Isolation, structure determination and biological activity of a new glutarimide antibiotic, S632A3.
A new antibiotic, S632A3, was isolated from a cultured broth of Streptomyces hygroscopicus S632. It was purified by column chromatography on silica gel, Sephadex LH-20 and HPLC. Structural studies by analysis of 1H NMR and 13C NMR, MS, UV and IR spectra in comparison with those of S632A2 clarified that S632A3 is an isomer of 9-methylstreptimidone. In addition, this antibiotic showed potent biological activity including differentiation induction effects on HL-60 cell and antitumour activity in vivo.
Cheng
Chun-Lei
CL
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Liu
Qiong-Yan
QY
Chen
Li-Hui
LH
Jin
Wen-Zao
WZ
Si
Shu-Yi
SY
Li
Dian-Dong
DD
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010881:Piperidones; C511904:S632A3