Subacute thrombosis after coronary stenting occurring with resistance to ticlopidine.
A 79-year-old man underwent stent implantation from the proximal site to the left main trunk with one bare metal stent after rotation atherectomy. He received 200 mg/day ticlopidine and 200 mg/day aspirin from 2 days pre-stenting. Subacute thrombosis occurred 5 days after coronary stenting. We performed a test of platelet aggregation one month after the commencement of dual antiplatelet therapy and the test showed no response to ticlopidine in this case. An increased dose of ticlopidine was not effective for suppressing platelet aggregation. We report a case of subacute stent thrombosis which is related to ticlopidine resistance.
Fuchigami
Shunichiro
S
Division of Cardiology, Kumamoto Central Hospital, Tainoshima.
Oshima
Shuichi
S
Hokimoto
Seiji
S
Noda
Katsuo
K
Fukushima
Hironobu
H
Yoshida
Toshiaki
T
Takushi
Yukiko
Y
Ogawa
Hisao
H
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017225:Atherectomy, Coronary; D003328:Coronary Thrombosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D004351:Drug Resistance; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015607:Stents / Q000009:adverse effects*; D015912:Thrombolytic Therapy; D013988:Ticlopidine / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine