title: Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds.
abstract: Silver products have been used for thousands of years for their beneficial effects, often for hygiene and in more recent years as antimicrobials on wounds from burns, trauma, and diabetic ulcers. Silver sulfadiazine creams (Silvazine and Flamazine) are topical ointments that are marketed globally. In recent years, a range of wound dressings with slow-release Ag compounds have been introduced, including Acticoat, Actisorb Silver, Silverlon, and others. While these are generally accepted as useful for control of bacterial infections (and also against fungi and viruses), key issues remain, including importantly the relative efficacy of different silver products for wound and burn uses and the existence of microbes that are resistant to Ag+. These are beneficial products needing further study, although each has drawbacks. The genes (and proteins) involved in bacterial resistance to Ag have been defined and studied in recent years.
authors.affiliation: Department of Microbiology and Immunology, University of Illinois, 835 S. Wolcott Ave., Chicago, IL 60612-7344, USA. Simon@uic.edu
authors.forename: Simon
authors.initials: S
authors.lastname: Silver
authors.forename: Le T
authors.initials: le T
authors.lastname: Phung
authors.forename: Gregg
authors.initials: G
authors.lastname: Silver
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002056:Burns / Q000188:drug therapy; D004202:Disinfectants / Q000494:pharmacology* / Q000627:therapeutic use; D052978:Disk Diffusion Antimicrobial Tests; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D009779:Occlusive Dressings; D018030:Silver Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004202:Disinfectants; D018030:Silver Compounds