Bactericidal activity of different oxovanadium(IV) complexes with Schiff bases and application of chelation theory.
Oxovanadium(IV) complexes have been synthesized and characterized the general composition [VOL(A)], where H2L = salicylidene-o-aminothiophenol A1 = bis(benzylidene)ethylenediamine, A2 = bis(acetophenone)ethylenediamine, A3 = 2,2'-bipyridylamine, A4 = bis(benzylidene) - 1,8-diaminonaphthalene, A5 = thiophene-o-carboxaldeneaniline and A6 = thiophene-o-carboxaldene-p-anisidine. Spectral studies indicate that the oxovanadium(IV) complexes assume a six-coordinate octahedral geometry. The antibacterial activities of the complexes against Salmonella typhi, Escherichia coli and Serratia mercescens are higher as compared to the free ligands, vanadyl sulphate, and the control (DMSO) but of moderate activity as compared to the standard drug (tetracycline).
Panchal
Pragnesh K
PK
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar-388 120, Gujarat, India.
Parekh
Hitesh M
HM
Pansuriya
Pramod B
PB
Patel
Mohan N
MN
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D046590:Spectroscopy, Electron Energy-Loss; D017550:Spectroscopy, Fourier Transform Infrared; D014638:Vanadates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D008024:Ligands; D012545:Schiff Bases; C075743:oxovanadium IV; D014638:Vanadates