Quinolizidine alkaloids with anti-HBV activity from Sophora tonkinensis.
A new matrine-type alkaloid, (-)-14 beta-hydroxyoxymatrine (1), was isolated from the roots and rhizomes of Sophora tonkinensis Gapnep. (Leguminosae), together with five known matrine-type alkaloids, (-)-14 beta-hydroxymatrine (2), (+)-oxymatrine (3), (+)-matrine (4), (+)-sophoranol (5), and (-)-5 alpha-hydroxysophocarpine ( 6), as well as with two known cytisine-type alkaloids, (-)-cytisine (7) and (-)- N-methylcytisine (8). Their structures were elucidated by spectroscopic methods. Compounds 1, 5 and 7 showed potent anti-HBV activity with an inhibitory potency against HBsAg secretion of 22.6 %, 31.1 % and 33.2 %, and against HBeAg secretion of 30.4 %, 26.3 % and 27.8 %, respectively.
Ding
Pei-Lan
PL
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China.
Huang
Hai
H
Zhou
Pei
P
Chen
Dao-Feng
DF
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D011807:Quinolizines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029909:Sophora / Q000737:chemistry*
C514908:14-hydroxyoxymatrine; D000470:Alkaloids; D000998:Antiviral Agents; D011807:Quinolizines