title: Effects of subacute boric acid administration on rat kidney tissue.
abstract: OBJECTIVE
  Boron is used in manufacturing processes and numerous consumer products. Clarification of boron toxicity is important because of industrial and consumer exposure to boron and boron-containing compounds. The aim of this study was to observe effects of subacute boric acid administration on rat kidney tissue.
  
  
  METHODS
  A total of 96 male albino Sprague-Dawley rats were used in this study. Seventy-two rats were selected for the experimental group and 24 rats constituted the control group. Experimental group rats were divided into three groups for exposure to three different doses of orally administered boric acid (100-275-400 mg/kg/day). Kidney tissues were removed at the 10th, 30th, and 45th day after sacrificing the rats. Kidney weights, kidney boron concentration and histopathological changes were determined.
  
  
  RESULTS
  In the experimental group, a significant accumulation of boron in kidney tissue was seen, but there was a significant drop in boron concentration on the 45th day compared with the 30th day. Histopathological degenerative changes were observed especially in the proximal tubule cells that were dose- and time-dependent.
  
  
  CONCLUSIONS
  Subacute boric acid exposure caused dose-dependent histopathological changes in kidney tissue.
authors.affiliation: Department of Histology-Embryology, Ankara University, School of Medicine, Turkey. bizdens@yahoo.com
authors.forename: Bizden Tavil
authors.initials: BT
authors.lastname: Sabuncuoglu
authors.forename: Pelin Aribal
authors.initials: PA
authors.lastname: Kocaturk
authors.forename: Onder
authors.initials: O
authors.lastname: Yaman
authors.forename: Guzin Ozelci
authors.initials: GO
authors.lastname: Kavas
authors.forename: Meral
authors.initials: M
authors.lastname: Tekelioglu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001888:Boric Acids / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001888:Boric Acids; C032688:boric acid