A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations.
The existing literature of continuous chromatographic process indicates the scarcity of processes which allow the continuous separation of a ternary mixture and which also exploit the power of modifier gradients and counter-currency. A new process filling this gap is presented and analyzed using an equilibrium theory model and linear isotherms. The analysis leads to the explicit formulation of an operating region, where 100% purity and yield can be obtained. A normalized flow rate ratio is introduced, which allows an easy description and understanding of the process behavior. The gained insights are verified using a detailed simulation model, where the influence of changes in the normalized flow rate ratios on the unit performance is investigated.
Ströhlein
Guido
G
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Hönggerberg, HCI, 8093 Zurich, Switzerland.
Aumann
Lars
L
Mazzotti
Marco
M
Morbidelli
Massimo
M
D003198:Computer Simulation; D003377:Countercurrent Distribution / Q000379:methods*; D008962:Models, Theoretical; D010455:Peptides / Q000302:isolation & purification
D010455:Peptides