Regenerative and immunomodulatory potential of mesenchymal stem cells.
In the past few years, mesenchymal stem cells (MSCs) have come into the limelight because of their multi-lineage stem cell potential, which retains some aspects of embryonic stem cells, and because of their characteristic immunoregulatory functions exerted on different immune effector cells. The regenerative and immunomodulatory potential of MSCs has been used to support hemopoietic stem cell engraftment; to repair or regenerate damaged or mutated tissues, such as bone, cartilage, myocardial or hepatic tissues; to interfere with neoplastic cell growth by transfecting MSCs with anti-neoplastic molecules; and to modulate autoimmune reactions such as collagenopathies, multiple sclerosis and graft versus host disease. Thus, MSCs appear to be a very promising tool for regenerative and immunoregulatory cell therapy.
Krampera
Mauro
M
Department of Clinical and Experimental Medicine, Section of Haematology, P.le L.A. Scuro 10, 37134 Verona, Italy. mauro.krampera@univr.it
Pasini
Annalisa
A
Pizzolo
Giovanni
G
Cosmi
Lorenzo
L
Romagnani
Sergio
S
Annunziato
Francesco
F
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D010641:Phenotype