Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery.
To better control drug delivery rate, a simple and effective approach has been developed for controlled drug delivery carrier system through one-step surface modification of the ibuprofen-impregnated silica MCM-41 with 1, 1, 1, 3, 3, 3-hexamethyldisilazane (HMDS). The 29Si MAS NMR characterization demonstrated that different contents of trimethylsilyl (TMS) groups were successfully grafted onto the samples modified with different silylation times. The results obtained from in vitro tests exhibited that the introduction of TMS groups greatly retarded the ibuprofen release rate. Even after in vitro test for 48 h, only 75% of the impregnated ibuprofen could be released from the modified sample with TMS groups content of 14.5% (related to the total silicon atoms). However, the release of ibuprofen could be completed just after about 1 h from the pure silica MCM-41 under the same release conditions. Furthermore, the release rate of ibuprofen could be well modulated by changing the grafted content of TMS groups, and was found to decrease with increasing grafted amount of TMS groups.
Tang
Qunli
Q
State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, 030001, PR China. tangqunli2003@hotmail.com
Xu
Yao
Y
Wu
Dong
D
Sun
Yuhan
Y
Wang
Jiqing
J
Xu
Jun
J
Deng
Feng
F
D001682:Biological Availability; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D017646:Organosilicon Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D013818:Thermogravimetry; D014297:Trimethylsilyl Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction
D003692:Delayed-Action Preparations; D004337:Drug Carriers; C509968:MCM-41; D017646:Organosilicon Compounds; D014297:Trimethylsilyl Compounds; D012822:Silicon Dioxide; C024548:hexamethylsilazane; D007052:Ibuprofen