Autophagy: A protective mechanism in response to stress and inflammation.
Autophagy is one of the intracellular systems that is responsible for protein trafficking (degradation/recycling) in eukaryotic cells. This ubiquitous process contributes to cytosolic homeostasis, but its deregulation is often associated with various pathologies, including neurodegenerative diseases and cancer and pathologies with an altered inflammatory response. This review provides an overview of autophagy and discusses its regulation, function and future therapeutic possibilities, with a focus on the role of autophagy in inflammation.
Heymann
Dominique
D
INSERM, Eri 7, Nantes F-44035, France. dominique.heymann@univ-nantes.fr
D000818:Animals; D017209:Apoptosis; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D001424:Bacterial Infections / Q000378:metabolism / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D020123:Sirolimus / Q000031:analogs & derivatives / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism* / Q000473:pathology; D014777:Virus Diseases / Q000378:metabolism / Q000473:pathology
D047428:Protein Kinase Inhibitors; D011506:Proteins; C401859:temsirolimus; D046988:Proteasome Endopeptidase Complex; D020123:Sirolimus