title: [Experimental-clinical grounds for the treatment of granulating soft tissue wounds by the wound edge approximating stapler].
abstract: Factors of risk of the appearance of wound complications were studied in experiment on a model of granulating wounds in 18 mongrel dogs. A traditional method (control group) and an apparatus method (main group) were used for suturing the wounds. In the main group of animals suturing the wounds was performed after bringing together the wound edges by specially designed devices. Morphological and microbiological investigations have shown that the leading role in the appearance of complications belongs to the morphological substrate of the wound with the main component including the degree of traumatizing the paravulnerable tissue with a suture thread when connecting the wound edges by a traditional method, ischemia of the paravulnerable tissues under conditions of microbial dissemination. The introduction of the developed method of closing the soft tissue granulating wounds into clinical practice resulted in a statistically significant reduction of pyo-inflammatory complications in the main group of patients. A conclusion is made on a more favorable course of the wound process when using the apparatus method of closing the wounds.
authors.forename: S G
authors.initials: SG
authors.lastname: Izmaĭlov
authors.forename: V V
authors.initials: VV
authors.lastname: Beschastnov
authors.forename: A G
authors.initials: AG
authors.lastname: Izmaĭlov
authors.forename: A A
authors.initials: AA
authors.lastname: Artifektsova
authors.forename: E V
authors.initials: EV
authors.lastname: Beliaeva
authors.forename: V N
authors.initials: VN
authors.lastname: Garaev
authors.forename: D S
authors.initials: DS
authors.lastname: Lediaev
authors.forename: A A
authors.initials: AA
authors.lastname: Botiakov
authors.forename: T S
authors.initials: TS
authors.lastname: Izmaĭlova
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D006097:Granulation Tissue / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017695:Soft Tissue Injuries / Q000473:pathology / Q000601:surgery*; D013528:Surgical Staplers; D013536:Suture Techniques / Q000295:instrumentation*