Induction of protection against porcine cysticercosis in growing pigs by DNA vaccination.
A DNA vaccine, pcDNA3-B, was developed by using the nucleotide sequence of Taenia solium B antigen and cloning into pcDNA3.1 plasmid. The growing pigs were vaccinated by one intramuscular infection of 200 or 1000 microg pcDNA3-B. The immunization with 1000 microg of pcDNA3-B showed 92.6% protection when the pigs were challenged by T. solium eggs and four of the five pigs vaccinated had no viable cysts. The results provide encouraging information on the use of pcDNA3-B vaccination for the prevention of cysticercosis.
Guo
Aijiang
A
Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu 730046, China.
Jin
Zhizhong
Z
Zheng
Yadong
Y
Hai
Gang
G
Yuan
Gailing
G
Li
Hailong
H
Cai
Xuepeng
X
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D008213:Lymphocyte Activation; D051379:Mice; D013552:Swine / Q000254:growth & development; D013553:Swine Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D014335:Tropomyosin / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination / Q000662:veterinary; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D014335:Tropomyosin; D019444:Vaccines, DNA