Finite element modeling of a microparticle manipulator.
The contactless movement of microparticles and cells to known locations within a fluid volume is of interest in the fields of microtechnology and life sciences. A device which can position such inhomogeneities suspended in a fluid at multiple locations is described and modeled. The device consists of a thin fluid layer contained in a channel etched into a silicon wafer. Waves are excited by a macro-piezoelectric plate with electrodes on the top and bottom surfaces and, as a result, waves propagate into the adjacent fluid. The result is a pressure field throughout the fluidic volume. When an inhomogeneity in a fluid is exposed to an ultrasonic field the acoustic radiation force results; this is found by integrating the pressure over the surface of the particle, retaining second order terms, and taking the time average. Thus, due to the presence of a pressure field in the fluid in which the particles are suspended, a force field is created. The particles are then collected at the locations of the force potential minima. In the device described here, the force field is used to position particles into lines. The locations of the particles are predicted by using a finite element model of the system. The experimental and modeling results, presented here, are in good agreement.
Neild
Adrian
A
Center of Mechanics, ETH Zurich, 8092 Zurich, Switzerland. adrian.neild@imes.mavt.ethz.ch <adrian.neild@imes.mavt.ethz.ch>
Oberti
Stefano
S
Haake
Albrecht
A
Dual
Jürg
J
D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020342:Finite Element Analysis; D044085:Microfluidics / Q000295:instrumentation*; D008846:Micromanipulation / Q000295:instrumentation* / Q000379:methods; D008863:Microspheres; D008954:Models, Biological; D010316:Particle Size; D011312:Pressure; D013314:Stress, Mechanical; D014159:Transducers; D014465:Ultrasonics; D014867:Water / Q000737:chemistry*
D014867:Water