Surgical excision, cryotherapy, autolimbal transplantation and mitomycin-C in treatment of conjunctival-corneal intraepithelial neoplasia.
OBJECTIVE
To report surgical excision, cryotherapy, autologous conjunctival-limbal transplantation and topical mitomycin C (MMC) in the patient with extensive conjunctival-corneal intraepithelial neoplasia.


METHODS
Case report and literature review.


RESULTS
A 75-year-old woman was referred to our department with the diagnosis of conjunctival-corneal neoplasia. Slit-lamp microscopic examination revealed an extensive papilliform tumoral mass invading the limbus at 360-degrees, and bulbar conjunctiva and cornea. Visual acuity was finger counting from 2 m in the right eye and 20/20 in the left eye. We performed total surgical excision, cryotherapy and autologous conjunctival-limbal transplantation in the right eye. Mitomycin-C 0.02% eye drops four times a day were prescribed for 4 weeks after the surgery. After the treatment, the visual acuity increased to 0.7 in the right eye. Corneal epithelium completely healed within 1 week after the surgery. No corneal epithelium-related problem or neoplasia recurrence were noted during the 2-year follow-up period.


CONCLUSIONS
This technique may be useful in reconstruction of eyes with extensive neoplastic involvement of the conjunctiva, limbus, and cornea. In addition, mitomycin C drops may be useful in preventing postoperative recurrence of conjunctival-corneal intraepithelial neoplasia.
Doganay
Selim
S
Inonu University Medical Faculty, Turgut Ozal Medical Center, Research Hospital, Malatya, Turkey.
Er
Hamdi
H
Tasar
Ahmet
A
Gürses
Iclal
I
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000473:pathology / Q000628:therapy; D003230:Conjunctival Neoplasms / Q000473:pathology / Q000628:therapy*; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D016039:Corneal Transplantation / Q000379:methods*; D017679:Cryotherapy; D019573:Epithelium, Corneal / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016850:Limbus Corneae / Q000601:surgery*; D016685:Mitomycin / Q000627:therapeutic use*; D014182:Transplantation, Autologous
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin