Anti-obesity effect of Pinellia ternata extract in Zucker rats.
Pinellia ternata is known as the herb effective in removing dampness-phlegm, one of the causes of obesity in traditional Korean medicine. Pinellia ternata water extract (PE) was fed to rats after mixing with diet once a day (400 mg x kg(-1)) for 6 weeks. We investigated its effect on the thermogenesis and fatty acids oxidation with obese Zucker rats. We also determined the gene expression of uncoupling protein 1 (UCP1), peroxisome proliferators-activated receptor alpha (PPARalpha), and PPARgamma coactivator 1alpha (PGC1alpha). The PE treatment lowered the levels of triglyceride and free fatty acids (p<0.05) in blood of the obese rats and the body weight was also reduced slightly. It was also observed that PE significantly increased the expression of both UCP1 mRNA in brown adipose tissue (BAT) (p<0.001) and PPARalpha and PGC1alpha mRNA in white visceral adipose tissue (WAT) (p<0.05 and p<0.001, respectively), which may cause a reduction of obesity. These results suggested that PE would be able to affect anti-obesity through thermogenesis and fatty acid oxidation.
Kim
Yoo-Jeong
YJ
Natural Products Research Institute and College of Pharmacy, Seoul National University, Jongno-gu, Seoul, Korea.
Shin
Young-Oh
YO
Ha
Young-Wan
YW
Lee
Sanghyun
S
Oh
Jae-Keun
JK
Kim
Yeong Shik
YS
D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D007473:Ion Channels / Q000235:genetics; D008297:Male; D055670:Medicine, Korean Traditional; D024101:Mitochondrial Proteins / Q000235:genetics; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D030021:Pinellia / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D016601:RNA-Binding Proteins / Q000235:genetics; D051381:Rats; D011924:Rats, Zucker; D022722:Thermogenesis / Q000187:drug effects; D014157:Transcription Factors / Q000235:genetics; D000071256:Uncoupling Protein 1
D019440:Anti-Obesity Agents; D005227:Fatty Acids; D007473:Ion Channels; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010936:Plant Extracts; C501429:Ppargc1a protein, rat; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C000604373:Ucp1 protein, rat; D000071256:Uncoupling Protein 1