[Advances in the endocrine factors affecting the development of gubernaculum testis].
The testicular gubernaculum plays an important role in testicular descent and development. Its differentiation and development are affected by many factors. Androgens, calcitonin gene-related peptide (CGRP), insulin-like factor 3 (INSL3), Müllerian inhibiting substance (MIS), epidermal growth factor (EGF) and environmental estrogens (EEs) are involved in gubernacular development. The effect of CGRP, INSL3 and especially EEs on genital system has been attracted more attention.
Deng
Wang-Dong
WD
Department of Urology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China. dengwangdong@sina.com
Jiang
Xue-Wu
XW
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D051379:Mice; D011506:Proteins / Q000502:physiology*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000196:embryology* / Q000502:physiology
D004967:Estrogens; D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins; D015740:Calcitonin Gene-Related Peptide