[Vitamin D and phosphate metabolism; relationship with aging-regulating gene].
It has been known that phosphate homeostasis is mainly regulated by parathyroid hormone and vitamin D. Fibroblast growth factor 23 (FGF23) has been identified as a novel factor that regulates vitamin D and phosphate metabolism. Genetic defect of FGF23 in mice revealed not only abnormal vitamin D and phosphate metabolism, but also premature aging-like phenotype that is quite similar to Klotho mice. Regulation of vitamin D and phosphate metabolism is closely related to aging processes as well as bone and mineral metabolism.
Taketani
Yutaka
Y
University of Tokushima Graduate School, Institute of Health Biosciences, Department of Clinical Nutrition.
Yamamoto
Hironori
H
Takeda
Eiji
E
Miyamoto
Ken-ichi
K
D000375:Aging / Q000235:genetics*; D019588:Aging, Premature / Q000235:genetics; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D051858:Forkhead Transcription Factors; D005966:Glucuronidase / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D000090265:Klotho Proteins; D051379:Mice; D010710:Phosphates / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014807:Vitamin D / Q000009:adverse effects / Q000378:metabolism / Q000502:physiology*
C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D051858:Forkhead Transcription Factors; D010710:Phosphates; D016226:Phosphorus, Dietary; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins