title: [Long-term follow-up is indicated after surgery for a phaeochromocytoma].
abstract: Two patients presented with symptoms that suggested a recurrence of phaeochromocytoma, 17 and 14 years after a first manifestation of this disease for which they had undergone successful surgery. The first patient, a 57-year-old man, had typical symptoms of phaeochromocytoma and had recently experienced deterioration of the glycaemic control of his diabetes mellitus type 2. After initial evaluation and treatment with alpha-adrenergic blockade and propranolol, he again underwent surgery. In addition to peritoneal metastases confirmed to be caused by malignant phaeochromocytoma he also had a carcinoma of the caecum. The second patient, a 32-year-old woman, complained of headache and palpitations and had liver-enzyme disorders. Ultrasound examination revealed a tumour in the right upper abdomen and a recurrence of phaeochromocytoma was diagnosed; an intact pregnancy was also found. After a healthy son had been born by caesarian section, she underwent debulking of the large intra-abdominal lymph nodes and of two metastases in the lung. At the last follow-up she was under treatment with radioactive 123I-meta-iodobenzylguanidine (123-MIBG) because of residual metastases. Studies report recurrence ofphaeochromocytoma in 8-20% of cases, and such a recurrence may be either benign or malignant. Factors predictive for recurrence are older age, a malignant primary tumour, tumour weight above 60 g, extra-adrenal origin of the tumour and peroperative tumour spill. Long-term follow-up of patients is indicated, even after successful initial surgery.
authors.affiliation: Universitair Medisch Centrum Groningen/l Rijksuniversiteit Groningen, Postbus 30.001, 9700 RB Groningen.
authors.forename: R R H
authors.initials: RR
authors.lastname: Nap
authors.forename: J R
authors.initials: JR
authors.lastname: Meinardi
authors.forename: G
authors.initials: G
authors.lastname: van den Berg
authors.forename: R P F
authors.initials: RP
authors.lastname: Dullaart
authors.forename: J
authors.initials: J
authors.lastname: de Vries
authors.forename: B H R
authors.initials: BH
authors.lastname: Wolffenbuttel
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010673:Pheochromocytoma / Q000601:surgery*; D011379:Prognosis; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome