title: Angiogenesis: from plants to blood vessels.
abstract: Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.
authors.affiliation: Angiogenesis and Traditional Chinese Medicine Laboratory, Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK. tpf1000@cam.ac.uk
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Fan
authors.forename: Ju-Ching
authors.initials: JC
authors.lastname: Yeh
authors.forename: Kar Wah
authors.initials: KW
authors.lastname: Leung
authors.forename: Patrick Y K
authors.initials: PY
authors.lastname: Yue
authors.forename: Ricky N S
authors.initials: RN
authors.lastname: Wong
mesh_terms: D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D027561:Salvia miltiorrhiza / Q000737:chemistry; D032841:Sinomenium / Q000737:chemistry; D013025:Glycine max; D029757:Tripterygium / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts