Epstein-Barr virus and human immunodeficiency virus-negative oral plasmablastic lymphoma.
Plasmablastic lymphoma (PBL) is an unusual subtype of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphoma that was first described in the oral cavity. HIV-related lymphomas are frequently associated with Epstein-Barr virus (EBV). Recently, dual infection with EBV and human herpesvirus 8 (HHV8) has been demonstrated in PBL. So far, a few cases of PBL occurring in an HIV-negative patient have been documented and all of them were associated with immunosuppression status and/or EBV infection. Here we report a EBV and HHV8-negative oral PBL occurring in an immunocompetent HIV-negative male, which would be the first case.
Lee
Ok-Jun
OJ
Department of Pathology, Chungbuk National University College of Medicine, Cheongju-si, Korea.
Kim
Kyoung-Won
KW
Lee
Geon Kook
GK
D000368:Aged; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000097:blood / Q000473:pathology*; D018023:HIV Seronegativity; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000097:blood / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D011509:Proteoglycans / Q000032:analysis; D053667:Syndecans; D014746:Vimentin / Q000032:analysis
D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans; D014746:Vimentin