title: Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination.
abstract: OBJECTIVE
  To evaluate the association between obesity and the outcome of superovulation and intrauterine insemination (IUI) in infertile ovulatory women.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University-based infertility clinic.
  
  
  METHODS
  Three hundred thirty-three ovulatory women, grouped by body mass index (BMI) categories, who received superovulation and IUI for treatment of infertility.
  
  
  METHODS
  None.
  
  
  METHODS
  
  
  
  METHODS
  cycle fecundity.
  
  
  RESULTS
  total dose of gonadotropins, serum level of E(2), and number of follicles >or=17 mm on the day of hCG injection.
  
  
  RESULTS
  Adjusted cycle fecundity was not different among BMI groups (underweight: 0.14 [95% CI: {0.07, 0.29}], normal weight: 0.12 [95% CI: {0.09, 0.16}], overweight: 0.17 [95% CI: {0.12, 0.24}], and obese: 0.14 [95% CI: {0.08, 0.23}]). Adjusted total gonadotropin dose (IU/cycle) was greater in obese women than in underweight or normal-weight women. Although the numbers of large follicles were not different, E(2) levels (pg/mL) were lower in obese women than in normal-weight and overweight women.
  
  
  CONCLUSIONS
  Our sample of ovulatory infertile women demonstrated that treatment-related cycle fecundity is unaffected by obesity. We conclude that obese, infertile ovulatory women require a greater dose of gonadotropins to achieve similar levels of superovulation than normal, underweight or overweight women.
authors.affiliation: Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania, USA. wdodson@psu.edu
authors.forename: William C
authors.initials: WC
authors.lastname: Dodson
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D007315:Insemination, Artificial / Q000706:statistics & numerical data*; D009765:Obesity / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D010414:Pennsylvania / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013223:Statistics as Topic; D016896:Treatment Outcome