Nature: a rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy.
The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (lambda (max) 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the chemistry, preclinical results, and brief clinical data of some of the most effective photosensitizers. The utility of the tumor-avid photosensitizers in developing multimodality agents (imaging and therapy) is also presented.
Pandey
Ravindra K
RK
Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. Ravindra.Pandey@roswellpark.org
Goswami
Lalit N
LN
Chen
Yihui
Y
Gryshuk
Amy
A
Missert
Joseph R
JR
Oseroff
Allan
A
Dougherty
Thomas J
TJ
D025541:Bacteriochlorophyll A / Q000737:chemistry / Q000494:pharmacology; D002734:Chlorophyll / Q000737:chemistry / Q000494:pharmacology; D003952:Diagnostic Imaging; D037741:Fullerenes; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology
D025541:Bacteriochlorophyll A; D037741:Fullerenes; D017319:Photosensitizing Agents; D002734:Chlorophyll