title: Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori.
abstract: Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.
authors.affiliation: Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Colbeck
authors.forename: Lori M
authors.initials: LM
authors.lastname: Hansen
authors.forename: Julie M
authors.initials: JM
authors.lastname: Fong
authors.forename: Jay V
authors.initials: JV
authors.lastname: Solnick
mesh_terms: D018829:Adhesins, Bacterial / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D001422:Bacterial Adhesion / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D020869:Gene Expression Profiling; D014644:Genetic Variation; D005838:Genotype; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D018829:Adhesins, Bacterial; C400429:BabA protein, Helicobacter pylori; C451032:BabB protein, Helicobacter pylori; D001425:Bacterial Outer Membrane Proteins