title: Surgical treatment of prosthetic valve thrombosis: ten years' experience.
abstract: OBJECTIVE
  Prosthetic valve thrombosis (PVT) is a rare, but serious, complication of heart valve replacement with a mechanical substitute. Herein is presented the authors' surgical experience of 18 patients with PVT.
  
  
  METHODS
  A total of 1,584 heart valve operations was performed in 1,365 patients at the authors' institution between June 1995 and September 2005. Surgical reports of prosthetic valve reoperations over the same period were screened. Preoperative, operative and postoperative data were collected from the patient cohorts.
  
  
  RESULTS
  Since July 1997, 18 patients (12 females, six males; mean age 35.9 +/- 11.3 years; range: 22-60 years) presented with PVT. The subtherapeutic anticoagulation level was the major etiologic factor involved in the pathogenesis of PVT. Thrombosis occurred in the mitral position in 14 patients (78%), and in the aortic position in four (22%). All mechanical valves implanted were bileaflet (1,097 St. Jude Medical, 324 CarboMedics, and 163 Sorin). The mean duration from valve replacement to PVT was 48.3 +/- 15.4 months. The majority of patients presented with poor functional status (56% in NYHA class IV) and poor anticoagulation (INR < or = 2 in 72% of cases). Valve re-replacement was performed for all patients. The 30-day mortality was 16.7%.
  
  
  CONCLUSIONS
  PVT is a potentially fatal complication of heart valve replacement. These acceptable results suggest that early surgical intervention might be a safe and effective treatment of choice in patients with PVT. Patients with mechanical valve prostheses should be informed adequately about the need for, and the importance of, an effective anticoagulation regimen.
authors.affiliation: Atatürk Education and Research Hospital, Department of Cardiovascular Surgery. blafci@hotmail.com
authors.forename: Banu
authors.initials: B
authors.lastname: Lafci
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozsöyler
authors.forename: Mert
authors.initials: M
authors.lastname: Kestelli
authors.forename: Levent
authors.initials: L
authors.lastname: Yilik
authors.forename: Tayfun
authors.initials: T
authors.lastname: Göktogan
authors.forename: Nagihan
authors.initials: N
authors.lastname: Karahan
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozbek
authors.forename: Ali
authors.initials: A
authors.lastname: Gürbüz
mesh_terms: D000328:Adult; D001021:Aortic Valve; D017548:Echocardiography, Transesophageal; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D012189:Retrospective Studies; D016019:Survival Analysis; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery*