[VCAM-1 and E-selectin expression in extravillous cytotrophoblasts of severe preeclampsia].
OBJECTIVE
To investigate the expression pattern of vascular cell adhesion molecule-1(VCAM-1) and endothelial selectin (E-selectin) in the placental bed extravillous cytotrophoblast (EVCT) as well as its relationship with preeclampsia.


METHODS
Placentas from severe preeclampsia (n=20) and gestional age-matched normal pregnancies (n=20) were studied. The staining intensity and the Mean Optical Density (MOD) of VCAM-1 and E-selectin in EVCT of placental bed deciduas were measured by immunohistochemistry.


RESULTS
The staining intensity and MOD of VCAM-1 and E-selectin on placental bed EVCT in severe preeclampsia were significantly lower than those in the control group respectively (P<0.05, P<0.01).


CONCLUSIONS
The decreased EVCT expression of vascular adhesion phenotype VCAM-1 and E-selectin may account for the shallow trophoblast invasion in preeclampsia, which is the major pathological change of this disease.
Xing
Ai-yun
AY
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Liu
Shu-yun
SY
You
Yong
Y
Yang
Kai-xuan
KX
D000328:Adult; D019040:E-Selectin / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics
D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1