title: Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection.
abstract: An advanced hyper-spectral imaging (HSI) system has been developed having obvious applications for cancer detection. This HSI system is based on state-of-the-art liquid crystal tunable filter technology coupled to an endoscope. The goal of this unique HSI technology being developed is to obtain spatially resolved images of the slight differences in luminescent properties of malignant versus non-malignant tissues. In this report, the development of the instrument is discussed and the capability of the instrument is demonstrated by observing mouse carcinomas in-vivo. It is shown that the instrument successfully distinguishes between normal and malignant mouse skin. It is hoped that the results of this study will lead to advances in the optical diagnosis of cancer in humans.
authors.affiliation: Center for Advanced Biomedical Phoronics, Life Sciences Division, Oak Ridge National Laboratory, Tennessee, 37831-6101, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Martin
authors.forename: Musundi B
authors.initials: MB
authors.lastname: Wabuyele
authors.forename: Kui
authors.initials: K
authors.lastname: Chen
authors.forename: Paul
authors.initials: P
authors.lastname: Kasili
authors.forename: Masoud
authors.initials: M
authors.lastname: Panjehpour
authors.forename: Mary
authors.initials: M
authors.lastname: Phan
authors.forename: Bergein
authors.initials: B
authors.lastname: Overholt
authors.forename: Glenn
authors.initials: G
authors.lastname: Cunningham
authors.forename: Dale
authors.initials: D
authors.lastname: Wilson
authors.forename: Robert C
authors.initials: RC
authors.lastname: Denovo
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D014134:Tracheal Neoplasms / Q000175:diagnosis*