title: [Detection of acute HIV infection by serum HIV-1 RNA quantification].
abstract: To assess the merit of serum HIV-1 RNA quantification in detecting acute HIV infection, we reviewed the results of HIV-1 RNA assay and antibody tests in all patients who received those tests at our hospital from August 1999 to December 2004. Of 3530 such patients, five were sero-negative and PCR-positive with more than 105 copies/ml at initial examination. Four of them had HAART and followed a favorable course; they were later confirmed to be sero-positive by Western blotting. The other one, positive only by CLEIA, was lost to follow-up. This reconfirms the importance of using PCR in the initial assessment of HIV infection in high-risk patients.
authors.affiliation: Department of Laboratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Bunkyo-ku, Tokyo 113-8677.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Negishi
authors.forename: Minori
authors.initials: M
authors.lastname: Shitara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Atushi
authors.initials: A
authors.lastname: Ajisawa
authors.forename: Taminori
authors.initials: T
authors.lastname: Obayashi
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood*
chemical_list: D012367:RNA, Viral