title: Effects of bioactive glass on bone augmentation within a titanium cap in rabbit parietal bone.
abstract: BACKGROUND
  The condition of alveolar bone influences the success and subsequent esthetics of implant treatment. This study investigated the early effects of bioactive glass (BG) on bone augmentation within a hemispherical titanium cap in rabbit parietal bone.
  
  
  METHODS
  Twelve adult male Japanese white rabbits were used. One titanium cap (test site) was packed with BG in a collagen gel, and the other (control site) was packed with the collagen gel alone. After 1 and 3 months, animals were euthanized, and the experimental area was examined using fluorescence and light microscopy.
  
  
  RESULTS
  Newly generated bone was observed at 1 and 3 months of healing. Although bone was also generated without BG, newly mineralized bone was generated sooner with BG present for guided bone augmentation than without BG. At 1 and 3 months, the BG was not bioabsorbed completely, and some particles remained.
  
  
  CONCLUSIONS
  New bone is generated at an early stage of bone formation using BG for bone augmentation.
authors.affiliation: Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. nishida@dent.nihon-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nishida
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamada
authors.forename: Masakazu
authors.initials: M
authors.lastname: Murai
authors.forename: Yuka
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Maiko
authors.initials: M
authors.lastname: Oshikawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics; D005898:Glass; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D010294:Parietal Bone / Q000187:drug effects*; D011817:Rabbits; D014025:Titanium / Q000627:therapeutic use
chemical_list: D018786:Bone Substitutes; C425330:bioactive glass 45S5; D014025:Titanium