title: Effects of soybean agglutinin on body composition and organ weights in rats.
abstract: An experiment was conducted to assess the effect of soybean agglutinin dosage level on growth, body composition, plasma lipids, glucose, urea nitrogen content and aminotransferase activities in rats. Male and female rats (n=60) weaned at 19 d were given a dose of 0, 3.5, 7.0, 10.5, or 14.0 mg soybean agglutinin by gastric infusion once daily for 10 days. With increasing doses of soybean agglutinin, body weight, lipid content of carcass, spleen and kidneys relative dry weights decreased, while small intestine and pancreatic weight, the contents of urea nitrogen and triglyceride, and the activities of aspartate aminotransferase linearly increased in plasma. Though soybean agglutinin decreased plasma insulin content, changes in plasma glucose content due to soybean agglutinin were not detected. It is suggested that dietary soybean agglutinin may affect the secretion of other hormones besides insulin, which modulate blood glucose reserves. In conclusion, consumption of soybean agglutinin resulted in a depletion of lipid and an overgrowth of small intestine and pancreas in rats. Meanwhile, poor growth of spleen and kidneys was observed in the soybean agglutinin-fed rats.
authors.affiliation: National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zang
authors.forename: Defa
authors.initials: D
authors.lastname: Li
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Piao
authors.forename: Shusheng
authors.initials: S
authors.lastname: Tang
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D001823:Body Composition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000254:growth & development; D008055:Lipids / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects*; D037121:Plant Lectins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D030262:Soybean Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*; D000637:Transaminases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D037121:Plant Lectins; D030262:Soybean Proteins; D000637:Transaminases