title: Nitric oxide levels in disruptive behavioral disorder.
abstract: There are various evidences of the role of nitric oxide (NO) in several neuropsychiatric disorders. However, there is no clinical study which investigated the role of NO in disruptive behavioral disorders (DBD). The aim of this study is to investigate the relation between NO levels and DBD. NO levels were measured in serum from 45 patients diagnosed as having DBD (30 patients with a diagnosis of attention deficit and hyperactivity disorder [ADHD] and 15 with ADHD + oppositional defiant disorder [ODD]) and 51 healthy control subjects. It is statistically significant that the pure ADHD group's blood NO levels are lower than those of both the ADHD + ODD and control groups. There was no significant difference between the ADHD + ODD group and the controls. The difference of the NO levels in DBD may indicate the effect of NO in the etiology of this disorder spectrum.
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, University of Dokuz Eylul, Izmir, Turkey. fvaroltas@hotmail.com
authors.forename: Fatma
authors.initials: F
authors.lastname: Varol Tas
authors.forename: Taner
authors.initials: T
authors.lastname: Guvenir
authors.forename: Gultekin
authors.initials: G
authors.lastname: Tas
authors.forename: Burcu
authors.initials: B
authors.lastname: Cakaloz
authors.forename: Murat
authors.initials: M
authors.lastname: Ormen
mesh_terms: D019958:Attention Deficit and Disruptive Behavior Disorders / Q000201:enzymology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D009569:Nitric Oxide