Social behavior of the yeast protein-protein interaction network.
Protein-protein interaction networks are useful in contextual annotation of protein function and in general to achieve a system-level understanding of cellular behavior. This work reports on the social behavior of the yeast protein-protein interaction network and concludes that it is non-random. This work, while providing an analysis of organization of genes into functional societies, can potentially be useful in assessing the accuracy of contextual gene annotation based on such interaction networks.
Seshasayee
Aswin Sai Narain
AS
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK. aswin@ebi.ac.uk
D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005800:Genes, Fungal; D025941:Protein Interaction Mapping / Q000706:statistics & numerical data; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins