In vitro leishmanicidal constituents of Millettia pendula.
The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.
Takahashi
Marii
M
Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Tsukuba, Ibaraki 305-0843, Japan.
Fuchino
Hiroyuki
H
Sekita
Setsuko
S
Satake
Motoyoshi
M
Kiuchi
Fumiyuki
F
D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology; D016227:Benzoquinones / Q000494:pharmacology; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D033641:Millettia / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry
D000977:Antiparasitic Agents; D016227:Benzoquinones; D007529:Isoflavones; D010936:Plant Extracts; C543885:millettilone A; C543886:millettilone B; C007768:formononetin; C088068:claussequinone