title: Current concepts of cell-cycle regulation and its relationship to oocyte maturation, fertilization and embryo development.
abstract: Genetic and biochemical approaches have contributed to an explosion of literature on cell-cycle control. Regulation of the cell-cycle is controlled by a series of kinases and phosphatases. Key control points are during the G(1)-S and G(2)-M transitions. During both transitions, cyclins interact with a specific kinase to allow a cell to pass through that phase. The meiotic maturation of oocytes, fertilization and embryo development are all events influenced by cell-cycle regulation. Understanding cell-cycle control should provide new ways for gamete and embryo biologists to approach culture and development problems.
authors.affiliation: Department of Meat and Animal Science, University of Wisconsin-Madison Madison, WI 53706, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Parrish
authors.forename: C I
authors.initials: CI
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Bae