title: [The relationship between serum adiponectin level and serum alanine aminotransferase elevation in Korean male with nonalcoholic fatty liver disease].
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) comprises a large part of chronic liver diseases. Recently it was reported that adipokines are closely associated with the common risk factors for NAFLD, such as obesity, diabetes, dyslipidemia, and insulin resistance. We aimed to evaluate the changes in serum adiponectin, resistin and leptin concentrations related to alanine aminotransferase (ALT) elevations in Korean men with NAFLD.
  
  
  METHODS
  We studies 38 men who were diagnosed with fatty liver by abdominal ultrasonography. None had a history of excessive alcohol consumption, autoimmune hepatitis, inherited or metabolic liver disease or viral hepatitis. The subjects were divided into two groups. One group had normal levels of ALT (n=28) and the other had increased ALT (n=10). We compared anthropometrical parameters, biochemical items and serum adipokine levels between these two groups.
  
  
  RESULTS
  Serum adiponectin levels were lower in the increased ALT group than in the normal ALT group (3.89 +/- 1.77 vs 7.01 +/- 2.54 microgram/dL, P=0.001). But there were no significant differences in serum leptin and resistin levels between two groups (4.02 +/- 2.04 vs 3.26 +/- 1.41 ng/mL, p=0.245, 80.14 +/- 14.8 vs 80.5 +/- 11.34 ng/mL, P=0.937, respectively). Multiple linear regression analyses demonstrated that the serum adiponectin level is inversely correlated with serum ALT level and that the serum aspartate aminotransferase (AST) level is positively correlated with the serum ALT level.
  
  
  CONCLUSIONS
  Our study shows that hypoadiponectinemia is associated with an ALT elevation in patients with NAFLD. Adiponectin may play an indirect role in the development of NAFLD.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yong Su
authors.initials: YS
authors.lastname: Lee
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Cho
authors.forename: Ji Cheul
authors.initials: JC
authors.lastname: Pae
authors.forename: Se Yong
authors.initials: SY
authors.lastname: Oh
authors.forename: Mun Su
authors.initials: MS
authors.lastname: Kang
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Hong Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.forename: Chong Il
authors.initials: CI
authors.lastname: Sohn
authors.forename: Woo Kyu
authors.initials: WK
authors.lastname: Jeon
authors.forename: Byung Ik
authors.initials: BI
authors.lastname: Kim
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Yun
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Oh
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D005234:Fatty Liver / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood
chemical_list: D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D000410:Alanine Transaminase