title: Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation.
abstract: The main objective of this retrospective study was to investigate relations between cyclin E and pathoclinical factors in patients with operable breast cancer. Expression of cyclin E was analyzed by immunohistochemistry in specimens of invasive ductal breast cancer tissue obtained from 189 women during radical mastectomy. Overall, 110 tumor samples were regarded to be cyclin E positive. Cyclin E expression was more often seen in tumors with: negative steroid receptor status (p<0.0001), higher proliferative index (p=0.0014), higher tumor grade (p=0.0017), and presence of HER2 (p=0.0171). With a median follow-up of 58 months, expression of cyclin E together with negative steroid receptor status determined poor prognosis with a 5-year cancer-specific survival rate of 58%. It differed significantly from a survival curve of cyclin E negative and steroid receptor positive patients (87%, p=0.0005). No significant difference was observed in comparison with survival of cyclin E positive and steroid receptor positive patients (68%, p=0.221). We demonstrated that cyclin E expression in breast cancer cells was associated with negative steroid receptor status, HER2 presence, higher tumor grade and higher proliferation index. Expression of cyclin E together with lack of steroid receptors determined poor prognosis.
authors.affiliation: Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland. piotrpo@mp.pl
authors.forename: P
authors.initials: P
authors.lastname: Potemski
authors.forename: R
authors.initials: R
authors.lastname: Kusinska
authors.forename: C
authors.initials: C
authors.lastname: Watala
authors.forename: E
authors.initials: E
authors.lastname: Pluciennik
authors.forename: A K
authors.initials: AK
authors.lastname: Bednarek
authors.forename: R
authors.initials: R
authors.lastname: Kordek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D019927:Cyclin E / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D011987:Receptors, Steroid / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D019927:Cyclin E; D018719:Erb-b2 Receptor Tyrosine Kinases; D011987:Receptors, Steroid