title: A molecular epidemiological study of rabies in Cuba.
abstract: To investigate the emergence and current situation of terrestrial rabies in Cuba, a collection of rabies virus specimens was employed for genetic characterization. These data supported the monophyletic nature of all terrestrial rabies viruses presently circulating in Cuba but additionally delineated several distinct variants exhibiting limited spatial distribution which may reflect the history of rabies spread on the island. The strain of rabies currently circulating in Cuba, which emerged on the island in the early 20th century, has very close evolutionary ties to the Mexican dog type and is a member of the cosmopolitan lineage widely distributed during the colonial period. The Cuban rabies viruses, which circulate predominantly within the mongoose population, are phylogenetically distant from viruses circulating in mongooses in other parts of the world. These studies illustrate, at a global level, the adaptation of multiple strains of rabies to mongoose species which should be regarded as important wildlife hosts for rabies re-emergence. Given the recent emergence of human cases due to bat contact in Cuba, this study also included a single insectivorous bat specimen which was found to most closely resemble the rabies viruses known to circulate in Mexican vampire bats.
authors.affiliation: Rabies Center of Expertise, Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, Canada. nadindaviss@inspection.gc.ca
authors.forename: S A
authors.initials: SA
authors.lastname: Nadin-Davis
authors.forename: G
authors.initials: G
authors.lastname: Torres
authors.forename: M De Los Angeles
authors.initials: Mde L
authors.lastname: Ribas
authors.forename: M
authors.initials: M
authors.lastname: Guzman
authors.forename: R Cruz
authors.initials: RC
authors.lastname: De La Paz
authors.forename: M
authors.initials: M
authors.lastname: Morales
authors.forename: A I
authors.initials: AI
authors.lastname: Wandeler
mesh_terms: D000818:Animals; D002685:Chiroptera / Q000821:virology*; D003462:Cuba / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D019590:Nucleocapsid Proteins / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011818:Rabies / Q000453:epidemiology* / Q000662:veterinary / Q000821:virology*; D011820:Rabies virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D015047:Zoonoses / Q000821:virology
chemical_list: D019590:Nucleocapsid Proteins; D012367:RNA, Viral