title: Prognostic significance of clinical and immunological parameters in diffuse large B-cell lymphomas.
abstract: The aim of the study was to evaluate influence of CD10 expression on overall survival with risk factors according of the IPI. CD10 expression was evaluated in 45 patients with diagnosis of Diffuse large B-cell lymphomas. Unfavorable parameters of the International prognostic index (IPI) were compared in the CD10 positive and CD10 negative groups, number of unfavorable clinical findings in CD10 positive and CD10 negative cases were similar at diagnosis. The study revealed that the CD10 antigen expression is an unfavorable prognostic factor in the high and high-intermediate risk groups regarding to the IPI, overall survival is shorter in the CD10 positive cases and was 14,1 month compared with 23,5 month in CD10 negative group(p<0,01). CD10 antigen expression may have importance as one of the prognostic factors in patients with diagnosis of diffuse large B-cell lymphomas. Interestingly, that influence of CD10 expression on overall survival in the low and low-intermediate risk groups (IPI) wasn't revealed (p>0,05).
authors.affiliation: Department of Hematology and Transfusiology, State Medical Academy, Tbilisi, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Tsartsidze
authors.forename: M
authors.initials: M
authors.lastname: Betaneli
mesh_terms: D000328:Adult; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D009367:Neoplasm Staging; D015260:Neprilysin / Q000276:immunology*
chemical_list: D015260:Neprilysin