title: Accelerated partial breast irradiation using proton beams: Initial dosimetric experience.
abstract: OBJECTIVE
  The unique dosimetric features of proton radiotherapy make it an attractive modality for normal tissue sparing. We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI).
  
  
  METHODS
  From March 2004 to June 2005, 25 patients with tumors < or =2 cm and negative axillary nodes were treated with proton 3D-CPBI. The prescribed dose was 32 Cobalt Gray Equivalents (CGE) in 4 CGE fractions given twice daily. One to three fields were used to provide adequate planning target volume (PTV) coverage and dose homogeneity.
  
  
  RESULTS
  Excellent PTV coverage and dose homogeneity were obtained in all patients with one to three proton beams. The median PTV receiving 95% of the prescribed dose was 100%. Dose inhomogeneity exceeded 10% in only 1 patient (4%). The median volume of nontarget breast tissue receiving 50% of the prescribed dose was 23%. Median volumes of ipsilateral lung receiving 20 CGE, 10 CGE, and 5 CGE were 0%, 1%, and 2%, respectively. The contralateral lung and heart received essentially no radiation dose. Cost analysis suggests that proton 3D-CPBI is only modestly more expensive (25%) than traditional whole-breast irradiation (WBI).
  
  
  CONCLUSIONS
  Proton 3D-CPBI is technically feasible, providing both excellent PTV coverage and normal tissue sparing. It markedly reduces the volume of nontarget breast tissue irradiated compared with photon-based 3D-CPBI, addressing a principle disadvantage of external-beam approaches to PBI. As proton therapy becomes more widely available, it may prove an attractive tool for 3D-CPBI.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ataghian@partners.org
authors.forename: Alphonse G
authors.initials: AG
authors.lastname: Taghian
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Kozak
authors.forename: Angela
authors.initials: A
authors.lastname: Katz
authors.forename: Judith
authors.initials: J
authors.lastname: Adams
authors.forename: Hsiao-Ming
authors.initials: HM
authors.lastname: Lu
authors.forename: Simon N
authors.initials: SN
authors.lastname: Powell
authors.forename: Thomas F
authors.initials: TF
authors.lastname: DeLaney
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003365:Costs and Cost Analysis; D005240:Feasibility Studies; D005260:Female; D006321:Heart / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008875:Middle Aged; D011446:Prospective Studies; D061766:Proton Therapy; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000191:economics; D020266:Radiotherapy, Conformal / Q000191:economics / Q000379:methods*; D011522:Protons
chemical_list: D011522:Protons