title: S100A13, a new marker of angiogenesis in human astrocytic gliomas.
abstract: S100 proteins are Ca(2+)-binding polypeptides involved in the tumourigenesis of several human neoplasms. S100A13 is a key regulator of the stress-dependent release of FGF1, the prototype of the FGF protein family involved in angiogenesis. Indeed, S100A13 is a copper binding protein able to enhance the export of FGF1 in response to stress in vitro and to induce the formation of a multiprotein aggregate responsible for FGF1 release. We investigated the expression of S100A13 in human astrocytic gliomas in relation to tumour grading and vascularization. A series of 26 astrocytic gliomas was studied to evaluate microvessel density and to assess FGF1, S100A13 and VEGF-A expression. FGF1 was equally expressed in the vast majority of tumours, whereas S100A13 and VEGF-A were significantly up-regulated in high-grade vascularized gliomas. Moreover, both S100A13 and VEGF-A expression significantly correlated with microvessel density and tumour grading. These data suggest that the up-regulation of S100A13 and VEGF-A expression correlates with the activation of angiogenesis in high-grade human astrocytic gliomas.
authors.affiliation: Clinical Oncology Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Landriscina
authors.forename: G
authors.initials: G
authors.lastname: Schinzari
authors.forename: G
authors.initials: G
authors.lastname: Di Leonardo
authors.forename: M
authors.initials: M
authors.lastname: Quirino
authors.forename: A
authors.initials: A
authors.lastname: Cassano
authors.forename: E
authors.initials: E
authors.lastname: D'Argento
authors.forename: L
authors.initials: L
authors.lastname: Lauriola
authors.forename: M
authors.initials: M
authors.lastname: Scerrati
authors.forename: I
authors.initials: I
authors.lastname: Prudovsky
authors.forename: C
authors.initials: C
authors.lastname: Barone
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000098:blood supply* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; C511523:S100A13 protein, human; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors