Contractile properties of standard and nerve-intact muscle grafts in the rat.
The contractile properties of standard and nerve-intact grafts of extensor digitorum longus muscles of rats were compared in vitro. Fourteen days after grafting, the time to peak tension and the half-relaxation times of nerve-intact grafts were shorter than those of standard grafts, but both were longer than control values. By 60 days, these variables attained normal values. At every sample period, the tetanic tensions of nerve-intact grafts were higher than those of standard grafts. Even at the early sampling periods, the twitch-tetanic tension ratios of nerve-intact grafts were close to normal values, whereas those of standard grafts were higher than normal. Stabilized nerve-intact grafts had a larger mass and greater maximum tetanic tension development than standard grafts, but were more fatigable. Compared with control EDL muscles, stable nerve-intact grafts show no differences except for lessened fatigability, whereas standard grafts demonstrate significant functional deficits.
Faulkner
J A
JA
Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.
Carlson
B M
BM
D000367:Age Factors; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000502:physiology* / Q000528:radiation effects; D009121:Muscle Denervation / Q000379:methods; D018763:Muscle Fatigue / Q000502:physiology / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000502:physiology* / Q000528:radiation effects / Q000637:transplantation*; D009417:Nerve Tissue / Q000502:physiology* / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors