title: [Bronchial challenges in asthma diagnosis].
abstract: The evaluation of bronchial hyperreactivity is useful for diagnosis atypical form asthma, in monitoring of anti-inflammatory treatment, in epidemiology and in scientific research. Different stimuli indirect and direct are applied to asses bronchial reactivity. Direct stimuli e.g. methacholine and histamine cause airway limitation by acting on airway smooth muscle. By contrast indirect stimuli (exercise, nonisotonic aerosols, adenosine, mannitol) cause airway limitation by acting inflammatory cells and neuronal cells which release mediators to cause secondary broncho-constriction. Bronchial challenges with direct stimuli are less sensitivity but more specific than the direct challenges in differentiating asthma from normal.
authors.affiliation: Klinika Alergologii i Pulmonologii, Instytut Gruźlicy i Chorób Płuc, Oddział w Rabce-Zdrój.
authors.forename: Iwona
authors.initials: I
authors.lastname: Sak
authors.forename: Ryszard
authors.initials: R
authors.lastname: Kurzawa
authors.forename: Agata
authors.initials: A
authors.lastname: Nowosielska
mesh_terms: D001249:Asthma / Q000175:diagnosis*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D001985:Bronchial Provocation Tests / Q000379:methods*; D016085:Bronchoconstrictor Agents; D019091:Critical Pathways; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D014797:Vital Capacity / Q000502:physiology
chemical_list: D016085:Bronchoconstrictor Agents