title: Depression and osteoporosis in men: association or casual link?
abstract: The longer life expectancy of women than that of men and, therefore, the longer exposure to fracture risk has, at least partially, led to neglect of osteoporosis in men. Recently, unipolar depression, which is 2 times more frequent in women than in men, has been linked to osteoporosis. However, it is quite possible that this diagnosis may escape detection in men because of a different behavioral phenotype between the genders. A potential mechanism of bone loss in depression has been proposed, involving concurrent activation of the hypothalamo-pituitary-adrenal and sympatho-adrenal axes, suppression of the gonadal and somatotrophic axes, and high interleukin-6 and low leptin levels. We suggest that similar neurohormonal changes may cause osteoporosis in men.
authors.affiliation: Department of Pharmacology, Patras University Medical School, Rion-Patras, Greece. iliasi@upatras.gr
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ilias
authors.forename: Salvatore
authors.initials: S
authors.lastname: Alesci
authors.forename: Philip W
authors.initials: PW
authors.lastname: Gold
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000311:Adrenal Glands / Q000503:physiopathology; D000328:Adult; D000368:Aged; D015519:Bone Density; D003863:Depression / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D015850:Interleukin-6 / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008297:Male; D010024:Osteoporosis / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D010902:Pituitary Gland / Q000503:physiopathology; D012727:Sex Characteristics; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D015850:Interleukin-6; D020738:Leptin