title: Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review.
abstract: Renal oncocytomas are uncommon tumors of the renal collecting duct. Although generally benign, these tumors pose a diagnostic and therapeutic dilemma in that they can not be differentiated noninvasively from renal cell carcinomas. We report a 67-year-old man who underwent a clinical 1-11C acetate positron emission tomography (PET) scan for evaluation of possible metastatic prostate carcinoma. The study demonstrated a nodule at the inferior pole of the right kidney with more uptake than the remainder of the kidney. Correlation was made with MRI, which demonstrated that the nodule was solid, and enhanced after contrast agent administration. Upon resection, this nodule was determined to be an oncocytoma. To our knowledge, this marks the first report of the 1-11C acetate PET scan appearance of a renal oncocytoma Possible mechanisms for increased uptake include dysfunctional, but up-regulated oxidative phosphorylation or uptake through lipid biosynthesis pathways.
authors.affiliation: Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8223, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA. shrikij@mir.wustl.edu
authors.forename: Jabi
authors.initials: J
authors.lastname: Shriki
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Murthy
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Brown
mesh_terms: D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D002250:Carbon Radioisotopes; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography
chemical_list: D002250:Carbon Radioisotopes