Cytokines in dermatology.
Cytokines are polypeptides that are produced by various cell types and act in an autocrine or paracrine manner. They have many different biological actions and have been used in dermatology to treat a wide range of dermatologic diseases. In this paper we review some of the more commonly used cytokines in dermatology, including interferon-alpha and -gamma, interleukins-2 and -10, and granulocyte-macrophage colony-stimulating factor. We specifically examine their roles in the treatment of condyloma and verruca, hemangiomas, keloids, skin cancers, atopic dermatitis, psoriasis, Behcet disease, chronic granulomatous disease, wound healing, and cutaneous T cell lymphoma. In addition, some of the adverse effects associated with these cytokines are discussed.
Holman
Danah M
DM
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Kalaaji
Amer N
AN
D016207:Cytokines / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007372:Interferons / Q000009:adverse effects / Q000627:therapeutic use*; D007378:Interleukins / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012871:Skin Diseases / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
D016207:Cytokines; D003879:Dermatologic Agents; D007378:Interleukins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D007372:Interferons