title: Profound lymphopenia and bacteraemia.
abstract: Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.
authors.affiliation: Department of Clinical Immunology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia. carolyn.hawkins@act.gov.au
authors.forename: C A
authors.initials: CA
authors.lastname: Hawkins
authors.forename: P
authors.initials: P
authors.lastname: Collignon
authors.forename: D N
authors.initials: DN
authors.lastname: Adams
authors.forename: F J
authors.initials: FJ
authors.lastname: Bowden
authors.forename: M C
authors.initials: MC
authors.lastname: Cook
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology*; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents