title: Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease.
abstract: Thrombocytopenia is one of the main clinical findings of dengue. In this work we examined the levels of thrombopoietin (TPO) and interleukin-11 (IL-11), two of the most potent regulators of platelet production, in serum from 28 patients with dengue fever (DF). Patients with DF had increased levels of TPO, compared with healthy individuals (p<0.005). Patients with dengue hemorrhagic fever (DHF, n=7), the more severe form of dengue, had higher TPO levels than patients with DF (p<0.001). Serum TPO levels and platelet counts were inversely correlated in both DF and DHF patients. IL-11 was detectable in neither DF nor DHF patients. Our results demonstrate that thrombocytopenia in dengue disease is associated with changes in the serum levels of TPO, but not IL-11, suggesting that this cytokine could be a potential early clinical marker of the severity of dengue disease.
authors.affiliation: Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, IVIC, Apartado 21827, Caracas 1020-A, Venezuela. jcardier@ivic.ve
authors.forename: Jose E
authors.initials: JE
authors.lastname: Cardier
authors.forename: Valeria
authors.initials: V
authors.lastname: Balogh
authors.forename: Carlos
authors.initials: C
authors.lastname: Perez-Silva
authors.forename: Egidio
authors.initials: E
authors.lastname: Romano
authors.forename: Betty
authors.initials: B
authors.lastname: Rivas
authors.forename: Norma
authors.initials: N
authors.lastname: Bosch
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003715:Dengue / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D017370:Interleukin-11 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019595:Severe Dengue / Q000097:blood / Q000276:immunology; D013921:Thrombocytopenia / Q000097:blood* / Q000276:immunology; D013926:Thrombopoietin / Q000097:blood* / Q000276:immunology
chemical_list: D017370:Interleukin-11; D013926:Thrombopoietin