title: Similarity searches in genome-wide numerical data sets.
abstract: We present psi-square, a program for searching the space of gene vectors. The program starts with a gene vector, i.e., the set of measurements associated with a gene, and finds similar vectors, derives a probabilistic model of these vectors, then repeats search using this model as a query, and continues to update the model and search again, until convergence. When applied to three different pathway-discovery problems, psi-square was generally more sensitive and sometimes more specific than the ad hoc methods developed for solving each of these problems before.
authors.affiliation: Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA. galina_glazko@urmc.rochester.edu
authors.forename: Galina
authors.initials: G
authors.lastname: Glazko
authors.forename: Michael
authors.initials: M
authors.lastname: Coleman
authors.forename: Arcady
authors.initials: A
authors.lastname: Mushegian