Microarrays and the microscope: balancing throughput with resolution.
The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.
Coppola
Giovanni
G
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Geschwind
Daniel H
DH
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000502:physiology; D003952:Diagnostic Imaging; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000235:genetics* / Q000502:physiology; D005819:Genetic Markers; D006801:Humans; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000166:cytology / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis
D005819:Genetic Markers