[Antiepileptic drugs and epileptic seizures].
Methodological problems of the influence of antiepileptic drugs (AED) on epileptic seizures are characterized. An analysis of 505 patients with diagnosis of pharmacoresistant epilepsy has been conducted. In 187 (37%) patients the causes of treatment resistance were as follows: overtreatment (73 patients; 14.5%), inadequate AED prescription--potentially predicted effects--(69 patients; 13.7%), paradoxical reactions to AED (45 patients; 8.9%). Inadequately prescribed were mostly carbamazepine and phenytoin and the drug with paradoxical effect--valproate.
Karlov
V A
VA
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans
D000927:Anticonvulsants