title: Effects of electroconvulsive seizures on Na(+),K(+)-ATPase activity in the rat hippocampus.
abstract: Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na(+),K(+)-ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40-50% of brain ATP. This work was performed in order to determine Na(+),K(+)-ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na(+),K(+)-ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na(+),K(+)-ATPase activity is altered by ECS.
authors.affiliation: Laboratório de Bioquímica Experimental, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil. emilio@unesc.net
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Streck
authors.forename: Gustavo
authors.initials: G
authors.lastname: Feier
authors.forename: Márcio
authors.initials: M
authors.lastname: Búrigo
authors.forename: Renata
authors.initials: R
authors.lastname: Franzon
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Angela T S
authors.initials: AT
authors.lastname: Wyse
mesh_terms: D000818:Animals; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D006624:Hippocampus / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase