title: Diagnostic value of procalcitonin measurement in febrile patients with systemic autoimmune diseases.
abstract: OBJECTIVE
  To determine the usefulness of plasma procalcitonin (PCT) measurement to suspect infectious etiology in febrile patients with systemic autoimmune disease.
  
  
  METHODS
  PCT, C-Reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count (WBC) were measured in 44 consecutive inpatients with a diagnosis of systemic autoimmune disease and fever >38 masculine C. After careful microbiologic screening no obvious infection was demonstrated in 24 patients (Group A) while an infectious bacterial complication was diagnosed in 20 cases (Group B).
  
  
  RESULTS
  Median PCT levels were significantly higher in the group B (1.11 vs 0.24 ng/ml; p = 0.0007), whereas the differences for CRP, WBC and ESR did not reach statistical significance. PCT also exhibited a good sensitivity and specificity (75%) in differentiating patients with infection from those with disease flare. With respect to positive and negative predictive values (71.4% and 78.2%), PCT markedly exceeded the other variables. By analyzing PCT values by disease we identified a false positive subgroup of patients suffering from adult onset Still's disease (AOSD), showing markedly elevated PCT levels in absence of infection. By excluding these patients, PCT showed a very good sensitivity and specificity (73.6% and 89.4%) and the area under receiver operating characteristics (ROC) curve rose from 0.801 to 0.904.
  
  
  CONCLUSIONS
  Our data indicate that elevated PCT concentrations offer good sensitivity and specificity for the diagnosis of systemic bacterial infection in febrile patients with systemic autoimmune diseases. However, in fever associated with AOSD PCT may be elevated even in the absence of infectious complication.
authors.affiliation: Rheumatology and Rheumatology Unit, University of Pavia, IRCCS Policlinico S. Matteo and Immunohematology Unit, IRCCS Policlinico S. Matteo, Pavia, Italy.
authors.forename: C A
authors.initials: CA
authors.lastname: Scirè
authors.forename: L
authors.initials: L
authors.lastname: Cavagna
authors.forename: C
authors.initials: C
authors.lastname: Perotti
authors.forename: E
authors.initials: E
authors.lastname: Bruschi
authors.forename: R
authors.initials: R
authors.lastname: Caporali
authors.forename: C
authors.initials: C
authors.lastname: Montecucco
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005189:False Positive Reactions; D005334:Fever / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000175:diagnosis
chemical_list: C000606589:CALCA protein, human; D006023:Glycoproteins; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide