Susceptibility of experimental animals to reinfection with Clonorchis sinensis.
The present study observed the resistance to reinfection with Clonorchis sinensis in various experimental animals including mice, guinea pigs, rabbits, and dogs, as well as rats and hamsters. The resistance rates to reinfection in rats, mice, hamsters, guinea pigs, rabbits, and dogs were 79.7%, 58.0%, -12.6%, 54.8%, 62.6%, and 6.0%, respectively. Worms recovered from reinfected rats and mice were immature, and significantly smaller than those from the primarily infected (P < 0.01), whereas those from other animals were fully matured to adults. These findings indicate that the protective response against reinfection with C. sinensis is prominent in rats and mice, and that they may be a good animal model to investigate the mechanism of resistance to reinfection with C. sinensis.
Sohn
Woon-Mok
WM
Department of Parasitology and Institute of Health Sciences, Gyeongsan National University College of Medicine, Jinju 660-751, Korea.
Zhang
Hongman
H
Choi
Min-Ho
MH
Hong
Sung-Tae
ST
D000818:Animals; D000830:Animals, Laboratory / Q000276:immunology / Q000469:parasitology*; D000871:Anthelmintics / Q000627:therapeutic use; D003003:Clonorchiasis / Q000188:drug therapy / Q000276:immunology; D003004:Clonorchis sinensis / Q000276:immunology / Q000502:physiology*; D006224:Cricetinae; D004285:Dogs; D006168:Guinea Pigs; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats
D000871:Anthelmintics; D011223:Praziquantel