title: Does subthalamic nucleus deep brain stimulation really improve quality of life in Parkinson's disease?
abstract: We investigated the impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on quality of life (QOL) in patients with advanced Parkinson's disease, as self-assessed before and after surgery by completing the Parkinson's Disease Questionnaire (PDQ39). In addition to this prospective evaluation, we asked patients postoperatively to evaluate their preoperative QOL. In the prospective assessment, results showed that patients perceived a general improvement of QOL after the STN DBS. However, when evaluated retrospectively, they tended to overestimate their preoperative functioning, therefore obscuring the improvement found prospectively. This observation highlights the impact of the method used on obtained results when assessing the effects of STN DBS.
authors.affiliation: Vaud-Geneva Deep Brain Stimulation Program for Movement Disorders, CHUV, Lausanne, Switzerland.
authors.forename: Aline
authors.initials: A
authors.lastname: Gronchi-Perrin
authors.forename: Sarah
authors.initials: S
authors.lastname: Viollier
authors.forename: Joseph
authors.initials: J
authors.lastname: Ghika
authors.forename: Pierre
authors.initials: P
authors.lastname: Combremont
authors.forename: Jean-Guy
authors.initials: JG
authors.lastname: Villemure
authors.forename: Julien
authors.initials: J
authors.lastname: Bogousslavsky
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Burkhard
authors.forename: François
authors.initials: F
authors.lastname: Vingerhoets
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D046690:Deep Brain Stimulation / Q000523:psychology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa