Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract.
Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type 1 knockout (IL-1R(1) KO) and normal wild type mice were intranasally infected with M. kansasii. IL-1R(1) KO mice demonstrated a reduced antibacterial response in the lungs and an increased dissemination to the liver, which was accompanied by an enhanced pulmonary inflammatory response. These data identify IL-1 as an important component of the innate immune response to lung infection by M. kansasii.
Wieland
Catharina W
CW
Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands. c.wieland@amc.uva.nl
Florquin
Sandrine
S
Pater
Jennie M
JM
Weijer
Sebastiaan
S
van der Poll
Tom
T
D000818:Animals; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008168:Lung / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology* / Q000382:microbiology; D019909:Mycobacterium kansasii / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology*; D053573:Receptors, Interleukin-1 Type I / Q000172:deficiency / Q000235:genetics / Q000276:immunology*
D007375:Interleukin-1; D053573:Receptors, Interleukin-1 Type I