A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla.
A novel compound, rodgersinol (1), was isolated from the aerial parts of Rodgersia podophylla and its structure was elucidated with various spectroscopic methods. Rodgersinol (1) exhibited the significant inhibitory effects on iNOS and COX-2 expressions in LPS-activated macrophages.
Chin
Young-Won
YW
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea.
Park
Eun Young
EY
Seo
Seung-Yong
SY
Yoon
Kee-Dong
KD
Ahn
Mi-Jeong
MJ
Suh
Young-Ger
YG
Kim
Sang Geon
SG
Kim
Jinwoong
J
D000818:Animals; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D031995:Saxifragaceae / Q000737:chemistry*
D004791:Enzyme Inhibitors; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2