Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice.
Many previous studies have reported that conjugated linoleic acid could be produced by starter culture bacteria, but the effects of the bacteria were not investigated. Moreover, there was no evidence of the conjugated linoleic acid-producing bacteria having potential health or nutritional effects related to conjugated linoleic acid, including reducing body fat. Here, we investigated the anti-obesity effect of Lactobacillus rhamnosus PL60, a human originated bacterium that produces t10, c12-conjugated linoleic acid, on diet-induced obese mice. After 8 weeks of feeding, L. rhamnosus PL60 reduced body weight without reducing energy intake, and caused a significant, specific reduction of white adipose tissue (epididymal and perirenal). Although the size of epididymal adipocytes was not reduced by L. rhamnosus PL60, apoptotic signals and UCP-2 mRNA levels increased in adipose tissue. Liver steatosis, a well known side effect of CLA, was not observed by L. rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect.
Lee
Hui-Young
HY
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Park
Jong-Hwan
JH
Seok
Seung-Hyeok
SH
Baek
Min-Won
MW
Kim
Dong-Jae
DJ
Lee
Ki-Eun
KE
Paek
Kyung-Soo
KS
Lee
Yeonhee
Y
Park
Jae-Hak
JH
D000818:Animals; D001691:Biological Therapy; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D002149:Energy Intake / Q000187:drug effects; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000737:chemistry / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated / Q000378:metabolism* / Q000627:therapeutic use; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D019936:Probiotics / Q000627:therapeutic use
D044243:Linoleic Acids, Conjugated