Switch-peptides to trigger the peptide guided assembly of poly(ethylene oxide)-peptide conjugates into tape structures.
A strong beta-sheet forming peptide was conjugated to PEO and utilized to guide the structure formation process toward well-defined, tape-like structures with millimeters in length, about 2 mum width, and approximately 50 nm height. The aggregation tendency of the peptide was temporarily suppressed for ease of synthesis by the integration of multiple switch-peptide defect segments into the peptide backbone. A subsequent rearrangement in the defects re-establishes the native peptide backbone and triggers the assembly by switching the aggregation properties on.
Hentschel
Jens
J
Max Planck Institute of Colloids and Interfaces, MPI KGF Golm, 14424 Potsdam, Germany.
Krause
Eberhard
E
Börner
Hans G
HG
D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
D010455:Peptides; D011092:Polyethylene Glycols