The physiological regulation of uncoupling proteins.
Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.
Nicholls
David G
DG
Buck Institute for Age Research, Mitochondrial Physiology, Novato, CA 94945, USA. dnicholls@buckinstitute.org
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D015640:Ion Channel Gating; D007473:Ion Channels; D015227:Lipid Peroxidation; D008565:Membrane Proteins / Q000502:physiology*; D024101:Mitochondrial Proteins; D011522:Protons; D011685:Purine Nucleotides / Q000378:metabolism; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D005227:Fatty Acids; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011522:Protons; D011685:Purine Nucleotides; D000071256:Uncoupling Protein 1