Molecular mechanisms of metastasis.
A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.
Hoon
Dave S B
DS
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA. hoon@jwci.org
Kitago
Minoru
M
Kim
Joseph
J
Mori
Takuji
T
Piris
Adriano
A
Szyfelbein
Katherine
K
Mihm
Martin C
MC
Nathanson
S David
SD
Padera
Timothy P
TP
Chambers
Ann F
AF
Vantyghem
Sharon A
SA
MacDonald
Ian C
IC
Shivers
Steven C
SC
Alsarraj
Marwan
M
Reintgen
Douglas S
DS
Passlick
Bernward
B
Sienel
Wulf
W
Pantel
Klaus
K
D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology; D008207:Lymphatic Metastasis / Q000473:pathology / Q000503:physiopathology*; D008208:Lymphatic System / Q000503:physiopathology*; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D018715:Microscopy, Video; D009362:Neoplasm Metastasis / Q000473:pathology / Q000503:physiopathology*; D009857:Oncogenes / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology; D015398:Signal Transduction; D042582:Vascular Endothelial Growth Factor C / Q000502:physiology
D019707:Receptors, Chemokine; D042582:Vascular Endothelial Growth Factor C