Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes.
OBJECTIVE
To determine the minimally modified electronegative LDL (LDL-) and its autoantibodies in coronary syndromes.


METHODS
LDL(-) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL- (microg/mL) and anti-LDL(-) IgG (OD405 nm).


RESULTS
The concentrations of LDL(-) were higher in patients with coronary disease (ACS: 40.7 microg/mL; SA: 35.0 microg/mL) as compared to controls (21.6 microg/mL). The highest LDL- concentrations were found in patients with AMI (41.8 microg/mL). Anti-LDL(-) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL- IgG and CRP levels (r = 0.34, p <0.01) in the studied groups.


CONCLUSIONS
LDL(-) and anti-LDL(-) autoantibodies may be useful markers to follow patients with high risk for coronary events.
Oliveira
Jair A
JA
Centro de Ciências da Saúde, Universidade Estadual de Londrina, Brazil.
Sevanian
Alex
A
Rodrigues
Ricardo J
RJ
Apolinário
Elaine
E
Abdalla
Dulcineia S P
DS
D000328:Adult; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000276:immunology; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology; D011237:Predictive Value of Tests
D001323:Autoantibodies; D015415:Biomarkers; D008077:Lipoproteins, LDL