An analysis for a cross-over cohort study with an application to the study of triggers of Menière's disease.
When studying the effect of a transient exposure on the risk of a rare illness, for time and cost effectiveness it is desirable to follow a cohort of individuals who are 'prone' to the illness over an observation period. In this paper, we present a method of analysis for data arising from such a study. The proposed method can be used to estimate the relative risk of an exposure triggering the illness and the distribution of the time delay from exposure to the onset of illness. The model is extended to include covariate effects and to the situation where there are two types of exposure. For the two types of exposures situation, a model to handle a possible synergism of the exposures is proposed. Finally, the method is applied to study the potential triggers of attacks of Menière's disease.
Salim
Agus
A
Centre for Mental Health Research, Australian National University, Canberra, Australia. agus.salim@anu.edu.au
Becker
Niels G
NG
Möller
Jette
J
Hessén-Söderman
Anne-Charlotte
AC
D000208:Acute Disease; D015331:Cohort Studies; D018592:Cross-Over Studies; D006801:Humans; D016014:Linear Models; D008575:Meniere Disease / Q000209:etiology*; D018570:Risk Assessment