title: Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo.
abstract: A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k(ex) = 3.1 x 10(7) s(-1)) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.forename: Ying-Xia
authors.initials: YX
authors.lastname: Li
authors.forename: Ga-Lai
authors.initials: GL
authors.lastname: Law
authors.forename: Kwan
authors.initials: K
authors.lastname: Man
authors.forename: Wing-Tak
authors.initials: WT
authors.lastname: Wong
authors.forename: Hao
authors.initials: H
authors.lastname: Lei
mesh_terms: D000818:Animals; D001372:Aza Compounds / Q000737:chemistry*; D002412:Cations / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D000080027:Cyclams; D005682:Gadolinium / Q000737:chemistry* / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D002412:Cations; D000080027:Cyclams; D006571:Heterocyclic Compounds; D014867:Water; C038072:cyclen; D005682:Gadolinium