[Effect of chronic intramuscular administration of low molecular weight heparin-collagen complex on hemostatic indices and development of alloxan-induced diabetes].
Repeated intramuscular administration of low molecular weight heparin-collagen complex proved to increase fibrinolytic activity and to decrease platelet aggregation in the blood of rats (11 months) with depressed anticoagulant system. Administration of diabetogenic alloxan dose induced no diabetes mellitus in such animals.
Liapina
L A
LA
Ul'ianov
A M
AM
Pastorova
V E
VE
Obergan
T Iu
TIu
D000496:Alloxan / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D003094:Collagen / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced; D005342:Fibrinolysis / Q000187:drug effects*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D007273:Injections, Intramuscular; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D006495:Heparin, Low-Molecular-Weight; D000496:Alloxan; D003094:Collagen