title: Biochemical biomarkers in adult female perch (Perca fluviatilis) in a chronically polluted gradient in the Stockholm recipient (Sweden).
abstract: A battery of biochemical biomarkers and the SigmaPCB concentration in adult female perch (Perca fluviatilis) verified an aquatic pollution gradient with the city of Stockholm (Sweden) as a point source of anthropogenic substances. The investigation included both an upstream gradient, 46 km westwards through Lake Mälaren, and a downstream gradient, 84 km eastwards through the Stockholm archipelago. Besides the main gradient from Stockholm, there were strong indications of pollution coming from the Baltic Sea. The results indicated a severe pollution situation in central Stockholm, with poor health status of the perch, characterised by increased specific EROD activity in the liver, increased liver EROD somatic index, decreased AChE activity in the muscle, increased amount of DNA adducts in the liver, and a high concentration of biliary 1-pyrenol. In addition, laboratory exposure to common EROD inducers elicited an abnormal response, suggestive of chronic intoxication.
authors.affiliation: Department of Applied Environmental Science, Stockholm University, SE-106 91 Stockholm, Sweden. tomas.hansson@itm.su.se
authors.forename: Tomas
authors.initials: T
authors.lastname: Hansson
authors.forename: Doris
authors.initials: D
authors.lastname: Schiedek
authors.forename: Kari K
authors.initials: KK
authors.lastname: Lehtonen
authors.forename: Pekka J
authors.initials: PJ
authors.lastname: Vuorinen
authors.forename: Birgitta
authors.initials: B
authors.lastname: Liewenborg
authors.forename: Erik
authors.initials: E
authors.lastname: Noaksson
authors.forename: Ulla
authors.initials: U
authors.lastname: Tjärnlund
authors.forename: Marsha
authors.initials: M
authors.lastname: Hanson
authors.forename: Lennart
authors.initials: L
authors.lastname: Balk
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D019363:Cytochrome P-450 CYP1A1 / Q000032:analysis; D018736:DNA Adducts / Q000032:analysis; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D005260:Female; D005618:Fresh Water / Q000737:chemistry*; D005982:Glutathione Transferase / Q000032:analysis; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008668:Metallothionein / Q000032:analysis; D018482:Muscle, Skeletal / Q000378:metabolism; D010471:Perches / Q000033:anatomy & histology / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000032:analysis; D012621:Seasons; D013548:Sweden; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity
chemical_list: D015415:Biomarkers; D018736:DNA Adducts; D014874:Water Pollutants, Chemical; D008668:Metallothionein; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D000110:Acetylcholinesterase