title: [Duodenal gastrointestinal stromal tumors. Report of a case].
abstract: Gastrointestinal stromal tumors (GIST) are lesions whose diagnosis and treatment have varied in the last decade. We report a 76 year-old male with a history of eight episodes of upper gastrointestinal bleeding. A duodenography showed an elevated lesion in the third portion of the duodenum with a central ulceration. It was initially managed with tumorectomy and primary closure of the duodenum. The pathological study of the surgical specimen revealed a low grade gastrointestinal stromal tumor. Three years later, the tumor recurred and pancreatoduodenectomy was performed. Due to the high risk of malignant potential, tumor size, number of mitoses and the presence of necrosis, imatinib mesylate was started. The patient had a satisfactory evolution, without evidences of recurrence after 15 months of follow up.
authors.affiliation: Departamento de Cirugía, Facultad de Medicina, Universidad de Chile (Campus Oriente) Santiago de Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Carvajal H
authors.forename: Sebastián
authors.initials: S
authors.lastname: Iturra U
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Justiniano P
authors.forename: Marco
authors.initials: M
authors.lastname: Bustamante Z
authors.forename: Juan Eduardo
authors.initials: JE
authors.lastname: Contreras P
authors.forename: Juan
authors.initials: J
authors.lastname: Lombardi S
authors.forename: María
authors.initials: M
authors.lastname: Capetillo Fuentes
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D004379:Duodenal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D016577:Pancreaticoduodenectomy; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit; D011743:Pyrimidines / Q000627:therapeutic use; D011859:Radiography; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit