title: Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia.
abstract: BACKGROUND
  Brahma (BRM) is a key component of the multisubunit SWI/SNF complex, a complex which uses the energy of ATP hydrolysis to remodel chromatin. BRM contains an N-terminal polyglutamine domain, encoded by a polymorphic trinucleotide (CAA/CAG) repeat, the only known polymorphism in the coding region of the gene (SMARCA2). We have examined the association of this polymorphism with schizophrenia in a family-based and case/control study. SMARCA2 was chosen as a candidate gene because of its specific role in developmental pathways, its high expression level in the brain and some evidence of its association with schizophrenia spectrum disorder from genome-wide linkage analysis.
  
  
  RESULTS
  Family-based analysis with 281 complete and incomplete triads showed that there is no significant preferential transmission of any of the alleles to the affected offspring. Also, in the case/control analysis, similar allele and genotype distributions were observed between affected cases (n = 289) and unaffected controls (n = 273) in each of three Caucasian populations studied: French Canadian, Tunisian and other Caucasians of European origin.
  
  
  CONCLUSIONS
  Results from our family-based and case-control association study suggest that there is no association between the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Canada. sarojini.sengupta@douglas.mcgill.ca
authors.forename: Sarojini
authors.initials: S
authors.lastname: Sengupta
authors.forename: Lan
authors.initials: L
authors.lastname: Xiong
authors.forename: Ferid
authors.initials: F
authors.lastname: Fathalli
authors.forename: Chawki
authors.initials: C
authors.lastname: Benkelfat
authors.forename: Karim
authors.initials: K
authors.lastname: Tabbane
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Danics
authors.forename: Alain
authors.initials: A
authors.lastname: Labelle
authors.forename: Samarthji
authors.initials: S
authors.lastname: Lal
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Krebs
authors.forename: Guy
authors.initials: G
authors.lastname: Rouleau
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
mesh_terms: D016022:Case-Control Studies; D005819:Genetic Markers; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D018911:Trinucleotide Repeats
chemical_list: D005819:Genetic Markers; C084011:SMARCA2 protein, human; D014157:Transcription Factors