title: Optical and electrochemical detection techniques for cell-based microfluidic systems.
abstract: The ability to fabricate microfluidic systems with complex structures and with compatible dimensions between the microfluidics and biological cells have attracted significant attention in the development of microchips for analyzing the biophysical and biochemical functions of cells. Just as cell-based microfluidics have become a versatile tool for biosensing, diagnostics, drug screening and biological research, detector modules for cell-based microfluidics have also undergone major development over the past decade. This review focuses on detection methods commonly used in cell-based microfluidic systems, and provides a general survey and an in-depth look at recent developments in optical and electrochemical detection methods for microfluidic applications for biological systems, particularly cell analysis. Selected examples are used to illustrate applications of these detection systems and their advantages and weaknesses.
authors.affiliation: Biochip Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yi
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Cheuk-Wing
authors.initials: CW
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jianlong
authors.initials: J
authors.lastname: Zhao
authors.forename: Mengsu
authors.initials: M
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques; D018929:Cell Culture Techniques / Q000295:instrumentation*; D004563:Electrochemistry; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics; D010777:Photochemistry