Analysis of the reactions used for the preparation of drug candidate molecules.
The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.
Carey
John S
JS
GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Tonbridge, UK. john.s.carey@gsk.com
Laffan
David
D
Thomson
Colin
C
Williams
Mike T
MT
D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004345:Drug Industry / Q000706:statistics & numerical data; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
D004364:Pharmaceutical Preparations