[Clinical significance of anti-phosphatidylserine-prothrombin complex antibodies in antiphospholipid syndrome].
We clarified the clinical significance of IgG anti-phosphatidylserine-prothrombin complex (PS-PT) antibodies in the antiphospholipid syndrome (APS). The study population consisted of 122 patients with SLE and lupus-like disease. IgG anti-PS-PT antibodies were detected in 44% of 59 patients according to the diagnostic criteria by Harris and Hughes. This frequency was significantly (p < 0.005) higher than the 14% seen in patients without APS. IgG anti-PS-PT antibodies were strongly (p < 0.005) associated with thrombosis. In addition, IgG anti-PS-PT antibodies were positive in 64% of IgG beta2-GPI dependent anti-cardiolipin antibody negative APS patients under the Sapporo criteria. The above findings indicate that IgG anti-PS-PT antibodies as well as beta2,-GPI dependent anti-cardiolipin antibodies should be examined in the diagnosis of APS.
Kaburaki
Junichi
J
Department of Internal Medicine, Tokyo Electric Power Company Hospital.
Kuwana
Masataka
M
Kameda
Hideto
H
Takeuchi
Tsutomu
T
Okada
Jun
J
Katayama
Masao
M
Yoshida
Shunji
S
Ikeda
Yasuo
Y
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D010718:Phosphatidylserines / Q000276:immunology*; D011516:Prothrombin / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D010718:Phosphatidylserines; D011516:Prothrombin