How bacteria and their products provide clues to vaccine and adjuvant development.
Evidence has emerged that both vertebrates and invertebrates share innate immune pathways involved in the recognition of and the response to micro-organisms, including bacteria and their products. As a consequence, particular degenerate products of bacteria can stimulate and modulate immune responses and influence acquired immunity and, potentially, protection against disease. New knowledge in this field is beginning to explain how vaccine adjuvants work and will facilitate the future development of novel adjuvants and vaccines.
Dougan
Gordon
G
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. gd1@sanger.ac.uk
Hormaeche
Carlos
C
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001419:Bacteria / Q000276:immunology*; D001427:Bacterial Toxins / Q000494:pharmacology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides