FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738. I. Taxonomy, fermentation, isolation and physico-chemical properties.
Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleophoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.
Kanasaki
Ryuichi
R
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
Sakamoto
Kazutoshi
K
Hashimoto
Michizane
M
Takase
Shigehiro
S
Tsurumi
Yasuhisa
Y
Fujie
Akihiko
A
Hino
Motohiro
M
Hashimoto
Seiji
S
Hori
Yasuhiro
Y
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D005658:Fungi / Q000145:classification* / Q000378:metabolism; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*
D000935:Antifungal Agents; C511074:FR 209602; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic