Translational stroke research in the developing brain.
Preclinical animal models can help guide the development of clinical pediatric and newborn stroke trials. Data obtained using currently available models of hypoxia-ischemia and focal stroke have demonstrated the need for age-appropriate models. There are age-related differences in susceptibility of the immature brain to oxidative stress and inflammation, as well as in the rate and degree of apoptotic neuronal death. These issues need to be carefully addressed in designing future clinical trials.
Vexler
Zinaida S
ZS
Department of Neurology, University of California San Francisco, San Francisco, California 94143-0663, USA. zinaida@atsa.ucsf.edu
Sharp
Frank R
FR
Feuerstein
Giora Z
GZ
Ashwal
Stephen
S
Thoresen
Marianne
M
Yager
Jerome Y
JY
Ferriero
Donna M
DM
D000328:Adult; D000367:Age Factors; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D012107:Research Design; D020521:Stroke / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*