[Histopathologic study of the ethmoid bone in chronic sinusitis].
OBJECTIVE
To investigate the histopathologic study of the ethmoid bone in chronic sinusitis (CRS) and the role of bone pathology in the pathogenesis of CRS.


METHODS
Specimens of mucosa of ethmoid sinus with bone were collected during operation from 40 patients with CRS, 25 males and 15 females, aged 44.8, and specimens of mucosa of ethmoid sinus were collected from 16 patients with other otorhinolaryngologic diseases, 9 males and 7 females, aged 40.9 during operation. The specimens underwent HE, tartrate-resistant acid phosphatase, alkaline phosphatase, and Van Gieson staining so as to obtain the scores of nasal mucosa inflammation, pathology of mucoperiosteum and bone, and activity of bone remodeling.


RESULTS
The average score of mucosal inflammation of the CRS group was 2.30 +/- 0.88, significantly higher than that of the control group (1.38 +/- 0.81, P = 0.004). The score of mucoperiosteum and bone pathology of the CRS group was 1.65 +/- 0.84, significantly higher than that of the control group (1.00 +/- 0.73, P = 0.004). The score of bone remodeling activity of the CRS group was 2.15 +/- 0.74, significantly higher than that of the control group (1.56 +/- 0.63, P = 0.007). In the CRS patients, the score of mucosal inflammation was not significantly correlated with the mucoperiosteum and bone pathology (R = 0.047, P = 0.772), and the activity of bone remodeling (R = 0.021, P = 0.897).


CONCLUSIONS
The ethmoid bone of CRS patients shows marked fibrosis, bone remodeling, structure of woven bone, and pathologic changes similar to those of chronic osteomyelitis, especially bone absorption, new bone formation, etc.
Wang
Tong
T
Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Affiliated to Capital University of Medical Sciences, Beijing 100730, China. wangtongent@tom.com
Han
De-Min
DM
Zhou
Bing
B
Cui
Shun-Jiu
SJ
Fan
Er-Zhong
EZ
Li
Ying
Y
D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D002908:Chronic Disease; D005004:Ethmoid Bone / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009295:Nasal Bone / Q000473:pathology*; D009297:Nasal Mucosa / Q000201:enzymology / Q000473:pathology; D010019:Osteomyelitis / Q000473:pathology; D012852:Sinusitis / Q000473:pathology*; D000071681:Tartrate-Resistant Acid Phosphatase
D007527:Isoenzymes; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase