The use of mouse chromosome substitution strains to investigate the genetic regulation of pubertal timing.
Identification of genes underlying complex traits such as pubertal timing, is vital to our understanding of fundamental human developmental processes. Animal models can provide an important adjunct to more traditional human investigations. Within this review, we discuss the use and advantages of chromosome substitution strains in the investigation of factors that regulate the timing of the onset of puberty.
Nathan
Brandon M
BM
Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, United States.
Hodges
Craig A
CA
Palmert
Mark R
MR
D000818:Animals; D020296:Animals, Congenic / Q000235:genetics; D002869:Chromosome Aberrations; D003433:Crosses, Genetic; D008040:Genetic Linkage; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D011627:Puberty / Q000235:genetics; D040641:Quantitative Trait Loci; D012741:Sexual Maturation / Q000235:genetics*; D013995:Time