Prenatal detection of microtia by MRI in a fetus with trisomy 22.
Trisomy 22 is a rare chromosomal abnormality infrequently detected prenatally. External ear abnormalities, in particular microtia, are often associated with trisomy 22, but prenatal detection of microtia has not been reported in association with trisomy 22. We report a fetus with trisomy 22, with fetal MRI findings of microtia, craniofacial dysmorphism, and polygyria. Fetal MRI is a useful tool for auricular assessment and might have utility in the prenatal detection of chromosomal abnormalities, especially among fetuses with structural anomalies.
Milic
Andrea
A
Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, Canada.
Blaser
Susan
S
Robinson
Ashley
A
Viero
Sandra
S
Halliday
William
W
Winsor
Elizabeth
E
Toi
Ants
A
Thomas
Micki
M
Chitayat
David
D
D001344:Autopsy; D002892:Chromosomes, Human, Pair 22; D004431:Ear, External / Q000002:abnormalities*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis*