Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report.
OBJECTIVE
To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers.


METHODS
We evaluated 9 nondiabetic patients aged 26.6 years (median 26 years, range 17 to 41 years) and matched volunteers, using the frequently sampled intravenous glucose tolerance test, minimal model analysis, and fasting adiponectin levels.


RESULTS
The mean insulin sensitivity index of the patients was 42% lower than that of the healthy volunteers (P = 0.026), with inadequate compensation in insulin secretion. Patients with schizophrenia tended to have reduced adiponectin levels (P = 0.055).


CONCLUSIONS
By direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs.
Cohn
Tony A
TA
Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario. Tony_Cohn@camh.net
Remington
Gary
G
Zipursky
Robert B
RB
Azad
Azar
A
Connolly
Philip
P
Wolever
Thomas M S
TM
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009864:Ontario; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
D052242:Adiponectin