title: [Polylactic acid injections (Newfill) in the treatment of facial lipodystrophy in HIV-positive patients].
abstract: BACKGROUND
  Lipodystrophy is a side-effect associated with treatment for human immunodeficiency virus (HIV) and is found chiefly on the face (disappearance of buccal fat pads) and is detrimental to self-esteem.
  
  
  METHODS
  This was a retrospective study in HIV-positive patients with facial lipoatrophy treated between 1999 and 2004 by means of subcutaneous injections of polylactic acid (Newfill). We assessed the efficacy of treatment, the number of injections given, treatment methods and adverse effects.
  
  
  RESULTS
  Eighty-three patients were treated between 1999 and 2004. Each patient received a mean of between 3 and 4 treatment sessions comprising subdermal injection of 1 ampoule of Newfill into each cheek. Ultrasound assessment of the dermis over the cheekbone was performed in 45 patients and showed an increase in dermal thickness of between 3 and 7 mm. Following injection, edema was observed in all cases and lasted between 1 and 2 days. Five patients presented bruising at the injection sites. Two patients presented asymmetry lasting 4 months and requiring correction. Four patients had non-inflammatory granulomas, which were not visible but were palpable in 2 cases; all nodules regressed after 4 months.
  
  
  CONCLUSIONS
  Treatment of facial lipoatrophy in HIV patients by injection of polylactic acid (Newfill) was shown to be efficacious in the majority of subjects. Training in the administration of this treatment is needed to ensure optimal efficacy and safety. A number of technical difficulties led to changes in treatment methods, i.e. routine adoption of a mask and protective glasses and use of a Luer-lock syringe due to blockage of syringes in more than 20% of cases, with splashing; increase in dilution volume from 3 to 5 ml; use of a centrifuge to ensure greater homogeneity of the solution; use of lidocaine in place of water for injections in order to reduce pain for patients.
authors.affiliation: Service de Dermatologie, Centre Hospitalier de Cannes, 15 avenue des Broussailles, 06400 Cannes. isaacbodokh@yahoo.fr
authors.forename: I
authors.initials: I
authors.lastname: Bodokh
authors.forename: P
authors.initials: P
authors.lastname: Simonet
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D020405:Dermis / Q000000981:diagnostic imaging; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D019736:Prostheses and Implants; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)