Role of discs large homolog 5.
In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions.
Friedrichs
Frauke
F
Genetic Epidemiology of vascular disorders, Leibniz-Institute for Arteriosclerosis Research at the University of Muenster, Germany.
Stoll
Monika
M
D044466:Asian People / Q000235:genetics; D015984:Causality; D003424:Crohn Disease / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D004777:Environment; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D010641:Phenotype; D012737:Sex Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000502:physiology*; D044465:White People / Q000235:genetics
C114461:DLG5 protein, human; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins