Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis.
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.
Crivello
Antonio
A
Gruppo di Studio sull'Immunosenescenza, Sezione di Patologia Generale, Dipartimento di Biopatologia e Metadologie Biomediche, Università degli studi di Palermo, Italy.
Giacalone
Antonio
A
Scola
Letizia
L
Forte
Giusi Irma
GI
Nuzzo
Domenico
D
Giacconi
Robertina
R
Cipriano
Catia
C
Candore
Giuseppina
G
Mocchegiani
Eugenio
E
Colonna-Romano
Giuseppina
G
Lio
Domenico
D
Caruso
Calogero
C
D000368:Aged; D000369:Aged, 80 and over; D016893:Carotid Stenosis / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D017422:Sequence Analysis, DNA; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000235:genetics*; D053773:Transforming Growth Factor beta1
D021382:Protein Sorting Signals; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10