NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis.
BACKGROUND
Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases.


OBJECTIVE
To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-control study.


METHODS
Seventy-five patients with symptomatic collagenous colitis and 534 healthy blood donors were genotyped for SNP 8, 12, and 13 of the NOD2/CARD15 gene using TaqMan technology. Susceptibility to collagenous colitis was tested using Chi(2)-test comparing the carrier status of the rare allele.


RESULTS
The carrier frequency of the rare allele in SNP 8, 12, and 13 was 9.5, 1.3, and 8.1% in patients with collagenous colitis and 8.9, 1.1, and 8.4% in healthy blood donors, respectively. There were no significant differences in allele-, genotype, and carrier frequency (p>0.05).


CONCLUSIONS
Our data suggest that functional polymorphisms in the NOD2/CARD15 gene might not be involved in the susceptibility to collagenous colitis.
Madisch
Ahmed
A
Medical Department I, Technical University Hospital, Fetscherstr. 74, D-01307 Dresden, Germany. ahmed.madisch@uniklinikum-dresden.de
Hellmig
Stephan
S
Schreiber
Stephan
S
Bethke
Birgit
B
Stolte
Manfred
M
Miehlke
Stephan
S
D016022:Case-Control Studies; D016009:Chi-Square Distribution; D046729:Colitis, Collagenous / Q000209:etiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic
C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein