Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin.
Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).
Huang
Hongliang
H
Institute of Immunology, Zhejiang University, Hangzhou 310031, PR China.
Tang
Guping
G
Wang
Qingqing
Q
Li
Da
D
Shen
Fenping
F
Zhou
Jun
J
Yu
Hai
H
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D008970:Molecular Weight; D011094:Polyethyleneimine / Q000737:chemistry*; D013329:Structure-Activity Relationship; D047392:beta-Cyclodextrins / Q000737:chemistry*
D003432:Cross-Linking Reagents; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011094:Polyethyleneimine; D004247:DNA