Clinical efficacy of intravenous colistin therapy in combination with ceftazidime in severe MDR P. aeruginosa systemic infections in two haematological patients.
Nosocomial infections due to MDR P. aeruginosa are an increasing problem. Therapeutical options are few. We describe two haematological patients with severe neutropenia and systemic infection due to MDR P. aeruginosa treated successfully with colistin plus ceftazidime. Severe adverse events were not described.
Tascini
C
C
Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Menichetti
F
F
Stefanelli
A
A
Loni
C
C
Lambelet
P
P
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000209:etiology; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use*; D003092:Colitis / Q000209:etiology / Q000601:surgery; D004198:Disease Susceptibility; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000150:complications; D010538:Peritonitis / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology / Q000382:microbiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology / Q000601:surgery; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D053706:Typhlitis / Q000150:complications
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D003091:Colistin