title: Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin A.
abstract: OBJECTIVE
  To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).
  
  
  METHODS
  Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.
  
  
  RESULTS
  The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6%, P < 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P < 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P < 0.01), and showed significant difference from those in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.
authors.affiliation: Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China. xuezhong1968@sina.com
authors.forename: Xue-zhong
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Xu
authors.forename: Juan
authors.initials: J
authors.lastname: Jin
authors.forename: Xiu-qun
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ai-ling
authors.initials: AL
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy*; D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D015672:Erythroid Precursor Cells; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D010976:Platelet Count; D012156:Reticulocytes / Q000166:cytology; D013197:Stanozolol / Q000627:therapeutic use; D013607:Tablets
chemical_list: D000728:Androgens; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D013607:Tablets; C516453:shengxuening; D013197:Stanozolol; D016572:Cyclosporine