title: Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol).
abstract: Nano-fibres containing quaternised chitosan (QCh) have been successfully prepared by electrospinning of QCh solutions mixed with poly(vinyl alcohol) (PVA). The average fibre diameter is in the range of 60-200 nm. UV irradiation of the composite electrospun nano-fibrous mats containing triethylene glycol diacrylate as cross-linking agent has resulted in stabilising of the nano-fibres against disintegration in water or water vapours. Microbiological screening has demonstrated the antibacterial activity of the photo-cross-linked electrospun mats against Staphylococcus aureus and Escherichia coli. The obtained nano-fibrous electrospun mats are promising for wound-healing applications.
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
authors.forename: Milena
authors.initials: M
authors.lastname: Ignatova
authors.forename: Kirilka
authors.initials: K
authors.lastname: Starbova
authors.forename: Nadya
authors.initials: N
authors.lastname: Markova
authors.forename: Nevena
authors.initials: N
authors.lastname: Manolova
authors.forename: Iliya
authors.initials: I
authors.lastname: Rashkov
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011145:Polyvinyls; D014867:Water; D011092:Polyethylene Glycols; D048271:Chitosan