title: Prenatal detection of microtia by MRI in a fetus with trisomy 22.
abstract: Trisomy 22 is a rare chromosomal abnormality infrequently detected prenatally. External ear abnormalities, in particular microtia, are often associated with trisomy 22, but prenatal detection of microtia has not been reported in association with trisomy 22. We report a fetus with trisomy 22, with fetal MRI findings of microtia, craniofacial dysmorphism, and polygyria. Fetal MRI is a useful tool for auricular assessment and might have utility in the prenatal detection of chromosomal abnormalities, especially among fetuses with structural anomalies.
authors.affiliation: Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Milic
authors.forename: Susan
authors.initials: S
authors.lastname: Blaser
authors.forename: Ashley
authors.initials: A
authors.lastname: Robinson
authors.forename: Sandra
authors.initials: S
authors.lastname: Viero
authors.forename: William
authors.initials: W
authors.lastname: Halliday
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Winsor
authors.forename: Ants
authors.initials: A
authors.lastname: Toi
authors.forename: Micki
authors.initials: M
authors.lastname: Thomas
authors.forename: David
authors.initials: D
authors.lastname: Chitayat
mesh_terms: D001344:Autopsy; D002892:Chromosomes, Human, Pair 22; D004431:Ear, External / Q000002:abnormalities*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis*