title: Design and synthesis of novel chemokine analogs derived from vMIP-II.
abstract: Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.
authors.affiliation: Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Santhosh
authors.initials: S
authors.lastname: Kumar
authors.forename: Won-Tak
authors.initials: WT
authors.lastname: Choi
authors.forename: Changzhi
authors.initials: C
authors.lastname: Dong
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000595:Amino Acid Sequence; D054407:Chemokine CCL4; D018925:Chemokines / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: D054407:Chemokine CCL4; D018925:Chemokines; D019402:Macrophage Inflammatory Proteins; D014764:Viral Proteins