FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp. No. 22210 and tolypocladium parasiticum No. 16616.
Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These compounds have the same cyclic peptide nuclear structure as FR901379, with different side chains, and showed antifungal activity against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis.
Kanasaki
Ryuichi
R
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
Kobayashi
Motoo
M
Fujine
Kiyotaka
K
Sato
Ikuko
I
Hashimoto
Michizane
M
Takase
Shigehiro
S
Tsurumi
Yasuhisa
Y
Fujie
Akihiko
A
Hino
Motohiro
M
Hashimoto
Seiji
S
Hori
Yasuhiro
Y
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000145:classification* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; C511078:FR 190293; C511077:FR 227673; D008074:Lipoproteins; D010456:Peptides, Cyclic