title: Phenothiazinium-based photobactericidal materials.
abstract: Photosensitisers based on the phenothiazinium chromophore have been reported to be bactericidal on illumination via a singlet oxygen-mediated mechanism. The current work reports on the immobilisation of the methylene blue analogue, new methylene blue, in polymer resins, and the preliminary development of photobactericidal materials. The resultant materials exhibited measurable levels of singlet oxygen and were photobactericidal against both Staphylococcus epidermidis and Escherichia coli. Such materials may be of use in surface disinfection/infection control in the healthcare milieu.
authors.affiliation: Liverpool School of Pharmacy and Chemistry, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK. mark_wainwright@hotmail.com
authors.forename: Mark
authors.initials: M
authors.lastname: Wainwright
authors.forename: Michael N
authors.initials: MN
authors.lastname: Byrne
authors.forename: Mark A
authors.initials: MA
authors.lastname: Gattrell
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D004203:Disinfection / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D008751:Methylene Blue / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D010640:Phenothiazines / Q000737:chemistry* / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D010640:Phenothiazines; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C035184:new methylene blue; C011238:1,3-diphenylisobenzofuran; D008751:Methylene Blue