title: Ecological and evolutionary principles in immunology.
abstract: Experimental immunology has given rise to detailed insights into how immune cells react to infectious agents and fight pathogens. At the same time, however, the interplay between infectious agents and immune responses can be viewed as an ecological system in vivo. This is characterized by complex interactions between species of immune cells and populations of pathogens. This review discusses how an understanding of the immune system can be aided by the application of ecological and evolutionary principles: competition, predation, and the evolution of viruses in vivo. These concepts can shed light onto important immunological concepts such as the correlates of efficient virus control, immunodominance, the relationship between viral evolution and the development of pathology, as well as the ability of the immune system to control immunosuppressive infections.
authors.affiliation: Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA. dwodarz@uci.edu
authors.forename: Dominik
authors.initials: D
authors.lastname: Wodarz
mesh_terms: D000486:Allergy and Immunology; D005075:Biological Evolution; D004463:Ecology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007239:Infections / Q000276:immunology; D014780:Viruses / Q000276:immunology* / Q000472:pathogenicity