title: Diagnostic performance of MDCT for detecting aortic valve regurgitation.
abstract: OBJECTIVE
  This study evaluates whether ECG-gated 16-MDCT coronary angiography provides a reliable imaging technique for detecting aortic regurgitation (AR).
  
  
  METHODS
  We examined 71 patients prospectively with 16-MDCT angiography using retrospective ECG gating during the mid-to-end diastolic phase. A visible central valvular leakage area was considered as a diagnostic criterion for AR. The central valvular leakage area was quantified in patients with positive transthoracic echocardiography (TTE). We compared 16-MDCT to Doppler TTE, the accepted diagnostic standard based on semiquantitative regurgitation jet analysis (grade 0-3+ for mild, moderate, and severe).
  
  
  RESULTS
  The overall sensitivity of 16-MDCT for the identification of patients with AR was 81%. The specificity was 91%, the negative predictive value was 70%, and the positive predictive value was 95%. Of the 71 patients, 48 had AR determined by TTE, and 16-MDCT correctly detected AR in 39 of those 48 patients. The sensitivity of 16-MDCT for the detection of patients with moderate and severe AR (grade > or = 1.5+) was 95%, and the specificity was 96% (20 of 21 patients). The sensitivity of 16-MDCT for identification of patients with mild AR (grade < or = 1+) was 70%, and the specificity was 92% (19 of 27 patients). Quantification of the central valvular leakage area was not possible in 50% of cases with AR by TTE because of valve calcifications.
  
  
  CONCLUSIONS
  Sixteen-MDCT coronary angiography provides an accurate, noninvasive imaging technique to detect moderate and severe aortic regurgitation (grade > or = 1.5+). However, severe valve calcifications and mild AR limit its results.
authors.affiliation: Clinical Department of Radiology II, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria. Gudrun.Feuchtner@uibk.ac.at
authors.forename: Gudrun M
authors.initials: GM
authors.lastname: Feuchtner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dichtl
authors.forename: Thomas
authors.initials: T
authors.lastname: Schachner
authors.forename: Silvana
authors.initials: S
authors.lastname: Müller
authors.forename: Ammar
authors.initials: A
authors.lastname: Mallouhi
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Friedrich
authors.forename: Dieter Zur
authors.initials: DZ
authors.lastname: Nedden
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D015203:Reproducibility of Results