title: Family and twin studies in inflammatory bowel disease.
abstract: Studies examining the inheritance of inflammatory bowel disease (IBD) within different family groups have been the basis for recent molecular advances in the genetics of IBD. The derived heritability in Crohn's disease (CD) is higher than in many other complex diseases. The risk of IBD is highest in first-degree relatives of a CD proband, but first-degree relatives of a proband suffering from ulcerative colitis (UC) and more distant relatives are also at increased risk. Disease concordance rates in IBD have been examined in multiplex families and in three large European twin studies.
authors.affiliation: Department of Transplantation and Liver Surgery, Helsinki University Hospital, Finland. leena.halme@hus.fi
authors.forename: Leena
authors.initials: L
authors.lastname: Halme
authors.forename: Paulina
authors.initials: P
authors.lastname: Paavola-Sakki
authors.forename: Ulla
authors.initials: U
authors.lastname: Turunen
authors.forename: Maarit
authors.initials: M
authors.lastname: Lappalainen
authors.forename: Martti
authors.initials: M
authors.lastname: Farkkila
authors.forename: Kimmo
authors.initials: K
authors.lastname: Kontula
mesh_terms: D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004200:Diseases in Twins / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors; D018433:Twin Studies as Topic