title: Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study.
abstract: Methyl mercury (MeHg) is highly toxic to the developing nervous system. Human exposure is mainly from fish consumption since small amounts are present in all fish. Findings of developmental neurotoxicity following high-level prenatal exposure to MeHg raised the question of whether children whose mothers consumed fish contaminated with background levels during pregnancy are at an increased risk of impaired neurological function. Benchmark doses determined from studies in New Zealand, and the Faroese and Seychelles Islands indicate that a level of 4-25 parts per million (ppm) measured in maternal hair may carry a risk to the infant. However, there are numerous sources of uncertainty that could affect the derivation of benchmark doses, and it is crucial to continue to investigate the most appropriate derivation of safe consumption levels. Earlier, we published the findings from benchmark analyses applied to the data collected on the Seychelles main cohort at the 66-month follow-up period. Here, we expand on the main cohort analyses by determining the benchmark doses (BMD) of MeHg level in maternal hair based on 643 Seychellois children for whom 26 different neurobehavioral endpoints were measured at 9 years of age. Dose-response models applied to these continuous endpoints incorporated a variety of covariates and included the k-power model, the Weibull model, and the logistic model. The average 95% lower confidence limit of the BMD (BMDL) across all 26 endpoints varied from 20.1 ppm (range=17.2-22.5) for the logistic model to 20.4 ppm (range=17.9-23.0) for the k-power model. These estimates are somewhat lower than those obtained after 66 months of follow-up. The Seychelles Child Development Study continues to provide a firm scientific basis for the derivation of safe levels of MeHg consumption.
authors.affiliation: Department of Community and Preventive Medicine, 601 Elmwood Avenue, Box 644, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. edwin_van_wijngaarden@urmc.rochester.edu
authors.forename: Edwin
authors.initials: E
authors.lastname: van Wijngaarden
authors.forename: Christopher
authors.initials: C
authors.lastname: Beck
authors.forename: Conrad F
authors.initials: CF
authors.lastname: Shamlaye
authors.forename: Elsa
authors.initials: E
authors.lastname: Cernichiari
authors.forename: Philip W
authors.initials: PW
authors.lastname: Davidson
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Myers
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Clarkson
mesh_terms: D000818:Animals; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D005260:Female; D005399:Fishes; D005500:Follow-Up Studies; D005506:Food Contamination; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D008452:Maximum Allowable Concentration; D020262:Mercury Poisoning, Nervous System / Q000209:etiology / Q000503:physiopathology; D008767:Methylmercury Compounds / Q000032:analysis*; D015233:Models, Statistical; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012750:Seychelles / Q000453:epidemiology
chemical_list: D008767:Methylmercury Compounds