title: Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke.
abstract: To investigate the role of oral contraceptives and their interaction with thrombophilia in ischemic stroke, a case-control study on women with a first ischemic stroke when younger than 45 years was carried out. Oral contraceptives doubled the risk of ischemic stroke in the first 6-18 months of use and hyperhomocysteinemia increased the risk by 3.5-fold. Carriers of factor V Leiden or prothrombin G20210A were not found to have a statistically significant increased risk. The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia.
authors.affiliation: A. Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Italy. martin@policlinico.mi.it
authors.forename: Ida
authors.initials: I
authors.lastname: Martinelli
authors.forename: Tullia
authors.initials: T
authors.lastname: Battaglioli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Burgo
authors.forename: Sandro
authors.initials: S
authors.lastname: Di Domenico
authors.forename: Pier Mannuccio
authors.initials: PM
authors.lastname: Mannucci
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000139:chemically induced* / Q000453:epidemiology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology; D011516:Prothrombin / Q000235:genetics; D012189:Retrospective Studies; D020521:Stroke / Q000139:chemically induced* / Q000453:epidemiology; D019851:Thrombophilia / Q000139:chemically induced*; D044465:White People
chemical_list: D003276:Contraceptives, Oral; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin