Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital.
OBJECTIVE
We have been engaged in basic and clinical research on photodynamic therapy (PDT) and photodynamic diagnosis (PDD) for more than 25 years.


METHODS
PDT for 264 centrally located early-stage lung cancer lesions yielded an initial complete response (CR) rate of 84.8%. PDT is now becoming a standard option for centrally located stage 0 (TisN0M0) and stage I (T1N0M0) lung cancer. It is an attractive option for elderly patients in poor physical condition.


RESULTS
Recent results of interstitial PDT for peripheral-type lung cancers suggest that it may be a promising local curative treatment modality for lesions less than 1.0 cm in diameter.


CONCLUSIONS
In this article, we introduce our recent clinical trials of PDT for lung cancers (both central and peripheral), and new techniques of PDD in sentinel node navigation biopsy for breast cancers. Moreover, we introduce basic research on cancers and infectious diseases in order to expand the clinical applications of PDT.
Kato
H
H
Department of Thoracic Surgery, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
Usuda
J
J
Okunaka
T
T
Furukawa
K
K
Honda
H
H
Sakaniwa
N
N
Suga
Y
Y
Hirata
T
T
Ohtani
K
K
Inoue
T
T
Maehara
S
S
Kubota
M
M
Yamada
K
K
Tsuitsui
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy*; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D016106:Methicillin Resistance; D051379:Mice; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018579:Patient Selection; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus
C115550:ATX-S10; D017319:Photosensitizing Agents; D011166:Porphyrins; D017323:Dihematoporphyrin Ether; C053434:Talaporfin