title: Evolving concepts in the pathogenesis of hairy-cell leukaemia.
abstract: Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B-cell tumours (for example, chromosomal translocations and consistent lymph node involvement) and show unique features like 'hairy' morphology and bone-marrow fibrosis? Gene-expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.
authors.affiliation: Institute of Haematology, University of Perugia, Italy. enrico.tiacci@uni-essen.de
authors.forename: Enrico
authors.initials: E
authors.lastname: Tiacci
authors.forename: Arcangelo
authors.initials: A
authors.lastname: Liso
authors.forename: Miguel
authors.initials: M
authors.lastname: Piris
authors.forename: Brunangelo
authors.initials: B
authors.lastname: Falini
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D008207:Lymphatic Metastasis; D008954:Models, Biological; D015398:Signal Transduction; D014178:Translocation, Genetic