title: Enhanced capacity of epilepsy in brain malformation produced during early development.
abstract: This study investigates the clinical features of epilepsy in 20 patients with brain malformation. Epileptic seizures were recognized in 15 patients, 12 of whom had their first seizure by 1 year of age. Partial seizure was the initial seizure type in 10 patients. Epileptic seizures were controlled in only four patients. Patients with holoprosencephaly and lissencephaly had seizure onset by 3 months of age, resulting in the most severe neurologic outcome. Only two patients with porencephaly had epileptic seizures, and in one of those patients the seizures were well controlled. A wide variety of clinical features of epilepsy in patients with brain malformation was found. More immature anomalous brain lesions may be associated with an enhanced capacity of epilepsy and resultant refractory seizures.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan. tmyktkn@belle.shiga-med.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takano
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Sokoda
authors.forename: Shie
authors.initials: S
authors.lastname: Akahori
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sakaue
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sawai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohno
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009421:Nervous System Malformations / Q000473:pathology