Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
Two new metabolites named 6-oxo-de-O-methyllasiodiplodin (1) and (E)-9-etheno-lasiodiplodin (2), with three known compounds lasiodiplodin (3), de-O-methyllasiodiplodin (4), and 5-hydroxy-de-O-methyllasiodiplodin (5), were isolated from the mycelium extracts of a brown alga endophytic fungus (No. ZZF36) obtained from the South China Sea. Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. Additionally, the structure of compound 1 was confirmed by single crystal X-ray diffraction analysis. The antimicrobial activities of lasiodiplodins, and the 13-acetyl and 12,14-dibromo derivatives of lasiodiplodin were tested for the first time and the results were compared to each other.
Yang
Rui-yun
RY
School of Chemistry and Chemical Engineering, Sun Yat-sen (Zhongshan) University, Guangzhou, PR China.
Li
Chun-yuan
CY
Lin
Yong-cheng
YC
Peng
Guang-tian
GT
She
Zhi-gang
ZG
Zhou
Shi-ning
SN
D000890:Anti-Infective Agents / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008024:Ligands; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D000459:Phaeophyceae; D010936:Plant Extracts / Q000378:metabolism; D014961:X-Ray Diffraction
D000890:Anti-Infective Agents; D007783:Lactones; D008024:Ligands; D018942:Macrolides; D010936:Plant Extracts; C558290:de-O-methyllasiodiplodin