Does instant coffee prevent acute liver injury induced by carbon tetrachloride (CCl(4))?
OBJECTIVE
To investigate the protective effect of instant coffee (IC) on acute liver injury induced by CCl(4).


METHODS
The study included 32 rats which were allocated to four groups: control (n: 8), CCl(4) (n: 8), CCl(4)+IC (n: 8) and IC (n: 8). Malondialdehyde, which is a lipid peroxidation product, and levels of antioxidant capacity were measured and histopathological data were compared.


RESULTS
It was seen in the study that lipid peroxidation products that increased in the plasma and liver tissue of the CCl(4) group decreased by IC administration. There was an increase in the measured antioxidant parameters, which were total antioxidant capacity (TAOC), sulphydryl (SH) and ceruloplasmin levels. Histopathologically, it was found that inflammation and necrosis which increased in the group administered CCl(4) decreased significantly with IC administration, but there steatosis did not change.


CONCLUSIONS
It was seen that IC had a protective role in acute liver injury induced by CCl(4), but did not affect steatosis.
Ozercan
Ibrahim Hanifi
IH
Fırat University, Faculty of Medicine, Department of Pathology, 23119 Elazig, Turkey.
Dagli
Adile Ferda
AF
Ustundag
Bilal
B
Ozercan
Mehmet Resat
MR
Bahcecioglu
Ibrahim Halil
IH
Celik
Hakim
H
Yalniz
Mehmet
M
Poyrazoglu
Orhan Kursat
OK
Ataseven
Huseyin
H