title: Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae.
abstract: In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies were directed to top-down elucidation of single nutrient-induced pathways, recent investigations place the individual signalling pathways into signalling networks and pursue the identification of converging effector branches that orchestrate the dynamical responses to nutritional cues. In this review, we focus on Rim15, a protein kinase required in yeast for the proper entry into stationary phase (G0). Recent studies revealed that the activity of Rim15 is regulated by the interplay of at least four intercepting nutrient-responsive pathways.
authors.affiliation: Functional Biology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Belgium. joris.winderickx@bio.kuleuven.be.
authors.forename: Erwin
authors.initials: E
authors.lastname: Swinnen
authors.forename: Valeria
authors.initials: V
authors.lastname: Wanke
authors.forename: Johnny
authors.initials: J
authors.lastname: Roosen
authors.forename: Bart
authors.initials: B
authors.lastname: Smets
authors.forename: Frédérique
authors.initials: F
authors.lastname: Dubouloz
authors.forename: Ivo
authors.initials: I
authors.lastname: Pedruzzi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cameroni
authors.forename: Claudio
authors.initials: C
authors.lastname: De Virgilio
authors.forename: Joris
authors.initials: J
authors.lastname: Winderickx