[Effect of streptozotocin-induced diabetes on the function of the central nervous system in rodents].
The prevalence of cognitive disorder, depression, and anxiety is about 2-fold higher in diabetic patients than in the general population. This higher prevalence is also observed in Japanese patients with diabetes. It has been reported that streptozotocin (STZ)-induced diabetic rodents demonstrate cognitive impairment, depressive-like behavior, and anxiety-like behavior. In addition, plasma corticosterone levels are significantly increased in STZ-induced diabetic rodents. Therefore, STZ-induced diabetic rodents demonstrate similar features as in patients with depression. In this review, we summarized the effect of STZ-induced diabetes on the function of the central nervous system in rodents and the similarity to the clinical features of several psychiatric disorders such as depression.
Miyata
Shigeo
S
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. miyata@hoshi.ac.jp
Saitoh
Akiyoshi
A
Hirano
Shoko
S
Kamei
Junzo
J
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D051379:Mice; D010913:Pituitary-Adrenal System / Q000503:physiopathology*