Effect of antidepressant drugs on 6-OHDA-treated mice in the FST.
There is growing evidence suggesting that dopamine could be indirectly involved in the appearance of behavioural effects of antidepressants. In this study, we induced a partial (over 70%) and non-reversible depletion of dopamine-containing neurons in mice by i.c.v. infusion of 6-OHDA. Then, we compared the antidepressant-like effect of drugs (citalopram, paroxetine, desipramine and imipramine) with or without dopamine depletion in the mice forced swimming test. Our results clearly show that lesion with 6-OHDA does not modify the response of mice to desipramine and imipramine, whereas dopamine depletion abolished the antidepressant-like effect of citalopram and paroxetine. It could then be suggested that antidepressant-like effect of selective serotonin reuptake inhibitors (paroxetine and citalopram) in the mice FST requires the activation of dopaminergic pathways to occur.
Chenu
F
F
Neurobiologie de l'Anxiété et de la Dépression, EA 3256, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France.
Dailly
E
E
Bourin
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D015306:Biogenic Monoamines / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D015283:Citalopram / Q000494:pharmacology; D003863:Depression / Q000523:psychology*; D003891:Desipramine / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D017072:Neostriatum / Q000378:metabolism; D016627:Oxidopamine / Q000008:administration & dosage / Q000494:pharmacology*; D017374:Paroxetine / Q000494:pharmacology; D013550:Swimming / Q000523:psychology*
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D015306:Biogenic Monoamines; D018765:Dopamine Uptake Inhibitors; D015283:Citalopram; D017374:Paroxetine; D016627:Oxidopamine; D007099:Imipramine; D003891:Desipramine