Bisphosphonate-induced osteonecrosis of the jaws: a case report and literature review.
Bisphosphonates are nonmetabolized analogues of pyrophosphate that are used for treating skeletal complications secondary to bone metastases. These drugs are capable of localizing to bone and inhibiting osteoclastic activity; however, their exact mechanisms of action remain unclear. Recently, it has been documented that administration of bisphosphonates has been associated with osteonecrosis of the jaws. This article details the case of a woman who received intravenous administration of bisphosphonate for metastatic breast cancer and subsequently developed osteonecrosis in both the maxillary and mandibular jaws.
Tsai
Wellington S
WS
Department of Dentistry, Jersey Shore University Medical Center, Neptune, USA.
Haghighi
Kayvon
K
Placa
Sally-Jo
SJ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D002710:Chlorhexidine / Q000627:therapeutic use; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008336:Mandibular Diseases / Q000139:chemically induced*; D008439:Maxillary Diseases / Q000139:chemically induced*; D008443:Maxillary Sinus / Q000187:drug effects; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D010254:Paranasal Sinus Diseases / Q000139:chemically induced; D010404:Penicillin V / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D002710:Chlorhexidine; D010404:Penicillin V