Women with HNPCC: a target population for the chemoprevention of gynecologic cancers.
Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.
Broaddus
Russell R
RR
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. rbroaddus@mdanderson.org
Lu
Karen H
KH
D018890:Chemoprevention; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000175:diagnosis; D016889:Endometrial Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008403:Mass Screening; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*