title: Changes in pulmonary venous Doppler parameters in fetal cardiac defects.
abstract: OBJECTIVE
  Recent observations in pediatric cardiological studies have prompted discussion on the possible role of intrauterine pulmonary venous changes in neonatal and postoperative outcome of infants with congenital heart defects. This study analyzes changes of Doppler blood flow velocity waveforms in the pulmonary veins of fetuses with different cardiac defects.
  
  
  METHODS
  Eighty fetuses (mean gestational age, 27 weeks) with prenatally diagnosed cardiac defects were classified into one of five groups: obstructed left atrium, other left ventricular outflow tract obstruction, right ventricular outflow tract obstruction, miscellaneous cardiac defects and total anomalous pulmonary venous drainage. Doppler examination of the pulmonary veins was performed and the time velocity integral (TVI), end-diastolic (A) velocity, and pulsatility index for veins (PIV) were compared with reference ranges.
  
  
  RESULTS
  Fetuses with infradiaphragmatic total anomalous pulmonary venous drainage showed a continuous Doppler flow pattern instead of the typical pulsatile waveform pattern. In fetuses with obstructed left atrium and restrictive foramen ovale, a reversed A-velocity and increased PIV were found. In five of the eight fetuses with left outflow tract obstruction but patent mitral valve, PIV was increased. In the other groups there were no obvious changes in Doppler parameters.
  
  
  CONCLUSIONS
  We suggest routine examination of the pulmonary veins with pulsed Doppler ultrasound in every fetus with a prenatally diagnosed heart defect. Such Doppler parameters could be used in future as cut-offs for the recently reported in-utero atrial septostomy to decompress an obstructed left atrium.
authors.affiliation: Unit of Prenatal Diagnosis and Therapy, Charité University Hospital CCM, Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Lenz
authors.forename: R
authors.initials: R
authors.lastname: Chaoui
mesh_terms: D001783:Blood Flow Velocity; D018618:Echocardiography, Doppler, Color; D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D011247:Pregnancy; D011667:Pulmonary Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011673:Pulsatile Flow; D016216:Ultrasonography, Prenatal