Drug-eluting stents.
Percutaneous coronary intervention has evolved dramatically over the past 25 years as coronary stents replaced stand-alone balloon angioplasty. Improvements in stents were made in the 1990s, but a breakthrough occurred in early 2000 with the development of stents that eluted pharmacology agents directly into the vessel wall by means of a controlled release from a durable polymer coating. Various drug-eluting stents were developed,each varying with its delivery platform, polymer coating (or absence of coating),and drug selected for elution. This article describes the clinically available and late developmental drug-eluting stent programs targeted for treating patients who have coronary artery disease.
Popma
Jeffrey J
JJ
Department of Internal Medicine (Cardiovascular Division), Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. jpopma@partners.org
Tulli
Mark
M
D015906:Angioplasty, Balloon, Coronary; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003327:Coronary Disease / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D011474:Prosthesis Design; D015607:Stents
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents