Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome.
POEMS is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. It is a poorly understood paraneoplastic syndrome that stems from an underlying plasma cell dyscrasia. Of the skin changes, the glomeruloid hemangioma is considered to be a specific marker of POEMS syndrome. We describe a 68-year-old man who presented to his dermatologist with multiple hemangiomas, whose biopsy diagnosis of glomeruloid hemangioma resulted in further evaluation and an eventual diagnosis of POEMS.
Phillips
Julie A
JA
Division of Dermatology, University of Louisville, KY 40202, USA.
Dixon
Julie E
JE
Richardson
Jeffrey B
JB
Fabre
Vilma C
VC
Callen
Jeffrey P
JP
D000368:Aged; D006391:Hemangioma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000150:complications / Q000175:diagnosis*; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology