title: Does a reduction of adhesion molecules by LDL-apheresis have a role in the treatment of sudden hearing loss?
abstract: Sudden hearing loss (SHL) is a highly disabling affliction that can severely affect the subject's social and relational life. Although the etiology of the complaint is still debated, it is thought that microcirculation disturbances conditioned by an endothelial dysfunction might be the main pathogenetic mechanism. Adhesion molecules favoring interaction between leukocytes and endothelial cells are early markers of endothelial damage. In the present report, we describe a case of SHL that derived evident benefit from a single session of LDL/fibrinogen apheresis, with complete hearing recovery. In this patient, in addition to reducing LDL cholesterol and fibrinogen, the circulating adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1), previously present in higher than normal concentrations, were reduced by the treatment.
authors.affiliation: Section of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ramunni
authors.forename: Nicola
authors.initials: N
authors.lastname: Quaranta
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Saliani
authors.forename: Rosa Anna
authors.initials: RA
authors.lastname: Fallacara
authors.forename: Roberto
authors.initials: R
authors.lastname: Ria
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ranieri
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D015815:Cell Adhesion Molecules / Q000009:adverse effects / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D003639:Hearing Loss, Sudden / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000302:isolation & purification; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D015815:Cell Adhesion Molecules; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D005340:Fibrinogen