title: Erythema multiforme-like eruption due to carbamates and thiuram.
abstract: Report of a case of erythema multiforme-like eruption due to the use of rubber gloves. After several complementary studies, including epicutaneous and skin prick tests, we concluded that the eruption was secondary to sensitization to carbamates and thiuram. The main differential diagnosis in this case was allergic contact dermatitis to latex in natural rubber gloves. This entity is less frequent than might be expected, because it is usually due to intermediate chemical compounds used in rubber manufacturing, such as vulcanization accelerators; among of these latter compounds are thiurams and carbamates. Erythema multiforme-like eruption is a rare manifestation of contact dermatitis. Several cases have been reported, most of which have been due to contact with plants, metals or topical non-steroidal anti-inflammatory drugs. Its mechanism is still unclear, but it seems to be a type IV hypersensitivity reaction.
authors.affiliation: Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. vmld_2000@yahoo.es
authors.forename: Vicente M
authors.initials: VM
authors.lastname: Leis-Dosil
authors.forename: Minia
authors.initials: M
authors.lastname: Campos-Domínguez
authors.forename: Pamela E
authors.initials: PE
authors.lastname: Zamberk-Majlis
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Suárez-Fernández
authors.forename: Pablo
authors.initials: P
authors.lastname: Lázaro-Ochaita
mesh_terms: D000328:Adult; D002219:Carbamates / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D004892:Erythema Multiforme / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D017575:Gloves, Protective / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology*; D007073:Immunoglobulin E / Q000276:immunology; D020315:Latex Hypersensitivity / Q000175:diagnosis*; D010328:Patch Tests; D013893:Thiram / Q000009:adverse effects*
chemical_list: D002219:Carbamates; D013893:Thiram; D007073:Immunoglobulin E