title: Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia.
abstract: Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
authors.affiliation: Department of Genetics, Autonoma University of Madrid, Edificio de Biología, Facultad de Ciencias, Calle Darwin, 2. 28049, Cantoblanco, Madrid, Spain.
authors.forename: Concepcion
authors.initials: C
authors.lastname: Vaquero Lorenzo
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-Garcia
authors.forename: Montserrat
authors.initials: M
authors.lastname: Diaz-Hernandez
authors.forename: Carlota
authors.initials: C
authors.lastname: Botillo-Martin
authors.forename: M Mercedes
authors.initials: MM
authors.lastname: Perez-Rodriguez
authors.forename: Carolina
authors.initials: C
authors.lastname: Fernandez-Ramos
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Saiz-Gonzalez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Quintero-Gutierrez
authors.forename: Jeronimo
authors.initials: J
authors.lastname: Saiz-Ruiz
authors.forename: Jose
authors.initials: J
authors.lastname: Fernandez Piqueras
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Gonzalez de Rivera
authors.forename: Jose
authors.initials: J
authors.lastname: de Leon
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D013030:Spain / Q000453:epidemiology
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D004247:DNA