title: Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network.
abstract: Human kallikrein 11 (hK11) was evaluated in a percentage free PSA-based artificial neural network (ANN) to reduce unnecessary prostate biopsies. Serum samples from 357 patients with (n=132) and without (n=225) prostate cancer (PCa) were analyzed and ANN models were constructed and compared to all parameters. The discriminatory power of hK11 was lower than that of PSA, but receiver operator characteristic (ROC) analyses demonstrated significantly larger areas under the curves for the ANN compared to all other parameters. ANNs with hK11 may lead to a further reduction in unnecessary prostate biopsies, especially when analyzing patients with less than 15% free PSA.
authors.affiliation: Department of Urology, University Hospital Charité, D-10098 Berlin, Germany. carsten.stephan@charite.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Stephan
authors.forename: Hellmuth-Alexander
authors.initials: HA
authors.lastname: Meyer
authors.forename: Henning
authors.initials: H
authors.lastname: Cammann
authors.forename: Terukazu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Diamandis
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008297:Male; D016571:Neural Networks, Computer; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C114880:trypsin-like serine protease; D012697:Serine Endopeptidases; D017430:Prostate-Specific Antigen