title: Histologic studies of the bypassed stomach after Roux-en-Y gastric bypass in a porcine model.
abstract: BACKGROUND
  Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is highly effective for morbid obesity. However, the long-term effects in the bypassed segments are unknown. The aim of this study is to evaluate gastrin and histologic changes in bypassed segments after LRYGBP.
  
  
  METHODS
  10 50-kg pigs were subjected to LRYGBP. Preoperative weight and serum gastrin were compared with similar measures at 6 months postoperatively, when the pigs were euthanized. At necropsy, full-thickness gastric, duodenal, and jejunal biopsies were performed. Normal biopsies were obtained from a control group of 10 pigs.
  
  
  RESULTS
  1 pig died at 3 months postoperatively because of an intestinal intussusception. In the remaining 9 pigs, weight increased after surgery from 52+/-2.2 kg to 55+/-1.9 kg. Serum gastrin was unchanged after surgery (mean 68.2 vs 68.3 pg/mL at 3 months and 61.7 pg/mL at 6 months). Histology showed no abnormalities from sections in all control pigs, and in 7 of the LRYGBP pigs as well. 1 LRYGBP pig was found to have hyperplastic duodenal glands, jejunal mucosa with mild chronic inflammation, and gastric mucosa with focal erosive gastritis. 1 LRYGBP pig had jejunal sections showing Peyer's patches.
  
  
  CONCLUSIONS
  LRYGBP is not associated with gastrin changes and major histologic changes in the bypassed segments, at 6 months postoperatively in the porcine model.
authors.affiliation: Department of Surgery, New York Presbyterian Hospital, Weill College of Medicine of Cornell University, NY 10021, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gentileschi
authors.forename: Michel
authors.initials: M
authors.lastname: Gagner
authors.forename: Luca
authors.initials: L
authors.lastname: Milone
authors.forename: Subhash
authors.initials: S
authors.lastname: Kini
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukuyama
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods; D000818:Animals; D004195:Disease Models, Animal; D015390:Gastric Bypass / Q000379:methods*; D005755:Gastrins / Q000097:blood; D011183:Postoperative Complications / Q000473:pathology; D013270:Stomach / Q000473:pathology* / Q000601:surgery; D013552:Swine
chemical_list: D005755:Gastrins