title: Visualization method to predict the nucleophilic asymmetric induction of prochiral electrophiles.
abstract: [reaction: see text] This work focuses on the development of a simple technique to accurately predict and visualize the diastereoselectivity of ketone, aldehyde, and allyl chloride reductions by mapping electrostatic potential onto the frontier molecular orbital involved in the reduction. A distinct difference of electrostatic potential on the faces of the carbonyl can be used to predict the face of nucleophilic attack with a high level of accuracy.
authors.affiliation: Department of Chemistry, University of California at Riverside, 92521, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Wilmot
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Marsella