[Prevention of Rh (D) alloimmunization in Rh (D) negative women in pregnancy and after birth of Rh (D) positive infant].
OBJECTIVE
The objective of this review was to assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunization when given to Rh-negative women without anti-D antibodies and assess the effects of giving anti-D to Rhesus negative women, with no anti-D antibodies, who had given birth to a Rhesus positive infant.


METHODS
A review article.


METHODS
Department of Obstetrics and Gynecology, Department of Medical Genetics and Fetal Medicine, University Hospital, Olomouc, Ministry of Health, Czech Republic.


METHODS
We searched the Cochrane Pregnancy and Childbirth Group trials register, refence lists of relevant articles and bibliographies.


CONCLUSIONS
The risk of Rhesus D alloimmunization during or immediately after a first pregnancy is about 1%. Administration of 100 microg (500 IU) anti-D to women in their first pregnancy can reduce this risk to about 0.2% without, to date, any adverse effects. Anti-D, given within 72 hours after childbirth, reduces the risk of RhD alloimmunization in Rhesus negative women who have given birth to a Rhesus positive infant. However the evidence on the optimal dose is limited.
L'ubuský
M
M
Gynekologicko-porodnická klinika LF UP a FN, Olomouc. lubusky@email.cz
Procházka
M
M
Krejcová
L
L
Vetr
M
M
Santavý
J
J
Kudela
M
M
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011181:Postnatal Care; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000517:prevention & control*; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage*; D012307:Risk Factors
D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin