title: Tissue engineering a clinically useful extracellular matrix biomaterial.
abstract: Implantable biomaterials are one of the most useful tools in the surgeon's armamentarium, yet there is much room for improvement. Chronic pain, tissue erosion, and late infections are just a few of the serious complications that can occur with conventional, inert materials. In contrast, tissue-inductive materials exist today. Combinations of biologically important molecules for directing cell growth and providing structural stability can be found in naturally occuring extracellular matrices. These "soft-tissue skeletons" of Mother Nature can be harvested, processed, and provided in a medically safe and biologically active form for repairing many different tissues in the human body. The future of surgical practice may well be determined by how well these new implant materials recreate the tissues they replace.
authors.affiliation: Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. hiles@cookbiotech.com
authors.forename: Michael
authors.initials: M
authors.lastname: Hiles
authors.forename: Jason
authors.initials: J
authors.lastname: Hodde
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D040761:Biomimetic Materials; D005109:Extracellular Matrix; D006801:Humans; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials