title: A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival.
abstract: Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.
authors.affiliation: Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583-0963, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: David
authors.initials: D
authors.lastname: Pot
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Kachman
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Nuzhdin
authors.forename: Lawrence G
authors.initials: LG
authors.lastname: Harshman
mesh_terms: D000367:Age Factors; D000818:Animals; D030801:Animals, Genetically Modified; D017849:Animals, Inbred Strains; D002874:Chromosome Mapping / Q000379:methods; D004330:Drosophila / Q000235:genetics*; D005260:Female; D005298:Fertility / Q000235:genetics; D014644:Genetic Variation; D016013:Likelihood Functions; D008297:Male; D010063:Ovum / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics*; D011156:Population Density; D011336:Probability; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D012727:Sex Characteristics; D016019:Survival Analysis