title: Form I of desloratadine, a tricyclic antihistamine.
abstract: The title compound [systematic name: 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[4,5]cyclohepta[2,1-b]pyridine], C19H19ClN2, was crystallized from ethyl acetate. The interesting feature of the reported structure is that it does not contain any strong hydrogen bonds, although the molecule contains a secondary NH group, which is a good hydrogen-bond donor.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
authors.forename: Prashant M
authors.initials: PM
authors.lastname: Bhatt
authors.forename: Gautam R
authors.initials: GR
authors.lastname: Desiraju
mesh_terms: D018360:Crystallography, X-Ray; D006634:Histamine H1 Antagonists / Q000737:chemistry*; D006860:Hydrogen Bonding; D017336:Loratadine / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006634:Histamine H1 Antagonists; D017336:Loratadine; C121345:desloratadine