title: Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.
abstract: Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported.
authors.affiliation: GlaxoSmithKline Psychiatry Centre of Excellence for Drug Discovery, Via Fleming, 4, 37135 Verona, Italy. fm20244@gsk.com
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Micheli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pasquarello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tedesco
authors.forename: Dieter
authors.initials: D
authors.lastname: Hamprecht
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bonanomi
authors.forename: Anna
authors.initials: A
authors.lastname: Checchia
authors.forename: Albert
authors.initials: A
authors.lastname: Jaxa-Chamiec
authors.forename: Federica
authors.initials: F
authors.lastname: Damiani
authors.forename: Silvia
authors.initials: S
authors.lastname: Davalli
authors.forename: Daniele
authors.initials: D
authors.lastname: Donati
authors.forename: Chiara
authors.initials: C
authors.lastname: Gallotti
authors.forename: Marcella
authors.initials: M
authors.lastname: Petrone
authors.forename: Marilisa
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Graham
authors.initials: G
authors.lastname: Riley
authors.forename: Silvia
authors.initials: S
authors.lastname: Terreni
authors.forename: Martyn
authors.initials: M
authors.lastname: Wood
mesh_terms: D008958:Models, Molecular; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D058830:Serotonin 5-HT2 Receptor Antagonists; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D011758:Pyrroles; D011760:Pyrrolidinones; D058830:Serotonin 5-HT2 Receptor Antagonists; D012702:Serotonin Antagonists