Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment.
Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species as a consequence of localized inflammatory responses in the urethra of males and endocervix of females and also of the activity of commensal lactobacilli in the vaginal flora. This review describes recent advances in the understanding of defense systems against oxidative stress in N. gonorrhoeae and shows that while some of its defenses have similarities to the paradigm established with Escherichia coli, there are also some key differences. These differences include the presence of a defense system against superoxide based on manganese ions and a glutathione-dependent system for defense against nitric oxide which is under the control of a novel MerR-like transcriptional regulator. An understanding of the defenses against oxidative stress in N. gonorrhoeae and their regulation may provide new insights into the ways in which this bacterium survives challenges from polymorphonuclear leukocytes and urogenital epithelial cells.
Seib
Kate L
KL
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia.
Wu
Hsing-Ju
HJ
Kidd
Stephen P
SP
Apicella
Michael A
MA
Jennings
Michael P
MP
McEwan
Alastair G
AG
D002374:Catalase / Q000378:metabolism; D003578:Cytochrome-c Peroxidase / Q000378:metabolism; D004777:Environment; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D018085:Regulon / Q000235:genetics; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D016877:Oxidants; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D008345:Manganese; D006861:Hydrogen Peroxide; D003578:Cytochrome-c Peroxidase; D002374:Catalase; D013482:Superoxide Dismutase