title: Hypotension and transient renal impairment induced by lumbar puncture.
abstract: BACKGROUND
  Raised intracranial pressure (ICP) may induce hypertension through sympathetic mechanisms.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 55-year-old man was admitted with a symptomatic intracerebral mass and new refractory arterial hypertension. Several antihypertensive medications were necessary to control his blood pressure. A lumbar puncture was performed for diagnostic purposes and raised opening pressure (42 cm H2O) denoted raised ICP. After cerebrospinal fluid extraction, the closing pressure dropped to normal level. Shortly after the lumbar puncture, a sudden and pronounced drop in blood pressure was noted. Over the next day, the patient's serum creatinine rose from 0.9 to 1.9 mg/dL. Blood pressure normalized after discontinuation of all antihypertensive drugs and administration of intravenous fluids. Renal function also completely recovered within 2 days. The patient remained spontaneously normotensive thereafter.
  
  
  CONCLUSIONS
  Sudden hypotension may occur after lumbar puncture in patients with raised ICP receiving treatment for arterial hypertension.
authors.affiliation: Department of Neurology, Jackson Memorial Hospital, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Abiezer
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D001932:Brain Neoplasms / Q000175:diagnosis; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013129:Spinal Puncture / Q000009:adverse effects*