title: Prevention and treatment of skin aging.
abstract: Skin aging is a complex biological process that is a consequence of both intrinsic or genetically programmed aging that occurs with time, and extrinsic aging caused by environmental factors. The dramatic increase in the aging population and the psychosocial impact of skin aging has created a demand for effective interventions. The advances that have been made in the past 25 years in our understanding of the clinical, biochemical, and molecular changes associated with aging have led to the development of many different approaches to reduce, postpone, and in some cases, repair the untoward effects of intrinsic programmed aging and extrinsic environmental injury.
authors.affiliation: Department of Dermatology, University of California, Irvine, 92697-2400, USA. jlmccull@uci.edu
authors.forename: Jerry L
authors.initials: JL
authors.lastname: McCullough
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Kelly
mesh_terms: D000375:Aging; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D012176:Retinoids / Q000627:therapeutic use*; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D012879:Skin Physiological Phenomena; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D012176:Retinoids