title: Chromatin in pluripotent embryonic stem cells and differentiation.
abstract: Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. meshoree@mail.nih.gov
authors.forename: Eran
authors.initials: E
authors.lastname: Meshorer
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D006657:Histones / Q000378:metabolism; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones