title: Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma.
abstract: Umbilical metastasis (Sister Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of Sister Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, Sister Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of Sister Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.
authors.affiliation: Department of Surgery A, Soroka University Medical Center and Faculty of the Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. borkirsh@bgu.ac.il
authors.forename: Boris
authors.initials: B
authors.lastname: Kirshtein
authors.forename: Mihai
authors.initials: M
authors.lastname: Meirovitz
authors.forename: Elimelech
authors.initials: E
authors.lastname: Okon
authors.forename: Benjamin
authors.initials: B
authors.lastname: Piura
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D014472:Umbilicus
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin