Relationship of osteocalcin and matrix Gla protein gene polymorphisms to serum osteocalcin levels and bone mineral density in postmenopausal Korean women.
OBJECTIVE
To investigate the relationship of osteocalcin and matrix Gla protein (MGP) gene polymorphisms to serum osteocalcin levels, and bone mineral density (BMD) in postmenopausal Korean women.


METHODS
The osteocalcin gene Hind III and MGP gene cytosine-adenine polymorphisms were analyzed in 267 postmenopausal Korean women. Serum osteocalcin, bone alkaline phosphatase, C-telopeptide of type I collagen, and BMD at the lumbar spine and femoral neck were measured.


RESULTS
No significant differences in BMD of the lumbar spine and femoral neck were observed across MGP genotypes, whereas a significant lower BMD at the lumbar spine (but not at the femoral neck) was observed in women with the (h) allele (lower case 'h' signifies the presence of the Hind III site) in a dose-response manner. Serum osteocalcin levels among bone turnover markers studied were significantly higher in women without the 210-bp MGP (cytosine-adenine) allele, or with the osteocalcin hh genotype.


CONCLUSIONS
The osteocalcin gene Hind III polymorphism is a genetic factor that is associated with BMD of the lumbar spine in Korean women, and Gla gene polymorphisms are associated with higher osteocalcin levels.
Kim
Jung Gu
JG
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kimjg@plaza.snu.ac.kr
Ku
Seung-Yup
SY
Lee
Dong Ock
DO
Jee
Byung Chul
BC
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Moon
Shin Yong
SY
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D044466:Asian People / Q000235:genetics*; D015519:Bone Density; D016723:Bone Remodeling / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics*; D024042:Collagen Type I / Q000097:blood; D004247:DNA / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D007723:Korea; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics*; D010455:Peptides / Q000097:blood; D011110:Polymorphism, Genetic; D011859:Radiography; D000097568:Matrix Gla Protein
D000469:Alkaline Phosphatase; D002135:Calcium-Binding Proteins; D024042:Collagen Type I; D004247:DNA; D016326:Extracellular Matrix Proteins; D015675:Osteocalcin; D010455:Peptides; D000097568:Matrix Gla Protein; C052929:collagen type I trimeric cross-linked peptide