Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii.
A phytochemical investigation of the constituents of the roots of Vismia laurentii has resulted in the isolation of two xanthone derivatives named laurentixanthone A (1) (6-hydroxy-3,3-dimethyl-11-(3-methylbut-2-enyl)pyrano[2,3-c]xanthen-7(3H)-one) and laurentixanthone B (2) (1-hydroxy-5,6,7,8-tetramethoxyxanthone), along with 11 known compounds: 1,7-dihydroxyxanthone, vismiaquinone, vismiaquinone B, bivismiaquinone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone, O(1)-demethyl-3',4'-deoxypsorospermin-3',4'-diol, 6-deoxyisojacareubin, 1,8-dihydroxy-6-methoxy-3-methylanthraquinone, kaempferol, friedelin and stigmasterol. The structures of compounds were established by means of spectroscopic methods. Furthermore, the compounds were screened for antimicrobial activities in vitro.
Nguemeving
Jean Robert
JR
Department of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Azebaze
Anatole Guy Blaise
AG
Kuete
Victor
V
Eric Carly
Nono Nono
NN
Beng
Véronique Penlap
VP
Meyer
Michèle
M
Blond
Alain
A
Bodo
Bernard
B
Nkengfack
Augustin Ephrem
AE
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D014966:Xanthenes; D044004:Xanthones; C514269:laurentixanthone A; C514270:laurentixanthone B