title: [Insulin secretion at the diagnosis of gestational diabetes is lower in multiparas than in primiparas].
abstract: Gestational diabetes mellitus (GDM) has heterogeneous ethiopathogenesis, pathophysiology and clinical features.
  
  
  OBJECTIVE
  The aim of the study was to evaluate some of anthropometric parameters, clinical features and indices of insulin resistance and beta cell function in GDM women in first pregnancy and in GDM women in third and following pregnancies.
  
  
  METHODS
  877 GDM women, aged 18-48 years were studied. Both groups were compared according to age, BMI before pregnancy, week of GDM diagnosis, weight gain during pregnancy, fasting blood glucose, fasting serum insulin level, HbA1c, insulin resistance and beta-cell function indices. All parameters except BMI were evaluated at GDM diagnosis.
  
  
  RESULTS
  Multiparas were older, with higher BMI and lower beta-cell function indices.
  
  
  CONCLUSIONS
  At the moment of GDM diagnosis, insulin secretion evaluated by HOMA indices are lower in multiparas in comparison to primaparas.
authors.affiliation: Kameda i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych. alinasokup@o2.pl
authors.forename: Alina
authors.initials: A
authors.lastname: Sokup
authors.forename: Maciej
authors.initials: M
authors.lastname: Swiatkowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Tyloch
authors.forename: Stanisław
authors.initials: S
authors.lastname: Skublicki
authors.forename: Wiesław
authors.initials: W
authors.lastname: Szymanski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Góralczyk
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006304:Health Status; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D018709:Statistics, Nonparametric; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin