Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 cases.
While hypersexuality and paraphilia are known side effects of anti-Parkinson medications, it is seldom reported. Furthermore, selegiline is rarely implicated in such behaviors. We report two cases of early onset PD who experienced paraphilia and hypersexuality when selegiline was initiated, and later developing obsessive-compulsive and punding behavior with the addition of dopamine agonists. Social repercussions may prohibit patients and/or their families from volunteering such information.
Shapiro
Michael A
MA
Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine, P.O. Box 100236, Gainesville, FL 32610, USA.
Chang
Yu Ling
YL
Munson
Sarah K
SK
Okun
Michael S
MS
Fernandez
Hubert H
HH
D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003192:Compulsive Behavior / Q000139:chemically induced / Q000523:psychology; D004882:Erotica; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D010554:Personality Disorders / Q000139:chemically induced / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012642:Selegiline / Q000009:adverse effects* / Q000627:therapeutic use; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000523:psychology
D000978:Antiparkinson Agents; D012642:Selegiline