Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis.
This report describes the isolation and characterization of kalanchosine dimalate (KMC), an anti-inflammatory salt from the fresh juice of the aerial parts of Kalanchoe brasiliensis. KMC comprises the new metabolite kalanchosine (1) and malic acid (2) in a 1:2 stoichiometric ratio. Kalanchosine (1), 3,6-diamino-4,5-dihydroxyoctanedioic acid, is the first naturally occurring dimeric bis(gamma-hydroxy-beta-amino acid) and is at least partially responsible for the anti-inflammatory properties of K. brasiliensis.
Costa
Sônia Soares
SS
Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21 941-590 Rio de Janeiro, RJ, Brazil. sscosta@nppn.ufrj.br
de Souza
Maria de Lourdes Mendes
Mde L
Ibrahim
Tereza
T
de Melo
Giany Oliveira
GO
de Almeida
Ana Paula
AP
Guette
Catherine
C
Férézou
Jean-Pierre
JP
Koatz
Vera Lucia G
VL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D031962:Kalanchoe / Q000737:chemistry*; D008293:Malates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008293:Malates; C511573:kalanchosine dimalate; C030298:malic acid