title: The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins.
abstract: The super-sensitivity of the neurohormone melatonin to light in patients with bipolar disorder provides evidence of the circadian nature of the disorder. This response has been proposed as an endophenotype for identifying people at risk of the disorder and guiding investigations of molecular genetic targets. However, before this response is used as an endophenotypic marker, the heritable nature of melatonin sensitivity in the normal population must be established. The aim of this study was to investigate the heritability of nocturnal melatonin secretion and sensitivity to light in monozygotic and dizygotic twins with no psychiatric history. This study investigated overall melatonin levels (between 2000 and 2400 h) and suppression by 500 lx of light (between 2400 and 0100 h) in 20 pairs of twins (nine monozygotic, 11 dizygotic). The results indicate that melatonin secretion is highly heritable with secretion in one twin being a significant predictor of secretion in their twin in both monozygotic and dizygotic pairs. In relation to light sensitivity, genetic loading appears to play a significant role with the greatest concordance between monozygotic twins, followed by dizygotic twins and finally low concordance in unrelated individuals. This provides additional support for the usefulness of melatonin sensitivity to light as a potential endophenotypic marker of bipolar affective disorder.
authors.affiliation: Department of Psychiatry, Austin Health, The University of Melbourne, Heidelberg Vic., Australia. khallam@unimelb.edu.au
authors.forename: Karen T
authors.initials: KT
authors.lastname: Hallam
authors.forename: James S
authors.initials: JS
authors.lastname: Olver
authors.forename: Vanessa
authors.initials: V
authors.lastname: Chambers
authors.forename: Denovan P
authors.initials: DP
authors.lastname: Begg
authors.forename: Caroline
authors.initials: C
authors.lastname: McGrath
authors.forename: Trevor R
authors.initials: TR
authors.lastname: Norman
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects; D003624:Darkness; D015536:Down-Regulation / Q000235:genetics / Q000502:physiology / Q000528:radiation effects*; D005260:Female; D040741:Genetic Load; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000097:blood* / Q000378:metabolism* / Q000528:radiation effects; D010870:Pineal Gland / Q000378:metabolism / Q000528:radiation effects; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric; D014429:Twins, Dizygotic / Q000097:blood* / Q000235:genetics; D014430:Twins, Monozygotic / Q000097:blood* / Q000235:genetics
chemical_list: D008550:Melatonin