title: Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone).
abstract: A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.
authors.affiliation: Department of Bionanosystem Engineering, Chonbuk National University, Chonju 56-756, Republic of Korea.
authors.forename: P
authors.initials: P
authors.lastname: Prabu
authors.forename: N
authors.initials: N
authors.lastname: Dharmaraj
authors.forename: Santosh
authors.initials: S
authors.lastname: Aryal
authors.forename: B M
authors.initials: BM
authors.lastname: Lee
authors.forename: Vijaya
authors.initials: V
authors.lastname: Ramesh
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D003094:Collagen; D016503:Drug Delivery Systems; D011091:Polyesters
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D003094:Collagen