title: Sister Mary Joseph's nodule as presenting sign of a desmoplastic small round cell tumor.
abstract: Umbilical metastases, also named Sister Mary Joseph's nodules, are well documented in the adult population and most often represent an underlying intra-abdominal malignancy, usually a carcinoma of gastrointestinal or gynecologic origin. They are indicative of widespread abdominal disease and are associated with a poor prognosis. An extensive review of the literature reveals only two such presentations in the pediatric population. A 14-year-old male presented with an umbilical mass, which was found to be a metastatic lesion of a desmoplastic small round cell tumor (DSRCT) of the abdomen. The diagnosis of an intra-abdominal malignancy, most commonly a DSRCT, should be considered in the presence of an umbilical mass in a child.
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Doros
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D014472:Umbilicus / Q000473:pathology* / Q000601:surgery