Comparison of antitumor activities in tumor xenograft treatment.
To compare treatment effects with antitumor therapies, we proposed an intuitive approach to compare the antitumor effects of two different antitumor treatments by investigating tumor volumes which were measured in a given period of time. The approach is, in essence, a comparison of two unknown functions. The implementation of the approach is simple and straightforward. The approach is applied to analyze a real xenograft study of a new antitumor agent, irofulven, combined with irinotecan.
Liang
Hua
H
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, United States. hliang@bst.rochester.edu
D000465:Algorithms; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004195:Disease Models, Animal; D006801:Humans; D000077146:Irinotecan; D051379:Mice; D012717:Sesquiterpenes / Q000008:administration & dosage*; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C102714:irofulven; D000077146:Irinotecan; D002166:Camptothecin