title: [Severe ocular side effects with Topamax].
abstract: METHODS
  We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks.
  
  
  CONCLUSIONS
  We identified two severe ocular adverse reactions from topiramate. Both reactions necessitated discontinuing the treatment, but the topiramate-associated maculopathy was irreversible.
authors.affiliation: Hospital General, Medina del Campo, Valladolid, España. vasensio@hmdc.sacyl.es
authors.forename: V M
authors.initials: VM
authors.lastname: Asensio-Sánchez
authors.forename: B
authors.initials: B
authors.lastname: Torreblanca-Agüera
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Calvo
authors.forename: M J
authors.initials: MJ
authors.lastname: Calvo
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001766:Blindness / Q000139:chemically induced*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006423:Hemianopsia / Q000139:chemically induced*; D006801:Humans; D008266:Macula Lutea; D012164:Retinal Diseases / Q000139:chemically induced*; D000077236:Topiramate; D014794:Visual Fields
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose