Constituents of Salvia microphylla.
A new phenolic ester 2-( p-hydroxyphenyl)ethyl eicosaheptanoic acid ester (1) and a known one hexacosylferulate (2) were isolated from the acetone extract of Salvia microphylla. In addition, two sesquiterpenes beta-eudesmol (3) and 8alpha-hydroxy-beta-eudesmol (4), a diterpene carnosic acid 12-methyl ether (12-methoxycarnosic acid) (5), three triterpenes erithrodiol 3-acetate, oleanolic acid, lupeol and beta-sitosterol were obtained as known compounds from this plant extract. The structures of the isolated compounds were elucidated by spectroscopic methods, including one- and two- dimensional 1H- and 13C-NMR and MS spectroscopies. The selected compounds were tested for antimicrobial activity against standard bacterial strains, and only carnosic acid 12-methyl ether showed antimicrobial activity against S. aureus at 78 microg mL(-1).
Aydogmuş
Zeynep
Z
Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Yeşilyurt
Volkan
V
Topcu
Gülaçti
G
D004952:Esters / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification*; D027544:Salvia / Q000737:chemistry*; D012855:Sitosterols / Q000302:isolation & purification; D013729:Terpenes / Q000302:isolation & purification*
C513846:2-(4-hydroxyphenyl)ethyl eicosaheptanoic acid ester; D004952:Esters; D010636:Phenols; D012855:Sitosterols; D013729:Terpenes; C025473:gamma-sitosterol