Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method.
In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox of SO(3)(2-) with Ce(IV) in acidic medium. Under the optimized conditions, the proposed method allows the measurement of metoprolol tartrate over the range of 1.5 x 10(-8) to 7.3 x 10(-6)mol/L with a detection limit of 4.7 x 10(-9)mol/L (3sigma), and the relative standard deviation for 7.3 x 10(-7)mol/L metoprolol tartrate (n=11) is 2.20%. The utility of this method was demonstrated by determining metoprolol tartrate in tablets and human urine sample.
Liu
Haiyan
H
Department of Chemistry, East China Normal University, Shanghai 200062, China.
Ren
Juanjuan
J
Hao
Yuhong
Y
Ding
Hongchun
H
He
Pingang
P
Fang
Yuzhi
Y
D002586:Cesium; D017022:Flow Injection Analysis / Q000379:methods*; D006801:Humans; D008163:Luminescent Measurements; D008790:Metoprolol / Q000032:analysis* / Q000652:urine; D013447:Sulfites; D013607:Tablets
D013447:Sulfites; D013607:Tablets; D002586:Cesium; C025407:cesium sulfate; D008790:Metoprolol; C025026:sodium sulfite