title: Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.
abstract: To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We studied the morphology of arterioles and venules of the bulbar conjunctiva using photograph records. The setting up of continuous flow caused global vasoconstriction (significant in venules-P < 0.05). During the pumping in the pulsatile and percentage of pulsatile modes, no significant changes of microvessel morphology were observed. The findings described could point to some disturbances in the microcirculatory bed in conditions of continuous flow.
authors.affiliation: Clinic of Functional Diagnostics and Rehabilitation, St Anna Faculty Hospital and Masaryk University of Brno, Brno, Czech Republic. petr.dobsak@fnusa.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Dobsák
authors.forename: Marie
authors.initials: M
authors.lastname: Novakova
authors.forename: Atsushi
authors.initials: A
authors.lastname: Baba
authors.forename: Jaromir
authors.initials: J
authors.lastname: Vasku
authors.forename: Takashi
authors.initials: T
authors.lastname: Isoyama
authors.forename: Itsuro
authors.initials: I
authors.lastname: Saito
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Chinzei
authors.forename: Kou
authors.initials: K
authors.lastname: Imachi
mesh_terms: D000818:Animals; D003228:Conjunctiva / Q000098:blood supply; D004867:Equipment Design; D005260:Female; D006041:Goats; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008833:Microcirculation; D011673:Pulsatile Flow