Delayed corneal epithelial wound healing after penetrating keratoplasty in individuals with lattice corneal dystrophy.
OBJECTIVE
To investigate whether corneal epithelial cells of individuals with lattice corneal dystrophy (LCD) possess an intrinsic defect.


METHODS
Retrospective case-control study.


METHODS
The medical charts of nine individuals with LCD and those of 14 patients with keratoconus and 11 patients with corneal leukoma (controls), all of whom underwent penetrating keratoplasty (PKP) in one eye at Yamaguchi University Hospital between February 1998 and November 2001, were examined for the time for epithelial resurfacing after surgery.


RESULTS
The time required for resurfacing of the corneal epithelium after PKP was significantly greater in LCD patients (8.56 +/- 4.95 days, mean +/- SD) than in patients with either keratoconus (1.71 +/- 0.91 days, P = .006) or corneal leukoma (3.00 +/- 1.95 days, P = .03).


CONCLUSIONS
Corneal epithelial wound healing was delayed in LCD patients after PKP, suggesting that the keratoepithelin gene mutations responsible for this condition affect corneal epithelial cells.
Kawamoto
Koji
K
Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan. k.kawamo@yamaguchi-u.ac.jp
Morishige
Naoyuki
N
Yamada
Naoyuki
N
Chikama
Tai-Ichiro
T
Nishida
Teruo
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003317:Corneal Dystrophies, Hereditary / Q000503:physiopathology* / Q000601:surgery*; D019573:Epithelium, Corneal / Q000503:physiopathology*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology / Q000601:surgery; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012189:Retrospective Studies; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000235:genetics; D014945:Wound Healing / Q000502:physiology*; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein