Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis.
OBJECTIVE
To determine the frequency of leukotriene C4 synthase A-444C polymorphism in allergic rhinitis patients.


METHODS
A prospective, randomized, case-controlled study. Blood samples were obtained from 85 patients with allergic rhinitis and 95 healthy individuals. After the extraction of DNA from the blood samples, the leukotriene C4 synthase A-444C polymorphism was studied by a real-time polymerase chain reaction method.


RESULTS
The AC and CC genotype frequencies were statistically higher in the study group (P = 0.048 and P = 0.037, respectively). In addition, the AC polymorphism carried an increased risk of developing allergic rhinitis (odds ratio = 2.18, 95% confidence interval, 1.173-4.053, P = 0.014).


CONCLUSIONS
The C allele of the leukotriene C4 synthase gene increases the risk of developing allergic rhinitis.


CONCLUSIONS
The leukotriene C4 synthase A-444C gene polymorphism is important in susceptibility to allergic rhinitis and this is the first study of this gene polymorphism in allergic rhinitis.


METHODS
B-3b.
Eskandari
Hatice Gülçin
HG
Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey. geskandari@hotmail.com
Unal
Murat
M
Oztürk
Ozlem Görüroğlu
OG
Vayisoğlu
Yusuf
Y
Muşlu
Necati
N
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D052139:Intracellular Calcium-Sensing Proteins; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000235:genetics* / Q000378:metabolism
D052139:Intracellular Calcium-Sensing Proteins; D007073:Immunoglobulin E; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase