title: Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats.
abstract: The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical Research Institute, Inje University, Busan, Republic of Korea.
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun-Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D019579:Neocortex / Q000187:drug effects*; D000069348:Quetiapine Fumarate; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013312:Stress, Physiological / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D003987:Dibenzothiazepines; D012333:RNA, Messenger; D000069348:Quetiapine Fumarate