Strumpell's disease in a family with hereditary focal segmental glomerulosclerosis.
Strumpell's familial spastic paraplegia is a rare hereditary disease, clinically characterized by progressive disturbance of gait. Focal Segmental Glomerulosclerosis (FSGS) is a frequent glomerulopathy, with an extremely rare familial subtype. The cases of two brothers with Strumpell' s disease are reported, who also developed glomerular renal disease, most probably familial FSGS. The genetics of the two disorders, Strumpell's paraplegia and familial FSGS, are discussed, together with the possibility of a parallel transmission.
Efstratiadis
Georgios
G
Department of Nephrology, Hippokration General Hospital, Thessaloniki, Greece. efstrati@med.auth.gr
Memmos
Dimitrios
D
Tsiaousis
Georgios
G
Pantzaki
Aphrodite
A
Manou
Helen
H
Logotheti
Vassiliki
V
D000328:Adult; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000235:genetics*; D007678:Kidney Glomerulus / Q000473:pathology*; D016030:Kidney Transplantation; D008297:Male; D006435:Renal Dialysis; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics*