Outcome prediction of enteral levodopa/carbidopa infusion in advanced Parkinson's disease.
Two studies comparing intraduodenal infusion of a levodopa/carbidopa gel with oral treatments in advanced PD patients demonstrated improvement in UPDRS scores and in frequent clinical ratings on a global treatment response scale. Further analysis of data from these studies was performed to find predictive factors related to degree of improvement with infusion. Pearson's correlation coefficients between measures of improvement and baseline variables were calculated. Using data from one study, a prediction model was designed and was then evaluated using the other study's data. Correlations were found indicating that patients with more severe symptoms at baseline were most improved after infusion.
Westin
J
J
Department of Medical Sciences, Biomedical Informatics and Engineering, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. jwe@du.se
Nyholm
D
D
Groth
T
T
Dougherty
M S
MS
Yerramsetty
P K
PK
Palhagen
S E
SE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002230:Carbidopa / Q000008:administration & dosage*; D015259:Dopamine Agents / Q000008:administration & dosage*; D004333:Drug Administration Routes; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D015259:Dopamine Agents; D007980:Levodopa; D002230:Carbidopa