Study on oxidative stress in patients with abdominal trauma.
Reactive oxygen species have been implicated in the etiology of multiple organ dyspepsia syndrome and infection's complications in patients with trauma. But the oxidative stress and antioxidants levels in abdominal trauma have not yet been studied. Therefore, this study was planned to measure lipid peroxidation for oxidative stress and reduced glutathione, catalase and superoxide dismutase (SOD) for antioxidant levels in plasma & heamolysate of 30 patients with abdominal trauma and 30 controls. From this study we can summarize that there was an increase in oxidative stress and decrease in antioxidant levels (causing oxidative stress) on day zero in patients with abdominal trauma. This oxidative stress on day zero was not related to the development of complications. There was no significant difference in oxidative stress between patients with solitary and multiple abdominal organ injury and also between patients with hollow viscus injury and solid organ injury on day zero. From this study, we conclude that in patients with abdominal trauma there was increase in oxidative stress and decrease in antioxidant levels on day zero.
Rana
S V
SV
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. svrana25@hotmail.com
Kashinath
D
D
Singh
G
G
Pal
R
R
Singh
R
R
D000007:Abdominal Injuries / Q000201:enzymology / Q000378:metabolism*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007677:Kidney Function Tests; D015227:Lipid Peroxidation; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D006454:Hemoglobins; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione