title: [Abnormal expression of cCD79a/cCD22 in acute myeloid leukemia with t (8;21)].
abstract: OBJECTIVE
  To report abnormal expression of cCD79a/cCD22 in four cases of acute myeloid leukemia (AML) with t (8;21).
  
  
  METHODS
  The characteristics of morphology, immunophenotype, chromosome karyotype (MIC) and clinical manifestations of 4 AML patients with t (8;21) expressing cCD79a/cCD22 were analyzed.
  
  
  RESULTS
  The features of the 4 patients were: (1) no difference in gender; (2) young age; (3) exmedullary infiltration may be present; (4) normal number of white blood cells in peripheral blood; (5) morphology showed acute myeloid leukemia with high percentage of blast cells; (6) B-lymphoid and myeloid immunophenotype, and high expression of CD34; (7) frequent depletion of Y chromosome and complex changes of chromosomes; (8) positive for AML1/ETO fusion gene; (9) response well to chemotherapy regimen which simultaneously treated myeloid and lymphocytic leukemia.
  
  
  CONCLUSIONS
  Abnormal expression of cCD79a/cCD22 in AML with t (8;21) (q22;q22) suggested that this kind of leukemia might be related with abnormal expression gene of B cell.
authors.affiliation: First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.
authors.forename: Guang-sheng
authors.initials: GS
authors.lastname: He
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: De-pei
authors.initials: DP
authors.lastname: Wu
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Xue
authors.forename: Ming-qing
authors.initials: MQ
authors.lastname: Zhu
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Liu
authors.forename: Ai-ning
authors.initials: AN
authors.lastname: Sun
authors.forename: Zheng-ming
authors.initials: ZM
authors.lastname: Jin
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Qiu
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Tang
authors.forename: Zheng-zheng
authors.initials: ZZ
authors.lastname: Fu
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D051925:CD79 Antigens / Q000378:metabolism*; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000378:metabolism*; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: D051925:CD79 Antigens; D051918:Sialic Acid Binding Ig-like Lectin 2