title: Recurrence of occult pneumococcal bacteremia by an identical strain in an apparently healthy child.
abstract: This is the first report to describe an apparently healthy girl, who developed recurrent occult bacteremia by the same Streptococcus pneumoniae strain, at 11 and 15 months of age. The two separately isolated organisms were demonstrated to have the identical serotype (type 6B), antibiotic susceptibility (intermediately penicillin-resistant), genotypes of penicillin-binding proteins, and patterns of pulse-field gel electrophoresis. The serum levels of anti-type 6B antibodies showed poor responses after both bacteremic episodes, but other immunological workups did not demonstrate any abnormalities. This case indicates that occult bacteremia may recur due to an identical pneumococcal strain in an immunocompetent infant, and that early introduction of pneumococcal conjugate vaccine is necessary in Japan.
authors.affiliation: Department of Pediatrics, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan. kskmatsu@s4.dion.ne.jp
authors.forename: Kousaku
authors.initials: K
authors.lastname: Matsubara
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukaya
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Meng
authors.initials: M
authors.lastname: Chen
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nigami
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Harigaya
authors.forename: Hideo
authors.initials: H
authors.lastname: Nozaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D016470:Bacteremia / Q000382:microbiology* / Q000517:prevention & control; D001769:Blood / Q000382:microbiology*; D005260:Female; D006801:Humans; D007121:Immunocompetence; D007223:Infant; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000517:prevention & control; D012008:Recurrence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial