A facile synthesis of 1,6-dideoxynojirimycin from L-sorbose.
A practical synthesis of 1,6-dideoxynojirimycin, a potent glycosidase inhibitor, starting from L-sorbose, is described.
An
Jia-Ning
JN
Department of Chemical Biology, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Meng
Xiang-Bao
XB
Yao
Yun
Y
Li
Zhong-Jun
ZJ
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D005959:Glucosidases / Q000037:antagonists & inhibitors; D008956:Models, Chemical; D015394:Molecular Structure; D013013:Sorbose / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
C513752:1,6-dideoxynojirimycin; D004791:Enzyme Inhibitors; D017485:1-Deoxynojirimycin; D005959:Glucosidases; D013013:Sorbose