title: Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide A, Penicillium jamesonlandense sp. nov., Penicillium ribium sp. nov., Penicillium soppii and Penicillium lanosum.
abstract: Penicillium jamesonlandense is a novel species from Greenland that grows exceptionally slowly at 25 degrees C and has an optimum temperature for growth of 17-18 degrees C. The novel species is more psychrotolerant than any other Penicillium species described to date. Isolates of this novel species produce a range of secondary metabolites with a high chemical diversity, represented by kojic acid, penicillic acid, griseofulvin, pseurotin, chrysogine, tryptoquivalins and cycloaspeptide. Penicillium ribium, another novel psychrotolerant species from the Rocky Mountains, Wyoming, USA, produces asperfuran, kojic acid and cycloaspeptide. Originally reported from an unidentified Aspergillus species isolated from Nepal, cycloaspeptide A is reported here for the first time from the two novel Penicillium species and two known psychrotolerant species with high chemical diversity, Penicillium soppii and Penicillium lanosum. All species, except P. ribium, produce a combination of cycloaspeptide and griseofulvin. However, P. ribium (3/5 strains) produced the precursor to griseofulvin, norlichexanthone. The type strain of Penicillium jamesonlandense sp. nov. is DAOM 234087(T) (=IBT 21984(T) = IBT 24411(T) = CBS 102888(T)) and the type strain of Penicillium ribium sp. nov. is DAOM 234091(T) (=IBT 16537(T) = IBT 24431(T)).
authors.affiliation: Center for Microbial Biotechnology, BioCentrum-DTU, Building 221, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Frisvad
authors.affiliation: Center for Microbial Biotechnology, BioCentrum-DTU, Building 221, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Larsen
authors.affiliation: Center for Microbial Biotechnology, BioCentrum-DTU, Building 221, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Petur W
authors.initials: PW
authors.lastname: Dalsgaard
authors.affiliation: Biodiversity (Mycology and Botany), National Programme on Environmental Science, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6, Canada.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Seifert
authors.affiliation: Biodiversity (Mycology and Botany), National Programme on Environmental Science, Agriculture and Agri-Food Canada, Ottawa, Ontario K1A 0C6, Canada.
authors.forename: Gerry
authors.initials: G
authors.lastname: Louis-Seize
authors.affiliation: Center for Microbial Biotechnology, BioCentrum-DTU, Building 221, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: E K
authors.initials: EK
authors.lastname: Lyhne
authors.affiliation: Department of Chemistry and Biochemistry and the Joint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, MD 20742, USA.
authors.forename: Bruce B
authors.initials: BB
authors.lastname: Jarvis
authors.affiliation: Department of Chemistry and Biochemistry and the Joint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, MD 20742, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Fettinger
authors.affiliation: Institute of Biological Sciences, Edward Llwyd Building, University of Wales, Aberystwyth, Ceredigion SY23 3DA, UK.|Center for Microbial Biotechnology, BioCentrum-DTU, Building 221, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: David P
authors.initials: DP
authors.lastname: Overy
mesh_terms: D014644:Genetic Variation; D008969:Molecular Sequence Data; D010407:Penicillium / Q000145:classification* / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000235:genetics*; D010802:Phylogeny; D012988:Soil Microbiology
chemical_list: D010456:Peptides, Cyclic; C500117:cycloaspeptide A