Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium.
It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+]i) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F2alpha (PGF2alpha). PGF2alpha increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction.
Woodcock
Nicola A
NA
Department of Biological Sciences, University of Warwick, Coventry, UK.
Taylor
Colin W
CW
Thornton
Steven
S
D002118:Calcium / Q000378:metabolism*; D003285:Contractile Proteins / Q000378:metabolism*; D015237:Dinoprost / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism*; D009994:Osmolar Concentration; D010120:Oxytocics / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D003285:Contractile Proteins; D010120:Oxytocics; D010121:Oxytocin; D015237:Dinoprost; D002118:Calcium