title: Anti-aging peptide bioregulators induce reactivation of chromatin.
abstract: The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people. The data obtained indicate that epitalon, livagen and vilon: 1) activate synthetic processes, caused by reactivation of ribosomal genes as a result of deheterochromatinization (decondensation) of nucleolus organizer regions; 2) induce unrolling (deheterochromatinization) of total heterochromatin; 3) release genes repressed by heterochromatinization (condensation) of euchromatic regions forming facultative heterochromatin; 4) epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9. However, vilon does not induce deheterochromatinization of pericentromeric structural heterochromatin. These results indicate that peptide bioregulators Epitalon, Livagen and Vilon cause activation (deheterochromatinization) of chromatin in lymphocytes of old individuals.
authors.affiliation: Tbilisi State University.
authors.forename: T
authors.initials: T
authors.lastname: Lezhava
authors.forename: J
authors.initials: J
authors.lastname: Monaselidze
authors.forename: T
authors.initials: T
authors.lastname: Kadotani
authors.forename: N
authors.initials: N
authors.lastname: Dvalishvili
authors.forename: T
authors.initials: T
authors.lastname: Buadze
mesh_terms: D000375:Aging / Q000187:drug effects*; D001673:Biodegradation, Environmental / Q000187:drug effects; D002843:Chromatin / Q000378:metabolism*; D004151:Dipeptides / Q000494:pharmacology*; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*
chemical_list: D002843:Chromatin; D004151:Dipeptides; C473185:Livagen; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine