title: Studies toward soraphen A: an aldol-metathesis avenue to the macrocyclic framework.
abstract: [reaction: see text] We describe a convergent approach to soraphen A, 1, that involves coupling of two fragments by an aldol condensation-olefin metathesis sequence. This route permits rapid access to congeners of 1.
authors.affiliation: Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, Villeurbanne, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vincent
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Mansfield
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ciufolini
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; C086151:soraphen A