Celiac disease prevalence in Brazilian dilated cardiomyopathy patients.
Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti-h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti-h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.
De Bem
Ricardo Schmit T
RS
Service of Gastroenterology and Digestive Endoscopy, Clinical Hospital, Federal University of Paraná, Curitiba, Paraná, Brazil. ricsdebem@netpar.com.br
Da Ro Sa Utiyama
Shirley Ramos
SR
Nisihara
Renato Mitsunori
RM
Fortunato
Jerônimo Antônio
JA
Tondo
Josué Augusto
JA
Carmes
Eliane Ribeiro
ER
Souza
Raquel Almada E
RA
Pisani
Julio César
JC
Amarante
Heda Maria Barska Dos Santos
HM
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000276:immunology; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D015995:Prevalence
D001323:Autoantibodies; D007070:Immunoglobulin A