Death or survival--progesterone-dependent cell fate decisions in the human endometrial stroma.
The human endometrium undergoes cyclical waves of proliferation, differentiation and apoptosis in response to the rise and fall in ovarian oestradiol and progesterone levels. These hormonal responses in endometrial cells must be tightly kept in check to safeguard tissue homeostasis throughout reproductive life. The discovery that differentiating endometrium highly expresses the tumour suppressor p53, the forkhead transcription factor FOXO1, and promyelocytic leukaemia zinc finger protein (PLZF) has provided new insights into the molecular basis of life and death decisions in response to sex steroid hormones.
Brosens
J J
JJ
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London W12 ONN, UK.
Gellersen
B
B
D000818:Animals; D016923:Cell Death / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004717:Endometrium / Q000166:cytology* / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; C495901:TP53 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C092037:ZBTB16 protein, human; D011374:Progesterone; D004958:Estradiol; D000242:Cyclic AMP