Decreasing invasive pneumococcal disease in the elderly: a state-level analysis.
Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.
McBean
A Marshall
AM
Division of Health Services Research and Policy, University of Minnesota School of Public Health, MMC 97 A369 Mayo Memorial Building, 420 Delaware St., S.E., Minneapolis, MN 55455, USA. mcbea002@umn.edu
Jung
Kyoungrae
K
Hebert
Paul L
PL
D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000627:therapeutic use; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D022401:Meningococcal Vaccines / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D012044:Regression Analysis; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data
C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D007252:Influenza Vaccines; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines