title: Resistin, acute coronary syndrome and prognosis results from the AtheroGene study.
abstract: OBJECTIVE
  Resistin, an adipocyte and macrophage derived cytokine, causes insulin resistance and glucose intolerance. We investigated the impact of resistin as a diagnostic marker in patients with acute coronary syndrome and its prognostic value for future cardiovascular events.
  
  
  METHODS
  Resistin levels were determined in 1153 patients with stable angina (SAP), 380 patients with unstable angina, 278 patients with non-ST-elevation myocardial infarction (NSTEMI) and 111 patients with ST-elevation myocardial infarction (STEMI). All patients have been followed up for a median follow-up of 2.6 years. During follow-up, 70 patients died from cardiovascular causes.
  
  
  RESULTS
  Compared to SAP, resistin levels (5.1 ng/mL in SAP) were elevated in patients with angina at rest (5.89 ng/mL, P=0.001), in patients with NSTEMI (6.00 ng/mL, P<0.001), and in patients with STEMI (5.98 ng/mL, P<0.001). Resistin levels rose at 3-6h after chest pain onset (5.46 ng/mL), persisted elevated among those individuals presenting between 6 and 12h after chest pain onset (5.57 ng/mL) and peaked in individuals presenting more than 12h after chest pain onset (5.74 ng/mL). An increase of one standard deviation of resistin levels was associated with a 1.22-fold (95% CI 1.04-1.43; P=0.02) risk for future fatal cardiovascular events in a model adjusted for risk factors and clinical and therapeutic variables. When adjustment for renal function was applied, this association lost its statistical significance.
  
  
  CONCLUSIONS
  Resistin levels are elevated in patients presenting with unstable angina, NSTEMI and STEMI and might play a role as a diagnostic marker. In addition, systemic resistin level is moderately associated with future cardiovascular death in patients with documented coronary artery disease.
authors.affiliation: Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
authors.forename: Edith
authors.initials: E
authors.lastname: Lubos
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Messow
authors.forename: Renate
authors.initials: R
authors.lastname: Schnabel
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: Christine
authors.initials: C
authors.lastname: Espinola-Klein
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.forename: Dirk
authors.initials: D
authors.lastname: Peetz
authors.forename: Felix
authors.initials: F
authors.lastname: Post
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Lackner
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.forename: Thomas
authors.initials: T
authors.lastname: Münzel
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
mesh_terms: D000208:Acute Disease; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology; D011379:Prognosis; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D013577:Syndrome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids; C499624:RETN protein, human; D052243:Resistin