title: The effect of EDTA in attachment gain and root coverage.
abstract: Root surface biomodification using low pH agents such as citric acid and tetracycline has been proposed to enhance root coverage following connective tissue grafting. The authors hypothesized that root conditioning with neutral pH edetic acid would improve vertical recession depth, root surface coverage, pocket depth, and clinical attachment levels. Twenty teeth in 10 patients with Miller class I and II recession were treated with connective tissue grafting. The experimental sites received 24% edetic acid in sterile distilled water applied to the root surface for 2 minutes before grafting. Controls were pretreated with only sterile distilled water. Measurements were evaluated before surgery and 6 months after surgery. Analysis of variance was used to determine differences between experimental and control groups. We found significant postoperative improvements in vertical recession depth, root surface coverage, and clinical attachment levels in test and control groups, compared to postoperative data. Pocket depth differences were not significant (P<.01).
authors.affiliation: Department of Surgical Sciences, Division of Periodontics, Marquette University School of Dentistry, Milwaukee, Wisconsin, USA.
authors.forename: Moawia M
authors.initials: MM
authors.lastname: Kassab
authors.forename: Robert E
authors.initials: RE
authors.lastname: Cohen
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Andreana
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Dentino
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003238:Connective Tissue / Q000637:transplantation*; D004492:Edetic Acid / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005881:Gingiva / Q000601:surgery*; D005889:Gingival Recession / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D016369:Smear Layer; D014092:Tooth Root / Q000187:drug effects*
chemical_list: D004492:Edetic Acid