title: Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET).
abstract: The aim of the study was to test an association between polymorphisms of genes connected with dopaminergic inactivation in prefrontal cortex [catechol-O-methyltransferase (COMT), dopamine transporter (DAT), norepinephrine transporter (NET)], and performance on the Wisconsin Card Sorting Test (WCST), in schizophrenic patients. The number of perseverative errors (WCST-P), non-perseverative errors (WCST-NP), completed corrected categories (WCST-CC), conceptual level responses (WCST-%CONC) and set to the first category (WCST-1st CAT) were measured. Genotyping was done for the Val108(158)Met polymorphism of the COMT gene (79 patients), the 3'UTR VNTR polymorphism of the DAT gene (124 patients) and the 1287 A/G polymorphism of the NET gene (63 patients). Male schizophrenic patients with Val/Val genotype of COMT obtained better results on WCST-P, while female patients had worse results on the WCST-NP compared with the remaining genotypes. There was a slight trend for patients with the A9/A9 genotype of DAT and with the A/A genotype of NET to perform better on some domains of the WCST, compared with other genotypes. A limitation to the interpretation of results could be small number of patients studied as well as variable psychopathological state and medication during cognitive testing.
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, ul.Szpitalna 27/33, 60-572 Poznan, Poland. rybakows@wlkp.top.pl
authors.forename: Janusz K
authors.initials: JK
authors.lastname: Rybakowski
authors.forename: Alina
authors.initials: A
authors.lastname: Borkowska
authors.forename: Piotr M
authors.initials: PM
authors.lastname: Czerski
authors.forename: Monika
authors.initials: M
authors.lastname: Dmitrzak-Weglarz
authors.forename: Maria
authors.initials: M
authors.lastname: Skibinska
authors.forename: Pawel
authors.initials: P
authors.lastname: Kapelski
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009638:Norepinephrine / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase; D009638:Norepinephrine