Prothrombotic risk factors in ischemic stroke and migraine in children.
OBJECTIVE
To evaluate the contribution of antiphospholipid antibodies (aPL) and thrombomodulin (Thm) in the pathogenesis of stroke and migraine in children.


METHODS
Ninety children were included in the study: 30 children (4-15 years) after an ischemic stroke of an unknown etiology; 30 migrainous patients (8-15 years), who were hospitalized in the Department of Developmental Neurology, Medical University of Gdansk, Poland, and 30 healthy children of the same age.


RESULTS
The statistical analysis showed an increase in the values of anticardiolipin antibodies (aCL), anti beta2-glycoprotein 1 (beta2-GP1) and Thm in children with stroke and migraine than in the control group. The resultant values were higher, but stayed at standard.


CONCLUSIONS
The possible role of prothrombotic factors in individual cases of pediatric stroke and migraine cannot be excluded.
Pilarska
E
E
Department of Developmental Neurology, Medical University of Gdansk, Gdansk, Poland. pilar@amg.gda.pl
Lemka
M
M
Bakowska
A
A
D000293:Adolescent; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000032:analysis / Q000097:blood*; D001777:Blood Coagulation / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D015984:Causality; D002536:Cerebral Arteries / Q000378:metabolism / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008881:Migraine Disorders / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D018180:Thrombomodulin / Q000032:analysis / Q000097:blood*; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D018180:Thrombomodulin; D053482:beta 2-Glycoprotein I