Cellulose acetate/chitosan multimicrospheres preparation and ranitidine hydrochloride release in vitro.
A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200-350 microm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers.
Zhou
Hui Yun
HY
College of Marine Life Science, Ocean University of China, Qingdao, PR, China.
Chen
Xi Guang
XG
Liu
Cheng Sheng
CS
Meng
Xiang Hong
XH
Liu
Chen Guang
CG
He
Jun
J
Yu
Le Jun
le J
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D011899:Ranitidine / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D003692:Delayed-Action Preparations; D006635:Histamine H2 Antagonists; C005062:acetylcellulose; D011899:Ranitidine; D002482:Cellulose; D048271:Chitosan