Androgen deprivation therapy and cardiac function: effects of endurance training.
OBJECTIVE
This study examined the effects of an 8-week androgen deprivation therapy treatment using Zoladex and an endurance training regimen on cardiac function.


METHODS
Male Sprague-Dawley rats received either Zoladex or placebo. Animals remained sedentary or endurance trained during the drug treatment period. On day 57, ex vivo cardiac function was analyzed.


RESULTS
Hearts from sedentary animals receiving Zoladex possessed significant cardiac dysfunction. However, hearts from exercise trained rats receiving Zoladex possessed cardiac function values similar to those from hearts from placebo animals.


CONCLUSIONS
An 8-week treatment with Zoladex promoted cardiac dysfunction. Endurance training during Zoladex treatment protected against this cardiac dysfunction.
Hydock
D S
DS
School of Sport and Exercise Science and the Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO, USA.
Wonders
K Y
KY
Schneider
C M
CM
Hayward
R
R
D000704:Analysis of Variance; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D003326:Coronary Circulation / Q000187:drug effects*; D003971:Diastole / Q000187:drug effects; D005080:Exercise Test; D017273:Goserelin / Q000494:pharmacology; D006321:Heart / Q000033:anatomy & histology; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018995:Myosin Heavy Chains / Q000096:biosynthesis / Q000187:drug effects; D009929:Organ Size; D010807:Physical Endurance / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013599:Systole / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood; D017725:Ventricular Pressure / Q000187:drug effects*
D018931:Antineoplastic Agents, Hormonal; D015415:Biomarkers; D017273:Goserelin; D013739:Testosterone; D018995:Myosin Heavy Chains