Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis.
This study aims to evaluate the intestinal mucosal permeability in patients with acute pancreatitis. The lactulose:mannitol (L:M) ratio was used to assess permeability. It is an inexpensive and quite reliable method. The intestinal permeability was increased in patients with acute pancreatitis compared with the controls. In addition, patients with severe pancreatitis had higher intestinal barrier dysfunction compared with patients with mild pancreatitis, the L:M ratio being .2 and .029, respectively. It was also concluded that the permeability increased gradually over the course of pancreatitis and was maximum at day 7 (P < .01). This provides a window of opportunity for therapeutic intervention to prevent the late observed increase in intestinal permeability.
Nagpal
Kamal
K
kamnag76@yahoo.com
Minocha
Vivek Ratna
VR
Agrawal
Vivek
V
Kapur
Suman
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005765:Gastrointestinal Agents / Q000493:pharmacokinetics; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000493:pharmacokinetics*; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics*; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000378:metabolism*; D010539:Permeability; D011379:Prognosis; D012720:Severity of Illness Index; D013549:Sweetening Agents / Q000493:pharmacokinetics
D005765:Gastrointestinal Agents; D013549:Sweetening Agents; D008353:Mannitol; D007792:Lactulose