A mathematical model of integrin-mediated haptotactic cell migration.
Haptotactic cell migration, a directed response to gradients of cell-extracellular matrix adhesion, is an important process in a number of biological phenomena such as wound healing and tumour cell invasion. Previously, mathematical models of haptotaxis have been developed on the premise that cells migrate in response to gradients in the density of the extracellular matrix. In this paper, we develop a novel mathematical model of haptotaxis which includes the adhesion receptors known as integrins and a description of their functional activation, local recruitment and protrusion as part of lamellipodia. Through the inclusion of integrins, the modelled cell matter is able to respond to a true gradient of cell-matrix adhesion, represented by functionally active integrins. We also show that previous matrix-mediated models are in fact a subset of the novel integrin-mediated models, characterised by specific choices of diffusion and haptotaxis coefficients in their model equations. Numerical solutions suggest the existence of travelling waves of cell migration that are confirmed via a phase plane analysis of a simplified model.
Mallet
D G
DG
School of Mathematical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia. dg.mallet@qut.edu.au
Pettet
G J
GJ
D000465:Algorithms; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D003198:Computer Simulation; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000378:metabolism
D016023:Integrins; D010447:Peptide Hydrolases