title: Antiproliferative ent-Kauranoids from Isodon parvifolius.
abstract: Nine new 7alpha,20-epoxy- ENT-kaurane diterpenoids, parvifolines O - W (1 - 9), together with five known analogues, lasiocarpanin (10), rosthorin A (11), longikaurin E (12), adenolin D (13) and longikaurin B (14), were isolated from the leaves of Isodon parvifolius. Their structures were determined by means of spectroscopic analysis. Selected diterpenoids (1 - 10) were tested for their antiproliferative activity against A549, HT-29 and K562 cells. Compounds 3, 7, 8 and 10 showed moderate inhibitory activity against all three cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Xun
authors.initials: X
authors.lastname: Liao
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D037602:Isodon; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D010936:Plant Extracts