title: Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis.
abstract: A paradoxical increase in circulating Aspergillus antigen was observed during treatment with caspofungin in a patient with proven invasive aspergillosis. With the exception of treatment with the echinocandin, no other factors were found that might explain this clinical observation, which was supported by experiments done in vitro.
authors.affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. r.klont@mmb.umcn.nl
authors.forename: Rocus R
authors.initials: RR
authors.lastname: Klont
authors.forename: Monique A S H
authors.initials: MA
authors.lastname: Mennink-Kersten
authors.forename: Dorien
authors.initials: D
authors.lastname: Ruegebrink
authors.forename: Antonius J M M
authors.initials: AJ
authors.lastname: Rijs
authors.forename: Nicole M A
authors.initials: NM
authors.lastname: Blijlevens
authors.forename: J Peter
authors.initials: JP
authors.lastname: Donnelly
authors.forename: Paul E
authors.initials: PE
authors.lastname: Verweij
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000097:blood*; D001228:Aspergillosis / Q000188:drug therapy* / Q000276:immunology; D001232:Aspergillus fumigatus / Q000276:immunology*; D000077336:Caspofungin; D054714:Echinocandins; D005656:Fungal Proteins / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy; D010456:Peptides, Cyclic / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D054714:Echinocandins; D005656:Fungal Proteins; D007166:Immunosuppressive Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; C007572:echinocandin B; D000077336:Caspofungin