title: Restricted expression of Fgf16 within the developing chick inner ear.
abstract: Fibroblast growth factor (FGF) signaling is required for otic placode induction and patterning of the developing inner ear. We have cloned the chick ortholog of Fgf16 and analyzed its expression pattern in the early chick embryo. Expression is restricted to the otic placode and developing inner ear through all the stages examined. By the closed otocyst stage, expression has resolved to anterior and posterior domains that partially overlap with those of bone morphogenetic protein 4 (Bmp4), a marker of the developing sensory patches, the cristae of the anterior and posterior semicircular canals. Platelet-derived growth factor alpha (PDGFA), another growth factor with restricted otic expression, also overlaps with Fgf16 expression. The restricted expression pattern of Fgf16 suggests a role for FGF signaling in the patterning of the sensory cristae, together with BMP signaling.
authors.affiliation: University of Utah, School of Medicine, Department of Neurobiology and Anatomy, and Children's Health Research Center, Salt Lake City, Utah 84132, USA. susan.chapman@utah.edu
authors.forename: Susan C
authors.initials: SC
authors.lastname: Chapman
authors.forename: Qin
authors.initials: Q
authors.lastname: Cai
authors.forename: Steven B
authors.initials: SB
authors.lastname: Bleyl
authors.forename: Gary C
authors.initials: GC
authors.lastname: Schoenwolf
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000235:genetics; D002642:Chick Embryo; D003001:Cloning, Molecular; D007758:Ear, Inner / Q000737:chemistry / Q000196:embryology* / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: C525809:BMP4 protein, human; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; D005346:Fibroblast Growth Factors