Correlating structure with function in end-stage glaucoma.
To correlate structure and function in eyes with end-stage glaucoma.



Fifty-six eyes of 48 patients with glaucoma presenting with end-stage glaucoma underwent scanning laser polarimetry (SLP) imaging using a commercially available GDx-variable corneal compensator unit (GDx-VCC; Laser Diagnostics Technologies, Inc., San Diego, CA). End-stage glaucoma was defined by both disc appearance and standard automated perimetry visual field criteria. Standard automated perimetry parameters included: mean deviation, pattern standard deviation, and total deviation plot. GDx parameters included: TSNIT average, superior average, inferior average, TSNIT standard deviation, and nerve fiber indicator.



The visual field mean deviation was -26.75 +/- 3.50 dB. The remaining retinal nerve fiber layer measured in this group of eyes was: TSNIT average, 29.76 +/- 5.81 microm; superior average, 30.76 +/- 6.25 microm; and inferior average, 31.14 +/- 7.20 microm. A low structure-function correlation was found when analyzing separately the superior and inferior hemifields (R2 = 0.00001, R2 = 0.0016, respectively).



In eyes with end-stage glaucoma, very thin but existing retinal nerve fiber layer is found on SLP. Such values rarely dropped below 10 to 20 microm. A flattening of the GDx TSNIT pattern was seen, and the correlation between structure and function was not evident.
Blumenthal
Eytan Z
EZ
Department of Ophthalmology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Horani
Amjad
A
Sasikumar
Rajesh
R
Garudadri
Chandrasekhar
C
Udaykumar
Addepalli
A
Thomas
Ravi
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001718:Birefringence; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014794:Visual Fields / Q000502:physiology