title: The burden of age-related macular degeneration: a value-based analysis.
abstract: OBJECTIVE
  The quality-of-life loss and the financial consequences associated with age-related macular degeneration are assessed.
  
  
  RESULTS
  The quality-of-life loss associated with macular degeneration is markedly underestimated by the general public, nonophthalmic physicians, and ophthalmologists who treat patients with this condition. Mild age-related macular degeneration causes a 17% decrement in the quality of life of the average patient, similar to that encountered with moderate cardiac angina or symptomatic human immunodeficiency virus syndrome. Moderate age-related macular degeneration causes a 40% decrease in the average patient's quality of life, similar to that associated with severe cardiac angina or renal dialysis. Very severe age-related macular degeneration causes a large 63% decrease in the average patient's quality of life, similar to that encountered with end-stage prostatic cancer or a catastrophic stroke that leaves a person bedridden, incontinent and requiring constant nursing care. The return on investment is high for both treatment with current age-related macular degeneration therapies and the research costs invested in the development of age-related macular degeneration treatment modalities.
  
  
  CONCLUSIONS
  Age-related macular degeneration is a major public health problem that has a devastating effect upon patients and marked adverse financial consequences for the economy.
authors.affiliation: Center for Value-Based Medicine, Flourtown 19031, USA. mbrown@valuebasedmedicine.com
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Brown
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sharma
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Stein
authors.forename: Zachary
authors.initials: Z
authors.lastname: Roth
authors.forename: Joseph
authors.initials: J
authors.lastname: Campanella
authors.forename: George R
authors.initials: GR
authors.lastname: Beauchamp
mesh_terms: D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D019317:Evidence-Based Medicine; D017048:Health Care Costs; D006801:Humans; D008268:Macular Degeneration / Q000191:economics*; D011788:Quality of Life