title: Treatment of ovariectomized ewes with bovine follicular fluid decreases secretion of FSH without changing secretion of LH.
abstract: Ovariectomized ewes were injected with 0, 0.25, 0.5, 1.0 or 2.0 ml of charcoal-extracted bovine follicular fluid. Treating ewes with 2 ml of follicular fluid resulted in a decrease in circulating concentrations of FSH to 72.8% of the pretreatment value. With smaller doses of follicular fluid, the magnitude of the decrease was less. Concentrations of LH did not change significantly. Pretreatment of ovariectomized ewes with estradiol and/or progestogen did not alter the magnitude of the FSH decrease. This action of follicular fluid extract fits the effect of the non-steroidal substance known as inhibin or folliculostatin.
authors.affiliation: U.S. Department of Agriculture Reproduction Laboratory, Animal Science Institute, Agricultural Research Service Beltsville Agricultural Research Center Beltsville, MD 20705 USA.
authors.forename: K F
authors.initials: KF
authors.lastname: Miller
authors.forename: D J
authors.initials: DJ
authors.lastname: Bolt