title: Diversity of 26-locus Y-STR haplotypes in a Nepalese population sample: isolation and drift in the Himalayas.
abstract: Twenty-six Y-chromosomal short tandem repeat (STR) loci were amplified in a sample of 769 unrelated males from Nepal, using two multiplex polymerase chain reaction (PCR) assays. The 26 loci gave a discriminating power of 0.997, with 59% unique haplotypes, and the highest frequency haplotype occurring 12 times. We identified novel alleles at four loci, microvariants at a further two, and nine examples of amelogenin-Y deletions (1.2%). Comparison with a similarly sized Bhutanese sample typed with the same markers suggested histories of isolation and drift, with drift having a greater effect in Bhutan. Extended (11-locus) haplotypes for the Nepalese samples have been submitted to the Y-STR Haplotype Reference Database (YHRD).
authors.affiliation: Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Parkin
authors.forename: Thirsa
authors.initials: T
authors.lastname: Kraayenbrink
authors.forename: Jean Robert M L
authors.initials: JR
authors.lastname: Opgenort
authors.forename: George L
authors.initials: GL
authors.lastname: van Driem
authors.forename: Nirmal Man
authors.initials: NM
authors.lastname: Tuladhar
authors.forename: Peter
authors.initials: P
authors.lastname: de Knijff
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jobling
mesh_terms: D053523:Amelogenin / Q000235:genetics; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D009390:Nepal; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences
chemical_list: D053523:Amelogenin