Viral immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling in cell transformation and cancer.
Viruses frequently co-opt host cell pathways to enhance their propagation or to enable latent infection. Certain receptors expressed by hematopoietic cells have immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domains that initiate cellular activation, proliferation and differentiation. Some viruses have evolved, or acquired from their host, genes that encode ITAM-bearing proteins. These ITAM-bearing viral proteins have been implicated in cellular transformation in virus-infected hematopoietic cells, typically B cells, but also in non-hematopoietic tissues--including endothelial and epithelial cells.
Lanier
Lewis L
LL
Department of Microbiology and Immunology and the Cancer Research Institute, University of California-San Francisco, 513 Parnassus Avenue, HSE 1001G, San Francisco, CA 94143-00414, USA. lewis.lanier@ucsf.edu
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral / Q000502:physiology*; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D001909:Leukemia Virus, Bovine; D008324:Mammary Tumor Virus, Mouse; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D000072377:Syk Kinase; D014443:Tyrosine / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology*; D019061:src-Family Kinases / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; C111600:K1 protein, Human herpesvirus 8; D011971:Receptors, Immunologic; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D019061:src-Family Kinases