title: [Combinatorial synthesis: an important methodology in medicinal chemistry].
abstract: From the stand point of the synthetic chemist, Combinatorial Synthesis involves the use of processes (solid phase synthesis) and strategies (hundreds or thousands of simultaneous reactions) which allow the preparation, in a short time, of big, organized collections of organic compounds, the so called molecular libraries. Without isolation or purification of individual compounds, deconvolution allows the evaluation of mixtures for biological activity. These libraries, if smartly designed, are becoming an essential source in the discovery and development of new molecules for pharmacology. The structurally diverse compounds are submitted to high throughput screening in a rapid search for lead compounds. On the other hand, the so called parallel combinatorial synthesis offers an efficient route for the structural optimisation obtaining, individually but simultaneously, a wide variety of derivatives of the lead compound.
authors.forename: Carlos
authors.initials: C
authors.lastname: Seoane Prado
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*