title: Synthesis of conformationally constrained lysine analogues.
abstract: The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.
authors.affiliation: Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Ganorkar
authors.forename: Amarnath
authors.initials: A
authors.lastname: Natarajan
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mamai
authors.forename: José S
authors.initials: JS
authors.lastname: Madalengoitia
mesh_terms: D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D008239:Lysine