title: A randomized open-label comparison of the impact of olanzapine versus risperidone on sexual functioning.
abstract: The objective of this study was to compare sexual functioning in patients treated with olanzapine or risperidone. This open-label trial included 46 patients randomized to olanzapine (5-15 mg/d) or risperidone (1-6 mg/d) for 6 weeks. We used sexual dysfunction was assessed by a semistructured interview based on the items of the UKU side effect rating scale. Three olanzapine-treated patients (12.0%), compared with 11 risperidone-treated patients (52.4%), reported sexual dysfunctions (p = .008) in the semistructured interview. Only 4 patients (8.7%) spontaneously reported sexual dysfunction. The mean dose was 9.4 mg/d for olanzapine and 3.4 mg/d for risperidone. The mean (+/-SD) prolactin levels (ng/mL) in olanzapine-and risperidone-treated patients were 25.1 (+/- 23.5) and 43.5 (+/- 26.1), respectively. Less sexual dysfunction occurred in the group treated with olanzapine compared with the risperidone group. Direct questioning about sexual functioning is necessary to avoid underestimating the frequency of sexual side effects in patients with schizophrenia and related psychotic disorders.
authors.affiliation: Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands. h.knegtering@psy.umcg.nl
authors.forename: H
authors.initials: H
authors.lastname: Knegtering
authors.forename: Marco
authors.initials: M
authors.lastname: Boks
authors.forename: Carl
authors.initials: C
authors.lastname: Blijd
authors.forename: Stynke
authors.initials: S
authors.lastname: Castelein
authors.forename: Robert J
authors.initials: RJ
authors.lastname: van den Bosch
authors.forename: Durk
authors.initials: D
authors.lastname: Wiersma
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D000077152:Olanzapine; D011388:Prolactin / Q000097:blood; D011618:Psychotic Disorders / Q000188:drug therapy; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D011388:Prolactin; D018967:Risperidone; D000077152:Olanzapine