Proteomics of breast cancer: principles and potential clinical applications.
Progresses in screening, early diagnosis, prediction of aggressiveness and of therapeutic response or toxicity, and identification of new targets for therapeutic will improve survival of breast cancer. These progresses will likely be accelerated by the new proteomic techniques. In this review, we describe the different techniques currently applied to clinical samples of breast cancer and the most important results obtained with the two most popular proteomic approaches in translational research (tissue microarrays and SELDI-TOF).
Bertucci
François
F
Centre de Recherche en Cancérologie de Marseille, Département d'Oncologie Moléculaire, Institut Paoli-Calmettes, IPC, and UMR599 INSERM, 13009 Marseille, France. bertuccif@marseille.fnclcc.fr
Birnbaum
Daniel
D
Goncalves
Anthony
A
D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis / Q000378:metabolism; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D046888:Tissue Array Analysis
D009363:Neoplasm Proteins