title: Associations among benign prostate hypertrophy, atypical adenomatous hyperplasia and latent carcinoma of the prostate.
abstract: OBJECTIVE
  To investigate the frequency of atypical adenomatous hyperplasia (AAH) and its associations with benign prostate hypertrophy (BPH) and latent histological carcinoma of the prostate (LPC) in autopsy material.
  
  
  METHODS
  Two hundred and twelve prostate specimens obtained from autopsy material were subjected to whole mount analysis in an attempt to investigate the associations among BPH, AAH and LPC.
  
  
  RESULTS
  Most histological carcinomas and AAH lesions were found in enlarged prostates with intense hypertrophy. No statistically significant relation was found between BPH and the main characteristics of LPC, such as tumor volume, histological differentiation and biological behavior. Our data regarding multi-focal tumors showed a tendency for multi-focal carcinomas to develop in larger prostates, and a tendency of AAH lesions to develop in larger prostates. No statistically significant relation was found between AAH and LPC.
  
  
  CONCLUSIONS
  There seems not any causative aetiopathogenetical or topographical relation between AAH lesions and prostate adenocarcinoma. AAH lesion seems to be a well-defined mimicker of prostatic adenocarcinoma, and the reported association of AAH with prostatic carcinoma could probably be an epiphenomenon.
authors.affiliation: Department of Urology, University Hospital, Medical School, University of Crete, Heraklion 71110, Greece. stamatiouk@gmail.com
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stamatiou
authors.forename: Alevizos
authors.initials: A
authors.lastname: Alevizos
authors.forename: Mohamed
authors.initials: M
authors.lastname: Natzar
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mihas
authors.forename: Anargiros
authors.initials: A
authors.lastname: Mariolis
authors.forename: Emmanouel
authors.initials: E
authors.lastname: Michalodimitrakis
authors.forename: Fragiskos
authors.initials: F
authors.lastname: Sofras
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*