title: [Protective activity of adsorbed D(a)PT vaccine with the acellular pertussis component and polyoxydonium].
abstract: The introduction of the immunomodulator polyoxidonium in an amount of 0.5 Mg/ml into adsorbed D(a)PT vaccine with the acellular pertussis component leads to the preservation of the protective activity of the pertusis component, diphtheria and tetanus toxoids, as well to the 4-time decrease of the content of adsorbent (aluminium hydroxide) from 2 to 0.5 mg/ml.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: I G
authors.initials: IG
authors.lastname: Bazhanova
authors.forename: N U
authors.initials: NU
authors.lastname: Mertsalova
authors.forename: A V
authors.initials: AV
authors.lastname: Poddubikov
authors.forename: E M
authors.initials: EM
authors.lastname: Zaĭtsev
authors.forename: E V
authors.initials: EV
authors.lastname: Ermolova
mesh_terms: D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000818:Animals; D004165:Diphtheria / Q000517:prevention & control*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007279:Injections, Subcutaneous; D051379:Mice; D009930:Organic Chemicals / Q000008:administration & dosage; D013742:Tetanus / Q000517:prevention & control*; D014611:Vaccination; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D009930:Organic Chemicals; C089921:polyoxydonium; D000536:Aluminum Hydroxide