AA amyloidosis complicating hyperimmunoglobulinemia D with periodic fever syndrome: a report of two cases.
AA amyloidosis is the most serious potential complication of the inherited autoinflammatory syndromes and frequently results in end-stage renal failure. Although this complication is well recognized in familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, and Muckle-Wells syndrome, there is only 1 previous published report of its occurrence in hyperimmunoglobulinemia D with periodic fever syndrome (HIDS). We report 2 further cases of patients with AA amyloidosis in HIDS, both of whom developed dialysis-dependent renal failure, and we describe the outcome of the first renal transplant in this setting.
Lachmann
Helen J
HJ
Royal Free and University College Medical School, London, UK. h.lachmann@medsch.ucl.ac.uk
Goodman
Hugh J B
HJ
Andrews
Peter A
PA
Gallagher
Hugh
H
Marsh
James
J
Breuer
Stephan
S
Rowczenio
Dorota M
DM
Bybee
Alison
A
Hawkins
Philip N
PN
D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D010505:Familial Mediterranean Fever / Q000150:complications*; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D000685:Serum Amyloid A Protein
D007072:Immunoglobulin D; D000685:Serum Amyloid A Protein