Global pharmacogenetics: giving the genome to the masses.
With pharmacogenetics comes the promise of individualized therapy selection for many common diseases where multiple treatment options are available. Recent advances including the Human Genome Project, the International HapMap project, advances in throughput and reduction in cost of genetic testing, and the inclusion of genotype-related dosing recommendations into package inserts all point to the integration of pharmacogenetics into clinical practice. However, many countries will not have access to pharmacogenetics resources in the near future. Generation of global genotype profiles will provide a useful, but not perfect resource for incorporating pharmacogenetics into national drug formularies in the form of prioritization or surveillance where individual genotype data would not be attainable. The PharmacoGenetics for Every Nation Initiative is a first step to making pharmacogenetics applicable on a global level.
Marsh
Sharon
S
Washington University School of Medicine, Department of Medicine, Room 1021 CSRB NT, 660 South Euclid Avenue, Campus Box 8069, St Louis, MO 63110, USA.
Van Booven
Derek J
DJ
McLeod
Howard L
HL
D004358:Drug Therapy; D005006:Ethnicity / Q000235:genetics; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends*; D011110:Polymorphism, Genetic; D014944:World Health Organization