title: Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population.
abstract: OBJECTIVE
  To assess the association between the single nucleotide polymorphism of the insulin receptor (INSR) gene and polycystic ovary syndrome (PCOS) in a Korean population.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  One hundred seventy-four patients with PCOS and 93 healthy women as controls.
  
  
  METHODS
  Frequency of three genotypes for single nucleotide polymorphism found in exon 17 of INSR gene.
  
  
  RESULTS
  The high frequency of the T allele was shown both in patient and control groups. The frequency of C allele, which known as a normal allele, was slightly higher in the patient group than in the control group.
  
  
  CONCLUSIONS
  The C/T polymorphism in exon 17 of the INSR gene is not associated with susceptibility of PCOS in a Korean population.
authors.affiliation: Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Fertility Medical Center, Pochon CHA University, CHA General Hospital, Kangnam-Gu, Seoul 135-081, Korea.
authors.forename: Eung-Ji
authors.initials: EJ
authors.lastname: Lee
authors.forename: Kyong-Jai
authors.initials: KJ
authors.lastname: Yoo
authors.forename: So-Jeong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sook-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Kwang Yul
authors.initials: KY
authors.lastname: Cha
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003596:Cytosine; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011972:Receptor, Insulin / Q000235:genetics*; D013941:Thymine
chemical_list: D003596:Cytosine; D011972:Receptor, Insulin; D013941:Thymine