Synthesis and anti-inflammatory activity of some selected aminothiophene analogs.
Some 2-aminothiophene analogs 1-6 were synthesized and characterized. Among the tested compounds, compound 1 (IC50 121.47 microM) exhibited highest while the compound 5 showed least anti-inflammatory potential (IC50 422 microM).
Khan
Khalid Mohammed
KM
International Centerfor Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. hassaan2@super.net.pk
Ullah
Zia
Z
Nullah
Zia
Z
Lodhi
Muhammad Arif
MA
Jalil
Saima
S
Choudhary
Muhammad Iqbal
MI
Atta-Ur-Rahman
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013876:Thiophenes