title: In vivo antitumor activity of chitosan nanoparticles.
abstract: Chitosan nanoparticles have been synthesized as potential anticancer agents, and evaluated, in vitro, against various cancer cell lines. In this study, in vivo antitumor activity of chitosan nanoparticles against Sarcoma-180 and mouse hepatoma H22 was investigated. Chitosan nanoparticles showed significant antitumor activity in vivo. The doses and particle size made a great effect on their efficacy.
authors.affiliation: Zhejiang University, Nano-Biology Lab of Animal Science College, Hangzhou, PR China. lifengq01@hotmail.com
authors.forename: Lifeng
authors.initials: L
authors.lastname: Qi
authors.forename: Zirong
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D048271:Chitosan