title: [Animal model of eating disorders].
abstract: Patients with eating disorders are increasing in number. Some neurocircuits concerned with feeding behavior might be dysfunctional in these patients with repeated expression of disorganized eating behavior like long-lasting dieting. These neuronal, or endocrinological dysfunctions might even be enhanced by psychological stress. To understand the biological bases of eating disorders is necessary to establish effective treatment. According to the clinical features of the patients, we have conducted some rat studies. We have found that space restriction stress enhances rebound hyperphagia induced by time-restricted scheduled feeding, and propose the phenomenon as a possible rat model of binge eating. We can speculate some part of the biological bases of human eating disorders, and effective prevention and treatment through such animal models.
authors.affiliation: Department of Neuropsychiatry, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. kokii@med.osaka-cu.ac.jp
authors.forename: Koki
authors.initials: K
authors.lastname: Inoue
authors.forename: Shinichi
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kiriike
mesh_terms: D000818:Animals; D000855:Anorexia / Q000523:psychology; D004195:Disease Models, Animal; D001068:Feeding and Eating Disorders / Q000523:psychology*; D006801:Humans; D006963:Hyperphagia / Q000523:psychology; D051381:Rats