Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion.
Lupeol and betulinic acid inhibit the proliferation of Plasmodium falciparum parasites by inhibition of the invasion of merozoites into erythrocytes. This conclusion is based on experiments employing parasite cultures synchronized by magnetic cell sorting (MACS). Identical inhibitory effects were observed upon incubation of synchronous parasite cultures in the presence of the triterpenoids, and when the parasite cultures were grown in a triterpenoid-free medium with erythrocytes preloaded with the triterpenoids.
Ziegler
Hanne L
HL
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.
Staalsø
Trine
T
Jaroszewski
Jerzy W
JW
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006801:Humans; D053978:Pentacyclic Triterpenes; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000502:physiology; D014315:Triterpenes / Q000494:pharmacology*; D000094062:Betulinic Acid; D000094042:Lupanes
D000962:Antimalarials; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid; C010480:lupeol; D000094042:Lupanes