[Influence of intracerebroventricular infusion of beta-amyloid peptide on learning dynamics in Wistar and non-linear rats].
Effect of intracerebroventricular infusion of beta-amyloid peptide fragment Abeta(25-35) on light-dark discrimination in a Y-maze with positive food reinforcement, assessed as a decrease in the number of errors, was investigated in Wistar rats and non-linear rats. We proposed to use exponential mathematical model for the learning curve that represents the transfer function for the first order system together with regression analysis. Dynamics of learning in Wistar and non-linear rats coincided with the model. Injection ofbeta-amyloid into the right lateral ventricle of the brain led to a disruption in performance between the first and the second session without total cessation of the learning process. This disappearance of the curve may be the first sign of the initial effect of beta-amyloid because Student's t-test did not reveal any significant difference between control and amyloid-treated Wistar rats. Beta-amyloid in non-linear rats only decreased the velocity of learning though kept being similar to the mathematical model. These results suggest that the non-linear rats possess some genetically specified defense mechanism against damaging action of beta-amyloid.
D000544:Alzheimer Disease / Q000139:chemically induced / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008954:Models, Biological; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D016229:Amyloid beta-Peptides; D010455:Peptides