title: [In vitro chromosome aberration test and in vivo micronucleus test of Ca-type Garcinia extract].
abstract: The induction of chromosome aberration of Ca-type Garcinia cambogia extract containing about 65% (-)-hydroxycitric acid was investigated by use of the chromosome aberration test in cultured Chinese hamster lung cells (CHL/IU) and the micronucleus test in mice. In the chromosome aberration test, Ca-type Garcinia cambogia extract did not increase the number of cells with structural aberration and/or numerical aberrations. The micronucleus test was carried out with bone marrow cells of Slc : ddY male mice after single oral administration of up to 2,000 microg/kg. There was no significant increase in the frequency of micronucleated polychromatic erythrocytes. These results indicate that Ca-type Garcinia cambogia extract does not induce chromosome aberration.
authors.affiliation: Food Development Laboratories, Nippon Shinyaku Co Ltd, Kyoto, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ono
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwakura
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000633:toxicity; D012668:Trigeminal Ganglion / Q000737:chemistry*
chemical_list: D010936:Plant Extracts