Phosphonoacetic Acid inhibition of frog virus 3 replication.
Phosphonoacetic acid at concentrations above 200 mug/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or gamma polypeptides was also inhibited by phosphonoacetic acid, although the early (alpha and beta) polypeptides were unaffected.
Elliott
R M
RM
Unit of Invertebrate Virology, Natural Environment Research Council, and Department of Forestry, University of Oxford, Oxford, OX1 3UB, United Kingdom.
Bateson
A
A
Kelly
D C
DC