title: Statement of the problem.
abstract: The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) study poses 2 questions. Of the options in treating the hyperglycemia of type 2 diabetes mellitus, which, if either, would be best for decreasing the likelihood of death or a serious cardiovascular disease event such as a heart attack: correcting the relative insulin deficiency or reducing insulin resistance? Do individuals with diabetes whose coronary disease can be managed medically have a better outcome with initial medical or interventional (percutaneous intervention or coronary artery bypass grafting) treatment? This article outlines the reasons for asking these questions.
authors.affiliation: University of Toronto and Toronto General Hospital, Toronto, Ontario, Canada. george.steiner@uhn.on.ca
authors.forename: George
authors.initials: G
authors.lastname: Steiner
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000628:therapy*; D006801:Humans; D009204:Myocardial Revascularization; D016032:Randomized Controlled Trials as Topic; D012107:Research Design