Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology.
Asymmetric cell division is an evolutionarily conserved mechanism widely used to generate cellular diversity during development. Drosophila neuroblasts have been a useful model system for studying the molecular mechanisms of asymmetric cell division. In this minireview, we focus on recent progress in understanding the role of heterotrimeric G proteins and their regulators in asymmetric spindle geometry, as well as the role of an Inscuteable-independent microtubule pathway in asymmetric localization of proteins in neuroblasts. We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology.
Yu
Fengwei
F
Howard Hughes Medical Institute and Departments of Physiology, Biochemistry, and Biophysics, University of California, Rock Hall, 1550 Fourth Street, San Francisco, California 94143, USA.
Kuo
Chay T
CT
Jan
Yuh Nung
YN
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D008941:Spindle Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D029721:Drosophila Proteins; D019204:GTP-Binding Proteins