Neocimicigenosides A and B, cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their effects on CRF-stimulated ACTH secretion from AtT-20 cells.
Two new cycloartane glycosides, named neocimicigenosides A (1) and B (2), were isolated from the rhizomes of Cimicifuga racemosa. The structures of 1 and 2 were determined on the basis of extensive spectroscopic analysis and enzymatic hydrolysis followed by chromatographic and spectroscopic analyses to be (16S,23R,24S)-24-acetoxy-16,23:16,25-diepoxy-15alpha-hydroxycycloartan-3beta-yl alpha-L-arabinopyranoside (1) and (16S,23R,24S)-24-acetoxy-16,23:16,25-diepoxy-15alpha-hydroxycycloartan-3beta-yl beta-D-xylopyranoside (2), respectively. Neocimicigenosides A and B enhanced CRF-stimulated ACTH secretion from AtT-20 cells.
Mimaki
Yoshihiro
Y
Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Hachioji, Tokyo 192-0392, Japan. mimakiy@ps.toyaku.ac.jp
Nadaoka
Isao
I
Yasue
Masaaki
M
Ohtake
Yasuyuki
Y
Ikeda
Mitsuo
M
Watanabe
Kazuki
K
Sashida
Yutaka
Y
D000324:Adrenocorticotropic Hormone / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D031885:Cimicifuga / Q000737:chemistry*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D006027:Glycosides; D014315:Triterpenes; C511669:neocimicigenoside A; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; C511670:neocimicigenoside B