title: Design variables for mechanical properties of bone tissue scaffolds.
abstract: The reconstruction of segmental defect in long bone is a clinical challenge. Multiple surgeries are typically required to restore the structure and function of the affected defect site. In order to overcome this defect a biodegradable bone tissue engineering scaffold is used. This scaffold acts as a carrier of proteins and growth factors, while also supporting the load that the bone would normally sustain, until the natural bone can regenerate in its place. Work was done to optimize an existing solid free-form scaffold design. The goal of the optimization was to increase the porosity of the scaffold while maintaining the strength of a previously-tested prototype design. With this in mind, eight new designs were created. These designs were drawn using CAD software and then through the use of finite element analysis the theoretical ultimate compressive strength of each design was obtained. Each scaffold design was constructed by casting a thermal-curable poly(propylene fumarate)/tricalcium phosphate (PPF/TCP) suspension into wax molds fabricated on inkjet printing rapid prototyping machine. The constructs were then experimentally tested by applying a uniaxial compressive load. The theoretical and experimental values of ultimate compressive strength and specific strength of each design were compared. Theoretically, the best scaffold design produced from this work improved upon the current design by increasing the porosity by 46% and also increasing the ultimate compressive strength by 27%. The experimental data was found to match the theoretical strength in four designs, but deviate from the theoretical strength in five designs. The reasons for the deviations and their relation to the rapid prototyping manufacturing technique were discussed. The results of this work show that it is possible to increase the porosity and strength of a bone tissue engineering scaffold through simple iterations in architectural design.
authors.affiliation: Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, 1120 South Drive, Rm. 146, Indianapolis, IN 46202, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Howk
authors.forename: Tien-Min G
authors.initials: TM
authors.lastname: Chu
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D001696:Biomechanical Phenomena / Q000379:methods; D018786:Bone Substitutes / Q000032:analysis / Q000737:chemistry*; D017076:Computer-Aided Design; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008422:Materials Testing; D016062:Porosity; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes