Asymmetric silaboration of terminal allenes bearing alpha-stereogenic centers: stereoselection based on "reagent control".
A highly enantioface-selective silaboration of allenes having stereogenic centers at the alpha-positions of the double bonds has been achieved using a combination of a chiral silylborane (-)-2 and a chiral Pd/(R)-3 catalyst. The chiral reagent system efficiently controlled the stereochemistry of the new stereogenic centers even in the reactions of mismatched combinations. [reaction: see text]
Ohmura
Toshimichi
T
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Suginome
Michinori
M