Capecitabine-induced cerebellar toxicity.
Capecitabine is an oral prodrug of 5-fluorouracil used in the treatment of adenocarcinoma of the colon. Neurotoxicity is an infrequently reported toxicity of capecitabine. We report a case of cerebellar ataxia secondary to capecitabine therapy.
Renouf
Daniel
D
Department of Medicine, University of British Columbia.
Gill
Sharlene
S
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000069287:Capecitabine; D002430:Cecal Neoplasms / Q000188:drug therapy; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D002531:Cerebellum / Q000187:drug effects; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008297:Male
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil