title: Total synthesis of (+/-)-paeonilide.
abstract: The total synthesis of paeonilide, a natural anti-PAF (platelet-activating factor) new skeleton monoterpenoid with an IC(50) value of 8 microg/mL, was achieved in 16 steps with 15% overall yield from commercially available 2-hydroxy-4-methylacetophenone. [reaction: see text]
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China.
authors.forename: Chenying
authors.initials: C
authors.lastname: Wang
authors.forename: Jikai
authors.initials: J
authors.lastname: Liu
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Ji
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000098:Acetophenones / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C518270:2-hydroxy-4-methylacetophenone; D000098:Acetophenones; D010972:Platelet Activating Factor; D013729:Terpenes; C416702:paeonilide