title: Risk factors and characteristics of ocular complications, and efficacy of autologous serum tears after haematopoietic progenitor cell transplantation.
abstract: The objective of the study was to evaluate the frequency and clinical characteristics of ocular complications and their risk factors, as well as autologous serum tears (AST) for the treatment of dry eye in these patients. Data from the files of 124 patients who had undergone allogeneic haematopoietic progenitor cell transplantation (HPCT) were evaluated. In addition, 33 HPCT patients were examined and their data were compared with controls. Analysis of tears and AST was performed. Dry eye manifestation occurred in 32% of patients and was positively correlated with age over 27 years (P = 0.05), peripheral blood progenitor cell transplant (P = 0.002), chronic graft-versus-host disease (P = 0.0027), and chronic or acute myeloid leukaemia (P = 0.001). Dry mouth and Schirmer test < 5 mm were predictive factors for dry eye in HPCT patients (P = 0.002 and odds ratio 3.9 and P = 0.007, odds ratio = 5.9, respectively). Microbiological analysis revealed that six of 11 AST samples were contaminated after 30 days of use. The present study supports the role of potential risk factors for ocular complications and key elements to detect alterations in the tear film from HPCT patients. In addition, AST contamination must be considered after longer periods of use.
authors.affiliation: Department of Ophthalmology & Otorhinolaryngology, State University of Campinas, (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: S C
authors.initials: SC
authors.lastname: Leite
authors.forename: R S
authors.initials: RS
authors.lastname: de Castro
authors.forename: M
authors.initials: M
authors.lastname: Alves
authors.forename: D A
authors.initials: DA
authors.lastname: Cunha
authors.forename: M E P
authors.initials: ME
authors.lastname: Correa
authors.forename: L A
authors.initials: LA
authors.lastname: da Silveira
authors.forename: A C
authors.initials: AC
authors.lastname: Vigorito
authors.forename: C A
authors.initials: CA
authors.lastname: de Souza
authors.forename: E M
authors.initials: EM
authors.lastname: Rocha
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D015352:Dry Eye Syndromes / Q000188:drug therapy / Q000209:etiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D012307:Risk Factors; D044967:Serum
chemical_list: D009883:Ophthalmic Solutions