Epoetin-induced pure red cell aplasia successfully treated with androgens.
Pure red cell aplasia (PRCA) is a severe, non-regenerative form of anaemia, with selective erythroid aplasia of the bone marrow. It appears as a severe complication of treatment for anaemia of end-stage renal insufficiency with erythropoiesis-stimulating agents. There is no definite treatment. We described for the first time a patient with chronic renal failure and antibody-mediated PRCA successfully treated with androgens.
Sánchez de la Nieta
Maria Dolores
MD
Nephrology Unit, Alarcos Hospital, Ciudad Real, Spain.
Caparrós
Guadalupe
G
Rivera
Francisco
F
D000368:Aged; D000728:Androgens / Q000008:administration & dosage*; D000740:Anemia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D011994:Recombinant Proteins; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*
D000728:Androgens; D011994:Recombinant Proteins; D004921:Erythropoietin; D009277:Nandrolone; D000077603:Nandrolone Decanoate