Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis.
OBJECTIVE
Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia.


METHODS
Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls.


RESULTS
No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls.


CONCLUSIONS
Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.
Bowlus
Christopher L
CL
Division of Gastroenterology, University of California Davis Medical Center, 4150 V Street, PSSB3500, Sacramento, CA 95817, USA.
Karlsen
Tom H
TH
Broomé
Ulrika
U
Thorsby
Erik
E
Vatn
Morten
M
Schrumpf
Erik
E
Lie
Benedicte A
BA
Boberg
Kirsten Muri
KM
D016022:Case-Control Studies; D015815:Cell Adhesion Molecules; D015209:Cholangitis, Sclerosing / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D015212:Inflammatory Bowel Diseases; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D009088:Mucoproteins / Q000235:genetics*; D009664:Norway; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013548:Sweden
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; C504265:MADCAM1 protein, human; D009088:Mucoproteins; D018799:Intercellular Adhesion Molecule-1