Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.
We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.
Clancy
Cornelius J
CJ
North Florida/South Georgia VA Medical Center, University of Florida College of Medicine, Gainesville, FL 32610, USA. clancyn@medicine.ufl.edu
Huang
Hong
H
Cheng
Shaoji
S
Derendorf
Hartmut
H
Nguyen
M Hong
MH
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D000077336:Caspofungin; D015169:Colony Count, Microbial; D054714:Echinocandins; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000592:standards; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013997:Time Factors
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin