title: The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study.
abstract: BACKGROUND
  Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region.
  
  
  METHODS
  In a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III.
  
  
  RESULTS
  A thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (P=0.27, OR 1.5, 95%CI 1.0-2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (P>0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (P>0.05).
  
  
  CONCLUSIONS
  There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia.
authors.affiliation: Dicle University School of Medicine, Department of Obstetrics and Gynecology, Diyarbakir, Turkey. ayalinkaya@dicle.edu.tr
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yalinkaya
authors.forename: Mahmut
authors.initials: M
authors.lastname: Erdemoglu
authors.forename: Nurten
authors.initials: N
authors.lastname: Akdeniz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kale
authors.forename: Ebru
authors.initials: E
authors.lastname: Kale
mesh_terms: D000990:Antithrombin III / Q000032:analysis / Q000235:genetics; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D009154:Mutation / Q000235:genetics; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D020151:Protein C Deficiency / Q000097:blood / Q000235:genetics; D018455:Protein S Deficiency / Q000097:blood / Q000235:genetics; D011516:Prothrombin / Q000032:analysis / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)