Prospective determination of plasma imipenem concentrations in critically ill children.
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.
Giannoni
Eric
E
Department of Pediatrics, CHUV, CH-1011 Lausanne, Switzerland.
Moreillon
Philippe
P
Cotting
Jacques
J
Moessinger
Adrien
A
Bille
Jacques
J
Décosterd
Laurent
L
Zanetti
Giorgio
G
Majcherczyk
Paul
P
Bugnon
Denis
D
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D015377:Cilastatin / Q000008:administration & dosage; D000077728:Cilastatin, Imipenem Drug Combination; D016638:Critical Illness; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination