HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.
HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.
Tramontano
Enzo
E
Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella di Monserrato, 09142 Monserrato (Cagliari), Italy. tramon@unica.it
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D015497:HIV-1 / Q000201:enzymology* / Q000235:genetics; D019384:Nucleic Acid Synthesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D016914:Ribonuclease H / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D019380:Anti-HIV Agents; D019384:Nucleic Acid Synthesis Inhibitors; D016914:Ribonuclease H