18F-FET PET for planning of thermotherapy using magnetic nanoparticles in recurrent glioblastoma.
OBJECTIVE
Thermotherapy using magnetic nanoparticles (nano cancer therapy) is a new concept of local tumour therapy, which is based on controlled heating of intra-tumoural injected magnetic nanoparticles. The aim of this study was to evaluate the usefulness of PET with a recently introduced amino acid tracer O-(2-[18F]fluoroethyl)-]L-tyrosine (FET) for targeting the nanoparticles implantation.


METHODS
Eleven patients with glioblastoma recurrences underwent MR and FET-PET imaging for planning of the nano cancer therapy. Thereafter, the gross tumour volumes (GTV) were defined, taking into consideration the results of both imaging tools.


RESULTS
The MRI-based mean GTV was 24.3 cm3 (range 2.5-59.7) and the PET-based mean GTV 31.9 cm3 (range 5.2-77.9). On the average the MRI identified an additional 8.9 +/- 4.7 cm3 and the FET-PET scan-an additional 16.5 +/- 15.2 cm3 outside of the common GTV (15.4 +/- 11.0 cm3). The mean final GTV accounted to 33.8 cm3 (range, 5.2-77.9). The additional information of FET-PET led to an increase in GTV by 22-286% in eight patients and to a decrease of 23% and 26%, respectively, in two patients. In one patient, the final GTV was defined on the basis of MRI data only.


CONCLUSIONS
FET-PET adds important information on the actual tumour volume in recurrent glioblastomas and is highly valuable for defining the target volume for the nano cancer therapy.
Plotkin
Michail
M
Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Germany. michail.plotkin@charite.de
Gneveckow
Uwe
U
Meier-Hauff
Klaus
K
Amthauer
Holger
H
Feussner
Annelie
A
Denecke
Timm
T
Gutberlet
Matthias
M
Jordan
Andreas
A
Felix
Roland
R
Wust
Peter
P
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D049329:Nanostructures; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D014443:Tyrosine / Q000031:analogs & derivatives*
C117289:O-(2-fluoroethyl)tyrosine; D014443:Tyrosine