Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.
Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain-containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3.1, 95% confidence intervals (CI) 1.1-8.8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility.
Forrest
Matthew S
MS
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
Skibola
Christine F
CF
Lightfoot
Tracy J
TJ
Bracci
Paige M
PM
Willett
Eleanor V
EV
Smith
Martyn T
MT
Holly
Elizabeth A
EA
Roman
Eve
E
D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology; D009363:Neoplasm Proteins / Q000235:genetics; D053473:Nod2 Signaling Adaptor Protein; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics
D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D009363:Neoplasm Proteins; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4