Preparation of 7-Halo-indoles by Thallation of N-formylindoline and their attempted use for synthesis of the right-hand segment of chloropeptin.
7-Substituted (Cl, Br, I) indoles were synthesized by using thallation of N-formylindoline as a key reaction. Two precursor tripeptides for the right-hand segment of chloropeptin were synthesized by using (R)-7'-iodo and 7'-bromotryptophans derived from each 7-substituted indole (I, Br) obtained by the above procedure.
Yamada
Yaeko
Y
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Arima
Shiho
S
Okada
Chiharu
C
Akiba
Ai
A
Kai
Toshitsugu
T
Harigaya
Yoshihiro
Y
D002733:Chlorophenols / Q000138:chemical synthesis*; D007211:Indoles / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011724:Pyridazines / Q000737:chemistry; D013793:Thallium / Q000737:chemistry*
D002733:Chlorophenols; D007211:Indoles; D010456:Peptides, Cyclic; D011724:Pyridazines; C090485:chloropeptin I; C057812:indoline; D013793:Thallium