title: Catastrophic antiphospholipid syndrome and pulmonary embolism in a 3-year-old child.
abstract: We report a rare example of catastrophic antiphospholipid syndrome (CAPS) in a young child. A 3-year-old girl with no previous medical history presented with extensive and recurrent thromboses. The diagnosis of CAPS was based on the occurrence of cardiopulmonary embolism in the child with a high titre of autoantibodies directed against phospholipids and beta-2-glycoprotein 1. In spite of a relatively rapid diagnosis and multiple treatments, the outcome was unfavourable. Multimodality imaging, including both ultrasonography and spiral CT, allowed close follow-up of the thromboses.
authors.affiliation: Department of Radiology, University Hospital of Rouen, 1 Rue de Germont, Rouen, 76031, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Olivier
authors.forename: Eleonore
authors.initials: E
authors.lastname: Blondiaux
authors.forename: Thierry
authors.initials: T
authors.lastname: Blanc
authors.forename: Jeanne-Yvonne
authors.initials: JY
authors.lastname: Borg
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Dacher
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis*; D002388:Catastrophic Illness; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D013923:Thromboembolism / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy