title: Comparative in vitro activities of seven new beta-lactams, alone and in combination with beta-lactamase inhibitors, against clinical isolates resistant to third generation cephalosporins.
abstract: We examined the drug susceptibility pattern of Gram-negative bacilli to seven new beta-lactams. A total of 277 non-duplicate gramnegative bacilli strains belonging to the Enterobacteriaceae family, Pseudomonas and Acinetobacter species, isolated from various clinical samples were tested for susceptibility to imipenem, piperacillin/tazobactam, cefoperazone/sulbactam, ticarcillin/clavulanate, cefdinir, cefepime and cefpirome with the disk diffusion technique. The percentage resistance was low for imipenem (7.2%), piperacillin/tazobactam (2.8%), cefoperazone/sulbactam (5.4%). However, a high frequency of resistance was observed to ticarcillin/clavulanate (83.9%), cefdinir (70.6%), cefepime (45.5%) and cefpirome (84.4%). We conclude that imipenem, piperacillin/tazobactam and cefoperazone/sulbactam are effective antibiotics in our environment, whereas ticarcillin/clavulanate, cefdinir, cefepime and cefpirome are relatively uneffective.
authors.affiliation: Department of Microbiology, Government Medical College & Hospital, Sec -32, Chandigarh, India. varshagupta_99@yahoo.com
authors.forename: Varsha
authors.initials: V
authors.lastname: Gupta
authors.forename: Priya
authors.initials: P
authors.lastname: Datta
authors.forename: Nalini
authors.initials: N
authors.lastname: Agnihotri
authors.forename: Jagdish
authors.initials: J
authors.lastname: Chander
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011549:Pseudomonas / Q000187:drug effects; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams