title: Hyalinizing clear cell carcinoma arising from the base of the tongue.
abstract: Hyalinizing clear cell carcinoma is a low-grade indolent and rare salivary gland tumor originally described by Milchgrub et al. in 1994. We herein report a case of this tumor of the base of the tongue. A 66-year-old Japanese woman presented with a large painless mass in the throat. Computed tomography and magnetic resonance imaging revealed a 40x30-mm well-defined ovoid tumor arising from the base of the tongue. She underwent tracheostomy followed by a resection of the tumor via the transmandibular approach combined with a right-sided supra-omohyoid neck dissection. Because the tumor invasion of the surrounding tissue was limited, the surgical defect at the base of the tongue was relatively small, and no reconstructive procedure needed to be performed. The tumor was histopathologically diagnosed as hyalinizing clear cell carcinoma of the minor salivary gland. Her postoperative clinical course was uneventful. No aspiration or difficulty upon deglutition was recognized when she started transoral ingestion on the eighth postoperative day. The patient is currently free from disease 21 months after surgery. The pathology, clinical characteristics, and treatment of hyalinizing clear cell carcinoma are bibliographically reviewed.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. suzuhyde@med.uoeh-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Akiko
authors.initials: A
authors.lastname: Katoh
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Udaka
authors.forename: Teruo
authors.initials: T
authors.lastname: Shiomori
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Fujimura
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Fujimura
authors.forename: Takuro
authors.initials: T
authors.lastname: Kitamura
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006818:Hyalin; D007828:Laryngoscopy; D008279:Magnetic Resonance Imaging; D037981:Neck Dissection; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012470:Salivary Glands, Minor / Q000473:pathology / Q000601:surgery; D017154:Stromal Cells / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014059:Tongue / Q000473:pathology / Q000601:surgery; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery