title: Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report.
abstract: Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed.
authors.affiliation: Laboratory of Clinical and Experimental Pathology and Human Tissue Biobank Unit, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002 Nice, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Butori
authors.forename: Véronique
authors.initials: V
authors.lastname: Hofman
authors.forename: Rita
authors.initials: R
authors.lastname: Attias
authors.forename: Jerôme
authors.initials: J
authors.lastname: Mouroux
authors.forename: Florence
authors.initials: F
authors.lastname: Pedeutour
authors.forename: Paul
authors.initials: P
authors.lastname: Hofman
mesh_terms: D000368:Aged; D002887:Chromosomes, Human, Pair 18; D041321:Chromosomes, Human, X; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic