Isolated biliary granulocytic sarcoma followed by acute myelogeneous leukemia with multilineage dysplasia: a case report and literature review.
Granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells. Primary involvement of the biliary tract without evidence of leukemia is exceedingly rare. Here, we report an isolated biliary granulocytic sarcoma in a 30-yr-old man who presented with jaundice, fever, and chill without any evidence of leukemia. However, five months after the diagnosis, he developed acute myelogenous leukemia with multilineage dysplasia and chromosomal abnormality. A rare possibility of biliary granulocytic sarcoma should be considered as a differential diagnosis in patients with obstructive jaundice. A histologic evaluation by aggressive diagnostic intervention is important and may improve prognosis.
Sung
Chang Ohk
CO
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ko
Young Hyeh
YH
Park
Cheol Keun
CK
Jang
Kee Taek
KT
Heo
Jin Seok
JS
D000328:Adult; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000473:pathology*; D001652:Bile Ducts / Q000378:metabolism / Q000473:pathology; D019070:Cell Lineage; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D011379:Prognosis; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000473:pathology*; D014057:Tomography, X-Ray Computed