title: Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease.
abstract: We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 mumol/l increment was associated with a 25% higher risk.
authors.affiliation: Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel. motih@netvision.net.il
authors.forename: Moti
authors.initials: M
authors.lastname: Haim
authors.forename: David
authors.initials: D
authors.lastname: Tanne
authors.forename: Uri
authors.initials: U
authors.lastname: Goldbourt
authors.forename: Ram
authors.initials: R
authors.lastname: Doolman
authors.forename: Valentina
authors.initials: V
authors.lastname: Boyko
authors.forename: Daniel
authors.initials: D
authors.lastname: Brunner
authors.forename: Ben-Ami
authors.initials: BA
authors.lastname: Sela
authors.forename: Solomon
authors.initials: S
authors.lastname: Behar
mesh_terms: D001629:Bezafibrate / Q000627:therapeutic use; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood*; D016757:Death, Sudden, Cardiac; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000517:prevention & control; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000960:Hypolipidemic Agents; D006710:Homocysteine; D001629:Bezafibrate