title: Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.
abstract: Several recent studies have demonstrated the possible involvement of the microsomal glutathione S-transferase 2 (MGST2) gene in the pathogenesis of psoriasis. The objectives of this work are to determine whether the genetic polymorphisms of the MGST2 gene were associated with an increased risk of psoriasis in Chinese patients. We first characterized the linkage disequilibrium pattern within MGST2 and identified single-nucleotide polymorphisms (SNPs) for tagging common genetic variants. Genotype- and haplotype-based analyses were then performed by genotyping the Tag SNPs in a large-scale sample of cases and controls. We characterized the linkage disequilibrium pattern within MGST2 using 12 densely distributed SNPs and identified 6 SNPs for tagging common genetic variants. We then performed an association analysis by genotyping the six SNPs in 552 cases and 384 controls, but none of the genotype- and haplotype-based analyses revealed significant evidence for association. We also performed family-based association analysis by genotyping the six SNPs in 95 trios; no evidence for association was identified. Our comprehensive genetic analysis of MGST2 common variants in a large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the susceptibility gene within the PSORS9 locus.
authors.affiliation: Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Kai-Lin
authors.initials: KL
authors.lastname: Yan
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Xiao
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Peng-Guang
authors.initials: PG
authors.lastname: Wang
authors.forename: Guo-Long
authors.initials: GL
authors.lastname: Zhang
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Wang
authors.forename: Kai-Yue
authors.initials: KY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D008875:Middle Aged; D011565:Psoriasis / Q000201:enzymology* / Q000235:genetics
chemical_list: D005982:Glutathione Transferase