title: Immunizations for patients with metabolic disorders.
abstract: Individuals with underlying metabolic disorders are a potential high-risk group for vaccine-preventable diseases. Newborn metabolic screening has provided a means of early identification and treatment for many of these disorders, whereas childhood immunization is one of the most effective means of decreasing the morbidity and mortality resulting from communicable diseases worldwide. There are very few contraindications to the routine administration of vaccines to the healthy, immunocompetent individual. In certain high-risk groups, such as immunocompromised patients, gravid females, and those with a history of previous anaphylactic reaction to a vaccine or its components, selective withholding of immunizations must be considered to decrease potential adverse events. A detailed analysis of the medical literature revealed few specific recommendations regarding appropriate immunization techniques for patients with metabolic disorders. In this review we detail the major metabolic disorder subtypes, elaborate on the available literature on immunizations for patients with these disorders, and provide suggested vaccine recommendations.
authors.affiliation: Division of Pediatric Infectious Diseases, Creighton University Medical Center, Omaha, Nebraska 68131, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Kingsley
authors.forename: Meera
authors.initials: M
authors.lastname: Varman
authors.forename: Archana
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Rae A
authors.initials: RA
authors.lastname: Kingsley
authors.forename: Karl S
authors.initials: KS
authors.lastname: Roth
mesh_terms: D000293:Adolescent; D000592:Amino Acid Metabolism, Inborn Errors / Q000276:immunology / Q000628:therapy; D002239:Carbohydrate Metabolism, Inborn Errors / Q000276:immunology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D020022:Genetic Predisposition to Disease; D006801:Humans; D007114:Immunization / Q000379:methods; D007115:Immunization Schedule; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000235:genetics / Q000276:immunology; D007223:Infant; D007252:Influenza Vaccines; D008607:Intellectual Disability / Q000209:etiology / Q000235:genetics / Q000276:immunology; D008052:Lipid Metabolism, Inborn Errors / Q000276:immunology / Q000628:therapy; D008661:Metabolism, Inborn Errors / Q000145:classification / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000276:immunology / Q000628:therapy; D015164:Vaccines, Inactivated
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated