T cell-dendritic cell immunological synapses.
Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns.
Dustin
Michael L
ML
Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA.
Tseng
Su-Yi
SY
Varma
Rajat
R
Campi
Gabriele
G
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008051:Lipid Bilayers / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D008051:Lipid Bilayers