Effects of bioactive glass on bone augmentation within a titanium cap in rabbit parietal bone.
BACKGROUND
The condition of alveolar bone influences the success and subsequent esthetics of implant treatment. This study investigated the early effects of bioactive glass (BG) on bone augmentation within a hemispherical titanium cap in rabbit parietal bone.


METHODS
Twelve adult male Japanese white rabbits were used. One titanium cap (test site) was packed with BG in a collagen gel, and the other (control site) was packed with the collagen gel alone. After 1 and 3 months, animals were euthanized, and the experimental area was examined using fluorescence and light microscopy.


RESULTS
Newly generated bone was observed at 1 and 3 months of healing. Although bone was also generated without BG, newly mineralized bone was generated sooner with BG present for guided bone augmentation than without BG. At 1 and 3 months, the BG was not bioabsorbed completely, and some particles remained.


CONCLUSIONS
New bone is generated at an early stage of bone formation using BG for bone augmentation.
Nishida
Tetsuya
T
Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. nishida@dent.nihon-u.ac.jp
Yamada
Yutaka
Y
Murai
Masakazu
M
Shimizu
Yuka
Y
Oshikawa
Maiko
M
Ito
Koichi
K
D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics; D005898:Glass; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D010294:Parietal Bone / Q000187:drug effects*; D011817:Rabbits; D014025:Titanium / Q000627:therapeutic use
D018786:Bone Substitutes; C425330:bioactive glass 45S5; D014025:Titanium