[Study on the correlations between HBsAg and hepatitis C virus expression as well as fibrotic staging in hepatocellular carcinoma and pericarcinomatous tissues].
OBJECTIVE
To study the correlation between hepatitis B virus surface antigen (HBsAg) and hepatitis C virus (HCV) expression as well as fibrosis staging in hepatocellular carcinoma (HCC) and pericarcinomatous tissues.


METHODS
The patterns of HBsAg and HCV in 100 cases of HCC and their surrounding liver tissues were studied on paraffin-embeded sections with immunohistochemistry technique, and liver tissues were also staged.


RESULTS
HBV, HCV virus infection were positively correlated with the fibrotic staging (r(s) = 0.32, P = 0.001). HBsAg and HCV were detected both in HCC and pericarcinomatous tissues. The positive rate of HBsAg in Pericarcinomatous Tissues (79%) was higher than that of in HCC tissues (23%). HCV expressions in HCC (15%) and pericarcinomatous tissues (23%) showed no significant differences.


CONCLUSIONS
The fibrotic degree in the tissues of liver cancer with previous virus infection was obviously higher than that without virus infection. Viral infection seemed to be one of the reasons causing liver cancer while perennial virusemia would aggravate pathological changes of the liver tissue.
Xuan
Shi-ying
SY
Department of Liver Disease, Qingdao Municipal Hospital, Qingdao 266011, China.
Xin
Yong-ning
YN
Chen
Hua
H
Shi
Guang-jun
GJ
Sun
Ying
Y
Zhang
Jian
J
D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000821:virology; D016174:Hepacivirus / Q000302:isolation & purification*; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications; D018936:Hepatitis C Antigens / Q000235:genetics; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology* / Q000821:virology; D011230:Precancerous Conditions / Q000473:pathology* / Q000821:virology; D012307:Risk Factors
D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens