COX-2 and sPLA2 inhibitory activity of aqueous extract and polyphenols of Rhizophora mangle (red mangrove).
The aqueous extract of Rhizophora mangle bark and its polyphenolic fractions showed remarkable in vitro antiinflammatory activity in a preliminary study. The low molecular weight fraction exhibited cyclooxygenase-2 inhibitory activity while the total aqueous extract and the low molecular weight fraction showed secretory phospholipase A(2) inhibitory activity.
Marrero
Evangelina
E
National Center for Animal and Plant Health, CENSA, Apdo 10, San José de las Lajas, La Habana, Cuba. evadidem@censa.edu.cu
Sánchez
Janet
J
de Armas
Elizabeth
E
Escobar
Arturo
A
Melchor
Gleiby
G
Abad
M J
MJ
Bermejo
Paulina
P
Villar
Angel M
AM
Megías
J
J
Alcaraz
Maria J
MJ
D051546:Cyclooxygenase 2 / Q000187:drug effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000187:drug effects*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols; D043982:Rhizophoraceae
D052246:Cyclooxygenase 2 Inhibitors; D004791:Enzyme Inhibitors; D005419:Flavonoids; D008565:Membrane Proteins; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D010741:Phospholipases A