title: Concentrations of estrone sulfate in peripheral serum of pregnant goats: Relationships with gestation length, fetal number and the occurrence of fetal death in utero.
abstract: Blood sampling was initiated shortly after breeding and continued weekly through 60 to 72 days post breeding in 20 pregnant and 5 nonpregnant dairy goat does. In does not showing a return to estrus by 72 days, collection of blood was continued at 10- to 14-day intervals until 135 days post breeding. At parturition, the numbers of does delivering one, two, three, four or five kids was four, ten, three, two and one, respectively. Immunoreactive estrone sulfate (ES) was measured in serum by radioimmunoassay (RIA). In nonpregnant does, the mean+/-SD concentration of ES was 0.1+/-0.1 nmol/l (n=36 samples). At 40 to 50 days post breeding, ES concentrations increased dramatically in pregnant does. Statistically, does were classified as pregnant when serum ES increased and remained above 1.1 nmol/l (P<0.05). Serum ES in pregnant does peaked at 65 to 75 days of gestation, remained at a relative plateau through 120 days and then gradually increased for the remainder of the sampling schedule. There were positive correlations between serum ES and the number of kids born in sampling periods of 50 to 55 days and after 90 days of gestation (P<0.05). Fetal loss was documented in two does that were not included in the survey data. One doe delivered two normal kids and two mummified fetuses. Time-trend changes in ES were typical of a normal pregnancy. Another doe had a marked decrease in ES (below 0.8 nmol/l) in samples drawn on Days 94 and 108 of gestation while luteal concentrations of progesterone were maintained. This doe delivered one weak, depressed kid, one stillborn kid and a decomposed fetus at the expected time for parturition.
authors.affiliation: Animal Health Diagnostic Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1316, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Refsal
authors.forename: J V
authors.initials: JV
authors.lastname: Marteniuk
authors.forename: C S
authors.initials: CS
authors.lastname: Williams
authors.forename: R F
authors.initials: RF
authors.lastname: Nachreiner