Suppression of cell and platelet adhesion to star-shaped 8-armed poly(ethylene glycol)-poly(L-lactide) block copolymer films.
To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet anti-adhesion properties of such a hydrated film are investigated. Based on the results, it is found that the 8-armed PEG35K-b-PLLA37K film exhibits a biologically inert surface, which is the result of a large number of PEG chains and a free water layer on the film surface. This leads to a reduction in protein absorption and cell and platelet adhesion onto the film surface. This implies that the star-shaped 8-armed PEG35K-b-PLLA37K film can be utilized as a novel bioabsorbable adhesion-prevention membrane.
Nagahama
Koji
K
Department of Applied Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University, Suita, Osaka 564-8680, Japan.
Ohya
Yuichi
Y
Ouchi
Tatsuro
T
D000042:Absorption; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects*; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols