title: Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN: findings in repeat biopsies at 6 months.
abstract: OBJECTIVE
  To evaluate morphological findings in repeat biopsies in patients with isolated high-grade prostatic intraepithelial neoplasia (HGPIN) after a 6-month course of bicalutamide (Casodex) 50 mg/day.
  
  
  METHODS
  20 consecutive patients with isolated HGPIN in prostate biopsies were treated for 6 months with bicalutamide 50 mg/day. After treatment, the patients were resubmitted to prostate biopsy mapping. The control group included 22 untreated consecutive patients with isolated high-grade PIN with repeat biopsies taken 6 months after the initial biopsies.
  
  
  RESULTS
  In the initial biopsies of the treated group, HGPIN was monofocal in 12 patients and plurifocal in 8. In the repeat biopsies HGPIN was present in 2 patients, monofocal in both, whereas prostate adenocarcinoma (PCa) was discovered in one. In the control group, HGPIN was monofocal in 15 and plurifocal in 7. In the repeat biopsies HGPIN was present in six patients, being monofocal in three and plurifocal in the other three. PCa was present in one.
  
  
  CONCLUSIONS
  There was a lower incidence of HGPIN (treated group vs control: 10% vs 27.2%) after 6 months of bicalutamide. Reduction in its extent was also observed (treated group vs control: monofocal 100% vs 50%). Treatment did not affect the incidence of cancer (treated vs control: 5% vs 4.5%).
authors.affiliation: Urology Division, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
authors.forename: Aldo V
authors.initials: AV
authors.lastname: Bono
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzucchelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ferrari
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Galosi
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
mesh_terms: D000368:Aged; D000813:Anilides / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D019048:Prostatic Intraepithelial Neoplasia / Q000188:drug therapy* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide