title: HIF-1 and tumour radiosensitivity.
abstract: Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, MSRB, Research Drive, Durham, NC 27710, UK.
authors.forename: B J
authors.initials: BJ
authors.lastname: Moeller
authors.forename: M W
authors.initials: MW
authors.lastname: Dewhirst
mesh_terms: D015687:Cell Hypoxia / Q000528:radiation effects*; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance
chemical_list: D051793:Hypoxia-Inducible Factor 1