title: Cell wall assembly in Saccharomyces cerevisiae.
abstract: An extracellular matrix composed of a layered meshwork of beta-glucans, chitin, and mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle determines cellular morphology and plays a critical role in maintaining cell integrity during cell growth and division, under stress conditions, upon cell fusion in mating, and in the durable ascospore cell wall. Here we assess recent progress in understanding the molecular biology and biochemistry of cell wall synthesis and its remodeling in S. cerevisiae. We then review the regulatory dynamics of cell wall assembly, an area where functional genomics offers new insights into the integration of cell wall growth and morphogenesis with a polarized secretory system that is under cell cycle and cell type program controls.
authors.affiliation: Department of Biology, McGill University, Montreal, PQ H3A 1B1, Canada.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lesage
authors.forename: Howard
authors.initials: H
authors.lastname: Bussey
mesh_terms: D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins