[Regulation by vasopressin of NaCl absorption in the renal collecting duct].
In the kidney, the fine control of NaCl absorption takes place in the distal nephron and is controlled by aldosterone and vasopressin. This review summarizes the effects of vasopressin on Na+ transport mediated by the amiloride-sensitive epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel in immortalized or primary cultured cortical collecting duct cells, expressing either the wild-type ENaC subunits, or mutations, or deletions of the PY domain of the beta- or gamma-ENaC subunits responsible for Liddle's syndrome, an inherited form of hypertension due to excessive salt absorption.
Vandewalle
Alain
A
INSERM, U773, Centre de Recherche Biomédicale Bichat-Beaujon (CRB3), BP 416, F-75018 Paris, France.
D000042:Absorption / Q000187:drug effects; D000450:Aldosterone / Q000494:pharmacology / Q000502:physiology; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D053503:Epithelial Sodium Channels; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism; D017136:Ion Transport; D007685:Kidney Tubules, Collecting / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology; D009865:Oocytes; D021122:Protein Subunits; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012965:Sodium Chloride / Q000378:metabolism*; D013577:Syndrome; D014667:Vasopressins / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology; D014982:Xenopus laevis
D002712:Chlorides; D053503:Epithelial Sodium Channels; D021122:Protein Subunits; D011993:Recombinant Fusion Proteins; D015222:Sodium Channels; D014667:Vasopressins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D012965:Sodium Chloride; D000450:Aldosterone; D000584:Amiloride; D003894:Deamino Arginine Vasopressin