Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa.
Polyvinylpyrrolidone (PVP), a polymer of the monomer N-vinylpyrrolidone with various molecular weights, was originally developed as a plasma expander. Currently, it is widely used in hair sprays, skin care products, fruit juices, and as a retarding agent in drugs such as procaine and hormones. PVP polymers with a molecular weight greater than 20,000 cannot be excreted by the kidneys and therefore are phagocytosed and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease. We report a case of localized cutaneous PVP storage disease presenting with persistent upper lip swelling and mimicking cheilitis granulomatosa, which has never been reported before.
Chi
Ching-Chi
CC
Department of Dermatology, Chang Gung Memorial Hospital-Chiayi, Chiayi, Taiwan.
Wang
Shu-Hui
SH
Kuo
Tseng-tong
TT
D002613:Cheilitis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D006644:Histiocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects*; D010592:Pharmaceutic Aids / Q000009:adverse effects* / Q000378:metabolism; D011205:Povidone / Q000009:adverse effects* / Q000378:metabolism; D012871:Skin Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D010592:Pharmaceutic Aids; D011205:Povidone