Evaluation of available IgE-binding epitope data and its utility in bioinformatics.
This paper reviews the role played by IgE-binding epitopes in eliciting clinical symptoms, the types of IgE-binding epitopes in allergenic proteins, the methods used to identify IgE-binding epitopes, and the availability of IgE-binding epitopes in allergenic sources. Finally, bioinformatics methods to assess protein allergenicity using knowledge of IgE-binding epitopes are discussed.
Bannon
Gary A
GA
Monsanto Company, St. Louis, Missouri, USA. gary.a.bannon@monsanto.com
Ogawa
Tadashi
T
D000485:Allergens / Q000737:chemistry / Q000276:immunology*; D000595:Amino Acid Sequence; D019295:Computational Biology; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*; D005512:Food Hypersensitivity; D007073:Immunoglobulin E / Q000378:metabolism*; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000276:immunology; D017385:Sequence Homology
D000485:Allergens; D000939:Epitopes; D011506:Proteins; D007073:Immunoglobulin E