[Soft tissue non lymphoid malignant round cell tumors in childhood and adolescence: morphological, immunophenotypic, and molecular features of diagnosis].
Soft tissue non lymphoid malignant round cell tumors observed in children and adolescents are rare and are very different from adult tumors. They are often undifferentiated and distinctive key morphologic features are often lacking, but, on the other hand, specific recurrent genetic alterations, mostly translocations, are distinctive. Immunohistochemical features are also important for the diagnosis, and there is sometimes a strong correlation between the presence or the absence of an immunoreactivity for a specific protein and the presence of a specific genetic alteration. Finally, careful morphologic histological examination and immunohistochemical features will lead to a diagnosis which will be often confirmed by cytogenetics (translocations) or molecular techniques (fusion transcripts, deletion, mutation).
Fréneaux
Paul
P
Service de Pathologie, Département de Biologie des Tumeurs, Institut Curie, 26 rue d'Ulm, 75005 Paris. paul.freneaux@curie.net
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D002648:Child; D002874:Chromosome Mapping; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology; D010235:Paraganglioma / Q000473:pathology; D018335:Rhabdoid Tumor / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000473:pathology; D012512:Sarcoma, Ewing / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*