title: In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa.
abstract: Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 microg of oleanolic acid per gram of body weight.
authors.affiliation: Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia, Apartado 4314, Lima 100, Perú.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Moura-Letts
authors.forename: León F
authors.initials: LF
authors.lastname: Villegas
authors.forename: Ana
authors.initials: A
authors.lastname: Marçalo
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D029748:Caryophyllaceae / Q000737:chemistry*; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009828:Oleanolic Acid