Serum levels of angiogenic factors indicate a pro-angiogenic state in adults with sickle cell disease.
Hypoxia-induced angiogenesis may play an important role in the pathophysiology of sickle cell disease (SCD). Serum levels of angiopoietin (Ang)-1, Ang-2, vascular endothelial growth factor, placenta growth factor (PlGF), soluble tunica intima endothelial kinase 2 (sTIE2), erythropoietin (EPO) and endothelial activation markers (soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1) were determined in controls, HbSS (n = 35) and HbSC (n = 23) patients. In the asymptomatic phase, serum Ang-2 (P < 0.001), EPO (P < 0.001) and sTIE2 (P = 0.03) were elevated in patients. During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients. These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels.
Duits
Ashley J
AJ
Immunology Laboratory Department, Red Cross Blood Bank Foundation, Curaçao, Netherlands Antilles. aduits@attglobal.net
Rodriguez
Tati
T
Schnog
John-John B
JJ
D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000473:pathology; D043925:Angiogenesis Inducing Agents / Q000032:analysis*; D042683:Angiopoietin-1 / Q000097:blood; D042702:Angiopoietin-2 / Q000097:blood; D016022:Case-Control Studies; D004921:Erythropoietin / Q000097:blood; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D007958:Leukocyte Count; D009389:Neovascularization, Pathologic; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood; D042787:Receptor, TIE-2 / Q000097:blood; D018709:Statistics, Nonparametric; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D043925:Angiogenesis Inducing Agents; D042683:Angiopoietin-1; D042702:Angiopoietin-2; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D019010:Vascular Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D004921:Erythropoietin; D018799:Intercellular Adhesion Molecule-1; D000072483:Placenta Growth Factor; D005319:Fetal Hemoglobin; D042787:Receptor, TIE-2