Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori.
Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.
Colbeck
Jeffrey C
JC
Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA.
Hansen
Lori M
LM
Fong
Julie M
JM
Solnick
Jay V
JV
D018829:Adhesins, Bacterial / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D001422:Bacterial Adhesion / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D020869:Gene Expression Profiling; D014644:Genetic Variation; D005838:Genotype; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data
D018829:Adhesins, Bacterial; C400429:BabA protein, Helicobacter pylori; C451032:BabB protein, Helicobacter pylori; D001425:Bacterial Outer Membrane Proteins