A novel approach to chronic total occlusions: the crosser system.
OBJECTIVE
To evaluate safety and efficacy of the CROSSER CTO Recanalization System (CROSSER).


BACKGROUND
The CROSSER, a novel device dedicated to recanalization of chronic total occlusions (CTO), relies on a monorail catheter delivering vibrational energy to facilitate the crossing of occluded coronary arteries.


METHODS
We included de novo or restenotic occlusions in native coronary arteries with typically unfavorable characteristics and a prior failed guidewire attempt either performed in a previous procedure or just before the usage of the CROSSER. The end points analyzed were technical success (ability to cross or facilitate a guidewire crossing into the true lumen), angiographic success (<20% residual stenosis and TIMI flow grade 3), and clinical success (angiographic success and freedom from major adverse cardiac events at 30 days).


RESULTS
Twenty-eight patients (30 lesions) were included. The morphology was blunt in 83.3% and the length of the occlusion was >20 mm in 76.6%. The median age of the CTO was 9 months (range 3-60 months). Technical success was obtained in 19 (63%) occlusions and angiographic success in 16 (53%): 26.3% in lesions with prior procedural failure and 73.7% when CROSSER was attempted after initial guidewire failure. Complications were: one guidewire perforation without consequences and one peri-procedural myocardial infarction (MI). No events occurred within 30-day follow-up after discharge.


CONCLUSIONS
In our experience, the CROSSER System is safe and increases the success of opening CTO refractory to guidewires. This novel device may represent an useful adjunct to the armamentarium of the interventional cardiologist.
Melzi
Gloria
G
EMO Centro Cuore Columbus, Milan, Italy.
Cosgrave
John
J
Biondi-Zoccai
Giuseppe L
GL
Airoldi
Flavio
F
Michev
Iassen
I
Chieffo
Alaide
A
Sangiorgi
Giuseppe M
GM
Montorfano
Matteo
M
Carlino
Mauro
M
Colombo
Antonio
A
D000368:Aged; D006328:Cardiac Catheterization / Q000295:instrumentation*; D002908:Chronic Disease; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use*