Cytotoxic chalcones and flavanones from the tree bark of Cryptocarya costata.
A new flavanone, 7-hydroxy-5,6-dimethoxyflavanone (1), together with three other flavonoids, didymocarpin (2), 2',4'-dihydroxy-5',6'-dimethoxychalcone (3), and isodidymocarpin (4), had been isolated from the methanol extract of the tree bark of Cryptocarya costata. The structures of these compounds were determined based on spectral evidence, including UV, IR, 1-D and 2-D NMR, and mass spectra. Cytotoxic properties of compounds 1-4 were evaluated against murine leukemia P-388 cells. The chalcones 3 and 4 were found to have substantial cytotoxicity with IC50 of 5.7 and 11.1 microM, respectively.
Usman
Hanapi
H
Chemistry Department, Hasanuddin University, Jalan Perintis Kemerdekaan, Makassar, Indonesia.
Hakim
Euis H
EH
Harlim
Tjodi
T
Jalaluddin
Muhammad N
MN
Syah
Yana M
YM
Achmad
Sjamsul A
SA
Takayama
Hiromitsu
H
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D031369:Cryptocarya / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D018547:Plant Stems / Q000737:chemistry*; D014197:Trees / Q000737:chemistry*
D047188:Chalcones; D044950:Flavanones