title: Topical hydrocortisone and physiotherapy for nonretractile physiologic phimosis in infants.
abstract: The effect of hydrocortisone (HC), the steroid of lowest potency, and physiotherapy (PT) on non-retractile physiologic phimosis (PP) and the reduction of subsequent recurrent UTI was evaluated in male infants with UTI. Seventy-eight male infants with febrile UTI and nonretractile PP were prospectively randomized into HC (Plancol, n=39) and control (Vaseline, n=39) groups. Topical application of HC as a thin film around the preputial margin twice a day for four weeks with PT was instructed. The response rate in the HC group was 89.7% (35/39), which was significantly higher than the rate (20.5%; 8/39) in the control group (P<0.05). In the HC group, the response rate was much higher (96.1%) in the subgroup with PT than in the group without PT. Most of the response (88.5%) was observed within two weeks. During the following year, the recurrent rate of UTI was 7.1% (2/28) in the infants with retractile prepuces, which was significantly less than than the rate (29.6%; 8/27) in infants with nonretractile prepuces (P<0.05). In conclusion, topical HC and PT for 2-4 weeks proved to be a simple, safe and effective treatment for nonretractile PP in infants with UTI, and this procedure was beneficial in reducing recurrent UTI.
authors.affiliation: Department of Pediatrics, Seoul Municipal Dongbu Hospital, Seoul, South Korea.
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Cho
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Park
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D003131:Combined Modality Therapy; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010688:Phimosis / Q000150:complications / Q000628:therapy*; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D012008:Recurrence; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology
chemical_list: D006854:Hydrocortisone