title: Coronary vasospasm-induced acute diastolic dysfunction in a patient with Raynaud's phenomenon.
abstract: We present the case of a patient with severe dyspnea and Raynaud's phenomenon. We could clarify, using invasive techniques including left ventricular conductance catheterization and coronary ergonovine provocation, that isolated diastolic dysfunction induced by coronary vasospasm were responsible for the symptoms. Systolic function was not affected. Short-term infusions with the prostacyclin analogue iloprost, known to act as a disease-modifying agent in patients suffering from Raynaud's phenomenon, led to an improvement of cardiac function. Thus, episodes of dyspnea in patients with Raynaud's phenomenon might be also interpreted as a coronary ischemia equivalent, which may belong to a visceral form of Raynaud's phenomenon and which are sensitive to iloprost infusions.
authors.affiliation: Charitè-University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200, Berlin, Germany. Carsten.Tschoepe@charite.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Tschöpe
authors.forename: Dirk
authors.initials: D
authors.lastname: Westermann
authors.forename: Paul
authors.initials: P
authors.lastname: Steendijk
authors.forename: Mario
authors.initials: M
authors.lastname: Kasner
authors.forename: Martin
authors.initials: M
authors.lastname: Rudwaleit
authors.forename: Peter L
authors.initials: PL
authors.lastname: Schwimmbeck
authors.forename: Wolfgang C
authors.initials: WC
authors.lastname: Poller
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schultheiss
mesh_terms: D003329:Coronary Vasospasm / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D003971:Diastole; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications*