Improving nanoprobes using surface-enhanced Raman scattering from 30-nm hollow gold particles.
We report the development of nanoprobes that exploit the surface-enhanced Raman scattering (SERS) from nonaggregated, hollow, gold nanospheres (HGNSs). The homogeneity of the HGNSs leads to a nearly 10-fold improvement in signal consistency over standard silver SERS substrates, which translates into a significant increase in sensitivity and dynamic range for the model application of pH sensing. Moreover, the small size (30-nm diameter) of these SERS-active nanoparticles represents a major step in advancing sensing technology based on SERS, making this technology more amenable to intracellular sensing.
Schwartzberg
Adam M
AM
Department of Chemistry and Biochemistry, University of California at Santa Cruz, Santa Cruz, California 95064, USA.
Oshiro
Tammy Y
TY
Zhang
Jin Z
JZ
Huser
Thomas
T
Talley
Chad E
CE
D015342:DNA Probes; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D013059:Spectrum Analysis, Raman / Q000379:methods*
D015342:DNA Probes; D006046:Gold