IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population.
In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.
Segat
Ludovica
L
Department of Reproductive and Developmental Sciences, University of Trieste, Via dell'Istria 65/1, Trieste, Italy. segat@burlo.trieste.it
Bevilacqua
Daiana
D
Boniotto
Michele
M
Arraes
Luiz C
LC
de Souza
Paulo R
PR
de Lima Filho
Josè L
JL
Crovella
Sergio
S
D001938:Brazil; D002648:Child; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011153:Population / Q000235:genetics; D011401:Promoter Regions, Genetic
D020382:Interleukin-18