Onset of severe refractory thrombocytopenia following surgery in a patient with type 2B von Willebrand disease--a case report.
A case of a severe thrombocytopenia occurring in a patient with type 2B von Willebrand disease following an esophagectomy is described. As platelet transfusions were ineffective due to alloimunization, effective hemostasis was achieved only with the factor VIII/von Willebrand factor concentrate Haemate P.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione-Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. massimo.franchini@mail.azosp.vr.it
D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000601:surgery; D004938:Esophageal Neoplasms / Q000150:complications / Q000601:surgery; D005169:Factor VIII / Q000008:administration & dosage; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology; D013921:Thrombocytopenia / Q000188:drug therapy / Q000276:immunology*; D014842:von Willebrand Diseases / Q000150:complications* / Q000188:drug therapy
D006680:HLA Antigens; D007518:Isoantibodies; D005169:Factor VIII