title: Visuospatial working memory deficits in adolescent onset schizophrenia.
abstract: This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while mid-dorsolateral and ventrolateral PFC functions remain intact: the current conceptualisation of schizophrenia as a progressive neurodevelopmental disorder is consistent with these results.
authors.affiliation: Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, 3052, Victoria, Australia. avance@unimelb.edu.au
authors.forename: A
authors.initials: A
authors.lastname: Vance
authors.forename: N
authors.initials: N
authors.lastname: Hall
authors.forename: M A
authors.initials: MA
authors.lastname: Bellgrove
authors.forename: M
authors.initials: M
authors.lastname: Casey
authors.forename: F
authors.initials: F
authors.lastname: Karsz
authors.forename: P
authors.initials: P
authors.lastname: Maruff
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D003342:Corpus Striatum / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D009415:Nerve Net / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D012559:Schizophrenia / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*