Effect of low-choline diet and ethanol on electroconductivity of tissues in CBA mice.
We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of impedance frequency components. Morphological changes in the adrenal glands were more pronounced than in the spleen and consisted in delipidation of the adrenocortical cell cytoplasm in the zona fasciculata and increase in cell heterogeneity in the zona reticularis of animals of different groups. The observed morphological and electrophysiological changes can serve as a criterion of the severity of stress. The method for a quantitative study of tissue electroconductivity is informative for evaluation of the effects of internal and external factors on organs and tissues.
Tornuev
Yu V
YV
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Nepomnyashchikh
L M
LM
Koldysheva
E V
EV
D000302:Adrenal Cortex / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology; D002794:Choline / Q000378:metabolism / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism; D004032:Diet; D004594:Electrophysiology / Q000379:methods; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol; D002794:Choline