title: Imatinib mesylate-induced acute hepatitis in a patient treated for gastrointestinal stromal tumour.
abstract: We report the first case of hepatocellular injury occurring in a patient treated for metastatic gastrointestinal stromal tumour (GIST) with imatinib mesylate, with two positive rechallenges including one with 2.5% of the current therapeutic dosage. The patient could be treated later with sunitinib without liver toxicity. Grade 3-4 liver toxicity could occur in one out of 40 treated patients with imatinib for GIST, and fatalities have been reported. Regular monitoring of liver function tests is essential in patients treated with imatinib.
authors.affiliation: Unité d' hépatogastroentérologie, Centre Hospitalier, Pau, France. alex.pariente@wannadoo.fr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Pariente
authors.forename: Francine
authors.initials: F
authors.lastname: Etcharry
authors.forename: Valérie
authors.initials: V
authors.lastname: Cales
authors.forename: Yves
authors.initials: Y
authors.lastname: Laborde
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ferrari
authors.forename: Michel
authors.initials: M
authors.lastname: Biour
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001549:Benzamides; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate