[Protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury in rats].
OBJECTIVE
To research the protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury.


METHODS
Using the middle cerebral artery occlusion model (MCAO) in rats, we investigated the influence of pueraria flavonoid on the brain water content, the infarct volume, the activities of SOD, and the content of MDA.


RESULTS
Pueraria Flavonoid could obviously reduce the brain water content and the infract volume in MCAO, increase the activities of SOD, and decrease the content of MDA in the cerebral ischemia- reinfusion model of rats.


CONCLUSIONS
Pueraria has the function of scavenging free radicals and the protective effect on ischemic brain tissue.
Wang
Pei-Yuan
PY
Department of Neurobiology, Anhui Medical University, Hefei 230032, China.
Wang
Hai-Ping
HP
Li
Guang-Wu
GW
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
D005419:Flavonoids; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase