Cytokines and chemokines orchestrate atopic skin inflammation.
Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
Homey
Bernhard
B
Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany. Bernhard.Homey@uni-duesseldorf.de
Steinhoff
Martin
M
Ruzicka
Thomas
T
Leung
Donald Y M
DY
D002465:Cell Movement; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D012867:Skin / Q000276:immunology
D018925:Chemokines; D016207:Cytokines