title: Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist.
abstract: Current knowledge on the opportunist Scedosporium apiospermum (teleomorph: Pseudallescheria boydii), generated over a period of more than 120 years, is reviewed. The natural environmental habitat of the fungus is unknown; nutrient-rich, brackish waters like river estuaria have been suggested. The fungus is strongly promoted by agricultural and particularly by industrial pollution.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.forename: A Serda
authors.initials: AS
authors.lastname: Kantarcioglu
authors.forename: Regine
authors.initials: R
authors.lastname: Horré
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Rodriguez-Tudela
authors.forename: Manuel
authors.initials: M
authors.lastname: Cuenca Estrella
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: G Sybren
authors.initials: GS
authors.lastname: de Hoog
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D025141:Drug Resistance, Fungal; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D008271:Mycetoma / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology*; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D021681:Scedosporium / Q000145:classification / Q000254:growth & development / Q000472:pathogenicity*
chemical_list: D000935:Antifungal Agents