Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1beta and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection.
Lara-Tejero
Maria
M
Section of Microbial Pathogenesis, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA.
Sutterwala
Fayyaz S
FS
Ogura
Yasunori
Y
Grant
Ethan P
EP
Bertin
John
J
Coyle
Anthony J
AJ
Flavell
Richard A
RA
Galán
Jorge E
JE
D000818:Animals; D020170:Caspase 1 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D003092:Colitis / Q000235:genetics / Q000382:microbiology; D017931:DNA Primers; D004198:Disease Susceptibility; D016678:Genome; D007249:Inflammation / Q000201:enzymology / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012480:Salmonella Infections / Q000235:genetics; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000472:pathogenicity*; D013307:Streptomycin / Q000494:pharmacology
D017931:DNA Primers; D020170:Caspase 1; D013307:Streptomycin