Apoptosis and autoimmune diseases.
Apoptosis is a process by which harmful or useless cells are eliminated. This process can be divided into two steps, death and engulfment. Molecules involved in apoptosis have been identified, and mouse lines deficient in these genes have been established. Among these deficiencies, those in the death receptor system or the engulfment of apoptotic cells cause systemic lupus erythematosus, whereas inefficient DNA degradation causes anemia by activating innate immunity, leading to death during embryogenesis. The apoptotic process and the diseases caused by defects in it are briefly reviewed.
Nagata
Shigekazu
S
Laboratory of Genetics, Department of Integrated Biology, Graduate School of Frontier Bioscience, Osaka University, Japan. nagata@genetic.med.osaka-u.ac.jp
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000473:pathology*; D006801:Humans