Autophagy and caspase-independent cell death: p19ARF enters the game.
ARF, often localized in the nucleolus, controls the p53 pathway and ribosomal biogenesis. In a recent issue of Molecular Cell, Kimchi and colleagues describe a short mitochondrial form of ARF (smARF), produced by internal initiation of translation, that dissipates mitochondrial membrane potential independently of p53 and Bcl-2 family members and triggers caspase-independent cell death. The prodeath function of smARF is dependent on the induction of autophagy.
Codogno
Patrice
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INSERM U756, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.
D001343:Autophagy / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism; D014176:Protein Biosynthesis; D025803:Tumor Suppressor Protein p14ARF / Q000235:genetics / Q000502:physiology*
D025803:Tumor Suppressor Protein p14ARF; D020169:Caspases