Evaluation of mutagenic activity of dioxazid by the polyorgan micronuclear method in experiments on rats.
The mutagenic effect of antituberculous drug dioxazid was studied on rats receiving this preparation in a dose of 25 mg/kg (in conversion to dioxidine) via inhalation route for 3 months. The percentage of cells with micronuclei and the content of polychromatophilic erythrocytes among all bone marrow erythrocytes and percentage of cells with micronuclei, protrusions, and binucleated cells in the lungs and urinary bladder were evaluated. Dioxazid caused no changes in organs, except the increase in the percentage of binucleated cells in bladder epithelium, which attests to minor cytotoxic effect of the drug for this organ.
Sycheva
L P
LP
Laboratory of Genetic Monitoring, A. N. Sysin Institute of Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences, Moscow. lpsycheva@mail.ru
Sharova
S A
SA
Kovalenko
M A
MA
Sheremet'eva
S M
SM
Zhurkov
V S
VS
D000280:Administration, Inhalation; D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D003582:Cytogenetics; D004338:Drug Combinations; D004912:Erythrocytes / Q000378:metabolism; D007538:Isoniazid / Q000737:chemistry*; D008168:Lung / Q000378:metabolism; D008297:Male; D015162:Micronucleus Tests / Q000379:methods*; D016296:Mutagenesis; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens; D011810:Quinoxalines / Q000737:chemistry*; D051381:Rats; D013997:Time Factors; D001743:Urinary Bladder / Q000378:metabolism
D000995:Antitubercular Agents; D004338:Drug Combinations; D009153:Mutagens; D011810:Quinoxalines; C513230:dioxazid; C001077:dioxidine; D007538:Isoniazid