Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation.
The pathophysiology of diabetes includes oxidative stress and impaired heat shock protein (HSP) expression. We studied the effects of alpha-lipoic acid (LA) supplementation for 8 weeks and acute exercise on HSP60 expression and the oxidative stress marker 4-hydroxynonenal adducts (4-HNE) in streptozotocin-induced diabetic (SID) and nondiabetic control rats. Diabetes was associated with decreased HSP60 in the heart and increased levels of HSP60 and 4-HNE in the liver. LA increased HSP60 in the liver of control and diabetic rats and decreased 4-HNE in the liver and heart. Acute exercise increased liver 4-HNE, which was offset by LA. In conclusion, diabetes induced oxidative stress and impaired myocardial HSP60 expression, while LA partially offsets these alterations in a tissue-specific manner.
Oksala
Niku K J
NK
Department of Physiology, University of Kuopio, Finland.
Laaksonen
David E
DE
Lappalainen
Jani
J
Khanna
Savita
S
Nakao
Chitose
C
Hänninen
Osmo
O
Sen
Chandan K
CK
Atalay
Mustafa
M
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D018834:Chaperonin 60 / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000627:therapeutic use*
D000447:Aldehydes; D000975:Antioxidants; D018834:Chaperonin 60; D008063:Thioctic Acid; C027576:4-hydroxy-2-nonenal