title: Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection.
abstract: Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum.
authors.affiliation: Barts and the London School of Medicine, Institute of Cell and Molecular Science, Centre for Gastroenterology, Turner Street, London E1 2AD, United Kingdom.
authors.forename: I-Sarah
authors.initials: IS
authors.lastname: Lean
authors.forename: Sonia
authors.initials: S
authors.lastname: Lacroix-Lamandé
authors.forename: Fabrice
authors.initials: F
authors.lastname: Laurent
authors.forename: Vincent
authors.initials: V
authors.lastname: McDonald
mesh_terms: D000818:Animals; D002460:Cell Line; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum / Q000276:immunology*; D004195:Disease Models, Animal; D020895:Enterocytes / Q000276:immunology*; D007113:Immunity, Innate; D051379:Mice; D018345:Mice, Knockout; D014409:Tumor Necrosis Factor-alpha / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
chemical_list: D014409:Tumor Necrosis Factor-alpha