title: Role of vascular endothelial growth factor in pulmonary endothelial cell injury by exercise challenge in asthmatic patients.
abstract: This study was designed to examine the role of vascular endothelial growth factor (VEGF) in pulmonary endothelial cell injury by exercise in asthmatics. Post-exercise circulating thrombomodulin (TM) levels were significantly increased in asthmatics. Moreover, the increase in TM levels with exercise was significantly correlated with VEGF level in induced sputum from asthmatics (r = 0.80, p = 0.0007). After inhaled steroid therapy, post-exercise TM levels were significantly decreased, but the increase in TM levels with exercise was also correlated with VEGF level (r = 0.60, p = 0.01). Thus, pulmonary endothelial cells stimulated by VEGF in asthmatic airways may be sensitive to exercise challenge.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Abenoku, Osaka, Japan. kanazawa-h@med.osaka-cu.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tochino
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Ichimaru
authors.forename: Toyoki
authors.initials: T
authors.lastname: Kodama
authors.forename: Shigenori
authors.initials: S
authors.lastname: Kyoh
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Umeda
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001250:Asthma, Exercise-Induced / Q000175:diagnosis* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001985:Bronchial Provocation Tests; D016022:Case-Control Studies; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011336:Probability; D012016:Reference Values; D012129:Respiratory Function Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013183:Sputum / Q000166:cytology; D018180:Thrombomodulin / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018180:Thrombomodulin; D042461:Vascular Endothelial Growth Factor A