title: The impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study.
abstract: BACKGROUND
  The aim of this prospective randomized study was to investigate the necessity and impact of prophylactic antibiotics on postoperative infection complications in elective laparoscopic cholecystectomy.
  
  
  METHODS
  At the time of induction of anesthesia, group A patients (n = 141) received 1 g cefazolin, and group B patients (control; n = 136) received 10 mL isotonic sodium chloride solution. Patients' characteristics and general operative outcomes were compared and analyzed.
  
  
  RESULTS
  The overall rate of infection was 1.1% for total 277 patients (0.7% for group A patients and 1.5% for group B patients). No significant difference in infection complications was found between these 2 groups. Also any risk factors contributing to infection complications could not be found.
  
  
  CONCLUSIONS
  We do not recommend the use of prophylactic antibiotics in elective laparoscopic cholecystectomy because they will not decrease the already-low rate of postoperative infectious complications.
authors.affiliation: Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Taiwan.
authors.forename: Wen-Tsan
authors.initials: WT
authors.lastname: Chang
authors.forename: King-Teh
authors.initials: KT
authors.lastname: Lee
authors.forename: Shih-Chang
authors.initials: SC
authors.lastname: Chuang
authors.forename: Shen-Nien
authors.initials: SN
authors.lastname: Wang
authors.forename: Kung-Kai
authors.initials: KK
authors.lastname: Kuo
authors.forename: Jong-Shyone
authors.initials: JS
authors.lastname: Chen
authors.forename: Pai-Ching
authors.initials: PC
authors.lastname: Sheen
mesh_terms: D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D002437:Cefazolin