Kinin receptor expression during Staphylococcus aureus infection.
An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg(9)bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections.
Bengtson
Sara H
SH
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Tornavägen 10, SE-221 84 Lund, Sweden.
Phagoo
Stephen B
SB
Norrby-Teglund
Anna
A
Påhlman
Lisa
L
Mörgelin
Matthias
M
Zuraw
Bruce L
BL
Leeb-Lundberg
L M Fredrik
LM
Herwald
Heiko
H
D000942:Antigens, Bacterial / Q000633:toxicity; D001483:Base Sequence; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis; D004247:DNA / Q000235:genetics; D006801:Humans; D016253:Microscopy, Immunoelectron; D008954:Models, Biological; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D043783:Receptor, Bradykinin B1 / Q000235:genetics / Q000378:metabolism*; D043782:Receptor, Bradykinin B2 / Q000235:genetics / Q000378:metabolism*; D013203:Staphylococcal Infections / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D018089:Superantigens / Q000633:toxicity
D000942:Antigens, Bacterial; D016207:Cytokines; D012333:RNA, Messenger; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D018089:Superantigens; D004247:DNA