AID and Igh switch region-Myc chromosomal translocations.
Chromosomal translocations involving Ig heavy chain switch regions and an oncogene, like Myc, represent early initiating events in the development of many B cell malignancies. These translocations are widely believed to result from aberrant class switch recombination (CSR). Recent reports have produced conflicting models for the role of activation-induced cytidine deaminase (AID) in this process. Here, we discuss possible roles of AID, CSR, and somatic hypermutation in generating chromosomal translocations and in tumor progression.
Unniraman
Shyam
S
Howard Hughes Medical Institute/Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Schatz
David G
DG
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D003564:Cytidine Deaminase / Q000235:genetics*; D004195:Disease Models, Animal; D050438:Genes, Immunoglobulin Heavy Chain; D016259:Genes, myc; D006801:Humans; D007134:Immunoglobulin Switch Region; D051379:Mice; D008807:Mice, Inbred BALB C; D010954:Plasmacytoma / Q000235:genetics*; D027041:Somatic Hypermutation, Immunoglobulin; D014178:Translocation, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase