title: KO(t)Bu-promoted three-component coupling of aldehydes and alkynes: highly efficient synthesis of 1-en-4-yn-3-ols and 2-en-4-yn-1-ols.
abstract: A KO(t)Bu-promoted three-component coupling reaction of aldehydes and alkynes without a transition-metal catalyst was developed in which the sequential addition/isomerization/addition processes take place in one pot. This reaction could be developed into a straightforward and effective method for rapid access to stereodefined (E)-1-en-4-yn-3-ol and (Z)-2-en-4-yn-1-ol compounds.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Hu
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Ai-Xia
authors.initials: AX
authors.lastname: Wang