title: Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk.
abstract: There is strong evidence to suggest that the peroxisome proliferator-activated receptor (PPAR)-gamma, a member of the nuclear receptor family of transcriptional regulators, mediates tumor suppressive activities in a variety of human cancers. Recently, PPARgamma agonists were found to inhibit growth of melanoma cell lines. Here, we tested the possibility that variations in the gene encoding PPARgamma (PPARG) influence melanoma risk. Two variations of PPARG (P12A[rs1801282] and C161T [rs3856806]) were investigated in two independent case-control studies with a total of 832 melanoma patients and 790 control individuals. In the first study, homozygous carriers of the rare *T allele of the C161T polymorphism in exon 6 of PPARG were significantly more common among patients with melanoma than among healthy subjects (6.0 vs. 2.0%; P=0.0096) and this association was independent of clinical risk factors such as skin type and nevus count (odds ratio 5.18; 95% confidence interval 1.68-15.96; P=0.0041). This finding, however, could not be replicated in the second case-control study. We therefore conclude that the investigated PPARG polymorphisms are not likely to constitute a significant risk factor for the development of melanoma among German Caucasians.
authors.affiliation: Department of Dermatology, Georg-August-University, Von-Siebold-Strasse 3, D-37075 Göttingen, Germany.
authors.forename: Rotraut
authors.initials: R
authors.lastname: Mössner
authors.forename: Peter
authors.initials: P
authors.lastname: Meyer
authors.forename: Florian
authors.initials: F
authors.lastname: Jankowski
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Ullrich
authors.initials: U
authors.lastname: Krüger
authors.forename: Stefan
authors.initials: S
authors.lastname: Kammerer
authors.forename: Götz
authors.initials: G
authors.lastname: Westphal
authors.forename: Melanie B
authors.initials: MB
authors.lastname: Boettger
authors.forename: Carola
authors.initials: C
authors.lastname: Berking
authors.forename: Christina
authors.initials: C
authors.lastname: Schmitt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brockmöller
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Henrike
authors.initials: H
authors.lastname: Stapelmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Kaiser
authors.forename: Matthias
authors.initials: M
authors.lastname: Volkenandt
authors.forename: Kristian
authors.initials: K
authors.lastname: Reich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D047495:PPAR gamma