[Functional state of the dopaminergic system of the brain on a background of different doses of amitriptiline].
The aim of the work is study of adsorbtion dynamics of amitriptiline on the surface of erythrocytes and to compare the obtained data with the character of pharmacokinetics and pharmacodynamics of amitriptiline in plasma. With the method of PLC the adsorb gas was been analyzed. The drag was administered to adult drugs and the blood sampled were collected following 10, 20, 60 min. and 4,0; 6,0 and 8,0 hours after the injection. In the supernatants from the erythrocytes and in the blood plasma the dopaminergic systems has been analyzed. Our data proved the ability of amitriptiline to adsorb on the surface of erythrocytes. Its concentration in the supernatant washed from the surface of erythrocytes and in the blood were not the same. It may be connected with the character and quantity of functional groups located on the surface of erythrocytes.
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D000639:Amitriptyline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline