title: Prognosis of lupus membranous nephropathy in children.
abstract: The occurrence of membranous nephropathy in pediatric series of systemic lupus erythematosus has been reported only rarely, probably due to a very low frequency. One hundred fifty-four children who were seen in 100 French pediatric centers between January 2002 and April 2005 were included. Fifteen (12 girls and three boys) out of the 81 (18.5 %) children with renal involvement presented histological features of membranous nephropathy. Their ages ranged from six to 15 years old (mean=11.3) at the age of SLE diagnosis and 8/15 children were of African origin. Isolated membranous nephropathy was observed in nine patients, of whom five patients displayed a complete recovery following immunosuppressive treatment. Associated proliferative lesions were observed on the first kidney specimen in two patients and in a further renal biopsy in four other patients, leading to a less favorable course of lupus nephropathy.
authors.affiliation: Pediatric Unit, Hôpital Mignot, 177 rue de Versailles, 78150, le Chesnay, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Nathanson
authors.forename: Rémi
authors.initials: R
authors.lastname: Salomon
authors.forename: Bruno
authors.initials: B
authors.lastname: Ranchin
authors.forename: Marie-Alice
authors.initials: MA
authors.lastname: Macher
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Lavocat
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Krier
authors.forename: Véronique
authors.initials: V
authors.lastname: Baudouin
authors.forename: Christine
authors.initials: C
authors.lastname: Azéma
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bader-Meunier
authors.forename: Georges
authors.initials: G
authors.lastname: Deschênes
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D011379:Prognosis