Use of ticlopidine and cilostazol after intracoronary drug-eluting stent placement in a patient with previous clopidogrel-induced thrombotic thrombocytopenic purpura: a case report.
Thrombotic thrombocytopenic purpura (TTP) is an extremely rare but potentially fatal adverse reaction to the thienopyridines, clopidogrel and ticlopidine. We report the case of a patient with a history of clopidogrel-induced TTP who subsequently was successfully treated with aspirin, ticlopidine and cilostazol after stenting for severe, symptomatic coronary artery disease. This case supports the theory that clopidogrel and ticlopidine mediate TTP through slightly different mechanisms and that ticlopidine may be safely used in this setting if absolutely necessary. Moreover, while sufficient data are lacking, the combination of aspirin and cilostazol in this setting may provide adequate antithrombotic protection long term after drug-eluting stent placement.
Patel
Taral N
TN
Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Kreindel
Mark
M
Lincoff
A Michael
AM
D051722:ADAM Proteins / Q000502:physiology; D000071097:ADAMTS1 Protein; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D001241:Aspirin / Q000627:therapeutic use; D001323:Autoantibodies / Q000502:physiology; D000077407:Cilostazol; D000077144:Clopidogrel; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000628:therapy; D003328:Coronary Thrombosis / Q000517:prevention & control; D004359:Drug Therapy, Combination; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D010956:Plasmapheresis; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D015607:Stents; D013777:Tetrazoles / Q000008:administration & dosage*; D013988:Ticlopidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*
D001323:Autoantibodies; D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000077144:Clopidogrel; D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; D000077407:Cilostazol; D013988:Ticlopidine; D001241:Aspirin