title: Hospital-based active surveillance of childhood pertussis in Austria from 1996 to 2003: estimates of incidence and vaccine effectiveness of whole-cell and acellular vaccine.
abstract: BACKGROUND
  This study was undertaken to analyse the epidemiology of pertussis disease among hospitalised children during the transition period from whole-cell to acellular pertussis vaccine in order to compare the respective estimates of vaccine effectiveness.
  
  
  METHODS
  Surveillance was conducted between 1 January 1996 and 31 December 2003. The data originated from a voluntary hospital-based surveillance network including all 44 nationwide paediatric departments.
  
  
  RESULTS
  The mean annual hospitalisation incidence for children decreased over time, from 27.9 per 100,000 population in 1996 to 6.8 cases per 100,000 population in 2003. The mean age of reported hospitalised pertussis cases was 4.7 years (+/- 5.5 S.D.), increasing from 4.06 years (+/- 4.6 S.D.) in 1996 to 5.5 years (+/- 8.6 S.D.) in 2003. Estimated vaccine effectiveness (after three vaccine doses) was 79% for the whole-cell versus 92% for the acellular pertussis vaccine. A significantly higher proportion (19%) of fully immunised children among hospitalised patients was observed for the years where only acellular pertussis vaccine was used compared to whole-cell vaccine era (2%) which was, however, mainly due to children above 2 years of age.
  
  
  CONCLUSIONS
  Our results imply that despite high vaccination coverage rate, pertussis is still a considerable cause of hospital admissions in children in Austria where it remains to be shown that the novel vaccination strategy of additional booster doses in adolescents and adults will control disease in the long term.
authors.affiliation: Department of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria. pamela.rendi-wagner@meduniwien.ac.at
authors.forename: Pamela
authors.initials: P
authors.lastname: Rendi-Wagner
authors.forename: Michael
authors.initials: M
authors.lastname: Kundi
authors.forename: Andrea
authors.initials: A
authors.lastname: Mikolasek
authors.forename: Andreas
authors.initials: A
authors.lastname: Vécsei
authors.forename: Martin
authors.initials: M
authors.lastname: Frühwirth
authors.forename: Herwig
authors.initials: H
authors.lastname: Kollaritsch
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001317:Austria / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006760:Hospitalization; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D010567:Pertussis Vaccine; D011159:Population Surveillance; D013223:Statistics as Topic; D022282:Vaccines, Acellular; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine; D022282:Vaccines, Acellular