title: Wegener's granulomatosis with a possible thyroidal involvement.
abstract: Wegener's granulomatosis (WG) is an autoimmune disorder characterized by the involvement of many organ systems. In patients with refractory disease, the efficacy of cyclophosphamide, corticosteroids and infliximab has been reported recently. Even in cases with serological response, disease progression has still been observed. Herein, we report a case of WG, most likely accompanied with subacute granulomatous thyroiditis while the patient was on cyclophosphamide, corticosteroid and infliximab therapy. As far as we know, this is the first time that such a copresentation has been observed, suggesting that mechanisms other than T-cell-mediated cytotoxicity may be important in the pathogenesis of granulomatous thyroiditis.
authors.affiliation: Division of Hematology, Department of Pathology, Baskent University School of Medicine, Adana Medical Center, Adana, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdogu
authors.forename: Can
authors.initials: C
authors.lastname: Boga
authors.forename: Filiz
authors.initials: F
authors.lastname: Bolat
authors.forename: Melek Eda
authors.initials: ME
authors.lastname: Ertorer
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D013968:Thyroiditis, Subacute / Q000209:etiology*; D017211:Treatment Failure; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide; D000069285:Infliximab