Proline/pipecolinic acid-promoted copper-catalyzed P-arylation.
We have developed a convenient and efficient approach for P-arylation of organophosphorus compounds containing P-H. Using commercially available and inexpensive proline and pipecolinic acid as the ligands greatly improved the efficiency of the coupling reactions, so the method can provide an entry to arylphosphonates, arylphosphinates and arylphosphine oxides.
Huang
Cheng
C
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Tang
Xu
X
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010875:Pipecolic Acids / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D006846:Hydrocarbons, Halogenated; D007454:Iodides; D009943:Organophosphorus Compounds; D010875:Pipecolic Acids; D003300:Copper; C073870:cuprous iodide; D011392:Proline