Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a five-year longitudinal study.
Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. alpha-tocopherol, beta-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), beta-carotene and alpha-tocopherol were positively associated with survival. alpha-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high alpha-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses.
Huerta
José M
JM
Departamento de Biología Funcional, Area de Fisiología. Facultad de Medicina, Universidad de Oviedo, Julián Clavería s/n, Oviedo 33006, Spain.
González
Sonia
S
Fernández
Serafina
S
Patterson
Angeles M
AM
Lasheras
Cristina
C
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008137:Longitudinal Studies; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015996:Survival Rate; D013997:Time Factors
D000975:Antioxidants; D008315:Malondialdehyde