title: Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs.
abstract: US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrine, and atovaquone-proguanil. Because malaria parasites develop drug resistance, the US military must continue to support the creation and testing of new drugs to prevent and treat malaria until an effective malaria vaccine is developed. New antimalarial drugs also benefit civilians residing in and traveling to malarious areas.
authors.affiliation: Military Infectious Diseases Research Program, US Army Medical Research and Materiel Command, Fort Detrick, MD 21702-5012, USA. lynn.kitchen@amedd.army.mil
authors.forename: Lynn W
authors.initials: LW
authors.lastname: Kitchen
authors.forename: David W
authors.initials: DW
authors.lastname: Vaughn
authors.forename: Donald R
authors.initials: DR
authors.lastname: Skillman
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000517:prevention & control*; D008887:Military Medicine; D008889:Military Personnel; D012106:Research; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000962:Antimalarials