Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain.
The continuous intra-cortical infusion of a glia toxin, fluorocitrate, at the concentration of 1 mM caused a decrease in the cortical extracellular contents of an intrinsic coagonist for the N-methyl-D-aspartate (NMDA) type glutamate receptor, D-serine, by peaking at 40 min by -25% but produced an increase in those of glycine and L-serine. The attenuated glial activity by fluorocitrate was verified by a marked reduction in the extracellular glutamine contents. The present findings suggest that a group of glial cells such as a population of the protoplasmic astrocytes could, at least in part, participate differently in the regulation of the extracellular release of D-serine and another NMDA coagonist glycine in the medial frontal cortex of the rat.
Kanematsu
S
S
Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Ishii
S
S
Umino
A
A
Fujihira
T
T
Kashiwa
A
A
Yamamoto
N
N
Kurumaji
A
A
Nishikawa
T
T
D000818:Animals; D019540:Area Under Curve; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002951:Citrates / Q000633:toxicity; D045604:Extracellular Fluid / Q000737:chemistry* / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000187:drug effects / Q000378:metabolism*
D002951:Citrates; D005973:Glutamine; C007744:fluorocitrate; D012694:Serine