title: [High-dose chemotherapy with peripheral blood stem cell auto transplantation for an intractable case of mediastinal seminoma].
abstract: HDC with PBSCT is effective for some intractable cases with malignant neoplasma. We encountered an intractable case of mediastinal seminoma treated by HDC with PBSCT. The patient was a 25-year-old man with mediastinal seminoma. He had undergone chemo-radiotherapy several times and salvage surgery for the mediastinal tumor and chest wall recurrence since September 2001. He was referred to our clinic for management of recurrent seminoma in the chest wall in January 2004. In our clinic, chemo-radiotherapy consisting of cisplatin and etoposide was performed. The tumor size decreased transiently, but re-growth was observed 2 months after chemo-radiotherapy. We then performed HDC with PBSCT twice without any lethal complication. Now, the patient is well and disease-free 1 year after HDC with PBSCT.
authors.affiliation: Dept. of Thoracic Surgery, Oita University Faculty of Medicine.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Miyawaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Imakire
authors.forename: Yozo
authors.initials: Y
authors.lastname: Kawano
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Kawahara
authors.forename: Junji
authors.initials: J
authors.lastname: Ikewaki
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction; D018239:Seminoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D005047:Etoposide; D002945:Cisplatin