title: Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.
abstract: OBJECTIVE
  The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease.
  
  
  METHODS
  Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy.
  
  
  RESULTS
  Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI).
  
  
  CONCLUSIONS
  Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.
authors.affiliation: Nuclear Medicine Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9061, USA. Frederick.Bonte@UTSouthwestern.edu
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Bonte
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Harris
authors.forename: Linda S
authors.initials: LS
authors.lastname: Hynan
authors.forename: Eileen H
authors.initials: EH
authors.lastname: Bigio
authors.forename: Charles L
authors.initials: CL
authors.lastname: White
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003704:Dementia / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime