Antiinflammatory activity of Polygala japonica extract.
The antiinflammatory activity of the aqueous extract of Polygala japonica (AEPJ) was investigated in mice and rats to find the pharmacological basis for its ethnomedical use. The extract produced a significant inhibition of peritoneal and cutaneous vascular permeability induced by acetic acid and histamine, respectively and ear swelling induced by picryl chloride in mice at the dose of 25.0 mg/kg. Moreover, the extract markedly inhibited footpad edema induced by histamine in rats, and decreased prostaglandin E(2) (PGE(2)) content in carrageenan-induced air-pouch at doses of 12.5 and 6.25 mg/kg respectively.
Kou
Junping
J
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, P.R. China. junpingkou@163.com
Si
Minda
M
Dai
Guofei
G
Lin
Yuwen
Y
Zhu
Danni
D
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006632:Histamine; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010853:Picryl Chloride; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D031801:Polygala; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D006632:Histamine; D002351:Carrageenan; D010853:Picryl Chloride