Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil.
The physiologic variability of blood flow to the prostate has not been studied until this time. We report the vasoactive effects of sildenafil and phenylephrine on blood flow of the normal prostate. Sildenafil increases prostate blood flow by approximately 75% and phenylephrine reduces the flow incrementally. Administration of these drugs with dynamic contrast-enhanced magnetic resonance imaging may improve the diagnosis of cancerous tissue because according to the literature, tumor angiogenic vessels lack the vasoactive physiologic response of the normal tissue.
Haaga
J R
JR
Department of Radiology, University Hospitals of Cleveland, Cleveland, OH 44106, USA. Haaga@UHRAD.com
Exner
A
A
Fei
B
B
Seftel
A
A
D001783:Blood Flow Velocity / Q000187:drug effects; D004809:Ephedrine / Q000494:pharmacology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011467:Prostate / Q000098:blood supply*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D004809:Ephedrine