title: Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor.
abstract: The development of cancerous cells from the normal cells is the consequence of multiple genetic and epigenetic abuses. Activation of "Angiogenic switch" or formation of new blood vessels is one of the upshots of these abuses. Multiple factors are associated with the activation of angiogenic switch. Vascular endothelial growth factor (VEGF) and its down stream signaling molecules is important troupe of this event. In this article, we reviewed the role this troupe in the development of Barrett's adenocarcinoma and also discussed the possible remedies, which have the impact on blocking the function of this troupe.
authors.affiliation: Department of Zoology, K.C. College, Hetampur, Birbhum, West Bengal, India.
authors.forename: Aminul
authors.initials: A
authors.lastname: Islam
authors.forename: Swarnali
authors.initials: S
authors.lastname: Banerjee
authors.forename: Suman
authors.initials: S
authors.lastname: Kambhampati
authors.forename: Joaquina
authors.initials: J
authors.lastname: Baranda
authors.forename: Snigdha
authors.initials: S
authors.lastname: Banerjee
authors.forename: Allan P
authors.initials: AP
authors.lastname: Weston
authors.forename: Neela K
authors.initials: NK
authors.lastname: Saxena
authors.forename: Sushanta K
authors.initials: SK
authors.lastname: Banerjee
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000503:physiopathology*; D017398:Alternative Splicing; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000188:drug therapy / Q000503:physiopathology*; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology*
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor