title: Effects of focal frontal lesions on response inhibition.
abstract: This study examined the performance of 38 normal subjects and 43 patients with focal lesions of the frontal lobes on a simple go-nogo task where the probability of the nogo stimulus was either 75% or 25%. Patients with lesions to the superior medial parts of the frontal lobes, in particular to the left superior portion of Brodmann area 6 (which includes the supplementary motor areas and the premotor areas for the right hand) had an increased number of false alarms (incorrect responses to the nogo stimulus). These results indicate that area 6 is specifically involved in the inhibition of response. Patients with lesions to the right anterior cingulate (areas 24 and 32) were slower and more variable in their reaction time. These findings could be explained by an inability to sustain stimulus-response contingencies. Lesions to the right ventrolateral prefrontal cortex (Brodmann areas 44, 45, 47) also increased the variability of response, perhaps by disrupting monitoring performance.
authors.affiliation: Rotman Research Institute at Baycrest, Toronto, Ontario M6A 2E1, Canada. tpicton@rotman-baycrest.on.ca
authors.forename: Terence W
authors.initials: TW
authors.lastname: Picton
authors.forename: Donald T
authors.initials: DT
authors.lastname: Stuss
authors.forename: Michael P
authors.initials: MP
authors.lastname: Alexander
authors.forename: Tim
authors.initials: T
authors.lastname: Shallice
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Binns
authors.forename: Susan
authors.initials: S
authors.lastname: Gillingham
mesh_terms: D001925:Brain Damage, Chronic / Q000503:physiopathology*; D005625:Frontal Lobe / Q000293:injuries* / Q000503:physiopathology*; D006801:Humans; D009433:Neural Inhibition; D011930:Reaction Time; D013647:Task Performance and Analysis