title: A cholinergic receptor gene (CHRM2) affects event-related oscillations.
abstract: We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4-5 Hz) was analyzed. Studies have shown that similar electrophysiological measures represent cognitive correlates of attention, working memory, and response selection; a role has been suggested for the ascending cholinergic pathway in the same functions. The results of our genetic association tests, combined with knowledge regarding the presence of presynaptic cholinergic M2 autoreceptors in the basal forebrain, indicate that the cognitive processes required by the experiment may in part be mediated by inhibitory neural networks. These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders.
authors.affiliation: Department of Psychiatry, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA. bp@cns.hscbklyn.edu
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Jones
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Laura
authors.initials: L
authors.lastname: Bierut
authors.forename: Danielle
authors.initials: D
authors.lastname: Dick
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
authors.forename: Lance O
authors.initials: LO
authors.lastname: Bauer
authors.forename: Raymond
authors.initials: R
authors.lastname: Crowe
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Sean J
authors.initials: SJ
authors.lastname: O'Connor
authors.forename: John
authors.initials: J
authors.lastname: Rohrbaugh
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Jay
authors.initials: J
authors.lastname: Tischfield
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D002874:Chromosome Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D043585:Receptor, Muscarinic M2 / Q000235:genetics*
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2