Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia.
Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
Vaquero Lorenzo
Concepcion
C
Department of Genetics, Autonoma University of Madrid, Edificio de Biología, Facultad de Ciencias, Calle Darwin, 2. 28049, Cantoblanco, Madrid, Spain.
Baca-Garcia
Enrique
E
Diaz-Hernandez
Montserrat
M
Botillo-Martin
Carlota
C
Perez-Rodriguez
M Mercedes
MM
Fernandez-Ramos
Carolina
C
Saiz-Gonzalez
M Dolores
MD
Quintero-Gutierrez
Francisco J
FJ
Saiz-Ruiz
Jeronimo
J
Fernandez Piqueras
Jose
J
Gonzalez de Rivera
Jose Luis
JL
de Leon
Jose
J
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D013030:Spain / Q000453:epidemiology
D044402:Receptor, Serotonin, 5-HT2A; D004247:DNA