Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
Kennedy
L J
LJ
Centre for Integrated Genomic Medical Research, University of Manchester, Oxford Road, Manchester M13 9PT, UK. lorna.kennedy@mahchester.ac.uk
Quarmby
S
S
Happ
G M
GM
Barnes
A
A
Ramsey
I K
IK
Dixon
R M
RM
Catchpole
B
B
Rusbridge
C
C
Graham
P A
PA
Hillbertz
N S
NS
Roethel
C
C
Dodds
W J
WJ
Carmichael
N G
NG
Ollier
W E R
WE
D000483:Alleles; D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000276:immunology*; D004285:Dogs; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D007037:Hypothyroidism / Q000235:genetics / Q000276:immunology / Q000662:veterinary*
D000949:Histocompatibility Antigens Class II