Effect of Pueraria mirifica on the sexual skin coloration of aged menopausal cynomolgus monkeys.
To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PM-feeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys.
Trisomboon
Hataitip
H
Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
Malaivijitnond
Suchinda
S
Cherdshewasart
Wichai
W
Watanabe
Gen
G
Taya
Kazuyoshi
K
D000375:Aging; D000818:Animals; D005260:Female; D008252:Macaca fascicularis; D008593:Menopause; D048789:Phytoestrogens / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology*; D029908:Pueraria / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D012880:Skin Pigmentation
D048789:Phytoestrogens; D010936:Plant Extracts