title: [Method of non-destructive mechanical testing of new surface coatings for prostheses].
abstract: Research into new surface coatings and surface processing methods for prostheses is subject to numerous studies. The aim of this study was to test an innovative biomechanical measuring method for the examination of the ingrowth of bone implants. Using a transcortical model, coated (n=14) or uncoated (n=14) titanic cylinders were implanted into the lateral condyle of 28 New Zealand White Rabbits. After 6 weeks or 6 months the animals were sacrificed and the osseointegration of the implants was evaluated biomechanically and histologically. Up to traction of 50 N the load dependent movement between bone and testing cylinder did not lead to a destruction of the bone-implant-interface. Therefore, biomechanical and histological investigations could be performed in the same specimen. The results of both evaluations showed a significant correlation (correlation coefficient -0.79; p < 0.01) and were absolutely reproducible. With the method of non-destructive mechanical testing, it is possible to halve the number of required animals. Additionally, the results of the biomechanical and histological analysis can be compared and thus serve as an internal control. In summary, the method of non-destructive mechanical testing represents an ideal tool to study new surface coatings and surface processing methods for prostheses.
authors.affiliation: Orthopädische Universitätsklinik Heidelberg, Deutschland.
authors.forename: Felix
authors.initials: F
authors.lastname: Zeifang
authors.forename: Jörg Heinrich
authors.initials: JH
authors.lastname: Holstein
authors.forename: Georgios
authors.initials: G
authors.lastname: Tosounidis
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Görtz
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Simank
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000295:instrumentation / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000032:analysis*; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000295:instrumentation* / Q000379:methods; D005269:Femur / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D006622:Hip Prosthesis; D066298:In Vitro Techniques; D008422:Materials Testing / Q000295:instrumentation* / Q000379:methods; D011817:Rabbits; D013718:Tensile Strength; D016474:Weight-Bearing
chemical_list: D020099:Coated Materials, Biocompatible