Nephrotic syndrome and IgA nephropathy in polycystic kidney disease.
A 70-year-old man with polycystic kidney disease developed nephrotic syndrome, deteriorating to renal insufficiency. Histological examination revealed IgA nephropathy. With treatment of prednisolone, an angiotensin-converting enzyme inhibitor, and an angiotensin II receptor-blocker, his proteinuria markedly decreased and renal function was stabilized. This case supports the idea that renal biopsy is needed in patients with polycystic kidney disease with nephrotic-range proteinuria, for appropriate treatment and prevention of renal failure.
Hiura
Toru
T
Department of Internal Medicine, Nagaoka Red Cross Hospital, 297-1 Terajima-machi, Nagaoka, Niigata, 940-2085, Japan.
Yamazaki
Hajime
H
Saeki
Takako
T
Kawabe
Shotetsu
S
Ueno
Mitsuhiro
M
Nishi
Shinichi
S
Miyamura
Shoji
S
Gejyo
Fumitake
F
D000368:Aged; D001706:Biopsy; D004176:Dipyridamole / Q000627:therapeutic use; D005922:Glomerulonephritis, IGA / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D013841:Thiazepines / Q000627:therapeutic use
D013841:Thiazepines; D004176:Dipyridamole; C055603:temocapril hydrochloride; D011239:Prednisolone; D019808:Losartan