Impaired sexual activity in male adults with partial androgen insensitivity.
BACKGROUND
Choosing the sex of rearing of an XY neonate with a major sexual ambiguity and a mutated androgen receptor remains one of the more difficult questions of neonatal endocrinology. A direct consequence of this choice is the accomplishment of sexual function in adulthood. There is very limited knowledge of the sexual performance of patients with partial androgen insensitivity syndrome.


OBJECTIVE
The objective of this study is to describe physical acts of sexuality in partial androgen insensitivity syndrome patients reared as males.


METHODS
We were able to obtain factual information regarding the sexual activity of 15 adult patients who had been reared as males and followed at our institution since birth. We evaluated their sexual performance using two validated questionnaires (Golombok-Rust Inventory of Sexual Satisfaction and International Index of Erectile Dysfunction).


RESULTS
We documented a major impairment of all parameters of sexual activity.


CONCLUSIONS
This long-term insight into the consequences of male sex assignment will have to be balanced by a study of the consequences of female sex assignment.
Bouvattier
Claire
C
Endocrinologie Pédiatrique, Groupe hospitalier Cochin-Saint Vincent de Paul, and Faculté Paris V, 82 av Denfert Rochereau, 75014 Paris, France.
Mignot
Brigitte
B
Lefèvre
Hervé
H
Morel
Yves
Y
Bougnères
Pierre
P
D000293:Adolescent; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000097:blood / Q000503:physiopathology*; D054304:Anti-Mullerian Hormone; D006023:Glycoproteins / Q000097:blood; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D008297:Male; D010413:Penis / Q000503:physiopathology; D012725:Sexual Behavior / Q000502:physiology* / Q000523:psychology; D011795:Surveys and Questionnaires; D013735:Testicular Hormones / Q000097:blood; D013739:Testosterone / Q000097:blood
D006023:Glycoproteins; D006062:Gonadotropins; D013735:Testicular Hormones; C422364:inhibin B; D013739:Testosterone; D007265:Inhibins; D054304:Anti-Mullerian Hormone