Brain tumour stem cells.
The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
Vescovi
Angelo L
AL
Department of Biotechnology and Biosciences, University of Milan Bicocca, Milan 20126, Italy. vescovi@tin.it
Galli
Rossella
R
Reynolds
Brent A
BA
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology*; D009474:Neurons / Q000378:metabolism