title: Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
abstract: We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.
authors.affiliation: Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Moss
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carletti
authors.forename: Carlos
authors.initials: C
authors.lastname: Olano
authors.forename: Rose M
authors.initials: RM
authors.lastname: Sheridan
authors.forename: Michael
authors.initials: M
authors.lastname: Ward
authors.forename: Vidya
authors.initials: V
authors.lastname: Math
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nur-E-Alam
authors.forename: Alfredo F
authors.initials: AF
authors.lastname: Braña
authors.forename: Ming Qiang
authors.initials: MQ
authors.lastname: Zhang
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
authors.forename: Carmen
authors.initials: C
authors.lastname: Méndez
authors.forename: José A
authors.initials: JA
authors.lastname: Salas
authors.forename: Barrie
authors.initials: B
authors.lastname: Wilkinson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*; D013237:Stereoisomerism
chemical_list: D020533:Angiogenesis Inhibitors; D005233:Fatty Alcohols; C005066:borrelidin