S-adenosylmethionine and radical-based catalysis.
S-adenosylmethionine is the major methyl donor in all living organisms, but it is also involved in many other reactions occurring through radical-based catalysis. The structure and function of some of these enzymes, including those involved in the synthesis of the molybdenum cofactors, biotin, lipoate, will be discussed.
Grillo
M A
MA
Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Università di Torino, Torino, Italy. mariaangelica.grillo@unito.it
Colombatto
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D000217:Acyltransferases / Q000737:chemistry; D000818:Animals; D001710:Biotin / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003304:Coproporphyrinogen Oxidase / Q000737:chemistry; D019281:Dimerization; D004926:Escherichia coli / Q000201:enzymology; D005609:Free Radicals; D006801:Humans; D008956:Models, Chemical; D008982:Molybdenum / Q000378:metabolism; D012264:Ribonucleotide Reductases / Q000737:chemistry; D012436:S-Adenosylmethionine / Q000378:metabolism* / Q000502:physiology*; D008063:Thioctic Acid / Q000737:chemistry
D005609:Free Radicals; D001710:Biotin; D008063:Thioctic Acid; D012436:S-Adenosylmethionine; D008982:Molybdenum; D012264:Ribonucleotide Reductases; D003304:Coproporphyrinogen Oxidase; D000217:Acyltransferases; C109735:lipoyltransferase I