title: Glucocorticoid therapy ameliorated hypoglycemia in insulin-like growth factor-II-producing solitary fibrous tumor.
abstract: A 54-year-old man with a past history of multi-operation for solitary fibrous tumor was hospitalized for hypoglycemia. Computed tomography demonstrated multiple tumors in the liver but not in the pancreas. His serum insulin-like growth factor (IGF)-II level was normal, but immunoblot analysis and immunohistochemistry revealed a high molecular weight form of IGF-II in the serum and tumor. Surgical resection was impossible, because of tumor dissemination. Hypoglycemia was repeated despite infusion of glucose and glucagon. Glucocorticoid dramatically and continuously abolished hypoglycemia. In cases of inoperable IGF-II-producing tumor, glucocorticoid therapy may be promising for hypoglycemia.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Tsuro
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kojima
authors.forename: Shingo
authors.initials: S
authors.lastname: Okamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshiji
authors.forename: Masao
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Masahito
authors.initials: M
authors.lastname: Uemura
authors.forename: Masahide
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Saihou
authors.initials: S
authors.lastname: Kou
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukui
mesh_terms: D005350:Fibroma / Q000150:complications / Q000378:metabolism*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D007335:Insulin-Like Growth Factor II; D011239:Prednisolone