title: Lymphocele after renal transplantation: the influence of the immunosuppressive therapy.
abstract: Lymphocele is a complication of renal transplantation, representing a lymphatic collection around the grafted kidney. The use of the immunosuppressive agent sirolimus (SRL) has been associated with a significant increase in lymphocele formation. This complication has been related to the antiproliferative activity of SRL, which delays surgical wound repair and closure of injured lymphatic vessels. The aim of this study was to relate the incidence of lymphocele with immunosuppression among 158 renal transplant patients operated with routine closure of all the visible lymphatic vessels around the iliac vessels and at the renal hilum. The incidence of lymphocele was not significantly different among the various immunosuppressive regimens.
authors.affiliation: Department of Surgery, Organ Transplantation, Catholic University, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Tondolo
authors.forename: F
authors.initials: F
authors.lastname: Citterio
authors.forename: A
authors.initials: A
authors.lastname: Massa
authors.forename: M P
authors.initials: MP
authors.lastname: Salerno
authors.forename: J
authors.initials: J
authors.lastname: Romagnoli
authors.forename: G
authors.initials: G
authors.lastname: Nanni
authors.forename: M
authors.initials: M
authors.lastname: Castagneto
mesh_terms: D004322:Drainage; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008210:Lymphocele / Q000453:epidemiology / Q000209:etiology*; D011183:Postoperative Complications / Q000453:epidemiology; D017582:Renal Replacement Therapy; D020123:Sirolimus / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus