Protein-peptide interaction studies demonstrate the versatility of calmodulin target protein binding.
Calmodulin (CaM) is a prototypical Ca2+-sensor protein that can control many important biological functions by binding to hundreds of target proteins. To gain insight into the versatility of CaM-target recognition, we have analyzed the complex structures for many types of CaM-binding peptides and some target proteins. In particular, some recently reported novel complex structures reveal that the versatile target binding of CaM is accommodated by its flexible domain arrangement and the malleability of its interfaces.
Ishida
Hiroaki
H
Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, T2N 1N4, Canada.
Vogel
Hans J
HJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002147:Calmodulin / Q000737:chemistry / Q000378:metabolism; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008958:Models, Molecular; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D009419:Nerve Tissue Proteins / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020539:Sequence Analysis, Protein; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000378:metabolism; D014757:Viper Venoms / Q000378:metabolism
C489363:Basp1 protein, mouse; D002147:Calmodulin; D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010455:Peptides; D010940:Plant Proteins; D051640:Small-Conductance Calcium-Activated Potassium Channels; D014757:Viper Venoms; C416405:edema factor; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D052250:Nitric Oxide Synthase Type III; D017346:Protein Serine-Threonine Kinases; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase; D005968:Glutamate Decarboxylase; D000252:Calcium-Transporting ATPases; D002118:Calcium