Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats.
OBJECTIVE
The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wine, in the rat after ischemia-reperfusion (I/R).


METHODS
The left coronary artery was in occlusion for 30 min followed by a 120 min reperfusion in anesthetized rats. Animals were pretreated with and without resveratrol before occlusion. The post-ischemic ventricular function (left ventricle maximum systolic pressures and the maximal first derivative of developed pressure) and myocardial infarct size and myocardial nitric oxide (NO) and malonaldehyde (MDA) content were compared.


RESULTS
Resveratrol pretreatment had dramatic cardioprotective effects on post-ischemic ventricular functional recovery and decreasing myocardial infarct size. Resveratrol pretreatment also increased NO and decreased MDA content in myocardium.


CONCLUSIONS
Resveratrol has cardioprotective properties in I/R rats. The cardioprotective effects in the I/R rats may be correlated with its antioxidant activity and upregulation of NO production.
Shen
Min
M
Medical Department of Cardiology, Xijing Hospital, the Fourth Military Medical University, No 15, Chang-Le West Road, xi'an, shaanxi, 710032, China. shen_348@hotmail.com
Jia
Guo-Liang
GL
Wang
Yue-Min
YM
Ma
Heng
H
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D015854:Up-Regulation / Q000187:drug effects
D000975:Antioxidants; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D013267:Stilbenes; D009569:Nitric Oxide; D000077185:Resveratrol