Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst.
The bifunctional thiourea-tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.
Liu
Tian-Yu
TY
Key Laboratory of Drug-Targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Long
Jun
J
Li
Bang-Jing
BJ
Jiang
Lin
L
Li
Rui
R
Wu
Yong
Y
Ding
Li-Sheng
LS
Chen
Ying-Chun
YC
D000085:Acetates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry; D006860:Hydrogen Bonding; D013237:Stereoisomerism; D013379:Substrate Specificity; D013450:Sulfones / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry
D000085:Acetates; D000596:Amino Acids; D003959:Diamines; D013450:Sulfones; C009873:divinyl sulfone; D013890:Thiourea; C007170:cyanoacetic acid