title: Measurements of exposure concentrations of benzene, toluene and xylene, and amounts of respiratory uptake.
abstract: With respect to benzene, toluene, and o-, m- and p-xylene contained in indoor air, this study determined the amounts of their uptake through the human respiratory system using the difference between concentrations in inhalation and exhalation, and examined their relationship to concentrations in blood and urine measured before and after exposure. At relatively high concentrations, respiratory absorption of these compounds tended to increase rapidly in the early stage of exposure but decrease after several hours. It was also confirmed that concentrations of these compounds in both blood and urine increased during the first 3 hours of exposure. These results suggested that measurements of concentrations in inhalation and exhalation may provide a simple method for estimating the extent of respiratory exposure to these substances.
authors.affiliation: Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Murayama
authors.forename: Sumio
authors.initials: S
authors.lastname: Goto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakajima
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Fujimaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Watanabe
authors.forename: Keiichi
authors.initials: K
authors.lastname: Arashidani
authors.forename: Iwao
authors.initials: I
authors.lastname: Uchiyama
mesh_terms: D000042:Absorption; D000393:Air Pollutants / Q000097:blood / Q000652:urine; D016902:Air Pollution, Indoor / Q000032:analysis*; D001554:Benzene / Q000032:analysis / Q000493:pharmacokinetics*; D004784:Environmental Monitoring / Q000379:methods; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D008875:Middle Aged; D012137:Respiratory System / Q000378:metabolism*; D014050:Toluene / Q000032:analysis / Q000493:pharmacokinetics*; D014992:Xylenes / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D000393:Air Pollutants; D014992:Xylenes; D014050:Toluene; D001554:Benzene