title: Synthesis and biological evaluation of 1beta-methylcarbapenems having cyclic thiourea moieties and their related compounds.
abstract: The synthesis of a new series of 1beta-methylcarbapenems having cyclic thiourea moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIId) having piperazine thiourea moiety showed the most potent antibacterial activity.
authors.affiliation: Hawon Pharm. Co., Seoul, South Korea.
authors.forename: T
authors.initials: T
authors.lastname: Han
authors.forename: J-H
authors.initials: JH
authors.lastname: Cho
authors.forename: C-H
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003500:Cyclization; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry*
chemical_list: C476323:1 beta-methylcarbapenem; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013890:Thiourea