[Hepatitis due to herpes group viruses].
In immunocompetent patients, primary infection by herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6, and Epstein-Barr virus (EBV) generally produces mild, self-limited hepatitis. Primary infection by HSV in neonates and pregnant women, and infection by VZV in hematological and bone marrow recipients can cause fulminant hepatitis without characteristic skin lesions. In liver transplant recipients, hepatitis is the most common expression of CMV infection and the related symptoms are indistinguishable from those of acute rejection. Persistent hepatitis is a manifestation of the syndrome of active chronic infection by the EBV. Fulminating hepatitis due to herpes virus can be treated effectively if therapy is started early; hence, a high degree of clinical suspicion and inclusion of herpes virus in the differential diagnosis of this syndrome is necessary.
Cisneros-Herreros
José M
JM
Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla, España. cisnerosjm@telefonica.net
Herrero-Romero
Marta
M
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications; D003587:Cytomegalovirus / Q000302:isolation & purification / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000150:complications; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000821:virology*; D006561:Herpes Simplex / Q000150:complications; D006564:Herpesviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification / Q000472:pathogenicity; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D015654:Herpesvirus 6, Human / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D018139:Simplexvirus / Q000302:isolation & purification / Q000472:pathogenicity
D000998:Antiviral Agents