Repression of secondary metabolite production by exogenous cAMP in Monascus.
The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.
Miyake
Tsuyoshi
T
Industrial Technology Center of Okayama Prefecture, Haga, Okayama. tsuyoshi_miyake@pref.okayama.jp
Zhang
Ming-Yong
MY
Kono
Isato
I
Nozaki
Nobuyuki
N
Sammoto
Hiroyuki
H
D000242:Cyclic AMP / Q000494:pharmacology*; D032741:Monascus / Q000187:drug effects* / Q000378:metabolism*; D015398:Signal Transduction
D000242:Cyclic AMP