[Osteoporosis during rheumatoid arthritis and the peculiarities of its treatment].
The goal of the work was to study the markers of bone metabolism and the indicators of mineral density of bone tissue (MDBT) in the patients with rheumatoid arthritis (RA). 40 patients with rheumatoid arthritis have been investigated who had not received the glucocorticosteroids. For investigation a complex of biochemical markers of bone metabolism have been applied. The obtained results have revealed the increase of excretion of calcium with urine which testifies the increased resorbtion of bone tissue in comparison to norm. The results of dual energy X-ray absorbtiometry (DEXA) have proved the frequency of osteopenia and osteoporosis during the RA; At the same time the inhomogenity of these indices in various fragments of the skeleton was shown. It has been established that lower indices of MDBT were revealed in patients with RA in proximal parts of hip bone and in distal part of forearm. Degree of osteopenia and osteoporosis in these fragments are in correlation with the indices of activity of inflammatory process which gives a possibility to recommend them as the indicators of generalization of osteoporosis. Revealing of osteopenia and osteoporosis in a distal part of the forearm at the earlier stages of the disease does not exclude a possibility of applying the indicators of MDBT as the early diagnostic markers.
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D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications*; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography
D018501:Antirheumatic Agents; D015415:Biomarkers