Methods for screening drugs for their pro-arrhythmic liability: does the rabbit ventricular wedge hold the key?
Hancox
Jules C
JC
Department of Physiology, Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK. jules.hancox@bristol.ac.uk
Curtis
Michael J
MJ
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D066298:In Vitro Techniques; D011817:Rabbits; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels