title: Family history of irritable bowel syndrome is the major determinant of persistent abdominal complaints in young adults with a history of pediatric recurrent abdominal pain.
abstract: OBJECTIVE
  To assess the late outcome of teen-agers with a previous history of recurrent abdominal pain (RAP) or irritable bowel syndrome (IBS).
  
  
  METHODS
  A group of 67 children with RAP referred to the department from January 1986 to December 1995 was followed up between 5 and 13 years after the initial diagnosis by means of a structured telephone interview. We hypothesized that those patients with persistent adult IBS-like symptoms would be significantly more likely to report a family history of IBS in comparison with adults with no persistent abdominal complaint.
  
  
  RESULTS
  Out of the 52 trackable subjects, 15 were found to present IBS-like symptoms at follow-up (29%) whereas the majority (37 subjects) did not. Subjects with IBS-like symptoms were almost three times more likely to present at least one sibling with similar symptoms compared to subjects not complaining (40.0% vs 16.0%), respectively (P < 0.05 at Student t test). Subjects with IBS-like symptoms also reported a higher prevalence of extra-intestinal symptoms, such as back pain, fibromyalgia, headache, fatigue and sleep disturbances.
  
  
  CONCLUSIONS
  The study confirms previous observations indicating that pediatric RAP can predict later development of IBS. The latter appears to be greatly influenced by intrafamilial aggregation of symptoms, possibly through the learning of a specific illness behavior.
authors.affiliation: Gastroenterology Department, University Hospital L. Sacco-Milan, Italy. cn.fapac@tin.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Pace
authors.forename: Giovanna
authors.initials: G
authors.lastname: Zuin
authors.forename: Stefania
authors.initials: S
authors.lastname: Di Giacomo
authors.forename: Paola
authors.initials: P
authors.lastname: Molteni
authors.forename: Valentina
authors.initials: V
authors.lastname: Casini
authors.forename: Massimo
authors.initials: M
authors.lastname: Fontana
authors.forename: Gabriele Bianchi
authors.initials: GB
authors.lastname: Porro
mesh_terms: D015746:Abdominal Pain / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D012008:Recurrence; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome