Dependence of molecular properties on proteomic family for marketed oral drugs.
An association of drugs with their proteomic family reveals that molecular properties of drugs targeting proteases, lipid and peptide G-protein-coupled receptors (GPCRs), and nuclear hormone receptors significantly exceed limits for some properties in the "rule of five", while drugs targeting cytochrome P450s, biogenic amine GPCRs, and transporters have significantly lower values for certain properties. Also, the variation in drug targets appears to be a factor explaining increasing molecular weight over time.
Vieth
Michal
M
Lilly Research Laboratories and Discovery Informatics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
Sutherland
Jeffrey J
JJ
D000284:Administration, Oral; D016208:Databases, Factual; D004345:Drug Industry; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D020543:Proteome / Q000737:chemistry*; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations; D020543:Proteome