Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population.
OBJECTIVE
To assess the association between the single nucleotide polymorphism of the insulin receptor (INSR) gene and polycystic ovary syndrome (PCOS) in a Korean population.


METHODS
Case-control study.


METHODS
University-based hospital.


METHODS
One hundred seventy-four patients with PCOS and 93 healthy women as controls.


METHODS
Frequency of three genotypes for single nucleotide polymorphism found in exon 17 of INSR gene.


RESULTS
The high frequency of the T allele was shown both in patient and control groups. The frequency of C allele, which known as a normal allele, was slightly higher in the patient group than in the control group.


CONCLUSIONS
The C/T polymorphism in exon 17 of the INSR gene is not associated with susceptibility of PCOS in a Korean population.
Lee
Eung-Ji
EJ
Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Fertility Medical Center, Pochon CHA University, CHA General Hospital, Kangnam-Gu, Seoul 135-081, Korea.
Yoo
Kyong-Jai
KJ
Kim
So-Jeong
SJ
Lee
Sook-Hwan
SH
Cha
Kwang Yul
KY
Baek
Kwang-Hyun
KH
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003596:Cytosine; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011972:Receptor, Insulin / Q000235:genetics*; D013941:Thymine
D003596:Cytosine; D011972:Receptor, Insulin; D013941:Thymine