title: A simple homemade reaction station for use in parallel solution-phase synthesis. Optimization of a regioselective one-step deprotective o-formylation reaction mediated by the Vilsmeier-Haack reagent POCl3.DMF.
abstract: We report herein the fabrication of a simple and price-affordable portable reaction station for use in parallel solution-phase synthesis. This homemade device uses currently available laboratory components and equipment. Specifically designed to fit standard magnetic hotplates/stirrers, it can simultaneously hold up to 24 heated and magnetically stirred glass reactors of both 10 and 50 mL capacities. Glass reactors are connected by flexible 16-gauge metal needles to a central gas manifold equipped with an inlet/outlet for vacuum and inert gases. Reaction temperatures can be optimally varied from -78 ( composite function)C to 150 degrees C. Using a statistical screening DOE method, this parallel array reactor station has been successfully operated to optimize the one-step deprotective O-formylation of a sterically hindered bis-O-tert-butyldiphenylsilyl (O-TBDPS) aromatic diol. The latter transformation was mediated by the Vilsmeier-Haack reagent POCl3.DMF using a range of Lewis acid and metal salt promoters, including their binary combinations.
authors.affiliation: Department of Chemistry, Bar-Ilan University, Ramat-Gan, 52900, Israel.
authors.forename: Vadim
authors.initials: V
authors.lastname: Kotlyar
authors.forename: Lior
authors.initials: L
authors.lastname: Shahar
authors.forename: J-P
authors.initials: JP
authors.lastname: Lellouche
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation*; D004987:Ethers / Q000737:chemistry*; D005561:Formates / Q000138:chemical synthesis*; D007202:Indicators and Reagents / Q000737:chemistry; D008956:Models, Chemical
chemical_list: D004987:Ethers; D005561:Formates; D007202:Indicators and Reagents