title: Nodular herpes zoster with herpetic syringitis and no epidermal involvement in a patient with Burkitt lymphoma.
abstract: Herpes zoster (HZ) occurs with an increased incidence in immunosuppressed patients, in whom it frequently displays atypical clinical presentations. Herpetic syringitis, the involvement of the eccrine epithelium by herpes virus infection, is an infrequently described histologic pattern that has been rarely and almost exclusively reported in HIV-infected patients. We report the case of a woman with Burkitt lymphoma who developed 2 nodular, asymptomatic lesions while receiving treatment with chemotherapy and radiotherapy for her hematological disease. Histology showed viropathic changes in the epithelium of eccrine glands not in the epidermis. PCR was positive for varicella-zoster virus (VZV). Nodular herpes zoster seems to be an exceptional clinical presentation. We report another such case which is, as far as we know, the first report of herpetic syringitis with no concomitant epidermal involvement.
authors.affiliation: Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain. palomalav@yahoo.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Alonso-Pérez
authors.forename: Javier
authors.initials: J
authors.lastname: Fraga
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Delgado
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Aragüés
authors.forename: Syonghyun
authors.initials: S
authors.lastname: Nam-Cha
authors.forename: Amaro
authors.initials: A
authors.lastname: García-Díez
mesh_terms: D000328:Adult; D002051:Burkitt Lymphoma / Q000150:complications / Q000473:pathology* / Q000628:therapy / Q000821:virology; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D020405:Dermis / Q000473:pathology / Q000821:virology; D004439:Eccrine Glands / Q000473:pathology* / Q000821:virology; D004817:Epidermis / Q000473:pathology / Q000821:virology; D004848:Epithelium / Q000473:pathology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000473:pathology* / Q000821:virology; D006562:Herpes Zoster / Q000209:etiology / Q000473:pathology* / Q000821:virology; D014645:Herpesvirus 3, Human; D006801:Humans; D017193:Skin Diseases, Viral / Q000209:etiology / Q000473:pathology* / Q000821:virology