title: IL-15/IL-15 receptor biology: a guided tour through an expanding universe.
abstract: The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.
authors.affiliation: Department of Immunology and Cell Biology, Research Center Borstel, D-23845 Borstel, Germany.
authors.forename: Vadim
authors.initials: V
authors.lastname: Budagian
authors.forename: Elena
authors.initials: E
authors.lastname: Bulanova
authors.forename: Ralf
authors.initials: R
authors.lastname: Paus
authors.forename: Silvia
authors.initials: S
authors.lastname: Bulfone-Paus
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D019409:Interleukin-15 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C508024:IL15RA protein, human; D019409:Interleukin-15; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2