title: Effect of artificial lung compliance on in vivo pulmonary system hemodynamics.
abstract: This study examined the effect of artificial lung compliance (C) on pulmonary system (PS) impedance and right ventricular function during in-series attachment of the MC3 Biolung in adult sheep. Compliances, C, of 0-20 ml/mm Hg were tested at the Biolung inlet. Results indicate the PS 0 harmonic input impedance modulus was not affected by C. The PS first harmonic input impedance modulus (Z1) was 10.9 +/- 3.2 mm Hg/(l/min) at C = 0 ml/mm Hg and minimized to 2.41 +/- 0.79 mm Hg/(l/min) at C > or = 0.5 ml/mm Hg. Cardiac output was 58% +/- 10% of its pre-Biolung attachment, baseline value at C = 0 ml/mm Hg and was maximized to an average of 75% +/- 11% at C > or = 0.5 ml/mm Hg. The left ventricular lateral-to-anteroposterior axis length ratio, which decreases with leftward septal shift, increased with C from 0.52 +/- 0.12 at C = 0 ml/mm Hg to 0.76 +/- 0.06 at C = 5 ml/mm Hg (p < 0.05), but decreased slightly with C at C > 5 ml/mm Hg. Therefore, the ideal C for right ventricular function is at least 0.5 ml/mm Hg and may be as high as 5 ml/mm Hg to minimize septal shift.
authors.affiliation: Department of Surgery and Bioengineering, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sato
authors.forename: John W
authors.initials: JW
authors.lastname: McGillicuddy
authors.forename: Grant W
authors.initials: GW
authors.lastname: Griffith
authors.forename: Amy M
authors.initials: AM
authors.lastname: Cosnowski
authors.forename: Sean D
authors.initials: SD
authors.lastname: Chambers
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Hirschl
authors.forename: Robert H
authors.initials: RH
authors.lastname: Bartlett
authors.forename: Keith E
authors.initials: KE
authors.lastname: Cook
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001698:Biomedical Engineering; D004562:Electrocardiography; D006439:Hemodynamics / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D008297:Male; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D015656:Respiratory Mechanics; D012756:Sheep; D016278:Ventricular Function, Right / Q000502:physiology