title: HIV type 1 RNA level as a clinical indicator of renal pathology in HIV-infected patients.
abstract: To determine the value of human immunodeficiency virus type 1 (HIV-1) RNA level in distinguishing HIV-associated nephropathy from non-HIV-associated nephropathy renal pathological conditions, we retrospectively compared renal histopathological findings for 86 HIV-infected patients according to HIV-1 RNA levels. We found that HIV-associated nephropathy was unlikely among patients with HIV-1 RNA levels <400 copies/mL. Hypertensive vascular disease surpassed HIV-associated nephropathy as the most common renal pathological finding among the entire cohort. HIV-1 RNA level did not correlate with renal survival.
authors.affiliation: Department of Medicine, Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Estrella
authors.forename: Derek M
authors.initials: DM
authors.lastname: Fine
authors.forename: Joel E
authors.initials: JE
authors.lastname: Gallant
authors.forename: M Hafizur
authors.initials: MH
authors.lastname: Rahman
authors.forename: Nagapradeep
authors.initials: N
authors.lastname: Nagajothi
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Racusen
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scheel
authors.forename: Mohamed G
authors.initials: MG
authors.lastname: Atta
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D012367:RNA, Viral