title: FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738. I. Taxonomy, fermentation, isolation and physico-chemical properties.
abstract: Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleophoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kanasaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Seiji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hori
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D005658:Fungi / Q000145:classification* / Q000378:metabolism; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; C511074:FR 209602; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic