[Clinical observation on long-term surviving patients after combined abdominal organ transplantation].
OBJECTIVE
To summarize the treatment experience of long-term surviving patients after combined abdominal organ transplantation.


METHODS
From October 2001 to January 2005, 19 patients received combined abdominal organ transplantation in Nanfang Hospital, including 6 with simultaneous kidney-pancreas transplantation (SKPT), 12 with combined liver-kidney transplantation (CLKT), and 1 with simultaneous liver-pancreas transplantation (SLPT). The periods of follow up were from 6 months to 3 years and 8 months. Summarize primary diseases of the patients, factors which impacted on patients long-term survival rate, and immunological characteristics of combined abdominal organ transplantation.


RESULTS
All of 19 transplant cases were performed successfully. Among then, 18 were followed up; 16 survived till now; 2 patients undergoing liver-kidney transplantation were dead, one of which died from myocardial infarction in the 18 months after operation, and one died from cytomegalovirus in infection of lung in 13 months; 1 liver-kidney transplantation patient and 2 pancreas-liver transplantation patients experienced acute rejection once; 2 patients were found nephrotoxicity. Among the 18 patients, 4 patients' survival time were over 3 years, 7 over 2 years, 6 over 1 year, 1 over 10 months.


CONCLUSIONS
Combined abdominal organ transplantation is effective for treatment of two abdominal organ failure diseases. Factors which impact on patients long-term surviving include choosing suitable recipient, high quality of donated organ, avoidance of surgical complication, the history of myocardial infarction before operation, immunosuppressive regime and virus infection late after transplantation. Combined abdominal organ transplantation has some different immunological characteristics from single organ transplantation.
Yu
Li-xin
LX
Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yybright@yahoo.com.cn
Yu
Yu-ming
YM
Deng
Wen-feng
WF
Xu
Jian
J
Ye
Jun-sheng
JS
Fu
Shao-jie
SJ
Du
Chuan-fu
CF
Ye
Gui-rong
GR
Wang
Yi-bin
YB
Liu
Xiao-you
XY
Li
Chuan-jiang
CJ
Miao
Yun
Y
D000328:Adult; D000368:Aged; D004386:Duodenum / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000379:methods / Q000401:mortality; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000276:immunology / Q000379:methods / Q000401:mortality; D016896:Treatment Outcome