title: Laparoscopic management of insulinoma in a child with multiple endocrine neoplasia type 1.
abstract: The diagnosis and surgical management of insulinomas associated with multiple endocrine neoplasia type 1 (MEN1) pose additional problems in children because of the long-term risk of recurrence of other pancreatic and non-pancreatic tumors. We report a diagnostic confirmation by laparoscopic ultrasound of an insulinoma and its successful removal by laparoscopic enucleation in an 8- year-old boy who was admitted to our hospital with a history of recurrent episodes of absences, headache, and visual and auditive disturbances diagnosed as hyperinsulinism-related hypoglycemia. Magnetic resonance imaging of the pancreas showed a small contrast-enhancing lesion in the body of the pancreas, suspected for insulinoma. MEN1 was genetically proven by direct DNA testing. A pancreatic tumor can arise before the age of 10 in patients with MEN1 and can be surgically treated by a laparoscopical approach.
authors.affiliation: Department of Surgery, Vrije Universiteit Brussel, Brussels, Belgium. hlkdvek@az.vub.ac.be
authors.forename: Kristel
authors.initials: K
authors.lastname: de Vogelaere
authors.forename: Jean
authors.initials: J
authors.lastname: De Schepper
authors.forename: Marjan
authors.initials: M
authors.lastname: Vanhoeij
authors.forename: Johan
authors.initials: J
authors.lastname: De Mey
authors.forename: Anita
authors.initials: A
authors.lastname: Goossens
authors.forename: Jesse
authors.initials: J
authors.lastname: Vanbesien
authors.forename: Antoine
authors.initials: A
authors.lastname: De Backer
authors.forename: Georges
authors.initials: G
authors.lastname: Delvaux
mesh_terms: D002648:Child; D003952:Diagnostic Imaging; D006801:Humans; D007340:Insulinoma / Q000473:pathology* / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery*