Isochromosome 1q in a myelodysplastic syndrome after treatment for acute promyelocytic leukemia.
A growing body of literature reports therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) in patients treated successfully for acute promyelocytic leukemia (APL). We report a t-MDS with an isochromosome 1q as a sole abnormality, 47,XY,+1,i(1)(q10), in a 46-year-old man with APL 14 years after he was treated with cytosine arabinosine and daunorubicin. The literature on t-MDS/t-AML after APL therapy and on isochromosome 1q is reviewed.
Pawarode
Attaphol
A
Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Finlay
Esme
E
Sait
Sheila N J
SN
Barcos
Maurice
M
Baer
Maria R
MR
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure; D003561:Cytarabine / Q000009:adverse effects*; D003630:Daunorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D018404:Isochromosomes; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics*
D000970:Antineoplastic Agents; D003561:Cytarabine; D003630:Daunorubicin