Musashi1 antigen expression in human fetal germinal matrix development.
Musashi1 is a highly conserved protein found in neural progenitor cells. We examined the expression dynamics of Musashi1 in conjunction with other representative neural progenitor antigenic determinants (Ki-67 and nestin) during 8 different stages of the developing human fetal germinal matrix. Our results indicate that Musashi1 is a useful marker for immature cells in periventricular areas inhabited by stem cells, progenitor cells, and differentiating cells.
Chan
Charles
C
Brown Medical School, Providence, RI 02903, USA.
Moore
Brian E
BE
Cotman
Carl W
CW
Okano
Hideyuki
H
Tavares
Rosemarie
R
Hovanesian
Virginia
V
Pinar
Halit
H
Johanson
Conrad E
CE
Svendsen
Clive N
CN
Stopa
Edward G
EG
D001921:Brain / Q000196:embryology*; D001923:Brain Chemistry; D002552:Cerebral Ventricles / Q000737:chemistry / Q000196:embryology; D047109:Fetal Development; D005865:Gestational Age; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D064231:Nestin; D016601:RNA-Binding Proteins / Q000096:biosynthesis*
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D019394:Ki-67 Antigen; C491297:MSI1 protein, human; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D016601:RNA-Binding Proteins