The therapeutic potential of TREM-1 modulation in the treatment of sepsis and beyond.
The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and the inflammatory response. It belongs to a family related to natural killer cell receptors, and is expressed on neutrophils, mature monocytes and macrophages. The engagement of TREM-1 synergizes with the activation of several toll-like receptors in amplifying the inflammatory response mediated by microbial components. The modulation of the TREM-1 signaling pathway, by the use of small synthetic peptides derived from its extracellular domain, confers interesting survival advantages during experimental murine septic shock, even when administered late after the onset of sepsis.
Gibot
Sébastien
S
Service de Réanimation Médicale Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France. s.gibot@chu-nancy.fr
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D022801:Complementarity Determining Regions / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D010449:Peptide Mapping; D011487:Protein Conformation; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D018805:Sepsis / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D000893:Anti-Inflammatory Agents; D022801:Complementarity Determining Regions; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1