Effect of artificial lung compliance on in vivo pulmonary system hemodynamics.
This study examined the effect of artificial lung compliance (C) on pulmonary system (PS) impedance and right ventricular function during in-series attachment of the MC3 Biolung in adult sheep. Compliances, C, of 0-20 ml/mm Hg were tested at the Biolung inlet. Results indicate the PS 0 harmonic input impedance modulus was not affected by C. The PS first harmonic input impedance modulus (Z1) was 10.9 +/- 3.2 mm Hg/(l/min) at C = 0 ml/mm Hg and minimized to 2.41 +/- 0.79 mm Hg/(l/min) at C > or = 0.5 ml/mm Hg. Cardiac output was 58% +/- 10% of its pre-Biolung attachment, baseline value at C = 0 ml/mm Hg and was maximized to an average of 75% +/- 11% at C > or = 0.5 ml/mm Hg. The left ventricular lateral-to-anteroposterior axis length ratio, which decreases with leftward septal shift, increased with C from 0.52 +/- 0.12 at C = 0 ml/mm Hg to 0.76 +/- 0.06 at C = 5 ml/mm Hg (p < 0.05), but decreased slightly with C at C > 5 ml/mm Hg. Therefore, the ideal C for right ventricular function is at least 0.5 ml/mm Hg and may be as high as 5 ml/mm Hg to minimize septal shift.
Sato
Hitoshi
H
Department of Surgery and Bioengineering, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
McGillicuddy
John W
JW
Griffith
Grant W
GW
Cosnowski
Amy M
AM
Chambers
Sean D
SD
Hirschl
Ronald B
RB
Bartlett
Robert H
RH
Cook
Keith E
KE
D000818:Animals; D001187:Artificial Organs; D001698:Biomedical Engineering; D004562:Electrocardiography; D006439:Hemodynamics / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D008297:Male; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D015656:Respiratory Mechanics; D012756:Sheep; D016278:Ventricular Function, Right / Q000502:physiology