Neurogenesis in the adult central nervous system.
Contrary to the long-held dogma, neurogenesis occurs throughout adulthood, and neural stem cells reside in the adult central nervous system (CNS) in mammals. The developmental process of the brain may thus never end, and the brain may be amenable to repair. Neurogenesis is modulated in a wide variety of physiological and pathological conditions, and is involved in processes such as learning and memory and depression. However, the relative contribution of newly generated neuronal cells to these processes, as well as to CNS plasticity, remains to be determined. Thus, not only neurogenesis contributes to reshaping the adult brain, it will ultimately lead us to redefine our knowledge and understanding of the nervous system.
Taupin
Philippe
P
National Neuroscience Institute, Singapore, 11 Jalan Tan Tock Seng, Singapore 308433. obgpjt@nus.edu.sg
D000818:Animals; D001921:Brain / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000503:physiopathology; D006801:Humans; D008322:Mammals; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid