Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model.
To examine the antiadhesive effect of an alginate solution following tendon surgery, unilateral subtotal laceration of the flexor digitorum communis tendon was created in one hind limb while the other side was left intact in 32 Japanese white rabbits. The lesion was coated with alginate solution in 16 animals and not coated in the other 16. Degree of adhesion formation was assessed histologically and biomechanically by measuring the flexion angle of the first toe when the flexor digitorum tendon was pulled with a specified force at 4 weeks postoperatively. When compared with the control group, the alginate-treated group demonstrated significantly greater toe flexion, with less scar tissue formation at the repair site. Histologically, complete tendon healing with longitudinal remodeling of collagen fibers was observed in the alginate-treated group, while a random pattern of fibers was observed in the control group. Reduction in adhesion formation using alginate solution represents a novel strategy for the management of tendon injury and repair in the clinical setting.
Namba
Jiro
J
Department of Orthopaedic Surgery, Minoh City Hospital, 5-7-1, Kayano, Minoh, Osaka 562-0014, Japan. yonamba@ybb.ne.jp
Shimada
Kozo
K
Saito
Masanobu
M
Murase
Tsuyoshi
T
Yamada
Hideaki
H
Yoshikawa
Hideki
H
D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002921:Cicatrix / Q000188:drug therapy*; D004195:Disease Models, Animal; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D011817:Rabbits; D013708:Tendon Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013710:Tendons / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects*
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020723:Glucuronic Acid