title: Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population.
abstract: This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 normotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
authors.forename: Muhammad Rizwanulhaq
authors.initials: MR
authors.lastname: Khawaja
authors.forename: Fawad
authors.initials: F
authors.lastname: Taj
authors.forename: Usman
authors.initials: U
authors.lastname: Ahmad
authors.forename: Danish
authors.initials: D
authors.lastname: Saleheen
authors.forename: Tazeen
authors.initials: T
authors.lastname: Jafar
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Frossard
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010154:Pakistan / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D017678:Sex Distribution
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III