Novel peroxidase mimics: mu-Aqua manganese-Schiff base dimers.
The interaction of manganese(II) carboxylate salts [Mn(O(2)CR)(2), where R=ethane, pentane] with H(2)L(1) [N,N'-bis(3-methoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] and H(2)L(2) [N,N'-bis(3-ethoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] was studied. MnL(1)(O(2)CEt)(H(2)O) (1), MnL(1)(O(2)CPe(n))(H(2)O) (2), MnL(2)(O(2)CEt)(H(2)O)(2) (3) and MnL(2)(O(2)CPe(n))(H(2)O)(2) (4) were isolated and thoroughly characterised by elemental analysis, FAB mass spectrometry, infrared and (1)H NMR spectroscopy, magnetic susceptibility measurements, molar conductivities, and cyclic and normal pulse voltammetry. Compounds 1 and 2 were crystallographically characterised revealing a tetragonally elongated octahedral geometry for the manganese coordination sphere and also a dimeric nature through mu-aqua bridges. Complexes 1-4 behave as efficient peroxidase mimics in the presence of the water-soluble trap ABTS, probably due to their ease to coordinate the substrate molecule. A correlation between rhombicity of the complexes and peroxidase activity has also been established.
Bermejo
Manuel R
MR
Departamento de Química Inorgánica, Facultade de Química, Universidade de Santiago de Compostela, Avda. das Ciencias, s/n, Santiago de Compostela, Galicia E-15782, Spain. qimb45@usc.es
Fernández
M Isabel
MI
González-Noya
Ana M
AM
Maneiro
Marcelino
M
Pedrido
Rosa
R
Rodríguez
M Jesús
MJ
García-Monteagudo
Juan C
JC
Donnadieu
Bruno
B
D002264:Carboxylic Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D019281:Dimerization; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D017895:Manganese Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009195:Peroxidase / Q000737:chemistry*; D010655:Phenylenediamines / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*
D002264:Carboxylic Acids; D017895:Manganese Compounds; D010655:Phenylenediamines; D012545:Schiff Bases; D009195:Peroxidase