title: Synthesis and anti-inflammatory activity of some selected aminothiophene analogs.
abstract: Some 2-aminothiophene analogs 1-6 were synthesized and characterized. Among the tested compounds, compound 1 (IC50 121.47 microM) exhibited highest while the compound 5 showed least anti-inflammatory potential (IC50 422 microM).
authors.affiliation: International Centerfor Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Zia
authors.initials: Z
authors.lastname: Ullah
authors.forename: Zia
authors.initials: Z
authors.lastname: Nullah
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Saima
authors.initials: S
authors.lastname: Jalil
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-Ur-Rahman
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013876:Thiophenes