A case of breast cancer metastatic to the tail of the pancreas.
Breast cancer metastasis to pancreas is rarely seen. There have been only 6 cases described in the literature. We present the seventh case of a 54-year-old woman with breast cancer that metastasized to the tail of the pancreas 4 years and 4 months after radical mastectomy. Although the serum levels of CA15-3 and TPA had gradually increased without symptoms, it was difficult to establish the diagnosis before contrast-enhanced abdominal CT scan was performed. Immunohistochemical staining using E-cadherin was positive, proving that the breast cancer was ductal rather than lobular in origin. CA15-3 immunohistochemically stained positive in the resected pancreas lesion. Positive monoclonal staining by GCDFP-15 (gross cystic disease fluid protein-15) in the pancreas tumor also confirmed it breast cancer origin. Investigation of chemokine/chemokine receptors may clarify a new mechanism of metastasis to the pancreas from breast cancer.
Tohnosu
Noriyuki
N
Department of Surgery, Funabashi Municipal Medical Center, Chiba, Japan.
Narushima
Kazuo
K
Sunouchi
Keita
K
Saito
Takeshi
T
Shimizu
Takanori
T
Tanaka
Hajime
H
Maruyama
Takashi
T
Watanabe
Yoshiji
Y
Kato
Taku
T
Shimizu
Shinichiro
S
Uehara
Toshitaka
T
Ishii
Satoru
S
D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000628:therapy; D018570:Risk Assessment; D016896:Treatment Outcome