title: False-positive restaging PET scans involving the spleen in two patients with aggressive non-Hodgkin lymphoma.
abstract: We report 2 patients with aggressive non-Hodgkin lymphoma who had positive restaging PET scans limited to the spleen and no significant uptake in nodal areas of previously known disease. Examination of the resected spleens from both patients revealed extensive inflammation surrounding necrotic tumor with no evidence of viable lymphoma or active infection. It is suggested that close observation of such patients for evidence of progressive disease may be considered as opposed to immediate intervention.
authors.affiliation: Department of Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA. clyde.ford@ihc.com
authors.forename: Clyde D
authors.initials: CD
authors.lastname: Ford
authors.forename: Frank
authors.initials: F
authors.lastname: Gabor
authors.forename: Ross
authors.initials: R
authors.lastname: Morgan
authors.forename: Bashar
authors.initials: B
authors.lastname: Dabbas
mesh_terms: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D002051:Burkitt Lymphoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D016190:Carboplatin; D003520:Cyclophosphamide; D003907:Dexamethasone; D018450:Disease Progression; D004317:Doxorubicin; D005047:Etoposide; D005189:False Positive Reactions; D006801:Humans; D007069:Ifosfamide; D010535:Laparoscopy; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009367:Neoplasm Staging / Q000379:methods; D049268:Positron-Emission Tomography; D011241:Prednisone; D012074:Remission Induction; D000069283:Rituximab; D016879:Salvage Therapy; D013154:Spleen / Q000000981:diagnostic imaging*; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D019564:Unnecessary Procedures; D014750:Vincristine
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D005047:Etoposide; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D007069:Ifosfamide; D011241:Prednisone