Terpenoids and bisbibenzyls from Chinese liverworts Conocephalum conicum and Dumortiera hirsuta.
Four new monoterpene esters, 2alpha,5beta-dihydroxybornane-2-cinnamate (1), 2alpha,5beta-dihydroxybornane-5-acetyl-2-cinnamate (2), 2alpha,5beta-dihydroxybornane-2-p-hydroxycinnamate (3) and 2alpha,5beta-dihydroxy-bornane-2-cis-p-hydroxycinnamate (4), together with a known compound 3,4-dimethoxystyrene (5) were isolated from Chinese liverwort Conocephalum conicum and six known compounds, 5,7-dihydroxycalamenene (6), 7-hydroxycalamenene (7), lunularin (8), riccardin C (9), marchantin C (10) and riccardin D (11) were isolated from Dumortiera hirsuta. Their structures were elucidated by extensive spectral analysis and chemical correlations. Compounds 1 and 8 showed moderate cytotoxicity against human HepG2 cells with IC50 4.5 microg/ml and 7.4 microg/ml, respectively, while compound 8 also showed antimicrobacterial activity against Pseudomonas aeruginosa with minimum inhibitory concentration at 64 microg/ml.
Lu
Zhi-Qiang
ZQ
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Fan
Pei-Hong
PH
Ji
Mei
M
Lou
Hong-Xiang
HX
D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification*; D002681:China; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification*
D001632:Bibenzyls; D013729:Terpenes