title: Nature: a rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy.
abstract: The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (lambda (max) 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the chemistry, preclinical results, and brief clinical data of some of the most effective photosensitizers. The utility of the tumor-avid photosensitizers in developing multimodality agents (imaging and therapy) is also presented.
authors.affiliation: Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. Ravindra.Pandey@roswellpark.org
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Pandey
authors.forename: Lalit N
authors.initials: LN
authors.lastname: Goswami
authors.forename: Yihui
authors.initials: Y
authors.lastname: Chen
authors.forename: Amy
authors.initials: A
authors.lastname: Gryshuk
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Missert
authors.forename: Allan
authors.initials: A
authors.lastname: Oseroff
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Dougherty
mesh_terms: D025541:Bacteriochlorophyll A / Q000737:chemistry / Q000494:pharmacology; D002734:Chlorophyll / Q000737:chemistry / Q000494:pharmacology; D003952:Diagnostic Imaging; D037741:Fullerenes; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D025541:Bacteriochlorophyll A; D037741:Fullerenes; D017319:Photosensitizing Agents; D002734:Chlorophyll