community-based cohort study of 1,461 subjects aged 75 years or over. Severity of dementia was assessed using the Mini-Mental State Examination (MMSE).
  
  
  RESULTS
  The prevalence of dementia was estimated to be 17.8%, with about 43% at a moderately severe or more severe stage of the disease (MMSE <or= 15). About 39% of the people with dementia lived in an institution. Among the institutionalized residents, 71.6% were diagnosed as demented. About 57% of the people with dementia were ADL disabled. In this over-75 population, people with dementia accounted for 74% of the ADL-disabled subjects. The consequences of dementia were particularly frequent among the subjects who were at least at a moderately severe stage of dementia, with 59.6% of them living in institution and 87.2% being ADL disabled.
  
  
  CONCLUSIONS
  These results confirm the high prevalence of dementia in subjects aged over 75 and illustrate the devastating consequences of this disease in terms of disability and institutionalization.
authors.affiliation: INSERM U. 593 - Université de Bordeaux 2, Bordeaux, France. Catherine.Helmer@isped.u-bordeaux2.fr
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.forename: Karine
authors.initials: K
authors.lastname: Pérès
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Guttiérez-Robledo
authors.forename: Hanta
authors.initials: H
authors.lastname: Ramaroson
authors.forename: Pascale
authors.initials: P
authors.lastname: Barberger-Gateau
authors.forename: Colette
authors.initials: C
authors.lastname: Fabrigoule
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Orgogozo
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D017281:Cost of Illness; D003704:Dementia / Q000453:epidemiology* / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007326:Institutionalization / Q000706:statistics & numerical data; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011594:Psychometrics; D012737:Sex Factors; D012959:Socioeconomic Factors