title: Attention-deficit/hyperactivity disorder: a plausible mouse model?
abstract: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and heterogeneous disorder, highly prevalent in children and characterized by three main components: inattention, lack of inhibitory control and hyperactivity. Epidemiological evidence reveals that ADHD is associated with nicotine exposure, mostly, with prenatal cigarette smoking. Mice deleted for the beta2-subunit gene of the neuronal nicotinic receptor are proposed as a simple and reliable animal model for ADHD.
  
  
  CONCLUSIONS
  Nicotinic agonists targeting the alpha4beta2 nicotinic receptors alleviate ADHD symptoms and may possibly contribute to an efficient therapy of ADHD children.
authors.affiliation: URA CNRS Récepteur et Cognition, Institut Pasteur, Paris, France. granon@pasteur.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Granon
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Changeux
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal