Density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.
The adenovirus 7-simian virus 40 hybrid virus population E46(+) was subjected to fixed-angle equilibrium density gradient centrifugation in CsCl. A difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. This difference in buoyant density appeared to be accentuated in a population of adenovirus 2(+t7), a derivative of E46(+) in which the adenovirus 7-simian virus 40 genome had been transferred to an adenovirus 2 capsid.
Baum
S G
SG
Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
Wiese
W H
WH
Rowe
W P
WP