title: Eicosapentapeptide repeats (EPRs): novel repeat proteins specific to flowering plants.
abstract: In this report, we describe a novel tandem peptide repeat protein, Eicosapentapeptide repeat (EPR), which occurs notably only in flowering plants. The EPRs are characterized by a 25 amino acid repeat unit, X(2)CX(4)CX(10)CX(2)HGGG, repeated 10 times tandemly. Sequence search revealed that the repeat motif is highly conserved across its occurrence. EPRs are predicted to exist as quasi-globular stable structures owing to highly conserved amino acid positions and potential disulfide bridges. Proteins containing EPRs are predicted to be located in chloroplasts; non-enzymatic and peptide or DNA-binding in molecular function; and they are possibly involved in transcription regulation.
authors.affiliation: Laboratory of Molecular Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Archak
authors.forename: Javaregowda
authors.initials: J
authors.lastname: Nagaraju
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence; D035264:Flowers / Q000378:metabolism*; D008969:Molecular Sequence Data; D012275:Oryza / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D013045:Species Specificity; D020080:Tandem Repeat Sequences
chemical_list: D010455:Peptides; D010940:Plant Proteins