Gliomas and farm pesticide exposure in men: the upper midwest health study.
The National Institute for Occupational Safety and Health evaluated farm pesticide exposure and glioma risk in a study that included 457 glioma cases and 648 population-based controls, all adult men (18-80 yr old) and nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. Multiple logistic regressions were used to control for farm residence, age, age group, education, and exposure to other pesticides. No associations were found between glioma and 12 specific pesticides. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and found reduced glioma risk for insecticides (OR = 0.53, CI = 0.37-0.77), fumigants (OR = 0.57, CI = 0.34-0.95), and organochlorines (OR = 0.66, CI = 0.47-0.94). In analyses excluding proxy respondents (47% of cases) most CIs included 1.0. No positive association of farm pesticide exposure and glioma was found. Other farm exposures may explain the excess brain cancer risk seen in previous studies.
Ruder
Avima M
AM
Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. amr2@cdc.gov
Waters
Martha A
MA
Butler
Mary Ann
MA
Carreón
Tania
T
Calvert
Geoffrey M
GM
Davis-King
Karen E
KE
Schulte
Paul A
PA
Sanderson
Wayne T
WT
Ward
Elizabeth M
EM
Connally
L Barbara
LB
Heineman
Ellen F
EF
Mandel
Jack S
JS
Morton
Roscoe F
RF
Reding
Douglas J
DJ
Rosenman
Kenneth D
KD
Talaska
Glenn
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000453:epidemiology*; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005910:Glioma / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*; D018570:Risk Assessment; D012307:Risk Factors; D014922:Wisconsin / Q000453:epidemiology
D010575:Pesticides