title: Automatic detection of spironolactone - related adverse drug events.
abstract: Due to increasing reports of spironolactone associated life-threatening hyperkalemia, we implemented a rule in our automated event detection system to monitor serum potassium results in patients receiving spironolactone. In 2004, 419 (10.49%) of 3995 admissions at 3 BJC HealthCare hospitals were identified as having hyperkalemia while on spironolactone. For a 9-month period in one facility, 33 of 52 automatically detected potential ADEs had been validated by pharmacists through manual chart review to have spironolactone as a contributing factor (PPV=63.5%).
authors.affiliation: BJC HealthCare, St. Louis, Missouri, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Huang
authors.forename: Laura A
authors.initials: LA
authors.lastname: Noirot
authors.forename: Richard M
authors.initials: RM
authors.lastname: Reichley
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Bouselli
authors.forename: Wm Claiborne
authors.initials: WC
authors.lastname: Dunagan
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bailey
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D004232:Diuretics / Q000009:adverse effects*; D006751:Hospital Information Systems; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced / Q000175:diagnosis*; D008491:Medical Informatics Applications; D008510:Medication Systems, Hospital; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D004232:Diuretics; D013148:Spironolactone