title: Comparison of gated blood pool SPECT and multi-detector row computed tomography for measurements of left ventricular volumes and ejection fraction in patients with atypical chest pain: validation with radionuclide ventriculography.
abstract: Gated blood pool SPECT (GBPS) is an alternative to planar radionuclide ventriculography (PRNV) and offers potential advantages. The aim of this study was to compare GBPS, multi-row detector spiral computed tomography (MDCT), and PRNV for the determination of left ventricular ejection fraction (LVEF) and left ventricular volumes (LV) in subjects with atypical chest pain.
  
  
  METHODS
  Twenty-three consecutive patients (14 men, 9 women; mean age 56.2 +/- 9.5 years) referred for MDCT for evaluation of atypical chest pain. All patients underwent PRNV, GBPS, and MDCT at the same day.
  
  
  RESULTS
  The mean LVEFs calculated with PRNA (57.3 +/- 8.6%), GBPS (55.2 +/- 6.6%), and MDCT (56 +/- 9.1%) were not statistically different (F value 0.3374, p = 0.715). Comparison of LVEFs from GBPS and MDCT yielded correlation coefficients of 0.5238 (p = 0.0178, 95% CI = 0.1057-0.7845). The correlation of LVEFs between GBPS and PRNV showed a correlation coefficient of 0.8073 (p < 0.0001, 95% CI = 0.5676-0.9209) and 0.6190 (p = 0.0036, 95% CI = 0.2431-0.8333) between MDCT and PRNV. The mean LV end-diastolic volume (EDV) calculated with GBPS (82.7 +/- 17.5 ml) was significantly lower than MDCT (106.8 +/- 18.5 ml) (p = 0.0001). The mean LV end-systolic volume (ESV) calculated with GBPS (37.2 +/- 9.6 ml) was also significantly lower than MDCT (48.1 +/- 15.8 ml) (p = 0.012). Comparison of EDV from GBPS and MDCT yielded a correlation coefficient of 0.5220 (p = 0.0182, 95% CI = 0.1033-0.7835). The correlation of ESV between GBPS and MDCT showed a correlation coefficient of 0.6642 (p = 0.0014, 95% CI = 0.3140-0.8553).
  
  
  CONCLUSIONS
  In conclusion, the LVEF, EDV, and ESV calculated by GBPS correlated significantly with those of obtained with 16-MDCT. In addition, there were no statistical differences of LVEF calculated from PRNV, GBPS, and MDCT. However, with regard to LV, EDV and ESV from GBPS revealed statistically significantly lower than those of MDCT. Also, these results should be addressed whether similar results could also be found in patients with cardiac diseases by the consequent larger population-based study.
authors.affiliation: Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: In-Ju
authors.initials: IJ
authors.lastname: Kim
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Choo
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lee
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: June Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Yong-Ki
authors.initials: YK
authors.lastname: Kim
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Hyun Jun
authors.initials: HJ
authors.lastname: Cho
mesh_terms: D000465:Algorithms; D002637:Chest Pain / Q000000981:diagnostic imaging*; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015635:Radionuclide Ventriculography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013670:Sodium Pertechnetate Tc 99m; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m