title: Applying mobile genetic elements for genome analysis and evolution.
abstract: Transposable elements (TEs) are ubiquitous components of all living organisms, and in the course of their coexistence with their respective host genomes, these parasitc DNAs have played important roles in the evolution of complex genetic networks. The interaction between mobile DNAs and their host genomes are quite diverse, ranging from modifications of gene structure and regulation to alterations in general genome architecture. Thus during evolutionary time these elements can be regarded as natural molecular tools in shaping the organization, structure, and function of eukaryotic genes and genomes. Based on their intrinsic properties and features, mobile DNAs are widely applied at present as a technical "toolbox," essential for studying a diverse spectrum of biological questions. In this review, we aim to summarize both the evolutionary impact of TEs on genome evolution and their valuable and diverse methodological applications as molecular tools.
authors.affiliation: Laboratories of Genome Dynamics, Center of Anatomy and Cell Biology, Medical University of Vienna, Waehringerstr. 10, 1090 Vienna, Austria. wolfgang.miller@meduniwien.ac.at
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Miller
authors.forename: Pierre
authors.initials: P
authors.lastname: Capy
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D019143:Evolution, Molecular; D016678:Genome / Q000235:genetics*; D023281:Genomics / Q000379:methods*
chemical_list: D004251:DNA Transposable Elements