Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.
We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.
Clapcote
Steven J
SJ
Mount Sinai Hospital Research Institute, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. clapcote@mshri.on.ca
Roder
John C
JC
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D013045:Species Specificity; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
C498794:Disc1 protein, mouse; D009419:Nerve Tissue Proteins