title: Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.
abstract: Polycomb group (PcG) genes are regulators of body segmentation and cell growth, therefore being important players during development. PcG proteins form large complexes (PRC) that fulfil mostly repressive regulative functions on homeotic gene expression. Although expression of PcG genes in the brain has been noticed, the involvement of PcG genes in the processes of brain development is not understood. In this study, we analysed the expression patterns of PRC1 complex members to reveal PcG proteins that might be relevant for mouse brain development. Using in situ hybridisation, we show PRC1 activity in proliferative progenitor cells during neurogenesis, but also in maturated neuronal structures. PRC1 complex compositions vary in a spatial and temporal controlled manner during mouse brain development, providing cellular tools to act in different developmental contexts of cell proliferation, cell fate determination, and differentiation.
authors.affiliation: Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Karl-Friedrich-Bonhoeffer-Institute, Goettingen, Germany. tvogel1@gwdg.de
authors.forename: Tanja
authors.initials: T
authors.lastname: Vogel
authors.forename: Anastassia
authors.initials: A
authors.lastname: Stoykova
authors.forename: Peter
authors.initials: P
authors.lastname: Gruss
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D017403:In Situ Hybridization; D051379:Mice; D046912:Multiprotein Complexes; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D063146:Polycomb-Group Proteins; D011247:Pregnancy; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins