title: Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants.
abstract: OBJECTIVE
  To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal skin maturation.
  
  
  METHODS
  In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH.
  
  
  RESULTS
  TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days, TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m2 h) than in those nursed at 50% RH (13 +/- 1 g/m2 h; P < .001).
  
  
  CONCLUSIONS
  The results indicate that the level of RH influences skin barrier development, with more rapid barrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting skin barrier integrity in extremely preterm infants.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. johan.agren@kbh.uu.se
authors.forename: Johan
authors.initials: J
authors.lastname: Agren
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sjörs
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sedin
mesh_terms: D005260:Female; D006801:Humans; D006813:Humidity; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight / Q000097:blood / Q000254:growth & development*; D008297:Male; D018529:Nutritional Support; D012867:Skin / Q000254:growth & development*; D012964:Sodium / Q000097:blood; D014870:Water Loss, Insensible
chemical_list: D012964:Sodium