title: Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.
abstract: The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.
authors.affiliation: Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium. Robert.Snoeck@rega.kuleuven.be.
authors.forename: Ilya
authors.initials: I
authors.lastname: Lebeau
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Fabiana
authors.initials: F
authors.lastname: Dal Pozzo
authors.forename: James R
authors.initials: JR
authors.lastname: Beadle
authors.forename: Karl Y
authors.initials: KY
authors.lastname: Hostetler
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Joost
authors.initials: J
authors.lastname: van den Oord
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D000077404:Cidofovir; D003500:Cyclization; D003588:Cytopathogenic Effect, Viral; D003596:Cytosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004952:Esters; D005347:Fibroblasts / Q000821:virology*; D006801:Humans; D015603:Keratinocytes / Q000821:virology*; D063065:Organophosphonates / Q000737:chemistry* / Q000494:pharmacology*; D018155:Orthopoxvirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004952:Esters; D063065:Organophosphonates; D003596:Cytosine; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D000225:Adenine; D000077404:Cidofovir