Tibolone and estradiol plus norethisterone acetate similarly influence endothelium-dependent vasodilatation in healthy postmenopausal women.
In healthy postmenopausal women, E(2) plus norethisterone acetate (1 mg + 0.5 mg) or tibolone (2.5 mg) similarly modify flow-mediated endothelium-dependent vasodilatation. The effect is dependent on baseline vasodilator reserve, with low values being augmented by either treatment.
Cagnacci
Angelo
A
Department of Obstetrics, Gynecology and Pediatrics, University Hospital of Modena, Modena, Italy. cagnacci@unimore.it
Renzi
Antonietta
A
Cannoletta
Marianna
M
Pirillo
Debora
D
Arangino
Serenella
S
Volpe
Annibale
A
D001916:Brachial Artery / Q000502:physiology; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D009652:Norpregnenes / Q000494:pharmacology*; D017698:Postmenopause; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology*
D004338:Drug Combinations; D009652:Norpregnenes; D004958:Estradiol; D000077563:Norethindrone Acetate; C027385:tibolone; D009640:Norethindrone