Subarachnoid-pleural fistula as a complication of malignant pleural mesothelioma.
We report a 62-year-old male patient with asbestos-related malignant pleural mesothelioma who developed recurrent pleural effusions after surgical resection of paravertebral tumour masses. Pleural effusions were drained on several occasions with the patient suffering severe headaches and vascular dysregulation. Cytological studies of the pleural fluid showed no evidence of inflammatory or malignant cells. The fluid was interpreted as seroma despite its unusual transparency until magnetic resonance imaging was suggestive of a subarachnoid-pleural fistula; its presence was confirmed when beta-trace protein--a specific marker for cerebrospinal fluid--was added to the standard laboratory testing of the pleural effusion. A subarachnoid-pleural fistula has to be included in the differential diagnosis of patients with recurrent pleural effusions after surgical debulkment of malignant pleural mesothelioma. The beta-trace protein may help to establish this diagnosis especially in cases where important therapeutic consequences may need to be drawn.
Heyer
Christoph M
CM
Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, Ruhr-University of Bochum, Bochum, Germany.
Theile
Anja
A
Weisser
Heike
H
Reichert
Joseph
J
Horch
Christoph
C
Mueller
Klaus-M
KM
Bauer
Torsten T
TT
D015415:Biomarkers / Q000134:cerebrospinal fluid; D017809:Fatal Outcome; D005402:Fistula / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000134:cerebrospinal fluid; D054834:Lipocalins; D008279:Magnetic Resonance Imaging; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D035422:Pleural Cavity / Q000000981:diagnostic imaging* / Q000473:pathology; D010996:Pleural Effusion / Q000134:cerebrospinal fluid / Q000166:cytology; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D049291:Seroma / Q000150:complications / Q000175:diagnosis; D013346:Subarachnoid Space; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase