Outbreak in Alberta of community-acquired (USA300) methicillin-resistant Staphylococcus aureus in people with a history of drug use, homelessness or incarceration.
BACKGROUND
The USA300 strain of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause severe infection and is increasingly recognized as a cause of community outbreaks. In 2004, an outbreak was identified in the Calgary Health Region (CHR).


METHODS
MRSA isolates were identified with standard methods at a central regional laboratory and typed via pulsed-field gel electrophoresis (PFGE). Isolates were tested by PCR for mecA, Panton-Valentine leukocidin (PVL), SCCmec, and spa genes. Cases were defined as such if a clinical isolate of the USA300 strain was noted between January 1 and September 30, 2004, and the patient had lived or traveled in CHR within 2 years before symptom onset. Demographic, clinical and risk data on all such cases were collected from several sources for statistical analysis. A case was defined as high-risk if the patient had a history of drug use, homelessness or incarceration.


RESULTS
Of 40 isolates with the USA300 PFGE pattern, all tested positive for PVL, SCCmec type IVa and spa type 008. Almost all infections (39/40, 98%) involved skin and soft tissues, except for 1 death from necrotizing hemorrhagic pneumonia; a notable proportion (38%) required hospital admission or intravenous antimicrobial therapy. The outbreak centred on the high-risk population in CHR (70%; risk ratio 169.4, 95% confidence interval 86.1-333.0).


CONCLUSIONS
People with histories of illicit drug use, homelessness or recent incarceration were at highest risk for infection with CA-MRSA. The emergence and spread of this virulent strain has important implications for treatment and public health in Canada.
Gilbert
Mark
M
Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, Ont.
MacDonald
Judy
J
Gregson
Dan
D
Siushansian
Jennifer
J
Zhang
Kunyan
K
Elsayed
Sameer
S
Laupland
Kevin
K
Louie
Tom
T
Hope
Karen
K
Mulvey
Michael
M
Gillespie
John
J
Nielsen
Diane
D
Wheeler
Virginia
V
Louie
Marie
M
Honish
Agnes
A
Keays
Gloria
G
Conly
John
J
D000416:Alberta / Q000453:epidemiology; D017714:Community-Acquired Infections / Q000453:epidemiology; D004196:Disease Outbreaks; D006703:Ill-Housed Persons; D006801:Humans; D016106:Methicillin Resistance; D011329:Prisoners; D018570:Risk Assessment; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000635:transmission; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D019966:Substance-Related Disorders