title: Transcervical intrapartum amnioinfusion for preterm premature rupture of the membranes.
abstract: OBJECTIVE
  To investigate the effect of transcervical amnioinfusion on the management of labour and neonatal outcomes in preterm premature rupture of the membranes.
  
  
  METHODS
  This clinical trial included 86 patients with premature rupture of the membranes between weeks 27 and 35 of gestation. Patients were randomly assigned to receive amnioinfusion via a two-way catheter or to the control group. Clinical management was otherwise the same in both groups.
  
  
  RESULTS
  Amnioinfusion decreased the frequency of variable decelerations in fetal heart rate (27.9% versus 53.5%, p<0.05) and the rate of obstetric interventions motivated by nonreassuring fetal status (13.6% versus 52.4%, p<0.05). At delivery, pH values were significantly higher in the treatment group than in the conventionally managed control group (median 7.29 versus 7.27).
  
  
  CONCLUSIONS
  Intrapartum transcervical amnioinfusion for preterm premature rupture of the membranes reduced the number of interventions needed because of nonreassuring fetal status, and improved neonatal gasometric values without increasing maternal or fetal morbidity.
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain. Electronic address: albertom.puertas.sspa@juntadeandalucia.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Puertas
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Tirado
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Pérez
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: María S
authors.initials: MS
authors.lastname: López
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Montoya
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Cañizares
authors.affiliation: Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Miranda
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000328:Adult; D000650:Amnion / Q000503:physiopathology; D000653:Amniotic Fluid / Q000502:physiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology / Q000628:therapy*; D005333:Fetus / Q000502:physiology; D006340:Heart Rate, Fetal / Q000502:physiology; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods*; D007752:Obstetric Labor, Premature / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000502:physiology; D011263:Pregnancy Trimester, Third / Q000502:physiology