Early nonsense: mRNA decay solves a translational problem.
Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination--or nonsense--codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolve a poorly dissociable termination complex.
Amrani
Nadia
N
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA.
Sachs
Matthew S
MS
Jacobson
Allan
A
D020413:3' Untranslated Regions / Q000378:metabolism; D000818:Animals; D018389:Codon, Nonsense / Q000378:metabolism; D018388:Codon, Terminator / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics*; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D014158:Transcription, Genetic
D020413:3' Untranslated Regions; D018389:Codon, Nonsense; D018388:Codon, Terminator; D012333:RNA, Messenger