Genomic approach for the understanding of dynamic aspect of chromosome behavior.
Various functions are integrated into a single chromosome molecule. The genomic approach (ChIP-chip) we introduce here is a very powerful tool to study dynamic changes of the structure and function of the chromosome at the level of protein-DNA interaction as precisely as possible without prejudice or bias. This technology opens up the way to understand how local protein-protein or protein-DNA interactions lead to the dynamic changes of chromosome structure and how various chromosomal functions are connected to make a network for the faithful maintenance of the genome.
Katou
Yuki
Y
Laboratory of Genome Structure and Function, Division for Gene Research, Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan.
Kaneshiro
Kiyofumi
K
Aburatani
Hiroyuki
H
Shirahige
Katsuhiko
K
D001483:Base Sequence; D002875:Chromosomes; D017931:DNA Primers; D004261:DNA Replication; D023281:Genomics; D020411:Oligonucleotide Array Sequence Analysis
D017931:DNA Primers