A novel protein, Romo1, induces ROS production in the mitochondria.
The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in the mitochondria. Romo1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy.
Chung
Young Min
YM
Graduate School of Medicine, Korea University College of Medicine, Korea University, Anam-dong, Sungbuk-ku, Seoul, Republic of Korea.
Kim
Jun Suk
JS
Yoo
Young Do
YD
D000818:Animals; D002460:Cell Line; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; C513338:ROMO1 protein, human; D017382:Reactive Oxygen Species; C513339:Romo1 protein, mouse