[Advances in researches on single-nucleotide polymorphisms of candidate genes for type 2 diabetes].
Type 2 diabetes is a common multifactorial genetic syndrome, which is determined by several different genes and environmental factors. With the accomplishment of Human Genome Project and the development of the screening technology for single-nucleotide polymorphisms (SNP), many SNP researches have been carried out to determine the genetic factors involved in type 2 diabetes. This article introduces the strategies of SNP studies and reviews the SNP studies of major candidate genes for type 2 diabetes.
Liu
Yang
Y
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Liu
Ying
Y
D052242:Adiponectin / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
D052242:Adiponectin; D047495:PPAR gamma