Evaluation of the interaction of surfactants with stratum corneum model membrane from Bothrops jararaca by DSC.
The interaction of surfactants sodium dodecyl sulfate (SDS), cetyl trimethyl ammonium chloride (CTAC) and lauryl alcohol ethoxylated (12 mol ethylene oxide) (LAE-12OE) was evaluated on the stratum corneum (SC) of shed snake skins from Bothrops jararaca, used as model membrane, and thermal characterized by differential scanning calorimetry (DSC). Surfactant solutions were employed above of the critical micellar concentration (CMC) with treatment time of 8h. The SDS interaction with the SC model membrane has increased the characteristic transition temperature of 130 degrees C in approximately 10 degrees C for the water loss and keratin denaturation, indicating an augmentation of the water content. Samples treated with CTAC have a decrease of the water loss temperature, while, for the LAE-12OE treated samples, changes on the transition temperature have not been observed.
Baby
André Rolim
AR
Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, 580 Prof. Lineu Prestes Av., bloco 13, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil. andrerb@usp.br
Lacerda
Aurea Cristina Lemos
AC
Velasco
Maria Valéria Robles
MV
Lopes
Patrícia Santos
PS
Kawano
Yoshio
Y
Kaneko
Telma Mary
TM
D000818:Animals; D017837:Bothrops; D002152:Calorimetry, Differential Scanning; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D007851:Dodecanol / Q000737:chemistry; D004817:Epidermis / Q000737:chemistry*; D066298:In Vitro Techniques; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*
D002593:Cetrimonium Compounds; D013501:Surface-Active Agents; D007851:Dodecanol; D012967:Sodium Dodecyl Sulfate; D000077286:Cetrimonium