title: [Ph+ acute lymphoblastic leukemia combined with lung and brain invasive aspergillosis].
abstract: This study was aimed to investigate the clinical features and therapy of Ph(+) acute lymphoblastic leukemia (Ph(+)ALL) combined with invasive aspergillosis. A series of examination, including routine blood and bone marrow picture analysis, chest roentgenography, cranial computerized tomography and detection of cell genetics etc were carried out for a Ph(+)ALL patient combined with invasive aspergillosis. This patient received chemotherapy with DVCP, idarubicin and imatinib mesylate and was treated with sporanox and amphotericin B (Amb; including Amb-L) and cerebrotomy for drainage because the invasive aspergillosis occurred during myelosuppression. The results showed that patient gained complete remission and the invasive aspergillosis was controlled successfully. It is concluded that patient with Ph(+)ALL has poor prognosis despite intensive conventional chemotherapy, imatinib mesylate may prove to be an effective treatment for Ph(+)ALL. Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis.
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China. huangmei@medmail.com.cn
authors.forename: Mei
authors.initials: M
authors.lastname: Huang
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Zhou
authors.forename: Dan
authors.initials: D
authors.lastname: Ran
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Zhang
authors.forename: Han-Ying
authors.initials: HY
authors.lastname: Sun
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Liu
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D001549:Benzamides; D001927:Brain Diseases / Q000150:complications / Q000382:microbiology*; D006801:Humans; D000068877:Imatinib Mesylate; D017964:Itraconazole / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000209:etiology; D010879:Piperazines / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000382:microbiology; D011743:Pyrimidines / Q000008:administration & dosage
chemical_list: D000935:Antifungal Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D017964:Itraconazole; D000068877:Imatinib Mesylate