Target-organ damage in adolescent hypertension. Analysis of potential influencing factors, especially nitric oxide and endothelin-1.
OBJECTIVE
To assess the role of the nitric oxide-endothelin imbalance in the development of target-organ damages (carotid intima-media thickness and left ventricular mass index) in adolescent hypertension.


METHODS
125 adolescents--67 hypertensive and 58 normotensive--underwent routine anthropology (height, weight) and blood pressure measurements, and laboratory (glucose, cholesterol and triglyceride levels) testing as well as sampling blood for determination of the plasma concentrations of nitric oxide (NOx) and endothelin-1 (ET-1), followed by measurement of the carotid intima-media thickness (IMT) and left ventricular mass index (LVMI).


RESULTS
Plasma concentration of NOx was significantly lower (27.7+/-13.7 vs. 35.8+/-7.0 micromol/l, respectively, p<0.001) and ET-1 was higher (3.11+/-3.9 vs. 1.09+/-1.07 fmol/ml, respectively, p<0.001) in hypertensive adolescents than that of controls. NOx negatively, endothelin positively correlated with blood pressure values, especially with systolic BP. An inverse relationship has been found between NOx and ET-1 concentrations (r=-0.29, p<0.003). In this adolescent population body weight, systolic blood pressure and plasma ET-1 were the most important factors influencing IMT, whereas LVMI correlated with height and weight and systolic BP of the teenagers.


CONCLUSIONS
NO/endothelin imbalance seems to play a role in the development of hypertension and target-organ damages in adolescence. Further studies are encouraged in order to clarify the pathophysiological role of NO/endothelin imbalance in adolescent hypertension.
Katona
Eva
E
First Department of Medicine, University of Debrecen, Medical and Health Science Centre, Hungary.
Settakis
Georgios
G
Varga
Zsuzsa
Z
Paragh
György
G
Bereczki
Dániel
D
Fülesdi
Béla
B
Páll
Dénes
D
D000293:Adolescent; D000704:Analysis of Variance; D001786:Blood Glucose; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004452:Echocardiography / Q000379:methods; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology*
D001786:Blood Glucose; D019332:Endothelin-1; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol