Improvement of the surface biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties.
To improve the surface biocompatibility of the silicone intraocular lens (IOL), 2-methacryloyloxyethyl phosphorylcholine (MPC) was tethered onto the IOL through air plasma treatment. Chemical changes on the IOL surface were characterized by X-ray photoelectron spectroscopy (XPS) to confirm the covalent binding of MPC. Morphologies of the IOL surfaces were observed by scanning electron microscopy (SEM) to optimize the plasma treatment process. The hydrophilicity and biocompatibility of the control and modified IOLs were compared by the measurements of water contact angle, platelet adhesion, macrophage cell culture, and lens epithelial cell (LEC) attachment. It was found that, after the tethering of MPC, the hydrophilicity of the IOL can be improved significantly and permanently, and the platelet, macrophage, and LEC adhesion on the IOL surface are obviously suppressed, which indicated the enhancement of surface biocompatibility.
Yao
Ke
K
Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, People's Republic of China. xlren@zju.edu.cn
Huang
Xiao-Dan
XD
Huang
Xiao-Jun
XJ
Xu
Zhi-Kang
ZK
D001672:Biocompatible Materials; D001792:Blood Platelets / Q000166:cytology; D002448:Cell Adhesion; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology; D007910:Lenses, Intraocular; D008264:Macrophages / Q000166:cytology; D013499:Surface Properties
D001672:Biocompatible Materials