Apoptotic and free radical scavenging properties of the methanolic extract of Gentianella alborosea.
Gentianella alborosea ("Hercampure") is a Peruvian species used in folk medicine for the treatment of a variety of health disorders. We tested the free radical scavenging (DPPH) and induction of apoptosis on a human uterus tumor cell line (HeLa) by its methanolic extract. The results showed a noticeable radical scavenging activity and a dose-dependent apoptotic effect.
Acero
Nuria
N
Facultad de Farmacia, Universidad San Pablo CEU, Urbanización Montepríncipe, Boadilla del Monte 28660 Madrid, Spain. nacemes@ceu.es
Llinares
Francisco
F
Galán de Mera
Antonio
A
Oltra
Beatriz
B
Muñoz-Mingarro
Dolores
D
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031313:Gentianella; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008519:Medicine, Traditional; D010568:Peru; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl