title: Novel low-grade glioneuronal neoplasm presenting in an octogenarian: case report and review of the literature.
abstract: Glioneuronal neoplasms are rare tumors that typically affect patients in the first three decades of life. Since the publication of the World Health Organization (WHO) 2000 classification of tumors, further variants of these tumors have been reported. We present an 83-year-old gentleman who presented with a history of ataxia and weight loss. MRI and CT scan revealed a ring-enhancing bihemispheric lesion in the premotor cortex consistent with a malignant primary brain tumor crossing the corpus collosum. The patient underwent a sterotactic biopsy with drainage of the cystic component. Histopathologic studies revealed a mixed glioneuronal tumor with benign characteristics. A craniotomy was performed and the tumor was resected. Postoperatively, the patient has been followed with serial MRI scans with no evidence of disease recurrence at 27 months. Glioneuronal tumors are extremely uncommon in the octogenarian population, however, it is important to include them in the differential diagnosis of intracerebral masses. They are histopathologically quite heterogeneous, and in this report we present a novel subtype. Radiographically, these lesions can mimic more aggressive primary brain tumors.
authors.affiliation: Department of Neurological Sciences, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 E. 68th Street, Box #99, New York, NY 10021, USA.
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Mark A
authors.initials: MA
authors.lastname: Edgar
authors.forename: Neal
authors.initials: N
authors.lastname: Luther
authors.forename: Theodore H
authors.initials: TH
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018193:Neoplasms, Complex and Mixed / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D014057:Tomography, X-Ray Computed