title: Functional and isokinetic assessment of muscle strength in patients with idiopathic inflammatory myopathies.
abstract: OBJECTIVE
  To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing.
  
  
  METHODS
  Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system used to assess Duchenne dystrophy, (ii) the four-stage grading system of Henriksson and Sandstedt, (iii) an isokinetic muscle strength test (Kin Com, Chatanooga) and (iv) the Health Assessment Questionnaire (HAQ).
  
  
  RESULTS
  The neuromuscular scales showed normal or only mildly impaired muscle strength in 60% (Duchenne scale) and 80% (Henriksson and Sandstedt scale) of the patients, respectively, whereas isokinetic testing detected moderate to severe reductions in muscle strength in almost 70% of the patients. No correlations were observed between muscle strength and disease activity, therapy, age at evaluation and disease duration. There was a correlation between the results of the HAQ and neuromuscular testing, but not the isokinetic test.
  
  
  CONCLUSIONS
  Although less easy and more expensive to administer, isokinetic testing appears to be a more sensitive instrument than the standard neuromuscular tests for assessing muscle function in IIM patients. In particular, it can detect small reductions in muscle strength.
authors.affiliation: University of Pisa, Rheumatology Unit, Department of Internal Medicine, Italy. marta.mosca@int.med.unip.it
authors.forename: R
authors.initials: R
authors.lastname: Neri
authors.forename: M
authors.initials: M
authors.lastname: Mosca
authors.forename: G
authors.initials: G
authors.lastname: Stampacchia
authors.forename: E
authors.initials: E
authors.lastname: Vesprini
authors.forename: A
authors.initials: A
authors.lastname: Tavoni
authors.forename: A
authors.initials: A
authors.lastname: d'Ascanio
authors.forename: S
authors.initials: S
authors.lastname: Bombardieri
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009220:Myositis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents