Retinoblastoma tumor suppressor: where cancer meets the cell cycle.
The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.
Knudsen
Erik S
ES
Department of Cell Biology and University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio 45267-0521, USA. erik.knudsen@uc.edu
Knudsen
Karen E
KE
D002453:Cell Cycle / Q000235:genetics*; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D016161:Genes, Retinoblastoma; D006706:Homeostasis; D006801:Humans; D012175:Retinoblastoma / Q000235:genetics* / Q000473:pathology