A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer.
The aim of this study was to verify whether the use of bethanechol during radiotherapy (RT) for head and neck cancer (HNC) prevents radiation-induced xerostomia and salivary flow reduction. Patients that would begin RT were randomly allocated into bethanechol (group 1) or artificial saliva (group 2). Whole resting saliva (WRS) and whole stimulated saliva (WSS) were collected from all the patients at the following four stages: baseline, during, immediately after, and at least two months after the end of RT. Xerostomia was assessed by a subjective visual analogue scale (VAS), and by asking patients whether they felt dry mouth. Forty-three patients were randomized into this trial. The use of bethanechol during RT for HNC cancer was associated with significantly higher WRS immediately after RT (p=0.03) in comparison to a similar cohort of patients who had not received bethanechol.
Jham
Bruno Correia
BC
Department of Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av Antônio Carlos, 6627, Pampulha, Belo Horizonte, 31270-901 Minas Gerais, Brazil. brunocjham@yahoo.com.br
Teixeira
Inah Vanetti
IV
Aboud
Clarissa Gonçalves
CG
Carvalho
André Lopes
AL
Coelho
Márcio de Matos
Mde M
Freire
Addah Regina da Silva
AR
D000328:Adult; D000368:Aged; D018723:Bethanechol / Q000627:therapeutic use*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011878:Radiotherapy / Q000009:adverse effects; D012464:Saliva, Artificial / Q000627:therapeutic use; D012469:Salivary Glands / Q000293:injuries / Q000528:radiation effects*; D012472:Salivation / Q000187:drug effects / Q000528:radiation effects; D016896:Treatment Outcome; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control*
D012464:Saliva, Artificial; D018723:Bethanechol