Indocyanine green angiographic features of myopic subfoveal choroidal neovascularization as a prognostic factor after photodynamic therapy.
OBJECTIVE
To determine the influence of clinical features and Indocyanine green (ICG) angiographic features on the visual outcome of patients with myopic sub-foveal choroidal neovascularization (CNV) who received photodynamic therapy (PDT).


METHODS
Thirty-six consecutive patients (39 eyes) with myopic CNV who were followed up for more than one year after PDT were enrolled in this study. Clinical features included age, gender, refractive error, great linear dimension, and subretinal hemorrhage. ICG features included the lesion size, lacquer cracks, hypofluorescence surrounding the CNV (dark rim), peripapillary atrophy size, and visible prominent choroidal veins under the macula. Linear regression analysis was performed using the change in visual acuity (delta logMAR) as the dependent variable and the above factors as independent variables.


RESULTS
At one-year follow-up after PDT, a younger age (p = 0.002) and the presence of a dark rim (p = 0.002) were significantly correlated with an improvement of visual acuity (decrement in logMAR) after PDT. Other factors had no significant influence on changes in visual acuity.


CONCLUSIONS
Younger patients and patients with a dark rim on ICG angiography had a higher chance of visual improvement after PDT in myopic CNV.
Byeon
Suk Ho
SH
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Kwon
Oh Woong
OW
Lee
Sung Chul
SC
Kim
Sung Soo
SS
Koh
Hyoung Jun
HJ
D000328:Adult; D000368:Aged; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000473:pathology; D010778:Photochemotherapy; D011379:Prognosis; D012189:Retrospective Studies; D014792:Visual Acuity
D004396:Coloring Agents; D007208:Indocyanine Green