Parathyroid carcinoma: A rare case with mandibular brown tumor.
Parathyroid carcinoma constitutes less than 1 % of primary hyperparathyroidism. The male to female ratio is approximately equal and the mean age at presentation is 40 years. In about half of the patients there is a palpable cervical mass, and serum calcium level is usually above 14 mg/dl. In a case report we present a 21-year-old man with a non-tender, non-mobile bulging mandibular mass. He suffered from fatigue, recent weight loss, hoarseness, polydipsia, polyuria, hematuria, recurrent renal stones and bouts of constipation and diarrhea. A mandibular biopsy confirmed brown tumor. Serum calcium level was 15.4 mg/dl. Cervical ultrasound revealed a hypoecho area suspicious of parathyroid adenoma. Parathyroid carcinoma was later confirmed and en bloc resection was performed. During a two-year follow up there has been no evidence of recurrence or hypercalcemia. This unique case of parathyroid carcinoma in conjunction with brown tumor is the second reported case worldwide.
Pahlavan
Payam S
PS
Department of Physiology and Pathophysiology, University of Heidelberg, Germany. P.Samareh_Pahlavan@med.uni-heidelberg.de
Severin
Marianne C
MC
D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery*; D000328:Adult; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery*; D010173:Palpation; D010282:Parathyroid Neoplasms / Q000175:diagnosis / Q000601:surgery*; D035583:Rare Diseases / Q000175:diagnosis / Q000601:surgery