title: The elastic properties of morsellised cortico-cancellous bone graft are dependent on its prior loading.
abstract: Confined compression experiments were carried out on cortico-cancellous bone taken from bovine femoral condyles to assess the effect of prior loading on the elastic confined modulus, E(c) of morsellised cortico-cancellous bone (MCB). Measurements were taken to find the values of E(c) for MCB subjected to cyclic loading resulting in axial stresses in the range of 0.5-3.0 N mm(2). Two values of E(c) were considered: E(ic), the instantaneous modulus, and E(dc), the delayed modulus allowing for stress relaxation effects. It was found that the values of E(c) increased with increasing maximum axial stress. It was also found that for each stress level the values of E(c) increased as the number of load cycles increased. The dependence of E(c) on the maximum axial stress and the number of load cycles is seen to explain the wide range of values for the apparent modulus of MCB found in previous studies. Tests examining the stress relaxation behaviour of MCB are also discussed. The results indicate that a minimum of 10 compaction episodes are required for MCB to achieve around 90% of its predicted maximum stiffness for a given compaction force.
authors.affiliation: School of Engineering and Electronics, The University of Edinburgh, Edinburgh, Scotland, UK. andrew.phillips@ed.ac.uk
authors.forename: A T M
authors.initials: AT
authors.lastname: Phillips
authors.lastname: Pankaj
authors.forename: D T
authors.initials: DT
authors.lastname: Brown
authors.forename: T Z
authors.initials: TZ
authors.lastname: Oram
authors.forename: C R
authors.initials: CR
authors.lastname: Howie
authors.forename: A S
authors.initials: AS
authors.lastname: Usmani
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D003198:Computer Simulation; D004548:Elasticity; D005269:Femur; D005270:Femur Head; D006801:Humans; D008954:Models, Biological; D013314:Stress, Mechanical; D013718:Tensile Strength; D016474:Weight-Bearing