Effects of milk enriched with omega-3 fatty acid, oleic acid and folic acid in patients with metabolic syndrome.
OBJECTIVE
Patients with metabolic syndrome (MS) have increased cardiovascular risk factors. Dietary modifications mainly polyunsatturated fatty acids intake, can improve them. The present study was performed to assess the effects of enriched milk with omega-3 and oleic fatty acids, folic acid and vitamin E, in these patients.


METHODS
We performed a randomized, placebo-controlled and open clinical trial, among 72 patients with MS for 3 months. Thirty-six of them consumed 500 cm(3) per day of semi-skimmed milk (control group), and the others consumed 500 cm(3) per day of enriched milk (test group). Daily supplements in this group were 5.7 g of oleic acid, 0.2g of omega-3 fatty acid, 150 microg of folic acid and 7.5mg of vitamin E. Serum for total and HDL cholesterol, triglycerol, Apo B, glucose, insulin, hs-CRP, homocysteine and fatty acids contents in serum phospholipids, was obtained at the beginning and at the end of the study. LDL cholesterol was calculated by Friedewald formula.


RESULTS
Four patients in the test group, and two in the control group dropped out. In the test group a decrease in serum total cholesterol (-6.2%, P=0.006), LDL cholesterol (-7.5%, P=0.032), triglycerol (-13.3%, P=0.016), Apo B (-5.7%, P=0.036), glucose (-5.3%, P=0.013), and homocysteine (-9.5%, P=0.00) was observed. Any of these parameters changed in the control group.


CONCLUSIONS
Dietary supplementation with 500 cm(3) of enriched milk with omega-3 fatty acid, oleic acid and folic acid, reduces serum tryglicerides, total and LDL cholesterol, Apo B, glucose and homocysteine in patients with MS. This milk is well tolerated and accepted by the patients.
Benito
Pedro
P
Department of Endocrinology, Reina Sofía Hospital, Córdoba University, Spain. benlop@telefonica.net
Caballero
Javier
J
Moreno
Jesus
J
Gutiérrez-Alcántara
Carmen
C
Muñoz
Carmen
C
Rojo
Gemma
G
Garcia
Sara
S
Soriguer
Federico C
FC
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001055:Apolipoproteins B / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D005527:Food, Fortified; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy; D008875:Middle Aged; D008892:Milk / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D001055:Apolipoproteins B; D001786:Blood Glucose; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D007328:Insulin; D010743:Phospholipids; D014280:Triglycerides; D006710:Homocysteine; D014810:Vitamin E; D002097:C-Reactive Protein; D005492:Folic Acid; D002784:Cholesterol