title: CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor.
abstract: The physiological significance of calcitonin gene-related peptide (CGRP) during biomineralization was investigated by assessing the effect of human CGRP on the carbonic anhydrase activity in gill membranes of the pearl oyster, Pinctada margaritifera. Salmon CT and human CGRP were able to induce a 150% increase of the basal activity. No additive effect was observed suggesting that both activities are mediated by the same receptor. The CGRP-stimulated effect was specific as demonstrated by the inhibition produced by the CGRP antagonist, hCGRP8-37. So, CGRP by its specific action on gill carbonic anhydrase controls the calcification process, an ancient role both in invertebrates and non-mammalian vertebrates.
authors.affiliation: UMR 5178 CNRS/MNHN/UPMC, Muséum National d'Histoire Naturelle, Station Biologie Marine, 29900 Concarneau, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Cudennec
authors.forename: Marthe
authors.initials: M
authors.lastname: Rousseau
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lopez
authors.forename: Martine
authors.initials: M
authors.lastname: Fouchereau-Peron
mesh_terms: D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects / Q000502:physiology; D002116:Calcitonin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology / Q000502:physiology*; D002256:Carbonic Anhydrases / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005880:Gills / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology; D049911:Pinctada / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D012474:Salmon; D013997:Time Factors
chemical_list: D010446:Peptide Fragments; D018015:Receptors, Calcitonin Gene-Related Peptide; C058636:calcitonin gene-related peptide (8-37); C087166:AC 187; D002116:Calcitonin; D002256:Carbonic Anhydrases; D015740:Calcitonin Gene-Related Peptide