title: Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results.
abstract: BACKGROUND
  We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA).
  
  
  OBJECTIVE
  Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA.
  
  
  METHODS
  Men with AGA were randomized to receive finasteride (1 mg/d) or placebo for 192 weeks. Results of the second (weeks 96-144) and third (weeks 144-192) extension periods are reported.
  
  
  RESULTS
  Finasteride increased hair weight at 144 and 192 weeks (week 192: finasteride, 21.6% increase from baseline; placebo, 24.5% decrease from baseline; net increase in hair weight for finasteride vs placebo = 46.0%, P < .001). Hair count also increased with finasteride at 144 and 192 weeks (week 192: finasteride, 7.2% increase from baseline; placebo, 13.0% decrease from baseline; net increase in hair count for finasteride vs placebo = 20.3%, P < .05). Finasteride was generally well tolerated.
  
  
  CONCLUSIONS
  Because this study was extended from its original 48-week duration to nearly 4 years, the sample size available for analysis decreased with time.
  
  
  CONCLUSIONS
  Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men.
authors.affiliation: Department of Dermatology, University of California, San Francisco 94117, USA. pricev@derm.ucsf.edu
authors.forename: Vera H
authors.initials: VH
authors.lastname: Price
authors.forename: Emory
authors.initials: E
authors.lastname: Menefee
authors.forename: Matilde
authors.initials: M
authors.lastname: Sanchez
authors.forename: Keith D
authors.initials: KD
authors.lastname: Kaufman
mesh_terms: D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D018120:Finasteride / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006197:Hair / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D018120:Finasteride