High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan.
Recent studies have linked simian virus 40 (SV40) to non-Hodgkin's lymphoma (NHL), especially in countries in which people were exposed to contaminated polio vaccines prior to 1963. In Taiwan, nearly all children were not exposed to contaminated polio vaccine during this period; the relationship between SV40 infection and hematological malignancies is unclear and deserves to be studied. Using PCR amplification of SV40 large T antigen DNA, confirmed by Southern blot hybridization and sequence analysis, 91 frozen lymph nodes from NHL patients were examined. Thirteen (14.3 percent) showed positive for SV40. All other test samples, including diagnostic bone marrow from patients with acute leukemia, peripheral blood from 10 relatives of SV40 positive-patients and 91 age-matched normal volunteers, and 5 reactive hyperplastic lymphoid tissues, showed negative. These results may reflect that human-to-human transmission of SV40 is independent of contaminated polio vaccines; and SV40 is possibly associated with the development of NHL in Taiwan (p = 0.0001). Prospective studies are needed to determine the prevalence of SV40 infections in our and other human populations and to explore the means of transmission of the virus.
Chen
Po-Min
PM
Division of Medical Oncology, Department of Medicine, Taipei Veteran General Hospital, Taipei, Taiwan, Republic of China.
Yen
Chueh-Chuan
CC
Yang
Muh-Hwa
MH
Poh
Say-Bee
SB
Hsiao
Liang-Tsai
LT
Wang
Wei-Shu
WS
Lin
Peng-Chan
PC
Lee
Ming-Yang
MY
Teng
Hao-Wei
HW
Bai
Li-Yuan
LY
Chu
Chiau-Jun
CJ
Chao
Shu-Chauo
SC
Yang
An-Hang
AH
Chiou
Tzeon-Jye
TJ
Liu
Jin-Hwang
JH
Chao
Ta-Chung
TC
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000952:Antigens, Polyomavirus Transforming / Q000032:analysis; D015139:Blotting, Southern; D001854:Bone Marrow Cells / Q000821:virology; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007938:Leukemia / Q000821:virology; D008198:Lymph Nodes / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D008297:Male; D008875:Middle Aged; D023321:Poliovirus Vaccines / Q000009:adverse effects*; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000635:transmission*; D015995:Prevalence; D013539:Simian virus 40; D013624:Taiwan; D014412:Tumor Virus Infections / Q000453:epidemiology
D000952:Antigens, Polyomavirus Transforming; D023321:Poliovirus Vaccines