title: Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy.
abstract: A 20-month-old German shepherd with primary pancreatic acinar atrophy and exocrine pancreatic insufficiency that was treated with pancreatic enzyme supplementation, vitamin B12, and cimetidine developed oral bleeding. Following discontinuation of the cimetidine, increased preincubation of the enzymes with the food, and symptomatic therapy for the ulceration, the dog's condition improved.
authors.affiliation: Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4. liz.snead@usask.ca
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Snead
mesh_terms: D000818:Animals; D001284:Atrophy / Q000662:veterinary; D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D010188:Exocrine Pancreatic Insufficiency / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D006472:Oral Hemorrhage / Q000139:chemically induced / Q000662:veterinary*; D019226:Oral Ulcer / Q000139:chemically induced / Q000662:veterinary*; D010179:Pancreas / Q000201:enzymology; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D004791:Enzyme Inhibitors; D002927:Cimetidine; D014805:Vitamin B 12