title: Laryngeal leiomyosarcoma: a case report and review of the literature.
abstract: Laryngeal leiomyosarcoma (LLM) is a rare malignancy originating from the smooth muscles of blood vessels or from aberrant undifferentiated mesenchymal tissue. Histological diagnosis may be particularly difficult and correct diagnosis is based on immunohistochemical investigations and electron microscopy. A case report of a LLM in a 74-year-old man is presented. Direct laryngoscopy revealed a large glottic lesion causing airway compromise and an emergency tracheotomy was performed. Subsequent total laryngectomy confirmed the diagnosis of leiomyosarcoma. Lung metastases developed 8 months following treatment, despite the absence of local or regional recurrence, and the patient died 3 months later. A review of the English and French literature revealed 30 previous cases of LLM. Clinical presentation, histological diagnosis, and management of this rare malignancy are analyzed aiming to improve our knowledge regarding the best treatment modality.
authors.affiliation: ENT Department, "Achillopoulion" General Hospital of Volos, 134 Polymeri Str, Volos, 38222, Greece.
authors.forename: Charalambos E
authors.initials: CE
authors.lastname: Skoulakis
authors.forename: Pelagia
authors.initials: P
authors.lastname: Stavroulaki
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Moschotzopoulos
authors.forename: Mihalis
authors.initials: M
authors.lastname: Paxinos
authors.forename: Angela
authors.initials: A
authors.lastname: Fericean
authors.forename: Dimitris E
authors.initials: DE
authors.lastname: Valagiannis
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007825:Laryngectomy; D007828:Laryngoscopy; D007890:Leiomyosarcoma / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male