Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis.
Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis. Pharamcokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance. These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications. As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.
Akins
Ronda L
RL
Department of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, 79106, USA. ronda.akins@ttuhsc.edu
Haase
Mark R
MR
Levy
Eric N
EN
D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016638:Critical Illness; D017576:Daptomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000378:metabolism*; D016984:Enterococcus faecium; D017809:Fatal Outcome; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008297:Male; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D017576:Daptomycin