Cellular responses to DNA damage: one signal, multiple choices.
DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.
Su
Tin Tin
TT
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. Tin.su@colorado.edu
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D016615:Telomere / Q000378:metabolism
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins