title: Validation of the European Prognostic Index for younger adult patients with acute myeloid leukaemia in first relapse.
abstract: In order to validate the European Prognostic Index (EPI) for patients <or=60 years with acute myeloid leukaemia in first relapse, a cohort of 599 such patients, treated between 1980 and 2004 at the MD Anderson Cancer Center, were assessed using this prognostic index. Three risk groups were defined: favourable, 76 patients (13%) [Overall survival (OS), 64% at 1 year, 22% at 5 years]; intermediate, 137 patients (23%) (OS, 38% at 1 year, 12% at 5 years); and poor, 386 patients (64%) (OS, 17% at 1 year 6% at 5 years). The EPI is reproducible and useful.
authors.affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, 77230-1402, USA. frankgiles@aol.com
authors.forename: Francis
authors.initials: F
authors.lastname: Giles
authors.forename: Srdan
authors.initials: S
authors.lastname: Verstovsek
authors.forename: Guillermo
authors.initials: G
authors.lastname: Garcia-Manero
authors.forename: Deborah
authors.initials: D
authors.lastname: Thomas
authors.forename: Farhad
authors.initials: F
authors.lastname: Ravandi
authors.forename: William
authors.initials: W
authors.lastname: Wierda
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ferrajoli
authors.forename: Steve
authors.initials: S
authors.lastname: Kornblau
authors.forename: Elias
authors.initials: E
authors.lastname: Jabbour
authors.forename: Jianqin
authors.initials: J
authors.lastname: Shan
authors.forename: Susan
authors.initials: S
authors.lastname: O'brien
authors.forename: Maher
authors.initials: M
authors.lastname: Albitar
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
mesh_terms: D000208:Acute Disease; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012306:Risk; D015996:Survival Rate