title: [Replacing systemic with topical corticotherapy in patients with generalized bullous pemphigoid and serious steroid-induced iatrogenesis].
abstract: We describe four patients with generalized bullous pemphigoid, who received treatment with oral prednisone and suffered serious corticosteroid-induced iatrogenesis. In all cases, we decided to quickly withdraw the systemic corticosteroid treatment and begin treatment with 0.05 % clobetasol propionate (20 g/day). New outbreaks of pemphigoid or significant side effects were not seen after this change in medication. The topical treatment went on for five to twelve months, and the patients were followed up for extended periods after treatment ended, with no recurrences being observed. Systemic corticosteroid treatment may be replaced by topical treatment without complications, and this may be especially indicated in patients with serious corticosteroid-induced iatrogenesis.
authors.affiliation: Servicio de Dermatología, Complejo Hospitalario de Pontevedra, España. igarciad@meditex.es
authors.forename: Ignacio
authors.initials: I
authors.lastname: García-Doval
authors.forename: Alberto
authors.initials: A
authors.lastname: Conde
authors.forename: Eugenia
authors.initials: E
authors.lastname: Mayo
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Cruces
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007049:Iatrogenic Disease; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D010391:Pemphigoid, Bullous / Q000188:drug therapy*; D011014:Pneumonia / Q000209:etiology; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D020521:Stroke / Q000150:complications
chemical_list: D007166:Immunosuppressive Agents; D002990:Clobetasol; D011241:Prednisone