title: Hap1 and GABA: thinking about food intake.
abstract: GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.
authors.affiliation: Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Woods
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000235:genetics / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000378:metabolism* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: C490758:Hap1 protein, mouse; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid