title: The concerted modulation of proliferation and migration contributes to the specification of the cytoarchitecture and dimensions of cortical areas.
abstract: Regionalization of cell cycle kinetics of cortical precursors has been described in nonhuman primates and rodents indicating a fate map of areas as distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas 17 and 18, which show striking cytoarchitectonic differences, as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating 2 areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration, and tangential expansion.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U371, Cerveau et Vision, Department of Stem Cell and Cortical Development, 69500 Bron, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Lukaszewicz
authors.forename: Véronique
authors.initials: V
authors.lastname: Cortay
authors.forename: Pascale
authors.initials: P
authors.lastname: Giroud
authors.forename: Michel
authors.initials: M
authors.lastname: Berland
authors.forename: Iain
authors.initials: I
authors.lastname: Smart
authors.forename: Henry
authors.initials: H
authors.lastname: Kennedy
authors.forename: Colette
authors.initials: C
authors.lastname: Dehay
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D000882:Haplorhini; D019579:Neocortex / Q000166:cytology* / Q000196:embryology* / Q000502:physiology; D009415:Nerve Net / Q000166:cytology* / Q000196:embryology* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D038081:Organogenesis / Q000502:physiology*