[HPV-infection in esophageal cancer as possible predictive factor after neoadjuvant therapy].
BACKGROUND
Human papilloma virus (HPV) infection in oesophageal cancer cases was found 0-67% depending on different methods and geographical variances. Complete pathological response was in 30% of cases after neoadjuvant chemo-radiation (CRX). The aim of this study was to discover a possible relation between HPV-infection and response.


METHODS
DNA was extracted from 26 oesophageal cancer patients undergoing CRX and surgery. PCR and Southern Blot hybridisation was used to detect HPV-infection (HPV-16 and -18). Clinicopathological parameters and disease-free survival and overall survival was also analysed.


RESULTS
Complete response (26.9%) and partial response (38.5%) after CRX was correlated significantly with better prognosis. 6 patient had HPV-infection (3 from CR- and 3 from PR-group).


CONCLUSIONS
There was a correlation between HPV-infection and response, but further analysis is necessary. Both responder-groups had significantly better prognosis than non-responders.
Gábor
Bognár
B
Semmelweis Egyetem Budapest, II. sz. Sebészeti Klinika.
Imdahl
Andreas
A
György
Ledniczky
L
Pál
Ondrejka
O
D000970:Antineoplastic Agents / Q000627:therapeutic use; D015139:Blotting, Southern; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004279:DNA, Viral / Q000302:isolation & purification; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004279:DNA, Viral; D002945:Cisplatin; D005472:Fluorouracil