title: Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations.
abstract: SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.
authors.affiliation: Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan. nakamura@hama-med.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Chih-Ken
authors.initials: CK
authors.lastname: Chen
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: A
authors.initials: A
authors.lastname: Anitha
authors.forename: El-Wui
authors.initials: el-W
authors.lastname: Loh
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Atsuko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kawai
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Takebayashi
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Harano
authors.forename: Tokutaro
authors.initials: T
authors.lastname: Komiyama
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: David M
authors.initials: DM
authors.lastname: Ball
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Shih-Ku
authors.initials: SK
authors.lastname: Lin
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005091:Exons; D006239:Haplotypes; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008694:Methamphetamine / Q000506:poisoning*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D013624:Taiwan; D000099156:Superoxide Dismutase 2
chemical_list: D008694:Methamphetamine; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2