Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines.
A new subfamily of chemokine receptors is emerging that do not signal along classical G-protein-mediated pathways. Instead, these "silent" receptors efficiently internalize their cognate chemokine ligands, hence their suggested name, "chemokine interceptors", for internalizing receptors. Two of these interceptors, DARC and D6, possess intriguing patterns of tissue expression and are believed to be involved in controlling the local levels of proinflammatory chemokines. In this issue of the European Journal of Immunology, the biochemical properties of a third silent chemokine receptor, CCX-CKR, have been characterized and it is suggested that it may act as a scavenger for homeostatic chemokines, pointing to a broad and significant role for this group of chemokine binding molecules in chemokine biology.
Haraldsen
Guttorm
G
Department of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway.
Rot
Antal
A
D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D004375:Duffy Blood-Group System / Q000502:physiology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*; D000097628:Chemokine Receptor D6
D018925:Chemokines; D004375:Duffy Blood-Group System; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine; D000097628:Chemokine Receptor D6; C473745:ACKR1 protein, human