title: Single-shot antithrombin in human pancreas-kidney transplantation: reduction of reperfusion pancreatitis and prevention of graft thrombosis.
abstract: Reperfusion pancreatitis and graft thrombosis often induce early graft loss in simultaneous pancreas-kidney (SPK) transplantation. Antithrombin (AT) is a coagulatory inhibitor with pleiotropic activities that reduces experimental ischemia/reperfusion injury. This study retrospectively analyses prophylactic high-dose AT application in patients with first SPK. In an university transplantation center, 53 consecutive patients with SPK were studied without randomization. In one group, 3000 IU of AT was given intravenously before pancreatic reperfusion (AT, n = 24). Patients receiving standard therapy including postoperative AT supplementation (controls, n = 29) served as controls. Daily blood sampling was performed as a part of the clinical routine during four postoperative days. There were no differences in demographic and laboratory parameters [donor/recipient age, ischemia time, perfusion solution, body weight, mismatches] between both groups. Baseline creatinine values were lower in the control group versus AT group (P < 0.05). Coagulatory parameters and bleeding incidence were not influenced by AT, while incidence of graft thrombosis was reduced (control: 7/29; AT: 4/24; relative reduction of risk: -33%; P < 0.05). Single-shot AT application during SPK modulated serum lipase activity on postoperative days 2 and 3, and minimized risk for graft thromboses without increasing perioperative bleeding. This new concept should deserve testing in a prospective clinical trial.
authors.affiliation: Department of Surgery, Ludwig Maximilians University of Munich Grosshadern, Munich, Germany.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Fertmann
authors.forename: Cosmas D
authors.initials: CD
authors.lastname: Wimmer
authors.forename: Helmut P
authors.initials: HP
authors.lastname: Arbogast
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Illner
authors.forename: Anwar
authors.initials: A
authors.lastname: Tarabichi
authors.forename: Ivan
authors.initials: I
authors.lastname: Calasan
authors.forename: Christian
authors.initials: C
authors.lastname: Dieterle
authors.forename: Walter
authors.initials: W
authors.lastname: Land
authors.forename: Karl-Walther
authors.initials: KW
authors.lastname: Jauch
authors.forename: Johannes N
authors.initials: JN
authors.lastname: Hoffmann
authors.forename: N Hoffmann
authors.initials: NH
authors.lastname: Johannes
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation / Q000379:methods*; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000379:methods*; D010195:Pancreatitis / Q000517:prevention & control*; D044062:Prostaglandins I / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D012306:Risk; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D000991:Antithrombins; D007166:Immunosuppressive Agents; D044062:Prostaglandins I; D008049:Lipase