Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus.
Gastrointestinal (GI) sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do severe and life-threatening problems occur. The pathogenesis of abnormal upper GI sensory-motor function in diabetes is incompletely understood and is most likely multi-factorial of origin. Diabetic autonomic neuropathy as well as acute suboptimal control of diabetes has been shown to impair GI motor and sensory function. Morphological and biomechanical remodeling of the GI wall develops during the duration of diabetes, and may contribute to motor and sensory dysfunction. In this review sensory and motility disorders of the upper GI tract in diabetes is discussed; and the morphological changes and biomechanical remodeling related to the sensory-motor dysfunction is also addressed.
Zhao
Jingbo
J
Center of Excellence in Visceral Biomechanics and Pain, the Research Building room 404, Aalborg Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. aas.jzhao@nja.dk
Frøkjaer
Jens Brøndum
JB
Drewes
Asbjørn Mohr
AM
Ejskjaer
Niels
N
D001341:Autonomic Nervous System / Q000503:physiopathology; D001696:Biomechanical Phenomena; D048909:Diabetes Complications / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000473:pathology / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D041742:Upper Gastrointestinal Tract / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology*