[Time distribution of ventricular arrhythmias in patients with Brugada syndrome].
OBJECTIVE
To study the characterization of time distribution of ventricular arrhythmias in patients with Brugada syndrome (BrS) using Holter monitoring and ICD follow-up.


METHODS
Patients with BrS [all male, mean age (41.07 +/- 11.49) years], were divided into ventricular fibrillation (VF) group (n = 7) and no ventricular fibrillation (N-VF) group (n = 7). Premature ventricular capture (PVC) and VF episodes were detected by Holter monitoring and ICD recording.


RESULTS
The 24 hours total number of PVCs ranged from 0 to 74 (mean 9.61 +/- 17.23) in most of the patients and were similar between VF group and N-VF group. The percentage of PVC episodes in VF group was significantly higher than that in N-VF group from nocturnal time to early morning (22:00 to 7:00, 98.67% vs. 44.14%, P < 0.01). There were total 75 VF episodes during (23.18 +/- 17.96) months' follow-up in 5 patients with BrS, 93.3% of which occurred from nocturnal time to early morning (22:00 to 7:00).


CONCLUSIONS
The episodes of PVC were enriched from nocturnal time to early morning in BrS patients, this time distribution could be a new noninvasive risk stratification factor for BrS. The episodes of VF in BrS patients were also enriched from nocturnal time to early morning and this time characteristic of episodes of VF could be used to guide drug therapy.
Yang
Bing
B
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Cao
Ke-jiang
KJ
Shan
Qi-jun
QJ
Xia
Yun
Y
Tu
Jing
J
Chen
Ming-long
ML
Zou
Jian-gang
JG
Xu
Dong-jie
DJ
Li
Ku-lin
KL
Chen
Chun
C
D000328:Adult; D053840:Brugada Syndrome / Q000150:complications / Q000503:physiopathology*; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013995:Time; D014693:Ventricular Fibrillation / Q000209:etiology*