Adaptogenic activity of Caesalpinia bonduc seed extracts in rats.
Caesalpinia bonduc Roxb. (Caesalpiniaceae) seed extracts were screened for adaptogenic activity using cold stress model and swim endurance model, the seed coat as well as kernel extracts showed significant antistress activity when administered orally at a dose of 300 mg/kg. The extracts significantly increased the swim endurance time. Stress induced animals exhibited hypoglycaemia as well as depletion in serum cortisol level and increased total leukocyte count, the extracts showed a significant action in overcoming these imbalances. It was also found that extracts proved efficient in controlling the hyperlipidaemic condition due to stress.
Kannur
D M
DM
Department of Pharmacognosy & Phytochemistry, MAEER's Maharashtra Institute of Pharmacy, Kothrud, Pune 411038, India. dmkannur@rediffmail.com
Hukkeri
V I
VI
Akki
K S
KS
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D029911:Caesalpinia / Q000737:chemistry*; D003080:Cold Temperature; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D013312:Stress, Physiological / Q000503:physiopathology / Q000517:prevention & control; D013550:Swimming / Q000502:physiology
D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D006854:Hydrocortisone