Dementia with cerebrovascular disease.
In this case study, we review the symptoms, cognitive testing, brain imaging, and brain pathology of a woman with dementia, for whom the neuropathological findings suggest a prominent contribution of cerebrovascular disease. Vascular dementia is the term commonly used for persons with dementia resulting from strokes, either clinically evident or subclinical "silent" events. "Mixed dementia" is the term used when there is an admixture of pathological findings related to Alzheimer's disease (AD) and cerebrovascular disease, as in this situation. In some cases of mixed dementia, the pathological involvement of AD may be the principal contributory cause of the cognitive symptoms, and in others, the vascular changes may give the greater contribution.
Wright
Clinton B
CB
Columbia University College of Physicians and Surgeons, Department of Neurology, New York, NY 10032, USA. CWright@neuro.columbia.edu
Vonsattel
Jean Paul G
JP
Bell
Karen
K
Honig
Lawrence S
LS
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000473:pathology; D003704:Dementia / Q000150:complications*; D004522:Educational Status; D005260:Female; D006801:Humans; D008487:Medical History Taking; D009460:Neurologic Examination