title: Developments and hurdles in generating vaccines for controlling helminth parasites of grazing ruminants.
abstract: As a direct consequence of rising drug resistance among common nematodes of grazing animals, efforts toward state-of-the-art vaccine development have clearly intensified in recent years, fuelled primarily by the advent of newer technologies in gene discovery, by advancements in antigen identification, characterisation and production. In this regard, it is appropriate to review progress that has been made in generating helminth vaccines and in particular, vaccines against common nematodes of production animals for consumption. In like manner, it is prudent to evaluate barriers that have hindered progress in the past and continue to present obstacles that must be solved when utilizing and depending on host immunity to attenuate parasitic infections.
authors.affiliation: Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK. smitd@mri.sari.ac.uk
authors.forename: W D
authors.initials: WD
authors.lastname: Smith
authors.forename: D S
authors.initials: DS
authors.lastname: Zarlenga
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics / Q000469:parasitology*; D000947:Antigens, Helminth / Q000235:genetics / Q000276:immunology; D004351:Drug Resistance; D014644:Genetic Variation; D006374:Helminthiasis, Animal / Q000276:immunology / Q000517:prevention & control*; D006376:Helminths / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D006790:Host-Parasite Interactions; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D012418:Ruminants / Q000235:genetics / Q000469:parasitology*; D014612:Vaccines / Q000276:immunology
chemical_list: D000947:Antigens, Helminth; D014612:Vaccines