title: Kidney transplantation without prior dialysis in children: the Eurotransplant experience.
abstract: Kidney transplantation without prior dialysis may prevent dialysis-associated morbidity. We analyzed the outcome of 1113 first kidney transplants in children performed between 1990 and 2000 in the Eurotransplant community. Enlistment for a deceased donor kidney before start of dialysis (127/895, 14%) made dialysis redundant in 55% of cases. Mean residual creatinine clearance at transplantation of these patients was 8 mL/min/1.73 m(2). Pre-emptive transplantations of deceased donor kidneys showed less acute rejections (52% vs. 37% rejection-free at 3 years, p = 0.039), compared to transplantations following dialysis. The difference in graft survival between non-dialyzed and dialyzed patients (82% vs. 69% at 6 year) did not reach statistical significance (p = 0.055). No differences were noted after living donor transplantation. Multivariate analysis showed that the period of transplantation was the strongest predictor of graft survival (p < 0.001). Congenital structural abnormalities such as primary kidney disease predominated in nondialyzed patients as compared to dialyzed patients (p < 0.001); this factor did not influence graft survival. Based on our conclusion that pre-emptive transplantation is at least as good as post-dialysis transplantation, as well as on quality of life arguments, we recommend to consider pre-emptive transplantation in children with end-stage renal failure.
authors.affiliation: Department of Pediatric Nephrology, Erasmus MC - Sophia, Rotterdam, The Netherlands. k.cransberg@erasmusmc.nl
authors.forename: K
authors.initials: K
authors.lastname: Cransberg
authors.forename: J M A
authors.initials: JM
authors.lastname: Smits
authors.forename: G
authors.initials: G
authors.lastname: Offner
authors.forename: J
authors.initials: J
authors.lastname: Nauta
authors.forename: G G
authors.initials: GG
authors.lastname: Persijn
mesh_terms: D000293:Adolescent; D002648:Child; D005060:Europe / Q000453:epidemiology; D005500:Follow-Up Studies; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D006973:Hypertension; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D006435:Renal Dialysis; D015996:Survival Rate; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents