Phosphatidylinositol 4-kinases: old enzymes with emerging functions.
Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.
Balla
Andras
A
Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
Balla
Tamas
T
D019870:1-Phosphatidylinositol 4-Kinase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D007527:Isoenzymes; D050356:Lipid Metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D015398:Signal Transduction; D022161:Transport Vesicles / Q000378:metabolism
D007527:Isoenzymes; D018129:Phosphatidylinositol Phosphates; C037178:phosphatidylinositol 4-phosphate; D019870:1-Phosphatidylinositol 4-Kinase