Primary extramedullary plasmacytoma of the small intestine. A case report and review of the literature.
A case of primary extramedullary plasmacytoma of the small intestine in a 73-year-old Japanese woman was reported. The patient underwent local resection of the tumor, and showed no signs of local recurrence or dissemination of the disease after 28 months follow-up. The tumor cells had relatively large nuclei with distinct nucleoli and wide and slightly basophilic cytoplasm with a high N/C ratio which showed the morphology of atypical plasma cells. Immunohistochemical examination revealed that the tumor cells contained IgG gamma-type immunoglobulin in their cytoplasm but they did not contain IgA, IgM, IgD, and kappa-light chains. The tumor cells were also positive for CD79a and CD138 and negative for LCA, CD20 and CD45RO. These findings clearly indicated this case to be plasmacytoma.
Moriyama
H
H
Department of Oncological Science (Surgery II), Faculty of Medicine, The University of Oita, Oita, Japan. moriyama@nagato.or.jp
Kawahara
K
K
Noguchi
T
T
Kikuchi
R
R
Wada
S
S
Takeno
S
S
Kashima
K
K
D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis; D051925:CD79 Antigens / Q000096:biosynthesis; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D010954:Plasmacytoma / Q000175:diagnosis* / Q000473:pathology*; D011509:Proteoglycans / Q000096:biosynthesis; D053668:Syndecan-1; D053667:Syndecans; D013997:Time Factors; D016896:Treatment Outcome
D018951:Antigens, CD20; D051925:CD79 Antigens; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans; D017493:Leukocyte Common Antigens