title: Microbial hydrolysis of acetylated nucleosides.
abstract: Enzymatic hydrolysis of acetylated nucleosides using microbial whole cells has been carried out for the first time. Unlike Candida antarctica B lipase-catalysed alcoholysis, none of the tested microorganisms displayed a common deacetylation profile. Depending on the substrate and the biocatalyst used, 5'-selective deprotection or mixtures of mono O-acetylated products were obtained.
authors.affiliation: Universidad Nacional de Quilmes, RS Peña 352 (1876), Bernal, Buenos Aires, Argentina.
authors.forename: Julieta
authors.initials: J
authors.lastname: Panero
authors.forename: Jorge
authors.initials: J
authors.lastname: Trelles
authors.forename: Valeria
authors.initials: V
authors.lastname: Rodano
authors.forename: Javier M
authors.initials: JM
authors.lastname: Montserrat
authors.forename: Luis E
authors.initials: LE
authors.lastname: Iglesias
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Lewkowicz
authors.forename: Adolfo M
authors.initials: AM
authors.lastname: Iribarren
mesh_terms: D000107:Acetylation; D001420:Bacteria, Aerobic / Q000145:classification / Q000378:metabolism*; D001711:Biotransformation; D002384:Catalysis; D006868:Hydrolysis; D009705:Nucleosides / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D009705:Nucleosides