Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.
Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.
Olsen
Anders
A
Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Vantipalli
Maithili C
MC
Lithgow
Gordon J
GJ
D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology; D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002470:Cell Survival; D000071877:Checkpoint Kinase 1; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D011494:Protein Kinases / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D000071877:Checkpoint Kinase 1; D006360:Heat-Shock Proteins; D011494:Protein Kinases; D029702:Schizosaccharomyces pombe Proteins; C511096:CID-1 protein, C elegans; C511095:CID-1 proterin, S pombe