[Injections of botulinum toxin a into the detrusor vesicae for treatment of refractory detrusor hyperactivity in non-neurological patients].
OBJECTIVE
Botulinum toxin has been recognised as one of the strongest toxins since its discovery approximately 190 years ago. As the first describer, Scott performed medical therapy with botulinum-A-toxin in 1980. Since that time the spectrum of indications for the drug has increased constantly. Urologists use it, e. g., for treatment of detrusor hyperreflexia in neurogenic bladders. Several groups have evaluated the efficacy of the substance in patients with an anticholinergic-refractory detrusor hyperactivity without neurological disease.


METHODS
The present authors have analysed 16 cases with this symptoms-complex treated with intravesical botulinum-A-toxin injections.


RESULTS
No severe side effects were observed. The urodynamic parameters of the bladder were improved clearly in all patients, subjective satisfaction was reached in 72.7 %.
Neugart
F
F
Klinikum Offenburg, Klinik für Urologie und Kinderurologie, Offenburg.
Groh
R
R
Götz
T
T
Horsch
R
R
D000283:Administration, Intravesical; D000768:Anesthesia, General; D000775:Anesthesia, Spinal; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D020684:Cystoscopes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular / Q000295:instrumentation; D009122:Muscle Hypertonia / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
D019274:Botulinum Toxins, Type A