NK cell depletion and recovery in SCID mice treated with anti-NK1.1 antibody.
The anti-NK1.1 antibody produced by PK136 hybridoma cell line administered subcutaneously to SCID mice effectively decreased the level of peripheral blood NK cells and weight of the spleen for 3-4 days. The antibody treatment did not harm the general state of the animal, and may be practically applied in xenograft experiments.
Kulesza
Joanna
J
Department of Clinical Cytology, Medical Center of Postgraduate Education, Warszawa, Poland.
Hoser
Grazyna
G
Wasilewska
Danuta
D
Kawiak
Jerzy
J
D000818:Animals; D000906:Antibodies / Q000276:immunology* / Q000494:pharmacology*; D005434:Flow Cytometry; D007694:Killer Cells, Natural / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D016513:Mice, SCID; D009929:Organ Size; D013154:Spleen / Q000166:cytology
D000906:Antibodies