title: An efficient direct amination of cyclic amides and cyclic ureas.
abstract: [reaction: see text] An efficient one-step amination of cyclic amides and ureas has been developed. Treatment of cyclic amides and cyclic ureas with BOP in the presence of DBU in various solvents led to the formation of cyclic amidines and cyclic guanidines in good to excellent yields. Concise syntheses of biologically intriguing kinetin and potent kinase inhibitor olomoucin were thus achieved in just one and two steps, respectively.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, Cambridge, Massachusetts 02140, USA. zwan@wyeth.com
authors.forename: Zhao-Kui
authors.initials: ZK
authors.lastname: Wan
authors.forename: Sumrit
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: Eva
authors.initials: E
authors.lastname: Binnun
authors.forename: Tarek
authors.initials: T
authors.lastname: Mansour
mesh_terms: D000577:Amides / Q000737:chemistry*; D000578:Amidines / Q000138:chemical synthesis*; D000586:Amination; D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis*; D007701:Kinetin / Q000138:chemical synthesis*; D015394:Molecular Structure; D014508:Urea / Q000737:chemistry*
chemical_list: D000577:Amides; D000578:Amidines; D006146:Guanidines; C090046:olomoucine; D014508:Urea; D007701:Kinetin