Update on endogenous inhibitors of angiogenesis.
Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the family of angiogenesis stimulators, i.e., vascular endothelial growth factor family proteins and angiopoietins. These factors act on endothelial cells to stimulate angiogenesis. In contrast, most of angiogenesis inhibitors do not seem to have such characteristics. Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis.
Sato
Yasufumi
Y
Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp
D020533:Angiogenesis Inhibitors / Q000502:physiology*; D042501:Angiogenic Proteins / Q000502:physiology; D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010447:Peptide Hydrolases / Q000502:physiology
D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D010447:Peptide Hydrolases