PAMAM dendrimers for efficient siRNA delivery and potent gene silencing.
Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
Zhou
Jiehua
J
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Wu
Jiangyu
J
Hafdi
Nadia
N
Behr
Jean-Paul
JP
Erbacher
Patrick
P
Peng
Ling
L
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D020868:Gene Silencing; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D034741:RNA, Small Interfering