title: neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities.
abstract: Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China. daishengjun_9@hotmail.com
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Tao
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Yong-Tao
authors.initials: YT
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Shen
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031363:Scutellaria / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D045785:Diterpenes, Clerodane