title: [Transcranial electrical stimulation activates the reparative regeneration and insulin-producing function of beta-cells in alloxan-induced diabetic rats].
abstract: In alloxan-induced diabetic rats, it was demonstrated that transcranial electrical stimulation of the brain endorphinergic structures activated the reparative regeneration of the damaged beta-cells of the Langerhans pancreatic islets. This was estimated on the histological sections of pancreas with hematoxylin-eosin staining. Several small newborn islets were found to originate from pancreatic progenitor cells. After transcranial electrical stimulation of insulin granules, beta-cells (Gomori's staining) were observed as an indication of the restoration of the insulin production. Correspondingly the increase of the blood insulin level was estimated by immune-enzyme method. The dynamics of the plasma insulin increase had a significant negative correlation with decrease of the blood glucose level. The glucose-lowering action of the transcranial electrical stimulation in alloxan-induced diabetic rats seems to be based on stimulation of the regeneration of damaged beta-cells with the restoration of their insulin production.
authors.forename: V P
authors.initials: VP
authors.lastname: Lebedev
authors.forename: S V
authors.initials: SV
authors.lastname: Bilichenko
authors.forename: N E
authors.initials: NE
authors.lastname: Ordian
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: S P
authors.initials: SP
authors.lastname: Nechiporenko
authors.forename: A A
authors.initials: AA
authors.lastname: Puzyrev
authors.forename: E A
authors.initials: EA
authors.lastname: Mikheeva
authors.forename: K K
authors.initials: KK
authors.lastname: Kubacheva
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002540:Cerebral Cortex; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004558:Electric Stimulation; D007328:Insulin / Q000097:blood*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan