title: Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
abstract: Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Oxford Road, Manchester M13 9PT, UK. lorna.kennedy@mahchester.ac.uk
authors.forename: L J
authors.initials: LJ
authors.lastname: Kennedy
authors.forename: S
authors.initials: S
authors.lastname: Quarmby
authors.forename: G M
authors.initials: GM
authors.lastname: Happ
authors.forename: A
authors.initials: A
authors.lastname: Barnes
authors.forename: I K
authors.initials: IK
authors.lastname: Ramsey
authors.forename: R M
authors.initials: RM
authors.lastname: Dixon
authors.forename: B
authors.initials: B
authors.lastname: Catchpole
authors.forename: C
authors.initials: C
authors.lastname: Rusbridge
authors.forename: P A
authors.initials: PA
authors.lastname: Graham
authors.forename: N S
authors.initials: NS
authors.lastname: Hillbertz
authors.forename: C
authors.initials: C
authors.lastname: Roethel
authors.forename: W J
authors.initials: WJ
authors.lastname: Dodds
authors.forename: N G
authors.initials: NG
authors.lastname: Carmichael
authors.forename: W E R
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000483:Alleles; D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000276:immunology*; D004285:Dogs; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D007037:Hypothyroidism / Q000235:genetics / Q000276:immunology / Q000662:veterinary*
chemical_list: D000949:Histocompatibility Antigens Class II