title: Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults.
abstract: The outcome of 81 adult aplastic anaemia patients who had successful cytogenetics at diagnosis and received immunosuppressive therapy was evaluated. Ten patients had an abnormal karyotype, six of which had a trisomy. Four of five evaluable patients with a trisomy responded. One patient with monosomy 7 achieved a complete response and later developed haemolytic paroxysmal nocturnal haemoglobinuria but no recurrence of monosomy 7. None of the patients with a non-numerical karyotypic abnormality responded. No significant differences in survival or later clonal disorders were observed between patients with a normal karyotype and those with an abnormal karyotype.
authors.affiliation: Department of Haematology, St George's Hospital, London, UK.
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
authors.forename: Carol
authors.initials: C
authors.lastname: Brooker
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Tooze
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Yi
authors.forename: Deborah
authors.initials: D
authors.lastname: Sage
authors.forename: David
authors.initials: D
authors.lastname: Turner
authors.forename: Pamela
authors.initials: P
authors.lastname: Kangasabapathy
authors.forename: Judith C W
authors.initials: JC
authors.lastname: Marsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D014314:Trisomy
chemical_list: D007166:Immunosuppressive Agents