Chordomas and chondrosarcomas of the skull base: results and complications of surgical management.
OBJECTIVE
Chordomas and chondrosarcomas are rare and difficult to treat tumors for which the optimum treatment modality remains controversial. The aim of this study was to evaluate the surgery-related results and complications in a series of patients in whom radical resection was the treatment of choice.


METHODS
The authors conducted a retrospective analysis of the surgery-related results and complications associated with chordoma and chondrosarcoma in 64 patients of whom 33 (52%) had previously undergone some form of treatment. Total or near-total excision was achieved in 56% and this rate increased to 68% in patients without prior treatment. The main complications were postoperative cerebrospinal fluid leakage, intraoperative arterial injury, and new-onset cranial nerve deficits. Arterial injury occurred only and perioperative death occurred more often in patients who had undergone previous treatment.


CONCLUSIONS
Analysis of the results provides support for a policy of radical excision of chordomas and chondrosarcomas at the time of first presentation. A higher incidence of procedure-related complications is found in patients who have already undergone surgery and radiotherapy.
Sekhar
L N
LN
Department of Neurosurgery, The George Washington University Medical Center, Washington, DC, USA.
Pranatartiharan
R
R
Chanda
A
A
Wright
D C
DC
D000328:Adult; D002813:Chondrosarcoma / Q000601:surgery*; D002817:Chordoma / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000601:surgery*; D013353:Subdural Effusion / Q000209:etiology; D016896:Treatment Outcome