title: PolydA and polyrA self-structured by a europium and amino acid complex.
abstract: Different DNA selectivity was found for the newly synthesized europium-l-valine complex. Unexpected DNA and RNA selection results showed that europium-l-valine complex can cause single-stranded polydA and polyrA to self-structure. The sigmoidal melting curve profiles indicate the transition is cooperative, similar to the cooperative melting of a duplex DNA. This is different from another europium amino acid complex, europium-l-aspartic acid complex which can induce B-Z transition under the low salt condition. To our knowledge, there is no report to show that a metal-amino acid complex can cause the self-structuring of single-stranded DNA and RNA.
authors.affiliation: Key Laboratory of Rare Earth Chemistry and Physics, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Zhang
authors.forename: Haijia
authors.initials: H
authors.lastname: Yu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011061:Poly A / Q000737:chemistry*; D013057:Spectrum Analysis; D044366:Transition Temperature
chemical_list: D000596:Amino Acids; D011061:Poly A; C015465:poly(dA); D005063:Europium