[The molecular genetics of psoriasis].
The review is dedicated to molecular-and-genetic aspects of psoriasis. The paper contains a general characterization of this skin disease and a range of hypotheses concerning its appearance, clinical manifestations, and maintenance. Its autoimmune nature with the central role played by T-cells is considered to be the basic theory of the appearance of psoriasis. According to the results of analysis of experimental data on psoriasis genetics, including family background, psoriasis is defined as a complex multigene multifactor disease, whose manifestations are determined by a combination of certain genes as well as by various environmental trigger factors. The authors consider ethnic features of psoriasis, and genes that determine predisposition to the disease. Prospects of the search of predisposition genes, including analysis of the polymorphism of unit nucleotides, are outlined in the article.
Piruzian
An L
AL
Abdeev
R M
RM
D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D011565:Psoriasis / Q000235:genetics*; D012307:Risk Factors