Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX).
A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH(3)COO](-), m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 --> 147 and m/z 355 --> 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 microg/L and good linearity was achieved in the range 5-500 microg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.
Pan
Xiaoping
X
The Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409-1163, USA. xiaoping.pan@tiehh.ttu.edu
Zhang
Baohong
B
Tian
Kang
K
Jones
Lindsey E
LE
Liu
Jun
J
Anderson
Todd A
TA
Wang
Jia-Sheng
JS
Cobb
George P
GP
D001392:Azocines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods; D053834:Explosive Agents / Q000032:analysis*; D006573:Heterocyclic Compounds, 1-Ring / Q000032:analysis*; D012680:Sensitivity and Specificity; D012987:Soil / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D001392:Azocines; D053834:Explosive Agents; D006573:Heterocyclic Compounds, 1-Ring; D012987:Soil; C007950:octogen