Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC).
E- cadherin is a member of the cadherin superfamily known as the main mediator of the cell- cell calcium dependent adhesion interactions. Research evidence also yields to this adhesion molecule an important role in carcinogenesis and tumor progression. This review focuses on the differential expression of E- cadherin in the various anatomic sites of the human body where HNSCC arises. Controversies in the results of various studies are discussed and possible prospects for application of all this developing knowledge to prognosis and therapy of the disease are briefly mentioned.
Georgolios
A
A
Department of Physiology, Clinical Unit, Medical Faculty, University of Ioannina, Ioannina, Greece.
Batistatou
A
A
Manolopoulos
L
L
Charalabopoulos
K
K
D000818:Animals; D015820:Cadherins / Q000096:biosynthesis* / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis
D015820:Cadherins