Abdominal wound dehiscence in patients receiving long-term steroid treatment.
Steroids inhibit primary wound healing and delay the formation of granulation tissue, but it has been controversial whether long-term steroid treatment by itself increases the risk of abdominal wound dehiscence. The aim of this study was to determine whether the pre-operative dose and post-operative total dose of steroids influence abdominal wound dehiscence. Of 28 patients who had surgery while receiving long-term steroid treatment, seven had abdominal wound dehiscence and 21 did not have dehiscence. The two groups differed significantly in the post-operative dose of steroids (404.3 +/- 147.1 and 135.6 +/- 118.7 mg, respectively) and the duration of wound healing (57.3 +/- 18.0 and 12.4 +/- 3.8 days), but no other differences were found. Abdominal wound dehiscence may be influenced by the post-operative rather than the pre-operative steroid dose.
Kihara
A
A
Department of Coloproctological Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Kasamaki
S
S
Kamano
T
T
Sakamoto
K
K
Tomiki
Y
Y
Ishibiki
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D013256:Steroids / Q000008:administration & dosage / Q000009:adverse effects*; D013529:Surgical Wound Dehiscence / Q000139:chemically induced*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D013256:Steroids