title: Pattern of renal function deterioration as a predictive factor of unilateral ureteropelvic junction obstruction treatment.
abstract: OBJECTIVE
  To assess the process of renal function deterioration in patients with unilateral ureteropelvic junction (UPJ) obstruction and its impact on their treatment course.
  
  
  METHODS
  The files of patients treated for unilateral UPJ obstruction at our department from 1996 to 2003 were retrospectively reviewed. All patients were initially treated conservatively and followed up regularly. Criteria for conversion to surgical treatment were increase in anteroposterial renal pelvis diameter, increase in T(1/2) washout pattern, and drop of relative renal function (RRF) below 40% in diuretic renogram. Patients operated on because of multiple urinary infections, pelvic stones, or solitary kidneys were excluded. Patients were divided into group A, which included those whose treatment was converted from conservative to surgical, and group B in which patients were treated conservatively. All patients operated on underwent dismembered pyeloplasty.
  
  
  RESULTS
  Sixty-four patients with grade three or four hydronephrosis in postnatal ultrasound examination and an obstructive pattern in diuretic renogram were studied. All group A patients (n=47) reached an RRF below 40%; in 41 (87.2%) deterioration of RRF was detected in at least two sequential follow-up studies. In group B patients (n=17), deterioration was also detected in seven (41.1%) patients in two sequential studies (p<0.0005), although the RRF never dropped below 40%. No differences in gender, side of obstruction, or frequency of follow-up were detected between the two groups.
  
  
  CONCLUSIONS
  RRF deterioration and its progression for at least two sequential follow-ups could serve as a predictive factor for surgical treatment.
authors.affiliation: Pediatric Surgery Department, Hippokration General Hospital, Thessaloniki, Greece. xkaselas@otenet.gr <xkaselas@otenet.gr>
authors.forename: Christos
authors.initials: C
authors.lastname: Kaselas
authors.forename: Georgios
authors.initials: G
authors.lastname: Papouis
authors.forename: Georgios
authors.initials: G
authors.lastname: Grigoriadis
authors.forename: Aris
authors.initials: A
authors.lastname: Klokkaris
authors.forename: Vasilios
authors.initials: V
authors.lastname: Kaselas
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology*; D007682:Kidney Pelvis; D008297:Male; D012189:Retrospective Studies; D014517:Ureteral Obstruction / Q000503:physiopathology* / Q000628:therapy*