title: [Treatment of NASH: nutritional counseling and physical exercise].
abstract: Nonalcoholic fatty liver disease(NAFLD) is recognized as a cause of potentially progressive liver damage. NAFLD is often associated with metabolic syndrome that comprises central obesity, insulin resistance, and hyperlipidemia. Among these, severer forms with histopathological features of increasing ballooned hepatocytes and fibrosis are defined as nonalcoholic steatohepatitis (NASH). The natural history of NASH is only partly known, the disease is slowly progressive and therapeutic outcomes are difficult to define. Since central obesity and insulin resistance are most likely involved in the pathogenesis, justification of life style including physical exercise and nutritional counseling is essential for the treatment of NASH.
authors.affiliation: Division of Gastroenterology, Yokohama City University Graduate School of Medicine.
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Shiro
authors.initials: S
authors.lastname: Maeyama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D050260:Carbohydrate Metabolism; D004032:Diet; D015444:Exercise; D005234:Fatty Liver / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007333:Insulin Resistance; D008019:Life Style; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000150:complications