Comparison of the effects of di(2-ethylhexyl)phthalate, a peroxisome proliferator, on the vitamin metabolism involved in the energy formation in rats fed with a casein or gluten diet.
In order to find an alleviation method for the adverse effect of environmental endocrine disrupters, we studied the effects of the putative endocrine disrupter and peroxisome proliferator, di(2-ethylhexyl)phthalate (DEHP), on animal growth and vitamin metabolism. It is known that the effects of chemical compounds such as xenobiotics differ according to the dietary protein source. We compared the effects of dietary DEHP administration on rats fed with a diet containing milk casein or wheat gluten. The increased conversion ratio of tryptophan to nicotinamide by DEHP administration was significantly higher in the casein group than in the gluten group. We also investigated the effects of DEHP on the urinary excretion of other vitamins. DEHP administration resulted in decreased urinary excretion of vitamin B(1), vitamin B(2), and pantothenic acid.
Shibata
Katsumi
K
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga. kshibata@shc.usp.ac.jp
Fukuwatari
Tsutomu
T
Iguchi
Yoriko
Y
Kurata
Yuko
Y
Sudo
Miki
M
Sasaki
Ryuzo
R
D000821:Animal Feed; D000818:Animals; D001066:Appetite; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005983:Glutens / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D020025:Peroxisome Proliferators / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014364:Tryptophan / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism*
D002364:Caseins; D020025:Peroxisome Proliferators; D014815:Vitamins; D005983:Glutens; D014364:Tryptophan; D004051:Diethylhexyl Phthalate