title: Gliomas and farm pesticide exposure in men: the upper midwest health study.
abstract: The National Institute for Occupational Safety and Health evaluated farm pesticide exposure and glioma risk in a study that included 457 glioma cases and 648 population-based controls, all adult men (18-80 yr old) and nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. Multiple logistic regressions were used to control for farm residence, age, age group, education, and exposure to other pesticides. No associations were found between glioma and 12 specific pesticides. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and found reduced glioma risk for insecticides (OR = 0.53, CI = 0.37-0.77), fumigants (OR = 0.57, CI = 0.34-0.95), and organochlorines (OR = 0.66, CI = 0.47-0.94). In analyses excluding proxy respondents (47% of cases) most CIs included 1.0. No positive association of farm pesticide exposure and glioma was found. Other farm exposures may explain the excess brain cancer risk seen in previous studies.
authors.affiliation: Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. amr2@cdc.gov
authors.forename: Avima M
authors.initials: AM
authors.lastname: Ruder
authors.forename: Martha A
authors.initials: MA
authors.lastname: Waters
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Butler
authors.forename: Tania
authors.initials: T
authors.lastname: Carreón
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Calvert
authors.forename: Karen E
authors.initials: KE
authors.lastname: Davis-King
authors.forename: Paul A
authors.initials: PA
authors.lastname: Schulte
authors.forename: Wayne T
authors.initials: WT
authors.lastname: Sanderson
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Ward
authors.forename: L Barbara
authors.initials: LB
authors.lastname: Connally
authors.forename: Ellen F
authors.initials: EF
authors.lastname: Heineman
authors.forename: Jack S
authors.initials: JS
authors.lastname: Mandel
authors.forename: Roscoe F
authors.initials: RF
authors.lastname: Morton
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Reding
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Rosenman
authors.forename: Glenn
authors.initials: G
authors.lastname: Talaska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000453:epidemiology*; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005910:Glioma / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*; D018570:Risk Assessment; D012307:Risk Factors; D014922:Wisconsin / Q000453:epidemiology
chemical_list: D010575:Pesticides