Safety of argon plasma coagulation for hemostasis during endoscopic mucosal resection.
Showing the safety of argon plasma coagulation (APC) over mucosal defects during/after endoscopic mucosal resection (EMR), 2 studies using resected pig (ex vivo) and living minipig (in vivo) stomachs were performed. As an ex vivo study, APC was applied over mucosal defects in 2 groups; with prior submucosal saline injection and without injection. Only subtle tissue damage was observed in the injection group, whereas apparent damage was observed in the noninjection group. The damaged distances in depth significantly increased as the pulse duration increased and those at the pulse duration of 4 seconds, which might be maximal in clinical practice, were approximately 1 mm. As an in vivo study, APC was applied over mucosal defects immediately after EMR. Only subtle tissue damage was observed even at the pulse duration of 20 seconds as shown in the ex vivo study. APC can be performed safely over the mucosal defects during/after EMR.
Fujishiro
Mitsuhiro
M
Department of Gastroenterology, Graduate school of Medicine, University of Tokyo, Tokyo, Japan. mtfujish-kkr@umin.ac.jp
Yahagi
Naohisa
N
Nakamura
Masanori
M
Kakushima
Naomi
N
Kodashima
Shinya
S
Ono
Satoshi
S
Kobayashi
Katsuya
K
Hashimoto
Takuhei
T
Yamamichi
Nobutake
N
Tateishi
Ayako
A
Shimizu
Yasuhito
Y
Oka
Masashi
M
Ichinose
Masao
M
Omata
Masao
M
D000818:Animals; D001128:Argon; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004564:Electrocoagulation / Q000295:instrumentation*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000473:pathology*; D016558:Hemostasis, Endoscopic / Q000295:instrumentation*; D013552:Swine; D013556:Swine, Miniature
D001128:Argon