title: Celiac disease prevalence in Brazilian dilated cardiomyopathy patients.
abstract: Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti-h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti-h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.
authors.affiliation: Service of Gastroenterology and Digestive Endoscopy, Clinical Hospital, Federal University of Paraná, Curitiba, Paraná, Brazil. ricsdebem@netpar.com.br
authors.forename: Ricardo Schmit T
authors.initials: RS
authors.lastname: De Bem
authors.forename: Shirley Ramos
authors.initials: SR
authors.lastname: Da Ro Sa Utiyama
authors.forename: Renato Mitsunori
authors.initials: RM
authors.lastname: Nisihara
authors.forename: Jerônimo Antônio
authors.initials: JA
authors.lastname: Fortunato
authors.forename: Josué Augusto
authors.initials: JA
authors.lastname: Tondo
authors.forename: Eliane Ribeiro
authors.initials: ER
authors.lastname: Carmes
authors.forename: Raquel Almada E
authors.initials: RA
authors.lastname: Souza
authors.forename: Julio César
authors.initials: JC
authors.lastname: Pisani
authors.forename: Heda Maria Barska Dos Santos
authors.initials: HM
authors.lastname: Amarante
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000276:immunology; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D015995:Prevalence
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A