Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder.
Temporal lobe and limbic structures may be abnormal in bipolar disorder. T2-weighted magnetic resonance imaging (MRI) scans frequently show deep white matter lesions. MRI was performed on 50 young (19-39 years) euthymic patients with bipolar disorder and 26 controls. Mean temporal lobe volumes were reduced in patients (right, 9.42 cm3; left, 6.33 cm3) but this could not but this could not be ascribed to a specific structure. Deep white matter lesions were present in 5 patients but no controls raising questions of their aetiological significance.
El-Badri
Selim M
SM
Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
Cousins
David A
DA
Parker
Sean
S
Ashton
Heather C
HC
McAllister
Victor L
VL
Ferrier
I Nicol
IN
Moore
P Brian
PB
D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002508:Cephalometry; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000473:pathology