title: Longterm survival of a Western patient with metastatic gastric cancer treated with S-1 plus cisplatin.
abstract: The prognosis for patients with metastatic gastric cancer is poor. Fewer than 10% of patients with metastatic gastric cancer live beyond 2 years. Chemotherapy is offered with a palliative intent. We report the case of a Western patient with metastatic gastric cancer successfully treated with S-1 plus cisplatin. S-1 was administered orally every 12 h at a dose of 30 mg/m2 (60 mg/m2 daily) for 21 consecutive days, followed by 7 days of recovery. Cisplatin was administered intravenously on day 1, at a dose of 60 mg/m2. The cycles were repeated every 28 days. The patient first received seven cycles of S-1 plus cisplatin; however, cisplatin was discontinued secondary to nephrotoxicity, and S-1 was administered alone for an additional five cycles. The patient achieved a clinical complete response to S-1 plus cisplatin. The complete response has now been maintained for 12 months without any chemotherapy. A total of 28 months have elapsed since the date of registration on the study and the patient currently has no symptoms. This patient exemplifies the strategy of maintenance therapy with S-1 alone and shows a prolonged and excellent response to S-1 and cisplatin.
authors.affiliation: Department of Gastrointestinal Medical Oncology, Box 426, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Tetzlaff
authors.forename: Josephine
authors.initials: J
authors.lastname: Faust
authors.forename: Jaffer A
authors.initials: JA
authors.lastname: Ajani
mesh_terms: D001741:Black or African American; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality*; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage; D013995:Time
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin