Evaluation of antifungal properties of octyl gallate and its synergy with cinnamaldehyde.
The objective of this study was to investigate the possibility of using octyl gallate alone or with organic biocides as a preservative against wood decay fungi. Antifungal activities of three antioxidants, propyl gallate, octyl gallate and butylated hydroxyltoluene (BHT) were tested against four wood decay fungi, Lenzites betulina, Trametes versicolor, Gloeophyllum trabeum and Laetiporus sulphureus. Octyl gallate was found to be the only active compound with IC50 values of 0.47, 0.16, 0.24 and 0.04 mM against L. betulina, T. versicolor, G. trabeum and L. sulphureus, respectively. A synergistic effect was also found when octyl gallate was combined with cinnamaldehyde. Results obtained herein demonstrated that octyl gallate by itself exhibited an excellent antifungal property and enhanced protection was further observed by combining it with cinnamaldehyde.
Hsu
Fu-Lan
FL
School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan, ROC.
Chang
Hui-Ting
HT
Chang
Shang-Tzen
ST
D000171:Acrolein / Q000031:analogs & derivatives* / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D016166:Free Radical Scavengers; C016627:octyl gallate; D005707:Gallic Acid; D000171:Acrolein; C012843:cinnamaldehyde