title: Effect of artemether administered alone or in combination with praziquantel to mice infected with Plasmodium berghei or Schistosoma mansoni or both.
abstract: The artemisinins have become key drugs for the treatment and control of malaria, particularly within artemisinin-based combination therapies. Since the artemisinins also exhibit antischistosomal properties, their use in areas where malaria and schistosomiasis are co-endemic may have an effect on both diseases and co-infection might alter drug efficacy. We assessed the antimalarial and antischistosomal efficacies of artemether in mice infected with Plasmodium berghei or Schistosoma mansoni or both parasites concurrently. Three oral doses of 400 mg/kg artemether at 14-day intervals reduced total and female S. mansoni worm burdens by 98.7-100%, regardless of a concurrent P. berghei infection. When four daily doses of 55 mg/kg artemether were administered, which is a standard treatment schedule to cure P. berghei-infected mice, significantly lower total and female S. mansoni worm burden reductions were observed (73.1-89.2%). Artemether, administered at both of the above-mentioned treatment schemes, showed excellent antimalarial efficacy with no indications of delayed clearance of P. berghei or recrudescence, also in mice co-infected with S. mansoni. Co-infection with P. berghei had no effect on S. mansoni worm burden reductions following artemether-praziquantel combinations. Our findings point to the need for epidemiological studies in areas where malaria and schistosomiasis co-exist and where artemisinin-based combination therapies are introduced, since artemisinin-based combination therapies as part of a malaria control package may have ancillary benefits against schistosomiasis.
authors.affiliation: Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.
authors.forename: Xiao
authors.initials: X
authors.lastname: Shu-Hua
authors.forename: Jürg
authors.initials: J
authors.lastname: Utzinger
authors.forename: Jacques
authors.initials: J
authors.lastname: Chollet
authors.forename: Marcel
authors.initials: M
authors.lastname: Tanner
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000077549:Artemether; D037621:Artemisinins / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007422:Intestines / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology*; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D010962:Plasmodium berghei / Q000254:growth & development*; D011223:Praziquantel / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000254:growth & development*; D012555:Schistosomiasis mansoni / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology*; D012556:Schistosomicides / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012556:Schistosomicides; D011223:Praziquantel; D000077549:Artemether