title: The diallelic locus encoding the minor histocompatibility antigen HA-1 is evolutionarily conserved.
abstract: The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1(H) allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1(H) allele is present in non-human primate species and dogs. Interestingly, both the HA-1(H) T-cell epitope and its non-immunogenic counterpart HA-1(R) are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. b.wieles@lumc.nl
authors.forename: B
authors.initials: B
authors.lastname: Wieles
authors.forename: J
authors.initials: J
authors.lastname: Pool
authors.forename: M
authors.initials: M
authors.lastname: Wilke
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kolb
authors.forename: R E
authors.initials: RE
authors.lastname: Bontrop
authors.forename: E
authors.initials: E
authors.lastname: Goulmy
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004285:Dogs; D019143:Evolution, Molecular; D006579:Heterozygote; D006720:Homozygote; D008253:Macaca mulatta / Q000235:genetics*; D015778:Minor Histocompatibility Antigens / Q000737:chemistry / Q000235:genetics*; D008912:Minor Histocompatibility Loci; D008969:Molecular Sequence Data; D009842:Oligopeptides; D002679:Pan troglodytes / Q000235:genetics*; D051381:Rats
chemical_list: C110615:HA-1 antigen; D015778:Minor Histocompatibility Antigens; D009842:Oligopeptides