Anticancer activity of tirucallane triterpenoids from Amoora dasyclada.
A new tetranortriterpene 3alpha-acetoxy-24,25,26,27-tetranortirucalla-7-ene-23(21)-lactone (3), and eleven other compounds were isolated from the twigs of Amoora dasyclada. The structure of compound 3 was identified on the basis of spectroscopic data, and the bioactive experiments of 1 and 3-5 against AGZY 83-a (human lung cancer cells) and SMMC-7721 (human liver cancer cells) are documented. Among them, compound 5 exhibited a strong activity against SMMC-7721.
Yang
Shu-Min
SM
Xishuangbanna Tropical Botanical Garden, the Chinese Academy of Sciences, Kunming, Yunnan, PR China.
Song
Qi-Shi
QS
Qing
Chen
C
Wu
Da-Gang
DG
Liu
Xi-Kui
XK
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002681:China; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes