Intestinal neuronal dysplasia.
Intestinal neuronal dysplasia type B (IND B) is currently defined as a disease of the submucous plexus of the intestine. The aetiology of IND B remains largely obscure. The congenital origin of IND B is supposed; nevertheless, the findings of IND B associated with chronic intestinal obstruction support the notion that this disease could be caused by a reaction of the enteral nervous system to intestinal obstruction or inflammatory disease either in the fetal or the postnatal period. The treatment of IND type B has no unified concept of treatment. The ultimate clinical diagnosis of IND B should be based on a definitive histological diagnosis relating to clinical symptoms, the course of treatment and long-term follow-up of patients with this dysfunction of intestinal motility, despite the fact that no correlations of the clinical picture, radiological investigation and anorectal manometric studies with IND B have been found so far.
Skába
Richard
R
Department of Paediatric Surgery, 2nd Medical Faculty of the Charles University in Prague and Motol University Hospital, Prague, Czech Republic. richard.skaba@lfmotol.cuni.cz
Frantlová
Miroslava
M
Horák
Jaromir
J
D000293:Adolescent; D001706:Biopsy; D002648:Child; D003248:Constipation / Q000209:etiology; D006801:Humans; D007415:Intestinal Obstruction / Q000150:complications; D013368:Submucous Plexus / Q000002:abnormalities* / Q000473:pathology