Multi-protein complexes at the beta-globin locus.
Biochemical analysis of the beta-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the beta-globin gene expression.
Mahajan
Milind C
MC
Department of Genetics, The Anlyan Center, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06510, USA.
Weissman
Sherman M
SM
D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics*; D006801:Humans; D038101:Insulator Elements; D019901:Locus Control Region; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D046912:Multiprotein Complexes; D014157:Transcription Factors; D005914:Globins