[Studies of immunomodulation caused by selenium-enriched phycocyanin].
An influense was studied in rats of selenium enriched phycocyanin (Se-PC) from food microalgae Spirulina on anaphylactic reaction severity and circulating antibody response against model allergen--hen's egg white ovalbumin. Se-PC was introduced into diet in form of protein isolate precipitated with ammonia sulphate. Se-PC dosage made up to 450 mcg per rat daily that corresponded to 5 mcg of selenium. There were no differences revealed between experimental and control group that received standard diet in severity of anaphylactic reaction. Nevertheless rats receiving Se-PC demonstrated significantly increased specific IgG response. The probable immunomodulating properties of Se-PC included into food are discussed.
Egorova
E A
EA
Gmoshinskiĭ
I V
IV
Zorin
S N
SN
Mazo
V K
VK
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D019587:Dietary Supplements; D015387:Egg Proteins, Dietary / Q000276:immunology*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D010798:Phycocyanin; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds
D015387:Egg Proteins, Dietary; D007155:Immunologic Factors; D018036:Selenium Compounds; D010798:Phycocyanin; D010047:Ovalbumin