Switch patterns before and after patent expiry of omeprazole: a case study in The Netherlands.
BACKGROUND
An increase of therapeutic substitution after patent expiry might have a negative effect on cost-savings generated with newly introduced generic drugs. To evaluate influences of patent expiry on therapeutic substitution, switch behaviour before and after patent expiry was investigated.


OBJECTIVE
To describe proton pump inhibitor use and investigate substitution patterns from omeprazole before and after patent expiry.


METHODS
Data were obtained from the InterAction DataBase. Proportional proton-pump inhibitor use was identified per quarter during the study period 2000-2003. For the second part two cohorts--one before and one after patent expiry--were defined. The number of switchers was quarterly identified during 2-year follow-up period. For statistical analyses the chi-square test and hazard ratio were used.


RESULTS
In proportional use, a downward trend for omeprazole was found. After patent expiry, significantly more patients switched to other proton pump inhibitors (P < 0.001). The hazard ratio of 0.62 (95% CI: 0.57-0.69), indicates that for every six patients switching before patent expiry, 10 patients switch after patent expiry.


CONCLUSIONS
After patent expiry more patients switch to another proton pump inhibitor. In light of the total savings achieved with generic omeprazole, the importance of this negative impact on total cost-savings on proton pump inhibitors is unclear.
Klok
R M
RM
Department of Social Pharmacy, Pharmaco-epidemiology & Pharmacotherapy, Groningen University Institute for Drug Exploration (GUIDE), Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. r.m.klok@rug.nl
Boersma
C
C
Oosterhuis
I
I
Visser
S T
ST
de Jong-van den Berg
L T W
LT
Postma
M J
MJ
D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009853:Omeprazole / Q000008:administration & dosage / Q000191:economics*; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000191:economics*
D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D009853:Omeprazole