Low-grade gliomas in adults.
Low-grade gliomas are a heterogeneous group of neoplasms usually encountered in younger patient populations. These tumors represent a unique challenge because most patients will survive a decade or more and may be at a higher risk for treatment-related complications. Clinical observations over the years have identified a subset of low-grade gliomas that tends to manifest more aggressive clinical behavior and require earlier, more aggressive intervention. Clinical and molecular parameters may allow better assessment of prognosis and application of risk-adjusted management strategies that may include resection, radiation, or chemotherapy. Improved methods of long-term cognitive and functional assessment are desperately needed in this patient population.
Grier
Jeanine T
JT
Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Batchelor
Tracy
T
D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005910:Glioma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis