title: In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.
abstract: The standardization and reproducibility of techniques required to acquire anatomically localized 31P MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 T are reported. This initial group of patients was studied from 1995 to 2000 to test the feasibility of acquiring in vivo localized 31P MRS in clinical MR spectrometers. The cancers tested were non-Hodgkin's lymphomas, sarcomas of soft tissue and bone, breast carcinomas and head and neck carcinomas. The best accrual and spectral quality were achieved with the non-Hodgkin's lymphomas. The initial analysis of the spectral values of the sum of phosphoethanolamine plus phosphocholine normalized by the content of nucleotide triphosphates in a homogeneous sample of 32 NHL patients studied by in vivo (31)P MRS showed good reproducibility among different institutions. No statistical differences were found between the institution with the largest number of cases accrued and the rest of the multi-institutional NHL data (2.28 +/- 0.64, mean +/- standard error; n = 17, vs 2.08 +/- 0.14, n = 15). The preliminary data reported demonstrate that the institutions involved in this trial are obtaining reproducible 31P MR spectroscopic data non-invasively from human tumors. This is a fundamental prerequisite for the international cooperative group to be able to demonstrate the clinical value of the normalized determination of phosphoethanolamine plus phosphocholine by 31P MRS as predictor for treatment response in cancer patients.
authors.affiliation: Hatch Center for MR Research, Radiology Department, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. fa2003@columbia.edu
authors.forename: F
authors.initials: F
authors.lastname: Arias-Mendoza
authors.forename: G S
authors.initials: GS
authors.lastname: Payne
authors.forename: K L
authors.initials: KL
authors.lastname: Zakian
authors.forename: A J
authors.initials: AJ
authors.lastname: Schwarz
authors.forename: M
authors.initials: M
authors.lastname: Stubbs
authors.forename: R
authors.initials: R
authors.lastname: Stoyanova
authors.forename: D
authors.initials: D
authors.lastname: Ballon
authors.forename: F A
authors.initials: FA
authors.lastname: Howe
authors.forename: J A
authors.initials: JA
authors.lastname: Koutcher
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: J R
authors.initials: JR
authors.lastname: Griffiths
authors.forename: A
authors.initials: A
authors.lastname: Heerschap
authors.forename: J D
authors.initials: JD
authors.lastname: Glickson
authors.forename: S J
authors.initials: SJ
authors.lastname: Nelson
authors.forename: J L
authors.initials: JL
authors.lastname: Evelhoch
authors.forename: H C
authors.initials: HC
authors.lastname: Charles
authors.forename: T R
authors.initials: TR
authors.lastname: Brown
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D010758:Phosphorus; D017553:Phosphorus Compounds / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014481:United States
chemical_list: D014408:Biomarkers, Tumor; D017553:Phosphorus Compounds; D010758:Phosphorus