title: A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly.
abstract: A flow process for the multi-step synthesis of the alkaloid natural product (+/-)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Jon
authors.initials: J
authors.lastname: Deeley
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Griffiths-Jones
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Steen
authors.initials: S
authors.lastname: Saaby
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Tranmer
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D047151:Amaryllidaceae Alkaloids; D001688:Biological Products; C424626:oxomaritidine