Classification of antipsychotic drugs by gene expression in the frontal cortex of mice.
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorpromazine and thioridazine were selected as typical antipsychotics, and olanzapine and quetiapine as atypical antipsychotics. Since these drugs have similar chemical structures, the effect of the basic structure on gene expression can be eliminated. Cluster analysis of microarray experiments separated 4-drug-administered mice into chlorpromazine-quetiapine and thioridazine-olanzapine groups. This classification scheme is different from that which is based on criteria currently used to group the typical and atypical drugs and suggests that antipsychotic drugs can be further separated into multiple groups.
Iwata
Shin-ichi
S
Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima 890-8520, Japan. shinichi@m.kufm.kagoshima-u.ac.jp
Morioka
Hirofumi
H
Miyata
Atsuro
A
D000818:Animals; D014150:Antipsychotic Agents / Q000145:classification*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology; D016000:Cluster Analysis; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000494:pharmacology; D005625:Frontal Lobe / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects*; D008297:Male; D051379:Mice; D000077152:Olanzapine; D000069348:Quetiapine Fumarate; D013881:Thioridazine / Q000008:administration & dosage / Q000494:pharmacology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D013881:Thioridazine; D000077152:Olanzapine; D002746:Chlorpromazine