Iridoid constituents of Tarenna attenuata.
Members of a rare type of iridoid with two alpha,beta-unsaturated acid units were isolated from the whole plant of Tarenna attenuata, including a new compound, tarennin (1), an extraction artifact, and seven new glucosides, tarenninosides A-G (2-8), together with two known iridoid glucosides, ixoside and 10-methylixoside. The structures of 1-8 were elucidated by analysis of spectroscopic data including HMQC, HMBC, 1H-1H COSY, and ROESY NMR spectra and by comparison with known analogues. Antioxidant and cytotoxic activities were evaluated for these 10 compounds, but none showed positive activity.
Yang
Xian-Wen
XW
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Ma
Yan-Ling
YL
He
Hong-Ping
HP
Wang
Yue-Hu
YH
Di
Ying-Tong
YT
Zhou
Hua
H
Li
Ling
L
Hao
Xiao-Jiang
XJ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D039823:Iridoids