title: Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin.
abstract: The neutral mononuclear copper(II) complex with the quinolone antibacterial drug sparfloxacin has been prepared and characterized with IR, UV-vis, and EPR spectroscopies and X-ray crystallography. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms.
authors.affiliation: Institute of Physical Chemistry, NCSR Demokritos, 15310 Aghia Paraskevi Attikis, Greece.
authors.forename: Eleni K
authors.initials: EK
authors.lastname: Efthimiadou
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Sanakis
authors.forename: Catherine P
authors.initials: CP
authors.lastname: Raptopoulou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Karaliota
authors.forename: Nikos
authors.initials: N
authors.lastname: Katsaros
authors.forename: George
authors.initials: G
authors.lastname: Psomas
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000032:analysis / Q000378:metabolism; D024841:Fluoroquinolones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013053:Spectrophotometry
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009942:Organometallic Compounds; D015363:Quinolones; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C061363:sparfloxacin