title: [Preparation of amylopectin modified dipyridamole liposome and its tissue distribution in mice].
abstract: OBJECTIVE
  To prepare amylopectin anchored dipyridamole (DIP) liposome and to study its tissue distribution in mice.
  
  
  METHODS
  The regular DIP liposomes were prepared by film-scatter method. The amphiphilic O-palmitoyl amylopectin was synthesized and added to modify the surface of liposome. The entrapping efficiency, zeta potential, mean diameter, span of modified and regular liposomes were assayed. The RP-HPLC was used for the determination of DIP concentration in mice tissue.
  
  
  RESULTS
  After modification, the entrapping efficiency depressed, zeta potential was raised, mean diameter and span had no obvious change. The level of DIP in lung, liver and spleen for regular liposomes were higher than that of injections. Compared with regular liposomes, the modified liposomes increased the DIP level in lung, and decreased the DIP level in liver, spleen, moreover, lengthened the retention time of DIP in lung.
  
  
  CONCLUSIONS
  The distribution of modified liposome in mice was markedly changed as compared with regular liposomes and injections. The modified liposomes had obvious lung targeting property.
authors.affiliation: Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing. chengji45@hotmail.com
authors.forename: Ji
authors.initials: J
authors.lastname: Cheng
authors.forename: Jia-bi
authors.initials: JB
authors.lastname: Zhu
authors.forename: Si-xing
authors.initials: SX
authors.lastname: Yang
authors.forename: Chang-bin
authors.initials: CB
authors.lastname: Wang
mesh_terms: D000687:Amylopectin / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D019540:Area Under Curve; D004176:Dipyridamole / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D008081:Liposomes; D008168:Lung / Q000378:metabolism*; D008297:Male; D051379:Mice; D010168:Palmitates / Q000737:chemistry*; D010316:Particle Size; D014018:Tissue Distribution
chemical_list: D008081:Liposomes; C514132:O-palmitoyl amylopectin; D010168:Palmitates; D004176:Dipyridamole; D000687:Amylopectin