title: Retinal cone mosaic imaged with transverse scanning optical coherence tomography.
abstract: We improved our recently reported retinal OCT system based on transverse priority scanning to achieve high resolution in both the transverse and the axial directions. The implementation of an additional SLO channel enables precise on-line focusing. The system enables imaging of the human retinal cone mosaic off the foveal center without adaptive optics. We demonstrate, for what is believed to be the first time, cone mosaic imaging simultaneously in the scanning laser ophthalmoscope and optical coherence tomography (OCT) channels. OCT B-scan images demonstrate that the cone mosaic is observable in two adjacent layers. Furthermore, we present what are believed to be the first C-scan OCT images of the cone mosaic and show that the major part of light backscattered from below the photoreceptor layer is not guided back toward the pupil by the photoreceptors.
authors.affiliation: Center for Biomedical Engineering and Physics, Medical University of Vienna, Währinger Strasse 13, A-1090 Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Pircher
authors.forename: Bernhard
authors.initials: B
authors.lastname: Baumann
authors.forename: Erich
authors.initials: E
authors.lastname: Götzinger
authors.forename: Christoph K
authors.initials: CK
authors.lastname: Hitzenberger
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D009415:Nerve Net / Q000166:cytology*; D015203:Reproducibility of Results; D017949:Retinal Cone Photoreceptor Cells / Q000648:ultrastructure*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods