title: Checkpoint activation: don't get mad too much.
abstract: The Mad2 protein is required to delay sister chromatid separation until all chromosomes have been aligned on the mitotic spindle. Two recent studies provide new insights into how Mad2 contributes to this remarkable task.
authors.affiliation: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. lenart@imp.univie.ac.at
authors.forename: Péter
authors.initials: P
authors.lastname: Lénárt
authors.forename: Jan-Michael
authors.initials: JM
authors.lastname: Peters
mesh_terms: D002135:Calcium-Binding Proteins / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002842:Chromatids / Q000378:metabolism; D018816:Genes, cdc; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D064246:Mad2 Proteins; D012097:Repressor Proteins / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D012097:Repressor Proteins