title: [Model experiment and numerical simulation of marginal pressure in the flow field downstream of the stenostic vessel in vitro].
abstract: For the defects of interpreting the relationship between the distribution and severity of vascular stenostic disease and the low shear stress, the study focus on and explore the rules of the pressure distribution and variation downstream of the stenostic vessel with the numerical simulation and the hydrodynamic model of turbulent flow separation area for in vitro experiment. The results reveal that there is a good compatibility between the model experiment and the numerical simulation; there exists a marked pressure decrease downstream of the stenosis. And the distribution area of low pressure is similar to the characteristic distribution of the stenostic vessel diseases. The study suggested that the numerical simulation can be applied in the study of micro-flow field; the presure distribution and variatioin downstream of the stenostic vessel maybe another factor to trigger the pathogenesis of vessel stenostic diseases.
authors.affiliation: Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. guo-yq@vip.sina.com
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Yingkan
authors.initials: Y
authors.lastname: Shi
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.forename: Weilin
authors.initials: W
authors.lastname: Xue
authors.forename: Shanjun
authors.initials: S
authors.lastname: Liu
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003251:Constriction, Pathologic / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D014652:Vascular Diseases / Q000503:physiopathology*