title: A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice.
abstract: Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Gee Young
authors.initials: GY
authors.lastname: Suh
authors.forename: Hyoung Suk
authors.initials: HS
authors.lastname: Ham
authors.forename: Shin-Hye
authors.initials: SH
authors.lastname: Lee
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Choi
authors.forename: Won-Jung
authors.initials: WJ
authors.lastname: Koh
authors.forename: Soo-Youl
authors.initials: SY
authors.lastname: Kim
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Joungho
authors.initials: J
authors.lastname: Han
authors.forename: Hong Pyo
authors.initials: HP
authors.lastname: Kim
authors.forename: Augustine M K
authors.initials: AM
authors.lastname: Choi
authors.forename: O Jung
authors.initials: OJ
authors.lastname: Kwon
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000166:cytology / Q000276:immunology; D010446:Peptide Fragments / Q000494:pharmacology*; D011014:Pneumonia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010446:Peptide Fragments; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D011503:Transglutaminases