title: Circadian and ultradian (12 h) rhythms of hepatic thiosulfate sulfurtransferase (rhodanese) activity in mice during the first two months of life.
abstract: Thiosulfate sulfurtransferase (TST) is an important 'enzyme of protection,' that accelerates the detoxification of cyanide, converting it into thiocyanate. The TST physiological rhythm was investigated at wks 2, 4, and 8 of post-natal development (PND) in the mouse. The results revealed a statistically significant gender-related difference, with the highest activity in females, at all the documented PND stages. In the second week of PND (pre-weaning time), the circadian rhythm of the enzyme activity was associated with ultradian components. The prominent circadian rhythm (tau=24 h) peaked at the beginning of the light span, more precisely approximately 3 HALO (Hours After Light Onset). A week after weaning (wk 4 of PND), an impairment of the rhythm, with the peak shifted toward the second half of photophase, was recorded. Four to 6 wks later, about wk 8 of PND, the circadian rhythm pattern was stabilized, with its peak then located at the beginning of the dark span (13 HALO). The obtained results showed a 12 h phase-shift of the circadian TST peak time during PND, suggesting that the rhythm stabilization is age-dependent.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Tunisia.
authors.forename: Mamane
authors.initials: M
authors.lastname: Sani
authors.forename: Wafa
authors.initials: W
authors.lastname: Gadacha
authors.forename: Naceur A
authors.initials: NA
authors.lastname: Boughattas
authors.forename: Alain
authors.initials: A
authors.lastname: Reinberg
authors.forename: Mossadok
authors.initials: M
authors.lastname: Ben Attia
mesh_terms: D000204:Activity Cycles / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D017440:Photoperiod; D012727:Sex Characteristics; D013884:Thiosulfate Sulfurtransferase / Q000378:metabolism*
chemical_list: D013884:Thiosulfate Sulfurtransferase