title: Twenty years of clinical islet transplantation at the Diabetes Research Institute--University of Miami.
abstract: Transplantation of allogeneic pancreatic islets for the treatment of patients with Type 1 diabetes mellitus (T1DM) is now a reality. The steady progress that has allowed for the recent successful clinical trials world-wide follows a steep learning curve and the perseverance of the international islet transplantation community. The Clinical Islet Transplant Program at the Diabetes Research Institute - University of Miami has contributed to the progress in the field with a 20-year track record. It has been a long journey and despite the intermediate success, more work is needed in order to achieve the ultimate goal of a safe and long-lasting treatment for patients with T1DM.
authors.affiliation: Clinical Islet Transplant Program and Cell Transplant Center, Diabetes Research Institute, University of Miami, Leonard Miller School of Medicine, Miami, Florida, USA.
authors.forename: Antonello
authors.initials: A
authors.lastname: Pileggi
authors.forename: Camillo
authors.initials: C
authors.lastname: Ricordi
authors.forename: Norma S
authors.initials: NS
authors.lastname: Kenyon
authors.forename: Tatiana
authors.initials: T
authors.lastname: Froud
authors.forename: David A
authors.initials: DA
authors.lastname: Baidal
authors.forename: Aisha
authors.initials: A
authors.lastname: Kahn
authors.forename: Gennaro
authors.initials: G
authors.lastname: Selvaggi
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Alejandro
mesh_terms: D000047:Academies and Institutes; D001854:Bone Marrow Cells / Q000166:cytology; D002469:Cell Separation / Q000379:methods; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000601:surgery; D005431:Florida; D006085:Graft Survival; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016381:Islets of Langerhans Transplantation / Q000266:history / Q000379:methods / Q000639:trends*; D018579:Patient Selection; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods