[Effectiveness of radioprotective action of plaferon LB].
The aim of the study was the investigation of effectiveness of radioprotective action of plaferon LB on rat's ovary during gamma-irradiation. It was established that during irradiation in the rats ovary the mechanisms of follicle genesis ovulation and luteinization are disordered. It was revealed hyperplasia of hormone produced structures by way of thekomatosis. During postradiation action of plaferon LB in ovary with disordered follicle genesis in single follicle the oocyte structure is preserved in dystrophic conditions. It may be concluded, that plaferon LB contributes to the inhibition of hormone produced structures hyperplasia. Preventive action of plaferon LB during 5 days before irradiation provides maintenance of normal structure of oocytes in follicle and increased hyperplasia of stroma. There wasn't revealed the trend towards thekamatosis.
Kasrashvili
M V
MV
Paĭlodze
M V
MV
Datunashvili
I V
IV
D000818:Animals; D005260:Female; D005720:Gamma Rays; D006965:Hyperplasia / Q000517:prevention & control; D009479:Neuropeptides / Q000008:administration & dosage*; D010053:Ovary / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D011837:Radiation-Protective Agents; C091912:plaferon