Diffusion tensor imaging and fiber-tracking in Marchiafava-Bignami disease.
Marchiafava-Bignami disease, a rare disorder most commonly seen in patients with a history of alcohol consumption, involves demyelination and subsequent necrosis of the corpus callosum. Diffusion tensor imaging demonstrates regional abnormalities in the corpus callosum that are not evident by conventional magnetic resonance imaging (MRI). Furthermore, fiber-tracking demonstrates significant disruption of axonal fiber bundles within the corpus callosum, most marked within the body, corresponding to the clinical finding of interhemispheric disconnection, which is characteristic of the disease.
Sair
Haris I
HI
Department of Diagnostic Imaging and Neurology, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA.
Mohamed
Feroze B
FB
Patel
Sunil
S
Kanamalla
Uday S
US
Hershey
Beverly
B
Hakma
Zakaria
Z
Faro
Scott H
SH
D020751:Alcohol-Induced Disorders / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged