title: PAMAM dendrimers for efficient siRNA delivery and potent gene silencing.
abstract: Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
authors.forename: Jiehua
authors.initials: J
authors.lastname: Zhou
authors.forename: Jiangyu
authors.initials: J
authors.lastname: Wu
authors.forename: Nadia
authors.initials: N
authors.lastname: Hafdi
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Behr
authors.forename: Patrick
authors.initials: P
authors.lastname: Erbacher
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D020868:Gene Silencing; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D034741:RNA, Small Interfering