[Metabolic abnormalities, lipodystrophy and cardiovascular risk in HIV-infected patients].
Life expectancy of HIV-infected patients has improved considerably with HAART. However long term use of HAART is linked with lipodystrophy syndrom (subcutaneous lipoatrophy and central fat accumulation) associated with dyslipemia (hypoHDL, hyperLDL and hypertriglyceridemia) and insulin resistance. It is also linked with mitochondrial toxicity clinically expressed by chronic fatigue syndrom and premature aging. The induced metabolic syndrom has cardiovascular consequences and myocardial infarction is the cause of 7% of the HIV-infected deaths in 2000. Assessment of these complications should be done at least every year. Treatment options concern antiretroviral therapy with the search for the least toxic drug (but with equal antiviral efficacy), symptomatic treatment (statin, fibrates, thiazolidinediones, metformin) and lifestyle modifications (first of all, stopping cigarette smoking!)
Leclercq
Pascale
P
Centre d'information et de soins de l'immunodeficience humaine, hôpital Albert-Michallon, 38043 Grenoble Cedex 09. PLeclercq@chu-grenoble.fr
Blanc
Myriam
M
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D050171:Dyslipidemias / Q000209:etiology* / Q000517:prevention & control; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D012307:Risk Factors