title: An overview of the serpin superfamily.
abstract: Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne VIC 3800, Australia.
authors.forename: Ruby H P
authors.initials: RH
authors.lastname: Law
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Zhang
authors.forename: Sheena
authors.initials: S
authors.lastname: McGowan
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Buckle
authors.forename: Gary A
authors.initials: GA
authors.lastname: Silverman
authors.forename: Wilson
authors.initials: W
authors.lastname: Wong
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Rosado
authors.forename: Chris G
authors.initials: CG
authors.lastname: Langendorf
authors.forename: Rob N
authors.initials: RN
authors.lastname: Pike
authors.forename: Philip I
authors.initials: PI
authors.lastname: Bird
authors.forename: James C
authors.initials: JC
authors.lastname: Whisstock
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D011487:Protein Conformation; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000145:classification / Q000502:physiology*; D015843:Serpins / Q000737:chemistry* / Q000145:classification / Q000502:physiology*
chemical_list: D015842:Serine Proteinase Inhibitors; D015843:Serpins