Effect of acute and chronic moderate red or white wine consumption on fasted and postprandial lipemia in the rat.
The effects of acute and chronic (10 wk) red or white wine consumption on fasted and postprandial lipemia in the rat model are reported. Fasted rats, in the acute study, were loaded intragastrically with 5 ml of an olive oil emulsion (30% w/v) in the presence or absence of wine (8% v/v ethanol), and either mesenteric lymph or blood was collected 3 h postprandially. Animals in the chronic study received either red or white wine in drinking water for a period of 10 wk (3% v/v ethanol). Blood samples were collected from animals in either the fasted state or after fat-wine loading. Postprandially, wine delayed gastric emptying, reduced lymph triacylglycerol (TAG) secretion concomitantly with increased number and decreased chylomicron (CM) size, and increased plasma TAG and CM concentrations. Phospholipid and cholesterol contents of CM, but not very-low-density lipoprotein (VLDL), were increased, indicating enhanced liver bile secretion; however, a significant increase in plasma VLDL concentration was observed. In the chronic study, a wine-fat load resulted in increased high-density lipoprotein (HDL) cholesterol concentration and less pronounced postprandial hypertriglyceridemia and hyperchylomicronemia. In the fasted state, plasma TAG and total apolipoprotein B concentrations were not modified in these animals, and an increase in HDL and a decrease in low-density lipoprotein (LDL)/HDL cholesterol ratios were observed. No liver function or intestinal lipid absorption impairment was observed. In conclusion, unlike binge drinking, chronic moderate wine consumption appears to have a cardioprotective effect in the fasted state, an effect attenuated by the observed temporary postprandial hyperchylomicronemia and hypertriglyceridemia resulting from a direct effect of alcohol on CM size and number.
Daher
Costantine F
CF
School of Arts and Sciences, Natural Sciences Division, Biology Department, Lebanese American University, Byblos, Lebanon. cdaher@lau.edu.lb
Slaiby
Rita
R
Haddad
Najib
N
Boustany
Karim
K
Baroody
George M
GM
D000428:Alcohol Drinking; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D004326:Drinking; D005215:Fasting; D005746:Gastric Emptying / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D023421:Models, Animal; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D019518:Postprandial Period; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014920:Wine
D008074:Lipoproteins; D000069463:Olive Oil; D010938:Plant Oils