A concomitant review of the effects of diabetes mellitus and hypothyroidism in wound healing.
This paper reviews the negative impact of diabetes mellitus or hypothyroidism on wound healing, both in experimental and clinical settings. Since both are metabolic disorders of great clinical importance, special attention is given, not only to their pathophysiology, but also to their biochemical and histological effects on tissue integrity and regeneration. Also, special focus is awarded on wound healing of the gastrointestinal tract, i.e. in intestinal anastomosis, and how these disorders can lead to wound dehiscence. Since diabetes mellitus and hypothyroidism can coexist in clinical settings, more research must be directed on their influence on wound healing, considering them as one clinical entity.
Ekmektzoglou
Konstantinos A
KA
Laboratory of Experimental Surgery and Surgical Research, N.S. Christeas, Athens School of Medicine, Athens, Greece. ekmektzo@hotmail.com
Zografos
Georgios C
GC
D001786:Blood Glucose / Q000502:physiology; D003094:Collagen; D048909:Diabetes Complications / Q000473:pathology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D006133:Growth Substances / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000503:physiopathology; D013537:Sutures; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology / Q000503:physiopathology
D001786:Blood Glucose; D006133:Growth Substances; D003094:Collagen