Development of diffuse large B cell lymphoma during the maintenance therapy for B-lineage acute lymphoblastic leukemia.
Non-Hodgkin lymphoma (NHL) is a very rare complication of acute lymphoblastic leukemia (ALL). A Japanese boy presented with B-lineage ALL at the age of 2.5. He was treated with chemotherapy for standard-risk ALL. While he was receiving maintenance treatment 2 years and 9 months after the diagnosis of ALL, diffuse large B cell lymphoma (DLBL) was diagnosed from a biopsy of an abdominal mass. DLBL was treated by surgical resection followed by chemotherapy for 6 months. The patient has been free from the recurrence of ALL or DLBL for 16 months after the development of DLBL.
Kato
Itaru
I
Department of Pediatrics, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan.
Manabe
Atsushi
A
Aoyama
Chiaki
C
Kamiya
Takahiro
T
Morimoto
Tsuyoshi
T
Matsufuji
Hiroshi
H
Suzuki
Koyu
K
Kitagawa
Yoshiro
Y
Hori
Toshinori
T
Tsurusawa
Masahito
M
Kiyokawa
Nobutaka
N
Junichiro
Fujimoto
F
Hosoya
Ryota
R
D002675:Child, Preschool; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000628:therapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*