title: [Venous endothelial dysfunction in Chagas' disease patients without heart failure].
abstract: OBJECTIVE
  To analyze the venous endothelial function in Chagas' disease patients without heart failure.
  
  
  METHODS
  The Chagas' disease Group (G1) was composed by 14 women and 2 men aged 46 +/- 2.7 and the Control Group (G0) by 7 women and 1 man matched by age, weight and height. Dorsal Hand Vein Compliance Technique was used to evaluate the venous endothelial function. Crescent doses of phenylephrine were infused to get a 70% pre-constriction of the vein; after that, acetylcholine and sodium nitroprusside were respectively administrated to analyze the endothelium-dependent and -independent venodilation.
  
  
  RESULTS
  No significant systemic hemodynamic changes were observed in both groups during the experiment. The necessary phenylephrine dose to reach 70% pre-constriction of the vein was significantly higher in the G1 (1116 +/- 668.2 ng/ml) compared to G0 (103 +/- 28 ng/ml) p = 0.05. The endothelium-dependent venous dilation was significantly lower in G1 (65.5 +/- 8%) compared to G0 (137 +/- 20%) p = 0.009. No difference was observed in the endothelium-independent venous dilatation between groups.
  
  
  CONCLUSIONS
  Patients with Chagas' disease without heart failure presented venous endothelial dysfunction.
authors.affiliation: Universidade Federal de São Paulo, Instituto do Coração, Hospital das Clínicas, FMUSP, São Paulo, SP. roplentz@yahoo.com.br
authors.forename: Rodrigo Della Méa
authors.initials: RD
authors.lastname: Plentz
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Andreia Simone
authors.initials: AS
authors.lastname: Muller
authors.forename: Dulce Elena
authors.initials: DE
authors.lastname: Casarini
authors.forename: Marcelo Custodio
authors.initials: MC
authors.lastname: Rubira
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno Junior
authors.forename: Charles
authors.initials: C
authors.lastname: Mady
authors.forename: Bárbara Maria
authors.initials: BM
authors.lastname: Ianni
authors.forename: Eduardo Moacir
authors.initials: EM
authors.lastname: Krieger
authors.forename: Fernanda
authors.initials: F
authors.lastname: Consolim-Colombo
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine; D000109:Acetylcholine