title: NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis.
abstract: BACKGROUND
  Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases.
  
  
  OBJECTIVE
  To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-control study.
  
  
  METHODS
  Seventy-five patients with symptomatic collagenous colitis and 534 healthy blood donors were genotyped for SNP 8, 12, and 13 of the NOD2/CARD15 gene using TaqMan technology. Susceptibility to collagenous colitis was tested using Chi(2)-test comparing the carrier status of the rare allele.
  
  
  RESULTS
  The carrier frequency of the rare allele in SNP 8, 12, and 13 was 9.5, 1.3, and 8.1% in patients with collagenous colitis and 8.9, 1.1, and 8.4% in healthy blood donors, respectively. There were no significant differences in allele-, genotype, and carrier frequency (p>0.05).
  
  
  CONCLUSIONS
  Our data suggest that functional polymorphisms in the NOD2/CARD15 gene might not be involved in the susceptibility to collagenous colitis.
authors.affiliation: Medical Department I, Technical University Hospital, Fetscherstr. 74, D-01307 Dresden, Germany. ahmed.madisch@uniklinikum-dresden.de
authors.forename: Ahmed
authors.initials: A
authors.lastname: Madisch
authors.forename: Stephan
authors.initials: S
authors.lastname: Hellmig
authors.forename: Stephan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Birgit
authors.initials: B
authors.lastname: Bethke
authors.forename: Manfred
authors.initials: M
authors.lastname: Stolte
authors.forename: Stephan
authors.initials: S
authors.lastname: Miehlke
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D046729:Colitis, Collagenous / Q000209:etiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein