Excretion of urinary enzymes in normal pregnancy.
OBJECTIVE
To study the pattern of excretion of enzymes in urine during normal pregnancy.


METHODS
Primigravidae, with uncomplicated pregnancies, were followed up throughout gestation. Urine samples were collected from them and activities of alanine aminopeptidase (AAP), gamma-glutamyl transferase (GGT), acid phosphatase (ACP) and N-acetyl-beta-d-glucosaminidase (NAG) activities in urine were estimated.


RESULTS
Small but significant increases were found in the activities of AAP and NAG excreted through the course of pregnancy. The changes seen in excretion of ACP and GGT were not statistically significant.


CONCLUSIONS
Changes in excretion of ACP and GGT may be useful indicators of renal dysfunction in pregnancy, as their activities did not vary significantly through the course of normal pregnancy.
Jacob
Molly
M
Department of Biochemistry, Christian Medical College, Vellore 632002, India. jacob@cmcvellore.ac.in
Balasubramaniam
Neelakantan
N
D000118:Acetylglucosaminidase / Q000652:urine; D000135:Acid Phosphatase / Q000652:urine; D018826:CD13 Antigens / Q000652:urine; D004798:Enzymes / Q000652:urine*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000652:urine*; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000652:urine
D004798:Enzymes; D005723:gamma-Glutamyltransferase; D000135:Acid Phosphatase; D000118:Acetylglucosaminidase; D018826:CD13 Antigens