title: Neuropathologic findings in essential tremor.
abstract: Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.
authors.affiliation: GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. EDL2@columbia.edu
authors.forename: E D
authors.initials: ED
authors.lastname: Louis
authors.forename: J P G
authors.initials: JP
authors.lastname: Vonsattel
authors.forename: L S
authors.initials: LS
authors.lastname: Honig
authors.forename: G W
authors.initials: GW
authors.lastname: Ross
authors.forename: K E
authors.initials: KE
authors.lastname: Lyons
authors.forename: R
authors.initials: R
authors.lastname: Pahwa
mesh_terms: D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D020329:Essential Tremor / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male