Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum.
Although the association between inflammatory bowel disease and gastrointestinal infections has been suggested, the mechanisms involved in the pathogenesis of Crohn's disease (CD) are still undetermined. We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn's disease. This case is in keeping with recent evidence in the literature which suggests that CD is a disease linked to abnormal immune responses to enteric bacteria in genetically susceptible individuals.
Zippi
Maddalena
M
Department of Clinical Sciences, Umberto I Viale del Policlinico 155, Rome, Italy. maddyzip@yahoo.it
Colaiacomo
Maria Chiara
MC
Marcheggiano
Adriana
A
Pica
Roberta
R
Paoluzi
Paolo
P
Iaiani
Giancarlo
G
Caprilli
Renzo
R
Maccioni
Francesca
F
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D003424:Crohn Disease / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D020022:Genetic Predisposition to Disease; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology; D007082:Ileum / Q000473:pathology; D008297:Male; D008640:Mesenteric Lymphadenitis / Q000150:complications* / Q000276:immunology / Q000382:microbiology*; D015011:Yersinia pseudotuberculosis / Q000276:immunology / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000150:complications* / Q000276:immunology
D000907:Antibodies, Bacterial; D000949:Histocompatibility Antigens Class II