title: Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary.
abstract: BACKGROUND
  In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients.
  
  
  METHODS
  The clinical and histological data of 1694 CRC patients (M/F: 917/777, age at diagnosis: 65.2 +/- SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively.
  
  
  RESULTS
  CRCs were rectal or left-sided in 70% and proximal (transverse, ascending or cecum) in 30% of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6% vs. 1999-2004: 42.1%, p=0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p=0.02); 75.7% of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7%.
  
  
  CONCLUSIONS
  In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest, Hungary. fuszpet@bel1.sote.hu
authors.forename: Peter
authors.initials: P
authors.lastname: Fuszek
authors.forename: Henrik Csaba
authors.initials: HC
authors.lastname: Horvath
authors.forename: Gabor
authors.initials: G
authors.lastname: Speer
authors.forename: Janos
authors.initials: J
authors.lastname: Papp
authors.forename: Petra
authors.initials: P
authors.lastname: Haller
authors.forename: Simon
authors.initials: S
authors.lastname: Fischer
authors.forename: Judit
authors.initials: J
authors.lastname: Halasz
authors.forename: Balazs
authors.initials: B
authors.lastname: Jaray
authors.forename: Eszter
authors.initials: E
authors.lastname: Szekely
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Schaff
authors.forename: Andras
authors.initials: A
authors.lastname: Papp
authors.forename: Attila
authors.initials: A
authors.lastname: Bursics
authors.forename: Laszlo
authors.initials: L
authors.lastname: Harsanyi
authors.forename: Peter
authors.initials: P
authors.lastname: Lukovich
authors.forename: Peter
authors.initials: P
authors.lastname: Kupcsulik
authors.forename: Erika
authors.initials: E
authors.lastname: Hitre
authors.forename: Peter Laszlo
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D012737:Sex Factors