Suzuki coupling of oxazoles.
A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. [reaction: see text]
Ferrer Flegeau
Emmanuel
E
University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, U.K.
Popkin
Matthew E
ME
Greaney
Michael F
MF