[Kidney and hypertension].
The regulation of blood pressure is a complex process, involving several organs. The kidney plays a major role and is involved in the initiation and maintenance of hypertension. Mechanisms involved are: (1) the sympathetic nerveous system, (2) the renin-angiotensin system, (3) the regulation of sodium and water balance, (4) the production of vasoactive substances such as endothelin, adenosine or nitric oxide (NO), and (5) structural alterations such as a reduced number of glomeruli and nephrons. Several therapeutic intervention strategies affecting these mechanisms have already proven to be effective antihypertensive drugs.
Menne
Jan
J
Abteilung für Nephrologie, Medizinische Hochschule Hannover, Hannover.
Fliser
Danilo
D
Haller
Hermann
H
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000503:physiopathology; D009399:Nephrons / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D017673:Sodium Chloride, Dietary / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014882:Water-Electrolyte Balance
D000959:Antihypertensive Agents; D017673:Sodium Chloride, Dietary; D012964:Sodium