title: Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.
abstract: An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.
authors.affiliation: Laboratory of Pediatric Onco-Hematology, Department of Pediatrics, University Hospital of Padua, Padua, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Germano
authors.forename: Martina
authors.initials: M
authors.lastname: Pigazzi
authors.forename: Laura
authors.initials: L
authors.lastname: del Giudice
authors.forename: Marta
authors.initials: M
authors.lastname: Campo Dell'Orto
authors.forename: Monica
authors.initials: M
authors.lastname: Spinelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Zangrando
authors.forename: Paolo
authors.initials: P
authors.lastname: Paolucci
authors.forename: Saverio
authors.initials: S
authors.lastname: Ladogana
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Basso
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D019070:Cell Lineage; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics / Q000648:ultrastructure; D002999:Clone Cells / Q000473:pathology; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D015321:Gene Rearrangement; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D011495:Histone-Lysine N-Methyltransferase; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008954:Models, Biological; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D014178:Translocation, Genetic; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D018398:Homeodomain Proteins; C497422:KMT2A protein, human; C113855:MLL-AF4 fusion protein, human; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C097899:homeobox protein HOXA9; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3