Catalytic asymmetric synthesis of alpha- and beta-amino phosphonic acid derivatives.
Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding alpha- and beta-amino acids, optically active alpha- and beta-amino phosphonic acid derivatives have found widespread use in medicinal chemistry and the pharmaceutical sciences. Using catalytic amounts of chiral materials, asymmetric synthesis of enantiomerically enriched alpha- and beta-amino phosphonates has been a subject of growing interest. This tutorial review contains a compilation of the catalytic asymmetric synthetic methods developed to date and highlights their utility for obtaining these target compounds.
Ma
Jun-An
JA
Department of Chemistry, Tianjin University, Tianjin, 300072, China. majun_an68@tju.edu.cn
D002384:Catalysis; D007097:Imines / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D007097:Imines; D008024:Ligands; D063065:Organophosphonates