title: Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms.
abstract: BACKGROUND
  The prevalence and severity of chronic cough in the community is uncertain. In a large population of representative normal subjects, we explored the relationship between self-reported cough severity and frequency, and factors known to be related to the aetiology of chronic cough. In particular, we have examined the relative association between cough and symptoms of gastrointestinal disease.
  
  
  METHODS
  A cross-sectional survey was undertaken in 36 general practices with subjects randomly selected from practice computer databases. Baseline lifestyle and demographic characteristics were recorded. Participants were asked how often in the previous 2 months they had experienced bouts or spasms of coughing. Cough symptom status was dichotomised into symptomatic using a cut off of bouts or spasms of coughing at a frequency of between once a week and once a day or above. Gastrointestinal data were collected using validated methodology.
  
  
  RESULTS
  Questionnaires were sent to 6416 subjects and 4003 (62%) responded. The prevalence of chronic cough was 12%, and was severe in 7%. Following multivariate analysis, regurgitation (OR 1.71; 99% CI 1.20 to 2.45) and irritable bowel syndrome (OR 2.00; 99% CI 1.47 to 2.72) were strong predictors of cough. Smoking (OR 1.61; 99% CI 1.18 to 2.19), declining social class (OR 1.63; 99% CI 1.04 to 2.57), and quality of life at baseline (OR 1.63; 99% CI 1.13 to 2.35) were also significantly associated.
  
  
  CONCLUSIONS
  Chronic cough is a common symptom in the general population. Its strong association with gastrointestinal disease may have aetiological significance.
authors.affiliation: Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Ford
authors.forename: D
authors.initials: D
authors.lastname: Forman
authors.forename: P
authors.initials: P
authors.lastname: Moayyedi
authors.forename: A H
authors.initials: AH
authors.lastname: Morice
mesh_terms: D000328:Adult; D003371:Cough / Q000453:epidemiology / Q000209:etiology*; D004739:England / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires