title: The effect of adenosine 5'-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells.
abstract: OBJECTIVE
  To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.
  
  
  METHODS
  Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.
  
  
  RESULTS
  Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappaB in all cell lines used.
  
  
  CONCLUSIONS
  These results suggest that calcium mobilization and NF-kappaB dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
authors.affiliation: Catholic Neuroscience Center, Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
authors.forename: Seok Geun
authors.initials: SG
authors.lastname: Lee
authors.forename: Jung-Kyoung
authors.initials: JK
authors.lastname: Choi
authors.forename: Byung Hyune
authors.initials: BH
authors.lastname: Choi
authors.forename: Young
authors.initials: Y
authors.lastname: Lim
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Kweon-Haeng
authors.initials: KH
authors.lastname: Lee
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Shin
authors.forename: Woong Shick
authors.initials: WS
authors.lastname: Ahn
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D000255:Adenosine Triphosphate; D002118:Calcium