title: Magnetic resonance imaging and pathologic findings associated with necrotizing encephalitis in two Yorkshire terriers.
abstract: Two young adult Yorkshire terriers had neurologic signs consistent with forebrain and brainstem involvement or forebrain involvement alone. On magnetic resonance imaging studies there were asymmetric bilateral lesions mainly in the cerebral cortex, and in the diencephalon. These areas were hyperintense on T2-weighted and FLAIR images, but hypointense or isointense on T1-weighted images. Lesions had a varying degree of contrast enhancement. Areas which were isointense on T1-weighted images had no contrast enhancement or only foci of contrast enhancement. Lesions with hypointensity in T1-weighted images had no enhancement or more frequently ring-like enhancement around the lesion. Necrotizing encephalitis was confirmed pathohistologically in both dogs. The degree of contrast enhancement appeared to be related to the degree of lymphohistiocytic inflammation on histologic examination.
authors.affiliation: Department of Small Animal Medicine, University of Leipzig, An den Tierkliniken 23, 04103 Leipzig, Germany.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: von Praun
authors.forename: Kaspar
authors.initials: K
authors.lastname: Matiasek
authors.forename: Vera
authors.initials: V
authors.lastname: Grevel
authors.forename: Michaele
authors.initials: M
authors.lastname: Alef
authors.forename: Thomas
authors.initials: T
authors.lastname: Flegel
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D010375:Pedigree