Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome.
OBJECTIVE
To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness.


METHODS
Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation.


RESULTS
Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p > or = .06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ.


CONCLUSIONS
Metformin during lactation appears to be safe and effective in the first 6 months of infancy.
Glueck
Charles J
CJ
Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com
Salehi
Marzieh
M
Sieve
Luann
L
Wang
Ping
P
D000328:Adult; D001903:Bottle Feeding; D001942:Breast Feeding; D002657:Child Development; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D041943:Infant Formula; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies
D007004:Hypoglycemic Agents; D008687:Metformin