Pharmacological regulation of functional activity of stem cells in restoration of the myocardium during the postinfarction period.
The effect of granulocytic CSF on myocardial tissue recovery after acute myocardial infarction was studied on rats. A course of granulocytic CSF after ligation of the left coronary artery normalized ECG parameters and morphological picture of the myocardium 1 month after treatment. It was shown on mouse model of myocardial infarction that this process was associated with more intensive mobilization and homing of mesenchymal stem cells in the heart.
Stavrova
L A
LA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Fomina
T I
TI
Plotnikov
M B
MB
Aliev
O I
OI
Sotnikova
N V
NV
Epstein
O I
OI
Sergeeva
S A
SA
Gur'yantseva
L A
LA
Zyuz'kov
G N
GN
Zhdanov
V V
VV
Dygai
A M
AM
Gol'dberg
E G
EG
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002555:Cerebrospinal Fluid / Q000378:metabolism; D003331:Coronary Vessels / Q000473:pathology; D004562:Electrocardiography; D006098:Granulocytes / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000166:cytology*