title: Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems.
abstract: Tissue engineering and regenerative medicine offer solutions to a number of compelling clinical problems that have not been adequately addressed through the use of permanent replacement devices. The challenge will be to select the optimal combination of a biomaterial scaffold, cells, and soluble regulators for a particular clinical problem. For many connective tissues of the musculoskeletal system, with microstructures that reflect the mechanical environment, it may be more advantageous to regenerate the tissue (in such a way that they retain their phenotypic characteristics) and in the genetic engineering that has led to the production of growth factors and cloning of their genes.
authors.affiliation: Tissue Engineering, VA Boston Healthcare System, and Orthopaedic Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mspector@rics.bwh.harvard.edu
authors.forename: Myron
authors.initials: M
authors.lastname: Spector
mesh_terms: D001672:Biocompatible Materials; D006801:Humans; D009140:Musculoskeletal Diseases / Q000628:therapy*; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials