trans-Platinum reporting for duty.
HIV infects millions of people worldwide; however, no cures for this AIDS-causing retrovirus exist. A new approach using trans-platinum-nucleobase complexes to inhibit viral replication by disrupting the nucleocapsid protein-RNA interaction is presented in this issue of Chemistry & Biology.
Burdette
Shawn
S
Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA.
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D008958:Models, Molecular; D017671:Platinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D015032:Zinc / Q000737:chemistry
D019380:Anti-HIV Agents; D017671:Platinum Compounds; D015032:Zinc