title: [The relationship between the Wnt signaling and the psychiatric diseases].
abstract: It has been demonstrated that the neuronal plasticity and resilience could participate in the pathophysiology of neurodegenerative diseases such as Alzheimer and others like depression and schizophrenia. Recently, it has been proposed a new intracellular pathway, known as Wnt pathway, which could be related to the induction of the plastic changes mentioned above. The glycogen synthase kinase-3beta (GSK-3beta), one of the main enzymes of the Wnt signaling, has been associated to Alzheimer;s and schizophrenia diseases etiology. Furthermore, the mood stabilizing agents;s action mechanism, like lithium and valproic acid, implies the inhibition of this protein. The issue of this work is to describe the proteins that are recruited when this pathway is activated and the GSK-3beta role in the pathologies mentioned.
authors.affiliation: Instituto de Investigación farmacológico, Conicet, Argentina. aferrero@ffyb.uba.ar
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ferrero
authors.forename: Marina
authors.initials: M
authors.lastname: Cereseto
authors.forename: Laura
authors.initials: L
authors.lastname: Sifonios
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000503:physiopathology*; D003863:Depression / Q000201:enzymology / Q000503:physiopathology*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D012559:Schizophrenia / Q000201:enzymology / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors; D051153:Wnt Proteins / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology
chemical_list: D014157:Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3