title: WRN's tenth anniversary.
abstract: Werner syndrome (WS) is a segmental progeroid syndrome in which patients display pleiotropic features of aging seen in the normal population. The advent of positional cloning in the 1990s markedly accelerated the identification of human disease-causing genes. In 1996, mutations in WRN, which was shown to encode a new, putative member of the family of RecQ DNA helicases, were identified in four patients as the cause of WS. Ten years after the identification of WRN, what have we learned about its role in WS, and its contribution to normal aging?
authors.affiliation: Department of Neurology, Yale University, New Haven, CT 06520, USA. fuki.hisama@yale.edu
authors.forename: Fuki M
authors.initials: FM
authors.lastname: Hisama
authors.forename: Vilhelm A
authors.initials: VA
authors.lastname: Bohr
authors.forename: Junko
authors.initials: J
authors.lastname: Oshima
mesh_terms: D000328:Adult; D005808:Genes, Recessive; D006801:Humans; D008875:Middle Aged; D014898:Werner Syndrome / Q000235:genetics* / Q000503:physiopathology