[Anti-inflammatory and reparative effect of olipiphate].
The therapeutic effect of olipiphate was demonstrated for chronic inflammation of advanced arthritis and concanavalin A-related acute edema. The best systemic effect was obtained with 50 mg/kg, symptomatic--100 mg/kg. Skin wounds treated with 5% olipiphate (26 + 2) healed faster than those treated with 2% solcoseryl (30 + 0.8) or in control (33 + 0.6). It was shown histologically that the proliferative and antiphlogistic effect of olipiphate involved no scars.
Nezhinskaia
G I
GI
Gavrovskaia
L K
LK
Berkovich
A M
AM
Filov
V A
VA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology; D003208:Concanavalin A / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005620:Freund's Adjuvant; D008031:Lignin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; C413426:olipifat; D003208:Concanavalin A; D008031:Lignin; D005620:Freund's Adjuvant