title: [Expression and significance of gonadotropin-releasing hormone receptor in the endometrium of normal and endometrial cancer uterus].
abstract: OBJECTIVE
  To investigate the expression of gonadotropin-releasing hormone receptor (GnRH-R) mRNA in the endometrium of normal and endometrial cancer uterus.
  
  
  METHODS
  In situ hybridization was used to detect the expression of GnRH-R mRNA in 23 cases of normal endometrium in hyperplasic phase, 30 cases of normal endometrium in secretory phase, and 30 cases of endometrium from endometrial cancer.
  
  
  RESULTS
  The results showed that GnRH-R mRNA was expressed in the cytoplasm of endometrium of normal and endometrial cancer uterus. There was no expression in the nuclei. There was no significant difference (P > 0.05) in the expression rate between the hyperplasic phase (17%, 4/23) and the secretory phase (17%, 5/30) in normal uterus. The expression rate in endometrial cancer was 40% (12/30), which was significantly higher than normal endometrium (P < 0.05).
  
  
  CONCLUSIONS
  The data demonstrates that GnRH may act directly on endometrium. GnRH-R is highly expressed in the endometrium of endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, First Hospital Jilin University, Changchun 130021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yue
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Piao
authors.forename: Li-na
authors.initials: LN
authors.lastname: Wang
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Pu
authors.forename: Feng-dong
authors.initials: FD
authors.lastname: Gao
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011966:Receptors, LHRH / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D011966:Receptors, LHRH