The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.
Whitbread
Astrid K
AK
Hormone-Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, and Department of Urology, Princess Alexandria Hospital, Brisbane 4000, QLD, Australia.
Veveris-Lowe
Tara L
TL
Lawrence
Mitchell G
MG
Nicol
David L
DL
Clements
Judith A
JA
D004627:Embryonic Induction; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007610:Kallikreins / Q000502:physiology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000473:pathology; D010447:Peptide Hydrolases / Q000502:physiology; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000209:etiology / Q000473:pathology*
D010447:Peptide Hydrolases; D007610:Kallikreins