title: The prognosis significance of insulin secretion in liver cirrhosis.
abstract: We evaluate the prognostic significance of chronic liver diseases followed by diabetes mellitus in 40 patients by Child class, immunoreactive insulinemia (IRI), C peptide (CP) and pancreolaury-test (PLT) at 5 years. Death and hepatic insufficiency prevalence were significantly higher in cirrhotic diabetics, and in those diabetics with a lower insulin secretion (IRI, CP). Insulin hyposecretion (lower IRI, CP) was found in cirrhotic with abnormal PLT (below 20%). The onset of diabetes mellitus in liver cirrhosis has a bad prognosis when it is caused by decreased insulin secretion produced by chronic pancreatitis or pancreatic insufficiency.
authors.affiliation: 4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Sâmpelean
authors.forename: Nicoleta
authors.initials: N
authors.lastname: Leach
authors.forename: Ioana
authors.initials: I
authors.lastname: Suciu
mesh_terms: D002096:C-Peptide / Q000097:blood; D003920:Diabetes Mellitus / Q000209:etiology* / Q000401:mortality; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D008137:Longitudinal Studies; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D002096:C-Peptide; D007328:Insulin