Applications of asymmetric hydrosilylations mediated by catalytic (DTBM-SEGPHOS)CuH.
[reaction: see text] Several aryl ketone precursors useful in the synthesis of known physiologically active compounds have been reduced to the corresponding nonracemic alcohols. The previously reported combination of a catalytic quantity of (R)-(-)-DTBM-SEGPHOS-ligated CuH and stoichiometric PMHS is shown to be very effective in these asymmetric hydrosilylations.
Lipshutz
Bruce H
BH
Department of Chemistry & Biochemistry, University of California, Santa Barbara, 93106, USA. lipshutz@chem.ucsb.edu
Lower
Asher
A
Kucejko
Robert J
RJ
Noson
Kevin
K