title: Magnetic resonance imaging assessment of fibrovascular ingrowth into porous polyethylene orbital implants.
abstract: BACKGROUND
  To evaluate fibrovascular ingrowth into porous polyethylene orbital implants, using serial gadolinium (Gd)-enhanced magnetic resonance imaging (MRI).
  
  
  METHODS
  40 rabbits were divided into two groups, according to the surgical techniques used. Group 1 underwent enucleation of one eye and Medpor implantation, group 2 underwent evisceration and Medpor implantation. All subjects from each group were examined via MRI, and the implants were assessed histologically on the first, second, fourth and eighth postoperative weeks. The degree to which fibrovascular ingrowth occurred was then assessed by measuring the Gd-enhanced portion via MRI, as well as by histologic examination.
  
  
  RESULTS
  There was a significant correlation between the enhanced area on MRI and the fibrovascularized area observed upon histological examination in the two study groups (group 1: r = 0.850 P < 0.001, group 2: r = 0.788, P < 0.001). The area enhanced on MRI was 2.70% smaller in mean value than the fibrovascularized area observed upon histological examination. There was no differences in fibrovascular ingrowth between group 1 and 2. It was also found that there was no differences between the two groups with regard to the enhanced areas on MRI.
  
  
  CONCLUSIONS
  Gd-enhanced MRI study proved to be an excellent method for the assessment of fibrovascular ingrowth into the Medpor orbital implants, after both enucleation and evisceration.
authors.affiliation: Department of Ophthalmology, College of Medicine, Pusan National University, Busan, Korea. hychoi@pusan.ac.kr
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Hyun Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Boo Sup
authors.initials: BS
authors.lastname: Oum
authors.forename: Hak Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Do Youn
authors.initials: DY
authors.lastname: Park
mesh_terms: D000818:Animals; D015353:Eye Enucleation; D005347:Fibroblasts / Q000166:cytology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020273:Orbital Implants; D011095:Polyethylenes; D011817:Rabbits
chemical_list: C084562:Medpor; D011095:Polyethylenes