title: Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes.
abstract: Platinum (IV) complexes [Pt (L)2Cl2] [where, L= benzyl-N-thiohydrazide (L1), (benzyl-N-thio)-1,3-propanediamine (L2), benzaldehyde-benzyl-N-thiohydrazone (L3) and salicylaldehyde-benzyl-N-thiohydrazone (L4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands were found to act in monobasic bidentate fashion. Analytical data reveal that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic studies have been carried out for some complexes. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (Ea), apparent activation entropy (S#) and heat of reaction (DeltaH) have also been carried out for some complexes.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. ajaykmishra1@yahoo.com
authors.forename: A K
authors.initials: AK
authors.lastname: Mishra
authors.forename: S B
authors.initials: SB
authors.lastname: Mishra
authors.forename: N
authors.initials: N
authors.lastname: Manav
authors.forename: D
authors.initials: D
authors.lastname: Saluja
authors.forename: R
authors.initials: R
authors.lastname: Chandra
authors.forename: N K
authors.initials: NK
authors.lastname: Kaushik
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D009944:Organoplatinum Compounds