title: Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.
abstract: CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
authors.affiliation: Department of Life Science, Research Center for Women's Diseases, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Kun-yong
authors.initials: KY
authors.lastname: Kim
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Jae Hyeong
authors.initials: JH
authors.lastname: Kim
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Do-Hyung
authors.initials: DH
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Han
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Lim
authors.forename: Dae Ho
authors.initials: DH
authors.lastname: Cho
authors.forename: Myeong-Sok
authors.initials: MS
authors.lastname: Lee
authors.forename: Sukjoon
authors.initials: S
authors.lastname: Yoon
authors.forename: Keun Il
authors.initials: KI
authors.lastname: Kim
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Yoon
authors.forename: Young
authors.initials: Y
authors.lastname: Yang
mesh_terms: D054392:Adipokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009765:Obesity; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011924:Rats, Zucker; D016415:Sequence Alignment; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D054392:Adipokines; C512356:C1QTNF1 protein, human; C512355:C1qtnf1 protein, rat; C570300:CTRP1 protein, mouse; D018076:DNA, Complementary; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011506:Proteins; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha