Genetic toggle switch without cooperative binding.
Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
Lipshtat
Azi
A
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.
Loinger
Adiel
A
Balaban
Nathalie Q
NQ
Biham
Ofer
O
D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008957:Models, Genetic; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors