MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia.
OBJECTIVE
We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis.


METHODS
Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipumps were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer.


RESULTS
Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal.


CONCLUSIONS
Cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia.
Coates
Brian J
BJ
Department of Physiology, Midwestern University, Arizona College of Osteopathic Medicine, Glendale, AZ 85308, USA.
Broderick
Tom L
TL
Batia
Lyn M
LM
Standley
Cynthia A
CA
D000818:Animals; D002302:Cardiac Output; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D019331:NG-Nitroarginine Methyl Ester; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D018487:Ventricular Dysfunction, Left / Q000517:prevention & control*
D004791:Enzyme Inhibitors; D008278:Magnesium Sulfate; D019331:NG-Nitroarginine Methyl Ester