Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters.
The present study compared the hypolipidemic activity of kudzu phytoestrogens with that of soybean phytoestrogen in estrogen- and androgen-deficient hamsters. In the first experiment, ovariectomized hamsters (n = 37) were randomly divided into four groups (n = 9-10 each group). The first group was the control group, whereas the second group had the time-releasing estradiol-17beta subcutaneous (pellet) implants as a positive control. The third and fourth groups were orally administered soybean or kudzu phytoestrogen extracts (30 mg/kg of body weight) per day. In the second experiments, the first group of male hamsters (n = 9) received a sham operation, whereas the other three groups of male hamsters (n = 9 each) were castrated. The castrated control group received orally distilled water, whereas the second and third castrated groups were orally given 30 mg/kg soybean or kudzu phytoestrogen extracts. The results for the first experiment showed that the ovariectomized hamsters orally given soybean and kudzu phytoestrogen extracts had significantly decreased serum total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) with HDL cholesterol (HDL-C) being unaffected. The data from the second experiment demonstrated that administration of soybean but not kudzu phytoestrogen extracts decreased significantly serum TC. However, administration of kudzu phytoestrogens caused redistribution of cholesterol among lipoproteins, leading to a significant decrease in the ratio of non-HDL-C to HDL-C. It was concluded that both soybean and kudzu phytoestrogens could modify favorably lipoprotein profiles in ovariectomized and castrated hamsters.
Guan
Lei
L
Li Ka Shing Institute of Health Sciences, Food and Nutritional Sciences Program of the Department of Biochemistry, and Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Yeung
Sai Ying Venus
SY
Huang
Yu
Y
Chen
Zhen-Yu
ZY
D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D006224:Cricetinae; D005260:Female; D007668:Kidney / Q000737:chemistry; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000737:chemistry; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000737:chemistry; D009919:Orchiectomy; D010052:Ovariectomy; D048789:Phytoestrogens / Q000494:pharmacology*; D029908:Pueraria / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D048789:Phytoestrogens; D014280:Triglycerides; D002784:Cholesterol