The synthesis of tethered ligand dimers for PPARgamma-RXR protein heterodimers.
Heterodimeric compounds based on tethering the PPARgamma agonist Rosiglitazone to the RXR ligand Targretin have been prepared.
Mohler
Debra L
DL
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA. mohlerdl@jmu.edu
Shen
Gang
G
D000077610:Bexarotene; D019281:Dimerization; D008024:Ligands; D047495:PPAR gamma / Q000819:agonists* / Q000737:chemistry; D047488:Retinoid X Receptors / Q000819:agonists* / Q000737:chemistry; D000077154:Rosiglitazone; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry
D008024:Ligands; D047495:PPAR gamma; D047488:Retinoid X Receptors; D013764:Tetrahydronaphthalenes; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000077610:Bexarotene