Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract.
A dichloromethane extract of Isatis tinctoria was tested in the adjuvant-induced arthritis model in rats. The extract (150 mg/kg p. o.) leads to a significant reduction of paw oedema. Radiographic, histological and clinical assessment confirmed reduced damage of cartilage and signs of inflammatory response in comparison to untreated control. No significant differences were observed in the tissular levels of cyclooxygenases 1 and -2, and of inducible nitric oxide synthase in Isatis treated and untreated animals. High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa.
Recio
María-Carmen
MC
Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain.
Cerdá-Nicolás
Miguel
M
Hamburger
Matthias
M
Ríos
José-Luis
JL
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D031219:Isatis; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011859:Radiography; D051381:Rats; D011917:Rats, Inbred Lew
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts