Designer macrophages: oxidative metabolism fuels inflammation repair.
Macrophages play a central role in immunity, contributing to both the initiation and resolution of inflammation. In this issue of Cell Metabolism, Vats et al. provide insight into the mechanisms by which reparative macrophages are generated and reveal a previously unappreciated link between this anti-inflammatory axis and mitochondrial oxidative metabolism (Vats el al., 2006).
Lacy-Hulbert
Adam
A
Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Moore
Kathryn J
KJ
D000818:Animals; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D015847:Interleukin-4 / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological
D005227:Fatty Acids; D015847:Interleukin-4