Cystatin C reference values and aging.
OBJECTIVE
The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.


METHODS
The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.


RESULTS
CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L).


CONCLUSIONS
The use of CysC reference values adjusted for age should be carefully taken into consideration.
Ognibene
Agostino
A
Central Laboratory of Clinical Biochemistry, Careggi Hospital, Viale Morgagni 85, 50139 Florence, Italy. ognibenea@ao-careggi.toscana.it
Mannucci
Edoardo
E
Caldini
Anna
A
Terreni
Alessandro
A
Brogi
Marco
M
Bardini
Gianluca
G
Sposato
Iolanda
I
Mosconi
Valentina
V
Salvadori
Benedetta
B
Rotella
Carlo Maria
CM
Messeri
Gianni
G
D000328:Adult; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins