title: [Influenza diagnostics in patient with leukemia suspicion].
abstract: Influenza is a seasonal viral disease, with the peak of morbidity occurring in Poland between January and March. It is estimated that up to 70% of respiratory infections during the season is caused by this virus. Influenza virus infection poses an ultimate threat to the elderly > or = 65 years old and chronically ill, in whom postinfluenzal complications--including viral pneumonia and secondary bacterial pneumonia--cause from 0.1% to 0.4% deaths annually. Influenza also triggers off from 5% to 7% cases of nosocomial infections in these patients. Among three influenza types being human pathogens only influenza A and B have clinical and diagnostic significance. Type C causes mild respiratory infections, usually in children. Out of the viruses circulating in our region the most pathogenic is A/H3N2 subtype that causes more severe infections, an increased number of hospitalizations and higher mortality than A/ H1N1 or B viruses. Lack of pathognomonic symptoms makes difficult a case definition-based diagnosis and draws an attention to key role of laboratory diagnostics for respiratory infections. It has an essential significance in high-risk patients not vaccinated against influenza giving an opportunity to use antiviral drugs of the new generation as oseltamivir.
authors.affiliation: Państwowy Zakład Higieny, Krajowy Ośrodek ds. Grypy w Warszawie. nic@pzh.gov.pl
authors.forename: Lidia B
authors.initials: LB
authors.lastname: Brydak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gawryluk
authors.forename: Grazyna
authors.initials: G
authors.lastname: Lietzau
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wiatr
authors.forename: Magdalena
authors.initials: M
authors.lastname: Machała
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000150:complications / Q000175:diagnosis*; D008297:Male; D053139:Oseltamivir
chemical_list: D000081:Acetamides; D000998:Antiviral Agents; D053139:Oseltamivir