title: [Chronic left heart failure. A focus on the pathogenetic basis of medical treatment].
abstract: Chronic left heart failure is the result of the activation of pathophysiological mechanisms which over time lead to progressive deterioration of the cardiac function. As pharmacotherapy aims at these mechanisms and as treatment possibilities are increasing, we find it relevant to provide a survey. Treatment evidence is based mainly on systolic dysfunction. It consists of angiotensin-converting enzyme inhibitor, aldosterone antagonist, beta-blocker, digoxin and diuretics. Incorporation of evidence-based medicine and treatment of diastolic dysfunction should be focussed on in the future.
authors.affiliation: Odense Universitetshospital, Kardiologisk Afdeling B, Kardiologisk Forskningsenhed. manov99@student.sdu.dk
authors.forename: Marija Kristina
authors.initials: MK
authors.lastname: Novosel
authors.forename: Torben H
authors.initials: TH
authors.lastname: Haghfelt
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004077:Digoxin / Q000008:administration & dosage; D004232:Diuretics / Q000008:administration & dosage; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002316:Cardiotonic Agents; D004232:Diuretics; D000451:Mineralocorticoid Receptor Antagonists; D004077:Digoxin