title: Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
abstract: OBJECTIVE
  To summarize the effects of novel hormones (leptin, ghrelin, adiponectin, resistin, and PYY3-36) secreted from adipose tissue and the gastrointestinal tract that have been discovered to exert different effects on several reproductive functions, such as the hypothalamic-pituitary-gonadal axis, embryo development, implantation physiology, and clinically relevant conditions.
  
  
  METHODS
  A MEDLINE computer search was performed to identify relevant articles.
  
  
  RESULTS
  Leptin and ghrelin exert important roles on body weight regulation, eating behavior, and reproduction, acting on the central nervous system and target reproductive organs. As a marker of adequate nutritional stores, these hormones may act on the central nervous system to initiate the complex process of puberty and maintain normal reproductive function. In addition, leptin and ghrelin and their receptors are involved in reproductive events such as gonadal function, embryo development, and embryo-endometrial interaction.
  
  
  CONCLUSIONS
  Leptin and ghrelin and other adipose tissue-secreted hormones have significant effects on reproduction. Acting through the brain, these hormones may serve as links between adipose tissue and the reproductive system to supply and regulate energy needs for normal reproduction and pregnancy. Future studies are needed to further clarify the role of these hormones in reproductive events and other related gynecological conditions.
authors.affiliation: Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain.
authors.forename: Erdal
authors.initials: E
authors.lastname: Budak
authors.forename: Manuel
authors.initials: M
authors.lastname: Fernández Sánchez
authors.forename: José
authors.initials: J
authors.lastname: Bellver
authors.forename: Ana
authors.initials: A
authors.lastname: Cerveró
authors.forename: Carlos
authors.initials: C
authors.lastname: Simón
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019317:Evidence-Based Medicine; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005836:Genitalia, Female / Q000378:metabolism*; D005837:Genitalia, Male / Q000378:metabolism*; D054439:Ghrelin; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000378:metabolism; D016239:MEDLINE; D008297:Male; D010446:Peptide Fragments; D036361:Peptide Hormones / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism; D025941:Protein Interaction Mapping; D012098:Reproduction / Q000502:physiology*; D052243:Resistin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D012739:Gonadal Steroid Hormones; D020738:Leptin; D010446:Peptide Fragments; D036361:Peptide Hormones; D052243:Resistin; D019894:Peptide YY; C061785:peptide YY (3-36)