Why aging T cells fail: implications for vaccination.
The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly.
Haynes
Laura
L
Trudeau Institute, Inc., Saranac Lake, New York 12983.
Swain
Susan L
SL
Trudeau Institute, Inc., Saranac Lake, New York 12983. Electronic address: sswain@northnet.org.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000375:Aging / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination
D000276:Adjuvants, Immunologic