title: Upstream toward the "DRiP"-ing source of the MHC class I pathway.
abstract: MHC class I binding peptides are generated via cytosolic degradation of a previously undefined substrate. In this issue of Immunity, pre-degradation polypeptide intermediates bound to a cytosolic chaperone is isolated.
authors.affiliation: Department of Microbiology and Immunology, Pennsylvania State University, Milton S. Hershey College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Norbury
authors.forename: Eric F
authors.initials: EF
authors.lastname: Tewalt
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; D010455:Peptides