title: Small size ductal carcinoma in situ of the breast: predictors of positive margins after local excision.
abstract: One of the most important predictors of local recurrence after local excision of ductal carcinoma in situ (DCIS) is margin status. The aim was to study the association between margin status and clinical, radiological, and pathological characteristics and to determine predictors of positive margins after local excision of small size (< or = 4 cm) DCIS. Data were tested for differences regarding margin status, and logistic regression was used to determine predictors of margin status. The population consisted of 105 cases. Overall, 51 cases (49%) had free margins and 54 cases (51%) had positive margins. Positive margins were more often associated with a mean mammographic tumor size of 2.1 cm (P = 0.044) and absence of fine granular calcifications (P = 0.004). Also, high-grade (P = 0.013) and a mean pathological size of 3.2 cm (P < 0.001) were associated with positive margins. The only independent predictor of margin status was pathological grade (P = 0.010).
authors.affiliation: Department of Surgery, Martini Hospital, Groningen, The Netherlands. m.a.j.de.roos@chir.umcg.nl
authors.forename: Marnix A
authors.initials: MA
authors.lastname: de Roos
authors.forename: Alex D
authors.initials: AD
authors.lastname: Groote
authors.forename: Ruud M
authors.initials: RM
authors.lastname: Pijnappel
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Post
authors.forename: Jaap
authors.initials: J
authors.lastname: de Vries
authors.forename: Peter C
authors.initials: PC
authors.lastname: Baas
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012189:Retrospective Studies