title: Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats.
abstract: The changes in spatial memory performances and the binding of hippocampal peripheral-type benzodiazepine receptor (PBR) induced by D-galactose (D-gal) were investigated in rats. The animals were randomly divided into two groups: saline-treated group and D-gal-induced aging group. All rats received 56 days of injection followed by 5 days of behavioral tests. The D-gal-induced aging rats presented significant impairment in water maze performance, compared with that in the saline-treated rats. A significant decrease in [3H]PK11195 binding in the synaptosomes from hippocampus in the D-gal-induced aging rats was observed, compared to that in the saline-treated rats. Meanwhile, the Scatchard analysis revealed that there was a decrease in Bmax, with no significant change in KD. Further analysis demonstrated that water maze performance was closely related to the PK11195 binding in all rats. These results suggest that D-gal decreased the density of PBR in hippocampal synaptosomes, which may be attributable to the progressive pathogenesis of aging in rats.
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: C F
authors.initials: CF
authors.lastname: Chen
authors.forename: S Y
authors.initials: SY
authors.lastname: Lang
authors.forename: P P
authors.initials: PP
authors.lastname: Zuo
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.forename: X Q
authors.initials: XQ
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Xia
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D005260:Female; D005690:Galactose / Q000378:metabolism / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D023421:Models, Animal; D009498:Neurotoxins / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
chemical_list: D007546:Isoquinolines; D009498:Neurotoxins; D011963:Receptors, GABA-A; D005690:Galactose; C037850:PK 11195