title: Drug discovery from natural sources.
abstract: Organic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 and 2005, originating from terrestrial plants, terrestrial microorganisms, marine organisms, and terrestrial vertebrates and invertebrates, are described. These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Marcy J
authors.initials: MJ
authors.lastname: Balunas
authors.forename: Hee Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000254:growth & development; D001688:Biological Products; D005658:Fungi / Q000254:growth & development; D007448:Invertebrates; D010406:Penicillins / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D008517:Phytotherapy; D010944:Plants / Q000737:chemistry*; D014714:Vertebrates
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D010406:Penicillins; D004364:Pharmaceutical Preparations