Lung disease and brain development.
With the technical progress made in fetal and neonatal intensive care, perinatal mortality has decreased by 25% over the last decade and has expanded the surviving premature population. Prematurity drastically changes the environment of the developing organism. Striking evidence from a number of disciplines has focused attention on the interplay between the developing organism and the circumstances in which it finds itself. The environmental event during a sensitive period in development, induces injury and/or biological adaptations that lead to altered differentiation of tissues. The organism can express specific adaptive responses to its environment which include short-term changes in physiology as well as long-term adjustments. This review addresses these short-term as well as longer-term changes occurring in lung and brain tissue and illustrates how these changes can be studied using advanced imaging techniques such as magnetic resonance imaging
Huppi
Petra
P
Child Development Unit, Department of Pediatrics, University of Geneva, Geneva, Switzerland. Petra.Huppi@hcuge.ch
Sizonenko
Stephane
S
Amato
Maurizio
M
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000473:pathology* / Q000502:physiology; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008171:Lung Diseases / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D009473:Neuronal Plasticity; D018384:Oxidative Stress; D011859:Radiography
D005938:Glucocorticoids