[Polymorphisms of aldehyde and alcohol dehydrogenase genes associated with susceptibility to trichloroethylene-induced medicamentosa-like dermatitis].
OBJECTIVE
Investigate the genetic polymorphisms of aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH), major enzymes involving the trichloroethylene (TCE) metabolism, associated with susceptibility to TCE-induced medicamentosa-like dermatitis.


METHODS
The study included 108 patients with TCE-induced medicamentosa-like dermatitis and 145 healthy controls exposed to TCE who were engaged in the same workplace, and frequency matched by sex and age. The genotypes of ADH2, ADH3 and ALDH2 were analyzed by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP), and distribution of genotype and odds ratio were calculated.


RESULTS
There were no differences in the frequencies of genotypes of ADH2 and ADH3 between cases and exposed controls. The frequency of heterozygous ALDH2 * 1/ * 2 plus homozygous ALDH2 * 2/ * 2 in cases was significantly lower than that in exposed controls (27.8% vs 43.4%, P = 0.011), and it decreased the risk of TCE-induced medicamentosa-like dermatitis (OR = 0.50, 95% CI = 0.29-0.85).


CONCLUSIONS
The active ALDH2 might be one of the factors influencing the individual susceptibility to TCE-induced medicamentosa-like dermatitis.
Li
Hai-shan
HS
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Dai
Yu-fei
YF
Huang
Han-lin
HL
Sun
Yao-feng
YF
D000293:Adolescent; D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D016022:Case-Control Studies; D009783:Dermatitis, Occupational / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014241:Trichloroethylene / Q000009:adverse effects*; D055815:Young Adult
D014241:Trichloroethylene; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase