title: Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii.
abstract: Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: David
authors.initials: D
authors.lastname: Harrington
authors.forename: James L
authors.initials: JL
authors.lastname: Kohen
authors.forename: Subramanyam
authors.initials: S
authors.lastname: Vemulpad
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Jamie
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D041621:Eremophila Plant / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C514660:3,8-dihydroxyserrulatic acid; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; C514661:serrulatic acid