title: [Medium and long-term results of anatomical correction of transposition of the great arteries in Marseille].
abstract: The object of this study was to evaluate the results of anatomical correction of transposition of the great arteries (TGA) in an inter-regional centre. The characteristics of 220 patients operated between 1985 and 2002 were analysed. Prenatal diagnosis of TGA was made in 38 patients (17%) including 36 of the 109 patients operated since 1995 (33%) and leading to earlier atrial septostomy in this situation (p= 0.046). Since 1995, the global early mortality of 12.3% has been significantly reduced to 5.5% (N= 6) including 4.4% (3/68 cases) of simple TGA (p= 0.002). In multivariate analysis, the only independent risk factor for early mortality was the occurrence of a major per-operative complication (p< 0.0001). The average follow-up was 4.8 +/- 4.5 years with an 86% survival at 5, 10 and 15 years and 97% survival at 5 years for patients operated after 1995. There were 22 reoperations including 14 on the right ventricular outflow tract. The non-reoperation rate at 10 years was 80% for simple TGA versus 70% in complex TGA (p= 0.0001). Survivors are asymptomatic with a normal ECG and normal LV function on echocardiography. Five patients have significant pulmonary stenosis and 4 have mild aortic regurgitation. The exercise stress tests performed between the ages of 7 and 10 were all normal. The authors conclude that that modern and reproducible management of TGA is possible in an inter-regional centre with results comparable to those of surgical centres of reference.
authors.affiliation: Service de chirurgie thoracique et cardiovasculaire, Hôpital d'Enfants de la Timone, Marseille. olivier.ghez@ap-hm.fr
authors.forename: O
authors.initials: O
authors.lastname: Ghez
authors.forename: A
authors.initials: A
authors.lastname: Fraisse
authors.forename: D
authors.initials: D
authors.lastname: Blayac
authors.forename: F
authors.initials: F
authors.lastname: Ughetto
authors.forename: F
authors.initials: F
authors.lastname: Aubert
authors.forename: D
authors.initials: D
authors.lastname: Kalfa
authors.forename: M
authors.initials: M
authors.lastname: Voisin
authors.forename: B
authors.initials: B
authors.lastname: Kreitmann
authors.forename: D
authors.initials: D
authors.lastname: Metras
mesh_terms: D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D005260:Female; D005602:France; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014188:Transposition of Great Vessels / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome