Physiological and metabolic implications of V-ATPase isoforms in the kidney.
Not all vacuolar-type H(+)-ATPases (V-ATPases) are alike; those responsible for H(+) movement across plasma membranes contain some different, tissue-specific subunit isoforms. This brief review outlines those that have special relevance to the kidney, and illustrates their importance by describing various human diseases where loss of local proton pump function not only confers a severe phenotype, but has revealed related tissues where these same isoforms are expressed, signifying their physiological importance.
Karet
Fiona E
FE
Division of Renal Medicine and Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Box 139, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK. fek1000@cam.ac.uk
D000141:Acidosis, Renal Tubular; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D020033:Protein Isoforms; D021122:Protein Subunits; D014018:Tissue Distribution; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D020033:Protein Isoforms; D021122:Protein Subunits; D025262:Vacuolar Proton-Translocating ATPases