Signaling downstream of p38 in psoriasis.
Psoriasis is an inflammatory skin disease characterized by infiltration of the skin by T cells and increased production of pro-inflammatory cytokines. Two recent reports show that the p38-activated kinases mitogen-activated protein kinase-activated protein kinase 2 and mitogen- and stress-activated protein kinase are activated in psoriatic skin and may contribute to the production of pro-inflammatory cytokines.
Arthur
J Simon C
JS
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom. j.s.c.arthur@dundee.ac.uk
Darragh
Joanne
J
D006801:Humans; D011565:Psoriasis / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
D048051:p38 Mitogen-Activated Protein Kinases