Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding.
Ethidium bromide has been extended by fusing an additional aromatic ring resulting in a larger intercalator with increased affinity for poly r(A) x r(U), poly d(A) x d(T) and triple helices when compared to the parent heterocycle.
Tam
Victor K
VK
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
Liu
Qi
Q
Tor
Yitzhak
Y
D004996:Ethidium / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009696:Nucleic Acids / Q000737:chemistry*; D010777:Photochemistry; D044366:Transition Temperature
D007364:Intercalating Agents; D009696:Nucleic Acids; D004996:Ethidium