title: Low compliance with colonoscopic screening in first-degree relatives of patients with large adenomas.
abstract: BACKGROUND
  Little is known about compliance with colonoscopy as a screening method in first-degree relatives of patients with large adenomas. Aims To evaluate the compliance with screening colonoscopy among this population, and its determinants.
  
  
  METHODS
  Data were obtained from the family part of the GEADE study, a study on genetic factors of colorectal adenomas. Index cases were 306 patients with adenomas > or = 10 mm. All living first-degree relatives aged 40-75 who could be contacted by the index case were asked to undergo a colonoscopy, unless they had had one in the previous 5 years.
  
  
  RESULTS
  Among 674 eligible relatives, 56 had had a colonoscopy within the preceding 5 years and 114 underwent a screening colonoscopy resulting in a compliance with screening colonoscopy of 18%. This was not related to most characteristics of index cases. Compliance was significantly lower when the index case lived in the Greater Paris area than when he/she lived in other areas (12% vs. 21%). It was higher in siblings (18%) and offspring (23%) than in parents (9%) and in relatives under 55 years old (22%) than in relatives aged 55 and over (15%).
  
  
  CONCLUSIONS
  Compliance with colonoscopy was low in first-degree relatives of patients with large adenomas. The reasons for this should be determined and appropriate strategies developed to increase compliance.
authors.affiliation: INSERM E 106, Faculté de Médecine, Dijon, France.
authors.forename: V
authors.initials: V
authors.lastname: Cottet
authors.forename: A
authors.initials: A
authors.lastname: Pariente
authors.forename: B
authors.initials: B
authors.lastname: Nalet
authors.forename: J
authors.initials: J
authors.lastname: Lafon
authors.forename: C
authors.initials: C
authors.lastname: Milan
authors.forename: S
authors.initials: S
authors.lastname: Olschwang
authors.forename: J
authors.initials: J
authors.lastname: Faivre
authors.forename: C
authors.initials: C
authors.lastname: Bonaiti-Pellié
authors.forename: C
authors.initials: C
authors.lastname: Bonithon-Kopp
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000235:genetics; D000328:Adult; D000368:Aged; D003113:Colonoscopy / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010375:Pedigree