title: [Thyroid hormones and the cardiomyocytes].
abstract: The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.
authors.affiliation: The Second Department of Internal Medicine with Subdepartment of Endocrinology and Diabetology, Voivodeship Specialistic Hospital No. 3, Rybnik.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Gatnar
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Dorota
authors.initials: D
authors.lastname: Pakuła
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
authors.forename: Halina
authors.initials: H
authors.lastname: Borgiel-Marek
authors.forename: Roman
authors.initials: R
authors.lastname: Gnot
authors.forename: Piotr
authors.initials: P
authors.lastname: Pakuła
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pawłowska
mesh_terms: D000818:Animals; D006980:Hyperthyroidism / Q000503:physiopathology*; D007037:Hypothyroidism / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000096:biosynthesis; D013963:Thyroid Hormones / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood / Q000494:pharmacology
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D018995:Myosin Heavy Chains