title: Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses.
abstract: We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.
authors.affiliation: Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Chapman
authors.forename: N
authors.initials: N
authors.lastname: Tubridy
authors.forename: M J
authors.initials: MJ
authors.lastname: Cook
authors.forename: P J
authors.initials: PJ
authors.lastname: Mitchell
authors.forename: L R
authors.initials: LR
authors.lastname: MacGregor
authors.forename: C
authors.initials: C
authors.lastname: Lovelock
authors.forename: L
authors.initials: L
authors.lastname: Litewka
authors.forename: L
authors.initials: L
authors.lastname: Sedal
authors.forename: T J
authors.initials: TJ
authors.lastname: Kilpatrick
authors.forename: H
authors.initials: H
authors.lastname: Butzkueven
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000187:drug effects*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000473:pathology; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone