Regulating cellular oxygen sensing by hydroxylation.
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.
Fandrey
Joachim
J
Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany. joachim.fandrey@uni-due.de
Gorr
Thomas A
TA
Gassmann
Max
M
D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology*; D002952:Citric Acid Cycle; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D006900:Hydroxylation; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D051793:Hypoxia-Inducible Factor 1; D008565:Membrane Proteins; D017382:Reactive Oxygen Species; D006899:Mixed Function Oxygenases; D010100:Oxygen