title: Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles.
abstract: Polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles were prepared by the thermal decomposition of Fe(CO)(5) (iron pentacarbonyl) in one step. X-ray diffraction (XRD), transmission electron microscopy (TEM), electrophoretic light scattering (ELS), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) together with the variation of the molar ratio of PVP/Fe(CO)(5), solvent, and molecular weight of PVP, were used to characterize the PVP-coated iron oxide nanoparticles. Fifty to hundred nanometer-sized iron oxide nanoclusters with a spherical shape were formed in dimethylformamide (DMF), used as a solvent, and exhibited an enhanced stability in the aqueous media. Their magnetic properties were investigated by superconducting quantum interface device (SQUID). The in vitro cytotoxicity test revealed that the PVP-coated iron oxide nanoparticles exhibited excellent biocompatibility by MTT assay. Magnetic resonance imaging (MRI) effect was observed with the administration of PVP-coated iron oxide nanoparticles through the marginal vein of rabbit, resulting in improved detection of the liver lesions.
authors.affiliation: Department of Advanced Organic Materials Engineering, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea.
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Nak Hyun
authors.initials: NH
authors.lastname: Lim
authors.forename: Jin A
authors.initials: JA
authors.lastname: Seo
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Kwak
authors.forename: Gilson
authors.initials: G
authors.lastname: Khang
authors.forename: Hai Bang
authors.initials: HB
authors.lastname: Lee
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho
mesh_terms: D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; D008279:Magnetic Resonance Imaging; D049329:Nanostructures; D011205:Povidone
chemical_list: D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; C000499:ferric oxide; D011205:Povidone