title: An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma.
abstract: The accepted method of modelling and predicting failure/survival, Cox's proportional hazards model, is theoretically inferior to neural network derived models for analysing highly complex systems with large datasets. A blinded comparison of the neural network versus the Cox's model in predicting survival utilising data from 873 treated patients with laryngeal cancer. These were divided randomly and equally into a training set and a study set and Cox's and neural network models applied in turn. Data were then divided into seven sets of binary covariates and the analysis repeated. Overall survival was not significantly different on Kaplan-Meier plot, or with either test model. Although the network produced qualitatively similar results to Cox's model it was significantly more sensitive to differences in survival curves for age and N stage. We propose that neural networks are capable of prediction in systems involving complex interactions between variables and non-linearity.
authors.affiliation: Head and Neck Oncology Group, Faculty of Medicine, University of Liverpool, Liverpool, UK. profasjones@beestoncastle.fsnet.co.uk
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Jones
authors.forename: Azzam G F
authors.initials: AG
authors.lastname: Taktak
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Helliwell
authors.forename: John E
authors.initials: JE
authors.lastname: Fenton
authors.forename: Martin A
authors.initials: MA
authors.lastname: Birchall
authors.forename: David J
authors.initials: DJ
authors.lastname: Husband
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Fisher
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality*; D015233:Models, Statistical; D016571:Neural Networks, Computer; D017711:Nonlinear Dynamics; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016019:Survival Analysis