End points in clinical trials: are they moving the goalposts?
In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?
Leung
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French
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D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002986:Clinical Trials as Topic / Q000592:standards*; D001026:Coronary Artery Bypass / Q000379:methods; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D017751:Safety Management; D016896:Treatment Outcome