Porcine skin as a model system for studies of ultraviolet a effects in human skin.
The range of diagnostic and therapeutic applications of ultraviolet A (UVA) radiation has been continuously expanding. UVA radiation is a well-known mutagenic factor capable of damaging both cells and tissues. At the same time there is a very limited information on long-term consequences of irradiating the skin with different doses of UVA and long-wavelength ultraviolet B (UVB) radiation used in therapies of skin disorders. It was demonstrated that for UVA doses of 0.1 to 1000 mJ/cm2 the sensitivity of the porcine skin to the UVA-induced breaking of nuclear DNA is similar to that of the human skin. Results indicate that porcine skin may serve as a model system for population studies of the deleterious effects of UVA irradiation of the skin cells.
Brozyna
Anna
A
Department of Medical Biology, Institute of General and Molecular Biology, Nicolaus Copernicus University, Torun, Poland.
Chwirot
Barbara W
BW
D000818:Animals; D004249:DNA Damage / Q000528:radiation effects; D006801:Humans; D020287:In Situ Nick-End Labeling; D023421:Models, Animal; D012867:Skin / Q000528:radiation effects*; D013552:Swine; D014466:Ultraviolet Rays / Q000009:adverse effects*