title: Antiinflammatory activity of Polygala japonica extract.
abstract: The antiinflammatory activity of the aqueous extract of Polygala japonica (AEPJ) was investigated in mice and rats to find the pharmacological basis for its ethnomedical use. The extract produced a significant inhibition of peritoneal and cutaneous vascular permeability induced by acetic acid and histamine, respectively and ear swelling induced by picryl chloride in mice at the dose of 25.0 mg/kg. Moreover, the extract markedly inhibited footpad edema induced by histamine in rats, and decreased prostaglandin E(2) (PGE(2)) content in carrageenan-induced air-pouch at doses of 12.5 and 6.25 mg/kg respectively.
authors.affiliation: Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, P.R. China. junpingkou@163.com
authors.forename: Junping
authors.initials: J
authors.lastname: Kou
authors.forename: Minda
authors.initials: M
authors.lastname: Si
authors.forename: Guofei
authors.initials: G
authors.lastname: Dai
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Lin
authors.forename: Danni
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006632:Histamine; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010853:Picryl Chloride; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D031801:Polygala; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D006632:Histamine; D002351:Carrageenan; D010853:Picryl Chloride