The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial.
The study compared the effect of a sustained silver-release foam dressing (Contreet Foam) with a foam dressing (Allevyn Hydrocellular) without added silver in critically colonised venous leg ulcers with delayed healing. The study was a multicentre, open, randomised, controlled study lasting for 4 weeks. Ulcer area and healing were assessed weekly. Odour, maceration, absorption capacity and leakage were evaluated at dressing changes. All adverse events were recorded. One hundred and twenty-nine patients were included (Contreet Foam: 65, Allevyn Hydrocellular: 64). The two groups were comparable in all respects. After 4 weeks, there was a significantly greater reduction in ulcer area in the Contreet Foam group (45%) than in the Allevyn Hydrocellular group (25%). After 1 and 4 weeks, odour was present in significantly less of the ulcers in the Contreet Foam group (17% and 19%, respectively) compared with the Allevyn Hydrocellular group (47% and 39%, respectively) and at the final visit there were significantly fewer leakages in the Contreet Foam group (19%) compared with the Allevyn Hydrocellular group (49%). Also, less maceration was observed after 1 and 4 weeks in the Contreet Foam group (34% and 37%, respectively) compared with the Allevyn Hydrocellular group (55% and 48%, respectively). The occurrence and cause of adverse events were equally distributed between the study groups. The present study provides evidence of the superior performance of the silver-releasing dressing, Contreet Foam, compared with a traditional moist foam wound healing dressing in the treatment of critically colonised, chronic venous leg ulcers. The results of this randomised, controlled study suggest an important role of sustained silver-releasing dressings in the treatment of critically colonised chronic wounds.
Jørgensen
Bo
B
Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark.
Price
Patricia
P
Andersen
Klaus E
KE
Gottrup
Finn
F
Bech-Thomsen
Niels
N
Scanlon
Elizabeth
E
Kirsner
Robert
R
Rheinen
Henriette
H
Roed-Petersen
Jytte
J
Romanelli
Marco
M
Jemec
Gregor
G
Leaper
David J
DJ
Neumann
Martino Ha
MH
Veraart
Joep
J
Coerper
Stefan
S
Agerslev
Rikke H
RH
Bendz
Susanne H
SH
Larsen
Jan R
JR
Sibbald
R Gary
RG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D047070:Bandages, Hydrocolloid; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011140:Polyurethanes; D011788:Quality of Life; D018030:Silver Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000628:therapy*
D003692:Delayed-Action Preparations; D011140:Polyurethanes; D018030:Silver Compounds; C081143:allevyn