Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits that functions as a master regulator of oxygen homeostasis. Oxygen-dependent hydroxylation of HIF-1alpha provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. Hypoxia-inducible factor 1 plays critical roles in development, physiology and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1alpha subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.
Semenza
Gregg L
GL
Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gsemenza@jhmi.edu
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002344:Carotid Body / Q000502:physiology; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000502:physiology*; D051379:Mice; D010100:Oxygen / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D012143:Respiratory Physiological Phenomena
D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen