[Effect of administration of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endo-toxemia, liver function and minimal hepatic encephalopathy in patients with liver cirrhosis].
The purpose of the study was to verify effects of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endotoxin levels, hepatic encephalopathy and liver function in patients with liver cirrhosis. The study involved 39 patients (22 taking Mutaflor and 17 taking placebo). Even though the number combination test showed extended reaction time in patients with described minimal hepatic encephalopathy the drop was not significant in the trend evaluation. However, the treated group displayed significant improvement of intestinal colonisation (p < 0.001) and a trend towards significant reduction of endotoxin levels on day 42 (p = 0.07) and improvement of liver function assessed with the Child-Pugh classification on days 42 and 84 (p = 0.06). Probiotic preparations can therefore represent a significant contribution to this group therapy.
Lata
J
J
Interní gastroenterologická klinika Lékarské fakulty MU a FN Brno, pracoviste Bohunice. jlata@fnbrno.cz
Juránková
J
J
Príbramská
V
V
Fric
P
P
Senkyrík
M
M
Díte
P
P
Kroupa
R
R
D000328:Adult; D000368:Aged; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli; D005260:Female; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000523:psychology*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000150:complications / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000627:therapeutic use*
D004731:Endotoxins