An improved route to the synthetic of diphenyl alpha-(diethoxythiophosphorylamino)methylphosphonates.
An improved method for the synthesis of Diphenyl alpha-(diethoxythiophosphorylamino)methylphosphonates under mild conditions is described. It consists of the reaction of diethyl thiophosphoramidate (1) with triphenyl phosphite (3) and a substituted benzylaldehyde or ketone (2) by a one-pot procedure with the aid of acetyl chloride.
Miao
Zhiwei
Z
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China. miaozhiwei@nankai.edu.cn
Wang
Bin
B
Zhang
Gaihong
G
Chen
Ruyu
R