[Neurotensin: reception and intracellular mechanisms of signaling].
The review coveres the features of neurotensin receptor, functional role ot its structural elements, nature of conjugation with effectoral cell systems, and mechanisms of receptor decensitization developing as results of prolonged effect of agonist. The author provides pharmacological description of neurotensin antagonists and special features of three subtypes of its receptors. The author reviews the research results establishing a correlation between structural modification of various section of neurotensin molecula and manifestations of its physiological activity. Special focus is mage on discussion of neurotensin's physiological effects developing as results of its modulating impact on discharge of other biologically active substances.
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D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology; D009496:Neurotensin / Q000378:metabolism / Q000502:physiology*; D009928:Organ Specificity; D018028:Receptors, Neurotensin / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000099183:Sortilin
D033942:Adaptor Proteins, Vesicular Transport; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D009496:Neurotensin; D018028:Receptors, Neurotensin; D000099183:Sortilin