title: Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study.
abstract: The study was conducted to investigate the effect of conservative surgery of ovarian endometriomas before an ICSI cycle. Ninety-nine patients with endometriomas who were referred to an intracytoplasmic sperm injection (ICSI) cycle were enrolled in the study. The patients were prospectively randomized into two groups; group I (49 patients) underwent conservative ovarian surgery before the ICSI cycle and group II (50 patients) underwent the ICSI cycle directly. The stimulation was started 3 months after the operation in group I and directly in group II. In the ovarian surgery group, stimulation was significantly longer (14.0 days in group I and 10.8 days in group II; P = 0.001), total recombinant FSH dose was significantly higher (4575 IU in group I and 3675 IU in group II; P = 0.001), and mean number of mature oocytes was significantly lower (7.8 in group I and 8.6 in group II; P = 0.032). There was no difference in terms of fertilization (86% in group I and 88% in group II), implantation (16.5% in group I and 18.5% in group II) and pregnancy rates (34% in group I and 38% in group II). Ovarian surgery resulted in longer stimulation, higher FSH requirement and lower oocyte number, but fertilization, pregnancy and implantation rates did not differ between the groups.
authors.affiliation: Clinic Women Health, Infertility and IVF Centre, Cankaya Caddesi, no. 20/3, Ankara, Turkey. ademirol@gmail.com
authors.forename: Aygül
authors.initials: A
authors.lastname: Demirol
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Cem
authors.initials: C
authors.lastname: Baykal
authors.forename: Timur
authors.initials: T
authors.lastname: Gurgan
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010049:Ovarian Diseases / Q000601:surgery*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods