[Protective effect of dl-tetrahydropalmatine on liver injury induced by carbon tetrachloride in mice].
OBJECTIVE
To study the protective effect of dl-tetrahydropalmatine(dl-THP) on liver injury induced by carbon tetrachloride (CC4) in mice.


METHODS
Mice were administracted with dl-tetrahydropalmatine ip 20, 40 mg x kg(-1) daily for 9 d respectively, and then actue liver injury model was induced by 0.1% carbon tetrachloride ip 20 mL x kg(-1). The mice were killed 17 h after injection ip of CCl4, serum alanine and aspartate aminotransferase (ALT and AST) activity were measured, and maleic dialdehyde (MDA) and superoxide dismutase(SOD) activity in liver were detected.


RESULTS
dl-THP significantly reduced the level of serum ALT and AST, inhibited lipoperxidation in liver, while increased SOD activity in liver tissue. Degeneration of hepatocytes was obviously prevented in mice treated with dl-THP, and the liver histological structure was well maintained.


CONCLUSIONS
dl-THP has inhibitory effects on liver injury induced by CCl4 in mice. The mechanisms may be related with its effects of reducing lipid peroxidation product.
Min
Qing
Q
Pharmacy College of Xianning University, Xianning 437100, China.
Bai
Yu-Ting
YT
Shu
Si-Jie
SJ
Ren
Ping
P
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism*
D001600:Berberine Alkaloids; D020011:Protective Agents; C014215:tetrahydropalmatine; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase