title: Towards an understanding of the role of forces in carcinogenesis: a perspective with therapeutic implications.
abstract: Carcinogenesis may aberrantly have as its source an underlying dynamic which likely operates in accord with or is expressive of a universal principle of force. This drive can be seen as a type of necessary completion of force configurations giving forth a force-based, completing guidance or dyneotaxis. This completing guidance is a completing communication. Aberrations of this drive can manifest as incomplete communication arising from incomplete or non-uniform force-configurations throughout different levels of organization within the organism. Such non-uniformities of force-configuration manifest themselves through intra- and intercellular distortion. This is represented by changes or distortions within cellular and tissue architecture, or shape, occurring through and enabling a non-uniform loosening. Cycles of non-uniform loosening and distortion would generate a progressive disruption or aberration in an otherwise further adhesively completing, thereby further stabilizing, dyneotaxis. Carcinogenesis ensues as an aberrant means to re-establish a uniformity or symmetry of adhesive and mechanical forces in such tissues, and within the genome. However, it rather results in a further loosening-based reorganization or reshaping. This would be a manifestation of a still further non-uniformity of forces. Uncontrolled mutagenesis, itself stemming from genomic distortion, is also seen as a process that could lead to loosening and further distortion throughout the cell, and thereby, a contributor to carcinogenesis if a transcellular, globally completive or uniform adhesiveness cannot be maintained. A therapeutic approach could be employed to reverse such a cycle of loosening and distortion within cellular and tissue organization. The developmental reversal of carcinogenesis would be the consequence. Such an approach could be through the application of a coherent, uniform and united array of guiding mechanical and electromagnetic forces. The deeper consequence would be the re-establishment of a global, cancer-countering, uniform or symmetrical, guiding adhesiveness via and dependent on a complete and non-distorted network of cellular and intercellular structures, further completing, and thus further stabilizing, such structures in the process.
authors.affiliation: Genadyne Consulting, Berkeley, CA 94707, USA. michaellieber@juno.com
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lieber
mesh_terms: D001696:Biomechanical Phenomena; D002450:Cell Communication; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000628:therapy