A new copolymer membrane controlling clonidine linear release in a transdermal drug delivery system.
A new type of copolymer membranes was prepared through photosynthesis of mixtures of three different monomers. The membranes present a linear permeation property in clonidine transdermal drug delivery system. Monomers used in the photosynthesis were 2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate and sec-butyl tiglate. Permeation property of the membranes with different monomer ratios and thickness were investigated. When clonidine concentrations were in 3.0 - 5.0 mg/ml range, membranes showed near zero order permeation rates. An optimized membrane was characterized by FTIR, DSC and SEM.
Zhan
Xiaoping
X
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.
Tang
Guochun
G
Chen
Sijing
S
Mao
Zhenmin
Z
D000179:Acrylates / Q000737:chemistry / Q000528:radiation effects; D000279:Administration, Cutaneous; D002152:Calorimetry, Differential Scanning; D003000:Clonidine / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry / Q000528:radiation effects; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D010777:Photochemistry; D011108:Polymers / Q000138:chemical synthesis*; D017550:Spectroscopy, Fourier Transform Infrared; D014466:Ultraviolet Rays
D000179:Acrylates; D008567:Membranes, Artificial; D008689:Methacrylates; D011108:Polymers; C031170:2-hydroxy-3-phenoxypropyl methacrylate; C120172:4-hydroxybutyl acrylate; D003000:Clonidine