title: In vitro leishmanicidal constituents of Millettia pendula.
abstract: The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.
authors.affiliation: Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Tsukuba, Ibaraki 305-0843, Japan.
authors.forename: Marii
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology; D016227:Benzoquinones / Q000494:pharmacology; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D033641:Millettia / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000977:Antiparasitic Agents; D016227:Benzoquinones; D007529:Isoflavones; D010936:Plant Extracts; C543885:millettilone A; C543886:millettilone B; C007768:formononetin; C088068:claussequinone