title: Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.
abstract: The synthesis of new furo-salicylanilides and their heterocyclic derivatives is described. Twenty-three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Ghaneya Sayed
authors.initials: GS
authors.lastname: Hassan
authors.forename: Gehan Hegazy
authors.initials: GH
authors.lastname: Hegazy
authors.forename: Hany Mohamed
authors.initials: HM
authors.lastname: Safwat
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000138:chemical synthesis* / Q000633:toxicity; D015394:Molecular Structure; D008975:Molluscacides / Q000138:chemical synthesis* / Q000633:toxicity*; D009534:Niclosamide / Q000592:standards / Q000633:toxicity; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000633:toxicity; D012550:Schistosoma mansoni / Q000187:drug effects / Q000254:growth & development; D012995:Solubility; D013329:Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods
chemical_list: D005663:Furans; D008975:Molluscacides; D012458:Salicylanilides; D009534:Niclosamide