title: Cellular responses to DNA damage: one signal, multiple choices.
abstract: DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.
authors.affiliation: Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. Tin.su@colorado.edu
authors.forename: Tin Tin
authors.initials: TT
authors.lastname: Su
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D016615:Telomere / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins