The effect of bariatric surgery on adipocytokines, renal parameters and other cardiovascular risk factors in severe and very severe obesity: 1-year follow-up.
OBJECTIVE
To evaluate the effect of weight loss after bariatric surgery (BS) on peripheral adipocytokines, renal parameters and other cardiovascular risk factors (CVRFs).


METHODS
A total of 70 (41 women) extremely obese adults were prospectively studied before and 12 months after surgery.


METHODS
24 (15 women) normal-weight adults. Anthropometric, biochemical and renal parameters were recorded.


RESULTS
Presurgery, adiponectin (ADPN) was lower, whereas leptin, insulin resistance, C-reactive protein, creatinine clearance and albuminuria were higher in patients than controls (P<0.001). All parameters improved postsurgery. Changes in ADPN correlated negatively with leptin, insulin resistance, albumin, C-reactive protein, and creatinine clearance. Multiple regression analysis: using changes in ADPN as the dependent variable, only changes in insulin resistance (P=0.005) and albumin (P=0.019) were significant independent determinants for changes in ADPN. No statistical differences were found in relation to the degree of obesity.


CONCLUSIONS
Patients changed to obesity type I after surgery. This implies a substantial improvement of CVRFs including ADPN, creatinine clearance and albuminuria. Changes in plasma ADPN correlated negatively with insulin resistance and with albuminemia but not with renal parameters. The lack of differences between different degrees of obesity suggests that the relationship between weight and CVRFs no longer exists when obesity becomes very extreme.
Serra
A
A
Department of Nephrology, Hospital Universitari "Germans Trias i Pujol", Carretera del Canyet s/n, 08916 Badalona (Barcelona), Spain.
Granada
M L
ML
Romero
R
R
Bayés
B
B
Cantón
A
A
Bonet
J
J
Rull
M
M
Alastrue
A
A
Formiguera
X
X
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000419:Albuminuria; D050110:Bariatric Surgery; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007668:Kidney / Q000503:physiopathology*; D020738:Leptin / Q000097:blood; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis; D015431:Weight Loss
D052242:Adiponectin; D020738:Leptin; D012709:Serum Albumin; D002097:C-Reactive Protein; D003404:Creatinine