title: An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma.
abstract: The case of a 50-year-old woman with cerebral meningioma and concomitant parathyroid adenoma and papillary thyroid carcinoma is presented. She complained of neurological symptoms characterized by right hemiparesis and dysarthria. Cerebral CT and MRI scans revealed a left voluminous frontal parasagittal lesion with the characteristics of a meningioma. Routine laboratory analysis revealed altered values of calcium-phosphorus metabolism. Intravenous infusion of saline solution at 0.9% of NaCl resulted in a reduction of serum ionized calcium. A left craniotomy was performed and a fibroblastic meningioma of 5 cm in diameter was removed. Even though the patient's clinical condition was good, a calcium-phosphorus metabolism test confirmed high plasma levels of ionized calcium and parathyroid hormone. Thyroid and parathyroid ultrasonography revealed multinodular goiter and a parathyroid lesion confirmed by 99mTc-TCO4 / 99mTc-MIBI scintigraphy. A left superior parathyroidectomy and total thyroidectomy were performed. Histological examination revealed a parathyroid adenoma and a small papillary carcinoma of 0.4 cm in the right thyroid lobe. As far as we know, this patient is the third case of meningioma associated with parathyroid adenoma and papillary thyroid carcinoma described in the literature.
authors.affiliation: Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Caliumi
authors.forename: Dario
authors.initials: D
authors.lastname: Cotesta
authors.forename: Luigi
authors.initials: L
authors.lastname: Petramala
authors.forename: Monica
authors.initials: M
authors.lastname: Lorio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Salvati
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Filetti
authors.forename: Giorgio
authors.initials: G
authors.lastname: De Toma
authors.forename: Emilio
authors.initials: E
authors.lastname: D'Erasmo
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis*; D002291:Carcinoma, Papillary / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008579:Meningioma / Q000175:diagnosis*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D010282:Parathyroid Neoplasms / Q000175:diagnosis*; D013964:Thyroid Neoplasms / Q000175:diagnosis*