title: [Mechanism of cartilage matrix remodeling by Wnt].
abstract: Wnt proteins play central roles in a variety of developmental processes and regulate cell differentiation, cell fate and cell proliferation. It has been also demonstrated that Wnt proteins profoundly participate in cartilage development. Interestingly, activation of Wnt/beta-catenin signaling in chondrocytes induces a profile of matrix degradation enzymes quite similar to that of cartilage matrix degradation such as osteoarthritis and rheumatoid arthritis. In this review we discuss the involvement of Wnt/beta-catenin signaling in pathological cartilage matrix degradation.
authors.affiliation: Thomas Jefferson University, Department of Orthopaedic Surgery.
authors.forename: Takahito
authors.initials: T
authors.lastname: Yuasa
authors.forename: Motomi Enomoto
authors.initials: ME
authors.lastname: Iwamoto
mesh_terms: D000818:Animals; D002356:Cartilage / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology; D051379:Mice; D051153:Wnt Proteins / Q000502:physiology*
chemical_list: D051153:Wnt Proteins