Comparative evaluation of two perfusion solutions for liver preservation and transplantation.
The University of Wisconsin solution (UW) and the Bretschneider solution (HTK) were used in 39 adult cadaveric donors: 22 perfused with UW (group 1) and 17 with HTK (group II). Donors were flushed through the aorta (UW, 5 to 6 L; HTK, 8 to 10 L) and through the portal vein (UW or HTK, 1 L). Grafts perfused with HTK showed lower levels of SGOT at postoperative day 7 than those transplanted with UW (38 +/- 19 vs 58 +/- 31, P < .05). No difference was observed in other functional and outcome parameters. No cases of primary dysfunction were observed. Six-month graft survival was 85.7% in HTK group and 80.9% in UW group (P = NS). Six unrelated deaths were observed. Five biliary complications were observed in five patients: three in the UW group and two in the HTK group. In conclusion, data fail to show major differences between the two solutions used.
Avolio
A W
AW
Transplant Unit, A. Gemelli Hospital, Catholic University of Rome, Italy. alfonso.avolio@tin.it
Agnes
S
S
Nure
E
E
Maria
G
G
Barbarino
R
R
Pepe
G
G
Castagneto
M
M
D000328:Adult; D002102:Cadaver; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D016019:Survival Analysis; D014019:Tissue Donors; D016896:Treatment Outcome
D019188:Organ Preservation Solutions