[Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy].
While 10% of healthy men had sexual dysfunctions, male epilepsy patients experience sexual problems in 40-70%. The cause of sexual dysfunction in epilepsy is multifactorial, but there are three main factors: the epilepsy itself, antiepileptic treatment and psychiatric/psychic problems. Antiepileptics with hepatic enzyme induction potential (carbamazepine, phenytoin) enhance the metabolism of sexual steroids. Valproic acid as an enzyme inhibitor and drug with high protein binding affinity elevates the free serum levels of androgens. Certain antiepileptic drugs may have negative cognitive side effects, some of them can induce psychiatric disorders. These drugs can facilitate male sexual dysfunctions through these psychic side effects. The metabolic and endocrine alterations caused by carbamazepine may return to normal level after replacement of carbamazepine with oxcarbazepine. After an oxcarbazepine-carbamazepine replacement, carbamazepine-induced impotency can be cured. According some new data lamotrigine can also help in sexual dysfunction. The therapy of sexual dysfunction in epilepsy depends on its cause. In cases of hormonal alterations, the fist step is a change of antiepileptic regimen. Instead of enzyme-inductor antiepileptics and valproate, new antiepileptic drugs should be prescribed. At present, the most investigated antiepileptic drug is the oxcarbazepine with positive effect on antiepileptic-induced male sexual dysfunction, however, lamotrigine seems to be also beneficial. If the hormonal and sexual dysfunctions cannot be eliminated by drug changes, androgenic therapy or bromocriptine may be required. Testosterone may not only be beneficial on sexual functions, but can reduce also the seizure frequency. Independent of etiology, erectile dysfunctions can be successfully treated by sildenafil.
Bóné
Beáta
B
Pécsi Tudományegyetem, Neurológiai Klinika, Pécs.
Janszky
József
J
D000728:Androgens / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D001971:Bromocriptine / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives; D003071:Cognition / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D000077213:Lamotrigine; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D000078330:Oxcarbazepine; D010672:Phenytoin / Q000009:adverse effects; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013739:Testosterone / Q000627:therapeutic use; D014227:Triazines / Q000009:adverse effects; D014635:Valproic Acid / Q000009:adverse effects
D000728:Androgens; D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D014227:Triazines; D002220:Carbamazepine; D001971:Bromocriptine; D013739:Testosterone; D014635:Valproic Acid; D010672:Phenytoin; D000077213:Lamotrigine; D000078330:Oxcarbazepine