Facile regio- and stereoselective carbon-carbon coupling of phenol derivatives with aryl aziridines.
A chemo-, regio-, and stereoselective direct carbon-carbon coupling of readily available aryl borates with N-protected aryl aziridines provides a method for the synthesis of new 2-(o-hydroxyaryl)-2-aryl ethylamines which can be used, in a novel annulation sequence, to give stereodefined substituted 3-aryl indolines. [reaction: see text]
Pineschi
Mauro
M
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. pineschi@farm.unipi.it
Bertolini
Ferruccio
F
Crotti
Paolo
P
Macchia
Franco
F