title: Combined local treatment and chemotherapy in the management of bilateral retinoblastomas in Hungary.
abstract: This retrospective study supports that brachytherapy combined with cytostatic therapy may effectively contribute to tumor control. The second eye of 13 patients with bilateral retinoblastoma was treated with plaque brachytherapy after the enucleation of the first eye. Eleven patients received systemic cytostatic therapy. The mean follow up was 60 (+/-42 SD) months. Twelve patients are alive and free of tumor, 8 of them with acceptable visual acuity. After cytostatic therapy, late nephropathy was observed in 2 patients. In conclusion, brachytherapy combined with cytostatic therapy will be an option in the management of bilateral retinoblastoma after the enucleation of the first eye.
authors.affiliation: Departments of Ophthalmology, University of Debrecen, Debrecen, Hungary. zoltansohajda@hotmail.com
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sohajda
authors.forename: Judit
authors.initials: J
authors.lastname: Damjanovich
authors.forename: Edit
authors.initials: E
authors.lastname: Bárdi
authors.forename: István
authors.initials: I
authors.lastname: Szegedi
authors.forename: András
authors.initials: A
authors.lastname: Berta
authors.forename: Csongor
authors.initials: C
authors.lastname: Kiss
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001918:Brachytherapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D020127:Recovery of Function; D019572:Retinal Neoplasms / Q000150:complications / Q000628:therapy*; D012175:Retinoblastoma / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies