title: Lamotrigine serum concentrations throughout the menstrual cycle--a study of 2 cases.
abstract: OBJECTIVE
  To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle.
  
  
  METHODS
  Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception.
  
  
  CONCLUSIONS
  The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically relevant changes in lamotrigine serum concentrations.
authors.affiliation: Department of Clinical Pharmacology, St Olavs University Hospital, Trondheim, Norway. arne.reimers@legemidler.no
authors.forename: Arne
authors.initials: A
authors.lastname: Reimers
authors.forename: Eylert
authors.initials: E
authors.lastname: Brodtkorb
authors.forename: Grethe
authors.initials: G
authors.lastname: Helde
authors.forename: Olav
authors.initials: O
authors.lastname: Spigset
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008597:Menstrual Cycle / Q000097:blood* / Q000187:drug effects; D014227:Triazines / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014227:Triazines; D000077213:Lamotrigine