title: Phytoestrogens from Aspalathus linearis.
abstract: From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimamura
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Kaoru
authors.initials: K
authors.lastname: Umehara
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Warashina
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
mesh_terms: D036903:Aspalathus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D048789:Phytoestrogens / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D048789:Phytoestrogens; D004958:Estradiol