title: Induction of protection against porcine cysticercosis in growing pigs by DNA vaccination.
abstract: A DNA vaccine, pcDNA3-B, was developed by using the nucleotide sequence of Taenia solium B antigen and cloning into pcDNA3.1 plasmid. The growing pigs were vaccinated by one intramuscular infection of 200 or 1000 microg pcDNA3-B. The immunization with 1000 microg of pcDNA3-B showed 92.6% protection when the pigs were challenged by T. solium eggs and four of the five pigs vaccinated had no viable cysts. The results provide encouraging information on the use of pcDNA3-B vaccination for the prevention of cysticercosis.
authors.affiliation: Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu 730046, China.
authors.forename: Aijiang
authors.initials: A
authors.lastname: Guo
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Jin
authors.forename: Yadong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Gang
authors.initials: G
authors.lastname: Hai
authors.forename: Gailing
authors.initials: G
authors.lastname: Yuan
authors.forename: Hailong
authors.initials: H
authors.lastname: Li
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Cai
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D008213:Lymphocyte Activation; D051379:Mice; D013552:Swine / Q000254:growth & development; D013553:Swine Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D014335:Tropomyosin / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination / Q000662:veterinary; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D014335:Tropomyosin; D019444:Vaccines, DNA