[Current knowledge on aquaporin water channels: clinical implications].
The discovery of the aquaporin family of water channels has explained to a high degree the mechanism of water transport across cell membranes. The molecular structure of the first purified aquaporin shows its tetrameric organization with each subunit containing an individual aqueous pore selectively permeable for water but not for protons. At least 11 human aquaporins have been identified. Definition of sites of their expression enabled explanation of their physiological role as well as pathological importance in congenital cataract or nephrogenic diabetes insipidus.
Jasiewicz
Małgorzata
M
Department of Endocrinology, Diabetes and Internal Medicine, Medical University, Białystok.
Myśliwiec
Janusz
J
D000818:Animals; D020346:Aquaporins / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D018500:Diabetes Insipidus, Nephrogenic / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism / Q000503:physiopathology*; D011487:Protein Conformation; D014867:Water / Q000378:metabolism*
D020346:Aquaporins; D014867:Water