title: Negative pressure wound therapy to treat hematomas and surgical incisions following high-energy trauma.
abstract: OBJECTIVE
  To evaluate the use of negative pressure wound therapy (NPWT) to augment healing of surgical incisions and hematomas after high-energy trauma.
  
  
  METHODS
  This study is a prospective randomized evaluation of NPWT in trauma patients, randomizing patients with draining hematomas to either a pressure dressing (group A) or a VAC (group B). Additionally, patients with calcaneus, pilon, and high-energy tibial plateau fractures were randomized to either a standard postoperative dressing or a VAC over the sutures.
  
  
  RESULTS
  There were 44 patients randomized into the hematoma study. Group A drained a mean of 3.1 days, compared with only 1.6 days for group B. This difference was significant (p=0.03). The infection rate for group A was 16%, compared with 8% in group B. An additional 44 patients have been randomized into the fracture study. Again, a significant difference (p=0.02) was present when comparing drainage in group A (4.8 days) and group B (1.8 days). No significant difference was present at current enrollment for infection or wound breakdown.
  
  
  CONCLUSIONS
  NPWT has been used on many complex traumatic wounds. Potential mechanisms of action include angiogenesis, increased blood flow, and decreased interstitial fluid. This ongoing randomized study has demonstrated decreased drainage and improved wound healing following both hematomas and severe fractures.
authors.affiliation: Department of Surgery, Orthopaedic Division, University of Alabama at Birmingham, Birmingham, Alabama 35294-3295, USA. James.Stannard@ortho.uab.edu
authors.forename: James P
authors.initials: JP
authors.lastname: Stannard
authors.forename: James T
authors.initials: JT
authors.lastname: Robinson
authors.forename: E Ratcliffe
authors.initials: ER
authors.lastname: Anderson
authors.forename: Gerald
authors.initials: G
authors.lastname: McGwin
authors.forename: David A
authors.initials: DA
authors.lastname: Volgas
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Alonso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D004322:Drainage; D005260:Female; D050723:Fractures, Bone / Q000601:surgery*; D006406:Hematoma / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011446:Prospective Studies; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014618:Vacuum; D014945:Wound Healing