Primary synovial sarcoma of the lung.
A 45 -year-old woman presented chest pain and a well-defined oval shaped mass on a chest radiograph. A malignant pulmonary tumor was suspected and a right pneumonectomy was performed. The tumor measured about 13 x 12 cm, was pale-yellow in color and soft in texture. Histologically, it had round to oval and spindle-shaped cells with minimal cytoplasm, hyperchromatic nuclei, inconspicuous mitoses and only slight fibrous stroma. Immunohistochemically, the tumor cells were positive for vimentin, CD 99, BCL-2 protein and EMA. The reverse transcriptase-polymerase chain reaction (RT-PCR), using RNA extracted from fresh-frozen tissue, demonstrated SYT/SSX-2 fusion transcripts, confirming the diagnosis of synovial sarcoma.
Zamarrón
Carlos
C
Division of Respiratory Medicine, Hospital Clínico Universitario, Santiago, Spain.
Abdulkader
Ihab
I
Alvarez
Uxio Calvo
UC
Barón
Franciisco Javiver
FJ
Prim
Jose Maria Garcia
JM
Ledo
Ramiro Ledo Andio
RL
Forteza
Jeronimo
J
D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
D014408:Biomarkers, Tumor