title: Staphylococcus aureus carriage patterns and the risk of infections associated with continuous peritoneal dialysis.
abstract: The epidemiology and risks of Staphylococcus aureus carriage in continuous peritoneal dialysis (CPD) patients was studied in a single tertiary-care institution. On outpatient visits samples for culture were routinely taken prospectively from the CPD catheter exit site and the vestibulum nasi. Seventy-five patients with at least one culture positive for S. aureus in this period were included: 43 had genotypically identical S. aureus strains in over 80% of the cultures and were classified as persistent carriers; 32 were intermittent carriers. Persistent carriage was associated with a threefold higher risk for CPD-related infections and sixfold higher rates of vancomycin consumption compared to those for the intermittent carriers. No methicillin or vancomycin resistance was detected.
authors.affiliation: Department of Medical Microbiology & Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands. j.l.nouwen@erasmusmc.nl
authors.forename: Jan
authors.initials: J
authors.lastname: Nouwen
authors.forename: Jeroen
authors.initials: J
authors.lastname: Schouten
authors.forename: Peter
authors.initials: P
authors.lastname: Schneebergen
authors.forename: Susan
authors.initials: S
authors.lastname: Snijders
authors.forename: Jolanda
authors.initials: J
authors.lastname: Maaskant
authors.forename: Marjan
authors.initials: M
authors.lastname: Koolen
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
authors.forename: Henri A
authors.initials: HA
authors.lastname: Verbrugh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000382:microbiology; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*