[Rhabdomyolysis induced by fenofibrate monotherapy].
BACKGROUND
Rhabdomyolysis with fibrate have been reported when fibrate are associated with statin or during renal insufficiency or hypothyroidism.


METHODS
We describe one patient with diabetes mellitus treated by fenofibrate monotherapy since several years; 48 h after gliclazide therapy was introduced, rhabdomyolysis occurred.


CONCLUSIONS
Responsibilities of deshydratation and / or drug interaction with gliclazide. are discussed.
Archambeaud-Mouveroux
F
F
Service de Médecine Interne B-d'Endocrinologie, Hôpital du Cluzeau, 23, avenue Dominique-Larrey, 87042 Limoges, France. francoise.archambeaud@chu-limoges.fr
Lopez
S
S
Combes
C
C
Lassandre
S
S
Amaniou
M
M
Teissier
M-P
MP
Galinat
S
S
D003920:Diabetes Mellitus / Q000188:drug therapy; D004347:Drug Interactions; D050171:Dyslipidemias / Q000188:drug therapy; D011345:Fenofibrate / Q000009:adverse effects*; D005500:Follow-Up Studies; D005907:Gliclazide / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced*
D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D005907:Gliclazide; D011345:Fenofibrate