The angiogenetic effect of intramuscular administration of b-FGF and a-FGF on cardiac muscle: the influence of exercise on muscle angiogenesis.
Although angiogenetic therapy using recombinant growth factors holds much hope for the treatment of ischaemic diseases, there are still many unanswered questions, including the method of administration, the correct dose of these factors, and the duration of the therapeutic approach. Exercise has also been suggested to induce neovascularizaiton in muscles. We evaluated the angiogenetic effects of the intramuscular administration of basic-fibroblast growth factor (b-FGF) and acidic-fibroblast growth factor (a-FGF) in rat heart, compared with rats who exercised daily. In conclusion, both the intramuscular administration of b-FGF and exercise increased significantly angiogenesis in the heart in contrast to the intramuscular administration of a-FGF, which was ineffective.
Efthimiadou
Anna
A
Departments of Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. aefthim@med.duth.gr
Asimakopoulos
Byron
B
Nikolettos
Nikos
N
Giatromanolaki
Alexandra
A
Sivridis
Efthimios
E
Lialiaris
Theodoros S
TS
Papachristou
Dimitrios N
DN
Kontoleon
Eleni
E
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007273:Injections, Intramuscular; D008297:Male; D009206:Myocardium / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
D016222:Fibroblast Growth Factor 2; D016220:Fibroblast Growth Factor 1