Deciphering signaling control by phosphoproteome using mass spectrometry.
Analysis of changes in genes and protein profiles provides invaluable information to understand the activities and functions of proteins. However, their activities are further regulated by post-translational modifications, such as glycosylation and phosphorylation. Cell growth and apoptotic pathways are good examples of demonstrating the roles of phosphorylation in activation of protein cascades upon stimulation.
Leung
Yuet-Kin
YK
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. leungyk@ucmail.uc.edu
Ho
John W
JW
D017209:Apoptosis; D049109:Cell Proliferation; D013058:Mass Spectrometry; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry*; D020543:Proteome; D015398:Signal Transduction / Q000502:physiology*
D011506:Proteins; D020543:Proteome