[In vitro chromosome aberration test and in vivo micronucleus test of Ca-type Garcinia extract].
The induction of chromosome aberration of Ca-type Garcinia cambogia extract containing about 65% (-)-hydroxycitric acid was investigated by use of the chromosome aberration test in cultured Chinese hamster lung cells (CHL/IU) and the micronucleus test in mice. In the chromosome aberration test, Ca-type Garcinia cambogia extract did not increase the number of cells with structural aberration and/or numerical aberrations. The micronucleus test was carried out with bone marrow cells of Slc : ddY male mice after single oral administration of up to 2,000 microg/kg. There was no significant increase in the frequency of micronucleated polychromatic erythrocytes. These results indicate that Ca-type Garcinia cambogia extract does not induce chromosome aberration.
Ono
Hiromi
H
Food Development Laboratories, Nippon Shinyaku Co Ltd, Kyoto, Japan.
Tamura
Hideyuki
H
Yamashita
Yasuhiro
Y
Tamura
Kouichi
K
Iwakura
Keiko
K
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000633:toxicity; D012668:Trigeminal Ganglion / Q000737:chemistry*
D010936:Plant Extracts