Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?
Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.
Méhats
Céline
C
Institut National de la Santé et de la Recherche Médicale, INSERM U427 Paris, Faculté de Pharmacie, France. mehats@cochin.inserm.fr
Schmitz
Thomas
T
Breuiller-Fouché
Michelle
M
Leroy
Marie-Josèphe
MJ
Cabrol
Dominique
D
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011247:Pregnancy; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014590:Uterine Contraction / Q000187:drug effects*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases