Manoalide derivatives from a sponge, Luffariella sp.
A new derivative of manoalide, 24-n-propyl-O-manoalide (1) together with manoalide (4) and four known derivatives (2, 3, 5, 6) were isolated from the methanolic extract of a sponge. Their structures were elucidated on the basis of spectroscopic method. All the compounds showed significant cytotoxicity against HCT-116 cell line by MTS assay. Secomanoalide indicated antifungal activity on fungal lines Candida glabrata,Candida krusei and Candida albicans by invitro antibiotic assay.
Zhou
Guang-Xiong
GX
College of Pharmacy, Jinan University, Guangzhou 510632, China. guangxzh@sina.com
Molinski
Tadeusz F
TF
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D002175:Candida / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D013729:Terpenes; C045673:manoalide