title: Analysis of Rhes activation state and effector function.
abstract: Rhes/RASD2 is a novel Ras homolog with almost restricted expression in the brain and highly enriched in the striatum, where it is controlled by thyroid hormone during the postnatal period. Little is known about its biochemical properties and cell signaling function, but the data available so far indicate that Rhes is constitutively bound to GTP and activates PI3K, and, on the other hand, interferes with cAMP/PKA pathway activation induced by G protein-coupled receptors.
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Autonoma de Madrid, Madrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Bernal
authors.forename: Piero
authors.initials: P
authors.lastname: Crespo
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D051379:Mice; D051381:Rats
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; C442475:Rasd2 protein, rat