Wide-range C-reactive protein efficacy in acute ischemic stroke patients.
OBJECTIVE
To compare the recently introduced wide-range C-reactive protein (wr-CRP) with the widely used high-sensitivity Behring Dade method (hs-CRP) in acute stroke/transient ischemic attack (TIA) patients.


METHODS
A total of 119 consecutive patients admitted to a tertiary medical center with acute ischemic stroke/TIA were included in the study. Venous blood was obtained for both assays during the first 24 h, 3-5 days, as well as 3-6 months thereafter.


RESULTS
A highly significant correlation (r=0.994, P<0.0001) was found between the two methods even when analyzed at three different time points. In addition, a similar correlation was noted between these two assays and other commonly used biomarkers, including white blood cell count, Westergren's sedimentation rate and quantitative fibrinogen.


CONCLUSIONS
Real-time, on-line and low-cost wr-CRP assay is a reasonable alternative to the Behring Dade hs-CRP method in acute stroke/TIA patients.
Shenhar-Tsarfaty
S
S
Department of Neurology, Tel Aviv Sourasky Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ben Assayag
E
E
Bova
I
I
Vered
Y
Y
Berliner
S
S
Rogowski
O
O
Shapira
I
I
Bornstein
N M
NM
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count / Q000592:standards; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology
D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein