title: Human papillomavirus-16 in oral squamous cell carcinoma: clinical correlates and 5-year survival.
abstract: We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.
authors.affiliation: Department of Oral Health Research, School for Oral Health Science, Hiroshima University Faculty of Dentistry, Japan. masaru@hiroshima-u.ac.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Ujjal Kumar
authors.initials: UK
authors.lastname: Bhawal
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawamura
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Ishioka
authors.forename: Hideo
authors.initials: H
authors.lastname: Shigeishi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Higashikawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kamata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000821:virology*; D030361:Papillomavirus Infections / Q000401:mortality*; D016016:Proportional Hazards Models
chemical_list: D004279:DNA, Viral