title: Prolongation of the luteal phase by prostaglandin E(2) during the estrous cycle in the cow. A preliminary report.
abstract: An experiment was conducted to determine the effects of prostaglandin E(2) (PGE(2)) on ovarian progesterone secretion during the estrous cycle in the cow. Intraluminal uterine catheters were implanted in three beef cows (2 treated, 1 control), and 1.3 mg of PGE(2) were infused into the uterus every 4 hours from days 9 through 21 post-estrus. Blood samples were collected from the jugular vein at 2-hour intervals from days 9 to 21 and twice daily from day 22 to 28 post-estrus. Progesterone was measured by applying a specific, direct plasma radioimmunoassay in all samples without extraction. Intrauterine infusion with PGE(2) resulted in maintenance of luteal-phase progesterone secretion until day 21 post-estrus, 4 days after luteal regression occurred in the vehicle-treated cow. In this study, we demonstrated that PGE(2) can prolong the presence of luteal phase plasma progesterone concentrations by possibly stimulating in vivo steroidogenesis by the corpus luteum during the estrous cycle in the cow.
authors.affiliation: Department of Animal Science Clemson University, Clemson, SC 29631 USA.
authors.forename: T
authors.initials: T
authors.lastname: Gimenez
authors.forename: D M
authors.initials: DM
authors.lastname: Henricks