Structures of bioactive carexanes from the roots of Carex distachya Desf.
Four metabolites, named carexanes I-L, have been isolated from the roots of Carex distachya Desf, an herbaceous plant living in the Mediterranean maquis, together with three known compounds, already isolated from the aerial part of the plant. All the compounds have been characterized on the basis of their spectroscopic properties. Carexane I derived from the lose of a proton from the C-18 carbon of an intermediate isopropyl cation. Its stereostructure has been elucidated by Mosher's method, NOESY/ROESY experiments and computational calculations. The bioactivity on seed germination and root/shoot growth of Lactuca sativa L. of all the isolated compounds is also reported.
Fiorentino
Antonio
A
Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy. antonio.fiorentino@unina2.it
D'Abrosca
Brigida
B
Pacifico
Severina
S
Natale
Angela
A
Monaco
Pietro
P
D031255:Carex Plant / Q000737:chemistry*; D018545:Lactuca / Q000187:drug effects / Q000254:growth & development; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry / Q000187:drug effects / Q000254:growth & development; D018520:Plant Shoots / Q000187:drug effects / Q000254:growth & development; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification
D010936:Plant Extracts; D013267:Stilbenes