Glass-glass ceramic thermoseeds for hyperthermic treatment of bone tumors.
Implantable thermoseeds are synthesised from mixtures of a melt-derived glass with composition SiO(2) (40)-CaO(40)-Fe(2)O(3)(20) (mol%) and a sol-gel glass with composition SiO(2)(58)-P(2)O(5)(6)-CaO(36) (mol%). Structural, textural and magnetic properties of the samples are evaluated. In vitro bioactivity is assessed in order to determine the potential capability to bond to living bone. In spite of the low textural properties of the material, a bioactive behavior is observed as a result of the sol-gel glass content. Although the crystallization of the glass ceramic provides the magnetic phase, the presence of sol-gel glass modifies the magnetic properties, improving the heating power. For the first time, hyperthermia heating experiments as well as preliminary biocompatibility assays have been carried out for this kind of material. The ability to reach hyperthermic temperature range together with the bioactive behavior makes this biomaterial a very promising candidate for bone cancer treatment.
Ruiz-Hernández
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E
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Serrano
M C
MC
Arcos
D
D
Vallet-Regí
M
M
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001859:Bone Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction; D044367:Phase Transition; D013696:Temperature; D014961:X-Ray Diffraction
D001672:Biocompatible Materials