[Study on preparation of beta-cyclodextrin inclusion compound for borneolumsyntheticum from Huoxuezhitong capsules].
OBJECTIVE
To study the optimum inclusion process of clolloid mill for borneolumsyntheticum from Huoxuezhitong Capsules.


METHODS
The study was carried out with orthogonal design. The borneol content in inclusion complex, the utilization ratio of borneol, and synthesis grading were used as evaluating indicator to review the effects of 3 factors, including the proportion of borneolumsyntheticum to beta-cyclodextrin (mol: mol), milling time and water addition.


RESULTS
The optimum process were borneolumsyntheticum: beta-cyclodextrin was 1:1, the milling time was 40 min, water addition was double.


CONCLUSIONS
The optimum process is feasible, and fit for industrial production, with the advantage of high utilization ratio, shot time and low energy consumption.
Guan
Zhi-Yu
ZY
Nanjing ZhongShan Pharmaceutical Factory Technology Center, Nanjing 210012, China.
Pu
Cun-Hai
CH
Zhao
Kai-Jun
KJ
D001682:Biological Availability; D001892:Camphanes / Q000032:analysis*; D002214:Capsules; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004337:Drug Carriers; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D009822:Oils, Volatile / Q000032:analysis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014867:Water / Q000008:administration & dosage; D047392:beta-Cyclodextrins
D001892:Camphanes; D002214:Capsules; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; D014867:Water