title: Impact of topical minocycline with third molar surgery on clinical recovery and health-related quality of life outcomes.
abstract: OBJECTIVE
  Compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients treated with or without topical minocycline at surgery.
  
  
  METHODS
  Sixty-three patients at least 18 years of age with all 4 third molars below the occlusal plane were treated with topical minocycline during third molar surgery. Topical minocycline (1.0 mg in bioresorbable polyglycolide-co-dl-lactide [PGLA] sustained-release microspheres) was placed sequentially in bony defects after removal of lower third molars. Clinical and health-related quality of life (HRQOL) outcomes of these patients postsurgery were compared with those of a nonconcurrent control group (n = 60 patients) who did not receive antibiotics. The control group was selected using the same criteria and treated under the same surgical protocol as the antibiotic group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics.
  
  
  RESULTS
  The 63 patients in the minocycline group were treated at 4 clinical centers. The incidence of delayed clinical recovery, defined as a postsurgery visit with treatment, was significantly lower in the minocycline group compared with the control group. In the minocycline group, 10% had 1 postsurgery visit with treatment; no patient had 2 visits. In the control group without antibiotics, 28% had at least 1 postsurgery visit with treatment (P = .01) and 13% had at least 2 postsurgery visits with treatment. Recovery time to "no" or "little trouble" with chewing and mouth opening was significantly improved in the minocycline group (P < .05).
  
  
  CONCLUSIONS
  Administration of topical minocycline with third molar surgery may improve clinical and HRQOL recovery in healthy adult patients with all 4 third molars below the occlusal plane, a presenting characteristic that has been suggested as a risk factor for delayed recovery.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Stavropoulos
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Shugars
authors.forename: Ceib
authors.initials: C
authors.lastname: Phillips
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Conrad
authors.forename: Phillip T
authors.initials: PT
authors.lastname: Fleuchaus
authors.forename: Raymond P
authors.initials: RP
authors.lastname: White
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage*; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000517:prevention & control; D011788:Quality of Life; D020127:Recovery of Function / Q000187:drug effects; D018709:Statistics, Nonparametric; D014081:Tooth Extraction / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D008911:Minocycline