Usefulness of LigaSure for liver resection: analysis by randomized clinical trial.
BACKGROUND
The goal of the present study was to evaluate the efficacy of the novel LigaSure Vessel Sealing System (Valleylab, Boulder, CO) when used for liver resection.


METHODS
Sixty patients (n = 30 in each group) with liver pathology from a single center were randomized to undergo liver resection with either the LigaSure system or with conventional clamping methods. Patients were stratified according to tumor size (<5 or >5 cm), type of hepatectomy (minor or major), and liver damage (normal or injured). Estimated blood loss during liver transection was used as the primary end point, whereas liver transection speed and morbidity rate were used as secondary end points.


RESULTS
There were no hospital deaths. The median blood loss during liver transection was less in the LigaSure than in the conventional group (200 vs 322 mL; P = .185). The amount of blood loss during minor hepatectomy was significantly less in the LigaSure than in the conventional group (186 vs 412 mL, P = .012). The liver transection speed was significantly faster in the LigaSure than in the conventional group (2.3 vs 1.6 cm(2)/min, P < .001. The number of ties required during liver transection was significantly less in the LigaSure than in the conventional group (6 vs 69 ties, P < .001). The morbidity rate was similar when comparing the 2 groups, indicating that the LigaSure sealing device and conventional methods had comparable efficacy in sealing the bile duct in the portal triad. Postoperative bile leak was observed in 1 patient (3%) in the LigaSure group and in 3 patients (9%) in the conventional group (P = .301).


CONCLUSIONS
The LigaSure system is an effective and safe tool for decreasing liver resection time.
Saiura
Akio
A
Department of Gastrointestinal Surgery, Cancer Institute, Ariake Hospital, 3-10-6 Ariake, Koto-ku, Tokyo 135-8500, Japan. saiura-tky@umin.ac.jp
Yamamoto
Junji
J
Koga
Rintaro
R
Sakamoto
Yoshihiro
Y
Kokudo
Norihiro
N
Seki
Makoto
M
Yamaguchi
Takuhiro
T
Yamaguchi
Toshiharu
T
Muto
Tetsuichiro
T
Makuuchi
Masatoshi
M
D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D006498:Hepatectomy / Q000295:instrumentation*; D006801:Humans; D008107:Liver Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome