A new cytotoxic amide from the stem wood of Hibiscus tiliaceus.
A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N- trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of beta-sitosterol and stigmasterol, a mixture of beta-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, ROC.
Huang
Shi-Yu
SY
Duh
Chang-Yih
CY
Chen
Ih-Sheng
IS
Wang
Tai-Chi
TC
Fang
Hui-Yu
HY
D000178:Acrylamides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D031584:Hibiscus / Q000737:chemistry*; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
D000178:Acrylamides; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D003603:Cytotoxins; D062385:Hydroxybenzoates; C515795:N-(4-hydroxy-3,5-dimethoxyphenethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide; D010936:Plant Extracts; D013256:Steroids; C515794:hibiscusin; D006139:Guaiacol