Severe juvenile dermatomyositis: two patients complicated with extra musculocutaneous involvement.
Here we report two patients with severe juvenile dermatomyositis (JDM) complicated with extra musculocutaneous involvement. The first case (a 10-year-old boy) had unusual initial presentation of JDM complicated with interstitial lung disease documented with high-resolution computed tomography. He had a rapidly progressive course and died in 7 weeks after the onset of the disease despite steroid and immunosuppressive treatment. The second case (a 14-year-old boy) was presented with myositis complicated with hepatitis. He also had a chronic course of JDM with unfavorable outcome. It appears that the prognosis of patients with severe JDM is related with the degree of autoimmune vasculitis on extra musculocutaneous involvement.
Tosun
Ayşe
A
Division of Pediatric Neurology, Department of Pediatrics, Ege University Medical School, Bornova, Izmir 35100, Turkey.
Serdaroğlu
Gül
G
Aslan
Mehmet Tayyip
MT
Polat
Muzaffer
M
Akalin
Taner
T
Tekgul
Hasan
H
Gökben
Sarenur
S
D000293:Adolescent; D002648:Child; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis*; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D014657:Vasculitis / Q000209:etiology
D011239:Prednisolone