title: Altered nociceptive response in ADAM11-deficient mice.
abstract: Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
authors.affiliation: Tsukuba Research Laboratory, Eisai Co. Ltd., 5-1-3, Tokodai, Tsukuba, Ibaraki, 300-2635, Japan. e2-takahashi@hhc.eisai.co.jp
authors.forename: Eiki
authors.initials: E
authors.lastname: Takahashi
authors.forename: Koji
authors.initials: K
authors.lastname: Sagane
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasu
authors.forename: Junro
authors.initials: J
authors.lastname: Kuromitsu
mesh_terms: D051722:ADAM Proteins / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D000818:Animals; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010146:Pain / Q000235:genetics* / Q000378:metabolism*; D010147:Pain Measurement / Q000379:methods*
chemical_list: D008565:Membrane Proteins; C107204:ADAM 11 protein, mouse; D051722:ADAM Proteins