title: Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis.
abstract: The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.
authors.affiliation: Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Harumi
authors.initials: H
authors.lastname: Hata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Harano
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Tokutaro
authors.initials: T
authors.lastname: Komiyama
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Masanari
authors.initials: M
authors.lastname: Itokawa
authors.forename: Maki
authors.initials: M
authors.lastname: Naka
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ide
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
authors.forename: Yohtaro
authors.initials: Y
authors.lastname: Numachi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D017465:Receptors, Opioid, delta / Q000235:genetics*
chemical_list: D017465:Receptors, Opioid, delta; D008694:Methamphetamine