[Researches on genetics and genetic epidemiology of common complex diseases: challenge and strategies].
With the rapid development of human genome project, increased genetic and population-based association studies are focused on the identification of the underlying susceptibility genes and contributions from gene-environment interaction to common complex diseases. Whole-genome association study with high-density single nucleotide polymorphisms is one of the most important milestones in that process. However, problems still exist in study design, data processing, and results interpretation. Large-scale cohort study or population-based case-control design with sufficient statistical power, new approaches to assess the gene-gene and gene-environment interactions, as guarantee of the consistency and replicability of these researches are crucial in the exploration of the causes of these common complex diseases.
Gu
Dong-feng
DF
Department of Evidence Based Medicine and Population Genetics, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMC, Beijing 100037, China. gudongfeng@vip.sina.com
D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D017720:Molecular Epidemiology; D010641:Phenotype
D005819:Genetic Markers