Membrane traffic: catching the lysosome express.
Recent work shows that specific adaptor interactions may sort receptors into distinct cohorts of clathrin-coated vesicles. These different vesicle populations deliver cargo to sorting endosomes of differing motilities and maturation rates, thereby determining the probability of receptor recycling and the duration of endosomal signaling.
Clague
Michael J
MJ
Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK. clague@liv.ac.uk
Hammond
Dean E
DE
D001692:Biological Transport; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
D011956:Receptors, Cell Surface