title: Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity.
abstract: The ligands (Bpy-H, 5) have been designed to connect the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It has been revealed that the new Hoechst ligand long Bpy-H (5L) having a long linker exhibits Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a selective manner depending on the length of the linker of the ligand as well as on the distance between the two A(3)T(3) sites of DNA. [reaction: see text]
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Mikimasa
authors.initials: M
authors.lastname: Tanada
authors.forename: Saori
authors.initials: S
authors.lastname: Tsujita
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Kataoka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001562:Benzimidazoles; D008024:Ligands; C447680:hoechst 32258; D003300:Copper; D004247:DNA