title: [Effects of prenatal alcohol exposure on auditory brainstem response in rats].
abstract: OBJECTIVE
  To study the effects of prenatal alcohol exposure, with an animal model of auditory brainstem response recorded in the conditions of various alcohol dosages administrated during embryonic period, on auditory nervous system in rats.
  
  
  METHODS
  Normal female rats were divided into 2 groups. From the days 8.5 after mating, pregnant rats were fed 50% analytical reagent alcohol via intragastric administration with 2.0 and 1.0 g/(kg x d) respectively in consecutive 6 days. On the days 40 after birth, ABR was recorded in young rats under anesthesia. Normal young rats with parallel age were chosen as the normal group.
  
  
  RESULTS
  Prenatal alcohol exposure had effects on ABR, manifesting the incidence rate of I wave lowing (14%, 30%), latency delaying (P<0.05) and amplitude reducing.
  
  
  CONCLUSIONS
  Prenatal alcohol exposure had conspicuous effects on auditory nervous system in rats, by step down nerve impulse conduction.
authors.affiliation: Department of Otorhinolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000503:physiopathology*; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley