Hereditary hemochromatosis: a review of the genetics, mechanism, diagnosis, and treatment of iron overload.
Hereditary hemochromatosis is a relatively common genetic disorder characterized by excess dietary iron absorption and deposition in tissues with resulting end-organ damage. Early diagnosis and initiation of therapeutic phlebotomy can provide a normal life expectancy for affected individuals.
Wheeler
Cathrine J
CJ
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Kowdley
Kris V
KV
D005838:Genotype; D006432:Hemochromatosis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics*; D018962:Phlebotomy
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D007501:Iron