title: Synthesis of tetrahydroxy perhydroaza-azulenes: tandem Johnson-Claisen rearrangement of D-glucose-derived allylic alcohols.
abstract: The Johnson-Claisen rearrangement of D-glucose-derived allylic alcohols 5a,b, afforded sugar-substituted gamma,delta-unsaturated ester in high yield. Conversion of the ester group to an azidomethyl group, epoxidation of the double bond and hydrogenation gave pyrrolidine ring skeletons 13a and 13b, which were transformed to tetrahydroxy perhydroaza-azulenes 1a and 1b, respectively. Glycosidase inhibitory activity was also evaluated.
authors.affiliation: Garware Research Centre, Department of Chemistry, University of Pune, India.
authors.forename: Shankar D
authors.initials: SD
authors.lastname: Markad
authors.forename: Narayan S
authors.initials: NS
authors.lastname: Karanjule
authors.forename: Tarun
authors.initials: T
authors.lastname: Sharma
authors.forename: Sushma G
authors.initials: SG
authors.lastname: Sabharwal
authors.forename: Vedavati G
authors.initials: VG
authors.lastname: Puranik
authors.forename: Dilip D
authors.initials: DD
authors.lastname: Dhavale