title: Unusual extramedullary recurrences and breast relapse despite hepatic GVHD after allografting in Ph+-ALL.
abstract: Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after BMT. Our report describes a case of an extramedullary recurrence and breast relapse after second-allografting in a female patient with Ph+-acute lymphoblastic leukemia (ALL), occurring when there was active hepatic GHVD. This case illustrates the complex relationship between graft-versus-host disease (GVHD) and graft-versus-leukemia since she had no evidence of leukemia in her marrow demonstrating 100% full-donor chimerism while she had ALL relapse in her breast.
authors.affiliation: Hacettepe University, Division of Hematology, Department of Internal Medicine, Ankara, Turkey. ekoca@hacettepe.edu.tr
authors.forename: Ebru
authors.initials: E
authors.lastname: Koca
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.forename: Gulay S
authors.initials: GS
authors.lastname: Guven
authors.forename: Deniz
authors.initials: D
authors.lastname: Cetiner
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
authors.forename: Aysegul
authors.initials: A
authors.lastname: Uner
authors.forename: Osman I
authors.initials: OI
authors.lastname: Ozcebe
mesh_terms: D001940:Breast / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017254:Leukemic Infiltration / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D011289:Preleukemia / Q000628:therapy; D012074:Remission Induction