Combination therapies for deep venous thrombosis.
Nearly 1 million patients are treated for deep venous thrombosis annually in the United States, typically with anticoagulant therapy alone. While anticoagulation reduces risk for pulmonary embolism, up to two-thirds of patients experience some degree of postthrombotic syndrome. This review details the recent introduction of a variety of novel mechanical thrombectomy devices that, in combination with local delivery of thrombolytic agents, offers a new approach for rapid and effective removal of venous thrombus, while minimizing attendant risks of bleeding complications.
Kasirajan
Karthikeshwar
K
Division of Vascular Surgery and Endovascular Therapy, Emory University, Atlanta, GA 30322, USA. karthik_kasirajan@emoryhealthcare.org
Milner
Ross
R
Chaikof
Elliot L
EL
D002404:Catheterization / Q000009:adverse effects / Q000379:methods*; D002406:Catheterization, Peripheral / Q000295:instrumentation / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D004867:Equipment Design; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015337:Multicenter Studies as Topic; D011655:Pulmonary Embolism / Q000517:prevention & control; D014481:United States; D020246:Venous Thrombosis / Q000628:therapy*
D005343:Fibrinolytic Agents