Pharmacokinetic interaction between methotrexate and piperacillin/tazobactam resulting in prolonged toxic concentrations of methotrexate.
Zarychanski
R
R
Wlodarczyk
K
K
Ariano
R
R
Bow
E
E
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D010878:Piperacillin / Q000493:pharmacokinetics; D000077725:Piperacillin, Tazobactam Drug Combination
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin; D008727:Methotrexate