title: Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes.
abstract: The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(O iPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfully applied this methodology to the difluoromethylation of aldehydes using Me3SiCF2SePh, Me3SiCF2P(O)OEt2 and Me3SiCF2SPh.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuta
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ogawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Toru