title: [Attitudes towards predictive genetic testing for Alzheimer's disease].
abstract: Most neuropsychiatric disorders have a complex aetiology. Discovery of the underlying genetics will provide insights into the disorders and allow the subsequent development of therapeutic interventions based upon an understanding of causality. The first vulnerability genes in Alzheimer's disease (AD) have been identified. The contribution of each vulnerability gene to the disorder is limited and does not enable prediction of course and onset in individual cases, only modification of the a priori risk. However, people may wish to be informed about this modification. Professionals have not favoured this form of predictive testing due to an awareness of its limitations and its potential for harm. However, little is known about public attitudes and understanding of such genetic testing in neuropsychiatric disorders. The aim of our study was to assess the attitudes of the general population and to explore the influence on these attitudes of knowledge about the illness and the understanding of risk information. In our study, a representative sample of the German general population (n=2001), relatives of patients with Alzheimer's disease (n=101) and physicians (n=43) were interviewed about their attitudes towards genetic tests for Alzheimer's disease and their perception and interpretation of risk information. To assess the influence of genetic counselling on these factors, 234 people were questioned before, and four weeks after, they were provided with detailed relevant information. Our results indicate that a substantial proportion of the German population (57%) is in favour of psychiatric genetic testing for AD in general. Even when the explanatory power of a genetic test is limited, a substantial proportion of the population (47%) expressed an interest in genetic testing. Counselling slightly decreased the interest in having a genetic test for oneself (from 47% to 38%). Physicians were more hesitant than both relatives and the general population concerning predictive genetic testing. Only a minority (11%) favoured prenatal genetic testing. Our results also show that both knowledge about AD and the capacity to interpret risk estimates are limited. While physicians' estimation of their personal risk for developing AD approximated to the actual average risk for the population, people in the general population and the relatives of AD patients tended to overestimate their personal risk. However, most of the general population still perceived this risk as average or low. While most physicians could correctly interpret information regarding the probability of risk, only one third of AD patients' relatives or members of the general population could. As the decision of an individual to undergo predictive testing relies mainly on his understanding of risk, the ability to correctly interpret risk information will be of crucial importance in the future. From a medical perspective, the prevailing approach of professional associations to genetic testing appears reasonable and therefore should not be changed at present.
authors.affiliation: Zentralinstitut für Seelische Gesundheit, Abteilungen Gerontopsychiatrie sowie Genetische Epidemiologie in der Psychiatrie, J5, 68159, Mannheim, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Illes
authors.forename: T
authors.initials: T
authors.lastname: Bernhardt
authors.forename: K
authors.initials: K
authors.lastname: Prell
authors.forename: C
authors.initials: C
authors.lastname: Rietz
authors.forename: G
authors.initials: G
authors.lastname: Rudinger
authors.forename: L
authors.initials: L
authors.lastname: Frölich
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Rietschel
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics* / Q000451:nursing*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001291:Attitude of Health Personnel; D001294:Attitude to Health; D005260:Female; D006580:Genetic Carrier Screening; D005817:Genetic Counseling / Q000523:psychology; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D005820:Genetic Testing / Q000523:psychology*; D005838:Genotype; D007722:Health Knowledge, Attitudes, Practice; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk
chemical_list: D053327:Apolipoprotein E4