CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Kaul
Sunil C
SC
National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan. s-kaul@aist.go.jp
Hasan
Kamrul
K
Wadhwa
Renu
R
D000818:Animals; D016922:Cellular Senescence; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D025803:Tumor Suppressor Protein p14ARF / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D050759:Cyclin-Dependent Kinase Inhibitor p21; D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53