[Activity of angiotensin converting enzyme in blood serum of patients with stable effort angina].
OBJECTIVE
To study activity of angiotensin converting enzyme (ACE) in blood serum of patients with stable effort angina.


METHODS
ACE activity was measured in 11 patients (age 35-45, mean 46.5+/-1.6 years) with typical class II-III effort angina without hypertension or contractile insufficiency of the myocardium previously not treated with ACE inhibitors. Diagnosis was verified by angiography (7 patients), data of 24 hour ECG monitoring and exercise tests. Control group comprised 13 practically healthy subjects (age 36-54, mean 48.3+/-2.09 years).


RESULTS
ACE activity in controls was 32.5-57 micromol/min/l (mean 46.2+/-2.0 micromol/min/l), in patients -- 48-110 micromol/min/l (mean 73.5+/-5.9 micromol/min/l), p<0.001. More than 2/3 of patients (7 of 11) had ACE activity above upper limit of norm.
Ganelina
I E
IE
Nikolaeva
E P
EP
Skverchinskaia
E A
EA
D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis / Q000201:enzymology* / Q000503:physiopathology*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D005082:Physical Exertion
D007703:Peptidyl-Dipeptidase A