title: Isolated biliary granulocytic sarcoma followed by acute myelogeneous leukemia with multilineage dysplasia: a case report and literature review.
abstract: Granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells. Primary involvement of the biliary tract without evidence of leukemia is exceedingly rare. Here, we report an isolated biliary granulocytic sarcoma in a 30-yr-old man who presented with jaundice, fever, and chill without any evidence of leukemia. However, five months after the diagnosis, he developed acute myelogenous leukemia with multilineage dysplasia and chromosomal abnormality. A rare possibility of biliary granulocytic sarcoma should be considered as a differential diagnosis in patients with obstructive jaundice. A histologic evaluation by aggressive diagnostic intervention is important and may improve prognosis.
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Chang Ohk
authors.initials: CO
authors.lastname: Sung
authors.forename: Young Hyeh
authors.initials: YH
authors.lastname: Ko
authors.forename: Cheol Keun
authors.initials: CK
authors.lastname: Park
authors.forename: Kee Taek
authors.initials: KT
authors.lastname: Jang
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Heo
mesh_terms: D000328:Adult; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000473:pathology*; D001652:Bile Ducts / Q000378:metabolism / Q000473:pathology; D019070:Cell Lineage; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D011379:Prognosis; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000473:pathology*; D014057:Tomography, X-Ray Computed