title: Diagnostic criteria and treatment of Buerger's disease: a review.
abstract: Buerger's disease is an inflammatory occlusive disorder affecting the small and medium-size arteries and veins of young, predominantly male, smokers. The disorder has been identified as an autoimmune response triggered when nicotine is present. Tobacco abuse is the major contributing risk factor; however, smoking seems to be a synergistic factor rather than the cause of the disease. The traditional diagnosis of Buerger's disease is based on 5 criteria (smoking history, onset before the age of 50 years, infrapopliteal arterial occlusive disease, either upper limb involvement or phlebitis migrans, and absence of atherosclerotic risk factors other than smoking). As there is no specific diagnostic test and an absence of positive serologic markers, confident clinical diagnosis should be made only when all these 5 criteria have been fulfilled although not universally accepted. The angiographic findings in Buerger's disease ("corkscrew," "spider legs," or "tree roots") are helpful but not pathognomonic. A wide spectrum of medical or surgical therapeutic options have been proposed; however, total abstinence from tobacco use remains the only means of stopping the disease progression. The initial management of patients with Buerger's disease should be conservative. Because several arteries may be unaffected, claudicants should be encouraged to walk, whereas patients with "critical" ischemia should be admitted for bed rest in the hospital. Bypass grafting is seldom an option, as the location of the lesions distally leaves little to bypass because of lack of target vessels. A literature review revealed only a few series reporting vascular reconstruction (mainly femorodistal bypasses) in Buerger's disease. Bypass patency rates were suboptimal; however, the corresponding limb salvage rates were satisfactory. A possible explanation is that patent grafts, even over a short period of time, are sufficient to allow healing of ulcers in patients with Buerger's disease.
authors.affiliation: Department of Vascular Surgery, Demokritos University Hospital, Alexandroupolis, Greece. mlazarid@med.duth.gr
authors.forename: M K
authors.initials: MK
authors.lastname: Lazarides
authors.forename: G S
authors.initials: GS
authors.lastname: Georgiadis
authors.forename: T T
authors.initials: TT
authors.lastname: Papas
authors.forename: E S
authors.initials: ES
authors.lastname: Nikolopoulos
mesh_terms: D017668:Age of Onset; D001510:Bed Rest; D018450:Disease Progression; D006801:Humans; D010689:Phlebitis / Q000150:complications; D011150:Popliteal Artery / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013919:Thromboangiitis Obliterans / Q000175:diagnosis* / Q000628:therapy; D014657:Vasculitis / Q000150:complications