Parkinson's disease and dementia.
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting about 1% of the population over the age of 60. In addition to motor abnormalities, there are several non-motor signs and symptoms that may create a considerable burden for patients and care-givers. Dementia is common and affects approximately 40% of PD patients during the course of the disease, the risk for the development of dementia being 6 times higher than in non-PD age-matched controls. In most cases, PD patients with dementia (PDD) display a dysexecutive syndrome and visuospatial deficits, while memory is relatively unaffected. The overlap between PDD and dementia with Lewy bodies suggests that they likely share similar underlying neuropathological processes.
Padovani
A
A
Department Medical and Surgical Sciences, Institute of Neurology, University of Brescia, P.zza Spedali Civili 1, I-25125 Brescia, Italy. padovani@med.unibs.it
Costanzi
C
C
Gilberti
N
N
Borroni
B
B
D003704:Dementia / Q000145:classification / Q000150:complications* / Q000473:pathology; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000473:pathology; D012306:Risk