title: Phenytoin as an augmentation for SSRI failures: a small controlled study.
abstract: BACKGROUND
  Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures.
  
  
  METHODS
  Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings.
  
  
  RESULTS
  No effect was found.
  
  
  CONCLUSIONS
  This study was a small study.
  
  
  CONCLUSIONS
  Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.
authors.affiliation: Schonbaum Depression Department, Herzog Hospital, Jerusalem, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Shapira
authors.forename: B
authors.initials: B
authors.lastname: Nemets
authors.forename: A
authors.initials: A
authors.lastname: Trachtenberg
authors.forename: R H
authors.initials: RH
authors.lastname: Belmaker
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D003865:Major Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000008:administration & dosage / Q000009:adverse effects; D010555:Personality Inventory; D010672:Phenytoin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D005473:Fluoxetine; D016666:Fluvoxamine; D017374:Paroxetine; D010672:Phenytoin; D017367:Selective Serotonin Reuptake Inhibitors