title: Absorption, disposition and excretion of polybrominated diphenyl ethers (PBDEs) in chicken.
abstract: Except for fish, no toxicokinetic data on polybrominated diphenyl ethers (PBDEs) is available on relevant animals for the human food chain. In the present work, absorption, elimination through eggs and disposition of PBDEs in laying chickens were studied and compared to dioxin behaviour. Hens were fed with diet containing 3.4 mg/kg feed of PBDEs and 0.95 ng TEQ/kg feed of polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs). PBDEs have been demonstrated to show drastically different behaviours from PCDD/Fs and dioxin-like compounds. Excretion of PBDEs increased for two weeks and then decreased to nearly 0%. Sixty-two percent of ingested 2,2',4,4'-tetraBDE (BDE-47) were found in excreta after two weeks, suggesting a reductive debromination of PBDEs in the digestive tract. PBDE level in eggs increased during five weeks and reached 24 microg/g fat. After then, levels decreased to 3 microg/g fat at the end of the trial. PBDE bioconcentration factors estimated for abdominal fat varied from 0.7 for BDE-47 to 2 for BDE-183.
authors.affiliation: CART Mass Spectrometry Laboratory, Chemistry Department, University of Liège, Allée de la Chimie 3, B-6c, B-4000 Liège, Belgium. Catherine.Pirard@ulg.ac.be
authors.forename: Catherine
authors.initials: C
authors.lastname: Pirard
authors.forename: Edwin
authors.initials: E
authors.lastname: De Pauw
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D005260:Female; D055768:Halogenated Diphenyl Ethers; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D011075:Polybrominated Biphenyls / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C086401:pentabromodiphenyl ether