Effect of dopamine D1 receptor antagonist SCH23390 and D1 agonist A77636 on active allothetic place avoidance, a spatial cognition task.
Central dopamine neurotransmission is implicated in several physiological and pathophysiological neural processes. In the past years, attention was paid to the role of dopaminergic signaling in the cognitive processes. In the present study, we investigate role of dopamine D1 receptors in spatial cognition using systemic administration of D1-specific agonist A77636 and D1 antagonist SCH23390. Subsequently, animals were tested in a spatial cognition behavioral task, active allothetic place avoidance (AAPA), a task which requires rats to separate spatial stimuli from two continuously dissociated subsets. The D1 agonist A77636 at doses 0.1 and 0.5mg/kg improved the task solution, whilst application of D1 antagonist SCH23390 (0.02 and 0.05 mg/kg) caused an impairment in the AAPA task. These findings support the notion that brain dopaminergic D1 neurotransmitter system modulates neural processes underlying spatial cognition.
Stuchlik
Ales
A
Institute of Physiology, Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic. stuchlik@biomed.cas.cz
Vales
Karel
K
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001552:Benzazepines / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology*; D013028:Space Perception / Q000187:drug effects / Q000502:physiology; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology*; D018709:Statistics, Nonparametric
D001552:Benzazepines; D001578:Benzopyrans; D015259:Dopamine Agents; D017447:Receptors, Dopamine D1; C079415:A 77636; D000218:Adamantane