Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury.
Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. The absolute numbers of circulating mesenchymal stem cells (cMSCs) in two different models of acute and chronic skeletal muscle injury were determined. cMSCs were present in significantly higher numbers in both models than in healthy controls. These results support the hypothesis that MSCs are mobilised into the bloodstream after skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of MSCs into the circulation.
Ramírez
M
M
Servicio de Oncohematología y Transplante, Hospital Universitario Niño Jesús, Avda Menéndez Pelayo 65, 28009 Madrid, Spain.
Lucia
A
A
Gómez-Gallego
F
F
Esteve-Lanao
J
J
Pérez-Martínez
A
A
Foster
C
C
Andreu
A L
AL
Martin
M A
MA
Madero
L
L
Arenas
J
J
García-Castro
J
J
D000328:Adult; D001265:Athletic Injuries / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006012:Glycogen Storage Disease Type V / Q000378:metabolism; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000293:injuries* / Q000378:metabolism; D012420:Running / Q000502:physiology*
D003402:Creatine Kinase