title: [Influence of tumor location in patients with breast cancer on the sentinel node detection].
abstract: OBJECTIVE
  To evaluate the influence of tumour quadrant localization on the sentinel node (SN) detection and the visualisation of internal mammary chain (IM) drainage by radioisotopic techniques. 316 patients with breast cancer were studied. Mean age 57 years (range 29-88). All patients received 37-74 MBq of 99mTc-albumin nanocolloid in 2 ml by peritumoral injection. The breast cancer was located in the upper outer quadrant in 189 patients, in the upper inner in 57, in the lower outer in 57, in the lower inner in 55 and in the subareolar area in 18 patients. At two hours p.i., anterior and lateral chest lymphographies were obtained. The SN location was marked on the patient skin with permanent ink. SN was identified intraoperatively by the gamma probe. Histopatological analysis included imprints, delayed hematoxilin-eosin, inmunohistochemistry CAM 19-2 and PCR.
  
  
  RESULTS
  The scintigraphy and surgical detection was in the upper outer quadrant of 90 % and 93 % respectively; in the lower outer quadrant of 91 % and 95 %, in the upper inner quadrant of 93 % and 95 %, in the lower inner quadrant 87 % and 95 % and in the subareolar area in 94 % and 83 %. The IM chain drainage was of 6 % in the UO, in the LO of 5 %, in the UI of 12 %, in the LI of 20 % and none in subareolar.
  
  
  CONCLUSIONS
  Our data suggest that sentinel node location (quadrant) is not a influential factor in the scintigraphy and surgical detection. Tumours localised in internal quadrant show a higher rate of IM chain drainage.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario de Tenerife, La Laguna, Tenerife. chusgonzalez2004@yahoo.es
authors.forename: M J
authors.initials: MJ
authors.lastname: González-Soto
authors.forename: M T
authors.initials: MT
authors.lastname: Bajén
authors.forename: M J
authors.initials: MJ
authors.lastname: Pla
authors.forename: D
authors.initials: D
authors.lastname: Carrera
authors.forename: D
authors.initials: D
authors.lastname: Gil
authors.forename: E
authors.initials: E
authors.lastname: Benito
authors.forename: Y
authors.initials: Y
authors.lastname: Ricart
authors.forename: M
authors.initials: M
authors.lastname: Roca
authors.forename: J
authors.initials: J
authors.lastname: Martín-Comín
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007430:Intraoperative Care; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008348:Manikins; D015412:Mastectomy, Segmental; D008875:Middle Aged; D010173:Palpation; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy