[Establishment of a pig model of chronic ally enhanced external counterpulsation].
OBJECTIVE
To establish a pig model of chronic external counterpulsation.


METHODS
Twelve pigs were anaesthetized with sodium pentobarbital (< or =30 mg/kg.b.w.) and 846 mixture (< or =0.1 ml/kg.b.w.) and counterpulsed in a lateral position for 2 h every two days (totally 36 h) with 0.025 to 0.04 MPa/cm(2) pressure.


RESULTS
External counterpulsation was successfully completed in all the animals. Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera (the liver, kidney and heart, etc).


CONCLUSIONS
The pig model of chronic external counterpulsation has been successfully established. Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.
Chen
Xiao-lin
XL
Department of Cardiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510089, China. cxlmce68@yahoo.com.cn
He
Xiao-hong
XH
Zhang
Yan
Y
Qian
Yue-tao
YT
Liang
Lu-guang
LG
Fang
Dian-qiu
DQ
Zhan
Cheng-yang
CY
Zheng
Zhen-sheng
ZS
Ma
Hong
H
D000768:Anesthesia, General / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D001243:Assisted Circulation; D015908:Counterpulsation / Q000379:methods*; D023421:Models, Animal; D010424:Pentobarbital / Q000008:administration & dosage; D013552:Swine
D010424:Pentobarbital