title: Refinement of quantitative trait loci on bovine chromosome 18 affecting health and reproduction in US Holsteins.
abstract: Selection for increased milk yield is associated with decreased fertility in US Holsteins. Previously, a putative quantitative trait locus (QTL) on chromosome 18 affecting daughter pregnancy rate (DPR) was identified in one family. Our aim was to determine the validity of the QTL using additional markers and an extended pedigree. Twelve markers were genotyped in 940 descendants of the original sire in which the QTL was identified. Analysis of the extended pedigree detected significant and suggestive QTL for DPR, productive life and somatic cell score. Further analysis is underway to refine the QTL region so that positional candidate genes can be identified.
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Muncie
authors.forename: J P
authors.initials: JP
authors.lastname: Cassady
authors.forename: M S
authors.initials: MS
authors.lastname: Ashwell
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D033481:Chromosomes, Mammalian; D005260:Female; D005298:Fertility / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D018873:Pregnancy Rate; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers