title: [Evaluation of the effect of fertility-saving surgery on young patients with malignant ovarian tumors].
abstract: OBJECTIVE
  To evaluate the impact of fertility-saving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors.
  
  
  METHODS
  A retrospective analysis was done on 38 patients with ovarian malignant germ cell tumors, 22 patients with malignant epithelial tumors and 4 patients with sexual cord mesenchymal tumors receiving conservative treatments. Outcomes such as menstruation and reproduction ability were assessed.
  
  
  RESULTS
  Fifty-nine among 64 patients have been alive up to now (92%). The overall survival rate for ovarian epithelial malignancies, malignant germ cell tumors and sexual cord mesenchymal tumors were 95% (21/22), 89% (34/38) and 4/4, respectively. Fifteen patients received second operation and recurrence was found in 6 patients. Among the 59 surviving patients, 53 had normal menstruation. Thirteen patients among 20 patients who wanted to get pregnant had 15 pregnancies and 9 successful deliveries.
  
  
  CONCLUSIONS
  The management of fertility-saving surgery on patients with ovarian malignant germ cell tumors, whatever the stagings are, is a safe option. For patients with ovarian epithelial carcinomas, fertility-saving surgery is only indicated for low-stage (stage I), high-grade (G1), and patients who hope to maintain fertility function eagerly. Cisplatinum-based combination chemotherapy is necessary. Standardized chemotherapy has no effect on fertility function.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ming-rong
authors.initials: MR
authors.lastname: Xi
authors.forename: Min-min
authors.initials: MM
authors.lastname: Hou
authors.forename: Ze-yi
authors.initials: ZY
authors.lastname: Cao
authors.forename: Chong-shu
authors.initials: CS
authors.lastname: Zhang
authors.forename: Zhi-lan
authors.initials: ZL
authors.lastname: Peng
authors.forename: Hong-jing
authors.initials: HJ
authors.lastname: Wang
authors.forename: Ai
authors.initials: A
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D018237:Germinoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015203:Reproducibility of Results; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome