Customizing a commercial rule base for detecting drug-drug interactions.
We developed and implemented an adverse drug event system (PharmADE) that detects potentially dangerous drug combinations using a commercial rule base. While commercial rule bases can be useful for rapid deployment of a safety net to screen for drug-drug interactions, they sometimes do not provide the desired rule sensitivity. We implemented methods for enhancing commercial drug-drug interaction rules while preserving the original rule base architecture for easy and low cost maintenance.
Resetar
Ervina
E
Washington University School of Medicine, Department of Internal Medicine, St. Louis, MO, USA.
Reichley
Richard M
RM
Noirot
Laura A
LA
Dunagan
Wm Claiborne
WC
Bailey
Thomas C
TC
D016907:Adverse Drug Reaction Reporting Systems; D004347:Drug Interactions; D004360:Drug Therapy, Computer-Assisted; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008508:Medication Errors / Q000517:prevention & control; D008510:Medication Systems, Hospital