Fine-scale map of encyclopedia of DNA elements regions in the Korean population.
The International HapMap Project aims to generate detailed human genome variation maps by densely genotyping single-nucleotide polymorphisms (SNPs) in CEPH, Chinese, Japanese, and Yoruba samples. This will undoubtedly become an important facility for genetic studies of diseases and complex traits in the four populations. To address how the genetic information contained in such variation maps is transferable to other populations, the Korean government, industries, and academics have launched the Korean HapMap project to genotype high-density Encyclopedia of DNA Elements (ENCODE) regions in 90 Korean individuals. Here we show that the LD pattern, block structure, haplotype diversity, and recombination rate are highly concordant between Korean and the two HapMap Asian samples, particularly Japanese. The availability of information from both Chinese and Japanese samples helps to predict more accurately the possible performance of HapMap markers in Korean disease-gene studies. Tagging SNPs selected from the two HapMap Asian maps, especially the Japanese map, were shown to be very effective for Korean samples. These results demonstrate that the HapMap variation maps are robust in related populations and will serve as an important resource for the studies of the Korean population in particular.
Yoo
Yeon-Kyeong
YK
DNA Link, Seoul, 120-110, Korea.
Ke
Xiayi
X
Hong
Sungwoo
S
Jang
Hye-Yoon
HY
Park
Kyunghee
K
Kim
Sook
S
Ahn
TaeJin
T
Lee
Yeun-Du
YD
Song
Okryeol
O
Rho
Na-Young
NY
Lee
Moon Sue
MS
Lee
Yeon-Su
YS
Kim
Jaeheup
J
Kim
Young J
YJ
Yang
Jun-Mo
JM
Song
Kyuyoung
K
Kimm
Kyuchan
K
Weir
Bruce
B
Cardon
Lon R
LR
Lee
Jong-Eun
JE
Hwang
Jung-Joo
JJ
D044466:Asian People / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D004247:DNA / Q000032:analysis; D030561:Databases, Nucleic Acid; D005828:Genetics, Population / Q000379:methods; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic
D004247:DNA