Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579.
[structure: see text] Hirsutellone F (7), a novel alkaloid dimer, was isolated together with known monomers, hirsutellones A (1), B (2), and C (3), from the seed fungus Trichoderma sp. BCC 7579. The structure of 7 was elucidated by spectroscopic analysis. Studies on biomimetic chemistry, using the dimer 7, suggested that compound 8 (17,1'-dehydrohirsutellone B) should be the precursor for all hirsutellones.
Isaka
Masahiko
M
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani. isaka@biotec.or.th
Prathumpai
Wai
W
Wongsa
Patcharaporn
P
Tanticharoen
Morakot
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry; D014242:Trichoderma / Q000737:chemistry*
D000470:Alkaloids; D000962:Antimalarials; D000995:Antitubercular Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C518448:hirsutellone F