Efficient and practical synthesis of (R)-2-methylpyrrolidine.
An efficient, practical, and high yielding synthesis of (R)-2-methylpyrrolidine is described. The sequence allows for the scalable preparation of the target compound in just four synthetic steps and proceeds in 83% overall yield and >99% optical purity from readily available starting materials.
Zhao
Dalian
D
Department of Process Research, Merck & Company, Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. dalian_zhao@merck.com
Kuethe
Jeffrey T
JT
Journet
Michel
M
Peng
Zhihui
Z
Humphrey
Guy R
GR
D008967:Molecular Biology; D011759:Pyrrolidines / Q000138:chemical synthesis*
C520125:2-methylpyrrolidine; D011759:Pyrrolidines