[Extracellular matrix of xenogenic femoral fascia for the repair of renal trauma].
OBJECTIVE
To study the effect of extracellular matrix of xenogenic femoral fascia in repair of renal trauma.


METHODS
Twelve adult dogs were used and randomly assigned to 6 groups, and the animals were sacrificed separately in 1 and 2 weeks 1,2,4 and 8 months after renal repair operations. The examinations of blood and urine routine, blood urea nitrogen and creatinine, electrolyte and serum renin were performed before and after operations at various times. The creatinine clearances of affected and contralateral normal kidneys were evaluated before death and the local areas of renal repair were studied by light and electron microscopy.


RESULTS
Bleeding was stopped completely after the entire patch was sutured, and only mild adhesions to around tissues were found in various times after operations. As time passed, the repair patch was replaced by smooth neocapsule like normal renal capsule.


CONCLUSIONS
Extracellular matrix of xenogenic femoral fascia might be an ideal tissue engineering material for renal repair.
Huang
Guang-lin
GL
Department of Urology, Peking University People's Hospital, Beijing 100044, China. huanggl20032003@yahoo.com
Wang
Xiao-feng
XF
Liu
Liu
L
Li
Gui-zhong
GZ
Wang
Jian-wei
JW
Man
Li-bo
LB
Hu
Jie
J
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004573:Electrolytes / Q000097:blood; D005109:Extracellular Matrix / Q000502:physiology / Q000637:transplantation*; D005205:Fascia / Q000502:physiology; D005260:Female; D007668:Kidney / Q000293:injuries / Q000601:surgery*; D008297:Male; D019736:Prostheses and Implants; D011897:Random Allocation; D012083:Renin / Q000097:blood; D023822:Tissue Engineering / Q000379:methods*
D004573:Electrolytes; D003404:Creatinine; D012083:Renin