[Progress in mechanism of microcystin toxicity].
Microcystin is one of the monocyclic heptapeptides produced primarily by microcystis aeruginosa. Recent studies suggest that microcystin can induce cell apoptosis, as well as oxidative stress and mitochondrial alteration. Studies also indicate that Bcl-2 family and p53 may play an important role in the apoptosis induced by microcystin.
Fu
Wen-yu
WY
Department of Biochemistry and Molecular Biology, Institute of Occupational and Environmental Health, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Xu
Li-hong
LH
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D052998:Microcystins / Q000633:toxicity*; D046931:Microcystis / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D052998:Microcystins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C078588:microcystin