Pediatric asthmatic patients have low serum levels of monocyte chemoattractant protein-1.
Serum levels of MCP-1 were measured in children with and without asthma in order to determine a possible correlation between the MCP-1-2518A/G polymorphism, serum levels of MCP-1 and asthma. Two groups of subjects -160 children with asthma and 158 healthy children were screened with a PCR-based genotyping assay. Serum MCP-1 level was measured by ELISA. The -2518G allele occurred at a significantly higher frequency in asthmatic children than in controls. The mean serum MCP-1 level was significantly lower in the asthmatic than in the control children. There was no significant association between the MCP-1 genotypes and the serum MCP-1 levels.
Keszei
Márton
M
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Nagy
Adrienne
A
Kozma
Gergely T
GT
Radosits
Károly
K
Tölgyesi
Gergely
G
Falus
András
A
Szalai
Csaba
C
D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000150:complications; D018932:Chemokine CCL2 / Q000097:blood* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D023521:Chlamydophila Infections / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
D018932:Chemokine CCL2; D005938:Glucocorticoids