title: Well-differentiated chondrosarcoma of the humerus with prominent granular cell component: a hitherto unreported occurrence.
abstract: We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types, this is, to the best of our knowledge, the first documentation of this phenomenon in a skeletal chondrosarcoma.
authors.affiliation: Department of Pathology, University of Bologna, Bologna, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Cremonini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Kuhn
authors.forename: Pietro
authors.initials: P
authors.lastname: De Biase
authors.forename: Alessandro
authors.initials: A
authors.lastname: Franchi
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002813:Chondrosarcoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016586:Granular Cell Tumor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006811:Humerus / Q000473:pathology* / Q000601:surgery; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D009418:S100 Proteins