Synthesis and crystal structure of some transition metal complexes with a novel bis-Schiff base ligand and their antitumor activities.
Mononuclear complex of Zn(II) with a new bis-Schiff base ligand derived from 2,3-butanedione and thiosemicarbazide, [Zn(II)L.H2O].2DMF [L = (2E,2'E)-2,2'-(butane-2,3-diylidene)bis(hydrazinecarbothioamide)], and other transition metal ions [Cu(II), Mn(II), Co(II), Ni(II)] complexes have been prepared. The Zn(II) complex has been structurally characterized by X-ray crystallography. Among the five complexes, the Cu(II) complex has the novel highest antitumor activity.
Zhong
X
X
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, China.
Yi
J
J
Sun
J
J
Wei
H-L
HL
Liu
W-S
WS
Yu
K-B
KB
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D012545:Schiff Bases / Q000737:chemistry*; D013057:Spectrum Analysis; D028561:Transition Elements / Q000737:chemistry*
D000970:Antineoplastic Agents; D008024:Ligands; D012545:Schiff Bases; D028561:Transition Elements