title: Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk.
abstract: In breast milk and paired blood samples of nine HIV-1-infected lactating women, we undertook a study to detect a CD4 T-cell reservoir and to investigate its capacity to enter viral production after activation. Breast milk-infected CD4 T cells have a greater capacity to produce viral particles actively than blood CD4 T cells. This observation may explain the apparent paradox of a transmissible viral infection from a body fluid with a low viral concentration.
authors.affiliation: Research Unit 145 (UMR 145) Institute for Research and Development (IRD) and University of Montpellier 1, Montpellier, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Becquart
authors.forename: Gaël
authors.initials: G
authors.lastname: Petitjean
authors.forename: Yassine Al
authors.initials: YA
authors.lastname: Tabaa
authors.forename: Diane
authors.initials: D
authors.lastname: Valéa
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Huguet
authors.forename: Edouard
authors.initials: E
authors.lastname: Tuaillon
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meda
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vendrell
authors.forename: Philippe
authors.initials: P
authors.lastname: Van de Perre
mesh_terms: D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008895:Milk, Human / Q000821:virology*; D014779:Virus Replication
chemical_list: D004279:DNA, Viral