Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
[reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.
Kuo
Ping-Chung
PC
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Kuo
Tsung-Hsiao
TH
Damu
Amooru G
AG
Su
Chung-Ren
CR
Lee
E-Jian
EJ
Wu
Tian-Shung
TS
Shu
Rexen
R
Chen
Chou-Ming
CM
Bastow
Kenneth F
KF
Chen
Tzu-Hsuan
TH
Lee
Kuo-Hsiung
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032321:Physalis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D013256:Steroids; C518941:physanolide A