title: Drug eruption due to bosentan in a patient with systemic sclerosis.
abstract: We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Since the use of bosentan is expected to increase, we should be aware of the previously unknown adverse effects as well as skin eruptions.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, 371-8511, Japan. yanagai@showa.gunma-u.ac.jp
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamanaka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishimura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nakano
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D000077300:Bosentan; D003875:Drug Eruptions; D065128:Endothelin Receptor Antagonists; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012595:Scleroderma, Systemic / Q000150:complications; D013449:Sulfonamides / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D011239:Prednisolone; D000077300:Bosentan