TFIIIC boxes in the genome.
In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a barrier throughout the genome.
Wallrath
Lori L
LL
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Geyer
Pamela K
PK
D001665:Binding Sites / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D004258:DNA Polymerase III / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D016681:Genome, Fungal / Q000235:genetics*; D006570:Heterochromatin / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics; D000098832:Transcription Factor TFIIIC
D004268:DNA-Binding Proteins; D006570:Heterochromatin; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D004258:DNA Polymerase III