Autoimmunity in myocardial infarction.
Myocardial infarction is associated with an immune response. Physiological inflammation response causes self-repair and protection, while pathological autoimmune response leads to ventricular remodeling and heart failure. Laying emphasis on regulating the immune function may become a new target for the prevention of heart failure after myocardial infarction. This review focuses on the mechanism of immune-mediated ventricular remodeling and the immune therapy after myocardial infarction.
Liao
Yu-Hua
YH
Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China. liaoyh27@163.com
Cheng
Xiang
X
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002454:Cell Differentiation / Q000276:immunology; D049109:Cell Proliferation; D006333:Heart Failure / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D018836:Inflammation Mediators / Q000378:metabolism; D009203:Myocardial Infarction / Q000150:complications / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D020257:Ventricular Remodeling / Q000276:immunology
D001324:Autoantigens; D018836:Inflammation Mediators