title: Analysis of cardiovascular, acid-base status, electrolyte, and coagulation changes during small bowel transplantation.
abstract: The analysis of intraoperative hemodynamic, metabolic, and coagulation disorders of the recipients in relation to the newly reperfused organ during intestinal transplantation is necessary for an optimal patient management during small bowel transplantation (SBT). The interaction may be minor or may lead to postreperfusion syndrome, producing intense hemodynamic instability, important metabolic changes, and coagulation disorders. This research is based upon experience with 27 patients who underwent SBT. We observed significant decreases in PAM and IRVS after reperfusion in accordance with minor changes of mean pulmonary artery pressure, central venous pressure, and pulmonary capillary wedge pressure. The fall in pH upon revascularization was associated with a concomitant rise in partial carbon dioxide pressure probably due to the increased metabolic activity of the new organ. We found a significant increase in K levels, a rise that may be due to the output of metabolic products by the donor intestine. Patients displayed an hypocoagulative pattern, a derangement that did not seem to depend on ischemia time. It is possible that the same factors supporting the initial TEG pattern endure throughout the surgical procedure. The important and significant maximum amplitude indicator variation between the initial value and that after reperfusion may relate to the release of hypocoagulative factors superimposed on background abnormalities. These interesting metabolic disorders presumably reflected graft function and may provide predictive indices for a good outcome.
authors.affiliation: Department of Anaesthesia, Analgesia and Intensive Care, S. Orsola-Malpighi Hospital, Bologna, Italy. sinianest@libero.it
authors.forename: A
authors.initials: A
authors.lastname: Siniscalchi
authors.forename: E
authors.initials: E
authors.lastname: Piraccini
authors.forename: A
authors.initials: A
authors.lastname: Cucchetti
authors.forename: A
authors.initials: A
authors.lastname: Lauro
authors.forename: G
authors.initials: G
authors.lastname: Maritozzi
authors.forename: Z
authors.initials: Z
authors.lastname: Miklosova
authors.forename: M
authors.initials: M
authors.lastname: Ravaioli
authors.forename: A D
authors.initials: AD
authors.lastname: Pinna
authors.forename: S
authors.initials: S
authors.lastname: Faenza
mesh_terms: D000136:Acid-Base Equilibrium; D001777:Blood Coagulation; D002245:Carbon Dioxide / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D006439:Hemodynamics; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D004573:Electrolytes; D002245:Carbon Dioxide; D010100:Oxygen