Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration.
Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. (123)I-FP-CIT/(123)I-beta-CIT SPECT and (123)I-IBZM SPECT as well as (18)F-FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. (18)F-FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD.
Klaffke
Stefanie
S
Department of Neurology, University Medicine Berlin, Berlin, Germany.
Kuhn
Andrea A
AA
Plotkin
Michail
M
Amthauer
Holger
H
Harnack
Daniel
D
Felix
Roland
R
Kupsch
Andreas
A
D000368:Aged; D001549:Benzamides; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D003042:Cocaine / Q000031:analogs & derivatives; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
D001549:Benzamides; D001786:Blood Glucose; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D014326:Tropanes; D019788:Fluorodeoxyglucose F18; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide; D003042:Cocaine