Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function.
In this issue of Cell Metabolism, Gautam et al. (2006) show that pancreatic beta cell M3 muscarinic acetylcholine receptors control insulin secretion. Their results highlight the role of the M3 receptor subtype in integrating nervous stimuli with metabolic control of insulin secretion and glucose homeostasis.
Gromada
Jesper
J
Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA.
Hughes
Thomas E
TE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology*; D043587:Receptor, Muscarinic M3 / Q000187:drug effects / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D043587:Receptor, Muscarinic M3