Persistent Staphylococcus capitis septicemia in a preterm infant.
A preterm infant had persistent Staphylococcus capitis septicemia with 11 consecutive positive blood cultures over a period of 33 days. The clinical evidence suggested that the source of infection probably originated from the gastrointestinal tract. The combination of rifampin and linezolid treatment, together with prolonged stoppage of enteral feeding, successfully terminated the infection. Rifampin and linezolid should be considered as alternative antimicrobial agents when glycopeptides fail to eradicate Gram-positive pathogens from the host.
Ng
Pak C
PC
Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. pakcheungng@cuhk.edu.hk
Chow
Viola C Y
VC
Lee
Cheuk H
CH
Ling
Julia M L
JM
Wong
Hiu L
HL
Chan
Raphael C Y
RC
D000081:Acetamides / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000302:isolation & purification*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid; D012293:Rifampin