title: Block copolymer micelles as matrixes for incorporating diselenide compounds: a model system for a water-soluble glutathione peroxidase mimic fine-tuned by ionic strength.
abstract: We report on the use of block copolymer micelles of polystyrene-b-poly(acrylic acid) (PS-b-PAA) as matrixes for incorporating dibenzyl diselenide. We found that the water-insoluble diselenide, after being incorporated into the micelles, demonstrates glutathione peroxidase (GPx) activity in water. Surprisingly, the mimicking system can be adjusted to show higher GPx activity by increasing the ionic strength of the solution simply upon addition of NaCl. Moreover, dibenzyl diselenide incorporated into the micelles is quite stable and maintains its GPx activity even after exposure to the atmosphere.
authors.affiliation: Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Yapei
authors.initials: Y
authors.lastname: Wang
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
authors.forename: Jiacong
authors.initials: J
authors.lastname: Shen
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008854:Microscopy, Electron; D008956:Models, Chemical; D018716:Molecular Mimicry; D016566:Organoselenium Compounds / Q000737:chemistry*; D009994:Osmolar Concentration; D011137:Polystyrenes / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014867:Water
chemical_list: D000179:Acrylates; D001593:Benzyl Compounds; D008823:Micelles; D016566:Organoselenium Compounds; D011137:Polystyrenes; C509855:poly(styrene-b-acrylic acid); D014867:Water; C073177:dibenzyl diselenide; D005979:Glutathione Peroxidase