title: Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes.
abstract: OBJECTIVE
  To determine the minimally modified electronegative LDL (LDL-) and its autoantibodies in coronary syndromes.
  
  
  METHODS
  LDL(-) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL- (microg/mL) and anti-LDL(-) IgG (OD405 nm).
  
  
  RESULTS
  The concentrations of LDL(-) were higher in patients with coronary disease (ACS: 40.7 microg/mL; SA: 35.0 microg/mL) as compared to controls (21.6 microg/mL). The highest LDL- concentrations were found in patients with AMI (41.8 microg/mL). Anti-LDL(-) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL- IgG and CRP levels (r = 0.34, p <0.01) in the studied groups.
  
  
  CONCLUSIONS
  LDL(-) and anti-LDL(-) autoantibodies may be useful markers to follow patients with high risk for coronary events.
authors.affiliation: Centro de Ciências da Saúde, Universidade Estadual de Londrina, Brazil.
authors.forename: Jair A
authors.initials: JA
authors.lastname: Oliveira
authors.forename: Alex
authors.initials: A
authors.lastname: Sevanian
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Rodrigues
authors.forename: Elaine
authors.initials: E
authors.lastname: Apolinário
authors.forename: Dulcineia S P
authors.initials: DS
authors.lastname: Abdalla
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000276:immunology; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology; D011237:Predictive Value of Tests
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D008077:Lipoproteins, LDL