[The peculiarities of long-term amphetamine action on some brain enzyme systems].
The enzyme activity of serotonin and dopamine synthesis--tryptophan hydroxylase and tyrosine hydroxylase respectively--as well as content of dihydroxyphenylalanine (DOPA) in the brain structures of Wistar and August rat strains were studied in normal conditions and during long-term amphetamine administration (21 day) in dosage of 1.0 mg/kg. Between-strain differences were observed both in normal conditions and during amphetamine using. Inhibition of tyrosine hydroxylase activity, decrease of DOPA and activation of tryptophan hydroxylase activity in the brain structures were found in August rats under amphetamine action. On the contrary, inhibition of tryptophan hydroxylase activity, activation of tyrosine hydroxylase activity and increase of DOPA were revealed in Wistar rats. A relationship between neuronmediator systems metabolism in the brain and peculiarities of behavior and emotional reactivity of the animals during pathological influence was demonstrated.
Dovedova
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EL
Khrustalev
D A
DA
Mel'nikova
I E
IE
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology*; D004298:Dopamine / Q000096:biosynthesis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012701:Serotonin / Q000096:biosynthesis; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors; D014365:Tryptophan Hydroxylase / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D013566:Sympathomimetics; D012701:Serotonin; D000661:Amphetamine; D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D004298:Dopamine