title: [Prenatal diagnostics of birth defects in the Czech Republic--gestational week at the time of diagnosis].
abstract: AIM AND TYPE OF STUDY: A retrospective study and analysis of data on gestational week at the time of the birth defect diagnoses of both invasive and non-invasive type as well as on gestational week at the time of pregnancy termination in the Czech Republic over the 1996-2003 period.
  
  
  METHODS
  Data on prenatal diagnostics were obtained from particular departments of medical genetics. Data were collected for both birth defects as a total as well as for selected particular types: anencephaly, spina bifida, omfalocele, gastroschisis and Down syndrome. An analysis on gestational weeks at the time of diagnosis and/or pregnancy termination was performed.
  
  
  RESULTS
  Mean gestational week at the time of diagnosis was 19.49 for total birth defects and 20.02 for pregnancy termination. Corresponding values (diagnosis x termination) in gestational weeks were as follows: Anencephaly 17.01 and 17.69, spina bifida 19.41 and 19.68, omfalocele 17.64 and 17.99, gastroschisis 17.63 and 1836, Down syndrome 19.81 and 20.43.
  
  
  CONCLUSIONS
  Results of aggregate data analysis contribute to a better knowledge of different methods of prenatal diagnosis during different gestational periods. All values of mean gestational week at the time of diagnosis/pregnancy termination slightly decreased during the time of the study in all presented types of birth defects.
authors.affiliation: Ustav pro péci o matku a díte, Praha.
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: V
authors.initials: V
authors.lastname: Gregor
authors.forename: J
authors.initials: J
authors.lastname: Horácek
authors.forename: K
authors.initials: K
authors.lastname: Svetnicová
authors.forename: D
authors.initials: D
authors.lastname: Masátová
mesh_terms: D000013:Congenital Abnormalities / Q000175:diagnosis*; D018153:Czech Republic; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis