The role of viral and cellular proteins in the budding of human immunodeficiency virus.
For over two decades, research on Human immunodeficiency virus (HIV), which is responsible for AIDS, has aimed at understanding of the molecular mechanisms used by this virus during its life cycle. An essential step in the HIV life cycle is the budding, which promotes the release of viral particles from the host cell. It has recently been revealed that HIV in the process of budding uses besides one viral protein also the machinery of the infected cell, in particular the proteins Tsg101 and ubiquitin. The viral protein is the p6 domain of the Gag precursor polyprotein. In normal cells, Tsg101 functions as a regulator of endocytic trafficking that recognizes ubiquitinated cargo and directs its delivery to degradative compartments. In HIV-infected cells, Tsg101 and ubiquitin interact with Gag p6 to promote the release of new viral particles from the host cell. Molecular mechanisms underlying the process of HIV budding from infected cells suggests a whole new range of drug targets that could prove useful in AIDS suppression in HIV-positive patients.
Mazzé
F M
FM
Grupo de Simulação Molecular, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil. femazze@usp.br
Degrève
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D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag / Q000502:physiology*; D006678:HIV / Q000502:physiology*; D006801:Humans; D014157:Transcription Factors / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; D014157:Transcription Factors; D025801:Ubiquitin; D000099177:Tsg101 Protein