title: Cardiopulmonary impairment in young women with polycystic ovary syndrome.
abstract: BACKGROUND
  Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO(2max)). At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed.
  
  
  OBJECTIVE
  Our objective was to assess cardiopulmonary functional capacity in young PCOS overweight patients.
  
  
  METHODS
  We conducted a prospective baseline-controlled clinical study at University Federico II of Naples, School of Medicine (Naples, Italy).
  
  
  METHODS
  Forty-five PCOS patients were matched with 45 healthy women for age (mean +/- sd, 21.3 +/- 2.0 vs. 21.6 +/- 1.9 yr, respectively) and body mass index (29.4 +/- 3.6 vs. 29.0 +/- 3.4 kg/m(2), respectively).
  
  
  METHODS
  We assessed hormonal and metabolic pattern and functional capacity by cardiopulmonary exercise testing to evaluate maximal oxygen consumption (VO(2max)), oxygen consumption at anaerobic threshold (VO(2AT)), and the maximal workload at peak exercise.
  
  
  RESULTS
  VO(2max) (17.0 +/- 3.7 vs. 26.8 +/- 3.5 ml/kg.min), oxygen consumption at anaerobic threshold (13.9 +/- 3.0 vs. 21.2 +/- 3.8 ml/kg.min), and maximal workload at peak exercise (101.3 +/- 25.2 vs. 135 +/- 22.6 W) were significantly (P < 0.001) reduced in PCOS subjects compared with healthy women. The multiple linear regression analysis showed that only homeostasis model assessment appears to have a strong negative linear relation with VO(2max) in PCOS. No relation was found in controls.
  
  
  CONCLUSIONS
  Our data demonstrate a reduced cardiopulmonary functional capacity in young PCOS patients.
authors.affiliation: Department of Molecular, Clinical Endocrinology, and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. francescoorio@virgilio.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Teresa
authors.initials: T
authors.lastname: Cascella
authors.forename: Francesco
authors.initials: F
authors.lastname: Manguso
authors.forename: Laura
authors.initials: L
authors.lastname: Vuolo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Russo
authors.forename: Achille
authors.initials: A
authors.lastname: Tolino
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005080:Exercise Test; D005215:Fasting; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D010101:Oxygen Consumption; D005082:Physical Exertion; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein