title: Intra-arterial hepatic chemotherapy: management of liver tumors by percutaneous port-a-cath positioning.
abstract: In the past, intrahepatic arterial locoregional chemotherapy was performed by surgical approach via gastroduodenal artery; early use of percutaneously placed arterial port was complicated by clotting and bleeding in 50% of pts. More recently, permanent catheters were positioned percutaneously in GDA by Japanese group and fixed to the artery by means of bucrylate in order to reduce dislocation. We present the technique and the preliminary results of percutaneous implantation of intraarterial catheters connected to a subcutaneous infusion reservoir for prolonged regional chemotherapy of hepatic tumors. Two hundred patients underwent to percutaneous arterial port implant, for loco-regional chemotherapy for liver primary or metastatic tumors. Catheter dislodgments were observed in 14,5%, but in 90% the catheters could be reinserted. No case of catheter related mortality was registered. Percutaneous positioning of arterial port is a safe and effective technique to deliver loco-regional treatment for hepatic tumors. Complication rates are similar to the surgical series and to other percutaneous interventional radiological reports. This percutaneous approach in the hands of a skilled team allows intra-arterial infusion in a wide percentage of pts, improving the accuracy of clinical trials by a faster and optimal balanced comparison between systemic and arterial arm.
authors.affiliation: Department of Radiology, Santa Croce Hospital, Cuneo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Grosso
authors.forename: A
authors.initials: A
authors.lastname: Scarrone
authors.forename: F
authors.initials: F
authors.lastname: Pedrazzini
authors.forename: R
authors.initials: R
authors.lastname: Priotto
authors.forename: F
authors.initials: F
authors.lastname: Testa
authors.forename: G
authors.initials: G
authors.lastname: Lingua
authors.forename: I
authors.initials: I
authors.lastname: Mondino
authors.forename: C
authors.initials: C
authors.lastname: Zanon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002408:Catheters, Indwelling / Q000009:adverse effects*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006499:Hepatic Artery / Q000601:surgery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents