title: Testing equivalence between two laboratories or two methods using paired-sample analysis and interval hypothesis testing.
abstract: A modified interval hypothesis testing procedure based on paired-sample analysis is described, as well as its application in testing equivalence between two bioanalytical laboratories or two methods. This testing procedure has the advantage of reducing the risk of wrongly concluding equivalence when in fact two laboratories or two methods are not equivalent. The advantage of using paired-sample analysis is that the test is less confounded by the intersample variability than unpaired-sample analysis when incurred biological samples with a wide range of concentrations are included in the experiments. Practical aspects including experimental design, sample size calculation and power estimation are also discussed through examples.
authors.affiliation: Philip Morris USA, Research Center, 4201 Commerce Road, Richmond, VA 23234, USA. shixia.feng@pmusa.com
authors.forename: Shixia
authors.initials: S
authors.lastname: Feng
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Liang
authors.forename: Robin D
authors.initials: RD
authors.lastname: Kinser
authors.forename: Kirk
authors.initials: K
authors.lastname: Newland
authors.forename: Rudolf
authors.initials: R
authors.lastname: Guilbaud
mesh_terms: D007753:Laboratories; D012107:Research Design