title: Shaken not stirred: a facile synthesis of 1,4-bis(furo[2,3-d]-pyrimidine-2,4(1H,3H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N,N'-dimethylbarbituric acid, and terephthaldialdehyde.
abstract: A simple and efficient synthesis of 1,4-bis(furo[2,3-d]pyrimidine-2,4(1H,3H)-dione-5-yl)benzene derivatives was achieved via a one-pot three-component reaction of isocyanides, N,N'-dimethylbarbituric acid, and terephthaldialdehyde in DMF at room temperature for 30 min. These improved reaction conditions allow the preparation of highly substituted furopyrimidinones in high yields and purity under mild reaction conditions.
authors.affiliation: Petrochemical Department, Iran Polymer and Petrochemical Institute, PO Box 14965-115, Tehran, Iran. m.teimouri@ippi.ac.ir
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Teimouri
authors.forename: Reihaneh
authors.initials: R
authors.lastname: Bazhrang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001463:Barbiturates / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis; D003486:Cyanides / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010795:Phthalic Acids / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000447:Aldehydes; D001463:Barbiturates; D001555:Benzene Derivatives; D003486:Cyanides; D005663:Furans; D010795:Phthalic Acids; D011744:Pyrimidinones; C011363:terephthalic acid; C032232:barbituric acid