Diagnosis of lymphoma in the draining lymph node basin at the time of in-transit metastasis of cutaneous melanoma.
The association between cutaneous melanoma and non-Hodgkin's lymphoma (NHL) has been described. Herein we describe two cases in which lymphoma was detected in the draining lymph node basin at the time of the finding of in-transit metastasis of cutaneous melanoma. In both of these cases, sentinel lymph node biopsy at the time of the excision of the primary melanoma showed no evidence of metastatic melanoma or lymphoma. The temporal and spatial correlation of melanoma and NHL in these two cases suggests the possibility of a local failure in immune surveillance.
Arron
Sarah Tuttleton
ST
Department of Dermatology, University of California, San Francisco, California 94143-1706, USA.
Kashani-Sabet
Mohammed
M
D000368:Aged; D006801:Humans; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008545:Melanoma / Q000556:secondary*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000473:pathology*