An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia.
Manganese superoxide dismutase (MnSOD) protects cells against oxidative stress by eliminating superoxides. Hypothetically, decreased MnSOD levels in cancer might lead to increased oxidative stress and, thus, to increased sensitivity of cells to chemotherapy agents. Eighty-nine patients with acute myeloid leukemia (AML) were analyzed for a functional C to T polymorphism of MnSOD, which could potentially lead to decreased enzyme concentrations inside mitochondria. A significant survival advantage (p=0.02) was observed for those AML patients carrying T-containing alleles of MnSOD compared to the patients with the CC genotype. These preliminary results may indicate an important role for genetic factors regulating the cellular redox state in determining the outcome of leukemia chemotherapy.
Koistinen
Pirjo
P
Department of Internal Medicine, University of Oulu, Finland. pirjo.koistinen@oulu.fi
Ruuska
Satu
S
Saily
Marjaana
M
Kakko
Sakari
S
Siitonen
Pauliina
P
Siitonen
Timo
T
Savolainen
Markku J
MJ
Kinnula
Vuokko L
VL
Savolainen
Eeva-Riitta
ER
D000208:Acute Disease; D001483:Base Sequence; D002374:Catalase / Q000235:genetics; D017931:DNA Primers; D005979:Glutathione Peroxidase / Q000235:genetics; D006801:Humans; D007700:Kinetics; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000201:enzymology* / Q000401:mortality; D008928:Mitochondria / Q000201:enzymology; D010084:Oxidation-Reduction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis; D016896:Treatment Outcome
D017931:DNA Primers; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase