title: Why aging T cells fail: implications for vaccination.
abstract: The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly.
authors.affiliation: Trudeau Institute, Inc., Saranac Lake, New York 12983.
authors.forename: Laura
authors.initials: L
authors.lastname: Haynes
authors.affiliation: Trudeau Institute, Inc., Saranac Lake, New York 12983. Electronic address: sswain@northnet.org.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Swain
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000375:Aging / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic