title: Serotypes of Streptococcus pneumoniae isolated from blood and cerebrospinal fluid related to vaccine serotypes and to clinical characteristics.
abstract: Pneumococci isolated from blood and cerebrospinal fluid from 1998 to 2001 in 2 counties in south-west Sweden were serotyped with the capsular reaction test. Of the 836 strains, 353 (42%), 598 (72%) and 789 (94%) belonged to serotypes included in the 7- and 11-valent pneumococcal conjugate vaccines and in the 23-valent polysaccharide vaccine, respectively. The most common serotype was type 1 (119 isolates) followed in descending frequency by serotypes 7F, 9V, 14, 4 and 12F (90-49 isolates per serotype). The coverage rates of the 7- and 11-valent conjugate vaccines among 58 strains isolated from children and adolescents 0-19 y of age were 46% and 93%, respectively. A comparison of clinical characteristics of infections caused by different serotypes showed that types 1 and 7F were less commonly associated with severe underlying diseases, that patients infected with these serotypes were younger than the average and, thus, had a lower case-fatality rate.
authors.affiliation: Queen Silvia Children's Hospital, Göteborg, Sweden. Stefan.berg@pediat.gu.se
authors.forename: Stefan
authors.initials: S
authors.lastname: Berg
authors.forename: Birger
authors.initials: B
authors.lastname: Trollfors
authors.forename: Elisabet
authors.initials: E
authors.lastname: Persson
authors.forename: Erik
authors.initials: E
authors.lastname: Backhaus
authors.forename: Peter
authors.initials: P
authors.lastname: Larsson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ek
authors.forename: Berndt E
authors.initials: BE
authors.lastname: Claesson
authors.forename: Lars
authors.initials: L
authors.lastname: Jonsson
authors.forename: Gunilla
authors.initials: G
authors.lastname: Rådberg
authors.forename: Siv
authors.initials: S
authors.lastname: Johansson
authors.forename: Torvald
authors.initials: T
authors.lastname: Ripa
authors.forename: Margit S
authors.initials: MS
authors.lastname: Kaltoft
authors.forename: Helle Bossen
authors.initials: HB
authors.lastname: Konradsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D011008:Pneumococcal Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000382:microbiology*; D012703:Serotyping; D022541:Streptococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate