Controlled release from a nanocarrier entrapped within a microcarrier.
This study illustrates the entrapment of the dye molecule fluorescein sodium salt (FSS) by hydrogel nanoparticles, which are in turn confined inside a water-in-oil-in-water double-emulsion globule, and its subsequent release by the action of the competing agent hydrochloric acid (HCl). Thus, a "double carrier" concept is being introduced in which a nanoscale delivery vehicle is being transported by a microscale delivery vehicle in order to simultaneously take advantage of both systems. This may facilitate storage and handling while protecting the active substance and improving its action upon application.
Rojas
Edith C
EC
Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, USA.
Sahiner
Nurettin
N
Lawson
Louise B
LB
John
Vijay T
VT
Papadopoulos
Kyriakos D
KD
D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004655:Emulsions; D019793:Fluorescein / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008832:Microchemistry; D008962:Models, Theoretical; D015394:Molecular Structure; D053758:Nanoparticles
D003692:Delayed-Action Preparations; D004655:Emulsions; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019793:Fluorescein