title: Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica.
abstract: 1-Hydroxy-2,3,5-trimethoxyxanthone (1), one of the major xanthone derivatives isolated from Halenia elliptica, was biotransformed by two fungi, Trichothecium roseum and Paecilomyces marquandii. Transformation of 1 by T. roseumgave 1,5-dihydroxy-2,3-dimethoxyxanthone (2), 5-O-sulfate-1-hydroxy-2,3-dimethoxyxanthone (3), 5-O-sulfate-1-hydroxy-2,3,7-trimethoxyxanthone (4), 5-O-beta-ribofuranosyl-1-hydroxy-2,3-dimethoxyxanthone (5), and 1,5,6-trihydroxy-2,3-dimethoxyxanthone (6). Compound 2 was also formed by P. marquandii. The structures of the isolated compounds were elucidated by spectroscopic analyses. Among the five microbial-converted compounds, 3, 4, 5, and 6 are new compounds.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Ke-Di
authors.initials: KD
authors.lastname: Cheng
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Quan
authors.initials: Q
authors.lastname: Wang
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: He
authors.forename: Hui-Xin
authors.initials: HX
authors.lastname: Zhu
mesh_terms: D001203:Ascomycota / Q000378:metabolism; D001711:Biotransformation; D029965:Gentianaceae / Q000737:chemistry*; D006900:Hydroxylation; D015394:Molecular Structure; D010143:Paecilomyces / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
chemical_list: C478004:1-hydroxy-2,3,5-trimethoxyxanthone; D044004:Xanthones