title: COX-2 and sPLA2 inhibitory activity of aqueous extract and polyphenols of Rhizophora mangle (red mangrove).
abstract: The aqueous extract of Rhizophora mangle bark and its polyphenolic fractions showed remarkable in vitro antiinflammatory activity in a preliminary study. The low molecular weight fraction exhibited cyclooxygenase-2 inhibitory activity while the total aqueous extract and the low molecular weight fraction showed secretory phospholipase A(2) inhibitory activity.
authors.affiliation: National Center for Animal and Plant Health, CENSA, Apdo 10, San José de las Lajas, La Habana, Cuba. evadidem@censa.edu.cu
authors.forename: Evangelina
authors.initials: E
authors.lastname: Marrero
authors.forename: Janet
authors.initials: J
authors.lastname: Sánchez
authors.forename: Elizabeth
authors.initials: E
authors.lastname: de Armas
authors.forename: Arturo
authors.initials: A
authors.lastname: Escobar
authors.forename: Gleiby
authors.initials: G
authors.lastname: Melchor
authors.forename: M J
authors.initials: MJ
authors.lastname: Abad
authors.forename: Paulina
authors.initials: P
authors.lastname: Bermejo
authors.forename: Angel M
authors.initials: AM
authors.lastname: Villar
authors.forename: J
authors.initials: J
authors.lastname: Megías
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Alcaraz
mesh_terms: D051546:Cyclooxygenase 2 / Q000187:drug effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000187:drug effects*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols; D043982:Rhizophoraceae
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D004791:Enzyme Inhibitors; D005419:Flavonoids; D008565:Membrane Proteins; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D010741:Phospholipases A