[The protective effect of oral magnesium supplement on noise-induced hearing loss].
OBJECTIVE
We investigated the beneficial effect of magnesium in the prevention of noise-induced cochlear damage in guinea pigs by transient evoked otoacoustic emissions (TEOAE).


METHODS
Thirty-nine guinea pigs with normal auropalpebral reflex were randomly divided into control (n=20) and study (n=19) groups. All the animals were subjected to wide-band noise standardized at a mean of 98+/-2 dB for 16 hours a day for 10 days in a sound isolated cabin. The study animals received 39 mmol/l MgCl2 throughout the study period starting from 15 days before noise exposure. Otomicroscopic examination, auditory brain stem response (ABR) and TEOAE measurements were performed before and after noise exposure. Tympanometric measurements were performed to eliminate possible middle ear pathologies.


RESULTS
Although the mean TEOAE response and reproducibility values showed significant decreases after noise application in the control group (p<0.001), they were not affected significantly in magnesium-treated animals. Post-exposure mean TEOAE response and reproducibility values significantly differed between the two groups (p<0.001). Noise-induced elevations in ABR thresholds were significant in both groups (p<0.001); however, it was noted that hearing levels were better preserved in the study group.


CONCLUSIONS
Our data suggest that oral magnesium intake may be beneficial in the prevention of cochlear damage in noise-induced hearing loss.
Yildirim
Cetin
C
Department of Otolaryngology, Medicine Faculty of Trakya University, Edirne, Turkey.
Yağiz
Recep
R
Uzun
Cem
C
Taş
Abdullah
A
Bulut
Erdoğan
E
Karasalihoğlu
Ahmet
A
D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control*; D015636:Magnesium Chloride / Q000008:administration & dosage*; D017084:Otoacoustic Emissions, Spontaneous
D015636:Magnesium Chloride