Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension.
BACKGROUND
Several studies suggested the role of the genes of the rennin-angiotensin system in the pathogenesis of essential arterial hypertension.


METHODS
We investigated 100 consecutive hypertensive patients (42 males and 58 females; mean +/- SD age, 55.14 +/- 9.49 years) for M235T and T174M polymorphisms. Seventy six normotensive patients (28 males and 48 females; mean +/- SD age, 54.94 +/- 9.56 years) formed the control group.


METHODS
M235T and T174M polymorphisms were analyzed using PCR-RFLP methods.


RESULTS
The carrier frequency of M235T polymorphism in the AGT gene was 73% in hypertensive patients and 34.21% in normotensive patients (OR 5.2, 95%CI [2.72-9.93], p<0.01, chi2 test). The carrier frequency of T174M polymorphism in the AGT gene was 42% in hypertensive patients and 11.84% in normotensive patients (OR 5.39, 95%CI [2.41-12.01], p<0.01, chi2 test).


CONCLUSIONS
Essential arterial hypertension is associated with polymorphisms in the AGT gene, M235T and T174M.
Procopciuc
Lucia Maria
LM
Department of Medical Biochemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Lprocopciuc@personal.ro
Pop
Dana
D
Zdrenghea
D
D
Jebeleanu
Gh
G
D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D012383:Romania
D000808:Angiotensinogen