title: New antiviral agents.
abstract: During the last three decades, a better understanding of viral replication and disease states caused by viral infections have led to the development of newer antiviral agents with enhanced activity and better tolerability. This review focuses on newer systemic and topical antiviral agents that are used in treatment of herpes viruses including herpes simplex type-1 (HSV-1) and type-2 (HSV-2), varicella-zoster virus (VZV) and cytomegalovirus CMV) as well as the human papilloma virus (HPV). Included in this article are the agents famciclovir, penciclovir, valganciclovir, imiquimod, docosanole and brivudin.
authors.affiliation: Division of Infectious Diseases, Children's Hospital of Michigan, Carman and Ann Adams, Department of Pediatrics, Wayne State University, School of Medicine, Detroit 48201, USA. nabdel@dmc.org
authors.forename: Nahed
authors.initials: N
authors.lastname: Abdel-Haq
authors.forename: Pimpanada
authors.initials: P
authors.lastname: Chearskul
authors.forename: Hossam
authors.initials: H
authors.lastname: Al-Tatari
authors.forename: Basim
authors.initials: B
authors.lastname: Asmar
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000634:Aminoquinolines / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077595:Famciclovir; D005233:Fatty Alcohols / Q000627:therapeutic use; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D006147:Guanine; D006801:Humans; D000077271:Imiquimod; D000077562:Valganciclovir; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000634:Aminoquinolines; D000998:Antiviral Agents; D005233:Fatty Alcohols; C020235:brivudine; C053539:penciclovir; D015075:2-Aminopurine; D006147:Guanine; C529236:docosanol; D001973:Bromodeoxyuridine; D000077562:Valganciclovir; D000077271:Imiquimod; D015774:Ganciclovir; D000077595:Famciclovir; D000212:Acyclovir