title: Palliative stent implantation in the treatment of malignant colorectal obstruction.
abstract: BACKGROUND
  Palliative surgical interventions for the management of colonic obstruction in cases of metastasized or locally irresectable colorectal carcinoma show remarkable morbidity and mortality rates for mostly older and multimorbid patients. For manifest obstruction, placement of a self-expanding metal stent (SEMS) is considered to be a suitable minimally invasive therapeutic option. This study aimed to investigate the efficacy of stent-based treatment for malignant large bowel obstruction.
  
  
  METHODS
  From January 1999 to June 2005, consecutive patients who had undergone placement of a SEMS for malignant colorectal obstruction were enrolled and monitored. Manifest incontinence and rectum carcinoma within 5 cm above the anocutaneous line were contraindications for SEMS implantation. For all further locations of tumor-induced stenosis, a stent was implanted using endoscopy and fluoroscopy. This case series was characterized in terms of age, carcinoma localization, complications, morbidity and mortality, and the necessity for further interventions.
  
  
  RESULTS
  For 44 of 48 patients (92%), stents were placed successfully and obstruction was abolished. The four remaining patients experienced stent dislocation. The median of age of the patients was 77.7 years (range, 47-96 years). The distribution of malignant stenoses was as follows: rectum (n = 16, 33.3%), sigmoideal colon (n = 21, 43.8%), descending colon (n = 4, 8.3%), splenic flexure (n = 2, 4.2%), transversal colon (n = 3, 6.2%), hepatic flexure (n = 1, 2.1%), and ascending colon (n = 1, 2.1%). There was no peri-interventional morbidity or mortality. The median in situ time for the stents was 251 days (mean, 422 days), with 13 of 44 patients treated with palliative therapy showing complications (29.5%). Six patients were treated endoscopically, and three individuals underwent surgical intervention. For four patients, no further intervention was required. Overall, there was no treatment-related mortality.
  
  
  CONCLUSIONS
  For palliative treatment of malignancy-induced colorectal obstruction, SEMS is an efficient tool associated with low morbidity and minimal mortality. From a technical point of view, all tumor locations are accessible.
authors.affiliation: Department of Surgery, Carl-Thiem Hospital Cottbus, Theimstr. 111, Cottbus, D-03048, Germany. henry.ptok@medizin.uni-magdeburg.de
authors.forename: H
authors.initials: H
authors.lastname: Ptok
authors.forename: F
authors.initials: F
authors.lastname: Meyer
authors.forename: F
authors.initials: F
authors.lastname: Marusch
authors.forename: R
authors.initials: R
authors.lastname: Steinert
authors.forename: I
authors.initials: I
authors.lastname: Gastinger
authors.forename: H
authors.initials: H
authors.lastname: Lippert
authors.forename: L
authors.initials: L
authors.lastname: Meyer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome