title: Electrochemical characteristics of gatifloxacin and its interaction with DNA.
abstract: The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 x 10(5) (mol L(-1))(-1) and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit analysis of electrochemical data. The results demonstrate that GTFX has the properties of an intercalative binder.
authors.affiliation: Department of Chemistry, Zhejiang Forestry University, LinAn, China. tdky@hotmail.com
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.forename: Qing-Sen
authors.initials: QS
authors.lastname: Yu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001665:Binding Sites; D002244:Carbon; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D024841:Fluoroquinolones / Q000737:chemistry*; D000077734:Gatifloxacin; D008024:Ligands
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D008024:Ligands; D002244:Carbon; D004247:DNA; C427203:calf thymus DNA; D000077734:Gatifloxacin