JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions.
High levels of interspecies conservation characterise all signal transduction cascades and demonstrate the significance of these pathways over evolutionary time. Here, we review advances in the field of JAK/STAT signalling, focusing on recent developments in Drosophila. In particular, recent results from genetic and genome-wide RNAi screens, as well as studies into the developmental roles played by this pathway, highlight striking levels of physical and functional conservation in processes such as cellular proliferation, immune responses and stem cell maintenance. These insights underscore the value of model organisms for improving our understanding of this human disease-relevant pathway.
Arbouzova
Natalia I
NI
Department of Molecular Developmental Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Zeidler
Martin P
MP
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D053612:Janus Kinases; D050828:Protein Inhibitors of Activated STAT / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000092468:Bromodomain Containing Proteins
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053612:Janus Kinases; D050828:Protein Inhibitors of Activated STAT; D011505:Protein-Tyrosine Kinases; D050791:STAT Transcription Factors; D050826:Suppressor of Cytokine Signaling Proteins; D014157:Transcription Factors; C502037:BRWD3 protein, human; D000092468:Bromodomain Containing Proteins; C508384:Ken protein, Drosophila; C105675:Stat92E protein, Drosophila; C118811:Su(var)2-10 protein, Drosophila; C085845:hop protein, Drosophila