title: The effects of a new amino-acid dipeptide solution on nitrogen balance and humoral growth factors in the postoperative state in man.
abstract: 27 patients admitted for elective abdominal surgery were allocated to receive postoperative total parenteral nutrition supplemented with glutamine (glycyl-glutamine) and tyrosine (glycyl-tyrosine) containing dipeptides (DP-Gln 20; 0.16 g glutamine/kg BW/24 h) or isonitrogenous Vamin 18 for 5 days. The aim was to evaluate safety and effects on short-life plasma proteins, nitrogen balance, 3-methylhistidine excretion and alimentary growth factors in plasma. No differences in transthyretin or retinol binding protein levels, nitrogen balance or 3-methylhistidine excretion were found in patients receiving DP-Gln 20 compared to Vamin 18. There were higher plasma levels of peptide YY in the dipeptide group 5 days after surgery (p < 0.05). A correlation between insulin levels and nitrogen balance was found only in DP-Gln 20 treated patients day 6 (r = 0.91, p < 0.01). DP-Gln 20 is a glutamine dipeptide (Gly-Gln) containing amino acid solution which is considered safe in the postoperative state in man. No beneficial effects on whole body protein metabolism were found by adding DP-Gln 20 to total parenteral nutrition.
authors.affiliation: Department of Surgery, University Hospital, Linköping, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Wirén
authors.forename: T E
authors.initials: TE
authors.lastname: Adrian
authors.forename: F
authors.initials: F
authors.lastname: Hammarqvist
authors.forename: K E
authors.initials: KE
authors.lastname: Johansson
authors.forename: J
authors.initials: J
authors.lastname: Permert
authors.forename: B
authors.initials: B
authors.lastname: Petersson
authors.forename: J
authors.initials: J
authors.lastname: Wernerman
authors.forename: J
authors.initials: J
authors.lastname: Larsson