title: [Relative renal function based on DMSA uptake corrected for volume: normalized relative renal function].
abstract: OBJECTIVE
  Relative renal function (RRF) quantification based on dimercaptosuccinic acid (DMSA) uptake is an established method for determining differential renal function. An abnormal kidney size may lead to an alteration in its RRF value, although it has no dysfunction. Therefore, it is useful to correct RRF values taking into account relative renal volumes, thus obtaining the normalized relative renal function (NRRF). The feasibility of the method used for volume correction, differences with respect to usual quantification and different normality intervals were studied.
  
  
  METHODS
  A total of 187 DMSA renal scintigraphies (130 children and 57 adults) were studied. RRF was quantified and volume corrected to obtain NRRF. Patients were classified as normal or pathological using various normality intervals for NRRF. A second classification was performed depending on how the diagnostic changed after volume correction.
  
  
  RESULTS
  An increase of pathological diagnosis was observed after volume correction, mainly in children. Using an intermediate estimation for the normality interval, 53% of the initially pathological diagnosis for children may be caused simply by different renal volumes.
  
  
  CONCLUSIONS
  NRRF provides complementary information to RRF and helps to distinguish between a smaller kidney and a really hypofunctioning one in cases with abnormal RRF.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario La Fe, Valencia, España. marti_jfr@gva.es
authors.forename: J
authors.initials: J
authors.lastname: Gimeno Olmos
authors.forename: J F
authors.initials: JF
authors.lastname: Martí Vidal
authors.forename: P
authors.initials: P
authors.lastname: Bello Arqués
authors.forename: I
authors.initials: I
authors.lastname: Hervás Benito
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres Tárrega
authors.forename: A
authors.initials: A
authors.lastname: Mateo Navarro
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012016:Reference Values; D012737:Sex Factors; D004113:Succimer / Q000493:pharmacokinetics
chemical_list: D004113:Succimer