Homer proteins: implications for neuropsychiatric disorders.
Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.
Szumlinski
Karen K
KK
Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106-9660, USA. szumlinski@psych.ucsb.edu
Kalivas
Peter W
PW
Worley
Paul F
PF
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D018698:Glutamic Acid / Q000378:metabolism*; D000072233:Homer Scaffolding Proteins; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009434:Neural Pathways / Q000378:metabolism* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D009435:Synaptic Transmission / Q000235:genetics
D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D020033:Protein Isoforms; D018698:Glutamic Acid