title: Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients with aortic valve stenosis.
abstract: OBJECTIVE
  To evaluate multislice computed tomography (MSCT) as an alternative to coronary angiography, we prospectively studied its diagnostic accuracy for the detection of significant coronary artery lesions in patients with significant aortic valve stenosis undergoing valve surgery.
  
  
  BACKGROUND
  In patients with aortic valve stenosis, coronary angiography is still recommended before surgery. Multislice computed tomography is a promising noninvasive technique for the detection of significant coronary artery lesions.
  
  
  METHODS
  Fifty-five consecutive patients scheduled for coronary angiography in the preoperative assessment of aortic valve stenosis underwent 16-slice MSCT 24 h before coronary angiography. We analyzed coronary lesions, image quality, and arterial calcium score.
  
  
  RESULTS
  The sensitivity of the MSCT-based strategy in detecting significant stenosis was 100%, and its specificity 80%. The positive and negative predictive values were respectively 55% and 100%. For calcium scores <1,000 (77% of patients), MSCT detected all patients without coronary artery disease, enabling conventional coronary angiography to be avoided in 35 of 55 cases (80%). For calcium scores >1,000, MSCT enabled conventional coronary angiography to be avoided in only 6% of cases, either because significant stenosis was found with a possible indication of revascularization, or because the examination was not interpretable.
  
  
  CONCLUSIONS
  The results of this initial experience in relatively few patients suggest that MSCT-based coronary angiography may serve as an alternative to invasive coronary angiography to rule out significant coronary artery disease in patients scheduled for elective aortic valve replacement. Larger studies are necessary to fully explore the potential of coronary MSCT to improve preoperative risk stratification.
authors.affiliation: Department of Cardiology, Brest University Hospital, Brest, France. martine.gilard@chu-brest.fr
authors.forename: Martine
authors.initials: M
authors.lastname: Gilard
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cornily
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Pennec
authors.forename: Cedric
authors.initials: C
authors.lastname: Joret
authors.forename: Grégoire
authors.initials: G
authors.lastname: Le Gal
authors.forename: Jacques
authors.initials: J
authors.lastname: Mansourati
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Blanc
authors.forename: Jacques
authors.initials: J
authors.lastname: Boschat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods