title: Indocyanine green angiographic features of myopic subfoveal choroidal neovascularization as a prognostic factor after photodynamic therapy.
abstract: OBJECTIVE
  To determine the influence of clinical features and Indocyanine green (ICG) angiographic features on the visual outcome of patients with myopic sub-foveal choroidal neovascularization (CNV) who received photodynamic therapy (PDT).
  
  
  METHODS
  Thirty-six consecutive patients (39 eyes) with myopic CNV who were followed up for more than one year after PDT were enrolled in this study. Clinical features included age, gender, refractive error, great linear dimension, and subretinal hemorrhage. ICG features included the lesion size, lacquer cracks, hypofluorescence surrounding the CNV (dark rim), peripapillary atrophy size, and visible prominent choroidal veins under the macula. Linear regression analysis was performed using the change in visual acuity (delta logMAR) as the dependent variable and the above factors as independent variables.
  
  
  RESULTS
  At one-year follow-up after PDT, a younger age (p = 0.002) and the presence of a dark rim (p = 0.002) were significantly correlated with an improvement of visual acuity (decrement in logMAR) after PDT. Other factors had no significant influence on changes in visual acuity.
  
  
  CONCLUSIONS
  Younger patients and patients with a dark rim on ICG angiography had a higher chance of visual improvement after PDT in myopic CNV.
authors.affiliation: Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Suk Ho
authors.initials: SH
authors.lastname: Byeon
authors.forename: Oh Woong
authors.initials: OW
authors.lastname: Kwon
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Lee
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hyoung Jun
authors.initials: HJ
authors.lastname: Koh
mesh_terms: D000328:Adult; D000368:Aged; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000473:pathology; D010778:Photochemotherapy; D011379:Prognosis; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green