Mechanics and chemotaxis in the morphogenesis of vascular networks.
The formation of vascular networks in vitro develops along two rather distinct stages: during the early migration-dominated stage the main features of the pattern emerge, later the mechanical interaction of the cells with the substratum stretches the network. Mathematical models in the relevant literature have been focusing just on either of the aspects of this complex system. In this paper, a unified view of the morphogenetic process is provided in terms of physical mechanisms and mathematical modeling.
Tosin
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Politecnico di Torino, Dipartimento di Matematica, Corso Duca degli Abruzzi 24-10129 Torino, Italy. andrea.tosin@polito.it
Ambrosi
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Preziosi
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D000465:Algorithms; D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000502:physiology; D002452:Cell Count; D002465:Cell Movement / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D003094:Collagen; D004338:Drug Combinations; D004548:Elasticity; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007797:Laminin; D008954:Models, Biological; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011509:Proteoglycans
D004338:Drug Combinations; D007797:Laminin; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen