title: Shape deformation of the insula in schizophrenia.
abstract: Schizophrenia has been conceptualized to be a neurodevelopmental disorder. Neuroimaging evidence was generally findings of volumetric reductions in various brain structures. The shape analysis of the insula can uncover unique structural deformity in the neurodevelopmental disorder, which cannot be revealed from a simple volume measurement. The objective of this study was to demonstrate a subtle change of the insula in schizophrenia using our special shape analysis technique. Subjects were 23 patients with schizophrenia and 23 normal healthy subjects. A landmark-based structural and surface shape analysis of the insula was performed using high-spatial resolution magnetic resonance imaging. A characteristic finding was that the frontotemporal sides of the right insula were deformed in the patients with schizophrenia compared with normal controls. This deformation can be associated with abnormal development of the frontal and temporal lobes in schizophrenia.
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Dong-Pyo
authors.initials: DP
authors.lastname: Jang
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Tae-Sub
authors.initials: TS
authors.lastname: Chung
authors.forename: Suk Kyoon
authors.initials: SK
authors.lastname: An
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Jung
authors.forename: Jun-Kee
authors.initials: JK
authors.lastname: Lee
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology; D012016:Reference Values; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology