title: Influence of initiator and different polymerisation conditions on performance of molecularly imprinted polymers.
abstract: A set of polymers was imprinted with (-)-ephedrine using two different initiators. A chemometrics approach was used to optimise experiments aimed at analysis of the interplay of parameters such as polymerisation time, temperature and percentage of initiator. The results presented demonstrate the importance of keeping the right balance between these various parameters of polymerisation conditions. It is shown that enhancing one single parameter such as polymer rigidity does not necessarily improve polymer performance. In general it could be concluded that MIPs should be synthesised over a long period of time using low concentration of initiator and low temperature. The best selectivity was achieved for polymers prepared by photo-initiation with 2,2-dimethoxy-2-phenylacetophenone as initiator.
authors.affiliation: Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK. i.mijangos.s03@cranfield.ac.uk
authors.forename: Irene
authors.initials: I
authors.lastname: Mijangos
authors.forename: Fernando
authors.initials: F
authors.lastname: Navarro-Villoslada
authors.forename: Antonio
authors.initials: A
authors.lastname: Guerreiro
authors.forename: Elena
authors.initials: E
authors.lastname: Piletska
authors.forename: Iva
authors.initials: I
authors.lastname: Chianella
authors.forename: Kal
authors.initials: K
authors.lastname: Karim
authors.forename: Anthony
authors.initials: A
authors.lastname: Turner
authors.forename: Sergey
authors.initials: S
authors.lastname: Piletsky
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000528:radiation effects; D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004809:Ephedrine / Q000737:chemistry*; D008422:Materials Testing; D010777:Photochemistry / Q000379:methods*; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects; D013499:Surface Properties; D013696:Temperature
chemical_list: D000098:Acetophenones; D001672:Biocompatible Materials; D011108:Polymers; D004809:Ephedrine