Challenging the role of microtubules in Tobacco mosaic virus movement by drug treatments is disputable.
The movement protein (MP) of Tobacco mosaic virus interacts with microtubules during infection. Although this interaction is correlated with the function of MP in the cell-to-cell transport of viral RNA, a direct role of microtubules in the movement process was recently challenged by studies involving the treatment of plants with inhibitors of microtubule polymerization. Here, we report evidence suggesting that such treatments may not efficiently disrupt all microtubules. Thus, results obtained from studies using microtubule inhibitors may have to remain open to interpretation with regard to the involvement of microtubules in viral RNA trafficking.
Seemanpillai
Mark
M
Institut Biologie Moléculaire des Plantes, 12 Rue du Général Zimmer, 67084 Strasbourg Cedex, France.
Elamawi
Rabab
R
Ritzenthaler
Christophe
C
Heinlein
Manfred
M
D017360:Arabidopsis / Q000235:genetics; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects / Q000235:genetics; D008870:Microtubules / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D053830:Plant Viral Movement Proteins; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D012367:RNA, Viral / Q000378:metabolism*; D014026:Nicotiana / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000235:genetics / Q000378:metabolism*; D014404:Tubulin / Q000235:genetics / Q000378:metabolism; D050257:Tubulin Modulators / Q000494:pharmacology*; D014764:Viral Proteins
D029681:Arabidopsis Proteins; D053830:Plant Viral Movement Proteins; D012367:RNA, Viral; D014404:Tubulin; D050257:Tubulin Modulators; D014764:Viral Proteins