Regulation and clinical significance of urokinase-receptor (u-PAR), an invasion-related molecule.
This review focuses on the urokinase-receptor (u-PAR), one of the critical molecules mediating tumor-associated proteolysis, invasion, and metastasis, amongst other phenomena associated with tumor progression. Especially, the article gives an overview on the molecular regulation of u-PAR, and its potential clinical and therapeutic relevance in gastrointestinal cancers.
Allgayer
H
H
Department of Experimental Surgery and Molecular Oncology, Klinikum Mannheim, and Joint Unit Molecular Oncology of Solid Tumors-DKFZ (German Cancer Research Center) Heidelberg, Klinikum Mannheim, Mannheim. heike.allgayer@chir.ma.uni-heidelberg.de
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D005786:Gene Expression Regulation; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator
D014408:Biomarkers, Tumor; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator