title: Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine.
abstract: A reliable and high-yielding procedure for preparation of 7-aryl and 7-heteroaryl derivatives of (+/-)-vasicine in two steps from the naturally occurring material is described. This protocol broadens the chemical space for selective modifications of the vasicine tricyclic structure, thereby making it a valuable starting point for the development of novel compound libraries with potentially beneficial biological profiles.
authors.affiliation: Chemical Diversity Research Institute, Khimki, Moscow Reg., 114401 Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Shevyakov
authors.forename: Olga I
authors.initials: OI
authors.lastname: Davydova
authors.forename: Dmitry G
authors.initials: DG
authors.lastname: Pershin
authors.forename: Mikhail
authors.initials: M
authors.lastname: Krasavin
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kravchenko
authors.forename: Alex
authors.initials: A
authors.lastname: Kiselyov
authors.forename: Sergey E
authors.initials: SE
authors.lastname: Tkachenko
authors.forename: Alexandre V
authors.initials: AV
authors.lastname: Ivachtchenko
mesh_terms: D000470:Alkaloids; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines
chemical_list: D000470:Alkaloids; D011799:Quinazolines; C019592:vasicine