title: Thoracic aorta evaluation in patients with Takayasu's arteritis by transesophageal echocardiography.
abstract: BACKGROUND
  There is no detailed description of thoracic aorta abnormalities assessed by transesophageal echocardiography (TEE) in patients with Takayasu's arteritis (TA). We aimed to evaluate these features in a series of patients in the chronic stage of TA.
  
  
  METHODS
  Fourteen patients (13 women, mean age 30 years) with inactive chronic TA were studied by TEE, and compared with 14 matched patients without aortic disease defined by TEE, who served as control subjects. In each segment of the thoracic aorta (ascending, arch, proximal, and distal descending aorta), we analyzed: (1) wall thickness; (2) diastolic diameters; and (3) systolic expansion index as a percentage of aortic expansibility.
  
  
  RESULTS
  Increased circumferential wall thickness (71% of 55 aortic segments studied) and dilated segments (37%) were observed in patients with TA, with significant higher values than control subjects (P < .05). A global impairment of the elastic properties of the thoracic aorta of patients with TA was noted in 85% of the analyzed segments, expressed by a significant reduction of the systolic expansion index (3.9 +/- 3.8%) as compared with control subjects (14 +/- 5.7%; P < .005).
  
  
  CONCLUSIONS
  TA as assessed by TEE is characterized by a remodeling process of the thoracic aorta with a marked and global decrease of aortic distensibility and concentric wall thickening. These features may be useful for noninvasive diagnosis of the chronic stage of TA by TEE.
authors.affiliation: Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil. edgarlfilho@yahoo.com.br
authors.forename: Edgar
authors.initials: E
authors.lastname: Bezerra Lira-Filho
authors.forename: Orlando
authors.initials: O
authors.lastname: Campos
authors.forename: Jose
authors.initials: J
authors.lastname: Lazaro Andrade
authors.forename: Cláudio
authors.initials: C
authors.lastname: Henrique Fischer
authors.forename: Colandy
authors.initials: C
authors.lastname: Godoy Nunes
authors.forename: Andréa
authors.initials: A
authors.lastname: Cavalcanti Lins
authors.forename: Francisca
authors.initials: F
authors.lastname: Hata
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D002908:Chronic Disease; D017548:Echocardiography, Transesophageal / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D013625:Takayasu Arteritis / Q000000981:diagnostic imaging*