Reproducibility of the adrenal androgen response to adrenocorticotropic hormone stimulation.
Eleven healthy, eumenorrheic, nonhirsute women underwent acute adrenal stimulation testing at monthly intervals in order to measure the responses of cortisol (F), DHEA, and androstenedione, to a 60-minute acute stimulation with 1.0 mg ACTH (1-24). When the women were subdivided into either high or low responders to ACTH stimulation (relative to the group median), the relative adrenocortical response within individual subjects was found to be highly constant over time.
Ghadir
Shahin
S
Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Azziz
Ricardo
R
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D017697:Premenopause; D012016:Reference Values; D015203:Reproducibility of Results
D000728:Androgens; D006728:Hormones; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone