title: Factors influencing visual and clinical outcome in Nigerian patients with cranial meningioma.
abstract: We retrospectively analysed the impact of selected clinicopathological factors on visual and clinical outcome in patients with histologically verified cranial meningioma. The 60 patients analysed for tumour characteristics consisted of 32 females and 28 males (sex ratio 1.1:1) aged 9-77 years (mean 40 years) seen between 1977 and 1999 at the University College Hospital, Ibadan, Nigeria. The patients for whom sufficient clinical data was available (n=35) presented within 2-60 months (mean 18 months) of symptom onset with large tumours (mean size 52 mm), and perifocal oedema (26/35), poor vision, focal neurological deficits, seizures and clinical evidence of intracranial hypertension. The most common tumour site was the convexity. There was loss of vision in 30/35 (85.7%) patients. Loss of vision was significantly related to tumour site and tumour size as well as perifocal oedema, (P<0.05). The case-mortality rate was 11.4% at 1 month and 20% at 6 months post-operation and was significantly correlated with intracranial hypertension. Neither age nor sex affected the outcome (P>0.05).
authors.affiliation: Department of Surgery, College of Medicine, University of Ibadan, University College Hospital, PMB 5116, Ibadan, Nigeria.
authors.forename: T O
authors.initials: TO
authors.lastname: Odebode
authors.forename: E E
authors.initials: EE
authors.lastname: Akang
authors.forename: M T
authors.initials: MT
authors.lastname: Shokunbi
authors.forename: A O
authors.initials: AO
authors.lastname: Malamo
authors.forename: A O
authors.initials: AO
authors.lastname: Ogunseyinde
mesh_terms: D001932:Brain Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D002675:Child, Preschool; D003399:Craniotomy / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D008579:Meningioma / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D009422:Nervous System Diseases / Q000209:etiology; D009493:Neurosurgery / Q000379:methods; D009549:Nigeria / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D014785:Vision, Ocular / Q000502:physiology*