title: Effects of vitamins A and D on the biosynthesis of L-ascorbic acid by rat-liver microsomes.
abstract: 1. The synthesis of l-ascorbic acid from either d-glucuronolactone or l-gulonolactone by liver microsomes of rats is decreased under conditions of hypervitaminosis A; under hypervitaminosis D the synthesis from d-glucuronolactone is increased and that from l-gulonolactone is not affected. 2. The microsomal conversion of l-gulonolactone into l-ascorbic acid is impaired in liver tissues of rats made deficient with respect to either vitamin A or vitamin D when compared with the controls maintained on stock diet.
authors.affiliation: Department of Applied Chemistry and Biochemistry, University Colleges of Science and Technology, Calcutta 9, India.
authors.forename: N C
authors.initials: NC
authors.lastname: Ghosh
authors.forename: I
authors.initials: I
authors.lastname: Chatterjee
authors.forename: G C
authors.initials: GC
authors.lastname: Chatterjee