The role of G-CSF in adaptive immunity.
Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role as regulator of hematopoiesis and innate immune responses. There is growing evidence that G-CSF also exerts profound immunoregulatory effects in adaptive immunity. G-CSF mediates anti-inflammatory reactions accompanied by TH2 cell differentiation and promotes tolerogeneic cell populations at both poles of APC/T cell interaction. These recent findings have highlighted the novel impact of G-CSF in transplantation tolerance and autoimmunity. G-CSF represents a powerful and promising cytokine to promote T cell tolerance in pathological conditions associated with a TH1/TH2 imbalance.
Franzke
Anke
A
Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany. franzke@mh-hannover.de
D001327:Autoimmune Diseases / Q000276:immunology; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D033581:Stem Cell Transplantation; D013601:T-Lymphocytes / Q000276:immunology*
D016179:Granulocyte Colony-Stimulating Factor