title: [Continuous glucose monitoring in high-risk subjects for developing type 2 diabetes].
abstract: OBJECTIVE
  To assess the relevance of unrecognised hyperglycaemia among high-risk subjects for developing type 2 diabetes.
  
  
  METHODS
  Cross-sectional multicentre study in primary care. Subjects aged 40 to 75 years with previous evidence of impaired glucose metabolism were screened according to the World Health Organization rules by means of an oral glucose tolerance test (OGTT). Those with diabetes diagnostic criteria were excluded. An individualized 48-h ambulatory continuous glucose monitoring (CGM) calibrated by plasma values (Glucoday) was performed. Data from biosensor activity were computerized in order to identify hyperglycaemic records.
  
  
  RESULTS
  50 out of 64 screened subjects were included and evaluated; there were 30 female (60%). Mean age was 59 years; body mass index, 30.9; HbA1c, 5.3%, and HOMA, 2.8. Regarding the CGM results, 9 whole registers (18%) were rejected because of technical problems and 41 continuous profiles (72%) were analysed, corresponding to 17 (41.5%) subjects with normal OGTT and 24 (58.5%) with non-diabetic hyperglycaemia on OGTT. Mean CGM time with hyperglycaemia (fasting > or = 6.1 mmol/l or non-fasting > or = 7.8 mmol/l) accounted for 5.8 h, a 17.2% of the effective register per subject (33.8 h). Both groups matched the World Health Organization diabetes diagnostic interval (fasting > or = 7 mmol/l or non-fasting > or = 11.1 mmol/l): 1.1 h of effective register (3.6%) and 1.2 h (3.3%), respectively.
  
  
  CONCLUSIONS
  The CGM evidenced a high degree of unrecognised hyperglycaemia among high-risk individuals. Therefore, casual plasma glucose measurements should be recommended to achieve early screening.
authors.affiliation: Unidad de Investigación en Diabetes y Metabolismo, Atención Primaria Reus-Tarragona, Institut Català de la Salut, Tarragona, Spain. costaber@gmail.com
authors.forename: Bernardo
authors.initials: B
authors.lastname: Costa
authors.forename: Jesús
authors.initials: J
authors.lastname: Vizcaíno
authors.forename: Joan Josep
authors.initials: JJ
authors.lastname: Cabré
authors.forename: Cruz María
authors.initials: CM
authors.lastname: Fuentes
authors.forename: Joan
authors.initials: J
authors.lastname: Boj
authors.forename: Josep Lluís
authors.initials: JL
authors.lastname: Piñol
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012307:Risk Factors
chemical_list: D001786:Blood Glucose