Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.
OBJECTIVE
To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs).


RESULTS
Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7, CK20, MUC1, MUC2, MUC5AC and CD10 and were compared with 16 IPMAs. CK7 was expressed in all neoplasms. CK20 was significantly more frequent in MCAs compared with IPMAs (56.66% versus 18.75%, P = 0.027). MUC1 was more frequent in MCAs (40% versus 12.5%, P = 0.0915), whereas MUC5AC was significantly less frequent in MCAs (33.33% versus 100%). MUC2 was expressed in goblet cells of seven MCAs. In MCAs, CD10 was observed both in epithelial cells and in the ovarian-type stromal cells (24/30). Epithelial expression of CD10 was significantly lower in IPMAs (66.66% versus 6.25%, p = 0.0001).


CONCLUSIONS
MCA is characterized by a significantly greater frequency of expression of CK20 and CD10 when compared with IPMA, which preferentially expresses MUC5AC.
Handra-Luca
A
A
Service d'Anatomie Pathologique, Hôpital Beaujon, Clichy, France. adriana.handra-luca@jvr.ap-hop-paris.fr
Fléjou
J-F
JF
Rufat
P
P
Corcos
O
O
Belghiti
J
J
Ruszniewski
P
P
Degott
C
C
Bedossa
P
P
Couvelard
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D018292:Cystadenoma, Papillary / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000032:analysis; D015260:Neprilysin / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; C507499:KRT20 protein, human; D053554:Keratin-20; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins; D007633:Keratins; D015260:Neprilysin