title: Seroreversion of HIV antibodies in patients with prolonged suppression of viraemia under HAART.
abstract: Prolonged virus suppression in chronically HIV-infected patients could hypothetically lead to antibody seroreversion. Eighty-four HIV-positive individuals with undetectable viraemia for longer than 5 years under HAART were examined. Only one individual, who had initiated HAART shortly after primary HIV infection, showed seroreversion. In contrast, the cure of hepatitis C virus (HCV) with interferon in 25 controls led to the loss of HCV antibodies in most cases. This information indirectly reflects that whereas HCV may be eradicable HIV is not.
authors.affiliation: Service of Microbiology, Hospital Carlos III, Madrid, Spain.
authors.forename: Aranzazu
authors.initials: A
authors.lastname: Amor
authors.forename: Carlos
authors.initials: C
authors.lastname: Toro
authors.forename: Victoria
authors.initials: V
authors.lastname: Jiménez
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Simón
authors.forename: Belén
authors.initials: B
authors.lastname: Ramos
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014766:Viremia / Q000188:drug therapy* / Q000276:immunology / Q000821:virology
chemical_list: D015483:HIV Antibodies