title: Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation.
abstract: We report a case of severe hemorrhagic cystitis after allogeneic transplantation in association with high BK viral load. After failure of aggressive hydration, platelet and blood transfusions, continuous bladder irrigation, and tapering of the immune suppression, we instilled cidofovir into the bladder, which resulted in decreased BK viral load and significant clinical improvement. Our case suggests that local cidofovir therapy for viral hemorrhagic cystitis is effective and well tolerated with no observed side effects.
authors.affiliation: University of Maryland, Baltimore, 21201, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bridges
authors.forename: Sarah
authors.initials: S
authors.lastname: Donegan
authors.forename: Ashraf
authors.initials: A
authors.lastname: Badros
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001739:BK Virus; D000077404:Cidofovir; D003556:Cystitis / Q000209:etiology / Q000628:therapy*; D003596:Cytosine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage* / Q000009:adverse effects; D017713:Platelet Transfusion; D027601:Polyomavirus Infections / Q000209:etiology / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D011879:Radiotherapy Dosage; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir