title: Exact simulation of integrate-and-fire models with synaptic conductances.
abstract: Computational neuroscience relies heavily on the simulation of large networks of neuron models. There are essentially two simulation strategies: (1) using an approximation method (e.g., Runge-Kutta) with spike times binned to the time step and (2) calculating spike times exactly in an event-driven fashion. In large networks, the computation time of the best algorithm for either strategy scales linearly with the number of synapses, but each strategy has its own assets and constraints: approximation methods can be applied to any model but are inexact; exact simulation avoids numerical artifacts but is limited to simple models. Previous work has focused on improving the accuracy of approximation methods. In this article, we extend the range of models that can be simulated exactly to a more realistic model: an integrate-and-fire model with exponential synaptic conductances.
authors.affiliation: Département d'Informatique, Equipe Odyssée, Ecole Normale Supérieure, 75230 Paris Cedex 05, France. brette@di.ens.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Brette
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D007473:Ion Channels