Fluorescein angiographic features of the congenital hypertrophy of the retinal pigment epithelium in the familial adenomatous polyposis.
OBJECTIVE
To asses the prevalence of fluorescein angiographic features in bilateral and multifocal Congenital Hypertrophy of the Retinal Pigment Epithelium (CHRPE) in patients with a diagnosis of familial adenomatous polyposis.


METHODS
We performed prospective angiographic and clinical examination of 49 CHPRE lesions in 15 patients.


RESULTS
About 77.5% of CHRPE lesions were close to retinal vessels. The retinal vascular changes observed overlying and surrounding the CHRPE were: capillary non-perfusion with an area greater than 0.5 disc diameters (41%), capillary microaneurysms (4%), chorioretinal anastomoses (6.2%), attenuation of retinal vessels (4%), choriocapillary vessels inside the lacunae (6.2%) and in the depigmented marginal halo (18.4%). Depigmented streaks in contact with one or both edges of the CHRPE were observed in 79.6% of the lesions. About 9.6% of the lesions were not seen on ophthalmoscopy and could only be detected by angiography.


CONCLUSIONS
Even though the diagnosis of CHRPE is clinical, fluorescein angiography may be useful in confirming the diagnosis, as well as detecting additional lesions not seen by means of ophthalmoscopic examination.
Touriño
Rosario
R
Department of Ophthalmology, School of Medicine of Santiago de Compostela, Complejo Hospitalario Universitario de Santiago-Hospital de Conxo, R/Ramón Baltar s/n. 15.706, Santiago de Compostela, La Coruña, Spain. rtourinop@msn.com
Rodríguez-Ares
M Teresa
MT
López-Valladares
M J
MJ
Gómez-Ulla
Francisco
F
Gómez-Torreiro
Manuel
M
Capeans
Carmen
C
D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D006984:Hypertrophy / Q000150:complications / Q000151:congenital / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000150:complications / Q000151:congenital* / Q000473:pathology