New entry into beta-lactams via reaction of dimethoxycarbene with isocyanates.
[reaction: see text] Highly substituted beta-lactams have been isolated as the major product of the reaction of dimethoxycarbene with selected isocyanates. This reaction offers the potential for rapid access into a variety of highly functionalized species.
Rigby
James H
JH
Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA. jhr@chem.wayne.edu
Brouet
Jean-Christophe
JC
Burke
Patrick J
PJ
Rohach
Stephanie
S
Sidique
Shyama
S
Heeg
Mary Jane
MJ
D006838:Hydrocarbons / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D047090:beta-Lactams / Q000138:chemical synthesis*
D006838:Hydrocarbons; D017953:Isocyanates; D047090:beta-Lactams; C030011:carbene; D008697:Methane