Secondary transmission of varicella vaccine virus in a chronic care facility for children.
A 16-year-old varicella-seronegative resident at a chronic care facility received varicella vaccine; 15 days later he developed severe varicella. Subsequently, a 13-year-old resident and a 39-year-old health care worker developed mild varicella. We demonstrate that vaccine-strain virus was transmitted to both persons, and that transmission included at least 2 variant vaccine strains.
Grossberg
Richard
R
Hattie Larlham Center for Children With Disabilities, Mantua, Ohio, USA.
Harpaz
Rafael
R
Rubtcova
Elena
E
Loparev
Vladimir
V
Seward
Jane F
JF
Schmid
D Scott
DS
D000293:Adolescent; D000328:Adult; D002644:Chickenpox / Q000235:genetics / Q000635:transmission*; D019433:Chickenpox Vaccine / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D003428:Cross Infection / Q000635:transmission* / Q000821:virology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D017758:Infectious Disease Transmission, Patient-to-Professional; D008297:Male; D017354:Point Mutation; D012112:Residential Facilities
D019433:Chickenpox Vaccine