title: Computational approach to estimating the effects of blood properties on changes in intra-stent flow.
abstract: In this study various blood rheological assumptions are numerically investigated for the hemodynamic properties of intra-stent flow. Non-newtonian blood properties have never been implemented in blood coronary stented flow investigation, although its effects appear essential for a correct estimation and distribution of wall shear stress (WSS) exerted by the fluid on the internal vessel surface. Our numerical model is based on a full 3D stent mesh. Rigid wall and stationary inflow conditions are applied. Newtonian behavior, non-newtonian model based on Carreau-Yasuda relation and a characteristic newtonian value defined with flow representative parameters are introduced in this research. Non-newtonian flow generates an alteration of near wall viscosity norms compared to newtonian. Maximal WSS values are located in the center part of stent pattern structure and minimal values are focused on the proximal stent wire surface. A flow rate increase emphasizes fluid perturbations, and generates a WSS rise except for interstrut area. Nevertheless, a local quantitative analysis discloses an underestimation of WSS for modelisation using a newtonian blood flow, with clinical consequence of overestimate restenosis risk area. Characteristic viscosity introduction appears to present a useful option compared to rheological modelisation based on experimental data, with computer time gain and relevant results for quantitative and qualitative WSS determination.
authors.affiliation: Laboratoire d'Etudes Aérodynamiques, Université de Poitiers, Boulevard Marie et Pierre Curie, Teleport 2, BP 30179, 86962 Futuroscope, Chasseneuil Cedex, France. nicolas.benard@lea.univ-poitiers.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Benard
authors.forename: Robert
authors.initials: R
authors.lastname: Perrault
authors.forename: Damien
authors.initials: D
authors.lastname: Coisne
mesh_terms: D000818:Animals; D001158:Arteries / Q000503:physiopathology* / Q000601:surgery; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D004548:Elasticity; D019544:Equipment Failure Analysis / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D015607:Stents; D013314:Stress, Mechanical