title: Human immunodeficiency virus and the central nervous system.
abstract: The pandemic of HIV/AIDS continues to grow daily. Incident cases among women, intravenous drug users and ethnic minorities comprise the fastest growing segment of the HIV-infected population, and the number of HIV-infected individuals over the age of 50 is growing rapidly. Today, the central nervous system and the immune system are seen as main targets of HIV infection. Significant progress in the knowledge and treatment of AIDS has been obtained in recent years. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system.
authors.affiliation: Neurology Unit, Universidade Federal do Paraná, Curitiba, PR, Brazil. sdealmeida@ucsd.edu
authors.forename: Sergio Monteiro
authors.initials: SM
authors.lastname: de Almeida
authors.forename: Scott
authors.initials: S
authors.lastname: Letendre
authors.forename: Ron
authors.initials: R
authors.lastname: Ellis
mesh_terms: D000386:AIDS-Related Complex / Q000188:drug therapy / Q000821:virology; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D020805:Central Nervous System Viral Diseases / Q000188:drug therapy / Q000378:metabolism / Q000821:virology*; D018925:Chemokines / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015497:HIV-1; D006801:Humans; D008587:Meningitis, Viral / Q000821:virology; D008875:Middle Aged; D012307:Risk Factors; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D018925:Chemokines