Comparative analyses of a family of potential self-replicators: the subtle interplay between molecular structure and the efficacy of self-replication.
It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and replication efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes.
Pearson
Russell J
RJ
Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
Kassianidis
Eleftherios
E
Slawin
Alexandra M Z
AM
Philp
Douglas
D
D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
D005663:Furans; D011725:Pyridines