Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi.
Five new tirucallane-type saponins, sapinmusaponins F-J (1-5), were isolated from the galls of Sapindus mukorossi. The structures of these saponins were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques ((1)H-(1)H COSY, HMQC, HMBC, TOCSY, and NOESY). Compounds 1-5 showed anti-platelet-aggregation effects, but no obvious cytotoxic activity for platelets as assayed by lactate dehydrogenase (LDH) leakage. Compounds 1-5 also showed moderate activity in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay.
Huang
Hui-Chi
HC
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Tsai
Wei-Jern
WJ
Morris-Natschke
Susan L
SL
Tokuda
Harukuni
H
Lee
Kuo-Hsiung
KH
Wu
Yang-Chang
YC
Kuo
Yao-Haur
YH
D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000187:drug effects; D015394:Molecular Structure; D010941:Plant Tumors; D011817:Rabbits; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013624:Taiwan; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D012503:Saponins; D007770:L-Lactate Dehydrogenase; D013755:Tetradecanoylphorbol Acetate