title: Delivering drugs to the central nervous system: a medicinal chemistry or a pharmaceutical technology issue?
abstract: This review aims to summarize the non-invasive approaches employed in delivering drugs to the central nervous system which is severely hindered by the presence of the blood-brain barrier (BBB) that limits molecular permeation. Particular attention will be placed on the several available strategies for delivering drugs into the brain, through circumvention of the BBB, in order to critically address the medicinal chemistry and the pharmaceutical technology contributions.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1, 06123, Perugia Italy. riky@unipg.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ricci
authors.forename: Paolo
authors.initials: P
authors.lastname: Blasi
authors.forename: Stefano
authors.initials: S
authors.lastname: Giovagnoli
authors.forename: Carlo
authors.initials: C
authors.lastname: Rossi
mesh_terms: D001812:Blood-Brain Barrier; D002490:Central Nervous System; D016503:Drug Delivery Systems; D006801:Humans; D010316:Particle Size; D011355:Prodrugs
chemical_list: D011355:Prodrugs