title: Failure of luteolysis leads to prolonged gestation in a bitch: a case report.
abstract: A healthy, 5-yr-old rough collie bitch exhibited prolonged gestation, characterized by intrauterine fetal death and plasma progesterone concentrations (PPC) above 6 nmol/L/d until Day 65 or 66 of cytologic diestrus, which then only dropped following treatment with dinoprost tromethamine. The bitch showed no signs of parturition prior to laparotomy and hysterotomy on Day 63, which revealed 5 corpora lutea (CL) on the left ovary and 1 on the right ovary; 5 full-term, dead conceptuses without obvious autolysis but with 4 of the 5 placentas detached; and a tightly closed cervix. All conceptuses were in the left uterine horn. Treatment with dinoprost tromethamine was initiated 1 d after hysterotomy and was continued for IO d (120 microg/kg twice daily for a total dose of 240 microg kg/d). The discharge of lochia through the cervix and lactation started 3 d after the onset of treatment. Plasma progesterone concentration was 14.4, 16.2 and 1.6 nmol/L/d on the day of hysterotomy and at 1 and 3 d after the onset of prostaglandin therapy, respectively. The reason for the failure of luteolysis to occur is not known.
authors.affiliation: Department of Theriogenology Faculty of Veterinary Science, University of Pretoria Onderstepoort, South Africa.
authors.forename: P C
authors.initials: PC
authors.lastname: Irons
authors.forename: J O
authors.initials: JO
authors.lastname: Nöthling
authors.forename: D H
authors.initials: DH
authors.lastname: Volkmann