title: A kinetic model of oxygen regulation of cytochrome production in Escherichia coli.
abstract: Recent experimental work has identified the principal components arrayed by Escherichia coli in its sensing of, and response to, varying levels of oxygen. This apparatus may be leveraged/modified by the metabolic engineer to identify nonuniform oxygen and glucose regimens that deliver better yields than their uniform counterparts. Toward this end we build and analyse a mathematical model that captures the role played by oxygen in the regulation of cytochrome production in E. coli.
authors.affiliation: Computational and Applied Mathematics, Rice University, 6100 Main Str., MS 134, Houstin, TX 77005, USA. bpeercy@rice.edu
authors.forename: Bradford E
authors.initials: BE
authors.lastname: Peercy
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Cox
authors.forename: Sagit
authors.initials: S
authors.lastname: Shalel-Levanon
authors.forename: Ka-Yiu
authors.initials: KY
authors.lastname: San
authors.forename: George
authors.initials: G
authors.lastname: Bennett
mesh_terms: D016227:Benzoquinones / Q000378:metabolism; D019149:Bioreactors; D003580:Cytochromes / Q000096:biosynthesis*; D004789:Enzyme Activation; D004926:Escherichia coli / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption
chemical_list: D016227:Benzoquinones; D003580:Cytochromes; C004532:quinone; D005947:Glucose; D010100:Oxygen