Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice.
Effect of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a selective MT1/MT2 receptor agonist, on motor coordination was studied using rota-rod performance in mice. Ramelteon did not impair rota-rod performance at doses of 3, 10 and 30 mg/kg, p.o. Melatonin and N-acetyl-5-hydroxytryptamine (N-acetyl-5-HT), a ligand of MT3 biding site, also had no impairment on the performance, per se. However, in combination with a low dose of diazepam (3mg/kg, p.o.), treatment with melatonin and N-acetyl-5-HT exacerbated the impairment by diazepam. Ramelteon had no significant effect on the diazepam-induced impairment of motor coordination.
Miyamoto
Masaomi
M
Pharmacology Research Laboratories III, Takeda Pharmaceutical Company Limited, Osaka 532-8686, Japan. Miyamoto_Masaomi@takeda.co.jp
D000818:Animals; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D044122:Receptor, Melatonin, MT1 / Q000819:agonists*; D044123:Receptor, Melatonin, MT2 / Q000819:agonists*
D007192:Indenes; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; C495910:ramelteon