Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure.
To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart.
Chen
Mao
M
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. hmaochen@vip.sina.com
Fan
Zhong-Cai
ZC
Liu
Xiao-Jing
XJ
Deng
Jue-Lin
JL
Zhang
Li
L
Rao
Li
L
Yang
Qing
Q
Huang
De-Jia
DJ
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000503:physiopathology*; D004317:Doxorubicin; D004594:Electrophysiology; D045164:Mesenchymal Stem Cell Transplantation; D032446:Myoblasts / Q000637:transplantation; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left / Q000502:physiology*
D004317:Doxorubicin