[Thrombocytopenia as a complication of nonsteroidal anti-inflammatory drug treatment].
Thrombocytopenia can be a severe complication of nonsteroidal anti-inflammatory drug treatment. We report a case of a 58 year old patient who developed severe thrombocytopenia during treatment with ketoprofen. Within several days the platelet count decreased to undetectable values in routine blood count. In parallel, symptoms of severe hemorrhagic diathesis occurred. Immunoenzymatic tests and result of bone marrow trepanobiopsy ruled out underlying cancer and idiopathic thrombocytopenic purpura (antiplatelet antibodies were not detected). After discontinuation of ketoprofen and treatment with corticosteroids, the patient's platelet count returned to normal and remained stable at 6 months of follow-up.
Luba
Maria
M
Oddział Chorób Wewnetrznych, Szpitala SP ZOZ w Rabce-Zdroju. marialuba@poczta.onet.pl
Gusarski
Igor
I
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010976:Platelet Count; D012074:Remission Induction; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D007660:Ketoprofen