Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus.
A new cytotoxic compound, pterocidin, was isolated from the endophytic Streptomyces hygroscopicus TP-A0451, and the structure was determined on the basis of spectroscopic data. Pterocidin showed cytotoxicity against some human cancer cell lines with IC50 values of 2.9-7.1 microM.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University, Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
Miura
Shin-Suke
SS
Fujita
Tsuyoshi
T
Furumai
Tamotsu
T
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D011753:Pyrones; C511081:pterocidin