title: Patterns of salivary gland uptake in I-131 MIBG scintigraphy.
abstract: I-131 MIBG scintigraphy is routinely used in the diagnosis of neuroendocrine tumours with high specificity. The radiopharmaceutical is taken up via uptake mechanism and actively transported into storage vesicules. The organs with dense sympathetic innervation such as salivary glands, heart, lachrymal glands, spleen and rarely adrenal medulla are normally visualized with I-131 MIBG. Asymetrical salivary gland uptake is important in a patient with suspected neuroendocrine tumours. Absence of radioactivity may be a result of sympathic denervation or tumor. Bilateral radioactivity absence is observed usually due to drugs or radiopharmaceutical storage conditions. Detailed examination of cervical region is crucial for localisation of neuroendocrine tumours. Therefore, possible false positives should be kept in mind.
authors.affiliation: Nuclear Medicine Department, Hacettepe University Faculty of Medicine, Ankara, Turkey. bilgev@hacettepe.edu.tr
authors.forename: B Volkan
authors.initials: BV
authors.lastname: Salanci
authors.forename: E Lay
authors.initials: EL
authors.lastname: Ergün
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging*; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D004356:Drug Storage; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis; D006732:Horner Syndrome / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007454:Iodides / Q000008:administration & dosage; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging*; D010235:Paraganglioma / Q000175:diagnosis; D010306:Parotid Gland / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000209:etiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis; D012469:Salivary Glands / Q000000981:diagnostic imaging*; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics; D013363:Submandibular Gland / Q000000981:diagnostic imaging; D013562:Sympathectomy; D013696:Temperature; D014018:Tissue Distribution; D016312:Treatment Refusal
chemical_list: D007454:Iodides; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D013670:Sodium Pertechnetate Tc 99m; C010389:Lugol's solution