title: Mesenchymal stem cellular adhesion and cytotoxicity study of random biopolyester scaffolds for tissue engineering.
abstract: Mesenchymal stem cells (MSCs) were isolated from the bone marrow of rabbits and inoculated respectively on 3D scaffolds of poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) (PHBV), poly(butylenes succinate) (PBS) and different blends (100/0, 80/20, 50/50, 20/80, 0/100) (Wt%) in vitro. It was found that the (50/50) blends possessed the best performance on adhesion and cytotoxicity of MSCs. The scanning electronic microscopy (SEM) results showed that the (50/50) blends had the appropriate roughness for MSCs to attach and grow, which may be used as a suitable biomaterial to create small caliber vascular grafts.
authors.affiliation: Department of Cardiac Surgery, Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, 100037, Beijing, Peoples Republic of China. hkcytangxiujie@sina.com
authors.forename: X J
authors.initials: XJ
authors.lastname: Tang
authors.forename: Q Y
authors.initials: QY
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002478:Cells, Cultured; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology*; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011817:Rabbits; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D007770:L-Lactate Dehydrogenase