In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone.
DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.
Park
Hee-Soo
HS
School of Life and Food Sciences, Handong Global University, Kyungbuk, Republic of Korea.
Kim
Hyun-Joo
HJ
Seol
Min-Jung
MJ
Choi
Dong-Rack
DR
Choi
Eung-Chil
EC
Kwak
Jin-Hwan
JH
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C480202:zabofloxacin