Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes.
OBJECTIVE
The purpose of this study was to evaluate the efficacy of intratympanic administration of dexamethasone (IT-DEX) treatment on sudden sensorineural hearing loss (SSNHL) patients with diabetes by comparing the results with intravenous administration of dexamethasone (IV-DEX) treatment.


METHODS
Comparative study.


METHODS
University hospital and affiliated hospital.


METHODS
Ten sequential SSNHL patients with diabetes receiving IT-DEX and 21 sequential SSNHL patients with diabetes receiving IV-DEX. Patients with low tone hearing loss were excluded.


METHODS
In the IT-DEX group, two methods were applied to deliver DEX (4 mg/ml): injection through a perforation made by laser-assisted myringotomy or through a tympanostomy tube. IT-DEX administration was performed on 8 sequential days. In the IV-DEX group, DEX was administrated intravenously starting from an amount of 8 mg/d followed by taped doses for 10 days.


METHODS
Preprocedure and postprocedure hearing levels and complications.


RESULTS
In the IT-DEX group, the average hearing level before the treatment was 79 dB. Overall, all 10 patients showed improvement of more than 10 dB in the pure-tone audiogram, with a mean improvement of 41 dB. Seven patients (70%) demonstrated successful results, and four recovered completely. In the IV-DEX group, 14 (67%) of the 21 patients showed improvement of more than 10 dB with a mean improvement of 25 dB. Thirteen patients (62%) demonstrated successful results. Free blood sugar during and after the IT-DEX treatment remained below the pretreatment levels, whereas four patients in the IV-DEX group demonstrated worsening of the hyperglycemia.


CONCLUSIONS
IT-DEX treatment is at least as effective as IV-DEX treatment for SSNHL patients with diabetes.
Kakehata
Seiji
S
Department of Otorhinolaryngology, Hirosaki University School of Medicine, Hirosaki, Japan. seijik@cc.hirosaki-u.ac.jp
Sasaki
Akira
A
Oji
Kasumi
K
Futai
Kazunori
K
Ota
Shuji
S
Makinae
Kimitoshi
K
Shinkawa
Hideichi
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D048909:Diabetes Complications / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D008876:Middle Ear Ventilation; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000601:surgery*
D005938:Glucocorticoids; D003907:Dexamethasone