title: The physiological regulation of uncoupling proteins.
abstract: Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.
authors.affiliation: Buck Institute for Age Research, Mitochondrial Physiology, Novato, CA 94945, USA. dnicholls@buckinstitute.org
authors.forename: David G
authors.initials: DG
authors.lastname: Nicholls
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D015640:Ion Channel Gating; D007473:Ion Channels; D015227:Lipid Peroxidation; D008565:Membrane Proteins / Q000502:physiology*; D024101:Mitochondrial Proteins; D011522:Protons; D011685:Purine Nucleotides / Q000378:metabolism; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D005227:Fatty Acids; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011522:Protons; D011685:Purine Nucleotides; D000071256:Uncoupling Protein 1