The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans.
Our goal was to explore associations between ss2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively (p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.
Lima
John J
JJ
The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA. Jlima@nemours.org
Holbrook
Janet T
JT
Wang
Jianwei
J
Sylvester
James E
JE
Blake
Kathryn V
KV
Blumenthal
Malcolm N
MN
Castro
Mario
M
Hanania
Nicholas
N
Wise
Robert
R
D000328:Adult; D001741:Black or African American; D001249:Asthma / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D009765:Obesity; D020641:Polymorphism, Single Nucleotide; D016032:Randomized Controlled Trials as Topic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012129:Respiratory Function Tests; D012737:Sex Factors; D012907:Smoking; D044465:White People
D018343:Receptors, Adrenergic, beta-2