Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
The hexane extract of oleo-gum-resin of Boswellia serrata (BSHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The BSHE was given in two different doses (87.5 mg/kg p.o. and 175 mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of BSHE (87.5 mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of BSHE was supported by changes in histopathology. It was concluded that hexane extract of oleo-gum-resin of Boswellia serrata plant in lower doses possess hepatoprotective activity.
Y
Jyothi
J
Krupanidhi College of Pharmacy, 5, Sarjapur Road, Koramangala, Bangalore-560 034, India.
Kamath
Jagadish V
JV
Asad
Mohammed
M
D000082:Acetaminophen; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029743:Boswellia / Q000737:chemistry*; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D006586:Hexanes; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D009336:Necrosis; D009929:Organ Size; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012116:Resins, Plant / Q000494:pharmacology*; D012838:Silymarin / Q000494:pharmacology; D013853:Thioacetamide
D000893:Anti-Inflammatory Agents; D006586:Hexanes; D010936:Plant Extracts; D020011:Protective Agents; D012116:Resins, Plant; D012838:Silymarin; D013853:Thioacetamide; D000082:Acetaminophen; D002251:Carbon Tetrachloride