Stem cells for the treatment of neurological disorders.
Many common neurological disorders, such as Parkinson's disease, stroke and multiple sclerosis, are caused by a loss of neurons and glial cells. In recent years, neurons and glia have been generated successfully from stem cells in culture, fueling efforts to develop stem-cell-based transplantation therapies for human patients. More recently, efforts have been extended to stimulating the formation and preventing the death of neurons and glial cells produced by endogenous stem cells within the adult central nervous system. The next step is to translate these exciting advances from the laboratory into clinically useful therapies.
Lindvall
Olle
O
Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden. olle.lindvall@med.lu.se
Kokaia
Zaal
Z
D064987:Cell- and Tissue-Based Therapy / Q000639:trends; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D044968:Regenerative Medicine / Q000639:trends; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*