title: Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX).
abstract: A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH(3)COO](-), m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 --> 147 and m/z 355 --> 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 microg/L and good linearity was achieved in the range 5-500 microg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.
authors.affiliation: The Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409-1163, USA. xiaoping.pan@tiehh.ttu.edu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Baohong
authors.initials: B
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Tian
authors.forename: Lindsey E
authors.initials: LE
authors.lastname: Jones
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Todd A
authors.initials: TA
authors.lastname: Anderson
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: George P
authors.initials: GP
authors.lastname: Cobb
mesh_terms: D001392:Azocines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods; D053834:Explosive Agents / Q000032:analysis*; D006573:Heterocyclic Compounds, 1-Ring / Q000032:analysis*; D012680:Sensitivity and Specificity; D012987:Soil / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D001392:Azocines; D053834:Explosive Agents; D006573:Heterocyclic Compounds, 1-Ring; D012987:Soil; C007950:octogen