Piperacillin-tazobactam-induced drug hypersensitivity syndrome.
The drug hypersensitivity syndrome (DHS) is a rare but serious and potentially life-threatening reaction to common drugs in predisposed individuals. The syndrome is a triad of fever, skin eruption, and internal organ involvement. Prompt identification and discontinuation of the offending drug with symptomatic treatment of toxic effects is the mainstay of therapy for DHS.
Fahim
Simone
S
Division of Dermatology, Department of Medicine, University of Ottawa, Ontario, Canada. simonefahim@sympatico.ca
Jain
Vikas
V
Victor
Gary
G
Pierscianowski
Tadeusz
T
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000503:physiopathology*; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D010878:Piperacillin / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination
D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin