Simultaneous dynamic study of gastric emptying and changes of serum levels of gut hormones in patients after peptic ulcer surgery.
BACKGROUND
The aim was to examine the influence of different modalities of peptic ulcer surgery on the gastric emptying (GE) pattern and related serum level changes of selected gut hormones.


METHODS
Fifty eight subjects were examined. In 48 of them peptic ulcer surgery was performed at least six months before the examination: Billroth I (B1) in 11, Billroth II (B2) in 16, B1 with the selective vagotomy--Harkins 1 (H1) in 9 and B2 with the selective vagotomy--Harkins 2 (H2) in 12. Ten healthy volunteers (C) were also examined.


RESULTS
The results of gastric emptying showed that the lag phase duration was inversely related to the GE rates, and the GE pattern was linear in both controls (C) and in operated patients, except in B2 group, in which the GE pattern was exponential. In comparison with C group, GE was slower in B1, H1 and H2 groups, and faster in B2 group. The plasma gastrin values in C group, showing two peaks, were higher in relation to other groups. In relation to C group, higher values of motilin were obtained in patients after the selective vagotomy. The plasma somatostatin values recorded in B1 and H1 groups, showing the marked peaks, were higher in relation to C group. In relation to C group the highest plasma neurotensin values were obtained in B2 group.


CONCLUSIONS
In order to understand entirely the influence of peptic ulcer surgery on the GI function, further research of the role of specific hormones and neuropeptides is needed, which would enable more precise selection of the therapy in order to prevent postvagotomy and postgastrectomy syndromes.
Obradović
Vladimir B
VB
Institute for Nuclear Medicine, Clinical Centre of Serbia, Beograd, Serbia and Montenegro. vladimir.obradovic@kcs.ac.yu
Artiko
Vera
V
Stefanović
Branislav M
BM
Petrović
Milorad N
MN
Petrović
Nebojsa S
NS
D005746:Gastric Emptying; D005755:Gastrins / Q000737:chemistry; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D009496:Neurotensin / Q000097:blood / Q000737:chemistry; D010437:Peptic Ulcer / Q000601:surgery*; D011863:Radioimmunoassay; D013997:Time Factors; D014628:Vagotomy / Q000379:methods
D005755:Gastrins; D005768:Gastrointestinal Hormones; D009496:Neurotensin