title: Rgs 2 gene polymorphisms as modulators of anxiety in humans?
abstract: Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
authors.affiliation: Laboratory of Molecular Psychiatry, Department of Psychiatry, University of Münster, Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Leygraf
authors.forename: C
authors.initials: C
authors.lastname: Hohoff
authors.forename: C
authors.initials: C
authors.lastname: Freitag
authors.forename: S A G
authors.initials: SA
authors.lastname: Willis-Owen
authors.forename: P
authors.initials: P
authors.lastname: Krakowitzky
authors.forename: J
authors.initials: J
authors.lastname: Fritze
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: B
authors.initials: B
authors.lastname: Bandelow
authors.forename: R
authors.initials: R
authors.lastname: Fimmers
authors.forename: J
authors.initials: J
authors.lastname: Flint
authors.forename: J
authors.initials: J
authors.lastname: Deckert
mesh_terms: D000379:Agoraphobia / Q000150:complications / Q000235:genetics / Q000523:psychology; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D017931:DNA Primers; D006801:Humans; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D016584:Panic Disorder / Q000235:genetics / Q000523:psychology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D020710:RGS Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D020710:RGS Proteins; C087182:RGS2 protein, human