Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth.
The case of the gastrointestinal production of ethanol from Candida albicans and Saccharomyces cerevisiae in a Caucasian man with chronic intestinal pseudo-obstruction is reported. The patient, who declared to have always abstained from alcohol, was hospitalized for abdominal pain, belching and mental confusion. The laboratory findings showed the presence of ethanol in the blood. Gastric juice and faecal microbiological cultures were positive for C. albicans and S. cerevisiae. At home, he was on oral antibiotic therapy with amoxicillin plus clavulanic acid for a small bowel bacterial overgrowth, associated with a simple sugar-rich diet. Twenty-four hours after stopping both the antibiotic therapy and the simple sugar-rich diet, the blood ethanol disappeared. A provocative test, performed by giving amoxicillin plus clavulanic acid associated with the simple sugar-rich diet was followed by the reappearance of ethanol in the blood. A review of the literature is reported.
Spinucci
Giulio
G
Centre for Chronic Intestinal Failure, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
Guidetti
Mariacristina
M
Lanzoni
Elisabetta
E
Pironi
Loris
L
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002176:Candida albicans / Q000254:growth & development / Q000378:metabolism; D002908:Chronic Disease; D019422:Dietary Sucrose / Q000009:adverse effects; D000431:Ethanol / Q000097:blood*; D005285:Fermentation; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000378:metabolism* / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology*; D008297:Male; D016331:Parenteral Nutrition, Home
D000900:Anti-Bacterial Agents; D019422:Dietary Sucrose; D000431:Ethanol