title: Recovery from giant cell myocarditis with ECMO support and utilisation of polyclonal antithymocyte globulin: a case report.
abstract: Giant cell myocarditis (GCM) is a rare and frequently fatal disorder. Patients suffer of ventricular arrhythmias or congestive heart failure. Here we describe a patient with cardiogenic shock and histological verified GCM. The patient was saved by implantation of extracorporeal membrane oxygeneation (ECMO) device and concomitant application of Rabbit antithymocyte globuline (rATG, Thymoglobulin, Sangstat), cyclosporine, and steroids in the acute event. 12 months after the crisis the patient evidences NYHA class I heart function and only a moderate impairment of heart function (EF 55%). The novel utilisation of ECMO in GCM related cardiogenic shock and application of rATG have prooven life-saving in this patient. Studies utilizing rATG in the treatment of GCM are warrented.
authors.affiliation: Department of Cardiothoracic Surgery, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria. hjankersmit@hotmail.com
authors.forename: H J
authors.initials: HJ
authors.lastname: Ankersmit
authors.forename: R
authors.initials: R
authors.lastname: Ullrich
authors.forename: B
authors.initials: B
authors.lastname: Moser
authors.forename: K
authors.initials: K
authors.lastname: Hoetzenecker
authors.forename: S
authors.initials: S
authors.lastname: Hacker
authors.forename: P
authors.initials: P
authors.lastname: German
authors.forename: C
authors.initials: C
authors.lastname: Krenn
authors.forename: R
authors.initials: R
authors.lastname: Horvat
authors.forename: M
authors.initials: M
authors.lastname: Grimm
authors.forename: E
authors.initials: E
authors.lastname: Wolner
authors.forename: A
authors.initials: A
authors.lastname: Zuckermann
mesh_terms: D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000961:Antilymphocyte Serum; D007155:Immunologic Factors