title: Association between exposure to cadmium and blood pressure in Japanese peoples.
abstract: The authors studied the effects of environmental cadmium exposure on blood pressure (BP). Subjects 1140 men and 1713 women, aged > or =50 yr lived in three areas of Japan considered "unpolluted" by cadmium. Multiple logistic regression analysis was used to evaluate relationships between hypertension/nonhypertension and cadmium concentrations in blood (B-Cd) or urine (U-Cd). Age, body mass index, drinking and smoking habits, and blood and urine chemistry data were incorporated into the model. Odds ratios for hypertension were significantly less than 1 in either gender when U-Cd was the indicator of cadmium exposure and hypertension was defined as systolic BP > or =140 mmHg and/or diastolic BP > or =90 mmHg. The results suggest a significant negative association between cadmium exposure and BP in inhabitants in Japan.
authors.affiliation: Chiba University Graduate School of Medicine, Department of Occupational and Environmental Medicine, Chiba, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kurihara
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suwazono
authors.forename: Mirei
authors.initials: M
authors.lastname: Uetani
authors.forename: Takeya
authors.initials: T
authors.lastname: Inaba
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Oishiz
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kido
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Koji
authors.initials: K
authors.lastname: Nogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D016021:Epidemiologic Studies; D005260:Female; D005843:Geography; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D002104:Cadmium