title: [Harmonisation of validation strategies and estimation of the associated uncertainty in the framework of assay laboratoires accreditation].
abstract: In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an analytical procedure is described: the accuracy profile based on the estimation of the total error of the measurements. This profile build with beta-expectation tolerance intervals can also compute with efficiency the uncertainty related to the results of a laboratory, which is an essential parameter for the accreditation of laboratories under ISO 17025.
authors.affiliation: Laboratoire de Chimie Analytique, Institut de Pharmacie, Université de Liege, Avenue de l'Hôpital, 1 Bat. B36, 4000 Liège, Belgique. Ph.Hubert@ulg.ac.be
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: E
authors.initials: E
authors.lastname: Rozet
authors.forename: B
authors.initials: B
authors.lastname: Boulanger
authors.forename: W
authors.initials: W
authors.lastname: Dewé
authors.forename: M
authors.initials: M
authors.lastname: Laurentie
authors.forename: N
authors.initials: N
authors.lastname: Dubois
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: M
authors.initials: M
authors.lastname: Feinberg
mesh_terms: D000068:Accreditation; D007753:Laboratories / Q000592:standards*; D012015:Reference Standards; D035501:Uncertainty