Cycloleonuripeptides E and F, cyclic nonapeptides from Leonurus heterophyllus.
Two new cyclic nonapeptides, cycloleonuripeptide E, cyclo (-Ala-Pro-Ile-Val-Ala-Ala-Phe-Thr-Pro-), and cycloleonuripeptide F, cyclo (-Gly-Tyr-Pro-Leu-Pro-Phe-Tyr-Pro-Pro-), have been isolated from the fruits of Leonurus heterophyllus, and their structures were elucidated by 2D NMR analysis and chemical degradation. Cycloleonuripeptides E (1) and F (2) showed moderate vasorelaxant effects on rat aorta.
Morita
Hiroshi
H
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
Iizuka
Toru
T
Gonda
Akira
A
Itokawa
Hideji
H
Takeya
Koichi
K
D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D010456:Peptides, Cyclic; D010940:Plant Proteins; D014665:Vasodilator Agents; C511671:cycloleonuripeptide E; C511672:cycloleonuripeptide F