Interactions between glycopeptides and beta-lactams against isogenic pairs of teicoplanin-susceptible and -resistant strains of Staphylococcus haemolyticus.
Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results provided insights into the puzzling issue of antistaphylococcal interactions between glycopeptides and beta-lactams, especially the paradox of double zones around beta-lactam disks and the relationships between autolysis rate and type of interaction.
Vignaroli
Carla
C
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte d'Ago, 60131 Ancona, Italy.
Biavasco
Francesca
F
Varaldo
Pietro E
PE
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D006020:Glycopeptides / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D041162:Staphylococcus haemolyticus / Q000187:drug effects* / Q000235:genetics; D017334:Teicoplanin / Q000494:pharmacology*; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D047090:beta-Lactams; D017334:Teicoplanin