[Oxidative homeostasis of organism during mechanical jaundice].
The aim of our research was the study of the intensity of the oxidative homeostasis of the organism during the mechanical jaundice. From the results of our study it follows that during the cholestasis the violation of the balance between pro-and antioxidant blood system takes place in the patient's blood. The latter is manifested in the blood EPR spectrum in the considerable increase (about 47%) of the intensity of the EPR oxidated ceruloplazmin signal, in the decrease of the intensity of the EPR signal Fe3+ transferin (on 16%), in the increase of the contents of promoters of the free-radical oxidation of ions Fe2+ and Mn2+. As it follows from the results of our researches, the considerable increase of the contents of the free nitrogen oxide is observed during the mechanical jaundice. So it can be concluded, that the intensification of the free-radical processes and the emanation of the protective antioxidant enzyme systems takes place in the organism. Consequently, activation of the peroxide oxidation processes takes place, which disrupts cell membrane integrity and leads to the development of the irreversible tissue injuries.
Asatiani
G A
GA
Tokhadze
L T
LT
Gopodze
L N
LN
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002570:Ceruloplasmin / Q000032:analysis; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000097:blood; D041781:Jaundice, Obstructive / Q000378:metabolism*; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D014168:Transferrin / Q000032:analysis
D000975:Antioxidants; D005609:Free Radicals; D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin; D008274:Magnesium