Coagulation and sepsis.
Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.
Machado
F R
FR
Napoleão de Barros 715 4a andar São Paulo, SP 04024-002, Brazil. genauhaus@uol.com.br
Silva
E
E
D000991:Antithrombins / Q000276:immunology / Q000378:metabolism; D001777:Blood Coagulation / Q000276:immunology* / Q000502:physiology; D001779:Blood Coagulation Factors / Q000276:immunology / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000097:blood / Q000276:immunology / Q000378:metabolism; D018805:Sepsis / Q000097:blood* / Q000276:immunology / Q000378:metabolism
D000991:Antithrombins; D001779:Blood Coagulation Factors; D008074:Lipoproteins; D011956:Receptors, Cell Surface; C091963:activated protein C receptor; C051928:lipoprotein-associated coagulation inhibitor