MAgnetic stimulation of the brain increase Na+, K+-ATPase activity decreased by injection of AlCl3 into nucleus basalis magnocellularis of rats.
This article reports here on the influence of the static magnetic fields (MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis (NBM) by intracerebral injection of 5 microl, 1% AlCl3 into the nucleus. Two AKMA micromagnets (M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with "N" polarity facing down to the cranial bones in the vicinity of the pineal gland (PG), immediately after the lesioning of NBM, during the same operation procedure. Ten days after the lesions of NBM, Na, K-ATPase activity on the erythrocyte membranes in the peripheral blood, measured spectrophotometrically, was completely inhibited. Magnetic stimulation (60 mT) of the brain during the 10 days significantly increased Na, K-ATPase activity on the erythrocyte membranes of rats with lesioned NBM. This results suggests that altered by lesions Na, K-ATPase activity in an experimental model of Alzheimer's disease might be ameliorated by magnetic stimulation of the brain.
Jovanova-Nesic
Katica
K
Immunology Research Center Branislav Jankovic, Belgrade, Serbia and Montenegro. nesic@torlakinstitut.com
Eric-Jovicic
Milena
M
Spector
Novera Herbert
NH
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D020532:Basal Nucleus of Meynert / Q000187:drug effects* / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D002712:Chlorides / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D008280:Magnetics; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000254:Sodium-Potassium-Exchanging ATPase