title: [Analysis of human H5N1 virus hemagglutinin gene isolated from the mainland of China].
abstract: BACKGROUND
  To analyze the genetic and antigenic characteristics of human H5N1 virus isolated from the mainland of China.
  
  
  METHODS
  The hemagglutinin (HA) gene of human H5N1 virus were sequenced and analyzed.
  
  
  RESULTS
  The results of HA gene sequencing showed that all the virus isolates belong to the same group because of the high similarity, but they were different from the virus isolated from Thailand and Vietnam. The sequence data also showed that the receptor specificity and the connecting peptide between HA1 and HA2 are still avian influenza origin.
  
  
  CONCLUSIONS
  The virus isolates from mainland of China until now belong to the same group and are different from the virus isolated from Thailand and Vietnam, and there is no evidence showing the human-avian influenza reassortant and recombination.
authors.affiliation: Chinese Influenza Center, Institute for Viral Disease Control and Prevention, State Key Laboratory for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. yshu@vip.sina.com
authors.forename: Yue-long
authors.initials: YL
authors.lastname: Shu
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.forename: Le-ying
authors.initials: LY
authors.lastname: Wen
authors.forename: Xin-sheng
authors.initials: XS
authors.lastname: Zhao
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Shu-min
authors.initials: SM
authors.lastname: Duan
authors.forename: Kai
authors.initials: K
authors.lastname: Nie
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Da-yan
authors.initials: DY
authors.lastname: Wang
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Yao
authors.forename: Yuan-ji
authors.initials: YJ
authors.lastname: Guo
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002681:China; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus