title: Small molecule inhibitors of IgE synthesis.
abstract: A novel series of small molecule inhibitors of IgE synthesis are described. Compounds were optimized for potency, metabolic stability and absence of genetic toxicology.
authors.affiliation: Discovery Chemistry, Pfizer Global Research and Development, Sandwich, UK. Alan.D.Brown@pfizer.com
authors.forename: Alan
authors.initials: A
authors.lastname: Brown
authors.forename: Alan
authors.initials: A
authors.lastname: Henderson
authors.forename: Charlotte
authors.initials: C
authors.lastname: Lane
authors.forename: Mark
authors.initials: M
authors.lastname: Lansdell
authors.forename: Graham
authors.initials: G
authors.lastname: Maw
authors.forename: Sandy
authors.initials: S
authors.lastname: Monaghan
mesh_terms: D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D020128:Inhibitory Concentration 50; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D015394:Molecular Structure; D008970:Molecular Weight; D009930:Organic Chemicals / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D009930:Organic Chemicals; D007073:Immunoglobulin E; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2