Current concepts of cell-cycle regulation and its relationship to oocyte maturation, fertilization and embryo development.
Genetic and biochemical approaches have contributed to an explosion of literature on cell-cycle control. Regulation of the cell-cycle is controlled by a series of kinases and phosphatases. Key control points are during the G(1)-S and G(2)-M transitions. During both transitions, cyclins interact with a specific kinase to allow a cell to pass through that phase. The meiotic maturation of oocytes, fertilization and embryo development are all events influenced by cell-cycle regulation. Understanding cell-cycle control should provide new ways for gamete and embryo biologists to approach culture and development problems.
Parrish
J J
JJ
Department of Meat and Animal Science, University of Wisconsin-Madison Madison, WI 53706, USA.
Kim
C I
CI
Bae
I H
IH