[A nimodipine interventional study of patients with mild cognitive impairment].
OBJECTIVE
To observe the effect of nimodipine on the cognition status and the changes of metabolites in brain tissue in the patients with mild cognitive impairment (MCI) in order to evaluate the significance of intervening MCI with medication.


METHODS
31 patients with MCI were selected 16 cases were in a treatment group taking nimodipine for 3 months besides taking basic internal medication and 15 cases in a control group taking only basic internal medication. Before and after treatment, multiple cognition tests were carried out in both groups and magnetic resonance spectroscopy (MRS) in Hippocampus region was carried out in 5 patients of the treatment group.


RESULTS
Verbal instant recall scores, symbol digit modalities test (SDMT) scores and mini-mental state examination (MMSE) total scores in the treatment group were improved significantly after treatment as compared with those in the control group (P < 0.05).


CONCLUSIONS
Nimodipine can improve memory ability as well as attention ability of the patients with MCI to a certain extent and make the general cognition function improved.
Wang
Wei
W
Department of Neurology, South Building, PLA General Hospital, Beijing 100853, China. wangwei301@hotmail.com
Wang
Lu-ning
LN
Zhang
Xiao-hong
XH
Ma
Lin
L
Li
De-jun
DJ
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D009553:Nimodipine / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D009553:Nimodipine