Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass.
Dense hydroxyapatite (HA) ceramics are useful bone substitutes, but they degrade minimally. One solution is to incorporate degradable materials in the HA. In this study, we manufactured glass-containing HA and investigated whether the degradability and bone-bonding ability of the HA were improved. The glass-containing HA was manufactured from a mixture of HA powder and 1.0 wt% glass powder. The control HA was manufactured from pure HA powder. In vitro degradability was evaluated by soaking in physiological saline, and a rabbit model was used to evaluate in vivo degradability and bone-bonding ability. Detaching tests were performed for all removed samples to quantify bone-bonding ability of each type of HA. The glass-containing HA showed higher degradability than the control HA, both in vitro and in vivo. The detaching failure load of the glass-containing HA was rapidly elevated after implantation and was higher than that of the control HA. Our results suggest that the dissolution of the added glass made the glass-containing HA degradable and that the detaching failure load of the glass-containing HA was elevated by reinforcement of the mechanical locking at the roughened interface. Incorporation of glass additives into HA can be concluded to be a good candidate for producing a bone substitute that can partially degrade and bond to bone firmly and rapidly.
So
Kazutaka
K
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. so_kazu@kuhp.kyoto-u.ac.jp
Fujibayashi
Shunsuke
S
Neo
Masashi
M
Anan
Yukiko
Y
Ogawa
Tetsuro
T
Kokubo
Tadashi
T
Nakamura
Takashi
T
D020341:Absorbable Implants; D000042:Absorption; D000268:Adhesiveness; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry* / Q000627:therapeutic use*; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use; D017886:Durapatite / Q000737:chemistry* / Q000627:therapeutic use*; D005898:Glass / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D013978:Tibial Fractures / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
D018786:Bone Substitutes; D017886:Durapatite