title: Recurrent catheter-related bloodstream infections: Risk factors and outcome.
abstract: OBJECTIVE
  To identify risk factors for recurrent catheter related bloodstream infections (CR-BSIs). The study was undertaken at the University of Utah Hospital and involved patients who had a CR-BSI followed by catheter removal and reinsertion between January 1998 and February 2002.
  
  
  METHODS
  A retrospective chart review for the cohort study of catheters initially infected, which were then followed to study risk factors for a subsequent infection. Both central line and peripherally inserted central line catheters were included in the study. A recurrent CR-BSI was defined as positive blood cultures after three negative cultures, coupled with positive catheter tip culture or no other evident new source of infection.
  
  
  RESULTS
  Twenty-five (34%) of 73 patients had a recurrent CR-BSI. The first CR-BSI occurred a mean of 20.4 days after catheter insertion whereas recurrence developed a mean of 12.1 days after reinsertion (p = 0.392). Coagulase-negative staphylococci (60%) were the most common cause of recurrent infection. The recurrence was more common among the patients who were given blood product transfusion (hazard ratio (HR) 2.3; confidence interval (CI) 1.02-5.67, p = 0.049). In 20 (27%) patients, catheters were changed over a guidewire. The guidewire catheter exchange was not found to be associated with an increased risk of recurrent infection (p = 0.582).
  
  
  CONCLUSIONS
  Catheter replacement to a new site, instead of rewiring, was not shown to decrease the risk for recurrent infection. The transfusion of blood products was associated with an increased risk for recurrent infection.
authors.affiliation: Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah, School of Medicine, Salt Lake City, Utah, USA. aerbay@kangurum.net
authors.forename: Ayşe
authors.initials: A
authors.lastname: Erbay
authors.forename: Onder
authors.initials: O
authors.lastname: Ergönül
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Stoddard
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Samore
mesh_terms: D000328:Adult; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling / Q000382:microbiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000209:etiology / Q000382:microbiology; D013210:Staphylococcus / Q000302:isolation & purification; D065227:Transfusion Reaction