A kinetic model of oxygen regulation of cytochrome production in Escherichia coli.
Recent experimental work has identified the principal components arrayed by Escherichia coli in its sensing of, and response to, varying levels of oxygen. This apparatus may be leveraged/modified by the metabolic engineer to identify nonuniform oxygen and glucose regimens that deliver better yields than their uniform counterparts. Toward this end we build and analyse a mathematical model that captures the role played by oxygen in the regulation of cytochrome production in E. coli.
Peercy
Bradford E
BE
Computational and Applied Mathematics, Rice University, 6100 Main Str., MS 134, Houstin, TX 77005, USA. bpeercy@rice.edu
Cox
Steven J
SJ
Shalel-Levanon
Sagit
S
San
Ka-Yiu
KY
Bennett
George
G
D016227:Benzoquinones / Q000378:metabolism; D019149:Bioreactors; D003580:Cytochromes / Q000096:biosynthesis*; D004789:Enzyme Activation; D004926:Escherichia coli / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption
D016227:Benzoquinones; D003580:Cytochromes; C004532:quinone; D005947:Glucose; D010100:Oxygen