LPO and apoptosis during pulmonary tuberculosis.
LPO and apoptosis in blood mononuclear cells were studied in patients with pulmonary tuberculosis before and during treatment with standard chemotherapeutics. Pulmonary tuberculosis was accompanied by LPO activation and intensification of apoptosis in lymphocytes and monocytes. These changes were observed before and after the course of intensive care. The intensity of lipid peroxidation retuned to normal, while activity of apoptosis remained high after therapy.
Novitskii
V V
VV
Department of Pathophysiology, Central Research Laboratory, Siberian State Medical University, Russian Federal Agency for Public Health and Social Development, Tomsk.
Strelis
A K
AK
Tkachenko
S B
SB
Esimova
I E
IE
Shil'ko
T A
TA
Urazova
O I
OI
Voronkova
O V
OV
Sinitsina
V A
VA
Filinyuk
O V
OV
Zemlyanaya
N A
NA
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D017209:Apoptosis; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy*
D000995:Antitubercular Agents