Sperm cryopreservation in male infertility due to genetic disorders.
Certain chromosomal and genetic anomalies, such as Klinefelter syndrome (47,XXY) and Y chromosome microdeletions, have been reported as potential causes of a progressive impairment of spermatogenesis. In these cases cryoconservation of ejaculated or testicular sperm represent a valuable tool for the preservation of fertility. However, dealing with genetic disorders, the transmission of genetic anomalies has to be taken into consideration. It is therefore important to be aware about the clinical importance and the related genetic risks of these anomalies. In this article we describe the clinical significance of these diseases.
Krausz
Csilla
C
Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, Firenze, Italy. c.krausz@dfc.unifi.it
Forti
Gianni
G
D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D015925:Cryopreservation; D005544:Forecasting; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007713:Klinefelter Syndrome / Q000235:genetics; D008297:Male; D008954:Models, Biological; D013076:Sperm Count; D013091:Spermatogenesis / Q000235:genetics; D013094:Spermatozoa / Q000502:physiology*