Cross-species oncogenomics in cancer gene identification.
The complexity of genomic aberrations in most human tumors hampers delineation of the genes that drive the tumorigenic process. In this issue of Cell, and demonstrate that cognate mouse tumor models recapitulate these genetic alterations with unexpected fidelity. These results indicate that cross-species genomic analysis is a powerful strategy to identify the responsible genes and assess their oncogenic capacity in the appropriate genetic context.
Peeper
Daniel
D
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. d.peeper@nki.nl
Berns
Anton
A
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D018797:Cell Cycle Proteins; D023281:Genomics; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics; D008545:Melanoma / Q000235:genetics; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics; D009857:Oncogenes; D010750:Phosphoproteins / Q000235:genetics; D013045:Species Specificity; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D051034:Inhibitor of Apoptosis Proteins; C099942:NEDD9 protein, human; D009687:Nuclear Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D014157:Transcription Factors; C456659:YY1AP1 protein, human