Ovarian enzyme activities in women with polycystic ovary syndrome.
Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.
Magoffin
Denis A
DA
Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA. magoffin@cshs.org
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000328:Adult; D001141:Aromatase / Q000378:metabolism*; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000378:metabolism*; D005260:Female; D006107:Granulosa Cells / Q000201:enzymology; D006801:Humans; D010053:Ovary / Q000201:enzymology* / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000201:enzymology* / Q000473:pathology; D013799:Theca Cells / Q000201:enzymology
D001141:Aromatase; D002786:Cholesterol Side-Chain Cleavage Enzyme; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase