title: Constituents of stem bark of Callistemon rigidus showing inhibitory effects on mouse alpha-amylase activity.
abstract: From stem bark of Callistemon rigidus (Myrtaceae), piceatannol and scirpusin B were isolated as components that exhibit inhibitory effects on alpha-amylase activity in isolated mouse plasma. In particular, scirpusin B also inhibited alpha-amylase in mouse gastrointestinal tract. Thus, we expect the depressive effect on the elevation of postprandial blood glucose may be a new medicinal use of this compound as well as the plant itself.
authors.affiliation: Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Tamaki
authors.initials: T
authors.lastname: Ishihara
authors.forename: Eriko
authors.initials: E
authors.lastname: Khono
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000201:enzymology; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000097:blood
chemical_list: D001572:Benzofurans; D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013267:Stilbenes; C546905:scirpusin B; C041525:3,3',4,5'-tetrahydroxystilbene; D000516:alpha-Amylases