Constituents of Chrysothamnus viscidiflorus.
A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells.
Ahmed
Ahmed A
AA
Department of Chemistry, Faculty of Science, El-Minia University, El-Minia 61519, Egypt. abdellaahmed@yahoo.com
Hegazy
Mohamed-Elamir F
ME
Hassan
Nahed M
NM
Wojcinska
Malgorzata
M
Karchesy
Joe
J
Pare
Paul W
PW
Mabry
Tom J
TJ
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure
D000970:Antineoplastic Agents