Pre-T cell receptor's clashing signals: "should I stay or should I go".
In this issue of Immunity, Kersh and colleagues (Xi et al., 2006) investigate the regulatory network that permits two otherwise clashing cellular processes--proliferation and gene rearrangement--to occur at temporally distinct periods following the formation of the pre-T cell receptor (pre-TCR) complex.
Zúñiga-Pflücker
Juan Carlos
JC
Sunnybrook Research Institute, Department of Immunology, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address: jczp@sri.utoronto.ca.
Ciofani
Maria
M
Sunnybrook Research Institute, Department of Immunology, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
D000818:Animals; D008213:Lymphocyte Activation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta