Synthesis of 2-substituted 3-aroylindenes via palladium-catalyzed carbonylative cyclization of diethyl 2-(2-(1-alkynyl)phenyl)malonates with aryl halides.
[reaction: see text] The palladium-catalyzed reaction of readily accessible diethyl 2-(2-(1-alkynyl)phenyl)malonates with aryl halides under a balloon pressure of CO produced 2-substitued 3-aroylindenes in good yields. The reaction is believed to proceed via cyclization of the alkyne containing a proximate nucleophilic center promoted by an acylpalladium complex.
Duan
Xin-Hua
XH
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, PR China.
Guo
Li-Na
LN
Bi
Hai-Peng
HP
Liu
Xue-Yuan
XY
Liang
Yong-Min
YM