Radiological-pathological correlation in lipoblastoma and lipoblastomatosis.
BACKGROUND
Lipoblastoma and lipoblastomatosis are uncommon benign mesenchymal lesions that predominantly occur in infancy and early childhood.


OBJECTIVE
To evaluate the imaging and histological features of lipoblastoma and lipoblastomatosis.


METHODS
Retrospective review of the radiological and pathological findings in children with lipoblastoma and lipoblastomatosis treated at a single centre between 1997 and 2004.


RESULTS
Eight children (median age 18 months) had undergone imaging and surgery at our institution. An infiltrative growth pattern was identified at imaging in two children with lipoblastomatosis, and a well-defined mass in six children with lipoblastoma. In all patients, imaging showed a lesion composed mostly, but not entirely, of fat. There were no recurrences at follow-up of between 1 and 91 months.


CONCLUSIONS
In infancy and early childhood, the identification of a tumour composed mostly of fat should suggest the diagnosis of lipoblastoma or lipoblastomatosis.
Moholkar
Shruti
S
Department of Radiology, Great Ormond Street Hospital, London, WC1N 3JH, UK.
Sebire
Neil J
NJ
Roebuck
Derek J
DJ
D001132:Arm / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008067:Lipoma / Q000175:diagnosis* / Q000473:pathology; D008068:Lipomatosis / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008482:Mediastinum / Q000473:pathology; D009852:Omentum / Q000000981:diagnostic imaging / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013131:Spine / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography