Synthesis and biological evaluation of 1beta-methylcarbapenems having cyclic thiourea moieties and their related compounds.
The synthesis of a new series of 1beta-methylcarbapenems having cyclic thiourea moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIId) having piperazine thiourea moiety showed the most potent antibacterial activity.
Han
T
T
Hawon Pharm. Co., Seoul, South Korea.
Cho
J-H
JH
Oh
C-H
CH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003500:Cyclization; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry*
C476323:1 beta-methylcarbapenem; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013890:Thiourea