Nickel-catalyzed indium(I)-mediated double addition of aldehydes to 1,3-dienes.
In the presence of InI, Ni(acac)2 and PPh3, several 1,3-dienes were reacted with two molecules of aldehyde to give the corresponding 1,4- and 1,6-diols. The regioselectivity of the 1,4-/1,6-diol was efficiently regulated by the addition of water; the 1,6-diol was obtained selectively in dry THF, whereas the 1,4-diol was obtained predominantly in DMI containing a small amount of water.
Hirashita
Tsunehisa
T
Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa, Nagoya, 466-8555, Japan. hirasita@nitech.ac.jp
Kambe
Shinya
S
Tsuji
Hiromitsu
H
Araki
Shuki
S