The frequency of HLA class I alleles in Japanese patients with bone marrow failure.
The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6%, p<0.002 and 7.7%, p<0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.
Shichishima
Tsutomu
T
Noji
Hideyoshi
H
Ikeda
Kazuhiko
K
Akutsu
Kazuko
K
Maruyama
Yukio
Y
D000741:Anemia, Aplastic / Q000235:genetics / Q000276:immunology / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005787:Gene Frequency; D006457:Hemoglobinuria, Paroxysmal / Q000235:genetics / Q000276:immunology / Q000628:therapy; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007564:Japan; D017211:Treatment Failure
D015395:Histocompatibility Antigens Class I