title: Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli.
abstract: Escherichia coli DNA polymerase IV incorporated 2-hydroxy-dATP opposite template guanine or thymine and 8-hydroxy-dGTP exclusively opposite adenine in vitro. Mutator phenotypes in sod/fur strains were substantially diminished by deletion of dinB and/or umuDC. DNA polymerases IV and V may be involved in mutagenesis caused by incorporation of the oxidized deoxynucleoside triphosphates.
authors.affiliation: Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Yamada
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nunoshiba
authors.forename: Masatomi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Petr
authors.initials: P
authors.lastname: Gruz
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kamiya
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Harashima
authors.forename: Takehiko
authors.initials: T
authors.lastname: Nohmi
mesh_terms: D019951:DNA Polymerase beta / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D016296:Mutagenesis; D009711:Nucleotides / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D009711:Nucleotides; D019951:DNA Polymerase beta