[Effects of olbetam on lipid reroxidation, the antioxidant system and endogenous intoxication in patients with atherosclerosis obliterans of arteries of the lower extermities].
The interrelation was studied of processes of lipid peroxidation (LPO), the antioxidant system (AOS) with the level of endogenous intoxication (EI) during treatment with olbetam. Before the treatments administered, significantly high levels were recordable of LPO, EI against the background of low AOS activity. An one-month course of treatment with olbetam was found to be effective in all the parameters studied (LPO, AOS, EI). One month after the withdrawal of the drug the olbetam action on the AOS activity plasma level of MDA is still observable, with the processes of LPO and EI tending to return to normal. The abovestated permits recommending olbetam in the treatment of atherosclerosis obliterans of arteries of the inferior limbs as a hypolipidemic drug preparation endowed with an antioxidant and deintoxicationg activities.
Abdullakhodzhaeva
D G
DG
Zakhidova
D M
DM
Khashimova
Kh A
KhA
D000975:Antioxidants / Q000378:metabolism*; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007866:Leg / Q000098:blood supply*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000627:therapeutic use*; D016896:Treatment Outcome
D000975:Antioxidants; D000960:Hypolipidemic Agents; D011719:Pyrazines; C027696:acipimox