Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides.
A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.
Almasirad
Ali
A
Department of Medicinal Chemistry, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran.
Hosseini
Rohollah
R
Jalalizadeh
Hassan
H
Rahimi-Moghaddam
Zohreh
Z
Abaeian
Nazila
N
Janafrooz
Maryam
M
Abbaspour
Mohammad
M
Ziaee
Vahid
V
Dalvandi
Afshin
A
Shafiee
Abbas
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006834:Hydrazines; D062367:ortho-Aminobenzoates; C001209:fenamic acid