Enantioselective total synthesis of (+)-SCH 351448.
[structure: see text] A stereoselective synthesis of SCH 351448 has been completed. Twelve of the fourteen stereogenic centers were established through chiral enolate reactions, and six key C-C bonds were formed by metathesis reactions.
Crimmins
Michael T
MT
Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, 27599, USA. crimmins@email.unc.edu
Vanier
Grace S
GS
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008847:Micromonospora / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D007783:Lactones; C451479:SCH 351448