Effects of dexamethasone and chlorpromazine treatment on X-Y dissociation and multinucleated giant cell formation in hyperthermic mice.
The effects of anti-stress drugs on X-Y dissociation and multinucleated giant cell formation in the testes of hyperthermic mice were determined for the possible use of such drugs in animal production. Mice were injected with dexamethasone 1 mg/kg or 2 mg/kg, chlorpromazine 1 mg/kg or 4 mg/kg, or 0.85% saline, and heat stressed for 4 d at 35 +/- 1 C and 65 +/- 1 % relative humidity. Mice were killed 5 d after stress, and the testes processed for observation of meiotic chromosomes and testicular histology. Heat stress caused a significant increase in X-Y bivalent dissociation in diakinesis-metaphase I spermatocytes and a significant increase in formation of multinucleated giant cells. Drug treatment increased X-Y dissociation but had no significant effect on giant cell formation.
Waldbieser
G C
GC
Cytogenetics Laboratory Dept. of Animal Sciences Purdue University West Lafayette, IN 47907 USA.
Chrisman
C L
CL