Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity.
The ligands (Bpy-H, 5) have been designed to connect the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It has been revealed that the new Hoechst ligand long Bpy-H (5L) having a long linker exhibits Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a selective manner depending on the length of the linker of the ligand as well as on the distance between the two A(3)T(3) sites of DNA. [reaction: see text]
Tanada
Mikimasa
M
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Tsujita
Saori
S
Kataoka
Tomonobu
T
Sasaki
Shigeki
S
D001562:Benzimidazoles / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D012689:Sequence Homology, Nucleic Acid
D001562:Benzimidazoles; D008024:Ligands; C447680:hoechst 32258; D003300:Copper; D004247:DNA