Controlling stem cell proliferation: CKIs at work.
The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.
Bruggeman
Sophia W M
SW
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Lohuizen
Maarten
M
D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
D050756:Cyclin-Dependent Kinase Inhibitor Proteins