Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice.
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, delayed the development of seizure responses and mildly shortened the duration of convulsion of genetically epileptic EL mice. mRNA levels of IL-1beta, IL-6 and TNF-alpha before seizure and mRNA levels of IL-6 and TNF-alpha after seizure were decreased in the brains of the mice with pioglitazone. These results suggest that pioglitazone may have ameliorative effects on epileptic seizure responses partly through the reduction of inflammatory responses in the brain.
Okada
Kazumasa
K
Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan. gion@med.uoeh-u.ac.jp
Yamashita
Uki
U
Tsuji
Sadatoshi
S
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D000077205:Pioglitazone; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012640:Seizures / Q000188:drug therapy*; D045162:Thiazolidinediones / Q000627:therapeutic use*
D000927:Anticonvulsants; D016207:Cytokines; D012333:RNA, Messenger; D045162:Thiazolidinediones; D051546:Cyclooxygenase 2; D000077205:Pioglitazone