The therapeutic potential of Angiotensin-(1-7) as a novel Renin-Angiotensin System mediator.
In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2-Angiotensin-(1-7)-Mas axis.
Simões e Silva
Ana Cristina
AC
Departamento de Pediatria, Faculdade de Medicina-UFMG, Av. Alfredo Balena, 190, Belo Horizonte, MG, 30130-100, Brazil. acssilva@hotmail.com
Pinheiro
Sérgio Veloso Brant
SV
Pereira
Regina Maria
RM
Ferreira
Anderson José
AJ
Santos
Robson Augusto Souza
RA
D000803:Angiotensin I / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D005837:Genitalia, Male / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects*
D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7)