Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors.
Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
Ragab
Hanan M
HM
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, 23298-0540, USA.
Kim
Jin Sung
JS
Dukat
Małgorzata
M
Navarro
Hernán
H
Glennon
Richard A
RA
D002626:Chemistry, Pharmaceutical; D002794:Choline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004987:Ethers / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D018733:Nicotinic Antagonists / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000737:chemistry*; D013696:Temperature; D064569:alpha7 Nicotinic Acetylcholine Receptor
C513951:3-(2-(N,N,N-trimethylammonium)ethoxy)pyridine; D004987:Ethers; D005021:Ethylamines; D018733:Nicotinic Antagonists; D011725:Pyridines; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; D002794:Choline