Enantioselective synthesis of bridged- or fused-ring bicyclic ketones by a catalytic asymmetric Michael addition pathway.
Efficient methodology has been developed for the conjugate addition of ketene acetals to cyclic alpha,beta-enones. The chiral adducts allow access to fused- or bridged-ring structures such as those shown.
Liu
Duan
D
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Hong
Sungwoo
S
Corey
E J
EJ