The mathematical model of insulin desorption from the bioactive, fibrous artificial store.
The aim of this study was to study insulin desorption from fibrous insulin artificial store in vitro as well as in vivo, with the intention to define a mathematical model that would describe this process. Release profile of cylindrical fibrous matrixes for various insulin concentrations, desorption temperatures, time periods, and pH were presented. Change of insulin concentration in the fibers and the effect of insulin release were discussed. This model was also used to predict the optimal conditions of the release process. Possibility of predicting the effect of the fibrous store design parameters (fibre radius, amount of bonded insulin, fiber type) on the resulting insulin release rate was the major advantage of this mathematical model. Also, taking all the relevant conditions regarding these experiments into consideration, by the application of mathematical model, the diffusion coefficient during insulin release was determined.
Medovic
Adela
A
Department of Textile Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia and Montenegro. adela@infosky.net
Skundric
Petar
P
Kostic
Mirjana
M
Pajic-Lijakovic
Ivana
I
D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007474:Ion Exchange; D007700:Kinetics; D008954:Models, Biological; D012996:Solutions
D007328:Insulin; D012996:Solutions