title: New features in synthesis of talampanel related 2,3-benzodiazepines.
abstract: Analogues of talampanel (1), a highly active AMPA antagonist 2,3-benzodiazepine, were synthesized, where the characteristic amino-function was either transposed or sterically shielded. For the key intermediates (hemiketals 6a, b) a new synthetic method of different mechanism was developed. The inactivity of several new compounds indicates the significance of the 4-amino(phenyl) function in BDZs of type 1.
authors.affiliation: IVAX Drug Research Institute Ltd., H-1045 Budapest, Berlini u. 47-49, Hungary. sandor.solyom@idri.hu
authors.forename: Sándor
authors.initials: S
authors.lastname: Sólyom
authors.forename: István
authors.initials: I
authors.lastname: Pallagi
authors.forename: Gizella
authors.initials: G
authors.lastname: Abrahám
authors.forename: Máriusz
authors.initials: M
authors.lastname: Kertész
authors.forename: Gyula
authors.initials: G
authors.lastname: Horváth
authors.forename: Pál
authors.initials: P
authors.lastname: Berzsenyi
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D001569:Benzodiazepines; C085266:talampanel