Hassallidin B--second antifungal member of the Hassallidin family.
The cyanobacterium Hassallia sp. produces a family of four compounds which exhibit a broad spectrum of antifungal activities. So far only one of these members has been isolated and its structure elucidated. In this study, we present a second member of this group. Mass spectrometry, one- and two-dimensional NMR and chiral GC-MS analysis revealed the same peptidic and fatty acid core for hassallidin B as the first member hassallidin A with an additional carbohydrate unit, a rhamnose attached to the 3-hydroxyl group of the C(14)-acyl side chain. The antifungal potential of hassallidin B is nearly identical to that of hassallidin A.
Neuhof
Torsten
T
Technische Universität Berlin, Fak. II, Institut für Chemie, Berlin, Germany.
Schmieder
Peter
P
Seibold
Michael
M
Preussel
Karina
K
von Döhren
Hans
H
D000935:Antifungal Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D000458:Cyanobacteria / Q000378:metabolism; D015195:Drug Design; D008401:Gas Chromatography-Mass Spectrometry; D006017:Glycolipids / Q000737:chemistry* / Q000494:pharmacology; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D006017:Glycolipids; D006020:Glycopeptides; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; C501712:hassallidin A; C513949:hassallidin B