title: Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin.
abstract: Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.
authors.affiliation: Department of Pediatrics, University of Tennessee Health Science Center, 38103, USA. kenglish@utmem.edu
authors.forename: B Keith
authors.initials: BK
authors.lastname: English
authors.forename: Erik M
authors.initials: EM
authors.lastname: Maryniw
authors.forename: Ajay J
authors.initials: AJ
authors.lastname: Talati
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Meals
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D015169:Colony Count, Microbial / Q000706:statistics & numerical data; D017576:Daptomycin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016106:Methicillin Resistance; D051379:Mice; D008826:Microbial Sensitivity Tests; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis; D010068:Oxacillin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha; D014640:Vancomycin; D052247:Nitric Oxide Synthase Type II; D017576:Daptomycin; D010068:Oxacillin