title: Risk for transient ischemic attacks is mainly determined by intima-media thickness and carotid plaque echogenicity.
abstract: BACKGROUND
  Stenosis severity, plaque morphology, and intima-media thickness (IMT), all have been found to provide prognostic information in patients with asymptomatic carotid artery disease. However, limited data exist on the association between these parameters and the risk for transient ischemic attack (TIA).
  
  
  METHODS
  We compared the ultrasonographic characteristics of 88 consecutive patients with first TIA without known cardioembolic source with those of 176 propensity-matched asymptomatic control subjects.
  
  
  RESULTS
  IMT was higher in TIA patients compared to control subjects (0.74+/-0.14 mm versus 0.68+/-0.13 mm, p=0.001). Plaques were found in 70.5% of patients and 64.8% of controls (p=0.407). Compared with controls, TIA patients demonstrated more frequently predominantly echolucent lesions (77.4% versus 56.1%, p=0.005) and high-grade carotid stenoses (21.0% versus 9.6%, p=0.042). TIA patients with low-to-moderate grade (<70%) lesions exhibited higher IMT and more prevalent echolucent morphology in comparison with their control counterparts. No significant differences were observed between groups regarding high-grade lesions. In multivariate models, IMT and plaque echogenicity, but not stenosis severity, emerged as independent determinants of risk.
  
  
  CONCLUSIONS
  Risk for TIA is primarily associated with IMT and plaque echogenicity, especially in the absence of high-grade lesions. Stenosis severity appears to be of limited prognostic value.
authors.affiliation: Division of Cardiology, University Hospital of Patras, Rion, Greece. egiondoc@otenet.gr
authors.forename: Andreas
authors.initials: A
authors.lastname: Kalogeropoulos
authors.forename: George
authors.initials: G
authors.lastname: Terzis
authors.forename: Athina
authors.initials: A
authors.lastname: Chrysanthopoulou
authors.forename: George
authors.initials: G
authors.lastname: Hahalis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Siablis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011859:Radiography; D012306:Risk; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography