Coumarin Schiff-bases: as antioxidant and possibly anti-inflammatory agents.
Coumarin Schiff-bases (CSB) possessing different substituents on the 4-methyl-2-substituted phenyl imino-2H-chromene-7-ol molecule were evaluated for their in-vitro antioxidant and plausible anti-inflammatory potential. The antioxidant studies of selected CSB were carried out by determining their reducing power, OH* radical scavenging activity, scavenging of stable 2,2-diphenyl-l-picrylhydrazine (DPPH*) radical and inhibition of the polyphenol oxidase (PPO) enzyme. The assessment of possible anti-inflammatory potential was performed by trypsin inhibition assay and inhibition of beta-glucuronidase. All the CSBs under study showed significant reducing effects. The majority of the tested CSB were found to be effective scavengers of DPPH* radical with moderate to low OH* scavenging ability and significantly inhibited the activity of PPO. With few exceptions, results from the inhibition assay of trypsin and beta-glucuronidase were not encouraging, however they may be helpful in defining structure-activity relationships in further optimization of the lead molecules.
Gacche
R N
RN
School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded-431606 (MS), India. rngacche@rediffmail.com
Gond
D S
DS
Dhole
N A
NA
Dawane
B S
BS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000925:Anticoagulants / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005966:Glucuronidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D010084:Oxidation-Reduction; D010851:Picrates; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D000975:Antioxidants; D001713:Biphenyl Compounds; D003374:Coumarins; D016166:Free Radical Scavengers; D010851:Picrates; D012545:Schiff Bases; D017665:Hydroxyl Radical; C030123:coumarin; C004931:1,1-diphenyl-2-picrylhydrazyl; D004156:Catechol Oxidase; D005966:Glucuronidase; D014357:Trypsin