PI3-kinase and the control of T cell growth and proliferation by FoxOs.
Numerous cancers are caused by an uncontrolled uncontrolled activity of the PI3-kinase pathway. The proto-oncogene Akt, one of its main effectors, commands several molecular switches involved in cell survival and proliferation. One of these switches is represented by a group of related molecules belonging to the Forkhead family of transcription factors, called FoxOs. FoxOs negatively control cell cycle entry and this process emerges now as a mainstream mechanism used by various cell types to escape cell quiescence. In the light of recent works, FoxOs seem also to have a key role in the proliferative response of immune cells, especially in the clonal expansion of T lymphocytes induced by antigen. Experimental evidence supporting a relationship in T cells between PI3-kinase metabolism and these growth suppressive genes will be described in this mini-review.
Fabre
Stéphanie
S
Institut Cochin, Départment de biologie cellulaire, Inserm U567, CNRS UMR8104. Université René-Descartes, équipe labellisée par la Ligne nationale contre le cancer, 22 rue Méchain, 75014 Paris. fabre@cochin.inserm.fr
Lang
Valérie
V
Bismuth
Georges
G
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D003593:Cytoplasm / Q000378:metabolism; D004789:Enzyme Activation; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010766:Phosphorylation; D000090063:Proto-Oncogene Mas; D013601:T-Lymphocytes / Q000502:physiology*
D051858:Forkhead Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D000090063:Proto-Oncogene Mas; C000715470:MAS1 protein, human