title: Cellulose acetate/chitosan multimicrospheres preparation and ranitidine hydrochloride release in vitro.
abstract: A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200-350 microm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers.
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao, PR, China.
authors.forename: Hui Yun
authors.initials: HY
authors.lastname: Zhou
authors.forename: Xi Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Cheng Sheng
authors.initials: CS
authors.lastname: Liu
authors.forename: Xiang Hong
authors.initials: XH
authors.lastname: Meng
authors.forename: Chen Guang
authors.initials: CG
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Le Jun
authors.initials: le J
authors.lastname: Yu
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D011899:Ranitidine / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D006635:Histamine H2 Antagonists; C005062:acetylcellulose; D011899:Ranitidine; D002482:Cellulose; D048271:Chitosan