Limbal stem cell deficiency after subconjunctival mitomycin C injection for trabeculectomy.
OBJECTIVE
To report on severe limbus cell insufficiency after trabeculectomy with subconjunctival injection of mitomycin C.


METHODS
Interventional small case-series.


METHODS
Seven consecutive Caucasian patients (seven eyes) underwent penetrating trabeculectomy that included subconjunctival injection of 0.1 to 0.2 ml of mitomycin C (0.2 mg/ml) at the 12 o'clock position.


RESULTS
All patients with a follow-up time of >1.5 years (n = 3 eyes; 43%) experienced marked ocular surface problems that included corneal thinning (n = 1) and scleral melting (n = 2). Four patients (57%) with a follow-up time of <14 months did not show complications that were attributable to the subconjunctival application of mitomycin.


CONCLUSIONS
Because limbal stem cell deficiency may be a late complication of subconjunctival mitomycin C injection, subconjunctival injection of mitomycin C may be avoided in routine antiglaucomatous filtering surgery.
Sauder
Gangolf
G
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de
Jonas
Jost B
JB
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003228:Conjunctiva; D003316:Corneal Diseases / Q000139:chemically induced*; D006801:Humans; D007267:Injections; D016850:Limbus Corneae / Q000187:drug effects* / Q000473:pathology; D016685:Mitomycin / Q000009:adverse effects*; D015422:Scleral Diseases / Q000139:chemically induced; D013234:Stem Cells / Q000187:drug effects* / Q000473:pathology; D014130:Trabeculectomy
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin