title: Heart rate turbulence and heart rate variability in patients with mitral valve prolapse.
abstract: OBJECTIVE
  Heart rate turbulence (HRT) and heart rate variability (HRV) have been shown to be independent and powerful predictors of mortality in a specific group of cardiac patients. However, the predictive values of HRV alone is modest and information on HRV in patients with mitral valve prolapse (MVP) has so far been conflicting. In addition, no studies have previously evaluated HRT in patients with MVP. To define better the effects of MVP on cardiac autonomic function, we assessed HRT and time-domain parameters of HRV in patients with MVP.
  
  
  RESULTS
  Fifty patients with MVP and 70 controls without MVP were investigated. The diagnosis of MVP was confirmed by cross-sectional echocardiography in the parasternal long-axis view and apical 4-chamber view. The HRV and turbulence analysis were assessed from a 24-hour Holter recording. When HRT parameters were compared, the values of the HRT onset and slope were significantly lower in MVP patients than in the controls group (-0.109+/-0.207 vs. -0.289+/-0.170%, P=0.001 and 8.6+/-7.2 vs. 11.5+/-7.4 ms/RRI, P=0.043, respectively) and the number of patients who had abnormal HRT onset was significantly higher in the MVP group than in controls (15 vs. 8, P=0.011). In addition, HRV parameters were not statistically different between the two groups.
  
  
  CONCLUSIONS
  Although we found that the decrease in HRV parameters was not significantly different between MVP patients and controls, HRT variables (especially HRT onset) were significantly lower in MVP patients. Therefore, in our opinion, HRT is an attractive, easily applicable, and better way of non-invasive risk prediction compared with another non-invasive risk predictor, HRV.
authors.affiliation: Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Izzet Baysal, 14280 Bolu, Turkey. drhuseyingunduz@yahoo.com
authors.forename: Huseyin
authors.initials: H
authors.lastname: Gunduz
authors.forename: Huseyin
authors.initials: H
authors.lastname: Arinc
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kayardi
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.forename: Serhan
authors.initials: S
authors.lastname: Ozyildirim
authors.forename: Cihangir
authors.initials: C
authors.lastname: Uyan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D018570:Risk Assessment