[Venous endothelial dysfunction in Chagas' disease patients without heart failure].
OBJECTIVE
To analyze the venous endothelial function in Chagas' disease patients without heart failure.


METHODS
The Chagas' disease Group (G1) was composed by 14 women and 2 men aged 46 +/- 2.7 and the Control Group (G0) by 7 women and 1 man matched by age, weight and height. Dorsal Hand Vein Compliance Technique was used to evaluate the venous endothelial function. Crescent doses of phenylephrine were infused to get a 70% pre-constriction of the vein; after that, acetylcholine and sodium nitroprusside were respectively administrated to analyze the endothelium-dependent and -independent venodilation.


RESULTS
No significant systemic hemodynamic changes were observed in both groups during the experiment. The necessary phenylephrine dose to reach 70% pre-constriction of the vein was significantly higher in the G1 (1116 +/- 668.2 ng/ml) compared to G0 (103 +/- 28 ng/ml) p = 0.05. The endothelium-dependent venous dilation was significantly lower in G1 (65.5 +/- 8%) compared to G0 (137 +/- 20%) p = 0.009. No difference was observed in the endothelium-independent venous dilatation between groups.


CONCLUSIONS
Patients with Chagas' disease without heart failure presented venous endothelial dysfunction.
Plentz
Rodrigo Della Méa
RD
Universidade Federal de São Paulo, Instituto do Coração, Hospital das Clínicas, FMUSP, São Paulo, SP. roplentz@yahoo.com.br
Irigoyen
Maria Claudia
MC
Muller
Andreia Simone
AS
Casarini
Dulce Elena
DE
Rubira
Marcelo Custodio
MC
Moreno Junior
Heitor
H
Mady
Charles
C
Ianni
Bárbara Maria
BM
Krieger
Eduardo Moacir
EM
Consolim-Colombo
Fernanda
F
D000109:Acetylcholine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine; D000109:Acetylcholine