title: Dissociation between the cognitive process and the phenomenological experience of TOT: effect of the anxiolytic drug lorazepam on TOT states.
abstract: TOT states may be viewed as a temporary and reversible microamnesia. We investigated the effects of lorazepam on TOT states in response to general knowledge questions. The lorazepam participants produced more commission errors and more TOTs following commission errors than the placebo participants (although the rates did not change). The resolution of the TOTs was unimpaired by the drug. Neither feeling-of-knowing accuracy nor recognition were affected by lorazepam. The higher level of incorrect recalls produced by lorazepam participants may be due to the fact that they were more frequently temporarily unable to access a known item. For some of these items, the awareness of the retrieval failure resulted in a commission TOT (phenonemological TOT after a commission error). The resolution of the TOT conflict is discussed in the light of the anxiolytic and anticonflict effects of lorazepam. The data are discussed in terms of contemporary theories of TOTs and the effects that benzodiazepines have on semantic memory.
authors.affiliation: INSERM Unité 405, Strasbourg, France. bacon@alsace.u-strasbg.fr
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bacon
authors.forename: Bennett L
authors.initials: BL
authors.lastname: Schwartz
authors.forename: Laurence
authors.initials: L
authors.lastname: Paire-Ficout
authors.forename: Marie
authors.initials: M
authors.lastname: Izaute
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001364:Awareness; D003071:Cognition / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D008568:Memory / Q000187:drug effects; D011939:Mental Recall; D008960:Models, Psychological; D011578:Psycholinguistics; D021641:Recognition, Psychology; D012660:Semantics
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam