S100A13, a new marker of angiogenesis in human astrocytic gliomas.
S100 proteins are Ca(2+)-binding polypeptides involved in the tumourigenesis of several human neoplasms. S100A13 is a key regulator of the stress-dependent release of FGF1, the prototype of the FGF protein family involved in angiogenesis. Indeed, S100A13 is a copper binding protein able to enhance the export of FGF1 in response to stress in vitro and to induce the formation of a multiprotein aggregate responsible for FGF1 release. We investigated the expression of S100A13 in human astrocytic gliomas in relation to tumour grading and vascularization. A series of 26 astrocytic gliomas was studied to evaluate microvessel density and to assess FGF1, S100A13 and VEGF-A expression. FGF1 was equally expressed in the vast majority of tumours, whereas S100A13 and VEGF-A were significantly up-regulated in high-grade vascularized gliomas. Moreover, both S100A13 and VEGF-A expression significantly correlated with microvessel density and tumour grading. These data suggest that the up-regulation of S100A13 and VEGF-A expression correlates with the activation of angiogenesis in high-grade human astrocytic gliomas.
Landriscina
M
M
Clinical Oncology Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Schinzari
G
G
Di Leonardo
G
G
Quirino
M
M
Cassano
A
A
D'Argento
E
E
Lauriola
L
L
Scerrati
M
M
Prudovsky
I
I
Barone
C
C
D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000098:blood supply* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009418:S100 Proteins; C511523:S100A13 protein, human; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors