Chromatin in pluripotent embryonic stem cells and differentiation.
Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.
Meshorer
Eran
E
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. meshoree@mail.nih.gov
Misteli
Tom
T
D002454:Cell Differentiation / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D006657:Histones / Q000378:metabolism; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones