title: Relapse of stage I small cell lung cancer ten or more years after the start of treatment.
abstract: Most patients with small cell lung cancer (SCLC) usually show relapse within 1 or 2 years. Relapses after a 5-year disease-free survival are extremely rare. This report describes two patients with stage I SCLC in whom the disease recurred 10 or more years after the start of initial therapy. Because the recurrence of SCLC was noted in the mediastinal lymph nodes of the same side, we concluded that the patients had a late relapse of SCLC rather than a metachronous lung cancer.
authors.affiliation: Department of Thoracic Malignancy, Medical Center for Respiratory and Allergic Diseases of Osaka Prefecture, Osaka 583-8588, Japan. kmatsui@hbk.pref.osaka.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Matsui
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sawa
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Norio
authors.initials: N
authors.lastname: Okamoto
authors.forename: Takuhito
authors.initials: T
authors.lastname: Tada
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nagano
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Masuda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary