title: Permethrin-resistant head lice (Anoplura: Pediculidae) in Argentina are susceptible to spinosad.
abstract: The insecticidal activity of spinosad was evaluated against susceptible and permethrin-resistant human lice. In a permethrin-susceptible strain of the body louse, Pediculus humanus humanus L. (Anoplura: Pediculidae), the toxicity of spinosad was similar to that established for permethrin, with an LD50 value of 1.2 ng/insect and 2.4 ng/insect, respectively. Topical application of spinosad to populations of permethrin-resistant head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), showed that susceptibility to spinosad was independent of resistance to permethrin. The effectiveness of spinosad against human lice and the low mammalian toxicity reported in the literature suggest that spinosad could be useful for the management of permethrin-resistant human lice.
authors.affiliation: Centro de Investigaciones de Plagas e Insecticidas (CITEFA- CONICET), Juan Bautista de La Salle 4397, (B1603ALO), Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Mougabure Cueto
authors.forename: E N
authors.initials: EN
authors.lastname: Zerba
authors.forename: M I
authors.initials: MI
authors.lastname: Picollo
mesh_terms: D000818:Animals; D001118:Argentina; D004338:Drug Combinations; D007305:Insecticide Resistance; D007928:Lethal Dose 50; D018942:Macrolides / Q000494:pharmacology*; D010374:Pediculus / Q000187:drug effects*; D026023:Permethrin
chemical_list: D004338:Drug Combinations; D018942:Macrolides; D026023:Permethrin; C415329:spinosad