Synthetic studies directed toward the proposed structure for heteroscyphic acid A.
A route to the carbon skeleton of the proposed structure for heteroscyphic acid A was developed utilizing a Mn(III)/Cu(II) mediated oxidative free-radical cyclization and nucleophilic addition to (3-methylpentadienyl)iron(1+) cation.
Chaudhury
Subhabrata
S
Department of Chemistry, Marquette University, P. O. Box 1881, Milwaukee, WI 53201-1881, USA.
Li
Shukun
S
Donaldson
William A
WA
D003300:Copper / Q000737:chemistry; D003500:Cyclization; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification; D005609:Free Radicals / Q000737:chemistry; D035926:Hepatophyta / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification
D045785:Diterpenes, Clerodane; D005609:Free Radicals; D010936:Plant Extracts; C519370:heteroscyphic acid A; D008345:Manganese; D003300:Copper