title: Synthesis and biological evaluation of 5-arylamino-1H-benzo[d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation.
abstract: 5-Arylamino-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activities on the proliferation of human umbilical vein endothelial cells (HUVECs) and the smooth muscle cells (SMCs). Among them, several 1H-benzo[d]imidazole-4,7-diones exhibited the selective antiproliferative activity on the HUVECs. Further mechanistic study revealed that the inhibitory effect of one representative 1H-benzo[d]imidazole-4,7-dione 2b on HUVEC proliferation was mediated by the activation of p38 signaling pathway in the HUVECs.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.
authors.forename: Kwang-Hoe
authors.initials: KH
authors.lastname: Chung
authors.forename: Sung-Yu
authors.initials: SY
authors.lastname: Hong
authors.forename: Hea-Jung
authors.initials: HJ
authors.lastname: You
authors.forename: Rae-Eun
authors.initials: RE
authors.lastname: Park
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D020935:MAP Kinase Signaling System / Q000187:drug effects; D015394:Molecular Structure
chemical_list: D007093:Imidazoles