title: Cerebral blood flow and oxygenation during head-up tilt in patients with multiple system atrophy and healthy control subjects.
abstract: To assess cerebral hemodynamics in patients with multiple system atrophy (MSA), cerebral blood flow and oxygenation were evaluated in 7 MSA patients and 9 healthy controls during a head-up tilt test (HUT) by means of transcranial Doppler ultrasonography and near-infrared spectrophotometry. In the MSA patients examined, the perfusion pressure reduction during HUT was marked, but severe reduction in blood flow velocity was prevented because of a decrease in cerebrovascular resistance. The MSA patients showed no severe reduction in cerebral oxygenation during HUT. These findings indicate that our MSA patients exhibited a compensatory cerebral vasodilatation response to orthostatic hypotension.
authors.affiliation: Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260 8670, Japan. asahina@faculty.chiba-u.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Asahina
authors.forename: Jiro
authors.initials: J
authors.lastname: Sato
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tachibana
authors.forename: Takamichi
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000368:Aged; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006257:Head; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000097:blood / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011187:Posture; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods
chemical_list: D010100:Oxygen