Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.
Kaeberlein
Matt
M
Department of Pathology, University of Washington, Seattle, WA 98195, USA. kaeber@u.washington.edu
Steffen
Kristan K
KK
Hu
Di
D
Dang
Nick
N
Kerr
Emily O
EO
Tsuchiya
Mitsuhiro
M
Fields
Stanley
S
Kennedy
Brian K
BK
D031204:Caloric Restriction; D005947:Glucose / Q000378:metabolism; D006655:Histone Deacetylases / Q000502:physiology*; D008136:Longevity; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000502:physiology*; D056565:Sirtuin 2; D037761:Sirtuins / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C423033:HST2 protein, S cerevisiae; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases; D005947:Glucose