title: [Ziprasidone as coadjuvant treatment in resistant obsessive-compulsive disorder treatment].
abstract: Data suggest that atypical antipsychotics may be useful in the treatment of obsessive-compulsive disorder (OCD). We report the case of a patient diagnosed of serious OCD resistant to various antidepressant and antipsychotic treatments (including clozapine). The patient had clinically significant improvement (measured by decrease in the score of the Yale-Brown Obsessive Compulsive (Y-BOCS) and the Clinical Global Impression (CGI) scales) in the four weeks alter switching from clozapine to ziprasidone, improvement that was subsequently maintained. The pharmacodynamic characteristics of ziprasidone could make this drug more effective than other antipsychotics as coadjuvant treatment in OCD
authors.affiliation: Servicio de Psiquiatría, Hospital Valle del Nalón, Asturias. icelso@yahoo.es
authors.forename: C
authors.initials: C
authors.lastname: Iglesias Garcia
authors.forename: S
authors.initials: S
authors.lastname: Santamarina Montila
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso Villa
mesh_terms: D014150:Antipsychotic Agents / Q000378:metabolism / Q000627:therapeutic use*; D003511:Cyclohexanols / Q000378:metabolism / Q000627:therapeutic use; D004351:Drug Resistance; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*; D000069470:Venlafaxine Hydrochloride
chemical_list: D014150:Antipsychotic Agents; D003511:Cyclohexanols; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone; D000069470:Venlafaxine Hydrochloride