title: Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera.
abstract: An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 microg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
authors.affiliation: Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia, Lima, Perú.
authors.forename: Rosario
authors.initials: R
authors.lastname: Rojas
authors.forename: Luz
authors.initials: L
authors.lastname: Caviedes
authors.forename: José C
authors.initials: JC
authors.lastname: Aponte
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
authors.forename: Gerardo
authors.initials: G
authors.lastname: Lamas
authors.forename: César
authors.initials: C
authors.lastname: Sarasara
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000995:Antitubercular Agents; D014315:Triterpenes; C511675:aegicerin; C413246:oleanane; D009828:Oleanolic Acid