title: Performance of an imaging system vs. manual screening in the detection of squamous intraepithelial lesions of the uterine cervix.
abstract: OBJECTIVE
  To compare the ThinPrep Imaging System (Cytyc Corp., Boxborough Massachusetts, U.S.A) to manual screening in the detection of cervical squamous epithelial lesion (SIL).
  
  
  METHODS
  A total of 27,525 manually screened ThinPrep Pap tests were compared with 27,725 imaged ThinPrep Pap tests for: (1) diagnostic rates of atypical squamous cells of undetermined significance; atypical squamous cells of undetermined significance, cannot rule out high grade SIL (ASC-H); low grade SIL and high grade SIL (HSIL); (2) ASC/SIL ratio; (3) high-risk HPV positivity for ASC; and (4) biopsy follow-up for ASC-H and HSIL.
  
  
  RESULTS
  There were significant increases in the percentage of cytologic diagnoses in all categories with the imager. The ASC/SIL ratios of both groups were comparable. There was a significant decrease in HPV positivity in the imager group of ASC. Biopsy results confirmed a significant increase in the detection of HSIL in both the ASC-H and HSIL groups of the imaged cohort.
  
  
  CONCLUSIONS
  The ThinPrep Imaging System is significantly better than manual screening in the detection of cervical SIL.
authors.affiliation: Depatment of Pathology and New England Pathology Associates, Mery Medical Center, Springfield, Massachusetts 01104, USA. kathleen.dziura@sphs.com
authors.forename: Bruce
authors.initials: B
authors.lastname: Dziura
authors.forename: Sarah
authors.initials: S
authors.lastname: Quinn
authors.forename: Kathleen
authors.initials: K
authors.lastname: Richard
mesh_terms: D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008403:Mass Screening; D015203:Reproducibility of Results; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods*