Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy.
OBJECTIVE
To use intravenous adenosine as a rescue therapy for neonatal refractory pulmonary hypertension in a low-weight premature infant. STUDY LINE: We report the successful use of a continuous intravenous adenosine infusion in a 1150-g premature baby with severe persistent pulmonary hypertension, refractory to classic management with high-frequency oscillatory ventilation, oxygen therapy and inhaled nitric oxide.


RESULTS
Adenosine infusion had a dramatic effect allowing for a rapid weaning of oxygen, ventilatory variables, and nitric oxide.


CONCLUSIONS
Although experience with continuous adenosine infusion is still at an early stage, it might be worth considering its administration as a rescue therapy or even as an alternative to extracorporeal membrane oxygenation.
Motti
Alessandro
A
Service of Pediatric and Neonatal Intensive Care, Department of Pediatrics, Geneva Children's University Hospital, Switzerland.
Tissot
Cécile
C
Rimensberger
Peter C
PC
Prina-Rousso
Aline
A
Aggoun
Yacine
Y
Berner
Michel
M
Beghetti
Maurice
M
da Cruz
Eduardo
E
D000241:Adenosine / Q000627:therapeutic use*; D006612:High-Frequency Ventilation; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007262:Infusions, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use; D010547:Persistent Fetal Circulation Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D017211:Treatment Failure; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009569:Nitric Oxide; D000241:Adenosine