Larvicidal diterpenes from Pterodon polygalaeflorus.
Ethanolic extract from seeds of Pterodon polygalaeflorus (Benth) has been shown to possess significant larvicidal activity against the mosquito Aedes aegypti. Bioassay-guided fractionation of the extract led to the isolation and characterization of the know diterpenoid furans 6alpha-hydroxyvouacapan-7beta,17beta-lactone (1), 6alpha,7beta-dihydroxyvouacapan- 17beta-oic acid (2) and methyl 6alpha,7beta-dihydroxyvouacapan-17beta-oate (3). The structures were established from infrared (IR), ultraviolet (UV), 1H-nuclear magnetic resonance (NMR), 13C-NMR, and mass spectral data: full NMR assignments are presented for compounds 1-3 and the diacetyl derivative of 3. Compounds 1-3 exhibited LC50 values of 50.08, 14.69, and 21.76 microg/mL against fourth-instar Aedes aegypti larvae.
De Omena
M C
MC
Departamento de Química, Universidade Federal de Alagoas, Maceió-AL, Brazil.
Bento
E S
ES
De Paula
J E
JE
Sant'Ana
A E G
AE
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D001681:Biological Assay; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010572:Pest Control, Biological / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
D004224:Diterpenes; D007306:Insecticides; D010936:Plant Extracts