title: The new global multiple sclerosis severity score (MSSS) correlates with axonal but not glial biomarkers.
abstract: This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SM135, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SM134 to NfH-SM135) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P = 0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS.
authors.affiliation: Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK. a.petzold@ion.ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Petzold
authors.forename: M I
authors.initials: MI
authors.lastname: Eikelenboom
authors.forename: G
authors.initials: G
authors.lastname: Keir
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
authors.forename: B M J
authors.initials: BM
authors.lastname: Uitdehaag
authors.forename: E J
authors.initials: EJ
authors.lastname: Thompson
authors.forename: G
authors.initials: G
authors.lastname: Giovannoni
mesh_terms: D000328:Adult; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003943:Diagnostic Techniques, Neurological / Q000592:standards; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology*; D009410:Nerve Degeneration / Q000134:cerebrospinal fluid / Q000473:pathology; D016900:Neurofilament Proteins / Q000378:metabolism; D009457:Neuroglia / Q000473:pathology*; D010766:Phosphorylation; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016900:Neurofilament Proteins; C051774:neurofilament protein H