title: Lymphoepithelioma-like carcinoma of the skin: a case with lymph node metastases at presentation.
abstract: We report a case of a primary lymphoepithelioma-like carcinoma (LELC) of the skin. The patient was a 73-year-old man with a lump on his back for 18 months. A biopsy and subsequent excision was performed. He also had axillary node clearance for metastatic disease. The tumor was composed of islands of pleomorphic cells with a lymphocytic infiltrate. Differential diagnoses included squamous cell carcinoma, adnexal carcinoma, Merkel cell tumors, lymphoepithelial lesions, lymphomas, and skin metastases. The histopathologic and immunohistochemical features were those of a LELC of the skin. It was negative for Epstein-Barr virus. Just over 30 cases of primary LELCs arising in the skin have been reported with only 1 documented fatality. We report a case with extensive vascular involvement and bilateral lymph node metastases.
authors.affiliation: Department of Pathology, Royal Liverpool and Broad Green University Hospital Trust, Liverpool, England.
authors.forename: Gillian
authors.initials: G
authors.lastname: Hall
authors.forename: Alison
authors.initials: A
authors.lastname: Duncan
authors.forename: Richard
authors.initials: R
authors.lastname: Azurdia
authors.forename: Niamh
authors.initials: N
authors.lastname: Leonard
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D015266:Carcinoma, Merkel Cell / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000601:surgery; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000601:surgery; D035583:Rare Diseases / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery