title: [Acromegaly: multifaceted clinical presentation of a rare disease of the elderly. Report of two cases with long-term follow-up].
abstract: We report two cases of acromegaly in elderly patients. Both patients had markedly invasive GH-secreting macroadenomas, which caused hugely increased circulating GH levels (over 90 ng/ml). The first patient, 79 year-old, presented with goitre and severe osteoarthrosis, refused surgery and was treated with various somatostatin analogues (ultimately accompanied by cabergoline), without satisfactory control of the disease. The second patient, 67-year-old, presented with symptoms secondary to hypopituitarism, which had been previously misdiagnosed. These symptoms resolved with the appropriate substitutive therapy, which led to a significant improvement in her condition. However, two transphenoidal operations, radiotherapy and long-term somatostatin agonist therapy were required to control GH hypersecretion satisfactorily. The authors wish to underline that acromegaly is a rare but not negligible disorder in the elderly, which can affect the whole body functions and cause severe morbidities. In the two cases presented somatostatin agonists alone were not able to control the tumoral hypersecretion adequately. The prompt discovery (usually through a simple clinical evaluation) of this disease in the elderly, confirmed by hormonal and morphological evaluation, together with a multidisciplinary (medical, surgical, radiotherapeutic) approach can improve their quality of life and increase life expectancy.
authors.affiliation: Struttura Complessa di Endocrinologia, Ente Ospedaliero Ospedali Galliera, Genova. luca.foppiani@galliera.it
authors.forename: Luca
authors.initials: L
authors.lastname: Foppiani
authors.forename: Patrizia
authors.initials: P
authors.lastname: Del Monte
authors.forename: Antonio
authors.initials: A
authors.lastname: Ruelle
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marugo
authors.forename: Donatella
authors.initials: D
authors.lastname: Bernasconi
mesh_terms: D000172:Acromegaly / Q000209:etiology* / Q000628:therapy; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013004:Somatostatin / Q000819:agonists; D016896:Treatment Outcome
chemical_list: D013004:Somatostatin