Acute symptomatic seizures and hippocampus damage: DWI and MRS findings.
The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with corresponding lactate detected on MRS in six patients and EEG seizure activity in nine patients. On follow-up, the atrophic hippocampus had an increased ADC in six patients. DWI and MRS may predict development of hippocampal sclerosis.
Parmar
Hemant
H
Department of Neuroradiology, National Neuroscience Institute, Singapore.
Lim
Shih-Hui
SH
Tan
Nigel C K
NC
Lim
C C Tchoyoson
CC
D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000175:diagnosis; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012640:Seizures / Q000150:complications* / Q000175:diagnosis*