title: [Botulinum toxin and chronic anal fissure].
abstract: Lateral internal sphincterotomy is widely used in the treatment of chronic anal fissure. However, it is associated with a high rate of irreversible incontinence. For this reason the botulinum toxin has become a medical means of reversible sphincterotomy. Indeed, this neurotoxin induces relaxation of the smooth internal anal sphincter lasting one to three months after one injection. We reviewed the published studies about the use of this technique in the management of chronic anal fissure. Healing occurred in more than 70% of fissures without irreversible incontinence. Although further studies are needed to determine the best modalities of administration, especially due to the remaining significant recurrence rate, this toxin may be a valuable treatment for chronic anal fissure in the future.
authors.affiliation: Service de Proctologie Médico-Interventionnelle, Groupe hospitalier Diaconesses, Croix Saint Simon, Paris.
authors.forename: Fady
authors.initials: F
authors.lastname: Daniel
authors.forename: Vincent
authors.initials: V
authors.lastname: de Parades
authors.forename: Laurent
authors.initials: L
authors.lastname: Siproudhis
authors.forename: Patrick
authors.initials: P
authors.lastname: Atienza
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002908:Chronic Disease; D005401:Fissure in Ano / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009465:Neuromuscular Agents / Q000627:therapeutic use*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A