title: [Modulation of reactivity of cyclic adenosine monophosphate phosphodiesterase under the effect of pyridinecarboxylic acid derivatives and Pt(IV) metal complexes on their basis].
abstract: The effect of substituted nicotinamides and isonicotinamides and Pt(IV) metal complexes based on the substituted nicotinamides and isonicotinamides on the activity of cAMP phosphodiesterase was studied. Isonicotinamide derivatives are efficient enzyme activators, whereas substituted nicotine amides are inhibitors of enzymatic cAMP phosphodiesterase activity; their inhibitory potency is comparable to that of theophylline used as a reference drug.
authors.forename: L V
authors.initials: LV
authors.lastname: Tat'ianenko
authors.forename: G N
authors.initials: GN
authors.lastname: Bogdanov
authors.forename: O V
authors.initials: OV
authors.lastname: Dobrokhotova
authors.forename: M A
authors.initials: MA
authors.lastname: Fadeev
authors.forename: B S
authors.initials: BS
authors.lastname: Fedorov
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000201:enzymology*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006868:Hydrolysis; D066298:In Vitro Techniques; D008024:Ligands; D009536:Niacinamide / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands; D009944:Organoplatinum Compounds; D011725:Pyridines; D009536:Niacinamide; C027681:isonicotinamide; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases