RNA-mediated regulation of Bc1-2 and cyclin 'D' genes in human platelets.
The aim of this study was to understand the RNA-mediated regulation of genes coding for Bc1-2 and cyclin 'D'. Evidence was provided that these genes are regulated by receptor-C(k)-dependent signalling in human platelets. Further experiments to resolve the mechanism through which receptor-C(k) regulates these genes revealed that receptor-C(k)-dependent signalling is involved in the cleavage of a 125-kDa protein present in endoplasmic reticulum, resulting in generation of a 47-kDa factor that has affinity for a genomic sterol regulatory element as well as the platelet mRNA pool. Based upon these findings we propose a receptor-C(k) dependent signalling pathway for the regulation of Bc1-2 and cyclin 'D' genes at the post-transcriptional level.
Kaur
M
M
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Singh
J
J
Kaul
D
D