Possible associations between successful aging and polymorphic markers in the Werner gene region.
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5' flanking region and 5' UTR to be significantly associated with the cognitive functioning level in old age.
Sild
Mari
M
Institute of Human Genetics, University of Aarhus, Denmark. sild@humgen.au.dk
Koca
Cemile
C
Bendixen
Mette H
MH
Frederiksen
Henrik
H
McGue
Matt
M
Kølvraa
Steen
S
Christensen
Kaare
K
Nexø
Bjørn
B
D024506:5' Flanking Region; D020121:5' Untranslated Regions; D000375:Aging; D015415:Biomarkers / Q000032:analysis; D004265:DNA Helicases / Q000235:genetics*; D030541:Databases, Genetic; D005090:Exodeoxyribonucleases; D006801:Humans; D008137:Longitudinal Studies; D009154:Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D053484:RecQ Helicases; D014427:Twins / Q000235:genetics; D014898:Werner Syndrome / Q000235:genetics*; D000071657:Werner Syndrome Helicase
D020121:5' Untranslated Regions; D015415:Biomarkers; D005090:Exodeoxyribonucleases; D004265:DNA Helicases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase