title: Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography.
abstract: Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA.
authors.forename: Ben
authors.initials: B
authors.lastname: Brooksby
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Shudong
authors.initials: S
authors.lastname: Jiang
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
authors.forename: Subhadra
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Christine
authors.initials: C
authors.lastname: Kogel
authors.forename: Tor D
authors.initials: TD
authors.lastname: Tosteson
authors.forename: John
authors.initials: J
authors.lastname: Weaver
authors.forename: Steven P
authors.initials: SP
authors.lastname: Poplack
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000368:Aged; D001940:Breast / Q000166:cytology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014054:Tomography / Q000379:methods*
chemical_list: D006454:Hemoglobins