title: Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.
abstract: Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
authors.affiliation: Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia. a.bauskin@cfi.unsw.edu.au
authors.forename: Asne R
authors.initials: AR
authors.lastname: Bauskin
authors.forename: David A
authors.initials: DA
authors.lastname: Brown
authors.forename: Tamara
authors.initials: T
authors.lastname: Kuffner
authors.forename: Heiko
authors.initials: H
authors.lastname: Johnen
authors.forename: X Wei
authors.initials: XW
authors.lastname: Luo
authors.forename: Mark
authors.initials: M
authors.lastname: Hunter
authors.forename: Samuel N
authors.initials: SN
authors.lastname: Breit
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D055436:Growth Differentiation Factor 15; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15