Mitochondrial genome anatomy and species-specific lifespan.
Several lines of evidence implicate mtDNA in the mechanisms of aging and longevity. The authors examined possible links between mtDNA composition and maximum lifespan of multicellular eukaryotes, including 102 mammals. MLS correlates positively with cytosine and negatively with adenine or thymine content, whereas guanine has no apparent effect. This is especially noted for primates. It appears that an increase in MLS of mammals is associated with thymine-to-cytosine substitution. The results suggest that the MLS may be associated with stability and/or mutability of mtDNA and call for further investigation of the mitochondrial genome as a potential target for lifespan-extending interventions.
Lehmann
Gilad
G
Department of Microbiology and Immunology, Center for Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Budovsky
Arie
A
Muradian
Khachik K
KK
Fraifeld
Vadim E
VE
D000375:Aging / Q000502:physiology*; D000818:Animals; D003596:Cytosine; D004272:DNA, Mitochondrial / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D008136:Longevity / Q000502:physiology; D013045:Species Specificity; D013941:Thymine
D004272:DNA, Mitochondrial; D003596:Cytosine; D013941:Thymine