title: Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study.
abstract: To localize quantitative trait loci for insulin metabolism and obesity, genome scans/linkage analyses were performed on >900 members of 32 extended families participating in phase 3 of the Strong Heart Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota. Linkage analyses of fasting insulin and two obesity-related phenotypes, BMI and percent fat mass, were performed independently in each of the three populations. For log fasting insulin, we found a genome-wide maximum, robust logarithm of odds (LOD) score of 3.42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas.
authors.affiliation: Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245-0549, USA. vdiego@darwin.sfbr.org
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Diego
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dyer
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Duggirala
authors.forename: Sandra
authors.initials: S
authors.lastname: Laston
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wenger
authors.forename: Teresa
authors.initials: T
authors.lastname: Cantu
authors.forename: Bennett
authors.initials: B
authors.lastname: Dyke
authors.forename: Kari
authors.initials: K
authors.lastname: North
authors.forename: Theodore
authors.initials: T
authors.lastname: Schurr
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.forename: Richard B
authors.initials: RB
authors.lastname: Devereux
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona; D015992:Body Mass Index; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005215:Fasting / Q000097:blood; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood*; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics*; D009825:Oklahoma; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics; D013023:South Dakota
chemical_list: D007328:Insulin