Effect of delta-sleep-inducing peptide on activity of enzymes of biogenic amine metabolism in the brain of Wistar and August rats.
Activity of enzymes catalyzing synthesis and degradation of serotonin and dopamine in brain structures of Wistar and August rats was measured biochemically under normal conditions and after short-term exposure to delta-sleep-inducing peptide. The effects of the test peptide manifested in activation of the serotoninergic system and inhibition of the dopaminergic system, particularly in the caudate nucleus. These changes were most pronounced in the brain of Wistar rats.
Dovedova
E L
EL
Laboratory for Ultrastructure and Cytochemistry of the Brain, Institute of Brain Research, Russian Academy of Medical Sciences, Moscow.
Khrustalev
D A
DA
Khudoerkov
R M
RM
D000818:Animals; D001679:Biogenic Amines / Q000737:chemistry*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000196:embryology; D002540:Cerebral Cortex / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013045:Species Specificity
D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D010455:Peptides; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D003701:Delta Sleep-Inducing Peptide; D004298:Dopamine