title: Biomimetic phosphorylcholine polymer grafting from polydimethylsiloxane surface using photo-induced polymerization.
abstract: The biomimetic synthetic phospholipid polymer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has improved the surface property of biomaterials. Both hydrophilic and anti-biofouling surfaces were prepared on polydimethylsiloxane (PDMS) with MPC grafted by surface-initiated photo-induced radical polymerization. Benzophenone was used as the photoinitiator. The quantity of the adsorbed initiator on PDMS was determined by UV absorption and ellipsometry. The poly(MPC)-grafted PDMS surfaces were characterized by XPS, ATR-FTIR and static water contact angle (SCA) measurements. The SCA on PDMS decreased from 115 degrees to 25 degrees after the poly(MPC) grafting. The in vitro single protein adsorption on the poly(MPC)-grafted PDMS decreased 50-75% compared to the unmodified PDMS. The surface friction of the poly(MPC)-grafted PDMS was lower than the unmodified PDMS under wet conditions. The oxygen permeability of the poly(MPC)-grafted PDMS was as high as the unmodified PDMS. The tensile property of PDMS was maintained at about 90% of the ultimate stress and strain after the poly(MPC) grafting. The surface-modified PDMS is expected to be a novel medical elastomer which possesses an excellent surface hydrophilicity, anti-biofouling property, oxygen permeability and tensile property.
authors.affiliation: Department of Materials Engineering, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Goda
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Konno
authors.forename: Madoka
authors.initials: M
authors.lastname: Takai
authors.forename: Toru
authors.initials: T
authors.lastname: Moro
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D004129:Dimethylpolysiloxanes / Q000138:chemical synthesis / Q000737:chemistry*; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010539:Permeability; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D010777:Photochemistry / Q000379:methods*; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D012828:Silicones / Q000138:chemical synthesis / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D004129:Dimethylpolysiloxanes; D008689:Methacrylates; D011108:Polymers; D011506:Proteins; D012828:Silicones; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; C013830:baysilon; D010100:Oxygen