title: Effect of meso-dihydroguaiaretic acid from Machilus thunbergii Sieb et Zucc on MMP-1 expression in heat shock-induced cultured primary human fibroblasts.
abstract: Ethanol and aqueous extracts of Machilus thunbergii Sieb et Zucc (Lauraceae) used traditionally for the treatment of a variety of diseases were screened in vitro for MMP-1 inhibitory actions. Meso-dihydroguaiaretic acid (MDGA) from the stem bark of M. thunbergii showed a significant inhibition of matrix metalloproteinase (MMP)-1 in primary human fibroblasts by heat shock-induced. This study investigated the effect of MDGA isolated from M. thunbergii on heat shock-induced premature skin aging. MDGA reduced the expression of MMP-1 at the protein level in a dose-dependent manner in heat shock-induced cultured primary human fibroblasts. Taken together, these results show that MDGA can prevent the harmful effects of heat (and/or IR) that lead to skin aging.
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi 38677, USA. himoon@olemiss.edu
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Hyungin
authors.initials: H
authors.lastname: Moon
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Jung
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D018869:Heat-Shock Response / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D019770:Lauraceae / Q000737:chemistry; D017705:Lignans / Q000494:pharmacology*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D017705:Lignans; D010936:Plant Extracts; C015816:dihydroguaiaretic acid; D006139:Guaiacol; D020781:Matrix Metalloproteinase 1