Role of stem cells in adaptation to hypoxia and mechanisms of neuroprotective effect of granulocytic colony-stimulating factor.
The role of regional cerebral neural precursor cells in restoration of the CNS activity during the development of hypoxic encephalopathy and the participation of the bone marrow mesenchymal stem cells in the formation of blood system reactions in hypoxia are shown. The mechanisms of neuroprotective effect of granulocytic colony-stimulating factor in severe oxygen insufficiency are studied. The specific psychopharmacological effect of granulocytic colony-stimulating factor is due to mobilization and determined homing of the bone marrow mesenchymal stem cells in damaged CNS zones with subsequent differentiation of these cells into specialized elements and due to activation of erythropoiesis.
Zyuz'kov
G N
GN
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Suslov
N I
NI
Dygai
A M
AM
Zhdanov
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002490:Central Nervous System / Q000378:metabolism; D015672:Erythroid Precursor Cells / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism* / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D000860:Hypoxia; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009474:Neurons / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology*; D013997:Time Factors
D018696:Neuroprotective Agents; D016179:Granulocyte Colony-Stimulating Factor; D010100:Oxygen