title: Radical subtotal pancreatic resection, including splenectomy, is an effective one-off treatment for infected pancreatic necrosis.
abstract: BACKGROUND
  Pancreatic resection for severe acute necrotizing pancreatitis has been associated with prohibitive mortality rates and has been hence replaced by piecemeal debridement, either by the open or the laparoscopic technique. We report the results of deliberate subtotal pancreatectomy with splenectomy for infected pancreatic necrosis.
  
  
  METHODS
  Six-year prospective audit of patients treated by a single surgeon, with an interest in pancreatic disease, within a Low Volume Hospital (LVH) setting. Results are presented as median (IQR).
  
  
  RESULTS
  During the study period 18 patients (9 males) with complicated severe acute pancreatitis underwent radical pancreatic resection. The median age was 61 years (range 36-69). The median time to operation after presentation was 27 days (range 2-74). Microbiological culture confirmed infection in 14 (78%) patients. Three patients (17%) died within 30 days of operation. Twelve of the 15 survivors (80%) underwent a single operative procedure. Three patients required a further laparotomy, of whom 2 required colectomy for ischemia. Median hospital and ICU stays were 43 (range 30-57) and 5 (range 4-6) days respectively. Six patients (40% of survivors) developed an infection of the left half of the chevron incision; however, all wounds were fully healed within 3 months. Long-term follow-up of survivors (n=14) revealed 8 (57%) to need at least occasional pancreatic enzyme supplementation and 5 (36%) to have diabetes mellitus. Two patients (14%) developed an incisional hernia.
  
  
  CONCLUSIONS
  Radical resection of pancreas and spleen, combined with postoperative irrigation, was associated with comparatively low rates of morbidity and mortality for patients with infected pancreatic necrosis in a LVH setting.
authors.affiliation: Consultant Gastrointestinal Surgeon, Department of Surgery, York Hospital, Wigginton Road, York YO31 8HE, UK.
authors.forename: Justin
authors.initials: J
authors.lastname: Davies
authors.forename: Stevan G
authors.initials: SG
authors.lastname: Stojkovic
authors.forename: David
authors.initials: D
authors.lastname: Duffy
authors.forename: David J
authors.initials: DJ
authors.lastname: Alexander
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications*; D003646:Debridement; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods*; D019283:Pancreatitis, Acute Necrotizing / Q000382:microbiology / Q000601:surgery*; D011182:Postoperative Care; D011183:Postoperative Complications; D013156:Splenectomy