title: [Diffuse panbronchiolitis in an Asian woman with severely obstructed pulmonary disease].
abstract: A 41-year-old woman was referred for severely obstructed pulmonary disease 4 years after she stopped smoking. Treatment for chronic obstructive pulmonary disease (COPD) had no effect and lung function worsened in the following years. The clinical, radiological and pathological characteristics led us to the diagnosis of diffuse panbronchiolitis. She was treated with clarithromycin. After 1 year, major improvement was seen in clinical, radiological and spirometric features. Diffuse panbronchiolitis is a rare obstructive disorder that is usually seen in people of Japanese descent. Patients respond well to treatment with low-dose macrolide treatment.
authors.affiliation: Universitair Medisch Centrum St Radboud, Nijmegen.
authors.forename: C J
authors.initials: CJ
authors.lastname: Majoor
authors.forename: A L
authors.initials: AL
authors.lastname: Cox
authors.forename: R P
authors.initials: RP
authors.lastname: Aliredjo
authors.forename: P N R
authors.initials: PN
authors.lastname: Dekhuijzen
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D044466:Asian People; D001988:Bronchiolitis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D017291:Clarithromycin / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin