title: Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
abstract: Patent ductus arteriosus is one of the most common congenital abnormalities found in premature infants. Ibuprofen, a nonsteroidal drug that is commonly used as an antipyretic, analgesic and anti-inflammatory agent, is also used to induce closure of symptomatic patent ductus arteriosus in preterm infants. Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension. Only 3 cases of pulmonary hypertension following early administration of an ibuprofen solution buffered with tromethamine have previously been reported. However, this severe side effect has never been observed in multicentre, randomized, double-blind controlled trials, nor in recent reviews or meta-analyses of L-lysine ibuprofen use.
authors.affiliation: Neonatal Intensive Care Unit, Department of Pediatrics, University of Genoa, Gaslini Institute, Genoa, Italy. carlobellini@ospedale-gaslini.ge.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Bellini
authors.forename: Francesco
authors.initials: F
authors.lastname: Campone
authors.forename: Giovanni
authors.initials: G
authors.lastname: Serra
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D000860:Hypoxia / Q000139:chemically induced; D007052:Ibuprofen / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008239:Lysine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008239:Lysine; D007052:Ibuprofen