title: Total synthesis and cytotoxicity evaluation of syrinenin-4-O-farnesylether and its analogues.
abstract: First synthesis of natural product, syrinenin-4-O-farnesylether (1), was carried out via two different paths. Four of its derivatives (9-12) were also prepared. Cytotoxicity screening of the selected compounds were performed on six tumour cell lines. Compound 12 exhibited prominent IC50 values of 1.9 microM and 0.8 microM on CNE and PC-3 cells, respectively.
authors.affiliation: Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zou
authors.forename: Jing-Xu
authors.initials: JX
authors.lastname: Gong
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Li
authors.forename: Lei-Xiang
authors.initials: LX
authors.lastname: Yang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Hu
authors.forename: Chang-Xin
authors.initials: CX
authors.lastname: Zhou
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Dou
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D019659:Asteraceae / Q000737:chemistry; D045744:Cell Line, Tumor; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; D004987:Ethers; C511994:syrinenin-4-O-farnesylether