title: [The effects of probiotics on symptoms of irritable bowel syndrome].
abstract: OBJECTIVE
  Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) tract disorder that has heterogeneous clinical presentations such as abdominal pain, diarrhea, constipation, and abdominal distension. It is known that several mechanisms are involved in the pathogenesis of IBS. Probiotics may target one or more pathophysiologic pathways in IBS and may improve the symptoms of IBS. However, the results of studies about probiotics on IBS are controversial. Therefore, the aim of this study was to evaluate the effect of probiotics on GI symptoms and intestinal gas volume changes in patients with IBS.
  
  
  METHODS
  Forty patients were randomly allocated to be treated with Medilac DS (Bacillus subtilis, Streptococcus faecium) (n=20) or placebo (n=20) in a double-blind, prospective manner. The change in intestinal gas volume and symptom scores after 4-week treatment were evaluated for the efficacy.
  
  
  RESULTS
  There was no significant difference in bloating, frequency of gas expulsion, frequency of defecation, and hardness of stool before and after the treatment. However, the severity of abdominal pain and the frequency of abdominal pain decreased significantly in Medilac DS group (2.4+/-1.3 cm/day --> 1.6+/-1.6 cm/day, 1.7+/-1.3/day --> 1.0+/-1.0/day) (p=0.044, p=0.038), but not in placebo group (2.1+/-2.0 cm/day --> 1.8+/-2.1 cm/day, 1.3+/-1.2/day --> 1.4+/-1.9/day). In both groups, intestinal gas volume at baseline, after 2-week treatment, and after 4-week treatment did not show significant change. Medilac DS was well tolerated without adverse events.
  
  
  CONCLUSIONS
  Medilac DS is a safe and useful probiotic agent for the treatment of abdominal pain in patients with IBS.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young Gyun
authors.initials: YG
authors.lastname: Kim
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Moon
authors.forename: Kuen Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Nu Ri
authors.initials: NR
authors.lastname: Chon
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000628:therapy; D000328:Adult; D001412:Bacillus subtilis; D004311:Double-Blind Method; D016984:Enterococcus faecium; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000627:therapeutic use*