title: A telephone-based intervention for depression in HIV patients: negative results from a randomized clinical trial.
abstract: To determine if a telephone support behavioral intervention improves depressive symptoms among HIV positive outpatients, we enrolled 177 persons with Beck Depression Inventory (BDI) scores scores of >/=10. Participants were randomized to receive up to 12 scheduled psycho-educational calls over 6 months or to an assessment-only control condition. Co-enrolled informal caregivers of HIV patients received the same telephone intervention in parallel. Among the 160 (90.4%) participants who were re-interviewed at 6 months, 56% were male, and 41% were Caucasian, with a mean baseline BDI score of 22.7. Overall, participants' mean BDI scores improved 5.3 points from baseline, but intervention group differences on depression outcomes including 50% or greater reduction in BDI scores and depression remission were not statistically significant. In the full cohort, men were significantly more likely to improve than women. We conclude that a psycho-educational telephone support intervention did not reduce depressive symptoms for HIV patients more than an assessment-only control condition.
authors.affiliation: Department of Medicine, Rhode Island Hospital, 593 Eddy Street, MPB-1, Providence, RI 02903, USA. mstein@lifespan.org
authors.forename: Michael D
authors.initials: MD
authors.lastname: Stein
authors.forename: Debra S
authors.initials: DS
authors.lastname: Herman
authors.forename: Duane
authors.initials: D
authors.lastname: Bishop
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Anderson
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Trisvan
authors.forename: Rosalie
authors.initials: R
authors.lastname: Lopez
authors.forename: Timothy
authors.initials: T
authors.lastname: Flanigan
authors.forename: Ivan
authors.initials: I
authors.lastname: Miller
mesh_terms: D000328:Adult; D003419:Crisis Intervention / Q000379:methods; D003866:Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006679:HIV Seropositivity / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008297:Male; D013689:Telephone