Domino metal-free allene-beta-lactam-based access to functionalized pyrroles.
A novel transition metal-free domino reaction sequence in allene-beta-lactams, leading to the biologically relevant pyrrole frame has been developed using a sodium methoxide-methanol system.
Alcaide
Benito
B
Departamento de Química Orgánica, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid, Spain. alcaideb@quim.ucm.es
Almendros
Pedro
P
Redondo
María C
MC
D003500:Cyclization; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D047090:beta-Lactams / Q000737:chemistry*
D008670:Metals; D011758:Pyrroles; D047090:beta-Lactams