title: Mitochondrial disease in adults: a scale to monitor progression and treatment.
abstract: The natural history of mitochondrial diseases is poorly understood, limiting our ability to offer prognostic advice to patients or to evaluate therapy. One major obstacle to improving our understanding is the lack of a clinical rating scale to monitor the extensive clinical spectrum of mitochondrial disease. In this article, the authors describe the development and validation of a practical and semiquantitative rating scale, the Newcastle Mitochondrial Disease Adult Scale.
authors.affiliation: Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
authors.forename: A M
authors.initials: AM
authors.lastname: Schaefer
authors.forename: C
authors.initials: C
authors.lastname: Phoenix
authors.forename: J L
authors.initials: JL
authors.lastname: Elson
authors.forename: R
authors.initials: R
authors.lastname: McFarland
authors.forename: P F
authors.initials: PF
authors.lastname: Chinnery
authors.forename: D M
authors.initials: DM
authors.lastname: Turnbull
mesh_terms: D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000628:therapy*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D016896:Treatment Outcome