New, general, and practical enamine cyclopropanation using dichloromethane.
[reaction: see text] Dichloromethane serves as a novel electrophilic carbene equivalent which adds to an enamine double bond. The presence of other alkene moieties in the enamine partner is well tolerated. Even enamines derived from sterically hindered ketones react readily with dichloromethane promoted by TiCl(4)-Mg.
Tsai
Chia-Chung
CC
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, Republic of China.
Hsieh
I-Lin
IL
Cheng
Tsung-Ting
TT
Tsai
Ping-Kuei
PK
Lin
Kuo-Wei
KW
Yan
Tu-Hsin
TH