title: Translational stroke research in the developing brain.
abstract: Preclinical animal models can help guide the development of clinical pediatric and newborn stroke trials. Data obtained using currently available models of hypoxia-ischemia and focal stroke have demonstrated the need for age-appropriate models. There are age-related differences in susceptibility of the immature brain to oxidative stress and inflammation, as well as in the rate and degree of apoptotic neuronal death. These issues need to be carefully addressed in designing future clinical trials.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, California 94143-0663, USA. zinaida@atsa.ucsf.edu
authors.forename: Zinaida S
authors.initials: ZS
authors.lastname: Vexler
authors.forename: Frank R
authors.initials: FR
authors.lastname: Sharp
authors.forename: Giora Z
authors.initials: GZ
authors.lastname: Feuerstein
authors.forename: Stephen
authors.initials: S
authors.lastname: Ashwal
authors.forename: Marianne
authors.initials: M
authors.lastname: Thoresen
authors.forename: Jerome Y
authors.initials: JY
authors.lastname: Yager
authors.forename: Donna M
authors.initials: DM
authors.lastname: Ferriero
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D012107:Research Design; D020521:Stroke / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*