title: Pregnancy-associated plasma protein-A in patients with cerebrovascular diseases--a pilot study.
abstract: Pregnancy-associated plasma protein-A (PAPP-A) was described as a novel marker of acute coronary syndrome. The aim of our study was to investigate how serum pregnancy-associated plasma protein-A (PAPP-A) levels change in patients with ischaemic stroke and intracerebral haemorrhage and to evaluate if PAPP-A might be a marker not only of myocardial infarction but also a useful parameter in cerebrovascular disorders. 43 patients with acute cerebrovascular events were divided into 3 groups--patients with ischaemic stroke (n=16), patients with intracranial haemorrhage (n=10) and patients with both ischaemic stroke and coronary artery disease (n=17). The control group consisted of 12 subjects. PAPP-A was measured by TRACE (Time Resolved Amplified Cryptate Emission) technology. PAPP-A levels in patients with intracranial haemorrhage and those with both ischaemic stroke and coronary artery disease were increased in comparison with the control group (p<0.005, p<0.01, respectively) as well as with patients with ischaemic stroke only (p<0.01, p<0.05, respectively). A positive correlation between PAPP-A and total cholesterol in patients with both ischaemic stroke and coronary artery disease (r=0.497, p<0.05) was observed. Serum PAPP-A levels in all studied patients correlated positively with serum creatinine (r=0.395, p<0.05). PAPP-A levels are increased in patients with intracranial haemorrhage and in the patients whose ischaemic stroke is associated with coronary artery disease. The atherosclerotic process may contribute to increased serum PAPP-A levels. PAPP-A may be a marker of increased risk of atherothrombotic events in general.
authors.affiliation: Institute of Medical Biochemistry of the First Faculty of Medicine, Charles University in Prague, Czech Republic. lfial@lf1.cuni.cz
authors.forename: L
authors.initials: L
authors.lastname: Fialová
authors.forename: N
authors.initials: N
authors.lastname: Pilecková
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: J
authors.initials: J
authors.lastname: Soukupová
authors.forename: M
authors.initials: M
authors.lastname: Kalousová
authors.forename: I
authors.initials: I
authors.lastname: Malbohan
authors.forename: A
authors.initials: A
authors.lastname: Pernický
authors.forename: P
authors.initials: P
authors.lastname: Kraml
authors.forename: T
authors.initials: T
authors.lastname: Zima
mesh_terms: D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000175:diagnosis; D008297:Male; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D020521:Stroke / Q000097:blood / Q000175:diagnosis
chemical_list: D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A