d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference.
d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction.
Botreau
Fanny
F
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP-A-244, 7141 Sherbrooke Street West, Montreal, Que., Canada H4B 1R6.
Paolone
Giovanna
G
Stewart
Jane
J
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans
D000963:Antimetabolites; D003523:Cycloserine; D003042:Cocaine