[Neuronal death and growth factors: new therapeutic approaches in Parkinson's disease].
Neurodegenerative disorders represent a major and growing cause of morbidity and mortality in our populations, and a therapeutic challenge for the years to come. This paper reviews the mechanisms implicated in neuronal death, focusing on the model of Parkinson's disease. Available data are critically presented, and oriented in a therapeutic perspective. Neuroprotective strategies are mentioned, along with stem cell transplantation, growth factor production and gene therapy.
Wider
C
C
Service de neurologie, CHUV, 1011 Lausanne. christian.wider@chuv.ch
Burkhard
P R
PR
Sajadi
A
A
Vingerhoets
F J G
FJ
D000818:Animals; D016923:Cell Death; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000627:therapeutic use; D006801:Humans; D009474:Neurons / Q000166:cytology; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*
D051100:Glial Cell Line-Derived Neurotrophic Factor