Renal preglomerular arterial-venous O2 shunting is a structural anti-oxidant defence mechanism of the renal cortex.
1. High blood flow to the kidney facilitates a high glomerular filtration rate, but total renal O2 delivery greatly exceeds renal metabolic requirements. However, tissue Po2 in much of the renal cortex is lower than may be expected, being similar to that of other organs in which perfusion is closely matched to metabolic demand. 2. The lower than expected renal cortical Po2 is now attributed largely to diffusional shunting of as much as 50% of inflowing O2 from blood within preglomerular arterial vessels to post-glomerular venous vessels. However, the functional significance of this O2 shunting remains unclear. Indeed, this mechanism may appear maladaptive, given the kidney's susceptibility to hypoxic insults. 3. We hypothesize that renal preglomerular arterial-venous O2 shunting acts to protect the kidney from the potentially damaging consequences of tissue hyperoxia. The diffusion of O2 from arteries to veins within the kidney acts to reduce the O2 content of the blood before it is distributed to the renal microcirculation. Because high tissue Po2 may increase the production of reactive oxygen species, we suggest that renal arterial-venous O2 shunting may provide a physiological benefit to the organism by limiting O2 delivery to renal tissue, thereby reducing the risk of cellular oxidation.
O'Connor
Paul M
PM
Department of Physiology, Monash University, Melbourne, Victoria, Australia. POconnor@mail.phys.mcw.edu
Anderson
Warwick P
WP
Kett
Michelle M
MM
Evans
Roger G
RG
D000222:Adaptation, Physiological; D000818:Animals; D005075:Biological Evolution; D004058:Diffusion; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D007672:Kidney Cortex / Q000098:blood supply / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000098:blood supply / Q000378:metabolism*; D018384:Oxidative Stress; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010313:Partial Pressure; D012079:Renal Circulation
D005609:Free Radicals; D010100:Oxygen