Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia.
The chemokine MCP-1 is thought to play a key role - among many other pathophysiological processes - in myocardial infarction. MCP-1 is not only a key attractant for monocytes and macrophages and as such responsible for inflammation but might also be directly involved in the modulation of repair processes in the heart. We show that cultured human cardiac cells express MCP-1 and that its expression is upregulated by inflammatory cytokines and downregulated by hypoxia. We hypothesize that inflammation but not hypoxia is the main trigger for monocyte recruitment in the human heart.
Hohensinner
Philipp J
PJ
Department of Internal Medicine II, Medical, University of Vienna, Austria.
Kaun
Christoph
C
Rychli
Kathrin
K
Ben-Tal Cohen
Enbal
E
Kastl
Stefan P
SP
Demyanets
Svitlana
S
Pfaffenberger
Stefan
S
Speidl
Walter S
WS
Rega
Gersina
G
Ullrich
Robert
R
Maurer
Gerald
G
Huber
Kurt
K
Wojta
Johann
J
D015687:Cell Hypoxia / Q000502:physiology*; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018932:Chemokine CCL2; D018836:Inflammation Mediators