title: Angiokeratoma corporis diffusum in a patient with no recognizable enzyme abnormalities.
abstract: BACKGROUND
  Angiokeratoma corporis diffusum is a clinical variant of angiokeratoma that is typically associated with an enzyme deficiency in the metabolism of glycoprotein, most notably Fabry disease, resulting in many other systemic manifestations.
  
  
  METHODS
  We report a case of angiokeratoma corporis diffusum that did not have an identifiable enzyme deficiency. A review of the literature revealed few similar cases.
  
  
  CONCLUSIONS
  Angiokeratoma corporis diffusum without recognizable enzyme deficiencies appears to be a distinct clinical entity with a benign course.
authors.affiliation: Department of Dermatology, University of Texas Medical Branch at Galveston, USA. bckelly@utmb.edu
authors.forename: Brent
authors.initials: B
authors.lastname: Kelly
authors.forename: Erica
authors.initials: E
authors.lastname: Kelly
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D000795:Fabry Disease / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D006119:Groin; D006801:Humans; D008297:Male