Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?
Hepatocyte growth factor (HGF) has emerged as a potent, endogenous antifibrotic factor that shows an impressive efficacy in ameliorating tissue fibrosis in a wide variety of animal models. Herrero-Fresneda et al. provide new evidence demonstrating that intramuscular injection of HGF gene reduces mortality, inflammation, and renal fibrosis in chronic allograft nephropathy.
Liu
Y
Y
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. liuy@upmc.edu
Yang
J
J
D000818:Animals; D005355:Fibrosis; D015316:Genetic Therapy / Q000379:methods*; D017228:Hepatocyte Growth Factor / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016030:Kidney Transplantation; D009393:Nephritis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology / Q000628:therapy
D017228:Hepatocyte Growth Factor