title: Structural and functional salivary disorders in type 2 diabetic patients.
abstract: Diabetes mellitus type 2 is the most common metabolic disorder and it causes an important morbimortality. The structural modifications in the parotid gland (sialosis) had already been described in these patients and could result in variations in the salivary composition, as well as an increase in periodontal and dental pathology.
  
  
  OBJECTIVE
  To compare the biochemical findings in the saliva and to correlate these biochemical disturbances with the morphologic findings previously described.
  
  
  METHODS
  Clinical information were gathered about 33 patients, 17 had type 2 diabetes. Samples of whole saliva were obtained for biochemical analysis and serum samples to determine metabolic control.
  
  
  RESULTS
  In the diabetics saliva we found urea and total proteins increased and reduced levels of microalbumina. Salivary glucose was only augmented in patients with poor metabolic control. Clinical symptoms of xerostomia were present in 76,4% and dental and periodontal disease in 100%. The parotid gland was characterised by the presence of small acini, lipid intracytoplasmic droplets, as well as adipose stroma infiltration. The acinar cytoqueratins expression was heterogeneous and very positive in the hyperplasic ducts.
  
  
  CONCLUSIONS
  These biochemical disorders in the saliva of the type 2 diabetic patients would be related with the structural changes previously observed in parotid glands.
authors.affiliation: Catedrática de Histología, Dpto de Patología, Facultad de Medicina y Odontología, Universidad de Valencia, España. carmen.carda@uv.es
authors.forename: Carmen
authors.initials: C
authors.lastname: Carda
authors.forename: Nezly
authors.initials: N
authors.lastname: Mosquera-Lloreda
authors.forename: Lucas
authors.initials: L
authors.lastname: Salom
authors.forename: Maria Elsa
authors.initials: ME
authors.lastname: Gomez de Ferraris
authors.forename: Amando
authors.initials: A
authors.lastname: Peydró
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism*