Successful recovery of acute hemosiderotic heart failure in beta-thalassemia major treated with a combined regimen of desferrioxamine and deferiprone.
We report the case of a 25-years-old male with beta-thalassemia major who developed acute heart failure, with severe systolic dysfunction, resulting from iron overload. Combined iron chelation with desferrioxamine and deferiprone together with standard cardiological treatment induced prompt and complete restoration of the cardiac function.
Tavecchia
Luisa
L
Gruppo Operativo di Cura delle Anemie Congenite, OspedaleSan Gerardo, Monza, Italy. luisatave@virgilio.it
Masera
Nicoletta
N
Russo
Pierluigi
P
Cirò
Antonio
A
Vincenzi
Antonella
A
Vimercati
Chiara
C
Masera
Giuseppe
G
D000328:Adult; D000077543:Deferiprone; D003676:Deferoxamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000209:etiology*; D006486:Hemosiderosis / Q000150:complications*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D011728:Pyridones / Q000627:therapeutic use*; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000150:complications / Q000188:drug therapy*
D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D003676:Deferoxamine