Experimental advances for high-speed evaluation of electron densities.
Evaluating electron densities of entire classes of chemically or biologically related compounds is within reach thanks to advances in high-speed high-resolution synchrotron diffraction: a 12 h sequence of diffraction experiments has been conducted at the beamline X10SA of the Swiss Light Source (SLS). It resulted in four high-resolution X-ray data sets used for experimental electron density determinations of the two halogenated fullerenes C60F18 and C60Cl30, the Watson and Crick base pair adenine-thymine and the tripeptide L-Ala-Gly-L-Ala. Application is considered relevant for life sciences where the study of structure-guided biological recognition processes can now be completed by electronic information of entire series of molecules.
Luger
Peter
P
Wagner
Armin
A
Hübschle
Christian B
CB
Troyanov
Sergey I
SI
D000225:Adenine / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004583:Electrons; D037741:Fullerenes / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
D037741:Fullerenes; D009842:Oligopeptides; D000225:Adenine; D013941:Thymine