title: Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.
abstract: The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
authors.affiliation: Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. ehniks@lumc.nl
authors.forename: E H
authors.initials: EH
authors.lastname: Niks
authors.forename: J B M
authors.initials: JB
authors.lastname: Kuks
authors.forename: B O
authors.initials: BO
authors.lastname: Roep
authors.forename: G W
authors.initials: GW
authors.lastname: Haasnoot
authors.forename: W
authors.initials: W
authors.lastname: Verduijn
authors.forename: B E P B
authors.initials: BE
authors.lastname: Ballieux
authors.forename: M H
authors.initials: MH
authors.lastname: De Baets
authors.forename: A
authors.initials: A
authors.lastname: Vincent
authors.forename: J J G M
authors.initials: JJ
authors.lastname: Verschuuren
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009157:Myasthenia Gravis / Q000235:genetics* / Q000276:immunology*; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C052238:HLA-DR14; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases