title: NOS3 gene polymorphisms and exercise hemodynamics in postmenopausal women.
abstract: We tested whether the G894T and T-786C NOS3 polymorphisms were associated with exercise cardiovascular (CV) hemodynamics in sedentary, physically active, and endurance-trained postmenopausal women. CV hemodynamic parameters including heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressures and cardiac output (Q), as determined by acetylene rebreathing, stroke volume (SV), arteriovenous oxygen difference (a-vO2 diff), and total peripheral resistance (TPR) were measured during submaximal (40, 60, 80 %) and maximal (approximately 100 % VO2max) exercise. NOS3 G894T genotype was not significantly associated, either independently or interactively with habitual physical activity (PA) level, with SBP, Q, TPR, or a-vO2 diff during submaximal or maximal exercise. However, NOS3 894T non-carriers had a higher submaximal exercise HR than NOS3 894T allele carriers (120 +/- 2 vs. 112 +/- 2 beats/min, p = 0.007). NOS3 894T allele carriers had a higher SV than 894T non-carriers (78 +/- 2 vs. 72 +/- 2 ml/beat, p = 0.03) during submaximal exercise. NOS3 894T non-carriers also had a higher maximal exercise HR averaged across habitual PA groups than T allele carrier women (165 +/- 2 vs. 158 +/- 2 beats/min, p = 0.04). NOS3 894T allele carriers also tended to have a higher SV during maximal exercise than 894T non-carriers (70 +/- 2 vs. 64 +/- 2 ml/beat, p = 0.08). NOS3 T-786C genotype was not significantly associated, either independently or interactively, with any of the CV hemodynamic measures during submaximal or maximal exercise. These results suggest an association of NOS3 G894T genotype with submaximal and maximal exercise CV hemodynamic responses, especially HR, in postmenopausal women.
authors.affiliation: Department of Kinesiology, University of Maryland, College Park, MD 20742, USA.
authors.forename: B D
authors.initials: BD
authors.lastname: Hand
authors.forename: S D
authors.initials: SD
authors.lastname: McCole
authors.forename: M D
authors.initials: MD
authors.lastname: Brown
authors.forename: J J
authors.initials: JJ
authors.lastname: Park
authors.forename: R E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: A
authors.initials: A
authors.lastname: Huberty
authors.forename: L W
authors.initials: LW
authors.lastname: Douglass
authors.forename: J M
authors.initials: JM
authors.lastname: Hagberg
mesh_terms: D001794:Blood Pressure / Q000235:genetics; D002302:Cardiac Output / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010101:Oxygen Consumption / Q000235:genetics; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000502:physiology*; D013318:Stroke Volume / Q000235:genetics
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III