title: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl.
abstract: Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a rare benign proliferation of mesenchymal stromal cells with irregular slit-like formations resembling angiomatous structures. In the majority of cases this lesion is a focal microscopic finding in breast biopsies performed for benign or malignant diseases. It may present in a pure diffuse or nodular form. The exact etiology and pathogenesis of this tumor-like lesion is still unknown, but a proliferative response of myofibroblasts to hormonal stimuli has been postulated. A large 12 x 9 x 3.5 cm rapidly growing nodular form of PASH of the breast in an 18-year-old woman is here described with clinical and histological findings. A possible hormonal etiology was indicated by elevated progesterone (three-fold) and decreased estrogen serum levels. Different diagnostic lesions, such as giant fibroadenoma and low-grade angiosarcoma, are discussed. To the authors' knowledge this is only the fourth case of nodular PASH of the breast reported in the English literature.
authors.affiliation: Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. zubor@jfmed.uniba.sk
authors.forename: P
authors.initials: P
authors.lastname: Zúbor
authors.forename: K
authors.initials: K
authors.lastname: Kajo
authors.forename: C A
authors.initials: CA
authors.lastname: Dussan
authors.forename: N
authors.initials: N
authors.lastname: Szunyogh
authors.forename: J
authors.initials: J
authors.lastname: Danko
mesh_terms: D000293:Adolescent; D000858:Anovulation; D001940:Breast / Q000166:cytology* / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000473:pathology; D009379:Neoplasms, Muscle Tissue / Q000473:pathology*; D011374:Progesterone / Q000097:blood; D017154:Stromal Cells / Q000473:pathology
chemical_list: D011374:Progesterone