[Commonality of molecular mechanisms of neuroplasticity and neuropathology: integrative approach].
Analysis of our own data and of the results from other groups brings about a concept concerning community of the basic molecular mechanisms involved in neuroplasticity and neuropathology at different levels. Along with the fundamental significance of this idea for understanding of processes taking place both in normal brain and in neuropathological conditions, the concept is of principal importance for practical application. Failure in development of the "pathogenetically directed" approaches to treatment of neural diseases (e. g. stroke) are, in particular, related to the neglecting of identity of the basic molecular mechanism underlying both normal brain functioning and neuropathological conditions resulting in intervention into these common mechanisms (NMDA receptors blockade, inhibitor of the so called "apoptotic" proteases).
Balaban
P M
PM
Guliaeva
N V
NV
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008959:Models, Neurological; D009420:Nervous System / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology*; D009473:Neuronal Plasticity; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate