Achiral benzophenone ligand-rhodium complex with chiral diamine activator for high enantiocontrol in asymmetric transfer hydrogenation.
The chirality of an achiral benzophenone-based rhodium complex can be controlled by chiral diamines to afford significantly high enantioselectivity in the catalytic asymmetric transfer hydrogenation of ketones (up to 99% ee, 99% yield).
Mikami
Koichi
K
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, 152-8552, Japan. kmikami@o.cc.titech.ac.jp
Wakabayashi
Kazuki
K
Yusa
Yukinori
Y
Aikawa
Kohsuke
K
D001577:Benzophenones / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry*; D006865:Hydrogenation; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D001577:Benzophenones; D003959:Diamines; D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; C047723:benzophenone; D012238:Rhodium