title: Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep.
abstract: This paper describes in vitro and in vivo anthelmintic activities of Swertia chirata. In vitro studies revealed that at 25 mg/ml (P>/=0.05) the crude aqueous (CAE) and methanolic extracts (CME) of S. chirata whole plant showed an anthelmintic effect on live Haemonchus contortus. Moreover, in the in vivo study, the whole plant of S. chirata administered as crude powder (CP), CAE and CME at the dose of 3 g/kg to sheep naturally infected with mixed species of gastrointestinal nematodes, showed a significant reduction in egg per gram of faeces.
authors.affiliation: Chemotherapy Laboratory, Department of Veterinary Parasitology, University of Agriculture, Faisalabad, 38040, Pakistan. zafaruaf@yahoo.com
authors.forename: Zafar
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Muhammad
authors.initials: M
authors.lastname: Lateef
authors.forename: Muhammad Nisar
authors.initials: MN
authors.lastname: Khan
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
authors.forename: Muhammad Shoaib
authors.initials: MS
authors.lastname: Akhtar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D009348:Nematoda / Q000187:drug effects*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D010270:Parasite Egg Count; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology; D029967:Swertia
chemical_list: D000969:Antinematodal Agents; D010936:Plant Extracts