Identification of cis-acting regions that contribute to neuron-specific expression of the GAP-43 gene.
There are two transcription start sites in the growth-associated protein 43 (GAP-43) promoter, and several repressive elements have been reported in the control region. But the repressive effects have been analyzed only for the distal transcription start site. Among the repressive elements reported, we found that modulator I repressed GAP-43 gene expression from the proximal promoter in non-neuronal cells. We also found a novel stimulative element immediately downstream of modulator I.
Takahashi
Mikio
M
Department of Biotechnology, Graduate School of Engieering, Nagoya University.
Sato
Yoshitaka
Y
Nakagami
Yuki
Y
Miyake
Katsuhide
K
Iijima
Shinji
S
D000818:Animals; D002460:Cell Line; D019922:GAP-43 Protein / Q000235:genetics*; D017353:Gene Deletion; D005786:Gene Expression Regulation / Q000235:genetics*; D051379:Mice; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics
D019922:GAP-43 Protein