B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas.
The very recent discovery of B-RAF point mutations as the most prevalent genetic alteration in papillary thyroid carcinoma has revolutionized the molecular knowledge of thyroid malignancies. In this review, we address the role played by such mutations in the etiopathogenesis, diagnosis, prognosis, and therapy selection of thyroid cancer, with an emphasis on papillary carcinoma.
Trovisco
Vítor
V
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, 4200 Porto, Portugal.
Soares
Paula
P
Sobrinho-Simões
Manuel
M
D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D017354:Point Mutation; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics*
C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf