Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells.
Naringenin is a naturally occurring citrus flavanone. In this study, we examined the effect of naringenin on melanogenesis in mouse B16 melanoma cells. Melanin contents and tyrosinase activities were strongly increased by naringenin. Naringenin was found to cause marked increases in the expression levels of melanogenic enzymes.
Ohguchi
Kenji
K
Gifu International Institute of Biotechnology. kohguchi@giib.or.jp
Akao
Yukihiro
Y
Nozawa
Yoshinori
Y
D000818:Animals; D045744:Cell Line, Tumor; D002957:Citrus / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D015394:Molecular Structure
D044950:Flavanones; D008543:Melanins; C005273:naringenin