title: Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance.
abstract: The incidence of FLT3 mutations (internal tandem duplication and Asp835) was investigated in bone marrow samples from 97 patients with myelodysplastic syndrome [(MDS); excluding cases with refractory anaemia with excess blasts in transformation] at the time of diagnosis and several time points thereafter. Three patients had FLT3 mutations at presentation. Forty-two patients progressed to acute myeloid leukaemia (AML), including the three patients with FLT3 mutations at MDS diagnosis. Three additional patients acquired FLT3 mutations and progressed to AML in 1 month. FLT3 mutations seem to be a critical additional genetic event that transforms a minority of MDS patients to AML.
authors.affiliation: First Department of Propaedeutic Medicine, Laikon Hospital, University of Athens, Athens, Greece. george_i_georgiou@hotmail.com
authors.forename: Georgios
authors.initials: G
authors.lastname: Georgiou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Karali
authors.forename: Christina
authors.initials: C
authors.lastname: Zouvelou
authors.forename: Elias
authors.initials: E
authors.lastname: Kyriakou
authors.forename: Maria
authors.initials: M
authors.lastname: Dimou
authors.forename: Stamatis
authors.initials: S
authors.lastname: Chrisochoou
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Greka
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Dufexis
authors.forename: Elisavet
authors.initials: E
authors.lastname: Vervesou
authors.forename: Evaggelia
authors.initials: E
authors.lastname: Dimitriadou
authors.forename: Anna
authors.initials: A
authors.lastname: Efthymiou
authors.forename: Loizos
authors.initials: L
authors.lastname: Petrikkos
authors.forename: Katerina
authors.initials: K
authors.lastname: Dima
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Lilakos
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Panayiotidis
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D016016:Proportional Hazards Models; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018709:Statistics, Nonparametric; D015996:Survival Rate; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3