title: The effect of periodontal therapy on TNF-alpha, IL-6 and metabolic control in type 2 diabetics.
abstract: OBJECTIVE
  This pilot study investigated if scaling and root planing (S&RP) was an effective intervention in reducing levels of inflammatory markers TNF-alpha and IL-6 in a type 2 diabetic population.
  
  
  METHODS
  Twenty-five patients with type 2 diabetes, 18-64 years of age were enrolled having 4 or more sites with pocket depths > or = 5mm and 2 or more sites with attachment loss > or = 3mm. Participants received S&RP following collection of gingival crevicular fluid and serum which were analyzed for TNF-alpha and IL-6. After 3 months post-treatment levels were collected. Serum pre-and post-treatment levels were analyzed using a paired t test at a significance level of p < or = 0.05. Mean TNF-alpha was 1.7 pg/ml at baseline and post-treatment was 4.0 pg/ml. Mean IL-6 was 2.8 pg/ml at baseline and post-treatment 6.0 pg/ml.
  
  
  RESULTS
  Both mean TNF-alpha and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. While participants improved on periodontal measures following therapy, systemic measures of inflammation (TNF-alpha and IL-6) did not show the hypothesized reductions.
  
  
  CONCLUSIONS
  Further studies are needed to determine effectiveness of S&RP on inflammatory mediators in a population with type 2 diabetes.
authors.affiliation: UNC School of Dentistry, USA. jlhamm@email.unc.edu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Talbert
authors.forename: John
authors.initials: J
authors.lastname: Elter
authors.forename: Heather L
authors.initials: HL
authors.lastname: Jared
authors.forename: Steve
authors.initials: S
authors.lastname: Offenbacher
authors.forename: Janet
authors.initials: J
authors.lastname: Southerland
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Wilder
mesh_terms: D000293:Adolescent; D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000150:complications / Q000628:therapy*; D010865:Pilot Projects; D016745:Root Planing; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000378:metabolism*
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha