title: Object perception impairments predict instrumental activities of daily living dependence in Alzheimer's disease.
abstract: This study examined the contribution of object perception and spatial localization to functional dependence among Alzheimer's disease (AD) patients. Forty patients with probable AD completed measures assessing verbal recognition memory, working memory, object perception, spatial localization, semantic knowledge, and global cognition. Primary caregivers completed a measure of activities of daily living (ADLs) that included instrumental and basic self-care subscales (i.e., IADLs and BADLs, respectively). Stepwise multiple regressions revealed that global cognition accounted for significant portions of variance among the ADL total, IADL, and BADL scores. However, when global cognition was removed from the model, object perception was the only significant cognitive predictor of the ADL total and IADL subscale scores, accounting for 18.5% and 19.3% of the variance, respectively. When considering multiple cognitive components simultaneously, object perception and the integrity of the inferotemporal cortex is important in the completion of functional abilities in general and IADLs in particular among AD patients.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadellphia, PA, USA. angelaj@bu.edu
authors.forename: Angela L
authors.initials: AL
authors.lastname: Jefferson
authors.forename: Lamia P
authors.initials: LP
authors.lastname: Barakat
authors.forename: Tania
authors.initials: T
authors.lastname: Giovannetti
authors.forename: Robert H
authors.initials: RH
authors.lastname: Paul
authors.forename: Guila
authors.initials: G
authors.lastname: Glosser
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010465:Perception / Q000502:physiology*; D010468:Perceptual Disorders / Q000209:etiology* / Q000523:psychology; D012044:Regression Analysis; D013037:Spatial Behavior / Q000502:physiology*