title: The effects of intradermal and topical mitomycin C on wound healing.
abstract: OBJECTIVE
  To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing.
  
  
  METHODS
  A prospective, controlled study in a rat wound model performed in an academic medical center.
  
  
  RESULTS
  Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months. Skin necrosis occurred in animals that received intradermal MMC. Hemotoxylin and eosin and immunohistochemical staining showed no consistent difference between treatment arms. Fibrosis and collagen deposition were reduced in MMC-treated wounds on trichrome staining.
  
  
  CONCLUSIONS
  MMC-treated wounds showed decreased wound strength compared with controls. Intradermal MMC can cause skin necrosis. Histologic findings did not always correspond with clinical data.
  
  
  CONCLUSIONS
  The data suggest cautious use of MMC in clinical situations when wound breaking strength is critical.
authors.affiliation: Mike O'Callaghan Federal Hospital, Nellis Air Force Base, NV 89191-6601, USA. glen.porter@nelis.af.mil
authors.forename: Glen T
authors.initials: GT
authors.lastname: Porter
authors.forename: Swarupa A
authors.initials: SA
authors.lastname: Gadre
authors.forename: Karen H
authors.initials: KH
authors.lastname: Calhoun
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D005500:Follow-Up Studies; D007150:Immunohistochemistry; D007271:Injections, Intradermal; D015552:Injections, Intralesional; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin