Cerebral perfusion changes during cataplexy in narcolepsy patients.
To localize cerebral perfusion differences during cataplexy, brain SPECT subtraction was performed between cataplexy and baseline awake period or REM sleep in patients with narcolepsy. During cataplexy, subtracted SPECT showed hyperperfusion in right amygdala, bilateral cingulate gyri, basal ganglia, thalami, premotor cortices, sensorimotor cortices, right insula, and brainstem, and hypoperfusion in prefrontal cortex and occipital lobe. This result suggests that cataplexy is produced by the activation of amygdalo-cortico-basal ganglia-brainstem circuit.
Hong
Seung Bong
SB
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea. sbhong@smc.samsung.co.kr
Tae
Woo Suk
WS
Joo
Eun Yeon
EY
D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002385:Cataplexy / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011877:Radionuclide Imaging