title: Diagnostic performance of stress perfusion and delayed-enhancement MR imaging in patients with coronary artery disease.
abstract: OBJECTIVE
  To prospectively determine the accuracy of a combined magnetic resonance (MR) imaging approach (stress first-pass perfusion imaging followed by delayed-enhancement imaging) for depicting clinically significant coronary artery stenosis (> or = 70% stenosis) in patients suspected of having or known to have coronary artery disease (CAD), with coronary angiography serving as the reference standard.
  
  
  METHODS
  The committee on human research approved the study protocol, and all participants gave written informed consent. This study was HIPAA compliant. Forty-seven patients (38 men and nine women; mean age, 63 years +/- 5.3 [standard deviation]) scheduled for coronary angiography were prospectively enrolled: 33 were suspected of having CAD (group A) and 14 had experienced a previous myocardial infarction and were suspected of having new lesions (group B). The MR imaging protocol included cine function, gadolinium-enhanced stress and rest first-pass perfusion MR imaging, and delayed-enhancement MR imaging. Myocardial ischemia was defined as a segment with perfusion deficit at stress first-pass perfusion MR imaging and no hyperenhancement at delayed-enhancement imaging. Myocardial infarction was defined as an area with hyperenhancement at delayed-enhancement imaging.
  
  
  RESULTS
  One patient was excluded from analysis because of poor-quality MR images. Coronary angiography depicted significant stenosis in 30 of 46 patients (65%). In a per-vessel analysis (n = 138), stress first-pass perfusion MR imaging and delayed-enhancement imaging yielded sensitivity of 0.87, specificity of 0.89, and accuracy of 0.88, when compared with coronary angiography. The diagnostic accuracy of stress first-pass perfusion MR imaging and delayed-enhancement imaging was slightly better than that of stress and rest first-pass perfusion MR imaging in the entire population (0.88 vs 0.85), in group A (0.86 vs 0.82), and in group B (0.93 vs 0.90).
  
  
  CONCLUSIONS
  Stress first-pass perfusion MR imaging followed by delayed-enhancement imaging is an accurate method to depict significant coronary stenosis in patients suspected of having or known to have CAD.
authors.affiliation: Department of Radiology, Beneficencia Portuguesa Hospital, Sao Paulo, Brazil. rcury@partners.org
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cury
authors.forename: Cesar A M
authors.initials: CA
authors.lastname: Cattani
authors.forename: Luiz A G
authors.initials: LA
authors.lastname: Gabure
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Racy
authors.forename: Jose M
authors.initials: JM
authors.lastname: de Gois
authors.forename: Uwe
authors.initials: U
authors.lastname: Siebert
authors.forename: Sergio S
authors.initials: SS
authors.lastname: Lima
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Brady
mesh_terms: D000628:Aminophylline / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D023921:Coronary Stenosis / Q000175:diagnosis*; D004176:Dipyridamole / Q000494:pharmacology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology; D017202:Myocardial Ischemia / Q000473:pathology; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D003287:Contrast Media; D014665:Vasodilator Agents; D000628:Aminophylline; D004176:Dipyridamole; D019786:Gadolinium DTPA