title: In-vivo coronary flow profiling based on biplane angiograms: influence of geometric simplifications on the three-dimensional reconstruction and wall shear stress calculation.
abstract: BACKGROUND
  Clinical studies suggest that local wall shear stress (WSS) patterns modulate the site and the progression of atherosclerotic lesions. Computational fluid dynamics (CFD) methods based on in-vivo three-dimensional vessel reconstructions have recently been shown to provide prognostically relevant WSS data. This approach is, however, complex and time-consuming. Methodological simplifications are desirable in porting this approach from bench to bedside. The impact of such simplifications on the accuracy of geometry and wall shear stress calculations has to be investigated.
  
  
  METHODS
  We investigated the influence of two methods of lumen reconstruction, assuming circular versus elliptical cross-sections and using different resolutions for the cross-section reconstructions along the vessel axis. Three right coronary arteries were used, of which one represented a normal coronary artery, one with "obstructive", and one with "dilated" coronary atherosclerosis. The vessel volume reconstruction was performed with three-dimensional (3D) data from a previously validated 3D angiographic reconstruction of vessel cross-sections and vessel axis.
  
  
  RESULTS
  The difference between the two vessel volumes calculated using the two evaluated methods is less than 1 %. The difference, of the calculated pressure loss, was between 2.5% and 8.5% for the evaluated methods. The distributions of the WSS histograms were nearly identical and strongly cross-correlated (0.91-0.95). The good agreement of the results was confirmed by a Chi-square test.
  
  
  CONCLUSIONS
  A simplified approach to the reconstruction of coronary vessel lumina, using circular cross-sections and a reduced axial resolution of about 0.8 mm along the vessel axis, yields sufficiently accurate calculations of WSS.
authors.affiliation: Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Berlin, Germany. wellnhofer@dhzb.de
authors.forename: Ernst
authors.initials: E
authors.lastname: Wellnhofer
authors.forename: Leonid
authors.initials: L
authors.lastname: Goubergrits
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kertzscher
authors.forename: Klaus
authors.initials: K
authors.lastname: Affeld
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D004548:Elasticity; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D033081:Shear Strength; D013314:Stress, Mechanical