Maternal serum and amniotic fluid inhibin A levels in women who subsequently develop severe preeclampsia.
The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia.
Kim
Shin-Young
SY
Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ryu
Hyun-Mee
HM
Yang
Jae-Hyug
JH
Kim
Moon-Young
MY
Ahn
Hyun-Kyong
HK
Shin
Joong-Sik
JS
Choi
Jun-Seek
JS
Park
So-Yeon
SY
Kim
Jin-Mi
JM
Lee
Bom-Yi
BY
Kim
Do-Jin
DJ
D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007265:Inhibins / Q000096:biosynthesis* / Q000097:blood*; D008423:Maternal Age; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012307:Risk Factors
C422362:inhibin A; D007265:Inhibins