Cellular patterns of transcription factor expression in developing cortical interneurons.
Most gamma-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors in the medial ganglionic eminence and migrate tangentially to the pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB). Their patterns of expression change during interneuron differentiation and show distinct distributions within interneuron subpopulations in adult neocortex. This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes.
Cobos
Inma
I
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158-2611, USA.
Long
Jason E
JE
Thwin
Myo T
MT
Rubenstein
John L
JL
D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002449:Cell Aggregation; D002454:Cell Differentiation; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D066298:In Vitro Techniques; D007395:Interneurons / Q000166:cytology* / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D019579:Neocortex / Q000166:cytology* / Q000196:embryology / Q000254:growth & development*; D009415:Nerve Net / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D038081:Organogenesis / Q000502:physiology; D014018:Tissue Distribution; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors