title: MBP-PLP fusion protein-induced EAE in C57BL/6 mice.
abstract: Gene knock-out and knock-in mice are becoming increasingly indispensable for mechanism-oriented studies of EAE. Most gene-modified mice are on the C57BL/6 background, for which presently there are only two EAE models available, the MOG peptide 35-55 and the PLP 178-191 peptide induced disease. However, because MS is not a single pathogenic entity, different EAE models are required to reproduce and study its various features. Here we are introducing MBP-PLP fusion protein (MP4)-induced EAE for C57BL/6 mice. B cell- and CD8+ T cell-dependence, as well as multi-determinant recognition are among the unique features of this demyelinating EAE.
authors.affiliation: Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland OH, 44106, USA.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kuerten
authors.forename: Felix S
authors.initials: FS
authors.lastname: Lichtenegger
authors.forename: Susan
authors.initials: S
authors.lastname: Faas
authors.forename: Doychin N
authors.initials: DN
authors.lastname: Angelov
authors.forename: Magdalena
authors.initials: M
authors.lastname: Tary-Lehmann
authors.forename: Paul V
authors.initials: PV
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D004676:Myelin Basic Protein / Q000235:genetics / Q000276:immunology; D018991:Myelin Proteolipid Protein / Q000235:genetics / Q000276:immunology; D011993:Recombinant Fusion Proteins
chemical_list: C101821:MP4 protein, chimeric; D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein; D011993:Recombinant Fusion Proteins