[The problem of induced genome instability as the basis of the increased morbidity in children exposed to low-intensity radiation at low doses].
The main results of the complex examination of the genome instability are presented in children constantly living on territories contaminated with radionuclides as a result of the accident at the CNPP (Novozybkov district, Bryansk region, 16-18 Ci/km2, 137Cs) and in children exposed to low-intensity radiation at different stages of ontogenetic development: children exposed to postnatal irradiation in 1986 (born before the accident), children exposed to intrauterine irradiation during the accident in 1986, children of irradiated parents born after the accident in 1987-1992 and in 1994-2000. In all examined groups of irradiated children increased frequencies of certain radiation-induced chromosome aberrations were observed as well as a reduced activity of unscheduled synthesis of genomic DNA in lymphocytes and peculiarities in individual heterozygosity of genes encoding structural and enzymatic proteins of blood. An increased radiosensitivity of lymphocyte genomes to testing in vitro irradiation and peculiarities in the dynamics of the frequencies of chromosome aberrations and sister chromatid exchanges in 3 cell generations were revealed in children from the contaminated areas. The data obtained suggest a systemic character of dysgenomic effects, the reality of induction of genome instability in the growing organism of children exposed to low-intensity radiation at low doses the expression of which is determined by individual genotypic features of the organism. Biological significance of the phenomenon of the post-radiation genome instability, its relation to the state of health and the pathogenetic role in the development of somatic pathology are postulated.
Suskov
I I
II
Kuz'mina
N S
NS
Suskova
V S
VS
Baleva
L S
LS
Sipiagina
A E
AE
D000293:Adolescent; D001798:Blood Proteins / Q000187:drug effects / Q000235:genetics; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D004194:Disease / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D005260:Female; D042822:Genomic Instability; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects; D008297:Male; D018811:Maternal Exposure; D009017:Morbidity; D018812:Paternal Exposure; D011210:Power Plants; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D018788:Radioactive Hazard Release; D012426:Russia / Q000453:epidemiology; D012990:Soil Pollutants, Radioactive; D014455:Ukraine
D001798:Blood Proteins; D012990:Soil Pollutants, Radioactive; D004247:DNA