Stem cell transplantation for polycythemia vera.
Polycythemia vera (PV) is a rare disease in children. A 9-year-old male was diagnosed following laboratory results acquired because of an acute appendicitis. Regular phlebotomy was performed for over 2 years followed by alpha-interferon treatment. At the age of 12 years, HLA-matched unrelated stem cell transplantation including T-cell depletion was done. The conditioning regimen consisted of busulfan, cyclophosphamide, and ATG. Chimerism was monitored during the whole post-transplant period. A single dose of donor T-lymphocytes was given at month 3. One year after transplantation, chimerism was complete. The patient is in complete remission and shows no signs of transplant-related morbidity at month 78.
Reinhard
Harald
H
Pediatric Hematology and Oncology, University Hospital, Homburg/Saar, Germany.
Klingebiel
Thomas
T
Lang
Peter
P
Bader
Peter
P
Niethammer
Dietrich
D
Graf
Norbert
N
D002648:Child; D006801:Humans; D008297:Male; D011087:Polycythemia Vera / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous