The T-box transcription factor T-bet in immunity and autoimmunity.
The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1 (Th1) immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.
Peng
Stanford L
SL
Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, Palo Alto, CA 94304, USA. stanford.peng@roche.com
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016503:Drug Delivery Systems; D006801:Humans; D007109:Immunity; D020825:T-Box Domain Proteins; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology*; D000098815:T-bet Transcription Factor
D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors