[Relationship of ectodysplasin gene signaling with development and regeneration of sweat glands].
OBJECTIVE
To investigate the expression of ectodysplasin (EDA) gene signaling and its relationship with the development and regeneration of sweat glands.


METHODS
The articles concerned in the latest years were extensively reviewed.


RESULTS
EDA gene is an important signaling pathway associated with the developmental procedure of sweat glands in early fetal stage. Abnormality or depletion of function in sweat glands partially owed to the defect of EDA gene.


CONCLUSIONS
EDA signaling has its biological significance in inducing development and morphogenesis of sweat glands and in maintaining physiological function of skin. It could be a new approach to repair or regenerate the sweat glands for clinical therapy by regulating the expression of EDA gene.
Zhou
Gang
G
Key Research Laboratory of the Wound Repair, the 304th Clinical Department, General Hospital of PLA, Beijing, 100037, P.R. China.
Li
Haihong
H
Fu
Xiaobing
X
D053331:Ectodysplasins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D015398:Signal Transduction / Q000235:genetics*; D013545:Sweat Glands / Q000254:growth & development / Q000502:physiology*
C506018:EDA protein, human; D053331:Ectodysplasins