title: Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products.
abstract: Conventional neonatal cardiopulmonary bypass requires the use of large volumes of allogeneic blood to prevent unacceptable hemodilution. Evidence is accumulating to suggest that the use of blood products during cardiopulmonary bypass has a negative effect on clinical recovery through inflammatory side effects. This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our laboratory that emphasize the benefits of circuit miniaturization.
authors.affiliation: Division of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Hickey
authors.forename: Tara
authors.initials: T
authors.lastname: Karamlou
authors.forename: Jamie
authors.initials: J
authors.lastname: You
authors.forename: Ross M
authors.initials: RM
authors.lastname: Ungerleider
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D016913:Blood Component Transfusion / Q000009:adverse effects; D019559:Capillary Leak Syndrome / Q000503:physiopathology / Q000517:prevention & control; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling; D016207:Cytokines / Q000378:metabolism; D004867:Equipment Design; D005374:Filtration; D006324:Heart Arrest, Induced / Q000295:instrumentation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007260:Infusion Pumps; D008904:Miniaturization; D034421:Sus scrofa; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D065227:Transfusion Reaction
chemical_list: D016207:Cytokines