Cellular orchestration of T cell priming in lymph nodes.
Progress made in visualizing T cell responses in vivo and at the single cell level has revealed an unexpected level of complexity in the orchestration of T cell activation in lymph nodes. The choreography that leads to the initiation of a T cell response involves multiple cellular actors, and is intrinsically influenced by their motility and their mode of cell-cell interactions. Recent studies have begun to depict the cellular orchestration of T cell priming and to analyze the way it could influence the outcome of T cell responses.
Breart
Béatrice
B
G5 Dynamiques des Réponses Immunes, Equipe Avenir, Inserm U668, Institut Pasteur, Paris, France.
Bousso
Philippe
P
D000818:Animals; D002450:Cell Communication / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*