Resorptive response of rhBMP2 simulating infection in an anterior lumbar interbody fusion with a femoral ring.
RhBMP-2 has been available for general use since July of 2002. No literature regarding its use with femoral ring allografts exists. This case demonstrates how a resorptive effect of rhBMP-2 with a femoral ring allograft on host bone at the interbody fusion site can easily be confused with infection. Spine surgeons should be aware of this effect to avoid unnecessary antibiotic use or additional surgery.
Hansen
Stephen M
SM
Indiana Spine Group, Indianapolis, 46260, USA.
Sasso
Rick C
RC
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D001862:Bone Resorption / Q000139:chemically induced* / Q000175:diagnosis*; D016025:Bone Transplantation / Q000009:adverse effects; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D005269:Femur / Q000637:transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D013123:Spinal Fusion / Q000009:adverse effects* / Q000295:instrumentation; D013530:Surgical Wound Infection / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000009:adverse effects*
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta