title: Metastatic adenocarcinoma of prostate in a healing sternotomy site.
abstract: Metastatic prostate cancer has a strong predilection for osseous sites, where the disease spreads in 80% of advanced cases. The molecular mechanisms involved in prostate cancer establishment in bone are largely unknown; however, local tissue factors, including those involved in wound healing, have been suggested to play a critical role. We present a case of tumor explosion in a median sternotomy wound after local prostate cancer therapy. This case highlights that novel therapeutic interventions that disrupt the apparent synergistic relationship between tumor cells and the pro-tumorigenic microenvironment may hold great promise in constraining the proliferation of prostate cancer metastases.
authors.affiliation: Division of Urology and Renal Transplantation, Oregon Health and Science University, Portland, Oregon, USA.
authors.forename: Greg
authors.initials: G
authors.lastname: Adams
authors.forename: Amanda
authors.initials: A
authors.lastname: Mitchell
authors.forename: Ravi
authors.initials: R
authors.lastname: Ravichandran
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Beer
authors.forename: Mark
authors.initials: M
authors.lastname: Garzotto
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D001026:Coronary Artery Bypass; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D013249:Sternum / Q000601:surgery*; D014945:Wound Healing