title: Current status of dosing and quantification of acute renal replacement therapy. Part 1: mechanisms and consequences of therapy under-delivery.
abstract: The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically-ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance-related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examines the factors affecting delivery of prescribed acute renal replacement therapy dose. The review continues in Part 2 and examines the implications of recent advances in this area for clinical practice.
authors.affiliation: Middlemore Hospital, Auckland, New Zealand. mrmarsh@woosh.co.nz
authors.forename: Mark R
authors.initials: MR
authors.lastname: Marshall
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers; D016638:Critical Illness; D006801:Humans; D017582:Renal Replacement Therapy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers