[Wilson's principles--a base of modern teratology].
Wilson's principles were formulated after thalidomide tragedy. They become a fundamental for teratological studies with drugs and other factors that may disturb fetal development. It is postulated that susceptibility to teratogen depends on the genotype and developmental stage of the conceptus. Teratogenic agents act in specific manner on developing cells and tissues. The exposition depends on the agent's nature and availability. Manifestations of deviant development depends on the dosage and exposure frequency. In case of abnormal development the final manifestations include death of embryo or fetus, malformation, growth retardation and functional disorder.
Burdan
Franciszek
F
Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka. fb3@wp.pl
Bełzek
Artur
A
Szumiło
Justyna
J
Dudka
Jarosław
J
Korobowicz
Agnieszka
A
Tokarska
Edyta
E
Klepacz
Lidia
L
Bełzek
Marta
M
Klepacz
Robert
R
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005838:Genotype; D006801:Humans; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D011817:Rabbits; D051381:Rats; D013723:Teratogens / Q000633:toxicity*; D018600:Teratology / Q000639:trends*; D013997:Time Factors
D013723:Teratogens