title: [Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl].
abstract: OBJECTIVE
  To study the antihyperlipidemia effective constituent of Polygala fallax Hemsl.
  
  
  METHODS
  Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy.
  
  
  RESULTS
  Four triterpenoid saponins were isolated and determined as 3-O-beta-D-glucopyranosyl-( 1--> 2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) -beta-D-fucopyranosyl ester (I), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(3-O-acetyl)-beta-D-fucopyranosyl ester (II), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(4-O-acetyl) -beta-D-fucopyranosyl ester (II) and 3-O-beta-D-glucopyranosyl-(1--2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4 ) -alpha-L-rhamnopyranosyl-(1-->2 ) - (3,4-diacetyl) -beta-D-fucopyranosyl ester (IV).
  
  
  CONCLUSIONS
  The effective constituents of Polygala fallax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
authors.forename: Kang-Ping
authors.initials: KP
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jian-Bin
authors.initials: JB
authors.lastname: Tan
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Fu-Shuang
authors.initials: FS
authors.lastname: Li
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Huang
authors.forename: Bao-Chuan
authors.initials: BC
authors.lastname: Liu
authors.forename: Gui-Shan
authors.initials: GS
authors.lastname: Tan
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D012503:Saponins