title: Salicylic acid protects the skin from UV damage.
abstract: Aspirin(acetyl salicylate) has long been used as an analgesic. Salicylic acid has been reported to have anti-inflammatory properties. These activities include inhibiting activity of cox-1, cox-2, and NF-kb. In addition, salicylic acid has also been shown in some systems to induce Hsp70. We have demonstrated that salicylic acid inhibits UVB-induced sunburn cell formation, as well as increase the removal of UVB induced TT dimer formation in living skin equivalents. Given these protective properties of salicylic acid, we propose the use of salicylic acid as a topical therapeutic to protect the skin from sun damage.
authors.affiliation: Estee Lauder Companies, Melville, NY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mammone
authors.forename: David
authors.initials: D
authors.lastname: Gan
authors.forename: Earl
authors.initials: E
authors.lastname: Goyarts
authors.forename: Daniel
authors.initials: D
authors.lastname: Maes
mesh_terms: D000328:Adult; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes; D007641:Keratolytic Agents / Q000494:pharmacology*; D020156:Salicylic Acid / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D013471:Sunburn / Q000517:prevention & control*; D051996:Transcription Factor RelA / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D007641:Keratolytic Agents; D051996:Transcription Factor RelA; D020156:Salicylic Acid