Teratological study of the herbicide 4-chloro-2-methylphenoxyacetic acid in rabbits.
4-Chloro-2-methylphenoxyacetic acid (MCPA) is an aryloxyacetic acid derivative categorised as a plant hormone herbicide. The aim of the study was to evaluate the effect of MCPA on pregnant females and the prenatal development of rabbits. The substance tested was administered orally to pregnant New Zealand White rabbits from day 6 to day 27 of gestation at doses of 5, 10 and 25 mg kg(-1) day(-1). The animals were killed on day 28 of gestation and live fetuses were examined for gross, skeletal and visceral anomalies. Administration of MPCA did not induce any signs of maternal toxicity. There was a significant decrease of fetal and placental weight compared with controls at the highest dose of MPCA. No adverse effect of the substance tested was seen on uterine content variables, e.g. corpora lutea, pre-implantation and post-implantation loss, early, late resorptions, live and dead fetuses and sex ratio. Rabbit fetuses treated with the middle and highest doses of MPCA had a significantly elevated incidence of skull and pelvic bone delays. In conclusion, prenatal administration of MCPA did not exhibit a teratogenic effect on rabbit fetus development.
Ujházy
E
E
Institute of Experimental Pharmacology, SASc., Dúbravská cesta 9, Bratislava, Slovakia. exfaujha@savba.sk
Sadlonová
I
I
Dubovický
M
M
Mach
M
M
Múcková
M
M
Flaskárová
E
E
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000008:administration & dosage / Q000633:toxicity*; D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D020567:Fetal Weight; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size; D010384:Pelvic Bones / Q000002:abnormalities*; D010920:Placenta / Q000187:drug effects; D010929:Placentation; D011247:Pregnancy; D011817:Rabbits; D012886:Skull / Q000002:abnormalities*
D006540:Herbicides; D008456:2-Methyl-4-chlorophenoxyacetic Acid