Automatic detection of spironolactone - related adverse drug events.
Due to increasing reports of spironolactone associated life-threatening hyperkalemia, we implemented a rule in our automated event detection system to monitor serum potassium results in patients receiving spironolactone. In 2004, 419 (10.49%) of 3995 admissions at 3 BJC HealthCare hospitals were identified as having hyperkalemia while on spironolactone. For a 9-month period in one facility, 33 of 52 automatically detected potential ADEs had been validated by pharmacists through manual chart review to have spironolactone as a contributing factor (PPV=63.5%).
Huang
Christine
C
BJC HealthCare, St. Louis, Missouri, USA.
Noirot
Laura A
LA
Reichley
Richard M
RM
Bouselli
Dennis A
DA
Dunagan
Wm Claiborne
WC
Bailey
Thomas C
TC
D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D004232:Diuretics / Q000009:adverse effects*; D006751:Hospital Information Systems; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced / Q000175:diagnosis*; D008491:Medical Informatics Applications; D008510:Medication Systems, Hospital; D013148:Spironolactone / Q000009:adverse effects*
D004232:Diuretics; D013148:Spironolactone