Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications.
The present study describes 31 clinical cases of neuroendocrine cervical carcinoma (NECC) treated at Mackay Memorial Hospital between January 1, 1991 and October 31, 2003. There are two cases of atypical carcinoid tumor (ACT), four cases of large-cell neuroendocrine carcinoma (LCNEC), and 25 cases of small-cell neuroendocrine carcinoma (SCNEC). Overall survival did not differ significantly in relation to surgery, tumor histology, age, FIGO stages, chemotherapeutic regimens or lymph node involvement. The specimens available did not permit HPV (human papillomavirus)-DNA analysis in 5 cases (5/31, 9.7%). The HPV viral infection was absent in 8 cases (8/31, 26%); 17 cases of HPV-18 (17/31); and 1 case of HPV-16 (1/31). The prognosis between mixed and pure type histologic patterns is not significant. The mean survival time for all patients was 32.3 months. The 2-year and 5-year survival rates were 54.8% and 31.5% for all patients. The results of this study reaffirm the biologically aggressive nature of this rare malignancy, its low survival rate, and its very unpredictable prognostic factors. Effective treatments of neuroendocrine cervical tumor still remain inconclusive. Further efforts are still required to identify prognostic factors for this uncommon disease.
Wang
Kung-Liahng
KL
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taiwan, ROC. kl421229@ms6.hinet.net
Yang
Yuh-Cheng
YC
Wang
Tao-Yeuan
TY
Chen
Jen-Ruei
JR
Chen
Tze-Chien
TC
Chen
Horng-Shen
HS
Su
Tsung-Hsien
TH
Wang
Kuo-Gon
KG
D000328:Adult; D002276:Carcinoid Tumor / Q000473:pathology / Q000821:virology; D018287:Carcinoma, Large Cell / Q000473:pathology / Q000821:virology; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000821:virology; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D015344:DNA Probes, HPV; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000378:metabolism; D052161:Human papillomavirus 18 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology
D015344:DNA Probes, HPV