Effect of rosiglitazone on embryonic growth and morphology: a study using a whole rat embryo culture model.
The effects of various concentrations of rosiglitazone on in vitro rat embryo growth and morphology during the critical period of organogenesis was evaluated. We found that rosiglitazone has no significant effects on growth and morphology of in vitro early embryo development, even at very high concentrations.
Chan
Louis Yik-Si
LY
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. chanysl@ha.org.hk
Lau
Tze Kin
TK
D000818:Animals; D004305:Dose-Response Relationship, Drug; D046149:Embryo Culture Techniques; D004622:Embryo, Mammalian / Q000033:anatomy & histology* / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D038081:Organogenesis / Q000187:drug effects; D051381:Rats; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone