Expanding role of AMPK in endocrinology.
Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome.
Kola
Blerina
B
Department of Endocrinology, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, London, EC1M 6BQ, UK.
Boscaro
Marco
M
Rutter
Guy A
GA
Grossman
Ashley B
AB
Korbonits
Márta
M
D055372:AMP-Activated Protein Kinases; D052242:Adiponectin / Q000502:physiology; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D002186:Cannabinoids / Q000096:biosynthesis / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D004703:Endocrine System / Q000502:physiology*; D064429:Fatty Acid Synthases / Q000502:physiology; D054439:Ghrelin; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D007328:Insulin / Q000494:pharmacology; D020738:Leptin / Q000502:physiology; D008687:Metformin / Q000494:pharmacology; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000502:physiology*; D036361:Peptide Hormones / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000378:metabolism; D052243:Resistin / Q000502:physiology; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology; D008063:Thioctic Acid / Q000502:physiology
D052242:Adiponectin; D002186:Cannabinoids; D016207:Cytokines; D054439:Ghrelin; D007028:Hypothalamic Hormones; D007328:Insulin; D020738:Leptin; D009097:Multienzyme Complexes; D036361:Peptide Hormones; D011941:Receptors, Adrenergic; D052243:Resistin; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D008063:Thioctic Acid; D008687:Metformin; D064429:Fatty Acid Synthases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose