Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis.
Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with nondetectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.
Gammon
Marilie D
MD
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599-7435, USA. gammon@unc.edu
Sagiv
Sharon K
SK
Eng
Sybil M
SM
Shantakumar
Sumitra
S
Gaudet
Mia M
MM
Teitelbaum
Susan L
SL
Britton
Julie A
JA
Terry
Mary Beth
MB
Wang
Lian Wen
LW
Wang
Qiao
Q
Stellman
Steve D
SD
Beyea
Jan
J
Hatch
Maureen
M
Kabat
Geoffrey C
GC
Wolff
Mary S
MS
Levin
Bruce
B
Neugut
Alfred I
AI
Santella
Regina M
RM
D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D018736:DNA Adducts; D004198:Disease Susceptibility; D004781:Environmental Exposure / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011159:Population Surveillance; D018570:Risk Assessment; D012307:Risk Factors
D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons