title: Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions.
abstract: The effects of the aqueous extract of Cistus ladaniferus leaves and stems were studied on the rodent isolated jejunum. The extract produced a reversible concentration dose-dependent (0.1-3 mg/ml) inhibition of the spontaneous motility of the rabbit jejunum. The inhibitory effects of the extract were not affected by pretreatment with the inhibitors of the alpha and beta adrenergic receptors yohimbine, prazosin or propranolol. The extract also inhibited K(+)-induced contractions in rabbit and rat jejunum at a similar concentration range. This result suggests that the antispasmodic action of the extract is mediated through calcium channel blockade. The results confirm the traditional use of C. ladaniferus in treating intestinal ache.
authors.affiliation: Laboratoire de Physiologie Ethnopharmacologie, UFR "Physiologie et Pharmacologie" Département de Biologie, Université Mohamed Premier, Faculté des Sciences, BP 717, 60000 Oujda, Morocco. azizmo5@yahoo.fr
authors.forename: Mohammed
authors.initials: M
authors.lastname: Aziz
authors.forename: Naoual
authors.initials: N
authors.lastname: Tab
authors.forename: Ahmed
authors.initials: A
authors.lastname: Karim
authors.forename: Hassane
authors.initials: H
authors.lastname: Mekhfi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bnouham
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Ziyyat
authors.forename: Ahmed
authors.initials: A
authors.lastname: Melhaoui
authors.forename: Abdelkhaleq
authors.initials: A
authors.lastname: Legssyer
mesh_terms: D000818:Animals; D029758:Cistus; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects*; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010276:Parasympatholytics; D010936:Plant Extracts