Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.
Serena
Carolina
C
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, Reus, Spain.
Gilgado
Félix
F
Mariné
Marçal
M
Pastor
F Javier
FJ
Guarro
Josep
J
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy* / Q000401:mortality; D011743:Pyrimidines / Q000627:therapeutic use*; D013154:Spleen / Q000382:microbiology; D016019:Survival Analysis; D014230:Triazoles / Q000627:therapeutic use*; D014250:Trichosporon / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole