Effect of an inhibitor of prostaglandin synthesis on uterine motility in the ovariectomized ewe during induced oestrus. A preliminary report.
The myometrial electromyographic activity (EMG) of three ovariectomized ewes was studied after two consecutive treatments used for inducing oestrus: oestrogen administration and oestrogen plus an inhibitor of prostaglandin synthesis (indomethacin). The myometrial activity preceding treatments was used as a reference. The results of this study demonstrated that indomethacin modified the EMG of the myometrium recorded 24 hours after oestrogen injection. The rhythmic activity normally induced by oestrogens was suppressed, so that there was little or no difference between uterine activity recorded before and 24 hours after oestrogen injection.
Prud'homme
M J
MJ
I.N.R.A. - Station de Physiologie de la Reproduction 37380 Nouzilly France.