Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
This study was intended to evaluate the anti-inflammatory, antipyretic and analgesic activities of aqueous and ethanol extracts of Phrygilanthus acutifolius flowers in several experimental standard models in rats, following oral administration. The results showed that the aqueous extract significantly reduced the oedema induced by carrageenan within 1-5 h post-dosing at all dose levels used. On the analgesia property, acetic acid-induced writhing was significantly reduced. In the formalin test, the extract also significantly decreased the painful stimulus in both phases of the test. The tail immersion confirms central acting analgesic property of the extracts. Overall, the analgesic tests conducted revealed that the extract had central and peripheral properties. Its effects on pyresis were also appreciable. It significantly reduced fever at doses greater than 200 mg/kg within 2 h on yeast-induced hyperthermia in rats.
Daud
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A
Departamento de Biología del Desarrollo, Instituto Superior de Investigaciones Biológicas y Universidad Nacional de Tucumán, Chacabuco 461, 4000-San Miguel de Tucumán, Tucumán, Argentina.
Habib
N
N
Riera
A Sánchez
AS
D019342:Acetic Acid; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001118:Argentina; D002351:Carrageenan; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005334:Fever / Q000517:prevention & control; D035264:Flowers / Q000737:chemistry*; D005557:Formaldehyde; D007213:Indomethacin / Q000494:pharmacology; D028183:Loranthaceae / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional; D009437:Neuralgia / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000379:methods; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014867:Water
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014867:Water; D004008:Diclofenac; D005557:Formaldehyde; D002351:Carrageenan; D019342:Acetic Acid; D007213:Indomethacin