title: Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure.
abstract: To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. hmaochen@vip.sina.com
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
authors.forename: Zhong-Cai
authors.initials: ZC
authors.lastname: Fan
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Liu
authors.forename: Jue-Lin
authors.initials: JL
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Rao
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: De-Jia
authors.initials: DJ
authors.lastname: Huang
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000503:physiopathology*; D004317:Doxorubicin; D004594:Electrophysiology; D045164:Mesenchymal Stem Cell Transplantation; D032446:Myoblasts / Q000637:transplantation; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D004317:Doxorubicin