A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome.
A (tttta)n microsatellite polymorphism in the promoter of CYP11a gene was investigated in 201 Chinese Han women with polycystic ovary syndrome (PCOS) and 147 control women. The 6/6 genotype was defined with significant difference of CYP11a polymorphism between women with PCOS and control women, and associated with greater BMI in PCOS patients, suggesting a certain role of the six-repeat allele variant in the pathogenesis of Chinese women with PCOS.
Wang
Yong
Y
Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.
Wu
XiaoKe
X
Cao
Yunxia
Y
Yi
Long
L
Chen
Jianxiu
J
D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D002681:China / Q000453:epidemiology; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015994:Incidence; D018895:Microsatellite Repeats / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000201:enzymology* / Q000453:epidemiology* / Q000235:genetics; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D014408:Biomarkers, Tumor; D002786:Cholesterol Side-Chain Cleavage Enzyme