[Modification of the method for preparing rabbit liver VX2 tumor model and its MRI findings].
OBJECTIVE
To improve the method for preparing rabbit VX2 liver tumor model and observe the magnetic resonance imaging (MRI) features of the implanted tumors.


METHODS
Sixteen adult New Zealand white rabbits were assigned randomly into 4 equal groups, and VX2 tumor tissues were implanted into the right and left liver lobes with spiral CT guidance. Plain and contrast-enhanced MR scan and pathological analysis were performed in different stages (14, 18, 22 and 26 days) after tumor implantation.


RESULTS
Tumor implantation was successful in all the rabbits, and 18 to 22 days after tumor implantation, the diameters of the tumor ranged from 1 to 2 cm, which allowed observation and study. In plain MR scans, lower or equivalent tumor signal in comparison with hepatic parenchyma was observed, and contrast-enhanced scans produced obvious enhancement of the tumor edges. At 22 days after tumor implantation, obvious necrosis was observed in the center of the tumor.


CONCLUSIONS
This method of preparing rabbit VX2 liver tumor model with spiral CT guidance is simple and convenient, and the tumors can be observed effectively with dynamic plain and contrast-enhanced MR scans.
Quan
Xian-yue
XY
Imaging Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. quanxianyue@163.com
Xie
Wei
W
Zhang
Xue-lin
XL
Sun
Xi-jie
XJ
Zhu
Xing-li
XL
Yan
Zheng
Z
Liang
Wen
W
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009368:Neoplasm Transplantation; D011817:Rabbits; D011897:Random Allocation; D014057:Tomography, X-Ray Computed