title: [Influence of age on optical aberrations of the human eye].
abstract: BACKGROUND
  Currently the influence of age on corneal and ocular aberrations is still insufficiently known. The aim of this clinical study was to compare age-related aberrations of human eyes.
  
  
  METHODS
  In a prospective study 98 eyes of 49 healthy patients ranging from 17 to 65 years of age (38.6+/-10.0 years) were consecutively examined. The best corrected visual acuity ranged from 0.8 to 1.6; 48 eyes were emmetropic (SE+/-0.5 D), 42 eyes myopic (SE <-0.5 to -6.75 D), and 8 eyes hyperopic (SE >+0.5 to +3.88 D). The corneal aberrations were derived from corneal topography (Keratron Scout, Optikon). The measurement of ocular aberrations was performed with a Tscherning wavefront aberrometer (ORK, Schwind). The aberrations of the Zernike coefficients and RMS values (1st to 4th order) were determined.
  
  
  RESULTS
  The mean corneal and ocular Zernike coefficients of higher order were smaller than 0.2 microm. There was an evident decrease of wavefront aberrations with increasing order. Higher order corneal aberrations were larger than the corresponding ocular aberrations. With increasing age higher optical errors increased in complexity, and the correlation of corneal and ocular aberrations decreased with significant differences. Although the corneal ocular RMS value of the 3rd and 4th order correlated in the younger group (r=0.51, p=0.0001), there was no correlation in the older group (r=-0.48, p=0.832). The influence of age caused a significant increase of ocular aberrations of the 3rd and 4th order, in particular a tenfold extension of coma (C07) (p=0.002), a twofold extension of spherical aberration (C12) (p=0.0001), and an increase of the 3rd and 4th order RMS values (p=0.001).
  
  
  CONCLUSIONS
  Increased age induced an increase in optical aberrations of the eye, which demonstrates the influence of the lens on ocular aberrations. The combination of corneal and ocular diagnostic methods is recommendable for a better understanding of visual performance.
authors.affiliation: Klinik für Augenheilkunde, Vivantes Klinikum Neukölln, Rudower Strasse 48, 12358 Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Jahnke
authors.forename: C
authors.initials: C
authors.lastname: Wirbelauer
authors.forename: D T
authors.initials: DT
authors.lastname: Pham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*