title: Temporal relationship between prostate brachytherapy and the diagnosis of colorectal cancer.
abstract: OBJECTIVE
  To identify the location of pretreatment and posttreatment colorectal malignancies and posttreatment colorectal polyps in patients with clinically localized prostate cancer managed with brachytherapy.
  
  
  METHODS
  From April 1995 through July 2004, 1,351 consecutive patients underwent brachytherapy for clinical stage T1b-T3a (American Joint Committee on Cancer, 2002) prostate cancer. Supplemental external beam radiotherapy (XRT) was administered to 699 patients. The median follow-up was 4.6 years. Operative and pathology reports were reviewed for all patients with pretreatment and posttreatment colorectal cancer and posttreatment colorectal polyps. Multiple parameters were evaluated for the development of colorectal cancer or colorectal polyps.
  
  
  RESULTS
  Colorectal cancer was diagnosed in 23 and 25 patients before and after prostate brachytherapy, respectively. No differences were identified in the distribution of colorectal cancers either before or after treatment (3 and 4 rectal cancers in the pre- and postbrachytherapy cohorts). Thirty-five of the 48 colorectal cancers (73%) were diagnosed within 5 years of brachytherapy with a peak incidence 1 year after brachytherapy. One hundred ninety-two colorectal polyps were diagnosed after brachytherapy, 160 (83%) occurred within 4 years of brachytherapy, and only 27 (14%) were located in the rectum. In multivariate Cox regression analysis, prostate D(90) (minimum percentage of the dose covering 90% of the target volume) predicted for posttreatment colorectal cancer. Rectal polyps were most closely related to patient age and percent positive biopsies, whereas sigmoid/colon polyps were best predicted by patient age, planning volume, and supplemental XRT.
  
  
  CONCLUSIONS
  Colorectal cancer was diagnosed with equal frequency before and after brachytherapy with comparable geographic distributions. In addition, the vast majority of postbrachytherapy colorectal polyps were located beyond the confines of the rectum.
authors.affiliation: Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, WV 26003, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Gutman
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Merrick
authors.forename: Wayne M
authors.initials: WM
authors.lastname: Butler
authors.forename: Kent E
authors.initials: KE
authors.lastname: Wallner
authors.forename: Zachariah A
authors.initials: ZA
authors.lastname: Allen
authors.forename: Robert W
authors.initials: RW
authors.lastname: Galbreath
authors.forename: Edward
authors.initials: E
authors.lastname: Adamovich
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001918:Brachytherapy; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D012002:Rectal Diseases / Q000175:diagnosis*; D013997:Time Factors