Psammomatous choroid plexus papilloma: three cases with atypical characteristics.
BACKGROUND
Intravertricular papillary neoplasms are derived from choroid plexus epithelium. Although choroid plexus tumors account for 0.4% to 0.6% of all brain tumors, they represent 2% to 4%. Approximately 80% of choroid plexus carcinomas arise in children.


METHODS
We describe 3 cases of choroid plexus papilloma (CPP) with profuse psammomatous bodies and calcifications that have lost their normal papillary architecture. Immunohistochemistry was positive for glial fibrillary acidic protein in 2 cases, and proliferating cellular nuclear antigen index was higher compared with regular CPPs. All 3 patients were female and were 12, 40, and 48 years old, respectively.


CONCLUSIONS
We describe psammomatous CPPs and suggest a difference from CPPs because of the more aggressive clinical course, and higher nuclear proliferation index (proliferating cellular nuclear antigen) than the CPPs that lack psammoma bodies.
Tena-Suck
Martha Lilia
ML
Departament of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico 14269. tenasuck@yahoo.com
López-Gómez
Mario
M
Salinas-Lara
Citlaltepelt
C
Arce-Arellano
Rosa Isela
RI
Biol
Aurora Sánchez
AS
Renbao-Bojorquez
Daniel
D
D000328:Adult; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D003399:Craniotomy; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008875:Middle Aged; D019635:Neurosurgical Procedures; D020288:Papilloma, Choroid Plexus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011183:Postoperative Complications; D014057:Tomography, X-Ray Computed