title: Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome.
abstract: OBJECTIVE
  Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA.
  
  
  RESULTS
  Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 microg), followed by continuous infusion (0.15 microg/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level.
  
  
  CONCLUSIONS
  Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. wata2034@mx31.tiki.ne.jp
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Watanabe
authors.forename: Kengo
authors.initials: K
authors.lastname: Fukushima Kusano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Daiji
authors.initials: D
authors.lastname: Miura
authors.forename: Wakako
authors.initials: W
authors.lastname: Sumida
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Banba
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishii
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagase
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Satoru
authors.initials: S
authors.lastname: Sakuragi
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000328:Adult; D053840:Brugada Syndrome / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D000318:Adrenergic beta-Agonists; D002316:Cardiotonic Agents; D007545:Isoproterenol