title: Comprehensive cardiac assessment with multislice computed tomography: evaluation of left ventricular function and perfusion in addition to coronary anatomy in patients with previous myocardial infarction.
abstract: OBJECTIVE
  To evaluate a comprehensive multislice computed tomography (MSCT) protocol in patients with previous infarction, including assessment of coronary artery stenoses, left ventricular (LV) function and perfusion.
  
  
  METHODS
  16-slice MSCT was performed in 21 patients with previous infarction; from the MSCT data, coronary artery stenoses, (regional and global) LV function and perfusion were assessed. Invasive coronary angiography and gated single-photon emission computed tomography (SPECT) served as the reference standards for coronary artery stenoses and LV function/perfusion, respectively.
  
  
  RESULTS
  236 of 241 (98%) coronary artery segments were interpretable on MSCT. The sensitivity and specificity for detection of stenoses were 91% and 97%. Pearson's correlation showed excellent agreement for assessment of LV ejection fraction between MSCT and SPECT (49 (13)% v 53 (12)%, respectively, r = 0.85). Agreement for assessment of regional wall motion was excellent (92%, kappa = 0.77). In 68 of 73 (93%) segments, MSCT correctly identified a perfusion defect as compared with SPECT, whereas the absence of perfusion defects was correctly detected in 277 of 284 (98%) segments.
  
  
  CONCLUSIONS
  MSCT permits accurate, non-invasive assessment of coronary artery stenoses, LV function and perfusion in patients with previous infarction. All parameters can be assessed from a single dataset.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Henneman
authors.forename: J D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.forename: H J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: A
authors.initials: A
authors.lastname: de Roos
authors.forename: P
authors.initials: P
authors.lastname: Dibbets
authors.forename: M P
authors.initials: MP
authors.lastname: Stokkel
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: J J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000473:pathology