title: Lipoma on the corpus callosum in a patient with schizophrenia-like episode: is there a causal relationship?
abstract: Disturbed interhemispheric communication has been proposed as responsible for schizophrenia. We present a case of a schizophrenia-like episode with no neurologic or other psychiatric symptoms. However, magnetic resonance imaging revealed a lipoma on the splenium of the corpus callosum. Neuropsychologic examination revealed normal interhemispheric transfer, but a slight dysfunction associated with right-hemispheric anterior regions. Rather than supporting the hypothesis of a causal relationship between callosal abnormality and schizophrenia-like symptoms, our findings argue against a direct causal relationship between lesion site and psychotic episode. We conclude that cerebral abnormality per se may represent a risk factor for neuropsychiatric symptoms.
authors.affiliation: Department of Neurology, University Hospital, Zurich, Switzerland. christian.baumann@usz.ch
authors.forename: Christian R
authors.initials: CR
authors.lastname: Baumann
authors.forename: Marianne
authors.initials: M
authors.lastname: Regard
authors.forename: Stephan
authors.initials: S
authors.lastname: Trier
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schuknecht
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Siegel
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology* / Q000523:psychology; D003337:Corpus Callosum / Q000473:pathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008067:Lipoma / Q000150:complications / Q000473:pathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000209:etiology*