title: Customizing a commercial rule base for detecting drug-drug interactions.
abstract: We developed and implemented an adverse drug event system (PharmADE) that detects potentially dangerous drug combinations using a commercial rule base. While commercial rule bases can be useful for rapid deployment of a safety net to screen for drug-drug interactions, they sometimes do not provide the desired rule sensitivity. We implemented methods for enhancing commercial drug-drug interaction rules while preserving the original rule base architecture for easy and low cost maintenance.
authors.affiliation: Washington University School of Medicine, Department of Internal Medicine, St. Louis, MO, USA.
authors.forename: Ervina
authors.initials: E
authors.lastname: Resetar
authors.forename: Richard M
authors.initials: RM
authors.lastname: Reichley
authors.forename: Laura A
authors.initials: LA
authors.lastname: Noirot
authors.forename: Wm Claiborne
authors.initials: WC
authors.lastname: Dunagan
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bailey
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D004347:Drug Interactions; D004360:Drug Therapy, Computer-Assisted; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008508:Medication Errors / Q000517:prevention & control; D008510:Medication Systems, Hospital