title: Apoptosis in hypertensive heart disease: a clinical approach.
abstract: OBJECTIVE
  It is widely accepted that there are two principal forms of cell death, namely, necrosis and apoptosis. According to the classical view, necrosis is the major mechanism of cardiomyocyte death in cardiac diseases.
  
  
  BACKGROUND
  In the past few years observations have been made showing that cardiomyocyte apoptosis occurs in diverse conditions including hypertensive heart disease, and that apoptosis may be a contributing cause of loss and functional abnormalities of cardiomyocytes in this condition.
  
  
  CONCLUSIONS
  This review will summarize recent evidence demonstrating the potential contribution of cardiomyocyte apoptosis to heart failure in hypertensive patients. In addition, some strategies aimed to detect and prevent apoptosis of cardiomyocytes will be considered.
authors.affiliation: Division of Cardiovascular Sciences, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: González
authors.forename: Susana
authors.initials: S
authors.lastname: Ravassa
authors.forename: Begoña
authors.initials: B
authors.lastname: López
authors.forename: Iñigo
authors.initials: I
authors.lastname: Loperena
authors.forename: Ramón
authors.initials: R
authors.lastname: Querejeta
authors.forename: Javier
authors.initials: J
authors.lastname: Díez
mesh_terms: D017209:Apoptosis; D002470:Cell Survival; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D032383:Myocytes, Cardiac; D009336:Necrosis