[Possible genetic link between Darier's disease and depression. Review of the literature and case history].
Darier's disease is a rare, inherited autosomal dominant skin disorder caused by a mutation in the sarcoendoplasmatic reticulum calcium transporter (SERCA)-2-gene. In a number of pedigrees, Darier's disease closely relates with affective disorder. The most likely hypothesis for this is a susceptibility gene for affective disorder near the SERCA-2-gene. A 6.5-megabase region could be identified as a susceptibility locus. This region constitutes a susceptability locus also in affective disorder without Darier's disease. The underlying gene has not yet been identified.
Bach
D R
DR
Universitätsklinik für klinische Psychiatrie, Universität Bern.
Moggi
F
F
Müller
T J
TJ
Seifritz
E
E
Strik
W K
WK
Wirtz
G
G
D000328:Adult; D007644:Darier Disease / Q000453:epidemiology* / Q000235:genetics*; D003863:Depression / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors