Preparation and application of HPLC chiral stationary phases based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.
Preparation of liquid chromatographic chiral stationary phases (CSPs) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid and their application are reviewed. The various methods of connecting (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to silica gel covalently or dynamically are demonstrated. The CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid have been very successful for the resolution of various primary amino compounds with the use of an aqueous mobile phase containing organic and acidic modifiers. In addition, the resolution of secondary amino compounds including beta-blockers and N-(3,5-dinitrobenzoyl)-alpha-amino acids has been demonstrated on a CSP based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid with a non-aqueous mobile phase.
Hyun
Myung Ho
MH
Department of Chemistry, Chemistry Institute for Functional Materials, Pusan National University, Busan, Republic of Korea. mhhyun@pusan.ac.kr
D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000302:isolation & purification; D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D043844:Crown Ethers / Q000737:chemistry*; D015394:Molecular Structure; D012822:Silicon Dioxide; D013237:Stereoisomerism; D013816:Thermodynamics
D000319:Adrenergic beta-Antagonists; D000596:Amino Acids; D043844:Crown Ethers; C021611:aminopropyl silica gel; C090732:18-crown-6 2,3,11,12-tetracarboxylic acid; D012822:Silicon Dioxide