title: A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla.
abstract: A novel compound, rodgersinol (1), was isolated from the aerial parts of Rodgersia podophylla and its structure was elucidated with various spectroscopic methods. Rodgersinol (1) exhibited the significant inhibitory effects on iNOS and COX-2 expressions in LPS-activated macrophages.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Park
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seo
authors.forename: Kee-Dong
authors.initials: KD
authors.lastname: Yoon
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Ahn
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Sang Geon
authors.initials: SG
authors.lastname: Kim
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2