ERK MAP kinase in G cell cycle progression and cancer.
The extracellular-signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling-related proteins, such as scaffold proteins and inhibitors. These proteins modulate ERK signaling and thereby could give variations in ERK signaling outputs that regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle progression from G0/G1 to S phase and cancer.
Torii
Satoru
S
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Yamamoto
Takuya
T
Tsuchiya
Yoshiki
Y
Nishida
Eisuke
E
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D018450:Disease Progression; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D016193:G1 Phase; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D015398:Signal Transduction
D048049:Extracellular Signal-Regulated MAP Kinases