title: Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder.
abstract: An inability to self-regulate negative emotions appears to play a pivotal role in the genesis of major depressive disorder. This inability may be related to a dysfunction of the neural circuitry underlying emotional self-regulation. This functional magnetic resonance imaging study was conducted to test this hypothesis. Depressed individuals and controls were scanned while they attempted to voluntarily down-regulate sad feelings. The degree of difficulty experienced during down-regulation of sadness was higher in depressed individuals. Furthermore, there was greater activation in the right dorsal anterior cingulate cortex, right anterior temporal pole, right amygdala, and right insula in depressed individuals. These results suggest that emotional dysregulation in major depressive disorder is related to a disturbance in the neural circuitry of emotional self-regulation.
authors.affiliation: Département de Psychologie, Université de Montréal, Montréal, Québec, Canada. mario.beauregard@umontreal.ca
authors.forename: Mario
authors.initials: M
authors.lastname: Beauregard
authors.forename: Vincent
authors.initials: V
authors.lastname: Paquette
authors.forename: Johanne
authors.initials: J
authors.lastname: Lévesque
mesh_terms: D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology*; D015536:Down-Regulation / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D008032:Limbic System / Q000033:anatomy & histology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000033:anatomy & histology / Q000503:physiopathology*; D011237:Predictive Value of Tests