[Vascular topography of glycemia in diabetes mellitus type 1 and in norm (theoretical analysis)].
Glycemia level in peripheral circulation is the basic parameter of diabetes diagnosing as well as a criteria of treatment effectiveness. Also there are a lot of the experimental data concerns glucose metabolism in different parts of the circulation. This permits to calculate so called circulatory topography of glycemia--glucose level in different parts of the circulation. As a result of the calculation was shown that in DM1 glycemia level is elevated in insulin-independent tissues even when glycemia level is normal in clinically useful peripheral circulation. These results can explain the predisposal of DM1 patients to diabetic retinopathy and nephropathy because eyes and kidney are the insulin-independent tissues. The reason why changes circulatory topography of glycemia in DM1 is changes in prime insulin delivery in circulation: insulin medication input not in the portal vein of hepar as in normal state but in peripheral circulation. It was shown that stable glycemia level in DM1 could be reached only in case of hepatic insulin-resistance.
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D001786:Blood Glucose / Q000032:analysis*; D001808:Blood Vessels; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008954:Models, Biological; D009928:Organ Specificity
D001786:Blood Glucose