[New prognostic and predictive factors in advanced colorectal cancer].
Cancer patients often show a clinical tendency to thromboembolic events. This tendency is due to tumor cell-related factors together with the damage of the vascular endothelial exerted by chemotherapy treatment. Gastrointestinal tumors especially contribute to these types of events. More recently, the implication of tumor angiogenesis in clotting/fibrynolisys and plasminogen systems activation has been addressed in cancer patients. Finally, some hemostasis and angiogenesis-related factors such as platelets, von Willebrand factor, fibrinogen, plasminogen activator inhibitor type-1, D dimer, and vascular endotelial growth factor have been highlighted as new potential response and survival predictors in colorectal cancer patients. In this review article, the current evidence supporting the use of these proteins in assessing prognosis in colorectal cancer patients is critically exposed and discussed.
Gil-Bazo
Ignacio
I
Departamento de Oncología, Clínica Universitaria, Universidad de Navarra, Pamplona, Navarra, España. gilbazoi@mskcc.org
Páramo
José Antonio
JA
García-Foncillas
Jesús
J
D015415:Biomarkers / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011379:Prognosis; D042442:Vascular Endothelial Growth Factors / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; D042442:Vascular Endothelial Growth Factors; C036309:fibrin fragment D; D014841:von Willebrand Factor; D005340:Fibrinogen