title: Severe chronic asthma.
abstract: Persistent childhood asthma is more common in females with atopy with an early onset and may result in significant impairment of lung function. Pathological changes in severe chronic asthma in childhood are only partially defined and correlation between pathology, response to treatment and persistence is imprecise. Failure to respond to usual therapies requires careful consideration of differential diagnosis, type of inflammation present, compliance with therapy, and continuing monitoring and re-assessment.
authors.affiliation: Firestone Institute for Respiratory Health, St. Joseph's Hospital-McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6. searsm@mcmaster.ca
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Sears
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy*; D002648:Child; D002908:Chronic Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D020024:Leukotriene Antagonists