title: Significance of small dense low-density lipoprotein as a risk factor for coronary artery disease and acute coronary syndrome.
abstract: Small dense LDL (sd-LDL) has recently emerged as an important coronary artery disease (CAD) risk factor. This study was performed to investigate how LDL particle size is related to CAD and acute coronary syndrome (ACS). Blood samples were collected from 504 patients that underwent coronary angiography to evaluate chest pain. The LDL particle size of these samples was measured. The mean LDL particle size was smaller in patients with angiographically proven CAD than in the controls (26.41 +/- 0.95 vs 26.73 +/- 0.64 nm, p < 0.001), and was negatively correlated with the Framingham risk score (r=-0.121, p=0.007). Patients with more extensive CAD had smaller LDL particles. LDL particle size was also smaller in patients with acute coronary syndrome as compared to non-ACS patients (26.09 +/- 1.42 vs 26.54 +/- 0.63 nm, p=0.011). These results suggest that sd-LDL is independently associated with the incidence and extent of CAD, and can be a risk factor for the development of ACS in the Korean population.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Kangnam-gu, Seoul 135-720, Korea.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Kwon
authors.forename: Se-Jung
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Tae Soo
authors.initials: TS
authors.lastname: Kang
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Jihyuk
authors.initials: J
authors.lastname: Rhee
authors.forename: Sung-Ju
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jong-Kwan
authors.initials: JK
authors.lastname: Park
authors.forename: Jae Yun
authors.initials: JY
authors.lastname: Lim
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Bum Kee
authors.initials: BK
authors.lastname: Hong
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL