title: [Nucleolysis in the herniated disk].
abstract: Back pain associated with a herniated disk has become an important and increasing general health problem in Germany and other industrialized countries. After all methods of conservative treatment have been exhausted, nucleolysis may be a minimally invasive alternative to surgery. In nucleolysis, chondrolytic substances or other substances, which reduce the pressure within the disk by other means, are injected into the nucleus pulposus under CT guidance. Among various substances, which have been employed for nucleolysis, an ozone-oxygen mixture appears to be very promising. The water-binding capacity of ozone results in a reduction of pain for several months. Moreover, it has an anti-inflammatory effect and results in an increase of perfusion. Ozone is converted into pure oxygen in the body and has a low allergic potential. Recent minimally invasive therapeutic methods such as percutaneous nucleotomy or laser treatment do not result in superior results compared with nucleolysis.
authors.affiliation: Institut für Diagnostische und interventionelle Radiologie, Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main. thomas.lehnert@kgu.de
authors.forename: T
authors.initials: T
authors.lastname: Lehnert
authors.forename: S
authors.initials: S
authors.lastname: Mundackatharappel
authors.forename: W
authors.initials: W
authors.lastname: Schwarz
authors.forename: S
authors.initials: S
authors.lastname: Bisdas
authors.forename: A
authors.initials: A
authors.lastname: Wetter
authors.forename: C
authors.initials: C
authors.lastname: Herzog
authors.forename: J O
authors.initials: JO
authors.lastname: Balzer
authors.forename: M G
authors.initials: MG
authors.lastname: Mack
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
mesh_terms: D001416:Back Pain / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D007404:Intervertebral Disc Chemolysis / Q000379:methods*; D007405:Intervertebral Disc Displacement / Q000150:complications* / Q000628:therapy*; D010126:Ozone / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome
chemical_list: D010126:Ozone