[Klotho gene and endothelial function].
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, skin atrophy). We have demonstrated that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in response to acetylcholine stimulation. Systemic nitric oxide production was also significantly reduced in klotho deficient mice. Oxidative stress was increased in klotho deficient mice. The klotho gene delivery improves multiple aging phenotypes. Our findings establish the basis for the therapeutic potential of klotho gene delivery in age-related diseases.
Saito
Yuichiro
Y
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine.
Kurabayashi
Masahiko
M
Nakamura
Tetsuya
T
Nagai
Ryozo
R
D000375:Aging / Q000235:genetics*; D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D005966:Glucuronidase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D000090265:Klotho Proteins; D051379:Mice; D008822:Mice, Transgenic; D009569:Nitric Oxide / Q000096:biosynthesis; D018384:Oxidative Stress; D010641:Phenotype
D009569:Nitric Oxide; D005966:Glucuronidase; D000090265:Klotho Proteins