[Biochemical markers of bone turnover in children with celiac disease on gluten-free diet].
Celiac disease is known to predispose patients to disturbances in bone metabolism. However, little information is available on the biochemical bone turnover markers in celiac children treated with gluten-free diet.


OBJECTIVE
The aim of presented study was to assess bone resorption and formation processes by biochemical bone turnover markers in children with celiac disease on gluten-free diet.


METHODS
We studied 20 children with celiac disease (age range 1.5 - 16 yr; 11 girls, 9 boys). The mean age of diagnosis was 2.6 +/- 1.9 yr and the mean duration of gluten-free diet was 7.8 +/-5.1 yr. Results were compared with those obtained in 130 healthy children. Serum levels of bone-specific alkaline phosphatase and osteocalcin as bone formation indices and serum level of C-telopeptide of type I collagen as bone resorption index were measured by immunoenzymatic methods. Additionally, serum vitamin D, calcium and phosphorus were also estimated.


RESULTS
Lower median values of C-telopeptide of type I collagen were observed in about 50% tested celiac patients. Some of them also had lower osteocalcin level. However, in most patients ranges of values of bone turnover markers were similar to those in the controls. During our observation, all tested children had normal serum concentration of vitamin D as well as of calcium and phosphorus.


CONCLUSIONS
Our data show normal bone resorption and formation processes in most patients with celiac disease on gluten-free diet. However, some cases had changes in the pattern of bone turnover markers. Further studies of these patients are needed to assess their predisposition to osteopenia and osteoporosis.
Gajewska
Joanna
J
Zakład Biochemii Klinicznej, Instytut Matki i Dziecka, ul. Kasprzaka 17a, 01-211 Warszawa, Poland. biochem@imid.med.pl
Ambroszkiewicz
Jadwiga
J
Hozyasz
Kamil K
KK
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D001862:Bone Resorption / Q000378:metabolism; D002446:Celiac Disease / Q000178:diet therapy* / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D024042:Collagen Type I / Q000097:blood; D018753:Diet, Protein-Restricted; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005983:Glutens; D006801:Humans; D007223:Infant; D008297:Male; D015675:Osteocalcin / Q000097:blood
D015415:Biomarkers; D024042:Collagen Type I; D015675:Osteocalcin; D005983:Glutens; D000469:Alkaline Phosphatase