title: High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.
abstract: Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals.
authors.affiliation: The Department of Chemistry, Vanderbilt University, Nashville, TN 37235-1822, USA. iand@femto.cas.vanderbilt.edu
authors.forename: Ian D
authors.initials: ID
authors.lastname: Tomlinson
authors.forename: John N
authors.initials: JN
authors.lastname: Mason
authors.forename: Randy D
authors.initials: RD
authors.lastname: Blakely
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Rosenthal
mesh_terms: D019921:Biotinylation; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D045663:Quantum Dots
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D004298:Dopamine