Embryonal carcinoma producing DU-PAN-2 with burned-out phenomenon in the testis.
A burned-out testicular tumor with lung and lymph node metastases presented high serum levels of DU-PAN-2. However, the serum levels of CA19-9, alpha-fetoprotein, beta-human chorionic gonadotropin, and sialyl Lewis X were normal. A biopsy of the cervical lymph nodes revealed embryonal carcinoma. Four courses of chemotherapy, including cisplatin, etoposide, and bleomycin, normalized the level of DU-PAN-2, and the metastatic lesions disappeared. This is the second reported case of an embryonal carcinoma producing DU-PAN-2. The secretor and Lewis gene typings, which affect the normal serum ranges of CA19-9 and DU-PAN-2, were determined.
Fujita
Kazuhiko
K
Division of Urology, Shizuoka Hospital, Juntendo University School of Medicine, Shizuoka, Japan. fujitajus@cup.ocn.ne.jp
Itoh
Yukio
Y
Wada
Ryo
R
Nagao
Keiji
K
Fujime
Makoto
M
D000328:Adult; D000912:Antibodies, Neoplasm / Q000097:blood; D000951:Antigens, Neoplasm / Q000097:blood* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood* / Q000276:immunology; D001706:Biopsy; D018236:Carcinoma, Embryonal / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C042317:DU-PAN-2 antigen, human