title: Feasibility of azithromycin prophylaxis during a pertussis outbreak among healthcare workers in a university hospital in Paris.
abstract: The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.
authors.affiliation: Service de Sante Publique, Groupe Hospitalier Cochin-St. Vincent de Paul, Paris, France.
authors.forename: Camila
authors.initials: C
authors.lastname: Giugliani
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Vidal-Trecan
authors.forename: Souleymane
authors.initials: S
authors.lastname: Traore
authors.forename: Herve
authors.initials: H
authors.lastname: Blanchard
authors.forename: Gabriela
authors.initials: G
authors.lastname: Spiridon
authors.forename: Florence
authors.initials: F
authors.lastname: Rollot
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.forename: Myriam
authors.initials: M
authors.lastname: Gorodestski
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Marande
authors.forename: Christophe
authors.initials: C
authors.lastname: Vinsonneau
authors.forename: Loic
authors.initials: L
authors.lastname: Guillevin
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon-Ceron
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D017963:Azithromycin / Q000008:administration & dosage*; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious; D005240:Feasibility Studies; D005260:Female; D005602:France; D006282:Health Personnel; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011446:Prospective Studies; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin