[Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population].
OBJECTIVE
This case-control study was designed to detect the association between STK15 Phe31Ile polymorphism and colorectal cancer.


METHODS
Genotypes were determined in 283 patients with colorectal cancer and 283 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.


RESULTS
The frequency of the STK15 Ile/Ile genotype was significantly higher in cancer cases than in controls (50.2% vs. 36.8%; P = 0.02). Subjects with the Ile/Ile genotype had an increased risk for the occurrence of colorectal cancer compared with those with the STK15 Phe/Phe genotype (adjusted OR, 1.92; 95% CI, 1.13 - 3.27). No significant association was observed between this STK15 polymorphism and risk of metastasis of the cancer.


CONCLUSIONS
These findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.
Zhang
Wen-jie
WJ
Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Miao
Xiao-ping
XP
Sun
Tong
T
Zhang
Xue-mei
XM
Qu
Shi-ning
SN
Tan
Wen
W
Xiong
Ping
P
Zheng
Rong
R
Lin
Dong-xin
DX
D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D064096:Aurora Kinase A; D064127:Aurora Kinases; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D012004:Rectal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases