Isolation and structure determination of anti-influenza component from Mahonia bealei.
The fraction possessing anti-influenza activity, which is obtained from the roots of Mahonia bealei (Fort), has been studied regarding its chemical compositions and molecular structure. The previous experiment on this fraction in vitro suggested that the anti-influenza effect was due to the existence of alkaloids in M. bealei (Fort), and mainly from one bisbenzylisoquinoline alkaloid. In this paper the structure of this bisbenzylisoquinoline alkaloid has been determined as 1R, 1'S-(+)-isotetrandrine by means of MS, 1H NMR, 13C NMR, FT-IR and HPLC analyses.
Zeng
Xiangying
X
State Key Lab of Organic Geochemistry, Guangdong Key Lab of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
Dong
Yulian
Y
Sheng
Guoying
G
Dong
Xichang
X
Sun
Xuehui
X
Fu
Jiamo
J
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044182:Benzylisoquinolines / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D028143:Mahonia / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D000470:Alkaloids; D000998:Antiviral Agents; D044182:Benzylisoquinolines; D010936:Plant Extracts