title: Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.
abstract: Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer.
authors.affiliation: Abbott Laboratories, North Chicago, Illinois 60064.
authors.forename: J C
authors.initials: JC
authors.lastname: Mao
authors.forename: E E
authors.initials: EE
authors.lastname: Robishaw
authors.forename: L R
authors.initials: LR
authors.lastname: Overby