[Apoptosis and programmed cell death. Host parasite relationship new paradigm].
Apoptosis and programmed cell death are amongst the most fascinating new concepts for understanding the host-parasite relationship. A growing body data is raising questions about the impact of the death of an individual parasite on the survival of the parasite population as a whole. Does the parasite induce the death of the host cell as an expression of virulence or does it inhibit that death as a factor for transmissibility? Current evidence that these effects are mediated through specific highly regulated mechanisms suggest that deciphering programmed cell death could provide new tools for control of parasitic diseases.
Picot
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L'EA 37-32, Praticien, Virulence et résistance des Plasmodium, Faculté de Médecine, Université Claude Bernard, Lyon, France. picot@sante.univ-lyon1.fr
D000818:Animals; D017209:Apoptosis; D006790:Host-Parasite Interactions; D006801:Humans; D010961:Plasmodium / Q000502:physiology; D014345:Trypanosoma / Q000502:physiology