title: Treatment of chronic elbow tendinosis with buffered platelet-rich plasma.
abstract: BACKGROUND
  Elbow epicondylar tendinosis is a common problem that usually resolves with nonoperative treatments. When these measures fail, however, patients are interested in an alternative to surgical intervention.
  
  
  OBJECTIVE
  Treatment of chronic severe elbow tendinosis with buffered platelet-rich plasma will reduce pain and increase function in patients considering surgery for their problem.
  
  
  METHODS
  Cohort study; Level of evidence, 2.
  
  
  METHODS
  One hundred forty patients with elbow epicondylar pain were evaluated in this study. All these patients were initially given a standardized physical therapy protocol and a variety of other nonoperative treatments. Twenty of these patients had significant persistent pain for a mean of 15 months (mean, 82 of 100; range, 60-100 of 100 on a visual analog pain scale), despite these interventions. All patients were considering surgery. This cohort of patients who had failed nonoperative treatment was then given either a single percutaneous injection of platelet-rich plasma (active group, n = 15) or bupivacaine (control group, n = 5).
  
  
  RESULTS
  Eight weeks after the treatment, the platelet-rich plasma patients noted 60% improvement in their visual analog pain scores versus 16% improvement in control patients (P =.001). Sixty percent (3 of 5) of the control subjects withdrew or sought other treatments after the 8-week period, preventing further direct analysis. Therefore, only the patients treated with platelet-rich plasma were available for continued evaluation. At 6 months, the patients treated with platelet-rich plasma noted 81% improvement in their visual analog pain scores (P =.0001). At final follow-up (mean, 25.6 months; range, 12-38 months), the platelet-rich plasma patients reported 93% reduction in pain compared with before the treatment (P <.0001).
  
  
  CONCLUSIONS
  Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation. Further evaluation of this novel treatment is warranted. Finally, platelet-rich plasma should be considered before surgical intervention.
authors.affiliation: Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, 1300 Crane Street, Menlo Park, CA 94025, USA. allan_mishra@yahoo.com
authors.forename: Allan
authors.initials: A
authors.lastname: Mishra
authors.forename: Terri
authors.initials: T
authors.lastname: Pavelko
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001804:Blood Transfusion, Autologous; D002908:Chronic Disease; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement; D017060:Patient Satisfaction; D010865:Pilot Projects; D017713:Platelet Transfusion / Q000379:methods*; D013716:Tennis Elbow / Q000628:therapy*; D016896:Treatment Outcome