title: Safety of argon plasma coagulation for hemostasis during endoscopic mucosal resection.
abstract: Showing the safety of argon plasma coagulation (APC) over mucosal defects during/after endoscopic mucosal resection (EMR), 2 studies using resected pig (ex vivo) and living minipig (in vivo) stomachs were performed. As an ex vivo study, APC was applied over mucosal defects in 2 groups; with prior submucosal saline injection and without injection. Only subtle tissue damage was observed in the injection group, whereas apparent damage was observed in the noninjection group. The damaged distances in depth significantly increased as the pulse duration increased and those at the pulse duration of 4 seconds, which might be maximal in clinical practice, were approximately 1 mm. As an in vivo study, APC was applied over mucosal defects immediately after EMR. Only subtle tissue damage was observed even at the pulse duration of 20 seconds as shown in the ex vivo study. APC can be performed safely over the mucosal defects during/after EMR.
authors.affiliation: Department of Gastroenterology, Graduate school of Medicine, University of Tokyo, Tokyo, Japan. mtfujish-kkr@umin.ac.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Fujishiro
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yahagi
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakamura
authors.forename: Naomi
authors.initials: N
authors.lastname: Kakushima
authors.forename: Shinya
authors.initials: S
authors.lastname: Kodashima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ono
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Takuhei
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Nobutake
authors.initials: N
authors.lastname: Yamamichi
authors.forename: Ayako
authors.initials: A
authors.lastname: Tateishi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masashi
authors.initials: M
authors.lastname: Oka
authors.forename: Masao
authors.initials: M
authors.lastname: Ichinose
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000818:Animals; D001128:Argon; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004564:Electrocoagulation / Q000295:instrumentation*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000473:pathology*; D016558:Hemostasis, Endoscopic / Q000295:instrumentation*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001128:Argon