Different characters of spleen OX-62 positive dendritic cells between Fischer and Lewis rats.
The phenotype, DNA-binding activities of NF-kappaB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc cells (SDCs) from Fischer rats were compared with those from Lewis rats. Results showed that the expressions of CD11b, MHC-II, CD8, CD45RA, CD54 and CD86 on SDCs were significantly higher in Fischer than those in Lewis rats. The levels of IL-2, IL-4, IL-10 and IFN-gamma in SDCs from Fischer rats were distinctly higher than those from Lewis. Both stimulatory capacity and DNA-binding activities of NF-kappaB in SDCs were all lower in Fischer than those in Lewis rats. These differences may partly contribute to rat strain-specificity in susceptibility to chronic inflammatory stimuli.
Yang
Linsong
L
Immunology and Reproductive Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.
Hou
Yayi
Y
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D004247:DNA / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D004705:Endocytosis; D007249:Inflammation / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism; D010641:Phenotype; D051381:Rats; D011916:Rats, Inbred F344 / Q000276:immunology*; D011917:Rats, Inbred Lew / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D000943:Antigens, Differentiation; D016207:Cytokines; D016328:NF-kappa B; C459465:OX-62 antigen, rat; D004247:DNA