title: Goat SRY induces testis development in XX transgenic mice.
abstract: The testis-determining gene SRY is not well-conserved among mammals, particularly between mouse and other mammals, both in terms of protein structure and of expression regulation. To evaluate SRY phylogenic conservation in regards to its function, we expressed the goat gene (gSRY) in XX transgenic mouse gonads. Here, we show that gSRY induces testis formation, despite a goat expression profile. Our results demonstrate that sex-reversal can be induced in XX-mice by a non-mouse SRY thus suggesting a conserved molecular mechanism of action of this testis-determining gene across mammalian species.
authors.affiliation: INRA, Biologie du Développement et Reproduction, Bât. J. Poly, 78350 Jouy-en-Josas, France.
authors.forename: Maëlle
authors.initials: M
authors.lastname: Pannetier
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Tilly
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kocer
authors.forename: Marthe
authors.initials: M
authors.lastname: Hudrisier
authors.forename: Lauriane
authors.initials: L
authors.lastname: Renault
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chesnais
authors.forename: José
authors.initials: J
authors.lastname: Costa
authors.forename: Fabienne
authors.initials: F
authors.lastname: Le Provost
authors.forename: Daniel
authors.initials: D
authors.lastname: Vaiman
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vilotte
authors.forename: Eric
authors.initials: E
authors.lastname: Pailhoux
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D003001:Cloning, Molecular; D012734:Disorders of Sex Development; D005260:Female; D015723:Gene Library; D006041:Goats; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D051876:Sex-Determining Region Y Protein / Q000235:genetics / Q000378:metabolism*; D013737:Testis / Q000254:growth & development* / Q000378:metabolism*; D014960:X Chromosome / Q000235:genetics*
chemical_list: D051876:Sex-Determining Region Y Protein