Gastroretentive Accordion Pill: Enhancement of riboflavin bioavailability in humans.
The purpose of this study was to evaluate the ability of the Accordion Pill (AP), a novel controlled release gastroretentive unfolding dosage form (DF), to increase the bioavailability of riboflavin (RF) in humans. Three formulations containing 75 mg of RF and differing in release rate (immediate release (IR) capsule, AP#1, and AP#2) were administered with a low-calorie meal. Gastric residence time (GRT) of the AP was assessed by magnetic resonance imaging. Serial blood and urine samples were taken and assayed for RF. The AP demonstrated prolonged (up to 10.5 h) GRT in humans. Significant elevation in RF bioavailability (209+/-37%, mean+/-S.E.) was achieved by the AP#1 in comparison to the IR capsule. A correlation was established between the in-vitro release rates from DF and bioavailability of RF in humans, and it was modeled taking into account the saturable nature of RF absorption transport and its narrow absorption window (NAW) in the upper gastro-intestinal tract. It is anticipated that the AP will provide a valuable pharmaceutical solution to enhance therapy with NAW drugs.
Kagan
Leonid
L
Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel.
Lapidot
Noa
N
Afargan
Michel
M
Kirmayer
David
D
Moor
Eytan
E
Mardor
Yael
Y
Friedman
Michael
M
Hoffman
Amnon
A
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D005260:Female; D052203:Ferrosoferric Oxide; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000378:metabolism*; D005772:Gastrointestinal Transit; D006801:Humans; D007202:Indicators and Reagents; D008279:Magnetic Resonance Imaging; D008297:Male; D012256:Riboflavin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
D002214:Capsules; D003692:Delayed-Action Preparations; D007202:Indicators and Reagents; D014803:Vitamin B Complex; D012256:Riboflavin; D052203:Ferrosoferric Oxide