RNA interference pinpoints regulators of cell size and the cell cycle.
Cell-based genome-wide RNA interference screens are being used to address an increasingly broad spectrum of biological questions. In one recent screen, Drosophila cell cultures treated with double-stranded RNA were analyzed by flow cytometry, providing a wealth of new information and identifying 488 regulators of the cell cycle, cell size, and cell death.
Cully
Megan J
MJ
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Leevers
Sally J
SJ
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D048429:Cell Size; D004330:Drosophila / Q000166:cytology / Q000235:genetics; D017344:Genes, Insect; D023281:Genomics; D034622:RNA Interference