[Thyroid hormones and the cardiomyocytes].
The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.
Gatnar
Aleksander
A
The Second Department of Internal Medicine with Subdepartment of Endocrinology and Diabetology, Voivodeship Specialistic Hospital No. 3, Rybnik.
Marek
Bogdan
B
Pakuła
Dorota
D
Kajdaniuk
Dariusz
D
Kos-Kudła
Beata
B
Borgiel-Marek
Halina
H
Gnot
Roman
R
Pakuła
Piotr
P
Pawłowska
Magdalena
M
D000818:Animals; D006980:Hyperthyroidism / Q000503:physiopathology*; D007037:Hypothyroidism / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000096:biosynthesis; D013963:Thyroid Hormones / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood / Q000494:pharmacology
D013963:Thyroid Hormones; D014284:Triiodothyronine; D018995:Myosin Heavy Chains