"HURP on" we're off to the kinetochore!
RanGTP has a central role in spindle assembly, but the Ran-regulated factors required to initiate spindle bipolarity and stabilize MT growth toward the chromosomes remain unknown. However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties.
Wilde
Andrew
A
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology*; D048750:Cell Nucleus Division / Q000235:genetics / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000502:physiology*; D008941:Spindle Apparatus; D014981:Xenopus; D020931:ran GTP-Binding Protein / Q000502:physiology
D018797:Cell Cycle Proteins; C465041:DLGAP5 protein, human; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D020931:ran GTP-Binding Protein