title: The relationship between mitochondrial shape and function and the cytoskeleton.
abstract: Mitochondria are crucial organelles for life and death of the cell. They are prominent players in energy conversion and integrated signaling pathways including regulation of Ca2+ signals and apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport at specialized cellular sites. This transport occurs by interactions with a variety of cytoskeletal proteins that also have the ability to influence shape and function of the organelle. A growing body of evidence suggests that mitochondria use cytoskeletal proteins as tracks for their movement; in turn, mitochondrial morphology and function is regulated via mostly uncharacterized pathways, by the cytoskeleton.
authors.affiliation: Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, I-35129, Padova, Italy.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Anesti
authors.forename: Luca
authors.initials: L
authors.lastname: Scorrano
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D000199:Actins / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008870:Microtubules / Q000502:physiology / Q000648:ultrastructure; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000502:physiology; D015003:Yeasts / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D000199:Actins