Asymmetric oscillation of adherent targeted ultrasound contrast agents.
With a lipid shell containing biotin, micron-sized bubbles bound to avidin on a porous and flexible cellulose boundary were insonified by ultrasound. The oscillation of these targeted microbubbles was observed by high-speed photography and compared to the oscillation of free-floating microbubbles. Adherent microbubbles were observed to oscillate asymmetrically in the plane normal to the boundary, and nearly symmetrically in the plane parallel to the boundary, with a significantly smaller maximum expansion in each dimension for bound than free bubbles. With sufficient transmitted pressure, a jet was produced traveling toward the boundary.
Zhao
Shukui
S
Department of Biomedical Engineering, University of California, Davis, California 95616.
Ferrara
Katherine W
KW
Dayton
Paul A
PA