title: Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa.
abstract: By means of a videomicroscopy system and a computer image analysis, we performed chemotaxis assays to detect true chemotaxis in human spermatozoa, in parallel to immunohistochemistry detection of progesterone inside the cumulus cells. Progesterone indeed chemotactically guides mammalian spermatozoa at very low hormone concentrations, and the cumulus oophorus could be a potential place for sperm chemotaxis mediated by progesterone in vivo.
authors.affiliation: Center for Cellular and Molecular Biology, Faculty of Sciences, National University of Córdoba, Córdoba, Argentina.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Teves
authors.forename: Flavia
authors.initials: F
authors.lastname: Barbano
authors.forename: Héctor Alejandro
authors.initials: HA
authors.lastname: Guidobaldi
authors.forename: Raúl
authors.initials: R
authors.lastname: Sanchez
authors.forename: Werner
authors.initials: W
authors.lastname: Miska
authors.forename: Laura Cecilia
authors.initials: LC
authors.lastname: Giojalas
mesh_terms: D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000008:administration & dosage; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011374:Progesterone / Q000008:administration & dosage*; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*
chemical_list: D002630:Chemotactic Factors; D011374:Progesterone