[Crohn's disease and pregnancy. A descriptive and retrospective study].
OBJECTIVE
To determine the behavior of Crohn's disease during pregnancy, as well as the influence of this disease on the presence of low birthweight neonates.


METHODS
A descriptive and retrospective study of all patients with Crohn's disease followed-up in the Hospital Costa del Sol was performed. A total of 124 pregnant women were included, classified in two groups: women who became pregnant before and those who became pregnant after Crohn's disease was diagnosed. In all patients, clinical and epidemiological data, disease activity during pregnancy and in the immediate postpartum period, type of assisted delivery, and neonatal birthweight were recorded.


RESULTS
A total of 66.1% of pregnancies occurred before Crohn's disease was diagnosed, 31.5% occurred after diagnosis and 2.4% coincided with disease onset. No significant differences were found between women with and without a diagnosis of Crohn's disease in type of assisted delivery or low birthweight (p = 0.064; p = 0.643). All non-smoking patients remained in the quiescent phase and did not present disease recurrences during pregnancy. Among smokers, the disease remained inactive in 61.1%, while chronic activity or recurrences were observed in 38.9% (p = 0.003).


CONCLUSIONS
The course of inflammatory bowel disease does not adversely affect pregnancy or the immediate postpartum period, nor does it increase the presence of low birthweight neonates or the number of cesarean deliveries performed.
Ubiña-Aznar
E
E
Servicio de Aparato Digestivo, Hospital Costa del Sol, Marbella, Málaga, España. estherillaua@hotmail.com
De Sola-Earle
C
C
Rivera-Irigoin
R
R
Fernández-Moreno
N
N
Vera-Rivero
F
F
Fernández-Pérez
F
F
Navarro-Jarabo
J M
JM
García-Fernández
G
G
Moreno-Mejías
P
P
Pérez-Aisa
A
A
Perea-Milla
E
E
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001724:Birth Weight; D015331:Cohort Studies; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology*; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011644:Puerperal Disorders / Q000453:epidemiology; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013030:Spain