title: Factors associated with malaria treatment failures in Ibadan.
abstract: This study aims to find out factors associated with anti-malarial drug resistance in some selected areas in Ibadan. One thousand one hundred and two subjects were interviewed using a semi structured questionnaire. Respondents were put into two groups (high and low resistant areas). The Results revealed a high level of drug use for treating malaria particularly choloroquine and sulfadoxine-pyrimethamine ("Fansidar"). The Results also showed that the two groups were not significantly different with respect to clearance of infection, but there was a significant difference between clearance of infection and whether or not the respondent completed the course of treatment in each group (P<0.05). When both groups were combined, the Mantel-Haenszel test showed that the response difference between the two groups was significant. (OR = 3.44 (CI = 1.8 to 6.51)) i.e those that completed the treatment were 3 times more likely to have their infection cleared than those that did not complete the treatment. A significant finding was that non-compliance with treatment was a major factor associated with treatment failure The prevalence of drug resistance was a little higher in the high resistant group compared to the low resistant group; but this difference was not statistically significant. These results underscore the need for adequate health education about the treatment of malaria and the importance of compliance in this community.
authors.affiliation: Department of Epidemiology, Medical Statistics and Environmental Health, Institute of Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O B
authors.initials: OB
authors.lastname: Yusuf
authors.forename: O
authors.initials: O
authors.lastname: Oladepo
authors.forename: S O
authors.initials: SO
authors.lastname: Odunbaku
authors.forename: O
authors.initials: O
authors.lastname: Alaba
authors.forename: O S
authors.initials: OS
authors.lastname: Osowole
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D015438:Health Behavior; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007407:Interviews as Topic; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010349:Patient Compliance; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D002738:Chloroquine