Why the transdermal delivery of selegiline (6 mg/24 hr) obviates the need for a dietary restriction on tyramine.
Preskorn
Sheldon H
SH
Department of Psychiatry, University of Kansas School of Medicine-Wichita, KS, USA.
D000279:Administration, Cutaneous; D000818:Animals; D003866:Depressive Disorder / Q000188:drug therapy*; D004032:Diet; D018565:Food-Drug Interactions; D006168:Guinea Pigs; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012642:Selegiline / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014439:Tyramine / Q000378:metabolism*
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D014439:Tyramine