Studies toward soraphen A: an aldol-metathesis avenue to the macrocyclic framework.
[reaction: see text] We describe a convergent approach to soraphen A, 1, that involves coupling of two fragments by an aldol condensation-olefin metathesis sequence. This route permits rapid access to congeners of 1.
Vincent
Guillaume
G
Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, Villeurbanne, France.
Mansfield
Darren J
DJ
Vors
Jean-Pierre
JP
Ciufolini
Marco A
MA
D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D018942:Macrolides; C086151:soraphen A