title: Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression.
abstract: The dysregulation of the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis system is one of the major neuroendocrine abnormalities in major depression (MD). Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression. In this article, whether genetic variations in the corticotropin-releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studied by using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). Three SNPs were identified in CRHR1 gene and genotyped in the samples of patients diagnosed with major depression and matched controls. We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression.
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Zhu
authors.forename: Gaohua
authors.initials: G
authors.lastname: Wang
authors.forename: Zheman
authors.initials: Z
authors.lastname: Xiao
authors.forename: Huiling
authors.initials: H
authors.lastname: Wang
authors.forename: Jihua
authors.initials: J
authors.lastname: Tang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wang
authors.forename: Desheng
authors.initials: D
authors.lastname: Qiu
authors.forename: Wanhong
authors.initials: W
authors.lastname: Liu
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Cao
authors.forename: Wenxin
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D000099052:CRF Receptor, Type 1
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1