The prognosis significance of insulin secretion in liver cirrhosis.
We evaluate the prognostic significance of chronic liver diseases followed by diabetes mellitus in 40 patients by Child class, immunoreactive insulinemia (IRI), C peptide (CP) and pancreolaury-test (PLT) at 5 years. Death and hepatic insufficiency prevalence were significantly higher in cirrhotic diabetics, and in those diabetics with a lower insulin secretion (IRI, CP). Insulin hyposecretion (lower IRI, CP) was found in cirrhotic with abnormal PLT (below 20%). The onset of diabetes mellitus in liver cirrhosis has a bad prognosis when it is caused by decreased insulin secretion produced by chronic pancreatitis or pancreatic insufficiency.
Sâmpelean
D
D
4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Leach
Nicoleta
N
Suciu
Ioana
I
D002096:C-Peptide / Q000097:blood; D003920:Diabetes Mellitus / Q000209:etiology* / Q000401:mortality; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D008137:Longitudinal Studies; D011237:Predictive Value of Tests; D011379:Prognosis
D002096:C-Peptide; D007328:Insulin