Copper-mediated C-N bond formation via direct aminolysis of dithioacetals.
Mediated by copper acetate, an efficient approach to the C-N bond formation via direct aminolysis of dithioacetals 2 and 5 with ammonia, primary or secondary amines are developed under mild conditions. Enaminones 3 and 6 were thus obtained in high to excellent yields with high chemoselectivity. This type of aminolysis reaction presents a new synthetic application of the dithioacetal functionality. [reaction: see text]
Kang
Jing
J
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Liang
Fushun
F
Sun
Shao-Guang
SG
Liu
Qun
Q
Bi
Xi-He
XH