title: Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia.
abstract: Three flat-coated retrievers with a regenerative anaemia were examined. They were hypoproteinaemic suggesting that the anaemia might be due to blood loss, but it was not possible to identify a site of haemorrhage. All three had splenomegaly with splenic abnormalities apparent on ultrasonography. Ultimately all three animals were shown to have a histiocytic sarcoma involving the spleen and other tissues. A fourth flat-coated retriever with anaemia, hypoproteinaemia and an abdominal mass was also diagnosed with a histiocytic sarcoma of the spleen following splenectomy. It is postulated that the dogs' anaemia was due to erythrophagocytosis, either directly by neoplastic cells or by reactive macrophages.
authors.affiliation: Department of Clinical Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
authors.forename: J
authors.initials: J
authors.lastname: Dobson
authors.forename: E
authors.initials: E
authors.lastname: Villiers
authors.forename: A
authors.initials: A
authors.lastname: Roulois
authors.forename: S
authors.initials: S
authors.lastname: Gould
authors.forename: P
authors.initials: P
authors.lastname: Mellor
authors.forename: T
authors.initials: T
authors.lastname: Hoather
authors.forename: P
authors.initials: P
authors.lastname: Watson
mesh_terms: D000740:Anemia / Q000209:etiology*; D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D054747:Histiocytic Sarcoma / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D007019:Hypoproteinemia / Q000209:etiology*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D011379:Prognosis; D013156:Splenectomy / Q000662:veterinary; D013160:Splenic Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000662:veterinary*