Molecular aspects of ischemic heart disease: ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy.
Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness of gene therapy for stimulating angiogenesis, protecting the heart against reperfusion injury, and treating heart failure. Also discussed are future research directions, including the potential use of RNA interference and combined stem cell therapy and gene therapy for the treatment of cardiovascular disease.
Nordlie
Margaret A
MA
Division of Mathematics and Natural Sciences, University of Mary, Bismarck, ND, USA.
Wold
Loren E
LE
Simkhovich
Boris Z
BZ
Sesti
Casilde
C
Kloner
Robert A
RA
D000818:Animals; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000627:therapeutic use; D020869:Gene Expression Profiling; D015316:Genetic Therapy; D006333:Heart Failure / Q000235:genetics / Q000628:therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D009203:Myocardial Infarction / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D017202:Myocardial Ischemia / Q000235:genetics* / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000235:genetics* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000235:genetics; D034622:RNA Interference; D033581:Stem Cell Transplantation; D042442:Vascular Endothelial Growth Factors / Q000235:genetics / Q000627:therapeutic use; D020257:Ventricular Remodeling / Q000235:genetics
D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors