title: [Relationship between polymorphisms of vitamin D receptor gene and familial aggregation of HBsAg carriers].
abstract: OBJECTIVE
  To determine whether -Taq I T/C and -Fok I C/T polymorphisms of vitamin D receptor (VDR) gene are associated with the familial aggregation of hepatitis B virus (HBV) infection.
  
  
  METHODS
  Based on a population-based case-control family design, 288 family members from 27 case families and 230 family members from 27 control families were recruited. VDR gene polymorphisms were analyzed. VDR-Taq I T/C and VDR-Fok I C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The frequency of VDR-Taq I TT genotype in the case families was significantly higher than that in the control families (P < 0.05) , however, the frequency of VDR-Fok I CC genotype in the case families was significantly higher than that in the control families (P < 0.05). The frequency of family members carriying Taq I T-Fok I C haplotype in the case families was significantly higher than that in the control families (OR = 1.67, P < 0.05), however, the frequency of family members carrying Taq I C-Fok I T haplotype in the case families was significantly lower than that in the control families (OR = 0. 24, P < 0.05). The similar results were found in the familial biological kinship relatives with any HBV-infected makers.
  
  
  CONCLUSIONS
  VDR-Taq I and -Fok I gene polymorphisms are likely to play a substantial role in HBsAg familial aggregation.
authors.affiliation: Institute of Hepatitis Research, Affiliated You'an Hospital, Capital University of Medical Sciences, Beijing 100096, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shan
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Ji-rong
authors.initials: JR
authors.lastname: Gao
authors.forename: Yan-lei
authors.initials: YL
authors.lastname: Pang
authors.forename: Jun-hong
authors.initials: JH
authors.lastname: Li
authors.forename: Fu-min
authors.initials: FM
authors.lastname: Pang
authors.forename: Xin-hui
authors.initials: XH
authors.lastname: Guo
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Chi
authors.forename: Chang-geng
authors.initials: CG
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006509:Hepatitis B / Q000235:genetics*; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D006514:Hepatitis B Surface Antigens; D018167:Receptors, Calcitriol