Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles.
Polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles were prepared by the thermal decomposition of Fe(CO)(5) (iron pentacarbonyl) in one step. X-ray diffraction (XRD), transmission electron microscopy (TEM), electrophoretic light scattering (ELS), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) together with the variation of the molar ratio of PVP/Fe(CO)(5), solvent, and molecular weight of PVP, were used to characterize the PVP-coated iron oxide nanoparticles. Fifty to hundred nanometer-sized iron oxide nanoclusters with a spherical shape were formed in dimethylformamide (DMF), used as a solvent, and exhibited an enhanced stability in the aqueous media. Their magnetic properties were investigated by superconducting quantum interface device (SQUID). The in vitro cytotoxicity test revealed that the PVP-coated iron oxide nanoparticles exhibited excellent biocompatibility by MTT assay. Magnetic resonance imaging (MRI) effect was observed with the administration of PVP-coated iron oxide nanoparticles through the marginal vein of rabbit, resulting in improved detection of the liver lesions.
Lee
Ha Young
HY
Department of Advanced Organic Materials Engineering, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea.
Lim
Nak Hyun
NH
Seo
Jin A
JA
Yuk
Soon Hong
SH
Kwak
Byung Kook
BK
Khang
Gilson
G
Lee
Hai Bang
HB
Cho
Sun Hang
SH
D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; D008279:Magnetic Resonance Imaging; D049329:Nanostructures; D011205:Povidone
D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; C000499:ferric oxide; D011205:Povidone