Do longevity mutants always show trade-offs?
A number of genetic mutations that substantially increase longevity have been discovered in model organisms. Although these long-lived mutants have provided many insights into the factors that affect longevity, the results from such studies should be interpreted with caution. In particular, at least some of these mutations may be poor guides to human medical intervention because they often have deleterious side effects on important biological functions.
Van Voorhies
Wayne A
WA
Molecular Biology Program, MSC 3MLS, New Mexico State University, Las Cruces, NM 88003, USA. wvanvoor@nmsu.edu
Curtsinger
James W
JW
Rose
Michael R
MR
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D009154:Mutation / Q000235:genetics / Q000502:physiology; D012098:Reproduction / Q000502:physiology