Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores.
Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of approximately 450 microm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.
Bae
Chang-Jun
CJ
School of Materials Science and Engineering, Seoul National University, Seoul 151-742, Korea. kimhe@snu.ac.kr
Kim
Hae-Won
HW
Koh
Young-Hag
YH
Kim
Hyoun-Ee
HE
D000469:Alkaline Phosphatase / Q000032:analysis / Q000378:metabolism; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001842:Bone and Bones / Q000737:chemistry; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019245:Compressive Strength; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008422:Materials Testing; D010006:Osteoblasts / Q000187:drug effects / Q000201:enzymology / Q000502:physiology / Q000648:ultrastructure; D012516:Osteosarcoma / Q000473:pathology; D016062:Porosity; D013997:Time Factors
D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite; D000469:Alkaline Phosphatase