title: Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management.
abstract: A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode = 7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.
authors.affiliation: Department of Psychology, University of Washington, Seattle, Washington, 98195-1525, Box 351525, USA. jsimoni@u.washington.edu
authors.forename: Jane M
authors.initials: JM
authors.lastname: Simoni
authors.forename: Ann E
authors.initials: AE
authors.lastname: Kurth
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Pearson
authors.forename: David W
authors.initials: DW
authors.lastname: Pantalone
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Merrill
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Frick
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D019468:Disease Management; D017408:Guidelines as Topic; D006801:Humans; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012650:Self Disclosure
chemical_list: D044966:Anti-Retroviral Agents