title: Observer-independent analysis of high-resolution MR images of the human cerebral cortex: in vivo delineation of cortical areas.
abstract: Using high-resolution MRI, it is now possible to examine the living human cortex down to a resolution of less than 300 mum. Thus, in vivo imaging is now approaching the resolution that has been successfully used in histological analysis of the cerebral cortex for many years, e.g., low-magnification light microscopy. This allows unprecedented views of cortical microstructure that reflect defined histological features, specifically, individual cortical layers. As in histological brain mapping, it is possible to use the changes in the cortical lamination patterns to define individual cortical areas. This allows in vivo neuroanatomical maps to be generated for individual subjects and precise correlation of the results from functional imaging studies in these subjects with their own microanatomical information. To this end, we adapted the well-established observer-independent cytoarchitectonic mapping techniques for defining cortical borders based on changes in cortical lamination for in vivo parcellation of high-resolution structural MR images.
authors.affiliation: Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Australia.
authors.forename: Nathan B
authors.initials: NB
authors.lastname: Walters
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.forename: Axel
authors.initials: A
authors.lastname: Schleicher
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.forename: Gary F
authors.initials: GF
authors.lastname: Egan
authors.forename: John D G
authors.initials: JD
authors.lastname: Watson
mesh_terms: D001931:Brain Mapping / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009039:Motion Perception / Q000502:physiology; D009445:Neuroanatomy / Q000295:instrumentation / Q000379:methods; D009778:Occipital Lobe / Q000166:cytology* / Q000502:physiology*; D010775:Photic Stimulation