title: Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema.
abstract: OBJECTIVE
  To investigate the global cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical features.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  In 31 aqueous humor samples from uveitis patients, the concentration of mediators was measured by a multiplex immunoassay. Eleven control samples were included.
  
  
  RESULTS
  Uveitis samples had higher levels of interleukin-6, interleukin-8, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule (sVCAM), and interferon-inducible protein-10 (IP-10) than nonuveitis controls. Active uveitis samples had higher levels of interleukin-6, interleukin-10, interferon-gamma, sVCAM, regulated on activation, normal T cell expressed and secreted (RANTES), and IP-10 than quiescent uveitis samples. Infectious uveitis was associated with higher levels of interleukin-10 than noninfectious uveitis (P < .03 for all subgroups). No significant differences were found between cystoid macular edema (CME) and non-CME samples.
  
  
  CONCLUSIONS
  Elevated levels of specific mediators were found in active and in infectious uveitis, but not in CME. Mediator profiles might lead to a better understanding of the pathogenesis of uveitis.
authors.affiliation: F. C. Donders Institute of Ophthalmology, Utrecht, The Netherlands. b.vankooij@oogh.azu.nl
authors.forename: Bram
authors.initials: B
authors.lastname: van Kooij
authors.forename: Aniki
authors.initials: A
authors.lastname: Rothova
authors.forename: Ger T
authors.initials: GT
authors.lastname: Rijkers
authors.forename: Jolanda D F
authors.initials: JD
authors.lastname: de Groot-Mijnes
mesh_terms: D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008269:Macular Edema / Q000378:metabolism*; D008875:Middle Aged; D014605:Uveitis / Q000378:metabolism*
chemical_list: D018925:Chemokines; D016207:Cytokines