title: Cystic beta2-microglobulin amyloidoma in a patient on long-term hemodialysis.
abstract: We report a patient with beta2 microglobulin amyloidosis (beta2M) in whom cystic tumors were seen in the bilateral axillary region. The patient was a 68-year-old woman who had been on hemodialysis for more than 20 years because of IgA nephropathy. Computed tomography-guided biopsy was performed to confirm the diagnosis. Congo red staining, beta2M immunohistochemistry, and electron microscopy examination of the biopsied sample showed extended beta2M deposits in the cystic tumor. beta2M-related amyloidosis in patients with long-term dialysis commonly presents as osteoarticular disease, although a soft-tissue pseudotumor, known as amyloidoma, has been reported. This is the first report in the English-language literature of amyloidosis presenting as bilateral axillary cystic tumors.
authors.affiliation: Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, Yokohama 224-8503, Japan. ogatah@med.showa-u.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ogata
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Koiwa
authors.forename: Junko
authors.initials: J
authors.lastname: Takahashi
authors.forename: Ken
authors.initials: K
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Shiokawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitanosono
authors.forename: Eriko
authors.initials: E
authors.lastname: Kinugasa
authors.forename: Susumu
authors.initials: S
authors.lastname: Taguchi
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D001365:Axilla / Q000473:pathology; D003560:Cysts / Q000209:etiology*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000628:therapy*; D006801:Humans; D006435:Renal Dialysis / Q000009:adverse effects*; D001613:beta 2-Microglobulin / Q000276:immunology
chemical_list: D001613:beta 2-Microglobulin