Significance of small dense low-density lipoprotein as a risk factor for coronary artery disease and acute coronary syndrome.
Small dense LDL (sd-LDL) has recently emerged as an important coronary artery disease (CAD) risk factor. This study was performed to investigate how LDL particle size is related to CAD and acute coronary syndrome (ACS). Blood samples were collected from 504 patients that underwent coronary angiography to evaluate chest pain. The LDL particle size of these samples was measured. The mean LDL particle size was smaller in patients with angiographically proven CAD than in the controls (26.41 +/- 0.95 vs 26.73 +/- 0.64 nm, p < 0.001), and was negatively correlated with the Framingham risk score (r=-0.121, p=0.007). Patients with more extensive CAD had smaller LDL particles. LDL particle size was also smaller in patients with acute coronary syndrome as compared to non-ACS patients (26.09 +/- 1.42 vs 26.54 +/- 0.63 nm, p=0.011). These results suggest that sd-LDL is independently associated with the incidence and extent of CAD, and can be a risk factor for the development of ACS in the Korean population.
Kwon
Sung Woo
SW
Department of Internal Medicine, Yonsei University College of Medicine, Kangnam-gu, Seoul 135-720, Korea.
Yoon
Se-Jung
SJ
Kang
Tae Soo
TS
Kwon
Hyuck Moon
HM
Kim
Jeong-Ho
JH
Rhee
Jihyuk
J
Lee
Sung-Ju
SJ
Park
Jong-Kwan
JK
Lim
Jae Yun
JY
Yoon
Young Won
YW
Hong
Bum Kee
BK
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011237:Predictive Value of Tests; D012307:Risk Factors
D015415:Biomarkers; D008077:Lipoproteins, LDL