title: Evacuation of the cervix after methotrexate administration in the treatment of cervical pregnancy: five cases.
abstract: Case studies of five consecutive patients with cervical pregnancy treated with a standard protocol are presented. The aim was to evaluate the place of evacuation with curettage followed or not by cervical tamponade as an additional modality in patients with cervical pregnancies treated initially with methotrexate (MTX). The five patients with cervical pregnancies were treated with local injection and systemic administration of MTX, while in four of them additional cervical evacuation was performed. In two patients, with a gestational age of more than 9 weeks, cervical tamponade was additionally applied. No complications occurred during evacuation with curettage after MTX, and two women managed to become pregnant spontaneously and progressed to full term.
authors.affiliation: 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. grimbi@med.auth.gr
authors.forename: Grigoris
authors.initials: G
authors.lastname: Grimbizis
authors.forename: Kostantinos
authors.initials: K
authors.lastname: Chatzigeorgiou
authors.forename: Tryfon
authors.initials: T
authors.lastname: Tsalikis
authors.forename: Apostolos
authors.initials: A
authors.lastname: Athanasiadis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Theodoridis
authors.forename: John N
authors.initials: JN
authors.lastname: Bontis
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D002584:Cervix Uteri; D003131:Combined Modality Therapy; D005260:Female; D005298:Fertility; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D014463:Ultrasonography; D014619:Vacuum Curettage
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate