Antimalarial activity of biflavonoids from Ochna integerrima.
During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 ( = compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1.
Ichino
Chikara
C
Kitasato Institute for Life Sciences, Kitasato University, Tokyo , Japan.
Kiyohara
Hiroaki
H
Soonthornchareonnon
Noppamas
N
Chuakul
Wongsatit
W
Ishiyama
Aki
A
Sekiguchi
Hitomi
H
Namatame
Miyuki
M
Otoguro
Kazuhiko
K
Omura
Satoshi
S
Yamada
Haruki
H
D000962:Antimalarials / Q000032:analysis*; D005419:Flavonoids / Q000737:chemistry; D043842:Ochnaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*
D000962:Antimalarials; D005419:Flavonoids