Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report.
We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.
Valle
Antonio Carlos F do
AC
Department of Infectious Diseases, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. afvalle@ipec.fiocruz.br
Moreira
Luiz Carlos
LC
Almeida-Paes
Rodrigo
R
Moreira
João S
JS
Pizzini
Cláudia V
CV
Muniz
Mauro de Medeiros
Mde M
Zancopé-Oliveira
Rosely M
RM
D000935:Antifungal Agents / Q000627:therapeutic use; D002908:Chronic Disease; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*
D000935:Antifungal Agents; D017964:Itraconazole