Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga, Ishige okamurae.
The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC(50) values of 9.1 microM and 25.2 microM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes.
Ahn
M-J
MJ
Department of Crops Biotechnology, College of Life Sciences and Natural Resources, Jinju National University, Jinju, Gyeongnam 660-758, Korea.
Yoon
K-D
KD
Kim
C Y
CY
Kim
J H
JH
Shin
C-G
CG
Kim
J
J
D019380:Anti-HIV Agents / Q000494:pharmacology; D019427:HIV Integrase / Q000187:drug effects*; D019428:HIV Integrase Inhibitors / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology*; D000459:Phaeophyceae; D010936:Plant Extracts / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
D019380:Anti-HIV Agents; D019428:HIV Integrase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; C513811:diphlorethohydroxycarmalol; D019427:HIV Integrase; D054303:HIV Reverse Transcriptase