Phytoestrogens from Aspalathus linearis.
From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.
Shimamura
Naomi
N
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Miyase
Toshio
T
Umehara
Kaoru
K
Warashina
Tsutomu
T
Fujii
Satoshi
S
D036903:Aspalathus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D048789:Phytoestrogens / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship
D048789:Phytoestrogens; D004958:Estradiol