Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin A.
OBJECTIVE
To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).


METHODS
Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.


RESULTS
The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6%, P < 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P < 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P < 0.01), and showed significant difference from those in the control group (P < 0.05).


CONCLUSIONS
Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.
Zhang
Xue-zhong
XZ
Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China. xuezhong1968@sina.com
Xu
Yan-li
YL
Jin
Juan
J
Zhang
Xiu-qun
XQ
Zhang
Lei
L
Su
Ai-ling
AL
D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy*; D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D015672:Erythroid Precursor Cells; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D010976:Platelet Count; D012156:Reticulocytes / Q000166:cytology; D013197:Stanozolol / Q000627:therapeutic use; D013607:Tablets
D000728:Androgens; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D013607:Tablets; C516453:shengxuening; D013197:Stanozolol; D016572:Cyclosporine