Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines.
Methanolic extracts (25 microug/ml) of species belonging to the genera of Combretum, Terminalia and Pteleopsis, collected during a field expedition in Tanzania in 1999, were screened for their antiproliferative and cytotoxic effects against three human cancer cell lines (HeLa, cervical carcinoma; T 24, bladder carcinoma; and MCF 7, breast carcinoma). A leaf extract of Combretum fragrans and a fruit extract of C. zeyheri gave the strongest antiproliferative and cytotoxic effects of all the twenty-four extracts screened in this investigation. In contrast to the highly powerful leaf extract of C. fragrans, the root extract of this species gave no cytotoxic effects against the investigated cancer cell lines at a concentration of 25 microg/ml. The other investigated species of Combretum and Terminalia differed greatly in their cytotoxic potential. Root extracts of Terminalia sambesiaca and T. sericea gave the strongest cytotoxic effects of the five species of Terminalia used in this study. Eight of the twenty-four investigated plant extracts showed pronounced cytotoxic effects (<30% proliferation compared to the control) against the T 24 bladder cancer cells, seven against the HeLa cells and four against the MCF 7 cells.
Fyhrquist
P
P
Division of Clinical Chemistry and Folkhälsan Research Center, Institute for Preventive Nutrition, Medicine and Cancer, Biomedicum, P.O. Box 63, FIN-00014 University of Helsinki, Finland. pia.fyhrquist@helsinki.fi
Mwasumbi
L
L
Vuorela
P
P
Vuorela
H
H
Hiltunen
R
R
Murphy
C
C
Adlercreutz
H
H
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D001943:Breast Neoplasms / Q000188:drug therapy; D002277:Carcinoma / Q000188:drug therapy; D045744:Cell Line, Tumor; D029764:Combretaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D010936:Plant Extracts / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts