title: Preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer.
abstract: The purpose of the present study was to evaluate preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer (EOC). Preoperative serum CA125 levels from 118 women with FIGO (International Federation of Gynaecology and Obstetrics) stage I EOC were analysed and the prognostic value was evaluated and compared with other prognostic factors (age, grade, substages, histologic type). By the Kaplan-Meier estimate we demonstrated that patients with stage I EOC and preoperative serum CA125 levels <65 U/mL had a significantly longer survival compared to stage I EOC patients with preoperative serum CA125 > or = 65 U/mL (p=0.01). The results from the present study may be useful for decision making respecting postoperative chemotherapy in stage I EOC patients. Serum CA125 levels might therefore be included as a prognostic factor in future clinical trials of stage I EOC.
authors.affiliation: Department of Gynaecology and Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. alpetri@dadlnet.dk
authors.forename: Anette Lykke
authors.initials: AL
authors.lastname: Petri
authors.forename: Estrid
authors.initials: E
authors.lastname: Høgdall
authors.forename: Ib Jarle
authors.initials: IJ
authors.lastname: Christensen
authors.forename: Susanne Krüger
authors.initials: SK
authors.lastname: Kjaer
authors.forename: Jan
authors.initials: J
authors.lastname: Blaakaer
authors.forename: Claus Kim
authors.initials: CK
authors.lastname: Høgdall
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D003718:Denmark; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008137:Longitudinal Studies; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; C549756:NBR1 protein, human; D011506:Proteins