Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.
To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.
Archer
Hilary A
HA
Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Edison
Paul
P
Brooks
David J
DJ
Barnes
Jo
J
Frost
Chris
C
Yeatman
Tom
T
Fox
Nick C
NC
Rossor
Martin N
MN
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D000814:Aniline Compounds; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002250:Carbon Radioisotopes; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D013844:Thiazoles