Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains.
Long RNA electropherotype rotavirus strains with subgroup I specificity predominated the infantile gastroenteritis outbreak in Manipur, India, in 1987-88. One such strain (RMC321) was found to possess porcine characteristics in 7 out of 8 genes sequenced. Partial characterization of its remaining VP1, VP2 and VP3 genes along with a porcine rotavirus strain (HP140) uncovered their close genetic relation to porcine strains. VP7 was the only gene segment of this strain with significant genetic identity to human strains. This indicates that a rotavirus reassortant strain with most of its genetic material derived from a porcine strain may cause symptomatic infection in a human host.
Varghese
Vici
V
Division of Virology, National Institute of Cholera and Enteric Diseases, C.I.T. Road, Scheme XM, Beliaghata, P-33, 700010, Kolkata, India.
Ghosh
Souvik
S
Das
Soma
S
Bhattacharya
Sujit Kumar
SK
Krishnan
Triveni
T
Karmakar
Parimal
P
Kobayashi
Nobumichi
N
Naik
Trailokya Nath
TN
D000818:Animals; D036022:Capsid Proteins / Q000235:genetics*; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007194:India / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA; D013552:Swine / Q000821:virology*; D013553:Swine Diseases / Q000821:virology; D014758:Viral Core Proteins / Q000235:genetics*
D036022:Capsid Proteins; C069187:VP1 protein, Rotavirus; C442545:VP2 protein, Rotavirus; C442546:VP3 protein, Rotavirus; D014758:Viral Core Proteins