[The serum level transformation of interleukin 18 before and after SIT in patients with allergic rhinitis].
OBJECTIVE
To survey the role of IL-18 in the pathogenesis of allergic rhinitis, and to discuss the mechanism of specific immunotherapy (SIT).


METHODS
The serum levels of IL-18 in patients with allergic rhinitis and the health control were detected by ELISA before and after SIT (for l year).


RESULTS
The levels of IL-18 in patients before SIT were (88.33 +/- 35. 95)ng/L, significantly lower than that in healthy control(149 +/- 47.37)ng/L, and the level after SIT (199.22 +/- 58.82 )ng/L was significantly higher than that before SIT. There was no significant difference between the healthy after-SIT.


CONCLUSIONS
IL-18 plays an important role in the pathogenesis of allergic inflammation and the SIT therapy.
Li
Wenjing
W
Department of Allergy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu
Guanghui
G
Zhu
Rongfei
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000628:therapy; D016022:Case-Control Studies; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000628:therapy; D055815:Young Adult
D020382:Interleukin-18