title: Subarachnoid-pleural fistula as a complication of malignant pleural mesothelioma.
abstract: We report a 62-year-old male patient with asbestos-related malignant pleural mesothelioma who developed recurrent pleural effusions after surgical resection of paravertebral tumour masses. Pleural effusions were drained on several occasions with the patient suffering severe headaches and vascular dysregulation. Cytological studies of the pleural fluid showed no evidence of inflammatory or malignant cells. The fluid was interpreted as seroma despite its unusual transparency until magnetic resonance imaging was suggestive of a subarachnoid-pleural fistula; its presence was confirmed when beta-trace protein--a specific marker for cerebrospinal fluid--was added to the standard laboratory testing of the pleural effusion. A subarachnoid-pleural fistula has to be included in the differential diagnosis of patients with recurrent pleural effusions after surgical debulkment of malignant pleural mesothelioma. The beta-trace protein may help to establish this diagnosis especially in cases where important therapeutic consequences may need to be drawn.
authors.affiliation: Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, Ruhr-University of Bochum, Bochum, Germany.
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Heyer
authors.forename: Anja
authors.initials: A
authors.lastname: Theile
authors.forename: Heike
authors.initials: H
authors.lastname: Weisser
authors.forename: Joseph
authors.initials: J
authors.lastname: Reichert
authors.forename: Christoph
authors.initials: C
authors.lastname: Horch
authors.forename: Klaus-M
authors.initials: KM
authors.lastname: Mueller
authors.forename: Torsten T
authors.initials: TT
authors.lastname: Bauer
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D017809:Fatal Outcome; D005402:Fistula / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000134:cerebrospinal fluid; D054834:Lipocalins; D008279:Magnetic Resonance Imaging; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D035422:Pleural Cavity / Q000000981:diagnostic imaging* / Q000473:pathology; D010996:Pleural Effusion / Q000134:cerebrospinal fluid / Q000166:cytology; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D049291:Seroma / Q000150:complications / Q000175:diagnosis; D013346:Subarachnoid Space; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase