Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia.
Oblongifolins A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam. The bark was also found to contain the known compounds camboginol and guttiferone B. Extraction of the leaves gave 2 and camboginol. Details of the structure elucidation of 2-5 and stereochemical comparisons with known natural derivatives of general formula 1a,b are presented. The biological activity of these compounds concerning interactions with tubulin was investigated.
Hamed
Wafaa
W
Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Brajeul
Solenn
S
Mahuteau-Betzer
Florence
F
Thoison
Odile
O
Mons
Stéphane
S
Delpech
Bernard
B
Nguyen
Van Hung
VH
Sévenet
Thierry
T
Marazano
Christian
C
D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000302:isolation & purification; D014404:Tubulin / Q000187:drug effects; D014744:Vietnam
D013729:Terpenes; D014404:Tubulin; D010696:Phloroglucinol; C054597:garcinol