title: Comparison of glomerular filtration rate between greyhounds and non-Greyhound dogs.
abstract: Greyhounds have significantly higher serum creatinine (SCr) concentration than do non-Greyhound dogs that may be attributable to differences in glomerular filtration rate (GFR). By means of plasma clearance of technetium Tc 99m diethylenetriaminepentaacetic acid, GFR was measured in 10 Greyhounds and 10 non-Greyhound dogs with normal findings of physical examination, CBC, serum biochemical analysis, and urinalysis. Dogs were fed the same diet for a minimum of 6 weeks before GFR data collection. Greyhounds had significantly higher mean +/- SD GFR (3.0 +/- 0.1 vs 2.5 +/- 0.2 ml/min/ kg; P = .01) and SCr concentration (1.8 +/- 0.1 vs 1.5 +/- 0.1 mg/dL; P = .03) than did non-Greyhound dogs, but the serum urea nitrogen (SUN) concentration was not significantly different (18 +/- 1 vs 18 +/- 2 mg/dL; P = .8). Therefore, the higher SCr concentration in Greyhounds is not attributable to decreased GFR, and may be associated with the high muscle mass in the breed. Healthy Greyhounds have higher GFR than do non-Greyhound dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA. drost.2@osu.edu
authors.forename: Wm Tod
authors.initials: WT
authors.lastname: Drost
authors.forename: C Guillermo
authors.initials: CG
authors.lastname: Couto
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Fischetti
authors.forename: John S
authors.initials: JS
authors.lastname: Mattoon
authors.forename: Cristina
authors.initials: C
authors.lastname: Iazbik
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs / Q000097:blood / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology / Q000662:veterinary*; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D010375:Pedigree; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate