title: Predominance of younger age, advanced stage, poorly-differentiated and mucinous histology in Israeli Arab patients with colorectal cancer.
abstract: BACKGROUND
  Colorectal cancer (CRC) incidence in the Israeli population is higher in the Jewish population than among Arabs.
  
  
  METHODS
  To determine the differences in demographic, clinical, histopathological and molecular characteristics of CRC between these two ethnic groups, 125 Arab patients treated at 3 community hospitals over a 20-year period were compared to a group of 208 consecutive Jewish patients. The mutator (replication error-positive [RER]) phenotype was detected by immunohistochemical evaluation of hMLH1 and hMSH2 protein expression in tumor tissue.
  
  
  RESULTS
  The Arab patients were younger than the Jewish patients with a higher percentage of poorly-differentiated and mucinous cancers and a higher percentage of advanced stage cancers (Dukes' C+D) at presentation. The mutator phenotype was detected at similar rates in both ethnic groups.
  
  
  CONCLUSIONS
  Our study demonstrated that CRC patients from two major ethnic populations in Israel, Arabs and Jews, differed in terms of the prevalence of the disease, pathological features and age at presentation, but not in frequency of mismatch-repair-positive cancers.
authors.affiliation: Department of Surgery, Meir General Hospital, Sapir Medical Center, Kfar Sava, Israel. shpitzca@post.tau.ac.Il
authors.forename: Baruch
authors.initials: B
authors.lastname: Shpitz
authors.forename: Maya
authors.initials: M
authors.lastname: Millman
authors.forename: Yehiel
authors.initials: Y
authors.lastname: Ziv
authors.forename: Ehud
authors.initials: E
authors.lastname: Klein
authors.forename: Milla
authors.initials: M
authors.lastname: Grankin
authors.forename: Semion
authors.initials: S
authors.lastname: Gochberg
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
authors.forename: Arie
authors.initials: A
authors.lastname: Halevi
authors.forename: Joelle
authors.initials: J
authors.lastname: Bernheim
authors.forename: Yakov
authors.initials: Y
authors.lastname: Khromov
authors.forename: Mordechay
authors.initials: M
authors.lastname: Gutman
authors.forename: Joel
authors.initials: J
authors.lastname: Sayfan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D000367:Age Factors; D000368:Aged; D018912:Arabs / Q000208:ethnology; D002352:Carrier Proteins / Q000096:biosynthesis; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D000070956:MutL Proteins; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000096:biosynthesis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C088996:PMS1 protein, human; D000070957:MutL Protein Homolog 1; D000070956:MutL Proteins