Bioinformatics and cancer: an essential alliance.
Modern research in cancer has been revolutionized by the introduction of new high-throughput methodologies such as DNA microarrays. Keeping the pace with these technologies, the bioinformatics offer new solutions for data analysis and, what is more important, it permits to formulate a new class of hypothesis inspired in systems biology, more oriented to blocks of functionally-related genes. Although software implementations for this new methodologies is new there are some options already available. Bioinformatic solutions for other high-throughput techniques such as array-CGH of large-scale genotyping is also revised.
Dopazo
Joaquín
J
Department of Bioinformatics, Centro de Investigación Príncipe Felipe, Valencia, Spain. jdopazo@cipf.es
D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D019295:Computational Biology; D004273:DNA, Neoplasm / Q000235:genetics; D016208:Databases, Factual; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics / Q000379:methods*; D006801:Humans; D020407:Internet; D009369:Neoplasms / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D012984:Software
D004273:DNA, Neoplasm