Fc receptor-positive cells in remyelinating multiple sclerosis lesions.
The capacity for spontaneous remyelination in cases of multiple sclerosis (MS) is limited and lesions are not fully repaired. Recent evidence has shown that oligodendrocyte precursor cells and immature oligodendrocytes (OPC/iOligs) are preserved in MS lesions. Induced differentiation of these cells into myelinating cells may ultimately lead to a novel remyelination therapy. A previous study showed that the gamma chain of immunoglobulin Fc receptors (FcRgamma), expressed in OPC/iOligs, is essential for their differentiation. Whether FcRgamma is expressed in preserved OPC/iOligs within MS lesions, however, remains uncertain. In the present study, we examined 10 autopsy cases of MS for the expression of FcRgamma both in remyelinating areas and demyelinated plaques. The expression of FcRgamma was confirmed in both OPC/iOligs and microglia in MS lesions. Statistical analysis showed that the density of FcRgamma-positive OPC/iOligs was approximately 3 times greater in remyelinating areas compared with demyelinated plaques; the opposite was true of FcRgamma-positive microglia. The distribution of FcRgamma-negative OPC/iOligs did not differ between the 2 types of lesions. Thus, an increase in FcRgamma-positive OPC/iOligs and a decrease in FcRgamma-positive microglia, but not in FcRgamma-negative OPC/iOligs, are associated with spontaneous remyelination in MS brains, suggesting a possible role for FcRgamma in the induction of remyelination.
Nakahara
Jin
J
Department of Anatomy, Keio University School of Medicine, Tokyo, Japan. nakahara@jnn.sakura.ne.jp
Aiso
Sadakazu
S
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D009836:Oligodendroglia / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism; D000099216:Chondroitin Sulfate Proteoglycan 4
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D000941:Antigens; D051792:Basic Helix-Loop-Helix Proteins; D000949:Histocompatibility Antigens Class II; D007141:Immunoglobulin Fc Fragments; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4; C405707:OLIG1 protein, human