title: Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia.
abstract: Oblongifolins A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam. The bark was also found to contain the known compounds camboginol and guttiferone B. Extraction of the leaves gave 2 and camboginol. Details of the structure elucidation of 2-5 and stereochemical comparisons with known natural derivatives of general formula 1a,b are presented. The biological activity of these compounds concerning interactions with tubulin was investigated.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Hamed
authors.forename: Solenn
authors.initials: S
authors.lastname: Brajeul
authors.forename: Florence
authors.initials: F
authors.lastname: Mahuteau-Betzer
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mons
authors.forename: Bernard
authors.initials: B
authors.lastname: Delpech
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Christian
authors.initials: C
authors.lastname: Marazano
mesh_terms: D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000302:isolation & purification; D014404:Tubulin / Q000187:drug effects; D014744:Vietnam
chemical_list: D013729:Terpenes; D014404:Tubulin; D010696:Phloroglucinol; C054597:garcinol