Suspected drug-induced destructive cholangitis in a young dog.
A nine-month-old miniature doberman was referred for the evaluation of chronic icterus. History and clinical and histopathological findings were supportive of a diagnosis of drug-induced destructive cholangitis. The main histopathological findings were canalicular, centrilobular cholestasis and ductopenia with moderate inflammatory infiltrate. The dog had received three types of treatment for demodicosis before the onset of jaundice. Amoxicillin-clavulanate, amitraz, milbemycin oxime or an interaction between two of the three drugs may have been responsible for the destructive cholangitis.
Gabriel
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A
Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.
van den Ingh
T S G A M
TS
Clercx
C
C
Peeters
D
D
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects; D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001774:Blood Chemical Analysis; D002761:Cholangitis / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D007306:Insecticides / Q000009:adverse effects; D018942:Macrolides / Q000009:adverse effects; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000662:veterinary; D014052:Toluidines / Q000009:adverse effects
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; D014052:Toluidines; C078973:milbemycin oxime; C014983:amitraz; D019980:Amoxicillin-Potassium Clavulanate Combination