title: The real-time, three-dimensional analyses of benign and malignant skin tumors by confocal laser scanning microscopy.
abstract: BACKGROUND
  In obtain images of skin tumors non-invasively with real-time, confocal laser scanning microscope (CLSM) is introduced.
  
  
  OBJECTIVE
  Reconstructed images of given horizontal sections were converted into three-dimensions using the data set of a large number of tomograms in the horizontal directions.
  
  
  METHODS
  To develop the multiplaner reconstruction images of skin tumors in vertical directions and three-dimensionally reconstructed images of tumors will be obtained from the continuously collected horizontal image data sets.
  
  
  RESULTS
  Three-dimensional analyses of the skin tumors from reconstructed images of the CLSM scanning have provided the information as to their physiological characteristics as well as the extent of deep invasion in real-time with non-invasive manner. High performance three-dimensional conversion software was effective in displaying three-dimensional construction of skin tumors.
  
  
  CONCLUSIONS
  The CLSM scanning images followed by three-dimensional reconstruction using them can provide the real-time and non-invasive diagnoses of skin tumors and analyze the radial growth phase of tumors and the three-dimensional growth characteristics.
authors.affiliation: Sapporo Medical University School of Medicine, Department of Dermatology, Sapporo, Hokkaido 060-8543, Japan. ichiro@sapmed.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ono
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakemoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Ogino
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Kowichi
authors.initials: K
authors.lastname: Jimbow
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008545:Melanoma / Q000473:pathology; D018613:Microscopy, Confocal; D009508:Nevus, Pigmented / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*