title: Presence of numerous stop codons in HIV-1 reverse transcriptase proviral DNA sequences from patients with virological response to HAART.
abstract: The impact of proviral DNA reverse transcriptase mutations on virological failure was evaluated in 50 HIV-1 HAART-treated patients switching from a protease inhibitor to a non-nucleoside reverse transcriptase inhibitor. Neither the M184I/V mutation detected in 12 patients nor stop codons at tryptophane positions detected in 13 patients were associated with virological failure. Stop codons appeared under successful therapy in 12 patients. Their presence should be assessed in studies with higher statistical power.
authors.affiliation: Laboratoire de Virologie, CHU/Hôpital Bichat Claude Bernard, 6 rue Henri Huchard, 75018 Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Makinson
authors.forename: Bernard
authors.initials: B
authors.lastname: Masquelier
authors.forename: Audrey
authors.initials: A
authors.lastname: Taieb
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Anne
authors.initials: A
authors.lastname: Waldner-Combernoux
authors.forename: Gilles
authors.initials: G
authors.lastname: Collin
authors.forename: Genevieve
authors.initials: G
authors.lastname: Chêne
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: François
authors.initials: F
authors.lastname: Raffi
authors.forename: Vincent
authors.initials: V
authors.lastname: Le Moing
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018388:Codon, Terminator; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011533:Proviruses / Q000235:genetics*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018388:Codon, Terminator; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase