[Effects of insulin on glucose metabolism in sepsis].
The study surveys potential effects of hyperglycemia on prognosis, complications and mortality of critical patients. Normalization of glycemia seems to be an effective therapeutic approach that influences morbidity and mortality of critical patients. Although insulin therapy has many positive effects, it is rather a way how to achieve normoglycemia. Authors present their own research of the impact of plasmatic insulin levels on glucose metabolism. It seems that the ability of critical patients to utilise and store glucose is significantly decreased due to their insulin resistance. Glucose oxidation is decreased only slightly. Glucose utilisation and oxidation in sepsis can be enhanced by administration of insulin.
Rusavý
Z
Z
Diabetologické a nutricní centrum, I. interní klinika Lékarské fakulty UK a FN, Plzen. Rusavy@fnplzen.cz
Lacigová
S
S
Jankovec
Z
Z
Zourek
M
M
Krcma
M
M
D001786:Blood Glucose / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose