title: Is Saccharomyces cerevisiae apoptotic cell death associated with gene transfer?
abstract: Programmed cell death in unicellular organisms is difficult to account for in evolutionary terms. In the budding yeast, Saccharomyces cerevisiae, existence of several morphological and biochemical features of apoptosis has been described, and genes responsible for execution of the death program have been identified. It is here suggested that apoptosis of yeast cells could provide direct benefit to the genes of the dying cells, by facilitating DNA transfer to surrounding cells. The biochemical details of yeast apoptotic death are considered in light of a gene transfer hypothesis.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. amnon.koren@weizmann.ac.il
authors.forename: Amnon
authors.initials: A
authors.lastname: Koren
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D020169:Caspases / Q000502:physiology; D022761:Gene Transfer, Horizontal / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D020169:Caspases; C456272:MCA1 protein, S cerevisiae