title: Comprehensive two-dimensional liquid chromatography-time-of-flight mass spectrometry in the analysis of acidic compounds in atmospheric aerosols.
abstract: A novel method utilising comprehensive two-dimensional liquid chromatography interfaced to electrospray ionisation time-of-flight mass spectrometry was developed for the determination of organic acids in atmospheric aerosols. The system was applied to the analysis of methanolic extracts of filters from a high volume sampler. The enhanced separation power of two-dimensional separation was demonstrated in the analysis of both rural and urban samples. Quantification was performed for compounds for which standards were available. Limit of detection was 2-200 ng/ml. Average reproducibility of retention times in each dimensions was 0.1%, and average reproducibility of peak areas was 8% (10 microg/ml, n=3).
authors.affiliation: Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014, Helsinki, Finland.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Pól
authors.forename: Barbora
authors.initials: B
authors.lastname: Hohnová
authors.forename: Matti
authors.initials: M
authors.lastname: Jussila
authors.forename: Tuulia
authors.initials: T
authors.lastname: Hyötyläinen
mesh_terms: D000143:Acids / Q000032:analysis*; D000336:Aerosols / Q000032:analysis*; D001272:Atmosphere / Q000032:analysis*; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*
chemical_list: D000143:Acids; D000336:Aerosols