title: Markers of endothelial damage in patients on hemodialysis and hemodiafiltration.
abstract: BACKGROUND
  The purpose of the study was to assess whether renal replacement therapy (RRT) in the form of hemodialysis (HD) or hemodiafiltration (HDF) affects hemostasis and endothelial function in patients with end-stage renal failure (ESRF).
  
  
  METHODS
  Thirty-five hemodialyzed patients and 14 HDF patients were evaluated regarding hemostatic parameters, serum lipids and endothelial cell injury markers.
  
  
  RESULTS
  HD patients did not differ significantly in regard to serum lipids, complete blood count, hemostasis, and dialysis adequacy as measured by Kt/V when compared to HDF patients. Only the markers of endothelial cell injury thrombomodulin and von Willebrand factor were significantly higher in HD when compared to HDF.
  
  
  CONCLUSIONS
  Patients on HD showed evidence of a higher degree of endothelial dysfunction than HDF patients. HDF seems to ameliorate endothelial dysfunction in comparison with HD. Therefore, hemostatic abnormalities in ESRF might be affected to some extent by the choice of RRT.
authors.affiliation: Department of Nephrology and Transplantology, Medical University, Bialystok, Poland. jackmaly@poczta.onet.pl
authors.forename: Jacek S
authors.initials: JS
authors.lastname: Małyszko
authors.forename: Jolanta
authors.initials: J
authors.lastname: Małyszko
authors.forename: Tomasz
authors.initials: T
authors.lastname: Hryszko
authors.forename: Piotr
authors.initials: P
authors.lastname: Koźminski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pawlak
authors.forename: Michal
authors.initials: M
authors.lastname: Mysliwiec
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000293:injuries* / Q000378:metabolism*; D005260:Female; D017583:Hemodiafiltration / Q000009:adverse effects*; D006487:Hemostasis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D008297:Male
chemical_list: D015415:Biomarkers