title: The phytoalexins from cauliflower, caulilexins A, B and C: isolation, structure determination, syntheses and antifungal activity.
abstract: Our continuous search for phytoalexins from crucifers led us to examine phytoalexin production in florets of cauliflower (Brassica oleracea var. botrytis) under abiotic (UV light) elicitation. Four known (isalexin, S-(-)-spirobrassinin, 1-methoxybrassitin, brassicanal C) and three new (caulilexins A-C) phytoalexins were isolated. The syntheses and antifungal activity of caulilexins A-C against the economically important pathogenic fungi Leptosphaeria maculans, Rhizoctonia solani and Sclerotinia sclerotiorum, and the first synthesis of brassicanal C are reported.
authors.affiliation: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. soledade.pedras@usask.ca
authors.forename: M Soledade C
authors.initials: MS
authors.lastname: Pedras
authors.forename: Mohammed G
authors.initials: MG
authors.lastname: Sarwar
authors.forename: Mojmir
authors.initials: M
authors.lastname: Suchy
authors.forename: Adewale M
authors.initials: AM
authors.lastname: Adio
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D001937:Brassica / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007919:Leptospira / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects; D012717:Sesquiterpenes; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000094162:Phytoalexins
chemical_list: D000935:Antifungal Agents; D007211:Indoles; D012717:Sesquiterpenes; D013729:Terpenes; C514565:caulilexin A; C514566:caulilexin B; C514567:caulilexin C; D000094162:Phytoalexins