Goat SRY induces testis development in XX transgenic mice.
The testis-determining gene SRY is not well-conserved among mammals, particularly between mouse and other mammals, both in terms of protein structure and of expression regulation. To evaluate SRY phylogenic conservation in regards to its function, we expressed the goat gene (gSRY) in XX transgenic mouse gonads. Here, we show that gSRY induces testis formation, despite a goat expression profile. Our results demonstrate that sex-reversal can be induced in XX-mice by a non-mouse SRY thus suggesting a conserved molecular mechanism of action of this testis-determining gene across mammalian species.
Pannetier
Maëlle
M
INRA, Biologie du Développement et Reproduction, Bât. J. Poly, 78350 Jouy-en-Josas, France.
Tilly
Gaëlle
G
Kocer
Ayhan
A
Hudrisier
Marthe
M
Renault
Lauriane
L
Chesnais
Nathalie
N
Costa
José
J
Le Provost
Fabienne
F
Vaiman
Daniel
D
Vilotte
Jean-Luc
JL
Pailhoux
Eric
E
D000375:Aging / Q000502:physiology; D000818:Animals; D003001:Cloning, Molecular; D012734:Disorders of Sex Development; D005260:Female; D015723:Gene Library; D006041:Goats; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D051876:Sex-Determining Region Y Protein / Q000235:genetics / Q000378:metabolism*; D013737:Testis / Q000254:growth & development* / Q000378:metabolism*; D014960:X Chromosome / Q000235:genetics*
D051876:Sex-Determining Region Y Protein