[Study on the position of genes responsible for gallstone disease in Chinese population].
OBJECTIVE
To search the susceptibility genes of gallstone disease in Chinese population.


METHODS
A genome wide scan was performed in twelve families with gallstone disease using fluorescence-labeled microsatellite markers. Genehunter and Batchlink of Linkage package were used for non- parameter and parameter linkage analysis to search the linkage loci on chromosomes.


RESULTS
Four loci of D3S1266, D4S406, D9S1682 and D11S902 showed suggestive evidence for linkage. nonparametric linkage analysis (NPL)-score of D4S406 and D9S1682 was 1.77 (P = 0.05) and 1.92 (P = 0.04) respectively. The corresponding logarithm of the odds ratio (LOD)-score of D3S1266, D9S1682 were 1.35 and 2.07, and showed a rise of LOD-score from 1.35 to 2.71, 2.07 to 2.40 respectively when families with later-found patients or with higher triglyceride level were analyzed alone. Transmitted disequilibrium test of D11S902 showed a P-value of 0.0027.


CONCLUSIONS
Chromosome 3, 4, 9 and 11 may contain genes involved in gallstone disease in Chinese population, and chromosome 3, 9 may hide genes that are liked to gallstone disease in families with later-found patients or with higher triglyceride concentration.
Qin
Jian
J
Department of Surgery, Ruijin Hospital, the Second Medical University of Shanghai, Shanghai 200025, China.
Han
Tian-quan
TQ
Yuan
Wen-tao
WT
Fei
Jian
J
Jiang
Zhi-hong
ZH
Zhang
Jing
J
Wang
Yi
Y
Huang
Wei
W
Zhang
Sheng-dao
SD
D000367:Age Factors; D044466:Asian People; D015992:Body Mass Index; D041761:Cholecystolithiasis / Q000208:ethnology / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree