title: Public-private collaboration for multidrug-resistant tuberculosis control in New York City.
abstract: METHODS
  An urban tuberculosis control program where an enhanced multidrug-resistant tuberculosis (MDR-TB) management plan coordinated care with multiple providers.
  
  
  OBJECTIVE
  To evaluate treatment outcomes of primary MDR-TB patients treated by multiple providers.
  
  
  METHODS
  Retrospective cohort study of tuberculosis patients from 1992-1997 provided that 1) their Mycobacterium tuberculosis isolates were resistant to at least isoniazid and rifampin, and 2) they had had < or = 30 days of anti-tuberculosis treatment prior to the collection of the first MDR-TB specimen.
  
  
  RESULTS
  More than 100 facilities and providers reported 856 MDR-TB patients. Treatment completion reached 70% among non-HIV-infected and 30% among HIV-infected persons; 57.2% of the cohort died prior to treatment completion, 26.5% completed treatment, 16.0% transferred out, refused treatment or were lost to follow-up and 0.2% are still in care. Diagnosis in the later years of the study or cavitation on chest radiograph was independently associated with increased completion among HIV-infected patients. Eight of the 227 (3.5%) patients who completed treatment relapsed (relapse rate 1.01/100 person-years), two with drug-susceptible strains.
  
  
  CONCLUSIONS
  A comprehensive MDR-TB control program improved the outcomes of both HIV-infected and non-infected individuals, despite management by multiple providers. Relapse was infrequent among patients who completed the recommended regimens.
authors.affiliation: New York City Department of Health and Mental Hygiene, NY 10007, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Munsiff
authors.forename: S D
authors.initials: SD
authors.lastname: Ahuja
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: C R
authors.initials: CR
authors.lastname: Driver
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009519:New York City; D017149:Private Sector; D017150:Public Sector; D012189:Retrospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000517:prevention & control*