[Analysis of human H5N1 virus hemagglutinin gene isolated from the mainland of China].
BACKGROUND
To analyze the genetic and antigenic characteristics of human H5N1 virus isolated from the mainland of China.


METHODS
The hemagglutinin (HA) gene of human H5N1 virus were sequenced and analyzed.


RESULTS
The results of HA gene sequencing showed that all the virus isolates belong to the same group because of the high similarity, but they were different from the virus isolated from Thailand and Vietnam. The sequence data also showed that the receptor specificity and the connecting peptide between HA1 and HA2 are still avian influenza origin.


CONCLUSIONS
The virus isolates from mainland of China until now belong to the same group and are different from the virus isolated from Thailand and Vietnam, and there is no evidence showing the human-avian influenza reassortant and recombination.
Shu
Yue-long
YL
Chinese Influenza Center, Institute for Viral Disease Control and Prevention, State Key Laboratory for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. yshu@vip.sina.com
Lan
Yu
Y
Wen
Le-ying
LY
Zhao
Xin-sheng
XS
Zhang
Ye
Y
Dong
Jie
J
Duan
Shu-min
SM
Nie
Kai
K
Zhang
Xiao-guang
XG
Wang
Da-yan
DY
Yao
Li-hong
LH
Guo
Yuan-ji
YJ
D000818:Animals; D002642:Chick Embryo; D002681:China; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D019267:Hemagglutinin Glycoproteins, Influenza Virus