title: Effect of ZnO addition on bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics containing apatite and wollastonite.
abstract: Some ceramics show bone-bonding ability, i.e. bioactivity. Apatite formation on ceramics is an essential condition to bring about direct bonding to living bone when implanted into bony defects. A controlled surface reaction of the ceramic is an important factor governing the bioactivity and biodegradation of the implanted ceramic. Among bioactive ceramics, glass-ceramic A-W containing apatite and wollastonite shows high bioactivity, as well as high mechanical strength. In this study, glass-ceramics containing zinc oxide were prepared by modification of the composition of the glass-ceramic A-W. Zinc oxide was selected to control the reactivity of the glass-ceramics since zinc is a trace element that shows stimulatory effects on bone formation. Glass-ceramics were prepared by heat treatment of glasses with the general composition: xZnOx(57.0-x)CaOx35.4SiO(2)x7.2P(2)O(5)x0.4CaF(2) (where x=0-14.2mol.%). Addition of ZnO increased the chemical durability of the glass-ceramics, resulting in a decrease in the rate of apatite formation in a simulated body fluid. On the other hand, the release of zinc from the glass-ceramics increased with increasing ZnO content. Addition of ZnO may provide bioactive CaO-SiO(2)-P(2)O(5)-CaF(2) glass-ceramics with the capacity for appropriate biodegradation, as well as enhancement of bone formation.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma-shi, Nara 630-0192, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kamitakahara
authors.forename: C
authors.initials: C
authors.lastname: Ohtsuki
authors.forename: H
authors.initials: H
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Tanihara
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D003198:Computer Simulation; D019563:Mechanics; D008855:Microscopy, Electron, Scanning; D019279:Resin Cements / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry*; D013696:Temperature; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; C116882:CaO-SiO2-P2O5-CaF2 glass; D017610:Calcium Compounds; D019279:Resin Cements; D017640:Silicates; C023506:Glass ceramics; C031293:calcium silicate; D015034:Zinc Oxide