Hemophagocytic lymphohistiocytosis complicating influenza A infection.
During the influenza A (H3N2) season of 2003-2004, several influenza-related complications and deaths were reported in children. Hemophagocytic lymphohistiocytosis complicating influenza A infection is very rare. We report a 3-year-old girl who presented with severe pneumonia and hemophagocytic lymphohistiocytosis associated with influenza A infection. Clinicians should be aware of hemophagocytic syndrome as a serious complication of influenza A infection.
Mou
Steven S
SS
Department of Anesthesiology, Section on Pediatric Critical Care Medicine, Wake Forest University School of Medicine and Brenner Children's Hospital, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1009, USA. smou@wfubmc.edu
Nakagawa
Thomas A
TA
Riemer
Ellen C
EC
McLean
Thomas W
TW
Hines
Michael H
MH
Shetty
Avinash K
AK
D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000473:pathology / Q000628:therapy
D016756:Immunoglobulins, Intravenous