title: Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder.
abstract: Temporal lobe and limbic structures may be abnormal in bipolar disorder. T2-weighted magnetic resonance imaging (MRI) scans frequently show deep white matter lesions. MRI was performed on 50 young (19-39 years) euthymic patients with bipolar disorder and 26 controls. Mean temporal lobe volumes were reduced in patients (right, 9.42 cm3; left, 6.33 cm3) but this could not but this could not be ascribed to a specific structure. Deep white matter lesions were present in 5 patients but no controls raising questions of their aetiological significance.
authors.affiliation: Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
authors.forename: Selim M
authors.initials: SM
authors.lastname: El-Badri
authors.forename: David A
authors.initials: DA
authors.lastname: Cousins
authors.forename: Sean
authors.initials: S
authors.lastname: Parker
authors.forename: Heather C
authors.initials: HC
authors.lastname: Ashton
authors.forename: Victor L
authors.initials: VL
authors.lastname: McAllister
authors.forename: I Nicol
authors.initials: IN
authors.lastname: Ferrier
authors.forename: P Brian
authors.initials: PB
authors.lastname: Moore
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002508:Cephalometry; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000473:pathology