Imaging the choreography of lymphocyte trafficking and the immune response.
The functioning of the immune system depends upon exquisitely choreographed interactions between its cellular constituents. Two-photon microscopy now enables us to visualize cell motility and cell-cell interactions deep within intact tissues and organs, both in explanted preparations and in vivo. Real-time immunoimaging techniques have illuminated the roles of random and chemokine-driven motility for cellular search strategies, the complex dynamics of cellular interactions, and the micro-anatomical localization and control of lymphocyte trafficking. Recently, advances have been made in these areas of research, as exemplified by studies investigating T cell-dendritic cell interactions, T cell-B cell interactions, and the regulation of lymphocyte egress from the lymph node.
Cahalan
Michael D
MD
Department of Physiology & Biophysics and Neurobiology & Behavior, University of California, Irvine, 92697, USA.
Parker
Ian
I
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D003952:Diagnostic Imaging; D006801:Humans; D008853:Microscopy / Q000379:methods; D017785:Photons; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*