[Relationship between the proliferation and immunoinduction of epithelial cells and the destruction of hair follicles and sebaceous glands in keloids].
OBJECTIVE
To investigate the influence of biological behavior of epithelial cells on the hair follicles and sebaceous glands (HFSG) structure in keloids (K).


METHODS
The expression of intercellular adhesion molecule (ICAM)-1, D-related human leucocyte antigen (HLA-DR), and cytokeratin (CK) 14 on epithelial cells and the amount of activity T-lymphocytes were detected in specimens of keloid edge and normal skin with immunohistochemical and histological methods.


RESULTS
In comparison with normal skin specimens, epithelial cells were proliferated in K-HFSG presented structural aberration and disintegrate or abnormally to form solid-epithelial island-like structure, and the density of HSFG with hyperplasia and the ageing scar in keloids was apparently decreased. They strongly expressed ICAM-1, HLA-DR, and CK14 in the epithelial cells, there were many immunologic cells which expressed CD4, CD45RO, and interferon (IFN)-gamma around the K-HFSG. The expressed level of epithelial cells was positively correlated with the density of immunologic cells nearby K-HFSG.


CONCLUSIONS
It could be concluded that the reactivity with hyperplasia and immunoinduction of epithelial cells might be associated with the destruction of the some HFSG structure in the keloids.
Jiang
Du-yin
DY
The Department of Plastic and Reconstructive Surgery, 2ed Affiliated Hospital, Nanjing Medical University, China.
Fu
Xiao-bing
XB
Sheng
Zhi-yong
ZY
Chen
Wei
W
Sun
Tong-zhu
TZ
D000293:Adolescent; D000328:Adult; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007627:Keloid / Q000276:immunology* / Q000473:pathology*; D053547:Keratin-14 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012627:Sebaceous Glands / Q000473:pathology*; D055815:Young Adult
D006684:HLA-DR Antigens; D053547:Keratin-14; D018799:Intercellular Adhesion Molecule-1