title: Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients.
abstract: We analyzed 3,475 human immunodeficiency virus sequences and 241 therapeutic histories. The L74I mutation was carried by 7% of viruses. L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations. It seemed to be linked to the use of abacavir or efavirenz.
authors.affiliation: Department of Virology, Pitié-Salpêtrière Hospital, 75013 Paris, France. marc.wirden@psl.aphp.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Roquebert
authors.forename: Anne
authors.initials: A
authors.lastname: Derache
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Claudine
authors.initials: C
authors.lastname: Duvivier
authors.forename: Jade
authors.initials: J
authors.lastname: Ghosn
authors.forename: Stephanie
authors.initials: S
authors.lastname: Dominguez
authors.forename: Véronique
authors.initials: V
authors.lastname: Boutonnet
authors.forename: Zaina
authors.initials: Z
authors.lastname: Ait-Arkoub
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Genevieve
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D048588:Benzoxazines; D003521:Cyclopropanes; D015224:Dideoxynucleosides / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D009154:Mutation; D010078:Oxazines / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D000099227:Abacavir
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D015224:Dideoxynucleosides; D054303:HIV Reverse Transcriptase; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir; C098320:efavirenz