Hyperbaric oxygen treatment decreases inflammation and mechanical hypersensitivity in an animal model of inflammatory pain.
Hyperbaric oxygen therapy has been used to treat a variety of ailments from carbon monoxide poisoning to fibromyalgia. The purpose of this experiment was to explore the effect of hyperbaric oxygen treatment on carrageenan-induced inflammation and pain in rats. Hyperbaric oxygen treatment significantly decreased inflammation and pain following carrageenan injection. Clinically hyperbaric oxygen may be used in situations where NSAIDS are contraindicated or in persistent cases of inflammation.
Wilson
Hilary D
HD
University of Texas at Arlington, Department of Psychology, 501 S. Nedderman Drive, Arlington, TX 76019, USA.
Wilson
Judy R
JR
Fuchs
Perry N
PN
D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D006930:Hyperalgesia / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy*; D006931:Hyperbaric Oxygenation; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy*; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000473:pathology*; D059408:Pain Management; D010147:Pain Measurement / Q000187:drug effects; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley
D002351:Carrageenan