Drug delivery system based on covalently bonded poly[N-isopropylacrylamide-co-2-hydroxyethylacrylate]-based nanoparticle networks.
The present work is focused on investigating the controlled drug release behavior of Poly [N-isopropylacrylamide-co-2-Hydroxyethylacrylate] (P [NIPAm-HEAc])-based hydrogel. The synthesis process includes the preparation of monodispersed hydrogel nanoparticles containing specific functional groups, followed by cross-linking to neighboring spheres to stabilize the entire network. The color and volume of these crystalline hydrogel networks can reversibly change in response to external stimuli such as temperature, pH, and other environmental conditions. The feasibility of the hydrogel as a controlled release vehicle for 5-fluorouracil is evaluated.
Mathews
Anu Stella
AS
Department of Polymer Science and Engineering, Pusan National University, Jangjeon-dong, Busan, Korea.
Ha
Chang-Sik
CS
Cho
Won-Jei
WJ
Kim
Il
I
D000179:Acrylates / Q000737:chemistry*; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D005472:Fluorouracil / Q000737:chemistry; D006358:Hot Temperature; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D000179:Acrylates; D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D020100:Hydrogels; D011108:Polymers; C512392:poly(N-isopropylacrylamide-co-2-hydroxyethylacrylate); D005472:Fluorouracil