Interleukin-6 has no effect on surfactant or lung function in different lung insults.
The current study determined if interleukin-6 (IL-6) had a causative role in the lung dysfunction and/or surfactant alterations associated with three different lung insults. IL-6 (or saline) was instilled into rats followed by mechanical ventilation in vivo for 4 hours. Also, IL-6 (-/-) and wild-type mice were subjected to 3 insults: ex vivo injurious mechanical ventilation; cecal ligation and perforation; and hyperoxia exposure. In all experiments, the presence or absence of IL-6 did not significantly influence gas exchange, lung compliance, or various surfactant measurements. These results suggest that IL-6 may have a limited role in the surfactant alterations observed in acute lung injury.
Nakamura
Tomoo
T
Department of Perinatal Medicine and Maternal Care, National Center for Children Health and Development, Tokyo, Japan.
Moyer
Brent Z
BZ
Veldhuizen
Ruud A W
RA
Lewis
James F
JF
D000818:Animals; D018893:Bronchoalveolar Lavage / Q000009:adverse effects; D002432:Cecum / Q000293:injuries; D004195:Disease Models, Animal; D018496:Hyperoxia / Q000150:complications; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012121:Respiration, Artificial / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000276:immunology*; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology
D015850:Interleukin-6; D011663:Pulmonary Surfactants