[Protection of soybean isoflavones to Abeta1-42 induced toxic on PC12 cell].
OBJECTIVE
To explore the effects of the soybean isoflalones to Abeta1-42 induced toxic on PC12 Cell.


METHODS
the cell culture PC12 were exposed to 10 micromol/L Abeta1-42 for 24h pertreat with soybean isoflavones for 2hs. The morphololycal and survival of PC12 were observed by MTT.


RESULTS
The survival rate of PC12 were decreased after treatment of soybean isoflavones and reshape the morphological of cell.


CONCLUSIONS
Soybean isoflavone has protective effects on PC12 cell.
Zhao
Yu-Hong
YH
Guangdong Pharmaceutical College, Guangzhou 510315, China.
D000544:Alzheimer Disease / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D016716:PC12 Cells; D010446:Peptide Fragments / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013025:Glycine max / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D016229:Amyloid beta-Peptides; D007529:Isoflavones; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D010936:Plant Extracts; C075222:amyloid beta-protein (1-42); D004958:Estradiol