title: [Optimization of formulation of Fufang Danshen immediate release tablet by colligation score].
abstract: OBJECTIVE
  To optimize the formulation of immediate release tablet.
  
  
  METHODS
  The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.
  
  
  RESULTS
  The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.
  
  
  CONCLUSIONS
  It is successful to prepare on immediate release tablet using the optimized formula above.
authors.affiliation: Institute of Pharmaceutics, China Pharmaceutical University, Nanjing. rongfenghu2003@hotmail.com
authors.forename: Rong-feng
authors.initials: RF
authors.lastname: Hu
authors.forename: Jia-bi
authors.initials: JB
authors.lastname: Zhu
authors.forename: Dai-yin
authors.initials: DY
authors.lastname: Peng
authors.forename: Ji-hui
authors.initials: JH
authors.lastname: Tang
authors.forename: An
authors.initials: A
authors.lastname: Zhou
mesh_terms: D002482:Cellulose; D003912:Dextrins; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013607:Tablets
chemical_list: D003912:Dextrins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D002482:Cellulose