title: Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice.
abstract: The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0 mg/kg for 13 days--Experiment 1) or saline or ETOH (1.8 g/kg for 21 days--Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages--HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages--HET-HC). Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. In both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior.
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: N P
authors.initials: NP
authors.lastname: Araujo
authors.forename: D F
authors.initials: DF
authors.lastname: Fukushiro
authors.forename: J L S
authors.initials: JL
authors.lastname: Cunha
authors.forename: R
authors.initials: R
authors.lastname: Levin
authors.forename: C C
authors.initials: CC
authors.lastname: Chinen
authors.forename: R C
authors.initials: RC
authors.lastname: Carvalho
authors.forename: I C P
authors.initials: IC
authors.lastname: Ribeiro
authors.forename: D C
authors.initials: DC
authors.lastname: Gomes
authors.forename: V C
authors.initials: VC
authors.lastname: Abílio
authors.forename: R H
authors.initials: RH
authors.lastname: Silva
authors.forename: R de A
authors.initials: Rde A
authors.lastname: Ribeiro
authors.forename: R
authors.initials: R
authors.lastname: Frussa-Filho
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D051379:Mice
chemical_list: D000431:Ethanol; D000661:Amphetamine