title: Bisphosphonate-induced osteonecrosis of the jaws: a case report and literature review.
abstract: Bisphosphonates are nonmetabolized analogues of pyrophosphate that are used for treating skeletal complications secondary to bone metastases. These drugs are capable of localizing to bone and inhibiting osteoclastic activity; however, their exact mechanisms of action remain unclear. Recently, it has been documented that administration of bisphosphonates has been associated with osteonecrosis of the jaws. This article details the case of a woman who received intravenous administration of bisphosphonate for metastatic breast cancer and subsequently developed osteonecrosis in both the maxillary and mandibular jaws.
authors.affiliation: Department of Dentistry, Jersey Shore University Medical Center, Neptune, USA.
authors.forename: Wellington S
authors.initials: WS
authors.lastname: Tsai
authors.forename: Kayvon
authors.initials: K
authors.lastname: Haghighi
authors.forename: Sally-Jo
authors.initials: SJ
authors.lastname: Placa
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D002710:Chlorhexidine / Q000627:therapeutic use; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008336:Mandibular Diseases / Q000139:chemically induced*; D008439:Maxillary Diseases / Q000139:chemically induced*; D008443:Maxillary Sinus / Q000187:drug effects; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D010254:Paranasal Sinus Diseases / Q000139:chemically induced; D010404:Penicillin V / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D002710:Chlorhexidine; D010404:Penicillin V