Dual role of the adaptor protein SLP-65: organizer of signal transduction and tumor suppressor of pre-B cell leukemia.
B cell development is characterized by a coordinated progression through defined stages that are controlled at several checkpoints. Signals from the pre-B cell receptor (pre-BCR) are essential for regulated transition from the pre-B cell stage. The adaptor protein SLP-65 plays a key role in this signaling pathway. Recent findings indicate an additional function of SLP-65 as a tumor suppressor that regulates pre-B cell proliferation. We will discuss here the potential mechanisms by which SLP-65 controls the pre-B cell checkpoint.
Herzog
Sebastian
S
Max-Planck-Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany.
Storch
Bettina
B
Jumaa
Hassan
H
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D010750:Phosphoproteins / Q000502:physiology*; D054420:Pre-B Cell Receptors; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000503:physiopathology*; D011505:Protein-Tyrosine Kinases; D011947:Receptors, Antigen, B-Cell; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; C113939:B cell linker protein; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D010750:Phosphoproteins; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell; D025521:Tumor Suppressor Proteins; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase