Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.
To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
Wang
Sophia S
SS
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC# 7234, Bethesda, Rockville, MD 20892-7234, USA. wangso@mail.nih.gov
Cozen
Wendy
W
Severson
Richard K
RK
Hartge
Patricia
P
Cerhan
James R
JR
Davis
Scott
S
Welch
Robert
R
Rothman
Nathaniel
N
Chanock
Stephen J
SJ
D000328:Adult; D000368:Aged; D017398:Alternative Splicing; D016022:Case-Control Studies; D019940:Genes, bcl-1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors