Do mares possess an intracellular endometrial inhibitor of prostaglandin synthesis during early pregnancy?
Cytosol was prepared from endometrium collected from pregnant or nonpregnant mares 14 d after ovulation and was added to a prostaglandin-generating system (bovine fetal cotyledonary microsomes). Addition of endometrial cytosol from pregnant mares suppressed microsomal synthesis of prostaglandin F, but addition of endometrial cytosol from nonpregnant mares increased microsomal synthesis of prostaglandin F. The results suggest that mares possess an intracellular inhibitor of prostaglandin F synthesis during early pregnancy.
Watson
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Section of Reproductive Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA.