[Development of an anti-infection nano-hydroxypatite drug delivery microsphere and its drug-release in vitro].
OBJECTIVE
To develop an anti-infection nano-hydroxypatite (nano-HA) microsphere for local drug delivery for treating osteomyelitis.


METHODS
The nano-HA was used as the core carrier to load gentamicin (GM) and coated with poly(-hydroxybutyrate-co- hydroxyvalerate)/polyethylene glycol (PHBV/PEG), which was degradable and biocompatible, to prepare nano-HA-PHBV/PEG-GM microsphere. The surface structure and in vitro drug-release of the microsphere were studied.


RESULTS
The microsphere had good drug delivery capability. The samples weighing 90 mg each were soaked in PBS and gentamicin release within the first day was 165.2 microg/ml, which maintained a low release rate in the following days. After 28 days, gentamicin release declined to 8.5 microg/ml, which was higher than the minimal inhibitory concentration of gentamicin (2 microg/ml).


CONCLUSIONS
The local drug delivery system has good drug-release performance in vitro and may possess potential value in clinical management of osteomyelitis.
Wang
Yong-feng
YF
Department of Othopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. wyfwf2@163.com
Jin
An-min
AM
Wei
Kun
K
Wang
Xu-dong
XD
Tang
Shan-hua
SH
Min
Shao-xiong
SX
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D005839:Gentamicins / Q000737:chemistry / Q000493:pharmacokinetics*; D006882:Hydroxyapatites / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry; D000094122:Polyhydroxybutyrates
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005839:Gentamicins; D006882:Hydroxyapatites; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates