Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.
Thy-1 (CD90) is a 25-37 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on many cell types, including T cells, thymocytes, neurons, endothelial cells, and fibroblasts. Activation of Thy-1 can promote T cell activation, and this role of Thy-1 is reviewed elsewhere. Thy-1 also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death. In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis.
Rege
Tanya A
TA
The Department Cell Biology and Medical Scientist Training Program, The University of Alabama at Birmingham, VH 648A, 1670 University Blvd., Birmingham, Alabama 35294-0019, USA.
Hagood
James S
JS
D000818:Animals; D017209:Apoptosis; D001369:Axons / Q000502:physiology; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D051379:Mice; D009385:Neoplastic Processes; D009416:Nerve Regeneration; D018800:Thy-1 Antigens / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
D018800:Thy-1 Antigens; D025521:Tumor Suppressor Proteins