Emulsification preparation of chitosan-urethane microbeads in the presence of a water-soluble blocked diisocyanate, containing furanone homosyrine lactone bacterial inhibitors.
Chitosan is an abundant naturally occurring biopolymer that is biocompatible, of low toxicity and is well suited as a carrier for a range of active agents. Restrictions imposed by this biopolymers unique solubility requirements make if difficult to process. One approach to an internal setting system is to employ the water-soluble blocked isocyanate hexamethylene-1,6-di(aminocarboxysulphonate) (HDACS) in order to cross-link the chitosan and form microspheres in situ utilizing simple emulsion systems. Chitothane microspheres are capable of delivering active agents at controlled release rates and offers a viable alternative to external set methodologies utilizing aldehydes or similar cross-linking agents.
Price
R R
RR
Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA. rprice@cbmse.NRL.NAVY.MIL
Passaro
L C
LC
Welsh
E R
ER
D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000378:metabolism; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D017953:Isocyanates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D015394:Molecular Structure; D012995:Solubility; D014520:Urethane / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D017953:Isocyanates; D014867:Water; D014520:Urethane; D048271:Chitosan