Endogenous stem and precursor cells for demyelinating diseases: an alternative for transplantation?
Remyelination can be very effective in human. However, this process ultimately fails in multiple sclerosis (MS). In this paper, we discuss the possibility of stimulating endogenous oligodendrocyte precursors to participate in remyelination in experimental models (rat and primate Callithrix jacchus) of MS through thyroid hormone (TH) administration. TH is in fact known to be a key signal in brain development, oligodendrocyte development and myelin protein gene expression regulation.
D'Intino
G
G
ASC-Lab, DIMORFIPA, University of Bologna, Italy.
Perretta
G
G
Taglioni
A
A
Calistri
M
M
Falzone
C
C
Baroni
M
M
Giardino
L
L
Calzà
L
L
D000818:Animals; D001921:Brain / Q000166:cytology*; D002454:Cell Differentiation; D003711:Demyelinating Diseases / Q000628:therapy*; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D013963:Thyroid Hormones / Q000494:pharmacology*
D013963:Thyroid Hormones