title: Ligands for molecular imaging: the synthesis of bis(thiosemicarbazone) ligands.
abstract: Bis(thiosemicarbazones) have been of interest to chemists for over fifty years; they display antitumour, antibiotic and antiviral properties. Recently it has become apparent that they may also provide a convenient way of labelling biologically active molecules by using metallic radionuclides and/or fluorescence. Although apparently simple, the synthesis of bis(thiosemicarbazone) ligands can be problematic. This article provides a summary of the published literature, based on the synthetic strategies used and indicates some of the difficulties that may arise.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK. martin.christlieb@chem.ox.ac.uk
authors.forename: Martin
authors.initials: M
authors.lastname: Christlieb
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dilworth
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods; D006037:Glyoxal / Q000031:analogs & derivatives / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008024:Ligands; D012663:Semicarbazides / Q000737:chemistry; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007659:Ketones; D008024:Ligands; D012663:Semicarbazides; D013882:Thiosemicarbazones; D006037:Glyoxal; C005151:thiosemicarbazide