title: Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial.
abstract: OBJECTIVE
  To investigate the long-term effect of oral magnesium supplementation on clinical symptoms, bronchial reactivity, lung function and allergen-induced skin responses in children and adolescents with moderate persistent asthma.
  
  
  METHODS
  A double-blind randomized parallel placebo-controlled study.
  
  
  METHODS
  The patients were recruited from the Pediatric Outpatient Clinic, Division of Pulmonology, Allergy and Immunology, and followed at the Center for Investigation in Pediatrics at State University of Campinas Hospital, Brazil. Thirty-seven out of 72 patients met the study criteria. There were no dropouts.
  
  
  METHODS
  The 37 patients (aged 7-19 years, 19 males) were randomized in two groups: magnesium (n=18, 300 mg/day) and placebo (n=19), during 2 months. Both patient groups received inhaled fluticasone (250 microg twice a day) and salbutamol as needed. The primary outcome was bronchial reactivity evaluated with methacholine challenge test (PC20).
  
  
  RESULTS
  After a follow-up of 2 months, the methacholine PC20 for testing bronchial reactivity has augmented significantly in the magnesium group only. The skin responses to recognized antigens have also decreased in patients treated with magnesium. The forced vital capacity (FVC), the forced expiratory volume at first second (FEV1), the forced expiratory flow at 25-75 and the FEV1/FVC ratio were similar in both groups. The magnesium group presented fewer asthma exacerbations and used less salbutamol compared to the placebo group.
  
  
  CONCLUSIONS
  Oral magnesium supplementation helped to reduce bronchial reactivity to methacholine, to diminish their allergen-induced skin responses and to provide better symptom control in pediatric patients with moderate persistent asthma treated with inhaled fluticasone.
authors.affiliation: Department of Pediatrics and Center for Investigation in Pediatrics, State University of Campinas Medical School, Unicamp, Campinas, SP, Brazil. clesiogontijo@litoral.com.br
authors.forename: C
authors.initials: C
authors.lastname: Gontijo-Amaral
authors.forename: M A G O
authors.initials: MA
authors.lastname: Ribeiro
authors.forename: L S C
authors.initials: LS
authors.lastname: Gontijo
authors.forename: A
authors.initials: A
authors.lastname: Condino-Neto
authors.forename: J D
authors.initials: JD
authors.lastname: Ribeiro
mesh_terms: D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000627:therapeutic use; D000730:Androstadienes / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D001938:Brazil; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D019587:Dietary Supplements; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D000068298:Fluticasone; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome; D014797:Vital Capacity
chemical_list: D000730:Androstadienes; D001993:Bronchodilator Agents; D000068298:Fluticasone; D008274:Magnesium; D000420:Albuterol