[Secretion and expression of E-selectin in nasal polyps].
OBJECTIVE
To investigate the significance of E-selectin in nasal polyps.


METHODS
The E-selectin was measured by enzyme linked immunosorbent assay in 25 patients and 9 control cases from polyp tissue and normal inferior turbinates respectively. Meanwhile, the expression of E-selectin in these samples was studied with immunohistochemistry. All these samples were also studied by HE stain and observed under optical microscope.


RESULTS
Plentiful eosinophils infiltrated the matrix were observed in nasal polyps group. The level of E-selectin was(42.58 +/- 13.52) microg/L,significantly higer than that of controls (11.35 +/- 3.17) microg/L, (P < 0.001). E-selectin express mainly in the vascular endothelial, the gland cells and the extracellular matrix with infiltrated inflammation cells of nasal polyps. The expressions in the vascular endothelial and the matrix of nasal polyps were significantly higher than those of inferior turbinates (84.0% and 92.0%, P = 0.05, 0.01, respectively). The statistical analysis showed there was positive correlation between the expression of E-selectin in the vascular endothelial and in the matrix (r = 0.544, P < 0.01).


CONCLUSIONS
This study demonstrates that the secretion and expression of E-selectin in nasal polyps increase significantly. E-selectin may play a key role involving in the occurrence of nasal polyps in the chronic inflammation procedure with inflammation cells to attach to the vascular, to migrate into the matrix as well as to be activated.
Kang
Houyong
H
Department of Otorhinolaryngolgy, Ningbo First Hospital, Zhejiang Province, Ningbo, 315010, China. kanghouyong@sohu.com
Zhang
Jianhua
J
Tang
Shixiong
S
Zhu
Hualin
H
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D019040:E-Selectin / Q000096:biosynthesis* / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism*; D014420:Turbinates / Q000378:metabolism; D055815:Young Adult
D019040:E-Selectin