title: TFIIIC boxes in the genome.
abstract: In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a barrier throughout the genome.
authors.affiliation: Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Wallrath
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Geyer
mesh_terms: D001665:Binding Sites / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D004258:DNA Polymerase III / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D016681:Genome, Fungal / Q000235:genetics*; D006570:Heterochromatin / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics; D000098832:Transcription Factor TFIIIC
chemical_list: D004268:DNA-Binding Proteins; D006570:Heterochromatin; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D004258:DNA Polymerase III