P-bodies react to stress and nonsense.
P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress. Meanwhile, Sheth and Parker (2006) report that aberrant mRNAs are targeted to P-bodies to undergo rapid decay.
Bruno
Ivone
I
Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.
Wilkinson
Miles F
MF
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D027201:Cationic Amino Acid Transporter 1 / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D018389:Codon, Nonsense; D022083:Cytoplasmic Structures / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D011485:Protein Binding; D014176:Protein Biosynthesis; D020365:RNA Helicases / Q000235:genetics / Q000378:metabolism*; D020871:RNA Stability; D034443:RNA Transport; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D027201:Cationic Amino Acid Transporter 1; D018389:Codon, Nonsense; D035683:MicroRNAs; C092470:NMD2 protein, S cerevisiae; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C420825:SLC7A1 protein, human; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; C096360:UPF3 protein, S cerevisiae; D020365:RNA Helicases; C101828:UPF1 protein, human