title: Multifocal visual evoked potential latency analysis: predicting progression to multiple sclerosis.
abstract: OBJECTIVE
  To monitor the difference in conversion rates to multiple sclerosis (MS) in 46 patients with optic neuritis between patients with multifocal visual evoked potential latency delay and those with normal latency.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Metropolitan neuro-ophthalmology clinic.
  
  
  METHODS
  Forty-six patients with optic neuritis who did not have a diagnosis of MS on enrollment in the study.
  
  
  METHODS
  Conversion to MS according to the McDonald criteria.
  
  
  RESULTS
  Analysis revealed that only 22 subjects had multifocal visual evoked potential latency delay. Over 1 year, 36.4% of patients with optic neuritis with latency delays progressed clinically to MS compared with 0% of those with normal latencies (P = .03, chi2).
  
  
  CONCLUSIONS
  This may indicate that multifocal visual evoked potential latency delay can assist in predicting progression to future MS.
authors.affiliation: Save Sight Institute, Sydney, NSW, Australia. manuscript@clarefraser.com
authors.forename: Clare
authors.initials: C
authors.lastname: Fraser
authors.forename: Alexander
authors.initials: A
authors.lastname: Klistorner
authors.forename: Stuart
authors.initials: S
authors.lastname: Graham
authors.forename: Raymond
authors.initials: R
authors.lastname: Garrick
authors.forename: Francis
authors.initials: F
authors.lastname: Billson
authors.forename: John
authors.initials: J
authors.lastname: Grigg
mesh_terms: D000704:Analysis of Variance; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009902:Optic Neuritis / Q000150:complications / Q000503:physiopathology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011446:Prospective Studies; D011930:Reaction Time / Q000502:physiology*