title: Neutral wrist splinting in carpal tunnel syndrome: a 3- and 6-months clinical and neurophysiologic follow-up evaluation of night-only splint therapy.
abstract: OBJECTIVE
  The aim of the study was to evaluate the long-term efficacy of night-only splint wear therapy for carpal tunnel syndrome (CTS).
  
  
  METHODS
  We conducted a randomized case-control trial with evaluation after three and six months of follow-up of outpatients with mild, recent onset symptoms of CTS recruited from the department clinic. Fifty patients (50 hands) were enrolled, of which 36 completed the study at 6 months. The case group utilized a thermoplastic neutral wrist splint for night-only wear. Outcome measures were instrumental parameters (sensory and motor nerve conduction velocity), symptom and function alterations (as measured by Levine's self-administered questionnaire), clinical parameters (pressure-provocative and Phalen tests).
  
  
  RESULTS
  Improvements were observed in Levine's symptom status score at the three-month (P=0.001) and the six-month (P=0.001) follow-up visits, in functional score (P=0.0001) and (P=0.0004), in median distal sensory latency (P=0.01) and (P=0.02), in pressure-provocative test outcome (P=0.01) and (P=0.003), in Phalen test outcome (P=0.04) and (P=0.05) respectively.
  
  
  CONCLUSIONS
  Symptom relief and neurophysiological improvement after night-only splint wear therapy lasted up to the six-month follow-up visit.
authors.affiliation: Unit of Neurorehabilitation, Trabattoni-Ronzoni Hospital, Seregno, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Premoselli
authors.forename: P
authors.initials: P
authors.lastname: Sioli
authors.forename: A
authors.initials: A
authors.lastname: Grossi
authors.forename: C
authors.initials: C
authors.lastname: Cerri
mesh_terms: D002349:Carpal Tunnel Syndrome / Q000503:physiopathology / Q000534:rehabilitation*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D013165:Splints; D011795:Surveys and Questionnaires; D016896:Treatment Outcome