Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma.
OBJECTIVE
The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG).


METHODS
Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis.


RESULTS
Bimatoprost 0.03% significantly reduced mean IOP from 15.1 +/- 3.8 mmHg at baseline to 12.0 +/- 2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment.


CONCLUSIONS
Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.
Chen
Mei-Ju
MJ
Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan. mj_chen@vghtpe.gov.tw
Cheng
Ching-Yu
CY
Chen
Yen-Cheng
YC
Chou
Ching-Kuang
CK
Hsu
Wen-Ming
WM
D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000627:therapeutic use*; D000069580:Bimatoprost; D002940:Circadian Rhythm; D003008:Cloprostenol / Q000031:analogs & derivatives; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008055:Lipids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000577:Amides; D008055:Lipids; D003008:Cloprostenol; D000069580:Bimatoprost