title: Association between severity of inflammation in CNS and development of sunset glow fundus in Vogt-Koyanagi-Harada disease.
abstract: OBJECTIVE
  To investigate the association between central nervous system (CNS) inflammation at disease onset and the appearance of sunset glow fundus (SGF) in Vogt-Koyanagi-Harada (VKH) disease.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Charts of 102 patients with VKH disease followed from from initial onset were reviewed. The frequency of cerebrospinal fluid (CSF) pleocytosis and the number of cells in the CSF were compared among the patients who eventually developed SGF and the patients who had not developed SGF as of final follow-up.
  
  
  RESULTS
  SGF was observed in 69 (67.6%) of 102 patients. The frequency of CSF pleocytosis was 77 (82.7%) of 93 patients examined. The frequency of CSF pleocytosis and the number of cells in CSF were significantly higher in patients who eventually developed SGF (both P = .0029).
  
  
  CONCLUSIONS
  Severe inflammatory response in CNS sites at disease onset may influence the development of SGF in VKH disease.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Japan. hirojunharu@aol.com
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Keino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Usui
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015862:Choroid Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000134:cerebrospinal fluid; D008297:Male; D008580:Meningism / Q000150:complications; D008582:Meningitis, Aseptic / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D014012:Tinnitus / Q000150:complications; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000175:diagnosis