[Role of B-cell-activating-factor in immune regulation--review].
B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors: BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
Du
Jian-Fang
JF
Department of Molecular Genetics, Institue of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850 China.
Wang
Jia-Xi
JX
Xu
Dong-Gang
DG
D053264:B-Cell Activating Factor / Q000276:immunology*; D053265:B-Cell Activation Factor Receptor / Q000276:immunology; D053301:B-Cell Maturation Antigen / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007109:Immunity; D053303:Transmembrane Activator and CAML Interactor Protein / Q000276:immunology
D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D053301:B-Cell Maturation Antigen; D053303:Transmembrane Activator and CAML Interactor Protein