title: Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.
abstract: The nucleoside 5-formyl-2'-deoxyuridine has been used as a starting point for the generation of novel 5-substituted pyrimidine nucleosides that are shown to possess significant antiviral activity against two representative orthopoxviruses, namely vaccinia virus and cowpox virus.
authors.affiliation: Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Longhu
authors.initials: L
authors.lastname: Zhou
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Keith
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
authors.forename: Paul F
authors.initials: PF
authors.lastname: Torrence
mesh_terms: D000818:Animals; D001694:Biological Warfare / Q000517:prevention & control*; D015608:Cowpox virus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012899:Smallpox / Q000517:prevention & control*; D014616:Vaccinia virus / Q000187:drug effects*
chemical_list: D011741:Pyrimidine Nucleosides