title: Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy.
abstract: To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 to 14.1 years). Fifty-three percent of patients were seizure free at 10 years. The authors identified multiple predictors of recurrence. Results of EEG performed 6 months postoperatively correlated with occurrence and severity of seizure recurrence, in addition to breakthrough seizures with discontinuation of antiepileptic drugs.
authors.affiliation: Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. jehil@ccf.org
authors.forename: L E
authors.initials: LE
authors.lastname: Jeha
authors.forename: I M
authors.initials: IM
authors.lastname: Najm
authors.forename: W E
authors.initials: WE
authors.lastname: Bingaman
authors.forename: F
authors.initials: F
authors.lastname: Khandwala
authors.forename: P
authors.initials: P
authors.lastname: Widdess-Walsh
authors.forename: H H
authors.initials: HH
authors.lastname: Morris
authors.forename: D S
authors.initials: DS
authors.lastname: Dinner
authors.forename: D
authors.initials: D
authors.lastname: Nair
authors.forename: N
authors.initials: N
authors.lastname: Foldvary-Schaeffer
authors.forename: R A
authors.initials: RA
authors.lastname: Prayson
authors.forename: Y
authors.initials: Y
authors.lastname: Comair
authors.forename: R
authors.initials: R
authors.lastname: O'Brien
authors.forename: J
authors.initials: J
authors.lastname: Bulacio
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: H O
authors.initials: HO
authors.lastname: Lüders
mesh_terms: D038481:Anterior Temporal Lobectomy / Q000706:statistics & numerical data*; D000927:Anticonvulsants / Q000627:therapeutic use; D002908:Chronic Disease; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D055502:Secondary Prevention; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000601:surgery; D017211:Treatment Failure; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000927:Anticonvulsants