title: Modification of the clozapine structure by parallel synthesis.
abstract: A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D(1)-selective and D(2)-selective compounds can be obtained.
authors.affiliation: Department of Chemical Research, Schering-Plough Research Institute K15 2545, Kenilworth, NJ 07033, USA. jing.su@spcorp.com
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Haiqun
authors.initials: H
authors.lastname: Tang
authors.forename: Brian A
authors.initials: BA
authors.lastname: McKittrick
authors.forename: Duane A
authors.initials: DA
authors.lastname: Burnett
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhang
authors.forename: April
authors.initials: A
authors.lastname: Smith-Torhan
authors.forename: Ahmad
authors.initials: A
authors.lastname: Fawzi
authors.forename: Jean
authors.initials: J
authors.lastname: Lachowicz
mesh_terms: D003024:Clozapine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D015394:Molecular Structure; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D003024:Clozapine