title: The composition of crystalline complexes of neurophysin-M with [8-arginine]-vasopressin and oxytocin.
abstract: Neurophysin-M, a methionine-containing protein that is the major constituent of neurophysin, has been crystallized as complexes with [8-arginine]-vasopressin. Three moles of vasopressin alone or 2 moles of vasopressin together with 1 mole of oxytocin are bound/mole of protein. An amorphous complex of the protein with oxytocin alone contains 2 moles of the hormone/mole of protein. Deamino-[8-arginine]-vasopressin, a highly active basic analogue of vasopressin, is not bound by neurophysin. The primary amino group of both vasopressin and oxytocin is necessary for binding with neurophysin.
authors.affiliation: Department of Pharmacology, University of Oxford.
authors.forename: M D
authors.initials: MD
authors.lastname: Hollenberg
authors.forename: D B
authors.initials: DB
authors.lastname: Hope