Antibacterial activity of YC-20, a new oxazolidinone.
OBJECTIVE
YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined.


RESULTS
YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid.


CONCLUSIONS
This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.
Cui
Yingjie
Y
Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences Shanghai 201203, China. cuiyingjie@yahoo.com
Dang
Yaxian
Y
Yang
Yushe
Y
Zhang
Shuhua
S
Ji
Ruyun
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; C515253:YC-20 compound