title: [Immunity and neurodegeneration: new concepts in multiple sclerosis].
abstract: Multiple sclerosis is an autoimmune demyelinating disease of the central nervous system that leads to a progressive deterioration of the neurological functions. The concept of primary myelin and oligodendrocyte damage with axon sparing (axon-myelin dissociation) has been recently reconsidered with the demonstration that neuro-axonal lesions are an early phenomenon, linked to the inflammatory process, observed outside demyelinated areas, and correlated with the progression of the disease. Neurodegeneration in MS, long considered as a late process following recurrent episodes of demyelination, is now accepted as an early and major trigger of MS pathogenesis on which research should focus in the
authors.affiliation: Service de neurologie, Unité de neuroimmunologie, HUG, Genève. patrice.lalive@hcuge.ch
authors.forename: P H
authors.initials: PH
authors.lastname: Lalive
authors.forename: M
authors.initials: M
authors.lastname: Schluep
authors.forename: M
authors.initials: M
authors.lastname: Chofflon
authors.forename: R
authors.initials: R
authors.lastname: Du Pasquier
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000473:pathology