title: [Advances in molecular biology of extended-spectrum beta-lactamase].
abstract: Extended-spectrum beta-lactamases (ESBLs), mediated by plasmids, can hydrolyze and cause resistance to penicillins, broad spectrum-cephalosporins, and monobactams. Most ESBLs are derived from the widespread broad-spectrum beta-lactamases TEM-1 and SHV-1. There are also other families of ESBLs, including CTX-M and OXA-type enzymes as well as novel unrelated beta-lactamases. This article reviews recent advances in the classification, characteristics, and other molecular biological aspects of ESBLs.
authors.affiliation: Department of Pharmacology and Toxicology, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiang
authors.forename: Xue-fu
authors.initials: XF
authors.lastname: You
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Jiang
mesh_terms: D008967:Molecular Biology; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics
chemical_list: D001618:beta-Lactamases