title: [Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?].
abstract: BACKGROUND
  The goal of our study was to evaluate the morphine-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) following both conventional and laparoscopic colon surgery.
  
  
  METHODS
  In this prospective, randomized clinical trial, 180 patients were assigned to three groups. Two groups received either paracetamol or parecoxib/valdecoxib in addition to piritramid via patient-controlled or nurse-controlled analgesia pump. Patients in the control group received piritramid only. The total piritramid consumption during hospital stay was recorded.
  
  
  RESULTS
  Total opioid consumption was significantly lower in the two groups who received NSAIDs. Comparing conventional and laparoscopic surgery, the latter group had much lower opioid consumption.
  
  
  CONCLUSIONS
  The use of NSAIDs following colon surgery significantly reduces postoperative opioid consumption.
authors.affiliation: Abteilung für Allgemein- und Visceralchirurgie, Marienhospital, Böheimstrasse 37, 70199 Stuttgart. barbarakraft@vinzenz.de
authors.forename: B
authors.initials: B
authors.lastname: Kraft
authors.forename: S
authors.initials: S
authors.lastname: Leroy
authors.forename: M
authors.initials: M
authors.lastname: Schweizer
authors.forename: W
authors.initials: W
authors.lastname: Junginger
authors.forename: R
authors.initials: R
authors.lastname: Bittner
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000009:adverse effects; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D003108:Colonic Diseases / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007555:Isoxazoles / Q000008:administration & dosage* / Q000009:adverse effects; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010892:Pirinitramide / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D012002:Rectal Diseases / Q000601:surgery*; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D000096926:Benzenesulfonamides
chemical_list: D000082:Acetaminophen; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D010892:Pirinitramide; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides; C409945:parecoxib