Feasibility of azithromycin prophylaxis during a pertussis outbreak among healthcare workers in a university hospital in Paris.
The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.
Giugliani
Camila
C
Service de Sante Publique, Groupe Hospitalier Cochin-St. Vincent de Paul, Paris, France.
Vidal-Trecan
Gwenaelle
G
Traore
Souleymane
S
Blanchard
Herve
H
Spiridon
Gabriela
G
Rollot
Florence
F
Launay
Odile
O
Gorodestski
Myriam
M
Marande
Jean-Luc
JL
Vinsonneau
Christophe
C
Guillevin
Loic
L
Salmon-Ceron
Dominique
D
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D017963:Azithromycin / Q000008:administration & dosage*; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious; D005240:Feasibility Studies; D005260:Female; D005602:France; D006282:Health Personnel; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011446:Prospective Studies; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*
D000900:Anti-Bacterial Agents; D017963:Azithromycin