Patient with double cancer--successfully treated.
BACKGROUND
Etiology of thrombosis in malignant diseases is multifactorial, and mechanisms that lead to thrombosis include release of the procoagulants from tumor cells (PC), factor related to bed rest, infections, as well as oncological therapy --chemotherapy, hormones, radiotherapy and surgical treatment. Thrombocytosis has frequently been found to be associated with various malignancies.


METHODS
53 years old female patient hospitalised because of hypopharingeal cancer with metastasis in the left neck. Her state was complicated with deep leg vein trombosis and pseudomonas infection. Persistent thrombocitosis in laboratory monitoring indicated more adequate diagnostic procedures, which led to discovering of Chorioidal Malignant Mellanoma as a second cancer. She was treated: surgically, with antibiotics, with anticoagulants and radiotherapy. Patient was discharged from the hospital in good health condition, free of any other symptom of the malignant disease.


CONCLUSIONS
Presense of thrombocytosis and idiopatic thrombosis can suggest occult malignancy. It would be prudent to further evaluate the relationship of trombotic events, trombocitosis and head and neck tumors. We suggest anticoagulants to prevent thromboembolic complications, affect the angiogenesis and prevent development of metastatic disease. It may lead to lower mortality rate.
Djukić
V B
VB
Institute of Othorhynolaringology and maxillofacial surgery.
Kastratović
D A
DA
Pendjer
I P
IP
Majstorović
B M
BM
Nikolić
Lj I
LjI
Boricić
I V
IV
Vujicić
Z N
ZN
D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000628:therapy*; D002830:Choroid Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000628:therapy*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000628:therapy*; D020246:Venous Thrombosis / Q000209:etiology