title: Acute symptomatic seizures and hippocampus damage: DWI and MRS findings.
abstract: The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with corresponding lactate detected on MRS in six patients and EEG seizure activity in nine patients. On follow-up, the atrophic hippocampus had an increased ADC in six patients. DWI and MRS may predict development of hippocampal sclerosis.
authors.affiliation: Department of Neuroradiology, National Neuroscience Institute, Singapore.
authors.forename: Hemant
authors.initials: H
authors.lastname: Parmar
authors.forename: Shih-Hui
authors.initials: SH
authors.lastname: Lim
authors.forename: Nigel C K
authors.initials: NC
authors.lastname: Tan
authors.forename: C C Tchoyoson
authors.initials: CC
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000175:diagnosis; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012640:Seizures / Q000150:complications* / Q000175:diagnosis*