title: Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid.
abstract: In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reduced cytotoxicity and effective apoptosis when comparing with the native polyamide.
authors.affiliation: Department of Applied Chemistry, Beijing Institute of Technology, 100081 Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Yulin
authors.initials: Y
authors.lastname: Deng
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Peilong
authors.initials: P
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhai
authors.forename: Changjin
authors.initials: C
authors.lastname: Zhu
mesh_terms: D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D009757:Nylons / Q000378:metabolism* / Q000633:toxicity*; D010743:Phospholipids / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D009757:Nylons; D010743:Phospholipids; D004247:DNA