title: Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis.
abstract: Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with nondetectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.
authors.affiliation: Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599-7435, USA. gammon@unc.edu
authors.forename: Marilie D
authors.initials: MD
authors.lastname: Gammon
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Sagiv
authors.forename: Sybil M
authors.initials: SM
authors.lastname: Eng
authors.forename: Sumitra
authors.initials: S
authors.lastname: Shantakumar
authors.forename: Mia M
authors.initials: MM
authors.lastname: Gaudet
authors.forename: Susan L
authors.initials: SL
authors.lastname: Teitelbaum
authors.forename: Julie A
authors.initials: JA
authors.lastname: Britton
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Terry
authors.forename: Lian Wen
authors.initials: LW
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.forename: Steve D
authors.initials: SD
authors.lastname: Stellman
authors.forename: Jan
authors.initials: J
authors.lastname: Beyea
authors.forename: Maureen
authors.initials: M
authors.lastname: Hatch
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Kabat
authors.forename: Mary S
authors.initials: MS
authors.lastname: Wolff
authors.forename: Bruce
authors.initials: B
authors.lastname: Levin
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.forename: Regina M
authors.initials: RM
authors.lastname: Santella
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D018736:DNA Adducts; D004198:Disease Susceptibility; D004781:Environmental Exposure / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011159:Population Surveillance; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons