title: Early and late residual renal function and surgical complications in living donors: a 15-year experience at a single institution.
abstract: Living donation in the field of renal transplantation has increased over time as well as the use of laparoscopic nephrectomy. We present a 15-year experience on 162 living donors (105 women, 57 men; mean age, 46.7 years; range, 31-74 years) who underwent nephrectomy using different surgical approaches as open lombotomic nephrectomy (OLN), open transperitoneal nephrectomy (OTN), and laparoscopic hand-assisted nephrectomy (LHAN). We collected data on residual donor and recipient renal function, as well as early versus late medical and surgical complications. With a mean follow-up of about 8 years, we observed normal residual renal function in all donors and similar results of early and late graft function independent of the surgical procedure. Long-term incidence of hypertension and noninsulin-dependent diabetes in living donors was similar to the general population. OLN and OTN donors showed higher incidences of early and late complications, readmissions, and reoperations than LHAN donors. Our results confirmed that living donor nephrectomy is a safe procedure without serious side effects in terms of renal function and long-term quality of life. LHAN should be the preferred technique because of a lower incidence of early and late complications.
authors.affiliation: Kidney-Pancreas Transplantation Unit, Niguarda Hospital, Milan, Italy. chirtrapiantiadd@ospedaleniguarda.it
authors.forename: C V
authors.initials: CV
authors.lastname: Sansalone
authors.forename: G
authors.initials: G
authors.lastname: Maione
authors.forename: P
authors.initials: P
authors.lastname: Aseni
authors.forename: O
authors.initials: O
authors.lastname: Rossetti
authors.forename: I
authors.initials: I
authors.lastname: Mangoni
authors.forename: S
authors.initials: S
authors.lastname: Soldano
authors.forename: A
authors.initials: A
authors.lastname: De Roberto
authors.forename: M E
authors.initials: ME
authors.lastname: Minetti
authors.forename: M L
authors.initials: ML
authors.lastname: Perrino
authors.forename: G
authors.initials: G
authors.lastname: Civati
mesh_terms: D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D019520:Living Donors; D009392:Nephrectomy / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000145:classification; D012086:Reoperation; D012189:Retrospective Studies; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000009:adverse effects*; D016896:Treatment Outcome