Structure and function of the components of the human DNA mismatch repair system.
DNA mismatch repair (MMR) is one of the several enzyme systems involved in DNA homeostasis. DNA MMR is involved in the repair of specific types of errors that occur during new DNA synthesis; loss of this system leads to an accelerated accumulation of potential mutations, and predisposes to certain types of cancers. Germline mutations in some of the DNA MMR genes cause the hereditary cancer predisposition, Lynch syndrome. This review addresses advances in the biochemistry of DNA MMR and its relationship to carcinogenesis.
Jascur
Thomas
T
Department of Internal Medicine, Baylor Research Institute, Baylor University Medical Center, Dallas, TX 75246, USA. thomasja@baylorhealth.edu
Boland
C Richard
CR
D000818:Animals; D017209:Apoptosis; D020137:Base Pair Mismatch; D001483:Base Sequence; D002453:Cell Cycle; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004260:DNA Repair; D006706:Homeostasis; D006801:Humans; D009690:Nucleic Acid Conformation
D004247:DNA