Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.
Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell-mediated allergic inflammation.
Ziegler
Steven F
SF
Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA.
Liu
Yong-Jun
YJ
D000818:Animals; D002465:Cell Movement; D017637:Clonal Deletion / Q000502:physiology; D016207:Cytokines / Q000737:chemistry / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology / Q000473:pathology; D019281:Dimerization; D004847:Epithelial Cells / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000473:pathology; D007136:Immunoglobulins; D007249:Inflammation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D053278:OX40 Ligand; D018121:Receptors, Cytokine / Q000502:physiology; D020395:Receptors, Interleukin-7 / Q000737:chemistry; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000378:metabolism; D048069:Tumor Necrosis Factors / Q000502:physiology; D000094632:Thymic Stromal Lymphopoietin
C498762:CRLF2 protein, human; D016207:Cytokines; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D053278:OX40 Ligand; D018121:Receptors, Cytokine; D020395:Receptors, Interleukin-7; C089251:TNFSF4 protein, human; C410591:Tslpr protein, mouse; D048069:Tumor Necrosis Factors; C415350:interleukin-7 receptor, alpha chain; D000094632:Thymic Stromal Lymphopoietin