Microprocessor controlled transdermal drug delivery.
Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.
Subramony
J Anand
JA
ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94043, USA. asubramo@alzus.jnj.com
Sharma
Ashutosh
A
Phipps
J B
JB
D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007478:Iontophoresis; D008012:Lidocaine / Q000008:administration & dosage; D008838:Microcomputers
D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine; D005283:Fentanyl