title: Quantification of breath carbon disulphide and acetone following a single dose of disulfiram (Antabuse) using selected ion flow tube mass spectrometry (SIFT-MS).
abstract: Selected ion flow tube mass spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse). Carbon disulphide is a product of the metabolism of disulfiram and is excreted mainly through the lungs. Acetone is a product of normal metabolism and appears in the breath of all individuals. These breath analyses were performed in single exhalations and the results were available in real time. The levels of breath acetone and carbon disulphide were compared with levels obtained from a control subject who had not ingested disulfiram. Breath carbon disulphide was seen to increase from 15 p.p.b. to 618 p.p.b. over a 28-hour period, in the single individual tested, following ingestion of disulfiram, while acetone levels increased from 300 p.p.b. (normal) to over 4000 p.p.b. (greatly elevated). No such increases were seen in the breath of the control subject over the same period. An obvious positive correlation between breath carbon disulphide and acetone concentrations following disulfiram ingestion is seen and discussed.
authors.affiliation: Academic Psychiatry Unit, Keele University Medical School, Academic Suite, Harplands Hospital, UK.
authors.forename: Roger N
authors.initials: RN
authors.lastname: Bloor
authors.forename: Patrick
authors.initials: P
authors.lastname: Spanĕl
authors.forename: David
authors.initials: D
authors.lastname: Smith
mesh_terms: D000096:Acetone / Q000032:analysis* / Q000378:metabolism*; D000328:Adult; D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000494:pharmacology*; D001944:Breath Tests; D002246:Carbon Disulfide / Q000032:analysis* / Q000378:metabolism*; D004221:Disulfiram / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000295:instrumentation*; D013997:Time Factors
chemical_list: D000427:Alcohol Deterrents; D000096:Acetone; D002246:Carbon Disulfide; D004221:Disulfiram