title: Relaxin has a role in establishing a renal response in pregnancy.
abstract: Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl) and plasma osmolality (P(osm)). All pregnancies were associated with increasing CrCl and reduced P(osm), but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy.
authors.affiliation: School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, Tyne and Wear, United Kingdom. m.c.smith@ncl.ac.uk
authors.forename: Marie C
authors.initials: MC
authors.lastname: Smith
authors.forename: Alison P
authors.initials: AP
authors.lastname: Murdoch
authors.forename: Lee A
authors.initials: LA
authors.lastname: Danielson
authors.forename: Kirk P
authors.initials: KP
authors.lastname: Conrad
authors.forename: John M
authors.initials: JM
authors.lastname: Davison
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood*; D005246:Feedback / Q000502:physiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D008657:Metabolic Clearance Rate; D011247:Pregnancy / Q000097:blood*; D012065:Relaxin / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D012065:Relaxin; D003404:Creatinine