Domino reactions with fluorinated five-membered heterocycles. alpha-Trifluoromethyl alpha-amino acids with unsaturated side-chains.
Alpha-trifluoromethyl alpha-amino acids with unsaturated side-chains have been prepared from 5-fluoro-4-trifluoromethyloxazole and allyl, propargyl as well as terpene alcohols in a one-pot procedure.
Burger
K
K
Department of Organic Chemistry, University of Leipzig, Leipzig, Germany. burger@organik.chemie.uni-leipzig.de
Hennig
L
L
Tsouker
P
P
Spengler
J
J
Albericio
F
F
Koksch
B
B
D000438:Alcohols / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry
C526577:5-fluoro-4-(trifluoromethyl)-2-phenyloxazole; D000438:Alcohols; D000596:Amino Acids; D006571:Heterocyclic Compounds; D010080:Oxazoles