Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis.
The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.
Kobayashi
Hideaki
H
Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hata
Harumi
H
Ujike
Hiroshi
H
Harano
Mutsuo
M
Inada
Toshiya
T
Komiyama
Tokutaro
T
Yamada
Mitsuhiko
M
Sekine
Yoshimoto
Y
Iwata
Nakao
N
Iyo
Masaomi
M
Ozaki
Norio
N
Itokawa
Masanari
M
Naka
Maki
M
Ide
Soichiro
S
Ikeda
Kazutaka
K
Numachi
Yohtaro
Y
Sora
Ichiro
I
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D017465:Receptors, Opioid, delta / Q000235:genetics*
D017465:Receptors, Opioid, delta; D008694:Methamphetamine