title: 14-3-3 proteins as potential oncogenes.
abstract: 14-3-3 proteins are a family of highly conserved cellular proteins that play key roles in the regulation of central physiological pathways. More than 200 14-3-3 target proteins have been identified, including proteins involved in mitogenic and cell survival signaling, cell cycle control and apoptotic cell death. Importantly, the involvement of 14-3-3 proteins in the regulation of various oncogenes and tumor suppressor genes points to a potential role in human cancer. The present review summarizes current findings implicating a 14-3-3 role in cancer while discussing potential mechanisms and points of action of 14-3-3 during cancer development and progression.
authors.affiliation: Karmanos Cancer Institute and Department of Pathology, Wayne State University, Detroit, MI 48201, USA. tziviong@karmanos.org
authors.forename: Guri
authors.initials: G
authors.lastname: Tzivion
authors.forename: Vinita Singh
authors.initials: VS
authors.lastname: Gupta
authors.forename: Ludmila
authors.initials: L
authors.lastname: Kaplun
authors.forename: Vitaly
authors.initials: V
authors.lastname: Balan
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015513:Oncogene Proteins / Q000378:metabolism*; D009857:Oncogenes / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D048948:14-3-3 Proteins; D018797:Cell Cycle Proteins; D015513:Oncogene Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins