Importin KPNA2, NBS1, DNA repair and tumorigenesis.
During the past 20 years, the MRE11-RAD50-NBS1 complex has become an increasingly important focus in basic and clinical cancer research. One main conceptual step forward was made with the discovery of NBS1 and the understanding of its critical pathophysiological role in Nijmegen breakage syndrome. Major efforts were carried out to define the role in DNA repair of this complex. Recently, basic research has continuously extended our understanding of the complexity of the NBS1 complex. MRE11-RAD50-NBS1 complex can no longer be viewed as having a single role in DNA damage repair since it also serves as a sensor and a mediator in cell cycle checkpoint signaling. Meanwhile, studies have challenged the concept that NBS1 only functions as a tumor suppressor in preserving genome integrity in the nucleus. It may also provide an oncogenic role in the cytoplasm which is associated with the PI3-kinase/AKT-activation pathway. Consistent with this aspect, a growing body of clinical evidence suggests that NBS1 contains a deleterious character that depends on its subcellular localization. This review focuses on recent experimental evidences demonstrating how NBS1 is translocated into the nucleus by an importin KPNA2 which mediates NBS1 subcellular localization and the functions of the NBS1 complex in tumorigenesis.
Teng
Shu-Chun
SC
Department of Microbiology, College of Medicine, National Taiwan University, No. 1 Sec. 1 Jen-Ai Road, Taipei 10063, Taiwan. scteng@ha.mc.ntu.edu.tw
Wu
Kou-Juey
KJ
Tseng
Shun-Fu
SF
Wong
Chui-Wei
CW
Kao
Li
L
D021581:Active Transport, Cell Nucleus; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D049932:Nijmegen Breakage Syndrome / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D028901:alpha Karyopherins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D018797:Cell Cycle Proteins; C112156:NBN protein, human; D009687:Nuclear Proteins; D028901:alpha Karyopherins; C087978:karyopherin alpha 2