title: Leg ulcer recurrence and its risk factors: a duplex ultrasound study before and after vein surgery.
abstract: OBJECTIVE
  Assessment of risk factors for ulcer recurrence in chronic leg ulcer patients treated by varicose vein surgery.
  
  
  METHODS
  Retrospective follow-up study.
  
  
  METHODS
  62 patients, 43 women and 19 men (Median=56.5 years, range 24-77) with the CEAP classifications of C(5)-C(6) and E(P) (primary venous insufficiency).
  
  
  METHODS
  Patients underwent colour duplex ultrasound (CDU) investigation before varicose vein surgery. Post-operatively CDU, ambulatory venous pressure (AVP) and an interview were performed. The median clinical follow-up was 5.5 years (range 2-11 years).
  
  
  RESULTS
  The estimated 5-year ulcer recurrence rate was 19% in all patients. The risk of ulcer recurrence was significantly lower (p<0.05) in legs without residual varices or recurrence. The five year risk of ulcer recurrence depended on the time interval between ulcer appearance and the surgical intervention (index operation), post-operative venous axial reflux and AVP (mmHg). More than 50% of the patients had a calculated probability of ulcer recurrence of less than 3%, but 13% had a probability of more than 23% based on our analysis.
  
  
  CONCLUSIONS
  A long history of venous ulcer is a pre- and post-operative risk factor for recurrent ulceration. Total elimination of incompetent superficial and perforator veins lowers the risk of ulcer recurrence, whereas residual axial reflux increases the risk. Postoperative CDU is effective in identifying patients at risk of ulcer recurrence.
authors.affiliation: Department of Clinical Physiology, Cardiovascular Institute, Göteborg, Sweden. marie.magnusson@vgregion.se
authors.forename: M B
authors.initials: MB
authors.lastname: Magnusson
authors.forename: O
authors.initials: O
authors.lastname: Nelzén
authors.forename: R
authors.initials: R
authors.lastname: Volkmann
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012008:Recurrence; D012039:Regional Blood Flow; D012307:Risk Factors; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D014647:Varicose Ulcer / Q000473:pathology* / Q000503:physiopathology; D014648:Varicose Veins / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014690:Venous Pressure