Intracoronary injection of granulocyte colony-stimulating factor ameliorates the progression of left ventricular remodeling after myocardial ischemia/reperfusion in rabbits.
BACKGROUND
Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown.


RESULTS
A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection.


CONCLUSIONS
Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.
Hasegawa
Hiroshi
H
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Takano
Hiroyuki
H
Shiraishi
Hirokazu
H
Ueda
Kazutaka
K
Niitsuma
Yuriko
Y
Tadokoro
Hiroyuki
H
Komuro
Issei
I
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004452:Echocardiography; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications; D011817:Rabbits; D011994:Recombinant Proteins; D020257:Ventricular Remodeling / Q000187:drug effects*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor