Evaluation of pre- and posttransplantation serum interferon-gamma and soluble CD30 for predicting liver allograft rejection.
The aim of the present study was to identify whether the serum interferon-gamma (IFNgamma), a Th1 cytokine, or soluble CD30 (sCD30), a marker for activation of Th2 cytokine-producing T cells, predict acute cellular rejection episodes among liver graft patients. Pretransplant and posttransplant sera from 32 living donor liver transplant recipients obtained on days 1, 3, and 7 after surgery were tested for serum IFNgamma and sCD30 concentrations using commercial enzyme-linked immunosorbent assay kits. Recipients with an acute rejection episode (ARE) (n=14) displayed significantly higher IFNgamma concentrations pretransplant than did the patients with no ARE (n=18) (P<.05). The pretransplant serum levels of sCD30 were not different between the non-ARE and ARE groups. However, in comparison with the non-ARE group, who showed steadily decreasing serum sCD30 levels after transplantation, 12 among the 14 patients in the ARE group showed increasing sCD30 levels from day 1 to day 3 after transplantation (P<.05). These results suggest that the sCD30 increment during the early period after liver transplantation affects the immune response of rejection. This observation emphasizes the clinical relevance of serum sCD30, in addition to serum IFNgamma, as predictive markers for acute liver graft rejection.
Kim
K H
KH
Department of Thoracic and Cardiovascular Surgery, College of Medicine, Seoul National University, Seoul, Korea.
Oh
E-J
EJ
Jung
E-S
ES
Park
Y-J
YJ
Choi
J Y
JY
Kim
D-G
DG
Lee
K Y
KY
Kang
C S
CS
D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D006084:Graft Rejection / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D017730:Ki-1 Antigen / Q000097:blood*; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D011184:Postoperative Period; D011300:Preoperative Care; D012189:Retrospective Studies; D018418:Th2 Cells / Q000276:immunology*
D015703:Antigens, CD; D015415:Biomarkers; D017730:Ki-1 Antigen; D007371:Interferon-gamma