title: APPLied mechanics: uncovering how adiponectin modulates insulin action.
abstract: Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hosch
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Olefsky
authors.forename: Jane J
authors.initials: JJ
authors.lastname: Kim
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: C464801:APPL1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D052242:Adiponectin; C510733:Appl1 protein, mouse; D002352:Carrier Proteins; D007328:Insulin; D011956:Receptors, Cell Surface