Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas.
Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern. Microvessel density (MVD) has been correlated to clinical outcome in astrocytomas, but its impact in oligodendrogliomas and mixed tumors is not sure. The pro-angiogenic chemokine stromal cell-derived factor (SDF-1/CXCL12) and its receptor CXC chemokine receptor 4 (CXCR4) have been described in low-grade gliomas, with a correlation between CXCL12 expression and shorter time to progression (TTP). The intermediate filament Nestin is expressed in proliferating vessels. Platelet-derived growth factor B (PDGF-B) and its receptor PDGFR-beta are also involved in angiogenesis and malignant progression in gliomas.
Calatozzolo
Chiara
C
Department of Neurology, Istituto Nazionale Neurologico C. Besta, Milano, Italy.
Maderna
Emanuela
E
Pollo
Bianca
B
Gelati
Maurizio
M
Marras
Carlo
C
Silvani
Antonio
A
Croci
Danilo
D
Boiardi
Amerigo
A
Salmaggi
Andrea
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000098:blood supply* / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis* / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000032:analysis*; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis; D064231:Nestin; D009837:Oligodendroglioma / Q000098:blood supply* / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D020574:Proto-Oncogene Proteins c-sis / Q000032:analysis; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000032:analysis; D019718:Receptors, CXCR4 / Q000032:analysis
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D020574:Proto-Oncogene Proteins c-sis; D019718:Receptors, CXCR4; D020797:Receptor, Platelet-Derived Growth Factor beta