Copper(I)-Fesulphos Lewis Acid catalysts for enantioselective Mannich-type reaction of N-sulfonyl imines.
[reaction: see text] Copper(I) complexes of Fesulphos ligands are efficient chiral Lewis acid catalysts in the Mannich-type addition of silyl enol ethers of ketones, esters, and thioesters to N-(2-thienyl)sulfonyl aldimines. The corresponding optically active beta-amino carbonyl derivatives were obtained in good yields (58-91%) and with moderate to good enantioselectivity (61-93% ee). Removal of the N-activating group was achieved under mild conditions by simple treatment of the products with Mg in methanol.
Gonzalez
Alvaro Salvador
AS
Departamento de Química Organica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Spain.
Arrayas
Ramón Gómez
RG
Carretero
Juan C
JC