title: Kinetic and mechanistic investigations of progesterone reaction with ozone.
abstract: The removal of progesterone by ozone in aqueous solution was studied in this work. The absolute rate constant was evaluated and first by-products were identified. The reaction was studied in the 2.0-8.0 pH range and was found to be a second-order reaction, first-order relative to each compound concentration. The rate constant, determined by kinetic experiments in presence of an OH radical scavenger (tert-butanol), was independent of pH. The value was evaluated to be equal to 480+/-30 M(-1)s(-1) by two kinetic methods. Mass spectrometry analyses were performed to investigate primary degradation products generated by the reaction of ozone with progesterone. Two by-products were evidenced. According to these results, a degradation pathway of progesterone reacting with ozone was proposed.
authors.affiliation: Laboratoire de Chimie de l'Eau et de l'Environnement, Ecole Superieure d'Ingenieurs de Poitiers, 40 avenue du Recteur Pineau, 86 022 Poitiers, Cedex, France. emmanuelle.barron@etu.univ-poitiers.fr
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Barron
authors.forename: Marie
authors.initials: M
authors.lastname: Deborde
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rabouan
authors.forename: Patrick
authors.initials: P
authors.lastname: Mazellier
authors.forename: Bernard
authors.initials: B
authors.lastname: Legube
mesh_terms: D004781:Environmental Exposure; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013058:Mass Spectrometry; D010126:Ozone / Q000737:chemistry*; D011374:Progesterone / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D011374:Progesterone; D010126:Ozone