Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk.
In breast milk and paired blood samples of nine HIV-1-infected lactating women, we undertook a study to detect a CD4 T-cell reservoir and to investigate its capacity to enter viral production after activation. Breast milk-infected CD4 T cells have a greater capacity to produce viral particles actively than blood CD4 T cells. This observation may explain the apparent paradox of a transmissible viral infection from a body fluid with a low viral concentration.
Becquart
Pierre
P
Research Unit 145 (UMR 145) Institute for Research and Development (IRD) and University of Montpellier 1, Montpellier, France.
Petitjean
Gaël
G
Tabaa
Yassine Al
YA
Valéa
Diane
D
Huguet
Marie-France
MF
Tuaillon
Edouard
E
Meda
Nicolas
N
Vendrell
Jean-Pierre
JP
Van de Perre
Philippe
P
D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008895:Milk, Human / Q000821:virology*; D014779:Virus Replication
D004279:DNA, Viral