Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents.
An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.
Choi
Sun
S
College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Jung
Keumnyeo
K
Ryu
Jaesang
J
D042462:4-Quinolones / Q000138:chemical synthesis*; D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D050257:Tubulin Modulators / Q000138:chemical synthesis*
D042462:4-Quinolones; D000970:Antineoplastic Agents; D050257:Tubulin Modulators