One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer.
A functional polyrotaxane of a PEI-b-PEG-b-PEI copolymer is synthesized in aqueous solution in a one-pot sequence. To obtain a polyrotaxane with PEG-block-selective inclusion complexes, the solution pH of the polypseudorotaxane is lowered to 4.4 in the presence of 9-anthraldehyde (AN), which triggers the expulsion of the alpha-cyclodextrins (alpha-CDs) from the flank PEI chains. Synthetic strategy of a block-selective polyrotaxane between a PEI-b-PEG-b-PEI copolymer and alpha-cyclodextrins.
Choi
Hak Soo
HS
School of Materials Science and the 21st Century COE Program, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
Ooya
Tooru
T
Yui
Nobuhiko
N
D000873:Anthracenes / Q000494:pharmacology; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D020442:Poloxamer / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry; D047391:alpha-Cyclodextrins / Q000737:chemistry*
D000873:Anthracenes; D003505:Cyclodextrins; D011108:Polymers; D043862:Rotaxanes; D047391:alpha-Cyclodextrins; C475673:polyrotaxane; D014867:Water; D020442:Poloxamer; D011092:Polyethylene Glycols; C073050:9-anthraldehyde; D011094:Polyethyleneimine