title: The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity.
abstract: The effect of introducing fluorine atoms or trifluoromethyl groups in either the peptidic chain or the C-terminal end of cationic pentapeptides is reported. Three series of amide and ester peptides were synthesised and their antimicrobial properties evaluated. An enhanced activity was found in those derivatives whose structure contained fluorine, suggesting an increase in their hydrophobicity.
authors.affiliation: Departament de Química Orgànica, Facultat de Farmàcia, Universitat de València, 46100 Burjassot, València, Spain.
authors.forename: Diana
authors.initials: D
authors.lastname: Giménez
authors.forename: Cecilia
authors.initials: C
authors.lastname: Andreu
authors.forename: Marcel lí
authors.initials: Ml
authors.lastname: del Olmo
authors.forename: Teresa
authors.initials: T
authors.lastname: Varea
authors.forename: Dolores
authors.initials: D
authors.lastname: Diaz
authors.forename: Gregorio
authors.initials: G
authors.lastname: Asensio
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000737:chemistry*; D002412:Cations / Q000737:chemistry; D015195:Drug Design; D005057:Eukaryotic Cells / Q000187:drug effects; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001593:Benzyl Compounds; D002412:Cations; D009842:Oligopeptides; D005461:Fluorine