[The effect of actovegin on spermatogenesis in white male rats upon clinical death modeling].
The indices of spermatogenesis in white male rats have been studied after clinical death modeling by means of cardiac fascicle compression. The model disorder leads to a reliable decrease in the number of spermatogenic epithelium, Sertoli cells, and Leydig cells in the testicles. A single injection of actovegin (10 mg/kg) during the reanimation period decreases the disturbances in spermatogenesis and leads to its complete recovery by the 45th day of postreanimation period.
Shevantaeva
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Kosiuga
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D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002452:Cell Count; D003128:Coma / Q000188:drug therapy*; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007985:Leydig Cells / Q000166:cytology / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000166:cytology / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*
D000975:Antioxidants; D006418:Heme; C015646:Actovegin