title: Pleural liquid during hemorrhagic hypotension.
abstract: The effect of approximately 25% or 35% blood loss (b.l.) on volume, pressure, and protein concentration of pleural liquid has been determined in anesthetized rabbits in lateral or supine posture. Volume and pressure of pleural liquid did not change with 25% b.l. 30 and 60 min after beginning of hemorrhage, and with 35% b.l. at 30 min (bleeding time approximately 10 and 12 min, respectively). With 35% b.l. protein concentration of pleural liquid was 85% greater (P<0.01) than control; moreover, percent albumin was smaller (P<0.05), and percent globulin greater (P<0.05) than control. Decrease in arterial plasma protein concentration, hematocrit, and pH after hemorrhage fit literature data. Ventilation at 15 and 30 min increased (P<0.01) by 16% and 23%, respectively, with 25% b.l., but it did not change with 35% b.l., a condition borderline to survival in anesthetized rabbits without ad hoc treatment. Pleural liquid seems protected against derangements from hemorrhage up to 25% b.l. for periods shorter than 1 h.
authors.affiliation: Istituto di Fisiologia Umana I, Università di Milano, Via Mangiagalli 32, 20133 Milano, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Tresoldi
authors.forename: Cristina
authors.initials: C
authors.lastname: Porta
authors.forename: Luciano
authors.initials: L
authors.lastname: Zocchi
authors.forename: Emilio
authors.initials: E
authors.lastname: Agostoni
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006470:Hemorrhage / Q000150:complications* / Q000473:pathology*; D007022:Hypotension / Q000209:etiology* / Q000473:pathology*; D008297:Male; D010994:Pleura / Q000378:metabolism / Q000503:physiopathology*; D035422:Pleural Cavity / Q000378:metabolism* / Q000503:physiopathology; D011817:Rabbits; D012119:Respiration; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D013997:Time Factors
chemical_list: D012709:Serum Albumin; D012712:Serum Globulins