Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection.
Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum.
Lean
I-Sarah
IS
Barts and the London School of Medicine, Institute of Cell and Molecular Science, Centre for Gastroenterology, Turner Street, London E1 2AD, United Kingdom.
Lacroix-Lamandé
Sonia
S
Laurent
Fabrice
F
McDonald
Vincent
V
D000818:Animals; D002460:Cell Line; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum / Q000276:immunology*; D004195:Disease Models, Animal; D020895:Enterocytes / Q000276:immunology*; D007113:Immunity, Innate; D051379:Mice; D018345:Mice, Knockout; D014409:Tumor Necrosis Factor-alpha / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha