Naproxen-induced lichen planus: report of 55 cases.
BACKGROUND
Clinical and histopathological differential diagnosis is usually impossible in drug-induced lichen planus (LP) and idiopathic LP. Naproxen is a nonsteroidal anti-inflammatory drug, which is widely used for its analgesic, antipyretic and anti-inflammatory effects. To the best of our knowledge, two case reports on naproxen-induced LP have been reported.


METHODS
Fifty-five patients with LP, and a history of naproxen intake before their eruption, were investigated.


RESULTS
Twenty-five patients (45.5%) had a history of naproxen intake prior to their eruption without any other medication. Twelve patients (21.8%) had a history of simultaneous use of naproxen with other drugs that were reported as inducers of LP. Eighteen patients (32.7%) had given a history of using naproxen together with drugs that had not been previously reported as inducers of LP. Moreover, in 42 patients, eruptive-type LP development after naproxen intake, is an interesting observation. New lesions were not observed after the cessation of naproxen intake in any of the patients.


CONCLUSIONS
Naproxen might be accepted as an important inducer for LP, especially for the eruptive form.
Güneş
Ali Tahsin
AT
Department of Dermatology, Faculty of Medicine, University of Dokuz Eylül, Izmir, Turkey.
Fetil
Emel
E
Ilknur
Turna
T
Birgin
Bahar
B
Ozkan
Sebnem
S
D000293:Adolescent; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen