[Dissolution study of the gentin tablets].
To establish individual dissolution test for the tablets gentin, which have a marked influence on the secretory function of the stomach (increase the free acidity of the gastric juice and stimulate enzymoproduction function of the stomach), and gastroprotective functioning, the conditions for the test realization were studied and specified, using apparatus "Rotating Basket" (Dissolution test, apparatus 1, p.1791, USP XXIII, 1995). For the quantification of the active ingredients in buffer solutions chromatospectrophotometric method was used. The same conditions were used for the accomplishment of the dissolution test using apparatus "Rotating Paddle" (Dissolution test, apparatus 2, p.1791, USP XXIII, 1995). Metrologic characteristics were compared for the evaluation of the reproducibility of the results. Obtained data showed better reproducibility of the results for the apparatus "Rotating Paddle" compare to the apparatus "Rotating Basket". Estimated conditions are useful for the routine control of the tablets "Gentin" in the case of manufacturing.
Tsagareishvili
N T
NT
Bakuridze
A D
AD
Kurdiani
N G
NG
Murtazashvili
T Zh
TZh
D002021:Buffers; D006801:Humans; D028321:Plant Preparations / Q000737:chemistry*; D011753:Pyrones / Q000032:analysis*; D012995:Solubility; D013607:Tablets
D002021:Buffers; D028321:Plant Preparations; D011753:Pyrones; D013607:Tablets