Characterization of a novel porin involved in systemic Yersinia enterocolitica infection.
Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a DeltasfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin.
Mildiner-Earley
Shirly
S
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Miller
Virginia L
VL
D000208:Acute Disease; D000818:Animals; D015169:Colony Count, Microbial; D008198:Lymph Nodes / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008643:Mesentery; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009154:Mutation; D018272:Porins / Q000737:chemistry / Q000502:physiology*; D014774:Virulence; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D015008:Yersinia enterocolitica / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*
D018272:Porins; C512602:SfpA protein, Yersinia enterocolitica