Catastrophic antiphospholipid syndrome and pulmonary embolism in a 3-year-old child.
We report a rare example of catastrophic antiphospholipid syndrome (CAPS) in a young child. A 3-year-old girl with no previous medical history presented with extensive and recurrent thromboses. The diagnosis of CAPS was based on the occurrence of cardiopulmonary embolism in the child with a high titre of autoantibodies directed against phospholipids and beta-2-glycoprotein 1. In spite of a relatively rapid diagnosis and multiple treatments, the outcome was unfavourable. Multimodality imaging, including both ultrasonography and spiral CT, allowed close follow-up of the thromboses.
Olivier
Carine
C
Department of Radiology, University Hospital of Rouen, 1 Rue de Germont, Rouen, 76031, France.
Blondiaux
Eleonore
E
Blanc
Thierry
T
Borg
Jeanne-Yvonne
JY
Dacher
Jean-Nicolas
JN
D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis*; D002388:Catastrophic Illness; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D013923:Thromboembolism / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy