L-nucleoside enantiomers as antivirals drugs: a mini-review.
The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents.
Mathé
Christophe
C
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Case Courrier 008, Place Eugène Bataillon, 34095 Montpellier, France.
Gosselin
Gilles
G
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D014777:Virus Diseases / Q000821:virology; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D009705:Nucleosides