Impact of stent design on clinical outcome after coronary stent implantation.
Coronary stents have considerably improved both immediate and late results after coronary angioplasty, by limiting elastic recoil and vascular remodeling, but their use does not eliminate restenosis, caused mainly by neointimal hyperplasia. Stents are now implanted in over 70% of percutaneous coronary interventions. More than 50 coronary stents have already been approved in Europe and over 20 stents are commercially available in the USA, raising the question: which device is best suitable for which lesion? Several in vitro experiments revealed significant differences in expansion characteristics of coronary stents, related to the strut design and metallic composition. Animal studies were performed to determine the influence of stent design on the patterns and extent of neointimal hyperplasia. However, the clinical results of randomized trials comparing stent types in humans have not always reflected laboratory findings. This article is a critical overview of experimental and clinical data concerning the impact of stent design on the early and late clinical outcome after coronary stent implantation.