title: Effect of physical training on insulin resistance in patients with chronic heart failure.
abstract: BACKGROUND
  The effect of physical training on insulin resistance (IR) in chronic heart failure (CHF) remains unclear.
  
  
  RESULTS
  Fourteen patients with CHF performed physical training using a bicycle ergometer; 9 patients (64%) were hyperinsulinemic and insulin resistant (HOMA IR > 1.97). Exercise tolerance increased (5.1 +/- 1.7 to 6.9 +/- 2.7 METs, p < 0.05) and heart rate at rest decreased (82 +/- 15 to 72 +/- 6, p < 0.05) in the IR group after physical training. Physical training also decreased the insulin level (15.1 +/- 5.6 to 9.8 +/- 2.6 microU/ml, p < 0.05) and HOMA IR (3.7 +/- 1.4 to 2.3 +/- 0.6, p < 0.05) in the IR group, but not in the 5 patients (36%) without IR or in 6 control patients.
  
  
  CONCLUSIONS
  Physical training can improve hyperinsulinemia and IR in patients with CHF.
authors.affiliation: Division of Cardiology, Kurume University Medical Center, Kurume, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Motooki
authors.initials: M
authors.lastname: Minohara
authors.forename: Masatugu
authors.initials: M
authors.lastname: Ohe
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Katoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Gensyo
authors.initials: G
authors.lastname: Iwami
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015444:Exercise; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin