Total synthesis of (-)-mucocin.
[reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments.
Crimmins
Michael T
MT
Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, 27599, USA.
Zhang
Yan
Y
Diaz
Frank A
FA
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D031045:Rollinia / Q000737:chemistry; D013237:Stereoisomerism
D007783:Lactones; D011714:Pyrans; C413144:mucocin