Total synthesis and cytotoxicity evaluation of syrinenin-4-O-farnesylether and its analogues.
First synthesis of natural product, syrinenin-4-O-farnesylether (1), was carried out via two different paths. Four of its derivatives (9-12) were also prepared. Cytotoxicity screening of the selected compounds were performed on six tumour cell lines. Compound 12 exhibited prominent IC50 values of 1.9 microM and 0.8 microM on CNE and PC-3 cells, respectively.
Zou
Hong-Bin
HB
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Gong
Jing-Xu
JX
Li
Hai-Bo
HB
Yang
Lei-Xiang
LX
Hu
Li-Hong
LH
Zhou
Chang-Xin
CX
Wu
Xiu-Mei
XM
Dou
Hui
H
Zhao
Yu
Y
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D019659:Asteraceae / Q000737:chemistry; D045744:Cell Line, Tumor; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure
D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; D004987:Ethers; C511994:syrinenin-4-O-farnesylether