title: Recent progress in development of non-ATP competitive small-molecule inhibitors of protein kinases.
abstract: The majority of marketed and late stage development kinase inhibitors are reported to be ATP-competitive. As a result, many promising drug candidates display non-specific activity that results in undesired physiological effects. There is growing interest towards non-ATP competitive kinase inhibitors, as they are expected to yield highly specific and efficacious molecules devoid of non-mechanistic toxicity. Recent developments in this area are summarized in our review.
authors.affiliation: ChemDiv, Inc., San Diego, CA 92121, USA. ask@chemdiv.com
authors.forename: Alex
authors.initials: A
authors.lastname: Kiselyov
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Balakin
authors.forename: Sergey E
authors.initials: SE
authors.lastname: Tkachenko
authors.forename: Nikolay P
authors.initials: NP
authors.lastname: Savchuk
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D001667:Binding, Competitive; D015195:Drug Design; D006801:Humans; D011487:Protein Conformation; D047428:Protein Kinase Inhibitors / Q000737:chemistry*; D011494:Protein Kinases / Q000737:chemistry* / Q000187:drug effects*
chemical_list: D047428:Protein Kinase Inhibitors; D000255:Adenosine Triphosphate; D011494:Protein Kinases