title: Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
abstract: [reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Tsung-Hsiao
authors.initials: TH
authors.lastname: Kuo
authors.forename: Amooru G
authors.initials: AG
authors.lastname: Damu
authors.forename: Chung-Ren
authors.initials: CR
authors.lastname: Su
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Rexen
authors.initials: R
authors.lastname: Shu
authors.forename: Chou-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Tzu-Hsuan
authors.initials: TH
authors.lastname: Chen
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032321:Physalis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D013256:Steroids; C518941:physanolide A