[Case report of repeated acetaminophen overdosing with various symptoms].
A 32-yr-old woman with acute gastritis and migraine used Naron commonly (the principal ingredients are acetaminophen and bromvalerylurea) and had been taking about 3g of acetaminophen daily for several days before admission. She was hospitalized with severe diffuse abdominal pain. On physical examination she had a peritoneal sign and laboratory studies showed elevated liver enzymes, hypophosphatemia, hypokalemia and low blood urea nitrogen(BUN). Serum acetaminophen level was 5.5 microg/mL on admission, so she seemed to be suffered from not only single ingestion but also repeated overdosing. Although we needed for aggressive phosphate and potassium repletion for about a week, all symptoms were distinguished after she quitted acetaminophen ingestion. In addition to hepatic dysfunction, renal failure and disseminated intravascular coagulopathy, we should pay attention to various symptoms like in this case when treating for a acetaminophen poisoning.
Kojima
Naoki
N
Department of Intensive Care and Emergency Medicine, Showa General Hospital.
Ishida
Jyunnrou
J
Inagawa
Hiroshi
H
Okada
Yasusei
Y
Machida
Michirou
M
Terada
Taizou
T
D015746:Abdominal Pain / Q000139:chemically induced; D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D017674:Hypophosphatemia / Q000139:chemically induced; D012008:Recurrence; D051437:Renal Insufficiency / Q000139:chemically induced*
D000082:Acetaminophen