Fatty acid synthase and cancer: new application of an old pathway.
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer.
Kuhajda
Francis P
FP
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. fkuhajda@jhmi.edu
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000201:enzymology*; D011471:Prostatic Neoplasms / Q000201:enzymology
D064429:Fatty Acid Synthases