title: Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report.
abstract: OBJECTIVE
  To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers.
  
  
  METHODS
  We evaluated 9 nondiabetic patients aged 26.6 years (median 26 years, range 17 to 41 years) and matched volunteers, using the frequently sampled intravenous glucose tolerance test, minimal model analysis, and fasting adiponectin levels.
  
  
  RESULTS
  The mean insulin sensitivity index of the patients was 42% lower than that of the healthy volunteers (P = 0.026), with inadequate compensation in insulin secretion. Patients with schizophrenia tended to have reduced adiponectin levels (P = 0.055).
  
  
  CONCLUSIONS
  By direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario. Tony_Cohn@camh.net
authors.forename: Tony A
authors.initials: TA
authors.lastname: Cohn
authors.forename: Gary
authors.initials: G
authors.lastname: Remington
authors.forename: Robert B
authors.initials: RB
authors.lastname: Zipursky
authors.forename: Azar
authors.initials: A
authors.lastname: Azad
authors.forename: Philip
authors.initials: P
authors.lastname: Connolly
authors.forename: Thomas M S
authors.initials: TM
authors.lastname: Wolever
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009864:Ontario; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D052242:Adiponectin