Novel synthesis of pyrrolo [2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents.
A novel series of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties have been synthesized and tested for their antitumor activity. Among them, compounds 4, 8b, Bd, 8g and 14 showed promising antitumor activity. Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data.
Ismail
Magda M E
MM
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. magda_f_ismail@yahoo.com
Ghorab
Mostafa M
MM
Noaman
Eman
E
Ammar
Yousry A
YA
Heiba
Helmy I
HI
Sayed
Marwa Y
MY
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000532:radiotherapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009368:Neoplasm Transplantation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000097:blood; D016019:Survival Analysis
D000970:Antineoplastic Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D011743:Pyrimidines; D011758:Pyrroles; D011837:Radiation-Protective Agents; D013482:Superoxide Dismutase; D005978:Glutathione