title: Past chlamydial infection is not associated with primary fallopian tube carcinoma.
abstract: We conducted a retrospective seroepidemiological study to evaluate the relationship between past chlamydial infection and primary fallopian tube carcinoma (PFTC). Postoperative serum samples were drawn from 79 consecutive patients treated for PFTC in 1985-2000. For each case two controls were selected. Serum samples were analysed for IgG antibodies to different C. trachomatis serotype pools and to C. pneumoniae. Seropositivity in general or serum antibody levels to different C. trachomatis serovars or C. pneumoniae did not differ between PFTC patients and controls. The lack of association between anti-chlamydial antibodies and PFTC suggests that past chlamydial infection does not play a role in the etiopathogenesis of PFTC. However, because chlamydial infection is common at young age and PFTC develops decades later, we cannot definitively exclude the possibility that C.trachomatis contributes to the development of PFTC.
authors.affiliation: Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Finland. annika.riska@hus.fi
authors.forename: A
authors.initials: A
authors.lastname: Riska
authors.forename: P
authors.initials: P
authors.lastname: Finne
authors.forename: H
authors.initials: H
authors.lastname: Alfthan
authors.forename: T
authors.initials: T
authors.lastname: Anttila
authors.forename: J
authors.initials: J
authors.lastname: Jalkanen
authors.forename: T
authors.initials: T
authors.lastname: Sorvari
authors.forename: U H
authors.initials: UH
authors.lastname: Stenman
authors.forename: J
authors.initials: J
authors.lastname: Paavonen
authors.forename: A
authors.initials: A
authors.lastname: Leminen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000032:analysis; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005185:Fallopian Tube Neoplasms / Q000382:microbiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000942:Antigens, Bacterial