title: Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India.
abstract: Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).
authors.affiliation: The Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom.
authors.forename: Satheesh
authors.initials: S
authors.lastname: Nair
authors.forename: Madhulika
authors.initials: M
authors.lastname: Unnikrishnan
authors.forename: Keith
authors.initials: K
authors.lastname: Turner
authors.forename: Subash Chandra
authors.initials: SC
authors.lastname: Parija
authors.forename: Carol
authors.initials: C
authors.lastname: Churcher
authors.forename: John
authors.initials: J
authors.lastname: Wain
authors.forename: Narasimha
authors.initials: N
authors.lastname: Harish
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D007194:India; D009154:Mutation; D012482:Salmonella paratyphi A / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase