HLA-independent antibacterial host response toward Th1 immunity mediated by IL-12: a new concept for the pathogenesis of Adamantiades-Behçet's disease.
Yanagihori et al. found an HLA-independent higher frequency of IL-12B promoter polymorphism in Adamantiades-Behçet's disease (ABD) patients than in controls. Stimulation with streptococcal antigens specifically increased expression of patients' peripheral blood mononuclear cells IL-12 p40/p70. The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent.
Zouboulis
Christos C
CC
Department of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de
D000942:Antigens, Bacterial / Q000276:immunology; D001528:Behcet Syndrome / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology*; D014408:Biomarkers, Tumor / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics / Q000502:physiology*; D016858:Mycoplasma fermentans / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000502:physiology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D013290:Streptococcal Infections / Q000276:immunology; D013298:Streptococcus sanguis / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology* / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology
D000942:Antigens, Bacterial; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D006680:HLA Antigens; D025521:Tumor Suppressor Proteins; D018664:Interleukin-12; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase