Gelatinous transformation of bone marrow: a study of 43 cases.
Gelatinous marrow transformation (GMT) is an uncommon and poorly recognized condition characterized by deposition of seromucinous gelatinous material in the bone marrow stroma. Forty-three cases of GMT were studied in a period of 4 years. There was male preponderance. Fourteen cases were in pediatric age group (less than 12 years). Majority of patients had a preceding history of anorexia, malnutrition and chronic debility. All the patients had anemia. Bone marrow biopsy revealed focal or diffuse GMT. Bone marrow aspirate showed metachromatic dense mucoid material with a few entrapped hematopoietic cells on Giemsa staining. The gelatinous material stained with alcian blue at pH 2.5.
Jain
Rashmi
R
Department of Pathology, Maulana Azad Medical College, New Delhi. dr_rashmi_jain@yahoo.co.in
Singh
Zeba N
ZN
Khurana
Nita
N
Singh
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000855:Anorexia / Q000150:complications; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D001855:Bone Marrow Diseases / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005780:Gelatin; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007194:India; D007223:Infant; D008297:Male; D044342:Malnutrition / Q000150:complications; D008875:Middle Aged; D013194:Staining and Labeling
D005780:Gelatin; D006820:Hyaluronic Acid