title: Event-related potential correlates of depression, insight and negative symptoms in males with recent-onset psychosis.
abstract: OBJECTIVE
  The neurobiology of clinical characteristics -in particular depression, insight and negative symptoms- in recent-onset psychosis (ROP) was studied using event-related potentials (ERPs).
  
  
  METHODS
  Twenty right-handed ROP men and 20 controls completed an auditory-oddball task. ROP men had minimum exposure to antipsychotic medication. N100, N200 and P300 were studied to ascertain the effects of (a) diagnosis (patients versus controls), and (b) clinical characteristics.
  
  
  RESULTS
  ROP men had significantly lower anterior N100, enhanced N200 at T3, and lower P300 at Pz than controls. Lower right-anterior N100 and enhanced right-anterior N200 amplitude explained 47.7% of negative symptoms. Left-central N100 amplitude explained 30.28% of negative symptoms. Lower left-posterior and higher right-posterior P300 amplitude explained 65.99% of total symptoms. Lower left-central N100, enhanced left-central N200 and depression explained 78.8% of impairments in insight and judgement. Impaired insight/judgement correlated positively with right-anterior N200 and was identified as the most significant co-efficient for depression.
  
  
  CONCLUSIONS
  Disturbed selective-attention and executive function indexed by N100 and N200, respectively, are associated with poor insight and negative symptoms. A complex interaction exists between insight and depression.
  
  
  CONCLUSIONS
  The current results demonstrate a biological basis of insight and depression and a complex interaction between the two, perhaps mediated by executive function, in early psychosis.
authors.affiliation: King's College London, Institute of Psychiatry, BIAU, Biostatistics and Computing, Centre for Neuroimaging Sciences, London SE5 8AF, UK. a.sumich@iop.kcl.ac.uk
authors.forename: Alex
authors.initials: A
authors.lastname: Sumich
authors.forename: Anthony
authors.initials: A
authors.lastname: Harris
authors.forename: Gary
authors.initials: G
authors.lastname: Flynn
authors.forename: Thomas
authors.initials: T
authors.lastname: Whitford
authors.forename: Nigel
authors.initials: N
authors.lastname: Tunstall
authors.forename: Veena
authors.initials: V
authors.lastname: Kumari
authors.forename: Michael
authors.initials: M
authors.lastname: Brammer
authors.forename: Evian
authors.initials: E
authors.lastname: Gordon
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Williams
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D003863:Depression / Q000209:etiology* / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology*