Cardioprotection by adiponectin.
Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental studies show that adiponectin plays a protective role in the development of insulin resistance, atherosclerosis, and inflammation. More recent findings have shown that adiponectin directly affects signaling in myocardial cells and exerts beneficial actions on the heart after pressure overload and ischemia-reperfusion injury. This review focuses on the role of adiponectin in the regulation of myocardial remodeling and acute cardiac injury.
Ouchi
Noriyuki
N
Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.
Shibata
Rei
R
Walsh
Kenneth
K
D052242:Adiponectin / Q000172:deficiency / Q000502:physiology*; D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D012307:Risk Factors
D052242:Adiponectin