title: Human metapneumovirus infection in a hematopoietic stem cell transplant recipient with relapsed multiple myeloma and rapidly progressing lung cancer.
abstract: Human metapneumovirus (HMPV) was isolated from a 63-year-old multiple myeloma patient who had undergone hematopoietic stem cell transplantation and who presented with lower respiratory tract infection several weeks prior to the diagnosis of lung cancer. The isolate was phylogenetically and biologically characterized and compared to HMPV prototypes and recent pediatric isolates. Remarkably, it belonged to the novel genomic subgroup A2b.
authors.affiliation: Department of Virology, Institute for Medical Microbiology and Hygiene, University Hospital Freiburg, Freiburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Huck
authors.forename: M
authors.initials: M
authors.lastname: Egger
authors.forename: H
authors.initials: H
authors.lastname: Bertz
authors.forename: G
authors.initials: G
authors.lastname: Peyerl-Hoffman
authors.forename: W V
authors.initials: WV
authors.lastname: Kern
authors.forename: D
authors.initials: D
authors.lastname: Neumann-Haefelin
authors.forename: V
authors.initials: V
authors.lastname: Falcone
mesh_terms: D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D029121:Metapneumovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D018184:Paramyxoviridae Infections / Q000175:diagnosis / Q000821:virology*; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000821:virology*; D014709:Vero Cells; D014779:Virus Replication