Parallel changes in resting muscle sympathetic nerve activity and blood pressure in a hypertensive OSAS patient demonstrate treatment efficacy.
Studies comparing the efficacy of continuous positive airway pressure (CPAP) versus surgery in correcting cardiovascular abnormalities in OSAS are lacking. We describe an OSAS patient with hypertension who responded favorably to CPAP treatment, whereas subsequent uvulopalatopharyngoplasty (UPPP) was less successful. While CPAP markedly lowered daytime muscle sympathetic nerve activity (MSNA) and blood pressure (BP), findings after UPPP were comparable to pre-treatment baseline. Thus, parallel changes in MSNA and BP demonstrated treatment efficacy.
Donadio
Vincenzo
V
Dept. of Neurological Sciences, University of Bologna, Bologna, Italy. donadio@neuro.unibo.it
Liguori
Rocco
R
Vetrugno
Roberto
R
Elam
Mikael
M
Falzone
Francesca
F
Baruzzi
Agostino
A
Montagna
Pasquale
P
D001794:Blood Pressure; D045422:Continuous Positive Airway Pressure; D004594:Electrophysiology; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation; D010159:Palate / Q000601:surgery; D010543:Peroneal Nerve / Q000503:physiopathology; D010614:Pharynx / Q000601:surgery; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D016896:Treatment Outcome; D014609:Uvula / Q000601:surgery