title: FR220897 and FR220899, novel antifungal lipopeptides from Coleophoma empetri no. 14573.
abstract: Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573. This strain was identified as Coleophoma empetri No. 14573 from morphological and physiological characteristics. FR220897 and FR220899 showed antifungal activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis. Furthermore, FR220897 was effective in a murine model of systemic candidiasis.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kanasaki
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Motoo
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Katsuoka
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Seiji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hori
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D005285:Fermentation; D005658:Fungi / Q000145:classification* / Q000378:metabolism; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; C511075:FR 220897; C511076:FR 220899; D008074:Lipoproteins; D010456:Peptides, Cyclic