title: Isolation and identification of 5-methyl-imidazolin-4-one derivative as glyceraldehyde-derived advanced glycation end product.
abstract: We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and N(alpha)-acetylarginine. A major product was identified as N(alpha)-acetyl-N(delta)-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.
authors.affiliation: Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Kawasaki, Kanagawa.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Usui
authors.forename: Hirohito
authors.initials: H
authors.lastname: Watanabe
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Hayase
mesh_terms: D002851:Chromatography, High Pressure Liquid; D017127:Glycation End Products, Advanced / Q000737:chemistry* / Q000302:isolation & purification*; D005985:Glyceraldehyde / Q000737:chemistry*; D048288:Imidazolines / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: C512937:5-methyl-imidazolin-4-one; D017127:Glycation End Products, Advanced; D048288:Imidazolines; D005985:Glyceraldehyde