The 11482G >A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes.
OBJECTIVE
The aim of this study was to examine the effects of perilipin gene (PLIN) polymorphisms on weight gain with rosiglitazone treatment in patients with type 2 diabetes.


METHODS
A total of 160 type 2 diabetic patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Four single nucleotide polymorphisms (SNPs) at the PLIN locus were genotyped: PLIN 6209T>C, PLIN 11482G>A, PLIN 13041A>G, and PLIN 14995A>T.


RESULTS
Although fasting plasma glucose and HbA(1c) levels decreased; mean body weight increased significantly after rosiglitazone treatment. Among the four SNPs tested, only the PLIN 11482G>A polymorphism was associated with weight gain from rosiglitazone treatment. In addition, there was a significant difference in the increase in the body weight among the genotypes. Patients with the 11482A/A genotype showed less increase in body weight than those with other genotypes.


CONCLUSIONS
These data suggest that genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes.
Kang
Eun Seok
ES
Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-Gu, Seoul 120-752, Korea.
Cha
Bong Soo
BS
Kim
Hyeong Jin
HJ
Kim
Hae Jin
HJ
Kim
So Hun
SH
Hur
Kyu Yeon
KY
Lee
Hyun Joo
HJ
Shim
Wan Sub
WS
Ahn
Chul Woo
CW
Lee
Hyun Chul
HC
D002352:Carrier Proteins; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008875:Middle Aged; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use*; D015430:Weight Gain / Q000235:genetics*
D002352:Carrier Proteins; D017931:DNA Primers; D007004:Hypoglycemic Agents; D000070778:Perilipin-1; D010750:Phosphoproteins; D045162:Thiazolidinediones; D000077154:Rosiglitazone