SAA1 alpha/alpha alleles in amyloidosis.
BACKGROUND
Amyloidosis, mainly AA type, is one of the common diseases in nephrology clinics in Turkey. AA type amyloidosis is a complication of various chronic infections or inflammatory diseases such as familial Mediterranean fever (FMF), rheumatoid arthritis (RA), tuberculosis and bronchiectasis. A controversy exists in the literature regarding the relationship between SAA1 genotypes and AA type amyloidosis. This study aimed to investigate SAA1 gene polymorphism in different patient groups: 1) amyloidosis, 2) FMF and 3) healthy controls.


METHODS
Eighty-two patients from the three groups were included in the study: 1) amyloidosis, 2) FMF without amyloidosis, and 3) healthy controls. SAA1 genotypes were studied by the polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method.


RESULTS
The homozygous alpha/alpha genotype is the most common SAA1 genotype among patient groups with amyloidosis, and the alpha/alpha genotype frequency is significantly higher than in healthy controls (68 vs. 38%, p<0.05).


CONCLUSIONS
The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
Kelkitli
Engin
E
Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Bilgici
Birsen
B
Tokgöz
Bülent
B
Dilek
Melda
M
Bedir
Abdülkerim
A
Akpolat
Ilkser
I
Utas
Cengiz
C
Akpolat
Tekin
T
D000328:Adult; D000483:Alleles; D000686:Amyloidosis / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044466:Asian People; D010505:Familial Mediterranean Fever / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014421:Turkey; D044465:White People
D000685:Serum Amyloid A Protein