Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation.
Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPARalpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPARalpha-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPARalpha dependence in the assay system. Surprisingly, a novel type of PPARalpha-independent peroxisome proliferation and enlargement was uncovered in PPARalpha-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11alpha, might be associated with the PPARalpha-independent peroxisome proliferation at least in part.
Zhang
Xiuguo
X
Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Tanaka
Naoki
N
Nakajima
Takero
T
Kamijo
Yuji
Y
Gonzalez
Frank J
FJ
Aoyama
Toshifumi
T
D042962:Acyl-CoA Oxidase / Q000378:metabolism; D000818:Animals; D011345:Fenofibrate / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D047493:PPAR alpha / Q000502:physiology*; D020025:Peroxisome Proliferators; D020675:Peroxisomes / Q000187:drug effects / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism
D000960:Hypolipidemic Agents; D008565:Membrane Proteins; D047493:PPAR alpha; D020025:Peroxisome Proliferators; C469727:Pex11alpha protein, mouse; D012333:RNA, Messenger; D042962:Acyl-CoA Oxidase; D011345:Fenofibrate