Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine.
A reliable and high-yielding procedure for preparation of 7-aryl and 7-heteroaryl derivatives of (+/-)-vasicine in two steps from the naturally occurring material is described. This protocol broadens the chemical space for selective modifications of the vasicine tricyclic structure, thereby making it a valuable starting point for the development of novel compound libraries with potentially beneficial biological profiles.
Shevyakov
Sergey V
SV
Chemical Diversity Research Institute, Khimki, Moscow Reg., 114401 Russia.
Davydova
Olga I
OI
Pershin
Dmitry G
DG
Krasavin
Mikhail
M
Kravchenko
Dmitry V
DV
Kiselyov
Alex
A
Tkachenko
Sergey E
SE
Ivachtchenko
Alexandre V
AV
D000470:Alkaloids; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines
D000470:Alkaloids; D011799:Quinazolines; C019592:vasicine