title: Cerebral ischemic attack secondary to hepatitis C virus infection.
abstract: Hepatitis virus C (HCV) is worldwide a health problem, which may lead to serious complications. The aim of this study was to correlate the onset of the cerebral ischemic attack accompanied by mixed cryoglobulinemia, with the chronic hepatitis C virus infection. These studies were carried out in 12 patients with serologic/virusologic confirmed chronic HCV infection associated with ischemic stroke. Ischemic stroke occurred in equal proportion in women and men. The patients did not know of HCV infection diagnosis at that moment. All patients had type II mixed monoclonal cryoglobulinemia, hypergammaglobulinemia with polyclonal IgG and monoclonal IgM, blood hyperviscosity, high level of cryocrit, positive rheumatoid factor, normal levels of serum transaminases, negative serum hepatitis B surface antigen (HBs Ag), negative anti HBc antibodies, positive HCV antibodies, positive serum RNA HCV, decreased serum C3 and C4 levels, antinuclear antibodies-false positive. Immunological tests for autoantibodies, namely, anti-Sm antibody, anti-RNP antibody, anti-SS-A and -B antibodies, and anti-Scl antibody were not detectable due to high level serum cryoglobulin. Cryoglobulin was washed several times with an isotonic chloride solution for purification, then subject to immunological analyses. The purified cryoglobulin contained monoclonal IgM-kappa, polyclonal IgG. Cryoglobulinemia is a risk factor for ischemic stroke, as it causes arterial thrombosis.
authors.affiliation: Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest Romania. mcojocar@cmb.ro
authors.forename: Inimioara Mihaela
authors.initials: IM
authors.lastname: Cojocaru
authors.forename: M
authors.initials: M
authors.lastname: Cojocaru
authors.forename: Simona Alexandra
authors.initials: SA
authors.lastname: Iacob
authors.forename: Cecilia
authors.initials: C
authors.lastname: Burcin
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis* / Q000821:virology*; D003449:Cryoglobulinemia / Q000150:complications / Q000821:virology*; D003450:Cryoglobulins / Q000032:analysis*; D005260:Female; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003450:Cryoglobulins; D018937:Hepatitis C Antibodies