title: KNOX gene function in plant stem cell niches.
abstract: Homeobox genes encode transcriptional regulators that control development in multicellular eukaryotes. In plants, post-embryonic shoot growth relies on the activity of indeterminate cell populations termed shoot meristems, within which members of the class-1 KNOX sub-family of homeobox genes are expressed. KNOX genes are differentially required for meristem development and function to inhibit cell expansion and differentiation associated with organogenesis. Mechanisms must therefore be employed to prevent KNOX gene expression in developing lateral organs such as leaves. This review focuses on the expression patterns, meristematic functions and regulation of KNOX genes, and how the activities of these genes are integrated within the framework of pathways that control plant development.
authors.affiliation: Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Scofield
authors.forename: James A H
authors.initials: JA
authors.lastname: Murray
mesh_terms: D017360:Arabidopsis / Q000033:anatomy & histology / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D019521:Body Patterning; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018519:Meristem / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D010802:Phylogeny; D010937:Plant Growth Regulators / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012098:Reproduction; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D018398:Homeodomain Proteins; C500589:Myb protein, Arabidopsis; D010937:Plant Growth Regulators; D014157:Transcription Factors