title: Inhibitory activity of plant stilbene oligomers against DNA topoisomerase II.
abstract: The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in alpha-viniferin 13-O-beta-glucopryranoside (2) and hemsleyanol C (13).
authors.affiliation: Meiji Dairies Corporation, Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Ken
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Kimiko
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
mesh_terms: D000818:Animals; D016831:Crithidia fasciculata / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D010936:Plant Extracts / Q000494:pharmacology; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000037:antagonists & inhibitors*; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D015800:Protozoan Proteins; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors; C090528:DNA modification methylase HindIII; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)