Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates.
Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones.
Samanta
Sampak
S
Department of Chemistry, University of Texas at San Antonio, Texas 78249-0698, USA.
Zhao
Cong-Gui
CG
D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D006880:Hydroxy Acids / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004791:Enzyme Inhibitors; D006880:Hydroxy Acids; D063065:Organophosphonates