title: Porfimer sodium photodynamic therapy for management of Barrett's esophagus with high-grade dysplasia.
abstract: Porfimer sodium photodynamic therapy (ps-PDT) for Barrett's esophagus is a powerful endoscopic treatment that can eliminate high-grade dysplasia (HGD) and Barrett's mucosa and reduce the risk of development of cancer in these patients. Ps-PDT typically results in destruction of Barrett's esophagus in the majority of the treated area. However, residual small island of Barrett's mucosa may persist after PDT. Therefore, adjuvant thermal ablation should be available during follow-up endoscopies for ablation of residual islands of Barrett's mucosa. PDT should be applied concurrent with effective proton pump inhibitor therapy. This article provides a practical guide for application of porfimer sodium balloon PDT for management of Barrett's esophagus with HGD. Recommendations are provided for patient selection and screening, delivery of PDT to include light dosimetry, methodology for follow-up endoscopies, as well as discussing the potential side effects and complications.
authors.affiliation: Center of Excellence for Treatment of Barrett's Esophagus, Thompson Cancer Survival Center, 1915 White Avenue, Knoxville, Tennessee 37916, USA. mpanjehp@covhlth.com
authors.forename: Masoud
authors.initials: M
authors.lastname: Panjehpour
authors.forename: Bergein F
authors.initials: BF
authors.lastname: Overholt
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000188:drug therapy*; D017115:Catheter Ablation; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D004940:Esophageal Stenosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D009092:Mucous Membrane / Q000601:surgery; D009853:Omeprazole / Q000627:therapeutic use; D018579:Patient Selection; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000897:Anti-Ulcer Agents; D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether; D009853:Omeprazole