title: ['Migraine and a hole in the heart': causal relationship between migraine and patent foramen ovale not established].
abstract: The relationship between patent foramen ovale (PFO) and migraine is controversial. A common genetic background seems possible, but there is no evidence for a causal relationship. Despite the lack of evidence, PFO closure is recommended in many countries as a remedy for migraine. At present, PFO closure for migraine should only be carried out under strictly controlled clinical trial conditions.
authors.affiliation: Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden.
authors.forename: G M
authors.initials: GM
authors.lastname: Terwindt
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: J J
authors.initials: JJ
authors.lastname: Bax
authors.forename: S F T M
authors.initials: SF
authors.lastname: de Bruijn
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
mesh_terms: D020022:Genetic Predisposition to Disease; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000601:surgery; D006801:Humans; D008881:Migraine Disorders / Q000209:etiology* / Q000601:surgery; D012307:Risk Factors