Aging at the interface of stem cell renewal, apoptosis, senescence, and cancer.
The aging-related research field has focused on the detection of genetic factors that affect the aging process, but more recently scientists have started to shift their attention to novel and more integrative ways of studying cellular and organismal function. Such approaches allow them to uncover and explore unexpected patterns and themes, resulting in a more comprehensive knowledge of the complex regulatory pathways and networks involved in aging and age-related diseases. Eventually, this knowledge will lead to a systems-level understanding of aging. The third "Functional Genomics of Aging" conference held in Palermo, Italy, in March/April 2006 highlighted some of the more exciting work in this area.
Nebel
Almut
A
Institute of Clinical Molecular Biology, University of Kiel, Germany.
Schaffitzel
Elke
E
Hertweck
Maren
M
D000375:Aging / Q000235:genetics / Q000502:physiology*; D017209:Apoptosis; D016922:Cellular Senescence; D044127:Epigenesis, Genetic; D006801:Humans; D008136:Longevity; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology*; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology*