Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management.
A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode = 7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.
Simoni
Jane M
JM
Department of Psychology, University of Washington, Seattle, Washington, 98195-1525, Box 351525, USA. jsimoni@u.washington.edu
Kurth
Ann E
AE
Pearson
Cynthia R
CR
Pantalone
David W
DW
Merrill
Joseph O
JO
Frick
Pamela A
PA
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D019468:Disease Management; D017408:Guidelines as Topic; D006801:Humans; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012650:Self Disclosure
D044966:Anti-Retroviral Agents