Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism.
We have studied the serology of 6 patients with palindromic rheumatism. None of the patients fulfilled the classification criteria for rheumatoid arthritis at the entry; however, 4 out of the 6 patients were seropositive for IgM rheumatoid factor (IgM-RF) at entry. Sequential serological study was performed in 4 patients; IgM-RF changed from seronegative to seropositive in one patient, and the titer increased in another patient. Anti-cyclic citrullinated peptide antibody (anti-CCP Ab) at the entry was detected in only one of the 6 patients; that patient later developed RA. Although follow-up is necessary, the present study may suggest the importance of serological examination, especially anti-CCP Ab, in patients with palindromic rheumatism.
Tamai
Mami
M
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Sakamoto, Nagasaki.
Kawakami
Atsushi
A
Iwanaga
Nozomi
N
Fujikawa
Keita
K
Tanaka
Fumiko
F
Aramaki
Toshiyuki
T
Izumi
Yasumori
Y
Aratake
Kouichiro
K
Arima
Kazuhiko
K
Kamachi
Makoto
M
Nakamura
Hideki
H
Huang
Mingguo
M
Ida
Hiroaki
H
Origuchi
Tomoki
T
Eguchi
Katsumi
K
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000097:blood / Q000276:immunology*; D012217:Rheumatoid Factor / Q000097:blood / Q000276:immunology*
D007075:Immunoglobulin M; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor