title: Urea hydrogen peroxide determination in whole blood using europium tetracycline probe.
abstract: We introduce the use of a lanthanide complex, tetracycline-europium, for the clinical diagnosis of urea hydrogen peroxide in human whole blood. The values obtained agree with the urea concentration variation verified in 49 patients, including 12 predialysis, 12 peritoneal, and 15 dialysis subjects, and 10 controls. This method is noninvasive and can help in the identification of renal and cardiac diseases.
authors.affiliation: FATEC-SP/CEETEPS, São Paulo, SP, Brazil. lcourrol@fatecsp.br
authors.forename: Lilia C
authors.initials: LC
authors.lastname: Courrol
authors.forename: Maria H
authors.initials: MH
authors.lastname: Bellini
authors.forename: Luiz V G
authors.initials: LV
authors.lastname: Tarelho
authors.forename: Flávia R O
authors.initials: FR
authors.lastname: Silva
authors.forename: Ronaldo D
authors.initials: RD
authors.lastname: Mansano
authors.forename: Laércio
authors.initials: L
authors.lastname: Gomes
authors.forename: Nilson D
authors.initials: ND
authors.lastname: Vieira
authors.forename: Nestor
authors.initials: N
authors.lastname: Shor
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D000077463:Carbamide Peroxide; D004338:Drug Combinations; D005453:Fluorescence; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D015335:Molecular Probes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010545:Peroxides / Q000097:blood*; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013754:Tetracyclines / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D004338:Drug Combinations; D015335:Molecular Probes; D009942:Organometallic Compounds; D010545:Peroxides; D013754:Tetracyclines; C488317:europium(III) tetracycline; D000077463:Carbamide Peroxide; D014508:Urea