Developments in the use of chemoradiotherapy in rectal cancer.
This paper reviews the current evidence available from phase III trials of combination pre-operative chemoradiotherapy (CRT) in the treatment of rectal cancer. There is clear evidence that CRT is superior to long-course radiotherapy (LRT). However, the end-points and definitions used must be standardized for future clinical trials of combination CRT.
Sebag-Montefiore
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Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, UK. david.sebag-montefiore@leedsth.nhs.uk
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003082:Colectomy / Q000379:methods; D003131:Combined Modality Therapy; D006801:Humans; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery