title: Geroprotection by glycerol: insights to its mechanisms and clinical potentials.
abstract: Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed significant chaperoning activity in refolding heat-denatured luciferase in vivo and in protecting cells from heat stress-induced cytotoxicity. This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress.
authors.affiliation: National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan.
authors.forename: Custer C
authors.initials: CC
authors.lastname: Deocaris
authors.forename: Bhupal G
authors.initials: BG
authors.lastname: Shrestha
authors.forename: David C
authors.initials: DC
authors.lastname: Kraft
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Sunil C
authors.initials: SC
authors.lastname: Kaul
authors.forename: Suresh I S
authors.initials: SI
authors.lastname: Rattan
authors.forename: Renu
authors.initials: R
authors.lastname: Wadhwa
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D005990:Glycerol / Q000494:pharmacology* / Q000627:therapeutic use*; D050883:HSC70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D008136:Longevity / Q000187:drug effects; D008156:Luciferases / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D020673:Protein Renaturation / Q000187:drug effects
chemical_list: D050883:HSC70 Heat-Shock Proteins; D018832:Molecular Chaperones; D008156:Luciferases; D005990:Glycerol