Slight association between type 1 diabetes and "ff" VDR FokI genotype in patients from the Italian Lazio Region. Lack of association with diabetes complications.
BACKGROUND
Vitamin D receptor (VDR) mediates the effects of vitamin D. Our paper evaluates the FokI and BsmI VDR genotypes in 246 Caucasian (Italian from Lazio Region) T1DM patients compared with 246 Caucasian healthy controls, sharing age and gender and regional provenience with the patients. In addition, T1DM patients without complications were compared with those carrying three complications.


METHODS
Genotyping has been obtained by RFLP-PCR technique.


RESULTS
A slight significant association of T1DM with FokI homozygous "f" genotype was observed. No association was observed with the presence of multiple complications by a multivariate analysis.


CONCLUSIONS
T1DM patients showed slightly increased prevalence of "ff" VDR genotype.
Capoluongo
E
E
Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Largo A. Gemelli 8, 00168 Rome, Italy. ecapoluongo@rm.unicatt.it <ecapoluongo@rm.unicatt.it>
Pitocco
D
D
Concolino
P
P
Santonocito
C
C
Di Stasio
E
E
d'Onofrio
G
G
Manto
A
A
Giardina
B
B
Ghirlanda
G
G
Ameglio
F
F
Zuppi
Cecilia
C
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D048909:Diabetes Complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics; D003929:Diabetic Neuropathies / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D012044:Regression Analysis
C053864:endodeoxyribonuclease BsmI; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific