Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects.
We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.
Mahé
Emmanuel
E
Department of Dermatology, Bichat-Claude Bernard University Hospital, Paris, France. emmanuel.mahe@apr.aphp.fr
Morelon
Emmanuel
E
Lechaton
Sophie
S
Drappier
Jean-Christophe
JC
de Prost
Yves
Y
Kreis
Henri
H
Bodemer
Christine
C
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D020123:Sirolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D020123:Sirolimus