title: Intravenous administration of acetylsalicylic acid during endovascular treatment of cerebral aneurysms reduces the rate of thromboembolic events.
abstract: OBJECTIVE
  The purpose of this study is to analyze the effect of a modified intraoperative anticoagulation strategy including acetylsalicylic acid (ASA) on complication rates during endovascular coil embolization.
  
  
  METHODS
  Two hundred and sixty-one cerebral aneurysms were treated in 247 patients by endovascular coil embolization from January 2001 to September 2004. Additional intravenous administration of 250 mg ASA was applied since January 2003. Patients treated before (-ASA; n=102 aneurysms) and after that date (+ASA; n=159 aneurysms) were compared. End points were rates of thromboembolism and severity of hemorrhages after intraoperative aneurysm rupture.
  
  
  RESULTS
  Thromboembolic events during the procedure were observed more often in the -ASA group (18/102 aneurysms, 17.6%) in comparison with the +ASA group (14/159 aneurysms, 8.8%; P=0.028; Fisher exact test). Aneurysm perforation events occurring during or immediately after the procedure were observed equally often in the -ASA group (7/102 aneurysms, 6.9%) in comparison with the +ASA group (10/159 aneurysms, 6.3%).
  
  
  CONCLUSIONS
  Intravenous application of ASA is feasible and safe during interventional aneurysm embolization. ASA seems to be associated with a significant reduction in the rate of thromboembolic events without increase in the rate or severity of intraoperative bleedings.
authors.affiliation: Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Ries
authors.forename: Jan-Hendrik
authors.initials: JH
authors.lastname: Buhk
authors.forename: Thomas
authors.initials: T
authors.lastname: Kucinski
authors.forename: Einar
authors.initials: E
authors.lastname: Goebell
authors.forename: Ulrich
authors.initials: U
authors.lastname: Grzyska
authors.forename: Hermann
authors.initials: H
authors.lastname: Zeumer
authors.forename: Jens
authors.initials: J
authors.lastname: Fiehler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D004341:Drug Evaluation; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000628:therapy*; D007430:Intraoperative Care; D007431:Intraoperative Complications / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000209:etiology; D013923:Thromboembolism / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors; D006493:Heparin; D001241:Aspirin