Synthesis of an X-ray opaque biodegradable copolyester by chemical modification of poly (epsilon-caprolactone).
Poly (epsilon-caprolactone-co-alpha-iodo-epsilon-caprolactone) was synthesized by binding iodine to PCL chain bearing carbanionic site on alpha-position of carbonyl groups using lithium diisopropylamide. Copolyesters containing from 10% to 25% of iodo-units were thus obtained. Viscoelastic properties (modulus, loss angle), thermal properties (T(m), T(c), DeltaH(m)), crystallinity and in vitro degradability of this new type of copolymers were measured. Their opacity to X-rays was assessed, and appeared high enough to be of interest for biomedical applications.
Nottelet
Benjamin
B
C.R.B.A.-U.M.R C.N.R.S. 5473, Faculty of Pharmacy, Montpellier I University, 15, Avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France.
Coudane
Jean
J
Vert
Michel
M
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D002208:Caproates / Q000737:chemistry; D003460:Crystallization; D006868:Hydrolysis; D007455:Iodine / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D013816:Thermodynamics; D013997:Time Factors; D014783:Viscosity; D014965:X-Rays
D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; D011091:Polyesters; C016240:polycaprolactone; C121056:caprolactone; D007455:Iodine