Influence of thyroxine and n-propylthiouracil on nephro-toxicity of inorganic arsenic in rat.
The effect of hyper or hypoactive thyroid on the renal toxicity of arsenic trioxide has been studied in rats. It was observed that pre-treatment of rats with thyroxine stimulates arsenic excretion in urine. The anti-thyroid drug n-propylthiouracil (PTU), inhibits the accumulation of arsenic in renal tissue. Both treatments affect the renal pathology. Histopathological lesions are less severe in PTU and arsenic-treated rats in comparison to thyroxine and arsenic-treated rats. Ultrastructural studies support light microscopical observations. An adaptive response was noticed against arsenic in PTU pre-treated rats. We attribute this response to decreased glutathione-S-transferase (GSH) activity and increased GSH synthesis in the kidney. A relationship between thyroidal activity and arsenic toxicity is suggested by present observations.
Rana
S V S
SV
Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut-250004, India. sureshvs_rana@yahoo.com
Allen
Tanu
T
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D017209:Apoptosis; D000077237:Arsenic Trioxide; D001152:Arsenicals; D003404:Creatinine / Q000652:urine; D005921:Glomerulonephritis / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006980:Hyperthyroidism / Q000150:complications; D007037:Hypothyroidism / Q000150:complications; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009336:Necrosis; D010087:Oxides / Q000633:toxicity*; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D013956:Antithyroid Agents; D001152:Arsenicals; D010087:Oxides; D014284:Triiodothyronine; D011441:Propylthiouracil; D003404:Creatinine; D005982:Glutathione Transferase; D005978:Glutathione; D013974:Thyroxine; D000077237:Arsenic Trioxide