Isolation and identification of 5-methyl-imidazolin-4-one derivative as glyceraldehyde-derived advanced glycation end product.
We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and N(alpha)-acetylarginine. A major product was identified as N(alpha)-acetyl-N(delta)-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.
Usui
Teruyuki
T
Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Kawasaki, Kanagawa.
Watanabe
Hirohito
H
Hayase
Fumitaka
F
D002851:Chromatography, High Pressure Liquid; D017127:Glycation End Products, Advanced / Q000737:chemistry* / Q000302:isolation & purification*; D005985:Glyceraldehyde / Q000737:chemistry*; D048288:Imidazolines / Q000737:chemistry*; D015394:Molecular Structure
C512937:5-methyl-imidazolin-4-one; D017127:Glycation End Products, Advanced; D048288:Imidazolines; D005985:Glyceraldehyde