The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study.
BACKGROUND
Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region.


METHODS
In a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III.


RESULTS
A thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (P=0.27, OR 1.5, 95%CI 1.0-2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (P>0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (P>0.05).


CONCLUSIONS
There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia.
Yalinkaya
Ahmet
A
Dicle University School of Medicine, Department of Obstetrics and Gynecology, Diyarbakir, Turkey. ayalinkaya@dicle.edu.tr
Erdemoglu
Mahmut
M
Akdeniz
Nurten
N
Kale
Ahmet
A
Kale
Ebru
E
D000990:Antithrombin III / Q000032:analysis / Q000235:genetics; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D009154:Mutation / Q000235:genetics; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D020151:Protein C Deficiency / Q000097:blood / Q000235:genetics; D018455:Protein S Deficiency / Q000097:blood / Q000235:genetics; D011516:Prothrombin / Q000032:analysis / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)