title: Effects of irradiation using a radioisotope-filled balloon on tissue hyperplasia caused by stent placement in a canine urethral model.
abstract: OBJECTIVE
  To evaluate 20 Gy and 40 Gy of intraluminal beta-irradiation using a 188Re-7mercaptoacetyltriglycine (MAG3)-filled balloon catheter to reduce tissue hyperplasia caused by covered stent placement for 12 weeks of follow-up in a canine urethral model.
  
  
  METHODS
  Ten dogs underwent 188Re-MAG3-filled balloon dilatation immediately after stent placement; 20 Gy at 1-mm tissue depth in group I (n = 5) and 40 Gy in group II (n = 5), whereas 5 dogs (group III) underwent conventional balloon dilatation only.
  
  
  RESULTS
  There were no significant differences among the three groups for percentage diameter of stenosis, although this was highest in group III. There was a tendency toward lower mean thickness of the epithelial layer and the papillary projection for out-stent area, and thickness of the papillary projection and degree of inflammatory cells for instent area in groups I and II compared with group III. Thickness of the papillary projection in out-stent area was significantly different among the three groups (P = 0.031). It was significantly less thick in group I than in group III (P < 0.05), whereas group II was not significantly different from group III.
  
  
  CONCLUSIONS
  188Re-MAG3-filled balloon dilatation has the potential to reduce tissue hyperplasia after 12 weeks of follow-up in a canine urethral model. The use of 20 Gy compared to 40 Gy did not show significant differences.
authors.affiliation: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Shin
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Song
authors.forename: Dae Hyuk
authors.initials: DH
authors.lastname: Moon
authors.forename: Seung-Jun
authors.initials: SJ
authors.lastname: Oh
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Tae-Hyung
authors.initials: TH
authors.lastname: Kim
authors.forename: Chul-Woong
authors.initials: CW
authors.lastname: Woo
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Park
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D002404:Catheterization / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006965:Hyperplasia / Q000209:etiology / Q000532:radiotherapy*; D009842:Oligopeptides / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome; D014521:Urethra / Q000473:pathology / Q000528:radiation effects; D014525:Urethral Stricture / Q000209:etiology / Q000532:radiotherapy*
chemical_list: D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C114893:rhenium-mercaptoacetyltriglycine