Aurora kinases A and B and familial breast cancer risk.
Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR=1.45, 95% CI=1.05-2.0, P=0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.
Tchatchou
Sandrine
S
Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. s.tchatchou@dkfz.de
Wirtenberger
Michael
M
Hemminki
Kari
K
Sutter
Christian
C
Meindl
Alfons
A
Wappenschmidt
Barbara
B
Kiechle
Marion
M
Bugert
Peter
P
Schmutzler
Rita K
RK
Bartram
Claus R
CR
Burwinkel
Barbara
B
D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D001483:Base Sequence; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D017931:DNA Primers; D007527:Isoenzymes; C576917:AURKA protein, human; C576921:AURKB protein, human; D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases