[Pain and genetics].
Genetic factors can explain a significant amount of the variance in the perception of pain, sensitivity to painful stimuli and development of chronic pain. Twin studies, association studies and linkage analysis have located DNA sequences and SNPs that may be involved in the regulation of pain. Individual genes have an influence on the reaction to experimental painful stimuli, and certain genes are probably involved in painful clinical conditions. Optimal pain control and counselling of patients may be achievable through research into the genetic mechanisms involved in pain.
Møller
Anette Torvin
AT
Arhus Universitetshospital, Arhus Sygehus, Neurologisk Afdeling, Dansk Smerteforskningscenter. anette@torvin.dk
Kølvraa
Steen
S
Jensen
Troels Staehelin
TS
D002394:Catechol O-Methyltransferase / Q000235:genetics; D002908:Chronic Disease; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011957:Receptors, Opioid / Q000235:genetics*
D011957:Receptors, Opioid; D002394:Catechol O-Methyltransferase