Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii.
Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.
Liu
Qian
Q
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Harrington
David
D
Kohen
James L
JL
Vemulpad
Subramanyam
S
Jamie
Joanne F
JF
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D041621:Eremophila Plant / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
C514660:3,8-dihydroxyserrulatic acid; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; C514661:serrulatic acid