title: Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates.
abstract: Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, Texas 78249-0698, USA.
authors.forename: Sampak
authors.initials: S
authors.lastname: Samanta
authors.forename: Cong-Gui
authors.initials: CG
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D006880:Hydroxy Acids / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D006880:Hydroxy Acids; D063065:Organophosphonates