title: UGT1A1 promoter polymorphism as a predisposing factor of hyperbilirubinaemia in neonates with acute pyelonephritis.
abstract: We describe 4 jaundiced neonates with acute pyelonephritis of whom family history was positive for or pointed to Gilbert's syndrome (GS). Uridine diphosphate glucuronosyltransferase 1A1 (UGT-1A1), (TA)7 polymorphism, associated with GS was found in these neonates. We suggest that extended (TA)7 promoter, acting as a predisposing factor, contributes substantially to hyperbilirubinaemia seen in a number of neonates with urinary tract infections (UTIs).
authors.affiliation: Third Department of Paediatrics, Attikon University Hospital, Athens, Greece. afretz@med.uoa.gr
authors.forename: Andrew
authors.initials: A
authors.lastname: Fretzayas
authors.forename: Sofia
authors.initials: S
authors.lastname: Kitsiou
authors.forename: Aspasia
authors.initials: A
authors.lastname: Tsezou
authors.forename: Augustina
authors.initials: A
authors.lastname: Alexaki
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Nicolaidou
mesh_terms: D005260:Female; D005878:Gilbert Disease / Q000201:enzymology / Q000235:genetics*; D014453:Glucuronosyltransferase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000201:enzymology / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D011704:Pyelonephritis / Q000235:genetics*; D000099148:UGT1A1 Enzyme
chemical_list: D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme