[Metabolic causes of bone mineralisation disorders in patients with anorexia nervosa].
OBJECTIVE
To assess the influence of metabolic disorders on densitometric parameters in patients with anorexia nervosa.


METHODS
Thirty patients with diagnosis of anorexia nervosa and twenty six healthy females from control group participated in the study. Serum calcium, phosphorus, estradiol, cortisol, osteocalcin and C-terminal telopeptide of collagen type I concentrations were estimated. Urine sample was analysed for 24 hrs excretion of calcium and phosphorus. Lumbar bone mineral density and Z-score were assessed by DEXA.


RESULTS
Statistical analysis showed the presence of positive correlation between densitometric parameters and serum concentrations of estradiol and phosphorus and negative correlation with serum concentration of cortisol. The duration of anorexia nervosa and secondary amenorrhea correlated negatively with densitometric parameters. There was no correlation between bone turnover markers and densitometric parameters.


CONCLUSIONS
Current data are in agreement with hypothesis of multifactorial ethiopathogenesis of osteoporosis in anorexia nervosa.
Smiech
Anna
A
Klinika Zaburzeń Afektywnych i Psychiatrii Młodziezowej, Centralny Szpital Kliniczny, ul. Czechosłowacka 8/10, 92-216 Łódź, Poland.
Rabe-Jabłońska
Jolanta
J
Zygmunt
Arkadiusz
A
Lewiński
Andrzej
A
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000453:epidemiology* / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology* / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000652:urine; D015984:Causality; D003094:Collagen / Q000097:blood / Q000652:urine; D024042:Collagen Type I / Q000097:blood / Q000652:urine; D015897:Comorbidity; D004958:Estradiol / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D015675:Osteocalcin / Q000097:blood / Q000652:urine; D010455:Peptides / Q000097:blood / Q000652:urine; D010758:Phosphorus / Q000097:blood / Q000652:urine
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D010758:Phosphorus; D004958:Estradiol; D003094:Collagen; D002118:Calcium; D006854:Hydrocortisone