Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics.
There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone characteristics in young, adult, and aged long-lived GH receptor knockout (GHR-KO) and normal mice to determine the effects of GH resistance during aging. Compared to controls, GHR-KO mice showed an increased percentage of body fat. GHR-KO mice have reduced total-body bone mineral density (BMD), bone mineral content, and bone area, but these parameters increased with age. In addition, GHR-KO mice have decreased femur length, femur BMD, and lower lumbar BMD compared to controls in all age groups. These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice.
Bonkowski
Michael S
MS
Department of Physiology and Internal Medicine-Geriatrics Research, Southern Illinois University School of Medicine, Springfield. IL 62794-9628, USA. mbonkowski@siumed.edu
Pamenter
Richard W
RW
Rocha
Juliana S
JS
Masternak
Michal M
MM
Panici
Jacob A
JA
Bartke
Andrzej
A
D015502:Absorptiometry, Photon; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011986:Receptors, Somatotropin / Q000378:metabolism*
D011986:Receptors, Somatotropin