title: Repression of secondary metabolite production by exogenous cAMP in Monascus.
abstract: The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.
authors.affiliation: Industrial Technology Center of Okayama Prefecture, Haga, Okayama. tsuyoshi_miyake@pref.okayama.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyake
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Zhang
authors.forename: Isato
authors.initials: I
authors.lastname: Kono
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nozaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sammoto
mesh_terms: D000242:Cyclic AMP / Q000494:pharmacology*; D032741:Monascus / Q000187:drug effects* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000242:Cyclic AMP