Checkpoint activation: don't get mad too much.
The Mad2 protein is required to delay sister chromatid separation until all chromosomes have been aligned on the mitotic spindle. Two recent studies provide new insights into how Mad2 contributes to this remarkable task.
Lénárt
Péter
P
Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. lenart@imp.univie.ac.at
Peters
Jan-Michael
JM
D002135:Calcium-Binding Proteins / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002842:Chromatids / Q000378:metabolism; D018816:Genes, cdc; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D064246:Mad2 Proteins; D012097:Repressor Proteins / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism
D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D012097:Repressor Proteins