Deficit in schizophrenia to recruit the striatum in implicit learning: a functional magnetic resonance imaging investigation.
In schizophrenia, explicit learning deficits have been well established although it is less clear whether these patients have deficits in implicit learning (IL). IL is thought to depend on intact striatal functioning. This study examined the hypothesis that schizophrenia patients show deficient recruitment of striatal activation during an IL paradigm, relative to performance-matched healthy comparison subjects. Ten subjects with schizophrenia on atypical antipsychotic medication and 10 age, gender, education, and performance matched healthy comparison subjects underwent fMRI while performing an IL task. On the basis of whole-brain and striatal region-of-interest analyses, we found a relative lack of striatal activation in schizophrenia patients. This result is consistent with convergent evidence of striatal dysfunction in schizophrenia.
Reiss
Jeffrey P
JP
Psychiatric Neuroimaging Research Program, Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada. jpreiss@cc.umanitoba.ca
Campbell
Darren W
DW
Leslie
William D
WD
Paulus
Martin P
MP
Ryner
Lawrence N
LN
Polimeni
Joseph O
JO
Foot
Brendon J
BJ
Sareen
Jitender
J
D000328:Adult; D002421:Caudate Nucleus / Q000098:blood supply / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003342:Corpus Striatum / Q000098:blood supply / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000378:metabolism; D006179:Gyrus Cinguli / Q000098:blood supply; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012559:Schizophrenia / Q000503:physiopathology*; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000098:blood supply / Q000378:metabolism
D010100:Oxygen