title: Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis.
abstract: A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 microM and also showed antibacterial activity against Escherichia coli and S. aureus.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-600, Republic of Korea.
authors.forename: Jung-Sung
authors.initials: JS
authors.lastname: Yoo
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Sangku
authors.initials: S
authors.lastname: Lee
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry* / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D011480:Protease Inhibitors; C514079:macrolactin N; D000581:Amidohydrolases; C084507:peptide deformylase