Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.
The nucleoside 5-formyl-2'-deoxyuridine has been used as a starting point for the generation of novel 5-substituted pyrimidine nucleosides that are shown to possess significant antiviral activity against two representative orthopoxviruses, namely vaccinia virus and cowpox virus.
Fan
Xuesen
X
Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
Zhang
Xinying
X
Zhou
Longhu
L
Keith
Kathy A
KA
Kern
Earl R
ER
Torrence
Paul F
PF
D000818:Animals; D001694:Biological Warfare / Q000517:prevention & control*; D015608:Cowpox virus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012899:Smallpox / Q000517:prevention & control*; D014616:Vaccinia virus / Q000187:drug effects*
D011741:Pyrimidine Nucleosides