Role of complement component C5 in cerebral ischemia/reperfusion injury.
We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic C5 inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury.
Costa
Cristina
C
Department of Preclinical Sciences, Alexion Pharmaceuticals Inc., Cheshire, CT 06410, USA. ccosta@iro.es
Zhao
Limin
L
Shen
Yamin
Y
Su
Xiao
X
Hao
Liming
L
Colgan
Sean P
SP
Stahl
Gregory L
GL
Zhou
Tong
T
Wang
Yi
Y
D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001929:Brain Edema / Q000473:pathology; D002545:Brain Ischemia / Q000473:pathology*; D050577:Complement C3-C5 Convertases / Q000037:antagonists & inhibitors; D003182:Complement C5 / Q000502:physiology*; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*
D019138:Antibodies, Blocking; D000911:Antibodies, Monoclonal; D003182:Complement C5; D018836:Inflammation Mediators; D050577:Complement C3-C5 Convertases