Plasma cell leukemia presenting with diplopia due to unilateral abducens paralysis and complex chromosomal abnormalities.
Involvement of cranial nerves is rare in plasma cell leukemia (PCL). Here, we report a case of PCL presenting with unilateral abducens paralysis. Cranial magnetic resonance imaging (MRI) disclosed a mass in the sphenoid sinus. Although the patient showed an initial response to chemotherapy, he died of disease progression 5 months later. Cytogenetic analysis showed translocation of chromosomes 11 and 14, t(11;14) (q13;q32), with additional complex abnormalities. This case implies an association between clinical manifestations and chromosomal abnormalities.
Nakaya
Aya
A
Department of Internal Medicine, Hiratsuka City Hospital, Hiratsuka.
Ogihara
Tohru
T
Awaya
Norihiro
N
D020434:Abducens Nerve Diseases / Q000150:complications*; D000368:Aged; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D004172:Diplopia / Q000209:etiology*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D010243:Paralysis / Q000150:complications*; D013101:Sphenoid Sinus / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic