What is the outcome of targeted tuberculosis screening based on universal genotyping and location?
OBJECTIVE
Identifying and treating persons with latent tuberculosis (TB) infection (LTBI) at high risk for developing TB is part of the current TB elimination strategy. There are no specific criteria, other than medical risks, to designate groups as high risk for developing TB. We hypothesized that, if location-based screenings were done in communities where persons with genotypically clustered Mycobacterium tuberculosis resided, then persons with LTBI from recent transmission and with undiagnosed TB could be identified.


METHODS
Location-based TB screenings were done in partnership with multiple community-based organizations using resources previously used for other types of screening.


RESULTS
Location-based screenings identified one person with TB for every 83 screened, and one person with LTBI for every five screened. The yield of this targeted screening program for discovering persons with TB and LTBI exceeded what would be expected from nontargeted screening in a county with a TB incidence of 5.7 per 100,000 population.


CONCLUSIONS
Genotyping combined with geographic information systems analysis can potentially be used to define high-risk status and to define areas for location-based TB screenings.
Moonan
Patrick K
PK
School of Medicine, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.
Oppong
Joseph
J
Sahbazian
Behzad
B
Singh
Karan P
KP
Sandhu
Raghbir
R
Drewyer
Gerry
G
Lafon
Terry
T
Marruffo
Marco
M
Quitugua
Teresa N
TN
Wallace
Charles
C
Weis
Stephen E
SE
D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000175:diagnosis* / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D040362:Geographic Information Systems; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D013781:Texas; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology