title: SPIR MRI usefulness for steroid treatment management in Tolosa-Hunt syndrome.
abstract: A 40-year-old man underwent surgery for a right middle ear cholesteatoma. One month later, he presented with a subacute ocular pain that was followed one day later by the appearance of vertical diplopia attributable to a right superior rectus paresis, lid ptosis and hypoaesthesia in the territory of the I and the II right trigeminal branches. A fat-suppressed (selective partial inversion recovery, SPIR) gadolinium-enhanced MRI favours the detection of inflammatory pathological tissue inside the right cavernous sinus, and in this patient it suggested a diagnosis of Tolosa-Hunt syndrome. The pain disappeared quickly after steroid treatment was started whereas the ocular nerve involvement improved only slightly during the first week of treatment. After two months, the patient only complained of diplopia on up-gaze, but the therapy was discontinued two months later on the basis of both clinical signs and MRI findings. SPIR MRI may be useful not only to support a diagnosis of Tolosa-Hunt syndrome, but also to follow-up the disease course and to manage steroid treatment.
authors.affiliation: Laboratorio Movimenti Oculari, Fondazione Istituto Neurologico C. Mondino, IRCCS, Via Mondino 2, I-27100, Pavia, Italy. si.co@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Colnaghi
authors.forename: A
authors.initials: A
authors.lastname: Pichiecchio
authors.forename: S
authors.initials: S
authors.lastname: Bastianello
authors.forename: M
authors.initials: M
authors.lastname: Versino
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018424:Cholesteatoma, Middle Ear / Q000150:complications / Q000601:surgery; D019818:Clavulanic Acid / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009886:Ophthalmoplegia / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000503:physiopathology; D020333:Tolosa-Hunt Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D014657:Vasculitis / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D019818:Clavulanic Acid; D000658:Amoxicillin; D011241:Prednisone