title: Sustained attention deficits in manic and euthymic patients with bipolar disorder.
abstract: Sustained attention deficits are proposed to be both state and trait indicators of bipolar disorder. The nature of these deficits and their association with medication and symptoms is not clear yet. The aim of this study was to investigate the impairments in various components of sustained attention task in euthymic and manic patients and was to investigate the relationship between the deficits in the manic state and medication effects. The performances of 37 manic patients, 34 euthymic patients with bipolar disorder and 34 control subjects on eight scores from Conners' CPT II, reflecting three different dimensions of sustained attention were compared. Similar to some recent findings, euthymic patients had decreased target sensitivity (omission errors) and response time inconsistency. The increased false responding (commission errors), perseveration and vigilance deficits were prominent in the manic patients. These state dependent impairments could not be explained by the impact of medication. In contrast, the exacerbation of seemingly trait-related impairments in the manic state can be at least partly explained by the impact of pharmacological therapy.
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne, Australia. emrebora@hotmail.com
authors.forename: Emre
authors.initials: E
authors.lastname: Bora
authors.forename: Simavi
authors.initials: S
authors.lastname: Vahip
authors.forename: Fisun
authors.initials: F
authors.lastname: Akdeniz
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001143:Arousal / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000523:psychology*; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D002220:Carbamazepine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D002220:Carbamazepine; D014635:Valproic Acid; D008094:Lithium