[Laboratory diagnoses of the first confirmed human case of avian influenza A (H5N1) in the mainland of China].
BACKGROUND
To determine the etiologic agent of an atypical pneumonia human case admitted to Xiangtan City hospital, Hunan Province in Oct. 2005.


METHODS
The patient's respiratory tract samples and serum were collected. Throat swabs were tested by microneutralization and hemagglutination-inhibition assays.


RESULTS
The results of nucleic acid detection of all respiratory samples were negative and virus isolation was also negative. The H5-specific antibodies of convalescence showed a 4-fold greater rise than acute phase.


CONCLUSIONS
The atypical pneumonias case was confirmed as the first human case of avian influenza A (H5N1) infection in the mainland of China.
Dong
Jie
J
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Control and Prevention, Beijing 100052, China.
Zhang
Hong
H
Liu
Yun-zhi
YZ
Zhang
Ye
Y
Wang
Min
M
Yu
Hong-jie
HJ
Yang
Wei-zhong
WZ
Xu
Cui-ling
CL
Xiang
Ni-juan
NJ
Li
Zhong-jie
ZJ
Chen
Yu-xu
YX
Guo
Yuan-ji
YJ
Li
De-xin
DX
Li
Jun-hua
JH
Wang
Yu
Y
Shu
Yue-long
YL
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002460:Cell Line; D002642:Chick Embryo; D002648:Child; D002681:China; D019411:Clinical Laboratory Techniques; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology; D008297:Male; D009500:Neutralization Tests; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000821:virology; D011933:Reagent Kits, Diagnostic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D011933:Reagent Kits, Diagnostic