title: In vitro activity of cefditoren: antimicrobial efficacy against major respiratory pathogens from Asian countries.
abstract: In this study we evaluated the in vitro activities of cefditoren and 14 other comparator agents against 1025 isolates of major respiratory tract pathogens including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae and Staphylococcus aureus. Bacterial isolates were collected from 11 Asian countries. The majority of S. pneumoniae isolates (98.8%) were susceptible to cefditoren. The MIC(50) and MIC(90) values (minimum inhibitory concentrations for 50% and 90% of the organisms, respectively) of S. pneumoniae were <or=0.06 microg/mL and 1 microg/mL, respectively. These values were 2-32-fold lower than those of the other cephalosporins. Activity against S. pneumoniae was observed irrespective of penicillin or macrolide resistance. Cefditoren was also active against methicillin-susceptible S. aureus (100% susceptible; MIC(90)=1 microg/mL), H. influenzae (100% susceptible; MIC(90)<or=0.016 microg/mL) and M. catarrhalis (MIC(90)=0.016 microg/mL). However, the cefditoren MIC(90) of K. pneumoniae reached only 64 microg/mL (81.4% susceptible), which may be due to the high incidence of extended-spectrum beta-lactamases in Asian countries. Therefore, cefditoren should be considered as a therapeutic option for the treatment of respiratory tract infections in Asian countries.
authors.affiliation: Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Won Sup
authors.initials: WS
authors.lastname: Oh
authors.forename: Sulhee
authors.initials: S
authors.lastname: Park
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jin Yang
authors.initials: JY
authors.lastname: Baek
authors.forename: Ji-Yoeun
authors.initials: JY
authors.lastname: Suh
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Lee
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D002511:Cephalosporins / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects; D012137:Respiratory System / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C073460:cefditoren