title: Evolving patterns of lymphopoiesis from embryogenesis through senescence.
abstract: Lymphopoiesis occurs throughout adult life, but the number of lymphocytes produced is substantially reduced in old individuals. This commentary will highlight observations suggesting that common mechanisms underlie declines in both B and T cell production and that reductions in lymphopoiesis are initiated much earlier than has generally been appreciated.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095.
authors.forename: Encarnacion
authors.initials: E
authors.lastname: Montecino-Rodriguez
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095. Electronic address: kdorshki@mednet.ucla.edu.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dorshkind
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D047108:Embryonic Development / Q000276:immunology; D038041:Lymphopoiesis; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology