[The formation and role of beta-amyloid peptides in neurons upon amyloidosis].
The formation mechanism of amyloid peptides in normally functioning neuron and upon the development of amyloidosis resulting in neuron death is described. Amyloid peptides are formed by enzymatic processing of a large protein precursor and participate in intermolecular interactions after conformational rearrangements resulting in the formation of pathogenic structures. They enter into the cascade of molecular and cellular events leading to amyloidosis and death of nervous cells. These molecular events clarify the relation between the conformation and function of neuropathogenic peptides and the role of this relation in the development of pathology of differentiated neurons. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2006, vol. 32, no. 3; see also http://www.maik.ru.
Baĭramov
V M
VM
Mal'tsev
A V
AV
Kaminskiĭ
Iu G
IuG
Fediukin
V S
VS
Brindar
N G
NG
D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000686:Amyloidosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D016923:Cell Death; D002454:Cell Differentiation; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D010455:Peptides / Q000235:genetics / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D010455:Peptides