title: Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells.
abstract: Naringenin is a naturally occurring citrus flavanone. In this study, we examined the effect of naringenin on melanogenesis in mouse B16 melanoma cells. Melanin contents and tyrosinase activities were strongly increased by naringenin. Naringenin was found to cause marked increases in the expression levels of melanogenic enzymes.
authors.affiliation: Gifu International Institute of Biotechnology. kohguchi@giib.or.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohguchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002957:Citrus / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D015394:Molecular Structure
chemical_list: D044950:Flavanones; D008543:Melanins; C005273:naringenin