title: Beneficial effects of statins on perioperative cardiovascular outcome.
abstract: OBJECTIVE
  This review evaluates clinical and experimental articles that have recently been published on the cardioprotective effect of perioperative statin therapy.
  
  
  RESULTS
  Perioperative statin therapy improves short and long-term cardiac outcome following noncardiac surgery. This cardiovascular protection has been attributed to the so-called pleiotropic effects, which have a positive effect on plaque stability. With no clinical studies reporting an increased incidence of adverse effects of perioperative statin use, it appears to be a safe and helpful therapeutic option.
  
  
  CONCLUSIONS
  Perioperative statin therapy may stabilize coronary plaques due to pleiotropic effects and results in a reduction of perioperative cardiovascular complications.
authors.affiliation: Vascular Surgery, The Netherlands.
authors.forename: Martin
authors.initials: M
authors.lastname: Dunkelgrun
authors.forename: Olaf
authors.initials: O
authors.lastname: Schouten
authors.forename: Harm Hh
authors.initials: HH
authors.lastname: Feringa
authors.forename: Radosav
authors.initials: R
authors.lastname: Vidakovic
authors.forename: Don
authors.initials: D
authors.lastname: Poldermans
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000517:prevention & control; D019990:Perioperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors