Primary hepatic invasive aspergillosis with progression after rituximab therapy for a post transplantation lymphoproliferative disorder.
We present a case of primary hepatic and possible splenic invasive aspergillosis (IA), which progressed under anti-CD20 B cell treatment for posttransplantation lymphoproliferative disease following allogeneic stem cell transplantation, to highlight the clinical value of a positive galactomannan-antigen test, an intestinal portal of entry of Aspergillus, and the detrimental effect of B lymphocyte depletion in IA.
van der Velden
W J F M
WJ
Blijlevens
N M A
NM
Klont
R R
RR
Donnelly
J P
JP
Verweij
P E
PE
D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects*; D058846:Antibodies, Monoclonal, Murine-Derived; D000935:Antifungal Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury; D017809:Fatal Outcome; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006086:Graft vs Host Disease / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008351:Mannans / Q000097:blood; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage; D000069283:Rituximab; D013158:Splenic Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects; D014184:Transplantation, Homologous; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D008351:Mannans; D011743:Pyrimidines; D014230:Triazoles; C012990:galactomannan; D000069283:Rituximab; D065819:Voriconazole; D005690:Galactose