title: Are i-STAT results adversely affected by an artificial blood substitute in vivo?
abstract: The purpose of this study was to determine whether i-STAT measurements on blood treated with hemoglobin-based oxygen carrier-201 (HBOC-201) would provide laboratory test results comparable to those achieved with a known reliable piece of equipment (Radiometer) for swine blood treated with HBOC-201. HBOC-201 is an artificial blood substitute solution being considered for use by medics in the field for the treatment of combat casualties. The i-STAT is a portable compact piece of laboratory equipment used for rapid assessment of blood samples under field conditions, instead of larger, hospital-based, laboratory equipment. Blood from pigs was obtained before and after administration of HBOC-201. The blood was tested with the i-STAT and the Radiometer. No drastic inaccuracy in test results with the i-STAT can be predicted for battlefield casualty care with potential HBOC-201 use, because laboratory results with the i-STAT and Radiometer were comparable with respect to blood testing after the administration of HBOC-201.
authors.affiliation: 59th Clinical Research Squadron, Wilford Hall Medical Center, Lackland AFB, TX 78253, USA.
authors.forename: Roy R
authors.initials: RR
authors.lastname: Estrada
mesh_terms: D000818:Animals; D001802:Blood Substitutes; D006403:Hematologic Tests / Q000295:instrumentation* / Q000592:standards*; D006454:Hemoglobins / Q000032:analysis*; D013552:Swine / Q000097:blood; D014481:United States; D014857:Warfare
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C096798:HBOC 201