title: The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective.
abstract: Musculoskeletal repair is a major challenge for orthopaedic surgeons. The burden of repair is compounded by supply constraints and morbidity associated with autograft and allograft tissue. We report 15 years of research regarding tissue engineering and biological substitutes for bone and ligaments. Our approach has focused on biomaterial selection, scaffold development, cell selection, cell/material interaction, and growth factor delivery. We have extensively tested poly(ester), poly(anhydride), poly(phosphazene) derivatives, and composite materials using biocompatibility, degradation, and mechanical analyses for bone and ligament tissue engineering. We have developed novel three-dimensional matrices with a pore structure and mechanical properties similar to native tissue. We also have reported on the attachment, growth, proliferation, and differentiation of cells cultured on several scaffolds. Through extensive molecular analysis, in vitro culture condition analysis, and in vivo evaluation, our findings provide new methods of bone tissue regeneration using three-dimensional tissue engineered scaffolds, bioactive bone cement composite materials, and three-dimensional tissue engineered scaffolds for ligament regeneration.
authors.affiliation: Laurencin Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. ctl3f@virginia.edu
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Khan
authors.forename: Michele
authors.initials: M
authors.lastname: Kofron
authors.forename: Saadiq
authors.initials: S
authors.lastname: El-Amin
authors.forename: Edward
authors.initials: E
authors.lastname: Botchwey
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yu
authors.forename: James A
authors.initials: JA
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D001842:Bone and Bones; D005544:Forecasting; D006801:Humans; D008022:Ligaments; D051379:Mice; D016513:Mice, SCID; D009140:Musculoskeletal Diseases / Q000503:physiopathology / Q000628:therapy; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000592:standards* / Q000639:trends