title: Impact of acute blood pressure variability on ischemic stroke outcome.
abstract: BACKGROUND
  The authors previously reported a low initial emergency department (ED) blood pressure (BP) to be associated with a significantly increased risk of death at 90 days. In this article, they examine the impact of acute BP variability following onset of ischemic stroke.
  
  
  METHODS
  The study cohort consisted of 71 patients with stroke onset less than 24 hours. BP measurements were obtained every 5 minutes for the duration of the patient's ED stay. During the first 180 minutes, the median number of readings per patient was 9 (range 2 to 30).
  
  
  RESULTS
  The baseline median systolic (sBP) and diastolic (dBP) BPs were not different for the patients that died within 90 days compared with those that were alive (p = 0.91 for sBP and p = 0.27 for dBP). Patients who died within 90 days had a greater differential in their dBP during the first 180 minutes than the patients that were alive after 90 days (median 44.5 vs 25 mm Hg; Wilcoxon rank sum test, p < 0.001). A similar result was observed for sBP (median 47 vs 30 mm Hg; p = 0.047).
  
  
  CONCLUSIONS
  Wide fluctuation of blood pressure in the first 3 hours of the emergency department stay in patients with acute ischemic stroke appears to be associated with an increased risk of death at 90 days.
authors.affiliation: Department of Emergency Medicine, Mayo Clinic, Rochester, MN 55905, USA. stead.latha@mayo.edu
authors.forename: L G
authors.initials: LG
authors.lastname: Stead
authors.forename: R M
authors.initials: RM
authors.lastname: Gilmore
authors.forename: K C
authors.initials: KC
authors.lastname: Vedula
authors.forename: A L
authors.initials: AL
authors.lastname: Weaver
authors.forename: W W
authors.initials: WW
authors.lastname: Decker
authors.forename: R D
authors.initials: RD
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002545:Brain Ischemia / Q000175:diagnosis / Q000401:mortality*; D015331:Cohort Studies; D015897:Comorbidity; D004632:Emergency Medical Services / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000401:mortality*; D007022:Hypotension / Q000175:diagnosis / Q000401:mortality*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D020521:Stroke / Q000175:diagnosis / Q000401:mortality*; D016019:Survival Analysis; D015996:Survival Rate