Neuropathologic findings in essential tremor.
Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.
Louis
E D
ED
GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. EDL2@columbia.edu
Vonsattel
J P G
JP
Honig
L S
LS
Ross
G W
GW
Lyons
K E
KE
Pahwa
R
R
D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D020329:Essential Tremor / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male