title: Cloning and expression analysis of takeout/JHBP family genes of silkworm, Bombyx mori.
abstract: A Bombyx EST cDNA database was searched using the Drosophila takeout gene and nine cDNAs were obtained. The homology search suggested that these genes are widespread in insects and organize a large gene family, and that they have hydrophobic ligands. A phylogenetic tree indicated that the genes are first divided into two large groups, juvenile hormone binding protein and other protein genes, and the latter group diversified within a short time at an early stage. The expression study of five Bombyx genes indicated that they are expressed in various tissues and are regulated by development and feeding conditions. The Bombyx genes might have roles related to the regulation of metabolism, growth or development related to nutritional conditions.
authors.affiliation: Division of Molecular Science, Graduate School of Science and Technology, Kobe University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Su
authors.forename: A
authors.initials: A
authors.lastname: Emi
authors.forename: K
authors.initials: K
authors.lastname: Mita
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D012831:Bombyx / Q000235:genetics* / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D005260:Female; D015870:Gene Expression; D017344:Genes, Insect / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013217:Starvation / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C411066:TO protein, Drosophila; C035606:juvenile hormone-binding protein, insect