title: Maternal serum and amniotic fluid inhibin A levels in women who subsequently develop severe preeclampsia.
abstract: The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia.
authors.affiliation: Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Hyun-Mee
authors.initials: HM
authors.lastname: Ryu
authors.forename: Jae-Hyug
authors.initials: JH
authors.lastname: Yang
authors.forename: Moon-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyun-Kyong
authors.initials: HK
authors.lastname: Ahn
authors.forename: Joong-Sik
authors.initials: JS
authors.lastname: Shin
authors.forename: Jun-Seek
authors.initials: JS
authors.lastname: Choi
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Jin-Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Bom-Yi
authors.initials: BY
authors.lastname: Lee
authors.forename: Do-Jin
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007265:Inhibins / Q000096:biosynthesis* / Q000097:blood*; D008423:Maternal Age; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012307:Risk Factors
chemical_list: C422362:inhibin A; D007265:Inhibins