title: Relationship between lung cancer and human papillomavirus in north of Iran, Mazandaran province.
abstract: Lung cancer is a major health problem and the leading cause of cancer deaths in the world. The pathogenesis of lung cancer is complex, and is believed to be due to the interaction between environmental and genetic factors. Various evidences show that HPV might be involved in bronchial carcinogenesis. In this study, 141 lung cancer patients and 92 non-cancer control subjects were enrolled to examine whether HPV DNA existed in lung tumor and normal tissues in Mazandaran, north part of Iran by nested PCR. Our data showed that 33 of 129 lung tumors had HPV DNA compared with 8 of 90 non-cancer control subjects (25.6% vs. 9.0%, P=0.002). The infection of HPV had an OR of 3.48 (95% CI 1.522-7.958; P=0.002). Meanwhile infection of high risk HPV types (16 and 18) had a significantly high OR of lung cancer incidence as 8.00 (95% CI 1.425-44.920; P=0.021) compared with 4.423 (95% CI 2.407-8.126; P0.0001) of smoking status. This result suggests that HPV infection is associated with lung cancer development in Mazandaran, Iran.
authors.affiliation: Virology Division, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. sarnadji@razi.tums.ac.ir
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Nadji
authors.forename: Talat
authors.initials: T
authors.lastname: Mokhtari-Azad
authors.forename: Mahmood
authors.initials: M
authors.lastname: Mahmoodi
authors.forename: Yousef
authors.initials: Y
authors.lastname: Yahyapour
authors.forename: Farshad
authors.initials: F
authors.lastname: Naghshvar
authors.forename: Jila
authors.initials: J
authors.lastname: Torabizadeh
authors.forename: Abed Ali
authors.initials: AA
authors.lastname: Ziaee
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000453:epidemiology; D018288:Carcinoma, Small Cell / Q000150:complications / Q000453:epidemiology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008175:Lung Neoplasms / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral