Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury.
OBJECTIVE
To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI).


METHODS
A prospective study of 35 mild TBI subjects presenting to the emergency department.


METHODS
Six hour serum S-100B and C-tau levels compared to 3-month Rivermead Post Concussion Questionnaire (RPCQ) scores and post-concussive syndrome (PCS).


RESULTS
The linear correlation between marker levels and RPCQ scores was weak (S-100B: r = 0.071, C-tau: r = -0.21). There was no statistically significant correlation between marker levels and 3-month PCS (S-100B: AUC = 0.589, 95%CI. 038, 0.80; C-tau: AUC = 0.634, 95%CI 0.43, 0.84). The sensitivity of these markers ranged from 43.8-56.3% and the specificity from 35.7-71.4%.


CONCLUSIONS
Initial serum S-100B and C-tau levels appear to be poor predictors of 3-month outcome after mild TBI.
Bazarian
Jeffrey J
JJ
Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, New York 14472, USA. jeff_barzarian@urmc.rochester.edu
Zemlan
Frank P
FP
Mookerjee
Sohug
S
Stigbrand
Torgney
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D038223:Post-Concussion Syndrome / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity; D015599:Trauma Severity Indices; D016875:tau Proteins
D015415:Biomarkers; C054369:MAPT protein, human; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D016875:tau Proteins