title: Chlorhexidine-containing chewing gum. Clinical documentation.
abstract: A clinical documentation on chlorhexidine containing chewing gum is presented on the occasion of the launch of CHewX, a chewing gum containing 5 mg of chlorhexidine diacetate in Switzerland. Following an overview on functional chewing gum, the mechanism of action of chlorhexidine (CHX), its toxicity and safety are summarized and a review of clinical studies performed with CHX-containing chewing gum given. Indication, dosage, precautions and benefits of CHX chewing gum are described.
authors.affiliation: Klinik für Präventivzahnmedizin, Parodontologie und Kariologie, Zentrum für Zahn-, Mund- und Kieferheilkunde, Universität Zürich. thomas.imfeld@zzmk.unizh.ch
authors.forename: Thomas
authors.initials: T
authors.lastname: Imfeld
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D002638:Chewing Gum; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D006224:Cricetinae; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D014075:Tooth Discoloration / Q000139:chemically induced
chemical_list: D000891:Anti-Infective Agents, Local; D002638:Chewing Gum; D002710:Chlorhexidine