title: Enterobacterial autoinducer of growth enhances shiga toxin production by enterohemorrhagic Escherichia coli.
abstract: The addition of the enterobacterial autoinducer of growth to nutrient-poor minimal medium markedly accelerated the exponential growth rates of strains of enterohemorrhagic Escherichia coli but had little or no effect on maximal cell densities in stationary phase. Growth in the presence of the autoinducer resulted in an approximately twofold enhancement in Shiga toxin production.
authors.affiliation: Robert Koch Institut, Wernigerode, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Voigt
authors.forename: A
authors.initials: A
authors.lastname: Fruth
authors.forename: H
authors.initials: H
authors.lastname: Tschäpe
authors.forename: R
authors.initials: R
authors.lastname: Reissbrodt
authors.forename: P H
authors.initials: PH
authors.lastname: Williams
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D003470:Culture Media / Q000737:chemistry; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D019453:Escherichia coli O157 / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000382:microbiology*; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D012694:Serine / Q000378:metabolism; D022603:Shiga Toxins / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D022603:Shiga Toxins; D012694:Serine; C030654:N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone; D015107:4-Butyrolactone; D009638:Norepinephrine