The aminergic control of cockroach salivary glands.
The acinar salivary glands of cockroaches receive a dual innervation from the subesophageal ganglion and the stomatogastric nervous system. Acinar cells are surrounded by a plexus of dopaminergic and serotonergic varicose fibers. In addition, serotonergic terminals lie deep in the extracellular spaces between acinar cells. Excitation-secretion coupling in cockroach salivary glands is stimulated by both dopamine and serotonin. These monoamines cause increases in the intracellular concentrations of cAMP and Ca(2+). Stimulation of the glands by serotonin results in the production of a protein-rich saliva, whereas stimulation by dopamine results in saliva that is protein-free. Thus, two elementary secretory processes, namely electrolyte/water secretion and protein secretion, are triggered by different aminergic transmitters. Because of its simplicity and experimental accessibility, cockroach salivary glands have been used extensively as a model system to study the cellular actions of biogenic amines and to examine the pharmacological properties of biogenic amine receptors. In this review, we summarize current knowledge concerning the aminergic control of cockroach salivary glands and discuss our efforts to characterize Periplaneta biogenic amine receptors molecularly.
Walz
Bernd
B
Department of Animal Physiology, Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.
Baumann
Otto
O
Krach
Christian
C
Baumann
Arnd
A
Blenau
Wolfgang
W
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism / Q000494:pharmacology*; D003058:Cockroaches / Q000033:anatomy & histology / Q000502:physiology*; D017982:Receptors, Biogenic Amine / Q000737:chemistry / Q000235:genetics; D018035:Receptors, Odorant / Q000235:genetics / Q000378:metabolism; D012463:Saliva / Q000378:metabolism / Q000502:physiology; D012469:Salivary Glands / Q000033:anatomy & histology / Q000187:drug effects / Q000294:innervation / Q000502:physiology
D001679:Biogenic Amines; D017982:Receptors, Biogenic Amine; D018035:Receptors, Odorant