Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians.
A polymorphism in the promoter region of uncoupling protein 2 gene -866G/A has been associated with its expression levels in adipose tissue, the risk of obesity, and metabolic abnormalities. Our purpose was to examine the associations of -866G/A with body fat and the risk of metabolic syndrome in a random sample of 4018 Asians (1858 men and 2160 women) from three ethnic groups (Chinese, Malay, and Indian). The minor allele frequency of -866G/A polymorphism in South Asians was similar to that in whites. After adjustment for covariates including age, cigarette smoking, and physical activity, the -866A/A genotype was associated with higher waist-to-hip ratio as compared with the wild-type genotype in Chinese and Indian men (p = 0.018 and p = 0.046, respectively). Moreover, Indian men with -866A/A genotype had a significantly increased risk of metabolic syndrome as compared with those homozygous for the wild-type (odds ratio, 2.66; 95% confidence interval, 1.21 to 5.88; p = 0.015). Such a risk was mainly caused by the excess presence of hypertriglyceridemia and central obesity. Our findings indicate that the uncoupling protein 2 gene -866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men.
Shen
Haiqing
H
Nutrition and Genomics Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Qi
Lu
L
Tai
E Shyong
ES
Chew
Suok Kai
SK
Tan
Chee Eng
CE
Ordovas
Jose M
JM
D050154:Adiposity / Q000235:genetics*; D000328:Adult; D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000208:ethnology; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D050152:Intra-Abdominal Fat / Q000378:metabolism; D007473:Ion Channels / Q000235:genetics*; D008296:Malaysia / Q000208:ethnology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D000071246:Uncoupling Protein 2; D049629:Waist-Hip Ratio
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2