title: Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment.
abstract: The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.
authors.affiliation: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA.
authors.forename: Claudiu V
authors.initials: CV
authors.lastname: Cotta
authors.forename: Sergej
authors.initials: S
authors.lastname: Konoplev
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Bueso-Ramos
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001854:Bone Marrow Cells / Q000737:chemistry / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000737:chemistry / Q000556:secondary*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor