title: Effect of ascorbic acid supplementation on certain oxidative stress parameters in the post reperfusion patients of myocardial infarction.
abstract: Reperfusion injury causes oxidative stress thereby resulting in an imbalance between oxidant-antioxidant systems. In the present communication, the effect of ascorbic acid supplementation has been studied on certain oxidant and antioxidant parameters in the blood of the patients with myocardial infarction before and after thrombolysis. In patients after thrombolysis, the activity of antioxidant enzyme, superoxide dismutase, in the blood was found to be significantly reduced where as the activity of the oxidant enzyme, xanthine oxidase, was found to be significantly increased. Malondialdehyde levels, the index of free radical mediated damage, was also found to be significantly elevated in thrombolysed patients compared to the patients before thrombolysis. Supplementation of vitamin C to the post reperfusion patients restored these parameters back to normal or near normal levels.
authors.affiliation: Department of Biochemistry, Lucknow University, Lucknow 226007, India.
authors.forename: Pushpa
authors.initials: P
authors.lastname: Bhakuni
authors.forename: M
authors.initials: M
authors.lastname: Chandra
authors.forename: M K
authors.initials: MK
authors.lastname: Misra
mesh_terms: D001205:Ascorbic Acid / Q000627:therapeutic use*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology*; D015425:Myocardial Reperfusion; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015424:Reperfusion; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D001205:Ascorbic Acid