title: Isotonic and hypertonic saline droplet deposition in a human upper airway model.
abstract: The evaporative and hygroscopic effects and deposition of isotonic and hypertonic saline droplets have been simulated from the mouth to the first four generations of the tracheobronchial tree under laminar-transitional-turbulent inspiratory flow conditions. Specifically, the local water vapor transport, droplet evaporation rate, and deposition fractions are analyzed. The effects of inhalation flow rates, thermodynamic air properties and NaCl-droplet concentrations of interest are discussed as well. The validated computer simulation results indicate that the increase of NaCl-solute concentration, increase of inlet relative humidity, or decrease of inlet air temperature may reduce water evaporation and increase water condensation at saline droplet surfaces, resulting in higher droplet depositions due to the increasing particle diameter and density. However, solute concentrations below 10% may not have a very pronounced effect on droplet deposition in the human upper airways.
authors.affiliation: Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695-7910, USA.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Clement
authors.initials: C
authors.lastname: Kleinstreuer
authors.forename: Chong S
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000280:Administration, Inhalation; D006801:Humans; D006813:Humidity; D007552:Isotonic Solutions / Q000493:pharmacokinetics; D008168:Lung / Q000502:physiology*; D008953:Models, Anatomic; D008954:Models, Biological; D010316:Particle Size; D015656:Respiratory Mechanics; D012462:Saline Solution, Hypertonic / Q000493:pharmacokinetics*; D013816:Thermodynamics; D014835:Volatilization; D017155:Wettability
chemical_list: D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic