title: Modified secoiridoid from Acicarpha tribuloides and inhibition of nitric oxide production in LPS-activated macrophages.
abstract: Bioassay-guided fractionation of Acicarpha tribuloides Juss. resulted in the isolation of an uncommon non-glycosylated secoiridoid, tribulolide (1), two known secoiridoid glycosides named secologanic acid (2) and vogeloside (3) as well as two natural chromones, 6,7-dimethoxychromone (4) and 7-hydroxy-6-methoxy-chromone (5). Compounds 1-3 showed inhibition of nitric oxide production in lipopolysaccharide-activated macrophages; their activity is comparable to that of aminoguanidine, a classic inhibitor.
authors.affiliation: Departamento de Química Orgánica (IMBIV-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Pabellón de Ciencias II, Ciudad Universitaria, Córdoba, Argentina.
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Meragelman
authors.forename: Beatriz Salido
authors.initials: BS
authors.lastname: Renteria
authors.forename: Gloria L
authors.initials: GL
authors.lastname: Silva
authors.forename: Claudia
authors.initials: C
authors.lastname: Sotomayor
authors.forename: Roberto R
authors.initials: RR
authors.lastname: Gil
mesh_terms: D000818:Animals; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D051381:Rats
chemical_list: D039823:Iridoids; D008070:Lipopolysaccharides; D009569:Nitric Oxide