Use of cyclopropanols as conformational constraints in RCM.
[reaction: see text] Sequential application of the Kulinkovich cyclopropanation of carboxylic esters and RCM of the resulting cis-dialkenyl-tethered cyclopropanols provides an expedient route to functionalized medium-sized carbocycles. Subsequent elaboration of the cyclopropanol functionality, such as one-carbon ring expansion, to afford synthetically useful alpha,beta-enones is also worth noting.
Lysenko
Ivan L
IL
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Lee
Hyung Goo
HG
Cha
Jin Kun
JK