Feminization and reduction of testicular weight in mouse sparganosis.
After infection of male mice with the plerocercoids (spargana) of Spirometra mansoni, serum levels of estrogen and testicular weight were analyzed by enzyme-linked immunosorbent assay (ELISA) and weighing machine, respectively. The serum level of estrogen increased progressively in infected mice compared with normal controls, whereas the testicular weight of infected mice decreased significantly (P < 0.05). These results suggest that certain substances from spargana change the steroid hormone metabolisms in the host by unknown pathways, and chronic infection may contribute to change of the function of steroid hormone target organ, i.e., testis, in male mice.
Yang
Hyun-Jong
HJ
Department of Parasitology and Ewha Medical Research Center, College of Medicine, Ewha Womans University, Seoul, 158-710, Korea. parayang@ewha.ac.kr
D000818:Animals; D004967:Estrogens / Q000097:blood; D005262:Feminization / Q000469:parasitology*; D008297:Male; D051379:Mice; D009929:Organ Size; D013031:Sparganosis / Q000150:complications*; D013737:Testis / Q000469:parasitology* / Q000473:pathology; D013997:Time Factors
D004967:Estrogens