title: Antifungal combination treatment: a future perspective.
abstract: The use of antifungal combination therapy is a new clinical approach for combating fungal infections. Although few conclusive clinical studies have been performed to date, data exist that strongly suggest that combination therapy would benefit specific patient subgroups (e.g. stem-cell transplant recipients). This paper examines the evidence available from in vitro, experimental, and clinical studies, and seeks to discover viable clinical strategies for this promising new therapeutic approach.
authors.affiliation: Département d'Hématologie et d'Oncologie, Hôpital de Hautepierre, Strasbourg, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Fohrer
authors.forename: Luc
authors.initials: L
authors.lastname: Fornecker
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Nivoix
authors.forename: Corina
authors.initials: C
authors.lastname: Cornila
authors.forename: Cristina
authors.initials: C
authors.lastname: Marinescu
authors.forename: Raoul
authors.initials: R
authors.lastname: Herbrecht
mesh_terms: D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy; D000077336:Caspofungin; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005544:Forecasting; D006801:Humans; D066298:In Vitro Techniques; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000009:adverse effects / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin