title: Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats.
abstract: In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
authors.affiliation: Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen, France.
authors.forename: Rachel
authors.initials: R
authors.lastname: Marion
authors.forename: Asiya
authors.initials: A
authors.lastname: Baishanbo
authors.forename: Gilles
authors.initials: G
authors.lastname: Gargala
authors.forename: Arnaud
authors.initials: A
authors.lastname: François
authors.forename: Philippe
authors.initials: P
authors.lastname: Ducrotté
authors.forename: Celia
authors.initials: C
authors.lastname: Duclos
authors.forename: Jean
authors.initials: J
authors.lastname: Fioramonti
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Ballet
authors.forename: Loïc
authors.initials: L
authors.lastname: Favennec
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003457:Cryptosporidiosis / Q000276:immunology* / Q000503:physiopathology; D016785:Cryptosporidium parvum; D005260:Female; D006967:Hypersensitivity / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D007583:Jejunum / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley