title: Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?
abstract: Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, INSERM U427 Paris, Faculté de Pharmacie, France. mehats@cochin.inserm.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Méhats
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz
authors.forename: Michelle
authors.initials: M
authors.lastname: Breuiller-Fouché
authors.forename: Marie-Josèphe
authors.initials: MJ
authors.lastname: Leroy
authors.forename: Dominique
authors.initials: D
authors.lastname: Cabrol
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011247:Pregnancy; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases