[Forecasting parameters of acute chemical toxicity according to in vitro conformation changes of proteins].
The authors analyze experimental data on in vitro effects induced by chemicals that were used throughout MEIC toxicologic studies in ovalbumin and acetylcholinesterase of human RBC. Influence on proteins is compared to acute toxicity caused by the chemicals in humans and various cell lines. The conclusion is that the method is prospective for screening of acute chemical toxicity signs in humans.
Luk'ianov
A S
AS
Semina
T K
TK
Korolev
A M
AM
D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D003485:Cyanates / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity; D008294:Malathion / Q000633:toxicity; D009538:Nicotine / Q000633:toxicity; D010047:Ovalbumin / Q000187:drug effects / Q000378:metabolism*; D011042:Poisons / Q000633:toxicity*
D003485:Cyanates; D007306:Insecticides; D011042:Poisons; D009538:Nicotine; D010047:Ovalbumin; D000110:Acetylcholinesterase; C024835:potassium cyanate; D008294:Malathion