Transcriptional pausing caught in the act.
Single-molecule techniques now permit the tracking of a transcription complex along a DNA template in real time and to 1 bp resolution. As reported in this issue of Cell, Herbert et al. (2006) exploit this approach to study a central component of transcription regulation, the sequence-dependent pausing of RNA polymerase during transcript elongation.
von Hippel
Peter H
PH
Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA.
D001483:Base Sequence; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000502:physiology*; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA; D013698:Templates, Genetic; D014158:Transcription, Genetic
D012321:DNA-Directed RNA Polymerases