Vasopressin treatment for cyclic antidepressant overdose.
Due to neurotransmitter reuptake inhibition, peripheral alpha receptor blocking effects, and sodium channel blockade, severe cyclic antidepressant poisoning may lead to intractable hypotension. We report a case of severe amitriptyline toxicity, with hypotension unresponsive to direct alpha receptor agonists after pH manipulation, but improved with intravenous vasopressin. Vasopressin use in the setting of cyclic antidepressant toxicity has not been previously reported. Vasopressin may be a beneficial agent in the treatment of recalcitrant hypotension associated with poisoning or overdose. The anecdotal nature of this report must be emphasized and the use of vasopressin requires further research to define efficacy, dose, and potential side effects.
Barry
James David
JD
Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA.
Durkovich
David W
DW
Williams
Saralyn R
SR
D000639:Amitriptyline / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D062787:Drug Overdose / Q000188:drug therapy*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014667:Vasopressins / Q000627:therapeutic use*
D000929:Antidepressive Agents, Tricyclic; D014662:Vasoconstrictor Agents; D014667:Vasopressins; D000639:Amitriptyline