title: Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease.
abstract: In the unilateral rat model of Parkinson's disease (PD), amphetamine induced rotation is widely used as an index of both lesion deficits and of graft-derived recovery. We have analysed the time course of the rotational response in lesioned rats, and in rats with lesions and dopamine grafts. In lesioned rats, the rotation exhibited a typical dose-dependent response, with low rates of rotation in the first 10 min after injection, rising gradually to a maximum after 20-30 min. Grafted rats exhibited a peak of rotation in the first 10 min after injection, which then fell to a minimum after 30 min. We demonstrate that the response seen in grafted rats is both drug and dose-dependent and show that the rotational profile results from interaction of the grafted and intact striata which exhibit differential temporal responses to the amphetamine.
authors.affiliation: Department of Biosciences, Cardiff University, UK. torresem@cf.ac.uk
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Torres
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Dunnett
mesh_terms: D000661:Amphetamine; D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D000697:Central Nervous System Stimulants; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D017072:Neostriatum / Q000502:physiology; D010300:Parkinson Disease / Q000473:pathology / Q000523:psychology* / Q000628:therapy*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D000661:Amphetamine; D004298:Dopamine