Evolution of CPV-2 and implication for antigenic/genetic characterization.
A few amino acid differences in the viral protein VP2 account for important antigenic and biological changes among feline parvovirus (FPV), canine parvovirus (CPV-2) and CPV-2 variants 2a and 2b. Several pieces of evidence suggest that CPV-2 is still evolving as additional amino acid changes occurred within the main antigenic regions of CPV-2 capsid, altering the antigenic profile of the virus and stressing the need for implementing the diagnostic assays.
Martella
Vito
V
Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, S.p. per Casamassima km 3, 70010, Valenzano, Bari, Italia. v.martella@veterinaria.uniba.it
Decaro
Nicola
N
Buonavoglia
Canio
C
D000818:Animals; D000940:Antigenic Variation / Q000235:genetics; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology; D036022:Capsid Proteins / Q000737:chemistry* / Q000276:immunology; D004285:Dogs; D019143:Evolution, Molecular; D017993:Parvovirus, Canine / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*
D000956:Antigens, Viral; D036022:Capsid Proteins