Neurological abnormalities in caveolin-1 knock out mice.
Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control.
Trushina
Eugenia
E
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Du Charme
Jordan
J
Parisi
Joseph
J
McMurray
Cynthia T
CT
D000375:Aging / Q000502:physiology; D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000473:pathology; D051242:Caveolin 1 / Q000235:genetics*; D005298:Fertility / Q000235:genetics / Q000502:physiology; D005684:Gait; D006128:Growth / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D009410:Nerve Degeneration / Q000473:pathology; D009421:Nervous System Malformations / Q000235:genetics* / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D009929:Organ Size / Q000502:physiology; D010641:Phenotype; D016019:Survival Analysis
D051242:Caveolin 1