title: Approximate variance for a standardized composite measure of linkage disequilibrium.
abstract: The approximate variance for the standardized measure of gametic linkage disequilibrium has been described. However, this approach assumes knowledge of the phase of double heterozygotes or Hardy-Weinberg equilibrium. Here we give the approximate variance for a composite measure of linkage disequilibrium which depends only on genotype frequencies. We show by simulation that this variance approximation is valid over a range of allele probabilities and departures from Hardy-Weinberg equilibrium.
authors.affiliation: Department of Mathematics and Statistics, Dalhousie University, Halifax, Canada.
authors.forename: D C
authors.initials: DC
authors.lastname: Hamilton
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: D E C
authors.initials: DE
authors.lastname: Cole
mesh_terms: D000704:Analysis of Variance; D002874:Chromosome Mapping; D003198:Computer Simulation; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D012015:Reference Standards