title: Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
abstract: Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. nletvin@bidmc.harvard.edu
authors.forename: Norman L
authors.initials: NL
authors.lastname: Letvin
authors.forename: John R
authors.initials: JR
authors.lastname: Mascola
authors.forename: Yue
authors.initials: Y
authors.lastname: Sun
authors.forename: Darci A
authors.initials: DA
authors.lastname: Gorgone
authors.forename: Adam P
authors.initials: AP
authors.lastname: Buzby
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Yang
authors.forename: Bimal
authors.initials: B
authors.lastname: Chakrabarti
authors.forename: Srinivas S
authors.initials: SS
authors.lastname: Rao
authors.forename: Jörn E
authors.initials: JE
authors.lastname: Schmitz
authors.forename: David C
authors.initials: DC
authors.lastname: Montefiori
authors.forename: Brianne R
authors.initials: BR
authors.lastname: Barker
authors.forename: Fred L
authors.initials: FL
authors.lastname: Bookstein
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Nabel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D010957:Plasmids; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D016019:Survival Analysis; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D014779:Virus Replication
chemical_list: D018449:SAIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic