Non-immune thrombocytopenia responsive to antiretroviral therapy and HIV-2 infection.
HIV-2 infection was documented for the first time in Venezuela, in a heterosexual couple. Two identical subtype A viral strains exhibiting multiple resistance mutations to antiretroviral drugs were identified. One of the patients suffered from progressive non-immune thrombocytopenia and extranodal NK/T-cell type lymphoma, an association not previously described for HIV-2. His hematological condition promptly improved after onset of an effective antiretroviral therapy.
Torres
Jaime R
JR
Infectious Diseases Section, Topical medicine Institute, Universidad Central de Venezuela, Caracas, Venezuela. torresj@post.com
Torres-Viera
Maria A
MA
Schupbach
Jorg
J
Rangel
Hector R
HR
Pujol
Flor H
FH
D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005192:Family Health; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D015498:HIV-2 / Q000302:isolation & purification*; D020010:Heterosexuality; D006801:Humans; D008223:Lymphoma; D008297:Male; D013921:Thrombocytopenia / Q000150:complications*; D014687:Venezuela
D019380:Anti-HIV Agents