Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.
Oxidative stress is believed to contribute to neurodegeneration following ischemic injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of curcumin (Cur) on neuronal death of hippocampal CA1 neurons following transient forebrain ischemia in rat. Treatment of Cur (200 mg/kg/day, i.p.) at three different times (immediately, 3 h and 24 h after ischemia) significantly (P<0.01) reduced neuronal damage 7 days after ischemia. Also, treatment of ischemic rats with Cur decreased the elevated levels of MDA and increased GSH contents, catalase and SOD activities to normal levels. In the in vitro, Cur was as potent as antioxidant (IC(50) = 1 microM) as butylated hydroxytoluene. The present study demonstrates that curcumin treatment attenuates forebrain ischemia-induced neuronal injury and oxidative stress in hippocampal tissue. Thus treatment with curcumin immediately or even delayed until 24 h may have the potential to be used as a protective agent in forebrain ischemic insult in human.
Al-Omar
Fadhel A
FA
Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, 11451 Riyadh, Kingdom of Saudi Arabia.
Nagi
Mahmoud N
MN
Abdulgadir
Mustafa M
MM
Al Joni
Khalda S
KS
Al-Majed
Abdulhakeem A
AA
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D002545:Brain Ischemia / Q000473:pathology*; D002374:Catalase / Q000378:metabolism; D003474:Curcumin / Q000378:metabolism* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000378:metabolism* / Q000627:therapeutic use; D018384:Oxidative Stress; D016548:Prosencephalon / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D003474:Curcumin