Mitochondrial dynamics and Ca2+ signaling.
Recent data shed light on two novel aspects of the mitochondria-Ca2+ liaison. First, it was extensively investigated how Ca2+ handling is controlled by mitochondrial shape, and positioning; a playground also of cell death and survival regulation. On the other hand, significant progress has been made to explore how intra- and near-mitochondrial Ca2+ signals modify mitochondrial morphology and cellular distribution. Here, we shortly summarize these advances and provide a model of Ca2+-mitochondria interactions.
Szabadkai
G
G
Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation and ER-GenTech, University of Ferrara, Italy.
Simoni
A M
AM
Bianchi
K
K
De Stefani
D
D
Leo
S
S
Wieckowski
M R
MR
Rizzuto
R
R
D000818:Animals; D005075:Biological Evolution; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*