8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs).
A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs.
Zeng
He-Ping
HP
Institute of Functional Molecule, School of Chemistry, South China University of Technology, Guangzhou, China. zenghp@scnu.edu.cn
Wang
Ting-Ting
TT
Ouyang
Xin-Hua
XH
Zhou
Ya-Dong
YD
Jing
Hui-Lian
HL
Yuan
Guo-Zan
GZ
Chen
Dong-Feng
DF
Du
Shao-Hui
SH
Li
Hui
H
Zhou
Jian-Hong
JH
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D005434:Flow Cytometry; D007118:Immunoassay; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D015125:Oxyquinoline