Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.
Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3, 5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.
Fujimoto
Haruka
H
Institute of Molecular & Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan.
Noguchi
Tomomi
T
Kobayashi
Hisayoshi
H
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D051545:Cyclooxygenase 1 / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D013792:Thalidomide / Q000031:analogs & derivatives / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014471:Umbilical Veins / Q000473:pathology
D020533:Angiogenesis Inhibitors; D007155:Immunologic Factors; D013792:Thalidomide; D051545:Cyclooxygenase 1