title: Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.
abstract: The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. We sequenced the Plasmodium falciparum cytochrome b gene of 135 African isolates. Our data showed a high mutation rate (8.9%); however, the risk of emergence spreading of atovaquone-resistant P. falciparum strains could be limited.
authors.affiliation: Department of Parasitology, Rangueil University Hospital, 31059 Toulouse 9, France. berry.a@chu-toulouse.fr
authors.forename: A
authors.initials: A
authors.lastname: Berry
authors.forename: A
authors.initials: A
authors.lastname: Senescau
authors.forename: J
authors.initials: J
authors.lastname: Lelièvre
authors.forename: F
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: R
authors.initials: R
authors.lastname: Fabre
authors.forename: B
authors.initials: B
authors.lastname: Marchou
authors.forename: J F
authors.initials: JF
authors.lastname: Magnaval
mesh_terms: D000349:Africa; D000595:Amino Acid Sequence; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D053626:Atovaquone / Q000627:therapeutic use*; D045303:Cytochromes b / Q000235:genetics*; D004351:Drug Resistance; D004641:Emigration and Immigration; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D000962:Antimalarials; D045303:Cytochromes b; D053626:Atovaquone