title: Novel peroxidase mimics: mu-Aqua manganese-Schiff base dimers.
abstract: The interaction of manganese(II) carboxylate salts [Mn(O(2)CR)(2), where R=ethane, pentane] with H(2)L(1) [N,N'-bis(3-methoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] and H(2)L(2) [N,N'-bis(3-ethoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] was studied. MnL(1)(O(2)CEt)(H(2)O) (1), MnL(1)(O(2)CPe(n))(H(2)O) (2), MnL(2)(O(2)CEt)(H(2)O)(2) (3) and MnL(2)(O(2)CPe(n))(H(2)O)(2) (4) were isolated and thoroughly characterised by elemental analysis, FAB mass spectrometry, infrared and (1)H NMR spectroscopy, magnetic susceptibility measurements, molar conductivities, and cyclic and normal pulse voltammetry. Compounds 1 and 2 were crystallographically characterised revealing a tetragonally elongated octahedral geometry for the manganese coordination sphere and also a dimeric nature through mu-aqua bridges. Complexes 1-4 behave as efficient peroxidase mimics in the presence of the water-soluble trap ABTS, probably due to their ease to coordinate the substrate molecule. A correlation between rhombicity of the complexes and peroxidase activity has also been established.
authors.affiliation: Departamento de Química Inorgánica, Facultade de Química, Universidade de Santiago de Compostela, Avda. das Ciencias, s/n, Santiago de Compostela, Galicia E-15782, Spain. qimb45@usc.es
authors.forename: Manuel R
authors.initials: MR
authors.lastname: Bermejo
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Fernández
authors.forename: Ana M
authors.initials: AM
authors.lastname: González-Noya
authors.forename: Marcelino
authors.initials: M
authors.lastname: Maneiro
authors.forename: Rosa
authors.initials: R
authors.lastname: Pedrido
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Rodríguez
authors.forename: Juan C
authors.initials: JC
authors.lastname: García-Monteagudo
authors.forename: Bruno
authors.initials: B
authors.lastname: Donnadieu
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D019281:Dimerization; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D017895:Manganese Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009195:Peroxidase / Q000737:chemistry*; D010655:Phenylenediamines / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D017895:Manganese Compounds; D010655:Phenylenediamines; D012545:Schiff Bases; D009195:Peroxidase