[Advances in studies on potential toxicity of flavonoids].
Flavonoids, including flavones, flavonols, anthocyanins, flavanones, chalcones, flavan, proanthocyanidins, isoflavonoids and biflavonoids, etc, are natural components in our diet and plants. Several beneficial properties have been attributed to these compounds, including antioxidant, anti-inflammatory and anticarcinogenic effects, etc. Flavonoid preparations are marketed as herbal medicines or dietary supplements for a variety of alleged nontoxic therapeutic effects. However, they have yet to pass controlled clinical trials for efficacy, and their potential for toxicity is an understudied field of research. This review summarizes the current studies on the toxicity induced by flavonoids and gives some advices for ingesting flavonoids.
Lu
Bai-Yi
BY
College of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310029, China. bylu@zju.edu.cn
Zhang
Ying
Y
Wu
Xiao-Qin
XQ
D000818:Animals; D000975:Antioxidants / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D019587:Dietary Supplements / Q000009:adverse effects / Q000633:toxicity*; D004347:Drug Interactions; D005419:Flavonoids / Q000009:adverse effects / Q000302:isolation & purification / Q000633:toxicity*; D016166:Free Radical Scavengers / Q000633:toxicity; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids; D016166:Free Radical Scavengers; D007529:Isoflavones; D003577:Cytochrome P-450 Enzyme System