Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury.
In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.
Scorpio
Diana G
DG
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, Maryland 21205, USA. dscorpio@jhmi.edu
von Loewenich
Friederike D
FD
Göbel
Heike
H
Bogdan
Christian
C
Dumler
J Stephen
JS
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D041081:Anaplasma phagocytophilum / Q000276:immunology*; D000818:Animals; D004195:Disease Models, Animal; D016873:Ehrlichiosis / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D008107:Liver Diseases / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology*; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D016513:Mice, SCID; D053594:Myeloid Differentiation Factor 88; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism; D010586:Phagocytes / Q000201:enzymology; D048069:Tumor Necrosis Factors / Q000235:genetics / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; C507779:MYD88 protein, human; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D048069:Tumor Necrosis Factors; D010088:Oxidoreductases; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse