title: [Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese].
abstract: OBJECTIVE
  To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.
  
  
  METHODS
  Polymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.
  
  
  RESULTS
  A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).
  
  
  CONCLUSIONS
  The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.
authors.affiliation: Department of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Ya-jun
authors.initials: YJ
authors.lastname: Deng
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Yan
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Wu
authors.forename: Song-nian
authors.initials: SN
authors.lastname: Hu
authors.forename: Bo-feng
authors.initials: BF
authors.lastname: Zhu
authors.forename: Sheng-bin
authors.initials: SB
authors.lastname: Li
authors.forename: Xiu-qing
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013167:Spondylitis, Ankylosing / Q000235:genetics
chemical_list: D015796:HLA-B27 Antigen