[AIDS epidemic trends after the introduction of antiretroviral therapy in Brazil].
OBJECTIVE
Universal access to antiretroviral (ARV) therapy starting from 1996 has changed HIV/AIDS epidemic profile in Brazil. The objective of this study was to review the epidemiology of HIV/AIDS epidemic in Brazil.


METHODS
Indicators of temporal trends were developed for Brazilian regions from 1990 to 2003 using the Ministry of Health's databases. Exponential regression models adjusted to the 1990-1996 trends were used to estimate expected values for the entire period.


RESULTS
The proportion of AIDS hospitalizations has not changed over the study period but there was a decrease in hospitalizations among those using ARV therapy. There was a 2.7 growth in those receiving ARV therapy from 1997 to 2003. HIV/AIDS incidence and mortality rates rose up to 1995 in all regions. From 1996, there has been a gradual reduction in mortality rates while incidence rates have increased. In all regions, except in the Northern region, expected incidence rates have been greater than the observed ones in the last years but these differences were statistically significant only in the Southeastern and Midwestern regions.


CONCLUSIONS
The observed trend can be explained by universal access to ARV therapy in Brazil, which had a significant impact on HIV/AIDS mortality. But other factors, such as years of epidemic, prevention actions, knowledge on HIV/AIDS, years of schooling, need to be considered as well.
Dourado
Inês
I
Instituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama s/n Campus do Canela, 40110-140 Salvador, BA, Brazil. maines@ufba.br
Veras
Maria Amélia de S M
MA
Barreira
Dráurio
D
de Brito
Ana Maria
AM
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006266:Health Education / Q000639:trends; D006801:Humans; D015994:Incidence; D007256:Information Systems; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution