title: [Evaluation of transposed ovarian function in young women with cervical cancer].
abstract: OBJECTIVE
  To evaluate the function of transposed ovary and its affecting factors in young women with cervical cancer.
  
  
  METHODS
  The patients of cervical cancer who were admitted into Peking University People's Hospital during September 1999 to January 2004 and underwent ovarian transposition in peritoneal cavity, were followed regularly and analyzed retrospectively. The questionnaire of climacteric symptoms and sexual activity were designed and delivered to all patients. Serum levels of estradiol and follicle-stimulating hormone (FSH) were measured and transposed ovaries were observed with B ultrasound post operation.
  
  
  RESULTS
  The climacteric symptoms of patients who received transposed ovary unilaterally or bilaterally were not difference significantly at the mean follow-up times of 14.2 and 17.4 months, respectively (P > 0.05). However, of the patients who underwent adjuvant radiotherapy and/or chemotherapy post-surgery, climacteric symptoms were significantly more common (85%) than without adjuvant therapy (13%) (P < 0.05). Serum estradiol, and FSH levels and climacteric symptoms of the patients, who received adjuvant radiotherapy, had no significant difference between the ovaries transposed 2 cm above and 2 cm below anterosuperior horizontal iliac spine.
  
  
  CONCLUSIONS
  Transposed ovary to peritoneal cavity could preserve the function of ovary. Once the patients undergo adjuvant radiotherapy, the function of transposed ovary will be affected wherever the transposed ovary locates 2 cm above or below anterosuperior horizontal iliac spine.
authors.affiliation: Department of Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jian-liu
authors.initials: JL
authors.lastname: Wang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Liang
authors.forename: Shi-jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Hui-mei
authors.initials: HM
authors.lastname: Xing
authors.forename: Li-hui
authors.initials: LH
authors.lastname: Wei
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D004358:Drug Therapy / Q000379:methods; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D019584:Hot Flashes / Q000209:etiology; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods; D008197:Lymph Node Excision; D008875:Middle Aged; D010053:Ovary / Q000503:physiopathology* / Q000601:surgery; D011182:Postoperative Care / Q000379:methods*; D016649:Primary Ovarian Insufficiency / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone