Phosphoinositide regulation of neuroexocytosis: adding to the complexity.
Exocytosis of neurotransmitter containing vesicles supports neuronal communication. The importance of molecular interactions involving specific lipids has become progressively more evident and the lipid composition of both the synaptic vesicle and the pre-synaptic plasma membrane at the active zone has significant functional consequences for neurotransmitter release. Several classes of lipids have been implicated in exocytosis including polyunsaturated fatty acids and phosphoinositides. This minireview will focus on recent developments regarding the role of phosphoinositides in neurosecretion.
Osborne
Shona L
SL
Molecular Dynamics of Synaptic Function Laboratory, School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.
Wen
Peter J
PJ
Meunier
Frederic A
FA
D000818:Animals; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D010716:Phosphatidylinositols