title: Improving the consistency of ovarian stimulation: follitropin alfa filled-by-mass.
abstract: In their quest for a child, infertile couples embark on a journey that is full of expectations and hopes. Over recent years, treatment procedures for assisted conception have become safer and more efficient. However, couples undergoing treatment can still experience some degree of emotional stress due to disappointment if pregnancy is not achieved, or if treatment cycles may have to be cancelled due to a low- or hyper-response. Strategies aimed at minimizing the variability of ovarian response or overall treatment outcome can be expected to significantly reduce this emotional stress. New developments have led to the production of follitropin alfa filled by mass. This is a highly consistent FSH preparation improving the consistency of ovarian response and reducing the risk of cycle cancellation. The impact of this new FSH preparation for assisted reproduction treatments is discussed in this review.
authors.affiliation: Fertility Centre Scandinavia, Carlanders Hospital, Box 5918, S-401 29 Gothenburg, Sweden. matts.wikland@fcivf.com
authors.forename: Matts
authors.initials: M
authors.lastname: Wikland
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Hugues
authors.forename: Colin
authors.initials: C
authors.lastname: Howles
mesh_terms: D005260:Female; D005307:Fertilization in Vitro; D015292:Glycoprotein Hormones, alpha Subunit / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010062:Ovulation Induction / Q000592:standards*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D027724:Reproductive Techniques, Assisted / Q000592:standards
chemical_list: D015292:Glycoprotein Hormones, alpha Subunit