title: [Thrombolysis in cardiac arrest].
abstract: Both acute myocardial infarction and pulmonary thromboembolism are responsible for a great number of cardiac arrests. Both present high rates of mortality. Thrombolysis has proved to be an effective treatment for acute myocardial infarction and pulmonary thromboembolism with shock. It would be worth considering whether thrombolysis could be effective and safe during or after cardiopulmonary resuscitation (CPR). Unfortunately, too few clinical studies presenting sufficient scientific data exist in order to respond adequately to this question. However, most studies they show that thrombolysis applied during and after CPR is a therapeutic option that is not associated with greater risk of serious hemorrhaging and could possibly have beneficial effects. On the other hand, experimental data exists which show that thrombolytics can attenuate neurological damage produced after CPR. Nevertheless, clinical trials would be necessary in order to adequately establish the effectiveness and safety of thrombolysis in patients who require CPR.
authors.affiliation: Unidad de Medicina Intensiva, Servicio de Cuidados Criticos y Urgencias, Hospital Universitario Médico-Quirúrgico, Complejo Hospitalario de Jaén, Jaén, España. ruizbailen@telefonica.net
authors.forename: M
authors.initials: M
authors.lastname: Ruiz Bailén
authors.forename: L
authors.initials: L
authors.lastname: Rucabado Aguilar
authors.forename: A
authors.initials: A
authors.lastname: Morante Valle
authors.forename: A
authors.initials: A
authors.lastname: Castillo Rivera
mesh_terms: D016887:Cardiopulmonary Resuscitation; D006323:Heart Arrest / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy; D011655:Pulmonary Embolism / Q000150:complications / Q000628:therapy; D015912:Thrombolytic Therapy