Rgs 2 gene polymorphisms as modulators of anxiety in humans?
Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
Leygraf
A
A
Laboratory of Molecular Psychiatry, Department of Psychiatry, University of Münster, Münster, Germany.
Hohoff
C
C
Freitag
C
C
Willis-Owen
S A G
SA
Krakowitzky
P
P
Fritze
J
J
Franke
P
P
Bandelow
B
B
Fimmers
R
R
Flint
J
J
Deckert
J
J
D000379:Agoraphobia / Q000150:complications / Q000235:genetics / Q000523:psychology; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D017931:DNA Primers; D006801:Humans; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D016584:Panic Disorder / Q000235:genetics / Q000523:psychology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D020710:RGS Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D020710:RGS Proteins; C087182:RGS2 protein, human