Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest.
OBJECTIVE
To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG).


METHODS
Prospective observational study.


METHODS
Population-based cohort in Germany.


METHODS
Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG).


METHODS
None.


METHODS
Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy.


RESULTS
After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups.


CONCLUSIONS
The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.
Wiegratz
Inka
I
Department of Obstetrics and Gynecology, J. W. Goethe University, Frankfurt am Main, Germany.
Mittmann
Katrin
K
Dietrich
Horst
H
Zimmermann
Thomas
T
Kuhl
Herbert
H
D000328:Adult; D017677:Age Distribution; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens / Q000008:administration & dosage; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D018873:Pregnancy Rate; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D028761:Withholding Treatment / Q000706:statistics & numerical data*
D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D004997:Ethinyl Estradiol; C023635:dienogest; D009277:Nandrolone