title: Noninvasive assessment of pulmonary emphysema using dynamic contrast-enhanced magnetic resonance imaging.
abstract: Emphysema tends to be complicated by diffuse abnormalities in the pulmonary peripheral microvasculature. The aim of this study was to evaluate whether dynamic contrast-enhanced magnetic resonance imaging (MRI) could provide a valid assessment of pulmonary blood flow as an indicator of the severity of emphysema. To do this, the authors compared MRI data with the pathological findings in lung tissue. Dynamic contrast-enhanced MRI is a noninvasive method and can be used to repeatedly monitor clinicopathological severity. Using MRI clear pulmonary vascular information can be obtained easily, and the relative pulmonary blood flow in the lung parenchyma can be quantified.
authors.affiliation: Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. morinos@frontier.kyoto-u.ac.jp
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Morino
authors.forename: Toshinari
authors.initials: T
authors.lastname: Toba
authors.forename: Masato
authors.initials: M
authors.lastname: Araki
authors.forename: Takashi
authors.initials: T
authors.lastname: Azuma
authors.forename: Sadami
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tao
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagayasu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tagawa
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D003287:Contrast Media / Q000494:pharmacology; D004285:Dogs; D004646:Emphysema / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D019786:Gadolinium DTPA / Q000494:pharmacology; D008176:Lung Volume Measurements; D018810:Magnetic Resonance Angiography / Q000379:methods* / Q000592:standards; D010100:Oxygen / Q000097:blood; D010196:Pancreatic Elastase; D011652:Pulmonary Circulation; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D003287:Contrast Media; D002245:Carbon Dioxide; D010196:Pancreatic Elastase; D019786:Gadolinium DTPA; D010100:Oxygen