title: Amniotic trisomy 11 mosaicism--is it a benign finding?
abstract: OBJECTIVE
  A case of prenatally diagnosed trisomy 11 mosaicism with a normal outcome is reported and the medical literature on prenatal detection of this finding is reviewed.
  
  
  METHODS
  Proportion of cells with trisomy 11 was evaluated in amniocytes, fetal blood lymphocytes, newborn fibroblasts and urinary epithelial cells. Karyotype studies and fluorescence in situ hybridization analysis using the 11q13LS1 CCND1 probe were performed.
  
  
  RESULTS
  Trisomy 11 level III mosaicism of 26% was detected in amniotic fluid cells. Periumbilical blood sampling showed a normal fetal karyotype. No fetal structural abnormalities were noted on ultrasound scan. The infant was spontaneously delivered and had normal physical findings at birth. No evidence of trisomic cells was found on extensive postnatal evaluation, implying an extraembryonic origin. Molecular analysis excluded uniparental disomy of chromosome 11. At 1 year of age, the baby is developing normally.
  
  
  CONCLUSIONS
  Only three reports on trisomy 11 mosaicism identified at amniocentesis have been published previously, all with a normal outcome. Additional cases of prenatally diagnosed mosaicism for trisomy 11 are necessary to assess more accurately the clinical significance of this finding.
authors.affiliation: Department of Medical Genetics, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. basel@post.tau.ac.il
authors.forename: Lina
authors.initials: L
authors.lastname: Basel-Vanagaite
authors.forename: Bella
authors.initials: B
authors.lastname: Davidov
authors.forename: Jane
authors.initials: J
authors.lastname: Friedman
authors.forename: Yosefa
authors.initials: Y
authors.lastname: Yeshaya
authors.forename: Nurit
authors.initials: N
authors.lastname: Magal
authors.forename: Valerie
authors.initials: V
authors.lastname: Drasinover
authors.forename: Mordechai
authors.initials: M
authors.lastname: Shohat
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D011379:Prognosis; D014314:Trisomy / Q000175:diagnosis*