Effect of topical mitomycin C for antrostomy in rabbit with sinusitis.
The aim of this study is to evaluate if mitomycin C (MMC), applied topically at the site of maxillary antrostomy in experimentally inflamed maxillary sinuses, may reduce postoperative ostial stenosis without any harmful effect. Twenty-four rabbits with experimentally induced maxillary sinusitis underwent maxillary antrostomy bilaterally. MMC at a concentration of 0.4 or 1 mg/ml was applied at the site of antrostomy on the right whilst the antrostomy site on the left served as the control. Half of each MMC concentration group of animals were killed after 3 weeks, and the remaining half after 6 weeks. For every rabbit, the areas of antrostomies were measured and mucosal specimens around the ostia were obtained for microscopic evaluation at the time of antrostomy and killing. Within each MMC concentration group, MMC-treated antrostomies were significantly wider than those of the controls (P < 0.05), even after 6 weeks. However, comparison of the areas of MMC-treated antrostomies between the two MMC concentration groups did not show any significant difference (P > 0.05). No systemic side effect or permanent mucosal damage was detected. These results suggest that postoperative topical MMC at a concentration of 0.4 mg/ml can be used to prolong the patency of maxillary antrostomy in an inflammed sinus.
Park
Seok-Won
SW
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Dongguk University, Goyang, South Korea.
Koo
Bon Seok
BS
Park
Yong Ho
YH
Jin
Yong De
YD
Rha
Ki Sang
KS
D000287:Administration, Topical; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D002921:Cicatrix / Q000517:prevention & control; D004195:Disease Models, Animal; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D012852:Sinusitis / Q000188:drug therapy* / Q000601:surgery; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin