title: [Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population].
abstract: OBJECTIVE
  This case-control study was designed to detect the association between STK15 Phe31Ile polymorphism and colorectal cancer.
  
  
  METHODS
  Genotypes were determined in 283 patients with colorectal cancer and 283 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.
  
  
  RESULTS
  The frequency of the STK15 Ile/Ile genotype was significantly higher in cancer cases than in controls (50.2% vs. 36.8%; P = 0.02). Subjects with the Ile/Ile genotype had an increased risk for the occurrence of colorectal cancer compared with those with the STK15 Phe/Phe genotype (adjusted OR, 1.92; 95% CI, 1.13 - 3.27). No significant association was observed between this STK15 polymorphism and risk of metastasis of the cancer.
  
  
  CONCLUSIONS
  These findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.
authors.affiliation: Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Shi-ning
authors.initials: SN
authors.lastname: Qu
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Ping
authors.initials: P
authors.lastname: Xiong
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D064096:Aurora Kinase A; D064127:Aurora Kinases; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D012004:Rectal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases