[Human hepatic iron overload syndromes].
Recent advances in molecular genetics have led to a better understanding of hereditary iron overload syndromes, of which the most frequent are recessive HFE-hemochromatosis and, to a much lesser extent, dominant ferroportin disease. Acquired iron overload syndromes can be related to metabolic syndrome (insulin resistance syndrome), end-stage cirrhosis, or hematological disorders such as thalassemia and refractory anaemia.
Deugnier
Yves
Y
Service des maladies du foie et CIC Inserm 0203, CHU Pontchaillou, Rennes. Yves.deugnier@univ-rennes1.fr
D006801:Humans; D019190:Iron Overload / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D008103:Liver Cirrhosis / Q000378:metabolism