Cellular functions of TIP60.
TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated intensively. Recent data suggest that TIP60 has more divergent functions than originally thought and roles for TIP60 in many processes, such as cellular signalling, DNA damage repair, cell cycle and checkpoint control and apoptosis are emerging. TIP60 is a tightly regulated transcriptional coregulator, acting in a large multiprotein complex for a range of transcription factors including androgen receptor, Myc, STAT3, NF-kappaB, E2F1 and p53. This usually involves recruitment of TIP60 acetyltransferase activities to chromatin. Additionally, in response to DNA double strand breaks, TIP60 is recruited to DNA lesions where it participates both in the initial as well as the final stages of repair. Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions.
Sapountzi
Vasileia
V
Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, University of Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, United Kingdom.
Logan
Ian R
IR
Robson
Craig N
CN
D000123:Acetyltransferases / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D004260:DNA Repair / Q000502:physiology; D050684:E2F Transcription Factors / Q000502:physiology; D051548:Histone Acetyltransferases / Q000502:physiology*; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D016328:NF-kappa B / Q000502:physiology; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016564:Amyloid beta-Protein Precursor; D050684:E2F Transcription Factors; D016328:NF-kappa B; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5