title: Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy.
abstract: The aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32 weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8-198.8) U/L at preconception to 111.1 (85.3-179.9) U/L (p<0.01) at 32 weeks and 100.4 (54.7-171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.
authors.affiliation: Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, Reus, Spain.
authors.forename: Natàlia
authors.initials: N
authors.lastname: Ferré
authors.forename: Jordi
authors.initials: J
authors.lastname: Camps
authors.forename: Joan
authors.initials: J
authors.lastname: Fernández-Ballart
authors.forename: Victoria
authors.initials: V
authors.lastname: Arija
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Murphy
authors.forename: Judit
authors.initials: J
authors.lastname: Marsillach
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D001205:Ascorbic Acid / Q000494:pharmacology; D019587:Dietary Supplements; D005260:Female; D005306:Fertilization; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects; D011247:Pregnancy / Q000097:blood*; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D014810:Vitamin E; D043303:Aryldialkylphosphatase; D001205:Ascorbic Acid