Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: experience in a Mexican institution.
OBJECTIVE
To assess the prevalence and clinical value of p-ANCA in a sample of Mexican ulcerative colitis (UC) patients.


METHODS
In a prospective, IRB-approved protocol, p-ANCA was determined in 80 patients with UC (mean age, 32 +/- 12.9 years). The severity and extension of disease were determined by clinical methods, searching a statistical association with p-ANCA status.


RESULTS
p-ANCA were detected in 41 (51%) patients. Severity of disease was the only clinical variable statistically associated with their presence (P < 0.0001; OR = 9; CI 95% = 3.2-24.7).


CONCLUSIONS
The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.
Yamamoto-Furusho
Jesus K
JK
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Takahashi-Monroy
Takeshi
T
Vergara-Fernandez
Omar
O
Reyes
Edgardo
E
Uscanga
Luis
L
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000502:physiology; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000097:blood* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D011446:Prospective Studies; D012720:Severity of Illness Index
D019268:Antibodies, Antineutrophil Cytoplasmic