title: [Effects of xuefu zhuyu decoction on functions of vascular endothelium in patients with unstable angina pectoris].
abstract: OBJECTIVE
  To evaluate the effects of Xuefu Zhuyu Decoction (XFZYD) on functions of vascular endothelium in patients with unstable angina pectoris (UAP).
  
  
  METHODS
  Fifty patients with UAP were randomly divided into two groups: XFZYD-treated group with 32 cases and control group with 18 cases. The patients in the control group were given regular therapy, while the patients in the XFZYD-treated group were given XFZYD additionally on the basis of regular therapy. All patients in both groups were treated for 8 weeks. Then the contents of serum endothelin (ET), nitric oxide (NO), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were examined by radioimmunoassay, enzymic method and enzyme-linked immunosorbent assay (ELISA) respectively.
  
  
  RESULTS
  The total response rate in the XFZYD-treated group was 93.75%, which was significantly higher than 66.67% in the control group (P<0.05). The contents of serum ET, sVCAM-1 and sICAM-1 in the XFZYD-treated group were much lower than those in the control group (P<0.01), while the content of serum NO was obviously higher than that in the control group (P<0.01).
  
  
  CONCLUSIONS
  XFZYD can improve the functions of vascular endothelium by lowering the levels of endothelium-derived contracting substances, enhancing the levels of endothelium-derived relaxing substances, and reducing the cell adhesions, and hence to raise the therapeutic effects on UAP.
authors.affiliation: Department of Traditional Chinese Medicine, 456th Hospital of People's Liberation Army, Jinan, Shandong Province 250031, China. WBXXiang@163.com
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Wang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Dong
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy* / Q000503:physiopathology; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D019010:Vascular Cell Adhesion Molecule-1; D009569:Nitric Oxide