The association between multidrug resistance-1 gene polymorphisms and outcomes of allogeneic HLA-identical stem cell transplantation.
The impact of single nucleotide polymorphisms of two loci (C3435T and G2677T/A) of the multidrug resistance-1 gene (MDR1) was investigated in 82 patients undergoing allogeneic stem cell transplantation (SCT). The GG genotype on G2677T/A loci was associated with higher non-relapse mortality than was the non-GG genotype (67% vs. 32%, p=0.0073), but not the C3435T (p=0.2026) or MDR1 haplotype (p=0.2238). Accordingly, overall survival was significantly correlated with the G2677T/A genotype (p=0.0048). Multivariate analysis also showed that the GG genotype at G2677T/A had an unfavorable prognosis in terms of overall survival (p=0.003) and non-relapse mortality (p=0.031). In conclusion, the G2677T/A genotype seems to be associated with transplantation outcomes, especially non-relapse mortality.
Kim
Dong Hwan
DH
Department of Hematology/Oncology, Kyungpook National University Hospital, Jung-Gu, Daegu, Korea.
Park
Jae Yong
JY
Sohn
Sang Kyun
SK
Lee
Nan Young
NY
Suh
Jang Soo
JS
Lee
Kyu Bo
KB
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D019450:Genes, MDR; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D033581:Stem Cell Transplantation; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000276:immunology* / Q000401:mortality; D016896:Treatment Outcome
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004247:DNA