title: Reticular erythematous mucinosis occurring in a brother and sister.
abstract: Reticular erythematous mucinosis (REM) is a rare, primary cutaneous mucinosis clinically characterized by a persistent reticular erythema on the mid chest and mid-upper back, and histologically by a mononuclear cell infiltrate and deposits of mucin in the dermis. To our knowledge, the present report of REM occurring in a Caucasian man and his sister is the first reported case of familial REM. Since a host-specific immune response to unknown antigens may be involved in the pathogenesis of this entity, human leukocyte antigen typing was determined and compared to those reported in autoimmune diseases.
authors.affiliation: Institute of Dermatological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
authors.forename: Ruggero
authors.initials: R
authors.lastname: Caputo
authors.forename: Angelo V
authors.initials: AV
authors.lastname: Marzano
authors.forename: Athanasia
authors.initials: A
authors.lastname: Tourlaki
authors.forename: Maurizio
authors.initials: M
authors.lastname: Marchini
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D008297:Male; D017520:Mucinoses / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D035781:Siblings; D012867:Skin / Q000473:pathology*