Botulinum toxin injections to reduce adiposity: possibility, or fat chance?
Obese individuals often suffer from negative self-image. Many, even those with a normal body mass index, resort to pharmacotherapy (lipase inhibitors or appetite suppressants), mesotherapy and surgery (gastric volume reduction, liposuction or apronectomy) in a bid to remove excess adipose tissue. These treatments are associated with inherent morbidity and even mortality, and hence should not be undertaken lightly. The observation that denervation of adipose tissue results in lipoatrophy leads us to postulate that chemodenervation using botulinum toxin may achieve the same result, i.e. fat loss, and we explore the methods by which selective fat loss may be achieved. We concede that removal of subcutaneous fat does not, however, reduce the risks associated with the metabolic syndrome, as visceral (intra-abdominal) fat is not reduced by the removal of subcutaneous fat.
Lim
Erle C H
EC
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Seet
Raymond C S
RC
D000273:Adipose Tissue / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D003014:Clostridium botulinum; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D006801:Humans; D007267:Injections; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D051381:Rats; D014628:Vagotomy
D001905:Botulinum Toxins