Neurobrucellosis as an exceptional cause of transient ischemic attacks.
We report a series of four cases presented with transient ischemic attacks (TIA) or ischemic stroke as the predominant manifestation of neurobrucellosis (NB). Three of the patients were 20-28 years of age, and one patient was 53 years old. They all used to consume unpasteurized milk or its products. Two patients had systemic brucellosis in the past and received antibiotic treatment. Other causes of TIA including cardiac embolism, hypercoagulability, vascular malformations, systemic vasculitis, and infective endocarditis were excluded. NB was diagnosed with serological tests or cultures for Brucella in the cerebrospinal fluid. None of the patients had any further TIA after the initiation of specific treatment. NB should always be sought in young patients with TIA or ischemic stroke, especially if they have no risk factors for stroke and live in an endemic area for brucellosis, even if they do not have other systemic signs of brucellosis.
Bingöl
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Neurology, Ankara University School of Medicine, Ankara, Turkey.
Togay-Işikay
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C
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000382:microbiology; D002006:Brucellosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D007136:Immunoglobulins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination