[Primary prevention of ischemic heart disease in middle-aged men living in Prague: results of twenty-year research].
BACKGROUND
Ischemic Heart Disease (IHD) represents the most frequent cause of mortality and morbidity in the Czech Republic. The aim of this study is to analyze long-term mortality of cardiovascular disease (CVD), identify its predictors and verify the validity of Framingham risk function for Czech patients.


METHODS
The twenty-year study (STULONG) of primary prevention of risk factors of atherosclerosis in 1419 men aged 38 to 53 years living in Prague was started in 1975.


RESULTS
CVD mortality analysis showed a higher risk of death for heavy smokers vs. non-smokers or light smokers (p < 0.0001), hypertensive patients vs. patients with normal blood pressure (p < 0.0001), men with hypercholesterolemia vs. men with normal cholesterol level (p = 0.0432), and a lower risk for university graduates vs. men with elementary education (p = 0.0006). Between 1980 and 1984, age-specific CVD mortality rates of men from STULONG study were higher (p = 0.0132) than national CVD mortality rates; between 1985 and 1994, they were insignificantly lower. Framingham risk function underestimated absolute ten-year risk of IHD in all risk quintiles (p < 0.0001) with discrimination of 63%.


CONCLUSIONS
CVD mortality observed within STULONG study was significantly affected by known risk factors (hypertension, smoking, hypercholesterolemia, lower education); Framingham risk function underestimated absolute ten-year risk of IHD.
Boudík
F
F
II. interní klinika 1. lékarské fakulty UK a VFN, Praha.
Reissigová
J
J
Hrach
K
K
Tomecková
M
M
Bultas
J
J
Anger
Z
Z
Aschermann
M
M
Zvárová
J
J
D003324:Coronary Artery Disease / Q000517:prevention & control*; D018153:Czech Republic; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control*; D011322:Primary Prevention; D012307:Risk Factors; D014505:Urban Population