title: Cigarette smoking during pregnancy and hyperactive-distractible preschooler's: a follow-up study.
abstract: OBJECTIVE
  To study the association between intrauterine exposure to tobacco smoke and behavioural disorders in preschool children, primarily symptoms of inattention, hyperactivity and impulsivity but also hostile-aggressive and anxious-fearful symptoms.
  
  
  METHODS
  We conducted a follow-up study in 1355 singletons born to Danish-speaking mothers. Information on smoking habits during pregnancy and other lifestyle factors was obtained from self-administered questionnaires filled in during second and third trimester. Approximately 3.5 years later, the parents provided information on their child's behaviour using the self-administered Preschool Behaviour Questionnaire. The children were categorized into three not mutually exclusive behaviour groups: hyperactive - distractible (13.6%), hostile-aggressive (4.6%), and anxious-fearful (6.4%) children.
  
  
  RESULTS
  Compared with children of non-smokers, children born to women who smoked 10 or more cigarettes per day had a 60% increased risk of hyperactivity and distractibility perceived by the parents (OR 1.6; 95% CI 1.0-2.3; P < 0.05). The results were adjusted for maternal lifestyle factors and socioeconomic characteristics. Additional adjustment for perinatal factors and parental psychiatric hospitalization did not change the results substantially (OR 1.7; 95% CI 1.1-2.6). We found no statistically significant association between maternal smoking in pregnancy and hostile-aggressive and anxious-fearful behaviour in the offspring.
  
  
  CONCLUSIONS
  Exposure to tobacco smoke in utero was associated with hyperactive-distractible behaviour in preschool children.
authors.affiliation: Perinatal Epidemiology Research Unit, Department of Obstetrics and Paediatrics, Aarhus University Hospital, Skejby Sygehus, Denmark. kmlinnet@ki.au.dk
authors.forename: Karen
authors.initials: K
authors.lastname: Markussen Linnet
authors.forename: Carsten
authors.initials: C
authors.lastname: Obel
authors.forename: Else
authors.initials: E
authors.lastname: Bonde
authors.forename: Per
authors.initials: P
authors.lastname: Hove Thomsen
authors.forename: Niels Jørgen
authors.initials: NJ
authors.lastname: Secher
authors.forename: Kirsten
authors.initials: K
authors.lastname: Wisborg
authors.forename: Tine
authors.initials: T
authors.lastname: Brink Henriksen
mesh_terms: D002653:Child Behavior Disorders / Q000453:epidemiology*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000009:adverse effects*