The effects of droperidol in perforating keratoplasty.
OBJECTIVE
To evaluate the intraoperative and postoperative effects of droperidol administered with general anesthesia during perforating keratoplasty.


METHODS
A prospective, randomized, double-masked clinical trial. Twenty-seven patients undergoing penetrating keratoplasty under general anesthesia were included. Patients were assigned randomly to two groups. Fifteen subjects received droperidol during induction of general anesthesia. Twelve control patients received general anesthesia without droperidol.


RESULTS
Droperidol significantly reduced fellow eye intraocular pressure (p < 0.0001). Intraoperative anterior chamber depth was significantly deeper with droperidol (p = 0.0002). Iris bulging was observed in 25% of the control group and 0% with droperidol. There was significantly less postoperative nausea in the droperidol group (p = 0.038). There was less postoperative vomiting in the droperidol group, although the difference was not significant (p = 0.07). Postoperative wound gaping was observed in 2 patients; both of them did not receive droperidol.


CONCLUSIONS
Droperidol effectively reduces intraoperative and postoperative complications in keratoplasty surgery.
Garzozi
Hanna J
HJ
Departments of Ophthalmology and Anesthesiology, Bnai Zion Medical Center, Rappaport Faculty of Medicine Technion, Haifa, Israel. garzozi@yahoo.com
Shehadeh-Masha'our
Raneen
R
Somri
Mostafa
M
Kagemann
Larry
L
Harris
Alon
A
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General / Q000379:methods*; D000867:Anterior Chamber / Q000187:drug effects* / Q000473:pathology; D002648:Child; D003316:Corneal Diseases / Q000601:surgery; D004311:Double-Blind Method; D004329:Droperidol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D007432:Intraoperative Period; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome
D000759:Adjuvants, Anesthesia; D004329:Droperidol