Pharmacological and clinical studies on purine nucleoside analogs--new anticancer agents.
More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.
Lech-Maranda
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E
Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-513 Lodz, Pabianicka 62, Poland.
Korycka
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A
Robak
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T
D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D011684:Purine Nucleosides / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D011684:Purine Nucleosides