[The condition of the proteinase-antiproteinase system in patients with type II diabetes and chronic obstructive pulmonary disease].
Chronic obstructive pulmonary disease (COPD) and type II diabetes are major worldwide health problems. Proteinase-antiproteinase system (PAS) disbalance is known to play a significant role in COPD pathogenesis. There is increasing evidence concerning proteolysis activation as a factor of vascular complications. The subjects of this study were 130 individuals aged 39 to 68 years, divided into three groups. Group I consisted of 25 patients with type II diabetes, group 2--32 patients with type II diabetes and COPD, group 3--33 COPD patients, and group 4--40 apparently healthy people. Investigation of the PAS in these subjects demonstrated an important role of the condition of PAS in the development of COPD and type II diabetes, and a possible role of a hyposecretory mutation of alpha1-proteinase inhibitor gene as a risk factor of both bronchopulmonary and endocrine pathology.
Izmerov
N F
NF
Kuz'mina
L P
LP
Popkova
A M
AM
Khanykina
O V
OV
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D018450:Disease Progression; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010447:Peptide Hydrolases / Q000097:blood*; D016133:Polymerase Chain Reaction; D011480:Protease Inhibitors / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000201:enzymology*; D012307:Risk Factors; D000515:alpha 1-Antitrypsin / Q000235:genetics / Q000378:metabolism
D015415:Biomarkers; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D010447:Peptide Hydrolases