title: Does instant coffee prevent acute liver injury induced by carbon tetrachloride (CCl(4))?
abstract: OBJECTIVE
  To investigate the protective effect of instant coffee (IC) on acute liver injury induced by CCl(4).
  
  
  METHODS
  The study included 32 rats which were allocated to four groups: control (n: 8), CCl(4) (n: 8), CCl(4)+IC (n: 8) and IC (n: 8). Malondialdehyde, which is a lipid peroxidation product, and levels of antioxidant capacity were measured and histopathological data were compared.
  
  
  RESULTS
  It was seen in the study that lipid peroxidation products that increased in the plasma and liver tissue of the CCl(4) group decreased by IC administration. There was an increase in the measured antioxidant parameters, which were total antioxidant capacity (TAOC), sulphydryl (SH) and ceruloplasmin levels. Histopathologically, it was found that inflammation and necrosis which increased in the group administered CCl(4) decreased significantly with IC administration, but there steatosis did not change.
  
  
  CONCLUSIONS
  It was seen that IC had a protective role in acute liver injury induced by CCl(4), but did not affect steatosis.
authors.affiliation: Fırat University, Faculty of Medicine, Department of Pathology, 23119 Elazig, Turkey.
authors.forename: Ibrahim Hanifi
authors.initials: IH
authors.lastname: Ozercan
authors.forename: Adile Ferda
authors.initials: AF
authors.lastname: Dagli
authors.forename: Bilal
authors.initials: B
authors.lastname: Ustundag
authors.forename: Mehmet Resat
authors.initials: MR
authors.lastname: Ozercan
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Bahcecioglu
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalniz
authors.forename: Orhan Kursat
authors.initials: OK
authors.lastname: Poyrazoglu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ataseven