title: Randomized open comparison of the safety of SLIT in a no-updosing and traditional updosing schedule in patients with Parietaria allergy.
abstract: BACKGROUND
  Due to optimal safety of sublingual immunotherapy (SLIT), it was suggested that a slow up-dosing phase maybe not necessary, and therefore the treatment will be more patient-friendly, avoiding dosing mistakes.
  
  
  METHODS
  Twenty adult patients suffering allergic rhinitis due to Parietaria, were enrolled. Half of them received the traditional schedule and the other half immediately started with 200 STU.
  
  
  RESULTS
  No difference was observed between the traditional up-dosing treatment schedule and no-up-dosing treatment schedule in terms of side effects, even mild local side effects, even mild local side effects was greater with traditional regimen.
authors.affiliation: Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Guerra
authors.forename: Enrico
authors.initials: E
authors.lastname: Compalati
authors.forename: Anthi
authors.initials: A
authors.lastname: Rogkakou
authors.forename: Silvia
authors.initials: S
authors.lastname: Pecora
authors.forename: Giovanni
authors.initials: G
authors.lastname: Passalacqua
authors.forename: Giorgio Walter
authors.initials: GW
authors.lastname: Canonica
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003888:Desensitization, Immunologic / Q000009:adverse effects* / Q000379:methods; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D008875:Middle Aged; D032403:Parietaria / Q000009:adverse effects* / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000209:etiology / Q000276:immunology / Q000628:therapy*
chemical_list: D000485:Allergens