title: Membrane guanylyl cyclase receptors: an update.
abstract: Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance.
authors.affiliation: Cecil H. & Ida Green Center for Reproductive Biology Sciences, and Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9051, USA. david.garbers@utsouthwestern.edu
authors.forename: David L
authors.initials: DL
authors.lastname: Garbers
authors.forename: Ted D
authors.initials: TD
authors.lastname: Chrisman
authors.forename: Phi
authors.initials: P
authors.lastname: Wiegn
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katafuchi
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Albanesi
authors.forename: Vincent
authors.initials: V
authors.lastname: Bielinski
authors.forename: Barbara
authors.initials: B
authors.lastname: Barylko
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Redfield
authors.forename: John C
authors.initials: JC
authors.lastname: Burnett
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D006162:Guanylate Cyclase / Q000235:genetics; D006801:Humans; D007422:Intestines / Q000502:physiology; D008246:Lysophospholipids / Q000378:metabolism; D008954:Models, Biological; D020097:Natriuretic Peptide, Brain / Q000502:physiology; D020098:Natriuretic Peptide, C-Type / Q000502:physiology; D045265:Natriuretic Peptides / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics; D050705:Receptors, Guanylate Cyclase-Coupled / Q000502:physiology*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D045265:Natriuretic Peptides; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; C060506:sphingosine 1-phosphate; D009320:Atrial Natriuretic Factor; D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; D050705:Receptors, Guanylate Cyclase-Coupled; C091715:atrial natriuretic factor receptor A; D013110:Sphingosine