Role of integrins in peripheral nerves and hereditary neuropathies.
Interactions between Schwann cells and extracellular matrix on one surface, and axons on the other, are required for correct myelination in the developing peripheral nervous system. Integrins are transmembrane proteins that mediate the former in association with other surface receptors. This review focuses on the role that integrins play in the development of the peripheral nervous system, and in inherited human peripheral neuropathies. Here we describe recent findings on integrin signaling to different intracellular pathways, focusing on cell adhesion, migration, and polarization. Then we use information derived from recent experiments of targeted mutagenesis in mice to show that, consistent with temporally regulated expression, different integrins serve multiple roles in developing nerve.
Berti
Caterina
C
San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milano, Italy.
Nodari
Alessandro
A
Wrabetz
Lawrence
L
Feltri
Maria Laura
ML
D000818:Animals; D019070:Cell Lineage; D016764:Cell Polarity; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D007797:Laminin / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology; D010525:Peripheral Nerves / Q000166:cytology / Q000378:metabolism* / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D016023:Integrins; D007797:Laminin; D020033:Protein Isoforms