title: IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population.
abstract: In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.
authors.affiliation: Department of Reproductive and Developmental Sciences, University of Trieste, Via dell'Istria 65/1, Trieste, Italy. segat@burlo.trieste.it
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
authors.forename: Daiana
authors.initials: D
authors.lastname: Bevilacqua
authors.forename: Michele
authors.initials: M
authors.lastname: Boniotto
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Arraes
authors.forename: Paulo R
authors.initials: PR
authors.lastname: de Souza
authors.forename: Josè L
authors.initials: JL
authors.lastname: de Lima Filho
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D001938:Brazil; D002648:Child; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011153:Population / Q000235:genetics; D011401:Promoter Regions, Genetic
chemical_list: D020382:Interleukin-18