Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome.
Trivalent chromium (1000 microg), as chromium picolinate, given without change in diet or activity level, caused a 38% mean improvement in glucose disposal rate in five obese subjects with polycystic ovary syndrome who were tested with a euglycemic hyperinsulinemic clamp technique. This suggests that chromium picolinate, an over-the-counter dietary product, may be useful as an insulin sensitizer in the treatment of polycystic ovary syndrome.
Lydic
Michael L
ML
Department of Obstetrics, Gynecology, and Reproductive Medicine, Division of Reproductive Endocrinology, Stony Brook University Hospital, State University of New York-Stony Brook School of Medicine, 1794-8091, USA. mlydic@notes2.cc.sunysb.edu
McNurlan
Margaret
M
Bembo
Shirley
S
Mitchell
Lina
L
Komaroff
Eugene
E
Gelato
Marie
M
D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000517:prevention & control*; D007333:Insulin Resistance; D007502:Iron Chelating Agents / Q000008:administration & dosage; D009765:Obesity / Q000188:drug therapy*; D010848:Picolinic Acids / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
D007502:Iron Chelating Agents; D010848:Picolinic Acids; C030614:picolinic acid