Role of laser energy density for photodynamic therapy of radiation injuries of the skin.
The role of different laser energy densities used in photodynamic therapy in the reparation of radiation ulcers caused by X-ray exposure in a dose of 80 Gy was studied. Tissue reparation manifested differently at different laser energy densities. After photodynamic therapy at energy density of 0.1 J/cm2 the rate of healing was notably higher during early periods. After exposure at 5 and 40 J/cm2 acceleration of ulcer healing was observed 14 and more days after the treatment, indicating the emergence of another mechanism of photodynamic therapy effect. Laser energy density of 5 J/cm2 was the most effective for maximally complete healing of radiation ulcers.
Nikitina
R G
RG
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.
Kaplan
M A
MA
Morozova
T G
TG
Drozhzhina
V V
VV
Epatova
T V
TV
Luk'yanova
E Yu
EY
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D053685:Laser Therapy / Q000379:methods; D007834:Lasers; D010778:Photochemotherapy / Q000379:methods*; D011832:Radiation Injuries / Q000628:therapy*; D051381:Rats; D012867:Skin / Q000528:radiation effects*; D013997:Time Factors; D014945:Wound Healing; D014965:X-Rays