title: Acute oxidative stress is associated with cell proliferation in the mouse liver.
abstract: Oxidative stress is known to produce tissue injury and to activate various signaling pathways. To investigate the molecular events linked to acute oxidative stress in mouse liver, we injected a toxic dose of paraquat. Liver necrosis was first observed, followed by histological marks of cell proliferation. Concomitantly, activation of the MAP kinase pathway and increased levels of the anti-apoptotic protein Bcl-XL were observed. Gene expression profiles revealed that the differentially expressed genes were potentially involved in cell proliferation. These data suggest that paraquat-induced acute oxidative stress triggers the activation of regeneration-related events in the liver.
authors.affiliation: EA 3674 - Laboratoire de Biologie de la Différenciation et du Développement, Université de Bordeaux 2, 146 Rue Léo-Saignat, 33076 Bordeaux Cedex, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Dragin
authors.forename: Moneïm
authors.initials: M
authors.lastname: Smani
authors.forename: Sandrine
authors.initials: S
authors.lastname: Arnaud-Dabernat
authors.forename: Clément
authors.initials: C
authors.lastname: Dubost
authors.forename: Isabelle
authors.initials: I
authors.lastname: Moranvillier
authors.forename: Pierre
authors.initials: P
authors.lastname: Costet
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Daniel
authors.forename: Evelyne
authors.initials: E
authors.lastname: Peuchant
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001973:Bromodeoxyuridine; D049109:Cell Proliferation; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005796:Genes / Q000235:genetics; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009336:Necrosis; D020411:Oligonucleotide Array Sequence Analysis; D018384:Oxidative Stress; D010269:Paraquat / Q000494:pharmacology; D010766:Phosphorylation; D013997:Time Factors; D015854:Up-Regulation / Q000235:genetics; D051020:bcl-X Protein / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D051020:bcl-X Protein; D004247:DNA; D000410:Alanine Transaminase; D048049:Extracellular Signal-Regulated MAP Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D001973:Bromodeoxyuridine; D010269:Paraquat