title: Successful liver transplantation following medical management of portopulmonary hypertension: a single-center series.
abstract: Severe portopulmonary hypertension (POPH) is an absolute contraindication to orthotopic liver transplantation (OLT). Vasodilators have been used, but the safety of subsequent transplantation and the reversibility of pulmonary hypertension after transplantation are uncertain. This study examined the feasibility and post-transplant effects of liver transplantation following medical control of POPH. Eight consecutive patients (three females and five males, ages 39-51) with POPH as their only contraindication to transplantation were treated with continuous intravenous epoprostenol. Liver transplantation was considered if the mean pulmonary artery pressure (PAM) was lowered to <35 mmHg. Epoprostenol 2-8 ng/kg/min successfully improved hemodynamics in seven of eight patients, usually within 6.5 months of initiating therapy. PAM declined from an average of 43-33 mmHg (p=0.03); mean pulmonary vascular resistance declined from 410 to 192 dyn s cm-5 (p=0.01) and cardiac output increased from 6.6 to 10 L/min (p=0.02). Six of the seven responders were actively listed for liver transplantation. Two died on the waiting list; the remaining four were transplanted and remain alive and well 9-18 months post-OLT-two without vasodilators, and two on oral medication. We conclude that pulmonary vasodilators permit safe liver transplantation in some cases, and that POPH may be reversible after transplantation.
authors.affiliation: Department of Medicine, Surgery, Baylor College of Medicine, Houston, Texas, USA. normans@bcm.edu
authors.forename: N
authors.initials: N
authors.lastname: Sussman
authors.forename: V
authors.initials: V
authors.lastname: Kaza
authors.forename: N
authors.initials: N
authors.lastname: Barshes
authors.forename: R
authors.initials: R
authors.lastname: Stribling
authors.forename: J
authors.initials: J
authors.lastname: Goss
authors.forename: C
authors.initials: C
authors.lastname: O'Mahony
authors.forename: E
authors.initials: E
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Vierling
authors.forename: A
authors.initials: A
authors.lastname: Frost
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D011464:Epoprostenol / Q000627:therapeutic use*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000601:surgery; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000601:surgery; D007262:Infusions, Intravenous; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D011464:Epoprostenol