title: De novo CD5-positive diffuse large B-cell lymphoma of the temporal bone presenting with an external auditory canal tumor.
abstract: We report a 74-year-old woman with primary CD5-positive diffuse large B-cell lymphoma (DLBCL) of the temporal bone. The patient was admitted because of a mass in the left external auditory canal. She was treated with eight courses of CEOP therapy (rituximab was added from the sixth course) followed by radiotherapy of 40 Gy, and complete remission was achieved. The occurrence of malignant lymphoma in the temporal bone, which is an extremely unusual site, may have depended on the peculiarity of CD5-positive DLBCL.
authors.affiliation: Department of Hematology, Mie University Graduate School of Medicine, Edobashi, Tsu.
authors.forename: Shoko
authors.initials: S
authors.lastname: Ogawa
authors.forename: Isao
authors.initials: I
authors.lastname: Tawara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
authors.forename: Miho
authors.initials: M
authors.lastname: Kimura
authors.forename: Kana
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Motoko
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D001859:Bone Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D018956:CD5 Antigens; D003520:Cyclophosphamide / Q000008:administration & dosage; D004424:Ear Canal; D004428:Ear Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D000069283:Rituximab; D013701:Temporal Bone; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018956:CD5 Antigens; D015251:Epirubicin; D000069283:Rituximab; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone