title: [Pharyngitis with necrotising pneumonia caused by Arcanobacterium haemolyticum].
abstract: A 20-year-old woman developed symptoms of pharyngitis followed by generalised skin rash and pulmonary infiltrates with cavitation. Arcanobacterium haemolyticum was identified in blood culture, which was susceptible to the antibiotics given. After initiating pathogen-directed therapy, the patient recovered completely. A. haemolyticum is a Gram-positive rod that can grow under aerobic and anaerobic conditions. The pathogen causes a characteristic haemolysis when cultured on human blood agar. A. haemolyticum causes pharyngitis and skin rash, particularly in adolescents. If the infection is not treated adequately, progression to more severe infections such as pneumonia, meningitis and sepsis can occur. The treatment of choice is a macrolide antibiotic.
authors.affiliation: Medisch Centrum Alkmaar, afd Longziekten, Alkmaar.
authors.forename: M M
authors.initials: MM
authors.lastname: van der Eerden
authors.forename: C S
authors.initials: CS
authors.lastname: de Graaff
authors.forename: W G
authors.initials: WG
authors.lastname: Boersma
authors.forename: F
authors.initials: F
authors.lastname: Vlaspolder
mesh_terms: D000191:Actinomycetaceae / Q000302:isolation & purification*; D000193:Actinomycetales Infections / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D010612:Pharyngitis / Q000175:diagnosis* / Q000188:drug therapy; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides