title: Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report.
abstract: The prognosis of stage IV malignant rhabdoid tumor of the kidney (MRTK) has been extremely poor. However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. We describe a 21-month-old girl with stage IV MRTK who was successfully treated with ICE, VDCy, and radiotherapy. She remained well, without recurrence, 24 months after diagnosis. Alternating therapy with ICE and VDCy might become a standard regimen for stage IV MRTK, although further study is required to confirm its effectiveness.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan. ymasaki@sapmed.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Mizue
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hori
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuroiwa
authors.forename: Masato
authors.initials: M
authors.lastname: Hareyama
authors.forename: Takanori
authors.initials: T
authors.lastname: Oda
authors.forename: Tooru
authors.initials: T
authors.lastname: Kudoh
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nui
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuno
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirama
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dome
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D012074:Remission Induction / Q000379:methods; D018335:Rhabdoid Tumor / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide