title: Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis.
abstract: Extracellular matrix metalloproteinase inducer (EMMPRIN) was examined on bronchoalveolar lavage fluids (BALFs) and lung tissue from patients with fibrosis (usual interstitial pneumonia-idiopathic pulmonary fibrosis [UIP-IPF], n = 15; diffuse parenchymal lung diseases without IPF characteristics on computerized tomography scan, n = 8) and without fibrosis (n = 6). In UIP-IPF, EMMPRIN staining was increased in areas of fibrosis, mainly in macrophages and in epithelial cells. EMMPRIN was also found in the extracellular medium with significant levels in patients with lung fibrosis compared to subjects without fibrosis. Moreover, macrophages from patients with lung fibrosis spontaneously produce EMMPRIN. These findings show that EMMPRIN is increased in lung fibrosis.
authors.affiliation: INSERM U620, Université de Rennes 1, Rennes cedex, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Guillot
authors.forename: Philippe
authors.initials: P
authors.lastname: Delaval
authors.forename: Graziella
authors.initials: G
authors.lastname: Brinchault
authors.forename: Sylvie
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: Alexandra
authors.initials: A
authors.lastname: Depince
authors.forename: Hervé
authors.initials: H
authors.lastname: Lena
authors.forename: Bertrand
authors.initials: B
authors.lastname: Delatour
authors.forename: Vincent
authors.initials: V
authors.lastname: Lagente
authors.forename: Corinne
authors.initials: C
authors.lastname: Martin-Chouly
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051926:Basigin / Q000032:analysis / Q000378:metabolism*; D015153:Blotting, Western; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D051926:Basigin