[The relationship between the Wnt signaling and the psychiatric diseases].
It has been demonstrated that the neuronal plasticity and resilience could participate in the pathophysiology of neurodegenerative diseases such as Alzheimer and others like depression and schizophrenia. Recently, it has been proposed a new intracellular pathway, known as Wnt pathway, which could be related to the induction of the plastic changes mentioned above. The glycogen synthase kinase-3beta (GSK-3beta), one of the main enzymes of the Wnt signaling, has been associated to Alzheimer;s and schizophrenia diseases etiology. Furthermore, the mood stabilizing agents;s action mechanism, like lithium and valproic acid, implies the inhibition of this protein. The issue of this work is to describe the proteins that are recruited when this pathway is activated and the GSK-3beta role in the pathologies mentioned.
Ferrero
Alejandro
A
Instituto de Investigación farmacológico, Conicet, Argentina. aferrero@ffyb.uba.ar
Cereseto
Marina
M
Sifonios
Laura
L
D000544:Alzheimer Disease / Q000201:enzymology / Q000503:physiopathology*; D003863:Depression / Q000201:enzymology / Q000503:physiopathology*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D012559:Schizophrenia / Q000201:enzymology / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors; D051153:Wnt Proteins / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology
D014157:Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3