Prognostic significance of immunophenotype in aggressive non-Hodgkin's lymphoma.
The purpose of the study was to evaluate prognostic value of immunophenotype in aggressive Non-Hodgkin's lymphoma. 87 patients with immunohistologically confirmed diagnosis of aggressive Non-Hodgkin's lymphoma according to the WHO classification (2001) were under observation. Patients were treated at the Department of Hematology and Transfusiology, State Medical Academy, Tbilisi, Georgia. The IPI was calculated for each case. Overall survival was calculated from the date of diagnosis to the last follow-up or death regardless of the cause. 17 patients out of 87 were diagnosed as T-cell lymphomas. Overall survival in patients with IPI greater than 2 (poor prognosis) was shorter for T-cell lymphomas (7,6 months) in comparison with B-cell lymphomas (17,3 months) (p<0,001). T-cell phenotype should be considered as an independent factor that strongly influences the survival for patients with diagnosis of aggressive non-Hodgkin's lymphomas. Besides petipherial T-cell lymphomas occurs more frequently in the elderly, with advanced stage, frequent extranodal site involvement, and often detected high level of LDH compared with B-cell lymphomas.
Tsartsidze
E
E
Department of Hematology and Transfusiology, State Medical Academy, Tbilisi, Georgia.
Betaneli
M
M
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology*