title: A new cytotoxic amide from the stem wood of Hibiscus tiliaceus.
abstract: A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N- trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of beta-sitosterol and stigmasterol, a mixture of beta-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, ROC.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Shi-Yu
authors.initials: SY
authors.lastname: Huang
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Tai-Chi
authors.initials: TC
authors.lastname: Wang
authors.forename: Hui-Yu
authors.initials: HY
authors.lastname: Fang
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D031584:Hibiscus / Q000737:chemistry*; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000178:Acrylamides; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D003603:Cytotoxins; D062385:Hydroxybenzoates; C515795:N-(4-hydroxy-3,5-dimethoxyphenethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide; D010936:Plant Extracts; D013256:Steroids; C515794:hibiscusin; D006139:Guaiacol