Design and synthesis of novel chemokine analogs derived from vMIP-II.
Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.
Wang
Jun
J
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Kumar
Santhosh
S
Choi
Won-Tak
WT
Dong
Changzhi
C
Huang
Ziwei
Z
D000595:Amino Acid Sequence; D054407:Chemokine CCL4; D018925:Chemokines / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics
D054407:Chemokine CCL4; D018925:Chemokines; D019402:Macrophage Inflammatory Proteins; D014764:Viral Proteins