An unusual case with membranous lipodystrophy in a hypertensive patient with transepidermal elimination.
Membranous lipodystrophy represents a peculiar type of fat necrosis that is present in patients with various types of skin disease. It is characterized by the presence of microcysts and macrocysts and is lined by amorphous eosinophilic material with a crenelated arabesque appearance. These findings have been associated with lupus erythematosus, diabetes mellitus, erythema nodosum, trauma, etc. We report a case of a 43-year-old woman who had a red to purple asymptomatic indurated plaque, approximately seven cm in diameter and on the left arm. She was a chronic hepatitis B antigen carrier and had hypertension for four years. Histopathology of the biopsied lesion showed transepidermal elimination of altered collagen and elastic fibers, as well as membranous lipodystrophy changes. There were hypertensive vascular changes including lymphohistiocytic infiltration around the vascular wall, swelling of endothelial cells, increased thickness of the vascular walls, and narrowing of the lumen. We report a case showing transepidermal elimination with membranous lipodystrophy. We carefully suggest that the secondary phenomenon of transepidermal elimination was associated with membranous lipodystrophy and degenerate connective tissues.
Bak
Hana
H
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Kangwon-do 220-701, Korea.
Lee
Jin Wook
JW
Ahn
Hyung Jin
HJ
Hwang
Sang Min
SM
Choi
Eung Ho
EH
Lee
Seung Hun
SH
Ahn
Sung Ku
SK
D000328:Adult; D004817:Epidermis / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008060:Lipodystrophy / Q000150:complications* / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*