In renal transplanted patients inflammation and oxidative stress are interrelated.
BACKGROUND
The inflammatory state plays a well-documented role to cause oxidative stress, especially in end-stage renal disease (ESRD) patients, wherein several cardiovascular risk factors are amplified by the coexistence of a microinflammatory state with increased oxidative stress.


METHODS
We measured serum concentrations of high sensitivity C-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha), 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha-in vivo oxidative stress marker) in 15 chronic renal failure (CRF) and 15 transplant patients versus 15 healthy controls. Exclusion criteria were: age <30 or >65 years as well as a diagnosis of diabetes or cardiovascular diseases. We evaluated systolic (SBP) and diastolic blood pressure (DBP), serum creatinine (sCr), and glomerular filtration rate (GFR).


RESULTS
Both the transplanted and the CRF group showed significantly higher values of CRP, TNFalpha, and 8-iso-PGF2alpha than the controls (P < .05 for all). SBP, DBP, and sCr were not different between transplanted and CRF patients. CRP was higher in transplant recipients than in CRF patients (P < .05). No difference in TNFalpha levels was observed between the two groups. 8-iso-PGF2alpha was significantly higher in the CRF than in the transplanted group (P < .05), although the latter cohort showed a positive correlation between 8-iso-PGF2alpha and TNFalpha (P < .001), sCr (P < .001), SBP (P < .05), and DBP (P < .05). In the same group both 8-iso-PGF2alpha and TNFalpha were negatively correlated with GFR (r -.824 and -.866, respectively; P < .001 for both).


CONCLUSIONS
We observed the coexistence of increased oxidative stress and an inflammatory state among renal graft recipients.
Cottone
S
S
Università di Palermo, Italy, Cattedra di Medicina Interna, Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Divisione di Medicina Interna, Nefrologia ed Ipertensione, Palermo, Italy. sancott@tin.it
Palermo
A
A
Vaccaro
F
F
Raspanti
F
F
Buscemi
B
B
Incalcaterra
F
F
Cerasola
G
G
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002102:Cadaver; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000097:blood; D007558:Italy; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D014019:Tissue Donors; D044465:White People
D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein