[Familial occurrence of diprosopus in German Holstein calves].
Diprosopus was diagnosed in six German Holstein calves born on different dairy farms. The degree of facial duplication varied from a partial doubling of the nostrils and upper jaw to complete duplication of the face with formation of two mouths, four eyes and four ears. Further calves descending from the same parents or dams and calves from the same farms were not affected. A joint pedigree was ascertained for the calves with diprosopus. Furthermore, a previously reported case of diprosopus could be traced back to the same ancestors of this pedigree. Consequently, we detected the first time a familial accumulation of diprosopus. Since the ancestors showed no signs of diprosopus and the frequency of diprosopus in German Holsteins is presumably low, an oligogenic inheritance is likely. Recessive genes or a combination of recessive and dominant genes may cause this anomaly.
Schulze
Ursula
U
Institut für Tierzucht und Vererbungsforschung, Stiftung Tierärztliche Hochschule Hannover.
Kuiper
Heidi
H
Doeleke
Renate
R
Ulrich
Reiner
R
Gerdwilker
Axel
A
Distl
Ottmar
O
D000818:Animals; D000831:Animals, Newborn; D002417:Cattle / Q000002:abnormalities* / Q000235:genetics; D002418:Cattle Diseases / Q000145:classification / Q000151:congenital / Q000235:genetics*; D019465:Craniofacial Abnormalities / Q000145:classification / Q000235:genetics / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D006257:Head / Q000002:abnormalities*; D007621:Karyotyping / Q000662:veterinary; D008297:Male; D010375:Pedigree