title: Holdfast formation in motile swarmer cells optimizes surface attachment during Caulobacter crescentus development.
abstract: The adhesive holdfast is required for irreversible surface anchoring of Caulobacter crescentus cells. The holdfast is synthesized early during swarmer cell development and, together with pili and a functional flagellum, contributes to optimal attachment during cell differentiation. We present evidence that the timing of holdfast formation in swarmer cells is regulated posttranslationally and is dependent on the diguanylate cyclase PleD.
authors.affiliation: Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. urs.jenal@unibas.ch.
authors.forename: Assaf
authors.initials: A
authors.lastname: Levi
authors.forename: Urs
authors.initials: U
authors.lastname: Jenal
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology; D016935:Caulobacter crescentus / Q000166:cytology / Q000502:physiology*; D002453:Cell Cycle; D002462:Cell Membrane / Q000502:physiology; D029968:Escherichia coli Proteins; D019761:Phosphorus-Oxygen Lyases / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013499:Surface Properties
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase