title: Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus.
abstract: Approximately one-third of the open reading frames encoded in the Sulfolobus solfataricus genome were differentially expressed within 5 min following an 80 to 90 degrees C temperature shift at pH 4.0. This included many toxin-antitoxin loci and insertion elements, implicating a connection between genome plasticity and metabolic regulation in the early stages of stress response.
authors.affiliation: Dept. of Chemical and Biomolecular Engineering, North Carolina State University, EB-1, 911 Partners Way, Box 7905, Raleigh, NC 27695-7905, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Tachdjian
authors.forename: Robert M
authors.initials: RM
authors.lastname: Kelly
mesh_terms: D000992:Antitoxins / Q000235:genetics / Q000378:metabolism; D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism*; D018869:Heat-Shock Response; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D019642:RNA, Archaeal / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D048229:Sulfolobus solfataricus / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors; D014118:Toxins, Biological / Q000235:genetics / Q000378:metabolism
chemical_list: D000992:Antitoxins; D019843:Archaeal Proteins; D019642:RNA, Archaeal; D012333:RNA, Messenger; D014118:Toxins, Biological