[Eosinophilic esophagogastroenteritis within the spectrum of food allergies].
Under normal conditions, the digestive tube immune system is capable of establishing an effective plan of tolerance to food that is eaten daily by the human beings. However, this tolerance plan sometimes fails and in the final steps of this immunological dysreaction, other cellular elements, usual residents of the digestive mucous, such as eosinophil granulocytes, generally participate, together with the main cells of this system. This is the case, among others, of the so-called EGE-Eos. The authors summarize the spectrum of pathogenic options of these immunological food intolerances that range from those in which "all" depend on a specific IgE (GI food anaphylaxis) and those others in which "nothing" depends on this reagin (celiac sprue). An intermediate position would be occupied by the EGE-Eos in which there seems to be overlapping of immune reactions of cellular character together with a certain role of the IgE. These pathogenic pathways frequently cross a tangle of cellular and molecular events that cannot be untangled with either an image or one thousand words.
Sánchez-Fayos Calabuig
P
P
Servicio de Aparato Digestivo, Fundación Jiménez Díaz, Universidad Autónoma, Madrid. palomasanchezfayos@wanadoo.es
Martín Relloso
M J
MJ
Porres Cubero
J C
JC
D015704:CD4 Antigens / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D004942:Esophagitis, Peptic / Q000453:epidemiology* / Q000276:immunology*; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D005759:Gastroenteritis / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007378:Interleukins / Q000276:immunology
D015704:CD4 Antigens; D007378:Interleukins; D007073:Immunoglobulin E