Two novel immunosuppressive pregnane glycosides from the roots of Stephanotis mucronata.
Two novel pregnane glycosides, together with one new aglycone, were isolated from the roots of Stephanotis mucronata. Their structures were determined by means of chemical evidence and extensive spectroscopic methods including 1D and 2D NMR. The two pregnane glycosides displayed significant immunosuppressive activities in vitro.
Ye
Yiping
Y
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, PR China. yeyiping2005@163.com
Chen
Fengyang
F
Sun
Hongxiang
H
Li
Xiaoyu
X
Pan
Yuanjiang
Y
D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D006027:Glycosides; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D011278:Pregnanes; D003208:Concanavalin A