title: Novel Rh catalysis in cross-coupling between alkyl halides and arylzinc compounds possessing ortho-COX (X = OR, NMe2, or Ph) groups.
abstract: [reaction: see text] Rh-dppf was found to be an efficient catalyst for the cross-coupling between primary alkyl halides bearing beta-hydrogens and arylzinc compounds possessing carbonyl groups such as ester, amide, or ketone at the ortho position. Various functional groups such as ester, nitrile, or acyloxylate moieties on the halides were tolerated under the catalysis conditions. Arylzinc compounds free of ortho-carbonyl groups reacted well with ethyl 3-iodopropanoate, suggesting that the essential intramolecular interaction between carbonyl groups and Rh promotes the reductive elimination.
authors.affiliation: Department of Chemistry, Faculty of Science, Okayama University, Tsushima, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shinya
authors.initials: S
authors.lastname: Inagaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nishihara
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi