title: "Juvenile" oncology--a missing subspecialty. The experience of a reference cancer centre.
abstract: BACKGROUND
  Despite unique tumor epidemiology and a higher cancer incidence compared to pediatric patients, adolescents and young adults have not been receiving specialized, multidisciplinary, centralized care. In an effort to emphasize this need, we present outcome and toxicity data from a reference centre.
  
  
  METHODS
  Cohort of 150 patients aged 15-30 treated for malignant tumors of lymphoid and solid organs from 1986 to 2002.
  
  
  RESULTS
  Patients aged 15-19 commonly had lymphomas, germ cell tumors and pediatric sarcomas, whereas those aged 20-30 experienced germ cell tumors, lymphomas, melanomas and epithelial tumors more often. Overall 5- and 10-year survival was 80%, whereas 5-year and 10-year time to treatment failure was 68% and 43.5% respectively. 24% of patients experienced persistent, late treatment-related toxicities that interfered with their normal lifestyle.
  
  
  CONCLUSIONS
  Despite the need for specialized care, psychosocial support and enrollment in clinical trials, youngsters have not been recognized as a patient group with distinct needs. Development of "Juvenile" oncology is required.
authors.affiliation: Department of Medical Oncology, Ioannina University Hospital, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Pentheroudakis
authors.forename: Davide
authors.initials: D
authors.lastname: Mauri
authors.forename: Lida
authors.initials: L
authors.lastname: Kostadima
authors.forename: Vassilis
authors.initials: V
authors.lastname: Golfinopoulos
authors.forename: George
authors.initials: G
authors.lastname: Alexiou
authors.forename: Anestis
authors.initials: A
authors.lastname: Karakatsanis
authors.forename: Nicholas
authors.initials: N
authors.lastname: Pavlidis
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data; D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D002173:Cancer Care Facilities / Q000706:statistics & numerical data*; D003953:Diagnosis-Related Groups; D005260:Female; D006115:Greece / Q000453:epidemiology; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D033183:Interdisciplinary Communication; D008297:Male; D008495:Medical Oncology; D009369:Neoplasms / Q000453:epidemiology* / Q000523:psychology / Q000628:therapy; D010348:Patient Care Team; D010372:Pediatrics; D011183:Postoperative Complications / Q000453:epidemiology; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects; D012017:Referral and Consultation; D012189:Retrospective Studies; D012944:Social Support; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents