title: In vitro assessment of a gel base containing 2% chlorhexidine as a sodium perborate's vehicle for intracoronal bleaching of discolored teeth.
abstract: The purpose of this study was to assess a gel base containing 2% chlorhexidine (CHX) as a vehicle to be mixed with sodium perborate for intracoronal bleaching of discolored teeth, comparing its bleaching efficacy to sodium perborate mixed with other vehicles; 37% carbamide peroxide and 30% hydrogen peroxide. There were 110 fresh bovine incisors artificially stained using whole blood. The samples were divided into 11 groups and the intracoronal bleaching was performed using the "walking bleach technique". The bleaching agents were replaced three times at 7-day intervals. Using digital photos and a shade guide created for bovine teeth, the samples were evaluated at day 0, 7, 14, 21, and 28. On evaluation day, the photos were examined by three endodontists giving scores from 1 to 5 based on the shade guide created. Data were analyzed statistically by Kruskall-Wallis test. After 28 days, all evaluated teeth received scores that were statistically similar. Groups that used sodium perborate and a liquid vehicle bleached faster than those that used a gel based vehicle. The CHX gel allowed dissociation for the bleaching agent. The 2% CHX gel exhibited a good potential for use as a vehicle for sodium perborate or as a complement for carbamide peroxide.
authors.affiliation: Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil. danifop@hotmail.com
authors.forename: Daniel Pinto de
authors.initials: DP
authors.lastname: Oliveira
authors.forename: Brenda Paula Figueiredo de Almeida
authors.initials: BP
authors.lastname: Gomes
authors.forename: Alexandre Augusto
authors.initials: AA
authors.lastname: Zaia
authors.forename: Francisco José de
authors.initials: FJ
authors.lastname: Souza-Filho
authors.forename: Caio Cezar Randi
authors.initials: CC
authors.lastname: Ferraz
mesh_terms: D000818:Animals; D001881:Borates / Q000008:administration & dosage*; D000077463:Carbamide Peroxide; D002417:Cattle; D002710:Chlorhexidine; D003763:Dental Leakage / Q000517:prevention & control; D004338:Drug Combinations; D005782:Gels; D016877:Oxidants / Q000008:administration & dosage; D010545:Peroxides / Q000008:administration & dosage; D014677:Pharmaceutical Vehicles; D018709:Statistics, Nonparametric; D014073:Tooth Bleaching / Q000379:methods*; D014075:Tooth Discoloration / Q000188:drug therapy*; D019553:Tooth, Nonvital; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D001881:Borates; D004338:Drug Combinations; D005782:Gels; D016877:Oxidants; D010545:Peroxides; D014677:Pharmaceutical Vehicles; D000077463:Carbamide Peroxide; D014508:Urea; D002710:Chlorhexidine; C027707:sodium perborate