Unresponsive or non-compliant steatorrhea in cystic fibrosis?
In 105 pancreatic insufficient CF patients (steatorrhea and low fecal elastase-1 concentrations), the effectiveness of pancreatic enzyme therapy (PET) has been assessed (fecal fat losses and coefficient of fat reabsorption). Eight unresponsive subjects were checked for PET compliance with fecal chymotrypsin assay. Three patients were documented to be non-compliant. Unresponsive patients should undergo evaluation for PET compliance.
Lisowska
Aleksandra
A
Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.
Kaminska
Barbara
B
Grzymislawski
Marian
M
Herzig
Karl-Heinz
KH
Walkowiak
Jaroslaw
J
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002918:Chymotrypsin / Q000032:analysis; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D008297:Male; D010196:Pancreatic Elastase / Q000032:analysis; D010186:Pancreatic Function Tests; D010349:Patient Compliance; D045602:Steatorrhea / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D016896:Treatment Outcome
D006867:Hydrolases; D002918:Chymotrypsin; D010196:Pancreatic Elastase