[Analysis of the Moscow population of Neisseria meningitidis strains by the method of multilocus sequencing-typing].
The analysis of meningococcal strains of different serogroups, isolated from the liquor of patients in Moscow, which was carried out with the method of multilocus sequencing-typing (MLST), was presented. At the periods of epidemic morbidity rises in Moscow the prevalence of group A meningococcal strains, belonging to subgroups III with sequence-types 5 (in the 1970s) and 7 (in 1996), was noted, and at a period between epidemics strains of genetic subgroups VI and X were isolated. Meningococcal strains, groups B and C, isolated in 1995 - 2002, had, as a rule, unique sequence-types, differing both one from another and from N. meningitidis sequence-types detected in other countries. Among group B meningococci the prevalence of strains belonging to clonal complex ST-18 was noted, while for group C meningococcci strains belonging to clonal complex ST-41/44 were most typical. Such genetic variability of circulating meningococci was regarded as characteristic of the period between epidemics, observed in Moscow since the end of the 1980s.
Mironov
K O
KO
Platonov
A E
AE
Koroleva
I S
IS
Shipulin
G A
GA
D002555:Cerebrospinal Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D008589:Meningococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D017720:Molecular Epidemiology; D009031:Moscow / Q000453:epidemiology; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012703:Serotyping; D013045:Species Specificity
D004269:DNA, Bacterial