Destabilizing heterochromatin: Does Swi6/HP1 make the choice?
HP1 is well known as a key silencing protein. However, in the June 9 issue of Molecular Cell, report that Swi6/HP1 recruits an antisilencing protein, Epe1, to facilitate transcription, leading to a model in which Swi6/HP1 is used as a platform to recruit both silencing and antisilencing activities.
Verdel
André
A
Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM 309, Institut Albert Bonniot, 38706, La Tronche, France. Electronic address: verdel@ujf-grenoble.fr.
D000818:Animals; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D020868:Gene Silencing / Q000502:physiology*; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*
D002868:Chromosomal Proteins, Non-Histone; D006570:Heterochromatin; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins; C465958:Swi6 protein, S pombe; C475031:epe1 protein, S pombe; D000090266:Chromobox Protein Homolog 5