title: Mycobacterium avium complex with a distinct clinical and iconographic presentation: the Lady Windermere syndrome.
abstract: Clinically significant pulmonary disease caused by non-tuberculous mycobacteria such as Mycobacterium avium Complex (MAC) usually occurs upon pre-existing lung diseases or immune-deficiency. In 1992, a particular presentation of pulmonary MAC, occuring in otherwise healthy middle-aged women, was described with pulmonary consolidations localized in lingula and middle lobe. For this specific, rare condition, the term Lady Windermere syndrome was introduced. We report a particular case of this syndrome, in which an otherwise healthy individual developed clinically significant disease upon MAC (subtype: Mycobacterium avium) infection of the right middle lobe and lingula of the lung. The patient did not have the classical risk factors for developing this syndrome (e.g. habitual cough suppression, long and narrow bronchi) indicating their modest contribution in the pathogenesis. In our case, guideline based therapy was found to be inadequate because of multi-drug resistance, so an alternative treatment regime was given with good clinical result.
authors.affiliation: Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185 9000 Ghent, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Goeminne
authors.forename: R A
authors.initials: RA
authors.lastname: Peleman
authors.forename: G
authors.initials: G
authors.lastname: Brusselle
authors.forename: K G
authors.initials: KG
authors.lastname: Tournoy
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008875:Middle Aged; D008878:Middle Lobe Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D015269:Mycobacterium avium Complex / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy; D013902:Radiography, Thoracic; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000995:Antitubercular Agents; D018942:Macrolides