[Neuronal migration disorders: a cause of curable medication resistant epilepsy].
BACKGROUND
Focal cortical dysplasia is a neuronal migration disorder that appears with bouts of epileptic seizures that are usually medication resistant. The improvements introduced into neuroimaging techniques in recent years have made it possible to diagnose and offer surgical treatment to certain patients who have been under polytherapy for many years with poor control over their seizures.


METHODS
We report the case of a 22-year-old male with epileptic fits since the age of 18 months, who was refractory to multiple combinations of oral antiepileptic drugs (AEDs) with electroencephalograms that displayed frontal, fast spike-wave discharges, with greater expression on the left side and findings from neuroimaging techniques that were repeatedly normal. After being readmitted to hospital because his seizures had got worse, the neuroimaging study was repeated and left frontal focal cortical dysplasia was observed, which led us to start considering neurosurgery. At present, six months after the intervention, the patient has had no further convulsive fits and therapy with oral AEDs is being reduced.


CONCLUSIONS
Neuroimaging studies must be repeated in patients that have already been examined because in this way it may be possible to save a group of patients (who would otherwise have to resign to poor control over their seizures as well as the side effects of many AEDs) from becoming medication resistant.
Piñol-Ripoll
G
G
Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. gerard_437302@hotmail.com
Mauri-Llerda
J A
JA
Rumià
J
J
Carreño
M
M
de la Puerta González-Miró
I
I
Mostacero-Miguel
E
E
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001927:Brain Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement / Q000502:physiology*; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology*
D000927:Anticonvulsants