title: Expression of Notch1 and Hes5 in the developing olfactory epithelium.
abstract: CONCLUSIONS
  Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE.
  
  
  METHODS
  The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined.
  
  
  RESULTS
  As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan. y-orita@cc.okayama-u.ac.jp
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Tsujigiwa
authors.forename: Junko
authors.initials: J
authors.lastname: Yoshinobu
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Maeda
authors.forename: Masashi
authors.initials: M
authors.lastname: Kakiuchi
authors.forename: Saeko
authors.initials: S
authors.lastname: Orita
authors.forename: Ayako
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takeda
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nagai
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D005865:Gestational Age; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009831:Olfactory Mucosa / Q000254:growth & development* / Q000378:metabolism; D011247:Pregnancy; D051881:Receptor, Notch1 / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051881:Receptor, Notch1; D012097:Repressor Proteins; C489685:Hes5 protein, mouse; C497762:Notch1 protein, mouse