Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study.
The study was conducted to investigate the effect of conservative surgery of ovarian endometriomas before an ICSI cycle. Ninety-nine patients with endometriomas who were referred to an intracytoplasmic sperm injection (ICSI) cycle were enrolled in the study. The patients were prospectively randomized into two groups; group I (49 patients) underwent conservative ovarian surgery before the ICSI cycle and group II (50 patients) underwent the ICSI cycle directly. The stimulation was started 3 months after the operation in group I and directly in group II. In the ovarian surgery group, stimulation was significantly longer (14.0 days in group I and 10.8 days in group II; P = 0.001), total recombinant FSH dose was significantly higher (4575 IU in group I and 3675 IU in group II; P = 0.001), and mean number of mature oocytes was significantly lower (7.8 in group I and 8.6 in group II; P = 0.032). There was no difference in terms of fertilization (86% in group I and 88% in group II), implantation (16.5% in group I and 18.5% in group II) and pregnancy rates (34% in group I and 38% in group II). Ovarian surgery resulted in longer stimulation, higher FSH requirement and lower oocyte number, but fertilization, pregnancy and implantation rates did not differ between the groups.
Demirol
Aygül
A
Clinic Women Health, Infertility and IVF Centre, Cankaya Caddesi, no. 20/3, Ankara, Turkey. ademirol@gmail.com
Guven
Suleyman
S
Baykal
Cem
C
Gurgan
Timur
T
D000328:Adult; D010064:Embryo Implantation; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010049:Ovarian Diseases / Q000601:surgery*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods