[A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining].
A 52-year-old house wife presented with pain on urination. Cystoscopy and magnetic resonance imaging revealed solid and sessile tumor of 3 cm in diameter invading the bladder wall. Pathological examination of the transurethral resection specimen showed proliferation of spindle cells and epithelial cells. Since both types of cells were positive for cytokeratin immunostaining, sarcomatoid carcinoma was highly suspected. She underwent anterior pelvic exenteration and construction of continent reservoir (Penn Pouch). Since the tumor cells showed spindle cell proliferation alone without epithelial growth and positive staining for anaplastic lymphoma kinase, we corrected the final diagnosis as an inflammatory myofibroblastic tumor of the urinary bladder. She has been doing well without recurrence for 1 year.
Takeshita
Hideki
H
Department of Urology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research.
Kawakami
Satoru
S
Okubo
Yuhei
Y
Yamamoto
Shinya
S
Yonese
Junji
J
Fukui
Iwao
I
Kono
Atsushi
A
Kurata
Morito
M
Inoshita
Naoko
N
Ishikawa
Yuichi
Y
D000077548:Anaplastic Lymphoma Kinase; D003558:Cystoscopy; D003937:Diagnosis, Differential; D005260:Female; D006104:Granuloma, Plasma Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010385:Pelvic Exenteration; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D020794:Receptor Protein-Tyrosine Kinases; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery
C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases