title: Local field potential spectral tuning in motor cortex during reaching.
abstract: In this paper, intracortical local field potentials (LFPs) and single units were recorded from the motor cortices of monkeys (Macaca fascicularis) while they preformed a standard three-dimensional (3-D) center-out reaching task. During the center-out task, the subjects held their hands at the location of a central target and then reached to one of eight peripheral targets forming the corners of a virtual cube. The spectral amplitudes of the recorded LFPs were calculated, with the high-frequency LFP (HF-LFP) defined as the average spectral amplitude change from baseline from 60 to 200 Hz. A 3-D linear regression across the eight center-out targets revealed that approximately 6% of the beta LFPs (18-26 Hz) and 18% of the HF-LFPs were tuned for velocity (p-value < 0.05), while 10% of the beta LFPs and 15% of the HF-LFPs were tuned for position. These results suggest that a multidegree-of-freedom brain-machine interface is possible using high-frequency LFP recordings in motor cortex.
authors.affiliation: Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
authors.forename: Dustin A
authors.initials: DA
authors.lastname: Heldman
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Sherwin S
authors.initials: SS
authors.lastname: Chan
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Moran
mesh_terms: D000818:Animals; D001132:Arm / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D000882:Haplorhini; D008251:Macaca; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D013647:Task Performance and Analysis; D014584:User-Computer Interface; D014796:Visual Perception / Q000502:physiology*