title: [Influences of excess iodine on thyroid hormone concentrations in cerebrum of filial mice and intervention of selenium].
abstract: OBJECTIVE
  To study the influence of excessive iodine intake on thyroid hormones in cerebrum of filial mice and intervention of selenium.
  
  
  METHODS
  60 Balb/c mice were divided randomly into 4 groups: control group, iodine group, selenium group and iodine plus selenium group and given tap water, tap water containing iodine 3000 microg/L, tap water containing selenium 200 microg/L and tap water containing iodine plus selenium 200 microg/L respectively as drinking water. At the end of the fourth month, the mice mated. Thyroid hormones and TSH in serum and in cerebrum of filial mice were determined at the postnatal 0, 14th and 28th day.
  
  
  RESULTS
  At the postnatal 14th day, serum TT4 level was lower significantly, and serum TSH was higher in iodine group than those in control group and in the iodine plus selenium group. At the postnatal 0 day and 14th day, thyroid hormone concentrations in the cerebrum of progeny of mice were lower significantly in iodine group than those in control group, selenium group and iodine plus selenium (P < 0.05). No significant difference was observed among the four groups in TT4, TT3 and rT3 concentrations in serum and cerebrum at the postnatal 28th day.
  
  
  CONCLUSIONS
  Excessive iodine intake can change thyroid hormone concentrations in the cerebrum of progeny of mice and selenium supplementation exerted favorable effects on it.
authors.affiliation: Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Huai-lan
authors.initials: HL
authors.lastname: Guo
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Hou
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D054022:Cerebrum / Q000378:metabolism*; D005260:Female; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D012643:Selenium / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000378:metabolism*; D013970:Thyronines / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D014284:Triiodothyronine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D013970:Thyronines; D014284:Triiodothyronine; C040407:3,3',5-triiodothyronamine; D013972:Thyrotropin; D007455:Iodine; D012643:Selenium