title: Enhancing the utility of prostascint SPECT scans for patient management.
abstract: This project investigated reducing the artifact content of In-ill ProstaScint SPECT scans for use in treatment planning and management. Forty-one patients who had undergone CT or MRI scans and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans were included. SPECT volume sets, reconstructed using Ordered Set-Expectation Maximum (OS-EM) were compared against those reconstructed with standard Filtered Back projection (FBP). Bladder activity in Tc-99m scans was suppressed within an ellipsoidal volume. Tc-99m voxel values were subtracted from the corresponding In-111 after scaling based on peak activity within the descending aorta. The SPECT volume data sets were merged with the CT or MRI scans before and after processing. Volume merging, based both on visual assessment and statistical evaluation, was not affected. Thus iterative reconstruction together with bladder suppression and blood pool subtraction may improve the interpretation and utility of ProstaScint SPECT scans for patient management.
authors.affiliation: Department of Radiology, NYU School of Medicine, New York, USA. noz@nucmed.med.nyu.edu
authors.forename: Marilyn E
authors.initials: ME
authors.lastname: Noz
authors.forename: Grace
authors.initials: G
authors.lastname: Chung
authors.forename: Benjamin Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Gerald Q
authors.initials: GQ
authors.lastname: Maguire
authors.forename: J Keith
authors.initials: JK
authors.lastname: DeWyngaert
authors.forename: Jay V
authors.initials: JV
authors.lastname: Doshi
authors.forename: Elissa L
authors.initials: EL
authors.lastname: Kramer
authors.forename: Antoinette D
authors.initials: AD
authors.lastname: Murphy-Walcott
authors.forename: Michael P
authors.initials: MP
authors.lastname: Zeleznik
authors.forename: Noeun G
authors.initials: NG
authors.lastname: Kwak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D005791:Patient Care; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011859:Radiography; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data*