Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas.
Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.
Salama
Salama A
SA
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555-0587, USA.
Ho
Shu-Leong
SL
Wang
Hui-Qun
HQ
Tenhunen
Jukka
J
Tilgmann
Carola
C
Al-Hendy
Ayman
A
D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage; D006801:Humans; D007889:Leiomyoma / Q000201:enzymology*; D051381:Rats; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000201:enzymology*
D012739:Gonadal Steroid Hormones; D004958:Estradiol; D003907:Dexamethasone