title: Locoregional pain treatment. Troubles and prospectives: antalgic radiotherapy.
abstract: Pain control in patients with cancer represents a significant aspect of radiation therapy practice. Radiation therapy is one of the most effective, and often the only, therapeutic option to relieve pain caused by nerve compression or infiltration by malignant tumor, pain from liver and bony metastases and it provides also successful palliation of dysphagia caused by oesophageal carcinoma and of pain due to pancreatic cancer. Various instruments are avaliable for pain evaluation but a valid methodology to assess the pain status in the patient with cronic cancer pain is still an important clinical problem. In this complex and wide scene this contribution wants to confirm the role of radiotherapy in cancer pain control, in paricular in bone metastases, and to involve the patient himself in the survey of radiation treatement response by a subjective evaluation of bone pain, elaborating a reliable and valid unidimensional method by which recording the self-rating of the patient's sensation. Materials and Methods For the subjective evaluation of pain caused by bone metastases we used an application form with which drawing information in the course of time in terms of: response to the treatment, duration of symptom relief and quality of life. Results Considering as cut-off a dose of 30 Gy, which is commonly considered the conventional treatment for bone metastases, the partial and complete response were, respectively, of 54% and 30% in the patients treated with dose higher than or equal to 30 Gy, and 60% and 20% in the ones treated with doses lower than 30 Gy. In the whole, in 84 patients, the global response was of 82%, in accordance with literature. Conclusion In this retrospective study, the analysis of patient's subjective experience confirmed the effectiveness of radiotherapy in reducing pain caused by bone metastases and in improving quality of life of the patient himself. Given the conflicting opinions on low-dose short-course radiotherapy versus prolonged or higher dose schedules on initial pain relief, we are going to define categories of homogenous patients on whom starting treatment schedules with the aim or of palliation of the symptom or of the functional restitutio, on the base of the expectation and the quality of life.
authors.affiliation: Department of Radiotherapy, Institute of Radiology, Università Cattolica del Sacro Cuore, Policlinico Universitario A. Gemelli, Centro di Ricerca e Formazione ad Alta Tecnologia nelle Scienze Biomediche, Rome, Italy. gmantini@rm.unicatt.it
authors.forename: G
authors.initials: G
authors.lastname: Mantini
authors.forename: M
authors.initials: M
authors.lastname: Campitelli
authors.forename: M
authors.initials: M
authors.lastname: Balducci
authors.forename: S
authors.initials: S
authors.lastname: Manfrida
authors.forename: V
authors.initials: V
authors.lastname: Valentini
authors.forename: A
authors.initials: A
authors.lastname: Turriziani
authors.forename: A G
authors.initials: AG
authors.lastname: Morganti
authors.forename: A
authors.initials: A
authors.lastname: Scopa
authors.forename: N
authors.initials: N
authors.lastname: Cellini
mesh_terms: D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000209:etiology / Q000532:radiotherapy*; D010147:Pain Measurement; D011788:Quality of Life; D011878:Radiotherapy / Q000379:methods; D012189:Retrospective Studies