Development of a pressure nociceptive threshold testing device for evaluation of analgesics in cats.
A pressure analgesiometric device was developed for unrestrained cats. Eleven cats were studied. Stimulation was via three rounded pins within a bracelet on the forearm. The pins were advanced by manual bladder inflation. Bladder pressure was measured using a strain gauge pressure transducer. The threshold was recorded at the behavioural end point. Thresholds were measured at 5 and 15min intervals for 2-4h, after removal/replacement of the cuff, for 120min after SC butorphanol (0.4mg/kg), and with mild skin inflammation at the testing site. Data were analysed using ANOVA. Pressure thresholds in untreated cats were around 150mmHg. The minimum interval for testing was established as 15min. Data were reproducible over 4h and beyond 24h. Thresholds in 5 cats increased (P<0.05) above baseline for 45min after butorphanol with a maximum increase of 270+/-182mmHg at 10min. Thresholds decreased with inflammation. The method appears suitable for feline analgesia investigations.
Dixon
M J
MJ
Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK.
Taylor
P M
PM
Steagall
P V M
PV
Brondani
J T
JT
Luna
S P L
SP
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D002077:Butorphanol / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000662:veterinary; D007616:Kaolin / Q000633:toxicity; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010147:Pain Measurement / Q000295:instrumentation / Q000662:veterinary*
D000700:Analgesics; D007616:Kaolin; D002077:Butorphanol