Carney complex.
We report an illustrated case of a 61-year-old woman with multiple atrial myxomas and cutaneous hyperpigmentation as part of the Carney complex. The case is notable for an unusually late presentation in life and a strong family history of atrial myxomas and sudden death. The importance of regular life-long echocardiographic screening and surveillance in all family members of affected cases is emphasized.
Zahedi
Rayhaneh G
RG
Southampton University Hospital, Southampton, Hampshire, United Kingdom.
Wald
David S
DS
Ohri
Sunil
S
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000235:genetics / Q000601:surgery; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics*; D004252:DNA Mutational Analysis; D016757:Death, Sudden, Cardiac; D005260:Female; D018226:Fibroadenoma / Q000235:genetics / Q000601:surgery; D005799:Genes, Dominant; D005820:Genetic Testing; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000601:surgery; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D006801:Humans; D017495:Hyperpigmentation / Q000453:epidemiology / Q000235:genetics*; D007911:Lentigo / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D009508:Nevus, Pigmented / Q000235:genetics; D010375:Pedigree; D014463:Ultrasonography
D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; C517834:PRKAR1A protein, human; D017868:Cyclic AMP-Dependent Protein Kinases