Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
BACKGROUND
Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP).


METHODS
Diagnostic assessment of 263 pediatric BP probands included lifetime history of psychotic symptoms as well as longitudinal follow-up; family history of psychiatric illness was determined for 1st degree relatives.


RESULTS
Pediatric BP probands with lifetime history of psychosis had a higher percentage of positive family history of anxiety disorders and suicide attempts as compared to probands with no history of psychosis.


CONCLUSIONS
Familial loading for a spectrum of internalizing disorders is associated with presentation of psychotic symptoms in pediatric BP.
Rende
Richard
R
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. Richard_Rende@Brown.edu
Birmaher
Boris
B
Axelson
David
D
Strober
Michael
M
Gill
Mary Kay
MK
Valeri
Sylvia
S
Chiappetta
Laurel
L
Ryan
Neal
N
Leonard
Henrietta
H
Hunt
Jeffrey
J
Iyengar
Satish
S
Keller
Martin
M
D000293:Adolescent; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002648:Child; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007389:Internal-External Control; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology