title: The effect of perospirone on auditory P300 in schizophrenia: a preliminary study.
abstract: The present study was performed to determine the effect of perospirone, a novel antipsychotic drug with D(2)/5-HT(2A) antagonist and partial 5-HT(1A) agonist properties, on auditory P300 in eight patients with chronic schizophrenia. Switching to an equivalent dose of perospirone from prior antipsychotic medication was associated with a significant improvement in the negative symptoms of the positive and negative syndrome scale (PANSS). The change in P300 amplitude following a switch to perospirone correlated significantly with the improvement of general psychopathology symptoms, as well as with the change in scores on items of delusions, hallucinatory behavior, emotional withdrawal, depression, poor attention, and disturbance of volition. These results suggest that clinical improvement in response to perospirone in some patients may, at least in part, be mediated through cognitive change indexed by P300 in chronic schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan. taraki-tky@umin.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology; D003627:Data Interpretation, Statistical; D004594:Electrophysiology; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D007211:Indoles; D054833:Isoindoles; D013844:Thiazoles; C065533:perospirone