title: Triterpenic acids and flavonoids from Satureja parvifolia. Evaluation of their antiprotozoal activity.
abstract: Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9 microg/ml, luteolin 6.4 microg/ml, oleanolic acid 9.3 microg/ml and eriodictyol 17.2 microg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P. falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2 microg/ml) on the mammalian KB cell line.
authors.affiliation: Cátedra de Farmacognosia, Instituto de Química y Metabolismo del Fármaco IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, República Argentina.
authors.forename: Catalina
authors.initials: C
authors.lastname: van Baren
authors.forename: Ivie
authors.initials: I
authors.lastname: Anao
authors.forename: Paola
authors.initials: P
authors.lastname: Leo Di Lira
authors.forename: Silvia
authors.initials: S
authors.lastname: Debenedetti
authors.forename: Peter
authors.initials: P
authors.lastname: Houghton
authors.forename: Simon
authors.initials: S
authors.lastname: Croft
authors.forename: Virginia
authors.initials: V
authors.lastname: Martino
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D002738:Chloroquine / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D000432:Methanol; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D031362:Satureja / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000097245:Ursolic Acid
chemical_list: D000981:Antiprotozoal Agents; D002738:Chloroquine; D044950:Flavanones; D005419:Flavonoids; D000432:Methanol; D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid; C007619:eriodictyol