title: Autologous dendritic cells pulsed with eluted peptide as immunotherapy for advanced B-cell malignancies.
abstract: We have studied the feasibility, safety and efficacy of vaccination with autologous dendritic cells pulsed with eluted peptide in patients with advanced low-grade B-cell malignancies. This study demonstrates that autologous dendritic cell vaccines can be successfully produced from patients with advanced disease and be delivered without significant toxicity. Furthermore, we have demonstrated immunological and clinical responses in two of ten patients treated. These results provide further evidence for the use of immunotherapy in the management of B-cell malignancies, but also suggest that sustained responses may only be possible in patients with low bulk disease early in the disease course.
authors.affiliation: Malaghan Institute of Medical Research, Wellington, New Zealand. david.ritchie@petermac.org
authors.forename: David
authors.initials: D
authors.lastname: Ritchie
authors.forename: Ian
authors.initials: I
authors.lastname: Hermans
authors.forename: Jianping
authors.initials: J
authors.lastname: Yang
authors.forename: Julie
authors.initials: J
authors.lastname: Walton
authors.forename: Kate
authors.initials: K
authors.lastname: Matthews
authors.forename: John
authors.initials: J
authors.lastname: Carter
authors.forename: Michael
authors.initials: M
authors.lastname: Findlay
authors.forename: Peter
authors.initials: P
authors.lastname: Dady
authors.forename: Pisana
authors.initials: P
authors.lastname: Rawson
authors.forename: Franca
authors.initials: F
authors.lastname: Ronchese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000378:metabolism*; D019496:Cancer Vaccines / Q000737:chemistry*; D003713:Dendritic Cells / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000737:chemistry; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019496:Cancer Vaccines; D010455:Peptides