title: Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial.
abstract: BACKGROUND
  High-quality cardiopulmonary resuscitation (CPR) may improve both cardiac and brain resuscitation following cardiac arrest. Compared with manual chest compression, an automated load-distributing band (LDB) chest compression device produces greater blood flow to vital organs and may improve resuscitation outcomes.
  
  
  OBJECTIVE
  To compare resuscitation outcomes following out-of-hospital cardiac arrest when an automated LDB-CPR device was added to standard emergency medical services (EMS) care with manual CPR.
  
  
  METHODS
  Multicenter, randomized trial of patients experiencing out-of-hospital cardiac arrest in the United States and Canada. The a priori primary population was patients with cardiac arrest that was presumed to be of cardiac origin and that had occurred prior to the arrival of EMS personnel. Initial study enrollment varied by site, ranging from late July to mid November 2004; all sites halted study enrollment on March 31, 2005.
  
  
  METHODS
  Standard EMS care for cardiac arrest with an LDB-CPR device (n = 554) or manual CPR (n = 517).
  
  
  METHODS
  The primary end point was survival to 4 hours after the 911 call. Secondary end points were survival to hospital discharge and neurological status among survivors.
  
  
  RESULTS
  Following the first planned interim monitoring conducted by an independent data and safety monitoring board, study enrollment was terminated. No difference existed in the primary end point of survival to 4 hours between the manual CPR group and the LDB-CPR group overall (N = 1071; 29.5% vs 28.5%; P = .74) or among the primary study population (n = 767; 24.7% vs 26.4%, respectively; P = .62). However, among the primary population, survival to hospital discharge was 9.9% in the manual CPR group and 5.8% in the LDB-CPR group (P = .06, adjusted for covariates and clustering). A cerebral performance category of 1 or 2 at hospital discharge was recorded in 7.5% of patients in the manual CPR group and in 3.1% of the LDB-CPR group (P = .006).
  
  
  CONCLUSIONS
  Use of an automated LDB-CPR device as implemented in this study was associated with worse neurological outcomes and a trend toward worse survival than manual CPR. Device design or implementation strategies require further evaluation.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00120965.
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA 98105, USA. aph@u.washington.edu
authors.forename: Al
authors.initials: A
authors.lastname: Hallstrom
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Rea
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sayre
authors.forename: James
authors.initials: J
authors.lastname: Christenson
authors.forename: Andy R
authors.initials: AR
authors.lastname: Anton
authors.forename: Vince N
authors.initials: VN
authors.lastname: Mosesso
authors.forename: Lois
authors.initials: L
authors.lastname: Van Ottingham
authors.forename: Michele
authors.initials: M
authors.lastname: Olsufka
authors.forename: Sarah
authors.initials: S
authors.lastname: Pennington
authors.forename: Lynn J
authors.initials: LJ
authors.lastname: White
authors.forename: Stephen
authors.initials: S
authors.lastname: Yahn
authors.forename: James
authors.initials: J
authors.lastname: Husar
authors.forename: Mary F
authors.initials: MF
authors.lastname: Morris
authors.forename: Leonard A
authors.initials: LA
authors.lastname: Cobb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation* / Q000379:methods*; D004632:Emergency Medical Services; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis