In vivo antitumor activity of chitosan nanoparticles.
Chitosan nanoparticles have been synthesized as potential anticancer agents, and evaluated, in vitro, against various cancer cell lines. In this study, in vivo antitumor activity of chitosan nanoparticles against Sarcoma-180 and mouse hepatoma H22 was investigated. Chitosan nanoparticles showed significant antitumor activity in vivo. The doses and particle size made a great effect on their efficacy.
Qi
Lifeng
L
Zhejiang University, Nano-Biology Lab of Animal Science College, Hangzhou, PR China. lifengq01@hotmail.com
Xu
Zirong
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D013997:Time Factors
D000970:Antineoplastic Agents; D048271:Chitosan