The PADAM syndrome and its clinical manifestations: the muscle mass.
Many animal and in vitro studies suggest that testosterone can affect body composition. Therefore, the age-related decline in testosterone (T) likely contributes to the concomitant decrease in lean mass documented in men. While observational data in humans are not conclusive, intervention studies suggest that aged men could benefit from T replacement in term of muscle mass preservation. However, its potential positive impact on strength and functional status is unproven.
Denti
L
L
Clinica Geriatrica, Azienda Ospedaliera di Parma, 43100 Parma, Italy. ldenti@ao.pr.it
D000368:Aged; D000369:Aged, 80 and over; D047649:Andropause / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D006801:Humans; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000503:physiopathology*; D013739:Testosterone / Q000172:deficiency / Q000502:physiology
D013739:Testosterone