title: Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas.
abstract: The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Vandergrift
authors.forename: Sunil J
authors.initials: SJ
authors.lastname: Patel
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Nicholas
authors.forename: Abhay K
authors.initials: AK
authors.lastname: Varma
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D000922:Immunotoxins / Q000008:administration & dosage*; D007260:Infusion Pumps / Q000639:trends; D011868:Radioisotopes / Q000008:administration & dosage*
chemical_list: D000922:Immunotoxins; D011868:Radioisotopes