title: Maternal smoking during pregnancy and possible effects of in utero testosterone: evidence from the 2D:4D finger length ratio.
abstract: OBJECTIVE
  Maternal smoking during pregnancy is linked to high fetal testosterone (FT), and an increased risk in offspring for autism, ADHD, conduct disorder, antisocial behaviour and criminal outcomes. The ratio of the length of the 2nd and 4th fingers (2D:4D) is thought to be negatively related to FT concentration, and is related to autism, hyperactivity, poor social behaviour, and physical aggression. We compare the 2D:4D ratio of children whose mothers smoked during pregnancy with the 2D:4D of children whose mother did not smoke.
  
  
  METHODS
  Cross-sectional survey in two primary schools. Questionnaires were distributed to 710 children and 546 were returned. Of these the 2nd and 4th digits of 520 children (259 females and 261 males) were measured. The main outcome measures were 2nd and 4th digit length, smoking history of mother and father.
  
  
  RESULTS
  Boys had lower mean 2D:4D than girls and right 2D:4D was lower than left. Among boys, those whose mother's smoked during pregnancy had lower right hand 2D:4D ratio than those whose mother did not smoke. The difference remained significant after the effects of age, height, weight and birth weight were removed. Other household smoking patterns were not associated with male offspring 2D:4D. Female offspring 2D:4D did not differ on the basis of maternal smoking.
  
  
  CONCLUSIONS
  Maternal smoking during pregnancy was associated with low right 2D:4D in children, but the effect was restricted to boys. A link between maternal smoking during pregnancy and 2D:4D supports a causal association between FT and such behaviours as hyperactivity and conduct disorder.
authors.affiliation: Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QE, UK.
authors.forename: S
authors.initials: S
authors.lastname: Rizwan
authors.forename: J T
authors.initials: JT
authors.lastname: Manning
authors.forename: B J
authors.initials: BJ
authors.lastname: Brabin
mesh_terms: D000704:Analysis of Variance; D001837:Body Weights and Measures; D002648:Child; D004739:England; D005260:Female; D005385:Fingers / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D012737:Sex Factors; D012907:Smoking; D011795:Surveys and Questionnaires