title: Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis.
abstract: This report describes the isolation and characterization of kalanchosine dimalate (KMC), an anti-inflammatory salt from the fresh juice of the aerial parts of Kalanchoe brasiliensis. KMC comprises the new metabolite kalanchosine (1) and malic acid (2) in a 1:2 stoichiometric ratio. Kalanchosine (1), 3,6-diamino-4,5-dihydroxyoctanedioic acid, is the first naturally occurring dimeric bis(gamma-hydroxy-beta-amino acid) and is at least partially responsible for the anti-inflammatory properties of K. brasiliensis.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21 941-590 Rio de Janeiro, RJ, Brazil. sscosta@nppn.ufrj.br
authors.forename: Sônia Soares
authors.initials: SS
authors.lastname: Costa
authors.forename: Maria de Lourdes Mendes
authors.initials: Mde L
authors.lastname: de Souza
authors.forename: Tereza
authors.initials: T
authors.lastname: Ibrahim
authors.forename: Giany Oliveira
authors.initials: GO
authors.lastname: de Melo
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: de Almeida
authors.forename: Catherine
authors.initials: C
authors.lastname: Guette
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Férézou
authors.forename: Vera Lucia G
authors.initials: VL
authors.lastname: Koatz
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D031962:Kalanchoe / Q000737:chemistry*; D008293:Malates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008293:Malates; C511573:kalanchosine dimalate; C030298:malic acid