title: The therapeutic potential of Angiotensin-(1-7) as a novel Renin-Angiotensin System mediator.
abstract: In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2-Angiotensin-(1-7)-Mas axis.
authors.affiliation: Departamento de Pediatria, Faculdade de Medicina-UFMG, Av. Alfredo Balena, 190, Belo Horizonte, MG, 30130-100, Brazil. acssilva@hotmail.com
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões e Silva
authors.forename: Sérgio Veloso Brant
authors.initials: SV
authors.lastname: Pinheiro
authors.forename: Regina Maria
authors.initials: RM
authors.lastname: Pereira
authors.forename: Anderson José
authors.initials: AJ
authors.lastname: Ferreira
authors.forename: Robson Augusto Souza
authors.initials: RA
authors.lastname: Santos
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D005837:Genitalia, Male / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7)