Parmacological regulation of erythropoietic precursor pool in experimental neuroses.
We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic precursors (directly and via interaction with adherent cells of the hemopoiesis-inducing environment). Under conditions of paradoxical sleep deprivation the absence of interaction between Thy 1,2+ cells and adherent bone marrow fraction disturbs erythroid colony formation. In experimental neuroses the state of erythropoietic precursors and secretory activity of elements of the hemopoiesis-inducing microenvironment are controlled by monoamines. The regulatory effect of monoamines is realized via adrenergic and erythropoietin-sensitive receptors on erythroid precursors and cells of the hemopoiesis-inducing microenvironment.
Skurikhin
E G
EG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Provalova
N V
NV
Pershina
O V
OV
Minakova
M Yu
MY
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002448:Cell Adhesion; D004195:Disease Models, Animal; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000378:metabolism; D006410:Hematopoiesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009497:Neurotic Disorders / Q000188:drug therapy*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
D015306:Biogenic Monoamines