An algorithmic method for reducing conductance-based neuron models.
Although conductance-based neural models provide a realistic depiction of neuronal activity, their complexity often limits effective implementation and analysis. Neuronal model reduction methods provide a means to reduce model complexity while retaining the original model's realism and relevance. Such methods, however, typically include ad hoc components that require that the modeler already be intimately familiar with the dynamics of the original model. We present an automated, algorithmic method for reducing conductance-based neuron models using the method of equivalent potentials (Kelper et al., Biol Cybern 66(5):381-387, 1992) Our results demonstrate that this algorithm is able to reduce the complexity of the original model with minimal performance loss, and requires minimal prior knowledge of the model's dynamics. Furthermore, by utilizing a cost function based on the contribution of each state variable to the total conductance of the model, the performance of the algorithm can be significantly improved.
Sorensen
Michael E
ME
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
DeWeerth
Stephen P
SP
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000465:Algorithms; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D020342:Finite Element Analysis; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology* / Q000528:radiation effects; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects