The genetics of Salmonella genomic island 1.
Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104, resistant to ampicillin, chloramphenicol/florfenicol, streptomycin, sulfonamides, and tetracycline, has disseminated worldwide. The resistance genes reside on the 43-kb Salmonella genomic island 1 (SGI1), which is transferable. Drug-resistant variants of SGI1 have been identified in numerous serotypes. Strains harboring SGI1 may be more virulent and have a tendency to rapidly disseminate.
Mulvey
Michael R
MR
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada. michael_mulvey@phac-aspc.gc.ca
Boyd
David A
DA
Olson
Adam B
AB
Doublet
Benoît
B
Cloeckaert
Axel
A
D000818:Animals; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000235:genetics*; D006801:Humans; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000453:epidemiology / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence