Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.
CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
Kim
Kun-yong
KY
Department of Life Science, Research Center for Women's Diseases, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
Kim
Hwa Young
HY
Kim
Jae Hyeong
JH
Lee
Chul-Ho
CH
Kim
Do-Hyung
DH
Lee
Young Ho
YH
Han
Seung Hyun
SH
Lim
Jong-Seok
JS
Cho
Dae Ho
DH
Lee
Myeong-Sok
MS
Yoon
Sukjoon
S
Kim
Keun Il
KI
Yoon
Do-Young
DY
Yang
Young
Y
D054392:Adipokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009765:Obesity; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011924:Rats, Zucker; D016415:Sequence Alignment; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D054392:Adipokines; C512356:C1QTNF1 protein, human; C512355:C1qtnf1 protein, rat; C570300:CTRP1 protein, mouse; D018076:DNA, Complementary; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011506:Proteins; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha