[Morphological remodeling in atrial fibrillation].
In the recent years, a tremendous amount has been learned about the pathophysiology of atrial fibrillation (AF). AF induces electrophysiological changes in the atria causing a perpetuation of the arrhythmia ("electrical remodeling"). Besides such AF-induced electrophysiological changes, which involve the downregulation of L-type calcium channels and thereby the calcium inward current, AF induces structural and ultrastructural changes in atrial tissue ("structural remodeling"). Calcium-dependent tissue alterations are induced by proteases and phosphatases like calpain and calcineurin. Furthermore, cardiac diseases like hypertension, heart failure, etc. activate the atrial angiotensin II system, and thereby, a progressive pro-arrhythmogenic atrial fibrosis is induced. Besides first clinical trials assessing the antiarrhythmic effects of angiotensin II receptor blockers in patients with AF, experimental data suggest that viral gene transfer can be used to transform fibroblasts to electrically conducting cardiomyocytes. This highly interesting methodology may be helpful to restore electrical conduction in fibrotic cardiac tissue.
Goette
Andreas
A
Klinik für Kardiologie, Angiologie und Pneumologie, Otto-von-Guericke-Universitätsklinik, Magdeburg. andreas.goette@medizin.uni-magdeburg.de
Lendeckel
Uwe
U
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D016275:Atrial Function; D002118:Calcium / Q000378:metabolism; D006332:Cardiomegaly / Q000473:pathology; D015536:Down-Regulation; D005355:Fibrosis / Q000473:pathology; D015316:Genetic Therapy; D006325:Heart Atria / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000473:pathology; D018384:Oxidative Stress; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015398:Signal Transduction
D000889:Anti-Arrhythmia Agents; D002118:Calcium