title: FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp. No. 22210 and tolypocladium parasiticum No. 16616.
abstract: Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These compounds have the same cyclic peptide nuclear structure as FR901379, with different side chains, and showed antifungal activity against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kanasaki
authors.forename: Motoo
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujine
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sato
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Seiji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hori
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000145:classification* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; C511078:FR 190293; C511077:FR 227673; D008074:Lipoproteins; D010456:Peptides, Cyclic