title: Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats.
abstract: The aim of this study was to investigate imipenem distribution in muscle and lung interstitial fluids of rats with Acinetobacter baumannii pulmonary infection. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.
authors.affiliation: EA 3809, Faculté de Médecine et de Pharmacie de Poitiers, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Dahyot
authors.forename: Sandrine
authors.initials: S
authors.lastname: Marchand
authors.forename: Greisiele Lorena
authors.initials: GL
authors.lastname: Pessini
authors.forename: Claudine
authors.initials: C
authors.lastname: Pariat
authors.forename: Bertrand
authors.initials: B
authors.lastname: Debaene
authors.forename: William
authors.initials: W
authors.lastname: Couet
authors.forename: Olivier
authors.initials: O
authors.lastname: Mimoz
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D045604:Extracellular Fluid / Q000378:metabolism*; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D008297:Male; D017551:Microdialysis / Q000379:methods*; D018482:Muscle, Skeletal / Q000378:metabolism*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem