title: Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report.
abstract: BACKGROUND
  A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine.
  
  
  METHODS
  The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.
  
  
  RESULTS
  Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed.
  
  
  CONCLUSIONS
  The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
authors.affiliation: Institute of Biomedicine, Ministry of Health and Social Development and Central University of Venezuela, Caracas, Venezuela. ozerpa@telcel.net.ve
authors.forename: Olga
authors.initials: O
authors.lastname: Zerpa
authors.forename: Belkys
authors.initials: B
authors.lastname: Blanco
authors.forename: Carmen
authors.initials: C
authors.lastname: Kannee
authors.forename: Marian
authors.initials: M
authors.lastname: Ulrich
authors.forename: Herbert
authors.initials: H
authors.lastname: Sindermann
authors.forename: Juergen
authors.initials: J
authors.lastname: Engel
authors.forename: Jacinto
authors.initials: J
authors.lastname: Convit
mesh_terms: D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014860:Warts / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine