Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors.
Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells.
Ge
Woo-Ping
WP
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. shumin@ion.ac.cn
Yang
Xiu-Juan
XJ
Zhang
Zhijun
Z
Wang
Hui-Kun
HK
Shen
Wanhua
W
Deng
Qiu-Dong
QD
Duan
Shumin
S
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials; D006624:Hippocampus / Q000166:cytology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D018091:Receptors, AMPA / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D018091:Receptors, AMPA; D002118:Calcium