Ectonucleotidases in the nervous system.
Extracellular nucleotides are hydrolysed by enzymes of the plasma membrane with an extracellularly oriented catalytic site (ectonucleotidases). Members of several families of ectonucleotidases can contribute to extracellular nucleotide hydrolysis. They have been characterized in molecular and functional terms. A major role of these enzymes is in the modulation of ligand availability at nucleotide and nucleoside receptors. The enzymes reveal a wide and partially overlapping tissue distribution. The diversity of the individual family members is considerable and it is still difficult to assign identified enzymes to the modulation of purinergic signalling pathways. In the brain, members of all ectonucleotidase-families are expressed. Proposed physiological functions include modulation of synaptic transmission, of the ATP-mediated propagation of glial Ca2+ waves, of microglial function, adult neurogenesis or the control of vascular tone, haemostasis and thromboregulation.
Zimmermann
Herbert
H
Biozentrum der J W Goethe-Universität, AK Neurochemie, Frankfurt am Main, Germany.
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D001081:Apyrase / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D001808:Blood Vessels / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009024:Morphogenesis; D009420:Nervous System / Q000201:enzymology*; D009457:Neuroglia / Q000201:enzymology / Q000502:physiology; D009474:Neurons / Q000201:enzymology / Q000502:physiology; D009711:Nucleotides / Q000378:metabolism*; D010802:Phylogeny; D011487:Protein Conformation; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D015703:Antigens, CD; D007527:Isoenzymes; D008565:Membrane Proteins; D009711:Nucleotides; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2; D001081:Apyrase; C067869:CD39 antigen