title: 2,3-disubstituted benzofuran and indole by copper-mediated C-C bond extension reaction of 3-zinciobenzoheterole.
abstract: [reaction: see text] A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl(2) produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-disubstituted benzofurans and indoles.
authors.affiliation: Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Japan. masaharu@scl.kyoto-u.ac.jp
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Laurean
authors.initials: L
authors.lastname: Ilies
authors.forename: Saika
authors.initials: S
authors.lastname: Otsubo
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura