title: Intravenous fluid to prevent hypotension in patients undergoing elective colonoscopy.
abstract: Colonoscopy may be associated with hypotension during sedation leading to postoperative morbidity. However, no treatment is proven to ameliorate intraoperative hypotension for this procedure. We therefore conducted a randomized trial to determine the effect of intravenous fluid infusion on the incidence of hypotension during sedation for colonoscopy. With institutional approval, 160 patients presenting for elective colonoscopy were randomized to 1.5 ml/kg or 15 ml/kg Hartmann's solution before colonoscopy. All observers were blind to group allocation. The incidence of hypotension during sedation (29% vs 25%; P=0.59) and postoperative morbidity (nausea, vomiting, headache, drowsiness and dizziness) (41% vs 39%; P= 0.75) did not differ between the two groups. Hypotensive patients were older, had a higher baseline systolic blood pressure, and were thirstier after fluid infusion than normotensive patients. This study does not support the use of 15 ml/kg Hartmann's solution to reduce the incidence of hypotension or postoperative morbidity in patients undergoing elective colonoscopy.
authors.affiliation: Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Victoria, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Leslie
authors.forename: T
authors.initials: T
authors.lastname: Tay
authors.forename: E
authors.initials: E
authors.lastname: Neo
mesh_terms: D003113:Colonoscopy / Q000009:adverse effects*; D016292:Procedural Sedation / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D000077325:Ringer's Lactate; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000517:prevention & control
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate