title: Determination of paracetamol: historical evolution.
abstract: Paracetamol is a common analgesic and antipyretic drug that is used for the relief of fever, headaches and other minor aches and pains. Their determination in pharmaceuticals is of paramount importance, since an overdose of paracetamol can cause fulminating hepatic necrosis and other toxic effects. Many analytical methodologies have been proposed for the determination of paracetamol. The aim of the present study is to evaluate the utility of different techniques for quantification of paracetamol content in pharmaceutical formulations and biological samples.
authors.affiliation: Department of Analytical Chemistry, Faculty of Sciences, University of Málaga, Campus Teatinos, 29071 Málaga, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Espinosa Bosch
authors.forename: A J
authors.initials: AJ
authors.lastname: Ruiz Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Sánchez Rojas
authors.forename: C
authors.initials: C
authors.lastname: Bosch Ojeda
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D017022:Flow Injection Analysis; D006801:Humans; D008163:Luminescent Measurements; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared
chemical_list: D000082:Acetaminophen