Relationship between event-related potentials and frontal-subcortical dysfunction in Parkinson's disease.
Cognitive impairment in Parkinson's disease (PD) has been determined to be due to the interruption of frontal-subcortical neural circuits. To evaluate which kind of frontal-subcortical dysfunction may be present and the relationship of this dysfunction with P300 in PD patients, non-demented PD patients and controls were rendered for comprehensive Frontal Test Battery and P300 assessments. PD patients manifested significantly with frontal dysfunction and revealed a good correlation between P300 and executive dysfunction. We conclude that PD patients may manifest with cognitive impairment related to frontal dysfunction, and P300 may be an indicator reflecting the evolution of dysexecutive syndrome.
Chen
Kuan-Jen
KJ
Graduate Institute of Behavioral Sciences and Department of Neurology, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Lin
Ruey-Tay
RT
Liu
Ching-Kuan
CK
Tai
Chih-Ta
CT
Lai
Chiou-Lian
CL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000166:cytology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology*; D018913:Event-Related Potentials, P300; D005260:Female; D005625:Frontal Lobe / Q000166:cytology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology*