[Effects of different immunodepressants on the sperm parameters of kidney transplant recipients].
OBJECTIVE
To study the effects of different immunodepressants on the sperm parameters of kidney transplant recipients.


METHODS
In 15 healthy fertile men and 37 kidney transplant recipients, ejaculates were aseptically obtained by masturbation. Thirty-seven patients were divided into two groups, 20 patients were treated with Prograf (FK506) combination with mycophenolate mofetil (MMF) and prednisone; 17 patients were treated with cyclosporine (CsA) combination with azathioprine with prednisone. The sperm viability, mobility parameters such as prorsad percentage motility, straight line velocity (VSL), curve line velocity (VCL), velocity of average path (VAP) and morph were estimated with a computer-assisted sperm analyzer (CASA) provided with a multiple-exposure photography system.


RESULTS
There were no significant difference in sperm viability rate [(81.7 +/- 5.7)%, (79.4 +/- 6.8)% and (83.8 +/- 6.0)%], VCL [(24.1 +/- 8.6)%, (23.9 +/- 4.4)%, (24.8 +/- 4.2)% ] and VAP [(19.7 +/- 6.6)%, (18.6 +/- 2.9)%, (21.0 +/- 4.0)%] among groups of FK506, CsA and control, respectively (P > 0.05). The rate of anomaly [(67.8 +/- 5.7)%], the prorsad percentage motility [(46.4 +/- 8.1)%] and VSL [(15.4 +/- 4.6)%] in the group of FK506 were respectively significantly lower and higher than those in the group of CsA [(80.1 +/- 5.6%, (33.3 +/- 6.4)%, (10.2 +/- 2.4)%] (P < 0.05).


CONCLUSIONS
The application of FK506 combined with MMF could help recover the mobility and morphology of the sperm in kidney transplantation recipients.
Cao
Zheng-Guo
ZG
Department of Urology, Anhui Provincial Hospital, Hefei Anhui 230001, China. zgcao2002@126.com
Liu
Ji-Hong
JH
Zhu
Yu-Ping
YP
Zhou
Si-Wei
SW
Qi
Ling
L
Dong
Xiao-Cheng
XC
Wu
Bin
B
Lin
Zheng-Bin
ZB
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016572:Cyclosporine / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*; D016559:Tacrolimus / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid; D011241:Prednisone; D016559:Tacrolimus