title: Integrating microarray gene expression object model and clinical document architecture for cancer genomics research.
abstract: Systematic integration of genomic-scale expression profiles with clinical information may facilitate cancer genomics research. MAGE-OM (Microarray Gene Expression Object Model) defines standard objects for genomic but not for clinical data. HL7 CDA (Clinical Document Architecture) is a document model for clinical information, describing syntax (generic structure) but not semantics. We designed a document template in XML Schema with additional constraints for CDA to define content semantics, enabling data model-level integration of MAGE-OM and CDA for cancer genomics research.
authors.affiliation: Seoul National University Biomedical Informatics (SNUBI) and Human Genome Research Institute, Seoul National University College of Medicine, Seoul, 110-799, Korea.
authors.forename: Yu Rang
authors.initials: YR
authors.lastname: Park
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Ju Han
authors.initials: JH
authors.lastname: Kim
mesh_terms: D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011381:Programming Languages; D012660:Semantics