Facile purification of honokiol and its antiviral and cytotoxic properties.
A separation of honokiol 1 from the closely structurally related magnolol 2 was developed. Honokiol demonstrated weak activity against HIV-1 in human lymphocytes.
Amblard
Franck
F
Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Delinsky
David
D
Arbiser
Jack L
JL
Schinazi
Raymond F
RF
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000821:virology; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D014709:Vero Cells; D000498:Allyl Compounds; D010636:Phenols
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols