Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response.
Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.
Murray
Peter J
PJ
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA. peter.murray@stjude.org
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003713:Dendritic Cells / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D053701:Receptors, Interleukin-10 / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000378:metabolism; D014122:Toxoplasma / Q000378:metabolism / Q000472:pathogenicity; D014158:Transcription, Genetic; D014616:Vaccinia virus / Q000378:metabolism / Q000472:pathogenicity
D000970:Antineoplastic Agents; D053701:Receptors, Interleukin-10; D050796:STAT3 Transcription Factor; D016753:Interleukin-10