title: Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal.
abstract: We performed pulsed-field gel electrophoresis (XbaI) on 114 bloodstream isolates of Salmonella enterica serotype Paratyphi A and S. enterica serotype Typhi collected from febrile patients in Kathmandu, Nepal. Of the 56 S. Paratyphi A isolates, 51 (91%) were indistinguishable, which suggests the emergence of a single clone. In contrast, only 21 (36%) of the 58 S. Typhi isolates exhibited a common genotype, which is consistent with endemic disease from multiple sources.
authors.affiliation: Duke University Medical Center, Durham, NC, USA. woods004@mc.duke.edu
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Woods
authors.forename: David R
authors.initials: DR
authors.lastname: Murdoch
authors.forename: Mark D
authors.initials: MD
authors.lastname: Zimmerman
authors.forename: William A
authors.initials: WA
authors.lastname: Glover
authors.forename: Buddha
authors.initials: B
authors.lastname: Basnyat
authors.forename: Leslie
authors.initials: L
authors.lastname: Wolf
authors.forename: Ram Hari
authors.initials: RH
authors.lastname: Belbase
authors.forename: L Barth
authors.initials: LB
authors.lastname: Reller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D010284:Paratyphoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D012482:Salmonella paratyphi A / Q000302:isolation & purification*; D014435:Typhoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D014504:Urban Health
chemical_list: D000890:Anti-Infective Agents