A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus.
Malecki
M T
MT
Section on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Lebrun
P
P
Pezzolesi
M
M
Warram
J H
JH
Krolewski
A S
AS
Jhala
U S
US
D001665:Binding Sites; D003920:Diabetes Mellitus / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D015345:Oligonucleotide Probes; D010375:Pedigree; D011401:Promoter Regions, Genetic; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
D018398:Homeodomain Proteins; D007328:Insulin; D015345:Oligonucleotide Probes; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein