[Biological investigation of thyroid cancer].
Thyroid carcinomas represent the most common endocrine malignancy, and several biological markers are proposed according to the different types of this cancer: for papillary cancer, thyroglobulin constitutes an excellent prognostic factor and rearrangements of ret oncogene can be useful in diagnosis. In sporadic medullary carcinoma, calcitonin is a diagnosis marker of choice, and coupled with ACE, can prevent relapse. Regarding familial medullary carcinoma, mutation screening in ret oncogene leads to early detection of new cases.
Douik
Hayet
H
Service de Biologie Clinique, Institut Salah Azaiez de Tunis.
Ghanem
Abderraouf
A
Jmal
Aouatef
A
Harzallah
Latifa
L
Gara
Samia
S
Abdennebi
Monia
M
Boussen
Hamouda
H
Guemira
Fethi
F
D014408:Biomarkers, Tumor / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015316:Genetic Therapy; D006801:Humans; D051096:Proto-Oncogene Proteins c-ret / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002116:Calcitonin; D013954:Thyroglobulin; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human