title: An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association.
abstract: The association of pleuropulmonary blastoma and cystic nephroma is an uncommon entity, with only 4 cases of such an association in the same patient described in English literature. We report a 5th histologically documented case in a 32-month-old boy. The boy underwent a pulmonary biopsy that showed a pleuropulmonary blastoma and a nephrectomy that showed a cystic nephroma. The pleuropulmonary mass showed an important regression with postbiopsy chemotherapy, allowing subsequent tumorectomy. To date very little is known about this rare entity, and a genetic link between these 2 tumors is hypothesized.
authors.affiliation: Department of Pathology, Hôpital Sainte-Justine, 3175 Chemin de la Côte-Ste-Catherine, Montréal, Québec H3T 1C5, Canada.
authors.forename: Dorotheé
authors.initials: D
authors.lastname: Bouron-Dal Soglio
authors.forename: Isabelle
authors.initials: I
authors.lastname: Harvey
authors.forename: Salam
authors.initials: S
authors.lastname: Yazbeck
authors.forename: Françoise
authors.initials: F
authors.lastname: Rypens
authors.forename: Luc L
authors.initials: LL
authors.lastname: Oligny
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fournet
mesh_terms: D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D009378:Neoplasms, Multiple Primary; D009392:Nephrectomy; D018201:Nephroma, Mesoblastic / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010997:Pleural Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018202:Pulmonary Blastoma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome