PI3K and RAC signalling in leukocyte and cancer cell migration.
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell migration are phosphoinositide 3-kinase (PI3K) and the Rho family of small GTPases. While PI3K activity defines the leading edge of the cell, Rho family GTPases regulate the cytoskeletal remodelling during polarisation and migration. We review here briefly the roles of PI3K, of the Rho-family GTPase Rac, and of the guanine-nucleotide exchange factors that activate Rac, in leukocyte and cancer cell migration.
Barber
Mark A
MA
Inositide Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK.
Welch
Heidi C E
HC
D000199:Actins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D058534:Class I Phosphatidylinositol 3-Kinases; D003599:Cytoskeleton / Q000502:physiology; D018450:Disease Progression; D020558:GTP Phosphohydrolases / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D051379:Mice; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction; D020744:rac GTP-Binding Proteins / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D058534:Class I Phosphatidylinositol 3-Kinases; D020558:GTP Phosphohydrolases; D020662:Guanine Nucleotide Exchange Factors; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011506:Proteins; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; C489234:MTMR12 protein, human; C484760:PIK3CA protein, human