[Nephrogenic diabetes insipidus induced by colchicine--a case report].
In some cases diabetes insipidus may be induced by taking medications. In this article we report the case of a 58-year-old man with manifest polyuria induced by colchicine administered because of a gout attack. Interestingly, similar symptoms were observed 6 years earlier after treatment with gentamycin. In the described state of the examined patient early detection of the disease, colchicine withdrawal and temporary amiloride (and indometacin) administration led to a full normalisation of the patient's clinical status. A similar reaction to two different drugs responsible for only a small percentage of iatrogenic diabetes insipidus suggests that some patients may exhibit a general "hypersensitivity" to the development of a drug-induced vasopressin resistance and that patients with the history of iatrogenic diabetes insipidus should not be treated or should be treated cautiously with other drugs known to induce vasopressin-resistant polyuria.
Krysiak
Robert
R
Katedra Farmakologii, Zakład Farmakologii Klinicznej Slaskiej Akademii Medycznej, Katowice. r.krysiak@pharmanet.com.pl
Okopień
Bogusław
B
Haberka
Maciej
M
Herman
Zbigniew Stanisław
ZS
D000584:Amiloride / Q000627:therapeutic use*; D003078:Colchicine / Q000009:adverse effects* / Q000627:therapeutic use; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000188:drug therapy*; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011141:Polyuria
D000584:Amiloride; D003078:Colchicine