Phenolic compounds from the roots of Lindera fruticosa.
The phenolic compounds isolated from the roots of Lindera fruticosa included four new compounds, 2-methoxy-3,4-methylenedioxybenzophenone (1), (S)-2-methoxy-3,4-methylenedioxybenzhydryl alcohol (2), 3-hydroxy-5-methoxybiphenyl (3), and 1-methoxy-2,5,7-trihydroxyxanthone (4). Three previously identified phenolics were also identified, namely, 3,5-dimethoxybiphenyl (5), benzyl 2-hydroxy-6-methoxybenzoate (6), and 1,7-dihydroxyxanthone (7). These compounds were evaluated for their inhibitory effects on human acyl-CoA:cholesterol acyltransferase activity and on the in vitro oxidation of low-density lipoprotein.
Song
Myoung-Chong
MC
Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon 449-701, Korea.
Nigussie
Fikru
F
Jeong
Tae-Sook
TS
Lee
Chang-Yong
CY
Regassa
Fekadu
F
Markos
Takele
T
Baek
Nam-In
NI
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005002:Ethiopia; D006801:Humans; D027443:Lindera / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000187:drug effects*; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D008077:Lipoproteins, LDL; D010636:Phenols; D002785:Sterol O-Acyltransferase