title: Fluorescent measurement in the non-invasive contact lens glucose sensor.
abstract: BACKGROUND
  The purpose of the present study was to determine the effectiveness of software in the hand-held photofluorometer permitting the monitoring of a second fluorescent signal to improve a contact lens glucose sensor for the non-invasive monitoring of glucose.
  
  
  METHODS
  One fasting normal patient was given an oral challenge consisting of 75 mL of Sustacol (Thomson Micromedex, Greenwood, CO). The two contact lens fluorescent signals and fingerstick blood glucose were measured over a 3-h period.
  
  
  RESULTS
  Subtracting the second fluorescent signal from the main signal produced a product that appeared to track blood glucose well. The contact lens was comfortable and well tolerated.
  
  
  CONCLUSIONS
  The biwavelength contact lens glucose sensor shows promise as a non-invasive home glucose monitor.
authors.affiliation: Department of Ophthalmology, Downstate Medical Center, State University of New York, Brooklyn, New York 11203-2098, USA. WFMarch47@aol.com
authors.forename: Wayne
authors.initials: W
authors.lastname: March
authors.forename: Douglas
authors.initials: D
authors.lastname: Lazzaro
authors.forename: Shobit
authors.initials: S
authors.lastname: Rastogi
mesh_terms: D003208:Concanavalin A; D003261:Contact Lenses; D003911:Dextrans; D005260:Female; D005452:Fluoresceins; D005947:Glucose / Q000032:analysis*; D006801:Humans; D020100:Hydrogels; D007908:Lens, Crystalline / Q000737:chemistry*; D008991:Monitoring, Physiologic / Q000379:methods; D013050:Spectrometry, Fluorescence
chemical_list: D003911:Dextrans; D005452:Fluoresceins; D020100:Hydrogels; C052526:fluorescein-dextran; D003208:Concanavalin A; D005947:Glucose