Oral focal epithelial hyperplasia: report of five cases.
Focal epithelial hyperplasia or Heck's disease is a rare contagious disease caused by human papillomavirus types 13 or 32, initially described among Native American populations. This condition is characterized by the occurrence of multiple small papules or nodules in oral cavity, especially on labial and buccal mucosa and tongue. This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing.
Borborema-Santos
Cristina Maria
CM
Center of Multidisciplinary Support, Federal University of Amazonas, Manaus, AM, Brazil. crisantos@ufam.edu.br
Castro
Maria Marta de
MM
Santos
Paulo José Benevides dos
PJ
Talhari
Sinésio
S
Astolfi-Filho
Spartaco
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000821:virology*; D006801:Humans; D007199:Indians, South American; D008297:Male; D009061:Mouth Mucosa / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA