Subretinal fibrosis and uveitis syndrome associated with ulcerative colitis.
OBJECTIVE
We report a case of subretinal fibrosis and panuveitis syndrome as an extraintestinal manifestation of ulcerative colitis.


METHODS
We present an interventional case report of a 40-year-old female patient with inactive ulcerative colitis referred to our center for refractory uveitis in her right eye.


RESULTS
She was diagnosed with subretinal fibrosis and uveitis syndrome after work-up ruled out tuberculosis, bartonellosis, Lyme disease, and sarcoidosis. Right eye multifocal choroiditis and panuveitis syndrome with subretinal fibrosis was diagnosed, and posterior pole subretinal fibrosis caused a 90% loss of visual efficiency. She had concurrent dermatological manifestations but no gastrointestinal symptoms. One year of immunosuppressive therapy with methotrexate (7.5 mg/week) controlled ocular inflammation. Two colitis episodes, with no visual involvement, were recorded during follow-up. Her final, right-eye, best-corrected visual acuity remained stable at 0.160 due to scarring sequela after 7 years of follow-up.


CONCLUSIONS
Subretinal fibrosis and uveitis syndrome can occur as a sight-threatening extraintestinal manifestation of ulcerative colitis.
Fuentes-Páez
Graciana
G
Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), Facultad de Medicina, University of Valladolid, Calle Ramón y Cajal 7, Valladolid, 47005, Spain.
Martínez-Osorio
Hernán
H
Herreras
José M
JM
Calonge
Margarita
M
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D005355:Fibrosis; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D012164:Retinal Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014605:Uveitis / Q000188:drug therapy / Q000209:etiology*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents