[Non-small cell lung cancer (NSCLC): the evolution of neo-adjuvant chemotherapy in the last 15 years].
Retrospective analysis of surgical data-base of NSCLC have showed that, except stage IA, the prognosis of locally advanced disease is very poor if treated with surgery and/or radiotherapy and it is probably due to distant micrometastasis present at the diagnosis. The aim of neo-adjuvant chemotherapy is to address early the distant micrometastasis and to allow, through a downstaging, surgical resection of tumor not suitable to surgery or partially respectable at diagnosis.
Santo
Antonio
A
Divisione Clinicizzata di Oncologia Medica, Ospedale Civile Maggiore, Verona. antonio.santo@univr.it
Genestreti
Giovenzio
G
Fiorio
Elena
E
Terzi
Alberto
A
Lonardoni
Alessandro
A
Calabrò
Francesco
F
Campaldini
Barbara
B
Colaluca
Panfilo
P
Molino
Annamaria
A
Cetto
Gian Luigi
GL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000601:surgery; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome