title: Suzuki coupling of oxazoles.
abstract: A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. [reaction: see text]
authors.affiliation: University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, U.K.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ferrer Flegeau
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Popkin
authors.forename: Michael F
authors.initials: MF
authors.lastname: Greaney