Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study.
Creutzfeldt-Jakob disease (CJD) can occasionally present with a clinical picture resembling a corticobasal degeneration (CBD). Transcallosal inhibition, as tested by focal transcranial magnetic stimulation, is frequently absent or highly disrupted in CBD patients. We report a case of CJD presenting at the beginning of the disease as a CBD in which the ipsilateral silent period (iSP) was present and well detectable. This brief report shows that study of the iSP may be a useful diagnostic tool in order to differentiate CBD from syndromes presenting with similar clinical features.
Avanzino
L
L
Department of Neurosciences, Ophthalmology & Genetics, University of Genoa, Via de Toni 5, I-16132, Genoa, Italy.
Marinelli
L
L
Buccolieri
A
A
Trompetto
C
C
Abbruzzese
G
G
D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000175:diagnosis*; D050781:Transcranial Magnetic Stimulation