HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?
HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
Baccar Harrath
Amal
A
Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, ElManar University, Tunis, 1060, Tunisia. amal.baccar@laposte.net
Yacoubi Loueslati
Besma
B
Troudi
Wafa
W
Hmida
Slama
S
Sedkaoui
Syrine
S
Dridi
Amel
A
Jridi
Afef
A
Ben Ayed
Farhat
F
Ben Rhomdhane
Khaled
K
Ben Ammar Elgaaied
Amel
A
D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control; D016022:Case-Control Studies; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D015994:Incidence; D015810:Linkage Disequilibrium / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II