Topical voriconazole solution for cutaneous aspergillosis in a pediatric patient after bone marrow transplant.
Invasive aspergillosis seems to be on the rise, especially in immunocompromised children. Historically, only systemic amphotericin B has been effective against Aspergillus. Development of newer antifungal agents, such as voriconazole and caspofungin, has improved the treatment options available for aspergillosis, although no definitive management strategy has been established. Here we describe the use of topical voriconazole combined with systemic antifungal agents for cutaneous aspergillosis in a pediatric patient after bone marrow transplant.
Klein
Kristin C
KC
Clinical Sciences Division, University of Michigan College of Pharmacy and Health System, Ann Arbor, Michigan, USA. kriklein@umich.edu
Blackwood
R Alexander
RA
D000279:Administration, Cutaneous; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000601:surgery; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology / Q000601:surgery; D001231:Aspergillus flavus / Q000302:isolation & purification*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D003646:Debridement; D003881:Dermatomycoses / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology / Q000601:surgery; D004198:Disease Susceptibility; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D007279:Injections, Subcutaneous / Q000009:adverse effects; D009761:Nystatin / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011743:Pyrimidines / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin / Q000293:injuries; D014184:Transplantation, Homologous / Q000009:adverse effects; D014230:Triazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D009761:Nystatin; D000666:Amphotericin B; D065819:Voriconazole