title: Blood vessels engineered from human cells.
abstract: Human vascular tissue engineering has progressed substantially over the past decade. Issues remain as to the optimum culture scaffold and cell source that should be used for arterial regeneration. In addition, limitations in replicative life span of adult human cells as compared with young animal cells have made human vascular tissue engineering more challenging. Despite these obstacles, several strategies for generating replacement vessels have progressed to clinical trials.
authors.affiliation: Department of Anesthesia, Duke University, Durham, NC 27708, USA.
authors.forename: Zhaodi
authors.initials: Z
authors.lastname: Gong
authors.forename: Laura E
authors.initials: LE
authors.lastname: Niklason
mesh_terms: D000367:Age Factors; D000818:Animals; D001807:Blood Vessel Prosthesis; D001808:Blood Vessels; D001854:Bone Marrow Cells; D018929:Cell Culture Techniques / Q000379:methods* / Q000639:trends; D003094:Collagen; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
chemical_list: D003094:Collagen