title: Metal-metal oxide pH sensors for physiological application.
abstract: Metal-metal oxide electrodes provide robust and miniaturised pH sensors. Iridium oxide electrodes prepared by thermal oxidation and by anodisation are described and their relative merits discussed. The effects of chloride and protein adsorption on sensor performance are investigated using cyclic voltammetry and the mechanism by which Nafion membranes can stabilise sensor response is identified. Applications in cultured intervertebral disc are reported.
authors.affiliation: Department of Bioengineering, Imperial College, Chemical Engineering Building, Prince Consort Road, London SW7 2BY, United Kingdom.
authors.forename: Danny
authors.initials: D
authors.lastname: O'Hare
authors.forename: Kim H
authors.initials: KH
authors.lastname: Parker
authors.forename: C Peter
authors.initials: CP
authors.lastname: Winlove
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001826:Body Fluids / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D007495:Iridium / Q000737:chemistry*
chemical_list: C044458:iridium oxide; D007495:Iridium