Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress.
Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe recent findings on the regulation of neurogenesis after stroke, in particular regarding the duration of the neurogenic response and the influence of age, as well as the molecular mechanisms influencing migration and survival of the new neurons. We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain.
Kokaia
Zaal
Z
Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE-221 84 Lund, Sweden. Zaal.Kokaia@med.lu.se
Thored
Pär
P
Arvidsson
Andreas
A
Lindvall
Olle
O
D000818:Animals; D002449:Cell Aggregation; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D005246:Feedback; D020547:Lateral Ventricles / Q000473:pathology* / Q000503:physiopathology*; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000473:pathology*; D038081:Organogenesis / Q000502:physiology; D051381:Rats; D012586:Science / Q000639:trends; D013234:Stem Cells / Q000473:pathology*; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology*