No evidence for oxidative stress in patients on home parenteral nutrition.
OBJECTIVE
Patients on total parenteral nutrition depend on the composition of the nutritional formulation for maintenance of their oxidant-antioxidant balance. The present observational study was conducted to evaluate a substantial part of our patient population for evidence of oxidative stress.


METHODS
Venous blood samples were obtained from 41 patients on home parenteral nutrition (HPN) and 41 healthy controls. Glutathione in plasma and whole blood, glutathione peroxidase and superoxide dismutase in erythrocytes and total plasma antioxidant capacity were measured to assess the antioxidant status. Oxidant status was evaluated by measuring the production of reactive oxygen species by leukocytes. Oxidative damage was assessed by measuring lipid peroxidation and protein oxidation products.


RESULTS
Patients on HPN showed some signs of increased oxidative stress, however, there were no signs for oxidative damage, compared with healthy controls. In addition, activity of any underlying disease was not associated with increased oxidative stress.


CONCLUSIONS
The current treatment regime for patients on HPN at our center apparently prevents the development of significant oxidative damage, despite signs of some oxidative stress. Based on these data, adaptations in the composition of parenteral nutritional formulations do not seem mandatory.
Schepens
Marloes A A
MA
Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Roelofs
Hennie M J
HM
Peters
Wilbert H M
WH
Wanten
Geert J A
GJ
D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D016331:Parenteral Nutrition, Home / Q000009:adverse effects / Q000379:methods; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014815:Vitamins / Q000097:blood
D000975:Antioxidants; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione