The Acre Project: the epidemiology of malaria and arthropod-borne virus infections in a rural Amazonian population.
The authors describe the baseline malaria prevalence and arbovirus seroprevalence among 467 subjects in an ongoing cohort study in rural Amazonia. Most subjects (72.2%) reported one or more previous episodes of malaria, and 15.6% had been hospitalized for malaria, but only 3.6% of individuals five years or older had malaria parasites detected by microscopy (10 with Plasmodium vivax and 4 with P. falciparum). Antibodies to Alphavirus, Orthobunyavirus, and/or Flavivirus were detected by hemagglutination inhibition (HI) in 42.6% of subjects aged five years or older, with a higher seropositivity rate among males (49.2%) than females (36.2%). Since 98.9% of subjects had been immunized for yellow fever, the presence of cross-reactive antibodies to dengue and other Flaviviruses cannot be ruled out, but at least 12 subjects (3.3%) with IgM antibodies to dengue virus detected by ELISA had a putative recent exposure to this virus.
Silva-Nunes
Mônica da
Md
Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Malafronte
Rosely dos Santos
Rdos S
Luz
Bruna de Almeida
Bde A
Souza
Estéfano Alves de
EA
Martins
Lívia Carício
LC
Rodrigues
Sueli Guerreiro
SG
Chiang
Jannifer Oliveira
JO
Vasconcelos
Pedro Fernando da Costa
PF
Muniz
Pascoal Torres
PT
Ferreira
Marcelo Urbano
MU
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001102:Arbovirus Infections / Q000453:epidemiology* / Q000276:immunology; D001103:Arboviruses / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D003716:Dengue Virus / Q000276:immunology; D017753:Ecosystem; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008288:Malaria / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012424:Rural Population; D016036:Seroepidemiologic Studies; D012737:Sex Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G