Benazepril and subclinical feline hypertrophic cardiomyopathy: a prospective, blinded, controlled study.
Twenty-one cats with hypertrophic cardiomyopathy were enrolled in this study to determine if the administration of benazepril (0.5 mg/kg body weight [BW], PO, q24h) to cats with subclinical hypertrophic cardiomyopathy improves cardiac diastolic function and reverses left ventricular hypertrophy when compared with diltiazem controlled delivery (CD) (10 mg/kg BW, PO, q24h). Cats were evaluated at day 0 and after 3 and 6 months of therapy. In the benazepril group (n = 11), the diastolic transmitral flow of the E and A waves ratio (E/A ratio) increased significantly between 0 and 6 months (P = 0.009) and the thickness of the left ventricular free wall in systole (LVFWs) decreased significantly between 0 and 3 months (P = 0.04). In the diltiazem CD group (n = 5), none of the parameters varied significantly throughout the study. There was no difference between the benazepril and the diltiazem CD group throughout the study. Therefore, the variations observed for the E/A ratio and the LVFWs may have been incidental. Further studies will be needed to establish the role of benazepril in subclinical hypertrophic cardiomyopathy in cat.
Taillefer
Mylène
M
Companion Animal Research Group, Small Animal Veterinary Teaching Hospital, Université de Montréal, 3200, Sicotte Street, PO Box 5000, Saint-Hyacinthe, Quebec J2S 7C6. mylene.taillefer@umontreal.ca
Di Fruscia
Rocky
R
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001552:Benzazepines / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004110:Diltiazem / Q000627:therapeutic use; D004311:Double-Blind Method; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D001552:Benzazepines; D004110:Diltiazem; C044946:benazepril