title: PGMC: a framework for probabilistic graphic model combination.
abstract: Decision making in biomedicine often involves incorporating new evidences into existing or working models reflecting the decision problems at hand. We propose a new framework that facilitates effective and incremental integration of multiple probabilistic graphical models. The proposed framework aims to minimize time and effort required to customize and extend the original models through preserving the conditional independence relationships inherent in two types of probabilistic graphical models: Bayesian networks and influence diagrams. We present a four-step algorithm to systematically combine the qualitative and the quantitative parts of the different models; we also describe three heuristic methods for target variable generation to reduce the complexity of the integrated models. Preliminary results from a case study in heart disease diagnosis demonstrate the feasibility and potential for applying the proposed framework in real applications.
authors.affiliation: Medical Computing Laboratory, National University of Singapore.
authors.forename: Chang An
authors.initials: CA
authors.lastname: Jiang
authors.forename: Tze-Yun
authors.initials: TY
authors.lastname: Leong
authors.forename: Kim-Leng
authors.initials: KL
authors.lastname: Poh
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D003661:Decision Support Techniques; D005240:Feasibility Studies; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D015233:Models, Statistical; D016571:Neural Networks, Computer