title: Brain and spinal cord haemorrhages associated with Angiostrongylus vasorum infection in four dogs.
abstract: Multifocal haemorrhages associated with Angiostrongylus vasorum infection were observed in the central nervous system of four dogs with neurological signs including depression, seizures, spinal pain and paresis. In magnetic resonance images the majority of the lesions were isointense or slightly hyperintense in T1-weighted images, hyperintense in T2-weighted images and hypointense in T2*-weighted (gradient echo) images, compatible with haemorrhages more than seven days old. Lesions were found in the brain of three of the dogs and in the spinal cord of two. The cerebrospinal fluid contained high concentrations of protein and evidence of erythrophagia. All the dogs had coagulopathy and pulmonary haemorrhage of varying severity. A vasorum larvae were detected in the faeces of each of the dogs. Neural A vasorum was confirmed at postmortem examination in two dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA.
authors.forename: A
authors.initials: A
authors.lastname: Wessmann
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: C R
authors.initials: CR
authors.lastname: Lamb
authors.forename: B
authors.initials: B
authors.lastname: Smyth
authors.forename: P
authors.initials: P
authors.lastname: Mantis
authors.forename: K
authors.initials: K
authors.lastname: Chandler
authors.forename: A
authors.initials: A
authors.lastname: Boag
authors.forename: G B
authors.initials: GB
authors.lastname: Cherubini
authors.forename: R
authors.initials: R
authors.lastname: Cappello
mesh_terms: D000801:Angiostrongylus / Q000472:pathogenicity*; D000818:Animals; D001760:Bleeding Time; D001772:Blood Cell Count; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000469:parasitology; D004285:Dogs; D017809:Fatal Outcome; D006470:Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D053609:Lethargy; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009192:Myelography / Q000662:veterinary; D011693:Purpura / Q000209:etiology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000662:veterinary; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D017206:Strongylida Infections / Q000150:complications / Q000662:veterinary*