title: Prognostic value of MELD score and donor quality in liver transplantation: implications for the donor recipient match.
abstract: The model for End-stage Liver Disease (MELD) has been adopted by the Organ Procurement and Transplantation Network (OPTN) in 2002 as the standard priority rule for the liver transplantation waiting list. We retrospectively calculated the pretransplant MELD scores of 226 consecutive adult grafts. We did not correct for hepatocellular carcinoma comorbidity or for the etiology of liver disease. Cases were categorized according to the MELD score: class I, MELD scores between 6 and 14 (low MELD, n = 116); class II, MELD score between 15 and 24 (intermediate MELD, n = 78); class III, MELD score between 25 and 42 (high MELD, n = 32). All patients were transplanted using deceased donors. Grafts were categorized also according to donor quality (standard donor vs nonstandard donor). Sorting into categories was performed before transplant by officers of the Central-South Italian Transplant Organization overregional organ procurement agencies, namely OCST. Differences in Kaplan-Meier graft survivals (GS) between low MELD class and high MELD class were statistically significant (P < .01). Among standard donors, the 6-month GS were 83%, 94%, and 63% for the low, intermediate, and high MELD subset, respectively, differences that did not reach statistical significance. Among nonstandard donors, the 6-month GS were 77%, 71%, and 38% for the low, intermediate, and high MELD classes, respectively. Differences between low MELD class and intermediate MELD class and between low MELD class and high MELD class were statistically significant (P < .01). We strongly suggest that the utilization of nonstandard organs should be avoided for patients with high MELD scores.
authors.affiliation: Transplant Unit, A. Gemelli Hospital, Catholic University of Rome, Italy. alfonso.avolio@rm.unicatt.it
authors.forename: A W
authors.initials: AW
authors.lastname: Avolio
authors.forename: S
authors.initials: S
authors.lastname: Agnes
authors.forename: A
authors.initials: A
authors.lastname: Gasbarrini
authors.forename: E
authors.initials: E
authors.lastname: Nure
authors.forename: M
authors.initials: M
authors.lastname: Siciliano
authors.forename: M
authors.initials: M
authors.lastname: Castagneto
mesh_terms: D005500:Follow-Up Studies; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D017093:Liver Failure / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology / Q000592:standards / Q000706:statistics & numerical data*; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000458:organization & administration; D016896:Treatment Outcome