Anticoagulant modulation of blood cells and platelet reactivity by garlic oil in experimental diabetes mellitus.
Multiple blood cell types and metabolic pathways involved in the modulation of platelet reactivity were investigated in streptozotocin-induced diabetic rats treated with garlic oil. Platelet counts of diabetic rats treated with garlic oil were significantly (P<0.01) reduced as compared to diabetic control rats. Garlic oil also increased the leucocyte counts of diabetic rats as compared to diabetic control rats. The significant (P<0.001) decreases by garlic oil of plasma concentration factors, V, VII, VIII: C, IX and X in diabetic rats may be interpreted to mean that there was a modulation of factor VII similar to that brought about by thrombin on factors V and VIII: C. This reversal of hypercoagulation through integrated biochemical reaction is suggestive of multicellular modulation of platelet reactivity, erythrocytes and neutrophils and the functional interactions between plasma coagulation factors and platelet cofactors.
Ohaeri
O C
OC
Department of Biochemistry, Faculty of Medical Sciences, University of JOS, JOS, Nigeria. ohaeric2000@yahoo.co.uk
Adoga
G I
GI
D000818:Animals; D060829:Arthropod Proteins; D001773:Blood Cells / Q000187:drug effects*; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D004792:Enzyme Precursors / Q000032:analysis; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005737:Garlic; D007958:Leukocyte Count; D008297:Male; D010938:Plant Oils / Q000494:pharmacology*; D010976:Platelet Count; D051381:Rats; D012697:Serine Endopeptidases / Q000032:analysis
D060829:Arthropod Proteins; D004792:Enzyme Precursors; D010938:Plant Oils; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX; D005170:Factor X; D012697:Serine Endopeptidases; C057151:Limulus clotting factor C