title: Regulation of the Chlamydia trachomatis histone H1-like protein Hc2 is IspE dependent and IhtA independent.
abstract: The chlamydial histone-like proteins, Hc1 and Hc2, function as global regulators of chromatin structure and gene expression. Hc1 and Hc2 expression and activity are developmentally regulated. A small metabolite that disrupts Hc1 interaction with DNA also disrupts Hc2 interactions; however, the small regulatory RNA that inhibits Hc1 translation is specific to Hc1.
authors.affiliation: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Grieshaber
authors.forename: Janet Burgess
authors.initials: JB
authors.lastname: Sager
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Dooley
authors.forename: Stanley F
authors.initials: SF
authors.lastname: Hayes
authors.forename: Ted
authors.initials: T
authors.lastname: Hackstadt
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002692:Chlamydia trachomatis / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D004926:Escherichia coli / Q000254:growth & development; D015964:Gene Expression Regulation, Bacterial; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C082102:HctB protein, Chlamydia trachomatis; D006657:Histones; D017853:Phosphotransferases (Alcohol Group Acceptor)