title: Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung.
abstract: A 55-year-old man, diagnosed with systemic sclerosis (SSc) for 20 years, was admitted to our hospital for exertional dyspnea and pleural effusion. Computed tomography scan and cytological findings of the pleural fluid suggested malignant mesothelioma. In the postmortem examination, the tumor was pathologically diagnosed as pseudomesotheliomatous adenocarcinoma (PMA) of the lung, classified into pleomorphic carcinoma with adenocarcinoma component according to the new World Health Organization guidelines. This is the first case report of SSc with PMA.
authors.affiliation: Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. yoshiryu@med.yokohama-cu.ac.jp
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Yoshimi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takeno
authors.forename: Shoji
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shiina
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kirino
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takeda
authors.forename: Akiko
authors.initials: A
authors.lastname: Sekiguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ihata
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Motoji
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ohno
authors.forename: Atsuhisa
authors.initials: A
authors.lastname: Ueda
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Soga
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D001344:Autopsy; D003584:Cytological Techniques; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis; D008875:Middle Aged; D018301:Neoplasms, Mesothelial / Q000175:diagnosis; D016066:Pleural Effusion, Malignant / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000150:complications*; D014057:Tomography, X-Ray Computed