Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis.
Three HIV-1-seronegative patients with disseminated tuberculosis presented significant depletion of T-cell counts, in CD4+ and/or CD8+ cells, associated with increased expression of activation marker CD38 on CD8+ T-lymphocytes. This finding raises the question of potential mechanisms involved in the activation or loss of T-cells in disseminated tuberculosis.
Rodrigues
Denise Silva
DS
Infectious Diseases Division, Federal University of São Paulo, São Paulo, SP, Brazil.
Salomão
Reinaldo
R
Kallas
Esper Georges
EG
D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology*; D000328:Adult; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology*
D051997:ADP-ribosyl Cyclase 1