Hosting the severe acute respiratory syndrome coronavirus: specific cell factors required for infection.
As with all viruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) utilizes specific host cell factors during its infection cycle. Some of these factors have been identified and are now increasingly scrutinized as targets to intervene with infection. In this brief review, we describe the current understanding of how the SARS-CoV is able to use the cellular machinery for its replication.
de Haan
Cornelis A M
CA
Division Virology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, the Netherlands. C.a.m.dehaan@vet.uu.nl
Rottier
Peter J M
PJ
D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D008954:Models, Biological; D012367:RNA, Viral / Q000096:biosynthesis; D045473:Severe acute respiratory syndrome-related coronavirus / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology; D045169:Severe Acute Respiratory Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000821:virology; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000502:physiology; D019065:Virus Assembly; D014779:Virus Replication / Q000502:physiology
D008562:Membrane Glycoproteins; D012367:RNA, Viral; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins