Cardiopulmonary impairment in young women with polycystic ovary syndrome.
BACKGROUND
Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO(2max)). At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed.


OBJECTIVE
Our objective was to assess cardiopulmonary functional capacity in young PCOS overweight patients.


METHODS
We conducted a prospective baseline-controlled clinical study at University Federico II of Naples, School of Medicine (Naples, Italy).


METHODS
Forty-five PCOS patients were matched with 45 healthy women for age (mean +/- sd, 21.3 +/- 2.0 vs. 21.6 +/- 1.9 yr, respectively) and body mass index (29.4 +/- 3.6 vs. 29.0 +/- 3.4 kg/m(2), respectively).


METHODS
We assessed hormonal and metabolic pattern and functional capacity by cardiopulmonary exercise testing to evaluate maximal oxygen consumption (VO(2max)), oxygen consumption at anaerobic threshold (VO(2AT)), and the maximal workload at peak exercise.


RESULTS
VO(2max) (17.0 +/- 3.7 vs. 26.8 +/- 3.5 ml/kg.min), oxygen consumption at anaerobic threshold (13.9 +/- 3.0 vs. 21.2 +/- 3.8 ml/kg.min), and maximal workload at peak exercise (101.3 +/- 25.2 vs. 135 +/- 22.6 W) were significantly (P < 0.001) reduced in PCOS subjects compared with healthy women. The multiple linear regression analysis showed that only homeostasis model assessment appears to have a strong negative linear relation with VO(2max) in PCOS. No relation was found in controls.


CONCLUSIONS
Our data demonstrate a reduced cardiopulmonary functional capacity in young PCOS patients.
Orio
Francesco
F
Department of Molecular, Clinical Endocrinology, and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. francescoorio@virgilio.it
Giallauria
Francesco
F
Palomba
Stefano
S
Cascella
Teresa
T
Manguso
Francesco
F
Vuolo
Laura
L
Russo
Tiziana
T
Tolino
Achille
A
Lombardi
Gaetano
G
Colao
Annamaria
A
Vigorito
Carlo
C
D000328:Adult; D015308:Anaerobic Threshold; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005080:Exercise Test; D005215:Fasting; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D010101:Oxygen Consumption; D005082:Physical Exertion; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011446:Prospective Studies
D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein