APPLied mechanics: uncovering how adiponectin modulates insulin action.
Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.
Hosch
Sarah E
SE
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Olefsky
Jerrold M
JM
Kim
Jane J
JJ
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
C464801:APPL1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D052242:Adiponectin; C510733:Appl1 protein, mouse; D002352:Carrier Proteins; D007328:Insulin; D011956:Receptors, Cell Surface