Association between exposure to cadmium and blood pressure in Japanese peoples.
The authors studied the effects of environmental cadmium exposure on blood pressure (BP). Subjects 1140 men and 1713 women, aged > or =50 yr lived in three areas of Japan considered "unpolluted" by cadmium. Multiple logistic regression analysis was used to evaluate relationships between hypertension/nonhypertension and cadmium concentrations in blood (B-Cd) or urine (U-Cd). Age, body mass index, drinking and smoking habits, and blood and urine chemistry data were incorporated into the model. Odds ratios for hypertension were significantly less than 1 in either gender when U-Cd was the indicator of cadmium exposure and hypertension was defined as systolic BP > or =140 mmHg and/or diastolic BP > or =90 mmHg. The results suggest a significant negative association between cadmium exposure and BP in inhabitants in Japan.
Kurihara
Isao
I
Chiba University Graduate School of Medicine, Department of Occupational and Environmental Medicine, Chiba, Japan.
Kobayashi
Etsuko
E
Suwazono
Yasushi
Y
Uetani
Mirei
M
Inaba
Takeya
T
Oishiz
Mitsuhiro
M
Kido
Teruhiko
T
Nakagawa
Hideaki
H
Nogawa
Koji
K
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D016021:Epidemiologic Studies; D005260:Female; D005843:Geography; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
D002104:Cadmium