A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer.
A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation. After administration of granulocyte colony-stimulating factor (G-CSF), multiple infiltrative erythema was identified on the face, thigh, and lower leg. A dermatologist diagnosed this as Sweet's syndrome caused by G-CSF; consequently G-CSF administration was stopped. When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter. The patient then suffered from sudden left chest pain and dyspnea. Chest computed tomography showed the characteristic findings of septic pulmonary emboli (SPE). He was treated by the administration of vancomycin, fluconazole, and pazufloxacin mesilate. Although Sweet's syndrome and SPE are rare diseases, the presence of these diseases must be considered when performing chemotherapy for urological malignancy.
Hara
Isao
I
Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. hara@med.kobe-u.ac.jp
Miura
Tetsuya
T
Yamanaka
Kazuki
K
Tanaka
Kazushi
K
Yamada
Yuji
Y
Fujisawa
Masato
M
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D018805:Sepsis / Q000150:complications* / Q000188:drug therapy; D016463:Sweet Syndrome / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor