title: CTX-M-15-producing multidrug-resistant enteroaggregative Escherichia coli in the United Arab Emirates.
abstract: Extended-spectrum beta-lactamase (ESBL) production was demonstrated in five independent, multidrug-resistant isolates of enteroaggregative Escherichia coli (EAEC) from the United Arab Emirates, representing 11.3% of the EAEC isolates recovered during 1 year. All five isolates carried the bla(CTX-M-15) and the bla(TEM-1) genes, the former positioned 48 bp downstream of an ISecp1 element. In two isolates, the bla(CTX-M-15 )and bla(TEM-1) genes were located on a 95-kb plasmid. This is the first detailed description and characterisation of ESBL production in enteroaggregative E. coli and also the first report of CTX-M-producing organisms encountered on the Arabian Peninsula.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
authors.forename: A
authors.initials: A
authors.lastname: Sonnevend
authors.forename: K
authors.initials: K
authors.lastname: Al Dhaheri
authors.forename: T
authors.initials: T
authors.lastname: Mag
authors.forename: M
authors.initials: M
authors.lastname: Herpay
authors.forename: J
authors.initials: J
authors.lastname: Kolodziejek
authors.forename: N
authors.initials: N
authors.lastname: Nowotny
authors.forename: A
authors.initials: A
authors.lastname: Usmani
authors.forename: F A
authors.initials: FA
authors.lastname: Sheikh
authors.forename: T
authors.initials: T
authors.lastname: Pál
mesh_terms: D000328:Adult; D002675:Child, Preschool; D017931:DNA Primers / Q000737:chemistry; D004269:DNA, Bacterial / Q000737:chemistry; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D014479:United Arab Emirates; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D017931:DNA Primers; D004269:DNA, Bacterial; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1