title: Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.
abstract: The authors conducted a double-blind, placebo-controlled, crossover study to investigate the efficacy of oral zolmitriptan in the treatment of migraine in children and adolescents. Patients (n = 32) received placebo, zolmitriptan 2.5 mg, and ibuprofen 200 to 400 mg to treat three consecutive migraine attacks. Pain relief rates after 2 hours were 28% for placebo, 62% for zolmitriptan, and 69% for ibuprofen (p < 0.05). Both drugs are well tolerated with only mild side effects.
authors.affiliation: Department of Neurology, University of Münster, Germany. everss@uni-muenster.de
authors.forename: S
authors.initials: S
authors.lastname: Evers
authors.forename: A
authors.initials: A
authors.lastname: Rahmann
authors.forename: C
authors.initials: C
authors.lastname: Kraemer
authors.forename: G
authors.initials: G
authors.lastname: Kurlemann
authors.forename: O
authors.initials: O
authors.lastname: Debus
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
authors.forename: A
authors.initials: A
authors.lastname: Frese
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000188:drug therapy*; D023303:Oxazolidinones / Q000009:adverse effects / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D014363:Tryptamines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D023303:Oxazolidinones; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C089750:zolmitriptan; D007052:Ibuprofen