title: A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases.
abstract: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We present herein the case of a patient with hepatocellular carcinoma with multiple lung metastases in whom malignancy spontaneously regressed after taking Pheliinus linteus Mycelium. A 79-year-old man consulted our hospital complaining of epigastric discomfort. Abdominal MRI and CT revealed a 3 cm diameter tumor in the liver, and chest CT showed numerous nodular lesions. The levels of alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist-II (PIVKA-II) were very high. We diagnosed HCC with multiple lung metastases, and no therapy was performed. Independently he took exact from Phellinus linteus Mycelium for one month, and 6 months later the tumors appeared to be in complete regression. The mechanism underlying this intriguing phenomenon remains unknown.
authors.affiliation: Department of Radiology, Kansai Medical University, Nishinomiya Kyouritsu, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kojima
authors.forename: Noboru
authors.initials: N
authors.lastname: Tanigawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Kariya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komemushi
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Shomura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sawada
authors.forename: Eitatsu
authors.initials: E
authors.lastname: Arai
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Yokota
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D003904:Mitosporic Fungi; D009365:Neoplasm Regression, Spontaneous; D008517:Phytotherapy; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor