title: DeltaNp63 protein expression in uterine cervical and endometrial cancers.
abstract: OBJECTIVE
  To investigate the significance of p63 expression in uterine cervical and endometrial cancers.
  
  
  METHODS
  DeltaNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included.
  
  
  RESULTS
  In uterine cervix, the expression of DeltaNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component.
  
  
  CONCLUSIONS
  Immunohistochemical staining for DeltaNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.
authors.affiliation: Department of Pathology, Yanbian University College of Medicine, Yanji, People's Republic of China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Lin
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Liu
authors.forename: Zhuhu
authors.initials: Z
authors.lastname: Li
authors.forename: Changheon
authors.initials: C
authors.lastname: Kim
authors.forename: Eungseok
authors.initials: E
authors.lastname: Lee
authors.forename: Insun
authors.initials: I
authors.lastname: Kim
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000943:Antigens, Differentiation / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002584:Cervix Uteri / Q000166:cytology / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry; D015534:Trans-Activators / Q000096:biosynthesis*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D000943:Antigens, Differentiation; D004268:DNA-Binding Proteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins