Anti-inflammatory neolignans from Piper kadsura.
Two new neolignans, piperkadsin A (1) and piperkadsin B (2), as well as 11 known neolignans, three known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated. Compounds 1, 2, futoquinol (3), piperlactam S (4), and N-p-coumaroyl tyramine (5) showed potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 4.3 +/-1.0, 12.2 +/- 3.2, 13.1 +/- 5.3, 7.0 +/- 1.9, and 8.4 +/- 1.3 microM, respectively.
Lin
Lie-Chwen
LC
National Research Institute of Chinese Medicine, Taiwan, Republic of China. lclin@nricm.edu.tw
Shen
Chien-Chang
CC
Shen
Yuh-Chiang
YC
Tsai
Tung-Hu
TH
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013624:Taiwan; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017705:Lignans; D017382:Reactive Oxygen Species; C511673:piperkadsin A; C511674:piperkadsin B; D013755:Tetradecanoylphorbol Acetate