title: Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics.
abstract: According to WHO, suicide accounts for about 1,000,000 deaths worldwide every year. In view of these dramatic data, several studies have tried to identify possible biological mechanisms and markers of suicide. Genes encoding for proteins involved in the serotonergic transmission are major candidates in association studies of suicidal behavior. The gene that codes for tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, is one of these candidates. Two polymorphisms in intron 7 of this gene (A218C and A779C) have been described, but their role in suicidal behavior remains uncertain. TPH A218C polymorphism was analyzed in a sample of 248 psychiatric patients and 63 healthy controls. In addition, at least one close relative member was interviewed to assess family suicidal behavior history. Our research confirmed that a positive history of suicide attempts in a family member is associated with the chance of an individual to attempt suicide. Furthermore, we demonstrated that familial suicide attempts are more lethal and frequently more violent. We were not able to find significant differences of the TPH genotype frequencies between patients and controls. The TPH A218C genotypes were not associated with a history of suicide attempt and the lethality of the most lethal lifetime suicide attempt and suicide attempt method. The authors conclude that the A218C polymorphism of the TPH gene may not be a susceptibility factor for suicidal behavior in this group of psychiatric patients but confirm that a family suicidal behavior history increases the proband's suicide attempt risk.
authors.affiliation: Department of Pharmacology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
authors.forename: M M
authors.initials: MM
authors.lastname: Viana
authors.forename: L A
authors.initials: LA
authors.lastname: De Marco
authors.forename: W L
authors.initials: WL
authors.lastname: Boson
authors.forename: M A
authors.initials: MA
authors.lastname: Romano-Silva
authors.forename: H
authors.initials: H
authors.lastname: Corrêa
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics / Q000523:psychology; D001938:Brazil; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics; D012565:Schizophrenic Psychology; D013405:Suicide / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D014365:Tryptophan Hydroxylase