IdeR in mycobacteria: from target recognition to physiological function.
In mycobacteria, iron dependent transcription regulator (IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.
Ranjan
Sarita
S
Sun Centre of Excellence in Medical Bioinformatics, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.
Yellaboina
Sailu
S
Ranjan
Akash
A
D001426:Bacterial Proteins / Q000378:metabolism / Q000502:physiology*; D007501:Iron / Q000378:metabolism; D008958:Models, Molecular; D009161:Mycobacterium / Q000378:metabolism / Q000502:physiology*; D011487:Protein Conformation; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*
D001426:Bacterial Proteins; C096348:IdeR protein, Mycobacterium tuberculosis; D012097:Repressor Proteins; D007501:Iron