Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis.
Vascular adhesion protein-1 (VAP-1) is an endothelial cell molecule which controls leukocyte infiltration into tissues. Elevated serum soluble VAP-1-levels have been described in certain diseases with an inflammatory component. VAP-1 expression or function has not previously been studied in multiple sclerosis (MS). We report here that the concentration of soluble VAP-1 in serum is significantly higher in multiple sclerosis patients with ongoing inflammatory activity, as demonstrated by gadolinium-enhancing MRI lesions, when compared to patients with no gadolinium-enhancing lesions (555+/-195 vs. 388+/-102 ng/ml, p=0.0068). We propose that VAP-1 might participate in controlling leukocyte entry into inflamed brain.
Airas
Laura
L
Department of Neurology and MediCity Research Laboratory, University of Turku, PO Box 52, 20521Turku, Finland. laura.airas@utu.fi
Mikkola
Jari
J
Vainio
Jani M
JM
Elovaara
Irina
I
Smith
David J
DJ
D000328:Adult; D000368:Aged; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood* / Q000276:immunology*; D001812:Blood-Brain Barrier / Q000503:physiopathology; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology; D005260:Female; D005682:Gadolinium; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D011237:Predictive Value of Tests; D015854:Up-Regulation / Q000276:immunology
D015815:Cell Adhesion Molecules; D005682:Gadolinium; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)