title: Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.
abstract: BACKGROUND
  Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines. A -463G>A polymorphism in the promoter region of the MPO gene has been shown to reduce MPO expression and activity. It is therefore possible that carriers of the -463A allele may be at decreased risk of lung cancer. To test this hypothesis we have investigated the association between the -463G>A polymorphism of MPO gene and the risk of lung cancer in a Korean population.
  
  
  METHODS
  The MPO genotype was determined in 432 lung cancer patients and 432 healthy controls that were frequency-matched for age and gender.
  
  
  RESULTS
  In the current study, the risk estimate for lung cancer of the combined -463 AA+GA genotype was not significantly different from that of the -463GG genotype (adjusted OR=1.03, 95% CI=0.72-1.47). In addition, we observed no evidence of effect modification by age, gender, smoking history or tumor histology.
  
  
  CONCLUSIONS
  These results suggest that the MPO -463G>A polymorphism does not significantly affect the susceptibility to lung cancer in Koreans.
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu 700-412, South Korea.
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Park
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Sung Ick
authors.initials: SI
authors.lastname: Cha
authors.forename: Eung Bae
authors.initials: EB
authors.lastname: Lee
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Sin
authors.initials: S
authors.lastname: Kam
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Jung
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009195:Peroxidase / Q000096:biosynthesis* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D009195:Peroxidase