title: Prognostic significance of bladder tumor history and tumor location in upper tract transitional cell carcinoma.
abstract: OBJECTIVE
  We studied prognostic factors for 5-year disease specific and recurrence-free survival in patients treated for upper urinary tract transitional cell carcinoma.
  
  
  METHODS
  Since July 1987, 72 patients with a mean age of 58.9 years have undergone nephroureterectomy with bladder cuff excision. Median followup was 62.2 months (range 6 to 192). Patient age, sex, detection duration and mode, bladder tumor history, smoking habit, stone disease history, and tumor stage, grade and location were evaluated as prognostic factors.
  
  
  RESULTS
  Overall 5-year disease specific and recurrence-free survival rates were 74.9% and 67.8%, respectively. Univariate analysis revealed anemia, positive bladder tumor history, T stage, grade and tumor location in the upper tract as significant prognostic factors. On multivariate analysis T stage, grade and tumor location in the urothelium were the only significant variables for the 5-year disease specific and recurrence-free survival rates.
  
  
  CONCLUSIONS
  High tumor stage and grade, and ureteral location were significantly associated with worse disease specific and recurrence-free survival in patients with upper urinary tract transitional cell carcinoma. Our results may help define the patient groups that need adjuvant therapy and they may form a basis for further controlled studies.
authors.affiliation: Department of Urology, Hacettepe University, School of Medicine, Ankara 06700, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Akdogan
authors.forename: Hasan Serkan
authors.initials: HS
authors.lastname: Dogan
authors.forename: Saadettin Yilmaz
authors.initials: SY
authors.lastname: Eskicorapci
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sahin
authors.forename: Ilhan
authors.initials: I
authors.lastname: Erkan
authors.forename: Haluk
authors.initials: H
authors.lastname: Ozen
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D011379:Prognosis; D015996:Survival Rate; D014516:Ureteral Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology*