Feo--transport of ferrous iron into bacteria.
Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the ferrous (Fe2+) form of iron from their environment. Enterobacterial Feo systems are composed of three proteins: FeoA, a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. We provide a review of the current literature combined with a bioinformatic assessment of bacterial Feo systems showing how they exhibit common features, as well as differences in organisation and composition which probably reflect variations in mechanisms employed and function.
Cartron
Michaël L
ML
School of Biological Sciences (AMS Building), University of Reading, Whiteknights, Reading, RG6 6AJ, UK.
Maddocks
Sarah
S
Gillingham
Paul
P
Craven
C Jeremy
CJ
Andrews
Simon C
SC
D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005296:Ferrous Compounds / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D009876:Operon / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D029968:Escherichia coli Proteins; D005296:Ferrous Compounds; D026901:Membrane Transport Proteins; C100775:feo protein, E coli