Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography.
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
Brooksby
Ben
B
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA.
Pogue
Brian W
BW
Jiang
Shudong
S
Dehghani
Hamid
H
Srinivasan
Subhadra
S
Kogel
Christine
C
Tosteson
Tor D
TD
Weaver
John
J
Poplack
Steven P
SP
Paulsen
Keith D
KD
D000273:Adipose Tissue / Q000166:cytology*; D000368:Aged; D001940:Breast / Q000166:cytology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014054:Tomography / Q000379:methods*
D006454:Hemoglobins