title: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly pathogenic genes.
abstract: We full genome characterised the newly discovered avian influenza virus H5N7 subtype combination isolated from a stock of Danish game ducks to investigate the composition of the genome and possible features of high pathogenicity. It was found that the haemagglutinin and the acidic polymerase genes were closely related to a low pathogenic H5 strain (A/Duck/Denmark/65047/04 H5N2). The neuraminidase and the non-structural genes were closely related to the highly pathogenic H7N7 strains from The Netherlands 2003. The basic polymerase genes 1 and 2 were shared between the Danish H5N7 and H5N2 and the H7N7 from The Netherlands. The nucleoprotein and the matrix genes were closely related to H6 strains. Thus, the new H5N7 subtype share genes with H5, H7 and H6 subtypes and possesses internal genes originating from highly pathogenic strains. The findings emphasize the need for surveillance presumed low pathogenic avian influenza A viruses.
authors.affiliation: Department of Virology, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. kbr@ssi.dk
authors.forename: K
authors.initials: K
authors.lastname: Bragstad
authors.forename: P H
authors.initials: PH
authors.lastname: Jørgensen
authors.forename: K J
authors.initials: KJ
authors.lastname: Handberg
authors.forename: A
authors.initials: A
authors.lastname: Fomsgaard
mesh_terms: D000818:Animals; D004372:Ducks / Q000821:virology; D005814:Genes, Viral; D016679:Genome, Viral; D053125:Influenza A Virus, H5N2 Subtype / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000821:virology*; D009439:Neuraminidase / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis / Q000302:isolation & purification; D016865:Reassortant Viruses; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral; D009439:Neuraminidase