title: Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors.
abstract: We report an unusual case of osteonecrosis of the femoral head associated with recurrent myopathy and bone abnormalities in a two-year-old girl, in whom symptoms occurred after a ten-day course of oral betamethasone for infectious wheezy bronchitis, and eventually recurred and were worsened by topical treatment; a hypersensitivity to glucocorticoids is hypothesised.
authors.affiliation: Department of Reproductive and Developmental Science and IRCCS, Istituto per I'Infanzia Burlo Garofolo, Clinica Pediatrica, Trieste, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Drigo
authors.forename: Alessia
authors.initials: A
authors.lastname: Saccari
authors.forename: Egidio
authors.initials: E
authors.lastname: Barbi
authors.forename: Fiora
authors.initials: F
authors.lastname: Bartoli
authors.forename: Giuliana
authors.initials: G
authors.lastname: Decorti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ventura
mesh_terms: D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D001991:Bronchitis / Q000188:drug therapy; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D001623:Betamethasone