[Regulation of cytokine production in inflammatory bowel disease].
Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.
Ferrero-Miliani
Laura
L
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C. laufer01@herlevhosp.kbhamt.dk
Seidelin
Jakob Benecidt
JB
Nielsen
Ole Haagen
OH
D020170:Caspase 1 / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis*; D004789:Enzyme Activation; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism
D016207:Cytokines; D046912:Multiprotein Complexes; D020170:Caspase 1