A design for automatic preparation of highly concentrated 188Re-perrhenate solutions.
Rhenium-188 is extremely suitable for the radiotherapy of balloon dilation for the coronary artery restenosis. To satisfy the need of highly concentrated (188)Re-perrhenate for the clinical applications, we designed an apparatus to achieve the purpose of concentrating (188)Re-perrhenate solution. This apparatus comprised of a concentrator, a control box and a computer with an automatic control program. A column of cation-exchange resin in Ag(+) form and an anion-exchange column in series were used in the concentration procedure. More than 90% of (188)Re isotope in the original solution could be collected with 1mL of 0.9% NaCl solution added to collect the (188)Re adsorbed in the column in this final process (90.7+/-2.2%, n=15). We also found that the radiochemical purity in the final solution remained unchanged (100%). The designed process could automatically increase the quality and efficiency of the production of highly concentrated rhenium-188 solution, and could also reduce the radiation dose absorbed by the operator.
Luo
Tsai-Yueh
TY
Institute of Nuclear Energy Research, Taoyuan, Taiwan ROC.
Lo
Ai-Ren
AR
Hsieh
Bor-Tsung
BT
Lin
Wuu-Jyh
WJ
D002852:Chromatography, Ion Exchange / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D012211:Rhenium / Q000737:chemistry* / Q000302:isolation & purification*; D012371:Robotics / Q000295:instrumentation* / Q000379:methods; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods
D011868:Radioisotopes; D012211:Rhenium