title: Contrast-enhanced dynamic MR nephrography using the TurboFLASH navigator-gating technique in children.
abstract: The purpose of this work was to test the feasibility of an MR examination protocol for the comprehensive assessment of renal morphology, excretion and split renal function using a navigator-gated TurboFLASH sequence. A navigator-gated T1-weighted single-slice TurboFLASH sequence suitable for dynamic MR urography and nephrography was implemented. A protocol was developed allowing for assessment of urinary excretion and split renal function by recording the renal clearance of a gadolinium (Gd) diethylene-triamine-pentacetic-acid (DTPA) bolus. Ten patients aged between 14 months and 14 years (mean age 4.8+/-4.6 years) were evaluated with the following indications: pelvicalyceal dilatation (n=4), follow-up after pyeloplasty (n=1), duplex systems (n=3), large renal cyst (n=1), and renal insufficiency (n=1). Dynamic MR urography and MR split renal function were compared to MAG3 scintigraphy. Evaluation of morphology, excretion and function required 50-60 minutes examination time, plus 10 minutes for post-processing. The TurboFLASH sequence yielded image acquisition at nearly identical diaphragm positions allowing for accurate region-of-interest evaluation within the renal parenchyma and the urinary passage. Static and dynamic MR urography showed the morphology of the urinary tract and excretion with sufficient diagnostic imaging quality, and the results were in diagnostic compliance with scintigraphy. MRI and scintigraphy yielded similar results for split renal function with a correlation coefficient of R=0.968 determined by linear regression. Our conclusions were that the method is robust, easy to perform on a clinical 1.5 T MRI system, rapid to evaluate and post-process and, therefore, easy to incorporate into clinical routine. Compared to scintigraphy, the higher spatial resolution of the MR examination provides additional important information improving the management of the pediatric patients without the application of radioactive tracers.
authors.affiliation: Department of Diagnostic Radiology, Section of Experimental Radiology, Eberhard-Karls University, Hoppe Seyler Strasse 3, 72076, Tübingen, Germany. andreas.boss@med.uni-tuebingen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Boss
authors.forename: Juergen F
authors.initials: JF
authors.lastname: Schaefer
authors.forename: Petros
authors.initials: P
authors.lastname: Martirosian
authors.forename: Hans-Walter
authors.initials: HW
authors.lastname: Hacker
authors.forename: Kassa
authors.initials: K
authors.lastname: Darge
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Klaus
authors.initials: K
authors.lastname: Küper
authors.forename: Fritz
authors.initials: F
authors.lastname: Schick
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D019544:Equipment Failure Analysis; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis*; D007677:Kidney Function Tests / Q000295:instrumentation* / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA