Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis.
Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhance the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at 37 degrees C using a Franz diffusion cell, and the ultrasound treatment was carried out for 10 h. The level of TA permeation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, 2.5 W/cm2), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.
Yang
Jae-Heon
JH
Department of Pharmacy, Woosuk University, Samrye 565-701, Korea.
Kim
Dae-Keun
DK
Yun
Mi-Young
MY
Kim
Tae-Youl
TY
Shin
Sang-Chul
SC
D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005782:Gels; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability; D015612:Phonophoresis / Q000379:methods*; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D012869:Skin Absorption; D012995:Solubility; D013696:Temperature; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000893:Anti-Inflammatory Agents; D005782:Gels; D014222:Triamcinolone Acetonide