Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields.
Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent (19)F-labelled, (10)B-enriched p-boronophenylalanine-fructose ((19)F-BPA-fr) complex was obtained. (1)H, (19)F, (13)C and (10)B magnetic resonance spectroscopy (MRS) of the (19)F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using (19)F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on (19)F-BPA through (19)F NMR will be feasible.
Porcari
Paola
P
Physics Department, University La Sapienza, Rome, Italy.
Capuani
Silvia
S
Campanella
Renzo
R
La Bella
Angela
A
Migneco
Luisa Maria
LM
Maraviglia
Bruno
B
D000818:Animals; D001895:Boron / Q000627:therapeutic use; D001896:Boron Compounds; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005240:Feasibility Studies; D005632:Fructose / Q000031:analogs & derivatives*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D051381:Rats
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D019275:Radiopharmaceuticals; D005632:Fructose; D001895:Boron