title: Margins and outcome of screen-detected breast cancer with extensive in situ component.
abstract: BACKGROUND
  In situ disease surrounding invasive tumours is an important consideration in the management of patients with early breast cancer. This study of screen-detected breast cancers assessed the influence of in situ disease including an extensive in situ component (defined as ductal carcinoma in situ involving more than 25% of the area within the invasive tumour) on surgical management, local recurrence and survival of a group of patients.
  
  
  METHODS
  A total of 595 cases of invasive breast cancer detected at St Vincent's BreastScreen were retrospectively reviewed to determine presence and extent of in situ disease, the surgical procedure and adequacy of excision. Outcome was examined in a cohort of 126 cases.
  
  
  RESULTS
  A total of 438 (74%) patients had in situ foci in or around the invasive tumour and 107 (18%) were defined as extensive in situ component (EIC)-positive. The initial procedure was mastectomy in 20% of the cases and breast-conserving surgery in 80% including 18% who underwent further surgery. Re-excision (P = 0.02) or mastectomy (P = 0.01) was more often required in patients with EIC. After definitive local excision, margins were close or involved with invasive disease in 3% but the patients with EIC were more likely to have margins close or involved with in situ disease (16 vs 2%; P = 0.001). There were seven deaths and one local invasive recurrence in the follow-up group and none of the deaths were in patients who were EIC-positive.
  
  
  CONCLUSIONS
  EIC predicts for a higher rate of re-excision and/or mastectomy. For patients with EIC, there is an acceptably low risk of local recurrence if margins are clear.
authors.affiliation: Department of Surgery, St Vincent's Hospital, Melbourne, Victoria, Australia. p.kitchen@unimelb.edu.au
authors.forename: Paul R B
authors.initials: PR
authors.lastname: Kitchen
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Cawson
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Moore
authors.forename: Prue A
authors.initials: PA
authors.lastname: Hill
authors.forename: Toni M
authors.initials: TM
authors.lastname: Barbetti
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Wilkins
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Power
authors.forename: Michael A
authors.initials: MA
authors.lastname: Henderson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome