Preliminary findings for preemptive analgesia with inhaled morphine: efficacy in septoplasty and septorhinoplasty cases.
OBJECTIVE
The aim of this study was to assess the efficacy of inhaled morphine for preemptive analgesia in patients who undergo septoplasty or septorhinoplasty. STUDY PLAN AND METHODS: Eighty ASA I-II patients scheduled for septoplasty or septorhinoplasty were recruited and randomly divided into 2 groups that received different treatments 10 minutes prior to induction. The preemptive analgesia group (Group P, n = 40) received 65 mug kg(-1) morphine sulphate (a 3-mL volume) via an oral nebulizer, and the control group (Group C, n = 40) received 3 mL 0.9% sodium chloride (physiological saline) via the same type of nebulizer. Blood pressure, oxygen saturation, heart rate, time to first requirement for analgesia, and occurrence of nausea/vomiting were recorded.


RESULTS
There were no significant differences between Groups P and C with respect to age, body weight, sex distribution, or duration of surgery. There was also no significant difference between the group frequencies of postoperative nausea/vomiting. The time to first requirement for analgesia was significantly longer in Group P than Group C.


CONCLUSIONS
The results of this preliminary study suggest that a single dose of inhaled morphine administered preemptively prior to septoplasty or septorhinoplasty provides effective postoperative analgesia.


METHODS
B-3b.
Onal
Selami Ateş
SA
Department of Algology, Firat University, 23119 Elaziğ, Turkey.
Keleş
Erol
E
Toprak
Gonca Cağlar
GC
Demirel
Ismail
I
Alpay
H Cengiz
HC
Avci
Levent
L
D000280:Administration, Inhalation; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000769:Anesthesia, Inhalation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009300:Nasal Septum / Q000601:surgery*; D009667:Nose Deformities, Acquired / Q000601:surgery*; D011446:Prospective Studies; D012225:Rhinoplasty / Q000379:methods*; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D009020:Morphine