title: Assessment of bone structure and acoustic impedance in C3H and BL6 mice using high resolution scanning acoustic microscopy.
abstract: Two hundred-MHz time-resolved scanning acoustic microscopy was applied for the investigation of acoustic and structural bone properties of mice from two inbred strains. Transverse sections of femur taken from 5 C57BL/6J@Ico and 5 C3H/HeJ@Ico mice were explored. Both strains had the same bone diameter, but the C3H/HeJ@Ico mice had greater cortical thickness, smaller cancellous diameter, and greater acoustic impedance values than C57BL/6J@Ico mice. The strong differences in the measured acoustic impedances among the two inbred strains indicate that the impedance is a good parameter to detect genetic variations of the skeletal phenotype in small animal models.
authors.affiliation: Laboratoire d'Imagerie Paramétrique, CNRS/Université Paris 6, UMR 7623, 15, Paris, France.
authors.forename: Tobias
authors.initials: T
authors.lastname: Hofman
authors.forename: Kay
authors.initials: K
authors.lastname: Raum
authors.forename: Ingrid
authors.initials: I
authors.lastname: Leguerney
authors.forename: Amena
authors.initials: A
authors.lastname: Saïed
authors.forename: Françoise
authors.initials: F
authors.lastname: Peyrin
authors.forename: Laurence
authors.initials: L
authors.lastname: Vico
authors.forename: Pascal
authors.initials: P
authors.lastname: Laugier
mesh_terms: D000818:Animals; D002113:Calcification, Physiologic / Q000502:physiology*; D017097:Electric Impedance; D005269:Femur / Q000000981:diagnostic imaging* / Q000502:physiology*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D033401:Microscopy, Acoustic / Q000379:methods*