title: High dose of intravenously given glucocorticosteroids decrease IL-8 production by monocytes in multiple sclerosis patients treated during relapse.
abstract: The aim of our study was to determine whether high doses of intravenous methylprednisolone have significant impact on immune parameters during the multiple sclerosis (MS) exacerbations. Peripheral blood of 32 MS patients was evaluated, using two-color flow cytometry before glucocorticosteroids and after 7 days from starting therapy. Significant increase of B cells, decrease of NK cells and monocytes producing IL-8 were observed after treatment. IL-8 is one of the cytokines responsible for blood-brain-barrier disruption and migration of immune cells to the central nervous system; in this aspect, explaining glucocorticosteroid effects during MS exacerbations.
authors.affiliation: Institute of Psychiatry and Neurology, 2nd Department of Neurology, Sobieskiego 9, 02-957 Warsaw, Poland.
authors.forename: Dagmara M
authors.initials: DM
authors.lastname: Mirowska-Guzel
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kurowska
authors.forename: Janusz
authors.initials: J
authors.lastname: Skierski
authors.forename: Mirosława
authors.initials: M
authors.lastname: Koronkiewicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wicha
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Kruszewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Czlonkowski
authors.forename: Anna
authors.initials: A
authors.lastname: Czlonkowska
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000502:physiology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D008775:Methylprednisolone