Preparation of poly(lactic acid) composite hollow spheres containing calcium carbonates.
Poly(lactic acid) composite hollow spheres containing calcium carbonate were prepared by oil-in-water emulsion evaporation to develop injectable bone substitutes incorporated with cells. The spheres were approximately 1.2mm in diameter and had a shell with a thickness in the range of 50-150microm. The hollow in the spheres was presumed to be formed by CO(2) gas generated by the decomposition of vaterite used as a starting material. An open channel approximately 800microm in diameter was formed in the spheres by chemical etching utilizing the rapid dissolution of poly(lactic acid) at the thin portion of the shell. Cells could migrate into the hollow spheres through the open channel and attach to the inner surface.
Maeda
Hirotaka
H
Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
Kasuga
Toshihiro
T
D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D002119:Calcium Carbonate / Q000737:chemistry*; D018929:Cell Culture Techniques; D002465:Cell Movement; D004655:Emulsions / Q000737:chemistry; D005347:Fibroblasts / Q000648:ultrastructure; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D008863:Microspheres; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D004655:Emulsions; D009821:Oils; D011091:Polyesters; D011108:Polymers; D014867:Water; D019344:Lactic Acid; C033616:poly(lactide); D002119:Calcium Carbonate