title: [Role of bone gammagraphy in the diagnosis of secondary osteomalacia in a patient treated with tenofovir].
abstract: It is reported a HIV infected patient under antiretroviral therapy including tenofovir therapy who was referred to the Nuclear Medicine Department to complete bone pain study. A bone scan was performed at 3 hours after the injection of 740 MBq of 99mTc-MDP, revealing an abnormal distribution with characteristic changes compatible with osteomalacia. In further analysis, a secondary hyperparathyroidism and osteomalacia were diagnosed in the context of Fanconi syndrome, an infrequent complication described in patients under treatment with tenofovir.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Carlos III, Madrid. mv_torres@hotmail.com
authors.forename: M V
authors.initials: MV
authors.lastname: Torres Isidro
authors.forename: T
authors.initials: T
authors.lastname: García Benayas
authors.forename: M
authors.initials: M
authors.lastname: del Val Gómez Martínez
authors.forename: F
authors.initials: F
authors.lastname: González Gallardo
authors.forename: N
authors.initials: N
authors.lastname: Gambí Pisonero
authors.forename: S
authors.initials: S
authors.lastname: Castilla Miguel
authors.forename: J
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: D
authors.initials: D
authors.lastname: Gallego Sanz
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D003404:Creatinine / Q000097:blood; D005198:Fanconi Syndrome / Q000097:blood / Q000139:chemically induced*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000139:chemically induced / Q000000981:diagnostic imaging*; D061466:Lopinavir; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010018:Osteomalacia / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011744:Pyrimidinones / Q000008:administration & dosage / Q000627:therapeutic use; D011877:Radionuclide Imaging; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D019438:Ritonavir / Q000008:administration & dosage / Q000627:therapeutic use; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D011744:Pyrimidinones; D018894:Reverse Transcriptase Inhibitors; D061466:Lopinavir; D000068698:Tenofovir; D003404:Creatinine; D000469:Alkaline Phosphatase; D000225:Adenine; D019438:Ritonavir