title: Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents.
abstract: On the basis of potent anti-HCV activity of 2'-C-methyladenosine, novel 2'-C-hydroxymethyladenosine analogues 2a-c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2'-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Byul Nae
authors.initials: BN
authors.lastname: Yoo
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Su Kyung
authors.initials: SK
authors.lastname: Seol
authors.forename: Sung Key
authors.initials: SK
authors.lastname: Jang
authors.forename: Kang Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry; D015195:Drug Design; D016174:Hepacivirus / Q000378:metabolism*; D006526:Hepatitis C / Q000188:drug therapy*; D008956:Models, Chemical; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000627:therapeutic use; D012367:RNA, Viral / Q000737:chemistry; D012263:Ribonucleosides / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D012367:RNA, Viral; D012263:Ribonucleosides; D012321:DNA-Directed RNA Polymerases