Analysis of algorithms predicting blood:air and tissue:blood partition coefficients from solvent partition coefficients for prevalent components of JP-8 jet fuel.
Algorithms predicting tissue and blood partition coefficients (PCs) from solvent properties were compared to assess their usefulness in a petroleum mixture physiologically based pharmacokinetic/pharmacodynamic model. Measured blood:air and tissue:blood PCs for rat and human tissues were sought from literature resources for 14 prevalent jet fuel (JP-8) components. Average experimental PCs were compared with predicted PCs calculated using algorithms from 9 published sources. Algorithms chosen used solvent PCs (octanol:water, saline or water:air, oil:air coefficients) due to the relative accessibility of these parameters. Tissue:blood PCs were calculated from ratios of predicted tissue:air and experimental blood:air values (PCEB). Of the 231 calculated values, 27% performed within +/- 20% of the experimental PC values. Physiologically based equations (based on water and lipid components of a tissue type) did not perform as well as empirical equations (derived from linear regression of experimental PC data) and hybrid equations (physiological parameters and empirical factors combined) for the jet fuel components. The major limitation encountered in this analysis was the lack of experimental data for the selected JP-8 constituents. PCEB values were compared with tissue:blood PCs calculated from ratios of predicted tissue:air and predicted blood:air values (PCPB). Overall, 68% of PCEB values had smaller absolute % errors than PCPB values. If calculated PC values must be used in models, a comparison of experimental and predicted PCs for chemically similar compounds would estimate the expected error level in calculated values.
Sterner
Teresa R
TR
Operational Technologies Corp., Bldg 837, 2729 R Street Wright-Patterson, AFB, Ohio 45433, USA. teri.sterner@wpafb.af.mil
Goodyear
Charles D
CD
Robinson
Peter J
PJ
Mattie
David R
DR
Burton
G Allen
GA
D000273:Adipose Tissue / Q000737:chemistry; D000388:Air / Q000032:analysis*; D000465:Algorithms; D000818:Animals; D001774:Blood Chemical Analysis; D001923:Brain Chemistry; D006801:Humans; D006838:Hydrocarbons / Q000032:analysis* / Q000494:pharmacology; D019570:Inhalation Exposure; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008954:Models, Biological; D051381:Rats; D012995:Solubility
D006838:Hydrocarbons; C098607:JP8 aviation fuel