[Redox-potential of blood and consistence of energoproviding defence system in cytomegalovirus infection in pregnancy].
We have studied the relationship between the hypoxic change and mitochondrial redox-potential disturbances in the mechanism of pheto-placental insufficiency in pregnancy with cytomegalovirus infection (CMV), detected by the positive anti-CMV-IgG titer and more then 4-fold increase of low avid anti-CMV-IgG. It was shown, that chronic CMV infection induces production of active forms of oxygen, peroxidation of structures and concurrently damage of mitochondria with essential decrease of ATP level. Results of the study have shown the important diagnostic value of estimation of hypoxic-oxidative damage induced by CMV infection. The results also revealed important relationships between the activity of the CMV infection and intensity of mitochondrial damage. On the basis of our investigations we suggest the additional diagnostic test (the determination of citozol NADH dependent isocitratdehydrogenaze activity) to evaluate the depth of CMV induced metabolic disturbances.
Dzhikiia
I V
IV
Rizhvadze
M A
MA
Dzhangidze
M A
MA
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000150:complications / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood; D007521:Isocitrate Dehydrogenase / Q000032:analysis*; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000209:etiology; D010084:Oxidation-Reduction; D021041:Placental Circulation; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000378:metabolism
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D017382:Reactive Oxygen Species; D007521:Isocitrate Dehydrogenase