Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice.
In mice, a selective decontamination of the digestive tract regimen consisting of orogastric tobramycin, polymyxin E, and amphotericin B in combination with subcutaneous cefepime inhibited gram-negative bacilli, including Klebsiella pneumoniae, and did not promote vancomycin-resistant Enterococcus spp. (VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE.
Paterson
David L
DL
Division of Infectious Diseases, University of Pittsburg Medical Center, Pittsburg Pennslyvania, USA.
Stiefel
Usha
U
Donskey
Curtis J
CJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage* / Q000494:pharmacology; D003666:Decontamination / Q000379:methods*; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D007263:Infusions, Parenteral; D007422:Intestines / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D008826:Microbial Sensitivity Tests; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime