title: Oxide hemostatic activity.
abstract: The tunable in vitro blood clotting activity of high-surface-area hemostatic bioactive glass is evaluated by Thromboelastograph, a clinical instrument for quantifying changes in blood during coagulation. The hemostatic trends associated with hemostatic bioactive glass and a new preparation of spherical hemostatic bioactive glass, along with similar Si- and Ca-containing oxides, are described and related to Si:Ca ratios, Ca2+ availability and coordination environment, porosity, DeltaHHydration, and surface area. Hemostatic bioactive glass is a new material with an excellent efficacy for inducing hemostasis and is chemically distinct from the traditional bioglass employed for bone growth.
authors.affiliation: Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Ostomel
authors.forename: Qihui
authors.initials: Q
authors.lastname: Shi
authors.forename: Galen D
authors.initials: GD
authors.lastname: Stucky
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D002119:Calcium Carbonate / Q000737:chemistry / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D006490:Hemostatics / Q000737:chemistry* / Q000494:pharmacology; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D013916:Thrombelastography; D013997:Time Factors
chemical_list: D017610:Calcium Compounds; D006490:Hemostatics; D010087:Oxides; C509969:SBA-15; D012822:Silicon Dioxide; D017886:Durapatite; C016538:lime; D002119:Calcium Carbonate