title: Trends in HIV testing, serial HIV prevalence and HIV incidence among people attending a Center for AIDS Prevention from 1988 to 2003.
abstract: OBJECTIVE
  To analyse trends in HIV testing, serial HIV prevalence and HIV incidence among people who underwent voluntary testing in a Center for AIDS Prevention in Valencia, Spain.
  
  
  METHODS
  Open cohort study including all subjects who went to the Center for AIDS Prevention from 1988 to 2003. Information on sociodemographic variables and HIV test results was collected. Serial prevalence and incidence rates were calculated, and joinpoint regression was used to identify changes in trends over time.
  
  
  RESULTS
  21,241 subjects were analysed; 67% men, 27% injecting drug users (IDUs), 43% heterosexuals and 13% men who have sex with men (MSM). From 1988 to 1990, IDUs accounted for 57% of clinic attenders, decreasing to 14% by 1997-2003, accompanied by an increase in heterosexuals. Overall, HIV prevalence for the whole period was 15%, dropping from 35% to <10% after 1999 and to 3% by 2003, when HIV prevalence was 26% in IDUs, 6% in MSM and 2% in heterosexuals. Total HIV incidence was 2.5%. From 1988 to 1990, HIV incidence ranged from 6% to 8%, and a gradual and progressive decline observed from 1990 onwards. From 1995 onwards, HIV incidence was <2%. The highest incidence rate is seen in IDUs, 7-12% in the first period and 4-5% at the end. Among MSM, a change in the decreasing trend is seen by 1998, and increases in incidence are detected by 2002-3.
  
  
  CONCLUSIONS
  Serial HIV prevalence has markedly decreased from 1988 in all transmission categories, although it is still high. With regard to HIV incidence, the drop has been marked too, although a worrying increase, that requires further follow-up, has been detected in MSM in the past 2 years.
authors.affiliation: Unitat d'Epidemiologia i Estadística, Escola Valenciana d'Estudis en Salut (EVES), C/Juan de Garay 21, 46017 Valencia, Spain. hurtado_isa@gva.es
authors.forename: I
authors.initials: I
authors.lastname: Hurtado
authors.forename: I
authors.initials: I
authors.lastname: Alastrue
authors.forename: I
authors.initials: I
authors.lastname: Ferreros
authors.forename: J
authors.initials: J
authors.lastname: del Amo
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: T
authors.initials: T
authors.lastname: Tasa
authors.forename: I
authors.initials: I
authors.lastname: Hernández-Aguado
authors.forename: S
authors.initials: S
authors.lastname: Pérez-Hoyos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D020010:Heterosexuality / Q000706:statistics & numerical data; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D013030:Spain / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D013997:Time Factors