High-intensity inspiratory muscle training in COPD.
The aim of the present study was to investigate the effects of an interval-based high-intensity inspiratory muscle training (H-IMT) programme on inspiratory muscle function, exercise capacity, dyspnoea and health-related quality of life (QoL) in subjects with chronic obstructive pulmonary disease. A double-blind randomised controlled trial was performed. Sixteen subjects (11 males, mean forced expiratory volume in one second (FEV(1)) 37.4+/-12.5%) underwent H-IMT performed at the highest tolerable inspiratory threshold load (increasing to 101% of baseline maximum inspiratory pressure). Seventeen subjects (11 males, mean FEV(1 )36.5+/-11.5%) underwent sham inspiratory muscle training (S-IMT) at 10% of maximum inspiratory pressure. Training took place three times a week for 8 weeks and was fully supervised. Pre- and post-training measurements of lung function, maximum inspiratory pressure, maximum threshold pressure, exercise capacity, dyspnoea and QoL (Chronic Respiratory Disease Questionnaire; CRDQ) were obtained. H-IMT increased maximum inspiratory pressure by 29%, maximum threshold pressure by 56%, 6-min walk distance by 27 m, and improved dyspnoea and fatigue (CRDQ) by 1.4 and 0.9 points per item, respectively. These changes were significantly greater than any seen following S-IMT. In conclusion, high-intensity inspiratory muscle training improves inspiratory muscle function in subjects with moderate-to-severe chronic obstructive pulmonary disease, yielding meaningful reductions in dyspnoea and fatigue.
Hill
K
K
Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, 6009 Australia. peter.eastwood@health.wa.gov.au
Jenkins
S C
SC
Philippe
D L
DL
Cecins
N
N
Shepherd
K L
KL
Green
D J
DJ
Hillman
D R
DR
Eastwood
P R
PR
D000368:Aged; D004311:Double-Blind Method; D004417:Dyspnea / Q000503:physiopathology / Q000534:rehabilitation; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology / Q000534:rehabilitation; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D007320:Inspiratory Capacity / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000502:physiology; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000534:rehabilitation*; D011788:Quality of Life; D012132:Respiratory Muscles / Q000503:physiopathology*