[Inhibitory effect of Panax notoginseng on the VSMC proliferation induced by hyperlipidemia serum].
OBJECTIVE
To investigate the effect of P. notoginseng on vascular smooth muscle cell (VSMC) proliferation induced by hyperlipidemia serum.


METHODS
MTT method was used to investigate the effect of hyperlipidemia serum and hyperlipidemia plus P. notoginseng on VSMC proliferation.


RESULTS
Hyperlipidemia serum could promote VSMC proliferation significantly as compared with the control group (P < 0.05), while hyperlipidemia plus P. notoginseng could weaken this effect significantly (P < 0.05).


CONCLUSIONS
P. notoginseng can significantly inhibit the VSMC proliferation induced by hyperlipidemia serum.
Wang
Jing
J
Changhai Hospital, Second Military Medicine University, Shanghai 200433, China.
Hu
Jin-Hong
JH
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D053723:Panax notoginseng / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum
D004365:Drugs, Chinese Herbal