title: Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration.
abstract: Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q(1) at low concentrations of 0.8 to 3.2 mug/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.
authors.affiliation: Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Inatsu
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nagata
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D010084:Oxidation-Reduction; D014451:Ubiquinone / Q000031:analogs & derivatives
chemical_list: D000975:Antioxidants; D016227:Benzoquinones; D014451:Ubiquinone; D000255:Adenosine Triphosphate; C036619:idebenone