title: Effect of resistance training on risk of coronary artery disease in women with multiple sclerosis.
abstract: The effects of a lower-extremity progressive resistance-training program (PRT) on risk factors for coronary artery disease (CAD) were determined in patients with multiple sclerosis (MS). Twelve ambulatory women with MS (47.3+/-4.7 years; Expanded Disability Status Score (EDSS), 4.00+/-1.37) completed twice weekly lower-body PRT for 8 weeks. Knee extensor and ankle flexor strength improved significantly (p<0.05) after training, and self-reported fatigue decreased (p<0.05). Serum triglyceride concentrations decreased (p<0.05) but body-weight and fatness, blood pressure, and serum glucose, total cholesterol and high-density lipoprotein cholesterol were unchanged. However, the number of CAD risk factors that reached the clinical threshold for each subject declined after PRT, suggesting that resistance training can promote CAD risk reduction in ambulatory female MS subjects.
authors.affiliation: Department of Applied Physiology and Kinesiology, Applied Human Physiology Laboratory, University of Florida, Gainesville, Florida 32611, USA. lwhite@hhp.ufl.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: White
authors.forename: S C
authors.initials: SC
authors.lastname: McCoy
authors.forename: V
authors.initials: V
authors.lastname: Castellano
authors.forename: M A
authors.initials: MA
authors.lastname: Ferguson
authors.forename: W
authors.initials: W
authors.lastname: Hou
authors.forename: R H
authors.initials: RH
authors.lastname: Dressendorfer
mesh_terms: D000203:Activities of Daily Living; D003324:Coronary Artery Disease / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D012307:Risk Factors; D018709:Statistics, Nonparametric