title: Activity of trabectedin (ET-743, Yondelis) in metastatic uterine leiomyosarcoma.
abstract: BACKGROUND
  The ongoing search for more effective agents in the treatment of uterine leiomyosarcomas is warranted because of the poor prognosis related to these tumors.
  
  
  METHODS
  A case of advanced, recurrent and refractory uterine leiomyosarcoma is presented that responded to trabectedin (ET-743) 1.2 mg/m2 intravenously over 24 h every 3 weeks after failing four prior regimens. A durable objective response lasting at least 8 months was documented.
  
  
  CONCLUSIONS
  Trabectedin (ET-743) has activity in uterine leiomyosarcoma and warrants further investigation.
authors.affiliation: Division of Gynecologic Oncology, Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA 92868, USA.
authors.forename: Devansu
authors.initials: D
authors.lastname: Tewari
authors.forename: Bahman
authors.initials: B
authors.lastname: Saffari
authors.forename: Carol
authors.initials: C
authors.lastname: Cowan
authors.forename: Anita C
authors.initials: AC
authors.lastname: Wallick
authors.forename: M Zach
authors.initials: MZ
authors.lastname: Koontz
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Monk
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D004149:Dioxoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D015507:Drugs, Investigational / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D009364:Neoplasm Recurrence, Local; D044005:Tetrahydroisoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000077606:Trabectedin; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D015507:Drugs, Investigational; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin