title: Stem cell transplantation for polycythemia vera.
abstract: Polycythemia vera (PV) is a rare disease in children. A 9-year-old male was diagnosed following laboratory results acquired because of an acute appendicitis. Regular phlebotomy was performed for over 2 years followed by alpha-interferon treatment. At the age of 12 years, HLA-matched unrelated stem cell transplantation including T-cell depletion was done. The conditioning regimen consisted of busulfan, cyclophosphamide, and ATG. Chimerism was monitored during the whole post-transplant period. A single dose of donor T-lymphocytes was given at month 3. One year after transplantation, chimerism was complete. The patient is in complete remission and shows no signs of transplant-related morbidity at month 78.
authors.affiliation: Pediatric Hematology and Oncology, University Hospital, Homburg/Saar, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Reinhard
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.forename: Peter
authors.initials: P
authors.lastname: Lang
authors.forename: Peter
authors.initials: P
authors.lastname: Bader
authors.forename: Dietrich
authors.initials: D
authors.lastname: Niethammer
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D011087:Polycythemia Vera / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous