title: Decreased creatine kinase activity caused by electroconvulsive shock.
abstract: Although several advances have occurred over the past 20 years concerning the use and administration of electroconvulsive therapy to minimize side effects of this treatment, little progress has been made in understanding its mechanism of action. Creatine kinase is a crucial enzyme for brain energy homeostasis, and a decrease of its activity has been associated with neuronal death. This work was performed in order to evaluate creatine kinase activity from rat brain after acute and chronic electroconvulsive shock. Results showed an inhibition of creatine kinase activity in hippocampus, striatum and cortex, after acute and chronic electroconvulsive shock. Our findings demonstrated that creatine kinase activity is altered by electroconvulsive shock.
authors.affiliation: Laboratório de Bioquímica Experimental, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
authors.forename: Márcio
authors.initials: M
authors.lastname: Búrigo
authors.forename: Clarissa A
authors.initials: CA
authors.lastname: Roza
authors.forename: Cintia
authors.initials: C
authors.lastname: Bassani
authors.forename: Gustavo
authors.initials: G
authors.lastname: Feier
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Streck
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D003402:Creatine Kinase / Q000378:metabolism*; D004565:Electroconvulsive Therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003402:Creatine Kinase