title: Mitochondrial potassium channels: from pharmacology to function.
abstract: Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances.
authors.affiliation: Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur st., 02-093 Warsaw, Poland. adam@nencki.gov.pl
authors.forename: Adam
authors.initials: A
authors.lastname: Szewczyk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Skalska
authors.forename: Marta
authors.initials: M
authors.lastname: Głab
authors.forename: Bogusz
authors.initials: B
authors.lastname: Kulawiak
authors.forename: Dominika
authors.initials: D
authors.lastname: Malińska
authors.forename: Izabela
authors.initials: I
authors.lastname: Koszela-Piotrowska
authors.forename: Wolfram S
authors.initials: WS
authors.lastname: Kunz
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists / Q000502:physiology*; D024681:Potassium Channels, Calcium-Activated / Q000819:agonists / Q000037:antagonists & inhibitors; D024642:Potassium Channels, Voltage-Gated / Q000819:agonists / Q000037:antagonists & inhibitors
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D024642:Potassium Channels, Voltage-Gated; D000255:Adenosine Triphosphate; D002118:Calcium