title: Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis.
abstract: Three HIV-1-seronegative patients with disseminated tuberculosis presented significant depletion of T-cell counts, in CD4+ and/or CD8+ cells, associated with increased expression of activation marker CD38 on CD8+ T-lymphocytes. This finding raises the question of potential mechanisms involved in the activation or loss of T-cells in disseminated tuberculosis.
authors.affiliation: Infectious Diseases Division, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Denise Silva
authors.initials: DS
authors.lastname: Rodrigues
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Salomão
authors.forename: Esper Georges
authors.initials: EG
authors.lastname: Kallas
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology*; D000328:Adult; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology*
chemical_list: D051997:ADP-ribosyl Cyclase 1