title: Proton NMR analysis of plasma is a weak predictor of coronary artery disease.
abstract: Multivariate analysis of 1H-NMR spectra of blood sera was reported previously to predict angiographically defined advanced coronary artery disease (CAD) with >90% accuracy and specificity. The analysis depended mainly on the major lipid regions of the spectra, but many variables, including gender and drug treatment, affect lipid composition and are potential confounders. We have determined the predictive power of the same methodology for angiographically defined CAD using plasma samples from groups of male patients, classified by statin treatment, who had normal coronary arteries (NCAs) or CAD. Predictions for NCA and CAD groups were only 80.3% correct for patients not treated with statins and 61.3% for treated patients, compared with random correct predictions of 50%. A confidence limit of >99% was achieved for 36.2% of predictions for untreated groups and 6.2% for treated groups. Detection of CAD by 1H-NMR with >99% confidence was therefore very weak compared with angiography.
authors.affiliation: Department of Biochemistry, University of Cambridge, Building O, Downing Site, Tennis Court Road, Cambridge CB2 1QW, UK.
authors.forename: Heide L
authors.initials: HL
authors.lastname: Kirschenlohr
authors.forename: Julian L
authors.initials: JL
authors.lastname: Griffin
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Clarke
authors.forename: Ranyl
authors.initials: R
authors.lastname: Rhydwen
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Grace
authors.forename: Peter M
authors.initials: PM
authors.lastname: Schofield
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Brindle
authors.forename: James C
authors.initials: JC
authors.lastname: Metcalfe
mesh_terms: D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D015999:Multivariate Analysis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010949:Plasma / Q000737:chemistry*; D011237:Predictive Value of Tests; D011522:Protons
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011522:Protons