p16-Positive small cell neuroendocrine carcinoma of the endometrium.
We report herein a small cell neuroendocrine carcinoma of the endometrium that extended to the cervix and showed strong immunohistochemical staining for p16. The p16 staining raised the possibility of a human papillomavirus (HPV)-related tumor, because in the cervix, a positive p16 immunohistochemical stain is presumptive evidence of HPV. However, the current case was HPV negative. We discuss the molecular pathogenesis of non-HPV-related increased p16 expression.
Melgoza
Frank
F
Department of Pathology, University of California Irvine Medical Center, Orange, California 92868, USA. fmelgoza@uci.edu
Brewster
Wendy R
WR
Wilczynski
Sharon
S
Rutgers
Joanne
J
D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry* / Q000209:etiology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000737:chemistry* / Q000209:etiology / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D027383:Papillomaviridae / Q000235:genetics; D025803:Tumor Suppressor Protein p14ARF / Q000032:analysis*
D004279:DNA, Viral; D025803:Tumor Suppressor Protein p14ARF