[Colorectal cancer: a risk-adapted screening and the role of the physician in the prevention of this cancer].
The benefit of colorectal cancer screening in the average-risk population, as well as in the presence of high risk genetic predispositions, has been validated by a significant reduction of the mortality associated with the disease. Several screening options are recognized and compliance with these measures remains a public health problem. The physician plays a key role in the promotion of the colorectal cancer screening. Collecting a precise family history is crucial for the identification of individuals at high risk. Validated clinical criteria are helpful for the identification of individuals with a genetic predisposition to colorectal cancer. Molecular screening for the main colorectal cancer predisposing genes should now be integrated in the clinical management of these patients and their families.
Chappuis
P O
PO
Service d'oncologie, Service de génétique médicale, HUG, 1211 Genève 14. pierre.chappuis@hcuge.ch
Hutter
P
P
D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D010819:Physician's Role; D012307:Risk Factors