title: Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa.
abstract: Polyvinylpyrrolidone (PVP), a polymer of the monomer N-vinylpyrrolidone with various molecular weights, was originally developed as a plasma expander. Currently, it is widely used in hair sprays, skin care products, fruit juices, and as a retarding agent in drugs such as procaine and hormones. PVP polymers with a molecular weight greater than 20,000 cannot be excreted by the kidneys and therefore are phagocytosed and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease. We report a case of localized cutaneous PVP storage disease presenting with persistent upper lip swelling and mimicking cheilitis granulomatosa, which has never been reported before.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital-Chiayi, Chiayi, Taiwan.
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Chi
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Wang
authors.forename: Tseng-tong
authors.initials: TT
authors.lastname: Kuo
mesh_terms: D002613:Cheilitis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D006644:Histiocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects*; D010592:Pharmaceutic Aids / Q000009:adverse effects* / Q000378:metabolism; D011205:Povidone / Q000009:adverse effects* / Q000378:metabolism; D012871:Skin Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
chemical_list: D010592:Pharmaceutic Aids; D011205:Povidone