Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum.
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg x d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).
Li
Yan-Qun
YQ
College of Life Science, South China Normal University, Guangzhou 510631, PR China. liyq9168@hotmail.com
Wang
Shun-Fa
SF
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured / Q000821:virology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli / Q000737:chemistry; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects*; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000382:microbiology / Q000517:prevention & control*; D006538:Heptanoic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D023421:Models, Animal; D009163:Mycobacterium bovis; D020940:Reishi / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006538:Heptanoic Acids; D008070:Lipopolysaccharides