title: [Effect of gender and obesity on postprandial lipemia in non-diabetic normolipidemic subjects and subjects with familial combined hyperlipidemia].
abstract: BACKGROUND
  A new method based on self-measurement of diurnal capillary triglycerides (TG) facilitates the study of postprandial lipemia (PL). The objectives of our study are: to evaluate the effect of gender and obesity on PL measured by self-determination of diurnal capillary TG with Accutrend GCT in normolipidemic non-diabetic subjects and subjects with familial combined hyperlipidemia (FCH).
  
  
  METHODS
  We studied 23 FCH subjects (10 males) and 45 normolipidemic non-diabetic subjects (29 males). All subjects self-determine 3 diurnal capillary TG profiles during a week.
  
  
  RESULTS
  In normolipidemic non diabetic subjects significantly higher diurnal TG profiles and area under the curve of TG (AUCTGc) (25.25 +/-9.09 vs 19.71 +/- 6.16 mmolh/l) were found in males compared to females. In FCH subjects these differences were not found and the AUCTGc correlated with BMI (r = 0.510, p < 0.05) and waist circumference (r = 0.453, p < 0.05). Obese subjects (BMI >or= 27 kg/m2) showed diurnal TG profiles and AUCTGc significantly higher than the non-obese.
  
  
  CONCLUSIONS
  Normolipidemic non diabetic females showed a lower PL compared to males, probably due to the effect of estrogens in PL metabolism. Obesity negatively influences PL in normolipidemic non diabetic subjects and subjects with FCH.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, Departamento de Medicina, Universitat de Valencia, España.
authors.forename: A
authors.initials: A
authors.lastname: Bartual
authors.forename: C
authors.initials: C
authors.lastname: González
authors.forename: S
authors.initials: S
authors.lastname: Martínez Hervás
authors.forename: J T
authors.initials: JT
authors.lastname: Real
authors.forename: A B
authors.initials: AB
authors.lastname: García García
authors.forename: M
authors.initials: M
authors.lastname: Castro Cabezas
authors.forename: F J
authors.initials: FJ
authors.lastname: Chaves
authors.forename: M A
authors.initials: MA
authors.lastname: Priego
authors.forename: J F
authors.initials: JF
authors.lastname: Ascaso
authors.forename: R
authors.initials: R
authors.lastname: Carmena
mesh_terms: D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D019518:Postprandial Period; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase