The effect of T cell independent and cross-reactive antigen on the immune response to pneumococcal conjugate vaccination.
The effect of priming with various antigens on subsequent vaccination with the pneumococcal conjugate vaccine (CPV) was determined using BALB/c mice. Priming with pneumococcal polysaccharide or cross-reactive polysaccharide did not inhibit the IgG response to CPV immunization. Additionally, live intranasal colonization by Streptococcus pneumoniae or cross-reactive organism resulted in higher IgG responses to CPV. These results suggest that colonization elicits immunological memory capable of boosting the immune response to CPV.
Rabquer
Bradley
B
Department of Medicine, Medical University of Ohio, Toledo, OH 3614, United States.
Smithson
S Louise
SL
Shriner
Anne
A
Julie Westerink
M A
MA
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D018928:Immunity, Mucosal / Q000276:immunology; D007117:Immunization, Secondary / Q000379:methods; D007074:Immunoglobulin G / Q000276:immunology*; D007156:Immunologic Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D009296:Nasal Cavity / Q000276:immunology / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000254:growth & development / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000379:methods; D018074:Vaccines, Conjugate / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate