Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.
Rukin
Nicholas J
NJ
Human Disease and Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire ST4 7PX, United Kingdom.
Luscombe
Christopher
C
Moon
Sam
S
Bodiwala
Dhaval
D
Liu
Samson
S
Saxby
Mark F
MF
Fryer
Anthony A
AA
Alldersea
Julie
J
Hoban
Paul R
PR
Strange
Richard C
RC
D001483:Base Sequence; D017931:DNA Primers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D014466:Ultraviolet Rays
D017931:DNA Primers; D018167:Receptors, Calcitriol