[Antiretroviral treatment associated life-threatening adverse events].
The primary goal of the highly active antiretroviral treatment is to improve HIV-infected patient immune function through maintaining viral suppression. However, this treatment may lead to adverse events, some of them potentially serious. This article emphasizes on the antiretroviral therapy associated adverse events and their management recommendations, especially for serious or potentially life-threatening cases. Adverse events analyzed in this article include side effects derived from mitochondrial toxicity, abacavir hypersensitivity reaction, hepatotoxicity, skin rash and Stevens-Johnson syndrome, increased bleeding episodes in hemophilic patients and nephrotoxicity. In some cases, a high suspicion is needed because the onset symptoms may be unspecific.
Moreno-Cuerda
Víctor Julián
VJ
Unidad VIH, Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, España. vjmorenocuerda@yahoo.es
Morales-Conejo
Montserrat
M
Rubio
Rafael
R
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use; D005076:Exanthema / Q000139:chemically induced; D015658:HIV Infections / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced; D017240:Mitochondrial Myopathies / Q000139:chemically induced / Q000453:epidemiology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D000099227:Abacavir
D015224:Dideoxynucleosides; D000099227:Abacavir