title: Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.
abstract: Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.
authors.affiliation: Research Center Borstel, Department of Immunochemistry and Biochemical Microbiology, Division of Biophysics, Parkallee 10, 23845 Borstel, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Scheel
authors.forename: Martin
authors.initials: M
authors.lastname: Papavlassopoulos
authors.forename: Rikard
authors.initials: R
authors.lastname: Blunck
authors.forename: Andreas
authors.initials: A
authors.lastname: Gebert
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Ulrich
authors.initials: U
authors.lastname: Zähringer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Seydel
authors.forename: Andra B
authors.initials: AB
authors.lastname: Schromm
mesh_terms: D002460:Cell Line; D006801:Humans; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Q000502:physiology*; D008024:Ligands; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D005810:Multigene Family; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*
chemical_list: C494841:KCNMA1 protein, human; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D008024:Ligands; D017472:Receptors, Interleukin-1; D051193:Toll-Like Receptors