Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.
Moss
Steven J
SJ
Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.
Carletti
Isabelle
I
Olano
Carlos
C
Sheridan
Rose M
RM
Ward
Michael
M
Math
Vidya
V
Nur-E-Alam
Mohammad
M
Braña
Alfredo F
AF
Zhang
Ming Qiang
MQ
Leadlay
Peter F
PF
Méndez
Carmen
C
Salas
José A
JA
Wilkinson
Barrie
B
D020533:Angiogenesis Inhibitors / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*; D013237:Stereoisomerism
D020533:Angiogenesis Inhibitors; D005233:Fatty Alcohols; C005066:borrelidin