title: Effects of celiprolol and simvastatin on the calculated risk of coronary heart disease (the Celisimva study).
abstract: OBJECTIVE
  The most important risk factors for coronary heart disease are hypercholesterolemia, smoking and hypertension. To find out which treatment is more effective in modifying the total risk--lowering cholesterol concentration or using antihypertensive treatment--we conducted a parallel group placebo-controlled study. The goal of the study was to assess the effect of two drugs on the calculated CHD Framingham risk score in subjects with both moderate hypertension and moderate hypercholesterolemia.
  
  
  METHODS
  Celiprolol for hypertension and simvastatin for cholesterol-lowering were given as monotherapy or as combination treatment. The effects of the treatments on the CHD risk scores were calculated after 3 months. A total of 112 patients were randomized.
  
  
  RESULTS
  The total CHD risk decreased in simvastatin and combination groups from 26% to 19% and from 26% to 17%, respectively. Celiprolol alone decreased the risk from 25% to 21%, which was not statistically different from placebo.
  
  
  CONCLUSIONS
  It can be concluded that subjects with moderate hypercholesterolemia and hypertension benefit more from lipid-lowering treatment with simvastatin than from blood pressure-lowering with beta blocker celiprolol.
authors.affiliation: Stockmannintie 8 B, 02700, Kauniainen, Finland. jyrki.olkinuora@fimnet.fi
authors.forename: Jyrki T
authors.initials: JT
authors.lastname: Olkinuora
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Hannu
authors.initials: H
authors.lastname: Vanhanen
authors.forename: Niina
authors.initials: N
authors.lastname: Makkonen
authors.forename: Tero
authors.initials: T
authors.lastname: Kalliomäki
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D017272:Celiprolol / Q000627:therapeutic use*; D003327:Coronary Disease / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D019821:Simvastatin; D017272:Celiprolol