An expedient synthesis of N6-substituted-5'-modified adenosines.
Herein we report a short and efficient synthesis of N(6)-substituted 5'-modified adenosines, which was achieved in four steps from 2',3',5'-tris-O-(tert-butyldimethylsilyl)inosine.
Ashton
T D
TD
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Vic., Australia.
Scammells
Peter J
PJ
D000241:Adenosine / Q000138:chemical synthesis / Q000737:chemistry*; D007288:Inosine / Q000737:chemistry; D015394:Molecular Structure
D007288:Inosine; D000241:Adenosine