Results of radiotherapy in primary cutaneous lymphoma.
BACKGROUND
Multiple therapeutic strategies have been proposed for the management of primary cutaneous lymphomas. We report the outcome data and therapeutic response of a group of patients treated with local radiotherapy.


METHODS
Twenty seven patients with diagnostic of cutaneous lymphoma and treated with local radiation were evaluated for clinical response. Thirteen cases corresponded to cutaneous T-cell lymphomas (CTCL) and 14 to cutaneous B-cell lymphomas (CBCL). Orthovoltage radiotherapy of 100 Kv was used and total dose of radiation ranged from 15 to 30 Gy (mean 24 Gy; median 20 Gy).


RESULTS
The immediate response to the treatment was satisfactory in all cases. In 24 patients (89%) complete response was obtained in the irradiated lesion and in 3 cases (11%) the response was partial. With a mean follow-up of 25.4 months (range 1-100 months) the overall response rate was 96.3%. Fourteen patients (52%) were alive without evidence of disease (6 CTCL and 8 CBCL), 5 patients (18%) retained cutaneous disease or had systemic progression (3 CTCL and 2 CBCL) and 8 patients died (30%). In 7 patients lymphoma progression was the factor leading to death (26%) and in one patient the cause was not related with the disease.


CONCLUSIONS
Radiotherapy was demonstrated to be able to induce clinical remission of primary cutaneous lymphomas.
Conill
Carlos
C
Department of Radiation Oncology, Hospital Clíni, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain. cconill@clinic.ub.es
Navalpotro
Begoña
B
López
Ingrid
I
Estrach
Teresa
T
D000328:Adult; D000368:Aged; D002423:Cause of Death; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D016410:Lymphoma, T-Cell, Cutaneous / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D011879:Radiotherapy Dosage; D018401:Sample Size; D012878:Skin Neoplasms / Q000532:radiotherapy*; D016019:Survival Analysis; D016896:Treatment Outcome