[Design, synthesis and insulin-sensitizing activity of indole derivatives].
OBJECTIVE
To design and synthesize compounds with insulin-sensitizing activity.


METHODS
Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.


RESULTS
One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.


CONCLUSIONS
This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
Tang
Lei
L
School of Pharmacy, Guiyang Medical College, China. tlei1974@hotmail.com
Yang
Yu-she
YS
Ji
Ru-yun
RY
D041721:3T3-L1 Cells / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D014280:Triglycerides / Q000378:metabolism
D007004:Hypoglycemic Agents; D007211:Indoles; D007328:Insulin; D014280:Triglycerides