title: 3-Methyl-4-chlorophenol for prion decontamination of medical devices.
abstract: Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrP(Sc) sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.
authors.affiliation: Robert-Koch-Institut, Nordufer, Germany.
authors.forename: Constanze
authors.initials: C
authors.lastname: Riemer
authors.forename: Theresa
authors.initials: T
authors.lastname: Bamme
authors.forename: Simon Wing Fai
authors.initials: SW
authors.lastname: Mok
authors.forename: Michael
authors.initials: M
authors.lastname: Baier
mesh_terms: D015153:Blotting, Western; D002733:Chlorophenols; D004202:Disinfectants; D004864:Equipment and Supplies; D011328:Prions
chemical_list: C515248:3-methyl-4-chlorophenol; D002733:Chlorophenols; D004202:Disinfectants; D011328:Prions