[Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese].
OBJECTIVE
To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.


METHODS
Polymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.


RESULTS
A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).


CONCLUSIONS
The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.
Yang
Guang
G
Department of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Deng
Ya-jun
YJ
Yan
Chun-xia
CX
Wu
Dong-ying
DY
Hu
Song-nian
SN
Zhu
Bo-feng
BF
Li
Sheng-bin
SB
Zhang
Xiu-qing
XQ
Liu
Yao
Y
D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013167:Spondylitis, Ankylosing / Q000235:genetics
D015796:HLA-B27 Antigen