Active viremia in rotavirus-infected mice.
Rotavirus circulates extraintestinally in animals used as models for rotavirus infection and in children. Rotavirus infection in mice was used to define host or viral factors that affect rotavirus viremia. Antigenemia was observed with homologous and heterologous rotaviruses, and neither age nor mouse strain genetics altered the occurrence of rotavirus antigenemia or viremia. Rotavirus RNA and infectious virus were present in sera and associated with the plasma fraction of blood in all infected mice. These findings indicate that antigenemia/viremia occurs routinely in rotavirus infections and imply that infectious rotavirus has access to any extraintestinal cell within contact of blood.
Blutt
Sarah E
SE
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Fenaux
Martijn
M
Warfield
Kelly L
KL
Greenberg
Harry B
HB
Conner
Margaret E
ME
D000818:Animals; D000956:Antigens, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D012367:RNA, Viral / Q000097:blood* / Q000276:immunology; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000097:blood* / Q000276:immunology; D013045:Species Specificity; D014766:Viremia / Q000276:immunology
D000956:Antigens, Viral; D012367:RNA, Viral