Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study.
In this study, a newly reported regional homogeneity approach was used to analyze blood oxygen level-dependent functional magnetic resonance imaging data on resting state in boys with attention deficit hyperactivity disorder. Boys with attention deficit hyperactivity disorder showed decreased regional homogeneity in the frontal-striatal-cerebellar circuits, but increased regional homogeneity mainly in the occipital cortex. Our findings are consistent with the hypothesis of abnormal frontal-striatal-cerebellar circuits in attention deficit hyperactivity disorder. The regional homogeneity approach may be a potentially useful method in exploring the pathophysiology of attention deficit hyperactivity disorder.
Cao
Qingjiu
Q
Institute of Mental Health, Peking University, Beijing, PR China.
Zang
Yufeng
Y
Sun
Li
L
Sui
Manqiu
M
Long
Xiangyu
X
Zou
Qihong
Q
Wang
Yufeng
Y
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology*; D001921:Brain / Q000002:abnormalities* / Q000098:blood supply* / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology*
D010100:Oxygen