[Insulin secretion at the diagnosis of gestational diabetes is lower in multiparas than in primiparas].
Gestational diabetes mellitus (GDM) has heterogeneous ethiopathogenesis, pathophysiology and clinical features.


OBJECTIVE
The aim of the study was to evaluate some of anthropometric parameters, clinical features and indices of insulin resistance and beta cell function in GDM women in first pregnancy and in GDM women in third and following pregnancies.


METHODS
877 GDM women, aged 18-48 years were studied. Both groups were compared according to age, BMI before pregnancy, week of GDM diagnosis, weight gain during pregnancy, fasting blood glucose, fasting serum insulin level, HbA1c, insulin resistance and beta-cell function indices. All parameters except BMI were evaluated at GDM diagnosis.


RESULTS
Multiparas were older, with higher BMI and lower beta-cell function indices.


CONCLUSIONS
At the moment of GDM diagnosis, insulin secretion evaluated by HOMA indices are lower in multiparas in comparison to primaparas.
Sokup
Alina
A
Kameda i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych. alinasokup@o2.pl
Swiatkowski
Maciej
M
Tyloch
Małgorzata
M
Skublicki
Stanisław
S
Szymanski
Wiesław
W
Góralczyk
Krzysztof
K
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006304:Health Status; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D018709:Statistics, Nonparametric; D015430:Weight Gain
D001786:Blood Glucose; D006442:Glycated Hemoglobin