title: Leptin and resistin levels and their relationships with glucose metabolism in children with chronic renal insufficiency and undergoing dialysis.
abstract: OBJECTIVE
  The aim of the present study is: (i) to evaluate the serum concentrations of leptin and resistin in the paediatric patients with chronic renal impairment (CRI), on haemodialysis (HD) and on peritoneal dialysis (PD) treatment; (ii) to examine the relationship between these hormones; and (iii) to investigate the possible influence of these hormones on the insulin resistance and sensitivity indexes as well as on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels.
  
  
  METHODS
  In total, 52 patients (15 patients with CRI, 24 PD patients and 13 HD patients) and 23 healthy age- and sex-matched control subjects were included in the present study.
  
  
  RESULTS
  Homeostasis model assessment of insulin resistance (HOMA-IR) was higher than 2.5 in 47.1% of the patients. IGF-1 levels of patients with CRI, PD and HD patients were significantly lower than those in the controls (P < 0.001, P < 0.001, P < 0.001, respectively). The leptin levels of patients with CRI and on PD and HD treatment were significantly higher than the control group (P = 0.038, P = 0.002, P = 0.006, respectively). Similarly, serum resistin levels of patients with CRI and those of PD and HD patients were higher when compared with healthy controls (P = 0.037, P < 0.001, P = 0.005, respectively).
  
  
  CONCLUSIONS
  Leptin and resistin levels were increased in the children with CRF; however, this elevation was not found to be associated with hyperinsulinism. Further studies to explain the mechanisms and consequences of the accumulation of these hormones in CRF may provide the therapeutical approach aiming to normalize their circulating levels.
authors.affiliation: Department of Pediatric Nephrology, Gazi University, Ankara, Turkey. nbuyan@gazi.edu.tr
authors.forename: Necla
authors.initials: N
authors.lastname: Buyan
authors.forename: Buyan
authors.initials: B
authors.lastname: Necla
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Bideci
authors.initials: B
authors.lastname: Aysun
authors.forename: Ozan
authors.initials: O
authors.lastname: Ozkaya
authors.forename: Ozkaya
authors.initials: O
authors.lastname: Ozan
authors.forename: Erol
authors.initials: E
authors.lastname: Ortac
authors.forename: Ortac
authors.initials: O
authors.lastname: Erol
authors.forename: Sevcan
authors.initials: S
authors.lastname: Bakkaloglu
authors.forename: Bakkaloglu
authors.initials: B
authors.lastname: Sevcan
authors.forename: Sevim
authors.initials: S
authors.lastname: Gonen
authors.forename: Gonen
authors.initials: G
authors.lastname: Sevim
authors.forename: Harun
authors.initials: H
authors.lastname: Peru
authors.forename: Peru
authors.initials: P
authors.lastname: Harun
authors.forename: Oğuz
authors.initials: O
authors.lastname: Soylemezoglu
authors.forename: Soylemezoglu
authors.initials: S
authors.lastname: Oğuz
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.forename: Cinaz
authors.initials: C
authors.lastname: Peyami
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy*; D052243:Resistin / Q000097:blood*
chemical_list: D020738:Leptin; D052243:Resistin; D005947:Glucose