title: The manufacture of synthetic non-sintered and degradable bone grafting substitutes.
abstract: A new synthetic bone grafting substitute (NanoBone, ARTOSS GmbH, Germany) is presented. This is produced by a new technique, the sol-gel-method. This bone grafting substitute consists of nanocrystalline hydroxyapatite (HA) and nanostructured silica (SiO2). By achieving a highly porous structure good osteoconductivity can be seen. In addition, the material will be completely biodegraded and new own bone is formed. It has been demonstrated that NanoBone is biodegraded by osteoclasts in a manner comparable to the natural bone remodelling process.
authors.affiliation: Artoss GmbH, Rostock, Germany. gerike@artoss.com
authors.forename: W
authors.initials: W
authors.lastname: Gerike
authors.forename: V
authors.initials: V
authors.lastname: Bienengräber
authors.forename: K-O
authors.initials: KO
authors.lastname: Henkel
authors.forename: T
authors.initials: T
authors.lastname: Bayerlein
authors.forename: P
authors.initials: P
authors.lastname: Proff
authors.forename: T
authors.initials: T
authors.lastname: Gedrange
authors.forename: Th
authors.initials: T
authors.lastname: Gerber
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D016723:Bone Remodeling; D018786:Bone Substitutes / Q000138:chemical synthesis*; D016025:Bone Transplantation / Q000295:instrumentation* / Q000379:methods; D002516:Ceramics / Q000378:metabolism; D017886:Durapatite / Q000378:metabolism; D006801:Humans; D036103:Nanotechnology; D013552:Swine; D013556:Swine, Miniature
chemical_list: D018786:Bone Substitutes; D017886:Durapatite