title: Improved synthesis of dicyclohexylidene protected quebrachitol and its use in the synthesis of L-chiro-inositol derivatives.
abstract: A modified synthesis of 1L-1,2:3,4-di-O-cyclohexylidene-5-O-methyl-chiro-inositol has been accomplished that improves the overall procedure, yield, and environmental aspects of its formation. Several inositol analogues have been prepared from this intermediate for testing as biosynthetic inhibitors of glycosyl-phosphatidylinositol (GPI) anchor formation.
authors.affiliation: School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Baars
authors.forename: John O
authors.initials: JO
authors.lastname: Hoberg
mesh_terms: D017261:Glycosylphosphatidylinositols / Q000037:antagonists & inhibitors; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D017261:Glycosylphosphatidylinositols; D007294:Inositol; C056476:quebrachitol