title: Aseptic loosening, not only a question of wear: a review of different theories.
abstract: Today, aseptic loosening is the most common cause of revision of major arthroplasties. Aseptic loosening accounts for more than two-thirds of hip revisions and almost one-half of knee revisions in Sweden. Several theories on the cause of aseptic loosening have been proposed. Most of these theories, however, are based on empiric observations, experimental animal models or anecdotal cases. In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory.
authors.affiliation: Department of Biomaterials/Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden. mikael.sundfeldt@vgregion.se
authors.forename: Mikael
authors.initials: M
authors.lastname: Sundfeldt
authors.forename: Lars V
authors.initials: LV
authors.lastname: Carlsson
authors.forename: Carina B
authors.initials: CB
authors.lastname: Johansson
authors.forename: Peter
authors.initials: P
authors.lastname: Thomsen
authors.forename: Christina
authors.initials: C
authors.lastname: Gretzer
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000295:instrumentation; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000295:instrumentation; D001843:Bone Cements; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology; D002516:Ceramics; D019544:Equipment Failure Analysis; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects; D010316:Particle Size; D011095:Polyethylenes; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D013499:Surface Properties
chemical_list: D001843:Bone Cements; D011095:Polyethylenes