neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities.
Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China. daishengjun_9@hotmail.com
Tao
Jia-Yi
JY
Liu
Ke
K
Jiang
Yong-Tao
YT
Shen
Li
L
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031363:Scutellaria / Q000737:chemistry*; D013329:Structure-Activity Relationship
D045785:Diterpenes, Clerodane