title: Experimental supratrigonal cystectomy. Evaluation of long-term complications.
abstract: OBJECTIVE
  The present study aims at assessing the occurrence of pyelonephritis and long-term complications in rats submitted to surgical reduction of bladder capacity.
  
  
  METHODS
  Sprague-Dawley rats were submitted to supratrigonal cystectomy (animals) or sham operation ( animals) and sacrificed 2, 4 and 6 months after the surgical procedure. The arterial blood pressure and serum creatinine levels were assessed before the surgery and at the time of the sacrifice. After the sacrifice a careful inspection of the urinary apparatus was performed to the characterization of the hydronephrosis and for the detection of the presence of calculi. With sterile technique, the urine was aspirated from the bladder and the kidneys removed and sent to a microbiologic study.
  
  
  RESULTS
  Pyelonephritis was frequent in animals submitted to supratrigonal cystectomy. The most frequent and isolated microorganisms were Staphylococcus sp. and E. coli. The presence of urinary calculi was correlated significantly to the presence of urinary tract infection (p < 0.003). Arterial hypertension was frequent amongst animals submitted to supratrigonal cystectomy. Serum creatinine was high in 72.4% of the animals in the group submitted to supratrigonal cystectomy. The presence of calculi and pyelonephritis were frequent in rats presenting renal insufficiency and in hypertensive rats.
  
  
  CONCLUSIONS
  The long-term course of urinary infection in rats submitted to supratrigonal cystectomy was characterized by a high incidence of renal insufficiency and arterial hypertension that seem to be related to dysfunction and bladder obstruction induced by an extensive surgical procedure and the presence of urolithiasis and pyelonephritis.
authors.affiliation: Section of Urology, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. nefro@ufba.br
authors.forename: Milton
authors.initials: M
authors.lastname: Barros
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Martinelli
authors.forename: Heonir
authors.initials: H
authors.lastname: Rocha
mesh_terms: D000818:Animals; D015653:Cystectomy / Q000009:adverse effects*; D004195:Disease Models, Animal; D006973:Hypertension / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications; D011704:Pyelonephritis / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000209:etiology; D013997:Time Factors; D014545:Urinary Calculi / Q000209:etiology; D014552:Urinary Tract Infections / Q000209:etiology; D014570:Urologic Diseases / Q000209:etiology*