Endocytosis, endosome trafficking, and the regulation of Drosophila development.
Endocytosis and endosome trafficking regulate cell signaling in unexpected ways. Here we review the contribution that Drosophila research has made to this exciting field. In addition to attenuating signaling, endocytosis shapes morphogen gradients, activates ligands, and regulates spatially receptor activation within a single cell. Moreover, some receptors signal from within endosomes, and the ability of a specific type of endosome to form controls the ability of cells to signal. Experiments in Drosophila reveal that through regulation of a variety of cell signaling pathways, endocytosis controls cell patterning and cell fate.
Fischer
Janice A
JA
Institute for Cellular and Molecular Biology, Section of Molecular Cell and Development, University of Texas, Austin, Texas 78712, USA. jaf@mail.utexas.edu
Eun
Suk Ho
SH
Doolan
Benjamin T
BT
D000818:Animals; D001692:Biological Transport; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction
D051880:Receptors, Notch