title: Familial clustering in subgroups of gastric cancer stratified by histology, age group and location.
abstract: OBJECTIVE
  To assess the risk of gastric cancer in a Japanese patient population with the disease by stratification with histology, age, tumour location and the association with family history of gastric or non-gastric tumours.
  
  
  METHODS
  A retrospective analysis of 1400 consecutive patients with gastric cancer and 13,467 age- and gender-matched controls from a pre-recorded database using conditional logistic regression models.
  
  
  RESULTS
  Young patients (< or = 43 years of age) with gastric cancer of intestinal type had a strong association with family history of gastric cancer in first degree-relatives (OR=12.5). Moreover, when a history of gastric cancer was observed in both parents, there was an increased risk of gastric cancer intestinal type (OR=7.8), more commonly in the proximal and mid-stomach. In contrast, there was an increased risk of diffuse-type cancer when both parents suffered non-gastric cancers (OR=2.1).
  
  
  CONCLUSIONS
  These data suggest that the degree of familial clustering differ in gastric cancer subgroups stratified by histology, age, and stomach location in this Japanese population.
authors.affiliation: Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Eto
authors.forename: S
authors.initials: S
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Mitsumori
authors.forename: H
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: S
authors.initials: S
authors.lastname: Anazawa
authors.forename: K
authors.initials: K
authors.lastname: Yanaga
authors.forename: M
authors.initials: M
authors.lastname: Urashima
mesh_terms: D017677:Age Distribution; D016000:Cluster Analysis; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology