title: CD7/CD19 double-positive T-cell acute lymphoblastic leukemia.
abstract: We report a rare case of T-cell acute lymphoblastic leukemia (T-ALL) with an aberrant phenotype. A 52-year-old man was admitted to our hospital because of lymph node (LN) swelling in the bilateral neck. A computed tomographic scan showed LN swelling in the mediastinum and a right pleural effusion. The tumor cells in the neck LN showed positivity for cytoplasmic CD3, CD7, CD19, and CD79a, whereas the tumor cells in the bone marrow (BM) showed positivity for CD10 and CD13 in addition to the former 4 antigens. The chromosomes in the BM were normal. Neither T-cell receptor gamma nor immunoglobulin heavy chain rearrangement was detected in the neck LN. We diagnosed this case as T-ALL with an aberrant phenotype and started the standard chemotherapy for ALL. The response was so effective that complete remission (CR) was easily attained. The patient is now under maintenance therapy in the first CR without hematopoietic cell transplantation.
authors.affiliation: Department of Hematology, Hamamatsu Medical Center, Hamamatsu, Japan. shinfuji@hmedc.or.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Fujisawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tanioka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Takachika
authors.initials: T
authors.lastname: Ozawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Naito
authors.forename: Masahide
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D018941:Antigens, CD19; D019011:Antigens, CD7; D018572:Disease-Free Survival; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D011859:Radiography; D012074:Remission Induction
chemical_list: D018941:Antigens, CD19; D019011:Antigens, CD7