Effects of Hydrocotyle sibthorpioides extract on transplanted tumors and immune function in mice.
This paper describes the effects of an ethanolic extract of Hydrocotyle sibthorpioides on transplanted tumors and immunologic function in mice. When the H. sibthorpioides extract was administered orally at a dose of 1.5 or 3.0 g/kg body wt./day for 10 days, the inhibition rates for murine hepatic carcinoma clone (Hep), sarcoma 180 crocker clone (S(180)), and uterine cervical carcinoma clone (U(14)) were significantly enhanced. The antitumor activity of H. sibthorpioides is comparable to that of the common antitumor agent 5-fluorouracil. Also, our results indicate that the H. sibthorpioides extract promoted the thymus and spleen indices, and humoral immunity of mice. These observations demonstrated that H. sibthorpioides exerted a potent inhibitory effect on the growth of tumors, in addition to mediating immunomodulatory effects in mice.
Yu
Farong
F
Gansu Institute of Political Science and Law, Lanzhou 730070, China. fyu@ufl.edu
Yu
Fahong
F
McGuire
P M
PM
Li
R
R
Wang
R
R
D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D028041:Centella; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D007155:Immunologic Factors; D010936:Plant Extracts