title: Effects of iodinated contrast media on common carotid and brachial artery blood flow and wall shear stress.
abstract: The aim of our study was to evaluate the effect of the intravenous contrast media iomeprol on wall shear stress, blood flow and vascular parameters in the common carotid and brachial artery. Thirty outpatients undergoing thoracic or abdominal spiral CT scans were studied. The internal diameter and flow velocity of the common carotid and brachial artery were evaluated by ultrasound, and blood viscosity was measured before and after low osmolality iomeprol (Iomeron 350) injection. The wall shear stress, blood flow and pulsatility index were calculated. To test the differences between groups, the Wilcoxon rank test and Mann Whitney U test were applied. Blood viscosity decreased slightly, but significantly after contrast media (4.6+/-0.7 vs. 4.5+/-0.7 mPa.s, P = 0.02). Contrarily, blood flow and wall shear stress did not change in the common carotid artery, but significantly decreased in the brachial artery (0.9+/-0.4 vs. 0.6+/-0.3 ml/s, P < 0.0001, and 41.5+/-13.9 vs. 35.3+/-11.0 dynes/cm2, P < 0.002, respectively), whereas the pulsatility index significantly increased in the brachial artery (5.0+/-3.3 vs. 7.5+/-5.3, P < 0.001). Iomeprol injection causes blood flow and wall shear stress reduction of the brachial artery; the rise in the pulsatility index suggests an increase in peripheral vascular resistance. Further investigation is needed to evaluate whether these modifications can be clinically relevant.
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Magna Graecia University, Catanzaro, Italy. irace@unicz.it
authors.forename: C
authors.initials: C
authors.lastname: Irace
authors.forename: S
authors.initials: S
authors.lastname: Tamburrini
authors.forename: S
authors.initials: S
authors.lastname: Tamburini
authors.forename: B
authors.initials: B
authors.lastname: Bertucci
authors.forename: M S
authors.initials: MS
authors.lastname: De Franceschi
authors.forename: A
authors.initials: A
authors.lastname: Gnasso
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects*; D017536:Carotid Artery, Common / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000187:drug effects; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol