title: What is the outcome of targeted tuberculosis screening based on universal genotyping and location?
abstract: OBJECTIVE
  Identifying and treating persons with latent tuberculosis (TB) infection (LTBI) at high risk for developing TB is part of the current TB elimination strategy. There are no specific criteria, other than medical risks, to designate groups as high risk for developing TB. We hypothesized that, if location-based screenings were done in communities where persons with genotypically clustered Mycobacterium tuberculosis resided, then persons with LTBI from recent transmission and with undiagnosed TB could be identified.
  
  
  METHODS
  Location-based TB screenings were done in partnership with multiple community-based organizations using resources previously used for other types of screening.
  
  
  RESULTS
  Location-based screenings identified one person with TB for every 83 screened, and one person with LTBI for every five screened. The yield of this targeted screening program for discovering persons with TB and LTBI exceeded what would be expected from nontargeted screening in a county with a TB incidence of 5.7 per 100,000 population.
  
  
  CONCLUSIONS
  Genotyping combined with geographic information systems analysis can potentially be used to define high-risk status and to define areas for location-based TB screenings.
authors.affiliation: School of Medicine, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.
authors.forename: Patrick K
authors.initials: PK
authors.lastname: Moonan
authors.forename: Joseph
authors.initials: J
authors.lastname: Oppong
authors.forename: Behzad
authors.initials: B
authors.lastname: Sahbazian
authors.forename: Karan P
authors.initials: KP
authors.lastname: Singh
authors.forename: Raghbir
authors.initials: R
authors.lastname: Sandhu
authors.forename: Gerry
authors.initials: G
authors.lastname: Drewyer
authors.forename: Terry
authors.initials: T
authors.lastname: Lafon
authors.forename: Marco
authors.initials: M
authors.lastname: Marruffo
authors.forename: Teresa N
authors.initials: TN
authors.lastname: Quitugua
authors.forename: Charles
authors.initials: C
authors.lastname: Wallace
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Weis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000175:diagnosis* / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D040362:Geographic Information Systems; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D013781:Texas; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology