[Inhibition of active transport of calcium ions by PT(IV) and PD(II) metal complexes. Correlation between the process and antimetastatic action of drugs].
Newly synthesized compounds, namely, platinum and palladium metal complexes based on substituted pyridinecarboxylic acids inhibit both active transport of Ca ions and hydrolysis of ATP, catalyzed by sarcoplasmic reticulum Ca(2+)-ATPase. The degree of active transport of Ca ions to vesicles correlated to the inhibition of metastases of experimental melanoma B16 by compounds studied. We suggest that the mechanism responsible for inhibition of metastases by newly synthesized compounds consists in change of normal ratio of extra- and intracellular content of Ca2+ ions that influences platelet aggregation, required for adhesion of metastasizing tumor cells to vascular walls.
Tat'ianenko
L V
LV
Konovalova
N P
NP
Bogdanov
G N
GN
Dobrokhotova
O V
OV
Fedorov
B S
BS
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D002120:Calcium Channel Agonists / Q000494:pharmacology; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000502:physiology; D006868:Hydrolysis; D015640:Ion Channel Gating; D017136:Ion Transport; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D009942:Organometallic Compounds / Q000494:pharmacology*; D010165:Palladium; D010984:Platinum; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D002120:Calcium Channel Agonists; D009942:Organometallic Compounds; D011725:Pyridines; D010984:Platinum; D010165:Palladium; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases; D002118:Calcium