title: Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study.
abstract: OBJECTIVE
  This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD).
  
  
  METHODS
  Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method.
  
  
  RESULTS
  The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group.
  
  
  CONCLUSIONS
  These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
authors.affiliation: Department of Neuropsychiatry and Clinical Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Il Han
authors.initials: IH
authors.lastname: Choo
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.forename: Jong Choul
authors.initials: JC
authors.lastname: Youn
authors.forename: Dong Su
authors.initials: DS
authors.lastname: Lee
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Kang
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Kang
authors.forename: Jong In
authors.initials: JI
authors.lastname: Woo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005625:Frontal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18