title: Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia.
abstract: The chemokine MCP-1 is thought to play a key role - among many other pathophysiological processes - in myocardial infarction. MCP-1 is not only a key attractant for monocytes and macrophages and as such responsible for inflammation but might also be directly involved in the modulation of repair processes in the heart. We show that cultured human cardiac cells express MCP-1 and that its expression is upregulated by inflammatory cytokines and downregulated by hypoxia. We hypothesize that inflammation but not hypoxia is the main trigger for monocyte recruitment in the human heart.
authors.affiliation: Department of Internal Medicine II, Medical, University of Vienna, Austria.
authors.forename: Philipp J
authors.initials: PJ
authors.lastname: Hohensinner
authors.forename: Christoph
authors.initials: C
authors.lastname: Kaun
authors.forename: Kathrin
authors.initials: K
authors.lastname: Rychli
authors.forename: Enbal
authors.initials: E
authors.lastname: Ben-Tal Cohen
authors.forename: Stefan P
authors.initials: SP
authors.lastname: Kastl
authors.forename: Svitlana
authors.initials: S
authors.lastname: Demyanets
authors.forename: Stefan
authors.initials: S
authors.lastname: Pfaffenberger
authors.forename: Walter S
authors.initials: WS
authors.lastname: Speidl
authors.forename: Gersina
authors.initials: G
authors.lastname: Rega
authors.forename: Robert
authors.initials: R
authors.lastname: Ullrich
authors.forename: Gerald
authors.initials: G
authors.lastname: Maurer
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
authors.forename: Johann
authors.initials: J
authors.lastname: Wojta
mesh_terms: D015687:Cell Hypoxia / Q000502:physiology*; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018932:Chemokine CCL2; D018836:Inflammation Mediators