ApoB-100 and ApoB/ApoA-1 ratio in children and adolescents from families with very early myocardial infarction.
OBJECTIVE
The relationship between apolipoprotein B, LDL/ApoB, ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent <45 years) was studied in 46 children compared with 64 controls.


METHODS
19 children came out of families with a myocardial infarction (MI) of the father and 27 children with MI of a grandparent.


RESULTS
In the whole risk group LDL-C, ApoB and ApoB/ApoA-1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL-C and LDL/ApoB.


CONCLUSIONS
Our results show that levels of ApoB, LDL-C and ApoB/ApoA-1 might be better predictors in children from families of very early MI as compared with ApoA-1, HDL-C and LDL/ApoB.
Dirisamer
Albert
A
Department of Pediatrics, University of Vienna, Austria.
Stadler
Alfred
A
Bucek
Robert A
RA
Widhalm
Kurt
K
D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D053299:Apolipoprotein B-100 / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D002648:Child; D005190:Family; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D012016:Reference Values
D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B