[Use of inhibitors of the angiotensin-converting enzyme and the beta-adrenoblocker metoprolol combined in treatment of chronic cardiac insufficiency].
Clinical-and-hemodynamic effects were studied of a supplementary use of a selective beta-adrenoblocker metoprolol in an ongoing therapy of chronic cardiac insufficiency (CCI) with inhibitors of the angiotensin-converting enzyme (ACEI) and diuretics. It has been found out that long (over 8 weeks) course of therapy supplemented with metoprolol results in improvement of the left ventricular systolic function and lowering of the functional class. Long-term administration of metoprolol enhances tolerance to a graded physical exercise in CCI patients, which observation is accompanied by a more economic character of its performance. The findings secured validate the expediency of a supplementary use of the beta-adrenoblocker metoprolol in the routine regimen of the supporting treatment of CCI patients involving the use of ACEI plus a diuretic.
Voronkov
L G
LG
Serdiuk
T E
TE
Riabenko
D V
DV
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D025401:Echocardiography, Stress; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D008790:Metoprolol