Dystrophic calcification as a cause for non healing leg ulcers.
Despite advances in molecular biology and a repertoire of other therapeutic options, chronic venous leg ulcers remain a significant problem within our society. There are various reasons, both local and systemic, which contribute to the non healing nature of such wounds. Among them, dystrophic calcification (DC) or calcified deposits within the ulcer bed, although rare, is an overlooked and a seldom reported cause. In the presence of DC, wound healing cannot proceed through a timely and orderly manner resulting in a non healing ulcer. In this article, we discuss the aetiology, pathophysiology and the management options of this rarely reported condition. We also report their clinical prognosis using a series of patients with venous ulcers complicated by DC leading to difficulties in healing.
Enoch
Stuart
S
Wound Healing Research Unit, Cardiff University, Medicentre, Cardiff, UK.
Kupitz
Susanne
S
Miller
David R
DR
Harding
Keith G
KG
D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D014647:Varicose Ulcer / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D014945:Wound Healing / Q000502:physiology*