Molluscicidal activity against Bulinus truncatus of Croton campestris.
The bark of Croton campestris provided three furano-clerodane named, respectively, velamone, velamolone acetate and velamolone. Fractions containing these diterpenoids were investigated for their molluscicidal activity against Bulinus truncatus, one of the aquatic snail vectors of schistosomiasis. A dichloromethanic extract of root barks, rich in furano-clerodane and molluscicidal at 20ppm was promising as natural molluscicide. Enriched fraction with velamone gave 80% mortality from 25ppm, while its LD(100) was at 50ppm. The LD(80) was ca. at 45ppm, while LD(100) was at 60ppm for the enriched fraction containing velamolone acetate. The velamolone-enriched fraction was less efficient and gave a mortality of 90% at 90ppm. The pure compounds, velamone and velamolone acetate were active at 100% at 3 and 6ppm, respectively. Velamolone showed a molluscicidal activity at 20ppm.
El Babili
F
F
Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152-IRD-Université Paul Sabatier (Toulouse III)-Faculté des Sciences Pharmaceutiques, 35 ch. des maraîchers-F-31062 Toulouse cedex 09, France. demnate@club-internet.fr
Fabre
N
N
Moulis
C
C
Fouraste
I
I
D000818:Animals; D002033:Bulinus / Q000187:drug effects*; D029802:Croton / Q000737:chemistry*; D008975:Molluscacides / Q000032:analysis*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D008975:Molluscacides; D010936:Plant Extracts