title: The exosome and the proteasome: nano-compartments for degradation.
abstract: Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.
authors.affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
authors.forename: Esben
authors.initials: E
authors.lastname: Lorentzen
authors.forename: Elena
authors.initials: E
authors.lastname: Conti
mesh_terms: D001665:Binding Sites; D005095:Exoribonucleases / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D046911:Macromolecular Substances; D021122:Protein Subunits; D012313:RNA; D005095:Exoribonucleases; D046988:Proteasome Endopeptidase Complex