Regulatory T cells and toll-like receptors in cancer therapy.
T regulatory (Treg) cells that suppress immune responses may limit the efficiency of cancer immunotherapy. Recent findings indicate that Toll-like receptors (TLR) directly regulate the suppressive activity of Treg cells. Linking TLR signaling to the functional control of Treg cells may offer new opportunities to improve the outcome of cancer immunotherapy by coadminstration of certain TLR ligands.
Wang
Rong-Fu
RF
The 2nd Hospital, Zhejiang University Medical School, Hangzhou, China. Rongfuw@bcm.tmc.edu
D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D051193:Toll-Like Receptors