Absence of CYP2B6 promoter -82T>C mutation in Chinese as an additional factor for slow metabolism of drugs commonly used in infections.
He
Ming-Liang
ML
Centre for Emerging Infectious Diseases and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Lin
Ck
C
Tong
Kenneth
K
Xu
Bingying
B
Sung
Joseph Jy
JJ
Kung
Hsiang-Fu
HF
Lee
Shui-Shan
SS
D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D065702:Cytochrome P-450 CYP2B6; D003596:Cytosine; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013941:Thymine
D000890:Anti-Infective Agents; D003596:Cytosine; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D010089:Oxidoreductases, N-Demethylating; D013941:Thymine