A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic gamma-tocopherol derivative compared with alpha-tocopherol.
The antioxidant function of vitamin E is thought to mediate its photo-protective effects. Cyclooxygenase-2 (COX-2) is an important mediator of early photo-inflammation. Thus, the ability of gamma-tocopherol to inhibit COX-2 activity independently of its antioxidant function raises important questions regarding potential roles that this form of vitamin E plays in photo-protection and skin cancer chemoprevention.
Konger
Raymond L
RL
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. rkonger@iupui.edu
D000284:Administration, Oral; D000287:Administration, Topical; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D051546:Cyclooxygenase 2 / Q000502:physiology; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000502:physiology; D004817:Epidermis / Q000737:chemistry / Q000503:physiopathology / Q000528:radiation effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology*; D008027:Light / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D014466:Ultraviolet Rays / Q000009:adverse effects; D024502:alpha-Tocopherol / Q000494:pharmacology / Q000627:therapeutic use*; D024504:gamma-Tocopherol / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D052246:Cyclooxygenase 2 Inhibitors; D024504:gamma-Tocopherol; D051546:Cyclooxygenase 2; D024502:alpha-Tocopherol; D015232:Dinoprostone