Difference in susceptibility to activity-based anorexia in two inbred strains of mice.
Food restricted rodents develop activity-based anorexia in the presence of a running wheel, characterised by increased physical activity, weight loss and decreased leptin levels. Here, we determined trait differences in the development of activity-based anorexia between C57BL/6J and DBA/2J inbred mouse lines previously reported as having low and high anxiety, respectively. C57BL/6J mice housed with running wheels and exposed to scheduled feeding reduced their wheel activity, in contrast to DBA/2J mice which exhibited increased behavioural activity under these conditions. Food restriction induced hypoleptinemia in both strains, but the decline in plasma leptin was stronger in DBA/2J mice and correlated with increased activity only in that strain. These data suggest that plasma leptin level dynamics rather than hypoleptinemia alone influences the development of activity-based anorexia and that recombinant inbred panels based on these progenitor lines offer opportunities for the identification of molecular determinants for anorexia nervosa related behavioural traits.
Gelegen
Cigdem
C
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK.
Collier
David A
DA
Campbell
Iain C
IC
Oppelaar
Hugo
H
van den Heuvel
José
J
Adan
Roger A H
RA
Kas
Martien J H
MJ
D000818:Animals; D000855:Anorexia / Q000503:physiopathology / Q000523:psychology*; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D004435:Eating / Q000502:physiology; D005260:Female; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000502:physiology*
D020738:Leptin