title: A case of breast cancer metastatic to the tail of the pancreas.
abstract: Breast cancer metastasis to pancreas is rarely seen. There have been only 6 cases described in the literature. We present the seventh case of a 54-year-old woman with breast cancer that metastasized to the tail of the pancreas 4 years and 4 months after radical mastectomy. Although the serum levels of CA15-3 and TPA had gradually increased without symptoms, it was difficult to establish the diagnosis before contrast-enhanced abdominal CT scan was performed. Immunohistochemical staining using E-cadherin was positive, proving that the breast cancer was ductal rather than lobular in origin. CA15-3 immunohistochemically stained positive in the resected pancreas lesion. Positive monoclonal staining by GCDFP-15 (gross cystic disease fluid protein-15) in the pancreas tumor also confirmed it breast cancer origin. Investigation of chemokine/chemokine receptors may clarify a new mechanism of metastasis to the pancreas from breast cancer.
authors.affiliation: Department of Surgery, Funabashi Municipal Medical Center, Chiba, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tohnosu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Narushima
authors.forename: Keita
authors.initials: K
authors.lastname: Sunouchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saito
authors.forename: Takanori
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hajime
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Maruyama
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Taku
authors.initials: T
authors.lastname: Kato
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Shimizu
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Uehara
authors.forename: Satoru
authors.initials: S
authors.lastname: Ishii
mesh_terms: D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000628:therapy; D018570:Risk Assessment; D016896:Treatment Outcome