Successful use of combination antifungal therapy in the treatment of coccidioides meningitis.
Coccidioidal meningitis is a highly lethal condition with a high morbidity and relapse rate caused by Coccidioides immitis. This case report highlights the difficulty in diagnosing and treating coccidioidal meningitis, and discusses a novel combination antifungal therapy (voriconazole and liposomal amphotericin B), which was used to treat this patient.
Antony
Suresh J
SJ
Texas Tech University Health Sciences Center, El Paso, USA. santony@elp.rr.com
Jurczyk
Peter
P
Brumble
Lisa
L
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects / Q000302:isolation & purification; D003047:Coccidioidomycosis / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis / Q000188:drug therapy*; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole