title: K(v)7 channels: function, pharmacology and channel modulators.
abstract: K(v)7 channels are unique among K(+) channels, since four out of the five channel subtypes have well-documented roles in the development of human diseases. They have distinct physiological functions in the heart and in the nervous system, which can be ascribed to their voltage-gating properties. The K(v)7 channels also lend themselves to pharmacological modulation, and synthetic openers as well as blockers of the channels, regulating neuronal excitability, have existed even before the K(v)7 channels were identified by cloning. In the present review we give an account on the focused efforts to develop selective modulators, openers as well as blockers, of the K(v)7 channel subtypes, which have been undertaken during recent years, along with a discussion of the K(v)7 ion channel physiology and therapeutic indications for modulators of the neuronal K(v)7 channels.
authors.affiliation: NeuroSearch A/S, DK-2750 Ballerup, Denmark. wdb@neurosearch.dk
authors.forename: William
authors.initials: W
authors.lastname: Dalby-Brown
authors.forename: Henrik H
authors.initials: HH
authors.lastname: Hansen
authors.forename: Mads P G
authors.initials: MP
authors.lastname: Korsgaard
authors.forename: Naheed
authors.initials: N
authors.lastname: Mirza
authors.forename: Søren-P
authors.initials: SP
authors.lastname: Olesen
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D001921:Brain / Q000378:metabolism; D006801:Humans; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D011336:Probability
chemical_list: D015221:Potassium Channels