title: In vitro release of elements from prosthodontic base metal alloys: effect of protein-containing biologic environments.
abstract: OBJECTIVE
  This study aimed to investigate the release of nickel, copper, zinc, cadmium, magnesium, and lead from prosthodontic base metal alloys into protein-containing biologic solutions.
  
  
  METHODS
  Dissolution experiments were conducted in either 3% Dulbecco's Modified Eagle Medium or 3% bovine serum albumin solutions for 7 weeks.
  
  
  RESULTS
  The protein-containing dissolution solutions and dissolution time did not have a significant effect on release of elements from the alloys (Kruskal-Wallis, P > .05).
  
  
  CONCLUSIONS
  The amount of the released elements was well below the dietary intake levels of these elements. This study is important given the widespread use of the base metal alloys and the continuing public concerns/questions regarding the health benefits/risks associated with these materials.
authors.affiliation: Department of Restorative Dentistry, Leeds Dental Institute, University of Leeds, United Kingdom. n.efeoglu@leeds.ac.uk
authors.forename: Neslihan
authors.initials: N
authors.lastname: Efeoglu
authors.forename: Berran
authors.initials: B
authors.lastname: Ozturk
authors.forename: Canan
authors.initials: C
authors.lastname: Coker
authors.forename: Serdar
authors.initials: S
authors.lastname: Cotert
authors.forename: Memduh
authors.initials: M
authors.lastname: Bulbul
mesh_terms: D000818:Animals; D002104:Cadmium / Q000737:chemistry; D002417:Cattle; D002858:Chromium Alloys / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D003470:Culture Media; D003722:Dental Alloys / Q000737:chemistry*; D003819:Denture Bases; D007854:Lead / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012449:Safety; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012995:Solubility; D013997:Time Factors; D015032:Zinc / Q000737:chemistry
chemical_list: D002858:Chromium Alloys; D003470:Culture Media; D003722:Dental Alloys; D011506:Proteins; D002104:Cadmium; D012710:Serum Albumin, Bovine; D007854:Lead; D003300:Copper; D009532:Nickel; D008274:Magnesium; D015032:Zinc