title: Rate of pathologic complete responses to docetaxel, cisplatin, and fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck.
abstract: OBJECTIVE
  To report the rate of pathological complete response after induction chemotherapy with the docetaxel, cisplatin, and fluorouracil (TPF) combination.
  
  
  METHODS
  Retrospective cohort analysis.
  
  
  METHODS
  Tertiary care academic cancer center, between June 1999 and May 2004.
  
  
  METHODS
  Seventy-two patients with newly diagnosed squamous cell carcinoma of the head and neck; 68 (95%) of the patients had stage IV, locally advanced disease.
  
  
  METHODS
  Three cycles of induction chemotherapy followed by a biopsy of the primary site. All patients subsequently underwent chemotherapy with 3 cycles of TPF.
  
  
  METHODS
  Rate of pathological complete response at the primary site after induction chemotherapy with 3 cycles of TPF.
  
  
  RESULTS
  Biopsy results were negative for cancer in 64 patients (89%) and positive in 8 patients (11%). The median follow-up was 2 years. In the positive biopsy result group, 2 (25%) of 8 patients died of disease vs 3 (4%) of 64 patients in the negative biopsy result group. Twenty-nine neck dissections were performed; results were positive in 7 patients (all alive with no evidence of disease) and negative in 22 patients (21 alive with no evidence of disease). The overall 2- and 5-year progression-free survival is currently projected at 85% and 85%, respectively; the overall 2- and 5-year survival, at 95% and 90%, respectively. Importantly, T4 presentation did not predict a positive biopsy result at the primary site or a positive neck dissection result (P = .60 and P = .56, respectively). N3 presentation (12 patients) did not predict a positive biopsy result at the primary site (P = .87) but did correlate with positive neck dissection results in 6 of 12 patients (P<.001).
  
  
  CONCLUSIONS
  Induction chemotherapy with the TPF regimen results in a high pathological complete response rate (89%). This rate is higher than with the cisplatin plus fluorouracil combination therapy, which was reported to be between 25% and 50% in previous studies. Chemoradiotherapy is currently an accepted standard of care, but induction chemotherapy continues to be investigated. Based on recent phase 3 trial results and the data presented herein, we propose that the 3-drug combination be used as the new platform when administering induction chemotherapy.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass, USA. Robert_haddad@dfci.harvard.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Haddad
authors.forename: Roy
authors.initials: R
authors.lastname: Tishler
authors.forename: Lori
authors.initials: L
authors.lastname: Wirth
authors.forename: Charles M
authors.initials: CM
authors.lastname: Norris
authors.forename: Laura
authors.initials: L
authors.lastname: Goguen
authors.forename: Christopher
authors.initials: C
authors.lastname: Sullivan
authors.forename: Lindsay
authors.initials: L
authors.lastname: O'Donnell
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Marshall
authors.initials: M
authors.lastname: Posner
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil