title: [Experimental research of biological inertness of nickel-titanium alloy with memory of the form].
abstract: Research was conducted on 26 adult outbred male and female mice, which were implanted with nickel-titanium wire in the paravertebral zone. The tissues surrounding the implants were studied macroscopically and histologically 2-8 months after the implantation. It was found that the morphological changes of tissues after nickel-titanium wire implantation were detected by microscopical study at the time intervals greater than 2 months after the operation. They included the formation of a thin connective tissue capsule in close vicinity to the implant. No signs of reactive changes in the distant tissues and organs were detected. It is concluded, that the nickel-titanium alloy possesses high degree of biological inertness and may be used for making fixating devices with the memory of mechanical shape that are employed in cranioreconstructive surgery.
authors.forename: D E
authors.initials: DE
authors.lastname: Matsko
authors.forename: E A
authors.initials: EA
authors.lastname: Davydov
authors.forename: Zh S
authors.initials: ZhS
authors.lastname: Zhanaĭdarov
authors.forename: A V
authors.initials: AV
authors.lastname: Klimash
authors.forename: A V
authors.initials: AV
authors.lastname: Omel'chenko
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D001854:Bone Marrow Cells / Q000166:cytology; D005260:Female; D008297:Male; D008422:Materials Testing; D051379:Mice; D008815:Mice, Inbred Strains; D009532:Nickel / Q000009:adverse effects*; D009969:Orthodontic Wires / Q000009:adverse effects*; D013131:Spine / Q000166:cytology; D014025:Titanium / Q000009:adverse effects*
chemical_list: D001672:Biocompatible Materials; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium