title: [Structural and functional organization of hepatitis C virus genome].
abstract: The review gives recent data on the structure of hepatitis C virus genome. Linear RNA comprises one translated and two nontranslated regions: 5'UTR and 3'UTR. Translation of viral RNA gives rise to a single polyprotein precursor that contains structural and nonstructural regions. The structural region comprises one nucleocapsid core-protein and two envelope proteins known as E1 and E2. E2 protein includes two hypervariable regions: HVR1 and HVR2. The nonstructural region consists of 7 proteins: p7 (NS1), NS (metalloproteinase), NS (serine protease/ helicase), NS4A (co-factor protease, co-factor RNA-dependent RNA polymerase), and NS4B, NS5A, NS5B (RNA-dependent RNA polymerase). NS5A includes ISDR (interferon-sensitivity-determining region).
authors.forename: N V
authors.initials: NV
authors.lastname: Dunaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Esaulenko
mesh_terms: D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D022801:Complementarity Determining Regions; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics* / Q000502:physiology; D007372:Interferons / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins; D045726:Metalloproteases / Q000235:genetics / Q000502:physiology; D019251:Nucleocapsid; D020815:Polyproteins / Q000235:genetics / Q000502:physiology; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics / Q000502:physiology; D020506:Untranslated Regions; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology; D014779:Virus Replication; D000086082:Viroporin Proteins
chemical_list: D002352:Carrier Proteins; D022801:Complementarity Determining Regions; D007372:Interferons; D047908:Intracellular Signaling Peptides and Proteins; D045726:Metalloproteases; D020815:Polyproteins; D011498:Protein Precursors; D012367:RNA, Viral; D012324:RNA-Dependent RNA Polymerase; D012697:Serine Endopeptidases; D020506:Untranslated Regions; D014759:Viral Envelope Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C455041:NS4A cofactor peptide, Hepatitis C virus; C088369:p7 protein, Hepatitis C virus; D000086082:Viroporin Proteins; C087036:NS-5 protein, hepatitis C virus