title: Fluorescent in situ hybridization and array comparative genomic hybridization: complementary techniques for genomic evaluation.
abstract: During the past few years a new high-throughput molecular technology, array comparative genomic hybridization, has received a great deal of attention. As a DNA-based tool, this technique is presumably more reproducible than expression arrays. In this review, I discuss how array comparative genomic hybridization is remarkably similar with regard to genome analysis to fluorescent in situ hybridization, a technique that is generally regarded as one of the more accurate and reproducible molecular techniques in diagnostic surgical pathology. A thorough understanding of this technology will be useful for all surgical pathologists in the near future, as this technology will no doubt have some influence on our daily practice.
authors.affiliation: The Pathology Core Facility,Arthur James Cancer Hospital and Richard Solove Research Institute, The Ohio State University Medical School, Columbus 43210, USA. Carl.Morrison@osumc.edu
authors.forename: Carl
authors.initials: C
authors.lastname: Morrison
mesh_terms: D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010340:Pathology, Surgical / Q000379:methods* / Q000639:trends