[Collagens associated with basement membranes and their matricryptins].
The superfamily of collagens is comprised of 27 members (reviewed by Myllyharju & Kivirikko, 2004; Ricard-Blum & Ruggiero, 2005; Ricard-Blum et al., 2005), which are classified into several subgroups according to their structural features and supramolecular assemblies. Fibrillar collagens and FACITS (Fibril-Associated Collagens with Interrupted Triple helix) are described in the paper by Ruggiero et al. in this issue. Our paper reports recent advances on collagens associated to basement membranes. It focuses on the multiplexin family (including collagens XV and XVIII) and on membrane collagens present in skin, namely collagens XIII and XVII. The mechanisms leading to the shedding of their ectodomain from cell membrane and the biological roles of their shedded domains are discussed. The last part of the paper is devoted to several fragments of basement membrane collagens, called matricryptins or matrikins, and to their biological activities.
Ricard-Blum
Sylvie
S
Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-UCBL, IFR 128 Biosciences Lyon-Gerland, 7, passage du Vercors, 69367 Lyon Cedex 07. s.ricard-blum@ibcp.fr
Faye
Clément
C
D000818:Animals; D001485:Basement Membrane / Q000737:chemistry* / Q000648:ultrastructure; D003094:Collagen / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D043169:Endostatins / Q000502:physiology; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010446:Peptide Fragments / Q000737:chemistry / Q000502:physiology; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D012995:Solubility; D013329:Structure-Activity Relationship; D009626:Terminology as Topic
D043169:Endostatins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D020033:Protein Isoforms; D003094:Collagen