Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment.
The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.
Cotta
Claudiu V
CV
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA.
Konoplev
Sergej
S
Medeiros
L Jeffrey
LJ
Bueso-Ramos
Carlos E
CE
D014408:Biomarkers, Tumor / Q000032:analysis; D001854:Bone Marrow Cells / Q000737:chemistry / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000737:chemistry / Q000556:secondary*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual / Q000175:diagnosis
D014408:Biomarkers, Tumor