Triterpenoid saponins from the fruits of Caryocar villosum.
Fourteen new triterpenoid saponins (1-14) were isolated from the methanol extract of the fruits of Caryocar villosum along with 10 known saponins. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, TOCSY, ROESY, HSQC, and HMBC) and ESIMS studies. The toxicity of the methanolic extracts of the peel and the pulp of fruits and the crude saponin fraction of the peel was assessed using the Artemia salina test. The antimicrobial activities of caryocarosides IV-21 (14), II-1 (16), III-1 (17), and IV-9 (20) and of saponin 23 were also studied in vitro on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Mycobacterium smegmatis, and Enterococcus faecalis bacteria.
Alabdul Magid
Abdulmagid
A
Laboratoire de Pharmacognosie, FRE CNRS 2715, IFR 53 Biomolécules, Bâtiment 18, BP 1039, 51687 Reims Cedex 2, France.
Voutquenne
Laurence
L
Harakat
Dominique
D
Pouny
Isabelle
I
Caron
Catherine
C
Moretti
Christian
C
Lavaud
Catherine
C
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D006172:Guyana; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D012503:Saponins; D014315:Triterpenes