title: Rapid infusion of cold saline (4 degrees C) as adjunctive treatment of fever in patients with brain injury.
abstract: The use of rapid infusion of large-volume cold saline (CS) as an adjunctive therapy for treating refractory fever in nine patients is reported. A decline in temperature (39.2 +/- 0.3 vs 37.1 +/- 1.2 degrees C, p = 0.006) at 2 hours and fever burden (97.3 +/- 343.8 vs 734.3 +/- 422.3 degrees C*min, p = 0.02) at 12 hours was noted after CS bolus. Rapid infusion of large-volume CS may be used as an adjunct for inducing normothermia in refractory febrile patients.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA. nbadjatia@neuro.columbia.edu
authors.forename: Neeraj
authors.initials: N
authors.lastname: Badjatia
authors.forename: Michael
authors.initials: M
authors.lastname: Bodock
authors.forename: M
authors.initials: M
authors.lastname: Guanci
authors.forename: G A
authors.initials: GA
authors.lastname: Rordorf
mesh_terms: D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D015331:Cohort Studies; D005260:Female; D005334:Fever / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055502:Secondary Prevention; D012965:Sodium Chloride / Q000008:administration & dosage*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D012965:Sodium Chloride