[The expression of HIF-1alpha in scars and its relationship to apoptosis].
OBJECTIVE
To explore the mechanism of hypoxic environment lessening in the course of scar maturation.


METHODS
The expression of hypoxia inducible factor 1alpha (HIF-1alpha) and p53 in granulation of burn wound, burn scars of different stages, and normal skin was detected with immunohistochemical staining. The expressions were quantified by the weight method. The relationship between HIF-1alpha and p53 was investigated.


RESULTS
With the scar maturation, the expression of HIF-1alpha gradually decreased while the expression of p53 gradually increased within one year. There was a negative correlation between HIF-1alpha and p53 (P < 0.01).


CONCLUSIONS
p53 plays an important role in scar maturation. Associated with p53, HIF-1alpha may induce apoptosis, which decreases oxygen consumption and lightens hypoxia in the scar maturation.
Li
Gao-feng
GF
Department of Plastic and Cosmetic Surgery, Hunan Province People's Hospital, Changsha, China.
Tan
Jun
J
Zhong
Qian
Q
Luo
Cheng-qun
CQ
Liu
Xun-yang
XY
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D015687:Cell Hypoxia; D002648:Child; D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D055815:Young Adult
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D016159:Tumor Suppressor Protein p53