The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair.
DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol kappa in mammalian NER.
Ogi
Tomoo
T
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.
Lehmann
Alan R
AR
D000818:Animals; D002460:Cell Line; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000172:deficiency / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology; D007700:Kinetics; D051379:Mice; D014466:Ultraviolet Rays / Q000009:adverse effects; D000099270:Y-Family DNA Polymerases
D004259:DNA-Directed DNA Polymerase; C498613:Polk protein, mouse; D000099270:Y-Family DNA Polymerases