Genetics of spondyloarthritis.
This chapter reviews evidence from family and twin studies supporting the strong genetic predisposition of the spondyloarthritides (SpA), which is only partially attributable to the major histocompatibility locus. The current concept of SpA heterogeneity has been challenged by family studies which showed that all articular and extra-articular manifestations were linked together, and most likely to the same genetic factors.
Breban
Maxime
M
Institut Cochin, INSERM U567/CNRS UMR8104/IFR116, Hôpital Cochin, Paris, France. maxime.braban@cch.ap-hop-paris.fr
D000818:Animals; D004195:Disease Models, Animal; D005192:Family Health; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D017720:Molecular Epidemiology; D025241:Spondylarthritis / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D018433:Twin Studies as Topic