title: Extended use of a new continuous glucose monitoring system with wireless data transmission in children with type 1 diabetes mellitus.
abstract: BACKGROUND
  A new continuous glucose monitoring system (CGMS Datalogger, Medtronic MiniMed, Northridge, CA) potentiates extended sensor use by eliminating the cable connection to a monitor and by being waterproof. We evaluated the performance, safety, and patient tolerance of using the CGMS for 7 continuous days in children with type 1 diabetes mellitus who were encouraged to participate fully in their usual sports and activities in their home environment.
  
  
  METHODS
  Twenty pediatric subjects (12.2 +/- 4.6 years old [mean +/- SD] and glycosylated hemoglobin of 8.06 +/- 1.22%) wore two CGMS devices simultaneously for 7 days. Sensor function was assessed by paired sensor-meter values obtained from the CGMS and their Paradigm Link (Medtronic Minimed) home glucose meter and a daily patient log of sensor and Datalogger sites.
  
  
  RESULTS
  Subjects were wearing 90% of the sensors at the end of 7 days. The devices were well tolerated except for pruritus at the adhesive sites in 29% of subjects, and one sensor site (3%) became infected. Once a correction was made to the connection between the cable and Datalogger, 89% of the 18 sensors that initialized were functional at the end of 5 days [r = 0.91; percent mean absolute relative difference (%MARD) = 12.4%], and 78% were functioning at the end of 7 days (r = 0.91; %MARD s 15.4%). Patient comfort while wearing the device decreased after 5 days of sensor wear.
  
  
  CONCLUSIONS
  This study demonstrates that the life of the glucose sensor can be extended well beyond the current labeling of 72 h. Once the cable connection was corrected, there was no statistically significant change in sensor performance over 7 days. Patients preferred to wear the device for a maximum of 5-6 days.
authors.affiliation: Stanford University School of Medicine, Stanford, California 94305-5208, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Wong
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Buckingham
authors.forename: Betsy
authors.initials: B
authors.lastname: Kunselman
authors.forename: Emil
authors.initials: E
authors.lastname: Istoc
authors.forename: Jacob
authors.initials: J
authors.lastname: Leach
authors.forename: Richard
authors.initials: R
authors.lastname: Purvis
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000009:adverse effects / Q000295:instrumentation*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D017060:Patient Satisfaction; D011537:Pruritus / Q000209:etiology; D013997:Time Factors
chemical_list: D001786:Blood Glucose