The phytoalexins from cauliflower, caulilexins A, B and C: isolation, structure determination, syntheses and antifungal activity.
Our continuous search for phytoalexins from crucifers led us to examine phytoalexin production in florets of cauliflower (Brassica oleracea var. botrytis) under abiotic (UV light) elicitation. Four known (isalexin, S-(-)-spirobrassinin, 1-methoxybrassitin, brassicanal C) and three new (caulilexins A-C) phytoalexins were isolated. The syntheses and antifungal activity of caulilexins A-C against the economically important pathogenic fungi Leptosphaeria maculans, Rhizoctonia solani and Sclerotinia sclerotiorum, and the first synthesis of brassicanal C are reported.
Pedras
M Soledade C
MS
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. soledade.pedras@usask.ca
Sarwar
Mohammed G
MG
Suchy
Mojmir
M
Adio
Adewale M
AM
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D001937:Brassica / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007919:Leptospira / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects; D012717:Sesquiterpenes; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000094162:Phytoalexins
D000935:Antifungal Agents; D007211:Indoles; D012717:Sesquiterpenes; D013729:Terpenes; C514565:caulilexin A; C514566:caulilexin B; C514567:caulilexin C; D000094162:Phytoalexins