CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5.
The nuclear hormone receptor coactivator PGC-1alpha is a key regulator of gluconeogenic genes during fasting. In this issue of Cell Metabolism, Puigserver and colleagues (Lerin et al., 2006) report that the histone acetyltransferase GCN5 inhibits gluconeogenesis by acetylating and sequestering PGC-1alpha in nuclear foci.
Liu
Yi
Y
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Montminy
Marc
M
D000107:Acetylation; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D005215:Fasting / Q000378:metabolism*; D005943:Gluconeogenesis / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D015534:Trans-Activators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000099224:p300-CBP-Associated Factor
D006360:Heat-Shock Proteins; D051548:Histone Acetyltransferases; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D015534:Trans-Activators; D014157:Transcription Factors; C486497:PPARGC1A protein, human; C485290:Ppargc1a protein, mouse; C501179:KAT2A protein, human; D000099224:p300-CBP-Associated Factor