title: Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
abstract: Coordinated control of energy metabolism and glucose homeostasis requires communication between organs and tissues. We identified a neuronal pathway that participates in the cross talk between the liver and adipose tissue. By studying a mouse model, we showed that adenovirus-mediated expression of peroxisome proliferator-activated receptor (PPAR)-g2 in the liver induces acute hepatic steatosis while markedly decreasing peripheral adiposity. These changes were accompanied by increased energy expenditure and improved systemic insulin sensitivity. Hepatic vagotomy and selective afferent blockage of the hepatic vagus revealed that the effects on peripheral tissues involve the afferent vagal nerve. Furthermore, an antidiabetic thiazolidinedione, a PPARg agonist, enhanced this pathway. This neuronal pathway from the liver may function to protect against metabolic perturbation induced by excessive energy storage.
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.forename: Hideki
authors.initials: H
authors.lastname: Katagiri
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
authors.forename: Takehide
authors.initials: T
authors.lastname: Ogihara
authors.forename: Junta
authors.initials: J
authors.lastname: Imai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Junhong
authors.initials: J
authors.lastname: Gao
authors.forename: Keizo
authors.initials: K
authors.lastname: Kaneko
authors.forename: Hiroko
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Ishihara
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Kouichi
authors.initials: K
authors.lastname: Inukai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mizuguchi
authors.forename: Tomoichiro
authors.initials: T
authors.lastname: Asano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Shiota
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Nakazato
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Oka
mesh_terms: D000273:Adipose Tissue / Q000294:innervation / Q000378:metabolism*; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage; D004525:Efferent Pathways / Q000502:physiology; D004734:Energy Metabolism; D005234:Fatty Liver / Q000473:pathology; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007333:Insulin Resistance; D008066:Lipolysis; D008099:Liver / Q000294:innervation* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D010101:Oxygen Consumption; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000502:physiology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D005947:Glucose