Diacylglycerol, phosphatidic acid, and the converting enzyme, diacylglycerol kinase, in the nucleus.
There exists phosphoinositide (PI) cycle in the nucleus, which is operated differentially from the classical PI cycle at the plasma membrane. Evidence has been accumulated that nuclear PIs and the related enzymes are closely involved in a variety of nuclear processes, although the details remain to be elucidated. In this mini review, some components of PI cycle, i.e., diacylglycerol, phosphatidic acid, and the converting enzyme, diacylglycerol kinase, in the nucleus are discussed with focusing on the lipid metabolism, cell cycle regulation, and animal models.
Goto
Kaoru
K
Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan. kgoto@med.id.yamagata-u.ac.jp
Hozumi
Yasukazu
Y
Kondo
Hisatake
H
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism*; D019852:Diacylglycerol Kinase / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism*; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D009685:Nuclear Envelope / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D004075:Diglycerides; D008051:Lipid Bilayers; D010712:Phosphatidic Acids; D019852:Diacylglycerol Kinase