Reactions between beta-casomorphins-7 and 5-HT2-serotonin receptors.
Radioreceptor analysis showed that human beta-casomorphin-7 displaced 3H-spiperone from 5-HT2-serotonin receptors of the rat cerebral frontal cortex: EC50 8 +/- 1 microM. Human and bovine beta-casomorphin-7 dose-dependently blocked serotonin-induced human platelet aggregation: IC50 5 +/- 1 and 20 +/- 4 microM, respectively. It was proved that beta-casomorphins-7 act as 5-HT2-serotonin receptor antagonists; one of the mechanisms of their biological effects is presumably associated with modulation of the serotoninergic system.
Sokolov
O Yu
OY
Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. sokolov@rcmh.msk.ru
Pryanikova
N A
NA
Kost
N V
NV
Zolotarev
Yu A
YA
Ryukert
E N
EN
Zozulya
A A
AA
D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D020128:Inhibitory Concentration 50; D007650:Ketanserin / Q000494:pharmacology; D010446:Peptide Fragments / Q000378:metabolism*; D010974:Platelet Aggregation; D011485:Protein Binding; D051381:Rats; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology
D018492:Dopamine Antagonists; D004723:Endorphins; D010446:Peptide Fragments; D044348:Receptors, Serotonin, 5-HT2; D012702:Serotonin Antagonists; D013134:Spiperone; C041128:beta-casomorphin 7; D007650:Ketanserin