Integrating adhesion, protrusion, and contraction during cell migration.
Cell migration is fastest when the strength of the adhesion between the cell and the substrate is neither too strong nor too weak. In this issue of Cell, reveal how adhesion and cytoskeletal dynamics are integrated to optimize migration speed.
Schwartz
Martin A
MA
Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. maschwartz@virginia.edu
Horwitz
Alan Rick
AR
D000199:Actins / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D015398:Signal Transduction; D013499:Surface Properties
D000199:Actins; D005353:Fibronectins; D016023:Integrins