Comparative genetic mutation frequencies based on amino acid composition differences.
Genetic variation inferred from large-scale amino acid composition comparisons among genomes and chromosomes of several species, Saccharomyces cerevisiae, Drosophila melanogaster, Ceanorhabditis elegans, H. sapiens, is shown to be correlated (highest, r(2)=0.9855, p<0.01) with reported mutation rates for various genes in these species. This study, based largely on pseudogene data, helps to establish reference mutation frequencies that are likely to be representative of overall genome mutation rates in each of the species examined, and provides further insight into heterogeneity of mutation rates among genomes.
Vieira
Amandio
A
Endocrine & Metabolic Research Laboratory, K9600, Faculty of Applied Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada. avvieira@sfu.ca <avvieira@sfu.ca>
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics; D006801:Humans; D009154:Mutation; D011544:Pseudogenes; D012441:Saccharomyces cerevisiae / Q000235:genetics
D000596:Amino Acids