p53 aerobics: the major tumor suppressor fuels your workout.
In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.
Kruse
Jan-Philipp
JP
Institute for Cancer Genetics, and Department of Pathology, College of Physicians & Surgeons, Columbia University, 1150 St. Nicholas Ave, New York, New York 10032, USA.
Gu
Wei
W
D000332:Aerobiosis; D000818:Animals; D002352:Carrier Proteins; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D006019:Glycolysis; D006801:Humans; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D010101:Oxygen Consumption / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000378:metabolism*
D002352:Carrier Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D011506:Proteins; C400285:SCO2 protein, human; C511423:SCO2 protein, mouse; D016159:Tumor Suppressor Protein p53; D003576:Electron Transport Complex IV