title: Diffusion-weighted MR imaging lesions after filter-protected stenting of high-grade symptomatic carotid artery stenoses.
abstract: OBJECTIVE
  The clinical efficacy of filter devices in internal carotid artery (ICA) stent placement has been a matter of controversy. The aim of this retrospective study was to assess the number and extent of cerebral emboli, as represented by new lesions on diffusion-weighted MR imaging (DWI), in patients treated with filter-protected carotid stent placement.
  
  
  METHODS
  Standard DWI (B0 = 1000) was performed within 48 hours before and 48 hours after filter-protected carotid stent placement in 50 patients with symptomatic, high grade (>70%), atherosclerotic ICA stenosis. Number, extent, and vascular territory of new DWI lesions after stent placement were assessed by consensus of 2 experienced neuroradiologists. Multifactorial statistical analysis was performed to determine risk factors associated with DWI lesions.
  
  
  RESULTS
  New punctate DWI lesions with a median diameter of 2 mm were detected in 14 of 50 cases in the territory of the stented ICA and in 7 of 50 cases in other vascular territories. Median lesion load was 1 lesion (range, 1-15) per positive case in the stented ICA and 1 lesion (range, 1-7) in other vascular territories. All DWI lesions were clinically asymptomatic. Because of 1 hyperperfusion syndrome with temporary brain swelling, the 30-day stroke and death rate was 2%. Age >or =70 years was the only significant predictor for new DWI lesions, whereas sex, degree and site of stenosis, vascular risk factors, and stent and filter type showed no significant correlation.
  
  
  CONCLUSIONS
  New DWI lesions after filter-protected carotid stent placement are substantially more frequent in the ipsilateral ICA territory compared with other vascular territories. Therefore, intraluminal filters cannot completely protect the brain from procedure-related embolization. However, individual lesion load and the risk of clinically relevant ischemia is low.
authors.affiliation: Institute of Neuroradiology, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt/Main, Schleusenweg 2-16, 60-528 Frankfurt am Main, Germany.
authors.forename: R
authors.initials: R
authors.lastname: du Mesnil de Rochemont
authors.forename: S
authors.initials: S
authors.lastname: Schneider
authors.forename: B
authors.initials: B
authors.lastname: Yan
authors.forename: A
authors.initials: A
authors.lastname: Lehr
authors.forename: M
authors.initials: M
authors.lastname: Sitzer
authors.forename: J
authors.initials: J
authors.lastname: Berkefeld
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications / Q000601:surgery*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D020766:Intracranial Embolism / Q000175:diagnosis* / Q000517:prevention & control; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D015607:Stents / Q000009:adverse effects