title: Cerebral palsy due to chromosomal anomalies and continuous gene syndromes.
abstract: When cerebral palsy is defined as a disorder of movement and posture that is due to nonprogressive disturbances that occur in the developing fetal and infant brain, a significant proportion-up to 10%--is the consequence of chromosomal anomalies and continuous gene syndromes. Abnormalities of chromosomes are constitutional or acquired. Acquired chromosomal abnormalities develop postnatally, affect only one clone of cells, and are implicated in the evolution of neoplasia. Constitutional abnormalities develop during gametogenesis or early embryogenesis and affect a significant portion of the subject's cells.
authors.affiliation: Division of Pediatric Neurology, University of California, Los Angeles, USA. jhansmenk@aol.com
authors.forename: John H
authors.initials: JH
authors.lastname: Menkes
authors.forename: Laura
authors.initials: L
authors.lastname: Flores-Sarnat
mesh_terms: D002547:Cerebral Palsy / Q000175:diagnosis / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D007231:Infant, Newborn; D013577:Syndrome