title: Cytokines and chemokines orchestrate atopic skin inflammation.
abstract: Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
authors.affiliation: Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany. Bernhard.Homey@uni-duesseldorf.de
authors.forename: Bernhard
authors.initials: B
authors.lastname: Homey
authors.forename: Martin
authors.initials: M
authors.lastname: Steinhoff
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruzicka
authors.forename: Donald Y M
authors.initials: DY
authors.lastname: Leung
mesh_terms: D002465:Cell Movement; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D012867:Skin / Q000276:immunology
chemical_list: D018925:Chemokines; D016207:Cytokines