[A case of pneumonitis suspected to be induced by Oseltamivir].
A 33-year-old man had a high fever and was given Cefcapene and Oseltamivir without a definite diagnosis of influenza. Three days later an abnormal chest shadow was pointed out. Chest CT revealed ground-glass opacities and air-space consolidation in bilateral lung fields. Although he was given antibiotics, lung infiltrates increased and his symptoms worsened. Therefore, he was transferred to our hospital. Corticosteroid pulse-therapy resulted in prompt improvement of chest infiltrates and his symptoms. The drug-induced lymphocyte stimulating test results indicated 170% of oseltamivir and 150% of cefcapene. Considering the clinical course and laboratory data, this was probably drug-induced lung injury caused by oseltamivir.
Namba
Yoshinobu
Y
Department of Respiratory Medicine, National Hospital Organization National Toneyama Hospital.
Kitada
Seigo
S
Mori
Masahide
M
Iwasaki
Takeo
T
Motone
Masaharu
M
Niinaka
Manabu
M
Yoshimura
Kenji
K
Miki
Mari
M
Miki
Keisuke
K
Naka
Nobuyuki
N
Hiraga
Toru
T
Maekura
Ryoji
R
Ito
Masami
M
D000081:Acetamides / Q000009:adverse effects*; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D053139:Oseltamivir; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis
D000081:Acetamides; D000998:Antiviral Agents; D053139:Oseltamivir