title: Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome.
abstract: We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Banha, Banha, Egypt.
authors.forename: M K
authors.initials: MK
authors.lastname: Rizk
authors.forename: A
authors.initials: A
authors.lastname: El-Nawawy
authors.forename: E
authors.initials: E
authors.lastname: Abdel-Kareem
authors.forename: E S
authors.initials: ES
authors.lastname: Amer
authors.forename: D
authors.initials: D
authors.lastname: El-Gezairy
authors.forename: A Z
authors.initials: AZ
authors.lastname: El-Shafei
mesh_terms: D000704:Analysis of Variance; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006776:Hospitals, Pediatric; D006785:Hospitals, University; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D011237:Predictive Value of Tests; D012008:Recurrence; D012074:Remission Induction; D012709:Serum Albumin / Q000378:metabolism; D016896:Treatment Outcome; D048069:Tumor Necrosis Factors / Q000097:blood* / Q000276:immunology; D001613:beta 2-Microglobulin / Q000276:immunology / Q000652:urine*
chemical_list: D006454:Hemoglobins; D007375:Interleukin-1; D015850:Interleukin-6; D012709:Serum Albumin; D048069:Tumor Necrosis Factors; D001613:beta 2-Microglobulin