title: A [3 + 3] annelation approach to tetrahydropyridines.
abstract: [reaction: see text] A stepwise [3+3] annelation sequence to tetrahydropyridines via addition of the Büchi Grignard to aziridines has been developed. These intermediates can be further functionalized with good regio- and stereocontrol and this methodology has been employed in the stereoselective formal synthesis of (-)-dihydropinidine.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, UK.
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Pattenden
authors.forename: Robert A J
authors.initials: RA
authors.lastname: Wybrow
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Smith
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D010880:Piperidines; D011725:Pyridines; C409726:dihydropinidine