Acute and long-term effects of alkaloid extract of Mitragyna speciosa on food and water intake and body weight in rats.
Acute administration of Mitragyna speciosa (MS) extract (45 and 50 mg/kg) significantly resulted in dose-dependent decreases in food and water intakes (P<0.05) in rats. Prolonged suppressing effects were observed following administration of the MS extract (40 mg/kg) for 60 consecutive days. Moreover, the long-term administration also significantly suppressed weight gaining.
Kumarnsit
Ekkasit
E
Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand. ekkasit.k@psu.ac.th
Keawpradub
Niwat
N
Nuankaew
Watcharin
W
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D008297:Male; D032065:Mitragyna; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D001067:Appetite Depressants; D010936:Plant Extracts