Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3.
Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by [1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and -3 inhibitors with potencies as low as 20 microM.
Giguère
Denis
D
Department of Chemistry, Université du Québec à Montréal, P.O. Box 8888, Succ. Centre-Ville Montreal, Que., Canada H3C 3P8.
Patnam
Ramesh
R
Bellefleur
Marc-André
MA
St-Pierre
Christian
C
Sato
Sachiko
S
Roy
René
R
D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology; D037483:Galectin 1 / Q000037:antagonists & inhibitors*; D037502:Galectin 3 / Q000037:antagonists & inhibitors*; D006384:Hemagglutination / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D002241:Carbohydrates; D037483:Galectin 1; D037502:Galectin 3; D007555:Isoxazoles; D014230:Triazoles