Lamotrigine serum concentrations throughout the menstrual cycle--a study of 2 cases.
OBJECTIVE
To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle.


METHODS
Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception.


CONCLUSIONS
The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically relevant changes in lamotrigine serum concentrations.
Reimers
Arne
A
Department of Clinical Pharmacology, St Olavs University Hospital, Trondheim, Norway. arne.reimers@legemidler.no
Brodtkorb
Eylert
E
Helde
Grethe
G
Spigset
Olav
O
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008597:Menstrual Cycle / Q000097:blood* / Q000187:drug effects; D014227:Triazines / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use
D014227:Triazines; D000077213:Lamotrigine