Electrochemical SNPs detection using an abasic site-containing DNA on a gold electrode.
An abasic site-containing DNA combined with lumiflavin allows amperometric determination of single nucleotide polymorphism through hydrogen bond-mediated nucleobase recognition in water by using abasic sites as a molecular recognition field.
Morita
Kotaro
K
Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
Sankaran
N B
NB
Huang
Weimin
W
Seino
Takehiro
T
Sato
Yusuke
Y
Nishizawa
Seiichi
S
Teramae
Norio
N
D020029:Base Pairing; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D005415:Flavins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006860:Hydrogen Bonding; D008024:Ligands; D020641:Polymorphism, Single Nucleotide; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D005415:Flavins; D008024:Ligands; D014867:Water; C001922:lumiflavin; D006046:Gold; D004247:DNA