title: Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.
abstract: Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample.
authors.affiliation: Department of Neurodegenerative Diseases, Hertie-Institute for Brain Research, Eberhard-Karls University, Tuebingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Fernández-Santiago
authors.forename: M
authors.initials: M
authors.lastname: Sharma
authors.forename: J C
authors.initials: JC
authors.lastname: Mueller
authors.forename: H
authors.initials: H
authors.lastname: Gohlke
authors.forename: T
authors.initials: T
authors.lastname: Illig
authors.forename: J
authors.initials: J
authors.lastname: Anneser
authors.forename: C
authors.initials: C
authors.lastname: Münch
authors.forename: A
authors.initials: A
authors.lastname: Ludolph
authors.forename: C
authors.initials: C
authors.lastname: Kamm
authors.forename: T
authors.initials: T
authors.lastname: Gasser
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D005858:Germany / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D013223:Statistics as Topic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A