A choreography of nicotinic receptors directs the dopamine neuron routine.
Modulation of the mesocorticolimbic dopamine system by nicotinic acetylcholine receptors (nAChRs) is thought to play an important role in both health and addiction. However, a clear understanding of how these receptors regulate in vivo firing activity has been elusive. In this issue of Neuron, Mameli-Engvall and colleagues report an impressive and thought-provoking series of in vivo experiments combining single-unit recordings from dopamine neurons with nAChR subunit deletions and region-specific lentiviral subunit re-expression.
Ungless
Mark A
MA
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom. mark.ungless@csc.mrc.ac.uk
Cragg
Stephanie J
SJ
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology*
D011978:Receptors, Nicotinic; D004298:Dopamine