Function of hemopoietic stem cells under conditions of cytostatic myelosuppression and treatment with hemostimilators.
We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects of hemostimulators on stem cells are determined by different proportions between proliferation and differentiation processes.
Zhdanov
V V
VV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Gur'yantseva
L A
LA
Udut
E V
EV
Khrichkova
T Yu
TY
Simanina
E V
EV
Gol'dberg
V E
VE
D000818:Animals; D049109:Cell Proliferation; D003520:Cyclophosphamide / Q000494:pharmacology; D020723:Glucuronic Acid / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006413:Hematopoietic System / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020723:Glucuronic Acid; D003520:Cyclophosphamide