title: [Non-small cell lung cancer (NSCLC): the evolution of neo-adjuvant chemotherapy in the last 15 years].
abstract: Retrospective analysis of surgical data-base of NSCLC have showed that, except stage IA, the prognosis of locally advanced disease is very poor if treated with surgery and/or radiotherapy and it is probably due to distant micrometastasis present at the diagnosis. The aim of neo-adjuvant chemotherapy is to address early the distant micrometastasis and to allow, through a downstaging, surgical resection of tumor not suitable to surgery or partially respectable at diagnosis.
authors.affiliation: Divisione Clinicizzata di Oncologia Medica, Ospedale Civile Maggiore, Verona. antonio.santo@univr.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Santo
authors.forename: Giovenzio
authors.initials: G
authors.lastname: Genestreti
authors.forename: Elena
authors.initials: E
authors.lastname: Fiorio
authors.forename: Alberto
authors.initials: A
authors.lastname: Terzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lonardoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Calabrò
authors.forename: Barbara
authors.initials: B
authors.lastname: Campaldini
authors.forename: Panfilo
authors.initials: P
authors.lastname: Colaluca
authors.forename: Annamaria
authors.initials: A
authors.lastname: Molino
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Cetto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000601:surgery; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome