title: Perinatal stroke in twins without co-twin demise.
abstract: Perinatal stroke in twins without co-twin demise has not been well-described. In this study, the International Classification of Diseases- 9th edition code searches and medical record review were used to identify all children with arterial ischemic stroke examined in a pediatric stroke clinic over a 2-year period. Four of the 35 children (11.4%) with perinatal arterial ischemic stroke were twins; none had co-twin demise. No co-twin had any clinical evidence of perinatal stroke. The most common findings on prothrombotic evaluation were elevated antiphospholipid antibodies (2), elevated lipoprotein a (2), and elevated Factor VIIIc (2). Twin gestation without co-twin demise may be a risk factor for perinatal stroke, and might help explain the higher incidence of cerebral palsy in twins.
authors.affiliation: Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. mgolomb@iupui.edu
authors.forename: Meredith R
authors.initials: MR
authors.lastname: Golomb
authors.forename: Linda S
authors.initials: LS
authors.lastname: Williams
authors.forename: Bhuwan P
authors.initials: BP
authors.lastname: Garg
mesh_terms: D002675:Child, Preschool; D004200:Diseases in Twins / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology*