Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats.
The aim of this study was to investigate imipenem distribution in muscle and lung interstitial fluids of rats with Acinetobacter baumannii pulmonary infection. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.
Dahyot
Claire
C
EA 3809, Faculté de Médecine et de Pharmacie de Poitiers, France.
Marchand
Sandrine
S
Pessini
Greisiele Lorena
GL
Pariat
Claudine
C
Debaene
Bertrand
B
Couet
William
W
Mimoz
Olivier
O
D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D045604:Extracellular Fluid / Q000378:metabolism*; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D008297:Male; D017551:Microdialysis / Q000379:methods*; D018482:Muscle, Skeletal / Q000378:metabolism*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D015378:Imipenem