title: Yeast Protein Interactome topology provides framework for coordinated-functionality.
abstract: The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and 'Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pairwise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
authors.affiliation: Biometry Research Group, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. andre@deas.harvard.edu
authors.forename: André X C N
authors.initials: AX
authors.lastname: Valente
authors.forename: Michael E
authors.initials: ME
authors.lastname: Cusick
mesh_terms: D008954:Models, Biological; D025941:Protein Interaction Mapping / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification / Q000378:metabolism* / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins