title: Multiple cutaneous and uterine leiomyomas associated with gastric GIST.
abstract: BACKGROUND
  There are a number of reports documenting familial cases of leiomyomatosis cutis associated with uterine leiomyomata. However, to our knowledge, the association of gastrointestinal stromal tumour (GIST) with this entity has not as yet been reported. We report an interesting case of cutaneous leiomyomatosis, metachronous uterine leiomyomata, and a gastric GIST in a 43-year-old woman.
  
  
  METHODS
  The patient had previously undergone two separate uterine myomectomies at ages 25 and 26 years, respectively, followed by a hysterectomy at 27 years. At 36 years she underwent partial gastrectomy for excision of GIST and this was followed by the development of extensive, symptomatic cutaneous leiomyomata at 43 years. In the report, we have documented histological, immunohistochemical and clinical observations and furthermore report on the therapeutic measures undertaken.
  
  
  CONCLUSIONS
  We report an interesting association of cutaneous leiomyomatosis, uterine leiomyomas and GIST.
authors.affiliation: Department of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, General Campus, Ottawa, ON, Canada.
authors.forename: Manisha
authors.initials: M
authors.lastname: Lamba
authors.forename: Shailendra
authors.initials: S
authors.lastname: Verma
authors.forename: Robert
authors.initials: R
authors.lastname: Prokopetz
authors.forename: Tadeusz A
authors.initials: TA
authors.lastname: Pierscianowski
authors.forename: Maha
authors.initials: M
authors.lastname: Jabi
authors.forename: Terence
authors.initials: T
authors.lastname: Moyana
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077235:Vinorelbine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine; D008727:Methotrexate