ent-Trachylobane diterpenoids from Xylopia langsdorffiana.
Two new diterpenes of the ent-trachylobane type were isolated from the stems of Xylopia langsdorffiana, ent-7alpha-acetoxytrachyloban-18-oic acid (1) and ent-7alpha-hydroxytrachyloban-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. X-ray crystallography of 1 was used to confirm its structure. The cytotoxic activity of 1 against V79 fibroblasts and rat hepatocytes was investigated.
Tavares
Josean Fechine
JF
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970, João Pessoa, Paraíba, Brazil.
Queiroga
Karine F
KF
Silva
Marianna Vieira B
MV
Diniz
Margareth F F M
MF
Filho
José M B
JM
da-Cunha
Emidio V L
EV
de Simone
Carlos Alberto
CA
Júnior
João X de Araújo
JX
Melo
Patrícia S
PS
Haun
Marcela
M
da Silva
Marcelo Sobral
MS
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D001938:Brazil; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D004224:Diterpenes