Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.
Linarin (acacetin-7-O-beta-d-rutinoside) from the flower extract of Mentha arvensis showed selective dose dependent inhibitory effect on acetylcholinesterase.
Oinonen
Päivi P
PP
Drug Discovery and Development Technology Center, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland. pmpti005@chiangmai.ac.th
Jokela
Jouni K
JK
Hatakka
Annele I
AI
Vuorela
Pia M
PM
D000110:Acetylcholinesterase / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D027541:Mentha; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D002800:Cholinesterase Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D000110:Acetylcholinesterase; C008282:linarin