title: The last 11 years of Molteno implantation at the University of Cape Town. Refining our indications and surgical technique.
abstract: OBJECTIVE
  To analyse outcomes, factors influencing surgical success, and surgical technique of Molteno implantation over the past 11 years in order to identify ways of improving long-term control.
  
  
  METHODS
  Retrospective interventional review of case records of all consecutive patients undergoing Molteno implantation at Groote Schuur Hospital between 1/1/1991 and 31/12/2002. Data were recorded on an MSAccess database and processed using Kaplan-Meier survival curves and life table analysis.
  
  
  RESULTS
  We analysed 162 consecutive single-phase Molteno tube implantation procedures on 157 eyes of 148 patients with mean follow-up of 2.9 years. Intraocular pressure (IOP) dropped from a mean of 43.3 at booking to 19.1 at final follow-up. Overall 'complete success' was achieved in 30% and 'partial success' in 16%. A high preoperative IOP was a significant predictor of a high postoperative pressure. Pseudophakic patients had significantly better postoperative pressure control. Neovascular glaucoma was a risk factor for poor pressure control. Race, gender, previous surgery, uveitis, and trauma did not influence surgical outcome. Follow-up adjusted incidence of 2.4 cases of endophthalmitis per patient year was unexpectedly high. Tubes that migrated had been secured with absorbable sutures in 4/5 cases.
  
  
  CONCLUSIONS
  In this study, high preoperative IOPs were probably a significant contributing factor to relatively poor postoperative pressure control. Addressing this issue may aid in improving outcomes in future surgery. The high postoperative pressure outcomes suggest that single plate Molteno implantation is not an ideal way of achieving low target pressure in third world glaucoma patients.
authors.affiliation: University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa [corrected] malcomwoodcock@doctors.org.uk
authors.forename: M G L
authors.initials: MG
authors.lastname: Woodcock
authors.forename: J C
authors.initials: JC
authors.lastname: Richards
authors.forename: A D N
authors.initials: AD
authors.lastname: Murray
mesh_terms: D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D018465:Molteno Implants / Q000592:standards*; D011474:Prosthesis Design / Q000592:standards; D012189:Retrospective Studies; D013019:South Africa; D013223:Statistics as Topic; D016896:Treatment Outcome; D014792:Visual Acuity