Anti-RNA virus activity of polyoxometalates.
The anti-RNA virus activity of polyoxometalates (POM) is reviewed, with a special emphasis on the anti-respiratory virus activities. There are many causative agents of acute viral respiratory infections; and it is rather difficult to identify the relevant agent in a given case by rapid clinical means. During acute progress of infection before the definitive diagnosis is obtained physicians need to prescribe certain broad spectrum anti-viral drugs. A titanium containing polyoxotungstate, PM-523 exhibited potent anti-influenza virus (FluV) A and anti-respiratory syncytial virus (RSV) activities in vitro. Therapeutic effect of FluV A infected mice with aerosol inhalation of PM-523 was proven. A vanadium substituted polyoxotungstate, PM-1001 has antiviral activity against FluV A, RSV, parainfluenza virus (PfluV) type 2, Dengue fiver virus, HIV-1 and SARS coronavirus in vitro. Thus, POMs have been proven to be broad spectrum and non-toxic anti-RNA virus agents in both in vitro and in vivo experiments and are promising candidates for first-line therapeutics in acute respiratory diseases.
Shigeta
Shiro
S
Bureau of Prefectural Hospitals, Fukushima Prefecture, Japan. sshigeta@fmu.ac.jp
Mori
Shuichi
S
Yamase
Toshihiro
T
Yamamoto
Norio
N
Yamamoto
Naoki
N
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017934:Coronavirus / Q000187:drug effects; D024882:Drug Resistance, Viral; D004357:Drug Synergism; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D009975:Orthomyxoviridae / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D012254:Ribavirin / Q000494:pharmacology / Q000627:therapeutic use; D014025:Titanium / Q000627:therapeutic use; D017973:Tungsten Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D017968:Vanadium Compounds / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy; D000099294:Polyoxometalates
D000998:Antiviral Agents; D012254:Ribavirin; D014025:Titanium; D017973:Tungsten Compounds; D017968:Vanadium Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates