title: Structural anatomy of pure and hemianopic alexia.
abstract: BACKGROUND
  The two most common types of acquired reading disorder resulting from damage to the territory of the dominant posterior cerebral artery are hemianopic and pure alexia. Patients with pronounced hemianopic alexia have a right homonymous hemianopia that encroaches into central or parafoveal vision; they read individual words well, but generate inefficient reading saccades when reading along a line of text. Patients with pure alexia also often have a hemianopia but are more disabled, making frequent errors on individual words; they have sustained damage to a brain region that supports efficient word identification.
  
  
  OBJECTIVE
  To investigate the differences in lesion site between hemianopic alexia and pure alexia groups, as rehabilitative techniques differ between the two conditions.
  
  
  METHODS
  High-resolution magnetic resonance images were obtained from seven patients with hemianopic alexia and from six patients with pure alexia caused by a left occipital stroke. The boundary of each lesion was defined and lesion volumes were then transformed into a standard stereotactic space so that regional comparisons could be made.
  
  
  RESULTS
  The two patient groups did not differ in terms of damage to the medial left occipital lobe, but those with pure alexia had additional lateral damage to the posterior fusiform gyrus and adjacent tissue.
  
  
  CONCLUSIONS
  Clinicians will be able to predict the type of reading disorder patients with left occipital lesions have from simple tests of reading speed and the distribution of damage to the left occipital lobe on brain imaging. This information will aid management decisions, including recommendations for reading rehabilitation.
authors.affiliation: MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. a.leff@fil.ion.ucl.ac.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Leff
authors.forename: G
authors.initials: G
authors.lastname: Spitsyna
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
authors.forename: R J S
authors.initials: RJ
authors.lastname: Wise
mesh_terms: D000368:Aged; D020237:Alexia, Pure / Q000209:etiology / Q000503:physiopathology* / Q000534:rehabilitation*; D002536:Cerebral Arteries / Q000473:pathology; D005260:Female; D006423:Hemianopsia / Q000209:etiology / Q000503:physiopathology* / Q000534:rehabilitation*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D015835:Ocular Motility Disorders; D020521:Stroke / Q000150:complications