Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors.
By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp.
Wangun
Hilaire V Kemami
HV
Dept. Biomolecular Chemistry, Leibniz-Institute for Natural Products Research and Infection Biology, Jena, Germany.
Härtl
Albert
A
Tam Kiet
Trinh
T
Hertweck
Christian
C
D001487:Basidiomycota / Q000737:chemistry*; D002852:Chromatography, Ion Exchange; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology*; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology*; D010666:Phenylpropionates / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D005663:Furans; D018942:Macrolides; D010666:Phenylpropionates; C513095:inotilone; D014969:Xanthine Oxidase