Epstein-Barr virus (EBV) and its associated human cancers--genetics, epigenetics, pathobiology and novel therapeutics.
Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.
Tao
Qian
Q
Sir YK Pao Cancer Center, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong. qtao@clo.cuhk.edu.hk
Young
Lawrence S
LS
Woodman
Ciaran B J
CB
Murray
Paul G
PG
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000628:therapy; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D015316:Genetic Therapy; D014644:Genetic Variation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000821:virology*; D014611:Vaccination