Elucidation of chiral recognition processes of macrocyclic antibiotic vancomycin.
A theoretical investigation was carried out on the retention and separation of enantiomeric molecules including nonsteroidal anti-inflammatory drugs, anti-neoplastic compounds and N-derivatized amino acids by capillary electrophoresis using macrocyclic antibiotics, a new class of chiral selectors, as stationary phase. Firstly docking methods were used to study the enantiorecognition in chiral electrophoresis. The molecular dynamics simulations of the two diastereoisomer complexes were then performed in order to understand how these antibiotics recognize the enantiomers. Another approach was applied in this study to establish a quantitative structure-enantioselectivity relationship (QSER) model, able to describe the resolution of a series of chiral compounds in capillary electrophoresis using vancomycin as the resolving agent.
Bauvais
C
C
ITODYS, CNRS UMR 7086, Université Paris 7 - Denis Diderot, 1 rue Guy de la Brosse, 75005, Paris, France.
Barbault
F
F
Zhu
Y
Y
Petitjean
M
M
Fan
B T
BT
D000900:Anti-Bacterial Agents / Q000737:chemistry; D019075:Electrophoresis, Capillary; D008958:Models, Molecular; D016571:Neural Networks, Computer; D021281:Quantitative Structure-Activity Relationship; D013237:Stereoisomerism; D014640:Vancomycin / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D014640:Vancomycin