title: Sesame oil use in ameliorating cough in children: a randomised controlled trial.
abstract: OBJECTIVE
  To examine the role of sesame oil (SO) in reducing the frequency and severity of acute cough in children 2-12 years of age.
  
  
  METHODS
  Double blind, placebo controlled randomised trial.
  
  
  METHODS
  Seven primary health care centres/clinics in Lebanon. A total of 107 children between the age of 2 and 12 years with cough secondary to common cold were enrolled.
  
  
  METHODS
  Five milliliters of SO or placebo by mouth at bed time.
  
  
  METHODS
  Cough strength and frequency as judged by parents on a four points Likert scale after giving three syrup doses over three consecutive nights. Analysis was performed on an intention to treat basis.
  
  
  RESULTS
  At day 1, the effect size for cough frequency and cough strength were +0.26 (95%CI -0.64,+0.12) and +0.15 (95%CI -0.53, +0.23), respectively. SO decreased cough symptoms more than placebo but these were not statistically significant. The effect size decreased from days 1 to 3. Cough symptoms improved over the 3 days both in SO and placebo group. No evidence of undesirable effects were noted to SO.
  
  
  CONCLUSIONS
  Like other over the counter antitussives, SO did not result in marked improvement in cough symptoms.
authors.affiliation: American University of Beirut, Department of Pharmacology and Therapeutics, P.O. Box 113-6044, Beirut, Lebanon. brsaab@aub.edu.lb
authors.forename: Bassem-Roberto
authors.initials: BR
authors.lastname: Saab
authors.forename: Nora
authors.initials: N
authors.lastname: Pashayan
authors.forename: Souheil
authors.initials: S
authors.lastname: El-Chemaly
authors.forename: Ramzi
authors.initials: R
authors.lastname: Sabra
mesh_terms: D002648:Child; D002675:Child, Preschool; D003139:Common Cold / Q000150:complications*; D003371:Cough / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy; D012715:Sesame Oil / Q000627:therapeutic use*; D031685:Sesamum
chemical_list: D012715:Sesame Oil