title: [A case of hepatoid carcinoma of the pancreas].
abstract: Hepatoid carcinoma is a primary extrahepatic neoplasm exhibiting features of hepatocellular carcinoma (HCC) in terms of morphology, immunohistochemistry, and behavior. In many cases, tumor cytoplasm is positive for alpha- fetoprotein (alpha-FP) with elevated serum alpha-FP level. Because not all hepatoid carcinomas are associated with alpha- FP overproduction, diagnosis should be made essentially by histological features of the tumor. We present a case of hepatoid carcinoma of the pancreas in a 21-year-old male patient. Abdominal computed tomography and magnetic resonance imaging revealed an inhomogeneously enhanced pancreatic head mass. Serum alpha-FP level was markedly elevated. He underwent pylorus-preserving Whipple's operation. The tumor showed hepatoid and neuroendocrine components simultaneously. The histopathological diagnosis was hepatoid carcinoma associated with neuroendocrine tumor of the pancreas. Seven months after the surgery, the patient is healthy without evidence of recurrence. To date, only 7 cases of hepatoid carcinoma of the pancreas have been reported in the literature, and this is the first case report in Korea.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Hyun Jong
authors.initials: HJ
authors.lastname: Oh
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Cheung
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Kim
authors.forename: Soon Sub
authors.initials: SS
authors.lastname: Kim
authors.forename: Myoung Seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Soo Heon
authors.initials: SH
authors.lastname: Park
authors.forename: Joon Yeol
authors.initials: JY
authors.lastname: Han
authors.forename: Nam Ik
authors.initials: NI
authors.lastname: Han
authors.forename: Jae Kwang
authors.initials: JK
authors.lastname: Kim
authors.forename: Young Sok
authors.initials: YS
authors.lastname: Lee
authors.forename: Eung Kook
authors.initials: EK
authors.lastname: Kim
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Jung
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology