title: Some toxicological studies of Momordica charantia L. on albino rats in normal and alloxan diabetic rats.
abstract: Momordica charantia L. (MC) (Cucurbitaceae) commonly known as balsam pear, bitter gourd or karela, used in several purposes in traditional medicine is an important medicinal plant. Two sets of experiments were carried out, the first experiment indicated that the LD(50) for MC juice and alcoholic extracts were 91.9 and 362.34 mg/100g b.wt., respectively, of subcutaneously "s.c." injected mice. The toxic signs were recorded within the first 24 h post-injection. The second experiment was performed to evaluate the effect of MC juice and alcoholic extracts on blood glucose and other biochemical parameters in normal and diabetic rats. Both extracts induced a significant decrease in serum glucose levels in normal and diabetic rats. The two extracts did not show any significant effect in urea, creatinine, ALT, AST and AP in normal rat, while in diabetic rats the two extracts caused a significant decrease in serum urea, creatinine, ALT, AST, AP, cholesterol and triglyceride levels. Also, these results suggested that MC extracts possesses anti-diabetic, hepato-renal protective and hypolipidemic effect in alloxan-induced diabetic rats. Thus, MC is alternative therapy that has primarily been used for lowering blood glucose levels in patients with diabetes mellitus.
authors.affiliation: Pharmacology Department, National Research Center, Dokki, Giza, Egypt.
authors.forename: Seham
authors.initials: S
authors.lastname: Abd El Sattar El Batran
authors.forename: Souad E
authors.initials: SE
authors.lastname: El-Gengaihi
authors.forename: Osama A
authors.initials: OA
authors.lastname: El Shabrawy
mesh_terms: D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D000496:Alloxan; D000818:Animals; D000924:Anticholesteremic Agents / Q000302:isolation & purification / Q000627:therapeutic use / Q000633:toxicity; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D005638:Fruit; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000924:Anticholesteremic Agents; D001786:Blood Glucose; D010936:Plant Extracts; D014280:Triglycerides; D000431:Ethanol; D000496:Alloxan; D002784:Cholesterol; D003404:Creatinine; D000637:Transaminases; D000469:Alkaline Phosphatase