Effects of aspirin and mefenamic acid on soman poisoning-induced neuropathology in mice.
The efficacy of aspirin and mefenamic acid to counteract soman-induced brain damage was investigated in mice. Neuronal damage was evaluated in the hippocampus and amygdala by performing omega3 receptor density measurements and hemalun-phloxin staining. The effect of both drugs on the proliferation of neural progenitors after soman exposure was also assessed. Mefenamic acid aggravated the soman-induced hippocampal neuropathology. On the other hand, aspirin recorded a weak neuroprotective effect in the amygdala. However, this drug also diminished the proliferation of neural precursor cells. The possible neurochemical mechanisms underlying such differences in the efficacy of the two drugs are also reviewed.
Collombet
Jean-Marc
JM
Département de Toxicologie, CRSSA, La Tronche, France. jmcollombet@crssa.net
Baubichon
Dominique
D
Masqueliez
Catherine
C
Bernabé
Denis
D
Four
Elise
E
Burckhart
Marie-France
MF
Lallement
Guy
G
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects; D002619:Chemical Warfare Agents / Q000506:poisoning*; D004359:Drug Therapy, Combination; D007279:Injections, Subcutaneous; D008297:Male; D008528:Mefenamic Acid / Q000627:therapeutic use*; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012999:Soman / Q000506:poisoning*; D013234:Stem Cells / Q000187:drug effects / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002619:Chemical Warfare Agents; D018696:Neuroprotective Agents; D008528:Mefenamic Acid; D012999:Soman; D001241:Aspirin