Pseudomyxoma peritonei arising from colonic polyps.
OBJECTIVE
Pseudomyxoma peritonei may have as its primary site a mucinous gastrointestinal adenoma or carcinoma that gains access to the peritoneal cavity. This manuscript describes this disease arising from a benign or malignant colonic polyp.


METHODS
From a database of over 1000 pseudomyxoma peritonei patients and colorectal carcinomatosis patients, three cases were identified in which the primary tumor site was a colonic polyp. The clinical history and course of these patients were studied.


RESULTS
In a review of the clinical management of these patients, all three had an event whereby neoplastic cells from the surface of the colonic polyp could have gained access to the free peritoneal cavity. The patients developed the characteristic pseudomyxoma peritonei syndrome. All three patients were treated with cytoreductive surgery plus perioperative hyperthermic intraperitoneal chemotherapy.


CONCLUSIONS
Colonic polyps can serve as a source of dysplastic cells whereby pseudomyxoma peritonei can result. Caution to prevent seeding to the free peritoneal cavity during surgery for colonic polyps should be observed. If pseudomyxoma peritonei develops, cytoreductive surgery and perioperative intraperitoneal chemotherapy should be considered for treatment.
Goldstein
P J G
PJ
Washington Cancer Institute, 106 Irving Street NW, Washington, DC 20010, USA.
Cabanas
J
J
da Silva
R G
RG
Sugarbaker
P H
PH
D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000601:surgery; D018253:Adenoma, Villous / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D003111:Colonic Polyps / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011553:Pseudomyxoma Peritonei / Q000209:etiology*