Implementation of a combined association-linkage model for quantitative traits in linear mixed model procedures of statistical packages.
A transmission disequilibrium test for quantitative traits which combines association and linkage analyses is currently available in several dedicated software packages. We describe how to implement such models in linear mixed model procedures that are available in widely used statistical packages such as SPSS. We also briefly mention a few extensions of the model that become naturally available once the model is implemented in such procedures.
Beem
A Leo
AL
Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. al.beem@psy.vu.nl
Boomsma
Dorret I
DI
D004200:Diseases in Twins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016014:Linear Models; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable; D012984:Software; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics