A highly stereocontrolled total synthesis of (-)-neodysiherbaine A.
Neodysiherbaine A, a neuroexitotoxin occurring in a Micronesian marine sponge Dysidea herbacea, was synthesized from tri-O-acetyl-D-glucal with excellent stereocontrol. The method established enables us to obtain gram quantities of neodysiherbaine A and its related compounds.
Takahashi
Keisuke
K
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.
Matsumura
Takashi
T
Corbin
Graeme R M
GR
Ishihara
Jun
J
Hatakeyama
Susumi
S
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D047088:Dysidea / Q000737:chemistry; D015394:Molecular Structure
D019086:Bridged Bicyclo Compounds, Heterocyclic; C438974:neodysiherbaine A; D000409:Alanine