title: Effect of Pueraria mirifica on the sexual skin coloration of aged menopausal cynomolgus monkeys.
abstract: To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PM-feeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys.
authors.affiliation: Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
authors.forename: Hataitip
authors.initials: H
authors.lastname: Trisomboon
authors.forename: Suchinda
authors.initials: S
authors.lastname: Malaivijitnond
authors.forename: Wichai
authors.initials: W
authors.lastname: Cherdshewasart
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Taya
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D008252:Macaca fascicularis; D008593:Menopause; D048789:Phytoestrogens / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology*; D029908:Pueraria / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D012880:Skin Pigmentation
chemical_list: D048789:Phytoestrogens; D010936:Plant Extracts