title: Captive solvent [11C]acetate synthesis in GMP conditions.
abstract: Reliable procedure for the production of 1-[(11)C]acetate in GMP conditions was developed based on a combination of the captive-solvent Grignard reaction conducted in the sterile catheter followed by the convenient solid-phase extraction purification on a series of ion-exchange cartridges. The described procedure proved to be reliable in more than 30 patient productions. The process provides stable radiochemical yields (65% EOB) of sodium acetate (1-[(11)C]) of the Ph.Eur. quality (radiochemical purity better than 95%) in a short time (5 min).
authors.affiliation: Cyclotron unit of Geneva University Hospitals, Unité Cyclotron, Service de Médecine Nucléaire, Département de Radiologie et Informatique Médical, Hôpital Cantonal de Genève, CH-1211 Geneva-14, Switzerland. dmitri.soloviev@hcuge.ch
authors.forename: Dmitri
authors.initials: D
authors.lastname: Soloviev
authors.forename: Claire
authors.initials: C
authors.lastname: Tamburella
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000302:isolation & purification; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D011786:Quality Control; D012997:Solvents; D013678:Technology, Pharmaceutical / Q000592:standards
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D012997:Solvents