Prognosis of lupus membranous nephropathy in children.
The occurrence of membranous nephropathy in pediatric series of systemic lupus erythematosus has been reported only rarely, probably due to a very low frequency. One hundred fifty-four children who were seen in 100 French pediatric centers between January 2002 and April 2005 were included. Fifteen (12 girls and three boys) out of the 81 (18.5 %) children with renal involvement presented histological features of membranous nephropathy. Their ages ranged from six to 15 years old (mean=11.3) at the age of SLE diagnosis and 8/15 children were of African origin. Isolated membranous nephropathy was observed in nine patients, of whom five patients displayed a complete recovery following immunosuppressive treatment. Associated proliferative lesions were observed on the first kidney specimen in two patients and in a further renal biopsy in four other patients, leading to a less favorable course of lupus nephropathy.
Nathanson
Sylvie
S
Pediatric Unit, Hôpital Mignot, 177 rue de Versailles, 78150, le Chesnay, France.
Salomon
Rémi
R
Ranchin
Bruno
B
Macher
Marie-Alice
MA
Lavocat
Marie-Pierre
MP
Krier
Marie-Jeanne
MJ
Baudouin
Véronique
V
Azéma
Christine
C
Bader-Meunier
Brigitte
B
Deschênes
Georges
G
D000293:Adolescent; D002648:Child; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D011379:Prognosis