Generation of 4-hydroxy-2-nonenal modified proteins in testes predicts improvement in spermatogenesis after varicocelectomy.
Increasing evidence suggests that testes with varicocele are exposed to oxidative stress (OS) with deterioration in spermatogenesis; however, the relationship between testicular OS and outcome after varicocelectomy is poorly understood. Levels of testicular 4-hydroxy-2-nonenal modified proteins, an OS marker, were significantly higher in responders than in nonresponders, suggesting that varicocelectomy reduces OS in testis.
Shiraishi
Koji
K
Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan. koji-shiraishi@uiowa.edu
Naito
Katsusuke
K
D000328:Adult; D000447:Aldehydes / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011506:Proteins / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013081:Sperm Motility; D013091:Spermatogenesis; D013737:Testis / Q000378:metabolism*; D016896:Treatment Outcome; D014646:Varicocele / Q000150:complications / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000379:methods
D000447:Aldehydes; D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen; D011506:Proteins; C027576:4-hydroxy-2-nonenal