Wiring specificity: axon-dendrite matching refines the olfactory map.
In Drosophila, about 50 classes of olfactory receptor neurons enter the brain where their axons form highly specific synapses with the dendrites of identified partner neurons. A recent study has shown that genetic manipulations that shift the position of one class of postsynaptic dendrites can cause an exact corresponding shift in the location of their partner axons.
Jefferis
Gregory S X E
GS
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. gsxej2@cam.ac.uk
D000818:Animals; D001369:Axons / Q000502:physiology; D015815:Cell Adhesion Molecules; D003712:Dendrites / Q000502:physiology; D004330:Drosophila / Q000254:growth & development*; D029721:Drosophila Proteins / Q000502:physiology; D009833:Olfactory Pathways / Q000254:growth & development; D018034:Olfactory Receptor Neurons / Q000254:growth & development*
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C491736:Dscam1 protein, Drosophila