title: Role of laser energy density for photodynamic therapy of radiation injuries of the skin.
abstract: The role of different laser energy densities used in photodynamic therapy in the reparation of radiation ulcers caused by X-ray exposure in a dose of 80 Gy was studied. Tissue reparation manifested differently at different laser energy densities. After photodynamic therapy at energy density of 0.1 J/cm2 the rate of healing was notably higher during early periods. After exposure at 5 and 40 J/cm2 acceleration of ulcer healing was observed 14 and more days after the treatment, indicating the emergence of another mechanism of photodynamic therapy effect. Laser energy density of 5 J/cm2 was the most effective for maximally complete healing of radiation ulcers.
authors.affiliation: Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.
authors.forename: R G
authors.initials: RG
authors.lastname: Nikitina
authors.forename: M A
authors.initials: MA
authors.lastname: Kaplan
authors.forename: T G
authors.initials: TG
authors.lastname: Morozova
authors.forename: V V
authors.initials: VV
authors.lastname: Drozhzhina
authors.forename: T V
authors.initials: TV
authors.lastname: Epatova
authors.forename: E Yu
authors.initials: EY
authors.lastname: Luk'yanova
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D053685:Laser Therapy / Q000379:methods; D007834:Lasers; D010778:Photochemotherapy / Q000379:methods*; D011832:Radiation Injuries / Q000628:therapy*; D051381:Rats; D012867:Skin / Q000528:radiation effects*; D013997:Time Factors; D014945:Wound Healing; D014965:X-Rays