title: Suppression of human brain tumor with interference RNA specific for tenascin-C.
abstract: Glioblastoma multiforme (GBM) accounts for approximately 12-15% of intracranial neoplasms. The GBM remains refractory to therapy because of tumor heterogeneity, local invasion, and non-uniform vascular permeability to drugs. Patients with GBM have the median survival of approximately 8-10 months, and for those cases where tumor recurs, the average time of tumor progression after therapy is only eight weeks. A combination of different treatment modes as surgery and chemo- or/and radiotherapy extend survival only for a short time, if any. Recently, tenascin-C (TN-C) as a dominant epitope in glioblastoma has been discovered. It is transiently expressed during organogenesis, absent or much reduced in most fully developed organs, but reappears under pathological conditions such as infection, inflammation, or tumorigenesis. It was found that the intensity of TN-C staining correlates with the tumor grade and that the strongest staining indicates poor prognosis.
authors.affiliation: Department of Neurosurgery and Neurotraumatology, University of Medical Sciences, Poznan, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Zukiel
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Nowak
authors.forename: Eliza
authors.initials: E
authors.lastname: Wyszko
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rolle
authors.forename: Iwona
authors.initials: I
authors.lastname: Gawronska
authors.forename: Miroslawa Z
authors.initials: MZ
authors.lastname: Barciszewska
authors.forename: Jan
authors.initials: J
authors.lastname: Barciszewski
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D034741:RNA, Small Interfering / Q000494:pharmacology*; D011859:Radiography; D019063:Tenascin / Q000235:genetics*
chemical_list: D034741:RNA, Small Interfering; D019063:Tenascin