Cellulose acetate containing toluidine blue and rose bengal is an effective antimicrobial coating when exposed to white light.
Simple methods of reducing the microbial load on surfaces in hospitals are needed to reduce the risk of hospital-associated infections. Here we report on the ability of a cellulose acetate coating containing the photosensitizers toluidine blue and rose bengal to kill microbes (Staphylococcus aureus, Escherichia coli, Clostridium difficile, a bacteriophage, and Candida albicans) on its surface when illuminated with white light.
Decraene
Valérie
V
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom.
Pratten
Jonathan
J
Wilson
Michael
M
D000890:Anti-Infective Agents; D002175:Candida / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008027:Light; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012395:Rose Bengal / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014048:Tolonium Chloride / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects
D000890:Anti-Infective Agents; D014048:Tolonium Chloride; D012395:Rose Bengal; C005062:acetylcellulose; D002482:Cellulose