title: The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals.
abstract: Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA (1.6 x 10(8) IU/mL), increase from 19-39 IU/mL to 50-100 IU/mL. We found that, in the presence of 1.6-2.2 x 10(8) IU of B19 DNA/mL in B19-seronegative recipients, a pooled-plasma B19 IgG level of 59.5 IU/mL is insufficient to prevent B19 transmission and subsequent seroconversion. These data should lead to improvements in the assessment of blood-product safety.
authors.affiliation: Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland, Maynooth, County Kildare, Ireland. sean.doyle@nuim.ie
authors.forename: Sean
authors.initials: S
authors.lastname: Doyle
authors.forename: Amanda
authors.initials: A
authors.lastname: Corcoran
mesh_terms: D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology*; D004279:DNA, Viral; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D010322:Parvoviridae Infections / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D016732:Parvovirus B19, Human / Q000276:immunology*; D011358:Product Surveillance, Postmarketing
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M