title: Suppressive treatment of abamectin against Dictyocaulus viviparus and the occurrence of resistance in first-grazing-season calves.
abstract: Dictyocaulus viviparus cause severe lung infections and are endemic in some areas of temperate and tropical countries. Treatment is based on strategic nematode control programs using potent compounds with no reports of drug failure. Macrocyclic lactones (MLs) are available at different concentrations and combinations and have being used heavily by producers. The objective of this work was to determine the efficacy of the MLs ivermectin, moxidectin, doramectin, and abamectin, and the combination ivermectin plus abamectin in naturally infected calves (n=70). Initial infection was determined by necropsy of tracer animals. Faecal larval counts determined that none of the compounds used was able to eliminate D. viviparus for up to 28 days after treatment. The "Area Nova" strain was isolated for future work.
authors.affiliation: Setor de Doenças Parasitárias, Universidade Federal de Santa Maria, Santa Maria, Brazil. molento@ufpr.br
authors.forename: M B
authors.initials: MB
authors.lastname: Molento
authors.forename: R A
authors.initials: RA
authors.lastname: Depner
authors.forename: M H A
authors.initials: MH
authors.lastname: Mello
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004021:Dictyocaulus / Q000187:drug effects* / Q000254:growth & development; D004022:Dictyocaulus Infections / Q000188:drug therapy*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; C048324:abamectin; D007559:Ivermectin