title: A new variant of Brucella melitensis.
abstract: Brucella melitensis is highly pathogenic and constitutes a serious risk to public health. In Argentina, biovar 1 has been isolated from infected animals, but the Rev.1 strain vaccine is not authorised for use. This report describes nine atypical B. melitensis isolates obtained from humans. These isolates grew slowly, produced small colonies and were susceptible to penicillin and dyes, similar to the B. melitensis Rev.1 vaccine strain, but were inhibited by streptomycin 2.5 mg/L. The isolation of such atypical B. melitensis variants has never been reported from animals in Argentina, and could indicate the emergence of a new mutant variant.
authors.affiliation: Brucellosis Laboratory, Administración Nacional de Laboratorios e Institutos de Salud Dr C.G. Malbrán, ANLIS, Buenos Aires, Argentina. nidia@elsitio.net
authors.forename: N E
authors.initials: NE
authors.lastname: Lucero
authors.forename: S M
authors.initials: SM
authors.lastname: Ayala
authors.forename: G I
authors.initials: GI
authors.lastname: Escobar
authors.forename: M
authors.initials: M
authors.lastname: Grayon
authors.forename: I
authors.initials: I
authors.lastname: Jacques
mesh_terms: D000293:Adolescent; D000328:Adult; D015373:Bacterial Typing Techniques / Q000379:methods; D017347:Brucella melitensis / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D002006:Brucellosis / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D010406:Penicillins