title: Homodyne en face optical coherence tomography.
abstract: We demonstrate, for what we believe to be the first time, the use of a 3 x 3 fiber-optic coupler to realize a homodyne optical coherence tomography (OCT) system for en face imaging of highly scattering tissues and turbid media. The homodyne OCT setup exploits the inherent phase shifts between different output ports of a 3 x 3 fiber-optic coupler to extract amplitude information of a sample. Our homodyne en face OCT system features a measured resolution of 14 microm axially and 9.4 microm laterally with a 90 dB signal-to-noise ratio at 10 micros integration time. En face OCT imaging of a stage 52 Xenopus laevis was successfully demonstrated at a depth of 600 microm within the sample.
authors.affiliation: Department of Electrical Engineering, MC 136-93, California Institute of Technology, Pasadena, 91125, USA. zyaqoob@caltech.edu
authors.forename: Zahid
authors.initials: Z
authors.lastname: Yaqoob
authors.forename: Jeff
authors.initials: J
authors.lastname: Fingler
authors.forename: Xin
authors.initials: X
authors.lastname: Heng
authors.forename: Changhuei
authors.initials: C
authors.lastname: Yang
mesh_terms: D019412:Anatomy, Cross-Sectional / Q000295:instrumentation* / Q000379:methods; D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007368:Interferometry / Q000295:instrumentation* / Q000379:methods; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods; D055100:Optical Fibers; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D014982:Xenopus laevis / Q000033:anatomy & histology*