Heat-shock protein 70 genes and human longevity: a view from Denmark.
We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age-dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.
Singh
Ripudaman
R
Department of Human Genetics, Bartholin Building, University of Aarhus, Denmark. singh@humgen.au.dk
Kølvraa
Steen
S
Bross
Peter
P
Christensen
Kaare
K
Gregersen
Niels
N
Tan
Qihua
Q
Jensen
Uffe Birk
UB
Eiberg
Hans
H
Rattan
Suresh I S
SI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002896:Chromosomes, Human, Pair 6; D015331:Cohort Studies; D003718:Denmark; D005260:Female; D005787:Gene Frequency; D018840:HSP70 Heat-Shock Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D006239:Haplotypes; D018869:Heat-Shock Response / Q000235:genetics / Q000502:physiology*; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D008297:Male; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide; D016019:Survival Analysis; D014427:Twins / Q000235:genetics*
D018840:HSP70 Heat-Shock Proteins