Inhibition of intestinal motility and secretion by extracts of Epilobium spp. in mice.
Ethanol extracts of the fresh aerial parts of various Epilobium species were tested to elucidate the mechanism of their gastrointestinal activity in animals. The methods of charcoal meal, castor oil-induced diarrhoea, and enteropooling assay were used to evaluate their effect on mouse gut at various dose levels. The extracts were found to have a significant activity in all models. Moreover, the extracts resulted to possess very little toxicity. Thus, it can be concluded that Epilobium possesses anti-diarrhoeal, anti-motility, and anti-secretory activities and can prove beneficial in the treatment of gastrointestinal disorders.
Vitali
Federica
F
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale A. Moro 5, 00185 Rome, Italy. fvitali@pharma.unime.it
Fonte
Giuseppina
G
Saija
Antonella
A
Tita
Beatrice
B
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D031666:Epilobium; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D007419:Intestinal Secretions / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits
D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil