title: [Association of human histocompatibility antigens with ophthalmological disorders].
abstract: Many studies have been trying to identify genetic markers for ophthalmological diseases, including, among others, the HLA (Human Leukocyte Antigens). Localized on the short arm of chromosome 6, the human leukocyte antigen system is well known for its capacity to confer susceptibility or resistance to different diseases. In view of its accentuated polymorphism, the strength and type of association differs with the disease and sometimes, with the studied ethnic-racial group. The development of molecular methods to typify HLA alleles and recent updates of their nomenclature has contributed to a better understanding of this system. In this review, some aspects of the human leukocyte antigen system are discussed, such as the methods of detection, nomenclature and association with acute anterior uveitis, ocular cicatricial pemphigoid, young-onset keratoconus and birdshot retinochoroidopathy.
authors.affiliation: Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil. cresio.alves@uol.com.br
authors.forename: Crésio
authors.initials: C
authors.lastname: Alves
authors.forename: Isadora
authors.initials: I
authors.lastname: Meyer
authors.forename: Maria Betânia Pereira
authors.initials: MB
authors.lastname: Toralles
authors.forename: Roberto Lorens
authors.initials: RL
authors.lastname: Marback
mesh_terms: D000483:Alleles; D005128:Eye Diseases / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D006801:Humans; D012164:Retinal Diseases / Q000235:genetics / Q000276:immunology; D015866:Uveitis, Posterior / Q000235:genetics / Q000276:immunology
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II