title: Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains.
abstract: Long RNA electropherotype rotavirus strains with subgroup I specificity predominated the infantile gastroenteritis outbreak in Manipur, India, in 1987-88. One such strain (RMC321) was found to possess porcine characteristics in 7 out of 8 genes sequenced. Partial characterization of its remaining VP1, VP2 and VP3 genes along with a porcine rotavirus strain (HP140) uncovered their close genetic relation to porcine strains. VP7 was the only gene segment of this strain with significant genetic identity to human strains. This indicates that a rotavirus reassortant strain with most of its genetic material derived from a porcine strain may cause symptomatic infection in a human host.
authors.affiliation: Division of Virology, National Institute of Cholera and Enteric Diseases, C.I.T. Road, Scheme XM, Beliaghata, P-33, 700010, Kolkata, India.
authors.forename: Vici
authors.initials: V
authors.lastname: Varghese
authors.forename: Souvik
authors.initials: S
authors.lastname: Ghosh
authors.forename: Soma
authors.initials: S
authors.lastname: Das
authors.forename: Sujit Kumar
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: Triveni
authors.initials: T
authors.lastname: Krishnan
authors.forename: Parimal
authors.initials: P
authors.lastname: Karmakar
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Trailokya Nath
authors.initials: TN
authors.lastname: Naik
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics*; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007194:India / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA; D013552:Swine / Q000821:virology*; D013553:Swine Diseases / Q000821:virology; D014758:Viral Core Proteins / Q000235:genetics*
chemical_list: D036022:Capsid Proteins; C069187:VP1 protein, Rotavirus; C442545:VP2 protein, Rotavirus; C442546:VP3 protein, Rotavirus; D014758:Viral Core Proteins