title: Placement of the Bravo wireless pH monitoring capsule onto the gastric wall under endoscopic guidance.
abstract: BACKGROUND
  The Bravo system was designed mainly to monitor esophageal pH, and there have been no reports on gastric pH monitoring using this system.
  
  
  OBJECTIVE
  To place the Bravo capsule on the gastric wall and monitor gastric pH.
  
  
  METHODS
  Experimental clinical trial with the cooperation of volunteers.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Eleven volunteers (9 men, 2 women; mean age 38 years; 3 had symptoms of GERD).
  
  
  METHODS
  The Bravo system was introduced into the esophagus and stomach along a thin endoscope and capsules were attached, one each to the esophageal and gastric walls under direct vision through the endoscope. Esophageal and gastric pHs were simultaneously monitored.
  
  
  RESULTS
  The 2 capsules were successfully placed in 10 of the 11 subjects, and both esophageal and gastric pHs were monitored for 48 hours in 9 subjects. Mild to moderate precordial pain was observed in 7 subjects, but no other complications or side effects were observed in this study. The gastric pH of 10 subjects increased after meals and returned to baseline pH 2 hours later. Decrease of esophageal pH was observed 1 hour after a meal in the symptomatic subjects and corresponded to the time when gastric pH decreased secondary to the increase of pH with meals.
  
  
  CONCLUSIONS
  The Bravo capsule is easily placed on the gastric wall under endoscopic assistance and enables long ambulatory monitoring of gastric pH.
authors.affiliation: Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Taketo
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Ayaka
authors.initials: A
authors.lastname: Seza
authors.forename: Takeo
authors.initials: T
authors.lastname: Odaka
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Shishido
authors.forename: Masato
authors.initials: M
authors.lastname: Ai
authors.forename: Shun
authors.initials: S
authors.lastname: Gen
authors.forename: Teruo
authors.initials: T
authors.lastname: Kouzu
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Saisho
mesh_terms: D000328:Adult; D004567:Electrodes, Implanted; D016099:Endoscopy, Gastrointestinal; D004947:Esophagus / Q000502:physiology*; D005260:Female; D005750:Gastric Juice / Q000502:physiology; D005756:Gastritis / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods*; D013270:Stomach / Q000502:physiology