title: Antibacterial activity of YC-20, a new oxazolidinone.
abstract: OBJECTIVE
  YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined.
  
  
  RESULTS
  YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid.
  
  
  CONCLUSIONS
  This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences Shanghai 201203, China. cuiyingjie@yahoo.com
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Cui
authors.forename: Yaxian
authors.initials: Y
authors.lastname: Dang
authors.forename: Yushe
authors.initials: Y
authors.lastname: Yang
authors.forename: Shuhua
authors.initials: S
authors.lastname: Zhang
authors.forename: Ruyun
authors.initials: R
authors.lastname: Ji
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; C515253:YC-20 compound