[The clinicobiological status of patients with pulmonary tuberculosis concurrent with chronic hepatitis B and/or C].
Examination was made in 155 patients, including 60 patients were diagnosed as having hepatitis, hepatic lesion being first detected by a screening survey for markers of hepatitis. The antipyrine test was carried out. Patients with slow and rapid hydroxylation were identified. No changes were found in the biotransformation functions of the liver in patients with pulmonary tuberculosis 6 months after intravenous intermittent chemotherapy twice a week from the beginning of therapy; however, there was inhibition of the activity of monooxygenases and a two-fold increase in the number of patients with slow hydroxylation among patients with concomitant chronic hepatitis B and/or C. The best results of chemotherapy were found in tuberculous patients with slow hydroxylation: they less frequently underwent surgical interventions since decay cavities were therapeutically closed.
Petrenko
T I
TI
Krasnov
V A
VA
Kharlamova
Iu M
IuM
Filimonov
P N
PN
Kizilova
N S
NS
Khudiakova
T A
TA
D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D005500:Follow-Up Studies; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D006900:Hydroxylation; D008099:Liver / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D000637:Transaminases / Q000097:blood*; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000150:complications; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D000637:Transaminases