X-ray structure of influenza virus NS1 effector domain.
The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.
Bornholdt
Zachary A
ZA
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Prasad
B V Venkataram
BV
D018360:Crystallography, X-Ray; D053124:Influenza A Virus, H5N1 Subtype / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D017361:Viral Nonstructural Proteins / Q000737:chemistry*
C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins