title: Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio.
abstract: OBJECTIVE
  To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls.
  
  
  METHODS
  32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length.
  
  
  RESULTS
  No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients.
  
  
  CONCLUSIONS
  Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, P.O. Box 104, H-1442 Budapest, Hungary. humanic@noi1.sote.hu
authors.forename: Erik E
authors.initials: EE
authors.lastname: Hauzman
authors.forename: Péter
authors.initials: P
authors.lastname: Fancsovits
authors.forename: Akos
authors.initials: A
authors.lastname: Murber
authors.forename: Thomas
authors.initials: T
authors.lastname: Rabe
authors.forename: Thomas
authors.initials: T
authors.lastname: Strowitzki
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Papp
authors.forename: János
authors.initials: J
authors.lastname: Urbancsek
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005498:Follicular Phase; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood; D013997:Time Factors
chemical_list: C422362:inhibin A; C422364:inhibin B; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone