Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection.
An advanced hyper-spectral imaging (HSI) system has been developed having obvious applications for cancer detection. This HSI system is based on state-of-the-art liquid crystal tunable filter technology coupled to an endoscope. The goal of this unique HSI technology being developed is to obtain spatially resolved images of the slight differences in luminescent properties of malignant versus non-malignant tissues. In this report, the development of the instrument is discussed and the capability of the instrument is demonstrated by observing mouse carcinomas in-vivo. It is shown that the instrument successfully distinguishes between normal and malignant mouse skin. It is hoped that the results of this study will lead to advances in the optical diagnosis of cancer in humans.
Martin
Matthew E
ME
Center for Advanced Biomedical Phoronics, Life Sciences Division, Oak Ridge National Laboratory, Tennessee, 37831-6101, USA.
Wabuyele
Musundi B
MB
Chen
Kui
K
Kasili
Paul
P
Panjehpour
Masoud
M
Phan
Mary
M
Overholt
Bergein
B
Cunningham
Glenn
G
Wilson
Dale
D
Denovo
Robert C
RC
Vo-Dinh
Tuan
T
D000818:Animals; D045744:Cell Line, Tumor; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D014134:Tracheal Neoplasms / Q000175:diagnosis*