title: Decreasing invasive pneumococcal disease in the elderly: a state-level analysis.
abstract: Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.
authors.affiliation: Division of Health Services Research and Policy, University of Minnesota School of Public Health, MMC 97 A369 Mayo Memorial Building, 420 Delaware St., S.E., Minneapolis, MN 55455, USA. mcbea002@umn.edu
authors.forename: A Marshall
authors.initials: AM
authors.lastname: McBean
authors.forename: Kyoungrae
authors.initials: K
authors.lastname: Jung
authors.forename: Paul L
authors.initials: PL
authors.lastname: Hebert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000627:therapeutic use; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D022401:Meningococcal Vaccines / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D012044:Regression Analysis; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D007252:Influenza Vaccines; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines