[Chondrocyte mecanobiology. Application in cartilage tissue engineering].
Cartilage is a hydrated connective tissue that withstands and distributes mechanical forces within joints. Chondrocytes utilize mechanical signals to maintain cartilaginous tissue homeostasis. They regulate their metabolic activity through complex biological and biophysical interactions with the extracellular matrix (ECM). Some mechanotransduction mechanisms are known, while many others no doubt remain to be discovered. Various aspects of chondrocyte mechanobiology have been applied to tissue engineering, with the creation of replacement tissue in vitro from bioresorbable or non-bioresorbable scaffolds and harvested cells. The tissues are maintained in a near-physiologic mechanical and biochemical environment. This paper is an overview of both chondrocyte mechanobiology and cartilage tissue engineering
Stoltz
Jean François
JF
Mécanique et Ingénierie Cellulaire et Tissulaire, LEMTA UMR INPL CNRS 7563 et IFR 111 Bioingénierie, Faculté de Médecine, 54505 Vandoeuvre-lés-Nancy Cedex.
Netter
Patrick
P
Huselstein
Céline
C
de Isla
Natalia
N
Wei Yang
Jing
J
Muller
Sylvaine
S
D002358:Cartilage, Articular / Q000502:physiology; D019902:Chondrocytes / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D023822:Tissue Engineering