title: A case of diabetic amyotrophy with severe atrophy and weakness of shoulder girdle muscles showing good response to intravenous immune globulin.
abstract: A 45-year-old man with insulin-dependent diabetic mellitus developed progressive asymmetrical weakness and atrophy of both shoulder girdle muscles within 1 year. In the last month, he also developed slight weakness of both thighs. Neuropathology of the sural nerve showed an axonal degeneration and perivascular inflammation and electromyography revealed neurogenic changes. Because of a diagnosis of suspected diabetic amyotrophy, intravenous immunoglobulin was administered. This treatment produced marked improvement. Physicians should take into account the possibility of diabetic amyotrophy in patients with diabetic mellitus showing primary involvement of shoulder girdle muscles marked by weakness and atrophy.
authors.affiliation: Department of Neurology, Nishi-Kobe Medical Center, Hyogo, Japan. wada@nmc-kobe.org
authors.forename: Yuko
authors.initials: Y
authors.lastname: Wada
authors.forename: Chie
authors.initials: C
authors.lastname: Yanagihara
authors.forename: Yo
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Oka
mesh_terms: D001284:Atrophy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003929:Diabetic Neuropathies / Q000150:complications* / Q000188:drug therapy*; D018450:Disease Progression; D007839:Functional Laterality; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018908:Muscle Weakness / Q000150:complications* / Q000188:drug therapy*; D018482:Muscle, Skeletal / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors