title: Spectrum of neurological involvement in adult patients with bacterial endocarditis.
abstract: OBJECTIVE
  To describe the spectrum of neurological involvement, and document in-hospital mortality in adult patients with bacterial endocarditis.
  
  
  METHODS
  Descriptive, non-interventional.
  
  
  METHODS
  Department of Gastroenterology, The Aga Khan University Hospital, Karachi from November 1999 to October 2002.
  
  
  METHODS
  Patients were enrolled from the emergency and outpatient departments, using purposive, non-probability sampling, provided they fulfilled pre-defined inclusion and exclusion criteria. Case records of patients admitted to hospital with a diagnosis of bacterial endocarditis were prospectively analyzed. Data was entered and analyzed on SPSS 11. Frequency, Mean, Mode and Percentage were calculated.
  
  
  RESULTS
  Neurological complications were observed in 14 out of 40 patients (35%). The most frequent complication was embolic infarction (33%), followed by intra-cranial hemorrhage (22 %). Seizures, encephalopathy, abscess and meningitis were all observed in decreasing order of frequency. Out of a total of 14 patients who suffered neurological complications, 06 died (42 %).
  
  
  CONCLUSIONS
  The nervous system is frequently involved in patients with bacterial endocarditis. The nature of neurological involvement can vary from a fatal embolic infarction to infective complications, such as cerebral abscess or meningitis, to mild encephalopathy. The most frequently noted complication was embolic infarction. In-hospital mortality is significantly high in patients who suffer neurological complications.
authors.affiliation: Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan. faisal.ismail@aku.edu
authors.forename: Faisal Wasim
authors.initials: FW
authors.lastname: Ismail
authors.forename: Muhammad
authors.initials: M
authors.lastname: Tariq
authors.forename: Mehboob
authors.initials: M
authors.lastname: Alam
authors.forename: Muhammad Ata
authors.initials: MA
authors.lastname: Khan
authors.forename: Raymond
authors.initials: R
authors.lastname: Smego
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000209:etiology*; D004697:Endocarditis, Bacterial / Q000150:complications*; D006801:Humans; D011446:Prospective Studies