[Severe ocular side effects with Topamax].
METHODS
We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks.


CONCLUSIONS
We identified two severe ocular adverse reactions from topiramate. Both reactions necessitated discontinuing the treatment, but the topiramate-associated maculopathy was irreversible.
Asensio-Sánchez
V M
VM
Hospital General, Medina del Campo, Valladolid, España. vasensio@hmdc.sacyl.es
Torreblanca-Agüera
B
B
Martínez-Calvo
S
S
Calvo
M J
MJ
Rodríguez
R
R
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001766:Blindness / Q000139:chemically induced*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006423:Hemianopsia / Q000139:chemically induced*; D006801:Humans; D008266:Macula Lutea; D012164:Retinal Diseases / Q000139:chemically induced*; D000077236:Topiramate; D014794:Visual Fields
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose