title: Impact of no-to-moderate mitral regurgitation on late results after isolated coronary artery bypass grafting in patients with ischemic cardiomyopathy.
abstract: BACKGROUND
  This study analyzes retrospectively a cohort of patients with ischemic cardiomyopathy (ejection fraction < or = 0.30) who underwent isolated coronary artery bypass grafting to evaluate the impact of no-to-moderate mitral regurgitation (MR) on long-term results.
  
  
  METHODS
  From January 1988 to December 2002, 6,108 patients had isolated coronary artery bypass grafting. Two hundred thirty-nine (3.9%) had ischemic cardiomyopathy; 60 patients had no, 102 had mild, and 77 had moderate MR. Using propensity score, a group of 70 patients with no or mild MR (group A) was case-matched with a group of 70 patients with moderate MR (group B) to obtain two groups with similar preoperative characteristics.
  
  
  RESULTS
  Nine patients (6.4%) died within the first 30 days; all deaths were cardiac-related. There was no difference in the early results between groups. Patients in group B showed lower freedom from death, from cardiac death, from cardiac death and ischemic events, and from death and New York Heart Association class III and IV than patients in group A. Cox analysis confirmed that moderate MR was an independent variable for worse late outcome in this subgroup of patients. Functional and echocardiographic results, after a mean of 62 +/- 28 months in 87.8% of survivors, showed a significant impairment of New York Heart Association class (from 2.2 +/- 0.5 to 2.8 +/- 0.6; p < 0.001) and MR degree (from 2.0 to 2.7 +/- 1.0; p = 0.023) in patients with preoperative moderate MR.
  
  
  CONCLUSIONS
  This study confirms that moderate ischemic MR has an important negative impact on survival and quality of life of patients with severely impaired left ventricular function, treated by coronary artery bypass grafting alone.
authors.affiliation: Division of Cardiac Surgery, University G. D'Annunzio, Chieti, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Di Mauro
authors.forename: Gabriele
authors.initials: G
authors.lastname: Di Giammarco
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vitolla
authors.forename: Marco
authors.initials: M
authors.lastname: Contini
authors.forename: Angela L
authors.initials: AL
authors.lastname: Iacò
authors.forename: Antonio
authors.initials: A
authors.lastname: Bivona
authors.forename: Luca
authors.initials: L
authors.lastname: Weltert
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Calafiore
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data*; D047549:Coronary Artery Bypass, Off-Pump; D003643:Death; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging; D009203:Myocardial Infarction / Q000150:complications / Q000453:epidemiology / Q000601:surgery; D017202:Myocardial Ischemia / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D016016:Proportional Hazards Models; D011788:Quality of Life; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology; D016019:Survival Analysis; D016896:Treatment Outcome; D014463:Ultrasonography