Microbial hydrolysis of acetylated nucleosides.
Enzymatic hydrolysis of acetylated nucleosides using microbial whole cells has been carried out for the first time. Unlike Candida antarctica B lipase-catalysed alcoholysis, none of the tested microorganisms displayed a common deacetylation profile. Depending on the substrate and the biocatalyst used, 5'-selective deprotection or mixtures of mono O-acetylated products were obtained.
Panero
Julieta
J
Universidad Nacional de Quilmes, RS Peña 352 (1876), Bernal, Buenos Aires, Argentina.
Trelles
Jorge
J
Rodano
Valeria
V
Montserrat
Javier M
JM
Iglesias
Luis E
LE
Lewkowicz
Elizabeth S
ES
Iribarren
Adolfo M
AM
D000107:Acetylation; D001420:Bacteria, Aerobic / Q000145:classification / Q000378:metabolism*; D001711:Biotransformation; D002384:Catalysis; D006868:Hydrolysis; D009705:Nucleosides / Q000378:metabolism*; D013045:Species Specificity
D009705:Nucleosides