[Transcranial electrical stimulation activates the reparative regeneration and insulin-producing function of beta-cells in alloxan-induced diabetic rats].
In alloxan-induced diabetic rats, it was demonstrated that transcranial electrical stimulation of the brain endorphinergic structures activated the reparative regeneration of the damaged beta-cells of the Langerhans pancreatic islets. This was estimated on the histological sections of pancreas with hematoxylin-eosin staining. Several small newborn islets were found to originate from pancreatic progenitor cells. After transcranial electrical stimulation of insulin granules, beta-cells (Gomori's staining) were observed as an indication of the restoration of the insulin production. Correspondingly the increase of the blood insulin level was estimated by immune-enzyme method. The dynamics of the plasma insulin increase had a significant negative correlation with decrease of the blood glucose level. The glucose-lowering action of the transcranial electrical stimulation in alloxan-induced diabetic rats seems to be based on stimulation of the regeneration of damaged beta-cells with the restoration of their insulin production.
Lebedev
V P
VP
Bilichenko
S V
SV
Ordian
N E
NE
Pivina
S G
SG
Nechiporenko
S P
SP
Puzyrev
A A
AA
Mikheeva
E A
EA
Kubacheva
K K
KK
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002540:Cerebral Cortex; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004558:Electric Stimulation; D007328:Insulin / Q000097:blood*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan