title: Skin involvement in Hodgkin's disease.
abstract: Hodgkin's disease involving the skin is an unusual occurrence and is found in 0.5-3.4 percent of these patients. The most common clinical presentation is of single or multiple dermal or subcutaneous nodules. The mechanisms usually implicated include direct extension from an underlying nodal focus, hematogenous dissemination, and, most often, retrograde lymphatic spread, distal to involved lymph nodes. We report the case of a patient with refractory Hodgkin's disease who presented with skin involvement.
authors.affiliation: Haematology Section, 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Perifanis
authors.forename: Georgios
authors.initials: G
authors.lastname: Sfikas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tziomalos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Sotiriadis
authors.forename: Vassilia
authors.initials: V
authors.lastname: Garipidou
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008942:Mitoxantrone / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone; D014740:Vidarabine; D002945:Cisplatin