[Advances in molecular biology of extended-spectrum beta-lactamase].
Extended-spectrum beta-lactamases (ESBLs), mediated by plasmids, can hydrolyze and cause resistance to penicillins, broad spectrum-cephalosporins, and monobactams. Most ESBLs are derived from the widespread broad-spectrum beta-lactamases TEM-1 and SHV-1. There are also other families of ESBLs, including CTX-M and OXA-type enzymes as well as novel unrelated beta-lactamases. This article reviews recent advances in the classification, characteristics, and other molecular biological aspects of ESBLs.
Xiang
Qian
Q
Department of Pharmacology and Toxicology, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China.
You
Xue-fu
XF
Jiang
Jian-dong
JD
D008967:Molecular Biology; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics
D001618:beta-Lactamases