[Effects of vitamin D on the cardiovascular system].
Active vitamin D plays important roles not only in bone and mineral metabolism but also in the cardiovascular system. Cohort studies in hemodialysis patients demonstrated that use of active vitamin D analogs was associated with reduced risk of death, particularly death from cardiovascular disease. Treatment with vitamin D had beneficial effects on cardiac and immune functions in dialysis patients, and inflammatory markers in non-renal subjects. Also, anti-proteinuric effect was recently shown in chronic kidney disease. Experimentally, active vitamin D inhibits atherogenic cellular behaviors and activation of the renin-angiotensin system. Thus, active vitamin D is a regulator of cardiovascular and kidney functions.
Shoji
Tetsuo
T
Osaka City University Graduate School of Medicine, Depanartment of Metabolism, Endocrinology and Molecular Medicine.
Nishizawa
Yoshiki
Y
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000517:prevention & control; D006801:Humans; D007154:Immune System Diseases / Q000517:prevention & control; D007249:Inflammation / Q000517:prevention & control; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D011507:Proteinuria / Q000517:prevention & control; D018167:Receptors, Calcitriol / Q000502:physiology; D006435:Renal Dialysis / Q000009:adverse effects; D012084:Renin-Angiotensin System / Q000502:physiology; D012306:Risk; D014807:Vitamin D / Q000494:pharmacology* / Q000502:physiology*
D018167:Receptors, Calcitriol; D014807:Vitamin D