title: [Comparative evaluation of clinical symptoms and status of bone metabolism in patients with heroin and buprenorphine addiction in the period of withdrawal].
abstract: The purpose of this study was the evaluation of clinical heroin symptoms and buprenorphine drug addiction in the withdrawal period with the purpose of their comparison, study of parameters of bone metabolism in the both groups. In the study group were included 40 patients with heroin and 27 with buprenorphine addiction in the period of abstinence. Our investigations have shown, that in the both groups, among clinical symptoms ossalgias, arthralgias and mialgias attributes to the expressed dysfunction of vegetative system, were most prominent. Decrease of sexual functions was found in half of inspected patients. Biochemical investigations have shown intensive clearance of calcium with the urine that indicates intensifying resorbtion processes in the bone tissue. Symptoms of hypogonadism were accompanied by the decrease of the level of testosterone in the blood. Parameters of mineral consistency of the bone tissue was decreased both in patients with heroin and buprenorphine addiction.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Sikharulidze
authors.forename: M G
authors.initials: MG
authors.lastname: Kopaliani
authors.forename: L O
authors.initials: LO
authors.lastname: Kilasoniia
mesh_terms: D001526:Behavioral Symptoms; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D002047:Buprenorphine / Q000506:poisoning*; D005260:Female; D003932:Heroin / Q000506:poisoning; D006556:Heroin Dependence / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009021:Morphine Dependence / Q000175:diagnosis* / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology; D011859:Radiography; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D002047:Buprenorphine; D003932:Heroin