title: 8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs).
abstract: A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs.
authors.affiliation: Institute of Functional Molecule, School of Chemistry, South China University of Technology, Guangzhou, China. zenghp@scnu.edu.cn
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Zeng
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Ouyang
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Zhou
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Jing
authors.forename: Guo-Zan
authors.initials: GZ
authors.lastname: Yuan
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Shao-Hui
authors.initials: SH
authors.lastname: Du
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D005434:Flow Cytometry; D007118:Immunoassay; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
chemical_list: D015125:Oxyquinoline