title: Gastroesophageal reflux in healthy subjects induced by two different species of chilli (Capsicum annum).
abstract: BACKGROUND
  Although the ingestion of chilli has been associated with gastroesophageal reflux (GER) symptoms, there are no studies that have explored the effect of a chronic ingestion of different kinds of chilli with a variable content of capsaicin as a cause of GER.
  
  
  METHODS
  The effect of chilli on esophageal 24-hour pH monitoring was studied in 12 healthy subjects without GER symptoms before and after of ingestion one of two kinds of chilli. Patients were randomized to ingest 3 g daily of cascabel chilli (Capsicum annum coraciforme containing 880 ppm of capsaicin) or ancho chilli (Capsicum annum grossum containing 488 ppm of capsaicin).
  
  
  RESULTS
  After chilli ingestion, the Johnson De Meester Index (JDI) increased significantly [basal: 7 (1-14), after chilli: 13 (2-69), p = 0.0047]. When considering both kinds of chilli separately, the JDI varied, although nonsignificantly, with the ancho chilli [basal: 3 (1-8), after chilli: 10 (2-69), p = 0.11], and significantly with the cascabel chilli [basal: 10 (5-14), after chilli: 18 (2-44), p = 0.028].
  
  
  CONCLUSIONS
  Our results suggest that the chronic ingestion of chilli induces GER, and that the magnitude of the induced reflux seems to be related to the kind of chilli.
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
authors.forename: Pilar
authors.initials: P
authors.lastname: Milke
authors.forename: Angelica
authors.initials: A
authors.lastname: Diaz
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Valdovinos
authors.forename: Segundo
authors.initials: S
authors.lastname: Moran
mesh_terms: D000328:Adult; D002212:Capsicum / Q000009:adverse effects*; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011312:Pressure; D012016:Reference Values; D012307:Risk Factors; D017365:Spices / Q000009:adverse effects*