title: Novel recombinant norovirus causing outbreaks of gastroenteritis in Santiago, Chile.
abstract: Capsid and polymerase (RdRp) genes of 13 norovirus outbreak strains from Chile were compared. The genes sequences were discordant for five strains, and recombination was confirmed for two of them by amplification of a 1,360-bp gene segment containing a fragment of both genes. These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies.
authors.affiliation: Programa de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Roberto
authors.initials: R
authors.lastname: Vidal
authors.forename: Patricia
authors.initials: P
authors.lastname: Roessler
authors.forename: Verónica
authors.initials: V
authors.lastname: Solari
authors.forename: Jimena
authors.initials: J
authors.lastname: Vollaire
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.forename: David O
authors.initials: DO
authors.lastname: Matson
authors.forename: Nora
authors.initials: N
authors.lastname: Mamani
authors.forename: Valeria
authors.initials: V
authors.lastname: Prado
authors.forename: Miguel L
authors.initials: ML
authors.lastname: O'Ryan
mesh_terms: D001483:Base Sequence; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000821:virology; D002213:Capsid; D036022:Capsid Proteins / Q000235:genetics; D002677:Chile / Q000453:epidemiology; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004196:Disease Outbreaks; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D029322:Norovirus / Q000235:genetics*; D010802:Phylogeny; D011995:Recombination, Genetic
chemical_list: D036022:Capsid Proteins; D012321:DNA-Directed RNA Polymerases