A diversity oriented synthesis of 3'-O-modified nucleoside triphosphates for DNA 'sequencing by synthesis'.
The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis.
Lu
Genliang
G
Department of Chemistry, Texas A&M University, PO Box 300012, College Station, TX 77842-3012, USA.
Burgess
Kevin
K
D009711:Nucleotides / Q000138:chemical synthesis*; D017422:Sequence Analysis, DNA / Q000379:methods*
D009711:Nucleotides