title: Cox-2 expression on tissue microarray of breast cancer.
abstract: OBJECTIVE
  To measure cyclooxygenase-2 (Cox-2) expression in a series of breast cancers and evaluate its potential as a predictive marker for doxorubicin chemotherapy.
  
  
  METHODS
  Cox-2 expression was analyzed in 178 node-positive patients treated with doxorubicin-based adjuvant chemotherapy by immunohistochemistry on tissue microarray (TMA).
  
  
  RESULTS
  Cox-2 was over-expressed in 70 out of the 178 invasive breast cancers. Cox-2 expression was significantly increased in undifferentiated tumors. There was no significant association between Cox-2 over-expression and tumor size, histologic grade, and estrogen receptor expression. Disease-free survival and overall survival of the patients having Cox-2 expressing tumor were significantly decreased when compared with the patients having Cox-2 negative tumor (p=0.009 for DFS, p=0.011 for OS).
  
  
  CONCLUSIONS
  Cox-2 expression may represent an aggressive phenotype of breast cancer which is resistant to doxorubicin.
authors.affiliation: Department of Pathology, Inje University, Sanggye Paik Hospital, 761-1, Sanggye-dong, Nowon-gu, Seoul 139-707, South Korea.
authors.forename: K
authors.initials: K
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Han
authors.forename: E
authors.initials: E
authors.lastname: Shin
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001365:Axilla; D001943:Breast Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D015409:Mastectomy, Radical; D008875:Middle Aged; D010641:Phenotype; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D051546:Cyclooxygenase 2