Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults.
Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done to document the burden and distribution of these pathogens. We tested serum samples from 256 Cameroonian adults from nine rural villages for the presence of Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), and Tahyna (TAH) infection using standard plaque-reduction neutralization tests (PRNT). Of these samples, 12.5% were DEN-2 positive, 6.6% were WN positive, 26.9% were YF positive, 46.5% were CHIK seropositive, 47.7% were ONN positive, 7.8% were SIN positive, and 36.3% were TAH positive. DEN-2, YF, and CHIK seroprevalence rates were lower among individuals living in dwellings with grass or thatched roofs versus corrugated tin and in villages isolated from urban centers. Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations.
Kuniholm
Mark H
MH
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. mkunihol@jhsph.edu
Wolfe
Nathan D
ND
Huang
Claire Y-H
CY
Mpoudi-Ngole
E
E
Tamoufe
Ubald
U
LeBreton
Matthew
M
Burke
Donald S
DS
Gubler
Duane J
DJ
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001103:Arboviruses / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D002044:Bunyaviridae Infections / Q000453:epidemiology*; D002163:Cameroon / Q000453:epidemiology; D003710:Demography; D005260:Female; D018177:Flavivirus Infections / Q000453:epidemiology*; D005843:Geography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012307:Risk Factors; D012424:Rural Population; D016036:Seroepidemiologic Studies; D014036:Togaviridae Infections / Q000453:epidemiology*
D000914:Antibodies, Viral