Effect of physical training on insulin resistance in patients with chronic heart failure.
BACKGROUND
The effect of physical training on insulin resistance (IR) in chronic heart failure (CHF) remains unclear.


RESULTS
Fourteen patients with CHF performed physical training using a bicycle ergometer; 9 patients (64%) were hyperinsulinemic and insulin resistant (HOMA IR > 1.97). Exercise tolerance increased (5.1 +/- 1.7 to 6.9 +/- 2.7 METs, p < 0.05) and heart rate at rest decreased (82 +/- 15 to 72 +/- 6, p < 0.05) in the IR group after physical training. Physical training also decreased the insulin level (15.1 +/- 5.6 to 9.8 +/- 2.6 microU/ml, p < 0.05) and HOMA IR (3.7 +/- 1.4 to 2.3 +/- 0.6, p < 0.05) in the IR group, but not in the 5 patients (36%) without IR or in 6 control patients.


CONCLUSIONS
Physical training can improve hyperinsulinemia and IR in patients with CHF.
Nishiyama
Yasuhiro
Y
Division of Cardiology, Kurume University Medical Center, Kurume, Japan.
Minohara
Motooki
M
Ohe
Masatugu
M
Hirai
Yuji
Y
Katoh
Atsushi
A
Miyamoto
Tetsuya
T
Iwami
Gensyo
G
Nakata
Masashi
M
Koga
Yoshinori
Y
D000328:Adult; D002908:Chronic Disease; D015444:Exercise; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D007328:Insulin