Lung donors selection criteria: a review.
Lung transplantation has had increasing success worldwide and it became an acceptable treatment modality in end-stage pulmonary diseases. The insufficient supply of donor lungs, resulting in prolonged waiting time, and the significant rise of patients on the waiting list, have forced the most experienced transplantation centers to redefine the acceptable lung donor criteria including marginal allografts. Existing standard lung donor criteria have been established in the first period of lung transplantation activity, based mainly on opinions and individual experiences rather than on existing evidences: the paucity of donors may be also explained by the rigid application of these criteria. The quality of donor organs has a significant impact on early and long-term recipient outcome. Recent studies have demonstrated that the use of marginal donors did not affect early and late recipient outcome, and significantly increased the number of transplants performed. The aim of this paper is to review how the main lung donor selection criteria have been changed and how they influence the recipient outcome.
Filosso
P L
PL
Department of Thoracic Surgery, Lung Transplant Program, University of Turin, Turin, Italy. pierluigifilosso@tiscalinet.it
Turello
D
D
Cavallo
A
A
Ruffini
E
E
Mancuso
M
M
Oliaro
A
A
D001926:Brain Death / Q000503:physiopathology; D002102:Cadaver; D046148:Donor Selection; D006801:Humans; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation; D011652:Pulmonary Circulation