[Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy].
BACKGROUND
Procalcitonin (PCT) is widely accepted as an early marker of the severity of sepsis and its prognosis. This study was designed to evaluate the utility of PCT in the early diagnosis of immediate postoperative complications (infectious and non-infectious) following cephalic pancreatoduodenectomy (PD).


METHODS
Thirty-one patients who underwent elective PD were prospectively analyzed. The patients were divided into two groups according to the presence or absence of postoperative complications. Plasma PCT concentrations were determined by an immunochromatographic method. The correlation between PCT concentrations and the presence of complications, as well as the existence of statistically significant differences in PCT concentrations between the 2 groups of patients, were analyzed. The value of plasma PCT concentrations in predicting complications compared with that of other biochemical variables (C-reactive protein, lactic acid, base excess) and clinical parameters (systemic inflammatory response syndrome) was analyzed.


RESULTS
Significant differences in PCT concentrations were found between the two groups. An inverse correlation between marker levels and patient outcome was observed. The variables that best predicted the development of complications were PCT concentrations and axillary temperature.


CONCLUSIONS
Plasma PCT should be taken into account as a useful marker for postoperative clinical course in the follow-up of PD and for the early detection of non-infectious complications.
Bianchi
Ricardo A
RA
Servicio de Cirugía General, Hospital General de Agudos Dr. Cosme Argerich, Ciudad Autónoma de Buenos Aires, Argentina.
Haedo
Ana S
AS
Romero
María C
MC
D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016577:Pancreaticoduodenectomy / Q000379:methods*; D011182:Postoperative Care; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000209:etiology*
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide