title: Efficacy of oral erythromycin for treatment of feeding intolerance in preterm infants.
abstract: OBJECTIVE
  To determine the efficacy and safety of oral erythromycin (EM) for feeding intolerance in preterm infants < 35 weeks gestation.
  
  
  METHODS
  In this randomized, double-blinded, placebo-controlled trial, preterm infants with feeding intolerance were randomly allocated to a treatment group given EM ethyl succinate 10 mg/kg every 6 hours for 2 days, followed by 4 mg/kg every 6 hours for another 5 days, or to a control group given placebo. The primary outcome was time to full feeding (150 mL/kg/day) after the start of treatment.
  
  
  RESULTS
  Each group comprised 23 preterm infants, almost all of whom were < 32 weeks gestation. Baseline characteristics were similar between the 2 groups. Times to full feeding were significantly shorter and the number of withheld feeds were significantly less in the EM group than the control group; the respective medians (interquartile ranges) were 7 days (6 to 9 days) versus 13 days (9 to 15 days) (P < .001) and 1 episode (0 to 2 episodes) versus 9 episodes (2 to 13 episodes) (P < .001). No significant differences in episodes of sepsis, necrotizing enterocolitis, and cholestasis were observed.
  
  
  CONCLUSIONS
  Oral EM was effective and safe for treatment of feeding intolerance in preterm infants.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. tepnt@mahidol.ac.th
authors.forename: Pracha
authors.initials: P
authors.lastname: Nuntnarumit
authors.forename: Pakaphan
authors.initials: P
authors.lastname: Kiatchoosakun
authors.forename: Wacharee
authors.initials: W
authors.lastname: Tantiprapa
authors.forename: Suppawat
authors.initials: S
authors.lastname: Boonkasidecha
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000008:administration & dosage*; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000503:physiopathology; D005769:Gastrointestinal Motility; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology; D018529:Nutritional Support; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin