title: Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study Group.
abstract: The International COX-2 Study Group, a panel of independent physicians and scientists, convened January 28-30, 2005, in Washington, DC, to discuss the issues concerning the cardiovascular (CV) profile of coxibs. The purpose of the meeting was to review potential mechanisms by which inhibition of COX-2 by selective and nonselective NSAID could increase risk of CV events, to evaluate the similarities and differences between drugs based on mechanism and pharmacology, and to propose potential trial methodology to more definitively answer questions regarding cardiovascular risk.
authors.affiliation: Center for the Advancement of Women's Health, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Crofford
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Breyer
authors.forename: C Vibeke
authors.initials: CV
authors.lastname: Strand
authors.forename: Frank
authors.initials: F
authors.lastname: Rushitzka
authors.forename: Kay
authors.initials: K
authors.lastname: Brune
authors.forename: Michael E
authors.initials: ME
authors.lastname: Farkouh
authors.forename: Lee S
authors.initials: LS
authors.lastname: Simon
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D006801:Humans; D007391:International Cooperation; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D012219:Rheumatology / Q000379:methods
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human