title: Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content.
abstract: The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease of the mtDNA content occurs with aging in liver and soleus muscle, whereas there is no age-related significant change of mtDNA content in brain. CR fully reverses the age-dependent loss of mtDNA in liver and soleus, whereas it results in a significant increase of mtDNA amount above the value of aged ad libitum fed rats in brain. These results further support the tissue-specific effect of CR, likely because of the different dependence of tissues on external nutrient uptake.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy. p.cassano@biologia.uniba.it
authors.forename: P
authors.initials: P
authors.lastname: Cassano
authors.forename: A G
authors.initials: AG
authors.lastname: Sciancalepore
authors.forename: A M S
authors.initials: AM
authors.lastname: Lezza
authors.forename: C
authors.initials: C
authors.lastname: Leeuwenburgh
authors.forename: P
authors.initials: P
authors.lastname: Cantatore
authors.forename: M N
authors.initials: MN
authors.lastname: Gadaleta
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology; D000818:Animals; D031204:Caloric Restriction; D004261:DNA Replication / Q000502:physiology; D004272:DNA, Mitochondrial / Q000032:analysis*; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats
chemical_list: D004272:DNA, Mitochondrial