Lessons from a crab: molecular mechanisms in different memory phases of Chasmagnathus.
Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the molecular mechanisms involved in such processes, we used the context-signal associative learning paradigm of the crab Chasmagnathus. In this model, we studied the role of some molecular mechanisms, namely cAMP-dependent protein kinase (PKA), extracellular-signal-regulated kinase (ERK), the nuclear factor kappa B (NF-kappaB) transcription factor, and the role of synaptic proteins such as amyloid beta precursor protein, with the object of describing key mechanisms involved in memory processing. In this article we review the most salient results obtained over a decade of research in this memory model.
Romano
Arturo
A
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. IFIByNE, CONICET, Buenos Aires, Argentina. aromano@fbmc.fcen.uba.ar
Locatelli
Fernando
F
Freudenthal
Ramiro
R
Merlo
Emiliano
E
Feld
Mariana
M
Ariel
Pablo
P
Lemos
Darío
D
Federman
Noel
N
Fustiñana
Maria Sol
MS
D016564:Amyloid beta-Protein Precursor / Q000502:physiology; D000818:Animals; D003386:Brachyura / Q000378:metabolism / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D008568:Memory / Q000502:physiology*; D023421:Models, Animal; D008959:Models, Neurological; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction; D009435:Synaptic Transmission
D016564:Amyloid beta-Protein Precursor; D016328:NF-kappa B; D017868:Cyclic AMP-Dependent Protein Kinases; D048049:Extracellular Signal-Regulated MAP Kinases