title: Synthesis and confirmation of structure for the gibberellin GA131 (18-hydroxy-GA4).
abstract: A general method for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA(4) (GA(131)) by means of a tandem process involving the conjugate addition of alkoxides to the alpha-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.
authors.affiliation: Research School of Chemistry, Australian National University, Canberra.
authors.forename: James R
authors.initials: JR
authors.lastname: Crow
authors.forename: Regan J
authors.initials: RJ
authors.lastname: Thomson
authors.forename: Lewis N
authors.initials: LN
authors.lastname: Mander
mesh_terms: D005875:Gibberellins / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D005875:Gibberellins