Dopamine agonist therapy for Parkinson disease and pathological gambling.
We report 6 patients with pathological gambling during pharmacologic treatment for Parkinson disease (PD). Four patients were treated with levodopa/carbidopa and dopamine agonist (DA), and 2 patients received DA monotherapy. We reviewed several published reports regarding pathological gambling and antiparkinsonian therapy and suggest that more advanced PD and antiparkinsonian combination therapy (e.g., levodopa/carbidopa and DA) increases the risk for development of pathological gambling behavior compared with monotherapy with either DA or levodopa/carbidopa.
Imamura
Akiko
A
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Uitti
Ryan J
RJ
Wszolek
Zbigniew K
ZK
D002230:Carbidopa / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000009:adverse effects*; D005260:Female; D005715:Gambling; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D016239:MEDLINE / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D012189:Retrospective Studies
D018491:Dopamine Agonists; D007980:Levodopa; D002230:Carbidopa