High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.
Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals.
Tomlinson
Ian D
ID
The Department of Chemistry, Vanderbilt University, Nashville, TN 37235-1822, USA. iand@femto.cas.vanderbilt.edu
Mason
John N
JN
Blakely
Randy D
RD
Rosenthal
Sandra J
SJ
D019921:Biotinylation; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D045663:Quantum Dots
D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D004298:Dopamine