title: Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose-fed rats.
abstract: The effects of DAG oil and TAG oil on impaired glucose tolerance in rats that were fed a diet containing high levels of sucrose were compared. Male Wistar rats (8 wk old and 32 wk old) were fed either high-sucrose (57.5% sucrose w/w) or control diets containing either 10% (w/w) DAG or TAG oil with a similar FA composition for 48 wk in 8-wk-old rats and for 24 wk in 32-wk-old rats. Plasma lipids, the size of the islets of Langerhans, and insulin, glucose, and adipocytokine levels were measured. An oral glucose tolerance test (OGTT) was carried out during the study period. For rats in both age groups that were fed a high-sucrose diet, the DAG oil group had lower plasma glucose and insulin response in an OGTT, and lower homeostasis model assessment-R levels, than the TAG oil group. Furthermore, in 8-wk-old rats that were fed a high-sucrose diet, the DAG oil group accumulated less visceral fat and showed suppressed decreases [corrected] of plasma adiponectin and [corrected] increases of plasma insulin, leptin, and the size of islet of Langerhans compared with the TAG oil group. No difference in the OGTT was found between the DAG and TAG oil groups in either age group of rats fed a control diet. In conclusion, these results suggest that DAG oil ingestion prevents the high-sucrose-diet-induced development of impaired glucose tolerance compared with TAG oil ingestion.
authors.affiliation: Biological Science Laboratories, Kao Corporation, Tochigi, Japan. meguro.shinichi@kao.co.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Meguro
authors.forename: Noriko
authors.initials: N
authors.lastname: Osaki
authors.forename: Noboru
authors.initials: N
authors.lastname: Matsuo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tokimitsu
mesh_terms: D050153:Abdominal Fat; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D019422:Dietary Sucrose / Q000009:adverse effects*; D004075:Diglycerides / Q000494:pharmacology*; D002149:Energy Intake / Q000187:drug effects; D018149:Glucose Intolerance / Q000139:chemically induced / Q000517:prevention & control*; D005951:Glucose Tolerance Test; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D009821:Oils; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000494:pharmacology; D014781:Viscera / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: C011439:1,2-diacylglycerol; D016207:Cytokines; D019422:Dietary Sucrose; D004075:Diglycerides; D008055:Lipids; D009821:Oils; D014280:Triglycerides