Bilateral osteonecrosis of the head of the femur during treatment with retinoic acid in a young patient with acute promyelocytic leukemia.
All-trans retinoic acid (ATRA) is the drug of choice for the treatment of acute promyelocytic leukemia (APL). In general, ATRA is well tolerated, but it does have side effects, the most severe of which is ATRA syndrome. We report the case of a young patient with APL treated with ATRA for induction and maintenance therapy who then developed avascular necrosis of both femoral heads. We also review cases of APL patients with osteonecrosis of the femoral head after ATRA therapy.
Sakakura
Miho
M
Division of Hematology and Oncology, Mie University School of Medicine, Mie, Japan.
Nishii
Kazuhiro
K
Usui
Eiji
E
Monma
Fumihiko
F
Tsukada
Tetsuya
T
Shiku
Hiroshi
H
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D011859:Radiography; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D000970:Antineoplastic Agents; D014212:Tretinoin