title: [Sodium hyaluronate and an iodine complex--Hyiodine--new method of diabetic defects treatment].
abstract: Complicated diabetic defects are difficult to heal and frequently result in leg amputation. We have developed a new and unique system for wound treatment, which is based on combination of high molecular weight sodium hyaluronate with an iodine complex--Hyiodine. The aim of our study was to assess the effect of this new method of wound dressing on infected diabetic defects healing.
  
  
  METHODS
  The effect of Hyiodine was studied on 22 patients suffering from complicated foot diabetic wounds. Hyiodine was either spread directly over the wound, or (more frequently) gauze was immersed in Hyiodine and then put on/into the wound. Then several layers of dry gauze covered the wound.
  
  
  RESULTS
  Within 2-6 weeks after the onset of treatment all but two defects were filled with granulation tissue. Complete healing was evident in 18 patients within 6-20 weeks after the start of treatment, depending on the wound character, localization and extent. Two patients are still treated by Hyiodine, and significant improvement is apparent on their wound. Treatment was not successful in two subjects with ischemic defects due to simultaneous arterial occlusion.
  
  
  CONCLUSIONS
  We can conclude that the hyaluronan-iodine complex Hyiodine is efficient method for treatment of difficult to heal diabetic defects without complete arterial occlusion.
authors.affiliation: Klinika gerontologická a metabolická Lékarské fakulty UK a FN, Hradec Králové. pustik@lfhk.cuni.cz
authors.forename: L
authors.initials: L
authors.lastname: Sobotka
authors.forename: V
authors.initials: V
authors.lastname: Velebný
authors.forename: A
authors.initials: A
authors.lastname: Smahelová
authors.forename: M
authors.initials: M
authors.lastname: Kusalová
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001458:Bandages; D017719:Diabetic Foot / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007455:Iodine / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; C512827:hyaluronan-iodine complex; D006820:Hyaluronic Acid; D007455:Iodine