[Sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome].
OBJECTIVE
To observe the changes of sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome (ARDS).


METHODS
After isolation of the AT II cells as ARDS model induced by oleic acid, the whole cell sodium current was recorded in 5 h with patch-clamp in whole-cell mode. The effect of beta2-agonist terbutaline on the current was also examined.


RESULTS
The sodium currents recorded from AT II cells in ARDS were smaller than that of the control cells, but the current could be stimulated to increase obviously by terbutaline.


CONCLUSIONS
AT II cells can actively transport sodium ion even under conditions of ARDS, but this capacity can not match that of the control cells. Terbutaline can obviously stimulate the sodium current.
Li
Tao-ping
TP
Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Shen
Hai-yan
HY
D000208:Acute Disease; D000818:Animals; D017136:Ion Transport; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008564:Membrane Potentials; D019301:Oleic Acid; D018408:Patch-Clamp Techniques; D011650:Pulmonary Alveoli / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000502:physiology; D013577:Syndrome
D015222:Sodium Channels; D019301:Oleic Acid; D012964:Sodium