title: [The relationship between lung function and health-related quality of life in patients with generalized myasthenia gravis].
abstract: OBJECTIVE
  To study lung function abnormalities and health-related quality of life (HRQL) in a group of patients diagnosed with generalized myasthenia gravis, and to analyze the relationship between these 2 sets of variables.
  
  
  METHODS
  In a prospective study of 20 patients diagnosed with generalized myasthenia gravis, the following parameters were measured: spirometry, static lung volumes, breathing pattern, maximal respiratory pressures, and maximum voluntary ventilation. HRQL was assessed using the 36-item short form general health questionnaire (SF-36).
  
  
  RESULTS
  The mean (SD) age of the patients was 64 (11) years. Patients were classified into 2 groups depending on whether they had IIa (12 patients) or IIb (8 patients) type disease. A small decrease in total lung capacity (86%) and slight reductions in maximal inspiratory pressure (88%) and maximum voluntary ventilation (63% in group IIb) were observed. The HRQL domains most affected were those related to physical activity and self-perceived health status in all groups, although women were more affected. The scores relating to vitality and physical activity were found to be significantly associated with forced vital capacity and lung volumes. Tidal volume was associated with maximal inspiratory and expiratory pressures, inspiratory capacity, and maximum voluntary ventilation. The respiratory rate to tidal volume ratio was inversely associated with the first three of these variables.
  
  
  CONCLUSIONS
  A very slight restrictive pattern and a reduction in inspiratory muscle strength were observed. The HRQL domains most affected were those related to physical activity and the patients' self-perceived health status. The weakness of the respiratory muscles contributes to the abnormalities observed in lung function and to the deterioration of health-related quality of life.
authors.affiliation: Departament de Pneumologia, Hospital de la Santa Creu i de Sant Pau, Facultat de Medicina. Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: G A de Freitas
authors.initials: GA
authors.lastname: Fregonezi
authors.forename: V
authors.initials: V
authors.lastname: Regiane-Resqueti
authors.forename: J
authors.initials: J
authors.lastname: Pradas
authors.forename: L
authors.initials: L
authors.lastname: Vigil
authors.forename: P
authors.initials: P
authors.lastname: Casan
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D011788:Quality of Life; D012129:Respiratory Function Tests