SIRT1, the human homologue to SIR2, is expressed in human skin and in cultured keratinocytes fibroblasts and HaCaT cells; and its levels is closely related to stress and aging.
Dal Farra
Claude
C
Vincience Research Center, Sophia Antipolis, France.
Domloge
N
N
D000328:Adult; D000375:Aging / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism* / Q000528:radiation effects; D008875:Middle Aged; D056564:Sirtuin 1; D037761:Sirtuins / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects; D013312:Stress, Physiological / Q000378:metabolism; D014466:Ultraviolet Rays
C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins