title: [Study on the extraction of the active component in Atractylode macrocephala with ultrasonic wave technology optimized by the response surface method].
abstract: OBJECTIVE
  To create Atractylode macrocephala inspissation decoction pieces. The effect of ultrasonic wave on extraction of the active components in A. macrocephala was studied in a water solution.
  
  
  METHODS
  The factors including the ratio of material to liquid, ultrasonic power, ultrasonic time, soaking time, particle size etc, were studied. The best extraction method was found through the response surface method.
  
  
  RESULTS
  The best extraction method was found as follows: the granularity of material 0.1 mm, the repetition times of ultrasonic process 3 times, the soaking time before the ultrasonic process 30 min, the ratio of liquid to material 10:1, the soaking time after the ultrasonic process 2.6 h, the time of the ultrasonic wave 15.5 min, the power of the ultrasonic wave 531 W, the rate of reservation of active components 88.5%, the rate of inspissation 1.6.
  
  
  CONCLUSIONS
  The ultrasonic wave can used in the extraction of the active components in A. macrocephala and a model equation that can be used to predict the experiment was get through the response surface method.
authors.affiliation: Pharmaceutical College, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Shi-Yong
authors.initials: SY
authors.lastname: Lu
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Qian
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zou
mesh_terms: D031174:Atractylodes / Q000737:chemistry*; D007783:Lactones / Q000302:isolation & purification*; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000379:methods*; D014465:Ultrasonics
chemical_list: D007783:Lactones; D009822:Oils, Volatile; D011134:Polysaccharides; D012717:Sesquiterpenes; C424802:atractylenolide III