title: Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
abstract: OBJECTIVE
  To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
  
  
  METHODS
  A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy.
  
  
  RESULTS
  Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients.
  
  
  CONCLUSIONS
  The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.
authors.affiliation: Post Graduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu (J&K) India 180001.
authors.forename: Sapna
authors.initials: S
authors.lastname: Gupta
authors.forename: V R
authors.initials: VR
authors.lastname: Tandon
authors.forename: B
authors.initials: B
authors.lastname: Kapoor
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: G D
authors.initials: GD
authors.lastname: Gupta
authors.forename: V
authors.initials: V
authors.lastname: Khajuria
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D013629:Tamoxifen / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D020845:Selective Estrogen Receptor Modulators; D014280:Triglycerides; D013629:Tamoxifen