Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin.
Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.
English
B Keith
BK
Department of Pediatrics, University of Tennessee Health Science Center, 38103, USA. kenglish@utmem.edu
Maryniw
Erik M
EM
Talati
Ajay J
AJ
Meals
Elizabeth A
EA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D015169:Colony Count, Microbial / Q000706:statistics & numerical data; D017576:Daptomycin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016106:Methicillin Resistance; D051379:Mice; D008826:Microbial Sensitivity Tests; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis; D010068:Oxacillin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014640:Vancomycin / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha; D014640:Vancomycin; D052247:Nitric Oxide Synthase Type II; D017576:Daptomycin; D010068:Oxacillin