title: [Study on the association between transforming growth factor alpha gene TaqI variant and cleft lip with or without cleft palate].
abstract: OBJECTIVE
  To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population.
  
  
  METHODS
  TGFalpha TaqI variant was detected using polymerase chain reaction-restriction fragment length polymorphism for DNA samples of the 149 triads with nsCL/P affected child. We performed the Transmission/disequilibrium test and the family-based association study (FBAT) to identify the associations between this variant and risk of nsCL/P.
  
  
  RESULTS
  Significant distortion of C2 allele at TGFalpha TaqI locus in nsCL/P groups (P > 0.05) was not found. In the family-based association test, C2 allele and offspring C2C1 genotype was not found to be significantly associated with an increase risk of nsCL/P (P > 0.05).
  
  
  CONCLUSIONS
  Our findings did not suggest an association between offspring TGFalpha TaqI variant and the increased risk of nsCL/P in Chinese population.
authors.affiliation: Institute of Reproductive and Child Health, National Reference Laboratory on Reproductive Health Research Ministry of Health, Peking University, Beijing 100083, China.
authors.forename: Jiang-hui
authors.initials: JH
authors.lastname: Zhu
authors.forename: Ai-guo
authors.initials: AG
authors.lastname: Ren
authors.forename: Ling
authors.initials: L
authors.lastname: Hao
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Pei
authors.forename: Bo-lan
authors.initials: BL
authors.lastname: Zhang
authors.forename: Min-xia
authors.initials: MX
authors.lastname: Zhou
authors.forename: Xia-mei
authors.initials: XM
authors.lastname: Sun
authors.forename: Mei-fang
authors.initials: MF
authors.lastname: Jiang
authors.forename: Hai-lan
authors.initials: HL
authors.lastname: Chen
authors.forename: Zhu
authors.initials: Z
authors.lastname: Li
mesh_terms: D002648:Child; D002681:China; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk; D016211:Transforming Growth Factor alpha / Q000235:genetics*
chemical_list: D016211:Transforming Growth Factor alpha