Estrus variation in anticonflict-like effects of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of female Wistar rats.
Anticonflict-like effects of the mGlu5 receptor antagonist MTEP (systemic administrations: 1.50, 3.0 or 6.0 mg/kg; i.p.; intra-lateral septal nuclei or intra-medial septal region infusions: 2.5 microg/microl, 5.0 microg/microl or 10.0 microg/microl) were assessed in Wistar rats during late proestrus or metestrus-diestrus. Results showed that control rats displayed an increased number of immediately punished reinforcers during late proestrus (P < 0.05), when compared to metestrus-diestrus. During late proestrus, systemic administrations (3.0 mg/kg, P < 0.05; 6.0 mg/kg P < 0.05) or intra-lateral septal nuclei infusions (5.0 microg/microl, P < 0.05; 10.0 microg/microl, P < 0.05) of MTEP increased the number of immediately punished reinforcers received. During metestrus-diestrus only the highest doses of MTEP (systemic administration: 6.0 mg/kg P < 0.05; intra-lateral septal nuclei infusions: 10.0 microg/microl, P < 0.05) increased the number of immediately punished reinforcers obtained. MTEP infusions into the medial septum produced neither of these anticonflict effects. In conclusion, data showed an estrus variation in those anticonflict-like effects of the mGlu5 receptor antagonist MTEP, systemically administered or microinjected into lateral septal nuclei of female Wistar rats.
Molina-Hernández
M
M
Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México. mimoli@todito.com
Tellez-Alcántara
N P
NP
Pérez-García
J
J
Olivera-Lopez
J I
JI
Jaramillo
M Teresa
MT
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D003216:Conditioning, Operant; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D005260:Female; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D012686:Septal Nuclei / Q000473:pathology; D013844:Thiazoles / Q000494:pharmacology*
C472365:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D013844:Thiazoles