Sulfur mustard-induced neutropenia: treatment with granulocyte colony-stimulating factor.
Although best known as a blistering agent, sulfur mustard (HD) can also induce neutropenia in exposed individuals, increasing their susceptibility to infection. Granulocyte colony-stimulating factor (G-CSF) and pegylated G-CSF (peg-G-CSF) have been approved by the U.S. Food and Drug Administration as hematopoietic growth factors to treat chemotherapy-induced neutropenia. The goal of this study was to determine the effectiveness of G-CSF and peg-G-CSF in ameliorating HD-induced neutropenia. African green monkeys (Chlorocebus aethiops) were challenged with HD and, at 1, 3, 5, or 7 days after exposure, G-CSF therapy (10 microg/kg per day for 21 days) was initiated. Peg-G-CSF (300 microg/kg, single treatment) was similarly tested, with treatment given at 3 days after exposure. Untreated HD-exposed animals recovered from neutropenia 28 days after exposure, whereas G-CSF- or peg-G-CSF-treated animals recovered 8 to 19 days after exposure (p < 0.05). These results indicate that G-CSF or peg-G-CSF may provide Food and Drug Administration-approved treatments that will reduce the duration of HD-induced neutropenia.
Anderson
Dana R
DR
Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA.
Holmes
Wesley W
WW
Lee
Robyn B
RB
Dalal
Stephen J
SJ
Hurst
Charles G
CG
Maliner
Beverly I
BI
Newmark
Jonathan
J
Smith
William J
WJ
D000818:Animals; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D000882:Haplorhini; D008297:Male; D009151:Mustard Gas / Q000009:adverse effects*; D009503:Neutropenia / Q000139:chemically induced*; D014481:United States
D016179:Granulocyte Colony-Stimulating Factor; D009151:Mustard Gas