[Inhibition of peridural fibrosis after laminectomy using biological sheet in rat model].
The prevention of fibrosis after lumbar and thoracic laminectomies by avoiding herniation of muscular tissue was studied using Wistar-EPM rats with a biological membrane made of decorticated bone of bovine material. The rats were sacrificed after eight, sixteen and twenty four weeks and the material was sent to anatomopathological study. This membrane proved to be biocompatible and its efficacy was seen by allowing formation of bone and preventing muscular tissue invasion of the epidural space and avoiding adherences.
Herculano
Marco Antonio
MA
Disciplina de Neurocirurgia e Departamento de Patologia da Escola Paulista de Medicina da Universidade Federal de São Paulo, Brazil. herculano.ncir@proxy.com.br
de Tella
Oswaldo Ignácio
OI
Prandini
Mirto Nelso
MN
de Seixas Alves
Maria Teresa
MT
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002417:Cattle; D004824:Epidural Space / Q000473:pathology*; D005355:Fibrosis / Q000473:pathology / Q000517:prevention & control; D007796:Laminectomy / Q000379:methods*; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D008297:Male; D008567:Membranes, Artificial; D051381:Rats; D017208:Rats, Wistar; D013904:Thoracic Vertebrae / Q000473:pathology / Q000601:surgery*
D001672:Biocompatible Materials; D008567:Membranes, Artificial