title: Computational verification of anesthesia effect on temperature variations in rabbit eyes exposed to 2.45 GHz microwave energy.
abstract: This paper computationally verifies the effect of anesthesia on temperature variations in the rabbit eye due to microwave energy. The main reason for this investigation is that our previous paper suggested a reduction in blood flow due to the administration of anesthesia, resulting in an overestimated temperature increase. However, no quantitative investigation has yet been conducted. The finite-difference time-domain (FDTD) method is used for calculating power absorption and temperature variation in rabbits. For this purpose, we used a computational rabbit phantom, which is comprised of 12 tissues (including 6 eye tissues) with a resolution of 1 mm. Thermal constants of the rabbit were derived by comparing measured and calculated temperatures. For intense microwave exposure to the rabbit eye, time courses of calculated and measured temperatures were in good agreement for cases both with and without the administration of anesthesia. The point to be stressed is that under anesthesia the thermoregulatory response was inactivated and blood flow and basal metabolism was reduced.
authors.affiliation: Department of Computer Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan. ahirata@nitech.ac.jp
authors.forename: Akimasa
authors.initials: A
authors.lastname: Hirata
authors.forename: Soichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Masami
authors.initials: M
authors.lastname: Kojima
authors.forename: Ikuho
authors.initials: I
authors.lastname: Hata
authors.forename: Kanako
authors.initials: K
authors.lastname: Wake
authors.forename: Masao
authors.initials: M
authors.lastname: Taki
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujiwara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shiozawa
mesh_terms: D000042:Absorption / Q000528:radiation effects; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D001833:Body Temperature Regulation / Q000187:drug effects*; D005123:Eye / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D008954:Models, Biological; D011817:Rabbits; D013696:Temperature; D013821:Thermometers
chemical_list: D000777:Anesthetics