title: Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
abstract: Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.
authors.affiliation: Department of Organic Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, UKOX1 3TA. steve.davies@chem.ox.ac.uk
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Davies
authors.forename: A Christopher
authors.initials: AC
authors.lastname: Garner
authors.forename: Euan C
authors.initials: EC
authors.lastname: Goddard
authors.forename: Dennis
authors.initials: D
authors.lastname: Kruchinin
authors.forename: Paul M
authors.initials: PM
authors.lastname: Roberts
authors.forename: Humberto
authors.initials: H
authors.lastname: Rodriguez-Solla
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Smith