title: [Visualization of intimal proliferation of drug-eluting stent and bare mental stent by use of optical coherence tomography].
abstract: OBJECTIVE
  To compare neointimal proliferation of drug-eluting stent (DES) with bare mental stent (BMS) by optical coherence tomography (OCT).
  
  
  METHODS
  OCT images were obtained in 21 diseased coronary vessels with 23 stents in 19 patients with coronary artery disease at 5 - 93 months post DES or BMS stents. Twenty-two stents of all 23 stents were divided into three groups. Nine DES stents at 6 - 10 months post stenting were considered as group A, 8 BMS stents at 5 - 10 months post stenting as group B, and 5 BMS stents at 23 - 93 months post stenting as group C. OCT images were quantitatively analyzed to compare neointimal proliferation of three groups after stenting.
  
  
  RESULTS
  All 21 vessels and 23 stents OCT images were successfully acquired. The maximal neointima, luminal loss in diameter and cross sectional area (CSA), and restenosis in diameter and CSA were significantly statistically different within three groups. The maximal intimal proliferations post stenting in group A were significantly lower than group B (0.20 mm +/- 0.13 mm vs 0.81 mm +/- 0.46 mm, P = 0.019) or group C (0.91 mm +/- 0.27 mm, P = 0.007), luminal loss of diameter in group A were significantly lower than group B (0.27 mm +/- 0.17 mm vs 1.12 mm +/- 0.79 mm, P = 0.009) or group C (1.20 mm +/- 0.31 mm, P = 0.013), restenosis rates in diameter in group A were significantly less than group B (8.90% +/- 4.47% vs 36.36% +/- 24.34%, P = 0.009) or group C (35.48 +/- 6.09, P = 0.017), luminal loss in CSA in group A were lower than group B (1.14 mm(2) +/- 0.9 mm(2) vs 3.96 mm(2) +/- 2.62 mm(2), P = 0.009) or group C (4.66 mm(2) +/- 1.66 mm(2), P = 0.006), and restenosis rates in CSA in group A were less than group B (15.43% +/- 7.89% vs 48.14% +/- 30.43%, P = 0.017) or group C (55.20% +/- 11.24%, P = 0.009). Almost all surfaces of 13 BMS stent struts were covered by significant neointimal coverage, surfaces of 10 DES struts were less significantly neointimal coverage, and some surfaces of DES struts were uncovered with neointima even at 29 months post stenting.
  
  
  CONCLUSIONS
  OCT imaging can clearly visualize stent struts and neointimal formation of strut surfaces post DES or BMS stenting, and this new imaging modality will play important role in evaluating the efficacy of drug-eluting stent.
authors.affiliation: Department of Cardiology, Beijing Electric Power Hospital, Beijing 100073, China.
authors.forename: Bu-xing
authors.initials: BX
authors.lastname: Chen
authors.forename: Feng-yun
authors.initials: FY
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Xie
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Sun
authors.forename: Xu-mei
authors.initials: XM
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Xi-zhe
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Chu
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000473:pathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D015607:Stents; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology*
chemical_list: D008670:Metals