Diversity of 26-locus Y-STR haplotypes in a Nepalese population sample: isolation and drift in the Himalayas.
Twenty-six Y-chromosomal short tandem repeat (STR) loci were amplified in a sample of 769 unrelated males from Nepal, using two multiplex polymerase chain reaction (PCR) assays. The 26 loci gave a discriminating power of 0.997, with 59% unique haplotypes, and the highest frequency haplotype occurring 12 times. We identified novel alleles at four loci, microvariants at a further two, and nine examples of amelogenin-Y deletions (1.2%). Comparison with a similarly sized Bhutanese sample typed with the same markers suggested histories of isolation and drift, with drift having a greater effect in Bhutan. Extended (11-locus) haplotypes for the Nepalese samples have been submitted to the Y-STR Haplotype Reference Database (YHRD).
Parkin
Emma J
EJ
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
Kraayenbrink
Thirsa
T
Opgenort
Jean Robert M L
JR
van Driem
George L
GL
Tuladhar
Nirmal Man
NM
de Knijff
Peter
P
Jobling
Mark A
MA
D053523:Amelogenin / Q000235:genetics; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D009390:Nepal; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences
D053523:Amelogenin