Harnessing actin dynamics for clathrin-mediated endocytosis.
Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane--namely endocytosis--has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.
Kaksonen
Marko
M
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202, USA.
Toret
Christopher P
CP
Drubin
David G
DG
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D011554:Pseudopodia / Q000378:metabolism / Q000502:physiology
D000199:Actins; D002966:Clathrin