Unusual extramedullary recurrences and breast relapse despite hepatic GVHD after allografting in Ph+-ALL.
Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after BMT. Our report describes a case of an extramedullary recurrence and breast relapse after second-allografting in a female patient with Ph+-acute lymphoblastic leukemia (ALL), occurring when there was active hepatic GHVD. This case illustrates the complex relationship between graft-versus-host disease (GVHD) and graft-versus-leukemia since she had no evidence of leukemia in her marrow demonstrating 100% full-donor chimerism while she had ALL relapse in her breast.
Koca
Ebru
E
Hacettepe University, Division of Hematology, Department of Internal Medicine, Ankara, Turkey. ekoca@hacettepe.edu.tr
Goker
Hakan
H
Guven
Gulay S
GS
Cetiner
Deniz
D
Haznedaroglu
Ibrahim C
IC
Buyukasik
Yahya
Y
Uner
Aysegul
A
Ozcebe
Osman I
OI
D001940:Breast / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017254:Leukemic Infiltration / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D011289:Preleukemia / Q000628:therapy; D012074:Remission Induction