title: Capillary electrophoresis for the analysis of small-molecule pharmaceuticals.
abstract: This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.
authors.affiliation: GlaxoSmithKline Research & Development, Harlow, Essex, UK. kevin.d.altria@gsk.com
authors.forename: Kevin
authors.initials: K
authors.lastname: Altria
authors.forename: Alex
authors.initials: A
authors.lastname: Marsh
authors.forename: Cari
authors.initials: C
authors.lastname: Sänger-van de Griend
mesh_terms: D002845:Chromatography; D004340:Drug Contamination; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations