Neuroprotective effects of afobazol in experimental cerebral hemorrhage.
The study of novel selective anxiolytic afobazol on rats with experimental intracerebral post-traumatic hematoma (cerebral hemorrhage) demonstrated its efficiency in a dose of 5 mg/kg applied by a single or repeated administration for 2 weeks. The preparation significantly decreased the incidence of neurological disturbances in most rats (pareses, paralyses, convulsive movements, lateral posture). The therapeutic course of afobazol improved survival rate. Afobazol improved learning and memory in rats with cerebral hemorrhage in the conditioned passive avoidance test and positively affected motor activity in the open field test, which was documented by significant increase in total motor activity indices. The effects of afobazol were more pronounced after course treatment.
Galaeva
I P
IP
V. V. Zakusov State Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. i_galaeva@mail.ru
Garibova
T L
TL
Voronina
T A
TA
Seredenin
S B
SB
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D004195:Disease Models, Animal; D006406:Hematoma / Q000188:drug therapy; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009025:Morpholines / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents