Amphibian muscle regeneration--dedifferentiation or satellite cells?
Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage regeneration was believed to arise by dedifferentiation of myofibres to form myoblasts. But recent work shows that muscle satellite cells are also involved in amphibian regeneration and the controversy about the reality of muscle dedifferentiation is heating up again.
Slack
Jonathan M W
JM
Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. j.m.w.slack@bath.ac.uk
D000663:Amphibians / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D009132:Muscles / Q000503:physiopathology*; D032446:Myoblasts / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology*; D014945:Wound Healing