title: Progesterone receptor antagonist is effective in relieving neuropathic pain.
abstract: Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects. Co-administration of estrogen did not reduce but tended to enhance the antinociceptive effect of ICI 182,780. On the other hand, co-administration of progesterone dose-dependently reduced the antinociceptive effect of ICI 182,780, indicating that the antinociceptive effect is through antiprogesterone receptor activity of ICI 182,780. These results suggest that spinal progesterone receptors play an important role in neuropathic pain, and that controlling the activity of progesterone receptors may be of great importance in the treatment of neuropathic pain.
authors.affiliation: Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kondo
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Yabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurihara
authors.forename: Hironao
authors.initials: H
authors.lastname: Saegusa
authors.forename: Shuqin
authors.initials: S
authors.lastname: Zong
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tanabe
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology; D000077267:Fulvestrant; D006358:Hot Temperature / Q000009:adverse effects; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009437:Neuralgia / Q000503:physiopathology / Q000517:prevention & control*; D010146:Pain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D010147:Pain Measurement / Q000379:methods; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors* / Q000502:physiology; D013127:Spinal Nerves / Q000293:injuries / Q000503:physiopathology
chemical_list: D000700:Analgesics; D004965:Estrogen Antagonists; D004967:Estrogens; D011980:Receptors, Progesterone; D000077267:Fulvestrant; D011374:Progesterone; D004958:Estradiol