The Bax pore in liposomes, Biophysics.
The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.
Schlesinger
P H
PH
Department of Physiology and Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saito
M
M
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D048069:Tumor Necrosis Factors / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*
D008081:Liposomes; D048069:Tumor Necrosis Factors; D051028:bcl-2-Associated X Protein