title: Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction.
abstract: Recent prospective findings have shown that cannabis use by young people could be a risk factor for psychotic symptoms in adulthood, but the long-term impact of cannabis abuse on the clinical features of declared schizophrenia remains to be explored. We assessed the independent influence of cannabis abuse on the clinical symptoms of schizophrenia, after controlling for frequently co-occurring addictive disorders. Patients with schizophrenia, and with (N=66), or without (N=139) cannabis abuse, were compared for lifetime positive and negative symptoms, taking into account presence of any other addictive disorders. The incidence of the abuse of drugs other than cannabis was nearly five times greater amongst patients with both schizophrenia and cannabis abuse. When the analyses were limited to subjects with no other abuse, less avolution and fewer apathy symptoms were still detected in patients with schizophrenia and cannabis abuse than in those with no abuse (p=0.0001). In contrast, between-group differences for positive symptoms were abolished when multiple substance abuses were taken into account. The strong association between cannabis abuse and fewer negative symptoms in schizophrenia was thus replicated in this sample, but once co-morbid addictive disorders had been controlled no influence of cannabis abuse on hallucinations was detected. Distinguishing the effects of co-occurring addictive disorder(s) in patients with schizophrenia and cannabis dependence may thus be important when attempting to analyse the impact of cannabis abuse.
authors.affiliation: INSERM U675, Institut Fédératif de Recherche (IFR 02), Faculty of Xavier Bichat 16 rue Henri Huchard, 75018 Paris, France. caroline.dubertret@lmr.aphp.fr
authors.forename: Caroline
authors.initials: C
authors.lastname: Dubertret
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bidard
authors.forename: Jean
authors.initials: J
authors.lastname: Adès
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D003702:Delusions / Q000209:etiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications* / Q000453:epidemiology*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications* / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index