title: Efficient and practical synthesis of (R)-2-methylpyrrolidine.
abstract: An efficient, practical, and high yielding synthesis of (R)-2-methylpyrrolidine is described. The sequence allows for the scalable preparation of the target compound in just four synthetic steps and proceeds in 83% overall yield and >99% optical purity from readily available starting materials.
authors.affiliation: Department of Process Research, Merck & Company, Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. dalian_zhao@merck.com
authors.forename: Dalian
authors.initials: D
authors.lastname: Zhao
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Kuethe
authors.forename: Michel
authors.initials: M
authors.lastname: Journet
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Peng
authors.forename: Guy R
authors.initials: GR
authors.lastname: Humphrey
mesh_terms: D008967:Molecular Biology; D011759:Pyrrolidines / Q000138:chemical synthesis*
chemical_list: C520125:2-methylpyrrolidine; D011759:Pyrrolidines