title: [Correlation between the expression of HER-2/neu, nm23 protein and local invasion and lymph node metastasis of human LSCC].
abstract: OBJECTIVE
  To explore the relationship between the expressions of HER-2/neu, nm23 protein and local invasion and lymp node metastasis of LSCC.
  
  
  METHODS
  The expression of HER-2/neu, nm23 protein was detected by immunohistochemical technique in 56 patients with human LSCC.
  
  
  RESULTS
  The positive expression rate of HER-2/neu protein in LSCC was not correlated with histological grade (P > 0.05). There was a significant relationship between the expression of HER-2/neu and the clinical stages, lymph node metastasis (P < 0.05, P < 0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than those with lymph node metastasis (P < 0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of LSCC. Furthermore, the negative correlation was found between the positive expression of HER-2/neu protein and the positive expression of nm23 protein in the group with lymph node metastasis.
  
  
  CONCLUSIONS
  The abnormal expression of HER-2/neu, nm23 protein play an important role in development and lymph node metastasis of LSCC.
authors.affiliation: Department of Otorhinolaryngology, Linyi People's Hospital, Linyi, 276003, China. liqin8226@163.com
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Kong
authors.forename: Wei
authors.initials: W
authors.lastname: Ming
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Ma
authors.forename: Zhaoke
authors.initials: Z
authors.lastname: Yang
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Du
authors.forename: Daliang
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D009362:Neoplasm Metastasis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human; C517938:NME1 protein, human