[House-dust mites allergen for specific immunotherapy by oral administration: experimental study].
The oral medicinal form of house-dust allergen has been prepared with the use of new technology. To produce the preparation, the standard water-saline extract obtained from house-dust mites (Dermatophagoides farinae) allergen has been used. This preparation is chemically stable and does not lose its biological activity for 2 - 3 years of storage. The microbiological purity of the allergen meets the requirements for oral preparations. The allergen has proved to be safe in cases of prolonged administration and has no chronic toxicity. As shown with the use of immunochemical methods, the preparation has high immunogenicity and lower allergenicity. This preparation may be recommended for clinical trials on a limited circle of subjects.
Berzhets
V M
VM
Koreneva
E A
EA
Khlgatian
S V
SV
Petrova
N S
NS
Berzhets
A I
AI
Zhirova
S N
SN
D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity; D040001:Dermatophagoides farinae / Q000737:chemistry / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000628:therapy*; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy; D051379:Mice; D011506:Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014020:Tissue Extracts / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
D000485:Allergens; D007074:Immunoglobulin G; D011506:Proteins; D014020:Tissue Extracts