[Renal transplantation with positive crossmatch].
BACKGROUND
Lymphocytotoxic antibodies reduce the expectancy of renal transplantation due to the increased risk of a positive crossmatch.


METHODS
We analyzed the evolution of eight kidney transplants performed in our unit in presence of a positive crossmatch with historical T and/or B lymphocyte positive crossmatches.


RESULTS
Mean panel reactivity was 76,6 +/- 25,7% (r: 22-100%), been higher than 75% in six patients. Six patients were recipients of a second or third transplant. Immunosuppression consisted of quadruple therapy including induction with thymoglobuline. Five patients had delayed graft function, and one had primary non-function of the graft. One patient lost her graft due to chronic allograft nephropathy in the second year postransplantation. Six patients maintained a good renal function (serum creatinine 1,2 +/- 0,5 mg/dl, proteinuria 0,20 +/- 0,34 g/day).


CONCLUSIONS
Renal transplantation in presence of a positive cross-match with historical serum and T lymphocytes and/or B lymphocytes, was followed by a satisfactory graft survival.
Sancho
A
A
Servicio de Nefrología, Hospital Universitari Dr Peset, Valencia. asanchoc@senefro.org
Gavela
E
E
Crespo
J F
JF
Górriz
J L
JL
Avila
A
A
Nuñez
A
A
Molina
P
P
García-Ramos
J L
JL
Montoro
J
J
Pallardó
L M
LM
D000328:Adult; D000368:Aged; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies