title: Luminescent pyrimidine hydrazide oligomers with peptide affinity.
abstract: The modular synthesis of pyrimidine oligohydrazides and their peptide binding ability are reported. Ethylene glycol substituents ensure water solubility of the compounds. The pattern of hydrogen bond donors and hydrogen bond acceptors resembles the functionalities of a peptide backbone, and intramolecular hydrogen bonds restrict conformational mobility. The pyrimidine heterocycles show emission at 423 nm if either excited with light of 320 nm or by a FRET process from a nearby Trp residue. This property is useful for the luminescent detection of interactions with peptides and proteins.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg, Germany.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Li
authors.forename: Stefan
authors.initials: S
authors.lastname: Miltschitzky
authors.forename: Burkhard
authors.initials: B
authors.lastname: König
mesh_terms: D008164:Luminescent Proteins / Q000737:chemistry* / Q000494:pharmacology*; D008956:Models, Chemical; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D008164:Luminescent Proteins; D010455:Peptides; D011743:Pyrimidines