title: Role of recombinant activated factor VII in securing haemostatic failure in gun shot trauma.
abstract: Uncontrolled bleeding is the leading cause of mortality in the trauma victims. Massive bleeding after traumatic injury is a result of surgical and coagulopathic bleeding. We describe a case of gun shot injury brought to the hospital in a collapsed state because of massive blood loss in the abdominal cavity. Surgical intervention secured the surgical bleeding but coagulopathic bleeding continued which was controlled with Recombinant activated factor VII (rFVIIa). Guidelines of the use of factor VII in trauma are presented.
authors.affiliation: Bismillah Taqee Institute of Health Sciences and Blood Diseases Centre, Karachi.
authors.forename: Tahir
authors.initials: T
authors.lastname: Shamsi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Tufail
authors.forename: Mariam
authors.initials: M
authors.lastname: Aftab
authors.forename: Saqib
authors.initials: S
authors.lastname: Ansari
mesh_terms: D000328:Adult; D004636:Emergency Service, Hospital; D005167:Factor VII / Q000627:therapeutic use*; D015942:Factor VIIa / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D014948:Wounds, Gunshot / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa