title: An unusual case of Candida tropicalis and Candida krusei arthritis in a patient with acute myelogenous leukemia before chemotherapy.
abstract: A 79-year-old male with acute myelogenous leukemia developed acute right knee arthritis during admission, after the use of broad-spectrum antibiotics before chemotherapy. The initial synovial fluid sample appeared to be mildly inflammatory with a low white cell count. The fungal septic arthritis was not diagnosed until Candida tropicalis, a rare species of Candida, was isolated in the synovial fluid. Although fluconazole is effective in treating the microorganism, the untreated leukemia rendered the infection incurable and led to the growth of fluconazole-resistant Candida krusei. We reported the unusual case of fungal arthritis and reviewed the literature.
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec2, Shih-Pai Road, Taipei 112, Taiwan, Republic of China.
authors.forename: Hon-Pin
authors.initials: HP
authors.lastname: Wang
authors.forename: Yung-Feng
authors.initials: YF
authors.lastname: Yen
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Yuh-Lan
authors.initials: YL
authors.lastname: Chou
authors.forename: Chang-Youh
authors.initials: CY
authors.lastname: Tsai
authors.forename: Hsiao-Ning
authors.initials: HN
authors.lastname: Chang
authors.forename: Chung-Tei
authors.initials: CT
authors.lastname: Chou
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000382:microbiology / Q000473:pathology*; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology / Q000473:pathology*; D008297:Male; D013582:Synovial Fluid / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole