title: Outcomes of an effectiveness trial of cognitive-behavioural intervention by mental health nurses in schizophrenia.
abstract: BACKGROUND
  Little is known about the medium-term durability of cognitive-behavioural therapy (CBT) in a community sample of people with schizophrenia.
  
  
  OBJECTIVE
  To investigate whether brief CBT produces clinically important outcomes in relation to recovery, symptom burden and readmission to hospital in people with schizophrenia at 1-year follow-up.
  
  
  METHODS
  Participants (336 of 422 randomised at baseline) were followed up at a mean of 388 days (s.d. = 53) by raters masked to treatment allocation (CBT or usual care).
  
  
  RESULTS
  At 1-year follow-up, participants who received CBT had significantly more insight (P = 0.021) and significantly fewer negative symptoms (P = 0.002). Brief therapy protected against depression with improving insight and against relapse; significantly reduced time spent in hospital for those who did relapse and delayed time to admission. It did not improve psychotic symptoms or occupational recovery, nor have a lasting effect on overall symptoms or depression at follow-up.
  
  
  CONCLUSIONS
  Mental health nurses should be trained in brief CBT for schizophrenia to supplement case management, family interventions and expert therapy for treatment resistance.
authors.affiliation: School of Neurology, Neurosciences and Psychiatry, Royal Victoria Infirmary, Richardson Road, Newcastle upon Tyne NE1 4LP. douglas.s.turkington@ncl.ac.uk
authors.forename: Douglas
authors.initials: D
authors.lastname: Turkington
authors.forename: David
authors.initials: D
authors.lastname: Kingdon
authors.forename: Shanaya
authors.initials: S
authors.lastname: Rathod
authors.forename: Katie
authors.initials: K
authors.lastname: Hammond
authors.forename: Jeremy
authors.initials: J
authors.lastname: Pelton
authors.forename: Raj
authors.initials: R
authors.lastname: Mehta
mesh_terms: D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003152:Community Health Nursing / Q000379:methods; D003158:Community Psychiatry / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D010359:Patient Readmission; D011568:Psychiatric Nursing; D011614:Psychotherapy, Brief / Q000379:methods; D012008:Recurrence; D012559:Schizophrenia / Q000451:nursing / Q000628:therapy*; D012565:Schizophrenic Psychology; D016037:Single-Blind Method; D016896:Treatment Outcome