Adjusting neurophysiological computations in the adult olfactory bulb.
The olfactory bulb receives signals from olfactory sensory neurons and conveys them to higher centers. The mapping of the sensory inputs generates a reproducible spatial pattern in the glomerular layer of the olfactory bulb for each odorant. Then, this restricted activation is transformed into highly distributed patterns by lateral interactions between relay neurons and local interneurons. Thus, odor information processing requires the spatial patterning of both sensory inputs and synaptic interactions. In other words, odor representation is highly dynamic and temporally orchestrated. Here, we describe how the local inhibitory network shapes the global oscillations and the precise synchronization of relay neurons. We discuss how local inhibitory interneurons transpose the spatial dimension into temporal patterning. Remarkably, this transposition is not fixed but highly flexible to continuously optimize olfactory information processing.
Lledo
Pierre-Marie
PM
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. pmlledo@pasteur.fr
Lagier
Samuel
S
D000818:Animals; D001683:Biological Clocks; D001931:Brain Mapping; D004594:Electrophysiology; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*