title: Induction of differentiation in leukemic cell strains with myelopeptide-4.
abstract: We studied the capacity of myelopeptide-4 (regulatory peptide of the bone marrow origin) to induce terminal differentiation of HL-60 and K-562 leukemic cells. Myelopeptide-4 increased the expression of CD14 and CD38 differentiation antigens on the surface of HL-60 cells and of CD44 antigen on K-562 cells, induced the appearance of mature monocyte/macrophages in HL-60 culture and hemoglobin-producing cells in K-562 cell culture, and stimulated phagocytic activity of THP-1 leukemic cells. Myelopeptide-4 is an endogenous factor of cell differentiation, a prospective agent for antileukemic therapy.
authors.affiliation: M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Kirilina
authors.forename: N I
authors.initials: NI
authors.lastname: Suvorov
authors.forename: S S
authors.initials: SS
authors.lastname: Popova
authors.forename: S V
authors.initials: SV
authors.lastname: Khaidukov
authors.forename: E M
authors.initials: EM
authors.lastname: Rapoport
authors.forename: L A
authors.initials: LA
authors.lastname: Fonina
authors.forename: A A
authors.initials: AA
authors.lastname: Mikhailova
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000096:biosynthesis; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D018922:HL-60 Cells; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis; D020014:K562 Cells; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology*; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D009842:Oligopeptides / Q000378:metabolism*; D010587:Phagocytosis
chemical_list: D006454:Hemoglobins; D018960:Hyaluronan Receptors; D018950:Lipopolysaccharide Receptors; D009842:Oligopeptides; C502954:phenylalanyl-arginyl-prolyl-arginyl-isoleucyl-methionyl-threonyl-proline; D051997:ADP-ribosyl Cyclase 1