Synthesis and antitumor activity of two natural N-acetylglucosamine-bearing triterpenoid saponins: lotoidoside D and E.
Two natural triterpenoid saponins bearing N-acetylglucosamine, lotoidoside D and lotoidoside E, which had been available only from Glinus lotoides growing in Egyptian desert, were facilely synthesized from readily available oleanolic acid. Preliminary pharmacological research showed their antitumor activity against HeLa cell.
Yan
Mao-Cai
MC
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, PR China.
Liu
Yang
Y
Chen
Hong
H
Ke
Ying
Y
Xu
Qing-Chun
QC
Cheng
Mao-Sheng
MS
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008956:Models, Chemical; D035704:Molluginaceae; D010936:Plant Extracts / Q000378:metabolism; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D010936:Plant Extracts; D012503:Saponins; C513947:lotoidoside D; C513948:lotoidoside E