title: [Sentinel lymph node biopsy in oral and oropharyngeal carcinomas].
abstract: BACKGROUND
  The aim of our study was to assess feasibility and accuracy of sentinel lymph node biopsy in patients with head and neck squamous cell carcinoma with clinically N0 neck.
  
  
  RESULTS
  The sentinel lymph node was localised preoperatively by lymphoscintigraphy and intraoperatively by hand-held gamma probe after peritumoral injection of a Tc99m-labeled colloidal human serum albumin. The histology of the sentinel lymph node was compared with the histology of the nodes of the elective neck dissection performed in all patients. 27 patients with oral and oropharyngeal carcinomas accessible to injection in local anaesthesia were enrolled into a prospective trial between July 1993 and December 2005. The sentinel lymph node was localised by preoperative lymphoscintigraphy in 26 of 27 patients. Sentinel lymph node was identified perioperatively by hand-held gamma probe in all 28 necks of 27 patients. Occult metastases were found in 4 sentinel lymph nodes in 4 cases. In one case (3.6 %) the result of sentinel lymph node biopsy was false negative. The sentinel lymph node biopsy correctly predicted the positivity and negativity of the neck in 27 of 28 cases (96.4 %).
  
  
  CONCLUSIONS
  Sentinel lymph node biopsy in patients with oral and oropharyngeal carcinomas is feasible and seems to accurately predict the status of the regional lymph nodes.
authors.affiliation: Klinika ORL a chirurgie hlavy a krku 1 LF UK a FNM, Praha. lubor.mrzena@fnmotol.cz
authors.forename: L
authors.initials: L
authors.lastname: Mrzena
authors.forename: J
authors.initials: J
authors.lastname: Betka
authors.forename: I
authors.initials: I
authors.lastname: Stárek
authors.forename: K
authors.initials: K
authors.lastname: Táborská
authors.forename: D
authors.initials: D
authors.lastname: Kodetová
authors.forename: H
authors.initials: H
authors.lastname: Krízová
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D037981:Neck Dissection; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin