A new twist in Smad signaling.
Signaling by members of the TGFbeta family is much dependent on the common-mediator Smad4, which forms transcriptionally active complexes with all receptor-activated Smads (R-Smads). New findings demonstrate that transcriptional intermediary factor 1gamma (TIF1gamma) also can bind to R-Smads, as an alternative to Smad4, and mediate different transcriptional effects.
Heldin
Carl-Henrik
CH
Ludwig Institute for Cancer Research, Uppsala University, Box 595, SE-751 24 Uppsala, Sweden.
Moustakas
Aristidis
A
D008954:Models, Biological; D020239:Receptor Cross-Talk; D015398:Signal Transduction; D051901:Smad4 Protein / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D051879:Twist-Related Protein 1 / Q000378:metabolism*
D051901:Smad4 Protein; D016212:Transforming Growth Factor beta; D051879:Twist-Related Protein 1