title: Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy.
abstract: Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.
authors.affiliation: Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. j.f.a.jansen@tue.nl
authors.forename: Jacobus F A
authors.initials: JF
authors.lastname: Jansen
authors.forename: Albert P
authors.initials: AP
authors.lastname: Aldenkamp
authors.forename: H J
authors.initials: HJ
authors.lastname: Marian Majoie
authors.forename: Rianne P
authors.initials: RP
authors.lastname: Reijs
authors.forename: Marc C T F M
authors.initials: MC
authors.lastname: de Krom
authors.forename: Paul A M
authors.initials: PA
authors.lastname: Hofman
authors.forename: M
authors.initials: M
authors.lastname: Eline Kooi
authors.forename: Klaas
authors.initials: K
authors.lastname: Nicolay
authors.forename: Walter H
authors.initials: WH
authors.lastname: Backes
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007806:Language Disorders / Q000139:chemically induced* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000503:physiopathology; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose