[Correlation between the expression of HER-2/neu, nm23 protein and local invasion and lymph node metastasis of human LSCC].
OBJECTIVE
To explore the relationship between the expressions of HER-2/neu, nm23 protein and local invasion and lymp node metastasis of LSCC.


METHODS
The expression of HER-2/neu, nm23 protein was detected by immunohistochemical technique in 56 patients with human LSCC.


RESULTS
The positive expression rate of HER-2/neu protein in LSCC was not correlated with histological grade (P > 0.05). There was a significant relationship between the expression of HER-2/neu and the clinical stages, lymph node metastasis (P < 0.05, P < 0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than those with lymph node metastasis (P < 0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of LSCC. Furthermore, the negative correlation was found between the positive expression of HER-2/neu protein and the positive expression of nm23 protein in the group with lymph node metastasis.


CONCLUSIONS
The abnormal expression of HER-2/neu, nm23 protein play an important role in development and lymph node metastasis of LSCC.
Li
Qin
Q
Department of Otorhinolaryngology, Linyi People's Hospital, Linyi, 276003, China. liqin8226@163.com
Chen
Yanlin
Y
Kong
Ping
P
Ming
Wei
W
Ma
Yanyan
Y
Yang
Zhaoke
Z
Du
Yinghua
Y
Zhang
Daliang
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D009362:Neoplasm Metastasis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human; C517938:NME1 protein, human