Lessons from Coley's Toxin.
The active molecule in Coley's Toxin is not tumor necrosis factor (TNF) or endotoxin (LPS), but interleukin-12 (IL-12). IL-12 holds the key to improved anti-tumor immuns response.
Tsung
Kangla
K
Department of Surgery, Stanford University School of Medicine, Room H3591, 300 Pasteur Drive, Stanford, CA 94025, USA.
Norton
Jeffrey A
JA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism*; D004731:Endotoxins / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D018664:Interleukin-12 / Q000737:chemistry*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D048069:Tumor Necrosis Factors / Q000737:chemistry
D000970:Antineoplastic Agents; D016207:Cytokines; D004731:Endotoxins; D048069:Tumor Necrosis Factors; D018664:Interleukin-12