Quality control in self/nonself discrimination.
Unicellular eukaryotes primarily employ self/nonself discrimination to avoid self-mating, whereas multicellular organisms also use self/nonself discrimination in immune defense. Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system.
Boehm
Thomas
T
Department of Developmental Immunology, Max-Planck Institute of Immunobiology, Freiburg, Germany. boehm@immunbio.mpg.de
D000818:Animals; D005057:Eukaryotic Cells / Q000276:immunology*; D019143:Evolution, Molecular; D005658:Fungi / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007157:Immunologic Surveillance / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D010455:Peptides / Q000276:immunology; D010944:Plants / Q000276:immunology; D011946:Receptors, Antigen / Q000276:immunology*; D012098:Reproduction / Q000502:physiology
D010455:Peptides; D011946:Receptors, Antigen