Autologous transplantation of CD133+ BM-derived stem cells as a therapeutic option for dilatative cardiomyopathy.
We report the case of a 58-year-old man with end-stage non-ischemic cardiomyopathy. Baseline transthoracic echocardiography (TTE) and cardiac magnetic resonance (cMRI) revealed a markedly depressed left ventricle systolic function. He underwent autologous CD133+ BM-derived cell transplantation through a minimally invasive approach. During surgery 19 x 10(6) BM-derived stem cells were injected by the transepimyocardial route. Six months after the operation TTE and cMRI showed a clear improvement in left ventricular contractility.
Ghodsizad
A
A
Ruhparwar
A
A
Marktanner
R
R
Borowski
A
A
Mohammad Hasani
M R
MR
Poll
L
L
Vshivkov
I
I
Stoldt
V
V
Voelkel
T
T
Piechaczek
C
C
Burchardt
E R
ER
Stockschlaeder
M
M
Sucker
C
C
Gams
E
E
Klein
H M
HM
D000071916:AC133 Antigen; D015703:Antigens, CD / Q000032:analysis*; D001854:Bone Marrow Cells / Q000737:chemistry / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004452:Echocardiography; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology*; D013318:Stroke Volume / Q000502:physiology; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides