title: Effects of aspirin and mefenamic acid on soman poisoning-induced neuropathology in mice.
abstract: The efficacy of aspirin and mefenamic acid to counteract soman-induced brain damage was investigated in mice. Neuronal damage was evaluated in the hippocampus and amygdala by performing omega3 receptor density measurements and hemalun-phloxin staining. The effect of both drugs on the proliferation of neural progenitors after soman exposure was also assessed. Mefenamic acid aggravated the soman-induced hippocampal neuropathology. On the other hand, aspirin recorded a weak neuroprotective effect in the amygdala. However, this drug also diminished the proliferation of neural precursor cells. The possible neurochemical mechanisms underlying such differences in the efficacy of the two drugs are also reviewed.
authors.affiliation: Département de Toxicologie, CRSSA, La Tronche, France. jmcollombet@crssa.net
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Collombet
authors.forename: Dominique
authors.initials: D
authors.lastname: Baubichon
authors.forename: Catherine
authors.initials: C
authors.lastname: Masqueliez
authors.forename: Denis
authors.initials: D
authors.lastname: Bernabé
authors.forename: Elise
authors.initials: E
authors.lastname: Four
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Burckhart
authors.forename: Guy
authors.initials: G
authors.lastname: Lallement
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects; D002619:Chemical Warfare Agents / Q000506:poisoning*; D004359:Drug Therapy, Combination; D007279:Injections, Subcutaneous; D008297:Male; D008528:Mefenamic Acid / Q000627:therapeutic use*; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012999:Soman / Q000506:poisoning*; D013234:Stem Cells / Q000187:drug effects / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002619:Chemical Warfare Agents; D018696:Neuroprotective Agents; D008528:Mefenamic Acid; D012999:Soman; D001241:Aspirin