title: Positive selection versus demography: evolutionary inferences based on an unusual haplotype structure in Drosophila simulans.
abstract: Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of Drosophila simulans displaying an unusual large-scale haplotype structure. The multilocus analysis, based on summary statistics using specific demographic null models under recombination, indicates that the observed levels of linkage disequilibrium differed significantly from the values expected under different bottleneck and population admixture scenarios. These results indicate that demography alone may not account for the observed pattern of variation and support the previous claim that the data are better described by a model in which an adaptive mutation has not yet gone to fixation.
authors.forename: Humberto
authors.initials: H
authors.lastname: Quesada
authors.forename: Sebastián E
authors.initials: SE
authors.lastname: Ramos-Onsins
authors.forename: Julio
authors.initials: J
authors.lastname: Rozas
authors.forename: Montserrat
authors.initials: M
authors.lastname: Aguadé
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003710:Demography; D004330:Drosophila / Q000235:genetics*; D006239:Haplotypes; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic; D012641:Selection, Genetic