title: Sequential observation of movement disorders and brain images in the case of central pontine myelinolysis and extrapontine myelinolysis.
abstract: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to rapid correction of hyponatremia and have been reported to show a variety of movement disorders. However, sequential observation of movement disorders as well as brain images has seldom been reported. We report a case of CPM and EPM presenting with various sequential changes in movement disorders including delayed choreic movement over 11 months; we present sequential brain magnetic resonance images showing increased T1 and decreased fat-suppression T1 signal intensity. We suggest that delayed low signal intensity, in the fat-suppression T1-weighted images, is a result of the destruction of myelin and by products. Damage to the myelin may cause various movement disorders in a delayed manner.
authors.affiliation: Movement Disorder Division, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jung Im
authors.initials: JI
authors.lastname: Seok
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Youn
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Chung
authors.forename: Won Yong
authors.initials: WY
authors.lastname: Lee
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D017590:Myelinolysis, Central Pontine / Q000000981:diagnostic imaging / Q000473:pathology*; D011149:Pons / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed