Expression of aromatase, estrogen receptors, and their coactivators in patients with endometrial cancer.
Quantitative polymerase chain reaction analysis of a panel of normal and malignant endometrial tissues revealed significant expression of both aromatase and estrogen receptor alpha in low-grade tumors, suggesting that local estrogen synthesis and action might contribute to the proliferation of these tumors.
Pathirage
Niroshani
N
Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.
Di Nezza
Lisa A
LA
Salmonsen
Lois A
LA
Jobling
Tom
T
Simpson
Evan R
ER
Clyne
Colin D
CD
D000123:Acetyltransferases / Q000378:metabolism; D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D003199:Computer Systems; D016889:Endometrial Neoplasms / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D005260:Female; D051548:Histone Acetyltransferases; D006801:Humans; D056920:Nuclear Receptor Coactivator 1; D051958:Nuclear Receptor Coactivator 2 / Q000378:metabolism; D056921:Nuclear Receptor Coactivator 3; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D051958:Nuclear Receptor Coactivator 2; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D015534:Trans-Activators; D014157:Transcription Factors; D001141:Aromatase; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; C538866:NCOA3 protein, human; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3