The impact of genomics on the analysis of host resistance to infectious disease.
The advent of new technologies and resources, including the complete sequence of mammalian genomes, has had a dramatic impact on the genetic analysis of susceptibility to infections in humans and in animal models of infection. Genes responsible for simple or complex control of susceptibility to infection with different pathogens have been recently identified and characterized, and are reviewed herein.
Tuite
Ashleigh
A
Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 907, Montreal, QC H3G 1Y6, Canada.
Gros
Philippe
P
D000818:Animals; D003141:Communicable Diseases / Q000235:genetics* / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D016952:Legionella pneumophila / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology; D016788:Plasmodium chabaudi / Q000276:immunology