title: Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii.
abstract: A phytochemical investigation of the constituents of the roots of Vismia laurentii has resulted in the isolation of two xanthone derivatives named laurentixanthone A (1) (6-hydroxy-3,3-dimethyl-11-(3-methylbut-2-enyl)pyrano[2,3-c]xanthen-7(3H)-one) and laurentixanthone B (2) (1-hydroxy-5,6,7,8-tetramethoxyxanthone), along with 11 known compounds: 1,7-dihydroxyxanthone, vismiaquinone, vismiaquinone B, bivismiaquinone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone, O(1)-demethyl-3',4'-deoxypsorospermin-3',4'-diol, 6-deoxyisojacareubin, 1,8-dihydroxy-6-methoxy-3-methylanthraquinone, kaempferol, friedelin and stigmasterol. The structures of compounds were established by means of spectroscopic methods. Furthermore, the compounds were screened for antimicrobial activities in vitro.
authors.affiliation: Department of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Jean Robert
authors.initials: JR
authors.lastname: Nguemeving
authors.forename: Anatole Guy Blaise
authors.initials: AG
authors.lastname: Azebaze
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Nono Nono
authors.initials: NN
authors.lastname: Eric Carly
authors.forename: Véronique Penlap
authors.initials: VP
authors.lastname: Beng
authors.forename: Michèle
authors.initials: M
authors.lastname: Meyer
authors.forename: Alain
authors.initials: A
authors.lastname: Blond
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
authors.forename: Augustin Ephrem
authors.initials: AE
authors.lastname: Nkengfack
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014966:Xanthenes; D044004:Xanthones; C514269:laurentixanthone A; C514270:laurentixanthone B