title: State of central and peripheral pools of hemopoietic precursor cells in patients with malignant neoplasms during chemotherapy.
abstract: We studied toxic effects of various schemes of cytostatic treatment on central and peripheral pools of hemopoietic precursor cells in patients with III-IV stages of lung cancer and breast cancer. It was found that erythro- and granulomonocytopoietic precursors are characterized by high resistance to cytostatic treatment compared to morphologically discernible bone marrow elements, which is probably a evolutionary developed property of this cell type aimed at rapid recovery of the hemopoietic tissue.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
authors.forename: M G
authors.initials: MG
authors.lastname: Matyash
authors.forename: V V
authors.initials: VV
authors.lastname: Vysotskaya
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004912:Erythrocytes / Q000166:cytology; D005472:Fluorouracil / Q000627:therapeutic use; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil