Heterotopic inputs facilitate poststimulus afterdischarges of spinal WDR neurons in rats with chronic nerve constriction.
Heterotopic inputs activate spinal wide dynamic range (WDR) neurons in rats with chronic constriction of one sciatic nerve (CCI rats). A possible contribution from these inputs, to long-lasting afterdischarges (ADs) of noxious evoked responses, was investigated during reversible input blockade from adjacent saphenous nerve and contralateral peripheral nerve territories. The results show significant AD reduction or suppression, indicating that heterotopic afferences contribute to mechanisms underlying prolonged ADs.
Sotgiu
Maria Luisa
ML
Istituto di Bioimmagini e Fisiologia Molecolare, Italy. maria.luisa.Sotgui@ibfm.cnr.it
Valente
Maurizio
M
Caramenti
Gian Carlo
GC
Biella
Gabriele Eliseo Mario
GE
D000200:Action Potentials / Q000502:physiology; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D002908:Chronic Disease; D003250:Constriction; D004195:Disease Models, Animal; D007839:Functional Laterality; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009407:Nerve Block / Q000379:methods; D009474:Neurons / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D010812:Physical Stimulation / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D020426:Sciatic Neuropathy / Q000473:pathology / Q000503:physiopathology*; D013116:Spinal Cord / Q000473:pathology*; D013997:Time Factors
D000779:Anesthetics, Local; D008012:Lidocaine