Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings.
Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.
Michopoulos
I
I
2nd Department of Psychiatry, Athens University Medical School, Attikon General Hospital, 1 Rimini Street, 124 62 Athens, Greece. panpsyclin@attikonhospital.gr
Zervas
I M
IM
Papakosta
V M
VM
Tsaltas
E
E
Papageorgiou
C
C
Manessi
T
T
Papakostas
Y G
YG
Lykouras
L
L
Soldatos
C R
CR
D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003710:Demography; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires