title: Dynamic helical CT mammography of breast cancer.
abstract: OBJECTIVE
  The purpose of this study was to determine whether dynamic helical computed tomography (CT)-mammography could assist in selecting the most appropriate surgical method in women with breast cancer.
  
  
  METHODS
  Preoperative contrast-enhanced helical CT scanning of the breast was performed on 133 female patients with suspicion of breast cancer at the same time as clinical, mammographic, and/or ultrasonographic examinations. The patients were scanned in the prone position with a specially designed CT-compatible device. A helical scan was made with rapid intravenous bolus injection (3 ml/s) of 100 ml of iodine contrast material. Three-dimensional maximum intensity projection (MIP) images were reconstructed, and CT findings were correlated with surgical and histopathological findings.
  
  
  RESULTS
  Histopathological analysis revealed 84 malignant lesions and seven benign lesions. The sensitivity, specificity, and accuracy levels of the CT scanning were 94.6%, 58.6%, and 78.9%. Helical scanning alone revealed additional contralateral carcinomas in three of four patients and additional ipsilateral carcinomas in three of five patients. However, the technique gave false-positive readings in 24 patients. The preoperative CT-mammogram altered the surgical method in six patients.
  
  
  CONCLUSIONS
  Dynamic helical CT-mammography in the prone position may be one of the choices of adjunct imaging in patients with suspected breast cancer scheduled for surgery.
authors.affiliation: Department of Radiology, Kyoto City Hospital, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fukushima
authors.forename: Ryuji
authors.initials: R
authors.lastname: Okamura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Taisuke
authors.initials: T
authors.lastname: Morimoto
authors.forename: Yoji
authors.initials: Y
authors.lastname: Urata
authors.forename: Sumio
authors.initials: S
authors.lastname: Mukaihara
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D004867:Equipment Design; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000295:instrumentation; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media