title: A comparison of the sensitivity of flow cytometry and bone marrow biopsy in the detection of minimal residual disease in chronic lymphocytic leukemia.
abstract: We compared the sensitivity of bone marrow biopsy to blood flow cytometry in detecting minimal residual disease (MRD) in 29 patients with chronic lymphocytic leukemia (CLL) in clinical remission after treatment. These results demonstrate that flow cytometry is more sensitive than bone marrow biopsy in detecting MRD and in predicting relapse in CLL.
authors.forename: Karim
authors.initials: K
authors.lastname: Maloum
authors.forename: Frédéric
authors.initials: F
authors.lastname: Charlotte
authors.forename: Marine
authors.initials: M
authors.lastname: Divine
authors.forename: Bruno
authors.initials: B
authors.lastname: Cazin
authors.forename: Claude
authors.initials: C
authors.lastname: Lesty
authors.forename: Hélène
authors.initials: H
authors.lastname: Merle-Béral
mesh_terms: D001706:Biopsy / Q000379:methods*; D001854:Bone Marrow Cells / Q000473:pathology*; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D018365:Neoplasm, Residual / Q000473:pathology*; D012680:Sensitivity and Specificity