title: Evaluating the optimal activated clotting time during carotid artery stenting.
abstract: Carotid artery stenting is an alternative to carotid endarterectomy for patients at high risk for surgery for carotid artery stenosis. Although unfractionated heparin is routinely used, there are no published data evaluating the optimal activated clotting time during carotid stenting. In a retrospective analysis of 605 patients who underwent carotid stenting using unfractionated heparin at the Cleveland Clinic Foundation, the optimal peak procedural activated clotting time associated with the lowest combined incidence of death, stroke, or myocardial infarction was 250 to 299 seconds.
authors.affiliation: Vancouver General Hospital, Vancouver, British Columbia, Canada. jsaw@interchange.ubc.ca
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Saw
authors.forename: Christopher
authors.initials: C
authors.lastname: Bajzer
authors.forename: Ivan P
authors.initials: IP
authors.lastname: Casserly
authors.forename: Emilio
authors.initials: E
authors.lastname: Exaire
authors.forename: Cameron
authors.initials: C
authors.lastname: Haery
authors.forename: Ravish
authors.initials: R
authors.lastname: Sachar
authors.forename: David
authors.initials: D
authors.lastname: Lee
authors.forename: Alex
authors.initials: A
authors.lastname: Abou-Chebl
authors.forename: Jay S
authors.initials: JS
authors.lastname: Yadav
mesh_terms: D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D016893:Carotid Stenosis / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D012189:Retrospective Studies; D015607:Stents; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin