[Diagnosis and treatment of primitive neuroectodermal tumors of pancreas].
OBJECTIVE
To improve the diagnosis and treatment of primitive neuroectodermal tumors (PNET) of the pancreas.


METHODS
One patient with PNET of the pancreas was reported in this article. The corresponding literatures on the diagnosis and treatment was reviewed.


RESULTS
The patient was diagnosed as pancreatic PNET by her clinical, microscopic, and immunohistochemical features as well as cytogenetic analysis after the resection of the tumor located in the uncinate process in PUMC Hospital. Radiochemotherapy was given after the operation for 8 months and no recurrence was observed. Since PNET of pancreas have no specific clinical symptoms and most patients have jaundice and/or abdominal pain, the diagnosis depended on the immunohistochemical features of positive P30/32(MIC2) and at least two of the neural markers. The cytogenetic analysis showed translocation mainly harbored the characteristic t (11; 22) (q24; q12). Since pancreatic PNET were highly aggressive, early chemotherapy, close follow-up, and immediate surgical interventions were required as early as possible.


CONCLUSIONS
PNET can occur in pancreas, and diagnosis and treatment should be made as early as possible to improve the outcome.
Sang
Xin-ting
XT
Department of Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. sangxt1963@yahoo.com
Liang
Nai-xin
NX
Mao
Yi-lei
YL
Lu
Xin
X
Yang
Zhi-ying
ZY
Zhong
Shou-xian
SX
Huang
Jie-fu
JF
D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000628:therapy