title: Phenolic compounds from the roots of Lindera fruticosa.
abstract: The phenolic compounds isolated from the roots of Lindera fruticosa included four new compounds, 2-methoxy-3,4-methylenedioxybenzophenone (1), (S)-2-methoxy-3,4-methylenedioxybenzhydryl alcohol (2), 3-hydroxy-5-methoxybiphenyl (3), and 1-methoxy-2,5,7-trihydroxyxanthone (4). Three previously identified phenolics were also identified, namely, 3,5-dimethoxybiphenyl (5), benzyl 2-hydroxy-6-methoxybenzoate (6), and 1,7-dihydroxyxanthone (7). These compounds were evaluated for their inhibitory effects on human acyl-CoA:cholesterol acyltransferase activity and on the in vitro oxidation of low-density lipoprotein.
authors.affiliation: Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon 449-701, Korea.
authors.forename: Myoung-Chong
authors.initials: MC
authors.lastname: Song
authors.forename: Fikru
authors.initials: F
authors.lastname: Nigussie
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Chang-Yong
authors.initials: CY
authors.lastname: Lee
authors.forename: Fekadu
authors.initials: F
authors.lastname: Regassa
authors.forename: Takele
authors.initials: T
authors.lastname: Markos
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005002:Ethiopia; D006801:Humans; D027443:Lindera / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000187:drug effects*; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D008077:Lipoproteins, LDL; D010636:Phenols; D002785:Sterol O-Acyltransferase