title: Diosgenin glucuronides from Solanum lyratum and their cytotoxicity against tumor cell lines.
abstract: Bioassay-directed fractionation of the cytotoxicity active fraction of the whole plant from Solanum lyratum led to the isolation of a new steroidal saponin, diosgenin 3-O-beta-D-glucopyranosiduronic acid methyl ester (2), as well as four known compounds, diosgenin (1), diosgenin 3-O-beta-D-glucopyranosiduronic acid (3), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosiduronic acid (4), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucuroniduronic acid methyl ester (5). The structures of the isolated compounds were elucidated on the basis of their spectral data and chemical evidences. Compound 1 was isolated for the first time from this plant, and compound 3 was isolated as a new natural product. Cytotoxic activities of the isolated compounds were evaluated and the cytotoxicities of compounds 2-5 reported for the first time.
authors.affiliation: College of Pharmacy, Shenyang Pharmaceutical University, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Sun
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Fu
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Kai-Shun
authors.initials: KS
authors.lastname: Bi
authors.forename: Min-Wei
authors.initials: MW
authors.lastname: Wang
mesh_terms: D000085:Acetates; D000473:Alkanes; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004144:Diosgenin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000431:Ethanol; D020719:Glucuronides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry*; D032322:Solanum / Q000737:chemistry*
chemical_list: D000085:Acetates; D000473:Alkanes; D020719:Glucuronides; D000431:Ethanol; C007650:ethyl acetate; D004144:Diosgenin; C004544:naphtha