Inhibition of photosystem II electron transport by acyl derivatives of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid).
In the course of the synthesis of gamma-pyrones, well-known inhibitors of photosystem II electron transport, it turned out that the starting material, acyl derivatives of 2,2-dimethyl-1,3-dioxane-5,6-dione (Meldrum's acid) are potent inhibitors of photosystem II electron transport. Thus, in a simple one-step synthesis from commercial available substances, highly potent photosystem II inhibitors are generated. The biological activity of the acyl derivatives is in a parabolic fashion dependent from the length of the alkyl side chain.
Oettmeier
Walter
W
Lehrstuhl Biochemie der Pflanzen, Ruhr-Universität, Bochum, Germany. walter.oettmeier@ruhr-uni-bochum.de
Jäger
Johannes
J
Masson
Klaus
K
D004146:Dioxanes / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D045332:Photosystem II Protein Complex / Q000037:antagonists & inhibitors*
D004146:Dioxanes; D004791:Enzyme Inhibitors; D045332:Photosystem II Protein Complex; C076489:Meldrum's acid