title: Cost-effectiveness of peginterferon alfa-2a (40kDa) plus ribavirin in patients with HIV and hepatitis C virus co-infection.
abstract: BACKGROUND
  A multinational trial (APRICOT) showed that peginterferon alfa-2a (40kDa) plus ribavirin is efficacious for treatment of HIV-HCV co-infection. The cost-effectiveness of treating these patients with peginterferon alfa-2a/ribavirin has yet to be explored from a US societal perspective.
  
  
  OBJECTIVE
  To predict the cost-effectiveness of peginterferon alfa-2a/ribavirin with interferon/ribavirin (IFN/RBV) or no treatment in HIV-HCV co-infected patients.
  
  
  METHODS
  A Markov model was constructed with liver progression estimates based on published literature. Sustained virological response and baseline characteristics of the reference case were based on APRICOT. Quality of life and costs in 2004 US dollars (US$) were based on literature estimates and discounted at 3%.
  
  
  RESULTS
  Peginterferon alfa-2a/ribavirin compared with IFN/RBV or no treatment is predicted to increase quality-adjusted life-years (QALYs) by 0.73 and 0.94 years, respectively, in HCV-genotype-1 patients. The incremental cost-effectiveness ratio of peginterferon alfa-2a/ribavirin compared with IFN/RBV and no treatment for all patients is respectively US$ 2,082 and 5,187/QALY gained.
  
  
  CONCLUSIONS
  Anti-HCV treatment is predicted to decrease the risk of cirrhosis and increase quality-adjusted survival of HIV-HCV co-infected patients compared with IFN/RBV and no treatment. Peginterferon alfa-2a/ribavirin's cost per QALY gained relative to these options falls within the cost-effectiveness level of many health technologies commonly adopted in the US.
authors.affiliation: The SPHERE Institute/Acumen, LLC, Burlingame, CA 94010, USA. jhornberger@sphereinstitute.org
authors.forename: John
authors.initials: J
authors.lastname: Hornberger
authors.forename: Francesca J
authors.initials: FJ
authors.lastname: Torriani
authors.forename: Douglas T
authors.initials: DT
authors.lastname: Dieterich
authors.forename: Norbert
authors.initials: N
authors.lastname: Bräu
authors.forename: Mark S
authors.initials: MS
authors.lastname: Sulkowski
authors.forename: Maribel Rodriguez
authors.initials: MR
authors.lastname: Torres
authors.forename: Jesse
authors.initials: J
authors.lastname: Green
authors.forename: Kavita
authors.initials: K
authors.lastname: Patel
mesh_terms: D017677:Age Distribution; D000998:Antiviral Agents / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications*; D017048:Health Care Costs; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000191:economics / Q000453:epidemiology / Q000821:virology; D008297:Male; D008390:Markov Chains; D018803:Models, Economic; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage / Q000191:economics* / Q000627:therapeutic use; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a