title: SAA1 alpha/alpha alleles in amyloidosis.
abstract: BACKGROUND
  Amyloidosis, mainly AA type, is one of the common diseases in nephrology clinics in Turkey. AA type amyloidosis is a complication of various chronic infections or inflammatory diseases such as familial Mediterranean fever (FMF), rheumatoid arthritis (RA), tuberculosis and bronchiectasis. A controversy exists in the literature regarding the relationship between SAA1 genotypes and AA type amyloidosis. This study aimed to investigate SAA1 gene polymorphism in different patient groups: 1) amyloidosis, 2) FMF and 3) healthy controls.
  
  
  METHODS
  Eighty-two patients from the three groups were included in the study: 1) amyloidosis, 2) FMF without amyloidosis, and 3) healthy controls. SAA1 genotypes were studied by the polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  The homozygous alpha/alpha genotype is the most common SAA1 genotype among patient groups with amyloidosis, and the alpha/alpha genotype frequency is significantly higher than in healthy controls (68 vs. 38%, p<0.05).
  
  
  CONCLUSIONS
  The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
authors.affiliation: Ondokuz Mayis University School of Medicine, Samsun, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Kelkitli
authors.forename: Birsen
authors.initials: B
authors.lastname: Bilgici
authors.forename: Bülent
authors.initials: B
authors.lastname: Tokgöz
authors.forename: Melda
authors.initials: M
authors.lastname: Dilek
authors.forename: Abdülkerim
authors.initials: A
authors.lastname: Bedir
authors.forename: Ilkser
authors.initials: I
authors.lastname: Akpolat
authors.forename: Cengiz
authors.initials: C
authors.lastname: Utas
authors.forename: Tekin
authors.initials: T
authors.lastname: Akpolat
mesh_terms: D000328:Adult; D000483:Alleles; D000686:Amyloidosis / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044466:Asian People; D010505:Familial Mediterranean Fever / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014421:Turkey; D044465:White People
chemical_list: D000685:Serum Amyloid A Protein