[Mechanism of cartilage matrix remodeling by Wnt].
Wnt proteins play central roles in a variety of developmental processes and regulate cell differentiation, cell fate and cell proliferation. It has been also demonstrated that Wnt proteins profoundly participate in cartilage development. Interestingly, activation of Wnt/beta-catenin signaling in chondrocytes induces a profile of matrix degradation enzymes quite similar to that of cartilage matrix degradation such as osteoarthritis and rheumatoid arthritis. In this review we discuss the involvement of Wnt/beta-catenin signaling in pathological cartilage matrix degradation.
Yuasa
Takahito
T
Thomas Jefferson University, Department of Orthopaedic Surgery.
Iwamoto
Motomi Enomoto
ME
D000818:Animals; D002356:Cartilage / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology; D051379:Mice; D051153:Wnt Proteins / Q000502:physiology*
D051153:Wnt Proteins