Duration selectivity organization in the inferior colliculus of the big brown bat, Eptesicus fuscus.
Duration selectivity of auditory neurons plays an important role in sound recognition. Previous studies show that GABA-mediated duration selectivity of neurons in the central nucleus of the inferior colliculus (IC) of many animal species behave as band-, short-, long- and all-pass filters to sound duration. The present study examines the organization of duration selectivity of IC neurons of the big brown bat, Eptesicus fuscus, in relation to graded spatial distribution of GABA(A) receptors, which are mostly distributed in the dorsomedial region of the IC but are sparsely distributed in the ventrolateral region. Duration selectivity of IC neuron is studied before and during iontophoretic application of GABA and its antagonist, bicuculline. Bicuculline application decreases and GABA application increases duration selectivity of IC neurons. Bicuculline application produces more pronounced broadening of the duration tuning curves of neurons at upper IC than at deeper IC but the opposite is observed during GABA application. The best duration of IC neurons progressively lengthens and duration selectivity decreases with recording depth both before and during drug application. As such, low best frequency neurons at upper IC have shorter best duration and sharper duration selectivity than high best frequency neurons in the deeper IC have. These data suggest that duration selectivity of IC neurons systematically varies with GABA(A) receptor distribution gradient within the IC.
Jen
Philip H-S
PH
Division of Biological Sciences and Interdisciplinary Neuroscience Program, University of Missouri-Columbia, 65211, USA. jenp@missouri.edu
Wu
Chung Hsin
CH
D000818:Animals; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D002685:Chiroptera / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology; D007245:Inferior Colliculi / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010897:Pitch Discrimination / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013998:Time Perception / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid