Immunosuppression and GB virus C-RNA detection among HIV-infected patients in Cambodia.
In this survey, 213 patients in an antiretroviral treatment programme in Phnom Penh, Cambodia, were tested for GB virus C (GBV-C) RNA before treatment initiation. Most had advanced HIV infection, only 34 having CD4 cell counts > 200 cells/microl. GBV-C-RNA was detected in 35 patients. The proportion with positive GBV-C-RNA decreased dramatically with CD4 cell counts < 100 cells/microl. In multivariate analysis, low CD4 cell counts, tuberculosis, anaemia, and traditional medicine were independently and negatively associated with GBV-C-RNA detection.
Sall
Amadou A
AA
Institut Pasteur de Dakar, Dakar, Senegal.
Ségéral
Olivier
O
Reynes
Jean-Marc
JM
Lay
Sreyrath
S
Ouk
Vara
V
Hak
Chan Roeun
CR
Keo
Cheng Lay
CL
Lefait
Robin R
RR
Delfraissy
Jean-François
JF
Fontanet
Arnaud
A
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D018178:Flaviviridae Infections / Q000276:immunology*; D029407:GB virus C / Q000302:isolation & purification*; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors
D012367:RNA, Viral