title: Chronic granulomatous disease with unusual clinical manifestation, outcome, and pattern of inheritance in an Iranian family.
abstract: CGD is a rare phagocytic disorder manifesting as recurrent, severe bacterial and fungal infections. We describe an Iranian family with eight children, of whom six, five males and one female were diagnosed with CGD resulting in diffuse pulmonary sterile granulomatous lesions. Three died despite multiple courses of antibiotic and antituberculosis medications while three are alive, to date they are asymptomatic but with imaging and pathologic findings of pulmonary granulomatosis, treated with steroids. The parents are healthy. Our report describes the clinical manifestations and outcome in this family. The inheritance pattern suggests an autosomal recessive pattern with high penetrance.
authors.affiliation: National Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed F
authors.initials: SF
authors.lastname: Tafti
authors.forename: Payam
authors.initials: P
authors.lastname: Tabarsi
authors.forename: Nahal
authors.initials: N
authors.lastname: Mansouri
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mirsaeidi
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Motazedi Ghajar
authors.forename: Shirin
authors.initials: S
authors.lastname: Karimi
authors.forename: Hossain M
authors.initials: HM
authors.lastname: Najar
authors.forename: Davood
authors.initials: D
authors.lastname: Mansouri
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree