[Study on the correlation between coronary heart disease and chronic periodontitis].
OBJECTIVE
To explore the correlation between angiographically-defined coronary heart disease (CHD) and chronic periodontitis (CP).


METHODS
277 cases with CHD (case group) and another 238 with no agiographic evidence of CHD (control group) were compared on their traditional cardiovascular risk factors, as: oral health status and probing depth, clinical attachment level, gingival recession, as well as number of missing teeth. Other related risk factors of CHD were included in a stepwise logistic regression analysis.


RESULTS
Data from univariate analysis showed that there was significant difference in CP, plasma triglyceride, high density lipoprotein cholesterol (HDL-C), fast glucose, white blood count, hypertension and smoking between patients with CHD and those with out CHD (P < 0.01 - 0.001). Multiple factorial logistic regression analysis showed that CP, hypertension, diabetes mellitus, HDL-C were strongly correlated with the incidence of CHD. Significant dosage-effective response was also found in the relationship between CP and CHD (P < 0.001). Further studies also suggested that the severity of CP paralleled the severity of CHD.


CONCLUSIONS
The results indicated that CP might serve as an independent risk factor of CHD and significantly enhance the risk and severity of CHD. Our study suggested that the elimination of probable risk factors in oral cavity was indispensable during the process of the prevention of CHD in order to prevent acute coronary events.
Zhang
Yuan-ming
YM
Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Zhong
Liang-jun
LJ
He
Bing-xian
BX
Nie
Jing
J
Wang
Xuan
X
Li
Wen-chao
WC
D000792:Angiography; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D003327:Coronary Disease / Q000453:epidemiology*; D006801:Humans; D009909:Oral Health; D010518:Periodontitis / Q000453:epidemiology*; D012307:Risk Factors
D015415:Biomarkers