Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.
Ptprj is a ubiquitously expressed murine gene encoding a receptor-type protein tyrosine phosphatase, which has recently been proposed as a candidate gene on the locus Scc1 for colon cancer susceptibility. It has been demonstrated that PTPRJ, the human homologue of Ptprj, is involved in the control of cell growth and adhesion, being furthermore altered in several types of cancer including mammary, thyroid, lung, colon, and pancreatic cancers. To investigate the biological functions of Ptprj, we have generated mice deficient in this receptor protein tyrosine phosphatase. Ptprj-deficient mice are viable, fertile, and show no gross anatomical alterations. Furthermore, neither changes in life span nor spontaneous tumor appearance were observed in Ptprj-null mice. Our results indicate that Ptprj is dispensable for normal growth and development in mice.
Trapasso
Francesco
F
Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro, Campus Germaneto, Catanzaro, Italy.
Drusco
Alessandra
A
Costinean
Stefan
S
Alder
Hansjuerg
H
Aqeilan
Rami I
RI
Iuliano
Rodolfo
R
Gaudio
Eugenio
E
Raso
Cinzia
C
Zanesi
Nicola
N
Croce
Carlo M
CM
Fusco
Alfredo
A
D000818:Animals; D015153:Blotting, Western; D002455:Cell Division / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D051379:Mice; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3
D017931:DNA Primers; D017027:Protein Tyrosine Phosphatases; C098066:Ptprj protein, mouse; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3