Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis.
We have recently shown that loss-of-function mutations in the filaggrin gene, carried by about 10% of people of European ethnicity, cause ichthyosis vulgaris and are strong predisposing factors for atopic dermatitis and asthma secondary to atopic dermatitis. These results demonstrate a prominent role for the epidermal barrier in atopic disease and have important implications for the study of complex traits.
Irvine
Alan D
AD
Department of Paediatric Dermatology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland.
McLean
W H Irwin
WH
D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000378:metabolism; D000091344:Filaggrin Proteins; D005796:Genes / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis / Q000172:deficiency* / Q000235:genetics*; D009154:Mutation; D012867:Skin / Q000737:chemistry / Q000378:metabolism*
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins