Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.
An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.
Germano
Giuseppe
G
Laboratory of Pediatric Onco-Hematology, Department of Pediatrics, University Hospital of Padua, Padua, Italy.
Pigazzi
Martina
M
del Giudice
Laura
L
Campo Dell'Orto
Marta
M
Spinelli
Monica
M
Zangrando
Andrea
A
Paolucci
Paolo
P
Ladogana
Saverio
S
Basso
Giuseppe
G
D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D019070:Cell Lineage; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics / Q000648:ultrastructure; D002999:Clone Cells / Q000473:pathology; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D015321:Gene Rearrangement; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D011495:Histone-Lysine N-Methyltransferase; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008954:Models, Biological; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D014178:Translocation, Genetic; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D018398:Homeodomain Proteins; C497422:KMT2A protein, human; C113855:MLL-AF4 fusion protein, human; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C097899:homeobox protein HOXA9; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3