title: Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
abstract: Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA. kaeber@u.washington.edu
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
authors.forename: Kristan K
authors.initials: KK
authors.lastname: Steffen
authors.forename: Di
authors.initials: D
authors.lastname: Hu
authors.forename: Nick
authors.initials: N
authors.lastname: Dang
authors.forename: Emily O
authors.initials: EO
authors.lastname: Kerr
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: Stanley
authors.initials: S
authors.lastname: Fields
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
mesh_terms: D031204:Caloric Restriction; D005947:Glucose / Q000378:metabolism; D006655:Histone Deacetylases / Q000502:physiology*; D008136:Longevity; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000502:physiology*; D056565:Sirtuin 2; D037761:Sirtuins / Q000502:physiology*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C423033:HST2 protein, S cerevisiae; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases; D005947:Glucose