Hyperimmunoglobulin E syndrome (job syndrome) discovered in a patient following corrective spine surgery: case report and review of the literature.
METHODS
A case report of the hyperimmunoglobulin E syndrome (Job syndrome) presenting in the context of late postoperative infection after corrective surgery for scoliosis.


OBJECTIVE
To describe the clinical presentation and treatment of a patient with Job syndrome, and its implications for spine surgeons.


BACKGROUND
Job syndrome classically presents with a triad of increased serum immunoglobulin E, multiple abscesses, and pneumonia with pneumatocele formation. In recent years nonimmunologic manifestations have been described, including scoliosis, joint hypermobility, eosinophilia, and atopy.


METHODS
A 15-year-old female presented with local swelling and fever 2 years after anterior lumbar discectomy and fusion with spinal instrumentation involving T11-L3 levels. Computerized tomography revealed paravertebral, psoas, and pulmonary abscesses. The implants were removed and antibiotic therapy instituted. Further investigation revealed features of the hyperimmunoglobulin E syndrome (Job syndrome).


RESULTS
The patient's symptoms resolved, as did markers of inflammation.


CONCLUSIONS
Job syndrome is a primary immunodeficiency often associated with scoliosis. Given the implications for surgical outcome in immunodeficient patients, the diagnosis should be considered and, blood tests instituted in patients with scoliosis with any of the associated history and physical findings of Job syndrome.
Tan
Wu Meng
WM
Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore. wumeng@cantab.net
Kandiah
David Arumaisingam
DA
Tan
Seang Beng
SB
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D020878:Device Removal; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications / Q000188:drug therapy; D016268:Internal Fixators; D007589:Job Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D011183:Postoperative Complications; D012600:Scoliosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D013123:Spinal Fusion; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents