title: Early increases in cardiac troponin levels after major vascular surgery is associated with an increased frequency of delayed cardiac complications.
abstract: OBJECTIVE
  To evaluate changes in cardiac troponin-I levels after major vascular surgery and their association with early and late postoperative cardiac complications.
  
  
  METHODS
  Prospective, observational investigation.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  75 consecutive patients undergoing major vascular surgery.
  
  
  METHODS
  All patients received a standard sevoflurane-fentanyl anesthesia during the procedure. Blood levels of creatine kinase with MB subtype and cardiac troponin-I were assessed before surgery and then everyday for the first 3 days after surgery. At the same time, 12-lead electrocardiography was also performed, and occurrence of any cardiac adverse event was recorded. Patients were then followed up for 1 month after surgery.
  
  
  RESULTS
  Troponin-I levels increased in 25 patients (33%) during the first 3 days after surgery; 9 of these patients (12%) had myocardial infarction. At univariate analysis, uncontrolled hypertension was the only risk factor for perioperative infarction (odds ratio, 16; (95% confidence interval, 3-74); however, multivariate logistic regression analysis failed to show statistically significant associations. Increases in troponin-I had a 100% sensitivity and 75% specificity in detecting myocardial ischemia with a 36% positive and 100% negative predictive values. Severe cardiac complication 1 month after surgery was reported in 5 patients (6.6%). The increase of cardiac troponin-I levels during the first 3 postoperative days was associated with an increased frequency of major cardiac complication at 1-month follow-up (P = 0.003), with a 100% sensitivity, 71% specificity, and 100% negative predictive value.
  
  
  CONCLUSIONS
  Myocardial infarction after major noncardiac vascular surgery occurs in up to 12% of cases. Perioperative monitoring of troponin-I plasma levels may help to identify patients at increased risk for cardiac morbidity not only early after surgery but also during the first postoperative month.
authors.affiliation: Department of Anesthesia and Pain Therapy, University of Parma, 43100 Parma, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Barbagallo
authors.forename: Andrea
authors.initials: A
authors.lastname: Casati
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Spadini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bertolizio
authors.forename: Lucy
authors.initials: L
authors.lastname: Kepgang
authors.forename: Tiziano
authors.initials: T
authors.lastname: Tecchio
authors.forename: Pierfranco
authors.initials: P
authors.lastname: Salcuni
authors.forename: Angelo
authors.initials: A
authors.lastname: Rolli
authors.forename: Elisa
authors.initials: E
authors.lastname: Orlandelli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Rossini
authors.forename: Guido
authors.initials: G
authors.lastname: Fanelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009203:Myocardial Infarction / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D011183:Postoperative Complications; D011184:Postoperative Period; D011237:Predictive Value of Tests; D019210:Troponin I / Q000378:metabolism*; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D019210:Troponin I