[Saliva: more than just a factor in oral health].
Several salivary proteins are involved in the antimicrobial defence within the oral cavity, and are able to eliminate or inhibit a great number of microorganisms that enter the body via the oral cavity. Thus changes in the composition of saliva may not only affect people's oral health, but also have consequences for their general health. Based on salivary proteins, antimicrobial peptides have been synthesized. Potentially, these could be used as a new class of antibiotics. The antimicrobial peptides are hardly cytotoxic to human cells and do not evoke any or only very little resistence in microorganisms.
van Nieuw Ameronpn
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Afdeling Tandheelkundige Basiswetenschappen, sectie Orale Biochemie van het Academisch Centrum Tandheelkunde Amsterdam. a.vannieuwamerongen@vumc.nl
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Vissink
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D000890:Anti-Infective Agents / Q000032:analysis* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000032:analysis*; D002327:Cariostatic Agents / Q000032:analysis; D003731:Dental Caries / Q000517:prevention & control; D006801:Humans; D009909:Oral Health; D012463:Saliva / Q000737:chemistry / Q000502:physiology*; D012471:Salivary Proteins and Peptides / Q000032:analysis*
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D002327:Cariostatic Agents; D012471:Salivary Proteins and Peptides