Differential mitochondrial protein expression profiling in neurodegenerative diseases.
Alterations in mitochondrial structure or function have been described in a variety of human diseases for nearly half a century. The complete sequence of the human mitochondrial genome has been published in 1981. The mitochondrial proteome database however, is still incomplete. Here I give a short review on recent advances to determine the complete set of mitochondrial proteins. The main emphasis is put on gel-based proteomic approaches to identify differentially expressed mitochondrial proteins in neurodegenerative diseases.
Gillardon
Frank
F
Boehringer Ingelheim Pharma, CNS Research, Biberach, Germany. Frank.Gillardon@bc.boehringer-ingelheim.com
D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D006801:Humans; D024101:Mitochondrial Proteins / Q000032:analysis*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*
D024101:Mitochondrial Proteins; D020543:Proteome