title: Histopathological changes in cases of aluminium phosphide poisoning.
abstract: Of a total of 205 poisoning deaths in our hospital in 2003, 83 cases were due to Aluminium phosphide poisoning and were further analyzed. Most vulnerable age group was 21-40 years and M:F ratio was 2:1. On naked eye examination, almost all the vital organs were found to be congested. On microscopic study, the liver showed central venous congestion, degeneration, haemorrhage, sinusoidal dilation, bile stasis, centrilobular necrosis, Kupffer cell hyperplasia, infiltration by mononuclear cells and fatty change. Microscopy of the lungs revealed alveolar thickening, oedema, dilated capillaries, collapsed alveoli and haemorrhage. In the kidney, changes were degeneration, infiltration, tubular dilation and cloudy swelling. Changes in the brain included congestion and coagulative necrosis and in the stomach, congestion and haemorrhage. Easy availability of this cheap and highly toxic substance was responsible for the sudden spurt of poisoning with aluminium phosphide.
authors.affiliation: The Department of Forensic Medicine, Moti Lal Nehru Medical College, Allahabad.
authors.forename: U S
authors.initials: US
authors.lastname: Sinha
authors.forename: A K
authors.initials: AK
authors.lastname: Kapoor
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: Ravi
authors.initials: R
authors.lastname: Mehrotra
mesh_terms: D000293:Adolescent; D000328:Adult; D017607:Aluminum Compounds / Q000506:poisoning*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000506:poisoning*; D010720:Phosphines / Q000506:poisoning*; D013270:Stomach / Q000187:drug effects / Q000473:pathology
chemical_list: D017607:Aluminum Compounds; D010575:Pesticides; D010720:Phosphines; C001864:aluminum phosphide