title: Addition of cisatracurium to lidocaine for intravenous regional anesthesia.
abstract: OBJECTIVE
  To determine the onset and regression time of motor and sensory block, and the quality of anesthesia and postoperative analgesia by the addition of cisatracurium to local anesthetic solution in small doses in intravenous regional anesthesia.
  
  
  METHODS
  Prospective, randomized, double-blind study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  40 ASA physical status I and II patients undergoing elective hand surgery.
  
  
  METHODS
  Intravenous regional anesthesia was achieved using 3 mg/kg lidocaine diluted with saline to a total volume of 40 mL in the control group or 0.01 mg/kg of cisatracurium plus 3 mg/kg lidocaine diluted with saline to a total volume of 40 mL in the cisatracurium group.
  
  
  METHODS
  The onset and the regression time for sensory and motor block were recorded. Quality of anesthesia, intraoperative, and postoperative analgesic requirements were noted. Mean arterial pressure and heart rate were recorded every 5 minutes.
  
  
  RESULTS
  The onset time of sensory and motor block in the cisatracurium group was shorter than in the control group, and the difference was statistically significant. The quality of anesthesia was better in the cisatracurium group than in the control group, and the difference was statistically significant. There was no difference between the two groups with respect to sensory block regression time. Motor block regression time was statistically longer in the cisatracurium group than in the control group. Analgesic requirement was greater in the control group than in the cisatracurium group.
  
  
  CONCLUSIONS
  The addition of cisatracurium to lidocaine in intravenous regional anesthesia shortened the sensory and motor block onset times, improved the quality of anesthesia, and decreased analgesic requirements without causing clinical side effects.
authors.affiliation: Department of Anesthesiology and Reanimation, Erciyes University Medical Faculty, Kayseri, Turkey. aliye@operamail.com
authors.forename: Aliye
authors.initials: A
authors.lastname: Esmaoglu
authors.forename: Aynur
authors.initials: A
authors.lastname: Akin
authors.forename: Ayse
authors.initials: A
authors.lastname: Mizrak
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Turk
authors.forename: Adem
authors.initials: A
authors.lastname: Boyaci
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D001279:Atracurium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D008012:Lidocaine; C101584:cisatracurium