[Abnormal expression of cCD79a/cCD22 in acute myeloid leukemia with t (8;21)].
OBJECTIVE
To report abnormal expression of cCD79a/cCD22 in four cases of acute myeloid leukemia (AML) with t (8;21).


METHODS
The characteristics of morphology, immunophenotype, chromosome karyotype (MIC) and clinical manifestations of 4 AML patients with t (8;21) expressing cCD79a/cCD22 were analyzed.


RESULTS
The features of the 4 patients were: (1) no difference in gender; (2) young age; (3) exmedullary infiltration may be present; (4) normal number of white blood cells in peripheral blood; (5) morphology showed acute myeloid leukemia with high percentage of blast cells; (6) B-lymphoid and myeloid immunophenotype, and high expression of CD34; (7) frequent depletion of Y chromosome and complex changes of chromosomes; (8) positive for AML1/ETO fusion gene; (9) response well to chemotherapy regimen which simultaneously treated myeloid and lymphocytic leukemia.


CONCLUSIONS
Abnormal expression of cCD79a/cCD22 in AML with t (8;21) (q22;q22) suggested that this kind of leukemia might be related with abnormal expression gene of B cell.
He
Guang-sheng
GS
First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.
Zhou
Ling
L
Wu
De-pei
DP
Xue
Yong-quan
YQ
Zhu
Ming-qing
MQ
Liu
Dan-dan
DD
Sun
Ai-ning
AN
Jin
Zheng-ming
ZM
Qiu
Hui-ying
HY
Miao
Miao
M
Tang
Xiao-wen
XW
Fu
Zheng-zheng
ZZ
Ma
Xiao
X
Wang
Xiu-li
XL
D000293:Adolescent; D000328:Adult; D051925:CD79 Antigens / Q000378:metabolism*; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000378:metabolism*; D014178:Translocation, Genetic; D055815:Young Adult
D051925:CD79 Antigens; D051918:Sialic Acid Binding Ig-like Lectin 2