title: Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection.
abstract: A liquid chromatographic (LC) method for determining 14 sulfonamide (SA) (sulfanilamide, sulfadiazine (SDZ), sulfathiazole, sulfapyridine, sulfamerazine (SMR), sulfamethazine (SMZ), sulfamethizole, sulfamethoxypyridazine, sulfachloropyridazine (SCP), sulfamonomethoxine, sulfadoxine, sulfamethoxazole, sulfadimethoxine (SDM), and sulfaquinoxaline (SQX)) residues in edible catfish, shrimp and salmon tissues was developed and validated at 5, 10 or 20 ng g(-1). The method was then used to determine residues in tissues of catfish, shrimp and salmon dosed with six selected sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine, sulfachloropyridazine, sulfadimethoxine and sulfaquinoxaline). All assays were within U.S. Food and Drug Administration guidelines for recovery and intra-assay variability. The method was developed to determine possible sulfonamide residues in aquacultured catfish, shrimp and salmon produced for food.
authors.affiliation: Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Tgehring@nctr.fda.gov
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Gehring
authors.forename: Bill
authors.initials: B
authors.lastname: Griffin
authors.forename: Rod
authors.initials: R
authors.lastname: Williams
authors.forename: Charles
authors.initials: C
authors.lastname: Geiseker
authors.forename: Larry G
authors.initials: LG
authors.lastname: Rushing
authors.forename: Paul H
authors.initials: PH
authors.lastname: Siitonen
mesh_terms: D000818:Animals; D002397:Catfishes; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003445:Crustacea; D004350:Drug Residues / Q000032:analysis*; D005396:Fish Products / Q000032:analysis*; D015203:Reproducibility of Results; D012474:Salmon; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013449:Sulfonamides / Q000032:analysis*
chemical_list: D013449:Sulfonamides