SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis.
OBJECTIVE
To explore the role of single nuclear polymorphisms (SNP) in 2 candidate genes, SUMO4 and MAP3K7IP2, in susceptibility to rheumatoid arthritis (RA).


METHODS
Two cohorts from different Spanish towns totalling 635 patients with RA and 826 controls were studied. Six SNP were genotyped by matrix assisted laser desorption-ionization time-of-flight (MALDI-TOF) with the MassARRAY SNP genotyping system.


RESULTS
We found no association with susceptibility to RA for any of the SNP including a previously described functional variant in the SUMO4 gene (163A-->G). RA susceptibility was independent of the haplotypes defined by the 6 SNP and there was also no association with clinical features of RA. Conclusion. SUMO4 and MAP3K7IP2 SNP did not significantly influence predisposition to and features of RA, in contrast to previous genetic and functional evidence that suggested their involvement.
Costas
Javier
J
Research Laboratory 2, Rheumatology Unit, and National Genotyping Center, Hospital Clinco Universitario de Santiago, 15706 Santiago de Compostela, Spain.
Perez-Pampin
Eva
E
Ferreiros-Vidal
Isabel
I
Torres
Maria
M
Phillips
Christopher
C
Vicario
Jose Luis
JL
Pablos
Jose Luis
JL
Carracedo
Angel
A
Gomez-Reino
Juan J
JJ
Gonzalez
Antonio
A
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D048868:Adaptor Proteins, Signal Transducing; C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins; C410585:TAB2 protein, human