title: Clinical impact of concomitant surgical diagnosis and subsequent lobectomy for preoperatively undiagnosed lung cancer.
abstract: OBJECTIVE
  We conducted a retrospective study of the clinical impact of a concomitant diagnostic and therapeutic procedure for patients with histologically unproven pulmonary nodules.
  
  
  METHODS
  Between January 2001 and December 2003, we performed 150 consecutive surgical biopsy procedures for histologically indeterminate pulmonary nodules. We compared the clinical impact of the concomitant diagnostic wedge resection followed by lobectomy (U group, n=50) with that of a scheduled standard lobectomy in those with preoperatively proven clinical stage I lung cancer during the same period (C group, n=60).
  
  
  RESULTS
  There were no significant differences in dichotomous variables, whereas we found significant differences in tumor size, operative time and blood loss between the 2 groups. Complication developed in 9 in the U group and 3 in the C group (p=0.030). Hospital mortality was 2% in the U group and 0% in the C group (p=0.11).
  
  
  CONCLUSIONS
  Morbidity and mortality following a concomitant diagnostic and therapeutic procedure in patients with preoperatively undiagnosed lung cancer was acceptable, however, staged operations should be indicated for patients with considerable co-morbidity.
authors.affiliation: Department of General Thoracic Surgery, Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Masaru
authors.initials: M
authors.lastname: Koma
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kadota
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Funakoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusu
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
mesh_terms: D003949:Diagnostic Techniques, Surgical; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy