title: The CAP cancer protocols--a case study of caCORE based data standards implementation to integrate with the Cancer Biomedical Informatics Grid.
abstract: BACKGROUND
  The Cancer Biomedical Informatics Grid (caBIG) is a network of individuals and institutions, creating a world wide web of cancer research. An important aspect of this informatics effort is the development of consistent practices for data standards development, using a multi-tier approach that facilitates semantic interoperability of systems. The semantic tiers include (1) information models, (2) common data elements, and (3) controlled terminologies and ontologies. The College of American Pathologists (CAP) cancer protocols and checklists are an important reporting standard in pathology, for which no complete electronic data standard is currently available.
  
  
  METHODS
  In this manuscript, we provide a case study of Cancer Common Ontologic Representation Environment (caCORE) data standard implementation of the CAP cancer protocols and checklists model--an existing and complex paper based standard. We illustrate the basic principles, goals and methodology for developing caBIG models.
  
  
  RESULTS
  Using this example, we describe the process required to develop the model, the technologies and data standards on which the process and models are based, and the results of the modeling effort. We address difficulties we encountered and modifications to caCORE that will address these problems. In addition, we describe four ongoing development projects that will use the emerging CAP data standards to achieve integration of tissue banking and laboratory information systems.
  
  
  CONCLUSIONS
  The CAP cancer checklists can be used as the basis for an electronic data standard in pathology using the caBIG semantic modeling methodology.
authors.affiliation: Department of Pathology, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA. jotobias@mednet.ucla.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tobias
authors.forename: Ram
authors.initials: R
authors.lastname: Chilukuri
authors.forename: George A
authors.initials: GA
authors.lastname: Komatsoulis
authors.forename: Sambit
authors.initials: S
authors.lastname: Mohanty
authors.forename: Nicholas
authors.initials: N
authors.lastname: Sioutos
authors.forename: Denise B
authors.initials: DB
authors.lastname: Warzel
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Wright
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Crowley
mesh_terms: D002985:Clinical Protocols; D003628:Database Management Systems; D006801:Humans; D020407:Internet; D008490:Medical Informatics; D008495:Medical Oncology / Q000592:standards*; D009316:National Institutes of Health (U.S.); D009323:Natural Language Processing; D009369:Neoplasms / Q000145:classification / Q000473:pathology*; D010338:Pathology, Clinical / Q000592:standards*; D012660:Semantics; D018511:Systems Integration; D014481:United States; D014584:User-Computer Interface; D018875:Vocabulary, Controlled