title: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis.
abstract: OBJECTIVE
  Familialadenomatous polyposis (FAP) is an autosomal-dominant disorder characterized by the development of hundreds of colorectal adenomas and eventual colorectal cancer. Regression of adenomas in this syndrome occurs with the administration of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors, but these compounds can have considerable side effects. We evaluated the efficacy of the combination of diet-derived nonprescription supplements curcumin and quercetin to regress adenomas in patients with FAP.
  
  
  METHODS
  Five FAP patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day. The number and size of polyps were assessed at baseline and after therapy. The Wilcoxon signed-rank test was used to determine differences in the number and size of polyps. Treatment side effects and medication compliance also were evaluated.
  
  
  RESULTS
  All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin. The mean percent decrease in the number and size of polyps from baseline was 60.4% (P < .05) and 50.9% (P < .05), respectively. Minimal adverse side effects and no laboratory abnormalities were noted.
  
  
  CONCLUSIONS
  The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity. Randomized controlled trials are needed to validate these findings.
authors.affiliation: Department of Medicine, Cleveland Clinic, Weston, Florida, USA.
authors.forename: Marcia
authors.initials: M
authors.lastname: Cruz-Correa
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Shoskes
authors.forename: Patricia
authors.initials: P
authors.lastname: Sanchez
authors.forename: Rhongua
authors.initials: R
authors.lastname: Zhao
authors.forename: Linda M
authors.initials: LM
authors.lastname: Hylind
authors.forename: Steven D
authors.initials: SD
authors.lastname: Wexner
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D003474:Curcumin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011794:Quercetin / Q000627:therapeutic use*; D012812:Sigmoidoscopy
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D011794:Quercetin; D003474:Curcumin