title: Radioguided occult lesion localisation in combination with detection of the sentinel lymph node in non-palpable breast cancer tumours.
abstract: OBJECTIVE
  The aim of study was to determine the efficacy of radioguided occult lesion localisation (ROLL) for non-palpable invasive breast cancer combined with sentinel lymph node biopsy (SLNB) and to compare the amount of tissue excised by radioguided navigation versus the hook-wire technique.
  
  
  METHODS
  We injected 45 MBq of radiolabelled technetium intratumourally and 15 MBq subdermally 18 hours before surgery in 21 women with bioptically verified non-palpable breast cancer. We identified by gamma probe non-palpable tumours, which were excised, followed by identification and excision of the sentinel lymph node. We compared our results with a group of 12 women with non-palpable lesions marked by hook-wire localisation.
  
  
  RESULTS
  ROLL combined with SLNB was successful in 100%; volume of excised tissue was smaller in the hook-wire group but expressed higher variability in volume than in the ROLL group although the difference was not statistically significant.
  
  
  CONCLUSIONS
  The method of ROLL combined with SLNB is technically possible and safe, resulting in minimisation of the surgical intervention and a decrease in postoperative morbidity. ROLL was more precise than the hook-wire procedure even though the amount of tissue excised was the same in both groups.
authors.affiliation: Department of Obstetrics and Gynaecology, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Strnad
authors.forename: L
authors.initials: L
authors.lastname: Rob
authors.forename: M G
authors.initials: MG
authors.lastname: Halaska
authors.forename: J
authors.initials: J
authors.lastname: Chod
authors.forename: A
authors.initials: A
authors.lastname: Zuntova
authors.forename: Z
authors.initials: Z
authors.lastname: Moravcova
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D021701:Sentinel Lymph Node Biopsy; D017556:Technetium Compounds
chemical_list: D019275:Radiopharmaceuticals; D017556:Technetium Compounds