[Liver apoptosis].
Apoptosis or programmed cell death occurs in the liver as in other organs. In the normal state it is not a frequent mode of hepatic cell destruction. Morphological and biochemical characteristics of liver cell apoptosis do not differ from what is observed in other cells. The Fas receptor pathway, a frequent hepatic apoptotic pathway among various others, involves intra-cellular signals amplified by mitochondria. Although hepatic apoptosis may occur by following several others pathways, Fas, which is abundantly expressed in the plasma membrane of hepatocytes, is very often involved in hepatocyte demise during B or C viral hepatitis irrespective of their clinical form, alcoholic hepatitis, cholestasis due to accumulation of hepatic biliary salts, or certain types of drug-induced hepatitis. Fas is also probably responsible for the death of biliary cells in primary biliary cirrhosis. In contrast one of the causes of resistance to apoptosis of hepatic cancerous cells could be related to an alteration of the Fas receptor. This is why much experimental work is presently performed to achieve inhibition of the Fas receptor either at the mRNA level or at the level of Fas-inductible proteolytic enzymes called caspases. One perspective is a specific treatment of apoptosis as an adjuvant treatment of liver diseases.
Feldmann
Gérard
G
INSERM U 773, Faculté de Médecine Xavier Bichat, Université Paris 7- Denis Diderot, Paris. feldmann@bichat.inserm.fr
D017209:Apoptosis; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000473:pathology*; D008107:Liver Diseases / Q000503:physiopathology* / Q000628:therapy; D015398:Signal Transduction; D019014:fas Receptor / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D019014:fas Receptor