title: Deciphering signaling control by phosphoproteome using mass spectrometry.
abstract: Analysis of changes in genes and protein profiles provides invaluable information to understand the activities and functions of proteins. However, their activities are further regulated by post-translational modifications, such as glycosylation and phosphorylation. Cell growth and apoptotic pathways are good examples of demonstrating the roles of phosphorylation in activation of protein cascades upon stimulation.
authors.affiliation: Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. leungyk@ucmail.uc.edu
authors.forename: Yuet-Kin
authors.initials: YK
authors.lastname: Leung
authors.forename: John W
authors.initials: JW
authors.lastname: Ho
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D013058:Mass Spectrometry; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry*; D020543:Proteome; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011506:Proteins; D020543:Proteome