title: Polycytella hominis is a mutated form of Scedosporium apiospermum.
abstract: PCR amplification and sequencing of two separate regions of the nuclear ribosomal repeat region revealed that Polycytella hominis, a hyphomycete isolated from a human case of mycetoma, was genetically indistinguishable from Scedosporium apiospermum (the anamorph of Pseudallescheria boydii). These organisms also exhibited remarkably similar susceptibility profiles to common antifungal agents. P. hominis is thus likely to be a mutant of S. apiospermum showing abnormalities of sporulation, for which a possible mechanism is discussed. Polycytella hominis should thus be regarded as a synonym of Scedosporium apiospermum.
authors.affiliation: Mycology Reference Laboratory, Health Protection Agency South-West Regional Laboratory Myrtle Road, Bristol, UK. Andy.Borman@ubht.swest.nhs.uk
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Borman
authors.forename: Colin K
authors.initials: CK
authors.lastname: Campbell
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Linton
authors.forename: Paul D
authors.initials: PD
authors.lastname: Bridge
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Johnson
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D003904:Mitosporic Fungi / Q000145:classification* / Q000166:cytology / Q000187:drug effects / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D021681:Scedosporium / Q000145:classification* / Q000166:cytology / Q000187:drug effects / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013172:Spores, Fungal / Q000235:genetics
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal