title: Isoproterenol-induced elevated bispectral indexes while undergoing radiofrequency ablation: a case report.
abstract: The use of bispectral index (BIS) for monitoring neuronal function under general anesthesia has been expanding in practice. However, the meanings of the values are not always clear and have been shown to be altered by such drugs as ketamine, ephedrine, and physostigmine. Presented here is a case of increasing BIS in response to noradrenergic beta receptor stimulation via the administration of isoproterenol while under general anesthesia. The rise in BIS values appeared to have no correlation to the stimulation produced by the procedure. The patient reported no intraoperative recall despite BIS values in the high 70s. This case reinforces that BIS values require interpretation and can only be relevant to the circumstances of the individual case.
authors.affiliation: University of North Carolina Hospitals, Chapel Hill, NC, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Matthews
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D000768:Anesthesia, General; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D017115:Catheter Ablation; D016903:Drug Monitoring; D004554:Electric Countershock; D004562:Electrocardiography; D004569:Electroencephalography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage / Q000009:adverse effects*; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009474:Neurons / Q000187:drug effects; D012008:Recurrence; D013614:Tachycardia, Paroxysmal / Q000175:diagnosis / Q000601:surgery; D013617:Tachycardia, Supraventricular / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy
chemical_list: D000318:Adrenergic beta-Agonists; D002316:Cardiotonic Agents; D007545:Isoproterenol