title: Effect of autocontrol micromotion intramedullary interlocking nail on fracture healing: an experimental study.
abstract: OBJECTIVE
  To investigate the effect of autocontrol micromotion locking nail (AMLN) on experimental fracture healing and its mechanism.
  
  
  METHODS
  16 goats undergoing both sides of transverse osteotomy of the femoral shafts were fixed intramedullary with AMLN and Gross-Kempf (GK) nail, respectively. The follow-up time was 7, 14, 28 and 56 days. Roentgenographic, biomechanical, histological, scanning electromicroscopic and biochemical analyses were done.
  
  
  RESULTS
  (1) The strength of anticompression, antiflexion and antitorsion in the fractural end in the AMLN-fixed group was higher than that of GK nail-fixed group; whereas, the rate of stress shelter in the fractured end decreased significantly (P<0.01). (2) The content of the total collagen, insoluble collagen, calcium and phosphate in the AMLN-fixed group was higher than that in the GK nail-fixed group (P<0.05). (3) Histological observation and quantitative analysis of calluses revealed that AMLN could promote the growth of bridge calluses and periosteum calluses. Hence the fracture healing and remolding process achieved early, which was much better than traditional GK nail fixation. (P<0.05). (4) 7-14 days postoperation, the calluses of AMLN-fixed group was flourish and camellarly arranged and the collagen fibril formed constantly in the absorption lacuna of bone trabecula. 28-56 days postoperation, the collagen fibril was flourish around the absorption lacuna and was parallel to the bone's longitudinal axis. Active bony absorption and formation were seen, so was remolding and rebuilding. Haversian system was intact and the bony structural net was very tenacious because of the deposition of calcium salt. None of the above findings was observed in the GK nail-fixed group.
  
  
  CONCLUSIONS
  The design of AMLN accords well with the plastic fixation theory. As the geometry ametabolic system constituted by the intramedullary fixation instruments and the proximal and distal end of the fracture is very firm and stable, the disturbance to the physical stress distributed in the fractural end is light. The generation and conduct of the intermittent physical stress between the fractural parts could reach the balance between stress conduct and stress protection. The feature that the healing and remolding take place at the same time speeds up the fractural healing process.
authors.affiliation: Central Hospital of Luohe City, Henan Province, 462000 Luohe, China. hnlhyi@21cn.com
authors.forename: Wei-zhou
authors.initials: WZ
authors.lastname: Xu
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Guo
authors.forename: Ju-cai
authors.initials: JC
authors.lastname: Zhao
authors.forename: Yi-jin
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001858:Bone Nails; D005264:Femoral Fractures / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary / Q000295:instrumentation*; D017102:Fracture Healing / Q000502:physiology*; D006041:Goats; D008855:Microscopy, Electron, Scanning; D013314:Stress, Mechanical