title: Pyoderma gangrenosum as initial manifestation of Graves' disease.
abstract: Pyoderma gangrenosum (PG) is an uncommon ulcerative condition. It is most commonly associated with inflammatory bowel disease, haematological malignancies and autoimmune disease. We report on two patients have developed PG during the initial course of Graves' disease (GD), prior to treatment of this condition. The lesions completely cleared with treatment by colchicine in the first case and with oral ciclosporin in the second case. The report emphasizes that a diagnostics of PG should be considered in patients with GD and skin ulcers.
authors.affiliation: Department of Dermatology, Mulhouse General Hospital, and Strasbourg University Hospital, France. cristina_livideanu@yahoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Livideanu
authors.forename: D
authors.initials: D
authors.lastname: Lipsker
authors.forename: C
authors.initials: C
authors.lastname: Paul
authors.forename: J
authors.initials: J
authors.lastname: Juillard
authors.forename: B
authors.initials: B
authors.lastname: Schubert
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001706:Biopsy; D003078:Colchicine / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007871:Leg Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D006074:Gout Suppressants; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003078:Colchicine