Multivalent antimicrobial peptides from a reactive polymer scaffold.
We report an application of the principle of multivalency to create new antimicrobial agents using the reactive polymaleic anhydride (PMA) chain to link antimicrobial tetrapeptides to afford multivalent variants containing approximately 40 monomer units. Relative to the free peptides, the product shows a 10-fold improvement in IC(50) without provoking more severe hemolysis of red blood cells. Thus, multivalency or polyvalency may offer a route to enhance the activity of antimicrobial peptides.
Liu
Zhigang
Z
Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.
Deshazer
Heather
H
Rice
Amanda J
AJ
Chen
Kang
K
Zhou
Chunhui
C
Kallenbach
Neville R
NR
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008299:Maleic Anhydrides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*
D000890:Anti-Infective Agents; D008299:Maleic Anhydrides; D009842:Oligopeptides; D011108:Polymers; C016683:polymaleic anhydride