[Expression and role of beta-catenin in acute leukemia bone marrow cells].
The aim of this study was to explore the expression of beta-catenin in acute leukemia bone marrow cells and its role in the development of acute leukemia. The expression of beta-catenin of bone marrow cells was detected by immunocytochemistry and flow cytometry in 20 cases of newly diagnosed acute leukemia. Meanwhile the expression of the proliferating index Ki-67 was detected by immunocytochemistry. The results showed that the expression of beta-catenin and Ki-67 in acute leukemia bone marrow cells was significantly higher than those in control group (P < 0.05). The migration of beta-catenin from cytoplasm to nuclear was observed in acute leukemia bone marrow cells. There was a positive correlation between the expressions of beta-catenin and Ki-67 in all the cases and the Pearson correlation coefficient was 0.845. In conclusion, the expression of beta-catenin was significantly high in acute leukemia bone marrow cells and showed a positive correlation with the cell proliferation. It suggests that beta-catenin may be involved in the development of acute leukemia through promoting the excessive proliferation of cells.
Chen
Sheng-Mei
SM
Department of Hematology, The First Affiliated Hospital, Zhengzhou University, Zhenzhou 450052, China.
Sun
Hui
H
Liu
Yan-Fang
YF
Zhang
Qiu-Tang
QT
D000208:Acute Disease; D001854:Bone Marrow Cells / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000032:analysis*
D019394:Ki-67 Antigen; D051176:beta Catenin