title: Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
abstract: BACKGROUND
  Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP).
  
  
  METHODS
  Diagnostic assessment of 263 pediatric BP probands included lifetime history of psychotic symptoms as well as longitudinal follow-up; family history of psychiatric illness was determined for 1st degree relatives.
  
  
  RESULTS
  Pediatric BP probands with lifetime history of psychosis had a higher percentage of positive family history of anxiety disorders and suicide attempts as compared to probands with no history of psychosis.
  
  
  CONCLUSIONS
  Familial loading for a spectrum of internalizing disorders is associated with presentation of psychotic symptoms in pediatric BP.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. Richard_Rende@Brown.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Rende
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: David
authors.initials: D
authors.lastname: Axelson
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Gill
authors.forename: Sylvia
authors.initials: S
authors.lastname: Valeri
authors.forename: Laurel
authors.initials: L
authors.lastname: Chiappetta
authors.forename: Neal
authors.initials: N
authors.lastname: Ryan
authors.forename: Henrietta
authors.initials: H
authors.lastname: Leonard
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Hunt
authors.forename: Satish
authors.initials: S
authors.lastname: Iyengar
authors.forename: Martin
authors.initials: M
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002648:Child; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007389:Internal-External Control; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology