[Hepatocyte growth factor (HGF) in stable and unstable coronary heart disease].
Hepatocyte growth factor (HGF) is an angiogenic factor upregulated in ischaemic diseases. We measured plasma HGF concentration in 26 patients (pts) with stable angina pectoris (SAP) and 16 pts with unstable angina pectoris (UAP). HGF levels were significantly higher in pts with UAP compared with pts with SAP (p<0,01), in pts with SAP vs control group (n=38, p<0,01) and in pts with UAP vs control group (p<0,001). HGF levels in SAP group correlated with heart failure symptoms (p=0,023). There was a trend towards significance between HGF and left ventricle ejection fraction (p=0,08) and between HGF and VEGF levels in pts with SAP (p=0,08). This study demonstrates that HGF plasma levels correlates with SAP symptoms. Pts with SAP and UAP has significantly higher levels of HGF comparing with control group.
Kazberuk
Waldemar
W
Klinika Nefrologii i Chorób Wewnetrznych AM w Białymstoku. walkaz@poczta.fm
Pawlak
Krystyna
K
Myśliwiec
Michał
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor