title: [Preliminary study of gene expression profiling in human type I and II endometrial carcinoma].
abstract: OBJECTIVE
  To study gene expression profiling in human type I and II endometrial carcinoma.
  
  
  METHODS
  Six Affymetrix human genome genechips were utilized to investigate the differences in gene expression profiles between type I and II endometrial carcinoma with bioinformatic analysis.
  
  
  RESULTS
  Many genes were highly expressed in estrogen-dependent endometrial carcinoma, and some of them were involved in the metabolism and conversion of estrogen, while some others in estrogen regulation. CYP2C9, for instance, was involved in the conversion of estrogen sulfate to 16-hydroxy sulfate metabolite, DDC in estrogen-dependent pathogenesis of endometrial carcinoma possibly by DDC interaction with AR to enhance steroid receptor transcription.
  
  
  CONCLUSIONS
  High expression of these genes in estrogen-dependent endometrial carcinoma may provide insights into their roles in the pathogenesis and prognosis of this malignancy.
authors.affiliation: Department of Gynaecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. guosq@fimmu.com
authors.forename: Sui-qun
authors.initials: SQ
authors.lastname: Guo
authors.forename: Fu-qi
authors.initials: FQ
authors.lastname: Xing
authors.forename: Zhan-jun
authors.initials: ZJ
authors.lastname: Pang
authors.forename: Wei-yi
authors.initials: WY
authors.lastname: Fang
authors.forename: Guo-bing
authors.initials: GB
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D046228:Microarray Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction