Optical properties of wounds: diabetic versus healthy tissue.
Diffuse photon density wave (DPDW) methodology at Near Infrared frequencies has been used to calculate absorption and scattering from wounds of healthy and diabetic rats. The diffusion equation for semi-infinite media is being used for calculating the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. Differences observed during the course of healing in the two populations can be correlated to the delayed healing observed in diabetics. These results are encouraging and further work will focus on the implementation of this device to the clinical setting as a monitoring tool in chronic diabetic wounds.
Papazoglou
Elisabeth S
ES
School of Biomedical Engineering and Science, Drexel University, Philadelphia, PA 19104, USA. elisabeth.s.papazoglou@drexel.edu
Weingarten
Michael S
MS
Zubkov
Leonid
L
Zhu
Linda
L
Tyagi
Som
S
Pourrezaei
Kambiz
K
D000818:Animals; D048909:Diabetes Complications / Q000175:diagnosis* / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005260:Female; D008027:Light; D051381:Rats; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods*; D014945:Wound Healing / Q000502:physiology; D014950:Wounds, Penetrating / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*