title: [Correlation of multislice spiral CT findings with vascular endothelial growth factor expressions and microvessel density in renal cell carcinoma].
abstract: OBJECTIVE
  To study the correlation of multislice spiral CT features and vascular endothelial growth factor (VEGF) expressions and microvessel density (MVD) in renal cell carcinoma (RCC).
  
  
  METHODS
  Fourth-seven patients with pathologically confirmed RCC were examined by multislice spiral CT, and VEGF expressions and MVD of the RCC and the adjacent normal tissues were determined by immunohistochemistry with specific monoclonal antibodies.
  
  
  RESULTS
  VEGF expression and MVD in the RCC and adjacent normal tissues increased with the pathological grades of RCC (P<0.05), VEGF expression was found to significantly correlate with MVD (r=0.67, P<0.01). The positive expression of VEGF and MVD were associated with the findings by multislice spiral CT scan of tumor size, intratumor necrosis, cystic degeneration, intensity signal, lymph node metastases, invasion of the renal vein or inferior vena cava, and invasion of the adjacent organs or distant metastases (P<0.01).
  
  
  CONCLUSIONS
  Multislice spiral CT findings can be indicative of the histopathology of RCC, and some CT findings are closely correlated with MVD and VEGF expressions in RCC, which may help evaluate the biological behavior and malignancy of the tumor and predict tumor invasion and metastasis.
authors.affiliation: Department of Radiology, Second People's Hospital of Shenzhen, Shenzhen 518035, China. xiajun2003sz@yahoo.com.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Lei
authors.forename: Pin-ni
authors.initials: PN
authors.lastname: Liu
authors.forename: Hua-jian
authors.initials: HJ
authors.lastname: Xu
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D036542:Tomography, Spiral Computed / Q000379:methods*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
chemical_list: D042461:Vascular Endothelial Growth Factor A