Hantavirus cardiopulmonary syndrome: immune response and pathogenesis.
Hantaviruses are emerging viruses in the Americas that cause cardiopulmonary syndrome with high lethality. The intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. On the other hand, the humoral immune response seems to be essential for recovery from infection.
Borges
Alessandra A
AA
Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo 14049-900, Brazil.
Campos
Gelse M
GM
Moreli
Marcos L
ML
Souza
Ricardo L M
RL
Aquino
Victor H
VH
Saggioro
Fabiano P
FP
Figueiredo
Luiz T M
LT
D000914:Antibodies, Viral / Q000032:analysis; D006476:Orthohantavirus / Q000235:genetics / Q000276:immunology; D018804:Hantavirus Pulmonary Syndrome / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological; D014766:Viremia
D000914:Antibodies, Viral