title: Synthesis and biological evaluation of type VI beta-turn templated RGD peptidomimetics.
abstract: We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI beta-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors alphavbeta3 and alphavbeta5. The results demonstrate the utility of these type VI beta-turn scaffolds for the constraint of biologically relevant peptides.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, Box 0776, Welsh and McKean Roads, Spring House, PA 19477-0776, USA. ccreight@prdus.jnj.com
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Creighton
authors.forename: Yanming
authors.initials: Y
authors.lastname: Du
authors.forename: Rosemary J
authors.initials: RJ
authors.lastname: Santulli
authors.forename: Brett A
authors.initials: BA
authors.lastname: Tounge
authors.forename: Allen B
authors.initials: AB
authors.lastname: Reitz
mesh_terms: D008958:Models, Molecular; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid