title: Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation.
abstract: From the cultured cells of Panax notoginseng, a kind of ginseng saponin-ginsenoside Rg2, was separated and purified, and its structure was elucidated as 6-O-[alpha-L-rhamnose (l-->2)-beta-D-glucopyranosyl]3beta, 12beta, 20(S)-trihydroxydammar-24-ene [20(S)-ginsenoside Rg2]. Moreover, its bioactivity stimulates human umbilical cord vein endothelial cell proliferation; the growth of the cells treated with 20(S)-ginsenoside Rg2 was 14-fold higher than that of untreated ones, and the level of the cell's plasminogen activator (PA) was also twofold higher.
authors.affiliation: State Key laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, P.R. China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Xin
authors.forename: Jianwen
authors.initials: J
authors.lastname: Liu
authors.forename: Xiqiang
authors.initials: X
authors.lastname: Li
authors.forename: Jianjiang
authors.initials: J
authors.lastname: Zhong
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Wei
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects*; D036145:Ginsenosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D005894:Panax; D010960:Plasminogen Activators / Q000187:drug effects*; D014470:Umbilical Cord / Q000187:drug effects
chemical_list: D036145:Ginsenosides; C026474:ginsenoside Rg2; D010960:Plasminogen Activators