title: Clinical advancement of EGFR inhibitors in cancer therapy.
abstract: The epidermal growth factor receptor (EGFR) represents one of the most promising molecular targets in cancer therapeutics. An array of EGFR inhibitory drugs have been developed that are progressing rapidly in oncology clinical trials. This chapter provides an overview of EGFR inhibitors and key clinical trial results that are helping to define a future role for these molecular agents in cancer treatment.
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, USA.
authors.forename: Prakash
authors.initials: P
authors.lastname: Chinnaiyan
authors.forename: Paul M
authors.initials: PM
authors.lastname: Harari
mesh_terms: D002986:Clinical Trials as Topic; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D066246:ErbB Receptors