[Synergistic action of some antibacterial agents in studies on albino mice with experimental plague caused by Fr- phenotype strain of the plague microbe].
Possible use of ciprofloxacin combinations with some other antibiotics such as rifampicin, ampicillin, cefotaxime, doxycycline and amikacin was studied on albino mice with experimental plague caused by the pathogen strain (approximately 1000 LD50) deprived of the ability to produce the capsular antigen, fraction I (Fra- phenotype). The combination of ciprofloxacin with ampicillin or doxycycline had no effect on the increase of the survival rate (t<2) evident of inexpediency of its use in the infection caused by the Fra- strains of the plague microbe. The combination of ciprofloxacin and cefotaxime used in definite doses had some effect (t=2.6). The most significant synergistic effect was observed with the use of ciprofloxacin in combination with amikacin or rifampicin (t>3.3-9.0) which made the combination most promising.
Shcherbaniuk
A I
AI
Liukshina
E Iu
EIu
Ryzhko
I V
IV
Smorodinova
Iu V
IuV
D000583:Amikacin / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D008815:Mice, Inbred Strains; D010930:Plague / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use*; D015010:Yersinia pestis
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D000583:Amikacin; D012293:Rifampin