Palmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice.
The aim of this study was to investigate the behavioral effects of palmitone in the anti-anxiety response in experimental models in mice. In the elevated plus-maze test, palmitone (0.3, 1, 3, 10 and 30 mg/kg, I. P.) lengthened, from 50 % to 199 %, the time spent in the open arm region of the maze at all doses tested, as compared to the vehicle group ( P < 0.001). In relation to the rearing activity in the exploratory cylinder, palmitone significantly modified ( P < 0.05), in a dose-dependent manner, this activity by decreasing the number of rearings with an effective dose value (ED (50)) and 95 % confidence limits (CL (50)) of 0.79 (0.23 - 2.68) mg/kg. In addition, in the hole-board test, nose-poking was also significantly decreased ( P < 0.01) in a dose-dependent fashion [ED (50) (CL (50)) = 9.07 (4.51 - 18.26) mg/kg]. Moreover, palmitone at any dose caused no change in motor activity nor disruption in traction performance. In contrast, diazepam, used as reference drug, produced an anxiolytic effect with a significant and dose-dependent decrease in motor coordination accompanied by disruption of the traction performance. Behavioral studies suggest an anti-anxiety effect produced by palmitone, but its neuropharmacological profile differs from that observed for benzodiazepines such as diazepam.
González-Trujano
Ma Eva
ME
Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría, San Lorenzo Huipulco, México D.F., México. evag@imp.edu.mx
Martínez
Ana Laura
AL
Reyes-Ramírez
Adelfo
A
Reyes-Trejo
Benito
B
Navarrete
Andrés
A
D000818:Animals; D031041:Annona; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006838:Hydrocarbons / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007659:Ketones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D006838:Hydrocarbons; D007659:Ketones; D010936:Plant Extracts; C423862:palmitone