title: [A case of peripheral ischemic complication after terlipressin therapy].
abstract: Hepatorenal syndrome is a severe complication of cirrhosis, leading to death in more than 90% of cases in the absence of liver transplantation. Several treatments have been attempted as a bridge to liver transplantation. Among such treatments, terlipressin is a nonselective V1 vasopressin agonist. When comparing with ornipressin, it is known to have a similar vasoconstricting potency, but much less ischemic complication. We report a case of gangrene on toes and necrosis on the infusion site of left hand which developed after the use of terlipressin due to hepatorenal syndrome in a 41-year-old-man with liver cirrhosis. Ischemic complication of terlipressin is rare and there has been no case report in Korea. Although it is rare, we must pay attention to the peripheral ischemic complication of terlipressin.
authors.affiliation: Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea.
authors.forename: Jong Sup
authors.initials: JS
authors.lastname: Lee
authors.forename: Hong Sik
authors.initials: HS
authors.lastname: Lee
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Jung
authors.forename: Woo Sik
authors.initials: WS
authors.lastname: Han
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jai Hyun
authors.initials: JH
authors.lastname: Choi
authors.forename: Chang Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Ho Sang
authors.initials: HS
authors.lastname: Ryu
authors.forename: Jin Hai
authors.initials: JH
authors.lastname: Hyun
mesh_terms: D000328:Adult; D006225:Hand / Q000098:blood supply*; D006530:Hepatorenal Syndrome / Q000188:drug therapy; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D008236:Lypressin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D000077585:Terlipressin; D014034:Toes / Q000098:blood supply*; D014662:Vasoconstrictor Agents / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin