title: Obliterative bronchiolitis in a patient with myelodysplastic syndrome before bone marrow transplantation.
abstract: Obliterative bronchiolitis (OB) is known to result from many causes, such as post-bone marrow transplantation, autoimmune and infectious causes, and from drugs. We report a 16-year-old female patient who was diagnosed with myelodysplastic syndrome (MDS) and referred for pulmonary evaluation prior to bone marrow transplantation (BMT). Her chief complaints were progressive cough and dysponea. Her radiological and pulmonary function tests were highly suggestive of advanced OB, which was confirmed by a lung biopsy. She eventually died despite steroid therapy. The possible aetiology of OB in this patient is discussed, but, to our knowledge, this is the first case report of OB associated with MDS.
authors.affiliation: Department of Medicine, King Faisal Specialist Hospital & Research Center, MBC 46, Riyadh 11211, Riyadh, Saudi Arabia. mobeireek@yahoo.com
authors.forename: Abdullah
authors.initials: A
authors.lastname: Mobeireek
authors.forename: Fahad
authors.initials: F
authors.lastname: Al-Mohareb
authors.forename: Fouad
authors.initials: F
authors.lastname: Al-Dayel
authors.forename: Suliman
authors.initials: S
authors.lastname: Al-Gazlan
authors.forename: Hail
authors.initials: H
authors.lastname: Alabdely
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khalid
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D001989:Bronchiolitis Obliterans / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D011241:Prednisone