Bioavailability of glucosyl hesperidin in rats.
Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.
Yamada
Mika
M
Hayashibara Biochemical Laboratories, Inc., Okayama. kaihatsu@hayashibara.co.jp
Tanabe
Fujimi
F
Arai
Norie
N
Mitsuzumi
Hitoshi
H
Miwa
Yoshikatsu
Y
Kubota
Michio
M
Chaen
Hiroto
H
Kibata
Masayoshi
M
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002432:Cecum / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D020723:Glucuronic Acid / Q000097:blood; D006569:Hesperidin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D006868:Hydrolysis; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley
D005960:Glucosides; C487382:glucosyl hesperidin; D020723:Glucuronic Acid; D006569:Hesperidin