['Migraine and a hole in the heart': causal relationship between migraine and patent foramen ovale not established].
The relationship between patent foramen ovale (PFO) and migraine is controversial. A common genetic background seems possible, but there is no evidence for a causal relationship. Despite the lack of evidence, PFO closure is recommended in many countries as a remedy for migraine. At present, PFO closure for migraine should only be carried out under strictly controlled clinical trial conditions.
Terwindt
G M
GM
Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden.
Haan
J
J
Bax
J J
JJ
de Bruijn
S F T M
SF
Ferrari
M D
MD
D020022:Genetic Predisposition to Disease; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000601:surgery; D006801:Humans; D008881:Migraine Disorders / Q000209:etiology* / Q000601:surgery; D012307:Risk Factors