title: Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
abstract: When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Abeta oligomers has a central role in the pathogenesis of Alzheimer disease.
authors.affiliation: Centre for Research in Neurodegenerative Diseases, 6 Queen's Park Crescent West, Toronto, Ontario M5S 3H2 Canada. j.mclaurin@utoronto.ca
authors.forename: JoAnne
authors.initials: J
authors.lastname: McLaurin
authors.forename: Meredith E
authors.initials: ME
authors.lastname: Kierstead
authors.forename: Mary E
authors.initials: ME
authors.lastname: Brown
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Hawkes
authors.forename: Mark H L
authors.initials: MH
authors.lastname: Lambermon
authors.forename: Amie L
authors.initials: AL
authors.lastname: Phinney
authors.forename: Audrey A
authors.initials: AA
authors.lastname: Darabie
authors.forename: Julian E
authors.initials: JE
authors.lastname: Cousins
authors.forename: Janet E
authors.initials: JE
authors.lastname: French
authors.forename: Melissa F
authors.initials: MF
authors.lastname: Lan
authors.forename: Fusheng
authors.initials: F
authors.lastname: Chen
authors.forename: Sydney S N
authors.initials: SS
authors.lastname: Wong
authors.forename: Howard T J
authors.initials: HT
authors.lastname: Mount
authors.forename: Paul E
authors.initials: PE
authors.lastname: Fraser
authors.forename: David
authors.initials: D
authors.lastname: Westaway
authors.forename: Peter
authors.initials: P
authors.lastname: St George-Hyslop
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000517:prevention & control; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry* / Q000187:drug effects; D000818:Animals; D003511:Cyclohexanols / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D018697:Nootropic Agents / Q000627:therapeutic use; D010641:Phenotype; D058225:Plaque, Amyloid / Q000187:drug effects / Q000473:pathology; D013569:Synapses / Q000473:pathology / Q000502:physiology
chemical_list: D016564:Amyloid beta-Protein Precursor; D003511:Cyclohexanols; D018697:Nootropic Agents