[Structural organization of macrophages in forming human placenta].
Placental macrophages (Kashchenko-Hofbauer cells) belong to a special population of tissue macrophages of human fetal provisional organs. The aim of the present study was to investigate the structure of Kashchenko-Hofbauer cells at the stage of placenta formation using the methods of light and electron microscopy and immunocytochemistry. Cytological and cytochemical peculiarities of Kashchenko-Hofbauer cells revealed in this study, leave no doubt that they belong to the tissue macrophages group. Their cytoplasm is strongly reactive with antibodies against CD68 lysosomal antigen suggesting potentially high phagocytic activity of these cells. Weak nuclear labeling with proliferation marker PCNA was found in placental macrophages.
Korzhevskiĭ
D E
DE
Otellin
V A
VA
Neokesariĭskiĭ
A A
AA
Pavlova
N G
NG
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008247:Lysosomes / Q000737:chemistry; D008264:Macrophages / Q000737:chemistry / Q000276:immunology / Q000648:ultrastructure*; D010587:Phagocytosis; D010920:Placenta / Q000276:immunology* / Q000648:ultrastructure*; D010929:Placentation; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D018809:Proliferating Cell Nuclear Antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule