Small molecule inhibitors of IgE synthesis.
A novel series of small molecule inhibitors of IgE synthesis are described. Compounds were optimized for potency, metabolic stability and absence of genetic toxicology.
Brown
Alan
A
Discovery Chemistry, Pfizer Global Research and Development, Sandwich, UK. Alan.D.Brown@pfizer.com
Henderson
Alan
A
Lane
Charlotte
C
Lansdell
Mark
M
Maw
Graham
G
Monaghan
Sandy
S
D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D020128:Inhibitory Concentration 50; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D015394:Molecular Structure; D008970:Molecular Weight; D009930:Organic Chemicals / Q000737:chemistry* / Q000494:pharmacology*
D009930:Organic Chemicals; D007073:Immunoglobulin E; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2