Chemical biology and bacteria: not simply a matter of life or death.
Chemical biological approaches to understanding bacteria have largely been confined to screening for antibiotics. More complex phenotypes, such as virulence, have largely been studied using bacterial genetics. However, it has recently become clear that these two methods are complementary and that combining chemical biologic and genetic approaches to studying bacteria brings new power to old problems.
Hung
Deborah T
DT
Department of Microbiology and Molecular Genetics, Harvard Medical School, USA; Division of Infectious Disease, Brigham and Women's Hospital, USA.
Rubin
Eric J
EJ
D001419:Bacteria / Q000737:chemistry* / Q000235:genetics*; D015195:Drug Design; D016680:Genome, Bacterial; D008967:Molecular Biology / Q000379:methods*