Molecular pathogenetics of renal cancer.
Recent developments in genetics and molecular biology have led to an increased understanding of the pathobiology of renal cancer. Thorough knowledge of the molecular pathways associated with renal cancer is a prerequisite for novel potential therapeutic interventions. Studies are ongoing to evaluate novel anticancer agents that target specific molecular entities. This article reviews current knowledge on the genetics and molecular pathogenesis of sporadic and inherited forms of renal cancer.
Skolarikos
Andreas A
AA
Athens Medical School, 2nd Department of Urology, Sismanoglio Hospital, Athens, Greece. andskol@yahoo.com
Papatsoris
Athanasios G
AG
Alivizatos
Gerasimos
G
Deliveliotis
Charalambos
C
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D008967:Molecular Biology / Q000639:trends; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins