title: Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of adjuvant radiotherapy after transoral laser microsurgery for advanced recurrent head-and-neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  Between 1988 and 2000, 37 patients with advanced local recurrences (23 local and 14 locoregional recurrences) of HNSCC without distant metastases were treated in curative intent with organ-preserving transoral laser microsurgery and adjuvant radiotherapy (before 1994 split-course radiotherapy with carboplatinum, after 1994 conventional radiotherapy). Initial therapy of the primary (8.1% oral cavity, 35.1% oropharynx, 13.5% hypopharynx, and 43.3% larynx) before relapse was organ-preserving transoral laser microsurgery without any adjuvant therapy.
  
  
  RESULTS
  After a median follow-up of 124 months, the 5-year overall survival rate was 21.3%, the loco-regional control rate 48.3%, respectively. In multivariate analysis, stage of original primary tumor (Stage I/II vs. Stage III/IV), and patient age (<58 years vs. >or=58 years) showed statistically significant impact on prognosis. In laryngeal cancer, larynx preservation rate after treatment for recurrent tumor was 50% during follow-up.
  
  
  CONCLUSIONS
  Our data show that organ-preserving transoral laser microsurgery followed by adjuvant radiotherapy is a curative option for patients who have advanced recurrence after transoral laser surgery and is an alternative to radical treatment.
authors.affiliation: Department of Radiotherapy, University of Göttingen, Göttingen, Germany, and Départmentde Cancérologie, Hôpital Morvan, Centre Hospitalier Universitaire de Brest, France. hchrist@gwdg.de
authors.forename: Hans
authors.initials: H
authors.lastname: Christiansen
authors.forename: Robert Michael
authors.initials: RM
authors.lastname: Hermann
authors.forename: Alexios
authors.initials: A
authors.lastname: Martin
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Florez
authors.forename: Elke
authors.initials: E
authors.lastname: Kahler
authors.forename: Mirko
authors.initials: M
authors.lastname: Nitsche
authors.forename: Andrea
authors.initials: A
authors.lastname: Hille
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steiner
authors.forename: Clemens F
authors.initials: CF
authors.lastname: Hess
authors.forename: Olivier
authors.initials: O
authors.lastname: Pradier
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D016879:Salvage Therapy; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D006441:Hemoglobin A; D016190:Carboplatin