title: Cystatin C reference values and aging.
abstract: OBJECTIVE
  The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.
  
  
  METHODS
  The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.
  
  
  RESULTS
  CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L).
  
  
  CONCLUSIONS
  The use of CysC reference values adjusted for age should be carefully taken into consideration.
authors.affiliation: Central Laboratory of Clinical Biochemistry, Careggi Hospital, Viale Morgagni 85, 50139 Florence, Italy. ognibenea@ao-careggi.toscana.it
authors.forename: Agostino
authors.initials: A
authors.lastname: Ognibene
authors.forename: Edoardo
authors.initials: E
authors.lastname: Mannucci
authors.forename: Anna
authors.initials: A
authors.lastname: Caldini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Terreni
authors.forename: Marco
authors.initials: M
authors.lastname: Brogi
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bardini
authors.forename: Iolanda
authors.initials: I
authors.lastname: Sposato
authors.forename: Valentina
authors.initials: V
authors.lastname: Mosconi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Salvadori
authors.forename: Carlo Maria
authors.initials: CM
authors.lastname: Rotella
authors.forename: Gianni
authors.initials: G
authors.lastname: Messeri
mesh_terms: D000328:Adult; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins