title: Synthesis of cyclopropene alpha-amino acids via enantioselective desymmetrization.
abstract: [reaction: see text] The preparation of cyclopropene alpha-amino acids via the enantioselective desymmetrization of cyclopropene bis-carboxylic acid derivatives is described. The amino acids are stable to harsh reaction conditions, and a derivative has been incorporated into a tripeptide using conventional methods for peptide synthesis.
authors.affiliation: Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, 19716, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Fox
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002264:Carboxylic Acids; D003521:Cyclopropanes; D010455:Peptides; C021985:cyclopropene