title: Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
abstract: A group of new 10mer linear peptides, designated culicinins A-D (1-4), was isolated from the fermentation broth of the entomopathogenic fungus Culicinomyces clavisporus, strain LL-12I252. The structures of the culicinins were determined by a combination of 2D NMR and MS analysis. The major compound, culicinin D (4), exhibited selective inhibitory activity against PTEN-negative MDA468 tumor cells. Studies on the 3D structure of 4 using NOE data and computer modeling revealed a dominant conformation of the right-handed helix.
authors.affiliation: Wyeth Research, Pearl River, New York 10965, USA. heh@wyeth.com
authors.forename: Haiyin
authors.initials: H
authors.lastname: He
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Janso
authors.forename: Hui Y
authors.initials: HY
authors.lastname: Yang
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Bernan
authors.forename: Shuo L
authors.initials: SL
authors.lastname: Lin
authors.forename: Ker
authors.initials: K
authors.lastname: Yu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009518:New York; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054848:Peptaibols; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides; D054848:Peptaibols; C511568:culicinin D