Childhood empyema: limited potential impact of 7-valent pneumococcal conjugate vaccine.
During 2003-2004, locally presenting pleural empyema cases in children increased 3-fold. Antigen analysis of empyema fluid identified Streptococcus pneumoniae in 27 of 29 cases for whom samples were available and capsular polysaccharide type 1 in 18 of these. Use of a conjugate vaccine without serotype 1 antigen would have had limited impact on this morbidity in our region.
Fletcher
Margaret
M
Faculty of Health and Social Care, University of the West of England, Bristol, UK. Margaret.Fletcher@uwe.ac.uk
Leeming
John
J
Cartwright
Keith
K
Finn
Adam
A
D017677:Age Distribution; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D016724:Empyema, Pleural / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007109:Immunity / Q000502:physiology; D015994:Incidence; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D006113:United Kingdom / Q000453:epidemiology; D018074:Vaccines, Conjugate / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate