title: Synthesis and biological activity of amide derivatives of nimbolide.
abstract: Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.
authors.affiliation: Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad.
authors.forename: B S
authors.initials: BS
authors.lastname: Sastry
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: T
authors.initials: T
authors.lastname: Hari Babu
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: P V
authors.initials: PV
authors.lastname: Srinivas
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: J
authors.initials: J
authors.lastname: Madhusudana Rao
mesh_terms: D000577:Amides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D031601:Azadirachta / Q000378:metabolism; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry*; D008956:Models, Chemical; D010936:Plant Extracts / Q000378:metabolism; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000378:metabolism
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D036701:Limonins; D010936:Plant Extracts; C042198:nimbolide