General aspects of immunotoxicology including validation issues.
Histologic examination of lymphoid organs has revealed immunotoxic effects of a broad range of substances. The thymus has proven especially sensitive. The relative lack of sensitivity of mucosa-associated lymphoid cells and tissues may be due to shortcomings in the way they are examined. Validation of ways to examine mucosal lymphoid tissues and cells and development of histopathological tools to flag a compound as a potential inducer of autoimmune disease or allergy are challenges for the future.
Frieke Kuper
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TNO Quality of Life, Department of Toxicology and Applied Pharmacology, P.O. Box 360, 3700 AJ Zeist, The Netherlands. kuper@voeding.tno.nl
D000818:Animals; D007107:Immune System / Q000187:drug effects* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000633:toxicity*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D015203:Reproducibility of Results; D018675:Toxicity Tests / Q000379:methods*; D015262:Xenobiotics / Q000633:toxicity*
D007166:Immunosuppressive Agents; D015262:Xenobiotics