The effects of deoxycorticosterone-induced sodium appetite on hedonic behaviors in the rat.
The authors tested the hypothesis that chronic treatment with a dose of deoxycorticosterone acetate (DOCA) known to elicit a robust sodium appetite can negatively affect the hedonic state of rats. Daily treatment with DOCA with no opportunity to ingest saline produced a rightward shift in the midpoint (effective current 50) of lateral hypothalamic self-stimulation (LHSS) current-response functions and reduced intakes of a palatable sucrose solution. Providing rats with 0.3 M saline during DOCA treatment prevented the rightward shift in LHSS response functions and the decrease in sucrose intake. The authors concluded that a chronic sodium appetite, with no opportunity to attenuate the appetite, can elicit a reduced responsiveness to reward.
Morris
Michael J
MJ
Department of Psychology, Pharmacology, and Exercise Science, and Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USA.
Na
Elisa S
ES
Grippo
Angela J
AJ
Johnson
Alan Kim
AK
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001703:Biophysics; D003216:Conditioning, Operant / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D008297:Male; D008901:Mineralocorticoids / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D012964:Sodium; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013997:Time Factors
D008901:Mineralocorticoids; D013549:Sweetening Agents; D003900:Desoxycorticosterone; D013395:Sucrose; D012964:Sodium