A practical and green approach toward synthesis of N3-substituted dihydropyrimidinones: using Aza-Michael addition reaction catalyzed by KF/Al2O3.
A simple and efficient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones by aza-Michael addition reactions of 3,4-dihydropyrimidinones to alpha,beta-ethylenic compounds catalyzed by KF/Al(2)O(3) is described. The advantage of this method is high regioselectivity, high purity, and the use of a cheaper, milder, and efficient catalyst for the hetero-Michael addition reaction.
Wang
Xicun
X
Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, PR China. wangxicun@nwnu.edu.cn
Quan
Zhengjun
Z
Wang
Jun-Ke
JK
Zhang
Zhang
Z
Wang
Mangang
M
D000537:Aluminum Oxide / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D017680:Potassium Compounds / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*
D001372:Aza Compounds; D005030:Ethylenes; D017680:Potassium Compounds; D011744:Pyrimidinones; D006859:Hydrogen; C033320:potassium fluoride; C036216:ethylene; D000537:Aluminum Oxide; D005459:Fluorides