Structure of the DNA of the adenovirus 7-simian virus 40 hybrid, e46, by electron microscopy.
The DNA molecule of the adenovirus 7-simian virus (SV) 40 hybrid, E46(+), contains a single substitution of SV40 DNA located about 0.05 adenovirus 7 lengths from one end (arbitrarily designated the left end). The left to right direction in the SV40 DNA segment of the hybrid corresponds to the clockwise direction in the SV40 physical map. The left end point of the segment maps at about SV40 map position 0.50 +/- 0.01 and the right end point at about SV40 map position 0.66 +/- 0.01. The region between SV40 map positions 0.71 and 0.11 (clockwise) is deleted. Thus, the region between SV40 map position 0.50 and 0.66 (clockwise) is repeated in tandem.
Kelly
T J
TJ
Department of Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.