Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
The synthesis of a red-shifted cy3B-GM ligand and its evaluation as a fluorescence polarization probe for Hsp90 is presented.
Moulick
Kamalika
K
Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Clement
Cristina C
CC
Aguirre
Julia
J
Kim
Joungnam
J
Kang
Yanlong
Y
Felts
Sara
S
Chiosis
Gabriela
G
D016227:Benzoquinones / Q000737:chemistry*; D002232:Carbocyanines / Q000138:chemical synthesis / Q000737:chemistry*; D003116:Color; D005454:Fluorescence Polarization; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry* / Q000145:classification; D047029:Lactams, Macrocyclic / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D017828:Rifabutin / Q000737:chemistry*
D016227:Benzoquinones; D002232:Carbocyanines; D005456:Fluorescent Dyes; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D008024:Ligands; C089187:cyanine dye 3; D017828:Rifabutin; C001277:geldanamycin