title: Plasma and erythrocyte phospholipid fatty acids composition in Serbian hemodialyzed patients.
abstract: Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p < 0.001), total cholesterol (p < 0.05), and total phospholipids (p < 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p < 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p < 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p < 0.01) higher level of oleic (18:1 n-9) and lower levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p < 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p < 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p < 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients.
authors.affiliation: Institute for Medical Research, Laboratory for Nutrition and Metabolism, Belgrade, Serbia and Montenegro.
authors.forename: Vanja
authors.initials: V
authors.lastname: Ristić
authors.forename: Vesna
authors.initials: V
authors.lastname: Tepsić
authors.forename: Danijela
authors.initials: D
authors.lastname: Ristić-Medié
authors.forename: Gordana
authors.initials: G
authors.lastname: Perunicić
authors.forename: Zorica
authors.initials: Z
authors.lastname: Rasić
authors.forename: Marija
authors.initials: M
authors.lastname: Postić
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arsić
authors.forename: Vera
authors.initials: V
authors.lastname: Blazencić-Mladenović
authors.forename: Gordana
authors.initials: G
authors.lastname: Ristić
mesh_terms: D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis* / Q000097:blood; D006435:Renal Dialysis; D015022:Yugoslavia
chemical_list: D005227:Fatty Acids; D010743:Phospholipids