[The influence of dehydroepiandrosterone sulfate on the extinction of passive avoidance in aggressive and submissive mice].
The effects of dehydroepiandrosterone sulfate (DHEAS) on the extinction of passive avoidance was studied on C57Bl/6J mice with aggressive and submissive behavioral stereotypes. Administered in a single dose 30 mg/kg one day or one hour before training, DHEAS selectively blocked the extinction of the conditioned habit in submissive mice, thus favoring its retrieval. The probable mechanism of this phenomenon can be related to a decrease in the level of inhibiting control in the GABAergic system.
Dubrovina
N I
NI
Tomilenko
R A
RA
Obut
T A
TA
D000374:Aggression; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D019314:Dehydroepiandrosterone Sulfate