title: Heterogeneous three-dimensional anatomical and electrophysiological model of human atria.
abstract: Investigating the mechanisms underlying the genesis and conduction of electrical excitation in the atria at physiological and pathological states is of great importance. To provide knowledge concerning the mechanisms of excitation, we constructed a biophysical detailed and anatomically accurate computer model of human atria that incorporates both structural and electrophysiological heterogeneities. The three-dimensional geometry was extracted from the visible female dataset. The sinoatrial node (SAN) and atrium, including crista terminalis (CT), pectinate muscles (PM), appendages (APG) and Bachmann's bundle (BB) were segmented in this work. Fibre orientation in CT, PM and BB was set to local longitudinal direction. Descriptions for all used cell types were based on modifications of the Courtemanche et al. model of a human atrial cell. Maximum conductances of Ito, IKr and ICa,L were modified for PM, CT, APG and atrioventricular ring to reproduce measured action potentials (AP). Pacemaker activity in the human SAN was reproduced by removing IK1, but including If, ICa,T, and gradients of channel conductances as described in previous studies for heterogeneous rabbit SAN. Anisotropic conduction was computed with a monodomain model using the finite element method. The transversal to longitudinal ratio of conductivity for PM, CT and BB was 1:9. Atrial working myocardium (AWM) was set to be isotropic. Simulation of atrial electrophysiology showed initiation of APs in the SAN centre. The excitation spread afterwards to the periphery near to the region of the CT and preferentially towards the atrioventricular region. The excitation extends over the right atrium along PM. Both CT and PM activated the right AWM. Earliest activation of the left atrium was through BB and excitation spread over to the APG. The conduction velocities were 0.6ms-1 for AWM, 1.2ms-1 for CT, 1.6ms-1 for PM and 1.1ms-1 for BB at a rate of 63bpm. The simulations revealed that bundles form dominant pathways for atrial conduction. The preferential conduction towards CT and along PM is comparable with clinical mapping. Repolarization is more homogeneous than excitation due to the heterogeneous distribution of electrophysiological properties and hence the action potential duration.
authors.affiliation: Institute of Biomedical Engineering, University Karlsruhe (TH), Kaiserstrasse 12, 76128 Karlsruhe, Germany. gunnar.seemann@ibt.uni-karlsruhe.de
authors.forename: Gunnar
authors.initials: G
authors.lastname: Seemann
authors.forename: Christine
authors.initials: C
authors.lastname: Höper
authors.forename: Frank B
authors.initials: FB
authors.lastname: Sachse
authors.forename: Olaf
authors.initials: O
authors.lastname: Dössel
authors.forename: Arun V
authors.initials: AV
authors.lastname: Holden
authors.forename: Henggui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000200:Action Potentials; D000328:Adult; D016275:Atrial Function / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology; D003198:Computer Simulation; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D053443:Visible Human Projects