Shape deformation of the insula in schizophrenia.
Schizophrenia has been conceptualized to be a neurodevelopmental disorder. Neuroimaging evidence was generally findings of volumetric reductions in various brain structures. The shape analysis of the insula can uncover unique structural deformity in the neurodevelopmental disorder, which cannot be revealed from a simple volume measurement. The objective of this study was to demonstrate a subtle change of the insula in schizophrenia using our special shape analysis technique. Subjects were 23 patients with schizophrenia and 23 normal healthy subjects. A landmark-based structural and surface shape analysis of the insula was performed using high-spatial resolution magnetic resonance imaging. A characteristic finding was that the frontotemporal sides of the right insula were deformed in the patients with schizophrenia compared with normal controls. This deformation can be associated with abnormal development of the frontal and temporal lobes in schizophrenia.
Jang
Dong-Pyo
DP
Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
Kim
Jae-Jin
JJ
Chung
Tae-Sub
TS
An
Suk Kyoon
SK
Jung
Young Chul
YC
Lee
Jun-Kee
JK
Lee
Jong-Min
JM
Kim
In-Young
IY
Kim
Sun I
SI
D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology; D012016:Reference Values; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology