title: Functional magnetic resonance imaging for defining the biological target volume.
abstract: Morphology as demonstrated by CT is the basis for radiotherapy planning. Intensity-modulated and adaptive radiotherapy techniques would greatly benefit from additional functional information allowing for definition of the biological target volume. MRI techniques include several which can characterize and quantify different tissue properties and their tumour-related changes. Results of perfusion MRI represent microvascular density and permeability; MR spectroscopy depicts particular metabolites; diffusion weighted imaging shows tissue at risk and tumour cellularity; while dynamic 3D acquisition (4D MRI) shows organ motion and the mobility of tumours within them.
authors.affiliation: Department of Radiology, Innovative Cancer Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany. hu.kauczor@dkfz.de
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Christian
authors.initials: C
authors.lastname: Zechmann
authors.forename: Bram
authors.initials: B
authors.lastname: Stieltjes
authors.forename: Marc-Andre
authors.initials: MA
authors.lastname: Weber
mesh_terms: D001369:Axons / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009038:Motion; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D009389:Neovascularization, Pathologic / Q000473:pathology; D009929:Organ Size; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D047368:Tumor Burden