title: Activities and accomplishments of the cancer and leukemia group B genitourinary committee.
abstract: The Cancer and Leukemia Group B Genitourinary (GU) Committee has developed a multidisciplinary approach to treatment of GU cancer and has integrated correlative science research into the major research themes of the GU Committee. In localized prostate cancer, trials have evaluated novel approaches in radiation therapy. For patients with recurrence after local therapy, a trial evaluating local recurrence with salvage prostatectomy and a study of systemic therapy with "peripheral androgen blockade" were undertaken. Major contributions have been made in developing and testing therapeutics for advanced, androgen-independent prostate cancer (ketoconazole, suramin, estramustine/docetaxel, and docetaxel/bevacizumab), and in developing predictive markers and algorithms to assess prognosis in these patients. Contributions in kidney cancer have included the development of novel trial methodology, such as the randomized discontinuation trial design, and the testing of antiangiogenics. In addition to these areas, future work of the committee will include further development of therapy for earlier-stage prostate cancer patients and bladder cancer patients.
authors.affiliation: University of California/San Francisco, San Francisco, California, USA. smalle@medicine.ucsf.edu
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Small
authors.forename: Susan
authors.initials: S
authors.lastname: Halabi
authors.forename: Phillip
authors.initials: P
authors.lastname: Kantoff
authors.forename: Anthony
authors.initials: A
authors.lastname: D'Amico
authors.forename: Walter
authors.initials: W
authors.lastname: Stadler
authors.forename: W Kevin
authors.initials: WK
authors.lastname: Kelley
authors.forename: James
authors.initials: J
authors.lastname: Mohler
authors.forename: Dean
authors.initials: D
authors.lastname: Bajorin
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Vogelzang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy; D007938:Leukemia / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000628:therapy; D011471:Prostatic Neoplasms / Q000628:therapy; D011878:Radiotherapy; D012955:Societies, Medical; D001749:Urinary Bladder Neoplasms / Q000628:therapy; D014565:Urogenital Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents