A concise synthesis of (-)-centrolobine via a diastereoselective ring rearrangement metathesis-isomerisation sequence.
A total synthesis of (-)-centrolobine (1) based on a diastereoselective ring rearrangement metathesis-double bond isomerisation sequence and a one-pot cross metathesis-hydrogenation procedure is described.
Böhrsch
Verena
V
TU Berlin - Berlin University of Technology, Institute of Chemistry, Strasse des 17. Juni 115, Sekr. C3, 10623 Berlin, Germany.
Blechert
Siegfried
S
D007536:Isomerism; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*
D011714:Pyrans; C432457:centrolobin