Alkaloids and chemical diversity of Stemona tuberosa.
Phytochemical investigation of the chemical components of Stemona tuberosa led to the isolation of two new alkaloids named tuberostemonine K (1) and tuberospironine (2), together with the known tuberostemonine (3). The new structures of 1 and 2 were elucidated through extensive spectroscopic analyses, while the molecular structure of 3 was confirmed by X-ray analysis. A gradient reversed-phase HPLC-ELSD method was established for the investigation of the chemical diversity of S. tuberosa from 13 localities, and four types of chemical variation featured by the major components 3, neotuberostemonine (4), croomine (5), and stemoninine (6), respectively, were observed.
Jiang
Ren-Wang
RW
Institute of Chinese Medicine, Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China.
Hon
Po-Ming
PM
Zhou
Yan
Y
Chan
Yiu-Man
YM
Xu
Yan-Tong
YT
Xu
Hong-Xi
HX
Greger
Harald
H
Shaw
Pang-Chui
PC
But
Paul Pui-Hay
PP
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D041901:Stemonaceae / Q000737:chemistry*
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D013141:Spiro Compounds; C511569:tuberospironine; C034243:tuberostemonine