Selected haematological and biochemical parameters of blood in rats after subchronic administration of vanadium and/or magnesium in drinking water.
The purpose of these studies was to evaluate the effect of selected vanadium and magnesium doses on certain haematological and biochemical blood parameters in rats. Outbred 2-month-old, albino male Wistar rats received for a period of 6 weeks, as a sole drinking liquid, the following water solutions: group II, sodium metavanadate (SMV) at a concentration of 0.125 mg V/mL; group III, magnesium sulphate (MS) at a concentration of 0.06 mg Mg/mL; and group IV, SMV-MS solution at the same concentrations. The control group received at this time deionized water to drink. It was calculated that group II ingested with drinking water about 10.7 mg V/kg b. w./24 h, group III 6 mg Mg/kg b. w./24 h, and group IV about 9 mg V and 4.5 mg Mg/kg b. w./24 h. The exposure to vanadium alone (group II) led to a statistically significant decrease in body weight gain, food and fluid intakes. Moreover, in the same group of rats a statistically significant decrease in the RBC count, Hb concentration, MCV, and MCH values was demonstrated. Additionally, a statistically significant decrease in the plasma L-ascorbic acid concentration and a significant increase in MDA concentration in blood in this group were found. Instead, after the administration of magnesium alone (group III), a statistically significant decrease in the fluid intake and in the L-ascorbic acid concentration in plasma was noted. Furthermore, in the same group of rats a statistically significant increase in Hb level and in the plasma magnesium concentration was demonstrated. Two-way analysis of variance (ANOVA) did not reveal the interactions between V and Mg.
Scibior
Agnieszka
A
Department of Cell Biology, Institute of Environmental Protection, John Paul II Catholic University of Lublin, Kraśnicka Ave 102, 20-718, Lublin, Poland. cellbiol@kul.lublin.pl
Zaporowska
Halina
H
Ostrowski
Jarosław
J
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D004347:Drug Interactions; D004906:Erythrocyte Count; D004909:Erythrocyte Indices / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D008274:Magnesium / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014639:Vanadium / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D014881:Water Supply; D015430:Weight Gain / Q000187:drug effects
D006454:Hemoglobins; D014639:Vanadium; D008315:Malondialdehyde; D008274:Magnesium; D001205:Ascorbic Acid