title: [Wilson's principles--a base of modern teratology].
abstract: Wilson's principles were formulated after thalidomide tragedy. They become a fundamental for teratological studies with drugs and other factors that may disturb fetal development. It is postulated that susceptibility to teratogen depends on the genotype and developmental stage of the conceptus. Teratogenic agents act in specific manner on developing cells and tissues. The exposition depends on the agent's nature and availability. Manifestations of deviant development depends on the dosage and exposure frequency. In case of abnormal development the final manifestations include death of embryo or fetus, malformation, growth retardation and functional disorder.
authors.affiliation: Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka. fb3@wp.pl
authors.forename: Franciszek
authors.initials: F
authors.lastname: Burdan
authors.forename: Artur
authors.initials: A
authors.lastname: Bełzek
authors.forename: Justyna
authors.initials: J
authors.lastname: Szumiło
authors.forename: Jarosław
authors.initials: J
authors.lastname: Dudka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korobowicz
authors.forename: Edyta
authors.initials: E
authors.lastname: Tokarska
authors.forename: Lidia
authors.initials: L
authors.lastname: Klepacz
authors.forename: Marta
authors.initials: M
authors.lastname: Bełzek
authors.forename: Robert
authors.initials: R
authors.lastname: Klepacz
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005838:Genotype; D006801:Humans; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D011817:Rabbits; D051381:Rats; D013723:Teratogens / Q000633:toxicity*; D018600:Teratology / Q000639:trends*; D013997:Time Factors
chemical_list: D013723:Teratogens