Current status of dosing and quantification of acute renal replacement therapy. Part 2: dosing paradigms and clinical implementation.
The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically-ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance-related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examined the factors affecting the delivery of prescribed acute renal replacement therapy dose. Part 2 summarises and contextualises findings from recent dose-outcome studies, and reviews clinical tools to assist in the prescription and quantification of acute renal replacement therapy dose.
Marshall
Mark R
MR
Middlemore Hospital, Auckland, New Zealand. mrmarsh@woosh.co.nz
D058186:Acute Kidney Injury / Q000473:pathology* / Q000628:therapy* / Q000652:urine; D006801:Humans; D007700:Kinetics; D017582:Renal Replacement Therapy / Q000379:methods*; D015996:Survival Rate; D016896:Treatment Outcome