Serotypes of Streptococcus pneumoniae isolated from blood and cerebrospinal fluid related to vaccine serotypes and to clinical characteristics.
Pneumococci isolated from blood and cerebrospinal fluid from 1998 to 2001 in 2 counties in south-west Sweden were serotyped with the capsular reaction test. Of the 836 strains, 353 (42%), 598 (72%) and 789 (94%) belonged to serotypes included in the 7- and 11-valent pneumococcal conjugate vaccines and in the 23-valent polysaccharide vaccine, respectively. The most common serotype was type 1 (119 isolates) followed in descending frequency by serotypes 7F, 9V, 14, 4 and 12F (90-49 isolates per serotype). The coverage rates of the 7- and 11-valent conjugate vaccines among 58 strains isolated from children and adolescents 0-19 y of age were 46% and 93%, respectively. A comparison of clinical characteristics of infections caused by different serotypes showed that types 1 and 7F were less commonly associated with severe underlying diseases, that patients infected with these serotypes were younger than the average and, thus, had a lower case-fatality rate.
Berg
Stefan
S
Queen Silvia Children's Hospital, Göteborg, Sweden. Stefan.berg@pediat.gu.se
Trollfors
Birger
B
Persson
Elisabet
E
Backhaus
Erik
E
Larsson
Peter
P
Ek
Elisabeth
E
Claesson
Berndt E
BE
Jonsson
Lars
L
Rådberg
Gunilla
G
Johansson
Siv
S
Ripa
Torvald
T
Kaltoft
Margit S
MS
Konradsen
Helle Bossen
HB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D011008:Pneumococcal Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000382:microbiology*; D012703:Serotyping; D022541:Streptococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology
D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate