title: Genomic approach for the understanding of dynamic aspect of chromosome behavior.
abstract: Various functions are integrated into a single chromosome molecule. The genomic approach (ChIP-chip) we introduce here is a very powerful tool to study dynamic changes of the structure and function of the chromosome at the level of protein-DNA interaction as precisely as possible without prejudice or bias. This technology opens up the way to understand how local protein-protein or protein-DNA interactions lead to the dynamic changes of chromosome structure and how various chromosomal functions are connected to make a network for the faithful maintenance of the genome.
authors.affiliation: Laboratory of Genome Structure and Function, Division for Gene Research, Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama City, Kanagawa, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katou
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Kaneshiro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aburatani
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Shirahige
mesh_terms: D001483:Base Sequence; D002875:Chromosomes; D017931:DNA Primers; D004261:DNA Replication; D023281:Genomics; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D017931:DNA Primers