title: Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus.
abstract: To assess whether pathogenic endothelial dysfunction is involved in acute idiopathic tinnitus we enrolled 44 patients and 25 healthy volunteers. In blood from the internal jugular vein and brachial vein we determined malonaldehyde, 4-hydroxynonenal, myeloperoxidase, glutathione peroxidase, nitric oxide, L-arginine and L-ornitine, thrombomodulin (TM) and von Willebrand factor (vWF) activity during tinnitus and asymptomatic period. Higher plasma concentrations of oxidative markers and L-arginine, and lower nitric oxide and L-ornitine levels were observed in jugular blood of patients with tinnitus, there being a significant difference between brachial and jugular veins. TM and vWF activity were significantly higher in patients' jugular blood than in brachial blood. Our results suggest oxidant, TM, vWF activity production are increased and nitric oxide production reduced in brain circulation reflux blood of patients with acute tinnitus. These conditions are able to cause a general cerebro-vascular endothelial dysfunction, which in turn induce a dysfunction of microcirculation in the inner ear.
authors.affiliation: Department of Internal Medicine, Catania University, Catania, Italy. sergio.neri4@tin.it
authors.forename: Sergio
authors.initials: S
authors.lastname: Neri
authors.forename: Santo
authors.initials: S
authors.lastname: Signorelli
authors.forename: Davide
authors.initials: D
authors.lastname: Pulvirenti
authors.forename: Barbara
authors.initials: B
authors.lastname: Mauceri
authors.forename: Danila
authors.initials: D
authors.lastname: Cilio
authors.forename: Fabio
authors.initials: F
authors.lastname: Bordonaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Abate
authors.forename: Donatella
authors.initials: D
authors.lastname: Interlandi
authors.forename: Maria
authors.initials: M
authors.lastname: Misseri
authors.forename: Luca
authors.initials: L
authors.lastname: Ignaccolo
authors.forename: Marina
authors.initials: M
authors.lastname: Savastano
authors.forename: Rita
authors.initials: R
authors.lastname: Azzolina
authors.forename: Calogero
authors.initials: C
authors.lastname: Grillo
authors.forename: Agostino
authors.initials: A
authors.lastname: Messina
authors.forename: Agostino
authors.initials: A
authors.lastname: Serra
authors.forename: Alkaterini
authors.initials: A
authors.lastname: Tsami
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D014012:Tinnitus / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D009569:Nitric Oxide