title: Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.
abstract: A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERbeta and were highly selective.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. ken_wildonger@merck.com
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Wildonger
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Ratcliffe
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
mesh_terms: D047629:Estrogen Receptor beta / Q000737:chemistry* / Q000378:metabolism*; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
chemical_list: D047629:Estrogen Receptor beta; D005449:Fluorenes; D008024:Ligands; D006859:Hydrogen