Effect of ascovertin on morphological changes in rat retina exposed to high-intensity light.
Experiments on rats showed that high-intensity light exposure (6000 lux, 6 h) caused focal injuries in the retina. The most sensitive structures were neurosensory cells, pigmented epithelium, radial gliocytes, and choroid capillaries. Injection of ascovertin led to disappearance of foci of injuries, limited blood supply disorders in the retina, and destruction of neurosensory and glial cells.
Logvinov
S V
SV
Department of Histology, Embryology, and Cytology, Siberian State Medical University, Toms.
Plotnikov
M B
MB
Varakuta
E Yu
EY
Zhdankina
A A
AA
Potapov
A V
AV
Mikhulya
E P
EP
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D044948:Flavonols / Q000008:administration & dosage; D005609:Free Radicals; D008027:Light; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011833:Radiation Injuries, Experimental; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors
D044948:Flavonols; D005609:Free Radicals; C513231:ascovertin; D011794:Quercetin; C003377:taxifolin; D001205:Ascorbic Acid