title: [The influence of hypocaloric diet on thrombocyte rheology in patients with metabolic syndrome].
abstract: The purpose of the study was to investigate the effects of hypocaloric diet (HCD) on intravascular thrombocyte activity (ITA) dynamics in patients with arterial hypertension (AH), androidal type of obesity, and glucose tolerance disorder. The subjects were 25 middle age patients with AH with metabolic syndrome (MS). Anthropometric variables, plasmatic lipid indices, as well as the intensity of lipid peroxidation in blood plasma and thrombocytes, were measured and evaluated. The patients' condition was being corrected using HCD during 24 weeks. The use of HCD in patients suffering from AH with metabolic syndrome favored lowering of the blood lipid spectrum shifts, suppression of peroxidation syndrome, and improvement of plasmatic and thrombocyte parameters. HCD lowered ITA, which was especially prominent by the end of the 24th week, but the control values were not reached. HCD in not effective enough as a sole method of correcting metabolic processes and ITA in patients suffering from AH with MS. Other therapeutic approaches to treatment of such patients should be searched.
authors.forename: I N
authors.initials: IN
authors.lastname: Medvedev
authors.forename: N I
authors.initials: NI
authors.lastname: Gromnatskiĭ
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012212:Rheology