Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
A group of new 10mer linear peptides, designated culicinins A-D (1-4), was isolated from the fermentation broth of the entomopathogenic fungus Culicinomyces clavisporus, strain LL-12I252. The structures of the culicinins were determined by a combination of 2D NMR and MS analysis. The major compound, culicinin D (4), exhibited selective inhibitory activity against PTEN-negative MDA468 tumor cells. Studies on the 3D structure of 4 using NOE data and computer modeling revealed a dominant conformation of the right-handed helix.
He
Haiyin
H
Wyeth Research, Pearl River, New York 10965, USA. heh@wyeth.com
Janso
Jeffrey E
JE
Yang
Hui Y
HY
Bernan
Valerie S
VS
Lin
Shuo L
SL
Yu
Ker
K
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009518:New York; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054848:Peptaibols; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009842:Oligopeptides; D054848:Peptaibols; C511568:culicinin D