Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys.
ent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic methods, especially using 2D-NMR spectroscopic analyses. All ent-kaurenoids were tested for their cytotoxic effects against K562 cells. Compound 9 was the most potent with an IC50 value of 0.69 microg/ml.
Li
Xian
X
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Longquan Road, Heilongtan 610, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Xiao
Weilie
W
Pu
Jianxin
J
Ban
Lili
L
Shen
Yunheng
Y
Weng
Zhiying
Z
Li
Shenghong
S
Sun
Handong
H
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D004224:Diterpenes; D045786:Diterpenes, Kaurane; C002627:kaurene