title: [Hormonal shifts in chronic hepatic diseases].
abstract: The authors offer quantitative evaluation of system cooperation of endocrine functions in healthy individuals, and apply a system approach to diagnostics of chronic liver diseases. The study included analysis of rectilinear and curvilinear correlations between endocrine system parameters in healthy individuals, and shifts in the levels of multilateral associations between the concentrations of various hormones in patients with different degree of the pathologic process in the liver. The study revealed system disintegration which occurs in the organism in cases of liver involvement and found that all liver diseases are associated with pronounced shifts in the condition of the hormonal system. The authors recommend distinguishing certain bands of the functional condition of the organism, which would allow determination of health status, risk groups, presence and prognosis of an illness. Analysis of hormonal status revealed elevation of excessiveness coefficient in liver diseases. The study established parameters that do not only allow quantitative evaluation of system disintegration of the endocrine system functioning, but differentiation of these diseases as well. The results suggest that cooperation of hormonal functions and their intermodal stability underlie the functional condition of both the endocrine system and the entire organism. Integral indices, unlike qualitative characteristics of individual functions, possess high diagnostic and prognostic relevance.
authors.forename: T A
authors.initials: TA
authors.lastname: Dronova
authors.forename: A V
authors.initials: AV
authors.lastname: Zav'ialov
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004703:Endocrine System / Q000378:metabolism*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006728:Hormones