Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus.
The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
Shelat
Phullara B
PB
Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri-Columbia, 65212, USA.
Coulibaly
Aminata P
AP
Wang
Qun
Q
Sun
Albert Y
AY
Sun
Grace Y
GY
Simonyi
Agnes
A
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D020710:RGS Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*
D020710:RGS Proteins; D012333:RNA, Messenger