Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.
Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells.
Peng
J-B
JB
Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017, USA.
Bell
P D
PD
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D017136:Ion Transport / Q000502:physiology*; D007686:Kidney Tubules, Distal / Q000737:chemistry / Q000502:physiology*; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology; D009154:Mutation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology*; D011546:Pseudohypoaldosteronism / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology; D049992:Sodium Chloride Symporters / Q000032:analysis / Q000187:drug effects / Q000502:physiology
D002352:Carrier Proteins; D049992:Sodium Chloride Symporters; D017346:Protein Serine-Threonine Kinases; C433806:WNK4 protein, human