Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration.
Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q(1) at low concentrations of 0.8 to 3.2 mug/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.
Inatsu
Sakiko
S
Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan.
Ohsaki
Ayumi
A
Nagata
Kumiko
K
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D010084:Oxidation-Reduction; D014451:Ubiquinone / Q000031:analogs & derivatives
D000975:Antioxidants; D016227:Benzoquinones; D014451:Ubiquinone; D000255:Adenosine Triphosphate; C036619:idebenone