title: AID for innate immunity to retroviral transformation.
abstract: AID is a cytidine deaminase essential for class switch recombination and somatic hypermutation during the humoral immune response. In this issue of Immunity, Gourzi et al. (2006) show that AID also plays a critical role in innate immunity to virally induced acute pro-B cell leukemia.
authors.affiliation: Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720. Electronic address: mss@berkeley.edu.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Schlissel
authors.affiliation: Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720.
authors.forename: Tracy C
authors.initials: TC
authors.lastname: Kuo
mesh_terms: D000011:Abelson murine leukemia virus / Q000276:immunology*; D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000502:physiology*; D007942:Leukemia, Experimental / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D012192:Retroviridae Infections / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D014412:Tumor Virus Infections / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase