Reversible tremor, myoclonus, and fasciculations associated with topiramate use for migraine.
OBJECTIVE
To report a patient with tremor, multifocal myoclonus, and fasciculations, possibly induced by the antiepileptic drug topiramate.


METHODS
A 46-year-old woman with frequent episodes of migraine without aura that were not controlled with other prophylactic drug, developed a reversible clinical picture of postural tremor, multifocal myoclonus, weight loss, amyotrophia, and fasciculations after exposure to topiramate. These symptoms disappeared after topiramate withdrawal.


CONCLUSIONS
Tremor, myoclonus, and fasciculations should be considered as a possible adverse effect of topiramate.
Alonso-Navarro
Hortensia
H
Servicio de Neurología, Hospital Virgen de la Concha, Zamora, Spain.
Jiménez-Jiménez
Félix Javier
FJ
D005207:Fasciculation / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology; D009207:Myoclonus / Q000139:chemically induced* / Q000503:physiopathology; D000077236:Topiramate; D014202:Tremor / Q000139:chemically induced* / Q000503:physiopathology
D000077236:Topiramate; D005632:Fructose