title: New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.
abstract: Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece.
authors.forename: George N
authors.initials: GN
authors.lastname: Ziakas
authors.forename: Eleni A
authors.initials: EA
authors.lastname: Rekka
authors.forename: Antonios M
authors.initials: AM
authors.lastname: Gavalas
authors.forename: Phaedra T
authors.initials: PT
authors.lastname: Eleftheriou
authors.forename: Panos N
authors.initials: PN
authors.lastname: Kourounakis
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D051545:Cyclooxygenase 1 / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D016859:Lipoxygenase Inhibitors / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D051381:Rats; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D010636:Phenols; D002084:Butylated Hydroxytoluene; C035407:2,6-di-tert-butylphenol; D002351:Carrageenan; D051545:Cyclooxygenase 1; C496513:Ptgs1 protein, rat