title: Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: the partial lateral pharyngectomy.
abstract: BACKGROUND
  Although the lateral pharyngotomy is a well-known surgical procedure, to our knowledge, no published reports have described the results achieved with a lateral pharyngectomy approach in patients with isolated and previously untreated selected invasive squamous cell carcinoma of the lateral wall of the pyriform sinus.
  
  
  METHODS
  The medical files and operative charts of 30 patients with an isolated, and previously untreated, squamous cell carcinoma of the pyriform sinus, treated for cure by lateral partial pharyngectomy and primary closure, as well as postoperative radiotherapy (n = 22), and preoperative chemotherapy (n = 8), were retrospectively studied. Sixteen tumors were classified as T1 and 14 as T2. All patients but one were followed until death.
  
  
  RESULTS
  Three patients (9%) died in the immediate postoperative period (two from medical complications and one from a surgery-related complication). Overall, 29 patients died, resulting in a 77.7%, 40%, 23.3%, and 15% 1-, 3-, 5- and 10-year Kaplan-Meier actuarial survival estimate, respectively. Only one patient had a serious postoperative complication develop. All patients were decannulated. No patients required a gastrostomy and/or completion total laryngectomy for functional reasons. Local recurrence occurred in four patients (13%). The 3-and 5-year Kaplan-Meier actuarial local control estimates were 88.5% and 79.6%, respectively. The use of a platin-based induction chemotherapy (p = .05) regimen was the only variable that was significantly statistically related to local recurrence. Overall, a 93.3% laryngeal preservation rate was achieved.
  
  
  CONCLUSIONS
  Partial pharyngectomy by means of the lateral pharyngotomy combined with postoperative radiation therapy is an efficient and function-sparing approach to control selected invasive squamous cell carcinomas of the lateral wall of the pyriform sinus.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Université Paris V, 20-40, rue Leblanc, 75015 Paris, France.
authors.forename: F Christopher
authors.initials: FC
authors.lastname: Holsinger
authors.forename: Mehdi
authors.initials: M
authors.lastname: Motamed
authors.forename: Dominique
authors.initials: D
authors.lastname: Garcia
authors.forename: Daniel
authors.initials: D
authors.lastname: Brasnu
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ménard
authors.forename: Ollivier
authors.initials: O
authors.lastname: Laccourreye
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D002423:Cause of Death; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D010611:Pharyngectomy; D010614:Pharynx / Q000601:surgery*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies