Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells.
Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Ralpha, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.
Johnson-Nauroth
Julie M
JM
Department of Neurology, School of Medicine, Johns Hopkins University, Johns Hopkins Hospital, Pathology Building 627, 600 N. Wolfe St., Baltimore, MD 21287-6965, United States.
Graber
Jerome
J
Yao
Karen
K
Jacobson
Steve
S
Calabresi
Peter A
PA
D016356:Gene Products, tax / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000032:analysis; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000032:analysis; D020395:Receptors, Interleukin-7 / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
C515370:CCR7 protein, human; D016356:Gene Products, tax; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain; D017493:Leukocyte Common Antigens