title: A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity.
abstract: A trinuclear 3N-chelated monofunctional platinum complex, [Pt3(HPTAB)Cl3](ClO4)3 (HPTAB = N,N,N',N',N'',N''-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin.
authors.affiliation: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P R China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Weijiang
authors.initials: W
authors.lastname: He
authors.forename: Pengfei
authors.initials: P
authors.lastname: Shi
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.forename: Liping
authors.initials: L
authors.lastname: Lin
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry* / Q000633:toxicity; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D017671:Platinum Compounds / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D002614:Chelating Agents; D017671:Platinum Compounds; D004247:DNA; D009584:Nitrogen