Successful treatment of cytomegalovirus-associated haemophagocytic syndrome following paediatric orthotopic liver transplantation.
Haemophagocytic syndrome (HPS) following orthotopic liver transplantation is a rare event which is often fatal. We report here a case of HPS in association with cytomegalovirus (CMV) reactivation. The patient was treated with a combination of antiviral agents, immunomodulatory and supportive therapy which resulted in suppression of CMV infection and resolution of the haemophagocytosis.
Hardikar
Winita
W
Department of Gastroenterology, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria, Australia. winita.hardikar@rch.org.au
Pang
Ken
K
Al-Hebbi
Homoud
H
Curtis
Nigel
N
Couper
Richard
R
D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D016031:Liver Transplantation; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000628:therapy; D008297:Male; D010198:Pancytopenia / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D011183:Postoperative Complications; D016896:Treatment Outcome
D000998:Antiviral Agents