title: HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?
abstract: HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
authors.affiliation: Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, ElManar University, Tunis, 1060, Tunisia. amal.baccar@laposte.net
authors.forename: Amal
authors.initials: A
authors.lastname: Baccar Harrath
authors.forename: Besma
authors.initials: B
authors.lastname: Yacoubi Loueslati
authors.forename: Wafa
authors.initials: W
authors.lastname: Troudi
authors.forename: Slama
authors.initials: S
authors.lastname: Hmida
authors.forename: Syrine
authors.initials: S
authors.lastname: Sedkaoui
authors.forename: Amel
authors.initials: A
authors.lastname: Dridi
authors.forename: Afef
authors.initials: A
authors.lastname: Jridi
authors.forename: Farhat
authors.initials: F
authors.lastname: Ben Ayed
authors.forename: Khaled
authors.initials: K
authors.lastname: Ben Rhomdhane
authors.forename: Amel
authors.initials: A
authors.lastname: Ben Ammar Elgaaied
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control; D016022:Case-Control Studies; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D015994:Incidence; D015810:Linkage Disequilibrium / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II