title: Comparative neurophysiological study for the diagnosis of mild polyneuropathy in patients with diabetes mellitus and glucose intolerance.
abstract: This article evaluates diagnostic sensitivity of minimal F-wave latency, sural/radial amplitude ratio (SRAR), dorsal sural/radial amplitude ratio (DSRAR), sympathetic skin response (SSR), and R-R interval variability (RRIV) for detecting early polyneuropathy in patients with glucose intolerance and diabetic patients. F-wave latencies were more prolonged in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). SRAR was lower, SSR latency was more prolonged, and RRIV was lower in diabetic patients with abnormal nerve conduction studies than healty controls (p < .001). SSR latency was more prolonged and RRIV was lower in diabetic patients with normal nerve conduction studies than healty controls (p < .01, p < .05, respectively). DSRAR was lower in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). DSRAR was also lower in patients with glucose intolerance than control subjects (p < .01). DSRAR was the most sensitive and specific test in either of diabetic patients with normal nerve conduction studies (sensitivity 66%, specificity 90%) and diabetic patients with abnormal nerve conduction studies (sensitivity 100%, specificity 90%). DSRAR is the most reliable method for detection of early nerve pathology. Patients with glucose intolerance might have subclinical neuropathy that can be demonstrated with DSRAR analysis.
authors.affiliation: Trakya University Medical Faculty, Neurology Department, Edirne, Turkey. nildaturgut@hotmail.com
authors.forename: Nilda
authors.initials: N
authors.lastname: Turgut
authors.forename: Sibel
authors.initials: S
authors.lastname: Güldiken
authors.forename: Kemal
authors.initials: K
authors.lastname: Balci
authors.forename: Armagan
authors.initials: A
authors.lastname: Tugrul
authors.forename: Ufuk
authors.initials: U
authors.lastname: Berberoglu
authors.forename: Betül Ugur
authors.initials: BU
authors.lastname: Altun
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D018149:Glucose Intolerance / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D009482:Neurophysiology / Q000379:methods*; D011115:Polyneuropathies / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects