Nucleophosmin and cancer.
NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis.
Grisendi
Silvia
S
Cancer Biology & Genetics Program, Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Mecucci
Cristina
C
Falini
Brunangelo
B
Pandolfi
Pier Paolo
PP
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000090243:Nucleophosmin; D000090063:Proto-Oncogene Mas
C000715470:MAS1 protein, human; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090063:Proto-Oncogene Mas; D000090243:Nucleophosmin