title: [Study of chemical constituents in stem rind of Daphne giraldii].
abstract: OBJECTIVE
  To study the constituents with the pain-relieving activity from the stem rind of Daphne giraldii.
  
  
  METHODS
  The partition of the ethanol extract and chromatographic separation of the fractions were carried out by the monitoring of anelgesic pharmacological activity. The structures of the isolated compounds were determined by MS and NMR.
  
  
  RESULTS
  Four compounds were isolated from the pain-relieving fraction. Three of them were identified as diterpenes, gniditrin (1), gnidicin (2) and daphnetoxin (3). Compound 4 was determined as Z-octadecyl caffeate.
  
  
  CONCLUSIONS
  Compounds 1, 2 and 4 were isolated from the plant for the first time.
authors.affiliation: College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032364:Daphne / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000700:Analgesics; D002109:Caffeic Acids; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; C517789:octadecyl caffeate; C452759:daphnetoxin; C010461:gniditrin; C010459:gnidicin