An unusual case of Candida tropicalis and Candida krusei arthritis in a patient with acute myelogenous leukemia before chemotherapy.
A 79-year-old male with acute myelogenous leukemia developed acute right knee arthritis during admission, after the use of broad-spectrum antibiotics before chemotherapy. The initial synovial fluid sample appeared to be mildly inflammatory with a low white cell count. The fungal septic arthritis was not diagnosed until Candida tropicalis, a rare species of Candida, was isolated in the synovial fluid. Although fluconazole is effective in treating the microorganism, the untreated leukemia rendered the infection incurable and led to the growth of fluconazole-resistant Candida krusei. We reported the unusual case of fungal arthritis and reviewed the literature.
Wang
Hon-Pin
HP
Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec2, Shih-Pai Road, Taipei 112, Taiwan, Republic of China.
Yen
Yung-Feng
YF
Chen
Wei-Sheng
WS
Chou
Yuh-Lan
YL
Tsai
Chang-Youh
CY
Chang
Hsiao-Ning
HN
Chou
Chung-Tei
CT
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000382:microbiology / Q000473:pathology*; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology / Q000473:pathology*; D008297:Male; D013582:Synovial Fluid / Q000382:microbiology
D000935:Antifungal Agents; D015725:Fluconazole