Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy.
Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58-year-old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post-transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non-native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T-antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN.
Weinreb
David B
DB
Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA. david.weinreb@mssm.edu
Desman
Garrett T
GT
Burstein
David E
DE
Dikman
Steven H
SH
Johnson
Edward M
EM
D000952:Antigens, Polyomavirus Transforming / Q000032:analysis; D001706:Biopsy; D003556:Cystitis / Q000209:etiology / Q000473:pathology / Q000821:virology*; D003928:Diabetic Nephropathies / Q000601:surgery; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology / Q000473:pathology / Q000821:virology*; D011120:Polyomavirus / Q000276:immunology*; D027601:Polyomavirus Infections / Q000209:etiology / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000209:etiology / Q000473:pathology / Q000821:virology*
D000952:Antigens, Polyomavirus Transforming