title: Activity related to the carcinogenicity of plastic additives in the benzophenone group.
abstract: This study examines the activities relating to the carcinogenicity of six types of benzophenone derivatives (benzophenone, 2-hydroxy-4-octyloxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone) currently used in plastic products as additives to serve as ultraviolet absorbing agents. The evaluation of the initiation activity used a light absorption umu-test, a luminescent umu-test and the Ames test. The promotion activity was examined by a Bhas assay, a method that uses Bhas 42 cells for the formation of transformation foci. The luminescent umu-test indicated positive initiation activity of 2-hydroxy-4-methoxybenzophenone, and pseudo-positive activity of 2,4-dihydroxybenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone. In the Ames test, 2-hydroxy-4-octyloxybenzophenone showed pseudo-positive initiation activity. Conversely, 2,4-dihydroxybenzophenone indicated weak promotion activity at 10 microg/ml concentration.
authors.affiliation: Research Centerfor Environmental Risk, National Institutefor Environmental Studies, Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakajima
authors.forename: Shin
authors.initials: S
authors.lastname: Asada
authors.forename: Shiho
authors.initials: S
authors.lastname: Kageyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kuramochi
authors.forename: Noriho
authors.initials: N
authors.lastname: Tanaka
authors.forename: Ken
authors.initials: K
authors.lastname: Takeda
authors.forename: Sumio
authors.initials: S
authors.lastname: Goto
mesh_terms: D001577:Benzophenones / Q000494:pharmacology / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002273:Carcinogens; D010968:Plasticizers; D010969:Plastics / Q000737:chemistry*
chemical_list: C513227:2-hydroxy-4-octyloxybenzophenone; D001577:Benzophenones; D002273:Carcinogens; D010968:Plasticizers; D010969:Plastics; C047723:benzophenone; C005290:oxybenzone; C121479:2,4-dihydroxybenzophenone