Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome.
OBJECTIVE
The aim of the study was to evaluate if the diagnosis and treatment of uterine cavity abnormalities by hysteroscopy in patients undergoing IVF programme is of any value in improving clinical pregnancy outcome.


METHODS
520 patients participated in this prospective randomized study and were classified into two groups. Group I (n = 265) without office hysteroscopy. Group II (n = 255) had office hysteroscopy and was sub classified into Group II a and Group II b. Group II a (n = 160) had normal hysteroscopic findings whereas Group II b (n = 95) had abnormal office hysteroscopy findings, which were corrected at the same time.


RESULTS
There was no difference in the mean number of oocytes retrieved, fertilization rate, and number of embryos transferred among the patients in different groups. Statistically significant difference was observed in terms of clinical pregnancy rates between Group I and Group II a (26.2 and 44.44%, P < 0.05), and Group I and Group II b (26.2 and 39.55%, P < 0.05), respectively.


CONCLUSIONS
Patients with recurrent IVF embryo transfer failures after normal hysterosalpingography findings should also be reevaluated using hysteroscopy prior to further commencing IVF-embryo transfer cycles in order to enhance the clinical pregnancy rates.
Rama Raju
G A
GA
Embryology Division, Krishna IVF Clinic, Zillaparishad Junction, Visakhapatnam 530002, Andhra Pradesh, India. krishnaivf@yahoo.com
Shashi Kumari
G
G
Krishna
K M
KM
Prakash
G J
GJ
Madan
K
K
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014591:Uterine Diseases / Q000175:diagnosis* / Q000601:surgery; D014599:Uterus / Q000033:anatomy & histology / Q000473:pathology* / Q000601:surgery