title: Muscle slowness in a family with nemaline myopathy.
abstract: All patients of a large family with nemaline myopathy complained of slowness in movement. We confirmed this clinical complaint physiologically by showing lower contractile speed in quadriceps muscle. Electrically evoked contractions of the quadriceps muscle elicited a lower rate of relaxation and a tendency for slower torque generation. Here, we demonstrate for the first time slow muscle characteristics as a physiological correlate for the clinical complaint of slowness.
authors.affiliation: Institute for Fundamental and Clinical Human Movement Sciences, Institute of Neurology, Neuromuscular Centre Nijmegen, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Inge M P
authors.initials: IM
authors.lastname: Pauw-Gommans
authors.forename: Karin H L
authors.initials: KH
authors.lastname: Gerrits
authors.forename: Arnold
authors.initials: A
authors.lastname: de Haan
authors.forename: Baziel G M
authors.initials: BG
authors.lastname: van Engelen
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D004558:Electric Stimulation; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007537:Isometric Contraction / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D017696:Myopathies, Nemaline / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D009460:Neurologic Examination; D052097:Quadriceps Muscle / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011930:Reaction Time / Q000235:genetics; D013997:Time Factors; D019415:Torque