title: [The intensity of free radical oxidation and catalytic properties of the rat liver NADP-isocitrate dehydrogenase in the norm and in toxic hepatitis].
abstract: Parameters of hepatic free radical oxidation and catalytic properties of NADP-isocitrate dehydrogenase (EC 1.1.1.42; NADP-IDH) have been investigated in normal rats and under conditions of toxic hepatitis. Development of hepatitis was accompanied by the increase of conjugated dienes, malondialdehyde and some chemiluminescence parameters. Toxic hepatitis was also accompanied by the increase of liver NADP-IDH. Homogenous preparations of liver NADP-IDH from normal and toxic rats exhibited different sensitivity to effectors studied (Fe2+, Ca2+, H2O2, reduced glutatione).
authors.forename: E M
authors.initials: EM
authors.lastname: Andreeshcheva
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.forename: V G
authors.initials: VG
authors.lastname: Artiukhov
authors.forename: T I
authors.initials: TI
authors.lastname: Rakhmanova
authors.forename: L V
authors.initials: LV
authors.lastname: Matasova
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism*; D004789:Enzyme Activation; D005609:Free Radicals; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D005609:Free Radicals; D007521:Isocitrate Dehydrogenase; C039355:isocitrate dehydrogenase (NADP+)