CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement.
A 40-year-old previously healthy lady presented with nasal obstruction and localized plaques over the right arm. She developed complete nasal obstruction due to a mass in the right nasal cavity and skin lesions that ulcerated to present as ecthyma gangrenosum like lesions. Patient's condition deteriorated fast and she developed icterus with fatal outcome within 4 weeks of developing skin lesions. Nasal and skin biopsy revealed angiocentric T-cell lymphoma, which on immuno-phenotyping revealed CD-3 positive; and CD-20, CD-30, ALK and EMA negativity. She was seronegative for HIV. Final diagnosis of CD-3 positive extranodal T-cell lymphoma of nasal type was made. Extranodal T-cell lymphomas are very aggressive NHLs with poor prognosis. Prognosis depends on histology, stage of the disease and sites of involvement. NK/T cell lymphoma of nasal type is common with EBV association. Skin involvement is rare and is also an indicator of poor prognosis.
Reddy
Raghunatha R
RR
Department of Dermatology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India. raghupavi18@rediffmail.com
Singh
Gurcharan
G
Prathima
K J
KJ
Harendra Kumar
M L
ML
D000328:Adult; D017252:CD3 Complex / Q000378:metabolism; D004473:Ecthyma / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D009669:Nose Neoplasms / Q000209:etiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*
D017252:CD3 Complex