Transformation of an irregularly bridged epidithiodiketopiperazine to trichodermamide A.
[reaction: see text] An unusually bridged epidithiodiketopiperazine, pretrichodermamide A (3), was isolated from the fungus Trichoderma sp. BCC 5926. During the extensive effort to crystallize 3 for X-ray crystallographic analysis, conversion of this compound to trichodermamide A with coproduction of S(8) occurred.
Seephonkai
Prapairat
P
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Kongsaeree
Palangpon
P
Prabpai
Samran
S
Isaka
Masahiko
M
Thebtaranonth
Yodhathai
Y
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification*; D014242:Trichoderma / Q000737:chemistry*
D000995:Antitubercular Agents; D004151:Dipeptides; D010879:Piperazines; C519044:pretrichodermamide A; C476747:trichodermamide A; C036710:gliovirin