title: Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats.
abstract: The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose subcutaneous (SC) administration of 2mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography and the data obtained were subjected to non-compartmental kinetic analysis. Marbofloxacin peak plasma concentration (C(max)=1.77+/-0.24microg/mL) was reached 1.25+/-0.50h (T(max)) after SC administration. The elimination half-life (t(1/2beta)) and area under curve (AUC) were 5.74+/-1.21h and 8.15 vs 2.33microg h/mL, respectively. Taking into account the values obtained for the efficacy indices, it was concluded that a SC dose of 2mg/kg/24h of marbofloxacin could be adequate to treat infections caused by high susceptible bacteria like Escherichia coli or Salmonella spp.
authors.affiliation: Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina.
authors.forename: Samanta Waxman
authors.initials: SW
authors.lastname: Dova
authors.forename: M Dolores
authors.initials: MD
authors.lastname: San Andrés
authors.forename: Fernando
authors.initials: F
authors.lastname: González
authors.forename: Manuel I
authors.initials: MI
authors.lastname: San Andrés
authors.forename: José J
authors.initials: JJ
authors.lastname: De Lucas
authors.forename: Casilda
authors.initials: C
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006041:Goats / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007279:Injections, Subcutaneous / Q000662:veterinary; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin