Association between severity of inflammation in CNS and development of sunset glow fundus in Vogt-Koyanagi-Harada disease.
OBJECTIVE
To investigate the association between central nervous system (CNS) inflammation at disease onset and the appearance of sunset glow fundus (SGF) in Vogt-Koyanagi-Harada (VKH) disease.


METHODS
Retrospective case series.


METHODS
Charts of 102 patients with VKH disease followed from from initial onset were reviewed. The frequency of cerebrospinal fluid (CSF) pleocytosis and the number of cells in the CSF were compared among the patients who eventually developed SGF and the patients who had not developed SGF as of final follow-up.


RESULTS
SGF was observed in 69 (67.6%) of 102 patients. The frequency of CSF pleocytosis was 77 (82.7%) of 93 patients examined. The frequency of CSF pleocytosis and the number of cells in CSF were significantly higher in patients who eventually developed SGF (both P = .0029).


CONCLUSIONS
Severe inflammatory response in CNS sites at disease onset may influence the development of SGF in VKH disease.
Keino
Hiroshi
H
Department of Ophthalmology, Tokyo Medical University, Japan. hirojunharu@aol.com
Goto
Hiroshi
H
Mori
Hideki
H
Iwasaki
Takuya
T
Usui
Masahiko
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D015862:Choroid Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000134:cerebrospinal fluid; D008297:Male; D008580:Meningism / Q000150:complications; D008582:Meningitis, Aseptic / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D014012:Tinnitus / Q000150:complications; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000175:diagnosis