title: Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum.
abstract: A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.
authors.affiliation: Department of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rigano
authors.forename: Armando
authors.initials: A
authors.lastname: Grassia
authors.forename: Francesca
authors.initials: F
authors.lastname: Borrelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Aviello
authors.forename: Franco
authors.initials: F
authors.lastname: Piozzi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
authors.forename: Nelly Apostolides
authors.initials: NA
authors.lastname: Arnold
authors.forename: Raffaele
authors.initials: R
authors.lastname: Capasso
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015153:Blotting, Western; D002351:Carrageenan; D015232:Dinoprostone / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D027522:Marrubium; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D052247:Nitric Oxide Synthase Type II; D015232:Dinoprostone