title: Extrahepatic metabolism and renal effects of sevoflurane in a case of liver transplantation.
abstract: In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and beta2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days. The NAG levels were greater than normal despite the peak serum inorganic fluoride concentration of 18.94 micromol/L. No impairment was observed in serum BUN or creatinine levels in these periods.
authors.affiliation: Department of Anesthesiology and Reanimation, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Erdem
authors.forename: M
authors.initials: M
authors.lastname: Kanbak
authors.forename: F
authors.initials: F
authors.lastname: Saricaoglu
authors.forename: T
authors.initials: T
authors.lastname: Ocal
authors.forename: C
authors.initials: C
authors.lastname: Tanyel
authors.forename: N
authors.initials: N
authors.lastname: Ertaş
authors.forename: A
authors.initials: A
authors.lastname: Berkkan
authors.forename: U
authors.initials: U
authors.lastname: Aypar
mesh_terms: D000117:Acetylglucosamine / Q000652:urine; D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007677:Kidney Function Tests; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology*; D008738:Methyl Ethers / Q000627:therapeutic use*; D011184:Postoperative Period; D000077149:Sevoflurane; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D001613:beta 2-Microglobulin; D000077149:Sevoflurane; D000117:Acetylglucosamine