title: [SPECT lung perfusion scans in predicting radiation pneumonitis in lung cancer patients].
abstract: OBJECTIVE
  To evaluate single photon emission computed tomography (SPECT) lung perfusion in predicting radiation pneumonitis in lung cancer patients.
  
  
  METHODS
  From April 2003 to March 2004, 31 lung cancer patients treated with radical radiotherapy received SPECT lung perfusion scans, among whom, 23 had had perfusion scans both before and at the time of 40 Gy irradiation. The perfusion changes in the region of interest (ROI) after irradiation were obtained through comparing post-radiotherapy with pre-radiotherapy average proportion of SPECT counts within the ROI relative to average counts of the whole lung. Endpoint was defined as grade 2 and above radiation pneumonitis according to RTOG criteria.
  
  
  RESULTS
  Lung perfusion defect was observed in all the patients at baseline. > or = grade 2 lung perfusion defect was found in 68.2% (15/22) of patients with central lesion and in 22.2% (2/9) of patients with peripheral lesions (P = 0.04). Seventy percent of the patients (16/23) experienced improved perfusion at 40 - 50 Gy. > or = grade 2 radiation pneumonitis was observed in 12 patients (38.7%) in the whole group, with 6 in those with grade 1 perfusion defects and another 6 in > or = grade 2 group, respectively; Of the 23 patients who had had both pre- and post-radiotherapy SPECT perfusion scan, 5 > or = grade 2 radiation pneumonitis occurred in the 16 perfusion-improved patients and 3 in the 7 unimproved patients.
  
  
  CONCLUSIONS
  There is no significant correlation between radiation pneumonitis and the extent of perfusion defect either before or after 40 - 50 Gy irradiation based on our limited data analysis in this series.
authors.affiliation: Department of Radiation Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
authors.forename: Lu-jun
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Lü-hua
authors.initials: LH
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Qin-fu
authors.initials: QF
authors.lastname: Feng
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Guang-fei
authors.initials: GF
authors.lastname: Ou
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000503:physiopathology / Q000528:radiation effects; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011014:Pneumonia / Q000000981:diagnostic imaging* / Q000209:etiology; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000209:etiology; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods