Successful pregnancy with spontaneous ovulation in a woman with apparent premature ovarian failure who failed to conceive despite four transfers of embryos derived from donated oocytes.
OBJECTIVE
To show that successful pregnancy is possible in a woman in apparent premature ovarian failure despite a serum follicle stimulating hormone (FSH) > 100 pg/ml.


METHODS
The high serum FSH was lowered with ethinyl estradiol. Progesterone (P) supplementation was to be used if ovulation was achieved.


RESULTS
Successful ovulation x2 was achieved by using .02 mg ethinyl estradiol. Progesterone vaginal suppositories (200 mg) twice daily were used in the luteal phase. Unfortunately pregnancy was not achieved. The couple elected to try donor oocytes after failing to ovulate on the third cycle. The patient spontaneously ovulated and conceived immediately after failing to become pregnant with four donor-oocyte transfers.


CONCLUSIONS
The suspicion was that the graduated dosage of estrogen used for the donor-oocyte cycles suppressed the FSH allowing her to respond to endogenous gonadotropins.
Check
J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Katsoff
B
B
D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000097:blood* / Q000150:complications
D004967:Estrogens; D004997:Ethinyl Estradiol; D004958:Estradiol; D005640:Follicle Stimulating Hormone