Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.
Takeyama
Kazuhide
K
Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259-1143, Japan.
Yoshikawa
Masanobu
M
Oka
Tetsuo
T
Kawaguchi
Mitsuru
M
Suzuki
Toshiyasu
T
Hashimoto
Atsushi
A
D000778:Anesthetics, Dissociative / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D004027:Diencephalon / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D011149:Pons / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D019998:Racemases and Epimerases / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D000099300:Serine Racemase
D000778:Anesthetics, Dissociative; D003605:D-Amino-Acid Oxidase; D007649:Ketamine; D012333:RNA, Messenger; D019998:Racemases and Epimerases; D000099300:Serine Racemase