title: Breast-feeding duration and childhood acute leukemia and lymphomas in a sample of Turkish children.
abstract: OBJECTIVE
  Whether breast-feeding is associated with decreased incidence of the lymphoid malignancies in children is uncertain. We evaluated childhood acute leukemia and lymphoma in relation to duration of breast-feeding.
  
  
  METHODS
  We investigated this issue in a case-control study comprising 137 patients, aged 1 to 16 years, with acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin or non-Hodgkin lymphoma, in addition to 146 controls matched for age and sex.
  
  
  RESULTS
  The median duration of breast-feeding among patients was shorter than that of controls (10 vs 12 months). Patients with ALL and AML had shorter mean breast-feeding duration compared with healthy children (P = 0.001 and P < 0.001, respectively). The shortest mean breast-feeding duration was noted in the children with AML. Breast-feeding for a duration of 0 to 6 months, when compared with feeding of longer than 6 months, was associated with increased odds ratios (ORs) for ALL [OR = 2.44, 95% confidence interval (CI) = 1.17-5.10], AML (OR = 6.67, 95% CI = 1.32-33.69), Hodgkin lymphoma (OR = 3.33, 95% CI = 0.60-18.54), non-Hodgkin lymphoma (OR = 1.90, 95% CI = 0.68-5.34) and overall (OR = 2.54, 95% CI = 1.51-4.26).
  
  
  CONCLUSIONS
  Our findings suggest that breast-feeding of more than 6 months is protective against childhood lymphoid malignancies, especially for AML and ALL.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Sevin
authors.initials: S
authors.lastname: Altinkaynak
authors.forename: Mukadder Ayse
authors.initials: MA
authors.lastname: Selimoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Turgut
authors.forename: Buket
authors.initials: B
authors.lastname: Kilicaslan
authors.forename: Vildan
authors.initials: V
authors.lastname: Ertekin
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001942:Breast Feeding; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000517:prevention & control*; D008223:Lymphoma / Q000517:prevention & control*; D008297:Male; D012307:Risk Factors; D013997:Time Factors; D014421:Turkey