Effect of UV Light on RNA-Directed DNA Polymerase Activity of Murine Oncornaviruses.
The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 x 10(4) to 3.1 x 10(4) ergs/mm(2). The inactivation rate of p30, a major internal viral protein, was much slower.
Lovinger
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Flow Laboratories, Inc., Rockville, Maryland 20852.
Ling
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HP
Gilden
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RV
Hatanaka
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