title: Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study.
abstract: A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.
authors.affiliation: University of Michigan, Ann Arbor, 48109-2054, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richler
authors.forename: Rhiannon
authors.initials: R
authors.lastname: Luyster
authors.forename: Susan
authors.initials: S
authors.lastname: Risi
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Hsu
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
authors.forename: Raphael
authors.initials: R
authors.lastname: Bernier
authors.forename: Michelle
authors.initials: M
authors.lastname: Dunn
authors.forename: Susan
authors.initials: S
authors.lastname: Hepburn
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hyman
authors.forename: William M
authors.initials: WM
authors.lastname: McMahon
authors.forename: Julie
authors.initials: J
authors.lastname: Goudie-Nice
authors.forename: Nancy
authors.initials: N
authors.lastname: Minshew
authors.forename: Sally
authors.initials: S
authors.lastname: Rogers
authors.forename: Marian
authors.initials: M
authors.lastname: Sigman
authors.forename: M Anne
authors.initials: MA
authors.lastname: Spence
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Goldberg
authors.forename: Helen
authors.initials: H
authors.lastname: Tager-Flusberg
authors.forename: Fred R
authors.initials: FR
authors.lastname: Volkmar
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D002648:Child; D003142:Communication; D005260:Female; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D015588:Observer Variation; D010290:Parents; D010641:Phenotype; D012043:Regression, Psychology; D012919:Social Behavior; D011795:Surveys and Questionnaires
chemical_list: D022542:Measles-Mumps-Rubella Vaccine