[Bone and bone related biochemical examinations. Bone and collagen related metabolites. Receptor activator of NF-kappaB ligand (RANKL)].
Identification of RANKL (receptor activator of NF-kappaB ligand), RANK (receptor activator of NF-kappaB) and OPG (osteoprotegerin) revealed the mechanisms regulating osteoclast differentiation and function. RANKL-RANK signaling is essential for the physiological osteoclast development and plays a major role in the pathological bone destruction. RANKL is a transmembrane protein, but soluble form (sRANKL) is circulated in blood stream. Change of sRANKL concentration was observed in several bone diseases. This paper reviews the potential of sRANKL measurement as a marker of bone diseases.
Yasuda
Hisataka
H
Oriental Yeast Co. Ltd, Nagahama Institute for Biochemical Science.
D015415:Biomarkers / Q000097:blood*; D001847:Bone Diseases / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood*; D010010:Osteoclasts / Q000502:physiology; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B
D015415:Biomarkers; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human