[Serrated neoplasia of the gastro-intestinal tract].
Serrated neoplasia of the gastro-intestinal tract have peculiar microscopic and molecular features that are still incompletely described. Some serrated polyps seem to be involved in a new carcinogenic pathway in the colon: the serrated neoplasia pathway, with hypermethylation of the cytosine-guanine dinucleotides, located in the promoter of some genes such as h-MLH1, BRAF and MGMT. The natural history of the serrated polyps and their risk for progression to malignancy are still unclear. There is no official guideline for the management of serrated polyps. The aim of this article is to describe the epidemiological, morphological, immunohistochemical and molecular characteristics of the serrated neoplasia of the gastrointestinal tract: hyperplastic polyps, "traditional" serrated adenomas, mixed hyperplastic and adenomatous polyps, sessile serrated adenomas, hyperplastic polyposis and serrated adenocarcinomas.
Chatelain
Denis
D
Service d'Anatomie Pathologique, CHU Amiens, Place Victor Pauchet, 80000 Amiens Cedex 01.
Terris
Benoît
B
Fléjou
Jean-François
JF
D000230:Adenocarcinoma / Q000473:pathology; D000236:Adenoma / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007417:Intestinal Polyps / Q000473:pathology