title: Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.
abstract: A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan. tamamura.mr@tmd.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tamamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Masuno
authors.forename: Satoko
authors.initials: S
authors.lastname: Mizokami
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Wang
authors.forename: John O
authors.initials: JO
authors.lastname: Trent
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakashima
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Peiper
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008970:Molecular Weight; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D009842:Oligopeptides; D010456:Peptides, Cyclic; D019718:Receptors, CXCR4; C116977:T140 peptide