A new approach to phospholipid synthesis using tetrahydropyranyl glycerol: rapid access to phosphatidic acid and phosphatidylcholine, including mixed-chain glycerophospholipid derivatives.
A new synthesis of phosphatidic acid and phosphatidylcholine is reported, relying on the preparation of 3-tetrahydropyranyl-sn-glycerol as the key intermediate for sequential introduction of the primary and secondary acyl functions to produce chiral diglycerides that are phosphorylated to obtain the target phospholipid compounds.
Rosseto
Renato
R
Department of Chemistry and Biochemistry, California State University, Northridge, 91330-8262, USA.
Bibak
Niloufar
N
Hajdu
Joseph
J
D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D020404:Glycerophospholipids / Q000138:chemical synthesis*; D010712:Phosphatidic Acids / Q000138:chemical synthesis*; D010713:Phosphatidylcholines / Q000138:chemical synthesis*; D010743:Phospholipids / Q000138:chemical synthesis*; D010766:Phosphorylation
D020404:Glycerophospholipids; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D005990:Glycerol