Office-based intralesional cidofovir injections for nasal septal papilloma: a pilot study.
OBJECTIVE
To determine if nasal septal papilloma is responsive to intralesional cidofovir injections.


METHODS
Five adult males, ages 37 to 57, presented with nasal septal or columellar papilloma. Three lesions had been previously excised with the laser and recurred. The lesions were injected with cidofovir on a monthly basis until complete resolution or any residual lesion was excised afterwards with the laser.


RESULTS
All patients achieved disease remission sustained over 10 to 24 months. Overall doses were much lower than those described for laryngeal papillomatosis and no toxic effects were observed.


CONCLUSIONS
Office-based intralesional injections of cidofovir may show benefit in the treatment of nasal septal papilloma.


METHODS
C-4.
Shemen
Larry J
LJ
Department of Otolaryngology, New York University School of Medicine, 233 East 69th Street, New York, NY 10021, USA. larrys@firstgate.net
Shnayder
Yelizaveta
Y
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000188:drug therapy*; D063065:Organophosphonates / Q000008:administration & dosage*; D010045:Outpatients; D010212:Papilloma / Q000188:drug therapy*
D000970:Antineoplastic Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir