title: Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases.
abstract: We describe the clinicopathological and immunohistochemical features of three spindle (sarcomatoid) basaloid squamous carcinomas in three men aged 73, 69, and 59 years with a history of tobacco and alcohol abuse. Two tumors were located in the hypopharynx and one was located in the nasal cavity. The three tumors have a pedunculated polypoid appearance. Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor. The sarcomatoid component demonstrated immunoreactivity with one or more epithelial markers. One case in addition expressed CD99 and Bcl-2 and was originally diagnosed as monophasic synovial sarcoma; however, a subsequent biopsy disclosed basaloid squamous cell carcinoma with sarcomatoid stroma. Two patients were treated with surgery and radiation whereas one refused therapy. The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis. In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise. The type of epithelial component would determine the subtype of sarcomatoid carcinoma.
authors.affiliation: Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, 77030, USA.
authors.forename: Basel
authors.initials: B
authors.lastname: Altrabulsi
authors.forename: Fernando
authors.initials: F
authors.lastname: Carrizo
authors.forename: Mario A
authors.initials: MA
authors.lastname: Luna
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D002281:Carcinoma, Basosquamous / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D007013:Hypopharynx / Q000473:pathology*; D007150:Immunohistochemistry; D007825:Laryngectomy; D008297:Male; D008437:Maxilla / Q000601:surgery; D008441:Maxillary Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor