title: Cognitive and motor function in people with multiple sclerosis in Stockholm County.
abstract: The aim of this study was to analyse cognitive and motor function in a population-based sample of people with multiple sclerosis (PwMS), taking into account both disease-related data and sociodemographic factors. Data were collected from 166 PwMS during home visits. Cognitive function was assessed by the Mini-Mental State Examination (MMSE), the Free Recall and Recognition of 12 Random Words Test (FRR12RWT), and the Symbol Digit Modalities Test (SDMT); manual dexterity by the Nine-Hole Peg Test (NHPT); global motor capacity by the Lindmark Motor Capacity Assessment; and walking capacity by a timed 10-metre walk. On cognitive tests, 55% (MMSE), 84% (FRR12RWT), and 45% (SDMT) of PwMS scored within the normal range; 27% of PwMS displayed normal manual dexterity, 9% had a maximal motorcapacity score, and 8% walked at normal speed. Factors associated with normal cognitive function were lower disability and higher education; lower disability and current employment were predictive of capacity to perform the NHPT and to walk 10 metres. In conclusion, cognitive function was normal in approximately half of the PwMS investigated, while a minority displayed normal manual dexterity and normal walking capacity. Thus, both disease severity and sociodemographic factors appear to influence cognitive and motor function in MS.
authors.affiliation: Division of Physiotherapy, Neurotec Department, Karolinska Institutet, S-141 86 Stockholm, Sweden. ulrika.einarsson@karolinska.se
authors.forename: U
authors.initials: U
authors.lastname: Einarsson
authors.forename: K
authors.initials: K
authors.lastname: Gottberg
authors.forename: L
authors.initials: L
authors.lastname: von Koch
authors.forename: S
authors.initials: S
authors.lastname: Fredrikson
authors.forename: C
authors.initials: C
authors.lastname: Ytterberg
authors.forename: Y-P
authors.initials: YP
authors.lastname: Jin
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: L Widén
authors.initials: LW
authors.lastname: Holmqvist
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D003071:Cognition; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009043:Motor Activity; D020528:Multiple Sclerosis, Chronic Progressive / Q000453:epidemiology / Q000503:physiopathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D015995:Prevalence; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology; D016138:Walking