title: Hearing loss after discontinuing secondary prophylaxis for cryptococcal meningitis: relapse or immune reconstitution?
abstract: Relapse and immune reconstitution syndrome are difficult to distinguish in HIV-infected patients treated with antiretroviral therapy (ART). We report on a 26-year-old HIV-infected male (CDC C3) with hearing loss on the right side 2 months after discontinuing secondary prophylaxis for cryptococcal meningitis. CD4 cell counts had increased from 32/microl to stable counts > 200/microl for the preceding 6 months on ART but HIV replication was not fully suppressed (7,000 copies/ml). Magnetic resonance imaging identified lesions at the origin of the right cranial nerve VIII. Lumbar puncture revealed monocytic pleocytosis, slightly increased protein, but normal glucose and lactate levels, negative microbiological studies. Fluconazole was restarted and a new ART regimen was started in order to fully suppress HIV replication. Clinical and radiological signs were reversible during follow-up, and secondary prophylaxis was stopped after 6 months without adverse events. We review 26 published cases of cryptococcal infections with immune reconstitution syndrome and highlight the distinguishing features.
authors.affiliation: Infectious Diseases and Hospital Epidemiology, Dept. of Internal Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Khanna
authors.forename: R
authors.initials: R
authors.lastname: Nüesch
authors.forename: C
authors.initials: C
authors.lastname: Buitrago-Tellez
authors.forename: M
authors.initials: M
authors.lastname: Battegay
authors.forename: H H
authors.initials: HH
authors.lastname: Hirsch
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications*; D034381:Hearing Loss / Q000209:etiology*; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents