Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa.
Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells.
Chin
Young-Won
YW
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Jones
William P
WP
Mi
Qiuwen
Q
Rachman
Ismail
I
Riswan
Soedarsono
S
Kardono
Leonardus B S
LB
Chai
Hee-Byung
HB
Farnsworth
Norman R
NR
Cordell
Geoffrey A
GA
Swanson
Steven M
SM
Cassady
John M
JM
Kinghorn
A Douglas
AD
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D018515:Plant Leaves / Q000737:chemistry*; D029648:Verbenaceae / Q000737:chemistry*
D045785:Diterpenes, Clerodane; C514657:premnone A; C514658:premnone B; C514659:premnone C