title: 9,11-Secosterols from the soft corals Sinularia lochmodes and Sinularia leptoclados.
abstract: Chemical investigations on the EtOAc-soluble fractions from the EtOH extract of two Formosan soft corals afforded two new 9,11-secosteroids, 3beta,11-dihydroxy-5beta,6beta-epoxy-24-methylene-9,11-secocholestan-9-one (1) and 3beta,11-dihydroxy-24-methylene-9,11-secocholestan-9-one (2), from Sinularia lochmodes and Sinularia leptoclados, respectively, along with two known analogues (3 and 4) from S. leptoclados. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those of the known compound 3. The cytotoxicity of 2-4 toward a limited panel of cancer cell lines is also reported.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Yen-Ju
authors.initials: YJ
authors.lastname: Tseng
authors.forename: Hsin-Hui
authors.initials: HH
authors.lastname: Huang
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Chung-Kuang
authors.initials: CK
authors.lastname: Lu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C511681:3beta,11-dihydroxy-24-methylene-9,11-secocholestan-9-one; C511680:3beta,11-dihydroxy-5beta,6beta-epoxy-24-methylene-9,11-secocholestan-9-one; D000970:Antineoplastic Agents; D002776:Cholestanes; D013261:Sterols