Engineering emissive europium and terbium complexes for molecular imaging and sensing.
Emissive f-block coordination complexes constitute an important class of optical probes, with applications ranging from sensing of bioactive species, high throughput assays and screening protocols in vitro, to time-resolved imaging studies in cellulo or in vivo. The key chemistry issues to be addressed in complex design and characterisation are defined, with an emphasis on the use of emissive europium and terbium complexes and their conjugates in molecular imaging. Both luminescent 'tags' useful in energy transfer studies and 'responsive' systems for sensing are discussed.
Pandya
Shashi
S
Department of Chemistry, Durham University, South Road, Durham, UKDH1 3LE.
Yu
Junhua
J
Parker
David
D
D002621:Chemistry / Q000379:methods; D005063:Europium / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D046911:Macromolecular Substances / Q000737:chemistry*; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D008956:Models, Chemical; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D013725:Terbium / Q000737:chemistry*
D005456:Fluorescent Dyes; D046911:Macromolecular Substances; D015335:Molecular Probes; D013725:Terbium; D005063:Europium