Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.
Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.
Kahn
Jennifer Nielsen
JN
Infectious Disease Research, Merck and Co., Rahway, NJ 07065-0900, USA. jennifer_nielsen_kahn@merck.com
Hsu
Ming-Jo
MJ
Racine
Fred
F
Giacobbe
Robert
R
Motyl
Mary
M
D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification; D000077336:Caspofungin; D054714:Echinocandins; D005456:Fluorescent Dyes; D005658:Fungi / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*; D047071:beta-Glucans / Q000378:metabolism*
D000935:Antifungal Agents; D054714:Echinocandins; D005456:Fluorescent Dyes; D055666:Lipopeptides; D010456:Peptides, Cyclic; D047071:beta-Glucans; D005964:Glucosyltransferases; C040232:glucan synthase; D000077336:Caspofungin