Constitutional pericentric inversion of chromosome 9 and hematopoietic recovery after allogeneic stem cell transplantation.
Recent reports suggest that hemopoietic stem cells with constitutional pericentric inversion of chromosome 9 [inv(9)] may be related to delayed engraftment or hemopoietic defect after stem cell transplantation (SCT). We conducted a retrospective study on five allogeneic SCT in which constitutional inv(9) was detected either in the donor or the recipient. The results showed that hematologic recovery was within the expected time range for all our patients. However, one patient exhibited decreasing blood counts between day +45 and +272 after transplantation, possibly due to protracted cytomegalovirus (CMV) infection and gansiclovir and imatinib treatment. Our findings suggest that constitutional inv(9) may not be associated with delayed hemopoietic recovery after SCT.
Manola
K N
KN
Laboratory of Health Physics and Environmental Hygiene, National Center for Scientific Research Demokritos, 15310 Aghia Paraskevi, Athens, Greece.
Harhalakis
N
N
Symeonidis
A
A
Rigana
H
H
Stavropoulou
C
C
Karakasis
D
D
Tiniakou
M
M
Baltathakis
I
I
Stamouli
M I
MI
Zoumbos
N
N
Pantelias
G E
GE
Sambani
C
C
D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D001549:Benzamides; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology; D015774:Ganciclovir; D006402:Hematologic Diseases / Q000150:complications / Q000235:genetics / Q000628:therapy; D006410:Hematopoiesis / Q000187:drug effects / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000008:administration & dosage; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D020127:Recovery of Function / Q000187:drug effects / Q000235:genetics; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D013997:Time Factors; D014184:Transplantation, Homologous
D000998:Antiviral Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D015774:Ganciclovir