Case report: Hepatitis A preceding Guillain-Barré syndrome.
A case of acute hepatitis A with Guillain-Barré Syndrome subtype AMAN (acute motor axonal neuropathy) in a 17-year-old male is reported. Serum and cerebrospinal fluid were positive for anti-hepatitis A virus (HAV) IgM, IgG, and IgA. The onset of the syndrome was evident in week 3 of illness. The remarkably high titers of serum anti-HAV IgG appeared unique to a hepatitis A patient with the syndrome. Phylogenetic analysis of the HAV genome detected in the serum and feces revealed genotype IIIA, circulating commonly in Pune, western India.
Chitambar
Shobha D
SD
National Institute of Virology, Pune, Maharashtra, India. chitambars@hotmail.com
Fadnis
Rahul S
RS
Joshi
Madhuri S
MS
Habbu
A
A
Bhatia
S G
SG
D000293:Adolescent; D020275:Guillain-Barre Syndrome / Q000150:complications*; D006506:Hepatitis A / Q000150:complications*; D035922:Hepatitis A Antibodies / Q000097:blood; D030041:Hepatitis A virus / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D012367:RNA, Viral; D013997:Time Factors
D035922:Hepatitis A Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral