Familial clustering in subgroups of gastric cancer stratified by histology, age group and location.
OBJECTIVE
To assess the risk of gastric cancer in a Japanese patient population with the disease by stratification with histology, age, tumour location and the association with family history of gastric or non-gastric tumours.


METHODS
A retrospective analysis of 1400 consecutive patients with gastric cancer and 13,467 age- and gender-matched controls from a pre-recorded database using conditional logistic regression models.


RESULTS
Young patients (< or = 43 years of age) with gastric cancer of intestinal type had a strong association with family history of gastric cancer in first degree-relatives (OR=12.5). Moreover, when a history of gastric cancer was observed in both parents, there was an increased risk of gastric cancer intestinal type (OR=7.8), more commonly in the proximal and mid-stomach. In contrast, there was an increased risk of diffuse-type cancer when both parents suffered non-gastric cancers (OR=2.1).


CONCLUSIONS
These data suggest that the degree of familial clustering differ in gastric cancer subgroups stratified by histology, age, and stomach location in this Japanese population.
Eto
K
K
Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan.
Ohyama
S
S
Yamaguchi
T
T
Wada
T
T
Suzuki
Y
Y
Mitsumori
N
N
Kashiwagi
H
H
Anazawa
S
S
Yanaga
K
K
Urashima
M
M
D017677:Age Distribution; D016000:Cluster Analysis; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology