title: Comparison of antitumor activities in tumor xenograft treatment.
abstract: To compare treatment effects with antitumor therapies, we proposed an intuitive approach to compare the antitumor effects of two different antitumor treatments by investigating tumor volumes which were measured in a given period of time. The approach is, in essence, a comparison of two unknown functions. The implementation of the approach is simple and straightforward. The approach is applied to analyze a real xenograft study of a new antitumor agent, irofulven, combined with irinotecan.
authors.affiliation: Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, United States. hliang@bst.rochester.edu
authors.forename: Hua
authors.initials: H
authors.lastname: Liang
mesh_terms: D000465:Algorithms; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004195:Disease Models, Animal; D006801:Humans; D000077146:Irinotecan; D051379:Mice; D012717:Sesquiterpenes / Q000008:administration & dosage*; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C102714:irofulven; D000077146:Irinotecan; D002166:Camptothecin