4,7-Dimethoxy-1,10-phenanthroline: an excellent ligand for the Cu-catalyzed N-arylation of imidazoles.
[reaction: see text] 4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.
Altman
Ryan A
RA
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Buchwald
Stephen L
SL
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000737:chemistry
C518444:4,7-dimethoxy-1,10-phenanthroline; D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; D008024:Ligands; D010618:Phenanthrolines; D003300:Copper; C029899:imidazole