Profound lymphopenia and bacteraemia.
Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.
Hawkins
C A
CA
Department of Clinical Immunology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia. carolyn.hawkins@act.gov.au
Collignon
P
P
Adams
D N
DN
Bowden
F J
FJ
Cook
M C
MC
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology*; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000473:pathology
D000900:Anti-Bacterial Agents