Carnitine supplementation induces long-chain acylcarnitine production--studies in the VLCAD-deficient mouse.
Carnitine supplementation does not affect carnitine concentrations in tissues of wild-type and very long-chain acyl-CoA dehydrogenase-deficient mice, but results in an increase in long-chain acylcarnitine production.
Liebig
M
M
Department of General Pediatrics, University Children's Hospital, Duesseldorf, Germany.
Gyenes
M
M
Brauers
G
G
Ruiter
J P N
JP
Wendel
U
U
Mayatepek
E
E
Strauss
A W
AW
Wanders
R J A
RJ
Spiekerkoetter
U
U
D044942:Acyl-CoA Dehydrogenase, Long-Chain / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D019587:Dietary Supplements; D004195:Disease Models, Animal; D006706:Homeostasis; D008052:Lipid Metabolism, Inborn Errors / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010805:Physical Conditioning, Animal
C116917:acylcarnitine; D044942:Acyl-CoA Dehydrogenase, Long-Chain; D002331:Carnitine