title: Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment.
abstract: The authors have characterized frontal cortical tau protein in cognitively intact (4) and cognitively impaired (ALSci, 4) ALS patients and compared it with control (2) or Alzheimer disease (AD, 1)- derived tau. The authors observed expression of both 3R and 4R tau isoforms; increased insoluble tau protein; phosphatase resistance; and hyperphosphorylation at T175, S208, and S210. Soluble tau from both AD and ALSci was also phosphorylated at S237. Tau hyperphosphorylation is associated with ALS.
authors.affiliation: Cell Biology Research Group, Robart's Research Institute, London, Ontario, Canada. mstrong@uwo.ca
authors.forename: M J
authors.initials: MJ
authors.lastname: Strong
authors.forename: W
authors.initials: W
authors.lastname: Yang
authors.forename: W L
authors.initials: WL
authors.lastname: Strong
authors.forename: C
authors.initials: C
authors.lastname: Leystra-Lantz
authors.forename: H
authors.initials: H
authors.lastname: Jaffe
authors.forename: H C
authors.initials: HC
authors.lastname: Pant
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D016875:tau Proteins / Q000032:analysis* / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D016875:tau Proteins