Active methylene phosphinic peptides: a new diversification approach.
[reaction: see text] Simple, rapid, and efficient methods for P(1)' diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.
Matziari
Magdalini
M
University of Athens, Department of Chemistry, Laboratory of Organic Chemistry, Panepistimiopolis Zografou, Athens, Greece.
Nasopoulou
Magdalini
M
Yiotakis
Athanasios
A
D000478:Alkylation; D020650:Combinatorial Chemistry Techniques; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008697:Methane / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010721:Phosphinic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry
D010455:Peptides; D010721:Phosphinic Acids; D008666:Metalloendopeptidases; D015032:Zinc; D008697:Methane