Inflammatory pseudotumor involving the skull base: response to steroid and radiation therapy.
OBJECTIVE
To evaluate the response to steroid and radiation therapy in inflammatory pseudotumor (IPT) involving the skull base.


METHODS
Eight patients with IPT of the skull base were evaluated. Six patients were diabetic. All patients underwent initial high-dose steroid therapy. Seven of 8 patients underwent subsequent low-dose steroid maintenance. Additional low-dose radiation therapy was performed in 6 patients. We reviewed the medical records and radiologic findings of the patients to evaluate their responses to the steroid and radiation therapy.


RESULTS
In all patients, the initial response to steroid therapy was fair. However, 7 patients showed symptom recurrence after cessation of steroid therapy. In 5 of 6 patients, low-dose radiation therapy resulted in recurrence. On follow-up MRI, none of the patients showed complete remission of the disease.


CONCLUSIONS
This study shows aggressive clinical behavior of IPT involving the skull base and its poor response to steroid therapy and low-dose radiation therapy. For improving control, more aggressive initial efforts including high-dose radiation therapy with or without concurrent steroid therapy might play a role.


METHODS
C-4.
Lee
Dong Kyung
DK
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul, Korea.
Cho
Yang-Sun
YS
Hong
Sung Hwa
SH
Chung
Won Ho
WH
Ahn
Yong Chan
YC
D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D016896:Treatment Outcome
D005938:Glucocorticoids; D011239:Prednisolone