Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.
A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
Paget
Steven D
SD
Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA.
Boggs
Christine M
CM
Foleno
Barbara D
BD
Goldschmidt
Raul M
RM
Hlasta
Dennis J
DJ
Weidner-Wells
Michele A
MA
Werblood
Harvey M
HM
Bush
Karen
K
Macielag
Mark J
MJ
D000081:Acetamides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects; D000069349:Linezolid; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011725:Pyridines; C030686:acetamide; D000069349:Linezolid; C023666:pyridine