Endocrine and immunological alterations during cancer processes.
An immunological deficit is often associated with cancer processes. Because cortisol has an important immunosuppressive activity and it is strictly involved in stress responses, we examined its serum levels in colorectal cancer patients and its relationships with peripheral lymphocyte counts. Cortisol circadian rhythm and total and CD4+ lymphocytes were determined in 40 patients. The rate of patients with an altered cortisol circadian rhythm was 28%, and it was significantly more frequent in patients with nodal involvement (P < 0.005) and with metastatic spread (P < 0.005). Patient ratio with total lymphocytes assessment decrease was 30%. There was no correlation between lymphocytopenia and alteration of cortisol circadian rhythm. Data suggest a significant adrenal glands rhythm modification during cancer processes, associated with poor prognostic factors. Cortisol levels and lymphocytopenia seem not to be related. The origins of these alterations are unknown. They may favor or result from cancer spread.
Mussi
Chiara
C
Department of Surgery, University of Milan-Bicocca, San Gerardo Hospital, Monza, Italy. chiaramussi@yahoo.it
Crippa
Stefano
S
Bonardi
Claudia
C
Fontana
Alberto
A
Caprotti
Roberto
R
Uggeri
Franco
F
D000311:Adrenal Glands / Q000503:physiopathology; D000368:Aged; D018791:CD4 Lymphocyte Count; D002940:Circadian Rhythm; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D018655:Lymphocyte Count; D008297:Male; D009362:Neoplasm Metastasis
D006854:Hydrocortisone