Visuospatial working memory deficits in adolescent onset schizophrenia.
This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while mid-dorsolateral and ventrolateral PFC functions remain intact: the current conceptualisation of schizophrenia as a progressive neurodevelopmental disorder is consistent with these results.
Vance
A
A
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, 3052, Victoria, Australia. avance@unimelb.edu.au
Hall
N
N
Bellgrove
M A
MA
Casey
M
M
Karsz
F
F
Maruff
P
P
D000293:Adolescent; D017668:Age of Onset; D002648:Child; D003342:Corpus Striatum / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D009415:Nerve Net / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D012559:Schizophrenia / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*