HIV pathogenesis: Nef loses control.
In this issue of Cell, Schindler et al. (2006) show that the Nef protein from nonpathogenic strains of simian immunodeficiency virus (SIV) induces the downregulation of host T cell receptor/CD3, whereas Nef from human immunodeficiency virus (HIV-1) does not. This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus.
Foster
John L
JL
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA.
Garcia
J Victor
JV
D000818:Animals; D015536:Down-Regulation; D015693:Gene Products, nef / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D017958:Lentiviruses, Primate / Q000276:immunology / Q000502:physiology*; D008213:Lymphocyte Activation; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D054311:nef Gene Products, Human Immunodeficiency Virus
D015693:Gene Products, nef; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D054311:nef Gene Products, Human Immunodeficiency Virus