Bacterial interference of penicillin-sensitive and -resistant Streptococcus pneumoniae by Streptococcus oralis in an adenoid organ culture: implications for the treatment of recurrent upper respiratory tract infections in children and adults.
OBJECTIVE
The role of the viridans group of streptococci (Streptococcus oralis) in the prevention of colonization with Streptococcus pneumoniae was investigated in an adenoid organ culture system.


METHODS
The adenoids from 10 patients who were undergoing adenoidectomy for either hypertrophy or recurrent otitis media were used.


RESULTS
Streptococcus oralis Parker and S. oralis Booth (two organisms isolated from the nasopharynges of patients undergoing adenoidectomy only and patients undergoing adenoidectomy and bilateral tympanostomy with tubes, respectively) uniformly inhibited both penicillin-sensitive and penicillin-resistant S. pneumoniae. Although both strains of S. oralis inhibited the growth of both S. pneumoniae strains, strain Parker provided more complete inhibition than did strain Booth.


CONCLUSIONS
The results indicate that some strains of S. oralis may inhibit the growth of the most serious pathogens in the nasopharynx. It is therefore possible that colonization of inhibitory strains of viridans streptococci may be used in the nasopharynx as a relatively safe and inexpensive approach to prevention of recurrent otitis media in some children and of recurrent suppurative sinusitis in both children and adults.
Bernstein
Joel M
JM
Department of Otolaryngology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, USA.
Haase
Elaine
E
Hasse
Elaine
E
Scannapieco
Frank
F
Dryja
Diane
D
Wolf
Judy
J
Briles
David
D
King
Janice
J
Wilding
Gregory E
GE
D000234:Adenoids / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D000898:Antibiosis / Q000502:physiology*; D002648:Child; D006801:Humans; D009924:Organ Culture Techniques; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D019533:Streptococcus oralis / Q000187:drug effects / Q000254:growth & development*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000254:growth & development*
D010406:Penicillins