Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex.
We investigated the role of the ventromedial prefrontal cortex (vmPFC) in extinction of conditioned taste aversion (CTA) by microinfusing a protein synthesis inhibitor or N-methyl-d-asparate (NMDA) receptors antagonist into the vmPFC immediately following a non-reinforced extinction session. We found that the protein synthesis blocker anisomycin, but not the NMDA receptors antagonist D,L-2-amino-5-phosphonovaleric acid, impaired CTA extinction in the vmPFC. Anisomycin microinfusion into vmPFC had no effect on CTA acquisition and by itself did not induce CTA. These findings show the necessary role functional protein synthesis is playing in the vmPFC during the learning of CTA extinction.
Akirav
Irit
I
Department of Neurobiology and Ethology, The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel.
Khatsrinov
Vicktoria
V
Vouimba
Rose-Marie
RM
Merhav
Maayan
M
Ferreira
Guillaume
G
Rosenblum
Kobi
K
Maroun
Mouna
M
D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage / Q000494:pharmacology; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008845:Microinjections; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013649:Taste / Q000502:physiology
D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D000841:Anisomycin; D015763:2-Amino-5-phosphonovalerate