Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence?
A preterm male infant with a patent ductus arteriosus developed neutropenia during treatment with indomethacin. Afterward, the mother described her own history of indomethacin-associated neutropenia. During the recovery from the neutropenia, the infant became septic with bacteremia caused by Enterobacter cloacae. Although indomethacin-related neutropenia has been described in adults, no case in a neonate has been reported. If neutropenia occurs after indomethacin therapy in a neonate, a familial history of indomethacin-associated neutropenia should be sought and the increased risk of infection should be considered.
Bengtsson
B-O S
BO
Division of Neonatology, Department of Pediatrics, University of California, Davis, CA, USA.
Milstein
J M
JM
Sherman
M P
MP
D002317:Cardiovascular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D016972:Enterobacter cloacae; D004756:Enterobacteriaceae Infections / Q000209:etiology*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications; D018805:Sepsis / Q000209:etiology*
D002317:Cardiovascular Agents; D007213:Indomethacin