Biology of colorectal liver metastases: A review.
Metastatic growth is a selective, non-random process, which in the case of colorectal cancer, frequently occurs in the liver and is the major cause of cancer related death in these patients. This review summarises attempts to find biological and molecular markers of metastasis and their role in establishment of secondary tumours. Recent evidence suggests that liver metastases are phenotypically different to the primary from which they were derived and thus represent a separate disease entity.
Bird
Nigel C
NC
Liver Research Group, Clinical Sciences (South), Royal Hallamshire Hospital, Sheffield, United Kingdom. n.bird@shef.ac.uk
Mangnall
David
D
Majeed
Ali W
AW
D017209:Apoptosis; D001485:Basement Membrane / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019040:E-Selectin / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D018734:Genes, erbB-2; D016259:Genes, myc; D016391:Genes, src; D006498:Hepatectomy; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008967:Molecular Biology / Q000379:methods; D009077:Mucins / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
D014408:Biomarkers, Tumor; D019040:E-Selectin; D018960:Hyaluronan Receptors; D009077:Mucins; D042442:Vascular Endothelial Growth Factors; D020782:Matrix Metalloproteinases