title: Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides.
abstract: A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Almasirad
authors.forename: Rohollah
authors.initials: R
authors.lastname: Hosseini
authors.forename: Hassan
authors.initials: H
authors.lastname: Jalalizadeh
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Rahimi-Moghaddam
authors.forename: Nazila
authors.initials: N
authors.lastname: Abaeian
authors.forename: Maryam
authors.initials: M
authors.lastname: Janafrooz
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abbaspour
authors.forename: Vahid
authors.initials: V
authors.lastname: Ziaee
authors.forename: Afshin
authors.initials: A
authors.lastname: Dalvandi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006834:Hydrazines; D062367:ortho-Aminobenzoates; C001209:fenamic acid