A non-myeloablative conditioning regimen in allogeneic stem cell transplantation from related and unrelated donors in elderly patients.
We describe our experience with the use of a single non-myeloablative preparative regimen in stem-cell transplantation (NST) in 37 heavily pretreated patients > or =55 years. The conditioning regimen consisted of fludarabine, low-dose busulfan, and antithymocyte globulin. Acute graft-versus-host disease (GVHD) grade III-IV and chronic GVHD developed in 15.6% and 44.4% of cases, respectively. With a median follow-up period of 22 (range 3-113) months, the 1-year overall survival and disease-free-survival were 55% and 53%, respectively, while the overall non-relapse mortality was 35%. In conclusion, reduced intensity stem cell transplantation is feasible and effective in patients > or =55 years. Age per se, should no longer be considered as a contra-indication to stem cell transplantation.
Tsirigotis
Panagiotis
P
Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah, Hebrew University Medical Center, Jerusalem, Israel.
Bitan
Reuven OrMenachem
RO
Resnick
Igor B
IB
Samuel
Simcha
S
Ackerstein
Aliza
A
Eladì
Sharon
S
Gesundheit
Benjamin
B
Zilberman
Irina
I
Miron
Svetlana
S
Leubovic
Alexander
A
Slavin
Shimon
S
Shapira
Michael Y
MY
D000368:Aged; D018572:Disease-Free Survival; D005190:Family; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D016019:Survival Analysis; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000401:mortality