title: Prevention of asthma during the first 5 years of life: a randomized controlled trial.
abstract: BACKGROUND
  Early life exposures may be important in the development of asthma and allergic disease.
  
  
  OBJECTIVE
  To test house dust mite (HDM) avoidance and dietary fatty acid modification, implemented throughout the first 5 years of life, as interventions to prevent asthma and allergic disease.
  
  
  METHODS
  We recruited newborns with a family history of asthma antenatally and randomized them, separately, to HDM avoidance or control and to dietary modification or control. At age 5 years, they were assessed for asthma and eczema and had skin prick tests for atopy.
  
  
  RESULTS
  Of 616 children randomized, 516 (84%) were evaluated at age 5 years. The HDM avoidance intervention resulted in a 61% reduction in HDM allergen concentrations (microg/g dust) in the child's bed but no difference in the prevalence of asthma, wheeze, or atopy (P > .1). The prevalence of eczema was higher in the active HDM avoidance group (26% vs 19%; P = .06). The ratio of omega-6 to omega-3 fatty acids in plasma was lower in the active diet group (5.8 vs 7.4; P < .0001). However, the prevalence of asthma, wheezing, eczema, or atopy did not differ between the diet groups (P > .1).
  
  
  CONCLUSIONS
  Further research is required to establish whether other interventions can be recommended for the prevention of asthma and allergic disease.
  
  
  CONCLUSIONS
  House dust mite avoidance measures and dietary fatty acid modification, as implemented in this trial during infancy and early childhood, did not prevent the onset of asthma, eczema, or atopy in high-risk children.
authors.affiliation: Woolcock Institute of Medical Research, Missenden Road Post Office, New South Wales 2050, Australia. g.marks@unsw.edu.au
authors.forename: Guy B
authors.initials: GB
authors.lastname: Marks
authors.forename: Seema
authors.initials: S
authors.lastname: Mihrshahi
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Kemp
authors.forename: Euan R
authors.initials: ER
authors.lastname: Tovey
authors.forename: Karen
authors.initials: K
authors.lastname: Webb
authors.forename: Catarina
authors.initials: C
authors.lastname: Almqvist
authors.forename: Rosario D
authors.initials: RD
authors.lastname: Ampon
authors.forename: Daniel
authors.initials: D
authors.lastname: Crisafulli
authors.forename: Elena G
authors.initials: EG
authors.lastname: Belousova
authors.forename: Craig M
authors.initials: CM
authors.lastname: Mellis
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Peat
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Leeder
mesh_terms: D000818:Animals; D001249:Asthma / Q000517:prevention & control*; D002675:Child, Preschool; D004485:Eczema / Q000209:etiology; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008925:Mites / Q000276:immunology; D010349:Patient Compliance
chemical_list: D005227:Fatty Acids