Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia.
A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5' part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression.
Berger
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EMI 0210 Inserm, Tour Pasteur, Hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75743 Paris cedex 15, France. berger@necker.fr
Bernard
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OA
D002648:Child; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics* / Q000648:ultrastructure; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics* / Q000648:ultrastructure; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053646:Interleukin-2 Receptor beta Subunit / Q000096:biosynthesis / Q000235:genetics*; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D014178:Translocation, Genetic
D053646:Interleukin-2 Receptor beta Subunit; D009363:Neoplasm Proteins