title: Myeloablative allogeneic stem cell transplantation for advanced stage multiple myeloma: very long-term follow up of a single center experience.
abstract: We aimed to review the long-term outcome of myeloablative allogeneic stem cell transplantation (SCT) performed for multiple myeloma (MM) at our institution. Records of all patients who received standard myeloablative allogeneic SCT for MM were retrospectively reviewed. Overall survival (OS), progression-free survival (PFS), and event-free survival (EFS) were calculated using the Kaplan-Meier method. In total 37 transplants had been performed. Median follow up post-SCT was 108 months (range: 33-148). The majority of patients suffered advanced stage disease and/or had received multiple prior therapies prior to SCT. Transplant-related mortality (TRM) at 100 days was 32%. Grades 2-4 acute graft-vs.-host disease (GVHD) occurred in 18 patients (49%), and extensive stage chronic GVHD in seven (28%) of 25 patients surviving greater than day 100. Median OS, PFS, and EFS were 28 months, 66 months and 13 months, respectively, with 5 year OS, PFS, and EFS 40%, 54% and 24%. Our results suggest that allogeneic SCT, even when performed in advanced stage, heavily pretreated MM, still results in long-term EFS in a significant minority of patients. Efforts should continue on alternative allogeneic SCT approaches to reduce the high early TRM rate associated with myeloablative conditioning.
authors.affiliation: Division of Oncology, Royal Brisbane and Women's Hospital, Queensland, Australia. glen_kennedy@health.qld.gov.au
authors.forename: G A
authors.initials: GA
authors.lastname: Kennedy
authors.forename: J
authors.initials: J
authors.lastname: Butler
authors.forename: J
authors.initials: J
authors.lastname: Morton
authors.forename: G
authors.initials: G
authors.lastname: Hill
authors.forename: R
authors.initials: R
authors.lastname: Western
authors.forename: J
authors.initials: J
authors.lastname: Cummings
authors.forename: R
authors.initials: R
authors.lastname: Allison
authors.forename: S
authors.initials: S
authors.lastname: Durrant
mesh_terms: D000328:Adult; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D033581:Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D019653:Myeloablative Agonists