title: Positive association of serum levels of advanced glycation end products with thrombogenic markers in humans.
abstract: Advanced glycation end products (AGEs) are elevated in diabetes. We have demonstrated that AGEs trigger thrombogenic responses in cultured cells. We investigated here whether serum AGE levels were positively correlated with thrombogenic markers in humans. Data for fasting serum AGE levels of 186 nondiabetic subjects were obtained from a general population in Japan. We measured body mass index, blood pressure, total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol, triglycerides, fasting plasma glucose, glycosylated hemoglobin A(1c), insulin, creatinine, uric acid, high-sensitive C-reactive protein, plasminogen activator inhibitor 1 (PAI-1), and fibrinogen. Uni- and multivariate analyses were applied for the determinants of serum AGE levels. The average AGE levels were 4.11 +/- 0.74 U/mL in males and 4.10 +/- 0.93 U/mL in females. In the univariate analysis, PAI-1 (P < .05) and fibrinogen (P < .05) were significantly associated with AGE levels. After performing multivariate analyses, PAI-1 (P < .05) and fibrinogen (P < .05) still remained significant independently. In conclusion, the present study is the first demonstration that PAI-1 and fibrinogen levels were positively associated with serum AGE levels. Advanced glycation end products may be associated with thrombogenesis in humans.
authors.affiliation: The Third Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Enomoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Adachi
authors.forename: Sho-ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Furuki
authors.forename: Asuka
authors.initials: A
authors.lastname: Hino
authors.forename: Akiko
authors.initials: A
authors.lastname: Hiratsuka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takajo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000368:Aged; D015415:Biomarkers; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D013927:Thrombosis / Q000097:blood*
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen