Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes.
The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(O iPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfully applied this methodology to the difluoromethylation of aldehydes using Me3SiCF2SePh, Me3SiCF2P(O)OEt2 and Me3SiCF2SPh.
Mizuta
Satoshi
S
Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
Shibata
Norio
N
Ogawa
Shinichi
S
Fujimoto
Hiroyuki
H
Nakamura
Shuichi
S
Toru
Takeshi
T