title: New entry into beta-lactams via reaction of dimethoxycarbene with isocyanates.
abstract: [reaction: see text] Highly substituted beta-lactams have been isolated as the major product of the reaction of dimethoxycarbene with selected isocyanates. This reaction offers the potential for rapid access into a variety of highly functionalized species.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA. jhr@chem.wayne.edu
authors.forename: James H
authors.initials: JH
authors.lastname: Rigby
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Brouet
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Burke
authors.forename: Stephanie
authors.initials: S
authors.lastname: Rohach
authors.forename: Shyama
authors.initials: S
authors.lastname: Sidique
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Heeg
mesh_terms: D006838:Hydrocarbons / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D006838:Hydrocarbons; D017953:Isocyanates; D047090:beta-Lactams; C030011:carbene; D008697:Methane