No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease.
Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.
Riemenschneider
M
M
Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-Munich, 81675 Munich, Germany. m.riemenschneider@lrz.tu-muenchen.de <m.riemenschneider@lrz.tu-muenchen.de>
Schoepfer-Wendels
A
A
Friedrich
P
P
Konta
L
L
Laws
S M
SM
Mueller
J C
JC
Kurz
A
A
Förstl
H
H
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D033921:Vesicular Transport Proteins / Q000235:genetics*
C498296:VPS26A protein, human; D033921:Vesicular Transport Proteins