Morphological regeneration and hepatic functional mass after right hemihepatectomy.
OBJECTIVE
Liver has a remarkable ability to regenerate after major resection. However, little is known about the process of morphological regeneration and hepatic functional recovery in human.


METHODS
Sixteen donors who underwent right hemihepatectomy were enrolled in this prospective clinical study. The preoperative liver volume and remnant liver volume on postoperative days 5, 12 and 28 were calculated from serial transverse computed tomography images. Liver function was evaluated by measuring the intrinsic clearance of antipyrine before and on postoperative days 5 and 12 days, as well as the biochemical and coagulation assay.


RESULTS
A smaller residual liver tended to regenerate faster in 28 days. Operative factors, including intraoperative blood loss, inflow occlusion time, liver transection time and duration of operation were not significantly correlated with postoperative liver regeneration. The intrinsic clearances of antipyrine on postoperative days 5 and 12 days were significantly reduced compared to the respective values before the operation (p < 0.001 and p < 0.05, respectively). On the contrary, the intrinsic clearance values per unit liver volume significantly increased on postoperative 12 days (p < 0.05).


CONCLUSIONS
The microsomal function of individual hepatocytes may be upregulated after right liver resection perhaps in order to compensate for the reduced functional mass of the liver.
Kobayashi
Takashi
T
Department of Surgery, Showa General Hospital, Hepato-Biliary-Pancreatic Surgery Division, Kodaira, Tokyo, Japan. takakobayashi-tky@umin.ac.jp
Imamura
Hiroshi
H
Aoki
Taku
T
Sugawara
Yasuhiko
Y
Kokudo
Norihiro
N
Makuuchi
Masatoshi
M
D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology; D008111:Liver Function Tests; D008115:Liver Regeneration; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size
D000983:Antipyrine