Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.
BACKGROUND
A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN).


METHODS
In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers.


RESULTS
We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN.


CONCLUSIONS
These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
Brown
Kirsty M O
KM
University of Dundee, Department of Public Health, Dundee, United Kingdom. k.brown@chs.dundee.ac.uk
Bujac
Sarah R
SR
Mann
Evleen T
ET
Campbell
David A
DA
Stubbins
Michael J
MJ
Blundell
John E
JE
D000328:Adult; D000483:Alleles; D000856:Anorexia Nervosa / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics*; D017465:Receptors, Opioid, delta / Q000235:genetics*; D006113:United Kingdom / Q000453:epidemiology
D044346:Receptor, Serotonin, 5-HT1D; D017465:Receptors, Opioid, delta; D004247:DNA