Near-wall deposition probability of blood elements as a new hemodynamic wall parameter.
The present study was performed to investigate deposition probability of blood particles on the vessel walls. To track dynamics of movement and adhesion of blood particles in the near wall region, two models such as the particle rolling model (PR-model) and the near wall force model (NWF-model) were employed in the present study. Simulations of the present models for the pre-activated platelets in the stagnated point flow chamber and for the pre-activated monocytes in the stenotic perfusion tube resulted in significant correlations with the experimental data. The proposed near wall deposition probability (NWDP) index exhibited good fits with the experimental data of the stagnation point flow chamber for the platelet. As for the monocyte, the NWDP index exhibited the best fit with the experimental data of the stenotic tube. The new hemodynamic index, NWDP, is different from the wall shear stress (WSS)-based hemodynamic parameters, such as MWSS (Mean Wall Shear Stress), AWSS (Amplitude of Wall Shear Stress), and OSI (Oscillatory Shear Index) in that it locates regions of both the high and low WSS. The proposed NWDP index needs to be tested and compared in real geometries for its effectiveness in locating regions of lesion-prone sites.
Kim
Min-Cheol
MC
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Korea.
Nam
Jin Hyun
JH
Lee
Chong-Sun
CS
D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001790:Blood Physiological Phenomena; D001792:Blood Platelets; D001794:Blood Pressure; D001809:Blood Viscosity; D016893:Carotid Stenosis / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009000:Monocytes; D010316:Particle Size; D015539:Platelet Activation