Delayed onset of odor detection in neonatal mice lacking tenascin-C.
The olfactory bulb is one of the few regions in the adult mammalian forebrain in which neurons are constitutively replaced throughout life. New neurons generated in the subventricular zone migrate long distances along the rostral migratory stream to the olfactory bulb where they differentiate into interneurons. Neuronal precursor generation, migration and incorporation into the bulbar network occur in an environment rich in extracellular matrix molecules. We investigated the potential role of one of the constituents of the extracellular matrix, tenascin-C (TNC), in bulbar neurogenesis and olfactory performance using TNC-deficient mice. We found that TNC deficiency resulted in a delayed onset of olfactory responses in neonatal animals. This delay normalized at around postnatal day 10. Interestingly, this delay in early olfactory performance was not due to impaired bulbar neurogenesis as proliferation, migration, incorporation and fate determination of newborn bulbar interneurons were normal in TNC-deficient animals. Thus, we conclude that a constitutive lack of TNC does not affect bulbar neurogenesis, but instead leads to ontogenetically early impairments in olfactory detection.
de Chevigny
Antoine
A
Laboratory of Perception and Memory, CNRS URA 2182, Pasteur Institute, 25 rue du Dr. Roux, 75015 Paris Cedex, France.
Lemasson
Morgane
M
Saghatelyan
Armen
A
Sibbe
Miriam
M
Schachner
Melitta
M
Lledo
Pierre-Marie
PM
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D012678:Sensation Disorders / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D012903:Smell / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D019063:Tenascin / Q000172:deficiency / Q000235:genetics*
D019063:Tenascin