[Comparison of the methods of evaluation of the microbiological danger of antimicrobial agents by the example of oligo- and polyguanidines].
The article contains the results of comparison of the methods of evaluation of the microbiological danger of antimicrobial agents by the example of oligo- and polyguanidines. The study demonstrates that choice of an adequate study model (a bacterial or protozoa species) and exposure time depends on the characteristics of the preparation to be tested. It shows that the microbocide activity of polyguanidines should be studied on a bacterial model using long (24 hours) exposure. The most sensitive to XG6 was a protozoa culture in short-time exposure. To evaluate the biological danger ofantimicrobial agents, it is also possible to apply techniques that allow revealing reversable physiological changes in a culture of test objects.
Timofeeva
M Iu
MIu
Bogdanova
E A
EA
Vorob'ev
A A
AA
Nesvizhskiĭ
Iu V
IuV
Ivanova
L V
LV
Matiushina
G P
GP
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial; D004785:Environmental Pollutants / Q000009:adverse effects*; D056890:Eukaryota / Q000187:drug effects* / Q000254:growth & development; D006146:Guanidines / Q000009:adverse effects*; D066298:In Vitro Techniques; D012307:Risk Factors
D000890:Anti-Infective Agents; D004785:Environmental Pollutants; D006146:Guanidines