title: [Analysis of clinical and pathological features of secretory meningiomas].
abstract: OBJECTIVE
  To investigate the clinicopathologic and immunohistochemical features of secretory meningiomas.
  
  
  METHODS
  Nine secretory meningiomas were examined. From each specimen, sections were cut and stained with hematoxylin-eosin, periodic acid-Schiff (PAS) stain, and periodic acid-Schiff stain with diatase(PAS-D ). Immunohistochemical markers including oestrogen receptor (ER), progesterone receptor (PR), carcinoembryonic antigen (CEA), cytokeratin (CK), epithelial membrane antigen (EMA), and MIB-1 were detected with streptavidin peroxidase (SP) immunohistochemical staining methods. One case was observed by electron microscopy (EM).
  
  
  RESULTS
  The 9 secretory meningiomas were located at sphenoid ridge, left parietal lobe or frontal lobe. Severe peritumoral edema was observed in 5 cases. Seven cases were followed up for 6 to 88 months; none of them showed evidence of recurrence. Histologically, the conspicuous feature was the eosinophilic inclusions. The finding of pericytic proliferation on examination was helpful to making a diagnosis. In all 9 cases, the tumor cells were positive for PR, but in 6 cases the inclusions were negative. ER was negative in 8 cases. CEA,CK, EMA expressed in the inclusions and the surrounding cells in 7 cases. In 1 case the positive rate for MIB-1 was 5%, but in the other 8 cases the positive rates were not more than 2%. The intercellular lumens and intracellular mucosa were observed under EM.
  
  
  CONCLUSIONS
  Secretory meningioma is a rare subtype of meningioma that shows glandular epithelium differentiation. It is a meningioma of the low-risk type in terms of incidence, recurrence and prognosis.
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xin-jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Lang
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.forename: Hui-jiao
authors.initials: HJ
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Bu
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D002272:Carcinoembryonic Antigen; D011980:Receptors, Progesterone; D007633:Keratins