Cell biology: Ran, mitosis and the cancer connection.
The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer.
Sanderson
Helen S
HS
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK. h.s.sanderson@dundee.ac.uk
Clarke
Paul R
PR
D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism*; D014981:Xenopus; D029867:Xenopus Proteins / Q000378:metabolism / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000502:physiology*
C465041:DLGAP5 protein, human; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D029867:Xenopus Proteins; D020931:ran GTP-Binding Protein