title: Isolation, structure determination and biological activity of a new glutarimide antibiotic, S632A3.
abstract: A new antibiotic, S632A3, was isolated from a cultured broth of Streptomyces hygroscopicus S632. It was purified by column chromatography on silica gel, Sephadex LH-20 and HPLC. Structural studies by analysis of 1H NMR and 13C NMR, MS, UV and IR spectra in comparison with those of S632A2 clarified that S632A3 is an isomer of 9-methylstreptimidone. In addition, this antibiotic showed potent biological activity including differentiation induction effects on HL-60 cell and antitumour activity in vivo.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Cheng
authors.forename: Qiong-Yan
authors.initials: QY
authors.lastname: Liu
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Chen
authors.forename: Wen-Zao
authors.initials: WZ
authors.lastname: Jin
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Si
authors.forename: Dian-Dong
authors.initials: DD
authors.lastname: Li
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010881:Piperidones; C511904:S632A3