title: Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
abstract: Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.
authors.affiliation: Human Disease and Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire ST4 7PX, United Kingdom.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Rukin
authors.forename: Christopher
authors.initials: C
authors.lastname: Luscombe
authors.forename: Sam
authors.initials: S
authors.lastname: Moon
authors.forename: Dhaval
authors.initials: D
authors.lastname: Bodiwala
authors.forename: Samson
authors.initials: S
authors.lastname: Liu
authors.forename: Mark F
authors.initials: MF
authors.lastname: Saxby
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Fryer
authors.forename: Julie
authors.initials: J
authors.lastname: Alldersea
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hoban
authors.forename: Richard C
authors.initials: RC
authors.lastname: Strange
mesh_terms: D001483:Base Sequence; D017931:DNA Primers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D014466:Ultraviolet Rays
chemical_list: D017931:DNA Primers; D018167:Receptors, Calcitriol