[Constituents in the alkaloid fraction of Kushen decoction].
OBJECTIVE
To study the chemical constituents of the alkaloid fraction of Kushen decoction.


METHODS
Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods.


RESULTS
Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII).


CONCLUSIONS
All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.
Liu
Bin
B
School of Chinese Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. liubinyn67@163.com
Shi
Ren-Bing
RB
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D054837:Quinolizidines; D011807:Quinolizines / Q000737:chemistry / Q000302:isolation & purification; D032267:Rehmannia / Q000737:chemistry; D031364:Scutellaria baicalensis / Q000737:chemistry; D029909:Sophora / Q000737:chemistry; D000093842:Matrines
D000470:Alkaloids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010880:Piperidines; D054837:Quinolizidines; D011807:Quinolizines; C062701:aloperine; C035933:sophocarpine; C494416:kushen; D000093842:Matrines