Re-analysis of the Xq27-Xq28 region suggests a weak association of an X-linked gene with sporadic testicular germ cell tumour without cryptorchidism.
BACKGROUND
A testicular germ cell tumour (TGCT) predisposing gene has been mapped to the Xq27 region on the X chromosome. These linkage findings remain to be confirmed by other studies.


METHODS
In 276 patients and 169 unaffected first-degree male relatives, 12 microsatellite markers covering the candidate region were genotyped and used to study possible association of TGCT with Xq27.


RESULTS
In contrast to previously reported linkage of familial TGCT and cryptorchidism with Xq27, we observed an association between the subset of TGCT cases without a family history of TGCT or cryptorchism and marker DXS1193 (p=0.014). Carriers of minor alleles were at increased risk (odds ratio (OR) 4.7, confidence interval (CI) 1.1-19.6)


CONCLUSIONS
We found an association on Xq27 in a subset of TGCT cases, which suggests the presence of an X-linked gene that slightly or moderately increases risk to develop sporadic TGCT but not cryptorchidism.
Lutke Holzik
M F
MF
Department of Surgical Oncology, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Hoekstra
H J
HJ
Sijmons
R H
RH
Sonneveld
D J A
DJ
van der Steege
G
G
Sleijfer
D Th
DT
Nolte
I M
IM
D041321:Chromosomes, Human, X / Q000235:genetics*; D050172:Genes, X-Linked / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010375:Pedigree; D013736:Testicular Neoplasms / Q000235:genetics*