Impact of bilateral pallidal stimulation on DYT1-generalized dystonia in Japanese patients.
Early-onset generalized dystonia attributable to a DYT1 gene mutation is a hyperkinetic movement disorder that responds poorly to pharmacotherapy. In this video brief, we show that continuous bilateral stimulation of the globus pallidus internus produced sustained and marked improvements in the motor symptoms and functional disabilities of Japanese patients with DYT1-generalized dystonia.
Goto
Satoshi
S
Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. sgoto@kaiju.medic.kumamoto-u.ac.jp
Yamada
Kazumichi
K
Shimazu
Hideki
H
Murase
Nagako
N
Matsuzaki
Kazuhito
K
Tamura
Tetsuya
T
Nagahiro
Shinji
S
Kuratsu
Jun-ichi
J
Kaji
Ryuji
R
D000293:Adolescent; D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D046690:Deep Brain Stimulation / Q000379:methods*; D004185:Disability Evaluation; D004292:Dominance, Cerebral / Q000502:physiology; D004421:Dystonia / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D007564:Japan; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics*; D018911:Trinucleotide Repeats
D018832:Molecular Chaperones; C108175:TOR1A protein, human