Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
Niks
E H
EH
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. ehniks@lumc.nl
Kuks
J B M
JB
Roep
B O
BO
Haasnoot
G W
GW
Verduijn
W
W
Ballieux
B E P B
BE
De Baets
M H
MH
Vincent
A
A
Verschuuren
J J G M
JJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009157:Myasthenia Gravis / Q000235:genetics* / Q000276:immunology*; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C052238:HLA-DR14; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases