title: [C-reactive protein in severe combined trauma not complicated and complicated by sepsis].
abstract: The role of C-reactive protein (CRP) was studied in the development of nonbacterial systemic inflammation response, infectious complications, severe sepsis in severe combined trauma. It was shown that daily quantitative indicators of CRP in blood of patients in the intensive care unit allowed prognosis of the development of nonbacterial systemic inflammation response, infectious complications and sepsis. The CRP level >40 mg/l in the first day under conditions of not using glucocorticoids manifests a risk of the development of infectious complications. Prolonged reduction of CRP from the 3rd day is characteristic of a favorable course of trauma disease, maintenance of the level or its elevation - of pyo-infectious complications. With the following development of sepsis CRP in blood during the first week is higher than 120 mg/l. The nonbacterial systemic inflammation response is determined on the 2nd day after trauma in 14.8% of casualties not being followed by the development of septic complications and in 44.5% - followed by sepsis. Glucocorticoids and specific immune medicines used in treatment of sepsis result in a reduced amount or complete disappearance of CRP in blood during administration of these medicines. Rejection of them is followed by the appearance of CRP in the amount showing the effect of treatment. Gradual reduction of CRP in sepsis associated with decreased activity of the infectious processes was observed only in casualties without a polyorganic insufficiency.
authors.forename: E K
authors.initials: EK
authors.lastname: Gumanenko
authors.forename: N S
authors.initials: NS
authors.lastname: Nemchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Boiarintsev
authors.forename: A V
authors.initials: AV
authors.lastname: Nikiforenko
authors.forename: A N
authors.initials: AN
authors.lastname: Pavlenko
authors.forename: A A
authors.initials: AA
authors.lastname: Rud'
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D001930:Brain Injuries / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011008:Pneumococcal Infections / Q000150:complications / Q000453:epidemiology; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000453:epidemiology; D014947:Wounds and Injuries / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*
chemical_list: D002097:C-Reactive Protein