Understanding mouse models of disease through metabolomics.
Metabolomics is widely applicable to a number of fields including toxicology, plant metabolism and functional genomics. In the area of functional genomics, a number of studies have demonstrated the potential of this approach, which combines high-throughput metabolite profiling with computer-assisted pattern recognition approaches. In this review, recent applications of metabolomics to understanding mouse models of disease are considered. This includes studies on the impact of mouse strain on disease models, as well as metabolic profiling of cardiovascular, metabolic and neurodegenerative diseases. This versatile tool is set to increase in popularity as functional genomic approaches produce more mouse models for phenotyping.
Griffin
Julian L
JL
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK. jlg40@mole.bio.cam.ac.uk
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D004195:Disease Models, Animal; D023281:Genomics / Q000379:methods*; D008659:Metabolic Diseases / Q000378:metabolism; D051379:Mice / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D040901:Proteomics / Q000379:methods*