title: Effect of cell culture conditions on the anticytomegalovirus activity of maribavir.
abstract: The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.
authors.affiliation: Medical and Research Services, VA Medical Center and Oregon Health & Scince University, Portland, OR 97239, USA. chous@ohsu.edu
authors.forename: Sunwen
authors.initials: S
authors.lastname: Chou
authors.forename: Laura C
authors.initials: LC
authors.lastname: Van Wechel
authors.forename: Gail I
authors.initials: GI
authors.lastname: Marousek
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development*; D005347:Fibroblasts / Q000821:virology; D017930:Genes, Reporter; D006801:Humans; D008168:Lung / Q000166:cytology / Q000821:virology; D012263:Ribonucleosides / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000821:virology; D014776:Virus Cultivation / Q000379:methods; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
chemical_list: D000469:Alkaline Phosphatase; D000998:Antiviral Agents; D001562:Benzimidazoles; D012263:Ribonucleosides; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole