title: Olfactory and gustatory disturbances caused by digitalism: a case report.
abstract: It is known that an overdose of digoxin causes visual disturbance, but the effect on the senses of smell and taste is not known. A case of olfactory and gustatory disturbance caused by digitalism is reported. In a 62-year-old male patient suffering from chronic digitalism, the serum digoxin level rose to 6.0 ng/ml. The patient was diagnosed not only with visual disturbance but also hyposmia and hypogeusia. The patient recovered from visual and chemosensory disturbances after the serum digoxin concentration returned to normal. Because the similarity of intracellular signal transduction between photoreceptor cells and olfactory and/or taste receptor cells is known, it is suspected that the influence of digoxin to chemosensory organs was caused by intermediation of sodium-potassium-adenosine triphosphatase (Na-K-ATPase) of the chemosensory receptor cells.
authors.affiliation: Department of Otolaryngology, Nanto General Hospital, 2007-5 Umeno, Nanto, Toyama, Japan. taishimaru-alg@umin.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ishimaru
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yokogawa
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000097:blood; D004077:Digoxin / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000139:chemically induced*; D013651:Taste Disorders / Q000139:chemically induced*; D014786:Vision Disorders / Q000139:chemically induced
chemical_list: D000889:Anti-Arrhythmia Agents; D004077:Digoxin