Spatial dynamics of population activities at S1 after median and ulnar nerve stimulation revisited: an MEG study.
In a number of studies, magnetoencephalography (MEG) has been successfully employed in localizing cortical neural population activities after stimulation of peripheral nerves. Little attention has been paid, however, to the spatiotemporal dynamics of these activations within the primary somatosensory cortex (SI). Here we report on the activation sequence at the right SI after left median and ulnar nerve stimulation. The results show that at least three macroscopically separable sources within or near SI are activated within 100 ms after the stimulus, corresponding to the somatosensory evoked field (SEF) deflections N20m, P35m and P60m. As P60m was localized significantly more posteriorly and also tended to be deeper than the two earlier deflections, its underlying source may be more extensive than during N20m and P35m, and it may get contribution from the postcentral gyrus and sulcus, possibly Brodmann areas 1 and 2. The source separation between the neural populations activated by the 2 nerves was 12 mm during N20m, 6 mm during P35m and 4 mm during P60m. Thus, at longer latencies, the centers of gravity of the activations were closer to each other for the 2 nerves. We argue that this reflects spreading of the activation with time from the site of initial excitation to encompass larger and more overlapping neural populations at longer latencies.
Huttunen
Juha
J
BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, FIN-00029 Helsinki, Finland. juha.huttunen@pp2.inet.fi
Komssi
Soile
S
Lauronen
Leena
L
D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D011153:Population; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014459:Ulnar Nerve / Q000502:physiology*