Bioactive steroidal saponins from Smilax medica.
Two new spirostanol saponins ( 1 and 2) were isolated from the roots of Smilax medica, together with the known smilagenin 3-O-beta-D-glucopyranoside (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR experiments. Compounds 1 and 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs between 6.25 and 50 microg/mL) whereas 3 was inactive.
Sautour
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M
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB, UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Miyamoto
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T
Lacaille-Dubois
M-A
MA
D000935:Antifungal Agents / Q000302:isolation & purification*; D002175:Candida / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032281:Smilax / Q000737:chemistry*
D000935:Antifungal Agents; D012503:Saponins