Control of Listeria monocytogenes virulence by 5'-untranslated RNA.
The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to post-transcriptional regulation as a result of their long 5'-untranslated region (5'-UTR). We have investigated the presence of 5'-UTRs among the other known virulence genes and genes that encode putatively virulence-associated surface proteins. Our results strongly suggest that L. monocytogenes controls many of its virulence genes by a mechanism that involves the 5'-UTR. These findings further emphasize the importance of post-transcriptional control for L. monocytogenes virulence.
Loh
Edmund
E
Department of Molecular Biology, Umeå University, S-901 87 Umeå, Sweden.
Gripenland
Jonas
J
Johansson
Jörgen
J
D020121:5' Untranslated Regions / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008089:Listeria monocytogenes / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
D020121:5' Untranslated Regions; D008565:Membrane Proteins; D037521:Virulence Factors