[Advances in the pathogenesis of atopic dermatitis].
The incidence of atopic dermatitis (AD) is noticeably increasing in industrialized countries. New insights into the pathogenesis of this disease are mirrored by a changed terminology suggested by the World Allergy Organization: a distinction between a so-called atopic and non-atopic dermatitis. The pathogenesis of the AD, which this article concentrates on, is highly complex. Genetic and environmental factors play a pivotal role in triggering AD. The complex pattern of cytokines and chemokines, reflecting a deviated immune response in AD patients, is a focus of research, as are the involvement of various cells and the epidermal barrier. Research concerning T cells with regulatory features as well as IgE-mediated autoreactivity will soon give insight into the defective tolerance of atopic patients and might possibly lead to new concepts in the management of the disease.
Hinz
T
T
Klinik und Poliklinik für Dermatologie, Universitätsklinikum, Sigmund-Freud-Strasse 25, 53105 Bonn.
Staudacher
A
A
Bieber
T
T
D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D018925:Chemokines / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000523:psychology; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D012106:Research; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D018925:Chemokines; D016207:Cytokines; D007073:Immunoglobulin E