title: Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa.
abstract: Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: William P
authors.initials: WP
authors.lastname: Jones
authors.forename: Qiuwen
authors.initials: Q
authors.lastname: Mi
authors.forename: Ismail
authors.initials: I
authors.lastname: Rachman
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: John M
authors.initials: JM
authors.lastname: Cassady
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D018515:Plant Leaves / Q000737:chemistry*; D029648:Verbenaceae / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; C514657:premnone A; C514658:premnone B; C514659:premnone C