Psychosis and Wilson's disease: a case report.
In this article we present a case of a 26-year-old woman with clinical picture of acute psychosis, as the first and main manifestation of Wilson's disease, who developed abnormal involuntary choreoathetoid limb movements, few days after initiation of neuroleptic therapy. At the first movement neurological symptoms were misinterpreted as side effect of haloperidol, but consulted neurologist suggested additional diagnostic procedure which confirmed Wilson's disease. Psychiatric symptomatology and abnormal involuntary movements were the clinical manifestation of this disease, which improved with neuroleptic and chelating treatment. Interdisciplinary approach with good collaboration of psychiatrists and neurologists is crucial for Wilson's disease, because early diagnosis and treatment without delay is critical to the prognosis. This case serves as a reminder that involuntary movements can be side effect of antipsychotics but also the clinical manifestation of some illnesses, for example Wilson's, Huntington's and Fuhr's diseases.
Jukić
Ivana
I
Department of Internal medicine, Clinical Hospital Split, Croatia. ivjukic@yahoo.com
Titlić
Marina
M
Tonkić
Ante
A
Dodig
Goran
G
Rogosić
Veljko
V
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001264:Athetosis / Q000139:chemically induced / Q000175:diagnosis; D002614:Chelating Agents / Q000627:therapeutic use; D002819:Chorea / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D009460:Neurologic Examination; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology
D014150:Antipsychotic Agents; D002614:Chelating Agents; D006220:Haloperidol