Effect of dextromethorphan on reference memory assessed in rats by a three-panel runway task.
The effects of dextromethorphan (DM, CAS 6700-34-1), a common over-the-counter cough suppressant, on the reference memory have been investigated by a three-panel runway setup in rats. This study was designed by using a repeated acquisition procedure such as a radialarm maze task or a water maze task. DM (20-40 mg/kg i.p.) produced a significant decrease in the number of errors (pushes made on the two incorrect panels of the three panel gates at four choice points) and latency. Systemically administered scopolamine (CAS 114-49-8) (1 mg/kg i.p.) impaired the performance on both parameters. DM (40 mg/kg i.p.) was effective in reversing the reference memory deficit induced by administration of scopolamine. DM acts as a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors. Our results suggest that inhibition of NMDA receptors by DM supports its potential positive properties. This finding might present an oppurtunity for the evaluation of this old antitussive drug.
Göçmez
Semil Selcen
SS
Kocaeli University, Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey.
Erden
Bekir Faruk
BF
Ulak
Güner
G
Utkan
Tijen
T
Yildiz
Füruzan
F
Gacar
Nejat
N
Mutlu
Oguz
O
D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003915:Dextromethorphan / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology
D000996:Antitussive Agents; D018727:Muscarinic Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D003915:Dextromethorphan; D012601:Scopolamine