title: Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.
abstract: 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.
authors.affiliation: Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com
authors.forename: Chamakura V N S
authors.initials: CV
authors.lastname: Varaprasad
authors.forename: Dinesh
authors.initials: D
authors.lastname: Barawkar
authors.forename: Hassan
authors.initials: H
authors.lastname: El Abdellaoui
authors.forename: Subrata
authors.initials: S
authors.lastname: Chakravarty
authors.forename: Matthew
authors.initials: M
authors.lastname: Allan
authors.forename: Huanming
authors.initials: H
authors.lastname: Chen
authors.forename: Weijian
authors.initials: W
authors.lastname: Zhang
authors.forename: Jim Z
authors.initials: JZ
authors.lastname: Wu
authors.forename: Robert
authors.initials: R
authors.lastname: Tam
authors.forename: Robert
authors.initials: R
authors.lastname: Hamatake
authors.forename: Stanley
authors.initials: S
authors.lastname: Lang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Hong
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D048369:MAP Kinase Kinase 1 / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013844:Thiazoles; D048369:MAP Kinase Kinase 1