title: Effect of arachnoid plasty using fibrin glue membrane after clipping of ruptured aneurysm on the occurrence of complications and outcome in the elderly patients.
abstract: BACKGROUND
  In elderly patients with aneurysmal subarachnoid hemorrhage (SAH), complications including vasosopasm, subdural effusion, and late hydrocephalus, are liable to occur even after aneurysmal surgery. We examined prospectively the efficacy of arachnoid plasty using fibrin glue membrane during surgery of ruptured aneurysms in the elderly patients for preventing complications. The effects on the modified Rankin scale (mRS) and the Glasgow outcome scale (GOS) 3 months after SAH were noted.
  
  
  METHODS
  Total of 31 patients aged more than 70 years selected from a consecutive series of patients with aneurysmal SAH, were divided into two groups alternately, a group with arachnoid plasty (n = 16) and a control group without arachnoid plasty (n = 15). Statistical analyses were performed to assess relationships among various clinical and neuroradiological variables, especially between arachnoid plasty and occurrence of symptomatic vasospasm, subdural effusion, late hydrocephalus, or outcome such as mRS and GOS 3 months after onset.
  
  
  RESULTS
  Statistical analyses revealed that arachnoid plasty were associated with late hydrocephalus and subdural effusion negatively, but with better mRS at 3 months after SAH. A tendency to be associated with less frequent symptomatic vasospasm was also noted.
  
  
  CONCLUSIONS
  Arachnoid plasty using fibrin glue is suggested to be effective in preventing complications associated with SAH and aneurysmal surgery. A better outcome in the elderly patients can be achieved.
authors.affiliation: Department of Neurosurgery, School of Medicine, Toyama University, Toyama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mino
authors.forename: Y
authors.initials: Y
authors.lastname: Hirashima
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Masuoka
authors.forename: K
authors.initials: K
authors.lastname: Yamatani
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: R
authors.initials: R
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Nogami
authors.forename: S
authors.initials: S
authors.lastname: Endo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001099:Arachnoid / Q000293:injuries / Q000503:physiopathology / Q000601:surgery*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D002532:Intracranial Aneurysm / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008567:Membranes, Artificial; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods / Q000639:trends; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology / Q000601:surgery*; D013346:Subarachnoid Space / Q000503:physiopathology / Q000601:surgery; D013353:Subdural Effusion / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D013525:Surgical Instruments / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D008567:Membranes, Artificial