Synthesis of spiro-pyridopyridine analogues by Grubbs' catalyst mediated alkene and enyne metathesis reaction.
A practical synthesis of spiro-naphthyridinone derivatives is described by the combination of the Claisen rearrangement and ring-closing metathesis/ring-closing enyne metathesis process. The RCM or RCEM proceeded smoothly in the presence of Grubbs' first generation catalyst at room temperature under a nitrogen atmosphere.
Majumdar
K C
KC
Department of Chemistry, University of Kalyani, West Bengal, India. kcm_ku@yahoo.co.in
Islam
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Rahaman
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Roy
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