Effect of cell culture conditions on the anticytomegalovirus activity of maribavir.
The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.
Chou
Sunwen
S
Medical and Research Services, VA Medical Center and Oregon Health & Scince University, Portland, OR 97239, USA. chous@ohsu.edu
Van Wechel
Laura C
LC
Marousek
Gail I
GI
D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development*; D005347:Fibroblasts / Q000821:virology; D017930:Genes, Reporter; D006801:Humans; D008168:Lung / Q000166:cytology / Q000821:virology; D012263:Ribonucleosides / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000821:virology; D014776:Virus Cultivation / Q000379:methods; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
D000469:Alkaline Phosphatase; D000998:Antiviral Agents; D001562:Benzimidazoles; D012263:Ribonucleosides; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole