A new radical scavenging anthracene glycoside, asperflavin ribofuranoside, and polyketides from a marine isolate of the fungus microsporum.
A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), and citrinin (4) have been isolated from the marine-derived fungus Microsporum sp. The structure and absolute stereochemistry of a new compound (1) was assigned on the basis of physicochemical data. Compounds 1-3 exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC(50) values of 14.2, 11.3, and 11.5 microM, respectively, which are more potent than the positive control, ascorbic acid (IC(50), 20 microM). Compound 1 also showed a moderate antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC value of 50 microg/ml.
Li
Yong
Y
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Li
Xifeng
X
Lee
Uk
U
Kang
Jung Sook
JS
Choi
Hong Dae
HD
Sona
Byeng Wha
BW
D000873:Anthracenes / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology; D008386:Marine Biology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000737:chemistry*; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology*
D000873:Anthracenes; D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D010851:Picrates; C002455:asperflavin; C004931:1,1-diphenyl-2-picrylhydrazyl; C034020:anthracene