The role of nitric oxide in tumour progression.
Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.
Fukumura
Dai
D
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. dai@steele.mgh.harvard.edu
Kashiwagi
Satoshi
S
Jain
Rakesh K
RK
D000818:Animals; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase