Challenges in the diagnosis of post kala-azar dermal leishmaniasis.
Post kala-azar dermal leishmaniasis (PKDL) is a dermatosis that occurs as a sequel of visceral leishmaniasis (VL). Elimination of VL requires detection and treatment of PKDL, necessarily because of its capacity to serve as a reservoir for the causative parasite, Leishmania donovani. Diagnosis of PKDL presents a challenge due to low parasite burden in the lesions. In this article we have reviewed the recent advances in the development of immunological and molecular methods for diagnosis of PKDL.
Salotra
Poonam
P
Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India. salotra@vsnl.com
Singh
Ruchi
R
D000372:Agglutination Tests; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D019066:Facies; D006801:Humans; D007194:India; D016773:Leishmaniasis, Cutaneous / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000469:parasitology; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000469:parasitology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D000953:Antigens, Protozoan