title: p53 aerobics: the major tumor suppressor fuels your workout.
abstract: In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.
authors.affiliation: Institute for Cancer Genetics, and Department of Pathology, College of Physicians & Surgeons, Columbia University, 1150 St. Nicholas Ave, New York, New York 10032, USA.
authors.forename: Jan-Philipp
authors.initials: JP
authors.lastname: Kruse
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
mesh_terms: D000332:Aerobiosis; D000818:Animals; D002352:Carrier Proteins; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D006019:Glycolysis; D006801:Humans; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D010101:Oxygen Consumption / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D011506:Proteins; C400285:SCO2 protein, human; C511423:SCO2 protein, mouse; D016159:Tumor Suppressor Protein p53; D003576:Electron Transport Complex IV