Localization of the C3-Like ADP-ribosyltransferase from Staphylococcus aureus during bacterial invasion of mammalian cells.
The C3stau2 exoenzyme from Staphylococcus aureus is a C3-like ADP-ribosyltransferase which possesses no specific receptor-binding domain or translocation unit required for entry in target cells where its substrate is located. Here we show that C3stau2 can reach its target after invasion of staphylococci in eukaryotic cells without needing translocation.
Molinari
Gabriella
G
Department of Microbial Pathogenesis, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany.
Rohde
Manfred
M
Wilde
Christian
C
Just
Ingo
I
Aktories
Klaus
K
Chhatwal
Gursharan S
GS
D036002:ADP Ribose Transferases / Q000032:analysis* / Q000502:physiology; D000818:Animals; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D016253:Microscopy, Immunoelectron; D021381:Protein Transport; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D014774:Virulence
D036002:ADP Ribose Transferases; C479830:C3stau2 protein, Staphylococcus aureus