Autologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction.
A randomized controlled study included 44 patients with acute myocardial infarction. It was found that intracoronary injection of bone marrow mononuclear cells is safe, ensures fixation of the injected cells in the myocardium, reduces blood levels of IL-1beta and TNF-alpha, increases the content insulin-like growth factor, and does not provoke malignant arrhythmias.
Karpov
R S
RS
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Popov
S V
SV
Markov
V A
VA
Suslova
T E
TE
Ryabov
V V
VV
Poponina
Yu S
YS
Krylov
A L
AL
Sazonova
S V
SV
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology*; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis; D007375:Interleukin-1 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism; D012038:Regeneration; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D050556:Fatty Acid-Binding Proteins; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I