title: Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.
abstract: A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. bblass2@fuse.net
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Blass
authors.forename: Keith
authors.initials: K
authors.lastname: Coburn
authors.forename: Wenlin
authors.initials: W
authors.lastname: Lee
authors.forename: Neil
authors.initials: N
authors.lastname: Fairweather
authors.forename: Andrew
authors.initials: A
authors.lastname: Fluxe
authors.forename: Shengde
authors.initials: S
authors.lastname: Wu
authors.forename: John M
authors.initials: JM
authors.lastname: Janusz
authors.forename: Michael
authors.initials: M
authors.lastname: Murawsky
authors.forename: Gina M
authors.initials: GM
authors.lastname: Fadayel
authors.forename: Bin
authors.initials: B
authors.lastname: Fang
authors.forename: Michelle
authors.initials: M
authors.lastname: Hare
authors.forename: Jim
authors.initials: J
authors.lastname: Ridgeway
authors.forename: Ron
authors.initials: R
authors.lastname: White
authors.forename: Chris
authors.initials: C
authors.lastname: Jackson
authors.forename: Laurent
authors.initials: L
authors.lastname: Djandjighian
authors.forename: Richard
authors.initials: R
authors.lastname: Hedges
authors.forename: Fred C
authors.initials: FC
authors.lastname: Wireko
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Ritter
mesh_terms: D001281:Atrial Fibrillation / Q000378:metabolism*; D002460:Cell Line; D018360:Crystallography, X-Ray; D006801:Humans; D051666:Kv1.5 Potassium Channel / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008697:Methane / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers; D008697:Methane