Mitochondrial Ca2+ transport, permeability transition and oxidative stress in cell death: implications in cardiotoxicity, neurodegeneration and dyslipidemias.
Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.
Vercesi
Anibal E
AE
Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brazil. anibal@unicamp.br
Kowaltowski
Alicia J
AJ
Oliveira
Helena C F
HC
Castilho
Roger F
RF
D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D016923:Cell Death; D050171:Dyslipidemias / Q000503:physiopathology; D006321:Heart / Q000187:drug effects; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D018384:Oxidative Stress; D010539:Permeability; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000503:physiopathology
D017382:Reactive Oxygen Species; D002118:Calcium