Biopsy-proven acute tubular necrosis in a child attributed to vancomycin intoxication.
Acute renal failure in children treated with vancomycin typically presents with interstitial nephritis. There is debate as to the extent of direct tubular toxicity attributable to vancomycin, especially in the absence of aminoglycoside treatment. We report a case of acute tubular necrosis (ATN) associated with vancomycin toxicity in an 8-year-old boy where there is no likely alternate explanation for toxic or ischemic injury. Treatment with hemodialysis resulted in the elimination of vancomycin from the circulation and subsequent improvement in renal function.
Wicklow
Brandy Alexandra
BA
Department of Pediatrics and Child Health, Winnipeg Children's Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
Ogborn
Malcolm Robert
MR
Gibson
Ian William
IW
Blydt-Hansen
Tom David
TD
D000900:Anti-Bacterial Agents / Q000506:poisoning*; D001706:Biopsy; D002648:Child; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D014640:Vancomycin / Q000506:poisoning*
D000900:Anti-Bacterial Agents; D014640:Vancomycin