title: Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga, Ishige okamurae.
abstract: The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC(50) values of 9.1 microM and 25.2 microM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes.
authors.affiliation: Department of Crops Biotechnology, College of Life Sciences and Natural Resources, Jinju National University, Jinju, Gyeongnam 660-758, Korea.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Ahn
authors.forename: K-D
authors.initials: KD
authors.lastname: Yoon
authors.forename: C Y
authors.initials: CY
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: C-G
authors.initials: CG
authors.lastname: Shin
authors.forename: J
authors.initials: J
authors.lastname: Kim
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D019427:HIV Integrase / Q000187:drug effects*; D019428:HIV Integrase Inhibitors / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology*; D000459:Phaeophyceae; D010936:Plant Extracts / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D019428:HIV Integrase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; C513811:diphlorethohydroxycarmalol; D019427:HIV Integrase; D054303:HIV Reverse Transcriptase