title: Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis.
abstract: Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhance the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at 37 degrees C using a Franz diffusion cell, and the ultrasound treatment was carried out for 10 h. The level of TA permeation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, 2.5 W/cm2), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.
authors.affiliation: Department of Pharmacy, Woosuk University, Samrye 565-701, Korea.
authors.forename: Jae-Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Dae-Keun
authors.initials: DK
authors.lastname: Kim
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Yun
authors.forename: Tae-Youl
authors.initials: TY
authors.lastname: Kim
authors.forename: Sang-Chul
authors.initials: SC
authors.lastname: Shin
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005782:Gels; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability; D015612:Phonophoresis / Q000379:methods*; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D012869:Skin Absorption; D012995:Solubility; D013696:Temperature; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000893:Anti-Inflammatory Agents; D005782:Gels; D014222:Triamcinolone Acetonide