Mechanisms of hepatoprotective effect of preparation containing superlow doses of antibodies to granulocytic colony-stimulating factor.
The hepatoprotective effects of superlow dose preparation of antibodies to granulocytic CSF were studied on a model of CCl4-induced hepatitis. The preparation exhibited high antiinflammatory and antisclerotic activities determined by stimulation, mobilization, and determined homing of mesenchymal stem cells into damaged liver with subsequent differentiation of these cells into mature hepatocytes.
Epstein
O I
OI
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Zyuz'kov
G N
GN
Sotnikova
N V
NV
Stavrova
L A
LA
Fomina
T I
TI
Vetoshkina
T V
TV
Sergeeva
S A
SA
Dubskaya
T Yu
TY
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D002454:Cell Differentiation; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology* / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism
D000906:Antibodies; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor