title: Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus.
abstract: Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) played a role in the eating behavior and glucose and lipid metabolism. In this study we measured the serum BDNF levels in newly diagnosed female patients with type 2 diabetes mellitus (n = 24, aged 34-59 years) and female subjects with normal glucose tolerance (n = 7, aged 34-56 years). The serum BDNF level was found to significantly increase in diabetic patients in comparison to that in healthy subjects (P < .05). In these patients, the serum BDNF level showed positive correlation with the body mass index (r = 0.535, P < .01), the percentage of body fat (r = 0.552, P < .01), the subcutaneous fat area based on computed tomography scan (r = 0.480, P < .05), the triglyceride level (r = 0.470, P < .05), the fasting blood glucose level (r = 0.437, P < .05), and the homeostasis model assessment of insulin resistance score (r = 0.506, P < .05), whereas it showed a negative correlation with age (r = -0.486, P < .05). The partial correlation coefficients adjusted by age showed significant differences regarding the body mass index (r = 0.423, P < .05), percentage of body fat (r = 0.504, P < .05), and triglyceride level (r = 0.426, P < .05). These results provide the first evidence that an increased BDNF is associated with a prevalence of type 2 diabetes mellitus. In addition, the BDNF is related to the total and abdominal subcutaneous fat mass and energy metabolism in the newly diagnosed female patients with type 2 diabetes mellitus.
authors.affiliation: Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816-8580, Japan. suwa-m@students.ihs.kyushu-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Suwa
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Kishimoto
authors.forename: Yu
authors.initials: Y
authors.lastname: Nofuji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Haruka
authors.initials: H
authors.lastname: Sasaki
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Radak
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kumagai
mesh_terms: D000328:Adult; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger