title: Cellular toxicity of carbon-based nanomaterials.
abstract: The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro on lung tumor cells. Our work clearly indicated that these materials are toxic while the hazardous effect is size-dependent. Moreover, cytotoxicity is enhanced when the surface of the particles is functionalized after an acid treatment.
authors.affiliation: Institut de Physique de la Matière Complexe (IPMC), Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. arnaud.magrez@epfl.ch
authors.forename: Arnaud
authors.initials: A
authors.lastname: Magrez
authors.forename: Sandor
authors.initials: S
authors.lastname: Kasas
authors.forename: Valérie
authors.initials: V
authors.lastname: Salicio
authors.forename: Nathalie
authors.initials: N
authors.lastname: Pasquier
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Seo
authors.forename: Marco
authors.initials: M
authors.lastname: Celio
authors.forename: Stefan
authors.initials: S
authors.lastname: Catsicas
authors.forename: Beat
authors.initials: B
authors.lastname: Schwaller
authors.forename: Laszló
authors.initials: L
authors.lastname: Forró
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D013499:Surface Properties
chemical_list: D037742:Nanotubes, Carbon