Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy.
To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 to 14.1 years). Fifty-three percent of patients were seizure free at 10 years. The authors identified multiple predictors of recurrence. Results of EEG performed 6 months postoperatively correlated with occurrence and severity of seizure recurrence, in addition to breakthrough seizures with discontinuation of antiepileptic drugs.
Jeha
L E
LE
Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. jehil@ccf.org
Najm
I M
IM
Bingaman
W E
WE
Khandwala
F
F
Widdess-Walsh
P
P
Morris
H H
HH
Dinner
D S
DS
Nair
D
D
Foldvary-Schaeffer
N
N
Prayson
R A
RA
Comair
Y
Y
O'Brien
R
R
Bulacio
J
J
Gupta
A
A
Lüders
H O
HO
D038481:Anterior Temporal Lobectomy / Q000706:statistics & numerical data*; D000927:Anticonvulsants / Q000627:therapeutic use; D002908:Chronic Disease; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D055502:Secondary Prevention; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000601:surgery; D017211:Treatment Failure; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
D000927:Anticonvulsants