title: [Endoresection of large uveal melanomas after pretreatment by single-dose stereotactic convergence irradiation with the leksell gamma knife--first experience on 46 cases].
abstract: BACKGROUND
  The aim of this non-comparative, consecutive case series is to evaluate the short-term results after endoresection of large uveal melanomas in combination with pretreatment with stereotactic gamma knife radiosurgery.
  
  
  METHODS
  Between March 2000 and November 2002, forty-six patients with large uveal melanomas underwent stereotactic radiosurgery followed by endoresection of the tumour via a standard three-port vitrectomy including laser photocoagulation and silicone oil tamponade. The average tumour height was 9.5 mm. The minimum dose delivered to the tumour volume was 25 Gy.
  
  
  RESULTS
  The median follow-up time was 410 days. In 40 cases (87 %), the eye was retained with a VA of 20/200 or better in 30 cases (65.2 %) and 20/63 or better in ten cases (21.7 %). In 12 eyes with a follow-up of >/= 0.5 years, the median VA was 20/80 after silicone oil removal and cataract surgery had been performed. Six eyes (13 %) were enucleated due to serious complications caused by the radiosurgery (3 cases) or endoresection (3 cases). In 13 patients (28.2 %), additional major surgery was required. Seven patients developed liver metastases during follow-up and six patients died. No local tumour recurrences were observed.
  
  
  CONCLUSIONS
  Eyes with large uveal melanomas can be salvaged by stereotactic radiotherapy followed by endoresection.
authors.affiliation: Universitäts-Augenklinik Essen. harald.schilling@uni-essen.de
authors.forename: H
authors.initials: H
authors.lastname: Schilling
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.forename: S
authors.initials: S
authors.lastname: Talies
authors.forename: G
authors.initials: G
authors.lastname: Anastassiou
authors.forename: A
authors.initials: A
authors.lastname: Schüler
authors.forename: G A
authors.initials: GA
authors.lastname: Horstmann
authors.forename: B
authors.initials: B
authors.lastname: Jurklies
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D010865:Pilot Projects; D016634:Radiosurgery / Q000379:methods*; D016879:Salvage Therapy / Q000379:methods; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000601:surgery*; D014821:Vitrectomy / Q000379:methods*