title: Highly efficient synthesis of enantiopure diacetylated C(2)-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT).
abstract: Highly efficient synthesis of enantiopure diacetates of 2,4-pentanediol and 2,5-hexanediol starting from commercially available mixtures of the diols (dl/meso approximately 1:1) has been realized by combining a fast ruthenium-catalyzed epimerization with an enzymatic transesterification. The in situ coupling of these two processes produces the diacetates in high yield in >99 % enantiomeric excess.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden.
authors.forename: Belén
authors.initials: B
authors.lastname: Martín-Matute
authors.forename: Michaela
authors.initials: M
authors.lastname: Edin
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D006018:Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D006018:Glycols; D009942:Organometallic Compounds; C007938:2,5-hexanediol; C065140:2,4-pentanediol; D012428:Ruthenium; D008049:Lipase