Ontogeny of ingestive behavior.
Review of the ontogeny of the controls of independent ingestion reveals that some of the direct and indirect controls of meal size identified in adult rats function in the first three postnatal weeks. The controls appear sequentially and some of them change their potency after they emerge. Indirect controls exerted by metabolism and adiposity do not emerge until the fourth postnatal week or later in the postweaning period. Recent experiments in rats with monogenic obesities involving the leptin and cholecystokinin receptors have demonstrated the usefulness of independent ingestion in the detection of the earliest expression of hyperphagia. Although much remains to be learned about the normal controls of independent ingestion, it is clear that it provides relevant information about the development of normal and abnormal controls of meal size in rodents that is useful for translational research into the controls of meal size in normal and obese children.
Smith
Gerard P
GP
Department of Psychiatry, Weill Medical College of Cornell University, Presbyterian Hospital, 21 Bloomingdale Road, White Plains, New York, New York 10605, USA. gpsmith@med.cornell.edu
D000818:Animals; D000831:Animals, Newborn; D002766:Cholecystokinin / Q000502:physiology; D003847:Deoxyglucose / Q000378:metabolism; D004298:Dopamine / Q000502:physiology; D002149:Energy Intake; D004777:Environment; D005246:Feedback / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D005508:Food Deprivation; D005947:Glucose / Q000031:analogs & derivatives / Q000378:metabolism; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000235:genetics; D010812:Physical Stimulation; D014630:Vagus Nerve / Q000502:physiology
D020738:Leptin; C003002:5-thio-D-glucose; D002766:Cholecystokinin; D003847:Deoxyglucose; D005947:Glucose; D004298:Dopamine