title: Intramolecular asymmetric Heck reactions: evidence for dynamic kinetic resolution effects.
abstract: [reaction: see text] Enantioselectivity of the cyclization of 1 varies at different stages in the reaction. X-ray crystallography has shown that 1 exists as enantiomerically pure (M) and (P) chiral helical structures defined by the relative orientations of the arene, amide, and alkene. The relative rates of interconversion of the rotamers of 1 have been established, leading to mechanistic proposals to account for the variation of ee based on kinetic resolution effects.
authors.affiliation: Wolfson Materials and Catalysis Centre, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK.
authors.forename: Michael C
authors.initials: MC
authors.lastname: McDermott
authors.forename: G Richard
authors.initials: GR
authors.lastname: Stephenson
authors.forename: David L
authors.initials: DL
authors.lastname: Hughes
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Walkington