Antibacterial cobalt (II), copper (II), nickel (II) and zinc (II) complexes of mercaptothiadiazole--derived furanyl, thienyl, pyrrolyl, salicylyl and pyridinyl Schiff bases.
A series of Co (II), Cu (II), Ni (II) and Zn (II) complexes of mercaptothiadiazole-derived furanyl, thienyl, pyrrorlyl, salicylyl and pyridinyl Schiff bases were synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella fexneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureous bacterial strains. The results of these studies show the metal complexes to be more antibacterial as compared to the prepared un-complexed Schiff bases.
Chohan
Zahid H
ZH
Department of Chemistry, Bahauddin Zakariya University, Multan 60800, Pakistan. zchohan@mul.paknet.com.pk
Pervez
Humayun
H
Rauf
Abdul
A
Khan
Khalid M
KM
Supuran
Claudiu T
CT
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004553:Electric Conductivity; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005663:Furans; D019216:Metals, Heavy; D011758:Pyrroles; D012545:Schiff Bases; D013438:Sulfhydryl Compounds; D013830:Thiadiazoles; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc