title: Increased neuronal expression of alpha B-crystallin in human olivary hypertrophy.
abstract: We studied morphologic changes in olivary hypertrophy from dentato-olivary tract lesions by immunohistologic methods with antialpha B-crystallin and antiheat shock protein 27 (HSP 27). The majority of central chromatolysis-like enlarged neurons, which are frequently seen in the early stages of olivary hypertrophy on ipsilateral lesions, showed a marked expression of alpha B-crystallin; however, HSP 27 did not show increased expression in those neurons. In the later stages of olivary hypertrophy, increased expressions of alpha B-crystallin varied in the remaining neurons and the expression of HSP 27 increased in hypertrophied astrocytes, although the expression of alpha B-crystallin in hypertrophic astrocytes was not prominent. The accumulation of alpha B-crystallin and HSP 27 may represent responses to pathologic conditions.
authors.affiliation: Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Fukushima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Takatama
authors.forename: Koichi
authors.initials: K
authors.lastname: Okamoto
mesh_terms: D000368:Aged; D001253:Astrocytes / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D009836:Oligodendroglia / Q000378:metabolism; D009847:Olivary Nucleus / Q000378:metabolism* / Q000473:pathology*; D038203:alpha-Crystallin B Chain / Q000096:biosynthesis*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D038203:alpha-Crystallin B Chain