title: Synthesis and evaluation of phenoxy acetic acid derivatives as [corrected] anti-mycobacterial agents.
abstract: In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1-3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H(37)Rv.
authors.affiliation: Faculty of Pharmacy, Jamia Hamdard University, Department of Pharmaceutical Chemistry, Hamdard Nagar, New Delhi, India. yarmsy@rediffmail.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shaharyar
authors.forename: Mohammad Shahar
authors.initials: MS
authors.lastname: yar
authors.forename: Anees Ahmad
authors.initials: AA
authors.lastname: Siddiqui
authors.forename: Mohamed Ashraf
authors.initials: MA
authors.lastname: Ali
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010642:Phenoxyacetates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010642:Phenoxyacetates