title: Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle.
abstract: BACKGROUND
  Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo).
  
  
  RESULTS
  By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -4241A>T showed significant associations with CW and EMA.
  
  
  CONCLUSIONS
  Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, 153-803, Korea. chhs@snp-genetics.com
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Du-Hak
authors.initials: DH
authors.lastname: Yoon
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Yoo Hyun
authors.initials: YH
authors.lastname: Choi
authors.forename: Eui Ryong
authors.initials: ER
authors.lastname: Chung
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Cho
authors.forename: Eng Woo
authors.initials: EW
authors.lastname: Park
authors.forename: Il-Cheong
authors.initials: IC
authors.lastname: Cheong
authors.forename: Sung-Jong
authors.initials: SJ
authors.lastname: Oh
authors.forename: Sung-Gon
authors.initials: SG
authors.lastname: Yi
authors.forename: Taesung
authors.initials: T
authors.lastname: Park
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000235:genetics*; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000235:genetics*; D007723:Korea; D015810:Linkage Disequilibrium; D008297:Male; D008460:Meat / Q000592:standards*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable
chemical_list: D013007:Growth Hormone-Releasing Hormone