title: Radial scar lesions of the breast diagnosed by needle core biopsy: analysis of cases containing occult malignancy.
abstract: OBJECTIVE
  To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision.
  
  
  RESULTS
  A total of 11 false negative NCB in RS/CSL lesions from 281 (3.9%) were identified (6 cases: B1, 2 cases: B2 and 3 cases: B3). In 6 of 11 cases a radial scar or stromal sclerosis was seen in NCB. Localisation biopsy showed duct carcinoma in situ in six cases, duct carcinoma in situ with invasive carcinoma in three and invasive carcinoma in two. In all 11 cases, needle tracks were identified as missing the malignant epithelium by a mean of 5 mm (median:4 mm; range:1-20 mm). In 9 of 11 cases, the malignancy was missed by <6 mm.
  
  
  CONCLUSIONS
  Despite evidence of accurate targeting of lesions, the use of NCB instead of fine needle aspiration cytology has not eliminated the problem of false negative biopsy in RS/CSL, and excision is recommended.
authors.affiliation: Department of Pathology, School of Medicine, Cardiff University, Cardiff, UK. douglas-jones@cf.ac.uk
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Douglas-Jones
authors.forename: Jemimah L
authors.initials: JL
authors.lastname: Denson
authors.forename: Adam C
authors.initials: AC
authors.lastname: Cox
authors.forename: Iwan B
authors.initials: IB
authors.lastname: Harries
authors.forename: Guy
authors.initials: G
authors.lastname: Stevens
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008403:Mass Screening