Gene amplification: yeast takes a turn.
The origins of gene amplifications in mammalian cells have been difficult to analyze because of secondary genome rearrangements. Recent studies in budding yeast, including in this issue of Cell, have provided new insights into the role of palindromic sequences in gene amplification.
Haber
James E
JE
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. haber@brandeis.edu
Debatisse
Michelle
M
D000818:Animals; D005784:Gene Amplification; D020440:Gene Duplication; D008322:Mammals / Q000235:genetics; D008957:Models, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014178:Translocation, Genetic