Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE.
A case of a girl who presented at age 12 years with idiopathic cold urticaria is described. Her reactions to the cold became progressively more severe over a period of approximately 2 years, despite therapy with H1 antagonists and a type 1 receptor for cysteinyl leukotrienes receptor antagonist. She began to experience systemic symptoms on immersion in ocean water. She was atopic and had moderate persistent asthma. A trial of anti-IgE resulted in complete resolution of her urticaria and its associated manifestations. These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria.
Boyce
Joshua A
JA
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. jboyce@rics.bwh.harvard.edu
D000707:Anaphylaxis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D002648:Child; D003080:Cold Temperature / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D014581:Urticaria / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies; D007073:Immunoglobulin E