title: [Correlation between periodontal disease and coronary atherosclerotic heart disease].
abstract: OBJECTIVE
  To investigate the correlation between coronary atherosclerotic heart disease (CAD) and periodontal disease (PD).
  
  
  METHODS
  Forty-five patients with CAD (CAD group) and 40 patients without CAD (control group) were compared with their pathological changes of periodontal tissues and inflammatory markers [high sensitive C reactive protein (hsCRP), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha)].
  
  
  RESULTS
  Univariate analysis showed that the prevalence of PD was 84.44% in CAD group and 22.50% in control group (P < 0.01). The levels of hsCRP, IL-1beta, and TNF-alpha were (5.75 +/- 1.26) mg/L, (10.32 +/- 2.96) ng/L, and (9.17 +/- 2.14) ng/L in CAD group and (1.13 +/- 0.73) mg/ L, (2.87 +/- 1.45) ng/L, and (5.84 +/- 1.96) ng/L in control group (P < 0.01). Gingival index and plaque index were statistically different between two both groups (P < 0.01). Logistic regression analysis showed that in addition to pulse pressure and low density lipoprotein cholesterol, periodontal disease index was a higher risk factor of CAD. Its relative risk was 1.217 (95% CI was 1.120-1.805, P < 0.05).
  
  
  CONCLUSIONS
  PD can cause CAD. The improvement of public oral health plays an important role in the prevention and treatment of CAD.
authors.affiliation: Department of Cardiovascular Disease, Qilu Hospital, Shandong University, Jinan 250012, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Su-jia
authors.initials: SJ
authors.lastname: Wang
authors.forename: Feng-he
authors.initials: FH
authors.lastname: Zhang
authors.forename: Pei-hui
authors.initials: PH
authors.lastname: Zheng
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications*; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000097:blood / Q000150:complications* / Q000473:pathology; D010512:Periodontal Index; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007375:Interleukin-1; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein