Special concern about squamous cell carcinoma of the scalp in organ transplant recipients.
BACKGROUND
Several risk factors are generally accepted to portend more aggressive behavior of cutaneous squamous cell carcinoma. These include tumor size, tumor depth, histologic subtype, location on the lip or ear, tumor arising in scar, recurrent tumor, and tumor demonstrating perineural invasion. Organ transplant recipients can have significant morbidity and mortality from squamous cell carcinoma.


METHODS
Four organ transplant recipients developed metastatic disease from squamous cell carcinoma of the scalp.


CONCLUSIONS
Squamous cell carcinoma of the scalp in organ transplant recipients should be considered a high-risk tumor because of its anatomic location. Margin-controlled tumor extirpation, sentinel lymph node biopsy, and adjuvant radiation therapy should all be considered in the organ transplant recipient population.
Cooper
Jennifer Z
JZ
Department of Dermatology, University of Maryland, Baltimore, MD 21201, USA. jzcooper@som.umaryland.edu
Brown
Marc D
MD
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology