title: Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst.
abstract: The bifunctional thiourea-tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.
authors.affiliation: Key Laboratory of Drug-Targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Long
authors.forename: Bang-Jing
authors.initials: BJ
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry; D006860:Hydrogen Bonding; D013237:Stereoisomerism; D013379:Substrate Specificity; D013450:Sulfones / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry
chemical_list: D000085:Acetates; D000596:Amino Acids; D003959:Diamines; D013450:Sulfones; C009873:divinyl sulfone; D013890:Thiourea; C007170:cyanoacetic acid