title: Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs.
abstract: The antitussive activity of Crocus sativus stigma and petal extracts and its components, safranal and crocin, was evaluated using the nebolized solution of citric acid 20% in guinea pigs. The extract and agents were injected intraperitoneally. The ethanolic extract of C. sativus (100-800 mg/kg) and safranal (0.25-0.75 ml/kg) reduced the number of cough. The ethanolic and aqueous extracts of petal and crocin did not show antitussive activity.
authors.affiliation: Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR, Iran. hosseinzadehh@yahoo.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinzadeh
authors.forename: Jafar
authors.initials: J
authors.lastname: Ghenaati
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019343:Citric Acid; D003371:Cough / Q000188:drug therapy; D027622:Crocus; D053138:Cyclohexenes; D005260:Female; D035264:Flowers; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000996:Antitussive Agents; D053138:Cyclohexenes; D010936:Plant Extracts; D013729:Terpenes; D019343:Citric Acid; D002338:Carotenoids; C087963:safranal; C029036:crocin