Principles of therapeutic liver repopulation.
Liver repopulation by transplanted hepatocytes is a promising approach for many inborn errors of metabolism. In this review, examples of liver repopulation in animals and the implications of these models for clinical cell transplantation will be discussed.
Grompe
Markus
M
Oregon Stem Cell Center, Oregon Health & Science University, Portland, Oregon, USA. grompem@ohsu.edu
D002454:Cell Differentiation; D049109:Cell Proliferation; D022781:Hepatocytes / Q000378:metabolism / Q000637:transplantation*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism / Q000601:surgery*; D012641:Selection, Genetic; D019172:Transplantation Conditioning