[Dynamic effects of gallium chloride on osteoporotic rat model induced by tretinoin].
OBJECTIVE
To investigate the effect of gallium salts on bone metabolism in osteoporosis rats caused by tretinoin.


METHODS
After duplicating osteoporotic model of rats by using tretinoin, we observed the metabolism of blood, urine and bone in vivo. The rats were divided into control group, osteoporosis group, estrogen treated and gallium chloride treated group. The indexes of bone metabolism and related indexes in serum and urine were observed after 60 days of treatment. In the same time, we observed the dynamic effect of 30 days and 60 days of treatment.


RESULTS
After duplicating osteoporotic model, rats' bone structures were injured, the bone mineral density and the organic matrix decreased, the contents of tartrate-resistant acid phosphatase (TRAP) in serum were higher. After gallium salt treating, the above damages were inhibited or retarded. Trabecular width and thickness of bone cortex were significantly increased. AKP and TRAP activities were decreased to the level close to that of the control group.


CONCLUSIONS
Gallium salt is effective in treating osteoporosis.
Dai
Xiao-xia
XX
Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Xiong
Yong-min
YM
Guo
Xiong
X
Xue
Li
L
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density; D004195:Disease Models, Animal; D005260:Female; D005708:Gallium / Q000627:therapeutic use*; D007527:Isoenzymes / Q000097:blood; D010024:Osteoporosis / Q000139:chemically induced* / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase; D014212:Tretinoin
D007527:Isoenzymes; C034163:gallium chloride; D014212:Tretinoin; D005708:Gallium; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase