Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination.
OBJECTIVE
To evaluate the association between obesity and the outcome of superovulation and intrauterine insemination (IUI) in infertile ovulatory women.


METHODS
Retrospective chart review.


METHODS
University-based infertility clinic.


METHODS
Three hundred thirty-three ovulatory women, grouped by body mass index (BMI) categories, who received superovulation and IUI for treatment of infertility.


METHODS
None.


METHODS



METHODS
cycle fecundity.


RESULTS
total dose of gonadotropins, serum level of E(2), and number of follicles >or=17 mm on the day of hCG injection.


RESULTS
Adjusted cycle fecundity was not different among BMI groups (underweight: 0.14 [95% CI: {0.07, 0.29}], normal weight: 0.12 [95% CI: {0.09, 0.16}], overweight: 0.17 [95% CI: {0.12, 0.24}], and obese: 0.14 [95% CI: {0.08, 0.23}]). Adjusted total gonadotropin dose (IU/cycle) was greater in obese women than in underweight or normal-weight women. Although the numbers of large follicles were not different, E(2) levels (pg/mL) were lower in obese women than in normal-weight and overweight women.


CONCLUSIONS
Our sample of ovulatory infertile women demonstrated that treatment-related cycle fecundity is unaffected by obesity. We conclude that obese, infertile ovulatory women require a greater dose of gonadotropins to achieve similar levels of superovulation than normal, underweight or overweight women.
Dodson
William C
WC
Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania, USA. wdodson@psu.edu
Kunselman
Allen R
AR
Legro
Richard S
RS
D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D007315:Insemination, Artificial / Q000706:statistics & numerical data*; D009765:Obesity / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D010414:Pennsylvania / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013223:Statistics as Topic; D016896:Treatment Outcome