title: An alternative approach to amyloid fibrils morphology: CdSe/ZnS quantum dots labelled beta-amyloid peptide fragments Abeta (31-35), Abeta (1-40) and Abeta (1-42).
abstract: Abeta (31-35) peptide and control peptides as well as full length Abeta (1-40) and Abeta (1-42) peptides were labelled with luminescent CdSe/ZnS quantum dots (QDs) to observe the morphology of amyloid fibers. A comparison was made between QDs and an organic dye, namely Dansyl group, which showed that the QDs present a much better contrast for imaging than the organic dye.
authors.affiliation: Department of Chemistry, University of Miami, 1301 Memorial Drive, Room 315, Coral Gables, FL 33124, USA. x.ji@umiami.edu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ji
authors.forename: David
authors.initials: D
authors.lastname: Naistat
authors.forename: Changqing
authors.initials: C
authors.lastname: Li
authors.forename: Jhony
authors.initials: J
authors.lastname: Orbulesco
authors.forename: Roger M
authors.initials: RM
authors.lastname: Leblanc
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000648:ultrastructure*; D002942:Circular Dichroism; D004396:Coloring Agents; D003619:Dansyl Compounds; D006801:Humans; D066298:In Vitro Techniques; D008856:Microscopy, Fluorescence; D010446:Peptide Fragments / Q000737:chemistry* / Q000648:ultrastructure*; D045663:Quantum Dots
chemical_list: D016229:Amyloid beta-Peptides; D004396:Coloring Agents; D003619:Dansyl Compounds; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); C113042:amyloid beta-protein (31-35); C033853:dansyl acid