title: Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease.
abstract: OBJECTIVE
  Impaired cerebrovascular reactivity (CVR) to vasodilating agents is a predictor of the onset and prognosis of ischemic stroke. It is realized that the CVR improves or worsens when measured periodically during the clinical course in medically treated patients with occlusive cerebrovascular disease. In these patients, we investigated the possible relationship between the interval change in CVR and that in systemic blood pressure (BP).
  
  
  METHODS
  Forty-two patients (14 females and 28 males, mean age +/- SD: 65.3 +/- 8.8 years) with severe stenosis or occlusion of the common carotid, internal carotid, or middle cerebral arteries repeatedly underwent single photon emission computed tomography (SPECT) studies using 123I-iodoamphetamine to measure cerebral blood flow (CBF) distribution and CVR at a more-than-6-month interval (mean +/- SD: 18.5 +/- 8.8 months). The CVR was separately estimated in cerebral hemispheres ipsilateral and contralateral to the most severe vascular lesion as the % increase in CBF after acetazolamide loading to CBF at rest. Systemic BP was measured four times at enrollment and the follow-up SPECT studies during resting and acetazolamide loading. Average BP at each SPECT study was an average of BP measurements during resting and acetazolamide loading. Interval changes in CVR were correlated with those in average systolic BP, average diastolic BP, and average mean arterial BP.
  
  
  RESULTS
  The interval changes in CVR were significantly correlated with those in average diastolic BP in the ipsilateral hemisphere (y = 0.71x + 1.43, r2 = 0.11, p < 0.05) and in the contralateral hemisphere (y = 0.88x - 0.46, r2 = 0.16, p < 0.05) but not with those in average systolic BP or average mean arterial BP.
  
  
  CONCLUSIONS
  In medically treated patients with steno-occlusive carotid artery or middle cerebral artery lesions, the interval change in CVR to acetazolamide by means of 123I-IMP SPECT was influenced by the diastolic BP at the SPECT studies. Monitoring diastolic BP is important to evaluate interval change in CVR.
authors.affiliation: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, D9, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kimura
authors.forename: Naohiko
authors.initials: N
authors.lastname: Oku
authors.forename: Katsufumi
authors.initials: K
authors.lastname: Kajimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Katoh
authors.forename: Makiko Rai
authors.initials: MR
authors.lastname: Tanaka
authors.forename: Masashi
authors.initials: M
authors.lastname: Takasawa
authors.forename: Masao
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Jun
authors.initials: J
authors.lastname: Hatazawa
mesh_terms: D000086:Acetazolamide; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging* / Q000628:therapy; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000187:drug effects; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000628:therapy; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine; D000086:Acetazolamide