title: A dose-response model for the conventional phototherapy of the newborn.
abstract: Jaundice of the newborn is a common problem as a consequence of the rapid increment of blood bilirubin in the first days of live. In most cases, it is considered a physiological transient situation, but unmanaged hyperbilirubinemia can lead to death or serious injuries for the survivors. For decades, phototherapy has been used as the main method for prevention and treatment of hyperbilirubinaemia of the newborn. This work aims at finding a predictive model for the decrement of blood bilirubin for patients submitted to conventional phototherapy. Data from the phototherapy of 90 term newborns were collected and used in a multiple regression method. A rigorous statistical analysis was done in order to guarantee a correct and valid model. The obtained model was able to explain 78% of the variation of the dependent variable. We show that it is possible to predict the total serum bilirubin of the patient under conventional phototherapy by knowing its birth weight, bilirubin level at the beginning of treatment and the radiant energy density (dose). Besides, it is possible to infer the time necessary for a given decrement of bilirubin, under approximately constant irradiance. Statistical analysis of the obtained model shows that it is valid for several ranges of birth weight, initial bilirubin level, and radiant energy density. It is expected that the proposed model can be useful in the clinical management of hyperbilirubinemia of the newborn.
authors.affiliation: Hospital Universitário Universidade Estadual do Oeste do Paraná - UNIOESTE, R. da Bandeira, 668, 85812-270, Cascavel, Brazil.
authors.forename: Nelson Ossamu
authors.initials: NO
authors.lastname: Osaku
authors.forename: Heitor Silvério
authors.initials: HS
authors.lastname: Lopes
mesh_terms: D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007565:Jaundice / Q000175:diagnosis* / Q000628:therapy*; D008027:Light; D008297:Male; D008954:Models, Biological; D010789:Phototherapy / Q000379:methods*; D011829:Radiation Dosage; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome