title: Electrical brain activity and response to olanzapine in schizophrenia: a study with LORETA images of P300.
abstract: The aim of this study was to evaluate the change in the distribution for the P300 generator, as demonstrated by Low Resolution Electromagnetic Tomography (LORETA) images, in patients with schizophrenia during treatment with olanzapine. Data were obtained from five right-handed patients treated with olanzapine for 6 months. Five right-handed normal volunteers also participated in the study. LORETA images of P300 in response to the odd-ball auditory discrimination task revealed a left dominant lateralized high current source density in the temporal lobes in all control subjects. Although this pattern of brain activation was not evident in patients at baseline, 6-month treatment with olanzapine recovered the left dominant pattern of the electrical density in the temporal regions, such as the Heschl gyrus, and improved performance on a test of verbal learning and memory. Scores of the Brief Psychiatric Rating Scale and the Global Assessment of Functioning Scale also improved during treatment. These results provide the first suggestion that enhancement of verbal memory and the functional status by treatment with some antipsychotic drugs may be associated with modulations of the anatomical configuration of electrical brain activity in patients with schizophrenia.
authors.affiliation: Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan. sumiyo@med.u-toyama.ac.jp <sumiyo@med.u-toyama.ac.jp>
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Higuchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Mie
authors.initials: M
authors.lastname: Matsui
authors.forename: Kanade
authors.initials: K
authors.lastname: Kato
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yuuki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Arai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine