title: An uncommon case of diabetic mastopathy in type II non-insulin dependent diabetes mellitus.
abstract: Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in a patient who has suffered from type I diabetes mellitus of long duration. Here we report a rare case of diabetic mastopathy that occurred in type II non-insulin dependent diabetes mellitus. This patient was a 63-year-old postmenopausal woman. Mammography, ultrasonography and MR imaging could not distinguish it from breast cancer. Although the core needle biopsy specimen showed fibrosis without evidence of malignancy, excisional biopsy was performed. Histological findings demonstrated typical diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy.
authors.affiliation: Department of Surgery, Fussa Hospital, Fussa City, Tokyo, Japan. soutome@fussahp.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sotome
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Ryo
authors.initials: R
authors.lastname: Miyoshi
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamaru
authors.forename: Akio
authors.initials: A
authors.lastname: Furukawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Kyoei
authors.initials: K
authors.lastname: Morozumi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hisami
authors.initials: H
authors.lastname: Iri
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods; D015412:Mastectomy, Segmental; D008875:Middle Aged; D017698:Postmenopause; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D016217:Ultrasonography, Mammary / Q000379:methods