title: [Genomic S segment of Crimean-Congo hemorrhagic fever virus circulating in Russia and Bulgaria].
abstract: S-segment nucleotide sequences for two Crimean-Congo hemorrhagic fever (CCHF) virus strains isolated in the Rostov Region of Russia and in Bulgaria have been determined. Analysis of complete S-segment nucleotide sequences in the viral strains from different regions of the world has established that the CCHF virus strains isolated from ticks and human beings in different southern Russian regions in 1967 and 2000 are very closely genetically and they form an individual subgroup in the basic European genetic group. By the S-segment structure, the CCHF virus strain isolated in Bulgaria in 1978 belongs to the same genetic group as a representative of its second subgroup. Analysis of the S-segment 3'-noncoding region suggests that the CCHF virus circulating in Europe, Central Asia, and China may have originated from one global focus of infection, including several CCHF virus genovariants. During evolution, fragmental exchange apparently occurred in the S-segment 3'-noncoding region as a result of homological recombination.
authors.forename: S V
authors.initials: SV
authors.lastname: Seregin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Tumanova
authors.forename: I D
authors.initials: ID
authors.lastname: Petrova
authors.forename: L N
authors.initials: LN
authors.lastname: Iashina
authors.forename: I I
authors.initials: II
authors.lastname: Kuzina
authors.forename: O I
authors.initials: OI
authors.lastname: Vyshemirskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Gutorov
authors.forename: S S
authors.initials: SS
authors.lastname: Seregin
authors.forename: G I
authors.initials: GI
authors.lastname: Tiunnikov
authors.forename: E I
authors.initials: EI
authors.lastname: Samokhvalov
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
authors.forename: V S
authors.initials: VS
authors.lastname: Petrov
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D002031:Bulgaria; D036022:Capsid Proteins / Q000235:genetics; D016679:Genome, Viral; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000235:genetics*; D006479:Hemorrhagic Fever, Crimean / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012426:Russia; D016415:Sequence Alignment; D013987:Ticks / Q000821:virology
chemical_list: D020413:3' Untranslated Regions; D036022:Capsid Proteins