[Model experiment and numerical simulation of marginal pressure in the flow field downstream of the stenostic vessel in vitro].
For the defects of interpreting the relationship between the distribution and severity of vascular stenostic disease and the low shear stress, the study focus on and explore the rules of the pressure distribution and variation downstream of the stenostic vessel with the numerical simulation and the hydrodynamic model of turbulent flow separation area for in vitro experiment. The results reveal that there is a good compatibility between the model experiment and the numerical simulation; there exists a marked pressure decrease downstream of the stenosis. And the distribution area of low pressure is similar to the characteristic distribution of the stenostic vessel diseases. The study suggested that the numerical simulation can be applied in the study of micro-flow field; the presure distribution and variatioin downstream of the stenostic vessel maybe another factor to trigger the pathogenesis of vessel stenostic diseases.
Guo
Yingqiang
Y
Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. guo-yq@vip.sina.com
Shi
Yingkan
Y
Zhang
Jianmin
J
Xue
Weilin
W
Liu
Shanjun
S
D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003251:Constriction, Pathologic / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D014652:Vascular Diseases / Q000503:physiopathology*