title: Coronins: the return of the crown.
abstract: Coronins are highly conserved regulators of the actin cytoskeleton whose structure and biological function have remained mysterious until recently. They were originally identified in Dictyostelium, where they localize to actin-rich crown-like structures on the dorsal surface of cells. Coronins bind filamentous actin and the Arp2/3 complex and are involved in modulating actin dynamics. Unlike other known Arp2/3-binding proteins, coronins inhibit Arp2/3 nucleating activity. Genetic data from Dictyostelium, yeast and Drosophila indicate that coronins are important regulators of several actin-dependent physiological processes. Here, we review recent insights into mammalian coronin structure, function and regulation and identify key questions that remain unanswered in this field.
authors.affiliation: Lineberger Comprehensive Cancer Center and Department of Cell & Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Uetrecht
authors.forename: James E
authors.initials: JE
authors.lastname: Bear
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000502:physiology; D000199:Actins / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D003599:Cytoskeleton / Q000187:drug effects; D004023:Dictyostelium / Q000737:chemistry; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D016415:Sequence Alignment
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D008840:Microfilament Proteins; C072061:coronin proteins