title: Terpenoids and bisbibenzyls from Chinese liverworts Conocephalum conicum and Dumortiera hirsuta.
abstract: Four new monoterpene esters, 2alpha,5beta-dihydroxybornane-2-cinnamate (1), 2alpha,5beta-dihydroxybornane-5-acetyl-2-cinnamate (2), 2alpha,5beta-dihydroxybornane-2-p-hydroxycinnamate (3) and 2alpha,5beta-dihydroxy-bornane-2-cis-p-hydroxycinnamate (4), together with a known compound 3,4-dimethoxystyrene (5) were isolated from Chinese liverwort Conocephalum conicum and six known compounds, 5,7-dihydroxycalamenene (6), 7-hydroxycalamenene (7), lunularin (8), riccardin C (9), marchantin C (10) and riccardin D (11) were isolated from Dumortiera hirsuta. Their structures were elucidated by extensive spectral analysis and chemical correlations. Compounds 1 and 8 showed moderate cytotoxicity against human HepG2 cells with IC50 4.5 microg/ml and 7.4 microg/ml, respectively, while compound 8 also showed antimicrobacterial activity against Pseudomonas aeruginosa with minimum inhibitory concentration at 64 microg/ml.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Fan
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification*; D002681:China; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D001632:Bibenzyls; D013729:Terpenes