title: Heliox-driven albuterol nebulization for asthma exacerbations: an overview.
abstract: Our understanding of albuterol nebulization driven by helium-oxygen mixture (heliox) has matured with recent advances in clinical therapy, delivery systems, and understanding of dosing; this has led to substantial improvements in delivery as well as refinements of research protocols for asthma exacerbations. This review begins with heliox inhalation therapy and then addresses heliox as a driving gas for nebulization. Technical considerations are reviewed, including optimal gas mixtures, flow-rate adjustment factors, and nebulizer setup.
authors.affiliation: Division of Pediatric Emergency Medicine, Kosair Children's Hospital, University of Louisville, 571 S Floyd Street, Suite 300, Louisville, KY 40202, USA. in.kim@louisville.edu
authors.forename: In K
authors.initials: IK
authors.lastname: Kim
authors.forename: Alvin L
authors.initials: AL
authors.lastname: Saville
authors.forename: Kendra L
authors.initials: KL
authors.lastname: Sikes
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Corcoran
mesh_terms: D000328:Adult; D000335:Aerosol Propellants; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000628:therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D016503:Drug Delivery Systems; D004867:Equipment Design; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D009330:Nebulizers and Vaporizers; D010100:Oxygen / Q000627:therapeutic use*
chemical_list: D000335:Aerosol Propellants; D001993:Bronchodilator Agents; D006371:Helium; C038949:heliox; D000420:Albuterol; D010100:Oxygen