title: Development in infants with autism spectrum disorders: a prospective study.
abstract: BACKGROUND
  Autism is rarely diagnosed before three years of age despite evidence suggesting prenatal abnormalities in neurobiological processes. Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention.
  
  
  METHODS
  This prospective study of autism spectrum disorders (ASD) examined development using the Mullen Scales of Early Learning (MSEL) in 87 infants tested at target ages 6, 14, and 24 months. Participants came from infants at high risk (siblings of children with autism) and low risk (no family history of autism) groups. Based on language test scores, Autism Diagnostic Observation Schedule, and clinical judgment at 24 months of age, participants were categorized as: unaffected, ASD, or language delayed (LD). Longitudinal linear regression and ANOVA models were applied to MSEL raw scores, and estimates were compared between the three diagnostic groups.
  
  
  RESULTS
  No statistically significant group differences were detected at 6 months. By 14 months of age, the ASD group performed significantly worse than the unaffected group on all scales except Visual Reception. By 24 months of age, the ASD group performed significantly worse than the unaffected group in all domains, and worse than the language delayed group in Gross Motor, Fine Motor, and Receptive Language. The developmental trajectory of the ASD group was slower than the other groups', and showed a significant decrease in development between the first and second birthdays.
  
  
  CONCLUSIONS
  Variations from typical and language delayed development are detectable in many children with ASD using a measure of general development by 24 months of age. Unusual slowing in performance occurred between 14 and 24 months of age in ASD.
authors.affiliation: The Kennedy Krieger Institute, Center for Autism and Related Disorders, The Johns Hopkins School of Medicine, MD 21211, USA. landa@kennedykrieger.org
authors.forename: Rebecca
authors.initials: R
authors.lastname: Landa
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Garrett-Mayer
mesh_terms: D000465:Algorithms; D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology*; D002675:Child, Preschool; D003147:Communication Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D019957:Motor Skills Disorders / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies; D012720:Severity of Illness Index