title: A novel peptide that selectively binds highly metastatic hepatocellular carcinoma cell surface is related to invasion and metastasis.
abstract: Using a phage display approach, we identified AWYPLPP peptide as a specific peptide ligand that binds to the cell surface of highly metastatic human hepatocellular carcinoma (HCC). Moreover, the peptide was able to promote in vitro invasion of highly metastatic HCC cells by activating matrix metalloproteinase-9 and in vivo lung metastasis of HCC tumors. These results indicate that AWYPLPP peptide likely recognizes a novel receptor that is selectively expressed on the cell surface of highly metastatic HCC and mediates cellular activities associated with the invasive phenotype. Identification of the receptor for the AWYPLPP peptide may provide new insights into the molecular mechanism of HCC metastasis.
authors.affiliation: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Jia
authors.forename: Hui-Chuan
authors.initials: HC
authors.lastname: Sun
authors.forename: Ju-Bo
authors.initials: JB
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Qian
authors.forename: Jin-Zhong
authors.initials: JZ
authors.lastname: Pang
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Lun-Xiu
authors.initials: LX
authors.lastname: Qin
authors.forename: Yin-Kun
authors.initials: YK
authors.lastname: Liu
authors.forename: Zhao-You
authors.initials: ZY
authors.lastname: Tang
mesh_terms: D000595:Amino Acid Sequence; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009842:Oligopeptides / Q000378:metabolism*
chemical_list: D009842:Oligopeptides