title: Influence of anatomy and head position on intranasal drug deposition.
abstract: The objective of this study was to determine the influence of individual anatomical differences on intranasal drug deposition. The data of a comparison of seven different administration techniques in ten healthy volunteers was used in this single-blind crossover pilot study. After intranasal administration of a dyed test formulation, endoscopic video imaging was done on seven non-sequential days. The deposition pattern per individual around the head of the middle turbinate was analyzed for each technique and correlated with the individual anatomy. Decreased deposition of dyed test formulation in the target area around the head of the middle turbinate was observed in the presence of minor septal deviations, narrow nasal valve areas, or inferior turbinate hypertrophy; a lateral head position helps to bypass a minor septal deviation. Although results are preliminary, we conclude that anatomy and head position are important factors in the deposition of topical nasal drugs and may be the key to improving individual local nasal (steroid) treatment.
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, VU University Medical Center, KNO 1D-116, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. P.Merkus@VUmc.nl
authors.forename: Paul
authors.initials: P
authors.lastname: Merkus
authors.forename: Fenna A
authors.initials: FA
authors.lastname: Ebbens
authors.forename: Barbara
authors.initials: B
authors.lastname: Muller
authors.forename: Wytske J
authors.initials: WJ
authors.lastname: Fokkens
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000730:Androstadienes / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018592:Cross-Over Studies; D004724:Endoscopy; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000188:drug therapy; D009666:Nose / Q000033:anatomy & histology*; D010865:Pilot Projects; D011187:Posture; D012220:Rhinitis / Q000188:drug therapy; D016037:Single-Blind Method; D012852:Sinusitis / Q000188:drug therapy; D016896:Treatment Outcome; D014420:Turbinates / Q000033:anatomy & histology; D014743:Videotape Recording
chemical_list: D000336:Aerosols; D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone