Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study.
A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.
Richler
Jennifer
J
University of Michigan, Ann Arbor, 48109-2054, USA.
Luyster
Rhiannon
R
Risi
Susan
S
Hsu
Wan-Ling
WL
Dawson
Geraldine
G
Bernier
Raphael
R
Dunn
Michelle
M
Hepburn
Susan
S
Hyman
Susan L
SL
McMahon
William M
WM
Goudie-Nice
Julie
J
Minshew
Nancy
N
Rogers
Sally
S
Sigman
Marian
M
Spence
M Anne
MA
Goldberg
Wendy A
WA
Tager-Flusberg
Helen
H
Volkmar
Fred R
FR
Lord
Catherine
C
D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D002648:Child; D003142:Communication; D005260:Female; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D015588:Observer Variation; D010290:Parents; D010641:Phenotype; D012043:Regression, Psychology; D012919:Social Behavior; D011795:Surveys and Questionnaires
D022542:Measles-Mumps-Rubella Vaccine