title: Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.
abstract: Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways.
authors.affiliation: Botswana-Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone.
authors.forename: Florence
authors.initials: F
authors.lastname: Doualla-Bell
authors.forename: Ava
authors.initials: A
authors.lastname: Avalos
authors.forename: Tendani
authors.initials: T
authors.lastname: Gaolathe
authors.forename: Madisa
authors.initials: M
authors.lastname: Mine
authors.forename: Simani
authors.initials: S
authors.lastname: Gaseitsiwe
authors.forename: Ndwapi
authors.initials: N
authors.lastname: Ndwapi
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Novitsky
authors.forename: Bluma
authors.initials: B
authors.lastname: Brenner
authors.forename: Maureen
authors.initials: M
authors.lastname: Oliveira
authors.forename: Daniella
authors.initials: D
authors.lastname: Moisi
authors.forename: Howard
authors.initials: H
authors.lastname: Moffat
authors.forename: Ibou
authors.initials: I
authors.lastname: Thior
authors.forename: Max
authors.initials: M
authors.lastname: Essex
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wainberg
mesh_terms: D019943:Amino Acid Substitution; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D017320:HIV Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D009154:Mutation; D019888:Nelfinavir / Q000494:pharmacology* / Q000627:therapeutic use; D010802:Phylogeny; D011110:Polymorphism, Genetic; D015995:Prevalence; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D012641:Selection, Genetic; D017211:Treatment Failure; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D019888:Nelfinavir