Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation.
From the cultured cells of Panax notoginseng, a kind of ginseng saponin-ginsenoside Rg2, was separated and purified, and its structure was elucidated as 6-O-[alpha-L-rhamnose (l-->2)-beta-D-glucopyranosyl]3beta, 12beta, 20(S)-trihydroxydammar-24-ene [20(S)-ginsenoside Rg2]. Moreover, its bioactivity stimulates human umbilical cord vein endothelial cell proliferation; the growth of the cells treated with 20(S)-ginsenoside Rg2 was 14-fold higher than that of untreated ones, and the level of the cell's plasminogen activator (PA) was also twofold higher.
Xin
Xiujuan
X
State Key laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, P.R. China.
Liu
Jianwen
J
Li
Xiqiang
X
Zhong
Jianjiang
J
Wei
Dongzhi
D
D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects*; D036145:Ginsenosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D005894:Panax; D010960:Plasminogen Activators / Q000187:drug effects*; D014470:Umbilical Cord / Q000187:drug effects
D036145:Ginsenosides; C026474:ginsenoside Rg2; D010960:Plasminogen Activators