title: Influence of hematocrit and pump prime on cerebral oxygen saturation in on-pump coronary revascularization.
abstract: BACKGROUND
  The couplings between cerebral oxygenation (rSO2), on-pump hematocrit and circuit prime are explored in this study.
  
  
  METHODS
  Thirty-eight consecutive patients undergoing coronary revascularization with cardiopulmonary bypass (CPB) were matched on preoperative hematocrit < 40% and > 40% (n = 16). Similarly, six blood prime patients were matched with six crystalloid prime patients. Hematocrit and rSO2 levels were then compared on CPB.
  
  
  RESULTS
  The preoperative hematocrit > 40% group retained higher levels on pump run (p < 0.01) and significantly higher rSO2 prior to CPB (64.8 +/- 9.6 versus 73.2 +/- 7.3), and on and off CPB (61.1 +/- 8.8 versus 67.4 +/- 6.4). Blood priming increased absolute rSO2 (2.3 +/- 6.3 versus -10.9 +/- 5.9) and % rSO2 (4.7 +/- 11.8 versus -14.2 +/- 7.4%) in the low hematocrit group.
  
  
  CONCLUSIONS
  Blood primes are instrumental in high-risk and low preoperative hematocrit patients in preventing cerebral oxygen desaturation during initiation and maintenance of CPB.
authors.affiliation: Portsmouth Regional Hospital, NH, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: McCusker
authors.forename: Anthony
authors.initials: A
authors.lastname: Chalafant
authors.forename: Gordon
authors.initials: G
authors.lastname: de Foe
authors.forename: Serdar
authors.initials: S
authors.lastname: Gunaydin
authors.forename: Venkataramana
authors.initials: V
authors.lastname: Vijay
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D002318:Cardiovascular Diseases / Q000097:blood / Q000601:surgery; D002560:Cerebrovascular Circulation; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D012189:Retrospective Studies
chemical_list: D010100:Oxygen