[The role of polypotent cells in development of pancreatic tumors].
280 epithelial tumors of the pancreas including 72 exocrine tumors (50 adenocarcinomas, 10 mucin-cystic, 6 intraductal, 6 serous cystic), 202 endocrine tumors and 6 undifferentiated neoplasms and surrounding parenchyma outside of the tumors were studied. Tumors arise against the background of pronounced proliferation of polypotent cells of the ducts. In case of tumors of ductal origin hyperplasia of ductal epithelium and acinar- ductal transformation of surrounding parenchyma are observed while in tumors with neuroendocrine differentiation there is mucous-papillary hyperplasia of ductal epithelium with proliferation in them of endocrine precursors, less frequently- acinar-endocrine transformation of surrounding parenchyma.
D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007633:Keratins / Q000096:biosynthesis*; D010183:Pancreatic Ducts / Q000378:metabolism* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D039904:Pluripotent Stem Cells / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D007633:Keratins