title: Immunohistochemical expression of EGFR and p-EGFR in oral squamous cell carcinomas.
abstract: Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family, which is expressed or highly expressed in a variety of solid tumors, including oral cancers. High EGFR expression has been correlated with tumor size, metastasis and survival. In recent years, EGFR has been considered a promising target for monoclonal antibody therapy. A total of 52 patients with oral squamous cell carcinoma (OSCC) were selected for EGFR and phosphorylated EGFR (p-EGFR) detection. Immunohistochemical staining was performed to evaluate EGFR and p-EGFR expression. Positive EGFR and p-EGFR staining was present in 92.3% (48/52) and 98.0% (51/52) of all cases, respectively. High EGFR and p-EGFR expression was present in 63.4% (33/52) and 69.2% (36/52) of all cases, respectively. EGFR and p-EGFR expression did not correlate with the clinical factors tumor stage, regional lymph node metastasis, or distant metastasis. However, a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. As a conclusion, the majority of OSCCs highly express EGFR and p-EGFR, indicating the importance of studying the efficacy of anticancer therapy targeting these signal factors.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Wakayama, 641-8509, Japan. hiraishi@wakayama-med.ac.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hiraishi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
authors.forename: Ken
authors.initials: K
authors.lastname: Nakatani
authors.forename: Kenji
authors.initials: K
authors.lastname: Negoro
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D003627:Data Interpretation, Statistical; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010766:Phosphorylation
chemical_list: D066246:ErbB Receptors