Alveolar hemorrhage associated with platelet glycoprotein IIb/IIIa receptor inhibitors.
Platelet glycoprotein IIb/IIIa receptor inhibitors have been shown to improve outcomes in percutaneous coronary interventions. Their use with multiple anticoagulants has been associated with increased bleeding complications. Among these, alveolar hemorrhage is a rare and potentially fatal complication. Six patients with this complication were identified over a four-year period. Patient characteristics, possible risk factors, pathophysiology, prevention and potential treatment options are discussed.
Ener
Rasih Atilla
RA
Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Bruno
Nichole
N
Dadourian
Daniel
D
Wolf
Nelson
N
Van Decker
William
W
Burke
James
J
Styler
Michael
M
Topolsky
David
D
D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011650:Pulmonary Alveoli / Q000098:blood supply*; D012307:Risk Factors
D000925:Anticoagulants; D019039:Platelet Glycoprotein GPIIb-IIIa Complex