Extension of the Haseman-Elston regression model to longitudinal data.
We propose an extension to longitudinal data of the Haseman and Elston regression method for linkage analysis. The proposed model is a mixed model having several random effects. As response variable, we investigate the sibship sample mean corrected cross-product (smHE) and the BLUP-mean corrected cross product (pmHE), comparing them with the original squared difference (oHE), the overall mean corrected cross-product (rHE), and the weighted average of the squared difference and the squared mean-corrected sum (wHE). The proposed model allows for the correlation structure of longitudinal data. Also, the model can test for gene x time interaction to discover genetic variation over time. The model was applied in an analysis of the Genetic Analysis Workshop 13 (GAW13) simulated dataset for a quantitative trait simulating systolic blood pressure. Independence models did not preserve the test sizes, while the mixed models with both family and sibpair random effects tended to preserve size well.
Won
Sungho
S
Department of Epidemiology and Biostatistics, Case Western Reserve University, USA.
Elston
Robert C
RC
Park
Taesung
T
D000465:Algorithms; D003627:Data Interpretation, Statistical; D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D040641:Quantitative Trait Loci; D012044:Regression Analysis; D013997:Time Factors