title: Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects.
abstract: We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.
authors.affiliation: Department of Dermatology, Bichat-Claude Bernard University Hospital, Paris, France. emmanuel.mahe@apr.aphp.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mahé
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon
authors.forename: Sophie
authors.initials: S
authors.lastname: Lechaton
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Drappier
authors.forename: Yves
authors.initials: Y
authors.lastname: de Prost
authors.forename: Henri
authors.initials: H
authors.lastname: Kreis
authors.forename: Christine
authors.initials: C
authors.lastname: Bodemer
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus