title: [RNA interference: biology and perspectives of application in biomedicine and biotechnology].
abstract: RNA interference (RNAi) is among the most particular mechanisms of gene expression regulation. Besides, small interfering RNAs are significant players in cell defence either from viral infection or retrotransposons. Medical utilization of RNAi gives a handful of ways to cure viral and oncological illnesses. RNA interference, also, represents a useful tool for research, because it allows quick production of monogene functional knockouts. In this review we describe the most recent conceptions about RNAi mechanisms and actual approaches for it's usage.
authors.forename: A E
authors.initials: AE
authors.lastname: Vil'gel'm
authors.forename: S P
authors.initials: SP
authors.lastname: Chumakov
authors.forename: V S
authors.initials: VS
authors.lastname: Prasolov
mesh_terms: D000818:Animals; D001709:Biotechnology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*; D014777:Virus Diseases / Q000235:genetics* / Q000628:therapy
chemical_list: D034741:RNA, Small Interfering; D018626:Retroelements