Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study.
To localize quantitative trait loci for insulin metabolism and obesity, genome scans/linkage analyses were performed on >900 members of 32 extended families participating in phase 3 of the Strong Heart Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota. Linkage analyses of fasting insulin and two obesity-related phenotypes, BMI and percent fat mass, were performed independently in each of the three populations. For log fasting insulin, we found a genome-wide maximum, robust logarithm of odds (LOD) score of 3.42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas.
Diego
Vincent P
VP
Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245-0549, USA. vdiego@darwin.sfbr.org
Göring
Harald H H
HH
Cole
Shelley A
SA
Almasy
Laura
L
Dyer
Thomas D
TD
Blangero
John
J
Duggirala
Ravindranath
R
Laston
Sandra
S
Wenger
Charlotte
C
Cantu
Teresa
T
Dyke
Bennett
B
North
Kari
K
Schurr
Theodore
T
Best
Lyle G
LG
Devereux
Richard B
RB
Fabsitz
Richard R
RR
Howard
Barbara V
BV
MacCluer
Jean W
JW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona; D015992:Body Mass Index; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005215:Fasting / Q000097:blood; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood*; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics*; D009825:Oklahoma; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics; D013023:South Dakota
D007328:Insulin