The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes.
A description of the structurally unusual "phomactin" family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.
Goldring
William P D
WP
School of Chemistry, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Pattenden
Gerald
G
D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D043823:Taxoids / Q000737:chemistry
D001952:Bridged-Ring Compounds; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D010972:Platelet Activating Factor; D043823:Taxoids; C413206:phomactin A; C080625:taxane