title: Pulmonary sarcoidosis and antiphospholipid syndrome.
abstract: Various autoimmune diseases have been reported to occur in patients with sarcoidosis. However, coexistence of sarcoidosis and antiphospholipid syndrome (APS) is extremely rare. We describe a 59-year-old female patient with pulmonary sarcoidosis who had preceding APS. Her previous medical history consisted of a miscarriage and ischemic colitis. She was diagnosed as APS during the onset of a brainstem infarction with positive reaction to beta2-glycoprotein I-dependent anticardiolipin antibody. Two years later, chest CT revealed enlargement of the hilar and mediastinal lymph nodes and small nodules in the lung fields. Transbronchial lung biopsy demonstrated non-caseating epithelioid cell granuloma leading to the diagnosis of definite pulmonary sarcoidosis. This is the first APS case where pulmonary involvement with sarcoidosis has been confirmed through lung biopsy. Our case report suggests that APS should be recognized as an accompanying disorder of sarcoidosis.
authors.affiliation: Department of Respiratory Medicine, Juntendo University, School of Medicine, Hongo, Tokyo, Japan. fumiyuki@med.juntendo.ac.jp
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Takahashi
authors.forename: Michie
authors.initials: M
authors.lastname: Toba
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tominaga
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Morio
authors.forename: Yuta
authors.initials: Y
authors.lastname: Nakao
authors.forename: Ken
authors.initials: K
authors.lastname: Tajima
authors.forename: Kayo
authors.initials: K
authors.lastname: Miura
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uekusa
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Fukuchi
mesh_terms: D000554:Ambulatory Care Facilities; D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000276:immunology; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D053482:beta 2-Glycoprotein I
chemical_list: D006023:Glycoproteins; D053482:beta 2-Glycoprotein I