Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus.
BACKGROUND
Efforts are made in a continued searching for novel therapies for symptomatic oral lichen planus (OLP). This study aimed to evaluate the efficacy and safety of intralesional triamcinolone acetonide (TA) injection for ulcerative OLP.


METHODS
Forty-five patients with clinical and histologically confirmed ulcerative OLP on bilateral buccal mucosa, one for treatment and the other for control, were studied. All participants received 0.5 ml TA (40 mg/ml) on experimental sites. Visual analogue scale score and lesion areas were recorded at the time of injection and 1-week interval. After 2 weeks, if the treated ulceration reduced < 81% in size, a second injection was given.


RESULTS
The treated group gave rapid relief of signs and symptoms, while the control group showed minimal decrease. 38 (84.4%) patients demonstrated complete response in ulceration size. No complications were noted with TA injections.


CONCLUSIONS
Intralesional TA injection in ulcerative OLP is effective and safe in achieving lesion and pain regression.
Xia
Juan
J
Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen University, No. 56 Lingyuanxi Road, Guangzhou, Guangdong 510 055, China.
Li
Chunyang
C
Hong
Yun
Y
Yang
Linglan
L
Huang
Yulei
Y
Cheng
Bin
B
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D017676:Lichen Planus, Oral / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000188:drug therapy / Q000473:pathology; D012720:Severity of Illness Index; D016037:Single-Blind Method; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide