title: Predictors of clinical outcome in children undergoing orthotopic liver transplantation for acute and chronic liver disease.
abstract: The current United Network for Organ Sharing (UNOS) policy is to allocate liver grafts to pediatric patients with chronic liver disease based on the pediatric end-stage liver disease (PELD) scoring system, while children with fulminant hepatic failure may be urgently listed as Status 1a. The objective of this study was to identify pre-transplant variables that influence patient and graft survival in those children undergoing LTx (liver transplantion) for FHF (fulminant hepatic failure) compared to those patients transplanted for extrahepatic biliary atresia (EHBA), a chronic form of liver disease. The UNOS Liver Transplant Registry was examined for pediatric liver transplants performed for FHF and EHBA from 1987 to 2002. Variables that influenced patient and graft survival were assessed using univariate and multivariate analysis. Kaplan-Meier analysis of FHF and EHBA groups revealed that 5 year patient and graft survival were both significantly worse (P < 0.0001) in those patients who underwent transplantation for FHF. Multivariate analysis of 29 variables subsequently revealed distinct sets of factors that influenced patient and graft survival for both FHF and EHBA. These results confirm that separate prioritizing systems for LTx are needed for children with chronic liver disease and FHF; additionally, our findings illustrate that there are unique sets of variables which predict survival following LTx for these two groups.
authors.affiliation: Department of Pediatrics, Division of Gastroenterology, Mattel Children's Hospital at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Rhee
authors.forename: Kiran
authors.initials: K
authors.lastname: Narsinh
authors.forename: Robert S
authors.initials: RS
authors.lastname: Venick
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Molina
authors.forename: Visal
authors.initials: V
authors.lastname: Nga
authors.forename: Rita
authors.initials: R
authors.lastname: Engelhardt
authors.forename: Martín G
authors.initials: MG
authors.lastname: Martín
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis*; D016031:Liver Transplantation; D011379:Prognosis; D012189:Retrospective Studies