Neuropathology of the dementias other than Alzheimer's.
Dementia is due to lesions destroying a large amount of circuits anatomically connected with, or functionally related to, the associative areas of the cortex and the limbic structures. Dementia is not only the clinical hallmark of neurodegenerative diseases, most often proteinopathies, primarily involving the cerebral cortex, but also a symptom frequently associated to movement disorders, or secondary to systemic or neurological, non-degenerative diseases. In the elderly, it is often the consequence of the cumulative effect of different diseases.
Bugiani
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Istituto Nazionale Neurologico Carlo Besta, Milan, Italy. bugiani1@virgilio.it
D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans