[Cytological aspects of therapeutic pathomorphism of lung squamous cell carcinoma during intratumor chemotherapy].
The paper shows the rate of pathomorphism, by comparing the major cytometrical indices of squamous-cell cancer of the lung before and after single-stage intratumoral chemotherapy on the basis of studies of puncture and intraoperative specimens from 13 patients. Morphometry of 1950 relatively preserved tumor cells was made. The degree of intratumor chemotherapeutic action on tumor cells was objectively reflected in a significant difference in the mean values of the area of the cytoplasm (from 325.1 +/- 7.52 microm2 in the puncture specimens before administration of chemicals to 426.2 +/- 12.67 microm2 in the intraoperative specimens after their administration) and nuclei (from 127.9 +/- 3.45 to 179.7 +/- 7.86 microm2) and in the nuclear shape ratio (from 1.32 +/- 0.02 to 1.48 +/- 0.02).
Tuganova
T N
TN
Bolgova
L S
LS
Rodzaevskiĭ
S A
SA
Klapchuk
A G
AG
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D003581:Cytodiagnosis; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D015251:Epirubicin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged
D000970:Antineoplastic Agents; D015251:Epirubicin; D004317:Doxorubicin