title: Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy.
abstract: OBJECTIVE
  To use intravenous adenosine as a rescue therapy for neonatal refractory pulmonary hypertension in a low-weight premature infant. STUDY LINE: We report the successful use of a continuous intravenous adenosine infusion in a 1150-g premature baby with severe persistent pulmonary hypertension, refractory to classic management with high-frequency oscillatory ventilation, oxygen therapy and inhaled nitric oxide.
  
  
  RESULTS
  Adenosine infusion had a dramatic effect allowing for a rapid weaning of oxygen, ventilatory variables, and nitric oxide.
  
  
  CONCLUSIONS
  Although experience with continuous adenosine infusion is still at an early stage, it might be worth considering its administration as a rescue therapy or even as an alternative to extracorporeal membrane oxygenation.
authors.affiliation: Service of Pediatric and Neonatal Intensive Care, Department of Pediatrics, Geneva Children's University Hospital, Switzerland.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Motti
authors.forename: Cécile
authors.initials: C
authors.lastname: Tissot
authors.forename: Peter C
authors.initials: PC
authors.lastname: Rimensberger
authors.forename: Aline
authors.initials: A
authors.lastname: Prina-Rousso
authors.forename: Yacine
authors.initials: Y
authors.lastname: Aggoun
authors.forename: Michel
authors.initials: M
authors.lastname: Berner
authors.forename: Maurice
authors.initials: M
authors.lastname: Beghetti
authors.forename: Eduardo
authors.initials: E
authors.lastname: da Cruz
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D006612:High-Frequency Ventilation; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007262:Infusions, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use; D010547:Persistent Fetal Circulation Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D017211:Treatment Failure; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D000241:Adenosine