title: Agglomeration tendency in dry pharmaceutical granular systems.
abstract: The agglomeration tendency of dry pharmaceutical mixtures containing various concentrations of Xylitab 100 (Xylitol), calcium carbonate precipitated (CCP) and magnesium stearate (MgSt) was evaluated statistically as a function of mixing time. A Ro-Tap tester was employed to mix the three pharmaceutical components, and the agglomerates formed were measured with respect to their weight and size. An experimental design was devised and applied to structure and then statistically analyze the results. Xylitab was found not to be influential in the formation of agglomerates, but aided in deagglomeration when mixed with other components. CCP and MgSt formed agglomerates over time and showed positive interactions favouring agglomeration. The agglomerates started to fracture when they reached a critical size, at which stage the particles' attraction forces (cohesion forces) were weaker than both gravity and inertia. It has been shown and quantitatively demonstrated that the mixing time and ingredient concentrations of a three-component pharmaceutical mixture can affect agglomeration tendency.
authors.affiliation: Department of Chemical Engineering, Université de Sherbrooke, Sherbrooke, Que., Canada.
authors.forename: Emilie DesRosiers
authors.initials: ED
authors.lastname: Lachiver
authors.forename: Nicolas
authors.initials: N
authors.lastname: Abatzoglou
authors.forename: Louis
authors.initials: L
authors.lastname: Cartilier
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Simard
mesh_terms: D000704:Analysis of Variance; D002119:Calcium Carbonate / Q000737:chemistry; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D015233:Models, Statistical; D010316:Particle Size; D013229:Stearic Acids / Q000737:chemistry; D014993:Xylitol / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D013229:Stearic Acids; C031183:stearic acid; D002119:Calcium Carbonate; D014993:Xylitol