Cellular toxicity of carbon-based nanomaterials.
The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro on lung tumor cells. Our work clearly indicated that these materials are toxic while the hazardous effect is size-dependent. Moreover, cytotoxicity is enhanced when the surface of the particles is functionalized after an acid treatment.
Magrez
Arnaud
A
Institut de Physique de la Matière Complexe (IPMC), Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. arnaud.magrez@epfl.ch
Kasas
Sandor
S
Salicio
Valérie
V
Pasquier
Nathalie
N
Seo
Jin Won
JW
Celio
Marco
M
Catsicas
Stefan
S
Schwaller
Beat
B
Forró
Laszló
L
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D013499:Surface Properties
D037742:Nanotubes, Carbon