Identification and characterization of a virus-inducible non-coding RNA in mouse brain.
Infection of mice with Japanese encephalitis virus or Rabies virus results in the activation of a gene encoding a novel, non-coding RNA (ncRNA) in the mouse central nervous system. This transcript, named virus-inducible ncRNA (VINC), is identical to a 3.18 kb transcript expressed in mouse neonate skin (GenBank accession no. AK028745) that, together with a number of unannotated cDNAs and expressed sequence tags, is grouped in the mouse unigene cluster Mm281895. VINC is expressed constitutively in early mouse embryo and several adult non-neuronal mouse tissues, as well as a murine renal adenocarcinoma (RAG) cell line. Northern blotting of nuclear and cytoplasmic RNAs revealed that VINC is localized primarily in the nucleus of RAG cells and is thus a novel member of the nuclear ncRNA family.
Saha
Sougata
S
Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Murthy
Sreenivasa
S
Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Rangarajan
Pundi N
PN
Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism* / Q000821:virology*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004664:Encephalitis Virus, Japanese / Q000472:pathogenicity*; D015870:Gene Expression; D051379:Mice; D008969:Molecular Sequence Data; D022661:RNA, Untranslated / Q000096:biosynthesis* / Q000235:genetics*; D011820:Rabies virus / Q000472:pathogenicity*; D014018:Tissue Distribution
D018076:DNA, Complementary; D022661:RNA, Untranslated