title: Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation.
abstract: BACKGROUND
  Advances in transplantation medicine are linked to improved efficacy of immunosuppressive agents. At the same time, these agents endanger medical success by side effects that may impair survival and quality of life (QOL). This study examined whether conversion to tacrolimus-based immunosuppression due to cyclosporine-related side effects improved. QOL in patients after kidney transplantation.
  
  
  METHODS
  In total 64 patients (29 men) with an average age of 51 years (SD+/-12) who had received a kidney allograft an average of 5.6 years (SD+/-4) before conversion participated. The reasons for conversion were cardiovascular/metabolic (n=26) or periodontal/dermatological side effects (n=38) of cyclosporine therapy. QOL was assessed before conversion and in average 7 months thereafter by a global (SF-36) and a disease-specific instrument (ESRD-SCL).
  
  
  RESULTS
  Disease-specific QOL (ESRD-SCL, global index) improved significantly (P<.001, explanation of variance [EV]=16.6%) after conversion from cyclosporine to tacrolimus. In detail, cardiac and renal dysfunction (P<.01, EV=12.9%) as well as increased growth of gum and hair (P<.0001, EV=53.2%) were significantly reduced at end of the study. However, global QOL (SF-36) remained unchanged.
  
  
  CONCLUSIONS
  Regardless of the indication (cardiovascular or cosmetic), switching to tacrolimus due to cyclosporine-related side effects improved disease-specific QOL within the short term.
authors.affiliation: University of Applied Sciences Magdeburg-Stendal, Rehabilitation Psychology, Stendal, Germany.
authors.forename: G H
authors.initials: GH
authors.lastname: Franke
authors.forename: C
authors.initials: C
authors.lastname: Trampenau
authors.forename: J
authors.initials: J
authors.lastname: Reimer
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D011788:Quality of Life; D013315:Stress, Psychological; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus