title: Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero.
abstract: BACKGROUND
  Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early spontaneous pregnancy loss, ectopic gestation and infertility.
  
  
  METHODS
  A 34-year old woman with a 6-year history of primary infertility is presented. The patient underwent in vitro fertilization (IVF) treatment without success. To improve the quality of the endometrium following IVF treatment, E2 and progesterone supplementation was added to the usual therapeutic regimen. The pregnancy progressed uneventfully and a normal female was born.
  
  
  CONCLUSIONS
  This case indicates that the administration of E2 and progesterone in DES-exposed women might improve endometrium receptivity and consequently pregnancy outcome.
authors.affiliation: First Department of Obstetrics and Gynaecology, Athens University School of Medicine, Alexandra Hospital, Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Loutradis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stefanidis
authors.forename: Erasmia
authors.initials: E
authors.lastname: Kiapekou
authors.forename: Evangelia
authors.initials: E
authors.lastname: Zapanti
authors.forename: Chrisoula
authors.initials: C
authors.lastname: Panitsa-Faflia
authors.forename: Aristidis
authors.initials: A
authors.lastname: Antsaklis
mesh_terms: D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004717:Endometrium / Q000187:drug effects*; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000379:methods; D007246:Infertility / Q000139:chemically induced / Q000188:drug therapy; D008183:Luteal Phase / Q000187:drug effects*; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy*; D011374:Progesterone / Q000627:therapeutic use*
chemical_list: D011374:Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol