title: Renal damage in primary aldosteronism: results of the PAPY Study.
abstract: Primary aldosteronism (PA) has been associated with cardiovascular hypertrophy and fibrosis, in part independent of the blood pressure level, but deleterious effects on the kidneys are less clear. Likewise, it remains unknown if the kidney can be diversely involved in PA caused by aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). Hence, in the Primary Aldosteronism Prevalence in Italy (PAPY) Study, a prospective survey of newly diagnosed consecutive patients referred to hypertension centers nationwide, we sought signs of renal damage in patients with PA and in comparable patients with primary hypertension (PH). Patients (n = 1180) underwent a predefined screening protocol followed by tests for confirming PA and identifying the underlying adrenocortical pathology. Renal damage was assessed by 24-hour urine albumin excretion (UAE) rate and glomerular filtration rate (GFR). UAE rate was measured in 490 patients; all had a normal GFR. Of them, 31 (6.4%) had APA, 33 (6.7%) had IHA, and the rest (86.9%) had PH. UAE rate was predicted (P < 0.001) by body mass index, age, urinary Na+ excretion, serum K+, and mean blood pressure. Covariate-adjusted UAE rate was significantly higher in APA and IHA than in PH patients; there were more patients with microalbuminuria in the APA and IHA than in the PH group (P = 0.007). Among the hypertensive patients with a preserved GFR, those with APA or IHA have a higher UAE rate than comparable PH patients. Thus, hypertension because of excess autonomous aldosterone secretion features an early and more prominent renal damage than PH.
authors.affiliation: Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, via Giustiniani, 2, 35126 Padova, Italy. gianpaolo.rossi@unipd.it
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Rossi
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Bernini
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Desideri
authors.forename: Bruno
authors.initials: B
authors.lastname: Fabris
authors.forename: Claudio
authors.initials: C
authors.lastname: Ferri
authors.forename: Gilberta
authors.initials: G
authors.lastname: Giacchetti
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
authors.forename: Mauro
authors.initials: M
authors.lastname: Maccario
authors.forename: Massimo
authors.initials: M
authors.lastname: Mannelli
authors.forename: Mee-Jung
authors.initials: MJ
authors.lastname: Matterello
authors.forename: Domenico
authors.initials: D
authors.lastname: Montemurro
authors.forename: Gaetana
authors.initials: G
authors.lastname: Palumbo
authors.forename: Damiano
authors.initials: D
authors.lastname: Rizzoni
authors.forename: Ermanno
authors.initials: E
authors.lastname: Rossi
authors.forename: Achille Cesare
authors.initials: AC
authors.lastname: Pessina
authors.forename: Franco
authors.initials: F
authors.lastname: Mantero
mesh_terms: D000419:Albuminuria / Q000453:epidemiology* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D003404:Creatinine / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D007558:Italy / Q000453:epidemiology; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D007677:Kidney Function Tests; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D012083:Renin / Q000097:blood
chemical_list: D015415:Biomarkers; D003404:Creatinine; D012083:Renin; D011188:Potassium