title: Microarrays and the microscope: balancing throughput with resolution.
abstract: The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.
authors.affiliation: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Coppola
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Geschwind
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000502:physiology; D003952:Diagnostic Imaging; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000235:genetics* / Q000502:physiology; D005819:Genetic Markers; D006801:Humans; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000166:cytology / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D005819:Genetic Markers