title: Homocysteine and risk of developing hypertension in men.
abstract: In cross-sectional studies, elevated homocysteine levels are associated with higher blood pressure, but it remains unclear whether plasma homocysteine is a risk factor for hypertension. In a prospective nested case-control study, participants who developed hypertension (n=396) had significantly higher levels of baseline plasma homocysteine (12.6 mol/l) than matched controls (11.8 mol/l, P=0.03); compared to those in the lowest quintile, those in the highest quintile had a crude relative risk (RR) of 1.56 (95% confidence interval (CI), 0.98-2.48; P for trend=0.10) and a multivariable RR of 1.63 (95% CI, 0.97-2.74; P for trend=0.13). Higher plasma homocysteine levels at baseline were associated with an increased but non-significant risk of incident hypertension that was minimally affected by multivariable adjustment.
authors.affiliation: Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA, USA. tsbowman@partners.org
authors.forename: T S
authors.initials: TS
authors.lastname: Bowman
authors.forename: J M
authors.initials: JM
authors.lastname: Gaziano
authors.forename: M J
authors.initials: MJ
authors.lastname: Stampfer
authors.forename: H D
authors.initials: HD
authors.lastname: Sesso
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D006710:Homocysteine