title: A new case of Grange syndrome without cardiac findings.
abstract: Grange syndrome comprises arterial stenoses with hypertension, brachysyndactyly, bone fragility, learning disability, and cardiac defects. To date, we know of two reported families with five affected individuals. We report on one of the youngest cases, in a third family, a 3-year-old girl with brachysyndactyly, renal artery stenosis with hypertension, and bone fragility. She does not have apparent cardiac disease, suggesting cardiac anomalies may not be an obligatory finding in this syndrome.
authors.affiliation: Genetics Service, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA. rwallerstein@humed.com
authors.forename: Robert
authors.initials: R
authors.lastname: Wallerstein
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Augustyn
authors.forename: Donna
authors.initials: D
authors.lastname: Wallerstein
authors.forename: Leslie
authors.initials: L
authors.lastname: Elton
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tejeiro
authors.forename: Valerie
authors.initials: V
authors.lastname: Johnson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lieberman
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D001851:Bone Diseases, Metabolic / Q000235:genetics; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications; D007859:Learning Disabilities / Q000235:genetics; D011859:Radiography; D012077:Renal Artery / Q000002:abnormalities / Q000000981:diagnostic imaging; D013576:Syndactyly / Q000000981:diagnostic imaging*; D013577:Syndrome