Form I of desloratadine, a tricyclic antihistamine.
The title compound [systematic name: 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[4,5]cyclohepta[2,1-b]pyridine], C19H19ClN2, was crystallized from ethyl acetate. The interesting feature of the reported structure is that it does not contain any strong hydrogen bonds, although the molecule contains a secondary NH group, which is a good hydrogen-bond donor.
Bhatt
Prashant M
PM
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Desiraju
Gautam R
GR
D018360:Crystallography, X-Ray; D006634:Histamine H1 Antagonists / Q000737:chemistry*; D006860:Hydrogen Bonding; D017336:Loratadine / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D006634:Histamine H1 Antagonists; D017336:Loratadine; C121345:desloratadine