title: Dynamics of ocular surface topography in healthy subjects.
abstract: Our topography system is an enhancement of a standard TMS-1 corneal topograph instrument (Computed Anatomy Inc., New York, NY, USA). Topographic images are captured at a rate of 4 s(-1), allowing the recording of a series of 120 images in 30 s after a complete blink. In this prospective preliminary study 15 healthy volunteers were examined. The main outcome measures were the time profile of changes in surface regularity index (SRI), surface asymmetry index (SAI) and simulated keratometry values (K1, K2). After a blink there was a tendency for improvement in ocular surface regularity. Later trends were less clear. Our topography system makes possible the detailed evaluation of tear-film dynamics in the post-blink period. The new technique may play an important role in the diagnosis of various tear-film abnormalities; the results may also have significant implications in the planning of refractive surgeries.
authors.affiliation: Department of Ophthalmology, Semmelweis University, Tömö u. 25-29., H-1083 Budapest, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Erdélyi
authors.forename: Béla
authors.initials: B
authors.lastname: Csákány
authors.forename: Gábor
authors.initials: G
authors.lastname: Rödönyi
authors.forename: Alexandros
authors.initials: A
authors.lastname: Soumelidis
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lang
authors.forename: János
authors.initials: J
authors.lastname: Németh
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D001767:Blinking; D003315:Cornea / Q000502:physiology; D019781:Corneal Topography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012029:Refraction, Ocular; D013499:Surface Properties; D013666:Tears; D013997:Time Factors