New coupling reaction of secondary amines, aldehydes, and alkynes catalyzed by an iridium complex.
A new reductive coupling reaction of secondary amines, aldehydes, and alkynes using an iridium complex as catalyst has been developed. For example, dibutylamine was allowed to react with butyraldehyde and 1-octyne in 1,4-dioxane at 50 degrees C under the influence of a catalytic amount of [IrCl(cod)](2) to give the corresponding allylamines such as N,N-dibutyl-2-butylideneoctylamine and N,N-2-tributyl-2-octenylamine in excellent yields. [reaction: see text]
Sakaguchi
Satoshi
S
Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan. satoshi@ipcku.kansai-u.ac.jp
Mizuta
Tomoya
T
Ishii
Yasutaka
Y