title: Bone grafts impregnated with antibiotics as a tool for treating infected implants in orthopedic surgery - one stage revision results.
abstract: Infection of an orthopedic implant is considered a devastating complication, necessitating its complete removal and thorough debridement of the site. Osseous defects are common in such conditions and need to be addressed before a new implant may be inserted. So far bone grafting has been contraindicated in bacterially contaminated areas and could only be performed as soon as all signs of infection have ceased. Usually long term antibiotic treatment and a multitude of surgical interventions within a period of several months is required until a definitive supply can be achieved. Allograft bone may be impregnated with high loads of antibiotics using special incubation techniques. Based on this technology 48 exchange procedures of infected orthopaedic implants were performed in a single stage, all of them without the use of bone cement. There were 37 infected hips, 8 knees and 3 infected osteosyntheses. Two hips required re-revision because of persisting infection, the remaining 46 patients stayed infect free for a period between 1 and 7 years after surgery. No adverse side effects could be found. Incorporation appeared as after grafting with unimpregnated bone grafts. Antibiotic loaded allograft bone is a powerful tool in septic revision surgery, enabling restoration of bone stock, insertion of a new implant and control of infection in a single operation.
authors.affiliation: Orthopaedic Department, Weinviertel Klinikum, Schwerpunktkrankenhaus Mistelbach Liechtensteinstrasse, 67, A-2130, Mistelbach, Austria. winkler@celtis.org
authors.forename: Heinz
authors.initials: H
authors.lastname: Winkler
authors.forename: Karl
authors.initials: K
authors.lastname: Kaudela
authors.forename: Alexander
authors.initials: A
authors.lastname: Stoiber
authors.forename: Franz
authors.initials: F
authors.lastname: Menschik
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D009985:Orthopedics / Q000379:methods*; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012086:Reoperation; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus; D014031:Tobramycin / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D014031:Tobramycin