Precocious puberty due to human chorionic gonadotropin-secreting pineal tumor.
We present a 9-year-old boy with central precocious puberty and hydrocephalus caused by a human chorionic gonadotropin (beta-hCG) secreting pineal tumor. High levels of beta-hCG in the serum and cerebrospinal fluid were observed in this patient. The patient received radiotherapy and chemotherapy without surgical intervention. Subsequently, significant tumor regression was observed and the serum beta-hCG level normalized. There was no evidence of tumor recurrence at follow-up one year after treatment. The role of tissue biopsy to establish a diagnosis in pineal germ cell tumors remains controversial because it can be a difficult procedure and may be dangerous, causing severe complications. In this patient, the elevated beta-hCG level indicated the presence of a tumor and was considered sufficient evidence to warrant initiating treatment.
Kuo
Ho-Chang
HC
Division of Hematology/Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Kaohsiung, Taiwan.
Sheen
Jiunn-Ming
JM
Wu
Kuan-Sheng
KS
Wei
Hsiu-Hui
HH
Hsiao
Chih-Cheng
CC
D001932:Brain Neoplasms / Q000150:complications* / Q000628:therapy; D002648:Child; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D010870:Pineal Gland; D011629:Puberty, Precocious / Q000209:etiology*
D018997:Chorionic Gonadotropin, beta Subunit, Human