title: Pyrrolidine-thiourea as a bifunctional organocatalyst: highly enantioselective Michael addition of cyclohexanone to nitroolefins.
abstract: [reaction: see text] Asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol % of organocatalyst 2b and 10 mol % of n-butyric acid afford adducts 5 with high diastereoselectivities and enantioselectivities.
authors.affiliation: The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Cao
authors.forename: Meng-Chun
authors.initials: MC
authors.lastname: Ye
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003512:Cyclohexanones; D009574:Nitro Compounds; D011759:Pyrrolidines; D013890:Thiourea