Family and twin studies in inflammatory bowel disease.
Studies examining the inheritance of inflammatory bowel disease (IBD) within different family groups have been the basis for recent molecular advances in the genetics of IBD. The derived heritability in Crohn's disease (CD) is higher than in many other complex diseases. The risk of IBD is highest in first-degree relatives of a CD proband, but first-degree relatives of a proband suffering from ulcerative colitis (UC) and more distant relatives are also at increased risk. Disease concordance rates in IBD have been examined in multiplex families and in three large European twin studies.
Halme
Leena
L
Department of Transplantation and Liver Surgery, Helsinki University Hospital, Finland. leena.halme@hus.fi
Paavola-Sakki
Paulina
P
Turunen
Ulla
U
Lappalainen
Maarit
M
Farkkila
Martti
M
Kontula
Kimmo
K
D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004200:Diseases in Twins / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors; D018433:Twin Studies as Topic