Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis.
EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNgamma and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.
Staykova
Maria A
MA
Neurosciences Research Unit, The Canberra Hospital, Canberra, and The John Curtin School of Medical Research, Australian National University, Australia. maria.staykova@anu.edu.au
Fordham
Susan A
SA
Bartell
Gavin J
GJ
Cowden
William B
WB
Willenborg
David O
DO
D000367:Age Factors; D000818:Animals; D001119:Arginase / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000096:biosynthesis; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D026361:Reactive Nitrogen Species / Q000097:blood; D012727:Sex Characteristics; D013154:Spleen / Q000473:pathology
D020030:Nitric Oxide Donors; D026361:Reactive Nitrogen Species; D009569:Nitric Oxide; D007371:Interferon-gamma; D001119:Arginase