The growth factor independence-1 transcription factor: new functions and new insights.
The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood. Patients with mutations in Gfi1 exhibit severe congenital neutropenia (SCN) or non-immune chronic idiopathic neutropenia of adults. Gfi1 was initially described as an oncoprotein that mediates tumor progression in a mouse model of leukemia; however, recent data suggest that Gfi1 may act as either an oncogene or an anti-proliferative tumor suppressor gene depending on the cell type. Here we review the latest literature on Gfi1, and emphasize its role in the hematopoietic, sensory and neuroendocrine systems.
Kazanjian
Avedis
A
Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Gross
Eleanore A
EA
Grimes
H Leighton
HL
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D051379:Mice; D009475:Neurons, Afferent / Q000378:metabolism; D009490:Neurosecretory Systems / Q000378:metabolism; D009503:Neutropenia / Q000235:genetics / Q000378:metabolism; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D009928:Organ Specificity; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; C498275:GFI1 protein, human; C079873:Gfi1 protein, mouse; D015513:Oncogene Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins