[Anti PM-Scl antibodies. Study of prevalence and of meaning].
OBJECTIVE
The purpose of our study is to appreciate the prevalence of antibodies anti PM-Scl within the framework of antinuclear antibodies detection and to clarify clinical biological and evolutive features associated to these antibodies.


METHODS
9,747 consecutive antinuclear testing datas allowed us to evaluate anti PM-Scl antibodies frequency. A retrospective analysis of patients characteristics was performed to identify clinical, biological and evolutive signs associated with this antibody over a five years follow up period.


RESULTS
Over the 9,747 samples tested for antinuclear antibodies detection, 3,493 (35.8%) are positive. An anti ENA activity is observed in 727 (7.5%) cases and anti PM-Scl in 6 (0.06%). These antibodies are described in systemic sclerosis, myositis or overlap syndromes. All theses diseases showed a low evolutivity over the five years of follow up.


CONCLUSIONS
Low prevalence and possible association with an overlap autoimmune syndrome of quite good prognosis are reported with anti PM-Scl antibodies.
Gaudin
C
C
Service de Médecine Interne et Immunopathologie Clinique, Pavillon des Médecines, CHU de Toulouse-Purpan, TSA 40031, 31049 Toulouse Cedex 09, France.
Fortenfant
F
F
Adoue
D
D
Beyne-Rauzy
O
O
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens; D003882:Dermatomyositis / Q000175:diagnosis / Q000276:immunology*; D005095:Exoribonucleases; D063326:Exosome Multienzyme Ribonuclease Complex; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000276:immunology*; D017285:Polymyositis / Q000175:diagnosis / Q000276:immunology*; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D045743:Scleroderma, Diffuse / Q000175:diagnosis / Q000276:immunology*; D013997:Time Factors
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D005095:Exoribonucleases; D063326:Exosome Multienzyme Ribonuclease Complex; C077044:EXOSC10 protein, human