title: Linkage but not association of calpain-10 to type 2 diabetes replicated in northern Sweden.
abstract: We present data from a genome-wide scan identifying genetic factors conferring susceptibility to type 2 diabetes. The linkage analysis was based on 59 families from northern Sweden, consisting of a total of 129 cases of type 2 diabetes and 19 individuals with impaired glucose tolerance. Model-free linkage analysis revealed a maximum multipoint logarithm of odds score of 3.19 for D2S2987 at 267.7 cM (P=0.00058), suggesting that a gene conferring susceptibility to type 2 diabetes in the northern Swedish population resides in the 2q37 region. These data replicate, in a European population, previously identified linkage of marker loci in this region to type 2 diabetes in Mexican Americans. In contrast, no evidence in support of association to the previously identified single nucleotide polymorphisms in the calpain-10 gene was observed in a case-control cohort derived from the same population.
authors.affiliation: Department of Medical Biosciences, Division of Medical and Clinical Genetics, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Einarsdottir
authors.forename: Sofia
authors.initials: S
authors.lastname: Mayans
authors.forename: Karin
authors.initials: K
authors.lastname: Ruikka
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Escher
authors.forename: Petter
authors.initials: P
authors.lastname: Lindgren
authors.forename: Asa
authors.initials: A
authors.lastname: Agren
authors.forename: Mats
authors.initials: M
authors.lastname: Eliasson
authors.forename: Dan
authors.initials: D
authors.lastname: Holmberg
mesh_terms: D000328:Adult; D000483:Alleles; D002154:Calpain / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D016015:Logistic Models; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013548:Sweden; D044465:White People / Q000235:genetics*
chemical_list: D002154:Calpain; C415197:calpain 10