FR220897 and FR220899, novel antifungal lipopeptides from Coleophoma empetri no. 14573.
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573. This strain was identified as Coleophoma empetri No. 14573 from morphological and physiological characteristics. FR220897 and FR220899 showed antifungal activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis. Furthermore, FR220897 was effective in a murine model of systemic candidiasis.
Kanasaki
Ryuichi
R
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
Abe
Fumie
F
Kobayashi
Motoo
M
Katsuoka
Masaaki
M
Hashimoto
Michizane
M
Takase
Shigehiro
S
Tsurumi
Yasuhisa
Y
Fujie
Akihiko
A
Hino
Motohiro
M
Hashimoto
Seiji
S
Hori
Yasuhiro
Y
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D005285:Fermentation; D005658:Fungi / Q000145:classification* / Q000378:metabolism; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; C511075:FR 220897; C511076:FR 220899; D008074:Lipoproteins; D010456:Peptides, Cyclic