title: Elevation in compartment pressure following hypovolemic shock and fluid resuscitation: a canine model.
abstract: We induced hemorrhagic shock in seven dogs and then resuscitated them with intravenous (IV) lactated ringers. We then monitored anterior leg compartment pressures via a slit catheter during both bleeding and reperfusion. These values were compared with controls that received IV fluids without being bled. Compartment pressures in resuscitated dogs rose well above control values. These values were statistically significant when compared to controls via the paired student t test (P < .01). This model demonstrates that sufficient swelling occurs to significantly elevate compartment pressures, even in the absence of local trauma. While this elevation may not be sufficient enough to cause a compartment syndrome, it reinforces the notion that extremities that have experienced ischemia and reperfusion are at an increased risk for developing compartment syndrome.
authors.affiliation: Department of Orthopedics and Rehabilitation, University of Wisconsin Medical School, Madison, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Ablove
authors.forename: George
authors.initials: G
authors.lastname: Babikian
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Moy
authors.forename: Philip M
authors.initials: PM
authors.lastname: Stegemann
mesh_terms: D000818:Animals; D003161:Compartment Syndromes / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D005440:Fluid Therapy / Q000379:methods; D006614:Hindlimb / Q000098:blood supply* / Q000503:physiopathology*; D007552:Isotonic Solutions / Q000627:therapeutic use*; D011312:Pressure; D000077325:Ringer's Lactate; D012769:Shock / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate