[The total antioxidative activity measured by FRAP method in women with intrauterine growth restriction treated by L-arginine].
The total antioxidative activity means the organisms ability to defend against free radical reactions. This can be changed in pathological pregnancies.


METHODS
The aim of the study was to find the correlation between total antioxidative activity in the serum of healthy pregnant women and in intrauterine growth restriction. The decrease of total antioxidative activity may be connected with high risk of cell membrane destruction. High risk of destruction of different biological cell functions by free radical processes is observed in IUGR and hypertension.


METHODS
The study was taken in Medical University in Lodz in 1999-2003. The study group consists of 80 women with IUGR, the controls of 60 healthy pregnant women. L-arginine - nitric oxide precursor and acetylsalicylic acid were used in the group of IUGR. The total antioxidative serum activity was measured by FRAP method and expressed in mmol/l.


RESULTS
In IUGR group total antioxidative activity was lower before treatment and it increases after the treatment. In controls, the value was higher than in IUGR group before and after the treatment.


CONCLUSIONS
The significant difference between two groups and the increase of total antioxidative activity in IUGR due to the L-arginine treatment was found.
Karowicz-Bilińska
Agata
A
Klinika Patologii Ciazy I Katedry Ginekologii i Połoznictwa Uniwersytetu Medycznego w Lodzi.
Kuś
Ewa
E
Kowalska-Koprek
Urszula
U
D000328:Adult; D001120:Arginine / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011044:Poland; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000378:metabolism*; D012189:Retrospective Studies; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D001241:Aspirin