A breast cancer patient with myelodysplastic syndrome postoperatively treated by radiation and tamoxifen administration--a case report.
A 72-year-old female developed pancytopenia 4 years after breast cancer surgery. She had received regional radiation postoperatively, and tamoxifen for 4 years. Bone marrow examination demonstrated immature myeloblasts and dysplastic cells. Myelodysplastic syndrome (MDS) of refractory anemia with excess blasts (RAEB) was diagnosed, and the patient died of cerebral hemorrhage 4 months after the diagnosis of RAEB. Radiation and the administration of tamoxifen were suspected to have played a role in the development of secondary MDS.
Mitani
Noriyuki
N
Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center, 77 Hofu city Ohsaki, Yamaguchi 747-8511, Japan.
Sakuragi
Schizu
S
Matsuda
Kazuhiro
K
Tanaka
Yoshinori
Y
Matsui
Kumiko
K
Shinohara
Kenji
K
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000209:etiology*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology; D005260:Female; D006801:Humans; D008408:Mastectomy; D011878:Radiotherapy / Q000009:adverse effects*; D013629:Tamoxifen / Q000009:adverse effects*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen