[NASH model-- role of interleukin-1 receptor].
Although the anti-inflammatory effect of interleukin-1 (IL-1) receptor antagonist (IL-1Ra) has been described, the contribution of this cytokine to non-alcoholic steatohepatitis (NASH) remains unclear. Our aim was to ascertain whether deficiency of IL-1Ra leads to hepatic inflammation and fibrosis upon consumption of an atherogenic diet. IL-1Ra deficient mice (IL-1Ra(-/-)) showed severe steatosis and pericellular fibrosis containing many inflammatory cells following 20 weeks of an atherogenic diet when compared with wild type (WT) mice. The hepatic histology of IL-1Ra(-/-) mice is similar to that of NASH.
Sawada
Shojiro
S
Department of Internal Medicine, National Defense Medical College.
Saito
Hidetsugu
H
Kusuhara
Masatoshi
M
D000818:Animals; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000209:etiology*; D015870:Gene Expression; D053590:Interleukin 1 Receptor Antagonist Protein; D050356:Lipid Metabolism / Q000235:genetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D017472:Receptors, Interleukin-1 / Q000502:physiology*; D012795:Sialoglycoproteins / Q000172:deficiency* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins