Pharmacokinetics of amixin after repeated peroral administration to mice.
Pharmacokinetics of amixin was studied after repeated administration (5 days) to animals. Perorally administered amixin is characterized by high bioavailability and is present in the circulation in high concentrations for a long time. The main pharmacokinetic parameters were estimated by the method of linear regression because of slow elimination of amixin from organs and tissues. Our results indicate that repeated treatment with amixin holds much promise for the prevention and therapy of chronic diseases (particularly hepatitides).
Golovenko
N Ya
NY
Department of Physicochemical Pharmacology, A. V. Bogatskii Physicochemical Institute, Ukrainian Academy of Sciences, Odessa. golovenko@interchem.com.ua
Borisyuk
I Yu
IY
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D006505:Hepatitis / Q000188:drug therapy; D007700:Kinetics; D016014:Linear Models; D008297:Male; D051379:Mice; D013994:Tilorone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D013997:Time Factors; D014018:Tissue Distribution
D013994:Tilorone