A study on the perturbation of model lipid membranes by phenoxazines.
The interactions of six newly synthesized phenoxazine derivatives with lipid bilayers were studied by means of calorimetry, fluorescence spectroscopic methods and electron spin resonance. Depending on their structure studied compounds decreased membrane fluidity and increased lipid order in liquid-crystalline bilayers to different degrees. These studies showed also that phenoxazine molecules are located close to the polar/apolar interface of bilayer. The results allow to conclude that phenoxazines rather weakly interact with lipid bilayers.
Hendrich
Andrzej B
AB
Department of Biophysics, Wrocław Medical University, Wrocław, Poland. hendrich@biofiz.am.wroc.pl
Stańczak
Kamila
K
Komorowska
Małgorzata
M
Motohashi
Noboru
N
Kawase
Masami
M
Michalak
Krystyna
K
D004578:Electron Spin Resonance Spectroscopy; D005452:Fluoresceins / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013696:Temperature
D005452:Fluoresceins; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010078:Oxazines; C039203:phenoxazine; C007740:fluorexon