title: Functional anatomy of the therapeutic effects of prism adaptation on left neglect.
abstract: OBJECTIVE
  To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke.
  
  
  METHODS
  In a functional imaging PET study, we used a covariation analysis to examine linear changes of regional cerebral blood flow over sessions as a function of left neglect improvement.
  
  
  RESULTS
  The network of significant brain regions associated with improvement of left neglect performance produced by prism adaptation involved the right cerebellum, the left thalamus, the left temporo-occipital cortex, the left medial temporal cortex, and the right posterior parietal cortex.
  
  
  CONCLUSIONS
  Our results suggest that the realignment of visuomotor coordinates is processed by the cerebellum and that low level sensorimotor adaptation actively modulates cerebral areas, albeit now relying on intact cerebellocerebral connections. Hence, our data support the hypothesis that the beneficial effect of prism adaptation on the clinical presentation of left neglect derives from modulation of cortical regions implicated in spatial cognition.
authors.affiliation: INSERM Unité 534, Espace et Action, 16, Avenue du doyen Lépine, 69500 Bron, France.
authors.forename: J
authors.initials: J
authors.lastname: Luauté
authors.forename: C
authors.initials: C
authors.lastname: Michel
authors.forename: G
authors.initials: G
authors.lastname: Rode
authors.forename: L
authors.initials: L
authors.lastname: Pisella
authors.forename: S
authors.initials: S
authors.lastname: Jacquin-Courtois
authors.forename: N
authors.initials: N
authors.lastname: Costes
authors.forename: F
authors.initials: F
authors.lastname: Cotton
authors.forename: D
authors.initials: D
authors.lastname: le Bars
authors.forename: D
authors.initials: D
authors.lastname: Boisson
authors.forename: P
authors.initials: P
authors.lastname: Halligan
authors.forename: Y
authors.initials: Y
authors.lastname: Rossetti
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007909:Lenses; D008297:Male; D010468:Perceptual Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation*; D049268:Positron-Emission Tomography; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome