Analgesic activity of leaf extracts of Culcasia scandens P. Beauv.
Analgesic activity of methanol leaf extract of C. scandens obtained by column chromatography and its graded solvent fractions, was evaluated in mice using acetic acid-induced abdominal writhing and formalin-induced paw licking. The extract and fractions significantly inhibited abdominal writhing and two phases of formalin-induced paw licking in mice, indicating that antinociceptive activity may involve inhibition of pain by peripheral and central mechanisms.
Okoli
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Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka Enugu State, Nigeria. charlesokoli@hotmail.com
Akah
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Egbuniwe
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D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D029064:Araceae / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
D000700:Analgesics; D010936:Plant Extracts