title: New trends in hair analysis and scientific demands on validation and technical notes.
abstract: This review focuses on basic aspects of method development and validation of hair testing procedures. Quality assurance is a major issue in drug testing in hair resulting in new recommendations, validation procedures and inter-laboratory comparisons. Furthermore recent trends in research concerning hair analysis are discussed, namely mechanisms of drug incorporation and retention, novel analytical procedures (especially ones using liquid chromatography-mass spectrometry (LC-MS) and alternative sample preparation techniques like solid-phase microextraction (SPME)), the determination of THC-COOH in hair samples, hair testing in drug-facilitated crimes, enantioselective hair testing procedures and the importance of hair analysis in clinical trials. Hair testing in analytical toxicology is still an area in need of further research.
authors.affiliation: Institute of Forensic Medicine, University of Bonn, Germany. f.musshoff@uni-bonn.de
authors.forename: Frank
authors.initials: F
authors.lastname: Musshoff
authors.forename: Burkhard
authors.initials: B
authors.lastname: Madea
mesh_terms: D053593:Forensic Toxicology / Q000379:methods* / Q000639:trends; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006801:Humans; D011786:Quality Control; D015203:Reproducibility of Results; D012106:Research / Q000639:trends; D015813:Substance Abuse Detection / Q000379:methods