title: Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects.
abstract: Microbial transformation studies of the marine diterpene cyanthiwigin B (1), isolated from the Jamaican sponge Myrmekioderma styx, were accomplished. Two actinomycete cultures, Streptomyces NRRL 5690 and Streptomyces spheroides, significantly metabolized cyanthiwigin B to new metabolites. Streptomyces NRRL 5690 transformed cyanthiwigin B to three new compounds, cyanthiwigins AE (2), AF (3), and AG (4), and the known cyanthiwigin R (5). S. spheroides transformed cyanthiwigin B to cyanthiwigins S (6), E (7), and AE (2). All microbial-metabolized derivatives (2-7) of cyanthiwigin B exhibited the ability to increase the antimicrobial activity of curcuphenol, the major antimicrobial sesquiterpene isolated from M. styx.
authors.affiliation: Department of Pharmacognosy and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi 38677, USA.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Peng
authors.forename: Noer
authors.initials: N
authors.lastname: Kasanah
authors.forename: Charles E
authors.initials: CE
authors.lastname: Stanley
authors.forename: Jennifer
authors.initials: J
authors.lastname: Chadwick
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D007563:Jamaica; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D012717:Sesquiterpenes; C511567:cyanthiwigin B; C054389:curcuphenol