title: Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract.
abstract: Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type 1 knockout (IL-1R(1) KO) and normal wild type mice were intranasally infected with M. kansasii. IL-1R(1) KO mice demonstrated a reduced antibacterial response in the lungs and an increased dissemination to the liver, which was accompanied by an enhanced pulmonary inflammatory response. These data identify IL-1 as an important component of the innate immune response to lung infection by M. kansasii.
authors.affiliation: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands. c.wieland@amc.uva.nl
authors.forename: Catharina W
authors.initials: CW
authors.lastname: Wieland
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: Jennie M
authors.initials: JM
authors.lastname: Pater
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Weijer
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008168:Lung / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology* / Q000382:microbiology; D019909:Mycobacterium kansasii / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology*; D053573:Receptors, Interleukin-1 Type I / Q000172:deficiency / Q000235:genetics / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D053573:Receptors, Interleukin-1 Type I