title: Seizures in children with low-grade tumors: outcome after tumor resection and risk factors for uncontrolled seizures.
abstract: OBJECTIVE
  The goals of this study were to define the incidence of seizures in children with low-grade tumors, study seizure outcome after lesionectomy in these children, and identify risk factors for poor seizure outcome.
  
  
  METHODS
  The authors performed a retrospective chart review of children who harbored low-grade brain tumors, experienced seizures, and were treated in a single institution. Statistical analyses included step-wise as well as single-variable binary logistic regression analyses. Fifty-five children (20%) with seizures were identified in a cohort of 280 children with low-grade tumors. Of these 55 children, 35 harbored cortical cerebral tumors and 20 had noncortical lesions, including six whose tumors were in the posterior fossa. Seizures were defined as controlled if there was no seizure in the 12 months preceding the last clinic visit. All cortical tumors were treated by lesionectomy as an initial procedure. Of the 27 children with cortical tumors whose seizures began before tumor diagnosis, 23 had complete resection and 52% of these 23 experienced no further seizures after surgery. Seizures are presently controlled in 84% of the total 55 patients at a median follow-up time of 4.5 years after the first seizure (range 1-17.4 years). Only two variables, a pericavity hyperintense signal on T2-weighted magnetic resonance (MR) images and at least 10 seizures prior to therapy for seizures, were associated with uncontrolled seizures.
  
  
  CONCLUSIONS
  Lesionectomy may be appropriate in children with low-grade brain tumors. A large number of seizures before therapy and a hyperintense area around the tumor cavity on postresection MR images are associated with uncontrolled seizures. Medical therapy and tumor resection will control seizures in the majority of children with low-grade tumors.
authors.affiliation: Departments of Radiological Sciences, Biostatistics, and Neuro-surgical Service, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. raja.khan@stjude.org
authors.forename: Raja B
authors.initials: RB
authors.lastname: Khan
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Boop
authors.forename: Arzu
authors.initials: A
authors.lastname: Onar
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sanford
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000473:pathology / Q000601:surgery*; D020288:Papilloma, Choroid Plexus / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome