title: Integrating adhesion, protrusion, and contraction during cell migration.
abstract: Cell migration is fastest when the strength of the adhesion between the cell and the substrate is neither too strong nor too weak. In this issue of Cell, reveal how adhesion and cytoskeletal dynamics are integrated to optimize migration speed.
authors.affiliation: Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. maschwartz@virginia.edu
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schwartz
authors.forename: Alan Rick
authors.initials: AR
authors.lastname: Horwitz
mesh_terms: D000199:Actins / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D015398:Signal Transduction; D013499:Surface Properties
chemical_list: D000199:Actins; D005353:Fibronectins; D016023:Integrins