title: Analysis of location and pattern of target vessel failure in chronic total occlusions after stent implantation and its potential for the efficient use of drug-eluting stents.
abstract: OBJECTIVE
  The recanalization of chronic total occlusions (CTOs) is a complex procedure with high rates of target vessel failure (TVF), i.e., restenosis or reocclusion. Little is known about the localization of lesion recurrence, and whether extensive stenting should be performed. In this prospective analysis, the area at high risk for restenoses after recanalization of CTO was localized.
  
  
  METHODS
  Angiograms of 97 consecutive patients and control angiograms after a mean period of 5 +/- 1.3 months were analyzed for location and length of the CTO and the sites of recurrences.
  
  
  RESULTS
  In total, 158 stents were implanted (1.6 +/- 0.9 per lesion). Restenoses occurred in 39% and reocclusions in 17% of the patients. Patients with a TVF had a longer CTO than patients without TVF (17.9 +/- 10.2 vs 13.9 +/- 8.6 mm; P = 0.023). The TVF rate increased with the number of implanted stents. The stent diameter was smaller in lesions with subsequent reocclusions than in restenotic and nonrestenotic lesions (2.8 +/- 0.5 vs 3.0 +/- 0.4 and 3.2 +/- 0.4 mm resp.; P = 0.007). Analyzing the localization of the 38 restenoses, we only found 45% restricted to the area of the former CTO, while 82% were located in the area of the former CTO plus 10 mm in proximal and distal direction.
  
  
  CONCLUSIONS
  Stents should not only cover the site of the CTO, but should enclose the high-risk area of recurrence within 10 mm proximal and distal of the former CTO. This may guide the rational use of drug-eluting stents.
authors.affiliation: Department of Cardiology, Friedrich-Schiller University, Jena, Germany. stefan.betge@med.uni-jena.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Betge
authors.forename: Andreas
authors.initials: A
authors.lastname: Krack
authors.forename: Hans R
authors.initials: HR
authors.lastname: Figulla
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Werner
mesh_terms: D000368:Aged; D002908:Chronic Disease; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000503:physiopathology / Q000517:prevention & control*; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015607:Stents; D017211:Treatment Failure