Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q.
BACKGROUND
Linkage studies have provided evidence for a prostate cancer susceptibility locus on chromosome 17q. The mitochondrial protein prohibitin (PHB) is a plausible candidate gene based on its chromosomal location (17q21) and known function.


METHODS
All coding regions and intron/exon junctions of the PHB gene were sequenced in 32 men from families participating in the University of Michigan Prostate Cancer Genetics Project that demonstrated evidence of linkage to 17q markers.


RESULTS
Although a number of nucleotide variants were identified, no coding region substitutions were identified in any of the 32 men with prostate cancer from 32 unrelated multiplex prostate cancer families.


CONCLUSIONS
PHB mutations do not appear to account for the linkage signal on 17q21-22 detected in PCGP families. Fine mapping of this region is in progress to refine the candidate region and highlight additional candidate prostate cancer susceptibility genes for sequence analysis.
White
K A
KA
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0946, USA.
Lange
E M
EM
Ray
A M
AM
Wojno
K J
KJ
Cooney
K A
KA
D000328:Adult; D000368:Aged; D002874:Chromosome Mapping / Q000379:methods; D002886:Chromosomes, Human, Pair 17; D005190:Family; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000091402:Prohibitins; D011467:Prostate / Q000378:metabolism; D019048:Prostatic Intraepithelial Neoplasia / Q000235:genetics* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics*
C000717328:PHB protein, human; D000091402:Prohibitins; D012097:Repressor Proteins