Congenital anomalies associated with autism spectrum disorders.
This study examined whether major congenital structural anomalies identified in infancy occurred more frequently in children later diagnosed with autism spectrum disorders (ASD; n=417; 341 males, 76 females) than in comparison children (n=2,067; 1,681 males, 386 females). Participants were sampled from infants born at Kaiser Permanente Northern California facilities between 1995 and 1999 who remained health plan members for at least 2 years (n=88,163). Comparison children were frequency-matched to children with ASD according to sex, birth year, and birth hospital. Congenital anomalies were diagnosed in 10.8% of children with ASD and 6.2% of comparison children (crude odds ratio [ORc] 1.8, 95% confidence interval [CI] 1.3-2.6). This association remained significant after adjustment for key maternal and infant covariates (adjusted OR [ORa] 1.7, 95% CI 1.1-2.4). Almost all organ-system anomaly categories were more prevalent in children with ASD, however only gastrointestinal anomalies were significantly associated with ASD in adjusted analyses (1.9 vs 0.4%, ORa 5.1, 95% CI 1.8-14.1).
Wier
Megan L
ML
California Department of Health Services, Genetic Disease Branch, Sequoia Foundation, Richmond, USA.
Yoshida
Cathleen K
CK
Odouli
Roxana
R
Grether
Judith K
JK
Croen
Lisa A
LA
D000015:Abnormalities, Multiple / Q000453:epidemiology* / Q000209:etiology; D001321:Autistic Disorder / Q000453:epidemiology* / Q000209:etiology; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D002391:Catchment Area, Health; D004777:Environment; D005260:Female; D041981:Gastrointestinal Tract / Q000002:abnormalities; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D015995:Prevalence