Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.
Chen
Meng
M
Liu
Ke
K
Jiang
Yong-Tao
YT
Shen
Li
L
D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000378:metabolism*; D045785:Diterpenes, Clerodane / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants; D031363:Scutellaria / Q000378:metabolism*
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts