Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43.
The close genetic and antigenic relatedness among the group 2 coronaviruses human coronavirus OC43 (HCoV-OC43), bovine coronavirus (BCoV), and porcine hemagglutinating encephalomyelitis virus (PHEV) suggests that these three viruses with different host specificities diverged fairly recently. In this study, we determined the complete genomic sequence of PHEV (strain PHEV-VW572), revealing the presence of a truncated group 2-specific ns2 gene in PHEV in comparison to other group 2 coronaviruses. Using a relaxed molecular clock approach, we reconstructed the evolutionary relationships between PHEV, BCoV, and HCoV-OC43 in real-time units, which indicated relatively recent common ancestors for these species-specific coronaviruses.
Vijgen
Leen
L
Laboratory of Clinical and Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Keyaerts
Els
E
Lemey
Philippe
P
Maes
Piet
P
Van Reeth
Kristien
K
Nauwynck
Hans
H
Pensaert
Maurice
M
Van Ranst
Marc
M
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology; D002417:Cattle; D028962:Coronavirus OC43, Human / Q000235:genetics* / Q000276:immunology; D017938:Coronavirus, Bovine / Q000235:genetics* / Q000276:immunology; D019143:Evolution, Molecular; D016679:Genome, Viral / Q000235:genetics* / Q000276:immunology; D006801:Humans; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D013552:Swine
D000956:Antigens, Viral