Candidate genes in women with polycystic ovary syndrome.
There is plentiful evidence that genetic factors have an important part to play in the etiology of polycystic ovary syndrome. As yet, however, none of the potential candidate loci have withstood the scrutiny of large case-control studies, although studies of a locus close to the insulin receptor gene on chromosome 19p are emerging as promising.
Franks
Stephen
S
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom. s.franks@imperial.ac.uk
D000328:Adult; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics
D011972:Receptor, Insulin