Microalbuminuria as a target to improve cardiovascular and renal outcomes.
Albuminuria is a cardiovascular and renal risk factor in patients with diabetes, patients with hypertension, and the general population. Risk has been shown to increase continuously with increasing urinary albumin levels, starting at levels that once were considered normal. This association is maintained even after adjusting for numerous other factors. Studies also established that a decrease in albuminuria leads to improvement in both cardiovascular and renal outcomes. These data suggest that urinary albumin should be measured routinely and treated to afford cardiovascular and renoprotection.
Basi
Seema
S
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.
Lewis
Julia B
JB
D000418:Albumins; D000419:Albuminuria / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D048909:Diabetes Complications / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control / Q000652:urine; D003920:Diabetes Mellitus / Q000503:physiopathology / Q000652:urine*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control* / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control* / Q000652:urine; D018450:Disease Progression; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000517:prevention & control / Q000652:urine; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
D000418:Albumins; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors