title: Controversial endocrine interventions for the aged.
abstract: Specific endocrine changes occur with the ageing process. The last decade has witnessed significant progress in the basic and clinical science of ageing, thereby rejuvenating the interest in anti-ageing medicine, especially that of hormone replacement, by medical professionals and the lay public. However, endocrine manipulation as a therapeutic strategy for ageing is still evolving as continuing research attempts to answer the many questions of what it can achieve at the risk of incurring unknown long-term adverse effects. The current day doctor is confronted with a host of options, and will benefit from a synopsis of the latest evidence before making the most appropriate decision for aged patients seeking hormonal replacement therapy as a means to counter the effects of ageing. This review aims to give a rapid overview of the endocrine profile of geriatric population and the studies on the more controversial hormonal replacement therapies for the aged.
authors.affiliation: Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore. mleowsj@massmed.org
authors.forename: M K S
authors.initials: MK
authors.lastname: Leow
authors.forename: K C
authors.initials: KC
authors.lastname: Loh
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D003687:Dehydroepiandrosterone / Q000502:physiology / Q000627:therapeutic use; D004703:Endocrine System / Q000502:physiology*; D013006:Growth Hormone / Q000502:physiology / Q000627:therapeutic use; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology / Q000627:therapeutic use; D008550:Melatonin / Q000502:physiology / Q000627:therapeutic use; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use
chemical_list: D013739:Testosterone; D003687:Dehydroepiandrosterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D008550:Melatonin