Seroreversion of HIV antibodies in patients with prolonged suppression of viraemia under HAART.
Prolonged virus suppression in chronically HIV-infected patients could hypothetically lead to antibody seroreversion. Eighty-four HIV-positive individuals with undetectable viraemia for longer than 5 years under HAART were examined. Only one individual, who had initiated HAART shortly after primary HIV infection, showed seroreversion. In contrast, the cure of hepatitis C virus (HCV) with interferon in 25 controls led to the loss of HCV antibodies in most cases. This information indirectly reflects that whereas HCV may be eradicable HIV is not.
Amor
Aranzazu
A
Service of Microbiology, Hospital Carlos III, Madrid, Spain.
Toro
Carlos
C
Jiménez
Victoria
V
Simón
Ainhoa
A
Ramos
Belén
B
Soriano
Vincent
V
D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014766:Viremia / Q000188:drug therapy* / Q000276:immunology / Q000821:virology
D015483:HIV Antibodies