IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis.
Inflammatory/immune reactions against muscle cells are responsible for the damage in idiopathic inflammatory myopathies. We investigated the role of IL-6, a cytokine known to contribute to local leukocyte accumulation, in a model of myosin-induced experimental myositis. After injection of rabbit myosin in CFA/pertussis toxin, normal mice develop clinically evident muscle deficit and damage, as demonstrated by myofiber necrosis and leukocyte infiltration, while IL-6-deficient mice have no clinical or histological signs of muscle damage. This study evidences that selective deficiency of IL-6 directly or indirectly hinders the local inflammatory response and its harmful effects in this model of muscle damage.
Scuderi
Flavia
F
Institute of General Pathology, Catholic University, Largo F. Vito 1, 00168 Rome, Italy.
Mannella
Francesca
F
Marino
Mariapaola
M
Provenzano
Carlo
C
Bartoccioni
Emanuela
E
D000818:Animals; D000917:Antibody Formation; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000517:prevention & control*; D015850:Interleukin-6 / Q000172:deficiency / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D009218:Myosins / Q000276:immunology*; D009220:Myositis / Q000209:etiology / Q000517:prevention & control*
D015850:Interleukin-6; D009218:Myosins