title: Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia.
abstract: Familial combined hyperlipidemia (FCHL), with a marked elevation of apolipoprotein B (apoB), is estimated to cause 10-20% of premature coronary artery disease. However, little data are available to demonstrate the associations of apoB with pulse pressure and glucose levels in FCHL families in China. This study was to investigate the potential influence factors for blood pressure and glucose phenotypes in FCHL families by multiple linear regression analysis. We recruited 147 FCHL relatives and 90 spouses, aged 30 to 60 years, from 42 Chinese families with FCHL. Our results showed that triglyceride and low density lipoprotein cholesterol were associated with fasting glucose levels (all P<0.05). Body mass index and glucose significantly correlated to systolic blood pressure, diastolic blood pressure, and mean arterial pressure, respectively (all P<0.05). Furthermore, apoB was significantly related to pulse pressure and glucose in FCHL families (all P<0.05). Thus, this study demonstrates that apoB is significantly associated with pulse pressure and glucose levels in FCHL families. Accordingly, our data suggest that apoB may be a candidate risk marker for pulse pressure and glucose in FCHL populations.
authors.affiliation: Center for Heart Failure, Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences, Beilishi Road 167, Beijing, 100037, China. pei_weidong@yahoo.com.cn
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Pei
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Sun
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Wei-yue
authors.initials: WY
authors.lastname: Zheng
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Chao-yang
authors.initials: CY
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Gong
authors.forename: Paul N
authors.initials: PN
authors.lastname: Hopkins
authors.forename: Ru-tai
authors.initials: RT
authors.lastname: Hui
authors.forename: Li-sheng
authors.initials: LS
authors.lastname: Liu
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D017677:Age Distribution; D001055:Apolipoproteins B / Q000097:blood* / Q000378:metabolism; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure / Q000502:physiology*; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003625:Data Collection; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000175:diagnosis* / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010375:Pedigree; D011336:Probability; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL