title: A "true" polymicrobial endocarditis: Candida tropicalis and Staphylococcus aureus--to a drug user. Case presentation and literature review.
abstract: Polymicrobial endocarditis is more frequent in intravenous drug user (IVDU). Combined therapy--medical and surgical--represents the standard of care, but long-term suppressive therapy duration in fungal endocarditis is still debated. The polymicrobial endocarditis is rare: 1-3%. It is being observed with increasing frequency among drug users; a predominance of tricuspid valve involvement exists. We report a case of dual etiology infective endocarditis (IE) - Candida tropicalis and Staphylococcus aureus - in a IVDU; the treatment was combined, medical and surgical, and was followed by a suppressive antifungal therapy. We review the other published Candida tropicalis endocarditis cases and discuss their optimal management.
authors.affiliation: Matei Balş Institute of Infectious Diseases, Bucharest, Romania. gabrielp@yahoo.com
authors.forename: G A
authors.initials: GA
authors.lastname: Popescu
authors.forename: T
authors.initials: T
authors.lastname: Prazuck
authors.forename: D
authors.initials: D
authors.lastname: Poisson
authors.forename: Cristina
authors.initials: C
authors.lastname: Picu
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D041022:Candida tropicalis / Q000187:drug effects / Q000472:pathogenicity; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity; D019966:Substance-Related Disorders
chemical_list: D000890:Anti-Infective Agents