In vitro studies on gemcitabine combinations with other antiblastics.
The use of gemcitabine in combination with chemotherapeutic agents, including cisplatin, pemetrexed and taxanes, is characterized by the enhancement of their anticancer activity. The analysis of the underlying pharmacodynamics has revealed that modulation of nucleotide pools, drug metabolism, and cellular DNA repair capability are the most common factors to explain the additive to synergistic interaction between gemcitabine and anticancer agents in several human cancers in vitro and in vivo.
Giovannetti
E
E
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Italy.
Danesi
R
R
Mey
V
V
Nannizzi
S
S
Pasqualetti
G
G
Del Tacca
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D011355:Prodrugs / Q000008:administration & dosage; D014407:Tumor Cells, Cultured; D000093542:Gemcitabine
D011355:Prodrugs; D003841:Deoxycytidine; D000093542:Gemcitabine