Skeletal myogenesis by human embryonic stem cells.
We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.
Zheng
Jun Ke
JK
Center for Developmental Biology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wang
Yi
Y
Karandikar
Aditi
A
Wang
Qian
Q
Gai
Hui
H
Liu
Ai Lian
AL
Peng
Chao
C
Sheng
Hui Zhen
HZ
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D054715:Cardiotoxins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology*; D019172:Transplantation Conditioning; D014183:Transplantation, Heterologous
D015415:Biomarkers; D054715:Cardiotoxins