title: 1'S-1'-acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport.
abstract: AIDS remains a major global health concern. Despite a number of therapeutic advancements, there is still an urgent need to develop a new class of therapy for human immunodeficiency virus (HIV). Here, it was shown that 1'S-1'-acetoxychavicol acetate (ACA), a small molecular compound isolated from the rhizomes of Alpinia galanga, inhibited Rev transport at a low concentration by binding to chromosomal region maintenance 1 and accumulating full-length HIV-1 RNA in the nucleus, resulting in a block in HIV-1 replication in peripheral blood mononuclear cells. Additionally, ACA and didanosine acted synergistically to inhibit HIV-1 replication. Thus, ACA may represent a novel treatment for HIV-1 infection, especially in combination with other anti-HIV drugs.
authors.affiliation: Department of Biomedical Sciences and the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China.|Department of Research and Development, Nanchang Helioeast Science and Technology Co. Ltd, Nanchang, Jiangxi 330096, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Biomedical Sciences and the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China.
authors.forename: Baoan
authors.initials: B
authors.lastname: Li
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D032429:Alpinia / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001483:Base Sequence; D001592:Benzyl Alcohols; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D015694:Gene Products, rev / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000821:virology; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D054321:rev Gene Products, Human Immunodeficiency Virus
chemical_list: D019380:Anti-HIV Agents; D001592:Benzyl Alcohols; D015694:Gene Products, rev; D010936:Plant Extracts; D012367:RNA, Viral; D013729:Terpenes; D054321:rev Gene Products, Human Immunodeficiency Virus; C047948:1'-acetoxychavicol acetate