title: Does reduction mammaplasty improve lung function test in women with macromastia? Results of a randomized controlled trial.
abstract: BACKGROUND
  To determine the effects of reduction mammaplasty on lung function in women with mammary hypertrophy (macromastia), a prospective, randomized, controlled trial was conducted at the Academic Surgery and Plastic Surgery Units, Castle Hill Hospital, Cottingham, United Kingdom.
  
  
  METHODS
  Seventy-three women who were referred for consideration of bilateral breast reduction surgery were randomized into either an early intervention group (surgery within 6 weeks) or a control group (surgery 6 months after recruitment). Each group had two sets of lung function tests: the intervention group had one before and one 3 months after surgery and the control arm had one test initially and a second test 4 months after randomization and before surgery. The main outcome measure was the lung function test.
  
  
  RESULTS
  Sixty-five patients completed the study. The mean age was 39 years (SD, 12 years); both groups were equally matched for age, smoking status, social class, and educational status. By independent t test, there was no significant difference in lung function in the two groups. Subgroup analysis of the intervention group demonstrated a positive correlation between specimen weight and forced expiratory volume/vital capacity, forced expiratory volume/forced vital capacity, peak expiratory flow rate, and forced vital capacity. A paired sample t test revealed a significant improvement in the percentage of forced vital capacity performed/forced vital capacity predicted.
  
  
  CONCLUSIONS
  The improvement in pulmonary function following reduction mammaplasty correlates with specimen weight resected.
authors.affiliation: Academic Surgery Unit, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, United Kingdom. obiukwu@hotmail.com
authors.forename: Obi C
authors.initials: OC
authors.lastname: Iwuagwu
authors.forename: Alistair J
authors.initials: AJ
authors.lastname: Platt
authors.forename: Paul W
authors.initials: PW
authors.lastname: Stanley
authors.forename: Nick B
authors.initials: NB
authors.lastname: Hart
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Drew
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D016462:Mammaplasty; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D012129:Respiratory Function Tests