title: [Rhinosinusitis: etiopathogenesis and antimicrobial therapy, an update].
abstract: The aim of the current study is to underline once again the etiopathogenetic aspects of rhinosinusitis, by a revision of most significative and updated study in otorhinolaryngologic literature to guide the right management of this disease. The focal role of ostio-meatal complex is reported; epidemiological data on old and emergent pathogens are described together with their role on acute or chronic or recurrent rhinosinusitis pathogenesis. According to recent evidence based medicine documents, diagnostic criteria and methodologies are reported to control surgical and medical long-term results. On the bases of the current etiopathogenetic concepts, medical treatment is suggested. The central role of medical management is based on the choice of antimicrobial treatment. The fundamental concepts on pharmacocinetic and pharmacodinamic are reported, togther with updated data on antimicrobial resistance.
authors.affiliation: Dipartimento di Discipline Otorinolaringologiche, Università degli Studi di Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Benedetto
authors.forename: L
authors.initials: L
authors.lastname: Salerni
authors.forename: L
authors.initials: L
authors.lastname: De Benedetto
authors.forename: G C
authors.initials: GC
authors.lastname: Passali
authors.forename: D
authors.initials: D
authors.lastname: Passali
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001372:Aza Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002648:Child; D004352:Drug Resistance, Microbial; D004724:Endoscopy; D024841:Fluoroquinolones; D006801:Humans; D000077266:Moxifloxacin; D009079:Mucociliary Clearance; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000627:therapeutic use; D015242:Ofloxacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D015995:Prevalence; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D012306:Risk; D012852:Sinusitis / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D014663:Nasal Decongestants; D011804:Quinolines; D015242:Ofloxacin; D000077266:Moxifloxacin