Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
Letvin
Norman L
NL
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. nletvin@bidmc.harvard.edu
Mascola
John R
JR
Sun
Yue
Y
Gorgone
Darci A
DA
Buzby
Adam P
AP
Xu
Ling
L
Yang
Zhi-Yong
ZY
Chakrabarti
Bimal
B
Rao
Srinivas S
SS
Schmitz
Jörn E
JE
Montefiori
David C
DC
Barker
Brianne R
BR
Bookstein
Fred L
FL
Nabel
Gary J
GJ
D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D010957:Plasmids; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D016019:Survival Analysis; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D014779:Virus Replication
D018449:SAIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic