title: Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 cases.
abstract: While hypersexuality and paraphilia are known side effects of anti-Parkinson medications, it is seldom reported. Furthermore, selegiline is rarely implicated in such behaviors. We report two cases of early onset PD who experienced paraphilia and hypersexuality when selegiline was initiated, and later developing obsessive-compulsive and punding behavior with the addition of dopamine agonists. Social repercussions may prohibit patients and/or their families from volunteering such information.
authors.affiliation: Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine, P.O. Box 100236, Gainesville, FL 32610, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Shapiro
authors.forename: Yu Ling
authors.initials: YL
authors.lastname: Chang
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Munson
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Fernandez
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003192:Compulsive Behavior / Q000139:chemically induced / Q000523:psychology; D004882:Erotica; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D010554:Personality Disorders / Q000139:chemically induced / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012642:Selegiline / Q000009:adverse effects* / Q000627:therapeutic use; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000523:psychology
chemical_list: D000978:Antiparkinson Agents; D012642:Selegiline