title: Orbitofrontal cortex hypometabolism, medication overuse headache, substance abuse and migraine: key pathophysiological issues.
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Gupta
mesh_terms: D000700:Analgesics / Q000009:adverse effects*; D005625:Frontal Lobe / Q000378:metabolism; D006261:Headache / Q000139:chemically induced*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D000700:Analgesics