title: The need for future surgical low rectal cancer studies.
abstract: Optimal surgery remains the mainstay of best outcome for rectal cancer. The demonstration, during the 3rd Annual Pelican Surgical Workshop Symposium, of an abdomino-perineal excision (APE) performed in the 'Berlin position', further added to the debate on optimal surgical technique. Much interest was created at the 1st Pelican symposium with the demonstration, by the Swedish surgeon Dr Torbjorn Holm, of a prone APE and the delivery of a 'cylindrical' specimen and the potential to reduce local recurrence using this approach. The high rates of local recurrence following APE and the discussions as to optimal technique have led to the development of a proposed MERCURY Study Group study to assess the benefit of a radical APE, with careful assessment of the impact that this operation may have on morbidity. A German study has also been proposed adopting the UK's multidisciplinary team approach. It aims at targeting preoperative chemoradiotherapy at those patients in whom a radical APE or total mesorectal excision is likely to result in an involved surgical resection margin. In this article we review the evidence for improving the surgical technique for low rectal cancer. We believe improvements may be best achieved through continued European prospective, multi-centre, multidisciplinary studies.
authors.affiliation: Royal Devon and Exeter Hospital, Exeter, Devon, UK. i.daniels@pelicancancer.org
authors.forename: I R
authors.initials: IR
authors.lastname: Daniels
authors.forename: J
authors.initials: J
authors.lastname: Strassburg
authors.forename: B J
authors.initials: BJ
authors.lastname: Moran
mesh_terms: D002986:Clinical Trials as Topic; D013505:Digestive System Surgical Procedures / Q000379:methods*; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010502:Perineum / Q000601:surgery*; D011187:Posture; D012004:Rectal Neoplasms / Q000601:surgery*; D012007:Rectum / Q000601:surgery*