title: Signal relay during the life cycle of Dictyostelium.
abstract: A fundamental property of multicellular organisms is signal relay, the process by which information is transmitted from one cell to another. The integration of external information, such as nutritional status or developmental cues, is critical to the function of organisms. In addition, the spatial organizations of multicellular organisms require intricate signal relay mechanisms. Signal relay is remarkably exhibited during the life cycle of the social amoebae Dictyostelium discoideum, a eukaryote that retains a simple way of life, yet it has greatly contributed to our knowledge of the mechanisms cells use to communicate and integrate information. This chapter focuses on the molecules and mechanisms that Dictyostelium employs during its life cycle to relay temporal and spatial cues that are required for survival.
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892, USA.
authors.forename: Dana C
authors.initials: DC
authors.lastname: Mahadeo
authors.forename: Carole A
authors.initials: CA
authors.lastname: Parent
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology; D017077:Culture Media, Conditioned; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000254:growth & development / Q000502:physiology*; D005492:Folic Acid / Q000378:metabolism; D006588:Hexanones / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D033761:Spores, Protozoan / Q000378:metabolism
chemical_list: D017077:Culture Media, Conditioned; D006588:Hexanones; D011953:Receptors, Cyclic AMP; C053433:1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; C017263:discadenine; D000641:Ammonia; D005492:Folic Acid; D000242:Cyclic AMP; D000225:Adenine