Acute oxidative stress is associated with cell proliferation in the mouse liver.
Oxidative stress is known to produce tissue injury and to activate various signaling pathways. To investigate the molecular events linked to acute oxidative stress in mouse liver, we injected a toxic dose of paraquat. Liver necrosis was first observed, followed by histological marks of cell proliferation. Concomitantly, activation of the MAP kinase pathway and increased levels of the anti-apoptotic protein Bcl-XL were observed. Gene expression profiles revealed that the differentially expressed genes were potentially involved in cell proliferation. These data suggest that paraquat-induced acute oxidative stress triggers the activation of regeneration-related events in the liver.
Dragin
Nadine
N
EA 3674 - Laboratoire de Biologie de la Différenciation et du Développement, Université de Bordeaux 2, 146 Rue Léo-Saignat, 33076 Bordeaux Cedex, France.
Smani
Moneïm
M
Arnaud-Dabernat
Sandrine
S
Dubost
Clément
C
Moranvillier
Isabelle
I
Costet
Pierre
P
Daniel
Jean-Yves
JY
Peuchant
Evelyne
E
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001973:Bromodeoxyuridine; D049109:Cell Proliferation; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005796:Genes / Q000235:genetics; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009336:Necrosis; D020411:Oligonucleotide Array Sequence Analysis; D018384:Oxidative Stress; D010269:Paraquat / Q000494:pharmacology; D010766:Phosphorylation; D013997:Time Factors; D015854:Up-Regulation / Q000235:genetics; D051020:bcl-X Protein / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
D017362:Cyclic AMP Response Element-Binding Protein; D051020:bcl-X Protein; D004247:DNA; D000410:Alanine Transaminase; D048049:Extracellular Signal-Regulated MAP Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D001973:Bromodeoxyuridine; D010269:Paraquat