Antitumor effect of Pt(II) amine phosphonate complexes on sarcoma sa-180 in mice. Crystal structure of cis-dichlorobis(diethyl-4-pyridylmethylphosphonate-kappaN)platinum(II) hydrate, cis-[PtCl2(4-pmpe)2].H20.
The cisplatin analogoues platinum (II) complexes of the general formula cis-[PtL2Cl2], where L is monodentate diethyl 2-, 3- or 4-pyridylmethylphosphonate (2-, 3- or 4-pmpe) ligand, have been synthesized and characterized by means of IR and NMR (1H, 31P, 195Pt) spectroscopy. The crystal and molecular structure of cis-[Pt(4-pmpe)2 Cl2].H2O (A3) shows a square planar geometry of PtL2Cl2, with two organic molecules and two chloride leaving ligands in a cis configuration. The antitumor activity of the platinum (II) complexes was examined against Sarcoma Sa-180 in mice. The obtained results indicate a marked anticancer effect of platinum phosphonate complexes, and moderate nephrotoxicity evaluated in the BUN and creatinine levels in comparison with cisplatin (CDDP).
Aranowska
K
K
Department of Bioinorganic Chemistry, Medical University, Lódź, Poland.
Graczyk
J
J
Checińska
L
L
Pakulska
W
W
Ochock
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001806:Blood Urea Nitrogen; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D007674:Kidney Diseases / Q000139:chemically induced; D007928:Lethal Dose 50; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D008024:Ligands; D009944:Organoplatinum Compounds; C511288:cis-dichlorobis(diethyl-4-pyridylmethylphosphonate-kappaN)platinum(II) hydrate