Hap1 and GABA: thinking about food intake.
GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.
Woods
Stephen C
SC
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA.
Seeley
Randy J
RJ
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000235:genetics / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000378:metabolism* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
C490758:Hap1 protein, mouse; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid