Power spectrum analysis and cardiovascular morbidity in anxiety disorders.
Spectral analysis of heart rate variability (HRV) and related measures has been shown to be a reliable noninvasive technique enabling quantitative assessment of cardiovascular autonomic regulatory responses to autonomic regulatory mechanisms; it provides a dynamic probe of sympathetic and parasympathetic tone, reflecting the interactions between the two. Over 20 studies reported abnormalities of HRV in anxiety, and patients with heart disease and anxiety are at increased risk for morbidity and mortality. Psychiatric drugs partly correct abnormalities of HRV and, recently, autonomic drugs (beta-blockers) have been studied in anxiety disorders. The authors call for further studies, especially in patients with co-existing anxiety disorders and heart disease, incorporating assessment of HRV.
Cohen
Hagit
H
Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 4600, Beer-Sheva, Israel. hagitc@bgumail.bgu.ac.il
Benjamin
Jonathan
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001008:Anxiety Disorders / Q000150:complications* / Q000503:physiopathology; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods / Q000639:trends; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists