Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.
One of the pathways to polycystic ovary syndrome (PCOS) starts with an early-life sequence of prenatal growth restraint followed by catch-up of weight during infancy. This sequence results by mid-childhood in a pre-PCOS state including hyperinsulinemia, a low-grade proinflammatory state, an amplified adrenarche (with or without precocious pubarche), and an adipose body composition even in the absence of obesity. This variant of pre-PCOS and PCOS responds well to intervention with metformin.
de Zegher
Francis
F
Department of Woman and Child, University of Leuven, Leuven, Belgium.
Ibáñez
Lourdes
L
D000375:Aging; D000726:Androgen Antagonists / Q000627:therapeutic use; D001835:Body Weight; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D047109:Fetal Development; D020567:Fetal Weight; D005485:Flutamide / Q000627:therapeutic use; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn / Q000254:growth & development*; D008687:Metformin / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000209:etiology*; D011629:Puberty, Precocious / Q000209:etiology
D000726:Androgen Antagonists; D007004:Hypoglycemic Agents; D005485:Flutamide; D008687:Metformin