title: Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector.
abstract: This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-6.0 [corrected] mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
authors.affiliation: Shandong Province Key Laboratory for Applied Technology of Sophisticated Analytical Instruments, Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong 250014, People's Republic of China. xia-w21cn0@163.com
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Yuan
authors.forename: Chuange
authors.initials: C
authors.lastname: Cheng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.forename: Junbo
authors.initials: J
authors.lastname: Shi
authors.forename: Rusong
authors.initials: R
authors.lastname: Zhao
mesh_terms: D002849:Chromatography, Gas / Q000379:methods* / Q000592:standards; D004340:Drug Contamination; D005410:Flame Ionization / Q000379:methods* / Q000592:standards; D008832:Microchemistry / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012997:Solvents / Q000032:analysis*; D014835:Volatilization
chemical_list: D004364:Pharmaceutical Preparations; D012997:Solvents