title: A flexible approach for the preparation of substituted benzazepines: application to the synthesis of tolvaptan.
abstract: A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.
authors.affiliation: Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cordero-Vargas
authors.forename: Béatrice
authors.initials: B
authors.lastname: Quiclet-Sire
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D000077602:Tolvaptan
chemical_list: D001552:Benzazepines; D000077602:Tolvaptan