title: Search for genetic factors associated with susceptibility to multiple sclerosis.
abstract: Multiple sclerosis (MS) is a cell-mediated autoimmune disease characterized by type-1 cytokine production. Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-alpha genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single-nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL-21 and IL-23.
authors.affiliation: Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università degli studi di Palermo, Italy.
authors.forename: Giusi Irma
authors.initials: GI
authors.lastname: Forte
authors.forename: Paolo
authors.initials: P
authors.lastname: Ragonese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salemi
authors.forename: Letizia
authors.initials: L
authors.lastname: Scola
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Marco
authors.initials: M
authors.lastname: D'Amelio
authors.forename: Antonio
authors.initials: A
authors.lastname: Crivello
authors.forename: Norma
authors.initials: N
authors.lastname: Di Benedetto
authors.forename: Domenico
authors.initials: D
authors.lastname: Nuzzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Giacalone
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
mesh_terms: D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D018664:Interleukin-12 / Q000235:genetics; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12