title: New polyhydroxylated triterpenes and anti-inflammatory activity of Salvia hierosolymitana.
abstract: Salvia hierosolymitana (Lamiaceae) leaves were investigated for their topical anti-inflammatory properties following a bioassay-guided fractionation. The chloroform extract showed a strong inhibition of the Croton oil-induced ear oedema in mice, comparable to that of indomethacin. Phytochemical and pharmacological investigations of this extract led to the isolation of eight anti-inflammatory polyhydroxylated triterpenes of the ursane and oleanane series. Four of them are new compounds, whose structures were elucidated by NMR and mass spectroscopy as 3beta, 6alpha,23-trihydroxyurs-12,19(29)-dien-28-oic acid, 23-( TRANS-P-coumaroyloxy)-3beta, 6alpha,30-trihydroxyurs-12-en-28-oic acid, 2alpha,3beta-dihydroxyolean-28-oic acid and 24-nor-2alpha,3beta-dihydroxyolean-4(23),12-ene.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Felice
authors.forename: A
authors.initials: A
authors.lastname: Bader
authors.forename: A
authors.initials: A
authors.lastname: Leone
authors.forename: S
authors.initials: S
authors.lastname: Sosa
authors.forename: R Della
authors.initials: RD
authors.lastname: Loggia
authors.forename: A
authors.initials: A
authors.lastname: Tubaro
authors.forename: N
authors.initials: N
authors.lastname: De Tommasi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D003872:Dermatitis / Q000188:drug therapy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D027544:Salvia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes