[Study of chemical constituents in stem rind of Daphne giraldii].
OBJECTIVE
To study the constituents with the pain-relieving activity from the stem rind of Daphne giraldii.


METHODS
The partition of the ethanol extract and chromatographic separation of the fractions were carried out by the monitoring of anelgesic pharmacological activity. The structures of the isolated compounds were determined by MS and NMR.


RESULTS
Four compounds were isolated from the pain-relieving fraction. Three of them were identified as diterpenes, gniditrin (1), gnidicin (2) and daphnetoxin (3). Compound 4 was determined as Z-octadecyl caffeate.


CONCLUSIONS
Compounds 1, 2 and 4 were isolated from the plant for the first time.
Zhou
Guang-Xiong
GX
College of Pharmacy, Jinan University, Guangzhou 510632, China.
Yang
Yong-Chun
YC
Shi
Jian-Gong
JG
D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032364:Daphne / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000700:Analgesics; D002109:Caffeic Acids; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; C517789:octadecyl caffeate; C452759:daphnetoxin; C010461:gniditrin; C010459:gnidicin