Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid.
In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reduced cytotoxicity and effective apoptosis when comparing with the native polyamide.
Liu
Yi
Y
Department of Applied Chemistry, Beijing Institute of Technology, 100081 Beijing, China.
Deng
Yulin
Y
Zheng
Rong
R
Zhang
Peilong
P
Zhai
Hui
H
Zhu
Changjin
C
D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D009757:Nylons / Q000378:metabolism* / Q000633:toxicity*; D010743:Phospholipids / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D009757:Nylons; D010743:Phospholipids; D004247:DNA