Use of antiandrogens as therapy for women with polycystic ovary syndrome.
Because androgen excess plays a fundamental role in symptoms and, it is likely, in pathogenesis of polycystic ovary syndrome, attenuation of hyperandrogenism appears to be of paramount importance in the therapy of this condition. Consistently, drugs inhibiting androgen receptor binding not only are an effective tool in hirsutism treatment but also show favorable effects on body composition and metabolic features of these women.
Moghetti
Paolo
P
Endocrinology and Metabolic Diseases, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy. moghetti@iol.it
D000328:Adult; D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005485:Flutamide / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy* / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications*
D000726:Androgen Antagonists; D005485:Flutamide