[Allergenic and immunotropic properties of yeast RNA-tilorone hydrochloride molecular complex].
Immunotropic properties of the interferon-inducing molecular complex (MC) yeast RNA--tilorone hydrochloride have been under study. MC was experimentally studied in vivo to establish its influence on the amount of antibody-forming cells and the level of antibody formation. The influence of MC on the oxygen-generating activity of spleen macrophages was established in the HCT test. MC in a dose of 1.25 mg/kg was shown to considerably activate immunocompetent cells, thus producing pronounced influence on humoral immunity. In addition, the study showed the dose dependence of the influence of MC on individual elements of the immune system as well as differences in the dynamics of immunomodulation caused by the use of high and low doses of MC. The data thus obtained made it possible to regard MC as a promising immunomodulator.
Tkachenko
I V
IV
Garkavaia
E G
EG
Karpov
A V
AV
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D000921:Antibody-Producing Cells / Q000166:cytology; D002452:Cell Count; D004306:Dose-Response Relationship, Immunologic; D015536:Down-Regulation; D004338:Drug Combinations; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007274:Injections, Intraperitoneal; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010100:Oxygen / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology; D012331:RNA, Fungal / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D013994:Tilorone / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D013997:Time Factors; D015854:Up-Regulation
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D012331:RNA, Fungal; D013994:Tilorone; D010100:Oxygen