[Selective apheresis of low-density lipoproteins].
The case of rare complicated homozygous hypercholesterolemia treated by a direct adsorption of lipoprotein apheresis procedure is presented in this article. In total eight sessions of direct adsorption of lipoprotein apheresis were performed on 14-year-old patient from June 2004 to January 2005. Blood flow rate was 30-50 ml/min. Central or ulnar veins were punctured. Lipids levels before and after lipid apheresis were measured during each session throughout the study period. The mean decrease in low-density lipoprotein cholesterol levels was 34.3-52.6% compared to baseline, total cholesterol--26.4-49.1%, lipoprotein (a)--67.4 and 90.9%, apolipoprotein B--26.4 and 48.4%. No side effects and complications were observed. The last four sessions were performed in a day unit.
Griskevicius
Antanas
A
Department of Therapeutic Apheresis, Vilnius University Hospital, Clinics of Santariskes, Santariskiu 2, 08661 Vilnius, Lithuania. Antanas.Griskevicius@santa.lt
Audzijoniene
Judita
J
D000293:Adolescent; D001055:Apolipoproteins B / Q000097:blood; D001781:Blood Component Removal; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000235:genetics / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D011677:Punctures; D013997:Time Factors; D016896:Treatment Outcome
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D002784:Cholesterol