Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke.
Patients with Parkinson's disease have been frequently classified by their most prominent symptoms into tremor-predominant and akinetic/rigid variants. A few pathological studies have suggested that these different phenotypes represent topographical differences in nigral pathology. A patient is described in whom a medial substantia nigra stroke led to contralateral lower extremity parkinsonian tremor, providing a clinical-pathological correlation of this tremor, indicating a somatotopic organization of the substantia nigra and supporting the central generator hypothesis of parkinsonian tremor.
Gonzalez-Alegre
Pedro
P
Department of Neurology, University of Iowa College of Medicine, Iowa, USA. pedro-gonzalez-alegre@uiowa.edu
D000293:Adolescent; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010300:Parkinson Disease / Q000209:etiology* / Q000473:pathology; D020521:Stroke / Q000150:complications* / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*; D014202:Tremor / Q000503:physiopathology*