title: Galectin-3 and Ki-67 expression in multiglandular parathyroid lesions.
abstract: Hyperplastic and neoplastic parathyroid lesions may present overlapping morphologic features, and several markers have been proposed to distinguish benign from malignant growths. Recently, it was reported that galectin-3 is a useful marker of malignancy in uniglandular parathyroid diseases. To investigate galectin-3 and Ki-67 immunoexpression in parathyroid hyperplastic disease, 63 multiglandular lesions (13 primary, 40 secondary, and 10 tertiary hyperplasia cases) were analyzed and compared with 45 control cases of parathyroid adenomas and 24 carcinomas. Our data showed that hyperplastic lesions responsible for primary nonfamilial or tertiary hyperparathyroidism, as well as parathyroid adenomas, were negative for galectin-3, as opposed to carcinomas. In addition, secondary and familial primary hyperplasia cases were surprisingly positive for galectin-3 in approximately two thirds of cases. All hyperplastic lesions (positive or negative for galectin-3) had a low Ki-67 index. Based on these findings, secondary hyperplasia has a low proliferative potential but an unexplained galectin-3 reactivity, which reduces its diagnostic role in differentiating benign from malignant nodules in the context of multiglandular parathyroid diseases.
authors.affiliation: Section of Endocrinology, University of Turin, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Saggiorato
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bergero
authors.forename: Marco
authors.initials: M
authors.lastname: Volante
authors.forename: Elisa
authors.initials: E
authors.lastname: Bacillo
authors.forename: Rosj
authors.initials: R
authors.lastname: Rosas
authors.forename: Guido
authors.initials: G
authors.lastname: Gasparri
authors.forename: Fabio
authors.initials: F
authors.lastname: Orlandi
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D006961:Hyperparathyroidism / Q000378:metabolism / Q000473:pathology; D006965:Hyperplasia; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010280:Parathyroid Glands / Q000378:metabolism* / Q000473:pathology; D010282:Parathyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3; D019394:Ki-67 Antigen