title: Eclampsia : before and after magnesium sulphate.
abstract: This study was done to see the incidence and impact of changes in the intervention strategy for the management of eclampsia in a maternity hospital on maternal and perinatal outcome. Analysis of case records of all eclampsia cases over two different study periods designated as study period A (April, 1994 to Oct, 1996) and study period B (April, 2000 to April, 2001) were done. Total number of eclampsia cases who received intervention over two different study period (46 in study period A and 47 in study period B) were comparable despite the difference in the duration of study period. During study period A, diazepam was used as anticonvulsant, whereas magnesium sulphate was used to control fits during study period B. Incidence of eclampsia has markedly increased in this hospital (0.12% vs 0.29%). Epidemiology and clinical profile of eclamptic patients do not show remarkable change. There was no maternal death in study period B (April, 2000 to April, 2001) whereas there was one maternal death in the study period A (April, 1994 to October, 1996). Marked improvement was noticed in terms of recurrence of fit (19.13% vs 73.91%) with change in the intervention strategy. Perinatal deaths were fewer in study period B (20% vs 33%). Overall, it seems that care of eclamptic patients and use of magnesium sulphate as anticonvulsant has resulted in positive impact on maternal outcome.
authors.affiliation: Maternity Hospital, Thapathali, Kathmandu, Nepal.
authors.forename: P
authors.initials: P
authors.lastname: Chaudhary
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D006771:Hospitals, Maternity / Q000706:statistics & numerical data; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D009390:Nepal / Q000453:epidemiology; D009543:Nifedipine / Q000627:therapeutic use; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D050497:Stillbirth / Q000453:epidemiology; D015149:Tocolytic Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D009543:Nifedipine; D003975:Diazepam