Proteasomal oscillation during mild heat shock in aging human skin fibroblasts.
Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.
Kraft
David Christian
DC
Laboratory of Cellular Aging, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark.
Deocaris
Custer C
CC
Rattan
Suresh I S
SI
D000328:Adult; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000032:analysis / Q000378:metabolism*; D015595:Skin Aging; D013997:Time Factors
D046988:Proteasome Endopeptidase Complex