Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells.
Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.
Atanackovic
Djordje
D
Department of Oncology/Hematology, University Medical Center Hamburg-Eppendorf, Hamburg, and Department of Rheumatology and Clinical Immunology, Charité University Hospital, Humboldt-University of Berlin, Germany. D.Atanackovic@uke.uni-hamburg.de
Schnee
Benjamin
B
Schuch
Gunter
G
Faltz
Christiane
C
Schulze
Julia
J
Weber
Cora S
CS
Schafhausen
Philippe
P
Bartels
Katrin
K
Bokemeyer
Carsten
C
Brunner-Weinzierl
Monika Christine
MC
Deter
Hans-Christian
HC
D000208:Acute Disease; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D002465:Cell Movement; D006801:Humans; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D019713:Receptors, CCR5 / Q000032:analysis; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000032:analysis; D013315:Stress, Psychological / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C515370:CCR7 protein, human; D019002:CD56 Antigen; C063419:CTAGE1 protein, human; D008562:Membrane Glycoproteins; D019713:Receptors, CCR5; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D017493:Leukocyte Common Antigens