[Prognostic value of Ki67 and VEGF in squamous cell carcinoma of larynx].
OBJECTIVE
To investigate the prognostic value of Ki67 and VEGF in squamous cell carcinoma of larynx.


METHODS
The expressions of Ki67 and VEGF in squamous cell carcinoma of larynx tissues of 32 follow-up cases were studied by immunohistochemical staining, of which five cases recurred(recurrent group), three cases metastasized (metastatic group), eight case died(deceased group) and 24 cased survived(survival group) in three years after operations.


RESULTS
The expressions of Ki67 and VEGF in deceased group were higher than those in survival group( P < 0.01). Overexpression of Ki67 could be found in recurrent group and in metastatic group (P < 0.01). And VEGF expressed higher in recurrent group than in nonrecurrent group (P < 0.05). On Cox regression of multivariate analysis, Ki67 (RR: 3.236, P < 0.01), clinical T stage (RR: 1.382, P < 0.05) and metastasis of lymph nodes (RR: 0.316, P < 0.05) were shown to be independent prognostic factors for survival of squamous cell carcinoma of larynx.


CONCLUSIONS
Ki67 and VEGF were related to the prognosis of squamous cell carcinoma of larynx, overexpression of the two markers indicated poor prognosis of the disease, and they might be helpful for the treatment of carcinoma of larynx.
Sun
Dawei
D
Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang
Yanjun
Y
Liu
Haibing
H
Kong
Weijia
W
Liu
Banghua
B
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D019394:Ki-67 Antigen; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A