Electrochemical oxidation of isoniazid catalyzed by (FcM)TMA at the platinum electrode and its practical analytical application.
The electrocatalytic oxidation of isoniazid (INH) by (ferrocenylmethyl)trimethylammonium [(FcM)TMA] at the platinum electrode in 0.10 M Na2SO4 aqueous solution was studied by cyclic voltammetry (CV). Although INH itself showed a very poor electrochemical response at the platinum electrode, the response could be greatly enhanced by using (FcM)TMA as a mediator, which enables a sensitive electrochemical determination of the substrate INH. The reaction rate constant for catalytic oxidation reaction was evaluated as (3.98+/-0.10)x10(3) M(-1) s(-1) by using chronoamperometry (CA). Experimental conditions such as supporting electrolyte and its concentration, solution pH, and the concentrations of the catalyst (FcM)TMA and the substrate INH were investigated to maximize the current efficiency of the electrocatalytic oxidation. The method can be used for the sensitive practical determination of INH, and also opens an avenue for using (FcM)TMA as a mediator in electroanalytical determination which is very simple, cheap, and rapid. Furthermore, no sample pretreatment or time-consuming extraction steps are required prior to the analysis.
Gao
Zuo-Ning
ZN
Key Laboratory of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, People's Republic of China. gaozn@nxu.edu.cn
Han
Xiao-Xia
XX
Yao
Hui-Qin
HQ
Liang
Bin
B
Liu
Wan-Yi
WY
D002384:Catalysis; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007538:Isoniazid / Q000737:chemistry*; D010084:Oxidation-Reduction; D010984:Platinum
D005296:Ferrous Compounds; D010984:Platinum; D007538:Isoniazid