title: Case report:DNA testing resolves unusual results in the Dombrock system.
abstract: Typing for antigens in the Dombrock blood group system and identifying the corresponding antibodies are notoriously difficult tasks. The reagents are scarce and the antibodies are weakly reactive. When RBCs from family members of a patient with an antibody to a high-prevalence Dombrock antigen were tested for compatibility,an unusual pattern of inheritance was observed:RBCs from the patient's children and one niece, in addition to those from some of the patient's siblings,were compatible. This prompted the performance of DNA-based assays for DO alleles and the results obtained were consistent with and explained the compatibility test results. It was possible to study this large kindred because of the cooperation of family members, hospital personnel, and reference laboratory staff.
authors.affiliation: Baptist Memorial Hospital, Memphis, Tennessee, USA.
authors.forename: D
authors.initials: D
authors.lastname: MacFarland
authors.forename: K
authors.initials: K
authors.lastname: Hue-Roye
authors.forename: S
authors.initials: S
authors.lastname: Carter
authors.forename: D
authors.initials: D
authors.lastname: Moreau
authors.forename: J
authors.initials: J
authors.lastname: Barry
authors.forename: M K
authors.initials: MK
authors.lastname: Moulds
authors.forename: C
authors.initials: C
authors.lastname: Lomas-Francis
authors.forename: M E
authors.initials: ME
authors.lastname: Reid
mesh_terms: D036002:ADP Ribose Transferases / Q000235:genetics* / Q000276:immunology; D000483:Alleles; D001789:Blood Group Antigens / Q000235:genetics* / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D010375:Pedigree
chemical_list: D001789:Blood Group Antigens; D007518:Isoantibodies; D008565:Membrane Proteins; D036002:ADP Ribose Transferases; C105234:ART4 protein, human