3-Methyl-4-chlorophenol for prion decontamination of medical devices.
Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrP(Sc) sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.
Riemer
Constanze
C
Robert-Koch-Institut, Nordufer, Germany.
Bamme
Theresa
T
Mok
Simon Wing Fai
SW
Baier
Michael
M
D015153:Blotting, Western; D002733:Chlorophenols; D004202:Disinfectants; D004864:Equipment and Supplies; D011328:Prions
C515248:3-methyl-4-chlorophenol; D002733:Chlorophenols; D004202:Disinfectants; D011328:Prions