title: Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials.
abstract: Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.
authors.affiliation: Departamento de Química Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Balas
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzano
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D000327:Adsorption; D019386:Alendronate / Q000737:chemistry*; D050071:Bone Density Conservation Agents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D050071:Bone Density Conservation Agents; D004337:Drug Carriers; D063065:Organophosphonates; D012822:Silicon Dioxide; D019386:Alendronate