Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors.
We report an unusual case of osteonecrosis of the femoral head associated with recurrent myopathy and bone abnormalities in a two-year-old girl, in whom symptoms occurred after a ten-day course of oral betamethasone for infectious wheezy bronchitis, and eventually recurred and were worsened by topical treatment; a hypersensitivity to glucocorticoids is hypothesised.
Drigo
Ilenia
I
Department of Reproductive and Developmental Science and IRCCS, Istituto per I'Infanzia Burlo Garofolo, Clinica Pediatrica, Trieste, Italy.
Saccari
Alessia
A
Barbi
Egidio
E
Bartoli
Fiora
F
Decorti
Giuliana
G
Ventura
Alessandro
A
D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D001991:Bronchitis / Q000188:drug therapy; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D001623:Betamethasone