title: [Synthesis of thiophene and alpha-terthiophene derivatives with antiproliferative activity].
abstract: We have synthesised a series of known alpha-terthiophene lead molecules with PKC (protein kinase C) inhibitory activity and the compounds were tested in cell proliferation assay on EGF-RTK (epidermal growth factor receptor protein tyrosine kinase) over-expressing tumour cell line (A431). We found that two of them had excellent antiproliferative activity. We prepared a focused molecule library around the thiophene and the terthiophene scaffold and examined these compounds in cell proliferation assay on A431.
authors.affiliation: Semmelweis Egyetem, Kooperációs Kutató Központ, Budapest.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Székelyhidi
authors.forename: János
authors.initials: J
authors.lastname: Pató
authors.forename: Bálint
authors.initials: B
authors.lastname: Hegymegi-Barakonyi
authors.forename: Péter
authors.initials: P
authors.lastname: Bánhegyi
authors.forename: György
authors.initials: G
authors.lastname: Mészáros
authors.forename: György
authors.initials: G
authors.lastname: Kéri
authors.forename: Lászlo
authors.initials: L
authors.lastname: Orfi
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D013876:Thiophenes; C019101:alpha-terthienyl; D066246:ErbB Receptors; D011493:Protein Kinase C