title: Diagnosis and treatment of Neisseria gonorrhoeae infections.
abstract: The most common site of Neisseria gonorrhoeae infection is the urogenital tract. Men with this infection may experience dysuria with penile discharge, and women may have mild vaginal mucopurulent discharge, severe pelvic pain, or no symptoms. Other N. gonorrhoeae infections include anorectal, conjunctival, pharyngeal, and ovarian/uterine. Infections that occur in the neonatal period may cause ophthalmia neonatorum. If left untreated, N. gonorrhoeae infections can disseminate to other areas of the body, which commonly causes synovium and skin infections. Disseminated gonococcal infection presents as a few skin lesions that are limited to the extremities. These legions start as papules and progress into bullae, petechiae, and necrotic lesions. The most commonly infected joints include wrists, ankles, and the joints of the hands and feet. Urogenital N. gonorrhoeae infections can be diagnosed using culture or nonculture (e.g., the nucleic acid amplification test) techniques. When multiple sites are potentially infected, culture is the only approved diagnostic test. Treatments for uncomplicated urogenital, anorectal, or pharyngeal gonococcal infections include cephalosporins and fluoroquinolones. Fluoroquinolones should not be used in patients who live in or may have contracted gonorrhea in Asia, the Pacific islands, or California, or in men who have sex with men. Gonorrhea infection should prompt physicians to test for other sexually transmitted diseases, including human immunodeficiency virus.
authors.affiliation: Department of Family Medicine, University of Tennessee College of Medicine, Chattanooga Unit, Chattanooga, Tennessee 37403, USA. karl.miller@erlanger.org
authors.forename: Karl E
authors.initials: KE
authors.lastname: Miller
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D005260:Female; D052776:Female Urogenital Diseases / Q000382:microbiology*; D006069:Gonorrhea / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007592:Joint Diseases / Q000382:microbiology; D008297:Male; D052801:Male Urogenital Diseases; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy / Q000382:microbiology; D010608:Pharyngeal Diseases / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000175:diagnosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents