Maturity-onset diabetes of the young with necrobiosis lipoidica and granuloma annulare.
We describe a 12-year-old white girl with granuloma annulare localized to both ankles since she was five, necrobiosis lipoidica in the left pretibial region since she was ten, and a recent history of weakness, migraine, and weight loss. After initial evaluation, high fasting blood glucose levels and high hemoglobin A1c were found. The family history for non-insulin-dependent diabetes was suggestive of maturity-onset diabetes of the young. Coexistence of necrobiosis lipoidica and granuloma annulare, together with a family history of non-insulin-dependent diabetes, the age of onset, and the absence of ketosis, are specific features making possible, a clinical diagnosis. Genetic confirmation may not be so easily accessible or necessary.
Marchetti
Federico
F
Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy. fedemarche@tin.it
Gerarduzzi
Tania
T
Longo
Filippo
F
Faleschini
Elena
E
Ventura
Alessandro
A
Tonini
Giorgio
G
D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D016460:Granuloma Annulare / Q000209:etiology*; D006801:Humans; D009335:Necrobiosis Lipoidica / Q000209:etiology*