Outcomes of Kimura's disease after radiotherapy or nonradiotherapeutic treatment modalities.
OBJECTIVE
To evaluate the clinical outcome of Kimura's disease and to identify the optimal treatment regimen for Kimura's disease.


METHODS
Between 1984 and 2003, 14 patients with Kimura's disease were treated with radiotherapy (RT) and 9 patients were treated with local excision or systemic steroids. The radiation doses ranged from 20 to 45 Gy. Immunohistochemical studies were performed in 13 cases.


RESULTS
At RT completion, a marked response in terms of tumor size was noted in most cases. The median follow-up was 65 months. Local control was obtained in 9 (64.3%) of the 14 in the RT group and in 2 (22.2%) of the 9 in the non-RT group. No secondary malignancies were observed in the RT group.


CONCLUSIONS
These results supports the finding that RT is more effective against Kimura's disease. Simple or immunohistochemical features did not influence the treatment outcome.
Chang
Ah Ram
AR
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Hospital, Republic of Korea.
Kim
Kyubo
K
Kim
Hak Jae
HJ
Kim
Il Han
IH
Park
Charn Il
CI
Jun
Yoon Kyung
YK
D000293:Adolescent; D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012074:Remission Induction; D016896:Treatment Outcome
D005938:Glucocorticoids; D011239:Prednisolone