title: Thyroid follicular carcinoma metastasized to the lung, skull, and brain 12 years after initial treatment for thyroid gland--case report.
abstract: A 65-year-old woman presented with multiple metastases from thyroid follicular carcinoma to the lung, skull, and brain. The skull and brain tumors had been successfully treated by surgery, thyroxine supplementation, and radiosurgery until she died of sudden intracerebral hemorrhage which had no connection with tumor treatment. The lung tumor was treated by conventional irradiation and radioactive ablation. Well-differentiated thyroid carcinoma is a slowly progressive tumor. Follicular carcinoma is thought to have the most optimistic prognosis even with metastases to the lymph nodes and lung. Radioactive ablation using iodine-131 is widely used to treat the primary and/or metastatic lesion. However, the prognosis for patients with brain metastases is poor. Intracranial metastasis of this tumor is rare, but has a mean posttreatment survival of around 12 months. Surgical excision of the metastatic intracranial lesion may be the only effective treatment.
authors.affiliation: Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka, Iwate. yogawa@kohan-sendai.or.jp
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugawara
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Seki
authors.forename: Tutomu
authors.initials: T
authors.lastname: Sakuma
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000473:pathology; D003131:Combined Modality Therapy; D015174:Epidural Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D009777:Occipital Bone / Q000473:pathology / Q000601:surgery; D009778:Occipital Lobe / Q000473:pathology / Q000601:surgery; D010294:Parietal Bone / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000473:pathology*; D016634:Radiosurgery; D012888:Skull Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D013965:Thyroidectomy; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D007457:Iodine Radioisotopes; D013974:Thyroxine