title: Neurogenesis in the adult central nervous system.
abstract: Contrary to the long-held dogma, neurogenesis occurs throughout adulthood, and neural stem cells reside in the adult central nervous system (CNS) in mammals. The developmental process of the brain may thus never end, and the brain may be amenable to repair. Neurogenesis is modulated in a wide variety of physiological and pathological conditions, and is involved in processes such as learning and memory and depression. However, the relative contribution of newly generated neuronal cells to these processes, as well as to CNS plasticity, remains to be determined. Thus, not only neurogenesis contributes to reshaping the adult brain, it will ultimately lead us to redefine our knowledge and understanding of the nervous system.
authors.affiliation: National Neuroscience Institute, Singapore, 11 Jalan Tan Tock Seng, Singapore 308433. obgpjt@nus.edu.sg
authors.forename: Philippe
authors.initials: P
authors.lastname: Taupin
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000503:physiopathology; D006801:Humans; D008322:Mammals; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005680:gamma-Aminobutyric Acid