title: Resuscitation-promoting factors: distribution among actinobacteria, synthesis during life-cycle and biological activity.
abstract: We have identified new members of the resuscitation-promoting factor (Rpf) protein family in numerous as yet unsequenced actinobacteria suggesting that Rpfs are common in this bacterial group. Formation and final delivery of the Rpf proteins varied from strain to strain and were dependent on growth conditions. Rpfs were found to act complementary to resuscitate other actinobacteria and might therefore be useful tools for the isolation of new actinobacterial species, especially from soil samples in which lots of microorganisms may have adopted dormant states.
authors.affiliation: Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute (HKI), Beutenbergstrasse 11a, D-07745, Jena, Germany. volker.schroeckh@hki-jena.de
authors.forename: Volker
authors.initials: V
authors.lastname: Schroeckh
authors.forename: Karin
authors.initials: K
authors.lastname: Martin
mesh_terms: D039903:Actinobacteria / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D016207:Cytokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000032:analysis; D015964:Gene Expression Regulation, Bacterial; D016982:Micrococcus luteus / Q000187:drug effects / Q000254:growth & development; D008969:Molecular Sequence Data; D012240:Rhodococcus / Q000187:drug effects / Q000254:growth & development; D017422:Sequence Analysis, DNA
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines; D004269:DNA, Bacterial; C113704:resuscitation-promoting factor, bacteria