title: Surgical treatment of a neonate with refractory seizures secondary to congenital giant cell astrocytoma: case report and literature review.
abstract: Congenital brain tumours are rare. They account for 0.5% to 1.9% of intracranial tumours in childhood and have an incidence of 0.34 per million live births. Most congenital brain tumours are neuro-ectodermal tumours and medulloblastomas; giant cell astrocytoma and other tuberous sclerosis-related tumours are rare. We report on a neonate who developed seizures that were refractory to medical treatment. Imaging studies revealed a right frontal calcified tumour. Surgical resection was performed successfully and pathology revealed the tumour to be a giant cell astrocytoma. The child was seizure-free afterwards.
authors.affiliation: Division of Neurosurgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: S F
authors.initials: SF
authors.lastname: Hon
authors.forename: G K C
authors.initials: GK
authors.lastname: Wong
authors.forename: X L
authors.initials: XL
authors.lastname: Zhu
authors.forename: H K
authors.initials: HK
authors.lastname: Ng
authors.forename: N C
authors.initials: NC
authors.lastname: Sin
authors.forename: W S
authors.initials: WS
authors.lastname: Poon
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001254:Astrocytoma / Q000150:complications / Q000151:congenital* / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000151:congenital* / Q000601:surgery; D003399:Craniotomy; D004351:Drug Resistance; D004569:Electroencephalography; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications / Q000151:congenital* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D000927:Anticonvulsants