title: Screening younger women with a family history of breast cancer--does early detection improve outcome?
abstract: Women with a family history are often offered mammographic surveillance at an earlier age and with greater frequency than those in the National Breast Screening Programme. In this study, we compared the survival of 62 breast cancer patients diagnosed in the context of a family history clinic offering 12-18 monthly mammographic screening with that of 1108 patients of the same age range but having no exposure to screening. We subtracted the expected additional observation time due to lead time from the survival of the screen-detected cases. Survival was significantly better in the family history group with relative hazards of 0.19 (95% CI 0.07-0.52, P<0.001) for breast cancer death and 0.19 (95% CI 0.08-0.43, P<0.001) for disease-free survival. After correcting for lead-time, the relative hazards were 0.24 (95% CI 0.09-0.66, P=0.005) for breast cancer death and 0.25 (95% CI 0.11-0.57, P<0.001) for disease-free survival. These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies.
authors.affiliation: Breast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Maurice
authors.forename: D G R
authors.initials: DG
authors.lastname: Evans
authors.forename: A
authors.initials: A
authors.lastname: Shenton
authors.forename: L
authors.initials: L
authors.lastname: Ashcroft
authors.forename: A
authors.initials: A
authors.lastname: Baildam
authors.forename: L
authors.initials: L
authors.lastname: Barr
authors.forename: G
authors.initials: G
authors.lastname: Byrne
authors.forename: N
authors.initials: N
authors.lastname: Bundred
authors.forename: C
authors.initials: C
authors.lastname: Boggis
authors.forename: M
authors.initials: M
authors.lastname: Wilson
authors.forename: S W
authors.initials: SW
authors.lastname: Duffy
authors.forename: A
authors.initials: A
authors.lastname: Howell
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D042241:Early Diagnosis; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing / Q000379:methods*; D006579:Heterozygote; D006801:Humans; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D010375:Pedigree; D016019:Survival Analysis; D016896:Treatment Outcome