[MxA gene-88 G/T polymorphism influences the outcomes of HBV infection].
OBJECTIVE
To study the relationship between a G/T substitution at position -88 of myxovirus resistance-1 gene (MxA) and the self-limiting or chronic infection of HBV.


METHODS
Blood samples from 100 patients with self-limiting HBV infection (positive anti-HBs and anti-HBc) and from 340 patients with chronic HBV infection were collected. MxA-88 G/T polymorphism was typed using a protocol based on competitively differentiated-polymerase chain reaction. For statistical analysis, odds ratio and chi-square test were used.


RESULTS
The detective rate of G/G genotype (low expression genotype) of MxA-88 G/T was 50.2% (221/440), those of T/T genotype (high expression genotype) and G/T heterozygous genotype were 5.5% (24/440) and 44.3% (195/440). Compared to patients with chronic infection, patients with self-limiting infection had lower frequency of G/G genotype (41.0% vs 52.9%, P < 0.05) or G allele (62.5% vs 75.9%, P < 0.01) and had higher frequency of T/T genotype (16.0% vs 2.4%, P < 0.01) or T allele (37.5% vs 24.1%, P < 0.01), but there was no significant difference in the G/T heterozygous genotype.


CONCLUSIONS
MxA gene -88 G/T polymorphism influences the natural outcomes of HBV infection to some extent. This SNP of MxA gene may be used as a clinical prognostic marker of HBV infection.
Yin
Si-chun
SC
Department of Infectious Diseases, Peopleos Hospital of Dongguan, Dongguan 523018, China. yinsichun@hotmail.com
Peng
Xiao-mou
XM
Gu
Lin
L
Huang
Yang-su
YS
Gao
Zhi-liang
ZL
D000328:Adult; D015415:Biomarkers; D005260:Female; D019204:GTP-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D064547:Myxovirus Resistance Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis
D015415:Biomarkers; C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins