title: Low ligand loading, highly enantioselective addition of phenylacetylene to aromatic ketones catalyzed by Schiff-base amino alcohols.
abstract: [reaction: see text] Schiff-base amino alcohols 7a,b derived from L-phenylglycine through three simple steps are found to be highly effective for the enantioselective addition of phenylacetylene to aromatic ketones. When the loading of 7b was 1 mol %, an ee value of up to 95% was obtained. However, when 7b was lowered to 0.1 mol %, a high ee value of 85% was still achieved. A practical solution to synthesize the optically active tertiary propargylic alcohols was described.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Gansu, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.forename: Zhao-Qing
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang