Targeted-cryosurgical ablation of the prostate with androgen deprivation therapy: quality of life in high-risk prostate cancer patients.
OBJECTIVE
To present preliminary results on health-related quality of life (QoL), prostate-associated symptoms and therapeutic effects of targeted-cryosurgical ablation of the prostate (TCSAP) with androgen deprivation therapy (ADT) in high-risk prostate cancer (PCa) patients.


METHODS
Thirty-four men with high-risk PCa features underwent TCSAP, and ADT was added to improve the treatment outcomes. High-risk parameters were defined as either prostate-specific antigen (PSA) = or > 100ng/mL, or Gleason score = or > 8, or both. The Genito-Urinary Group of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) with prostate-cancer-specific module (QLQ-PR25) was used for evaluating morbidities and PSA levels were recorded every 3 months. PSA failure was defined as the inability to reach a nadir of 0.4 ng/mL or less.


RESULTS
Although it was not statistically significant, the global health status scores increased after TCSAP with ADT. The scores for five functional scales also became higher after treatment. The most prominent symptom after treatment was sexual dysfunction, followed by treatment-related and irritative voiding symptoms.


CONCLUSIONS
TCSAP with ADT appears to be minimally invasive with high QoL except for sexual dysfunction. Long-term follow-up of PSA data and survival is necessary before any conclusions can be made on the efficacy of this promising new therapeutic modality in the treatment of PCa.
Kang
Seok-Ho
SH
Department of Urology, Korea University Hospital, Seoul 136-705, Korea.
Kim
Jin-Wook
JW
Bae
Jae-Hyun
JH
Park
Hong-Seok
HS
Moon
Du-Geon
DG
Yoon
Duck-Ki
DK
Cheon
Jun
J
Kim
Je-Jong
JJ
D000368:Aged; D000369:Aged, 80 and over; D003452:Cryosurgery / Q000379:methods / Q000523:psychology; D004542:Ejaculation; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D007723:Korea; D007989:Libido; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000523:psychology; D011471:Prostatic Neoplasms / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D017430:Prostate-Specific Antigen