title: Controlled release from a nanocarrier entrapped within a microcarrier.
abstract: This study illustrates the entrapment of the dye molecule fluorescein sodium salt (FSS) by hydrogel nanoparticles, which are in turn confined inside a water-in-oil-in-water double-emulsion globule, and its subsequent release by the action of the competing agent hydrochloric acid (HCl). Thus, a "double carrier" concept is being introduced in which a nanoscale delivery vehicle is being transported by a microscale delivery vehicle in order to simultaneously take advantage of both systems. This may facilitate storage and handling while protecting the active substance and improving its action upon application.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, USA.
authors.forename: Edith C
authors.initials: EC
authors.lastname: Rojas
authors.forename: Nurettin
authors.initials: N
authors.lastname: Sahiner
authors.forename: Louise B
authors.initials: LB
authors.lastname: Lawson
authors.forename: Vijay T
authors.initials: VT
authors.lastname: John
authors.forename: Kyriakos D
authors.initials: KD
authors.lastname: Papadopoulos
mesh_terms: D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004655:Emulsions; D019793:Fluorescein / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008832:Microchemistry; D008962:Models, Theoretical; D015394:Molecular Structure; D053758:Nanoparticles
chemical_list: D003692:Delayed-Action Preparations; D004655:Emulsions; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019793:Fluorescein