title: [Reduction of corneal permeability in patients treated with HP-guar: a fluorophotometric study].
abstract: BACKGROUND
  The incidence of dry eye disease, which mainly affects the corneal epithelium, is rising. The main treatment is still the use of artificial tears capable of improving the humidification and lubrication of the corneal epithelium, and avoiding its progressive functional failure. HP-Guar is a new compound used for this purpose.
  
  
  METHODS
  We performed a prospective, masked and paired study on the left eye of 10 patients suffering from dry eye disease. Corneal permeability measurements were performed by fluorophotometry after instilling 40 microL of a solution of 2% sodium fluorescein, before and after treatment with the HP-Guar drops. The results were analysed using Wilcoxon test for paired data.
  
  
  RESULTS
  A mean decrease in corneal permeability of 45%, after the use of HP-Guar drops was found (p=0.002).
  
  
  CONCLUSIONS
  HP-Guar provides a new therapeutic option significantly decreasing corneal epithelial permeability.
authors.affiliation: Hospital Universitario Clínico San Carlos, Universidad Complutense, Madrid, España. icervan@yahoo.com
authors.forename: I
authors.initials: I
authors.lastname: Cerván-López
authors.forename: F
authors.initials: F
authors.lastname: Sáenz-Francés-San-Baldomero
authors.forename: J M
authors.initials: JM
authors.lastname: Benítez-Del-Castillo
authors.forename: J
authors.initials: J
authors.lastname: García-Sánchez
mesh_terms: D003315:Cornea / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000378:metabolism; D019573:Epithelium, Corneal / Q000378:metabolism*; D015590:Fluorophotometry; D006801:Humans; D009883:Ophthalmic Solutions; D010539:Permeability; D011446:Prospective Studies
chemical_list: D009883:Ophthalmic Solutions