Dietary hydrogenated soybean oil affects lipid and vitamin E metabolism in rats.
Fatty acids containing stearic acid, which are found in hydrogenated fat, may have a detrimental effect on the cholesterol and triacylglycerol (TAG) content of plasma lipoproteins, and on the absorption of fatty acids and fat-soluble vitamins. The aim of our study was to examine the tissue concentration of lipids and vitamins A and E after feeding a hydrogenated soybean oil (HSO) diet to rats. Twenty male Sprague-Dawley rats were randomly divided into two groups, fed on coconut oil (control) and HSO, respectively in amounts corresponding to 15% of the total feed. Plasma total cholesterol, VLDL- and LDL-cholesterol, lipid peroxidation and daily excretion of the TAG and cholesterol in feces were higher in the HSO than in the control group. TAG values in plasma and liver, and HDL-cholesterol levels in plasma were lower in the HSO than in the control group. The same was true for phospholipids in plasma and for saturated fatty acids, mono- and polyunsaturated fatty acids levels in the liver and vitamin E in plasma, LDL and adipose tissue. The results of this study provide new evidence concerning the effect of dietary hydrogenated fat on lipid, TAG and vitamin E status, which are important for maintenance of good health. Consumption of dietary HSO may be associated with cardiovascular disease.
Naziroglu
Mustafa
M
Institute of Nutritional Sciences, Martin-Luther-University of Halle-Wittenberg, Halle/Saale, Germany. mnaziroglu@med.sdu.edu.tr
Brandsch
Corinna
C
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology*; D005243:Feces; D006865:Hydrogenation; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil / Q000378:metabolism / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
D004041:Dietary Fats; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D014801:Vitamin A; D014810:Vitamin E; D013024:Soybean Oil; D002784:Cholesterol