title: Skeletal myogenesis by human embryonic stem cells.
abstract: We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.
authors.affiliation: Center for Developmental Biology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jun Ke
authors.initials: JK
authors.lastname: Zheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Aditi
authors.initials: A
authors.lastname: Karandikar
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Gai
authors.forename: Ai Lian
authors.initials: AL
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Peng
authors.forename: Hui Zhen
authors.initials: HZ
authors.lastname: Sheng
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D054715:Cardiotoxins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology*; D019172:Transplantation Conditioning; D014183:Transplantation, Heterologous
chemical_list: D015415:Biomarkers; D054715:Cardiotoxins