title: Cognitive dysfunction in congestive heart failure: transcranial Doppler evidence of microembolic etiology.
abstract: Cognitive symptoms are common in patients with congestive heart failure (CHF) and are usually attributed to low cerebral blood flow. In the present study, we aimed to evaluate global cognitive function (Mini Mental State Exam MMSE) in relation to both cardiac function (evaluated by echocardiogram) and cerebrovascular hemodynamics (evaluated by transcranial Doppler TCD) in CHF patients. In 83 patients studied, no correlation was found between echocardiographic parameters and MMSE scores. In contrast, a significant correlation was found between right middle cerebral artery (RMCA) mean flow velocity and MMSE score (r=0.231 p=0.039), as well as between RMCA pulsatility index and MMSE score (rs= -0.292 p=0.015). After excluding patients with a previous history of stroke, only RMCA pulsatility index correlated with MMSE score (rs=-0,314 p=0,007). The relationship between high cerebrovascular resistance and worse cognitive scores suggest that microembolism may be responsible for a significant proportion of cognitive symptoms in CHF patients.
authors.affiliation: Cardiomyopathy Clinic, Federal University of Bahia, Salvador, BA, Brazil.
authors.forename: Pedro A P
authors.initials: PA
authors.lastname: Jesus
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Vieira-de-Melo
authors.forename: Francisco J F B
authors.initials: FJ
authors.lastname: Reis
authors.forename: Leila C
authors.initials: LC
authors.lastname: Viana
authors.forename: Amanda
authors.initials: A
authors.lastname: Lacerda
authors.forename: Jesangeli S
authors.initials: JS
authors.lastname: Dias
authors.forename: Jamary
authors.initials: J
authors.lastname: Oliveira-Filho
mesh_terms: D001783:Blood Flow Velocity; D003072:Cognition Disorders / Q000209:etiology*; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D017585:Ultrasonography, Doppler, Transcranial; D014655:Vascular Resistance