title: [Gout and diabetes].
abstract: Gout is the most frequent cause of acute arthritis in men over 40 years of age. In the recent years, gout incidence has been increasing in developed countries probably due to dietary changes, alcohol consumption, ageing of population and also application of high-risk medications. Hyperuricemia is one of the symptoms of hyperinsulinism and metabolic syndrome. The level of uricemia correlates with the degree of insulin resistance. Correlation of uric acid levels and the risk of coronary and cerebral accidents were reported both in diabetic and non-diabetic population. It has not been explained satisfactorily whether this is the direct result of hyperuricemia or concurrently present symptom of metabolic syndrome. The study describes symptomatology of clinical signs of gout and discusses about appropriate therapeutic approach in each stage of the disease. New therapeutic possibilities that are still in the stage of clinical studies are mentioned. Also, we focus on alternative dietary recommendations for hyperuricemia and gout patients. The reason of changes in dietary regime is the effort to alleviate the signs of metabolic syndrome. The study emphasises the practical significance of screening of metabolic syndrome signs during examination of gout patients so that appropriate targeted therapeutic intervention could be performed. On the contrary, increased risk of gout-induced movement disorders should be taken into account in patients with diagnosed insulin resistance.
authors.affiliation: II. interni klinika Lékarské fakulty UK a FN, Hradec Králové. bradna@fnhk.cz
authors.forename: P
authors.initials: P
authors.lastname: Bradna
mesh_terms: D015210:Arthritis, Gouty / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D048909:Diabetes Complications; D006073:Gout / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans