title: Chronic herpes simplex virus encephalitis in childhood.
abstract: Although herpes simplex virus is a major cause of acute encephalitis in childhood, chronic herpes simplex virus encephalitis has only rarely been reported. This report presents a case of chronic herpes simplex virus encephalitis in a 6-year-old female. Diagnosis was based on the detection of herpes simplex virus deoxyribonucleic acid by polymerase chain reaction in combination with the cerebrospinal fluid/serum ratio of herpes simplex virus-specific immunoglobulin G, the presence of herpes simplex virus-specific oligoclonal immunoglobulin G bands in cerebrospinal fluid, and calcifications in the temporal regions found on cerebral computed tomographic scan. Prolonged antiviral therapy was beneficial to later mental development.
authors.affiliation: Department of Pediatric Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
authors.forename: Wilhelmina G
authors.initials: WG
authors.lastname: Leen
authors.forename: Corry M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Verbeek
authors.forename: Michèl A
authors.initials: MA
authors.lastname: Willemsen
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Rotteveel
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018139:Simplexvirus / Q000235:genetics / Q000378:metabolism
chemical_list: D000998:Antiviral Agents