title: Diffusion-perfusion in intra-axial brain tumors with high relaxivity contrast agents.
abstract: A high relaxivity contrast agent is indicated for use in MRI of the central nervous system to visualize lesions with an abnormal blood-brain barrier (BBB) or abnormal vascularity of the brain. We evaluated MultiHance (gadobenate dimeglumine, Gd-BOPTA) on T2*-weighted perfusion imaging in 33 histologically proven intra-axial brain tumors. The higher T1 relaxivity, and therefore better contrast-enhanced T1 imaging led to significantly better tumor delineation. The higher T2 relaxivity allowed high quality T2* perfusion MRI and post processed rCBV maps, with a dose of 0.1 mmol/kg MultiHance.
authors.affiliation: MRI Center, Centre Hospitalier Lyon Sud, 69495, Pierre Bénite, France. francois.cotton@chu-lyon.fr
authors.forename: François
authors.initials: F
authors.lastname: Cotton
mesh_terms: D000293:Adolescent; D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009367:Neoplasm Staging; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine