title: Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia.
abstract: Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophrenia. Mismatch negativities elicited by change in tone duration and phoneme duration were recorded in 23 schizophrenia patients, who were also evaluated for auditory verbal memory and executive function. Lower amplitude of mismatch negativity under the phoneme-duration condition was significantly associated with worse verbal memory. Phoneme-duration mismatch negativity was not correlated with executive function, nor was tone-duration mismatch negativity correlated with verbal memory. These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. yukik-tky@umin.ac.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawakubo
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Noriko
authors.initials: N
authors.lastname: Kudo
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nakagome
authors.forename: Kenji
authors.initials: K
authors.lastname: Itoh
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000328:Adult; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D009483:Neuropsychological Tests; D010700:Phonetics; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000150:complications; D012565:Schizophrenic Psychology; D014706:Verbal Learning / Q000502:physiology*