title: Corneal perforation due to severe peripheral ulcerative keratitis in Crohn disease.
abstract: OBJECTIVE
  To describe corneal perforation secondary to severe peripheral ulcerative keratitis (PUK) in a patient with Crohn disease.
  
  
  METHODS
  Interventional case report.
  
  
  RESULTS
  A 72-year-old male with biopsy-proven Crohn disease presented with reduced vision, PUK, and corneal perforation in the right eye. Despite initial treatment with intravenous methylprednisolone and a conjunctival flap, a tectonic sectorial penetrating keratoplasty was required to preserve the globe and achieve a good visual result.
  
  
  CONCLUSIONS
  Crohn disease may be associated with severe PUK leading to corneal perforation. Tectonic corneal grafting combined with treatment of the underlying systemic disease was associated with a favorable outcome.
authors.affiliation: Oxford Eye Hospital, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, United Kingdom. mhtan@hotmail.com
authors.forename: Mei Hong
authors.initials: MH
authors.lastname: Tan
authors.forename: Simon D M
authors.initials: SD
authors.lastname: Chen
authors.forename: Adrian
authors.initials: A
authors.lastname: Rubinstein
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Bron
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000601:surgery; D003320:Corneal Ulcer / Q000209:etiology* / Q000601:surgery; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012422:Rupture, Spontaneous; D013524:Surgical Flaps
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone