title: Positional hyperventilation-induced hypoxaemia in pectus excavatum.
abstract: The presented case is of a young male (aged 19 yrs) with a pectus excavatum who showed significant exercise intolerance, despite normal pulmonary function at rest, including carbon monoxide diffusing capacity. Clinical exercise testing led to a strong suspicion of a right-to-left shunt due to an abnormally wide alveolo-arterial oxygen gradient (26.4 kPa) at peak oxygen uptake, with severe arterial hypoxaemia (arterial oxygen tension 12.54 kPa). A right-to-left shunt was confirmed by transoesophageal echocardiography demonstrating a permeable foramen ovale, despite normal right heart pressures. The right-to-left venous flow was mainly dependent on the upright body position and the deep inspiration. Indeed, i.v. dobutamine infusion to selectively affect cardiac output and hyperventilation induced by tidal volume expansion at constant breathing rate in the supine position did not result in arterial oxygen desaturation or shunting. Closure of the foramen ovale through atrial umbrella placement dramatically improved clinical and physiological abnormalities. This observation demonstrates that a hyperventilatory manoeuvre in the upright position is able to detect a permeable foramen ovale favouring flow in the inferior vena cava in the direction of the abnormal pre-existing atrial channel in a patient with a pectus excavatum.
authors.affiliation: Clinique des Maladies Respiratoires, Hôpital Albert Calmette, Boulevard du Pr. Jules Leclercq, 59037 Lille Cedex, France. bwallaert@chru-lille.fr
authors.forename: B
authors.initials: B
authors.lastname: Wallaert
authors.forename: B
authors.initials: B
authors.lastname: Cavestri
authors.forename: C
authors.initials: C
authors.lastname: Fournier
authors.forename: R
authors.initials: R
authors.lastname: Nevière
authors.forename: B
authors.initials: B
authors.lastname: Aguilaniu
mesh_terms: D000328:Adult; D017548:Echocardiography, Transesophageal; D015444:Exercise; D005080:Exercise Test; D005660:Funnel Chest / Q000175:diagnosis* / Q000473:pathology; D006346:Heart Septum; D006801:Humans; D006985:Hyperventilation / Q000150:complications* / Q000473:pathology*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D010100:Oxygen; D012129:Respiratory Function Tests
chemical_list: D010100:Oxygen