title: Carbon monoxide inhibits superoxide dismutase and stimulates reactive oxygen species production by Desulfovibrio desulfuricans 1388.
abstract: The hypothesis that oxidative stress characterized by enhanced superoxide generation underlies the toxicity of some factors to living organisms has been investigated. It is shown that CO (5-6% in gas phase) changed some growth parameters (mu, t(d)) of the sulfate-reducing bacterium Desulfovibrio desulfuricans 1388. Enhanced O(2)(-) generation registered by EPR spectroscopy and adrenochrome method was observed when cells were incubated under CO. The SOD activity in cells from the exponential growth phase growing under CO was decreased 1.5-fold compared with the control cells growing under Ar. SOD activities in cells from the stationary growth phase growing with or without CO were comparable. The results support the concept that CO toxicity for sulfate-reducing bacteria is an oxidative stress that arises in cells oxidizing CO to CO(2).
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Kazan Science Center, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia. davydova@mail.knc.ru
authors.forename: M N
authors.initials: MN
authors.lastname: Davydova
authors.forename: N B
authors.initials: NB
authors.lastname: Tarasova