title: A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors.
abstract: OBJECTIVE
  Rectal carcinoid tumors smaller than 10 mm can be resected with local excision using endoscopy. In order to remove rectal carcinoid tumors completely, we evaluated endoscopic mucosal resection with a ligation device in this pilot control randomized study.
  
  
  METHODS
  Fifteen patients were diagnosed with rectal carcinoid tumor (less than 10 mm) in our hospital from 1993 to 2002. There were 9 males and 6 females, with a mean age 61.5 years (range, 34-77 years). The patients had no complaints of carcinoid syndrome symptoms. Fifteen patients were randomly divided into 2 groups: 7 carcinoid tumors were treated by conventional endoscopic resection, and 8 carcinoid tumors were treated by endoscopic resection using a ligation device.
  
  
  RESULTS
  All rectal carcinoid tumors were located at the middle to distal rectum. The size of the tumors varied from 3 mm to 10 mm and background characteristics of the patients were not different in the two groups. The rate of complete removal of carcinoid tumors using a ligation device (100%, 8/8) was significantly higher than that of conventional endoscopic resection (57.1%, 4/7). The three patients had tumor involvement of deep margin, for which additional treatment was performed. No complications occurred during or after endoscopic resection using a ligation device. All patients in the both groups were alive during the 3-year observation period.
  
  
  CONCLUSIONS
  Endoscopic resection using a ligation device is a useful and safe method for resection of small rectal carcinoid tumors.
authors.affiliation: Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Saga 849-8501, Japan. sakatah2@post.saga-med.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakata
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Iwakiri
authors.forename: Akifumi
authors.initials: A
authors.lastname: Ootani
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsunada
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ogata
authors.forename: Hibiki
authors.initials: H
authors.lastname: Ootani
authors.forename: Ryo
authors.initials: R
authors.lastname: Shimoda
authors.forename: Kanako
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Sakata
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Amemori
authors.forename: Kotaro
authors.initials: K
authors.lastname: Mannen
authors.forename: Masanobu
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: Kazuma
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000601:surgery*; D005260:Female; D006801:Humans; D008026:Ligation / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011351:Proctoscopy / Q000379:methods*; D012004:Rectal Neoplasms / Q000601:surgery*; D012007:Rectum / Q000601:surgery; D016896:Treatment Outcome