Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol - induced myocardial infarction in rats.
Crataegus oxycantha (hawthorn) is used in herbal and homeopathic medicine as a cardiotonic. The present study was done to investigate the effect of the alcoholic extract of Crataegus oxycantha (AEC) on mitochondrial function during experimentally induced myocardial infarction in rat. AEC was administered orally to male albino rats (150-200 g), at a dosage of 0.5 ml/100 g body weight/day, for 30 days. At the end of the experimental period, the animals were administered isoproterenol (85 mg/kg body weight, s.c) for 2 days at an interval of 24 h. After 48 h, the rats were anaesthetized and sacrificed. The hearts were homogenized for biochemical and electron microscopic analysis. AEC pretreatment maintained mitochondrial antioxidant status, prevented mitochondrial lipid peroxidative damage and decrease in Kreb's cycle enzymes induced by isoproterenol in rat heart.
Jayalakshmi
R
R
Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India.
Thirupurasundari
C J
CJ
Devaraj
S Niranjali
SN
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002952:Citric Acid Cycle / Q000187:drug effects; D027825:Crataegus / Q000737:chemistry*; D007545:Isoproterenol / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000188:drug therapy*; D009206:Myocardium / Q000648:ultrastructure; D010545:Peroxides / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D010545:Peroxides; D010936:Plant Extracts; D013482:Superoxide Dismutase; D007545:Isoproterenol