Issues related to the pharmacological management of patients with brain tumours and epilepsy.
The patient affected by epilepsy related to brain tumours presents certain features linked to the summation of his cancer-related problems and his epilepsy-related problems. Furthermore, epilepsy in brain tumour patients is often refractory to pharmacological treatments and can complicate the therapeutic management of these patients due to the increased incidence of pharmacological interactions and adverse effects. Analysis of the data in the literature suggests that it is opportune, when planning antiepileptic therapy in these cases, to choose the new-generation drugs, as these show a lower incidence of pharmacological interactions with the therapies used in brain tumour patients (chemotherapies, radiotherapy and support therapies), have fewer adverse effects, and have less impact on neuropsychological functions, all factors that strongly influence the patient's quality of life. Of the new antiepileptic drugs, the following seem to be promising in the treatment of cancer-related epilepsy: oxcarbazepine, topiramate and levetiracetam (the latter as an add-on therapy). The pharmacokinetic features of these drugs, their effectiveness in controlling seizures, and the reduced incidence of adverse effects make them useful in this particular group of patients.
Maschio
Marta
M
Epilepsy Outpatient Centre, Department of Neuroscience and Cervical-Facial Pathology, Regina Elena National Cancer Institute, Rome, Italy. maschio@ifo.it
Dinapoli
Loredana
L
Zarabia
Alessia
A
Jandolo
Bruno
B
D000927:Anticonvulsants / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D006801:Humans
D000927:Anticonvulsants