Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.
HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
Kurup
S
S
Department of Medical Biochemistry and Microbiology, The Biomedical Center, Uppsala University, Sweden. Sindhulakshmi.kurup@imbim.uu.se
Abramsson
A
A
Li
J P
JP
Lindahl
U
U
Kjellen
L
L
Betsholtz
C
C
Gerhardt
H
H
Spillmann
D
D
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006497:Heparan Sulfate / Q000502:physiology*; D006801:Humans; D020286:Pericytes / Q000502:physiology*; D020574:Proto-Oncogene Proteins c-sis / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism
D006497:Heparan Sulfate; D020574:Proto-Oncogene Proteins c-sis; D017479:Receptors, Platelet-Derived Growth Factor