Toxicology case of the month: oral hypoglycaemic overdose.
A teenager ingests 375 mg of glipizide and 14.5 g of melformin intentionally in a small country town. She presents to the local medical facility with symptoms and signs of hypoglycaemia. Using a risk assessment based approach, the management of suiphonylurea and metformin overdose is discussed. Sulphonylurea overdose invariably results in profound hypoglycaemia that requires resuscitation with IV dextrose and the use of octreotide as an antidote. Metfonnin overdose rarely causes problems.
Soderstrom
J
J
Sir Charles Gairdner Hospital, Perth, WA, australia.
Murray
L
L
Daly
F F S
FF
Little
M
M
D000293:Adolescent; D062787:Drug Overdose; D004636:Emergency Service, Hospital / Q000458:organization & administration*; D005260:Female; D005913:Glipizide / Q000506:poisoning*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000628:therapy*; D007004:Hypoglycemic Agents / Q000506:poisoning*; D008687:Metformin / Q000506:poisoning*; D018570:Risk Assessment; D016896:Treatment Outcome; D014904:Western Australia
D007004:Hypoglycemic Agents; D008687:Metformin; D005913:Glipizide