PACAP 38 as a modulator of immune and endocrine responses during LPS-induced acute inflammation in rats.
The effect of PACAP 38 administration on neuroendocrine and immune parameters was examined in rats with LPS-induced peritonitis. Treatment with PACAP 38 alone did not influence the serum level of the cytokines and hormones examined, but significantly decreased immune cell activity. When administered together with LPS, PACAP 38 reversed its effect on immune and humoral parameters, causing a decrease in the serum concentrations of TNFalpha and corticosterone, and an increase in T4 and GH. The majority of PACAP 38 effects disappeared earlier than those previously observed for VIP. PACAP 38 appears to represent a short-lasting modulator of immune and endocrine responses during acute inflammation.
Bik
Wojciech
W
Neuroendocrinology Department, Medical Centre of Postgraduate Education, Marymoncka 99, 01-813 Warsaw, Poland. zncmkp@op.pl
Wolinska-Witort
Ewa
E
Pawlak
Joanna
J
Skwarlo-Sonta
Krystyna
K
Chmielowska
Magdalena
M
Martynska
Lidia
L
Baranowska-Bik
Agnieszka
A
Baranowska
Boguslawa
B
D000208:Acute Disease; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D004347:Drug Interactions / Q000276:immunology; D013006:Growth Hormone / Q000097:blood; D018836:Inflammation Mediators / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008070:Lipopolysaccharides; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000276:immunology*; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000276:immunology*; D010538:Peritonitis / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D051381:Rats; D011921:Rats, Inbred WKY; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013974:Thyroxine / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014409:Tumor Necrosis Factor-alpha; D013006:Growth Hormone; D013974:Thyroxine; D003345:Corticosterone