[Prognostic factors in patients with cervical--confined endometrial carcinoma treated with surgery and postoperative radiotherapy].
OBJECTIVE
The aim of the study was to determine prognostic factors in the group of the patients with uterine--confined endometrial carcinoma treated with surgery and postoperative radiotherapy.


METHODS
The authors analyzed 102 patients (mean age 58 years) with stage 1 (74 patients) and stage 11 (28 patients) endometrial carcinoma. All patients were treated with surgery (abdominal hysterectomy and bilateral adnexectomy) and postoperative radiotherapy: external beam pelvic irradiation (20 patients), vaginal cuff irradiation (33 patients) and combination (49 patients). Analysed were prognostic factors as follows: age, stage, tumor grade, depth of myometrial invasion, hormone receptors, expression of the tumor suppressor gene p53, Her 2/neu and MIB-1 (ki-67 paraffin).


RESULTS
In our group of patients, multivariate analysis has identified tumor grade, progesterone receptors status and MIB-1 as independent significant prognostic factors.
Karolewski
Kazimierz
K
Klinika Ginekologii Onkologicznej, Krakowskiego Oddziału Centrum Onkologii, Instytutu im. M. Skłodowskiej-Curie. z5karole@cyf-kr.edu.pl
Kojs
Zbigniew
Z
Jakubowicz
Jerzy
J
Urbański
Krzysztof
K
Reinfuss
Marian
M
Dymek
Paweł
P
Jóźwik
Piotr
P
D000368:Aged; D001918:Brachytherapy / Q000379:methods; D018269:Carcinoma, Endometrioid / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011044:Poland; D011182:Postoperative Care / Q000379:methods; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*