title: Hydrodynamic evaluation of kangaroo aortic valve matrices for tissue valve engineering.
abstract: We evaluated the hydrodynamic performance of kangaroo aortic valve matrices (KMs) (19, 21, and 23 mm), as potential scaffolds in tissue valve engineering using a pulsatile left heart model at low and high cardiac outputs (COs) and heart rates (HRs) of 60 and 90 beats/min. Data were measured in two samples of each type, pooled in two CO levels (2.1 +/- 0.7 and 4.2 +/- 0.6 L/min; mean +/- standard errors on the mean), and analyzed using analysis of variance with CO level, HR, and valve type as fixed factors and compared to similar porcine matrices (PMs). Transvalvular pressure gradient (DeltaP) was a function of HR (P < 0.001) and CO (P < 0.001) but not of valve type (P = 0.39). DeltaP was consistently lower in KMs but not significantly different from PMs. The effective orifice area and performance index of kangaroo matrices was statistically larger for all sizes at both COs and HRs.
authors.affiliation: Department of Cardiac Surgery, University Hospital Ghent, Ghent, Belgium. kishan.narine@ugent.be
authors.forename: Kishan K
authors.initials: KK
authors.lastname: Narine
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kramm
authors.forename: Kris
authors.initials: K
authors.lastname: Dumont
authors.forename: Homayoun
authors.initials: H
authors.lastname: Jalali
authors.forename: Lisa
authors.initials: L
authors.lastname: Sparks
authors.forename: Patrick
authors.initials: P
authors.lastname: Segers
authors.forename: Pascal
authors.initials: P
authors.lastname: Verdonck
authors.forename: Guido J
authors.initials: GJ
authors.lastname: Van Nooten
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000502:physiology*; D001705:Bioprosthesis; D002302:Cardiac Output; D006339:Heart Rate; D006350:Heart Valve Prosthesis; D007614:Macropodidae; D011673:Pulsatile Flow; D013552:Swine; D023822:Tissue Engineering / Q000379:methods*