Autophagy by ARF: a short story.
In this issue of Molecular Cell, Reef et al. (2006) describe a shortened unstable form of the ARF tumor suppressor protein that localizes within mitochondria, where it reduces membrane potential and triggers autophagy. Could this account for the Mdm2- and p53-independent tumor suppressive effects of ARF?
Sherr
Charles J
CJ
Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016158:Genes, p53; D006801:Humans; D008564:Membrane Potentials; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism; D025803:Tumor Suppressor Protein p14ARF / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
C417743:Cdkn2a protein, mouse; D019941:Cyclin-Dependent Kinase Inhibitor p16; D025803:Tumor Suppressor Protein p14ARF; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2