[The individual prognosis of the gravity and of the outcome of acute radiation disease based on immunological indexes].
The information significance of the immunological indexes for the prognosis of gravity of course and of outcome of an acute radiation disease for the people after the exposure of ionizing radiation in clinically significant doses is studied. The value of indexes of the C-reactive protein contents, of the complement contents and of the titer of haemagglutinins in serum of a blood of 147 patients damaged at Chernobyl NPP accident as a result of external radiation gamma-exposure in combination with internal irradiation from the incorporation in an organism predominantly beta-emitting radionuclides were compared to the weight of acute radiation disease and its outcome (survival or loss). Was determined, that indexes of the contents of C-reactive protein in a peripheral blood during primary reactions on the irradiation (1-2 day after irradiation) and in latent period of disease (3-9 day after irradiation), and also titer of a complement on 3-9 day after irradiation can serve a source of information for the prognosis of probable gravity of a radiation injury and its outcome at irradiation of the man in clinically significant doses.
Mal'tsev
V N
VN
Ivanov
A A
AA
Mikhaĭlov
V F
VF
Mazurik
V K
VK
D000208:Acute Disease; D002097:C-Reactive Protein / Q000276:immunology; D047852:Chernobyl Nuclear Accident; D003165:Complement System Proteins / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D006388:Hemagglutinins / Q000097:blood / Q000276:immunology; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D011832:Radiation Injuries / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality*; D012016:Reference Values; D015996:Survival Rate; D013997:Time Factors
D006388:Hemagglutinins; D003165:Complement System Proteins; D002097:C-Reactive Protein