title: Aurora kinases A and B and familial breast cancer risk.
abstract: Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR=1.45, 95% CI=1.05-2.0, P=0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.
authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. s.tchatchou@dkfz.de
authors.forename: Sandrine
authors.initials: S
authors.lastname: Tchatchou
authors.forename: Michael
authors.initials: M
authors.lastname: Wirtenberger
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Christian
authors.initials: C
authors.lastname: Sutter
authors.forename: Alfons
authors.initials: A
authors.lastname: Meindl
authors.forename: Barbara
authors.initials: B
authors.lastname: Wappenschmidt
authors.forename: Marion
authors.initials: M
authors.lastname: Kiechle
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Rita K
authors.initials: RK
authors.lastname: Schmutzler
authors.forename: Claus R
authors.initials: CR
authors.lastname: Bartram
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
mesh_terms: D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D001483:Base Sequence; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D017931:DNA Primers; D007527:Isoenzymes; C576917:AURKA protein, human; C576921:AURKB protein, human; D064096:Aurora Kinase A; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases