Treatment of comorbidities besides the treatment of primary tumor may further increase effective management of cancer.
For most of the patients with cancer comorbidity had independent prognostic effect. This negative influence of comorbidity on survival of cancer might be due to several mechanisms: the increased risk of death due to the comorbid condition itself, more contra-indications for anti-cancer treatment, more indications for dose reduction and a higher rate of treatment-related complications, such as infections and cardiovascular events. It is known that in some chronic diseases (e.g., coronary artery disease, hypertension, and obesity) pro-angiogenic growth factors are increased compared to controls and mostly normalized after specific treatment. We propose that increased pro-angiogenic growth factor levels in cancer patients due to comorbidities may lead to the progression of the tumors and poor prognosis. Treatment of comorbidities besides the treatment of primary tumor may further increase effective management of cancer.
Aksoy
Sercan
S
Department of Medical Oncology, Hacettepe University, Institute of Oncology, 06100 Sihhiye, Ankara, Turkey. saksoy07@yahoo.com
Aksoy
Hatice
H
Harputluoglu
Hakan
H
Kilickap
Saadettin
S
Altundag
Kadri
K
D043925:Angiogenesis Inducing Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015897:Comorbidity; D019468:Disease Management; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate
D043925:Angiogenesis Inducing Agents; D000970:Antineoplastic Agents