title: End points in clinical trials: are they moving the goalposts?
abstract: In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?
authors.forename: D Y
authors.initials: DY
authors.lastname: Leung
authors.forename: J K
authors.initials: JK
authors.lastname: French
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002986:Clinical Trials as Topic / Q000592:standards*; D001026:Coronary Artery Bypass / Q000379:methods; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D017751:Safety Management; D016896:Treatment Outcome