Navigation ability dependent neural activation in the human brain: an fMRI study.
Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using functional magnetic resonance imaging, we measured brain activity related to navigation in four groups of normal volunteers: good navigators (males and females) and poor navigators (males and females). In a whole group analysis, task related activity was noted in the hippocampus, parahippocampal gyrus, posterior cingulate cortex, precuneus, parietal association areas, and the visual association areas. In group comparisons, good navigators showed a stronger activation in the medial temporal area and precuneus than poor navigators. There was neither sex effect nor interaction effect between sex and navigation ability. The activity in the left medial temporal areas was positively correlated with task performance, whereas activity in the right parietal area was negatively correlated with task performance. Furthermore, the activity in the bilateral medial temporal areas was positively correlated with scores reflecting preferred navigation strategies, whereas activity in the bilateral superior parietal lobules was negatively correlated with them. Our data suggest that different brain activities related to navigation should reflect navigation skill and strategies.
Ohnishi
Takashi
T
Department of Radiology, National Center Hospital of Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1 Ogawa Higashi, Kodaira City, Tokyo 187-8551, Japan. tohnishi@hotmail.com
Matsuda
Hiroshi
H
Hirakata
Makiko
M
Ugawa
Yoshikazu
Y
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology*; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology; D011340:Problem Solving / Q000502:physiology; D012727:Sex Characteristics; D013028:Space Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology