Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis.
BACKGROUND
The expression of bone morphogenetic proteins can be regarded as an indicator for biological interaction in distraction osteogenesis. It was hypothesized that different distraction rates may produce different patterns of BMP expression.


METHODS
This study compared the expression of BMP-2, -4 and -7 at routine (0.9mm once daily) and rapid (2.7mm once daily) distraction rates using the rabbit mandibular lengthening model. Mandibular samples were harvested at days 1, 7 and 14 of consolidation.


RESULTS
The expression of BMP-2 and BMP-4 was found throughout the experiment, their expression intensity and location being essentially similar, whereas BMP-7 had not been expressed. Expression of BMP-2 and -4 was more intense at the routine distraction rate than at the rapid distraction rate.


CONCLUSIONS
BMP-7 had no expression during the consolidation period of mandibular distraction. The change in the mechanical environment created by different distraction rates led to different expression of BMP-2 and -4. In the early consolidation stage the biological environment for bone formation created by distraction at a routine rate was superior to that created by the rapid distraction rate.
Cheung
Lim Kwong
LK
Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, the University of Hong Kong, Hong Kong, China. lkcheung@hkucc.hku.hk
Zheng
Li Wu
LW
Ma
Li
L
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000032:analysis / Q000378:metabolism*; D001861:Bone Regeneration / Q000502:physiology*; D006041:Goats; D008334:Mandible / Q000166:cytology / Q000378:metabolism* / Q000601:surgery; D023421:Models, Animal; D019857:Osteogenesis, Distraction / Q000379:methods*; D011817:Rabbits; D011994:Recombinant Proteins / Q000378:metabolism; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000032:analysis / Q000378:metabolism
D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2