Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector.
This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-6.0 [corrected] mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
Wang
Xia
X
Shandong Province Key Laboratory for Applied Technology of Sophisticated Analytical Instruments, Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong 250014, People's Republic of China. xia-w21cn0@163.com
Jiang
Ting
T
Yuan
Jinpeng
J
Cheng
Chuange
C
Liu
Jianhua
J
Shi
Junbo
J
Zhao
Rusong
R
D002849:Chromatography, Gas / Q000379:methods* / Q000592:standards; D004340:Drug Contamination; D005410:Flame Ionization / Q000379:methods* / Q000592:standards; D008832:Microchemistry / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012997:Solvents / Q000032:analysis*; D014835:Volatilization
D004364:Pharmaceutical Preparations; D012997:Solvents