The effects of inspiratory resistive training on respiratory muscle function in patients with muscular dystrophy.
The effects of inspiratory resistive training on respiratory muscle function was evaluated in 11 patients with Duchenne, limb-girdle, and facio-scapulo-humeral (FSH) type muscular dystrophy. Muscle training consisted of breathing against an inspiratory resistance for two 15-minute sessions each day while at home. Following 6 weeks of training, there were significant increases in the maximum resistance that could be tolerated for at least 5 minutes (P < 0.01) and also in the maximum duration that ventilations equal to 30%, 50%, 70%, and 90% of the maximum voluntary ventilation could be sustained (P < 0.05). In six patients who trained for an additional 6-week period, respiratory muscle endurance increased even further. The degree of improvement in respiratory muscle endurance was positively correlated with baseline vital capacity (r = 0.84, P < 0.05) and maximal inspiratory pressure (r = 0.76, P < 0.05). Spirometry, functional residual capacity, and maximal inspiratory and expiratory pressures were not affected by training. We conclude that inspiratory resistive training improves respiratory muscle endurance in muscular dystrophy patients. Improvement in respiratory muscle function may serve to delay the onset of respiratory complications in patients with muscular dystrophy.
DiMarco
A F
AF
Department of Medicine, Neurology and Pediatrics, Case Western Reserve University Cleveland, Ohio, USA.
Kelling
J S
JS
DiMarco
M S
MS
Jacobs
I
I
Shields
R
R
Altose
M D
MD
D000293:Adolescent; D000328:Adult; D001945:Breathing Exercises; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000502:physiology; D008875:Middle Aged; D009135:Muscular Diseases / Q000473:pathology* / Q000628:therapy*; D010807:Physical Endurance / Q000502:physiology; D012129:Respiratory Function Tests / Q000379:methods; D012132:Respiratory Muscles / Q000503:physiopathology*; D013997:Time Factors; D014797:Vital Capacity / Q000502:physiology