Study of danofloxacin depletion in eggs of laying hens after oral administration.
Danofloxacin was administered to 15 laying hens via drinking water for 12 days. Egg white and yolk from each egg were separated and danofloxacin residues were analysed by a high performance liquid chromatography method with fluorescence detection. Danofloxacin was detectable on the first day in egg white and on the second day in egg yolk after the beginning of administration, and higher danofloxacin residues accumulated in egg yolk than in egg white. Danofloxacin in egg white decreased fairly rapidly and was detectable up to 4 days after withdrawal of the drug. In egg yolk the residues declined slowly and were detectable up to 11 days after withdrawal of the drug.
Yang
Guixiang
G
South China Agricultural University, College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, Guangzhou, 510642 Guangdong, People's Republic of China.
Dong
Aiguo
A
Zeng
Zhenling
Z
Huang
Xianhui
X
Chen
Zhangliu
Z
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002645:Chickens / Q000254:growth & development*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D004529:Egg White / Q000032:analysis; D004530:Egg Yolk / Q000737:chemistry; D004531:Eggs / Q000032:analysis*; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C068581:danofloxacin