title: Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia.
abstract: OBJECTIVE
  Obesity is a risk factor for pre-eclampsia, and adiponectin is an important adipocyte-derived hormone that might protect the endothelium. Recent reports have underlined importance of circulating angiogenic factors for pathophysiology of pre-eclampsia. Here we examined whether adiponectin in conjunction with angiogenic factors plays some roles in the pathophysiology of pre-eclampsia.
  
  
  METHODS
  We measured serum concentrations of adiponectin and angiogenic factors, vascular endothelial growth factor, placental growth factor, and the soluble vascular endothelial growth factor receptors, soluble fms-like tyrosine Kinase 1 (sFlt-1) and soluble fetal liver kinase 1 (sFlk-1), in women with pre-eclampsia and healthy pregnant women. We also investigated the differences of these factors in overweight and normal-weight patients with pre-eclampsia.
  
  
  RESULTS
  Significant correlations were found among the circulating adiponectin and angiogenic factors placental growth factor (R = 0.772, P = .0012) and sFlt-1 (R = 0.787, P = .0005); while, no correlation was found between adiponectin and sFlk-1 (R = 0.3, P = .3434) in patients with pre-eclampsia. Overweight patients with pre-eclampsia showed significantly lower adiponectin levels and a mild imbalance of circulating angiogenic factors, compared with normal-weight patients with pre-eclampsia.
  
  
  CONCLUSIONS
  Overweight women with pre-eclampsia appeared to have lower levels of adiponectin and sFlt1 and higher levels of placental growth factor than women with pre-eclampsia who were of normal weight. These results suggest that hypoadiponectinemia might be involved in the pathophysiology of overweight patients with pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Suwaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Masuyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakatsukasa
authors.forename: Akio
authors.initials: A
authors.lastname: Masumoto
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sumida
authors.forename: Norio
authors.initials: N
authors.lastname: Takamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiramatrsu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D050177:Overweight; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D040262:Receptors, Vascular Endothelial Growth Factor / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood
chemical_list: D052242:Adiponectin; D042501:Angiogenic Proteins; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040262:Receptors, Vascular Endothelial Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2