Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition.
Cocaine treatment trials suffer from a high rate of attrition. We examined pretreatment neurophysiological factors to identify participants at greatest risk. Twenty-five participants were divided into concordant and discordant groups following electroencephalogram (EEG) measures recorded prior to a double-blind, placebo-controlled treatment trial. Three possible outcomes were examined: successful completion, dropout, and removal. Concordant (high perfusion correlate) participants had an 85% rate of successful completion, while discordant participants had a 15% rate of successful completion. Twenty-five percent of dropouts and 50% of participants removed were discordant (low perfusion correlate), while only 25% of those who completed were discordant. Failure to complete the trial was not explained by depression, craving, benzoylecgonine levels or quantitative electroencephalogram (QEEG) power; thus cordance may help identify attrition risk.
Venneman
Sandy
S
Medication Development Unit, Research Service, and Psychiatry Service, West Los Angeles VA Medical Center, California, USA. VennemanS@uhv.edu
Leuchter
Andrew
A
Bartzokis
George
G
Beckson
Mace
M
Simon
Sara L
SL
Schaefer
Melodie
M
Rawson
Richard
R
Newton
Tom
T
Cook
Ian A
IA
Uijtdehaage
Sebastian
S
Ling
Walter
W
D000328:Adult; D000465:Algorithms; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage; D018696:Neuroprotective Agents / Q000008:administration & dosage; D010352:Patient Dropouts / Q000523:psychology / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography; D018570:Risk Assessment; D012642:Selegiline / Q000008:administration & dosage; D012815:Signal Processing, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon
D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D012642:Selegiline