title: Concurrent chemo-radiation in the conservative management of breast cancer.
abstract: OBJECTIVE
  Sequencing of chemotherapy (CTX) with radiation (RT) in the conservative management of breast cancer (CS+RT) remains controversial. We report here the results of a retrospective analysis of all patients treated with CTX and RT, with specific focus on outcome as a function of sequencing of CTX with RT.
  
  
  METHODS
  A total of 535 patients treated with CS+RT received CTX as a component of therapy. RT was administered concurrently with CTX in 109 (CONCTX). CTX was administered before RT in 276 patients, after RT in 106 patients, and in "sandwich" fashion in 44 patients. These three groups comprise the sequential chemotherapy group (SEQCTX).
  
  
  RESULTS
  With follow-up of 8.8 years, the 10-year survival rate was 78% and the distant metastasis-free rate was 75%. Despite more adverse factors for local control, patients in the CONCTX group had superior local control rate of 92% at 10 years compared with 83% in the SEQCTX group (p < 0.001). In multivariate analysis, CONCTX was associated with a significant improvement in local control (HR = 0.338, 95% CI = 0.141-0.809, p = 0.015). Cosmetic results, toxicities, and long-term complications were acceptable using this CONCTX regimen.
  
  
  CONCLUSIONS
  CONCTX was associated with a reduction in local relapse rates, acceptable cosmesis, and toxicities. These data support the use of concurrent RT and CTX in selected patients at high risk for local failure. Future prospective trials should explore the use of concurrent CTX and RT in high-risk patients using currently employed agents.
authors.affiliation: Department of Radiation Oncology UMDNJ-Robert Wood Johnson Medical School and the Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA. hafftybg@umdnj.edu
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Haffty
authors.forename: Janet H
authors.initials: JH
authors.lastname: Kim
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Yang
authors.forename: Susan A
authors.initials: SA
authors.lastname: Higgins
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate