title: Spontaneous splenic infarction associated with sumatriptan use.
abstract: Triptans are specific agonists of the serotonergic 5-HT(1B/1D) receptors that have increasingly been used in the treatment of migraine and cluster headaches. Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use. We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.
authors.affiliation: Department of Internal Medicine, Western Pennsylvania Hospital, Temple University Program, Pittsburgh, PA 15224, USA. anjuarora27@hotmail.com
authors.forename: Anju
authors.initials: A
authors.lastname: Arora
authors.forename: Sandeep
authors.initials: S
authors.lastname: Arora
mesh_terms: D015984:Causality; D002536:Cerebral Arteries / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D010455:Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B / Q000187:drug effects / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000009:adverse effects; D013154:Spleen / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D013157:Splenic Artery / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D013159:Splenic Infarction / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D018170:Sumatriptan / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000009:adverse effects
chemical_list: D010455:Peptides; D044302:Receptor, Serotonin, 5-HT1B; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D018170:Sumatriptan