Radical-polar crossover domino reactions involving organozinc and mixed organocopper/organozinc reagents.
A domino process involving Michael addition and carbocyclization has been developed starting from beta-N-allylamino enoates and various organometallic reagents (organozinc halides, diorganozinc reagents, and copper/zinc mixed species). In all cases the mechanism of this domino reaction has been evidenced to involve a radical-polar crossover mechanism.
Denes
Fabrice
F
Université Pierre et Marie Curie - Paris 6, Laboratoire de chimie organique (UMR CNRS 7611), Institut de chimie moléculaire (FR 2769) case 183, 4 place Jussieu, 75252 Paris cedex 05, France.
Cutri
Sabrina
S
Perez-Luna
Alejandro
A
Chemla
Fabrice
F