In vivo larvicidal activity of monoterpenic derivatives from aromatic plants against L3 larvae of Anisakis simplex s.l.
In view of the lack of an effective pharmacological treatment against human anisakiosis, a disease produced by L(3) larvae of the genus Anisakis present in raw fish, we studied the in vivo larvicidal effect of certain monoterpenic derivatives against L(3) of A. simplex s.l. The aldehydic monoterpene citral and the alcoholic citronellol, when they are administered together to the larvae of the nematode at the concentration of 46.90 mg/0.5 ml in olive oil, achieve 85.90% and 67.53% dead L(3), respectively, and also stop rats suffering gastrointestinal hemorrhages produced by the larvae.
Hierro
I
I
Departamento de Parasitología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, 18071 Granada, Spain.
Valero
A
A
Navarro
M C
MC
D000080462:Acyclic Monoterpenes; D000818:Animals; D017129:Anisakiasis / Q000188:drug therapy*; D017163:Anisakis; D005260:Female; D041981:Gastrointestinal Tract / Q000469:parasitology / Q000473:pathology; D007814:Larva; D039821:Monoterpenes / Q000009:adverse effects / Q000627:therapeutic use*; D009195:Peroxidase / Q000378:metabolism; D010938:Plant Oils / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats
D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D010938:Plant Oils; D009195:Peroxidase; C007078:citronellol; C007076:citral