title: Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study.
abstract: Inflammation plays a role in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events. Furthermore, CRP has been claimed to play a role in the pathogenesis of atherosclerosis; therefore, CRP polymorphisms might be associated with acute myocardial infarction (AMI). We have analyzed male patients affected by AMI and healthy age-related male controls from Sicily for +1059G/C CRP single-nucleotide polymorphism (SNP). There was a significantly higher frequency of +1059C SNP (P = 0.0008; OR 3.86) in patients compared to controls. CRP serum levels were significantly higher in C+ healthy subjects rather than in C- subjects (P = 0.0075). The results of the present pilot case-control study performed in a homogeneous caucasoid population suggest that +1059C CRP gene SNP is associated with AMI. In any case, the results of the present study should add to the growing body of evidence on the role of pro-inflammatory genotypes in unsuccessful aging, determining susceptibility to immune-inflammatory diseases such as coronary heart disease.
authors.affiliation: Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università degli studi di Palermo, Italy.
authors.forename: Carmela Rita
authors.initials: CR
authors.lastname: Balistreri
authors.forename: Sonya
authors.initials: S
authors.lastname: Vasto
authors.forename: Florinda
authors.initials: F
authors.lastname: Listì
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Grimaldi
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Colonna-Romano
authors.forename: Marco
authors.initials: M
authors.lastname: Caruso
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.forename: Enrico
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
mesh_terms: D000208:Acute Disease / Q000453:epidemiology; D000328:Adult; D002097:C-Reactive Protein / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005787:Gene Frequency; D006801:Humans; D007125:Immunogenetics; D007249:Inflammation / Q000097:blood / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012802:Sicily / Q000453:epidemiology
chemical_list: D002097:C-Reactive Protein