title: [Biological investigation of thyroid cancer].
abstract: Thyroid carcinomas represent the most common endocrine malignancy, and several biological markers are proposed according to the different types of this cancer: for papillary cancer, thyroglobulin constitutes an excellent prognostic factor and rearrangements of ret oncogene can be useful in diagnosis. In sporadic medullary carcinoma, calcitonin is a diagnosis marker of choice, and coupled with ACE, can prevent relapse. Regarding familial medullary carcinoma, mutation screening in ret oncogene leads to early detection of new cases.
authors.affiliation: Service de Biologie Clinique, Institut Salah Azaiez de Tunis.
authors.forename: Hayet
authors.initials: H
authors.lastname: Douik
authors.forename: Abderraouf
authors.initials: A
authors.lastname: Ghanem
authors.forename: Aouatef
authors.initials: A
authors.lastname: Jmal
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.forename: Samia
authors.initials: S
authors.lastname: Gara
authors.forename: Monia
authors.initials: M
authors.lastname: Abdennebi
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015316:Genetic Therapy; D006801:Humans; D051096:Proto-Oncogene Proteins c-ret / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002116:Calcitonin; D013954:Thyroglobulin; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human