[Expression and significance of gonadotropin-releasing hormone receptor in the endometrium of normal and endometrial cancer uterus].
OBJECTIVE
To investigate the expression of gonadotropin-releasing hormone receptor (GnRH-R) mRNA in the endometrium of normal and endometrial cancer uterus.


METHODS
In situ hybridization was used to detect the expression of GnRH-R mRNA in 23 cases of normal endometrium in hyperplasic phase, 30 cases of normal endometrium in secretory phase, and 30 cases of endometrium from endometrial cancer.


RESULTS
The results showed that GnRH-R mRNA was expressed in the cytoplasm of endometrium of normal and endometrial cancer uterus. There was no expression in the nuclei. There was no significant difference (P > 0.05) in the expression rate between the hyperplasic phase (17%, 4/23) and the secretory phase (17%, 5/30) in normal uterus. The expression rate in endometrial cancer was 40% (12/30), which was significantly higher than normal endometrium (P < 0.05).


CONCLUSIONS
The data demonstrates that GnRH may act directly on endometrium. GnRH-R is highly expressed in the endometrium of endometrial cancer.
Yue
Ying
Y
Department of Obstetrics and Gynecology, First Hospital Jilin University, Changchun 130021, China.
Piao
Jin-xia
JX
Wang
Li-na
LN
Pu
Jian-wen
JW
Gao
Feng-dong
FD
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011966:Receptors, LHRH / Q000235:genetics*
D012333:RNA, Messenger; D011966:Receptors, LHRH