Life-long protein malnutrition in the rat (Rattus norvegicus) results in altered patterns of craniofacial growth and smaller individuals.
Dietary protein is a limiting factor in mammalian growth, significantly affecting the non-linear trajectories of skeletal growth. Young females may be particularly vulnerable to protein malnutrition if the restriction is not lifted before they become reproductive. With such early malnutrition, limited amino acids would be partitioned between two physiological objectives, successful reproduction vs. continued growth. Thus, the consequences of protein malnutrition could affect more than one generation. However, few studies have quantified these cross-generational effects. Our objective was to test for differences in skeletal growth in a second generation of malnourished rats compared with rats malnourished only post-weaning, the first generation and with controls. In this longitudinal study we modelled the growth of 22 craniofacial measurements with the logistic Gompertz equation, and tested for differences in the equation's parameters among the diet groups. The female offspring of post-weaning malnourished dams did not catch up in size to the first generation or to controls, although certain aspects of their craniofacial skeleton were less affected than others. The second generation's growth trajectories resembled the longer and slower growth of the first malnourished generation. There was a complex interaction between developmental processes and early nutritional environment, which affected variation of adult size.
Lobe
Shannon L
SL
Department of Biological Sciences, University of Cincinnati, USA.
Bernstein
Marica C
MC
German
Rebecca Z
RZ
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D049628:Body Size; D001835:Body Weight; D001846:Bone Development / Q000502:physiology; D005147:Facial Bones / Q000254:growth & development*; D005260:Female; D016015:Logistic Models; D008297:Male; D039401:Prenatal Nutritional Physiological Phenomena; D011502:Protein-Energy Malnutrition; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning