title: Intracoronary injection of granulocyte colony-stimulating factor ameliorates the progression of left ventricular remodeling after myocardial ischemia/reperfusion in rabbits.
abstract: BACKGROUND
  Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown.
  
  
  RESULTS
  A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection.
  
  
  CONCLUSIONS
  Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takano
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ueda
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Niitsuma
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tadokoro
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004452:Echocardiography; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications; D011817:Rabbits; D011994:Recombinant Proteins; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor