title: Immunology. Discriminating microbe from self suffers a double toll.
authors.affiliation: John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Post Office Box 334, Canberra, ACT 0200, Australia. chris.goodnow@anu.edu.au
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Goodnow
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000235:genetics / Q000502:physiology; D001323:Autoantibodies / Q000096:biosynthesis; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D018628:Gene Dosage; D020440:Gene Duplication; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D051379:Mice; D020412:Multifactorial Inheritance; D012326:RNA Splicing; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology; D017634:Self Tolerance; D015398:Signal Transduction; D051199:Toll-Like Receptor 7 / Q000235:genetics / Q000276:immunology*; D051217:Toll-Like Receptor 9 / Q000276:immunology*; D014998:Y Chromosome / Q000235:genetics; D000071176:Signaling Lymphocytic Activation Molecule Family
chemical_list: D000950:Antigens, Ly; D001323:Autoantibodies; D016898:Interferon-alpha; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D017452:Receptors, IgG; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9; C499172:Fcgr2b protein, mouse; C477038:Tlr7 protein, mouse; C495370:Tlr9 protein, mouse; C000604063:Slamf6 protein, mouse; D000071176:Signaling Lymphocytic Activation Molecule Family