title: A brief history of RNAi: the silence of the genes.
abstract: The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.
authors.affiliation: Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr., CCSR 4225A, Stanford University School of Medicine, Stanford, California 94305, USA. gsen@stanford.edu
authors.forename: George L
authors.initials: GL
authors.lastname: Sen
authors.forename: Helen M
authors.initials: HM
authors.lastname: Blau
mesh_terms: D060565:Argonaute Proteins; D015852:Eukaryotic Initiation Factor-2; D020868:Gene Silencing; D006801:Humans; D010448:Peptide Initiation Factors / Q000235:genetics; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D043244:Ribonuclease III / Q000235:genetics
chemical_list: C466422:AGO2 protein, human; D060565:Argonaute Proteins; D015852:Eukaryotic Initiation Factor-2; D010448:Peptide Initiation Factors; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D043244:Ribonuclease III