title: Heterotopic inputs facilitate poststimulus afterdischarges of spinal WDR neurons in rats with chronic nerve constriction.
abstract: Heterotopic inputs activate spinal wide dynamic range (WDR) neurons in rats with chronic constriction of one sciatic nerve (CCI rats). A possible contribution from these inputs, to long-lasting afterdischarges (ADs) of noxious evoked responses, was investigated during reversible input blockade from adjacent saphenous nerve and contralateral peripheral nerve territories. The results show significant AD reduction or suppression, indicating that heterotopic afferences contribute to mechanisms underlying prolonged ADs.
authors.affiliation: Istituto di Bioimmagini e Fisiologia Molecolare, Italy. maria.luisa.Sotgui@ibfm.cnr.it
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Sotgiu
authors.forename: Maurizio
authors.initials: M
authors.lastname: Valente
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Caramenti
authors.forename: Gabriele Eliseo Mario
authors.initials: GE
authors.lastname: Biella
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D002908:Chronic Disease; D003250:Constriction; D004195:Disease Models, Animal; D007839:Functional Laterality; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009407:Nerve Block / Q000379:methods; D009474:Neurons / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D010812:Physical Stimulation / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D020426:Sciatic Neuropathy / Q000473:pathology / Q000503:physiopathology*; D013116:Spinal Cord / Q000473:pathology*; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine