title: [Prevalence of vaginal candidiasis in pregnant women. Identification of yeasts and susceptibility to antifungal agents].
abstract: Pregnant women are more susceptible to both vaginal colonization and infection by yeast. Our objectives were to determine the prevalence in pregnant women of yeasts isolated from vaginal exudates and their susceptibility to current antifungal drugs. A total of 493 patients was studied between December 1998 and February 2000. The prevalence of Candida spp. was 28% (Candida albicans 90.4%; Candida glabrata 6.3%; Candida parapsilosis 1.1%, Candida kefyr 1.1 %; unidentified species 1.1 %). The diffusion test in Shadomy agar was employed to determine the susceptibility to fluconazole, ketoconazole, itraconazole and nistatine. All C. albicans, C. kefyr and C. parapsilosis isolates were susceptible in vitro to the antifungal agents tested, while 1 in 6 C. glabrata isolates showed resistance to azole drugs; all strains were susceptible to nistatine. In pregnant women, C. albicans was the yeast most frequently isolated from vaginal exudates; it continues to be highly susceptible to antifungal drugs. Azole resistance was detected only among C. glabrata isolates. Identification to the species level is recommended, specially in cases of treatment failure and recurrent or chronic infection.
authors.affiliation: Carrera de Especialización en Bacteriología, Escuela de Graduados, Facultad de Farmacia y Bioquímica, UBA.
authors.forename: M
authors.initials: M
authors.lastname: García Heredia
authors.forename: S D
authors.initials: SD
authors.lastname: García
authors.forename: E F
authors.initials: EF
authors.lastname: Copolillo
authors.forename: M
authors.initials: M
authors.lastname: Cora Eliseth
authors.forename: A D
authors.initials: AD
authors.lastname: Barata
authors.forename: C A
authors.initials: CA
authors.lastname: Vay
authors.forename: R A
authors.initials: RA
authors.lastname: de Torres
authors.forename: N
authors.initials: N
authors.lastname: Tiraboschi
authors.forename: A M R
authors.initials: AM
authors.lastname: Famiglietti
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D001118:Argentina / Q000453:epidemiology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology* / Q000382:microbiology; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents