The immunobiology of Acanthamoeba keratitis.
Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.
Clarke
Daniel W
DW
Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA.
Niederkorn
Jerry Y
JY
D000048:Acanthamoeba / Q000472:pathogenicity*; D015823:Acanthamoeba Keratitis / Q000276:immunology* / Q000469:parasitology; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D006801:Humans