title: Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals.
abstract: The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003. For reasons unknown, the SARS virus is less severe and the clinical progression a great deal milder in children younger than 12 years of age. In contrast, the mortality rate can exceed 50% for persons at or above the age of 60. As part of the Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA), an immune phage-display library is being created from convalescent patients in a phagemid system for the selection of single-chain fragment variables (scFv) antibodies recognizing the SARS-CoV.
authors.affiliation: Department of Molecular Biology, University of Aarhus, Denmark.
authors.forename: Morten Draeby
authors.initials: MD
authors.lastname: Sørensen
authors.forename: Brian
authors.initials: B
authors.lastname: Sørensen
authors.forename: Regina
authors.initials: R
authors.lastname: Gonzalez-Dosal
authors.forename: Connie Jenning
authors.initials: CJ
authors.lastname: Melchjorsen
authors.forename: Jens
authors.initials: J
authors.lastname: Weibel
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Chen Wie
authors.initials: CW
authors.lastname: Jun
authors.forename: Yang
authors.initials: Y
authors.lastname: Huanming
authors.forename: Peter
authors.initials: P
authors.lastname: Kristensen
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D000998:Antiviral Agents / Q000276:immunology / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007128:Immunoglobulin Fragments / Q000276:immunology; D019151:Peptide Library; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012699:Serology; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007128:Immunoglobulin Fragments; D019151:Peptide Library