Speech apraxia without oral apraxia: can normal brain function explain the physiopathology?
Apraxia of speech, usually associated with stroke, refers to the inability to perform speech motor movements typically with an intact ability to execute non-speech oral movements. It is uncertain whether apraxia of speech results from damage affecting the insula or the inferior frontal gyrus. The controversy started because of conflicting results from studies investigating patients with disrupted brain structure, when dysfunction of both sites can coexist. We conducted a functional magnetic resonance imaging study of individuals without neurological disorders comparing speech and non-speech movements. Speech movements did not recruit the insula, but activated the left inferior frontal gyrus, suggesting that Broca's area, but not the insula, is critical for speech articulation.
Bonilha
Leonardo
L
Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29209, USA.
Moser
Dana
D
Rorden
Chris
C
Baylis
Gordon C
GC
Fridriksson
Julius
J
D000293:Adolescent; D000328:Adult; D001072:Apraxias / Q000145:classification / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001184:Articulation Disorders / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D013061:Speech Acoustics; D013068:Speech Production Measurement / Q000379:methods; D014055:Tomography, Emission-Computed / Q000379:methods