title: Chirality multiplication and efficient chirality transfer in exo- and endo-radical cyclization reactions of 4-(4'-iodobutyl)quinolones.
abstract: [reaction: see text] Enantioselective radical cyclization reactions were performed in the presence of chiral complexing agent 1. The title compounds 3 yielded, depending on the 3'-substitution (R = H, Me), the corresponding endo- (4) or exo-product (5). The highest enantioselectivities (99% and 94% ee) were achieved with 2.5 equiv of complexing agent. The cyclization product trans-4 was obtained in 55% ee in the presence of only 0.1 equiv of complexing agent.
authors.affiliation: Lehrstuhl für Organische Chemie I, Technische Universität München, Garching, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Dressel
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bach