[Experiment study of tongfu huoxue decoction in the treatment of intracelebral hemorrhage].
OBJECTIVE
To investigate the effects of Tongfu Huoxue decoction on experimental intracelebral hemorrhage and the associated machenisms.


METHODS
The cerebral hemorrhage model in rats was induced by local injection of type VII collagenase and they were randomly divided into four groups. The treated groups were treated with Naoxuekang and Tongfu Huoxue decoction. The control groups were only treated with water. The changes of neurological defect were observed. The content of brain water, MDA, NO and the activity of SOD were measured.


RESULTS
The cerebral hemorrhage rats showed hemiplegia, and the hemorrhage brains showed celebral edema, higher quotient of brain and content of brain water, suggesting the hemorrhage model was established successfully. After the treatment of Tongfu Huoxue decoction, the hemorrhage rats showed smaller hemorrhage volume, the brain tissue from the hemorrhage rats had lower MDA content and the quotient of brain, and also had higher activity of SOD and content of NO.


CONCLUSIONS
Tongfu Huoxue decoction has treatment effects on cerebral hemorrhage.
Liu
Hua
H
The Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China.
Zhang
Guo-Ping
GP
Bie
Xiao-Dong
XD
Wan
Hai-Tong
HT
Fan
Shou-Yan
SY
Du
Yue-Guang
YG
D000818:Animals; D031170:Arctium / Q000737:chemistry; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017364:Collagenases; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045468:Fallopia japonica / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D027861:Prunus / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D017364:Collagenases