Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: "towards tailor-made HLA mismatching".
The immunogenicity of an individual human leukocyte antigen (HLA) class I mismatch is different for the cellular and the humoral alloimmune responses. The consequence is that the same antigen can induce a strong antibody response and no cytotoxic T lymphocyte reactivity, but the reverse can occur also. Exact knowledge of the immunogenicity of an HLA mismatch for an individual patient can lead to a strategy of tailor-made HLA mismatching if no HLA identical donor is available. Depending on the clinical situation, one should select a donor with HLA mismatches according to the humoral or cellular mismatch algorithm.
Claas
Frans H J
FH
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, the Netherlands. fbjclaas@lumc.nl
Roelen
Dave L
DL
Mulder
Arend
A
Doxiadis
Ilias I N
II
Oudshoorn
Machteld
M
Heemskerk
Martin
M
D000917:Antibody Formation; D046148:Donor Selection; D006680:HLA Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular; D007519:Isoantigens / Q000276:immunology*
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D007519:Isoantigens