title: Behaviour of MG-63 osteoblast-like cells on wood-based biomorphic SiC ceramics coated with bioactive glass.
abstract: The aim of this study was to test the in vitro cytotoxicity of wood-based biomorphic Silicon Carbide (SiC) ceramics coated with bioactive glass, using MG-63 human osteoblast-like cells, with a view to their application in bone implantology. To better understand the scope of this study, it should be taken into account that biomorphic SiC ceramics have only recently been developed and this innovative product has important properties such as interconnected porosity, high strength and toughness, and easy shaping. In the solvent extraction test, all the extracts had almost no effect on cellular activity even at 100% concentration, and cells incubated in the bioactive glass-coated SiC ceramics extracts showed a proliferation rate similar to that of the Thermanox control. There were no significant differences when the cellular attachment response of the cells on the wood-based biomorphic SiC ceramics, uncoated or coated with bioactive glass, was compared to the one exhibited by reference materials like Ti6Al4V and bulk bioactive glass. This fact looks very promising for biomedical applications.
authors.affiliation: Dpto. Bioquímica, Genética e Inmunología, University of Vigo, 36200, Vigo, Spain.
authors.forename: A
authors.initials: A
authors.lastname: de Carlos
authors.forename: J P
authors.initials: JP
authors.lastname: Borrajo
authors.forename: J
authors.initials: J
authors.lastname: Serra
authors.forename: P
authors.initials: P
authors.lastname: González
authors.forename: B
authors.initials: B
authors.lastname: León
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D017554:Carbon Compounds, Inorganic / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D005898:Glass; D006801:Humans; D007700:Kinetics; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D017655:Silicon Compounds / Q000737:chemistry* / Q000494:pharmacology; D014934:Wood
chemical_list: D018786:Bone Substitutes; D017554:Carbon Compounds, Inorganic; D020099:Coated Materials, Biocompatible; D017655:Silicon Compounds; C023506:Glass ceramics; C022088:silicon carbide