title: Monozygotic twins with Marfan's syndrome and ascending aortic aneurysm.
abstract: Marfan's syndrome is a hereditary connective tissue disease, in which cardiovascular abnormalities (especially aortic root dilatation) are the most important cause of morbidity and mortality. In this report, we describe two 24-year-old twins, with a history of surgery for lens subluxation and severe cardiovascular manifestations secondary to Marfan's syndrome. One of the twins suffered a type A aortic dissection, which required replacement of the ascending aorta, and the other twin had an aneurysmal dilatation of the ascending aorta (46mm) and was prescribed medical treatment with atenolol and periodic controls to detect the presence of a critical diameter (50mm) that would indicate the need for prophylactic surgery.
authors.affiliation: Division of Cardiology and Cardiovascular Surgery, Hospitales del Gobierno de la Ciudad de Buenos Aires Bernardino Rivadavia and Cosme Argerich, Buenos Aires, Argentina. jredruello@hotmail.com.ar
authors.forename: Héctor Jorge
authors.initials: HJ
authors.lastname: Redruello
authors.forename: Tomas Francisco
authors.initials: TF
authors.lastname: Cianciulli
authors.forename: Eduardo Fernandez
authors.initials: EF
authors.lastname: Rostello
authors.forename: Barbara
authors.initials: B
authors.lastname: Recalde
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Lax
authors.forename: Victorio Próspero
authors.initials: VP
authors.lastname: Picone
authors.forename: Sandro Mario
authors.initials: SM
authors.lastname: Belforte
authors.forename: Horacio Alberto
authors.initials: HA
authors.lastname: Prezioso
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000209:etiology; D001011:Aorta / Q000000981:diagnostic imaging* / Q000473:pathology; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging* / Q000209:etiology; D001262:Atenolol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D014430:Twins, Monozygotic; D014463:Ultrasonography
chemical_list: D001262:Atenolol