title: Risk of allergy to food proteins in topical medicinal agents and cosmetics.
abstract: The risk of allergy to food proteins in cosmetics and topical medicinal agents is poorly evaluated. IgE dependent contact urticaria and contact dermatitis are observed. Eleven cases (7 infants and 4 women) are reported. Wheat, egg, oats, milk, peanut proteins are incriminated by prick-tests or atopy patch-tests. Cases are related to a previous food allergy and other ones may indicate primary sensitization to topical creams mainly used for skin care of atopic dermatitis. A consecutive exercise induced anaphylaxis to wheat and a long lasting sensitization to wheat have been observed. A clear and accurate identification of food allergens in cosmetics and topical agents is necessary. Given the hyper-permeability of infant skin, topical products containing food proteins of known allergenicity are contra-indicated for neonates, and for infants with atopic dermatitis, which may be associated with skin hyper-permeability.
authors.affiliation: Service de Médecine Interne, Immunologie Clinique et Allergologie, Hôpital Universitaire de Nancy, 54035 Nancy.
authors.forename: F
authors.initials: F
authors.lastname: Codreanu
authors.forename: M
authors.initials: M
authors.lastname: Morisset
authors.forename: V
authors.initials: V
authors.lastname: Cordebar
authors.forename: G
authors.initials: G
authors.lastname: Kanny
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003358:Cosmetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry*; D003877:Dermatitis, Contact / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005502:Food; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011506:Proteins / Q000009:adverse effects* / Q000276:immunology; D012307:Risk Factors; D012882:Skin Tests
chemical_list: D003358:Cosmetics; D004364:Pharmaceutical Preparations; D011506:Proteins