Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera.
An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 microg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
Rojas
Rosario
R
Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia, Lima, Perú.
Caviedes
Luz
L
Aponte
José C
JC
Vaisberg
Abraham J
AJ
Lewis
Walter H
WH
Lamas
Gerardo
G
Sarasara
César
C
Gilman
Robert H
RH
Hammond
Gerald B
GB
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014709:Vero Cells
D000995:Antitubercular Agents; D014315:Triterpenes; C511675:aegicerin; C413246:oleanane; D009828:Oleanolic Acid