title: [The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line].
abstract: OBJECTIVE
  To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.
  
  
  METHODS
  Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.
  
  
  RESULTS
  Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).
  
  
  CONCLUSIONS
  Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.
authors.affiliation: Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Lin
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Zhou
authors.forename: Sheng-Fu
authors.initials: SF
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.forename: Qian-Ming
authors.initials: QM
authors.lastname: Chen
mesh_terms: D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005347:Fibroblasts; D006801:Humans; D009062:Mouth Neoplasms; D014062:Tongue Neoplasms