title: Phosphonoacetic Acid inhibition of frog virus 3 replication.
abstract: Phosphonoacetic acid at concentrations above 200 mug/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or gamma polypeptides was also inhibited by phosphonoacetic acid, although the early (alpha and beta) polypeptides were unaffected.
authors.affiliation: Unit of Invertebrate Virology, Natural Environment Research Council, and Department of Forestry, University of Oxford, Oxford, OX1 3UB, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Elliott
authors.forename: A
authors.initials: A
authors.lastname: Bateson
authors.forename: D C
authors.initials: DC
authors.lastname: Kelly