Fluorescent measurement in the non-invasive contact lens glucose sensor.
BACKGROUND
The purpose of the present study was to determine the effectiveness of software in the hand-held photofluorometer permitting the monitoring of a second fluorescent signal to improve a contact lens glucose sensor for the non-invasive monitoring of glucose.


METHODS
One fasting normal patient was given an oral challenge consisting of 75 mL of Sustacol (Thomson Micromedex, Greenwood, CO). The two contact lens fluorescent signals and fingerstick blood glucose were measured over a 3-h period.


RESULTS
Subtracting the second fluorescent signal from the main signal produced a product that appeared to track blood glucose well. The contact lens was comfortable and well tolerated.


CONCLUSIONS
The biwavelength contact lens glucose sensor shows promise as a non-invasive home glucose monitor.
March
Wayne
W
Department of Ophthalmology, Downstate Medical Center, State University of New York, Brooklyn, New York 11203-2098, USA. WFMarch47@aol.com
Lazzaro
Douglas
D
Rastogi
Shobit
S
D003208:Concanavalin A; D003261:Contact Lenses; D003911:Dextrans; D005260:Female; D005452:Fluoresceins; D005947:Glucose / Q000032:analysis*; D006801:Humans; D020100:Hydrogels; D007908:Lens, Crystalline / Q000737:chemistry*; D008991:Monitoring, Physiologic / Q000379:methods; D013050:Spectrometry, Fluorescence
D003911:Dextrans; D005452:Fluoresceins; D020100:Hydrogels; C052526:fluorescein-dextran; D003208:Concanavalin A; D005947:Glucose