title: Childhood visceral leishmaniasis.
abstract: Visceral leishmaniasis (VL) is caused by the protozoan parasite Leishmania donovani and transmitted by the bite of infected sandfly Phlebotomus argentipes. Nearly half of the VL cases occur in children (childhood or paediatric VL). The clinical manifestations of childhood VL are more or less same as in the adults. Prolonged fever with anorexia and loss of appetite are the major presenting features. Marked enlargement of the spleen and liver (spleen larger than liver) with moderate to severe anaemia and changes in hair take place. Bacterial infection is a common coinfection and intestinal parasitic infestations are very common in children with VL. Liver function tests, blood, urine and stool may show abnormalities. Confirmation of diagnosis is made by demonstration of parasite by microscopic examination and culture of materials obtained by bone marrow aspiration or splenic puncture. Sodium antimony gluconate (stibogluconate) has been the drug of choice for over past 50 yr. Pentamidine isothionate, though effective is relatively toxic. Amphotericin B is the most effective drug for the treatment of VL. Miltefosine is the first-ever oral drug, is highly effective. Post kala-azar dermal leishmaniasis (PKDL) in children poses a therapeutic challenge. In the absence of an ideal vaccine for VL, control measures would essentially include prevention of transmission through vector control and community awareness.
authors.affiliation: Rajendra Memorial Research Institute of Medical Sciences,(ICMR), Patna , India. sujitkbhattacharya@yahoo.com
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: Dipika
authors.initials: D
authors.lastname: Sur
authors.forename: Juntra
authors.initials: J
authors.lastname: Karbwang
mesh_terms: D000284:Administration, Oral; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology; D006801:Humans; D007893:Leishmania donovani / Q000378:metabolism; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology; D011576:Psychodidae / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D000666:Amphotericin B; D000967:Antimony Sodium Gluconate