[Expression of midkine in eutopic and ectopic endometrium of patients with severe endometriosis and its clinical significance].
OBJECTIVE
To investigate the expression of midkine (MK) in eutopic and ectopic endometrium of patients with severe endometriosis and its clinical significance.


METHODS
Immunohistochemical streptavidin-biotin peroxidase (SP) method was used to detect MK expression and microvessel density (MVD) in eutopic and ectopic endometrium. Specimens of eutopic and ectopic endometrium were collected from 41 patients with serious endometriosis (study group) and 32 patients with uterine fibroid (control group).


RESULTS
The positive rate of MK expression in the eutopic endometrium from study group was 63% (26/41). It was significantly higher than that in the ectopic endometrium from study group was 29% (12/41) and the eutopic endometrium from control group was 22% (7/32, P < 0.05). MK expression was positively correlated to microvessel density (r = 0.637, P < 0.05).


CONCLUSIONS
Over-expression of MK protein is showed in the eutopic endometrium of patients with severe endometriosis and correlated to endometriotic angiogenesis. The change of MK expression in eutopic endometrium may be related to the pathogenesis of severe endometriosis.
Zhu
Li-ming
LM
Department of Obstetrics and Gynecology, Huzhou Central Hospital, Huzhou of Zhejiang Province 313000, China.
Zhang
Tong-hua
TH
Dai
Li-cheng
LC
Ping
Jin-liang
JL
Huang
Xiao-hong
XH
Yuan
Hui-qin
HQ
D000328:Adult; D016207:Cytokines / Q000096:biosynthesis*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000098:blood supply / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000078792:Midkine; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology
D016207:Cytokines; D000078792:Midkine