Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population.
This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 normotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
Khawaja
Muhammad Rizwanulhaq
MR
Taj
Fawad
F
Ahmad
Usman
U
Saleheen
Danish
D
Jafar
Tazeen
T
Frossard
Philippe M
PM
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010154:Pakistan / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D017678:Sex Distribution
C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III