In vitro release of elements from prosthodontic base metal alloys: effect of protein-containing biologic environments.
OBJECTIVE
This study aimed to investigate the release of nickel, copper, zinc, cadmium, magnesium, and lead from prosthodontic base metal alloys into protein-containing biologic solutions.


METHODS
Dissolution experiments were conducted in either 3% Dulbecco's Modified Eagle Medium or 3% bovine serum albumin solutions for 7 weeks.


RESULTS
The protein-containing dissolution solutions and dissolution time did not have a significant effect on release of elements from the alloys (Kruskal-Wallis, P > .05).


CONCLUSIONS
The amount of the released elements was well below the dietary intake levels of these elements. This study is important given the widespread use of the base metal alloys and the continuing public concerns/questions regarding the health benefits/risks associated with these materials.
Efeoglu
Neslihan
N
Department of Restorative Dentistry, Leeds Dental Institute, University of Leeds, United Kingdom. n.efeoglu@leeds.ac.uk
Ozturk
Berran
B
Coker
Canan
C
Cotert
Serdar
S
Bulbul
Memduh
M
D000818:Animals; D002104:Cadmium / Q000737:chemistry; D002417:Cattle; D002858:Chromium Alloys / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D003470:Culture Media; D003722:Dental Alloys / Q000737:chemistry*; D003819:Denture Bases; D007854:Lead / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012449:Safety; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012995:Solubility; D013997:Time Factors; D015032:Zinc / Q000737:chemistry
D002858:Chromium Alloys; D003470:Culture Media; D003722:Dental Alloys; D011506:Proteins; D002104:Cadmium; D012710:Serum Albumin, Bovine; D007854:Lead; D003300:Copper; D009532:Nickel; D008274:Magnesium; D015032:Zinc