CSF-studies in neuropsychiatric disorders.
Cerebrospinal fluid (CSF) is a clear and colourless fluid that surrounds the brain and spine. Due to the close proximity of CSF to the brain, pathological brain-processes are likely to be reflected in CSF. CSF can be obtained through lumbar puncture and is frequently performed in the differential diagnosis of neuropsychiatric disorders. Beyond clinical applications, CSF has been studied as part of different research-protocols. In this review, we will focus on CSF-analysis in Alzheimer Disease, major depression and schizophrenia. We will review both clinical applications as well as research applications in all three disorders. We will also assess new technological advances that have made it possible to study large numbers of proteins in CSF and how these advances may change CSF-analysis in the years to come.
Raedler
Thomas J
TJ
University Hospital Hamburg-Eppendorf, Department of Psychiatry, Martinistr. 52, 20246 Hamburg, Germany. traedler@uke.uni-hamburg.de
Wiedemann
Klaus
K
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000737:chemistry; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid; D040901:Proteomics; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D018377:Neurotransmitter Agents; D016875:tau Proteins