title: [Antioxidants in vitiligo treatment].
abstract: Oxidative stress has a definite role in genesis of several diseases and there is a possibility of its correction. In the latest period oxidative stress in the skin related with vitiligo is the subject of special interest. Experimentally has been proven that keratinocytes obtained from the vitiligo areas generate big amount of superoxide anions - reactive forms of oxygen and nitric oxide. It is known that in patients suffering from generalized form of vitiligo there is a disbalance between oxidative and antioxidative systems. Considering above, the preparation vitix (containing antioxidants, superoxide dismutaze and catalase) for treatment of vitiligo is important. 25 patients (5-63 years old) with different clinical forms of vitiligo with duration of 1-5 years were included in the study. The drug was prescribed in tablet form for using 1 times a day irrespective of ingestion and 2-times a day for local application on affected sites. Homogeneous repigmentation of affected areas, without sharp contrast between affected, newly pigmented and normal skin areas were observed. Absence of side effects and good tolerance allow us to recommend Vitix for the treatment of vitiligo.
authors.forename: N V
authors.initials: NV
authors.lastname: Tsiskarishvili
authors.forename: Ts I
authors.initials: TsI
authors.lastname: Tsiskarishvili
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D002374:Catalase / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D016896:Treatment Outcome; D014820:Vitiligo / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; C507649:Vitix