title: HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection.
abstract: DNA typing of human lymphocyte antigen (HLA)-dicloro-1-[beta]-D-ribofuranosyl-benzimidazole 1 (DRB1) alleles in 35 individuals serologically positive for T. cruzi and in 41 healthy controls was performed. DRB1*0409 allele was significantly more prevalent in seropositive individuals, with a trend being also observed for the DRB1*0701 and DRB1*1503 alleles. Although statistically insignificant, the latter was found more frequent in cases with cardiomyopathy.
authors.affiliation: Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario Suipacha 531, 2000 Rosario, Argentina. sigarcia@fbioyf.unr.edu.ar
authors.forename: Silvia
authors.initials: S
authors.lastname: García Borrás
authors.forename: Cristina
authors.initials: C
authors.lastname: Diez
authors.forename: Carlos
authors.initials: C
authors.lastname: Cotorruelo
authors.forename: Oscar
authors.initials: O
authors.lastname: Pellizon
authors.forename: Claudia
authors.initials: C
authors.lastname: Biondi
authors.forename: Juan
authors.initials: J
authors.lastname: Beloscar
authors.forename: Oscar
authors.initials: O
authors.lastname: Bottasso
authors.forename: Amelia
authors.initials: A
authors.lastname: Racca
mesh_terms: D000818:Animals; D001118:Argentina; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014349:Trypanosoma cruzi / Q000235:genetics
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains