title: Electroanalytical determination of paroxetine in pharmaceuticals.
abstract: Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at -1.55V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.
authors.affiliation: REQUIMTE, Instituto Superior de Engenharia do Porto, Rua Dr. António Bernardino de Almeida 431, 4200-072 Porto, Portugal.
authors.forename: Henri P A
authors.initials: HP
authors.lastname: Nouws
authors.forename: Cristina
authors.initials: C
authors.lastname: Delerue-Matos
authors.forename: Aquiles A
authors.initials: AA
authors.lastname: Barros
authors.forename: José A
authors.initials: JA
authors.lastname: Rodrigues
mesh_terms: D004563:Electrochemistry; D017022:Flow Injection Analysis; D017374:Paroxetine / Q000032:analysis*; D013607:Tablets
chemical_list: D013607:Tablets; D017374:Paroxetine