title: Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
abstract: A previous autopsy study of patients with amnestic-type mild cognitive impairment (MCI) suggested an overrepresentation of argyrophilic grain disease (AGD). We studied 34 patients who had diagnoses of amnestic MCI during progression to dementia and who came to autopsy. Neuropathologic evaluation included routine histochemical and immunohistochemical methods, including a 4-repeat tau-specific marker (ET3). AGD was found in association with a variety of neuropathologic diseases in 18 (53%) cases but was the primary pathologic finding in only one (3%) case. ET3 allowed the detection of AGD in 5 additional cases missed using standard techniques. Cases with AGD were significantly older than those without (mean, 94 vs 84 years; p < 0.004, rank sum test). No significant differences were found between groups for other demographic variables, association of AGD with neuropathologic findings of Alzheimer disease, Lewy body, or cerebrovascular disease, or global measures of cognitive function, although there was a nonsignificant trend towards worsening cognitive status in cases with AGD. AGD is a common pathologic finding in subjects who have been diagnosed with amnestic MCI.
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. gajich2@email.uky.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Jicha
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Smith
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: Kris A
authors.initials: KA
authors.lastname: Johnson
authors.forename: Ruth
authors.initials: R
authors.lastname: Cha
authors.forename: Michael W
authors.initials: MW
authors.lastname: Delucia
authors.forename: Heiko
authors.initials: H
authors.lastname: Braak
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D000647:Amnesia / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003072:Cognition Disorders / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D011180:Postmortem Changes; D012189:Retrospective Studies; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins