title: [Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion].
abstract: An association between thrombophilic genes and obstetric conditions with early pregnancy termination has been previously proposed. In the present study we attempted to evaluate the possible association between thrombophilic genetic polymorphisms and habitual abortion (HA). Samples from two groups of volunteers were analyzed. The experimental group (n>100) was conformed by women attending the Centro Medico de Occidente, IMSS and their male couples, with a reproductive history ofat least three miscarriages. The reference group (n > 200) was composed by male and female healthy adults living in the state of Jalisco, Mexico. DNA was extracted from peripheral blood, and polymorphisms FII G20210A , FVG1691A, MTHFR C677T, ECA IID y TNF G-308A were typed by PCR-RFLP or -SSP. Genotype proportions in the reference group were in agreement with the HardyWeinberg expectations. Allele, genotype, and phenotype proportion inter-group comparisons did not show statistically significant differences. The present results could not demonstrate that thrombophilic polymorphisms constitute risk factors for HA in Jalisco.
authors.affiliation: Centro de Investigación Biomédica de Occidente IMSS, CUCS, Universidad de Guadalajara, Secretaría de Salud, Guadalajara, Jalisco, México.
authors.forename: Antonio
authors.initials: A
authors.lastname: Quintero-Ramos
authors.forename: Laura Leticia
authors.initials: LL
authors.lastname: Valdez-Vélázquez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Hernández
authors.forename: Luz Margarita
authors.initials: LM
authors.lastname: Baltazar
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Padilla-Gutiérrez
authors.forename: Yeminia
authors.initials: Y
authors.lastname: Valle
authors.forename: Katya
authors.initials: K
authors.lastname: Rodarte
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz
authors.forename: Martha
authors.initials: M
authors.lastname: Ortiz-Aranda
authors.forename: Norma
authors.initials: N
authors.lastname: Olivares
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivas
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors; D019851:Thrombophilia / Q000235:genetics*