title: Bone metastases from head and neck paragangliomas: uncommon MR findings in an uncommon condition--report of three cases.
abstract: Malignancy (defined as metastatic disease) has been reported in nearly 5% of head and neck paragangliomas. Metastases preferentially target the lymph nodes, lung, liver, or bone. We describe three patients with multiple silent bone metastases exhibiting a fatty halo at MRI that coexisted with expansive bone lesions. In all cases, (123)I-metaiodobenzylguanidine ((123)MIBG) scintigraphy showed no abnormal tracer uptake, whereas (111)In-pentetreotide scintigraphy visualized a few silent bone metastases. These findings indicate that MRI should be included in the staging of paraganglioma patients with risk factors for malignancy.
authors.affiliation: Nuclear Medicine Department, Lariboisière Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Paris VII University, Paris, France. michele.duet@lrb.ap-hop-paris.fr
authors.forename: Michèle
authors.initials: M
authors.lastname: Duet
authors.forename: Philippe
authors.initials: P
authors.lastname: Herman
authors.forename: Michel
authors.initials: M
authors.lastname: Wassef
authors.forename: Ba Huy Patrice
authors.initials: BH
authors.lastname: Tran
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Laredo
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010236:Paraganglioma, Extra-Adrenal / Q000000981:diagnostic imaging / Q000556:secondary*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013004:Somatostatin / Q000031:analogs & derivatives; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary
chemical_list: D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D013004:Somatostatin; C081788:pentetreotide