title: Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.
abstract: A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Paget
authors.forename: Christine M
authors.initials: CM
authors.lastname: Boggs
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Foleno
authors.forename: Raul M
authors.initials: RM
authors.lastname: Goldschmidt
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Hlasta
authors.forename: Michele A
authors.initials: MA
authors.lastname: Weidner-Wells
authors.forename: Harvey M
authors.initials: HM
authors.lastname: Werblood
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Macielag
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects; D000069349:Linezolid; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011725:Pyridines; C030686:acetamide; D000069349:Linezolid; C023666:pyridine