title: Molecular mechanisms of metastasis.
abstract: A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.
authors.affiliation: Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA. hoon@jwci.org
authors.forename: Dave S B
authors.initials: DS
authors.lastname: Hoon
authors.forename: Minoru
authors.initials: M
authors.lastname: Kitago
authors.forename: Joseph
authors.initials: J
authors.lastname: Kim
authors.forename: Takuji
authors.initials: T
authors.lastname: Mori
authors.forename: Adriano
authors.initials: A
authors.lastname: Piris
authors.forename: Katherine
authors.initials: K
authors.lastname: Szyfelbein
authors.forename: Martin C
authors.initials: MC
authors.lastname: Mihm
authors.forename: S David
authors.initials: SD
authors.lastname: Nathanson
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Padera
authors.forename: Ann F
authors.initials: AF
authors.lastname: Chambers
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Vantyghem
authors.forename: Ian C
authors.initials: IC
authors.lastname: MacDonald
authors.forename: Steven C
authors.initials: SC
authors.lastname: Shivers
authors.forename: Marwan
authors.initials: M
authors.lastname: Alsarraj
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Reintgen
authors.forename: Bernward
authors.initials: B
authors.lastname: Passlick
authors.forename: Wulf
authors.initials: W
authors.lastname: Sienel
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
mesh_terms: D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology; D008207:Lymphatic Metastasis / Q000473:pathology / Q000503:physiopathology*; D008208:Lymphatic System / Q000503:physiopathology*; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D018715:Microscopy, Video; D009362:Neoplasm Metastasis / Q000473:pathology / Q000503:physiopathology*; D009857:Oncogenes / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology; D015398:Signal Transduction; D042582:Vascular Endothelial Growth Factor C / Q000502:physiology
chemical_list: D019707:Receptors, Chemokine; D042582:Vascular Endothelial Growth Factor C