Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero.
BACKGROUND
Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early spontaneous pregnancy loss, ectopic gestation and infertility.


METHODS
A 34-year old woman with a 6-year history of primary infertility is presented. The patient underwent in vitro fertilization (IVF) treatment without success. To improve the quality of the endometrium following IVF treatment, E2 and progesterone supplementation was added to the usual therapeutic regimen. The pregnancy progressed uneventfully and a normal female was born.


CONCLUSIONS
This case indicates that the administration of E2 and progesterone in DES-exposed women might improve endometrium receptivity and consequently pregnancy outcome.
Loutradis
Dimitris
D
First Department of Obstetrics and Gynaecology, Athens University School of Medicine, Alexandra Hospital, Athens, Greece.
Stefanidis
Konstantinos
K
Kiapekou
Erasmia
E
Zapanti
Evangelia
E
Panitsa-Faflia
Chrisoula
C
Antsaklis
Aristidis
A
D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004717:Endometrium / Q000187:drug effects*; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000379:methods; D007246:Infertility / Q000139:chemically induced / Q000188:drug therapy; D008183:Luteal Phase / Q000187:drug effects*; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy*; D011374:Progesterone / Q000627:therapeutic use*
D011374:Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol