Regulation of the Wnt/beta-catenin pathway by redox signaling.
Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin pathway. This work provides interesting new insight into cross-talk between redox and Wnt/beta-catenin signaling in normal physiology and cancer.
Korswagen
Hendrik C
HC
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D019556:COS Cells; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D000072261:Dishevelled Proteins; D006861:Hydrogen Peroxide / Q000494:pharmacology; D051379:Mice; D041681:NIH 3T3 Cells; D009687:Nuclear Proteins / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction; D013879:Thioredoxins / Q000378:metabolism; D051153:Wnt Proteins / Q000037:antagonists & inhibitors*; D014981:Xenopus; D051176:beta Catenin / Q000037:antagonists & inhibitors*
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D051153:Wnt Proteins; D051176:beta Catenin; D013879:Thioredoxins; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; C105231:nucleoredoxin