title: Platelets and lipoprotein (a): a brief overview of their role in the pathogenesis of atherothrombosis.
abstract: The relationship between lipids and the haemostatic mechanisms participating in the evolution of the atherosclerotic plaque have been undergoing extensive investigation for over a century. Circulating lipoproteins can enhance platelet activity. Among these lipid fractions, lipoprotein (a) (Lp(a)), a predictor of atherosclerotic disease, has been proposed as a link between lipids and haemostasis. In this review, we briefly consider lipid-platelet, and particularly Lp(a)-platelet, interactions which may be relevant to the pathogenesis of atherosclerotic disease and its complications.
authors.affiliation: Department of Molecular Pathology and Clinical Biochemistry, Royal Free Hospital and School of Medicine (University of London), London, UK.
authors.forename: H J
authors.initials: HJ
authors.lastname: Milionis
authors.forename: D P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: A F
authors.initials: AF
authors.lastname: Winder