title: Long-term follow up of diabetic patients treated with sirolimus-eluting stents. An angiographic and three-dimensional intravascular ultrasound study.
abstract: BACKGROUND
  Sirolimus-eluting stents (SES) have already demonstrated their long-term effectiveness in suppressing neointimal hyperplasia in non-high risk patients. The long-term follow up of diabetic patients treated with SES has not been yet evaluated.
  
  
  RESULTS
  Quantitative coronary angiography and intravascular ultrasound analysis were performed in 35 diabetic patients treated with a SES at short- (6.0 +/- 1.0 months) and long-term (18.5 +/- 4.9 months) follow up. There were no significant changes in the in-stent minimum lumen diameter (MLD) between short- and long-term follow up (2.69 +/- 0.46 vs. 2.61 +/- 0.44 mm; p = 0.5), as well as in the in-lesion MLD (2.38 +/- 0.54 vs. 2.30 +/- 0.62 mm; p = 0.6). None of the patients reached binary restenosis (diameter stenosis > 50%) at either follow-up periods. Stent obstruction volume by 3-D IVUS was very small at short-term follow up and has remained virtually the same at long-term follow up (3.4% vs. 3.5%; p = 0.8). There were no aneurysm formations, late stent strut malappositions or late stent thromboses.
  
  
  CONCLUSIONS
  The present study demonstrates the 18-month efficacy and safety of SES for the treatment of diabetic patients without the so-called late catch-up phenomenon.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
authors.forename: Vinicius D
authors.initials: VD
authors.lastname: Vaz
authors.forename: Alexandre
authors.initials: A
authors.lastname: Abizaid
authors.forename: Aurea
authors.initials: A
authors.lastname: Chaves
authors.forename: Fausto
authors.initials: F
authors.lastname: Feres
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ferreira
authors.forename: Luiz
authors.initials: L
authors.lastname: Mattos
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Staico
authors.forename: Andrea
authors.initials: A
authors.lastname: Abizaid
authors.forename: Luiz
authors.initials: L
authors.lastname: Tanajura
authors.forename: Marinella
authors.initials: M
authors.lastname: Centemero
authors.forename: Gary
authors.initials: G
authors.lastname: Mintz
authors.forename: Amanda
authors.initials: A
authors.lastname: Sousa
authors.forename: J Eduardo
authors.initials: JE
authors.lastname: Sousa
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000008:administration & dosage* / Q000627:therapeutic use; D015607:Stents; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D020123:Sirolimus