Conventional systemic agents for psoriasis. A systematic review.
Very few well designed studies have evaluated the conventional systemic agents for psoriasis. This is a systematic, evidence-based review of the literature evaluating both the efficacy and safety of the medications cyclosporine, methotrexate, acitretin, hydroxyurea, and 6-thioguanine. Treatment recommendations are made.
Strober
Bruce E
BE
New York University School of Medicine, New York, New York 10016, USA. Strober@nyc.rr.com
Siu
Kimberly
K
Menon
Kavi
K
D017255:Acitretin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011565:Psoriasis / Q000188:drug therapy* / Q000503:physiopathology; D013866:Thioguanine / Q000627:therapeutic use*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D013866:Thioguanine; D017255:Acitretin; D006918:Hydroxyurea; D008727:Methotrexate