title: Role of complement component C5 in cerebral ischemia/reperfusion injury.
abstract: We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic C5 inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury.
authors.affiliation: Department of Preclinical Sciences, Alexion Pharmaceuticals Inc., Cheshire, CT 06410, USA. ccosta@iro.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Costa
authors.forename: Limin
authors.initials: L
authors.lastname: Zhao
authors.forename: Yamin
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiao
authors.initials: X
authors.lastname: Su
authors.forename: Liming
authors.initials: L
authors.lastname: Hao
authors.forename: Sean P
authors.initials: SP
authors.lastname: Colgan
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Stahl
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001929:Brain Edema / Q000473:pathology; D002545:Brain Ischemia / Q000473:pathology*; D050577:Complement C3-C5 Convertases / Q000037:antagonists & inhibitors; D003182:Complement C5 / Q000502:physiology*; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*
chemical_list: D019138:Antibodies, Blocking; D000911:Antibodies, Monoclonal; D003182:Complement C5; D018836:Inflammation Mediators; D050577:Complement C3-C5 Convertases