title: [Renal transplantation with positive crossmatch].
abstract: BACKGROUND
  Lymphocytotoxic antibodies reduce the expectancy of renal transplantation due to the increased risk of a positive crossmatch.
  
  
  METHODS
  We analyzed the evolution of eight kidney transplants performed in our unit in presence of a positive crossmatch with historical T and/or B lymphocyte positive crossmatches.
  
  
  RESULTS
  Mean panel reactivity was 76,6 +/- 25,7% (r: 22-100%), been higher than 75% in six patients. Six patients were recipients of a second or third transplant. Immunosuppression consisted of quadruple therapy including induction with thymoglobuline. Five patients had delayed graft function, and one had primary non-function of the graft. One patient lost her graft due to chronic allograft nephropathy in the second year postransplantation. Six patients maintained a good renal function (serum creatinine 1,2 +/- 0,5 mg/dl, proteinuria 0,20 +/- 0,34 g/day).
  
  
  CONCLUSIONS
  Renal transplantation in presence of a positive cross-match with historical serum and T lymphocytes and/or B lymphocytes, was followed by a satisfactory graft survival.
authors.affiliation: Servicio de Nefrología, Hospital Universitari Dr Peset, Valencia. asanchoc@senefro.org
authors.forename: A
authors.initials: A
authors.lastname: Sancho
authors.forename: E
authors.initials: E
authors.lastname: Gavela
authors.forename: J F
authors.initials: JF
authors.lastname: Crespo
authors.forename: J L
authors.initials: JL
authors.lastname: Górriz
authors.forename: A
authors.initials: A
authors.lastname: Avila
authors.forename: A
authors.initials: A
authors.lastname: Nuñez
authors.forename: P
authors.initials: P
authors.lastname: Molina
authors.forename: J L
authors.initials: JL
authors.lastname: García-Ramos
authors.forename: J
authors.initials: J
authors.lastname: Montoro
authors.forename: L M
authors.initials: LM
authors.lastname: Pallardó
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies