Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats.
In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
Marion
Rachel
R
Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen, France.
Baishanbo
Asiya
A
Gargala
Gilles
G
François
Arnaud
A
Ducrotté
Philippe
P
Duclos
Celia
C
Fioramonti
Jean
J
Ballet
Jean Jacques
JJ
Favennec
Loïc
L
D000818:Animals; D000831:Animals, Newborn; D003457:Cryptosporidiosis / Q000276:immunology* / Q000503:physiopathology; D016785:Cryptosporidium parvum; D005260:Female; D006967:Hypersensitivity / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D007583:Jejunum / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley