An overview of the serpin superfamily.
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.
Law
Ruby H P
RH
Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne VIC 3800, Australia.
Zhang
Qingwei
Q
McGowan
Sheena
S
Buckle
Ashley M
AM
Silverman
Gary A
GA
Wong
Wilson
W
Rosado
Carlos J
CJ
Langendorf
Chris G
CG
Pike
Rob N
RN
Bird
Philip I
PI
Whisstock
James C
JC
D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D011487:Protein Conformation; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000145:classification / Q000502:physiology*; D015843:Serpins / Q000737:chemistry* / Q000145:classification / Q000502:physiology*
D015842:Serine Proteinase Inhibitors; D015843:Serpins