Deletion polymorphisms in the promoter region of Fcgamma receptor IIB is not associated with antigen-specific IgG2a and IgG2b antibody responses in NC/Nga mice.
Fcgamma receptor (R) IIB, a low-affinity FcR for IgG, inhibits B cell Ag R (BCR)-mediated activation when these two receptors are cross-linked by Ag and IgG-containing immune complexs (ICs). We found deletion polymorphisms in the promoter region of fcgr2b in NC/Nga mice, a model for human atopic dermatitis. NC/Nga mice produced significantly higher levels of ovalbumin (OVA)-specific IgG, IgG2a and IgG2b than did BALB/c mice. Analysis of (BALB/c x NC/Nga)F1 x BALB/c or (BALB/c x NC/Nga) F1 x NC/Nga backcross mice revealed that deletion polymorphisms of fcgr2b in NC/Nga mice does not directly regulate hyper OVA-specific IgG2a and IgG2b Ab responses.
Sakai
Tohru
T
Department of International Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tohrus@nutr.med.tokushima-u.ac.jp
Kogiso
Mari
M
Mitsuya
Kaori
K
Komatsu
Tatsushi
T
Yamamoto
Shigeru
S
D000818:Animals; D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology*; D005260:Female; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017452:Receptors, IgG / Q000235:genetics*
D007074:Immunoglobulin G; D017452:Receptors, IgG; D010047:Ovalbumin