title: Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio.
abstract: OBJECTIVE
  Ambient particulate air pollution has been associated with increased risk of cardiovascular morbidity and mortality. Pathways by which particles may act involve autonomic nervous system dysfunction or inflammation, which can affect cardiac rate and rhythm. The importance of these pathways may vary by particle component or source. In an eastern US location with significant regional pollution, the authors examined the association of air pollution and odds of cardiac arrhythmia in older adults.
  
  
  METHODS
  Thirty two non-smoking older adults were evaluated on a weekly basis for 24 weeks during the summer and autumn of 2000 with a standardised 30 minute protocol that included continuous electrocardiogram measurements. A central ambient monitoring station provided daily concentrations of fine particles (PM(2.5), sulfate, elemental carbon) and gases. Sulfate was used as a marker of regional pollution. The authors used logistic mixed effects regression to examine the odds of having any supraventricular ectopy (SVE) or ventricular ectopy (VE) in association with increases in air pollution for moving average pollutant concentrations up to 10 days before the health assessment.
  
  
  RESULTS
  Participant specific mean counts of arrhythmia over the protocol varied between 0.1-363 for SVE and 0-350 for VE. The authors observed odds ratios for having SVE over the length of the protocol of 1.42 (95% CI 0.99 to 2.04), 1.70 (95% CI 1.12 to 2.57), and 1.78 (95% CI 0.95 to 3.35) for 10.0 microg/m3, 4.2 microg/m3, and 14.9 ppb increases in five day moving average PM2.5, sulfate, and ozone concentrations respectively. The other pollutants, including elemental carbon, showed no effect on arrhythmia. Participants reporting cardiovascular conditions (for example, previous myocardial infarction or hypertension) were the most susceptible to pollution induced SVE. The authors found no association of pollution with VE.
  
  
  CONCLUSIONS
  Increased levels of ambient sulfate and ozone may increase the risk of supraventricular arrhythmia in the elderly.
authors.affiliation: Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. sebelt@sph.emory.edu
authors.forename: S E
authors.initials: SE
authors.lastname: Sarnat
authors.forename: H H
authors.initials: HH
authors.lastname: Suh
authors.forename: B A
authors.initials: BA
authors.lastname: Coull
authors.forename: J
authors.initials: J
authors.lastname: Schwartz
authors.forename: P H
authors.initials: PH
authors.lastname: Stone
authors.forename: D R
authors.initials: DR
authors.lastname: Gold
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000209:etiology; D002244:Carbon / Q000032:analysis / Q000633:toxicity; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis / Q000633:toxicity; D010126:Ozone / Q000032:analysis / Q000633:toxicity; D013458:Sulfur Dioxide / Q000032:analysis / Q000633:toxicity; D018754:Ventricular Dysfunction / Q000453:epidemiology* / Q000209:etiology
chemical_list: D000393:Air Pollutants; D013458:Sulfur Dioxide; D010126:Ozone; D002244:Carbon; D009585:Nitrogen Dioxide