title: Cellular genetics of host susceptibility and resistance to virus infection.
abstract: Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.
authors.affiliation: Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA.
authors.forename: Donald H
authors.initials: DH
authors.lastname: Rubin
authors.forename: H Earl
authors.initials: HE
authors.lastname: Ruley
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018390:Gene Targeting; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D016296:Mutagenesis; D011991:Receptors, Virus / Q000235:genetics; D012088:Reoviridae Infections / Q000235:genetics; D015398:Signal Transduction; D014777:Virus Diseases / Q000235:genetics*; D014779:Virus Replication
chemical_list: D011991:Receptors, Virus