Jacaranone glycosides from Senecio scandens.
Bioassay-guided fractionation of the ethanol extract of Senecio scandens led to the isolation of four new compounds 1-4. These compounds were obtained as tautomeric mixture of alpha/beta epimers, but their structures were confirmed unambiguously by 1D and 2D NMR spectra and LC NMR technology. 1H NMR spectra of pure 1alpha and 1beta were furnished by HPLC NMR technology. Compounds 1-4 exhibited moderate cytotoxicities against five tumor cell lines.
Tian
Xiao-Yan
XY
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Peking Union Medicinal College, and Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
Wang
Ying-Hong
YH
Yang
Qing-Yun
QY
Liu
Xin
X
Fang
Wei-Shuo
WS
Yu
Shi-Shan
SS
D016227:Benzoquinones; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D011809:Quinones / Q000737:chemistry* / Q000302:isolation & purification*; D012674:Senecio / Q000737:chemistry*
D016227:Benzoquinones; D006027:Glycosides; D011809:Quinones; C013077:jacaranone