title: Sarcophytonolides E-H, cembranolides from the Hainan soft coral Sarcophyton latum.
abstract: Four new cembrane diterpenes, sarcophytonolides E-H (1-4), were isolated from the Hainan soft coral Sarcophyton latum. Their structures were elucidated by detailed spectroscopic (IR, MS, 2D NMR) analysis and by comparison with related known compounds. The absolute stereochemistry of sarcophytonolide H (4) was determined by applying the modified Mosher's method.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jia
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured
chemical_list: D004224:Diterpenes