Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study.
The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders. Although IL-10 has been shown to modulate thrombin generation in several experimental models, it is not known whether IL-10 polymorphisms could be a risk factor for venous thrombosis. We therefore conducted a case-control study comparing 74 consecutive patients who experienced at least one episode of documented venous thromboembolic event and 100 healthy controls. All subjects were Caucasians. Five polymorphisms of the IL-10 promoter gene were studied: two highly polymorphic dinucleotide repeats, IL-10 R and IL-10G, and three single nucleotide polymorphisms at position -1082, -819 and -592. Factor VG1691C Leiden mutation was systematically determined. Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis (Odds ratio:OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease.
Cochery-Nouvellon
Eva
E
Laboratoire Central d'hématologie, CHU Robert Debré, Université de Reims Champagne-Ardenne, France. pnguyen@chu-reims.fr
Vitry
Fabien
F
Cornillet-Lefebvre
Pascale
P
Hezard
Nathalie
N
Gillot
Lucile
L
Nguyen
Philippe
P
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005165:Factor V; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D013923:Thromboembolism; D020246:Venous Thrombosis / Q000209:etiology / Q000235:genetics*; D044465:White People
C095381:factor V Leiden; D016753:Interleukin-10; D005165:Factor V