title: The neurobiology of neurooncology.
abstract: The histological classification of brain tumors currently is based on the morphological appearance and protein expression patterns that reflect specific cell types within the central nervous system. Recent studies have suggested that the cells of origin for brain tumors may persist in the fully formed tumors, and that these "cancer stem cells" might represent the relevant cellular targets for anticancer therapy. In this regard, insights into the developmental neurobiology of brain tumors has significant impact on our understanding of the molecular and cellular pathogenesis of these devastating cancers, as well as the development of new strategies for treating brain tumors.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Tracy-Ann
authors.initials: TA
authors.lastname: Read
authors.forename: Balazs
authors.initials: B
authors.lastname: Hegedus
authors.forename: Robert
authors.initials: R
authors.lastname: Wechsler-Reya
authors.forename: David H
authors.initials: DH
authors.lastname: Gutmann
mesh_terms: D001254:Astrocytoma / Q000145:classification / Q000209:etiology / Q000473:pathology*; D001932:Brain Neoplasms / Q000145:classification / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008527:Medulloblastoma / Q000145:classification / Q000209:etiology / Q000473:pathology*; D009446:Neurobiology