title: Intracranial hemorrhage due to late hemorrhagic disease in two siblings.
abstract: Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized by intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency, occurring particularly in exclusively breastfed infants. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. In this study, we report on two siblings with intracranial bleeding who were fully breastfed without a routine supplementation of vitamin K. Vitamin K should be given to all newborns as a single, intramuscular dose of 1 mg.
authors.affiliation: Department of Pediatric Neurology, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Per
authors.forename: Sefer
authors.initials: S
authors.lastname: Kumandaş
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ozdemir
authors.forename: Hakan
authors.initials: H
authors.lastname: Gümüş
authors.forename: Musa
authors.initials: M
authors.lastname: Karakukcu
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008297:Male; D014057:Tomography, X-Ray Computed; D014813:Vitamin K Deficiency / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006475:Vitamin K Deficiency Bleeding / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy