title: Ancestry of beagles in lifespan studies of radionuclide toxicity at the University of Utah.
abstract: Analysis of the ancestry of the 1,262 lifespan beagles (LSB) entered into lifespan studies at the Radiobiology Division, University of Utah, beginning in 1952 and ending in 1980, indicated that about 97% of ancestor citations in the various pedigrees were of only 10 breeding animals (breeders) among breeders within the beagle colony. In turn, just 18 AKC-registered "champion" beagles from outside of this colony (founders) accounted for about 98% of all ancestor citations among founders for the LSB. We conclude from this study that the animals used in the lifespan radionuclide experiments can be considered to be somewhat genetically interrelated.
authors.affiliation: Department of Radiology, Radiobiology Division, University of Utah, 729 Arapeen Drive #2334, Salt Lake City, UT 84108-1218, USA. ray.lloyd@hsc.utah.edu
authors.forename: R D
authors.initials: RD
authors.lastname: Lloyd
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
authors.forename: S C
authors.initials: SC
authors.lastname: Miller
authors.forename: F W
authors.initials: FW
authors.lastname: Bruenger
authors.forename: W S S
authors.initials: WS
authors.lastname: Jee
mesh_terms: D000818:Animals; D004285:Dogs / Q000145:classification* / Q000235:genetics*; D008136:Longevity / Q000528:radiation effects*; D010375:Pedigree; D011868:Radioisotopes / Q000633:toxicity*; D013045:Species Specificity; D018675:Toxicity Tests / Q000379:methods* / Q000662:veterinary*; D014495:Universities; D014589:Utah
chemical_list: D011868:Radioisotopes