title: Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition.
abstract: Cocaine treatment trials suffer from a high rate of attrition. We examined pretreatment neurophysiological factors to identify participants at greatest risk. Twenty-five participants were divided into concordant and discordant groups following electroencephalogram (EEG) measures recorded prior to a double-blind, placebo-controlled treatment trial. Three possible outcomes were examined: successful completion, dropout, and removal. Concordant (high perfusion correlate) participants had an 85% rate of successful completion, while discordant participants had a 15% rate of successful completion. Twenty-five percent of dropouts and 50% of participants removed were discordant (low perfusion correlate), while only 25% of those who completed were discordant. Failure to complete the trial was not explained by depression, craving, benzoylecgonine levels or quantitative electroencephalogram (QEEG) power; thus cordance may help identify attrition risk.
authors.affiliation: Medication Development Unit, Research Service, and Psychiatry Service, West Los Angeles VA Medical Center, California, USA. VennemanS@uhv.edu
authors.forename: Sandy
authors.initials: S
authors.lastname: Venneman
authors.forename: Andrew
authors.initials: A
authors.lastname: Leuchter
authors.forename: George
authors.initials: G
authors.lastname: Bartzokis
authors.forename: Mace
authors.initials: M
authors.lastname: Beckson
authors.forename: Sara L
authors.initials: SL
authors.lastname: Simon
authors.forename: Melodie
authors.initials: M
authors.lastname: Schaefer
authors.forename: Richard
authors.initials: R
authors.lastname: Rawson
authors.forename: Tom
authors.initials: T
authors.lastname: Newton
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cook
authors.forename: Sebastian
authors.initials: S
authors.lastname: Uijtdehaage
authors.forename: Walter
authors.initials: W
authors.lastname: Ling
mesh_terms: D000328:Adult; D000465:Algorithms; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage; D018696:Neuroprotective Agents / Q000008:administration & dosage; D010352:Patient Dropouts / Q000523:psychology / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography; D018570:Risk Assessment; D012642:Selegiline / Q000008:administration & dosage; D012815:Signal Processing, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D012642:Selegiline