title: Identification of cis-acting regions that contribute to neuron-specific expression of the GAP-43 gene.
abstract: There are two transcription start sites in the growth-associated protein 43 (GAP-43) promoter, and several repressive elements have been reported in the control region. But the repressive effects have been analyzed only for the distal transcription start site. Among the repressive elements reported, we found that modulator I repressed GAP-43 gene expression from the proximal promoter in non-neuronal cells. We also found a novel stimulative element immediately downstream of modulator I.
authors.affiliation: Department of Biotechnology, Graduate School of Engieering, Nagoya University.
authors.forename: Mikio
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakagami
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Miyake
authors.forename: Shinji
authors.initials: S
authors.lastname: Iijima
mesh_terms: D000818:Animals; D002460:Cell Line; D019922:GAP-43 Protein / Q000235:genetics*; D017353:Gene Deletion; D005786:Gene Expression Regulation / Q000235:genetics*; D051379:Mice; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D019922:GAP-43 Protein