title: Effect of ciprofibrate on platelet aggregation in patients with combined hyperlipidemia.
abstract: This study was designed to investigate the effect of ciprofibrate on platelet aggregation in patients with combined hyperlipidaemia. Platelet aggregation measurements in platelet-rich plasma were carried out in 30 patients using the Biola 230 LA platelet aggregation analyser before treatment, 4 weeks and 8 weeks after ciprofibrate (100 mg/day) therapy. A control group consisted of 37 healthy subjects. We found that spontaneous and 0.25 microM ADP-induced platelet aggregation were significantly decreased after 4-weeks of therapy, from 4.6 to 3.2% and from 11.3 to 7.6% , respectively. However, there was no difference 8 weeks after the treatment onset. Platelet aggregation induced by adrenaline was unchanged during the ciprofibrate therapy.
authors.affiliation: Department of Cardiology, Tartu University Hospital, Estonia.
authors.forename: M
authors.initials: M
authors.lastname: Viigimaa
authors.forename: R
authors.initials: R
authors.lastname: Välkman
authors.forename: A
authors.initials: A
authors.lastname: Kask
authors.forename: T
authors.initials: T
authors.lastname: Jôudu