[Dependence of antimicrobial effect of micelle-capsulated therapeutics on the micelle size].
With the method of dynamic light scattering it was shown that the average size of micelles in the series of formulations based on various clindamycin salts, i. e. ClindHCl+Tween-20, ClindBz+Tween-20, ClindHCl+Cremafor-EL and ClindBz+Cremafor-EL increased from 6 to 20 nm. Investigations with the agar diffusion method revealed that the bactericidic action of the micelle-capsulated therapeutics did not depend on the micelle size within 6 to 20 mn. The concentration of the micellar clindamycin or gentamicin equal to 0.05 mcg/ml was bacteriostatic with respect to Micrococcus (Sarsina) luteus.
Chumakov
E M
EM
Khlebtsov
B N
BN
Khlebtsov
N G
NG
Chumakov
M I
MI
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002214:Capsules / Q000737:chemistry / Q000494:pharmacology; D002981:Clindamycin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005839:Gentamicins / Q000737:chemistry / Q000494:pharmacology; D008027:Light; D008823:Micelles; D010316:Particle Size; D012505:Sarcina / Q000187:drug effects; D012542:Scattering, Radiation
D000900:Anti-Bacterial Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005839:Gentamicins; D008823:Micelles; D002981:Clindamycin