[Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats].
OBJECTIVE
To study the effectiveness of the lidocaine test in evaluating the liver reserve of rats with experimental liver injury in different phases.


METHODS
40 healthy male Wistar rats were divided randomly into experimental and control groups. Rats of the experimental group received subcutaneous CCl4 in oil injection, and rats of the control group received saline injections. Monoethylglycinexylidide (MEGX) test, common hepatic function tests and histological examination of the livers were performed on all the rats.


RESULTS
With the development of the severity in liver injury, the concentrations of the serum MEGX in lidocaine test decreased gradually, which were consistent with liver histological changes. However, the results from the common liver function tests were all abnormal in the experimental group and were not consistent with the liver histological changes.


CONCLUSIONS
The results obtained from the MEGX test are more agreeable to liver histological changes than those from common liver function tests. The results from the MEGX test can represent liver histological changes concisely.
Wang
Zhen-xia
ZX
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Rui-ming
RM
Yan
Lü-nan
LN
Wang
Wen-tao
WT
Jia
Qian-bin
QB
D000818:Animals; D002251:Carbon Tetrachloride; D002252:Carbon Tetrachloride Poisoning; D008012:Lidocaine / Q000031:analogs & derivatives; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D008012:Lidocaine; D002251:Carbon Tetrachloride; C001173:monoethylglycinexylidide