title: ent-Trachylobane diterpenoids from Xylopia langsdorffiana.
abstract: Two new diterpenes of the ent-trachylobane type were isolated from the stems of Xylopia langsdorffiana, ent-7alpha-acetoxytrachyloban-18-oic acid (1) and ent-7alpha-hydroxytrachyloban-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. X-ray crystallography of 1 was used to confirm its structure. The cytotoxic activity of 1 against V79 fibroblasts and rat hepatocytes was investigated.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970, João Pessoa, Paraíba, Brazil.
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
authors.forename: Karine F
authors.initials: KF
authors.lastname: Queiroga
authors.forename: Marianna Vieira B
authors.initials: MV
authors.lastname: Silva
authors.forename: Margareth F F M
authors.initials: MF
authors.lastname: Diniz
authors.forename: José M B
authors.initials: JM
authors.lastname: Filho
authors.forename: Emidio V L
authors.initials: EV
authors.lastname: da-Cunha
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: de Simone
authors.forename: João X de Araújo
authors.initials: JX
authors.lastname: Júnior
authors.forename: Patrícia S
authors.initials: PS
authors.lastname: Melo
authors.forename: Marcela
authors.initials: M
authors.lastname: Haun
authors.forename: Marcelo Sobral
authors.initials: MS
authors.lastname: da Silva
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D001938:Brazil; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004224:Diterpenes