Germline BCL-2 sequence variants and inherited predisposition to prostate cancer.
Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.
Kidd
L R
LR
Cancer Prevention and Control Program, Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Coulibaly
A
A
Templeton
T M
TM
Chen
W
W
Long
L O
LO
Mason
T
T
Bonilla
C
C
Akereyeni
F
F
Freeman
V
V
Isaacs
W
W
Ahaghotu
C
C
Kittles
R A
RA
D000328:Adult; D001741:Black or African American / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D018095:Germ-Line Mutation; D006239:Haplotypes; D006801:Humans; D040582:Inheritance Patterns; D007563:Jamaica / Q000208:ethnology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D016366:Open Reading Frames; D011471:Prostatic Neoplasms / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D050436:Regulatory Elements, Transcriptional; D044465:White People / Q000235:genetics
D019253:Proto-Oncogene Proteins c-bcl-2