Clinical features and prognosis of patients with idiopathic inflammatory myopathies and anti-Jo-1 antibodies.
The idiopathic inflammatory myopathies are a heterogeneous group of diseases that can involve various systems. Antibodies directed against aminoacyl-tRNA synthetases, such as anti-Jo-1 antibodies, are strongly associated with a syndrome which consists of myositis, interstitial lung disease (ILD), arthritis and Raynaud's phenomenon. Forty-one patients with various forms of idiopathic inflammatory myopathies were assessed: 14 patients with anti-Jo-1 antibodies and 27 patients without anti-Jo-1 antibodies as a control group. We retrospectively analysed clinical symptoms, treatment and outcome in both groups. Patients with anti-Jo-1 antibodies more often had ILD (64.2 vs. 11.1%), arthritis (64.2 vs. 18.1%) and Raynaud's phenomenon (38 vs. 0%). Patients without the anti-Jo-1 antibody presented worse muscle strength and more frequently myalgia (37 vs. 21%), cutaneous rash (18.5 vs. 7%), heliotrope rash (29% vs. 7%) and periungueal changes (22 vs. 0%) than the anti-Jo-1-positive patients. Outcome was good in both groups. Improvement was achieved in the 14 (100%) Jo-1 positive patients, and in 25 (92.5%) controls. Two (7.5%) patients from control group achieved remission.
Mielnik
Pawel
P
Institute of Rheumatology, Department of Connective Tissue Diseases, Warsaw, Poland. mielnik_p@ir.ids.pl
Wiesik-Szewczyk
Ewa
E
Olesinska
Marzena
M
Chwalinska-Sadowska
Hanna
H
Zabek
Jakub
J
D000974:Antibodies, Antinuclear / Q000097:blood*; D001168:Arthritis / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D009220:Myositis / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D011379:Prognosis; D011928:Raynaud Disease / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies
D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody