title: A novel approach to chronic total occlusions: the crosser system.
abstract: OBJECTIVE
  To evaluate safety and efficacy of the CROSSER CTO Recanalization System (CROSSER).
  
  
  BACKGROUND
  The CROSSER, a novel device dedicated to recanalization of chronic total occlusions (CTO), relies on a monorail catheter delivering vibrational energy to facilitate the crossing of occluded coronary arteries.
  
  
  METHODS
  We included de novo or restenotic occlusions in native coronary arteries with typically unfavorable characteristics and a prior failed guidewire attempt either performed in a previous procedure or just before the usage of the CROSSER. The end points analyzed were technical success (ability to cross or facilitate a guidewire crossing into the true lumen), angiographic success (<20% residual stenosis and TIMI flow grade 3), and clinical success (angiographic success and freedom from major adverse cardiac events at 30 days).
  
  
  RESULTS
  Twenty-eight patients (30 lesions) were included. The morphology was blunt in 83.3% and the length of the occlusion was >20 mm in 76.6%. The median age of the CTO was 9 months (range 3-60 months). Technical success was obtained in 19 (63%) occlusions and angiographic success in 16 (53%): 26.3% in lesions with prior procedural failure and 73.7% when CROSSER was attempted after initial guidewire failure. Complications were: one guidewire perforation without consequences and one peri-procedural myocardial infarction (MI). No events occurred within 30-day follow-up after discharge.
  
  
  CONCLUSIONS
  In our experience, the CROSSER System is safe and increases the success of opening CTO refractory to guidewires. This novel device may represent an useful adjunct to the armamentarium of the interventional cardiologist.
authors.affiliation: EMO Centro Cuore Columbus, Milan, Italy.
authors.forename: Gloria
authors.initials: G
authors.lastname: Melzi
authors.forename: John
authors.initials: J
authors.lastname: Cosgrave
authors.forename: Giuseppe L
authors.initials: GL
authors.lastname: Biondi-Zoccai
authors.forename: Flavio
authors.initials: F
authors.lastname: Airoldi
authors.forename: Iassen
authors.initials: I
authors.lastname: Michev
authors.forename: Alaide
authors.initials: A
authors.lastname: Chieffo
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Sangiorgi
authors.forename: Matteo
authors.initials: M
authors.lastname: Montorfano
authors.forename: Mauro
authors.initials: M
authors.lastname: Carlino
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000295:instrumentation*; D002908:Chronic Disease; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use*