Synthesis and biological activity of amide derivatives of nimbolide.
Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.
Sastry
B S
BS
Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad.
Suresh Babu
K
K
Hari Babu
T
T
Chandrasekhar
S
S
Srinivas
P V
PV
Saxena
A K
AK
Madhusudana Rao
J
J
D000577:Amides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D031601:Azadirachta / Q000378:metabolism; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry*; D008956:Models, Chemical; D010936:Plant Extracts / Q000378:metabolism; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000378:metabolism
D000577:Amides; D000970:Antineoplastic Agents; D036701:Limonins; D010936:Plant Extracts; C042198:nimbolide