title: Dramatic remission of treatment-resistant depression after the cessation of tricyclic antidepressants.
abstract: Recently, tricyclic antidepressants (TCAs) have been used mainly for treatment-resistant depression (TRD) because of their significant side effects . We report a patient whose prolonged depressive symptoms dramatically improved after the cessation of TCAs. TCAs may cause deterioration of depressive symptoms due to their neurotoxicity.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Sugawara
authors.forename: H
authors.initials: H
authors.lastname: Higuchi
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects*; D000077465:Cabergoline; D003865:Major Depressive Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000008:administration & dosage; D005260:Female; D016666:Fluvoxamine / Q000008:administration & dosage; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D004873:Ergolines; D000077465:Cabergoline; D016666:Fluvoxamine; D007099:Imipramine