Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis.
A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 microM and also showed antibacterial activity against Escherichia coli and S. aureus.
Yoo
Jung-Sung
JS
Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-600, Republic of Korea.
Zheng
Chang-Ji
CJ
Lee
Sangku
S
Kwak
Jin-Hwan
JH
Kim
Won-Gon
WG
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry* / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D011480:Protease Inhibitors; C514079:macrolactin N; D000581:Amidohydrolases; C084507:peptide deformylase