Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling.
Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key pathologic component of various vascular diseases, including abdominal aortic aneurysms, brain arteriovenous malformations and atherosclerosis. Based on findings from observational studies that analysed human intracranial aneurysms and experimental studies that utilized animal models, an emerging concept suggests that a key component of the pathophysiology of intracranial aneurysms is sustained abnormal vascular remodeling coupled with inflammation. This concept may provide a new treatment strategy to utilize agents to inhibit inflammation or cytokines produced by inflammatory cells such as matrix metalloproteinases. Such an approach would aim to stabilize these vascular lesions and prevent future expansion or rupture.
Hashimoto
Tomoki
T
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Avenue, Room 3C-38, 94110, USA. hashimoto@anesthesia.ucsf.edu
Meng
Hui
H
Young
William L
WL
D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000503:physiopathology; D002532:Intracranial Aneurysm / Q000473:pathology / Q000503:physiopathology*