Complex, multimodal behavioral profile of the Homer1 knockout mouse.
Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined the behavior of male Homer1 knockout (KO) mice compared with wild-type (WT) and heterozygous mice using a battery of 10 behavioral tests probing sensory, motor, social, emotional and learning/memory functions. KO mice showed mild somatic growth retardation, poor motor coordination, enhanced sensory reactivity and learning deficits. Heterozygous mice showed increased aggression in social interactions with conspecifics. The distribution of mGluR5 and N-methyl-D-aspartate receptors (NMDA) receptors appeared to be unaltered in the hippocampus (HIP) of Homer1 KO mice. The results indicate an extensive range of disrupted behaviors that should contribute to the understanding of the Homer1 gene in brain development and behavior.
Jaubert
P J
PJ
Children's Center for Environmental Health & Department of Neurological Surgery, University of California Davis, CA 95616, USA.
Golub
M S
MS
Lo
Y Y
YY
Germann
S L
SL
Dehoff
M H
MH
Worley
P F
PF
Kang
S H
SH
Schwarz
M K
MK
Seeburg
P H
PH
Berman
R F
RF
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D049628:Body Size / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D005518:Food Preferences / Q000502:physiology; D006579:Heterozygote; D006624:Hippocampus / Q000378:metabolism*; D000072233:Homer Scaffolding Proteins; D007100:Imitative Behavior; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009048:Motor Skills / Q000502:physiology*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D045442:Rotarod Performance Test; D012919:Social Behavior; D013045:Species Specificity
D002352:Carrier Proteins; C578936:Grm5 protein, mouse; D000072233:Homer Scaffolding Proteins; C000606623:Homer1 protein, mouse; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate