title: Prevalence, epidemiological aspects and clinical importance of TT virus infection in Slovakia.
abstract: The aim of the study was to assess the prevalence, clinical impact and importance of different risk factors of transmission of TTV infection in Slovakia using two PCR methods. Sera of 426 adult persons were examined. TTV DNA was identified by PCR using primers from N22 and untranslated region (UTR) respectively. The established prevalence of TTV tested with N22 and UTR primers according to patients groups was: acute hepatitis of unknown etiology 4 resp. 28 of 37, acute hepatitis B 3 resp. 29 of 38, chronic hepatitis B 11 resp. 41 of 44, chronic hepatitis C 10 resp. 93 of 102, hemodialysis patients 13 resp. 72 of 72, health care workers 0 resp. 27 of 33, control group 8 resp. 83 of 100. Using N22 primers, TTV infection occurred more frequently in chronic hepatitis B group compared with health care workers, if UTR primers were used the group of hemodialysis patients differed significantly from both acute hepatitis groups, health care workers and controls (p < 0.05). From possible risk factors hemodialysis and transfusion count showed notable differences. Bilirubin and aminotransferase levels did not differ between TTV positive and negative groups. No pathogenetic role of TT virus in liver injury was confirmed.
authors.affiliation: Department of Infectious Diseases, P. J. Safarik University, Faculty of Medicine, Kosice, Slovakia. kristian@fnlp.sk
authors.forename: Pavol
authors.initials: P
authors.lastname: Kristian
authors.forename: Ivan
authors.initials: I
authors.lastname: Schréter
authors.forename: Leonard
authors.initials: L
authors.lastname: Siegfried
authors.forename: Pavol
authors.initials: P
authors.lastname: Jarcuska
authors.forename: Eva
authors.initials: E
authors.lastname: Birosová
authors.forename: Stefan
authors.initials: S
authors.lastname: Porubcin
authors.forename: Alojz
authors.initials: A
authors.lastname: Rajnic
authors.forename: Andrea
authors.initials: A
authors.lastname: Gocalová
mesh_terms: D000328:Adult; D004266:DNA Virus Infections / Q000453:epidemiology* / Q000635:transmission; D005260:Female; D006282:Health Personnel; D006525:Hepatitis, Viral, Human / Q000821:virology; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors; D018154:Slovakia / Q000453:epidemiology; D022783:Torque teno virus; D065227:Transfusion Reaction