Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight.
Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.
Masckauchán
T Néstor H
TN
Department of Pathology, OB/GYN and Institute of Cancer Genetics, Columbia University Medical Center, New York, New York, USA.
Kitajewski
Jan
J
D043925:Angiogenesis Inducing Agents; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005136:Eye Proteins / Q000502:physiology*; D051157:Frizzled Receptors / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D012171:Retinal Vessels / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology; D051153:Wnt Proteins / Q000502:physiology*
D043925:Angiogenesis Inducing Agents; D005136:Eye Proteins; D051157:Frizzled Receptors; C081848:NDP protein, human; D009419:Nerve Tissue Proteins; D051153:Wnt Proteins