title: Discovery of potent CRTh2 (DP2) receptor antagonists.
abstract: Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, UK. tim.birkinshaw@astrazeneca.com
authors.forename: Timothy N
authors.initials: TN
authors.lastname: Birkinshaw
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Teague
authors.forename: Claire
authors.initials: C
authors.lastname: Beech
authors.forename: Roger V
authors.initials: RV
authors.lastname: Bonnert
authors.forename: Stephen
authors.initials: S
authors.lastname: Hill
authors.forename: Anil
authors.initials: A
authors.lastname: Patel
authors.forename: Sara
authors.initials: S
authors.lastname: Reakes
authors.forename: Hitesh
authors.initials: H
authors.lastname: Sanganee
authors.forename: Iain G
authors.initials: IG
authors.lastname: Dougall
authors.forename: Tim T
authors.initials: TT
authors.lastname: Phillips
authors.forename: Sylvia
authors.initials: S
authors.lastname: Salter
authors.forename: Jerzy
authors.initials: J
authors.lastname: Schmidt
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Arrowsmith
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrillo
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Bell
authors.forename: Stuart W
authors.initials: SW
authors.lastname: Paine
authors.forename: Richard
authors.initials: R
authors.lastname: Weaver
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012220:Rhinitis / Q000188:drug therapy*
chemical_list: D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D007213:Indomethacin; C036293:prostaglandin D2 receptor