Lack of association between alpha2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation--preliminary report.
BACKGROUND
A genetic association/prospective follow-up study was conducted to investigate whether genetic variation of the alpha(2B)-adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation.


METHODS
For comparison of genotype frequency, a control group of 83 asymptomatic individuals was also studied. The end-point of the current study was the incidence of restenosis at 7 months of clinical follow-up.


RESULTS
The majority of patients (70/96) had the insertion/insertion genotype, fewer patients (23/96) had the insertion/deletion genotype and only 3/96 had the deletion/deletion genotype; overall the frequency distribution was not different from that of the control subjects. Restenosis occurred in 15 of the 96 patients.


CONCLUSIONS
In the population studied, alpha(2B)-adrenoreceptor polymorphisms were not found to predispose patients to an increased incidence of restenosis. Nevertheless, these findings should be considered as preliminary, taking into account the small number of patients that were studied and the rarity of the deletion/deletion genotype.
Manolis
Antonis S
AS
First Department of Cardiology, Evagelismos General Hospital of Athens, Athens, Greece.
Patsouras
Nikolaos
N
Ilias
Ioannis
I
Constantakopoulos
John
J
Pyriohou
Anastasia
A
Lymperopoulos
Anastasios
A
Spathas
Dionysios H
DH
Flordellis
Christodoulos S
CS
D000328:Adult; D000368:Aged; D017130:Angioplasty; D003327:Coronary Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*
C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2