title: No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits.
abstract: Clara cell secretory protein (CC16) is an anti-inflammatory protein expressed in the respiratory tract. Several studies have suggested the association between CC16 and mental disturbances, such as schizophrenia, depression, and post-traumatic stress disorder. In the present study, we investigated the association between the CC16 gene A38G polymorphism and personality traits in 214 healthy Japanese subjects. Personality traits were evaluated by using the Revised NEO Personality Inventory (NEO PI-R) and the State-Trait Anxiety Inventory (STAI). As a result, no significant association was observed between the genotypes and the scores of the NEO PI-R or the STAI. The present results suggest that CC16 may not have a major role in the development of personality traits.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hibino
authors.forename: Chieko
authors.initials: C
authors.lastname: Kato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Marui
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ohtani
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D010551:Personality / Q000235:genetics*; D010556:Personality Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D014598:Uteroglobin / Q000235:genetics*
chemical_list: C556389:SCGB1A1 protein, human; D014598:Uteroglobin