Macrophage dynamics in diabetic wound dealing.
Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance.
Waugh
Helen V
HV
School of Mathematics and Computing, Heriot-Watt University, Riccarton, Edinburgh, EH14 4AS, UK. hwaugh@ma.hw.ac.uk
Sherratt
Jonathan A
JA
D000465:Algorithms; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D008954:Models, Biological; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D016212:Transforming Growth Factor beta