[Expression and clinical significance of Beclin1 and PTEN in endometrial carcinoma].
OBJECTIVE
The pathogenesis of endometrial carcinoma is unclear. This study was to explore the expression of beclin1 (BECN1) and PTEN in endometrial carcinoma, and investigate their correlations to clinicopathologic features of endometrial carcinoma.


METHODS
The expression of BECN1 and PTEN in 79 specimens of endometrial carcinoma, 34 specimens of endometrial hyperplasia, and 22 specimens of normal endometria were detected by PowerVision immunohistochemistry. Their correlations to clinicopathologic features of endometrial carcinoma were analyzed.


RESULTS
The positive rates of BECN1 and PTEN were the highest in normal endometria, and diminished gradually in endometrial hyperplasia and endometrial carcinoma (93.33%, 58.82%, and 34.18%, Chi (2)=42.318, P<0.001, 93.33%, 64.71%, and 32.91%, Chi(2)=31.746, P<0.001). The expression of BECN1 was correlated to cell differentiation and histological type, but not to pathologic stage and myometrial invasion. The expression of PTEN was correlated to cell differentiation, histological type, and myometrial invasion, but not to pathologic stage. The expression of BECN1 was positively correlated to that of PTEN in endometrial carcinoma.


CONCLUSIONS
The down-regulation of BECN1 and PTEN may be correlated to carcinogenesis of endometrioid adenocarcinoma.
Zhao
Jian-Hong
JH
Hospital of Obstetrics and Gynecology, Zhejiang University, Hangzhou, Zhejiang, 310006, P. R. China.
Wan
Xiao-Yun
XY
Xie
Xing
X
Zhou
Cai-Yun
CY
Wu
Qiong-Yan
QY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D000071186:Beclin-1; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D015536:Down-Regulation; D004714:Endometrial Hyperplasia / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D051059:PTEN Phosphohydrolase / Q000378:metabolism*
D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human