title: Expression of heat-shock protein 70 (Hsp70) in the respiratory tract and lungs of fire victims.
abstract: Immunohistochemical investigation of the respiratory tract and lungs of 63 fire victims revealed a statistically significant enhanced expression of heat-shock protein 70 (Hsp70) in the epiglottis, the trachea, and the main and the peripheral bronchi compared with a control group. In the fire victims, a strong expression of Hsp70 was discernible not only particularly in the vessels but also in seromucous secretory cells, ciliated epithelial cells, smooth muscle cells, and alveolar cells. The results suggest a vital or supravital reaction due to the inhalation of hot fire fumes.
authors.affiliation: Institute of Legal Medicine, Albert Ludwig University, Albertstrasse 9, 79104 Freiburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Marschall
authors.forename: M A
authors.initials: MA
authors.lastname: Rothschild
authors.forename: M
authors.initials: M
authors.lastname: Bohnert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002923:Cilia / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005390:Fires; D049429:Forensic Pathology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D012137:Respiratory System / Q000166:cytology / Q000378:metabolism*; D012704:Serous Membrane / Q000166:cytology / Q000378:metabolism; D015208:Smoke Inhalation Injury / Q000378:metabolism
chemical_list: D018840:HSP70 Heat-Shock Proteins