title: Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors.
abstract: Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
authors.forename: Uma
authors.initials: U
authors.lastname: Siripurapu
authors.forename: Renata
authors.initials: R
authors.lastname: Kolanos
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dukat
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
mesh_terms: D000840:Anisoles / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D002227:Carbazoles / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D013424:Sulfanilamides / Q000737:chemistry*
chemical_list: D000840:Anisoles; D002227:Carbazoles; D007211:Indoles; D011985:Receptors, Serotonin; D013424:Sulfanilamides; C097216:serotonin 6 receptor; C409925:1,2,3,4-tetrahydrocarbazole; C060998:anisole