[Protective activity of adsorbed D(a)PT vaccine with the acellular pertussis component and polyoxydonium].
The introduction of the immunomodulator polyoxidonium in an amount of 0.5 Mg/ml into adsorbed D(a)PT vaccine with the acellular pertussis component leads to the preservation of the protective activity of the pertusis component, diphtheria and tetanus toxoids, as well to the 4-time decrease of the content of adsorbent (aluminium hydroxide) from 2 to 0.5 mg/ml.
Zakharova
N S
NS
Britsina
M V
MV
Ozeretskovskaia
M N
MN
Bazhanova
I G
IG
Mertsalova
N U
NU
Poddubikov
A V
AV
Zaĭtsev
E M
EM
Ermolova
E V
EV
D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000818:Animals; D004165:Diphtheria / Q000517:prevention & control*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007279:Injections, Subcutaneous; D051379:Mice; D009930:Organic Chemicals / Q000008:administration & dosage; D013742:Tetanus / Q000517:prevention & control*; D014611:Vaccination; D014917:Whooping Cough / Q000517:prevention & control*
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D009930:Organic Chemicals; C089921:polyoxydonium; D000536:Aluminum Hydroxide