title: In vitro activities of DX-619 and comparison quinolones against gram-positive cocci.
abstract: The in vitro activity of the novel quinolone DX-619 was compared to those of currently available quinolones against U.S. clinical isolates of Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus spp., Streptococcus pyogenes, and Streptococcus pneumoniae. DX-619 was the most potent quinolone overall, indicating possible utility as an anti-gram-positive quinolone.
authors.affiliation: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, NE 68178, USA. pwickman@creighton.edu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Wickman
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Black
authors.forename: Ellen Smith
authors.initials: ES
authors.lastname: Moland
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Thomson
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D015242:Ofloxacin / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; C505440:DX 619; D024841:Fluoroquinolones; D011759:Pyrrolidines; D011804:Quinolines; D015363:Quinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin; D000077266:Moxifloxacin