title: Potent 4-amino-5-azaindole factor VIIa inhibitors.
abstract: The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.
authors.affiliation: Celera Genomics, South San Francisco, CA 94080, USA. huiyong.hu@yahoo.com
authors.forename: Huiyong
authors.initials: H
authors.lastname: Hu
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Kolesnikov
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Riggs
authors.forename: Kieron E
authors.initials: KE
authors.lastname: Wesson
authors.forename: Robin
authors.initials: R
authors.lastname: Stephens
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Leahy
authors.forename: William D
authors.initials: WD
authors.lastname: Shrader
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sprengeler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Green
authors.forename: Ellen
authors.initials: E
authors.lastname: Sanford
authors.forename: Margaret
authors.initials: M
authors.lastname: Nguyen
authors.forename: Erik
authors.initials: E
authors.lastname: Gjerstad
authors.forename: Ronnel
authors.initials: R
authors.lastname: Cabuslay
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Young
mesh_terms: D015942:Factor VIIa / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D011725:Pyridines; D015942:Factor VIIa