Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and control.
The objective of the current study was to analyze the neural correlates of behavioral arousal and inhibitory control as they relate to individual differences in impulsivity via well-established functional MRI amygdala reactivity and prefrontal inhibitory control paradigms in healthy adult subjects. Impulsivity correlated positively with activity of the bilateral ventral amygdala, parahippocampal gyrus, dorsal anterior cingulate gyrus (BA 32), and bilateral caudate. Conversely, impulsivity correlated negatively with activity of the dorsal amygdala and ventral prefrontal cortex (BA 47). Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits.
Brown
Sarah M
SM
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Manuck
Stephen B
SB
Flory
Janine D
JD
Hariri
Ahmad R
AR
D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012720:Severity of Illness Index; D012927:Social Control, Informal