title: [Design, synthesis and insulin-sensitizing activity of indole derivatives].
abstract: OBJECTIVE
  To design and synthesize compounds with insulin-sensitizing activity.
  
  
  METHODS
  Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.
  
  
  RESULTS
  One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.
  
  
  CONCLUSIONS
  This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
authors.affiliation: School of Pharmacy, Guiyang Medical College, China. tlei1974@hotmail.com
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.forename: Yu-she
authors.initials: YS
authors.lastname: Yang
authors.forename: Ru-yun
authors.initials: RY
authors.lastname: Ji
mesh_terms: D041721:3T3-L1 Cells / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D014280:Triglycerides / Q000378:metabolism
chemical_list: D007004:Hypoglycemic Agents; D007211:Indoles; D007328:Insulin; D014280:Triglycerides