Procarbazine for non-Hodgkin's lymphoma.
Procarbazine hydrochloride is an oral alkylating agent with activity against lymphoma. It is most commonly used in the treatment of Hodgkin's disease. The use of procarbazine-containing chemotherapeutic regimens in non-Hodgkin's lymphoma fell out of favor with the advent of CHOP. We report two patients with relapsed and/or refractory follicular lymphoma that achieved a complete and durable remission with a prolonged course of daily procarbazine.
Chaar
Bassem T
BT
Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63110, USA. chaarbt@slu.edu
Salem
Pascale
P
Petruska
Paul J
PJ
D000328:Adult; D000477:Alkylating Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011344:Procarbazine / Q000627:therapeutic use*; D012074:Remission Induction; D033581:Stem Cell Transplantation / Q000379:methods
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D008996:Monoamine Oxidase Inhibitors; D011344:Procarbazine