title: Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.
abstract: The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology.
authors.affiliation: Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università degli studi di Palermo, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Carmela Rita
authors.initials: CR
authors.lastname: Balistreri
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Grimaldi
authors.forename: Florinda
authors.initials: F
authors.lastname: Listì
authors.forename: Sonya
authors.initials: S
authors.lastname: Vasto
authors.forename: Marco
authors.initials: M
authors.lastname: Caruso
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.forename: Enrico
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Colonna-Romano
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000208:Acute Disease / Q000453:epidemiology; D000369:Aged, 80 and over; D000483:Alleles; D003598:Cytoskeletal Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D008136:Longevity / Q000235:genetics*; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D000071198:Pyrin; D019713:Receptors, CCR5 / Q000235:genetics; D012802:Sicily / Q000453:epidemiology
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D019713:Receptors, CCR5