Outside influence: TLRs direct hematopoietic cell fates.
Toll-like receptors (TLRs) modulate immune responses indirectly by promoting the efficacy of antigen presentation. In this issue of Immunity, Nagai et al. (2006) demonstrate that TLR signals also bias hematopoietic progenitor cells toward myelopoiesis directly by replacing cytokine and differentiative cues.
Holl
T Matt
TM
Department of Immunology, Duke University, Durham, North Carolina 27710.
Kelsoe
Garnett
G
Department of Immunology, Duke University, Durham, North Carolina 27710. Electronic address: ghkelsoe@duke.edu.
D000818:Animals; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D038042:Myelopoiesis; D051193:Toll-Like Receptors / Q000378:metabolism*
D051193:Toll-Like Receptors