Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater, part 1: development of the model.
The purpose of this study was to develop a model to predict (1) air and product temperatures, (2) product moisture, and (3) air humidity during an aqueous coating process using a Bohle Lab-Coater. Because of the geometrical properties and the airflow, the drum of the Bohle Lab-Coater can in principle be divided into 2 zones of equal size-the drying and the spraying zones. For each zone, 4 balance equations could be set up describing the change of the air humidity, the product moisture, the enthalpy of the air, and the enthalpy of the product in each zone. For this purpose, knowledge regarding heat and mass transfer and also the motion of the tablets in drums was used. Based on the considerations of the heat and mass transfer, a set of first-order coupled ordinary differential equations (ODEs) was developed. This set of ODEs can be solved numerically. In this part, the development of the model is described in detail, whereas the application of the model can be found in part 2.
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Susanne
S
Martin-Luther-University Halle-Wittenberg, Institute of Pharmaceutics and Biopharmaceutics,Wolfgang-Langenbeck-Str 4, D-06120 Halle, Germany.
Baumann
Karl-Heinrich
KH
Kleinebudde
Peter
P
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017076:Computer-Aided Design; D004339:Drug Compounding; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006813:Humidity; D008567:Membranes, Artificial; D008956:Models, Chemical; D013499:Surface Properties; D013608:Tablets, Enteric-Coated / Q000032:analysis* / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D013608:Tablets, Enteric-Coated; D014867:Water