title: Silent ischemia after neuroprotected percutaneous carotid stenting: a diffusion-weighted MRI study.
abstract: OBJECTIVE
  To assess by diffusion-weighted MR imaging (DWI) the efficacy of cerebral protection devices in avoiding embolization and new ischemic lesions in patients with severe internal carotid artery (ICA) stenosis undergoing carotid artery stent placement (CAS).
  
  
  METHODS
  One hundred sixty-two CASs in the extracranial ICA were performed with the use of distal filters. Mean age of the patients was 68.5 years (range, 33-86) and 122 patients (75.3%) were symptomatic. MR imaging was performed in all patients during the 3-day period before CAS, and DWI was obtained within 24 hours after the procedure. Ninety-five patients (58.6%) were monitored by transcranial Doppler ultrasonography for microemboli detection in the territory of the middle cerebral artery (MCA), ipsilateral to the vessel being treated.
  
  
  RESULTS
  Twenty-eight patients (17.3%) showed 58 new ischemic foci in DWI, and 13 patients (46.4%) had multiple foci. Location of new lesions was mainly in the vascular territory supplied by the treated vessel (19 patients; 67.9%), but also in the contralateral MCA (1 patient; 3.6%), and the posterior fossa (4 patients; 14.3%). A significant relationship (P < .03) was found between occurrence of transient ischemic attack (TIA) and appearance of new lesions. Microembolic signals (MES) were detected in 88 patients (92.6%), with no relationship between number of MES and the appearance of new ischemic foci.
  
  
  CONCLUSIONS
  New ischemic foci were observed in 17.3% of the patients undergoing neuroprotected CAS. Appearance of new ischemic lesions were only significantly related to the occurrence of TIA but not to the number of MES registered or other variables. Despite the encouraging results, the incidence of new ischemic lesions should promote research for safer techniques and devices.
authors.affiliation: Section of Neuroradiology, Hospitales Universitarios Virgen del Rocío, 41013 Seville, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Piñero
authors.forename: A
authors.initials: A
authors.lastname: González
authors.forename: A
authors.initials: A
authors.lastname: Mayol
authors.forename: E
authors.initials: E
authors.lastname: Martínez
authors.forename: J R
authors.initials: JR
authors.lastname: González-Marcos
authors.forename: F
authors.initials: F
authors.lastname: Boza
authors.forename: A
authors.initials: A
authors.lastname: Cayuela
authors.forename: A
authors.initials: A
authors.lastname: Gil-Peralta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000800:Angioplasty, Balloon / Q000009:adverse effects*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000175:diagnosis* / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional; D015607:Stents / Q000009:adverse effects*