[Clinical efficacy and cost benefit of oral antimicrobial prophylaxis with levofloxacin on neurological surgery].
OBJECTIVE
The clinical efficacy and cost benefit of oral antimicrobial prophylaxis with levofloxacin (LVFX) on neurosurgical operation were evaluated.


METHODS
Fifty patients undergone burr hole drainage for chronic subdural hematoma were enrolled into this study. These patients had preoperative intravenous drip infusion of 1.0 g of cefazolin (CEZ), and were given oral 200 mg of LVFX twice a day for postoperative 6 days on their operations. Clinical effect on prophylaxis of postsurgical infection and surgical site infection as well as safeness of the drug were assessed. Their clinical course were retrospectively compared with another fifty patients as control group who had intravenous administration of CEZ for consecutive 7 days on same operation.


RESULTS
There were no patients who had postsurgical infection and surgical site infection as well as drug related adverse effect, whereas three patients in control group suffered urinary infections or respiratory tract infection during their postsurgical course.


CONCLUSIONS
Less invasive oral antimicrobial prophylaxis with LVFX is effective to prevent postoperative infections and surgical site infections, and attractive from the medical economic point of view.
Akiyama
Yasuhiko
Y
Department of Neurosurgery, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Simane 693-8501, Japan. yakiyama@med.shimane-u.ac.jp
Miyazaki
Takeshi
T
Daisu
Mitsuhiro
M
Yamamoto
Yoshiaki
Y
Shinguu
Takashi
T
Maruyama
Nobuyuki
N
Nagai
Hidemasa
H
Moritake
Kouzo
K
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000191:economics*; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D015242:Ofloxacin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin