Best evidence topic report. The use of loop diuretics in acute renal failure in critically ill patients to reduce mortality, maintain renal function, or avoid the requirements for renal support.
A short cut review was carried out to establish whether loop diuretics are useful for critically ill patients with renal failure. A total of 1017 citations were reviewed of which two answered the three part question. The clinical bottom line is that in critically ill patients with acute renal failure, there is no evidence to suggest that the use of loop diuretics reduces mortality, reduces length of ITU/hospital stay, or increases the recovery of renal function.
Davis
Anthony
A
North West School of Anaesthesia, Manchester, UK.
Gooch
Ingrid
I
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000401:mortality; D000368:Aged; D015331:Cohort Studies; D016638:Critical Illness; D004232:Diuretics / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D017582:Renal Replacement Therapy; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D004232:Diuretics; D049994:Sodium Potassium Chloride Symporter Inhibitors