JC virus detection in bodily fluids: clues to transmission.
JC virus in saliva, oropharyngeal fluid, blood, and urine samples obtained from 58 human immunodeficiency virus-infected persons and 58 matched controls was investigated by performing quantitative polymerase chain reaction. JC virus was rarely present in oropharyngeal fluid and blood samples, even in those obtained from immunosuppressed individuals, but it was commonly detected in urine samples from both groups, suggesting that urine contributes to transmission.
Berger
Joseph R
JR
Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40536-0284, USA. jrbneuro@pop.uky.edu
Miller
Craig S
CS
Mootoor
Yunanan
Y
Avdiushko
Sergei A
SA
Kryscio
Richard J
RJ
Zhu
Hua
H
D000328:Adult; D000368:Aged; D012634:Bodily Secretions / Q000821:virology*; D001826:Body Fluids / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D005260:Female; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000635:transmission / Q000821:virology*