[Analysis of the risk factors influencing the prognosis of orthotopic liver transplantation for hepatocellular carcinoma and summary of relevant clinical experience].
OBJECTIVE
To analyze the risk factors influencing the prognosis of orthotopic liver transplantation for hepatocellular carcinoma (HCC) and sum up the relevant clinical experience in diagnosis and treatment of HCC.


METHODS
The clinical data of 198 HCC patients, 177 males and 21 females, aged 49 (24-83), were analyzed.


RESULTS
The 0.5-, 1-, and 2-year survival rates were 89%, 78%, and 65 respectively. The rates of disease-free survival (DFS) were 85%, 73, and 67% respectively. Univariate analysis revealed that tumor size, presence of vascular invasion, Edmondson grade, TNM classification, and preoperative alpha-fetoprotein (AFP) were significantly related to DFS, and the 4 foregoing factors were also related to the survival rate. Cox regression analysis suggested that presence of vascular invasion was an independent prognostic factor of survival rate and DFS.


CONCLUSIONS
Vascular invasion plays a leading role in evaluating the prognosis of orthotopic liver transplantation for HCC. It is important to discover the micro-metastasis and explore more effective approaches to prevent recurrence after transplantation.
He
Yi-feng
YF
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Fan
Jia
J
Zhou
Jian
J
Wu
Zhi-quan
ZQ
Qiu
Shuang-jian
SJ
Huang
Xiao-wu
XW
Yu
Yao
Y
Sun
Jian
J
Xiao
Yong-sheng
YS
Yang
Guo-huan
GH
Song
Kang
K
Wang
Zheng
Z
Tang
Zhao-you
ZY
Wang
Yu-qi
YQ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins