Lentiviral Vif: viral hijacker of the ubiquitin-proteasome system.
Since the beginning of time, microorganisms have been devising ways to bypass detection and destruction by our immune system. Therefore, it is no surprise that along with the identification of the cellular antiviral protein APOBEC3G (A3G) has come the recognition of the viral solution to this assault. Here, we review the research that led up to the identification of A3G and the mechanism that the human immunodeficiency virus protein Vif developed to evade A3G's antiviral activities.
Ehrlich
Elana S
ES
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Yu
Xiao-Fang
XF
D000071480:APOBEC-3G Deaminase; D000818:Animals; D003564:Cytidine Deaminase; D016346:Gene Products, vif / Q000276:immunology / Q000378:metabolism*; D015658:HIV Infections / Q000201:enzymology* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007109:Immunity; D009700:Nucleoside Deaminases / Q000276:immunology / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000276:immunology / Q000378:metabolism*; D012097:Repressor Proteins / Q000276:immunology / Q000378:metabolism*; D025801:Ubiquitin; D054320:vif Gene Products, Human Immunodeficiency Virus
D016346:Gene Products, vif; D012097:Repressor Proteins; D025801:Ubiquitin; D054320:vif Gene Products, Human Immunodeficiency Virus; D046988:Proteasome Endopeptidase Complex; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase