Cellular transcriptomics -- the next phase of endocrine expression profiling.
Transcriptome analysis, or global gene expression profiling, has become a commonly used and valuable tool in both basic and clinical endocrine research. Novel endocrine regulators have 'surfaced' and greater consideration is now given to understanding function at the level of gene networks. Recent developments have shown that the transcriptome is considerably larger and more divergently expressed than was previously thought. Endocrine cells express a great variety of coding and noncoding RNAs in a highly cell-specific manner. If further value is to be taken from this research area, then steps towards defined cellular transcriptomics must be taken. New sampling techniques that utilize novel genetic models are a key first step.
Carter
David
D
School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK. smbdac@cardiff.ac.uk
D000818:Animals; D002477:Cells / Q000378:metabolism*; D002478:Cells, Cultured; D030541:Databases, Genetic; D004702:Endocrine Glands / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends*; D006801:Humans; D008954:Models, Biological; D012313:RNA / Q000032:analysis
D012313:RNA