[Advancement of PET and PET/CT in prostate carcinoma].
Functional imaging of prostate carcinoma was examined with the metabolic substrates 2-(18)F-fluorodeoxyglucose, (11)C-methionine, (18)F-fluorodihydrotestosterone, (11)C-acetate and (11)C/(18)F-choline. Based on upregulated enzymes of phospholipid metabolism in prostate carcinoma, (11)C/(18)F-choline is preferentially incorporated into phosphatidylcholine of membrane lipids of prostate cancer cells. PET allows sensitive detection of the (11)C/(18)F-choline signal and PET/CT fusion imaging enables intraprostatic signal localisation. Most published studies report a high detection rate of prostate carcinoma with (11)C/(18)F-choline PET/CT. Differentiation of prostate carcinoma from benign hyperplasia and from focal chronic prostatitis may be difficult; acute prostatitis accumulates (11)C/(18)F-choline with an intensity comparable to prostate carcinoma.
Reske
S N
SN
Abteilung Nuklearmedizin, Universität Ulm, Robert-Koch-Strasse 8, 89081, Ulm. sven.reske@uniklinik-ulm.de
Blumstein
N M
NM
Glatting
G
G
D002250:Carbon Radioisotopes; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes