A short review of some pharmacological, therapeutic and toxicological properties of praziquantel in man and animals.
Praziquantel is the current drug of choice against many trematodes and cestodes in both man and animals. This article summarizes the main pharmacological, therapeutic and toxicological properties of the drug, especially that have been reported during the last 10 years. In most cases, the effectiveness and safety of the drug have been confirmed, although there are currently concerns about the resistance/decreased effectiveness of the drug to certain Schistosome isolates, and also about the mutagenicity of the drug.
Ali
Badreldin H
BH
Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, P.O. Box 35, Al-Khod, Postal code 123, Sultanate of Oman. akthmali@squ.edu.om
D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004351:Drug Resistance; D006801:Humans; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D011223:Praziquantel / Q000493:pharmacokinetics / Q000633:toxicity*
D000871:Anthelmintics; D009153:Mutagens; D011223:Praziquantel