title: Analysis of the effect of surgical lung biopsy on serum KL-6 Levels in patients with interstitial pneumonia: surgical lung biopsy does not elevate serum KL-6 levels.
abstract: OBJECTIVE
  It is well known that the serum level of KL-6 can be an indicator of disease activity in patients with interstitial pneumonia (IP). However, surgical lung biopsy is often required for the diagnosis of IP, although this can result in IP exacerbation.
  
  
  METHODS
  The effect of surgical lung biopsy on the serum level of KL-6 in patients with IP was analyzed. Thirty-two cases of IP were examined in this study. There were no cases showing exacerbation of IP.
  
  
  RESULTS
  The serum level of KL-6 demonstrated 1067+/-550 U/ml (mean+/-SD) before lung biopsy, 991+/-471 U/ml a day, 824+/-377 U/ml 4 days and 826+/-384 U/ml 7 days after lung biopsy. The serum KL-6 levels on the 1st, 4th, 7th day after the lung biopsy were significantly lower than that before the lung biopsy (P<0.05, P<0.01 and P<0.01, respectively). The percent decrease of the serum KL-6 levels on the 4th day (the lowest level) was dependent on the urine volume, and the analysis of the urinary levels of KL-6 showed a transient increase in urinary KL-6 excretion, suggesting that the decrease in serum KL-6 levels associated with surgical lung biopsy may be caused by this increase in urinary KL-6 excretion.
  
  
  CONCLUSIONS
  Surgical lung biopsy of patients with IP has little effect on the increase in serum KL-6 levels. An elevation of serum KL-6 after surgical lung biopsy may indicate exacerbation of IP.
authors.affiliation: Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Narita
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsuchida
authors.forename: Masaki
authors.initials: M
authors.lastname: Terada
authors.forename: Toshinori
authors.initials: T
authors.lastname: Takada
authors.forename: Takehisa
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Aoki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsukada
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Hayashi
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
authors.forename: Eiichi
authors.initials: E
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood* / Q000652:urine; D001706:Biopsy / Q000009:adverse effects*; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000097:blood* / Q000652:urine; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D000951:Antigens, Neoplasm; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D007770:L-Lactate Dehydrogenase