title: [Back pain].
abstract: Low back pain created a dramatic increase in sick leave from 1970-95 despite of no pain-relevant biological changes of the back. An update of several disc-related pathologies is presented. Especially discovering the significance of Modic changes and a new muscle-function understanding contribute to a modernized view on pain mechanisms. Generally, traditional treatment modalities have an effect wise sparse influence on natural history over time. Subgroup identification is a central issue in modern research, because the effect of treatment can be very different across such groups.
authors.affiliation: Syddansk Universitet, RygForskningsCentret, Clinical Locomotion Science og Rygcenter Fyn. tbendix@health.sdu.dk
authors.forename: Tom
authors.initials: T
authors.lastname: Bendix
authors.forename: Claus
authors.initials: C
authors.lastname: Manniche
mesh_terms: D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000473:pathology; D017116:Low Back Pain / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D013130:Spinal Stenosis / Q000150:complications