T cells climb on board Blimp-1.
B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.
Jameson
Stephen C
SC
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. james024@umn.edu
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D049109:Cell Proliferation; D003092:Colitis / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology / Q000502:physiology*
D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1