A woman with red eyes and hypokalemia: a case of acquired Gitelman syndrome.
Gitelman syndrome is a rare hereditary disorder of the thiazide-sensitive NaCl transporter in the distal renal tubular cells, but mimicking of such hereditary tubular disorders has been described in different autoimmune diseases (Sjögren syndrome, SLE, ...). A 62-year-old woman with painful red eyes and sicca syndrome presented at the ophthalmological department. The diagnostic evaluation identified a Sjögren syndrome with early endophthalmitis as the reason for the red eyes. Results of laboratory examination indicated severe hypokalemia, metabolic alkalosis and hypomagnesemia, although this had not been seen years earlier. Together with the urine analysis, a rare case of an acquired Gitelman syndrome was diagnosed. Substitution with potassium and magnesium improved the initial symptoms of weakness, but renal electrolyte wasting persisted even after treatment of Sjögren syndrome. In patients with autoimmune disease, laboratory analysis of serum electrolytes should be performed because different acquired tubular disorders can lead to severe hypokalemia.
Schwarz
Christoph
C
Internal Medicine III, Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria. christoph.schwarz@meduniwien.ac.at
Barisani
Talin
T
Bauer
Edith
E
Druml
Wilfred
W
D001477:Bartter Syndrome / Q000175:diagnosis*; D003231:Conjunctivitis; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis*; D007634:Keratitis / Q000175:diagnosis*; D008875:Middle Aged; D016111:Sjogren-Larsson Syndrome / Q000175:diagnosis*