A multivariate population density model of the dLGN/PGN relay.
Using a population density approach we study the dynamics of two interacting collections of integrate-and-fire-or-burst (IFB) neurons representing thalamocortical (TC) cells from the dorsal lateral geniculate nucleus (dLGN) and thalamic reticular (RE) cells from the perigeniculate nucleus (PGN). Each population of neurons is described by a multivariate probability density function that satisfies a conservation equation with appropriately defined probability fluxes and boundary conditions. The state variables of each neuron are the membrane potential and the inactivation gating variable of the low-threshold Ca2+ current I(T). The synaptic coupling of the populations and external excitatory drive are modeled by instantaneous jumps in the membrane potential of postsynaptic neurons. The population density model is validated by comparing its response to time-varying retinal input to Monte Carlo simulations of the corresponding IFB network composed of 100 to 1,000 cells per population. In the absence of retinal input, the population density model exhibits rhythmic bursting similar to the 7 to 14 Hz oscillations associated with slow wave sleep that require feedback inhibition from RE to TC cells. When the TC and RE cell potassium leakage conductances are adjusted to represent cholingergic neuromodulation and arousal of the network, rhythmic bursting of the probability density model may either persists or be eliminated depending on the number of excitatory (TC to RE) or inhibitory (RE to TC) connections made by each presynaptic cell. When the probability density model is stimulated with constant retinal input (10-100 spikes/sec), a wide range of responses are observed depending on cellular parameters and network connectivity. These include asynchronous burst and tonic spikes, sleep spindle-like rhythmic bursting, and oscillations in population firing rate that are distinguishable from sleep spindles due to their amplitude, frequency, or the presence of tonic spikes. In this context of dLGN/PGN network modeling, we find the population density approach using 2,500 mesh points and resolving membrane voltage to 0.7 mV is over 30 times more efficient than 1,000-cell Monte Carlo simulations.
Huertas
Marco A
MA
Department of Applied Science, College of William and Mary, Williamsburg, VA 23187, USA. greg@as.wm.edu
Smith
Gregory D
GD
D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005829:Geniculate Bodies / Q000502:physiology*; D006801:Humans; D020646:Intralaminar Thalamic Nuclei / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D009010:Monte Carlo Method; D015999:Multivariate Analysis; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012160:Retina / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
D007473:Ion Channels