title: [Cell therapy in dilated cardiomyopathy].
abstract: A forty-one-year-old male with systolic heart failure, FC-III NYHA, clinical stage C due to dilated cardiomyopathy was submitted to an autologous transplant of the mononuclear fraction of bone marrow via coronary artery system through heart catheterism. Two months after the procedure, there was a decrease in plasma BNP and cardiac area reduction at the thorax X-ray and nuclear magnetic resonance. The echocardiogram showed decrease of the secondary regurgitation and mitral ring dilatation. There was a better performance at the ergospirometry, with increase of the maximum oxygen consumption and consequent reduction in drug therapy. The absence of adverse events characterized by clinical/hemodynamic instability, enzymatic alteration or electrocardiogram demonstrate the safety and feasibility of this procedure carried out and described with pioneering spirit in dilated cardiomyopathy.
authors.affiliation: Hospital Prócardíaco, Instituto Nacional de Cardiologia Laranjeiras, Rio de Janeiro, RJ. hmartino@cardiol.br
authors.forename: Helena Furtado
authors.initials: HF
authors.lastname: Martino
authors.forename: Paulo Sérgio
authors.initials: PS
authors.lastname: Oliveira
authors.forename: Edmilson
authors.initials: E
authors.lastname: Assunção
authors.forename: Rita
authors.initials: R
authors.lastname: Villela
authors.forename: Miriam
authors.initials: M
authors.lastname: Gaze
authors.forename: Patrícia C dos Santos
authors.initials: PC
authors.lastname: Costa
authors.forename: Fernando César Castro
authors.initials: FC
authors.lastname: Souza
authors.forename: Luiz Henrique
authors.initials: LH
authors.lastname: Weitzel
authors.forename: Ana Paula R
authors.initials: AP
authors.lastname: Velloso
authors.forename: Amarino
authors.initials: A
authors.lastname: Oliveira Júnior
authors.forename: Antônio C Campos
authors.initials: AC
authors.lastname: de Carvalho
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002303:Cardiac Output, Low / Q000209:etiology; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000601:surgery*; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood
chemical_list: D020097:Natriuretic Peptide, Brain