title: Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation.
abstract: OBJECTIVE
  To retrospectively evaluate magnetic resonance (MR) imaging-based thermometry and thermal dosimetry during focused ultrasound treatments of uterine leiomyomas (ie, fibroids).
  
  
  METHODS
  All patients gave written informed consent for the focused ultrasound treatments and the current HIPAA-compliant retrospective study, both of which were institutional review board approved. Thermometry performed during the treatments of 64 fibroids in 50 women (mean age, 46.6 years +/- 4.5 [standard deviation]) was used to create thermal dose maps. The areas that reached dose values of 240 and 18 equivalent minutes at 43 degrees C were compared with the nonperfused regions measured on contrast material-enhanced MR images by using the Bland-Altman method. Volume changes in treated fibroids after 6 months were compared with volume changes in nontreated fibroids and with MR-based thermal dose estimates.
  
  
  RESULTS
  While the thermal dose estimates were shown to have a clear relationship with resulting nonperfused regions, the nonperfused areas were, on average, larger than the dose estimates (means of 1.9 +/- 0.7 and 1.2 +/- 0.4 times as large for areas that reached 240- and 18-minute threshold dose values, respectively). Good correlation was observed for smaller treatment volumes at the lower dose threshold (mean ratio, 1.0 +/- 0.3), but for larger treatment volumes, the nonperfused region extended to locations within the fibroid that clearly were not heated. Variations in peak temperature increase were as large as a factor of two, both between patients and within individual treatments. On average, the fibroid volume reduction at 6 months increased as the ablated volume estimated by using the thermal dose increased.
  
  
  CONCLUSIONS
  Study results showed good correlation between thermal dose estimates and resulting nonperfused areas for smaller ablated volumes. For larger treatment volumes, nonperfused areas could extend within the fibroid to unheated areas.
authors.affiliation: Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Ave (LMRC, 007c), Boston, MA 02115, USA. njm@bwh.harvard.edu
authors.forename: Nathan
authors.initials: N
authors.lastname: McDannold
authors.forename: Clare M
authors.initials: CM
authors.lastname: Tempany
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Fennessy
authors.forename: Minna J
authors.initials: MJ
authors.lastname: So
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.forename: Ferenc A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000328:Adult; D001831:Body Temperature; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000628:therapy*; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012189:Retrospective Studies; D014464:Ultrasonic Therapy / Q000009:adverse effects* / Q000379:methods; D018084:Ultrasonography, Interventional; D014594:Uterine Neoplasms / Q000628:therapy*