A dietary supplement improves outcome in an experimental influenza model in old mice.
Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan-positive cells, lung and plasma lipoperoxides, and TNF-alpha in lung tissue increased during viral infection, but improvement was seen in the MMT-treated group (P < 0.05). MMT also normalized SOD, catalase activities, and ascorbic acid and determined a significant decrease of lung but not nasal viral titer, although nasal inflammatory infiltrate dropped significantly. MMT has potential clinical applications with and has an excellent safety profile even in old animals.
Cervi
J
J
SFJO Labs, Paris, France.
Marotta
F
F
Bater
C
C
Masulair
K
K
Minelli
E
E
Harada
M
M
Marandola
P
P
D000284:Administration, Oral; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002374:Catalase / Q000032:analysis; D018946:Chemokine CCL5 / Q000032:analysis; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D008168:Lung / Q000201:enzymology / Q000378:metabolism / Q000821:virology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000178:diet therapy* / Q000821:virology; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000032:analysis; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D019562:Viral Load
D000975:Antioxidants; D018946:Chemokine CCL5; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid