title: Maltoma of the thyroid and Sjögren's syndrome in a woman with Hashimoto's thyroiditis.
abstract: We report the case of a 70-yr-old woman with maltoma of the thyroid, Sjögren's syndrome, and a history of Hashimoto's thyroiditis. The patient underwent a total thyroidectomy for a recently growing mass of the thyroid, while being treated with L-thyroxine for Hashimoto's thyroiditis. Postoperatively, routine histologic examination was consistent with the diagnosis of chronic lymphocytic thyroiditis of autoimmune etiology. Three years later, the patient presented with high temperature, anorexia, and coughing. This time, a microscopic examination of deeper thyroid tissue sections and an immunohistochemical study revealed a low-grade, non-Hodgkin lymphoma, MALT type. Simultaneously, the diagnosis of Sjögren's syndrome was established and the patient is currently under investigation for generalized lymphoma. This case clearly demonstrates the difficulty in differentially diagnosing Hashimoto's thyroiditis from low-grade MALT lymphoma by the use of routine histologic examination.
authors.affiliation: Department of Pathology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Athina
authors.initials: A
authors.lastname: Androulaki
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Syriou
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Lazaris
authors.forename: Thomas
authors.initials: T
authors.lastname: Paterakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Pikazis
authors.forename: Thomas
authors.initials: T
authors.lastname: Papathomas
authors.forename: Margarita
authors.initials: M
authors.lastname: Anapliotou
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D050031:Hashimoto Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D014408:Biomarkers, Tumor; D013974:Thyroxine