TC1(C8orf4) is upregulated by IL-1beta/TNF-alpha and enhances proliferation of human follicular dendritic cells.
Follicular dendritic cells (FDC) play crucial roles in immune regulation. TNF-alpha has been shown to be essential to the FDC network. However, the molecular regulation of FDC proliferation has not been characterized. Here, we show that TC1(C8orf4), a novel positive regulator of the Wnt/beta-catenin pathway in vertebrates, is upregulated by IL-1beta and TNF-alpha in the human FDC-like line HK. TC1 enhances HK cell proliferation, while TC1-knockdown inhibits the proliferation induced by IL-1beta, suggesting a role of TC1 as a regulator of FDC proliferation. The regulation by pro-inflammatory cytokines suggests that TC1 might be implicated in linking local inflammation to immune response by stimulating FDC.
Kim
Youngmi
Y
Asan Institute for Life Sciences, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
Kim
Jungtae
J
Park
Juhee
J
Bang
Seunghyun
S
Jung
Yusun
Y
Choe
Jongseon
J
Song
Kyuyoung
K
Lee
Inchul
I
D001483:Base Sequence; D002460:Cell Line; D049109:Cell Proliferation; D017931:DNA Primers; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D008856:Microscopy, Fluorescence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D015854:Up-Regulation; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D017931:DNA Primers; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; C417188:RHOJ protein, human; D020741:rho GTP-Binding Proteins