Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice.
Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.
Ruggiero
P
P
Chiron s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy. paolo_ruggiero@chiron.com
Tombola
F
F
Rossi
G
G
Pancotto
L
L
Lauretti
L
L
Del Giudice
G
G
Zoratti
M
M
D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D059808:Polyphenols; D013047:Specific Pathogen-Free Organisms; D013634:Tannins / Q000008:administration & dosage / Q000627:therapeutic use
D001426:Bacterial Proteins; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013634:Tannins; C074689:VacA protein, Helicobacter pylori