An experimental model for the treatment of lethal bleeding injury to the juxtahepatic vena cava with stent graft.
BACKGROUND
Juxtahepatic vein injuries present a high mortality rate. Our objectives were to develop an experimental model of endovascular lethal injury of the juxtahepatic inferior vena cava (JHIVC) and to evaluate its hemodynamic alterations; to treat the lesion with volume replacement, and a stent graft (SG); and to follow the animals after treatment.


METHODS
Twenty dogs were anesthetized and monitored [heart rate (HR), mean arterial pressure (MAP), vesical and peritoneal pressures], and submitted to a JHIVC endovascular injury. After volume replacement the dogs were divided into two groups: control (GI) and experimental (GII). GI was observed until death. GII was treated with SG and followed by Doppler ultrasound (DUS) and cavography for 4 (GIIA), and 8 weeks (GIIB), and then sacrificed and IVC and SG were analyzed.


RESULTS
GI presented increased abdominal pressures, arterial hypotension, and death after 80 minutes. GII had a 100% survival rate till sacrifice, without clinical repercussions. At DUS and cavography all SG were patent, with monophasic pulsatile flow. On US, SG diameters after 2, 4, and 8 weeks did not show differences. On cavography IVC diameters presented no difference between groups GIIA and GIIB throughout the experiment. These data analyzed for the GII as a whole, showed statistically significant differences. Average lumen diameter reduction of SG was 27.43+/-20,00%. Pressure values in the IVC cranially, caudally to the SG, and inside the SG, did not show differences. In the IVC with the SG we observed a thicker neointima layer, and the injury in the media layer was covered with fibroconnective tissue.


CONCLUSIONS
We developed an experimental dog model of endovascular lethal injury of the JHIVC with significant increase in abdominal pressures, and a mortality rate of 100%. The treatment of this lesion with SG resulted in a thickened neointima layer, and a 27% reduction in the JHIVC lumen diameter, without clinical repercussion, and with a 100% survival rate.
Porta
Rina Maria Pereira
RM
Radiology Service, , Discipline of Trauma Surgery, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, SP, Brazil. rinaporta@uol.com.br
Poggetti
Renato Sérgio
RS
Pereira
Osvaldo
O
Chammas
Cristina
C
Fontes
Belchor
B
Fratezi
Ayrton
A
Birolini
Dario
D
D000704:Analysis of Variance; D017130:Angioplasty; D000818:Animals; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D004285:Dogs; D005440:Fluid Therapy; D008099:Liver / Q000098:blood supply*; D008297:Male; D012771:Shock, Hemorrhagic / Q000601:surgery* / Q000628:therapy; D015607:Stents; D017539:Tunica Intima / Q000473:pathology; D018608:Ultrasonography, Doppler; D014682:Vena Cava, Inferior / Q000293:injuries* / Q000473:pathology