A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly.
A flow process for the multi-step synthesis of the alkaloid natural product (+/-)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.
Baxendale
Ian R
IR
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Deeley
Jon
J
Griffiths-Jones
Charlotte M
CM
Ley
Steven V
SV
Saaby
Steen
S
Tranmer
Geoffrey K
GK
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D047151:Amaryllidaceae Alkaloids; D001688:Biological Products; C424626:oxomaritidine