Membrane guanylyl cyclase receptors: an update.
Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance.
Garbers
David L
DL
Cecil H. & Ida Green Center for Reproductive Biology Sciences, and Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9051, USA. david.garbers@utsouthwestern.edu
Chrisman
Ted D
TD
Wiegn
Phi
P
Katafuchi
Takeshi
T
Albanesi
Joseph P
JP
Bielinski
Vincent
V
Barylko
Barbara
B
Redfield
Margaret M
MM
Burnett
John C
JC
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D006162:Guanylate Cyclase / Q000235:genetics; D006801:Humans; D007422:Intestines / Q000502:physiology; D008246:Lysophospholipids / Q000378:metabolism; D008954:Models, Biological; D020097:Natriuretic Peptide, Brain / Q000502:physiology; D020098:Natriuretic Peptide, C-Type / Q000502:physiology; D045265:Natriuretic Peptides / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics; D050705:Receptors, Guanylate Cyclase-Coupled / Q000502:physiology*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
D008246:Lysophospholipids; D045265:Natriuretic Peptides; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; C060506:sphingosine 1-phosphate; D009320:Atrial Natriuretic Factor; D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; D050705:Receptors, Guanylate Cyclase-Coupled; C091715:atrial natriuretic factor receptor A; D013110:Sphingosine