Representation of head-centric flow in the human motion complex.
Recent neuroimaging studies have identified putative homologs of macaque middle temporal area (area MT) and medial superior temporal area (area MST) in humans. Little is known about the integration of visual and nonvisual signals in human motion areas compared with monkeys. Through extra-retinal signals, the brain can factor out the components of visual flow on the retina that are induced by eye-in-head and head-in-space rotations and achieve a representation of flow relative to the head (head-centric flow) or body (body-centric flow). Here, we used functional magnetic resonance imaging to test whether extra-retinal eye-movement signals modulate responses to visual flow in the human MT+ complex. We distinguished between MT and MST and tested whether subdivisions of these areas may transform the retinal flow into head-centric flow. We report that interactions between eye-movement signals and visual flow are not evenly distributed across MT+. Pursuit hardly influenced the response of MT to flow, whereas the responses in MST to the same retinal stimuli were stronger during pursuit than during fixation. We also identified two subregions in which the flow-related responses were boosted significantly by pursuit, one overlapping part of MST. In addition, we found evidence of a metric relation between rotational flow relative to the head and fMRI signals in a subregion of MST. The latter findings provide an important advance over published single-cell recordings in monkey MST. A visual representation of the rotation of the head in the world derived from head-centric flow may supplement semicircular canals signals and is appropriate for cross-calibrating vestibular and visual signals.
Goossens
Jeroen
J
Department of Biophysics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. j.goossens@science.ru.nl
Dukelow
Sean P
SP
Menon
Ravi S
RS
Vilis
Tutis
T
van den Berg
Albert V
AV
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*