Acanthocheilonema viteae in Mastomys coucha: chemotherapeutic and chemoprophylactic role of vitamin A in experimental filarial infection.
The role of vitamin A was evaluated for its chemotherapeutic and chemoprophylactic action against Acanthocheilonema viteae infection in Mastomys coucha. Vitamin A was administered for 10 days, five days before infection and five days post infection. On day 0 experimental animals as well as controls were infected with L3, the infective stage. Establishment of the worms revealed significantly less percentage of worm recovery over untreated controls. Cell-mediated response was found to be the cause of this reduction in worm recovery, whereas humoral response was not significant as IgG, IgA and IgM titres were low.
Bhatnagar
Sunita
S
Regional Plant Resource Centre, Nayapalli, Bhubaneswar, India. sunita_bhatnagar@hotmail.com
Bhattacharya
Shailja
S
Chatterjee
R K
RK
D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification*; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D005368:Filariasis / Q000517:prevention & control*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008366:Mansonella / Q000302:isolation & purification / Q000502:physiology*; D051189:Murinae / Q000469:parasitology*; D014599:Uterus; D014801:Vitamin A / Q000627:therapeutic use*
D000871:Anthelmintics; D014801:Vitamin A