Phenoxodiol, a novel approach for the treatment of ovarian cancer.
Epithelial ovarian cancer is the fourth leading cause of cancer-related deaths in women and is the most lethal of the gynecological malignancies. Thle high mortality rate arises from difficulties in the early detection of the disease and the widespread development of chemoresistance. Phenoxodiol, a novel isoflavone derivative, has demonstrated antitumor activity. In addition, it has been shown to induce cell death in chemoresistant epithelial ovarian cancer cells. Moreover, suboptimal exposure of these cells to phenoxodiol lowered the IC50 value of numerous chemotherapeutic agents. In this review, the current understanding of the mechanism of action of phenoxodiol, its potential clinical application for the treatment of ovarian cancer and the concept of chemosensitization are discussed.
Mor
Gil
G
Yale University, Department of Obstetrics and Gynecology and Reproductive Science, School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Gil.Mor@yale.edu
Fu
Han-Hsuan
HH
Alvero
Ayesha B
AB
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004353:Drug Evaluation, Preclinical; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000378:metabolism
D000970:Antineoplastic Agents; D053418:Death Domain Receptor Signaling Adaptor Proteins; D007529:Isoflavones; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; C471183:phenoxodiol; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases