Gitelman-like syndrome after cisplatin therapy: a case report and literature review.
BACKGROUND
Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use.


METHODS
A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria after cisplatin-based chemotherapy for ovarian cancer. This patient has had chronic muscle aches and fatigue and has had episodic seizure-like activity and periodic paralysis. Only thirteen other patients with similar electrolyte abnormalities have been described in the literature. This case has the longest follow-up.


CONCLUSIONS
Cisplatin can cause permanent nephrotoxicity, including Gitelman-like syndrome. This drug should be considered among the possible causes of chronic unexplained electrolyte disorders.
Panichpisal
Kessarin
K
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas, 79430-79410, USA. kessarin.panichpisal@ttuhsc.edu
Angulo-Pernett
Freddy
F
Selhi
Sharmila
S
Nugent
Kenneth M
KM
D000328:Adult; D000471:Alkalosis / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D018771:Arthralgia / Q000139:chemically induced; D002118:Calcium / Q000652:urine*; D002908:Chronic Disease; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D008275:Magnesium Deficiency / Q000097:blood / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010243:Paralysis / Q000139:chemically induced; D013577:Syndrome
D000970:Antineoplastic Agents; D002945:Cisplatin; D002118:Calcium