Successful treatment of life-threatening bleeding after cesarean section with recombinant activated factor VII.
Hemorrhagic shock developed in a 29-year-old nullipara without coagulopathy after emergency caesarean section. Treatment with uterotonic drugs, prostaglandins, and conservative procedures with transfusion of packed red cells and fresh-frozen plasma failed to control the diffuse vaginal and uterine bleeding. Finally an intravenous bolus injection of 90 microg/kg recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Bagsvaerd, Denmark), was given and showed success within 20 minutes after administration, without any side effects.
Heilmann
L
L
Department of Obstetrics and Gynecology, City Hospital Rüsselsheim, Germany. dr_lothar_heilmann@yahoo.de
Wild
C
C
Hojnacki
B
B
Pollow
K
K
D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects*; D016638:Critical Illness; D005167:Factor VII / Q000627:therapeutic use*; D015942:Factor VIIa; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000628:therapy; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa