[Functional polymorphism of manganese superoxide dismutase (MnSOD) gene correlates with schizophrenia in Polish population].
Neuro-developmental theory paid attention to an apoptosis role and reactive oxygen species (ROS) in schizophrenia pathogenesis. ROS concentration in cells is maintained on a low level due to manganese superoxide dismutase activity (MnSOD).


OBJECTIVE
An attempt of evaluation of Ala-9Val polymorphism in gene for MnSOD in schizophrenic patients and control group was undertaken.


METHODS
122 paranoid schizophrenia patients were asked to the study. Clinical evaluation were performed by using PANSS.


RESULTS
Alleles layout in control group (Val 45.95%) and an under-study group (Val 73.77%) was statistically different. Genotype layout also differentiated the groups. The under-study group: Ala/Ala--10.65%, Val/Ala--31.15%, Val/Val--58.2%; and in the control group respectivelly: 37.84%, 32.43%, 29.73%. relative risk for developing schizophrenia in people having in their polymorphism for MnSOD genotype Val-9Val is over three times (RR = 3.29) higher than for people not having this genotype. While evaluating correlations between a genotype, frequency of Ala-9Val allele polymorphism and social - demographic and clinical data of schizophrenic patients, no statistically substantial correlations were observed, even though there was a close to gravity correlation between a genotype Val-9Val and negative disease symptoms (p = 0.075).


CONCLUSIONS
1. In Polish populations there is a statistically substantial associations between schizophrenia incidence a genotype Val-9Val in gene for MnSOD. 2. The lack of association between selected social - demographic and clinical factors of schizophrenic patients and Ala-9Val polymorphism in a gene for MnSOD. 3. Risk for developing schizophrenia in people having Val-9Val genotype in a gene for MnSOD is over three times higher than for people not having this very genotype.
Gałecki
Piotr
P
Uniwersytet Medyczny w Lodzi, Klinika Psychiatrii i Zaburzeń Nerwicowych z Oddziałem Interwencji Kryzysowych. galeckipiotr@o2.pl
Pietras
Tadeusz
T
Szemraj
Janusz
J
Florkowska
Kinga
K
Florkowski
Antoni
A
Zboralski
Krzysztof
K
D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*
D013482:Superoxide Dismutase