Posttransplant diabetes mellitus in liver transplant recipients.
BACKGROUND
Approximately 20% of liver transplant recipients develop posttransplant diabetes mellitus. Hepatitis C, a leading indication for liver transplantation, has been identified as a risk factor for posttransplant diabetes mellitus and is an observation that is not well described.


OBJECTIVE
To evaluate the incidence of posttransplant diabetes mellitus and risk factors associated with this condition.


METHODS
A retrospective chart review.


METHODS
A large urban transplant center.


METHODS
One hundred fifteen liver transplant recipients who received a transplant between January 1, 1998, and August 31, 2001.


RESULTS
The rate of posttransplant diabetes mellitus, calculated at 3-month intervals in the first year after liver transplantation, ranged from 19.4% to 24.6%, which is similar to the averages reported in most published studies. The cumulative rate of posttransplant diabetes mellitus, which includes all patients who developed this condition during the time studied, was 31.3%. Clinical and demographic factors, including immunosuppression regimens, were similar between patients with and without posttransplant diabetes mellitus. Two risk factors for posttransplant diabetes mellitus were identified: hepatitis C, which was the leading indication for transplantation in this group (54.8%), and cytomegalovirus infection during the first year after transplantation. Other clinical and demographic variables, such as gender, age, ethnicity, rejection episodes, body mass index, and immunosuppression, were not identified as risk factors for posttransplant diabetes mellitus in liver transplant recipients.
Driscoll
Carolyn J
CJ
University of Tennessee Health Science Center, Memphis, Tenn, USA.
Cashion
Ann K
AK
Hathaway
Donna K
DK
Thompson
Carol
C
Conley
Yvette
Y
Gaber
Osama
O
Vera
Santiago
S
Shokouh-Amiri
Hosein
H
D000704:Analysis of Variance; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000821:virology; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000601:surgery; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D015994:Incidence; D008107:Liver Diseases / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000821:virology; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology