title: Folic acid and cognition in older persons.
abstract: Folic acid supplementation has drawn much attention in recent years for the prevention of Alzheimer's disease and cognitive decline. In this review, the authors describe how current evidence does not support the use of folic acid supplements to protect against cognitive decline. Although a few studies suggest that folic acid supplementation may provide neuroprotection among persons who are folate deficient, there is also data to indicate that supplementation in persons without folate deficiency may pose a risk to neurological function. Vitamin B12 deficiency is common in old age and may not be easy to recognise. Folic acid supplementation may mask the anaemia associated with vitamin B12 deficiency and, therefore, may delay treatment while allowing progression of neurological symptoms. Whether or not folic acid supplementation exacerbates neurological symptoms of vitamin B12 deficiency is not clear. Further studies are needed to determine the possible risks and benefits of folic acid supplementation in older persons.
authors.affiliation: Rush University Medical Center, Rush Alzheimer's Disease Center and Department of Neurological Sciences, 600 S. Paulina St., Suite 1022F, Chicago, IL 60612, USA. Julie_a_schneider@rush.edu
authors.forename: Julie A
authors.initials: JA
authors.lastname: Schneider
authors.forename: Christy C
authors.initials: CC
authors.lastname: Tangney
authors.forename: Martha Clare
authors.initials: MC
authors.lastname: Morris
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000517:prevention & control*; D019587:Dietary Supplements; D005492:Folic Acid / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D014803:Vitamin B Complex / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid