title: Sex- and age-related differences in rabies immunoglobulin hypersensitivity.
abstract: We retrospectively reviewed 72132 patients who had received rabies immunoglobulin between 1987 and 2005 at the Queen Saovabha Memorial Institute, Bangkok. Purified equine rabies immunoglobulin (ERIG) was given to 42965 (59.56%) patients and human rabies immunoglobulin (HRIG) to 29167 (40.44%) patients. A total of 812 patients from both groups (1.13%) reported adverse reactions; among those who had received ERIG, 43.13% were male and 56.87% were female, and among those who had received HRIG, 34.62% were male and 65.38% were female. Females were at higher risk of exhibiting ERIG or HRIG hypersensitivity than males (P<0.01). None of the reactions was life-threatening. Serum sickness-like reactions to ERIG and HRIG were rare under the age of 10 years (0.05 and 0.01% among recipients in that age group).
authors.affiliation: WHO Collaborating Centre for Rabies and Venomous Snake Research, Queen Saovabha Memorial Institute, Thai Red Cross Society, 1871 Rama IV Road, Bangkok 10330, Thailand. sukanitta@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Suwansrinon
authors.forename: W
authors.initials: W
authors.lastname: Jaijareonsup
authors.forename: H
authors.initials: H
authors.lastname: Wilde
authors.forename: M
authors.initials: M
authors.lastname: Benjavongkulchai
authors.forename: C
authors.initials: C
authors.lastname: Sriaroon
authors.forename: V
authors.initials: V
authors.lastname: Sitprija
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011819:Rabies Vaccines / Q000009:adverse effects*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D011819:Rabies Vaccines