[Clinical significance of antineutrophil cytoplasmic antibodies in patients with lupus nephritis].
OBJECTIVE
To analyze the clinical features of patients with lupus nephritis positive for antineutrophil cytoplasmic antibodies (ANCA) and explore the clinical implications of ANCA detection.


METHODS
Totally 261 patients with lupus nephritis were enrolled in this study, including 53 ANCA-positive and 208 ANCA-negative ones. The clinical data of the patients pertaining to the disease history, physical examination, laboratory examinations and pathological inspection were retrospectively analyzed.


RESULTS
Compared with patients negative for ANCA, the ANCA-positive patients had significantly higher incidence of serositis (75.5%), acute renal failure (64.2%), myocarditis (30.2%), neuropsychiatric involvement (26.4%) and lung hemorrhage (7.5%)(P<0.05). Significant differences were also found between the two groups in SLE disease active index (SLE-DAI), number of the diagnostic criteria, erythrocyte sedimentation rate (ESR), anemia, anti-Sm antibodies, and serum complement C(3). Most patients positive for ANCA (67.9%) had type IV lupus nephritis with more crescent formation, renal tubular atrophy, hyaline thrombi, and higher mortality rate as well than the negative patients.


CONCLUSIONS
ANCA detection may benefit the estimation of the disease severity and prognostic evaluation of lupus nephritis.
Yu
Yong-wu
YW
Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yuywu@126.com
Liu
Zheng-rong
ZR
Xie
Di
D
Chen
Sheng-xiao
SX
Li
Hong-yan
HY
D000293:Adolescent; D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000097:blood; D008181:Lupus Nephritis / Q000276:immunology* / Q000473:pathology; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies
D019268:Antibodies, Antineutrophil Cytoplasmic; D007155:Immunologic Factors