Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology.
Candore
Giuseppina
G
Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università degli studi di Palermo, Italy.
Balistreri
Carmela Rita
CR
Grimaldi
Maria Paola
MP
Listì
Florinda
F
Vasto
Sonya
S
Caruso
Marco
M
Caimi
Gregorio
G
Hoffmann
Enrico
E
Colonna-Romano
Giuseppina
G
Lio
Domenico
D
Paolisso
Giuseppe
G
Franceschi
Claudio
C
Caruso
Calogero
C
D000208:Acute Disease / Q000453:epidemiology; D000369:Aged, 80 and over; D000483:Alleles; D003598:Cytoskeletal Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D008136:Longevity / Q000235:genetics*; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D000071198:Pyrin; D019713:Receptors, CCR5 / Q000235:genetics; D012802:Sicily / Q000453:epidemiology
D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D019713:Receptors, CCR5