title: Pharmacological activity of three commercial Hypericum perforatum preparations in mice.
abstract: St John's Wort (Hypericum perforatum) is the main herbal species used to treat depression. The products available on the pharmaceutical and dietary supplement markets are obtained by a variety of preparation processes and their pharmacological effects may differ significantly. The purpose of this study therefore was to investigate the effect of different St John's Wort commercial preparations available on the French market. Only one preparation gave significant results in the forced swimming test.
authors.affiliation: Institut des Substances Végétales, 283 rue de la Chaussade, 63270 Vic-le-Comte, France. daniel@isv-fr.com
authors.forename: D
authors.initials: D
authors.lastname: Jean
authors.forename: M
authors.initials: M
authors.lastname: Pouligon
authors.forename: A C
authors.initials: AC
authors.lastname: Henriot
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects*; D020902:Hypericum; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D013550:Swimming
chemical_list: D010936:Plant Extracts