title: Polytetrafluoroethylene/polylactide-co-glycolide laminate containing dexamethasone allows delayed adjustable strabismus surgery in a rabbit model.
abstract: OBJECTIVE
  To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery.
  
  
  METHODS
  A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA containing or not containing dexamethasone or balanced saline solution was applied beneath and over the SRM in the three treatment groups: the PTFE/PLGA-dexamethasone group (the P-D group), the PTFE group (the P group), and the control group (group C). Delayed adjustment was performed once on each SRM at 3 or 5 weeks after surgery by a masked observer. Adjustment lengths, the forces required, and degrees of adhesions were evaluated.
  
  
  RESULTS
  In the control group, adjustment was possible in no eyes at 3 or 5 weeks after surgery. In group P, adjustment was possible in 6 of 10 eyes at 3 weeks after surgery and in 4 of 9 eyes at 5 weeks after surgery. In group P-D, adjustment was possible in 7 of 9 eyes at 3 and 5 weeks after surgery.
  
  
  CONCLUSIONS
  PTFE/PLGA containing dexamethasone was found to allow delayed adjustment in most eyes for up to 5 weeks after surgery without instillation of anti-inflammatory agent.
authors.affiliation: National Research Lab for Drug and Gene Delivery, College of Pharmacy, Seoul National University, and Seoul National University Boramae Hospital, Korea.
authors.forename: Jun-Pil
authors.initials: JP
authors.lastname: Jee
authors.forename: Ho-Kyung
authors.initials: HK
authors.lastname: Choung
authors.forename: Chong-Kook
authors.initials: CK
authors.lastname: Kim
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004337:Drug Carriers; D019344:Lactic Acid; D009801:Oculomotor Muscles / Q000601:surgery*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011817:Rabbits; D015422:Scleral Diseases / Q000517:prevention & control; D013285:Strabismus / Q000601:surgery*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone; D011138:Polytetrafluoroethylene