title: The effect of the cut surface during electrical stimulation of a cardiac wedge preparation.
abstract: Optical mapping from the cut surface of a "wedge preparation" allows observation inside the heart wall, below the epicardium or endocardium. We use numerical simulations based on the bidomain model to illustrate how the transmembrane potential is influenced by the cut surface. The distribution of transmembrane potential around a unipolar cathode depends on the fiber angle. For intermediate angles, hyperpolarization appears on only one side of the electrode, and is large and widespread.
authors.affiliation: Department of Physics, Oakland University, Rochester, MI 48309-4487, USA. roth@oakland.edu
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Roth
authors.forename: Salil G
authors.initials: SG
authors.lastname: Patel
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Murdick
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D016477:Artifacts; D018780:Body Surface Potential Mapping / Q000379:methods*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002478:Cells, Cultured; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology; D046509:Tissue Culture Techniques / Q000379:methods*