Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.
Varaprasad
Chamakura V N S
CV
Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com
Barawkar
Dinesh
D
El Abdellaoui
Hassan
H
Chakravarty
Subrata
S
Allan
Matthew
M
Chen
Huanming
H
Zhang
Weijian
W
Wu
Jim Z
JZ
Tam
Robert
R
Hamatake
Robert
R
Lang
Stanley
S
Hong
Zhi
Z
D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D048369:MAP Kinase Kinase 1 / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D013844:Thiazoles; D048369:MAP Kinase Kinase 1