Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome.
In the complex regional pain syndrome (CRPS), several theories proposed the existence of pathophysiological mechanisms of central origin. Recent studies highlighted a smaller representation of the CRPS-affected hand on the primary somatosensory cortex (SI) during non-painful stimulation of the affected side. We addressed the question whether reorganizational changes can also be found in the secondary somatosensory cortex (SII). Moreover, we investigated whether cortical changes might be accompanied by perceptual changes within associated skin territories. Seventeen patients with CRPS of one upper limb without the presence of peripheral nerve injuries (type I) were subjected to functional magnetic resonance imaging (fMRI) during electrical stimulation of both index fingers (IFs) in order to assess hemodynamic signals of the IF representation in SI and SII. As a marker of tactile perception, we tested 2-point discrimination thresholds on the tip of both IFs. Cortical signals within SI and SII were significantly reduced contralateral to the CRPS-affected IF as compared to the ipsilateral side and to the representation of age- and sex-matched healthy controls. In parallel, discrimination thresholds of the CRPS-affected IF were significantly higher, giving rise to an impairment of tactile perception within the corresponding skin territory. Mean sustained, but not current pain levels were correlated with the amount of sensory impairment and the reduction in signal strength. We conclude that patterns of cortical reorganization in SI and SII seem to parallel impaired tactile discrimination. Furthermore, the amount of reorganization and tactile impairment appeared to be linked to characteristics of CRPS pain.
Pleger
Burkhard
B
Department of Neurology, BG-Kliniken Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany; University College London, UK. b.pleger@fil.ion.ucl.ac.uk
Ragert
Patrick
P
Schwenkreis
Peter
P
Förster
Ann-Freya
AF
Wilimzig
Claudia
C
Dinse
Hubert
H
Nicolas
Volkmar
V
Maier
Christoph
C
Tegenthoff
Martin
M
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D020918:Complex Regional Pain Syndromes / Q000473:pathology / Q000503:physiopathology*; D004192:Discrimination, Psychological / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006225:Hand / Q000294:innervation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D012016:Reference Values; D012684:Sensory Thresholds / Q000502:physiology; D012867:Skin / Q000294:innervation; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology; D014110:Touch / Q000502:physiology*