title: Use of whole blood platelet lumi-aggregometry to optimize anti-platelet therapy in patients with chronic myeloproliferative disorders.
abstract: Twenty-seven patients with chronic myeloproliferative disorders and in vitro evidence of platelet hyperactivity on whole blood platelet lumi-aggregometry were commenced on anti-platelet therapy comprising aspirin, clopidogrel, and/or odorless garlic and the studies were repeated to assess the efficacy of the therapeutic agent(s). Only 8 patients showed clear evidence of anti-platelet effect while receiving the standard low-dose (100 mg/day) aspirin therapy. Thirteen patients required a higher dosage of aspirin and/or an additional anti-platelet agent to achieve therapeutic adequacy. Lumi-aggregometry also proved useful to optimize therapy in the 6 patients who received clopidogrel or odorless garlic because of aspirin intolerance.
authors.affiliation: Department of Clinical Haematology , St George Hospital, Sydney, Australia. a.manoharan@unsw.edu.au
authors.forename: A
authors.initials: A
authors.lastname: Manoharan
authors.forename: R
authors.initials: R
authors.lastname: Gemmell
authors.forename: T
authors.initials: T
authors.lastname: Hartwell
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D000077144:Clopidogrel; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005737:Garlic; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods; D009196:Myeloproliferative Disorders / Q000097:blood / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D010979:Platelet Function Tests / Q000379:methods; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin