[Ambroxol-induced immune hemolytic anemia].
BACKGROUND
Drug-induced immune hemolytic anemia is a rare cause of hemolytic anemia.


METHODS
A 68-year-old male patient developed an acute intravascular hemolysis with acute renal failure. Common causes of hemolysis were ruled out and the patient rapidly improved. An immune mechanism was confirmed by the positivity of the direct antiglobulin test with anti-IgA in the presence of ambroxol only, one of the drug the patient had received during 6 days before hospitalization.


CONCLUSIONS
To our knowledge, this is the first report of ambroxol-induced immune hemolytic anemia. This case also underlined that the direct antiglobulin test should also be performed with anti-IgA to rule out any false negative.
Guitard
M
M
Service de médecine interne, centre hospitalier Saint-Joseph-Saint-Luc, 20, quai Claude-Bernard, 69365 Lyon cedex 07, France.
Giannoli
C
C
Bachet
P
P
Vial
T
T
D000368:Aged; D000551:Ambroxol / Q000009:adverse effects*; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology* / Q000276:immunology; D003298:Coombs Test; D005100:Expectorants / Q000009:adverse effects*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology; D008297:Male
D005100:Expectorants; D007070:Immunoglobulin A; D007155:Immunologic Factors; D000551:Ambroxol