Antioxidative actions of statins: potential mechanisms for antiathersclerotic effects.
Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.
Watanabe
Takanori
T
Department of Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Yasunari
Kenichi
K
Nakamura
Munehoro
M
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D015394:Molecular Structure
D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors