An evolutionary concept of polycystic ovarian disease: does evolution favour reproductive success over survival?
Polycystic ovarian disease (PCOD) is currently considered as possibly the most frequent cause of female infertility. It is also closely associated with syndrome XX, which, in turn, is closely linked with premature and excessive mortality. Considering these adverse effects on reproductive success and human survival, the evolutionary survival of PCOD, itself considered by many to be a genetically transmitted condition, would, on first glance, appear surprising, since evolution usually discriminates against both of these traits. However, an analysis of some recently reported characteristics of the condition calls for the reconsideration of PCOD as a condition which, from an evolutionary viewpoint, favours decreased reproductive success. Indeed, the reported observations that patients with PCOD will resume spontaneous ovulation with even relatively minor weight loss, and experience later menopause than controls, suggests exactly the opposite. Under an evolutionary concept, PCOD can thus be seen as a 'fertility storage condition' which in fact favours human reproductive success and allows the human species to maintain fertility even during adverse environmental circumstances, such as famines.
Gleicher
Norbert
N
Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA. ngleicher@thechr.com
Barad
David
D
D000858:Anovulation; D005075:Biological Evolution; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D009865:Oocytes / Q000502:physiology; D010053:Ovary / Q000502:physiology / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D012098:Reproduction / Q000502:physiology*; D012959:Socioeconomic Factors; D015431:Weight Loss