Quantification by HPLC-MS/MS of atropine in human serum and clinical presentation of six mild-to-moderate intoxicated atropine-adulterated-cocaine users.
An unexpectedly high number of initially suspected cocaine-intoxicated patients was presented to a general hospital in Lelystad, The Netherlands. Based on the unusual toxidram rate of not fitting cocaine intoxication, the suspicion of co-presence of an anticholinergic agent was raised. A newly developed HPLC-MS/MS analytical method revealed the presence of 10% atropine in a cocaine sample retrieved and subsequently in the sera of 6 intoxicated patients.
Boermans
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Department of Hospital Pharmacy, IJsselmeerziekenhuizen, Lelystad, The Netherlands. p.boermans@ijsselmeerziekenhuizen.nl
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D000328:Adult; D001285:Atropine / Q000097:blood* / Q000506:poisoning*; D018680:Cholinergic Antagonists / Q000097:blood* / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D019970:Cocaine-Related Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009426:Netherlands
D018680:Cholinergic Antagonists; D001285:Atropine