Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials.
Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.
Balas
Francisco
F
Departamento de Química Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Manzano
Miguel
M
Horcajada
Patricia
P
Vallet-Regí
María
M
D000327:Adsorption; D019386:Alendronate / Q000737:chemistry*; D050071:Bone Density Conservation Agents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
D050071:Bone Density Conservation Agents; D004337:Drug Carriers; D063065:Organophosphonates; D012822:Silicon Dioxide; D019386:Alendronate