Metoclopramide aborts cough-induced headache and ameliorates cough--a pilot study.
Metoclopramide (MTCL) can abort attacks of migraine headache. I report swift resolution of cough-induced headache as well as suppression of cough in six male patients following parenteral administration of MTCL. A similar unexpected rapid antitussive action of MTCL was also observed in 12 of 14 other patients (13 male and 1 female) with severe paroxysmal cough without headache. Use of MTCL primarily for analgesia is reviewed, and the pharmacological basis for its antinociceptive action is proposed. As a nonopiate agent with potential to stimulate endogenous opiate-mediated mechanisms, MTCL appears to have additional valuable roles in clinical practice. This is the first report of an antitussive action of MTCL. Further controlled studies are required to confirm the therapeutic role of MTCL in cough-induced headache as well as its potential antitussive and general analgesic actions.
Gupta
V K
VK
Dubai Police Medical Services, Dubai, United Arab Emirates. dr_vkgupta@yahoo.com
D000328:Adult; D000368:Aged; D000996:Antitussive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003371:Cough / Q000188:drug therapy*; D005260:Female; D051270:Headache Disorders, Primary / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome
D000996:Antitussive Agents; D008787:Metoclopramide