title: [Presence of leptin in mammalian colostrum and milk and in artificial milk formulas].
abstract: Leptin is a 167-amino acid protein, involved in the regulation of adipose tissue, food intake and body weight in humans and animals. Recently, leptin synthesis has been found in the placenta and mammary glands in human and numerous animal species suggesting a role in controlling growth of the foetus and neonate. Colostrum and milk contain high amounts of leptin, in particular during the first few days of lactation. Milk leptin is associated with milk fats what may affect the results of analysis. In humans, a correlation was found between the milk leptin and plasma leptin, body weight and body mass index. In sows, no correlation have been found between the concentration of leptin in blood plasma and milk during the first week of lactation. Milk replacer formulas contain less leptin and leptin supplementation reverses the negative influence of formula feeding on the functional development of the gastro-intestinal tract in neonatal piglets. Data obtained so far suggest that breast milk leptin may control the gut development in newborns.
authors.affiliation: Zakład Fizjologii Przewodu Pokarmowego, Instytut Fizjologii i Zywienia Zwierzat im. Jana Kielanowskiego, Polska Akademia Nauk, ul. Instytucka 3, 05-110 Jabłonna, Poland. j.wolinski@ifzz.pan.pl
authors.forename: Jarosław
authors.initials: J
authors.lastname: Woliński
authors.forename: Romuald
authors.initials: R
authors.lastname: Zabielski
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003126:Colostrum / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D041943:Infant Formula; D007231:Infant, Newborn; D007774:Lactation; D020738:Leptin / Q000032:analysis*; D008892:Milk / Q000737:chemistry* / Q000378:metabolism; D008895:Milk, Human / Q000737:chemistry
chemical_list: D020738:Leptin