Evolving patterns of lymphopoiesis from embryogenesis through senescence.
Lymphopoiesis occurs throughout adult life, but the number of lymphocytes produced is substantially reduced in old individuals. This commentary will highlight observations suggesting that common mechanisms underlie declines in both B and T cell production and that reductions in lymphopoiesis are initiated much earlier than has generally been appreciated.
Montecino-Rodriguez
Encarnacion
E
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095.
Dorshkind
Kenneth
K
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095. Electronic address: kdorshki@mednet.ucla.edu.
D000375:Aging / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D047108:Embryonic Development / Q000276:immunology; D038041:Lymphopoiesis; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology