Heme oxygenase-1 and transplantation tolerance.
Tolerance is the ultimate goal of transplantation: the lack of any need for immunosuppression with long-term survival of the transplanted tissue and a full immunological response to all antigens other than those on the transplant. In honor of my dear friend and colleague, Prof. Dr. Jon van Rood, I summarize here our work in this area making use of heme oxygenase-1 (HO-1) and the products that degradation of heme by HO-1 generates.
Bach
Fritz H
FH
Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
D000818:Animals; D001664:Biliverdine / Q000378:metabolism / Q000494:pharmacology; D002248:Carbon Monoxide / Q000378:metabolism / Q000494:pharmacology; D006084:Graft Rejection; D016027:Heart Transplantation / Q000276:immunology; D006418:Heme / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000276:immunology*; D051379:Mice; D023001:Transplantation Tolerance
D006418:Heme; D002248:Carbon Monoxide; D051547:Heme Oxygenase-1; D001664:Biliverdine