title: Enantioselective radical reactions. Evaluation of nitrogen protecting groups in the synthesis of beta-amino acids.
abstract: We have investigated the effect of nitrogen protecting groups in radical addition trapping experiments leading to beta(2)-amino acids. Of the three N-protecting groups examined, the phthalimido group was optimal with respect to both yields and enantioselectivity. Additionally, radical additions to more complex acrylates were also investigated, which provided access to functionalized beta(2)-amino acids in modest selectivity.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA.
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
authors.forename: Kalyani
authors.initials: K
authors.lastname: Patil