Treatment of ovariectomized ewes with bovine follicular fluid decreases secretion of FSH without changing secretion of LH.
Ovariectomized ewes were injected with 0, 0.25, 0.5, 1.0 or 2.0 ml of charcoal-extracted bovine follicular fluid. Treating ewes with 2 ml of follicular fluid resulted in a decrease in circulating concentrations of FSH to 72.8% of the pretreatment value. With smaller doses of follicular fluid, the magnitude of the decrease was less. Concentrations of LH did not change significantly. Pretreatment of ovariectomized ewes with estradiol and/or progestogen did not alter the magnitude of the FSH decrease. This action of follicular fluid extract fits the effect of the non-steroidal substance known as inhibin or folliculostatin.
Miller
K F
KF
U.S. Department of Agriculture Reproduction Laboratory, Animal Science Institute, Agricultural Research Service Beltsville Agricultural Research Center Beltsville, MD 20705 USA.
Bolt
D J
DJ