[Functional interactions between the TGF-beta signaling pathway via the Smads and TNF-alpha: implications for the regulation of type I collagen expression].
The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. Its also represents the most crucial element governing the process of tissue repair. TGF-beta, a key player in the physiopathology of tissue repair, enhances type I collagene gene expression. In contrast, TNF-alpha, whose matrix-remodelling function is opposite to that of TGF-beta, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-beta and TNF-alpha, and on the molecular mechanisms that control the antagonistic activity of TNF-alpha against TGF-beta-driven type I collagen gene expression.
Verrecchia
Franck
F
INSERM U697, Hôpital Saint-Louis, Pavillon Bazin, 1, avenue Claude Vellefaux, 75010 Paris. franck.verrecchia@stlouis.inserm.fr
D000818:Animals; D003094:Collagen / Q000096:biosynthesis* / Q000235:genetics; D024042:Collagen Type I / Q000096:biosynthesis* / Q000235:genetics; D000090602:Collagen Type I, alpha 1 Chain; D004247:DNA / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology; D008957:Models, Genetic; D016328:NF-kappa B / Q000502:physiology; D010766:Phosphorylation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D051785:Smad Proteins / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D016328:NF-kappa B; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D003094:Collagen; D004247:DNA; D048031:JNK Mitogen-Activated Protein Kinases