title: [The significance of diet and associated factors in psoriasis].
abstract: Psoriasis is a T cell mediated inflammatory skin disease characterized by hyperproliferation and reduced differentiation of epidermal keratinocytes. In severe cases, the disease can result in an insufficient nutritional status which may even be promoted by nutrient-drug interactions. Both the general diet and single food components have been suggested to play a role in etiology and pathogenesis of psoriasis. Fasting periods, vegetarian diets, and diets rich in omega-3 polyunsaturated fatty acids from fish oil have all been associated with improvement in some studies. The most likely explanation is the reduced amounts of arachidonic acid and the increased eicosapentaenoic acid intake resulting in a modulated eicosanoid profile. However, only one of four controlled studies showed a benefit of omega-3 fatty acids compared to placebo. Some psoriasis patients are gluten-sensitive and may benefit from a gluten free diet. The active form of vitamin D exhibits anti-proliferative and immunoregulatory effects and has been shown to be useful in the treatment of psoriasis.
authors.affiliation: Abteilung Ernährungsphysiologie und Humanernährung, Institut für Lebensmittelwissenschaft, Zentrum Angewandte Chemie, Universität Hannover, Hannover, Germany. maike.wolters@lw.uni-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Wolters
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects; D000975:Antioxidants / Q000627:therapeutic use; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D018849:Controlled Clinical Trials as Topic; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014676:Diet, Vegetarian; D002149:Energy Intake; D005215:Fasting; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005260:Female; D005395:Fish Oils; D018565:Food-Drug Interactions; D005983:Glutens / Q000009:adverse effects; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D009752:Nutritional Status; D011565:Psoriasis / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D012737:Sex Factors; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D003879:Dermatologic Agents; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D006710:Homocysteine; D014807:Vitamin D; D005983:Glutens; D008727:Methotrexate