title: S100A7 (Psoriasin): a story of mice and men.
abstract: S100 proteins are calcium-regulated proteins that regulate fundamental biological processes. S100A7 (psoriasin), functions as a transglutaminase substrate/cornified envelope precursor, signal transduction protein, chemokine, and antibacterial protein in normal epidermis. S100A7 is markedly increased in epidermal hyperproliferative disorders. The murine homolog of S100A7 and S10015 has been identified, providing a valuable tool for studying the regulation and function of this protein in epidermis.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970, USA. rle2@po.cwru.edu
authors.forename: Richard L
authors.initials: RL
authors.lastname: Eckert
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Lee
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics* / Q000502:physiology; D004195:Disease Models, Animal; D004817:Epidermis / Q000502:physiology*; D050556:Fatty Acid-Binding Proteins / Q000032:analysis / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D051379:Mice; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000235:genetics; D012871:Skin Diseases / Q000503:physiopathology; D012878:Skin Neoplasms / Q000503:physiopathology
chemical_list: D002135:Calcium-Binding Proteins; C493412:FABP5 protein, human; D050556:Fatty Acid-Binding Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human; C510475:S100A7A protein, human; C506174:S100a7a protein, mouse