Twenty years of clinical islet transplantation at the Diabetes Research Institute--University of Miami.
Transplantation of allogeneic pancreatic islets for the treatment of patients with Type 1 diabetes mellitus (T1DM) is now a reality. The steady progress that has allowed for the recent successful clinical trials world-wide follows a steep learning curve and the perseverance of the international islet transplantation community. The Clinical Islet Transplant Program at the Diabetes Research Institute - University of Miami has contributed to the progress in the field with a 20-year track record. It has been a long journey and despite the intermediate success, more work is needed in order to achieve the ultimate goal of a safe and long-lasting treatment for patients with T1DM.
Pileggi
Antonello
A
Clinical Islet Transplant Program and Cell Transplant Center, Diabetes Research Institute, University of Miami, Leonard Miller School of Medicine, Miami, Florida, USA.
Ricordi
Camillo
C
Kenyon
Norma S
NS
Froud
Tatiana
T
Baidal
David A
DA
Kahn
Aisha
A
Selvaggi
Gennaro
G
Alejandro
Rodolfo
R
D000047:Academies and Institutes; D001854:Bone Marrow Cells / Q000166:cytology; D002469:Cell Separation / Q000379:methods; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000601:surgery; D005431:Florida; D006085:Graft Survival; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016381:Islets of Langerhans Transplantation / Q000266:history / Q000379:methods / Q000639:trends*; D018579:Patient Selection; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods