title: Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum.
abstract: Rats with excitotoxic lesions of the dorsal or ventral hippocampus and control rats were trained on 2 spatial working memory tasks: the standard version of the radial maze with 8 baited arms and the non-matching-to-place procedure in the T maze. Dorsal lesions produced deficits in both tasks, whereas ventral lesions did not affect learning in either of them. A volumetric analysis of subicular damage showed that dorsal hippocampal lesions caused a deficit in the non-matching-to-place only when accompanied by damage to the dorsal subiculum; on the other hand, lesions to the dorsal hippocampus impaired performance in the radial-arm maze regardless of the extent of subicular damage.
authors.affiliation: Ecole de Psychologie, Université Laval, Québec, PQ, Canada.
authors.forename: Olivier
authors.initials: O
authors.lastname: Potvin
authors.forename: Kevin
authors.initials: K
authors.lastname: Allen
authors.forename: Geneviève
authors.initials: G
authors.lastname: Thibaudeau
authors.forename: François Y
authors.initials: FY
authors.lastname: Doré
authors.forename: Sonia
authors.initials: S
authors.lastname: Goulet
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001930:Brain Injuries / Q000139:chemically induced / Q000503:physiopathology*; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D016202:N-Methylaspartate / Q000633:toxicity; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate