title: Encapsulation of pt-labelled DNA molecules inside carbon nanotubes.
abstract: Experiments on encapsulating Pt-labelled DNA molecules inside multiwalled carbon nanotubes (MWCNT) were performed under temperature and pressure conditions of 400K and 3 Bar. The DNA-CNT hybrids were purified via agarose gel electrophoresis and analyzed via high resolution transmission electron microscopy (HR-TEM) and energy dispersive X-ray spectroscopy (EDX). The results showed that the Pt-labelled DNA molecules attached to the outside walls of CNTs could be removed by electrophoresis. The HR-TEM and EDX results demonstrated that 2-3% of the Pt-labelled DNA molecules were successfully encapsulated inside the MWCNTs. The experimental study complements our previous molecular dynamics simulations on encapsulation of single stranded DNA oligonucleotides inside single wall carbon nanotubes under similar conditions in water. The van der Waals interaction between CNT and Pt-labelled DNA is believed to be the main driving force for this phenomenon. The DNA-CNT molecular complex could be further explored for potential applications in bio-nanotechnology.
authors.affiliation: Max Planck Institute for Metals Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany.
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
authors.forename: Cengiz S
authors.initials: CS
authors.lastname: Ozkan
authors.forename: Sathyajith
authors.initials: S
authors.lastname: Ravindran
authors.forename: Yong
authors.initials: Y
authors.lastname: Kong
authors.forename: Huajian
authors.initials: H
authors.lastname: Gao
mesh_terms: D002244:Carbon / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D010984:Platinum / Q000737:chemistry*
chemical_list: D010984:Platinum; D002244:Carbon; D004247:DNA