Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide.
Oxidation of a protected TyrValTrpTrp tetrapeptide results in direct formation of the indole bis-oxazole core of diazonamide A.
Sperry
Jonathan
J
Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK EX4 4QD.
Moody
Christopher J
CJ
D032701:Biomimetics; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D009842:Oligopeptides; D010080:Oxazoles; C408862:diazonamide A