title: Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.
abstract: To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC# 7234, Bethesda, Rockville, MD 20892-7234, USA. wangso@mail.nih.gov
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Robert
authors.initials: R
authors.lastname: Welch
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
mesh_terms: D000328:Adult; D000368:Aged; D017398:Alternative Splicing; D016022:Case-Control Studies; D019940:Genes, bcl-1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors