title: Delayed motherhood through oocyte and ovarian tissue cryopreservation - a perspective from Singapore.
abstract: Recent advances in oocyte and ovarian tissue cryopreservation technology have brought hope not only to women facing premature loss of ovarian function, but also to healthy women seeking delayed motherhood. This is a major issue of contention in healthcare ethics. Proponents of this new technology argue that this enables women to pursue educational and career goals in their youth, so that they have greater financial security for children in later life. Nevertheless, this argument may be flawed by the reality that even if the cryopreservation of oocytes and ovarian tissue were optimized in the future, this would in no way be a guaranteed route for women to have biological children later in life. Moreover, because only a limited amount of autologous reproductive material can be cryopreserved and stored for a single healthy woman, there is a risk of material depletion before reproductive success is attained. Another prime consideration is the increased morbidity and mortality associated with clinical assisted reproduction in older women. Hence, it is imperative that delayed motherhood through the cryopreservation of oocytes and ovarian tissues be viewed with extreme caution, and mandatory counselling should be given to all patients if such a medical procedure ultimately finds approval for widespread application.
authors.affiliation: Stem Cell Laboratory, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore. denhenga@nus.edu.sg
authors.forename: Boon Chin
authors.initials: BC
authors.lastname: Heng
mesh_terms: D015925:Cryopreservation; D005260:Female; D006801:Humans; D008423:Maternal Age; D009035:Mothers; D009865:Oocytes; D010053:Ovary; D016487:Parenting; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D012846:Singapore; D012959:Socioeconomic Factors