title: Catalytic asymmetric fluorinations.
abstract: The appearance of structurally diverse fluorinating reagents displaying a large spectrum of reactivity has been critical to the development of the catalytic asymmetric fluorination processes known to date. In this article, we discuss how this area of research emerged and which strategies have allowed for the successful development of both nucleophilic and electrophilic catalytic enantioselective fluorinations. We also present the fundamental understanding of catalytic activity and enantioselectivity for the most efficient processes and highlight the first synthetic application with the preparation of a complex fluorinated target.
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Oxford OX1 3TA, UK.
authors.forename: Carla
authors.initials: C
authors.lastname: Bobbio
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D048289:Imidazolidines / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D006845:Hydrocarbons, Fluorinated; D048289:Imidazolidines; D008670:Metals; D011392:Proline