A novel furanocoumarin from Feroniella lucida exerts protective effect against lipid peroxidation.
The protective effect of Feroniella lucida against lipid peroxidation was investigated. Bioassay-guided separation using rat brain as a model led to the isolation of a new antioxidant furanocoumarin named feroniellamin (6) along with five known coumarins. The structure of 6 was characterized by interpretation of spectroscopic data. Feroniellamin inhibited lipid peroxidation with an IC(50) value of 52 microM.
Phuwapraisirisan
Preecha
P
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Surapinit
Serm
S
Tip-Pyang
Santi
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D011564:Furocoumarins / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D027821:Rutaceae / Q000737:chemistry
D000975:Antioxidants; D011564:Furocoumarins; D010936:Plant Extracts