[Antibodies to the infective agents of opportunistic infections in blood of patients with hemoblastosis complicated with pneumonia].
The examination of 112 hematological patients with diagnosed acute and chronic leucosis, lymphoma, myeloma, anemia, melanoma and other diseases revealed not a single subject among these examinees in whom no markers of opportunistic infections were detected. Low titers of antibodies to Pneumocystis carinii, cytomegalovirus (CMV), Epstein-Barr virus (EBV) were noted in 42%, 46.4% and 40.2% of examinees, respectively. Markers of acute diseases, such as class IgM, IgG antibodies in high titers, as well as P.carinii, CMV, EBV antigens, were detected in 37.5%, 30.4% and 22.3% of patients of a hematological hospital. In the group of comparison (donors) these figures were, respectively, 15.3%, 2.4% and 6.9%. The signs of monoinfection were detected in 11.6% (pneumocystosis), in 10.7% (CMV infection) and in 14.3% (EBV infection), while the markers of two infections, EBV infection and pneumocystosis, were detected in 9.8%, EBV and CMV infections in 11.6%, pneumocystosis and CMV infection in 14.3%; mixed contamination with all three infective agents was detected in 12.5% of the patients.
Bosh'ian
R E
RE
Rybalkina
T N
TN
Karazhas
N V
NV
Ermakova
T M
TM
Galstian
G M
GM
Osmanov
E A
EA
Vorob'ev
A A
AA
D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D000946:Antigens, Fungal / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006785:Hospitals, University; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D045363:Pneumocystis carinii / Q000276:immunology*; D011020:Pneumonia, Pneumocystis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D011024:Pneumonia, Viral / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D012426:Russia
D000908:Antibodies, Fungal; D000914:Antibodies, Viral; D000946:Antigens, Fungal; D000956:Antigens, Viral; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M