[Preventive effects of teprenone on gastric mucosal lesions induced by Helicobacter pylori in mice].
OBJECTIVE
To determine the preventive effect of teprenone on gastric mucosal injury induced with Helicobacter pylori concentrated culture supernatant (CCS) in Balb/c mice.


METHODS
Gastric mucosa lesions were induced with intragastrical administration of Helicobacter pylori CCS. Sixty Balb/c mice were divided into control group, injury group, sucralfate protective group and teprenone protective group. Mice of two protective groups were pretreated with sucralfate or teprenone respectively before induction of gastric mucosa lesions. Mucosal changes were assessed by microscopic examination, quantitative histology and electron microscopy.


RESULTS
Histologic and ultrastructural lesions in protective groups were less severe than those in injury group. Epithelial damage scoring (EDS) of teprenone protective group (1.68 +/- 0.69) and sucralfate protective group (1.72 +/- 0.73) were significantly decreased than injury group (2.47 +/- 0.58, P < 0.05).


CONCLUSIONS
Teprenone as well as sucralfate reduces gastric mucosal lesions induced by Helicobacter pylori CCS in mice.
Yang
Gui-bin
GB
Department of Gastroenterology, Aerospace Medical School of Peking University, Beijing 100039, China.
Hu
Fu-lian
FL
Mu
Fang-hong
FH
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004224:Diterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D016481:Helicobacter Infections / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D016480:Helicobacter pylori / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D013392:Sucralfate / Q000494:pharmacology / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D013392:Sucralfate; C031049:geranylgeranylacetone