Electrochemical characteristics of gatifloxacin and its interaction with DNA.
The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 x 10(5) (mol L(-1))(-1) and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit analysis of electrochemical data. The results demonstrate that GTFX has the properties of an intercalative binder.
Guo
Ming
M
Department of Chemistry, Zhejiang Forestry University, LinAn, China. tdky@hotmail.com
Yu
Qing-Sen
QS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001665:Binding Sites; D002244:Carbon; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D024841:Fluoroquinolones / Q000737:chemistry*; D000077734:Gatifloxacin; D008024:Ligands
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D008024:Ligands; D002244:Carbon; D004247:DNA; C427203:calf thymus DNA; D000077734:Gatifloxacin