title: The dose of nafamostat mesilate during plasma exchange with continuous hemodiafiltration in the series-parallel circuit.
abstract: We studied nafamostat mesilate (NM) and interleukin (IL)-18 levels to determine whether the dose of NM is reduced during plasma exchange (PE) with continuous hemodiafiltration (CHDF) when the series-parallel circuit is used. The subjects of the current study included four patients with acute hepatic failure who underwent PE with CHDF. The four patients underwent a total 15 PE + CHDF procedures, and for each procedure, they were randomized to receive either a half-dose of NM or no NM in the CHDF circuit. Eight procedures were carried out with NM administration, and seven were carried out without NM administration. The dose of NM in the NM group was significantly higher than that in the non-NM group (P = 0.040). No significant differences were observed between the two groups in the inlet NM concentration, the outlet NM concentration, or the rate of IL-18 removal. No statistical correlation was observed between the IL-18 level and the NM dose, the inlet NM concentration, or the outlet NM concentration. There was no blood access difficulty such as catheter failure or clotting of the filter. Thus, it might be possible to carry out PE and CHDF with the series-parallel method without administration of NM in the CHDF circuit.
authors.affiliation: Department of Integrated Medicine, Division of Emergency and Critical Care Medicine, Akita University School of Medicine, Akita, Japan. nakaeh@doc.med.akita-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakae
authors.forename: Toshiko
authors.initials: T
authors.lastname: Igarashi
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Tajimi
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000097:blood / Q000494:pharmacology*; D001550:Benzamidines; D015415:Biomarkers; D004305:Dose-Response Relationship, Drug; D005260:Female; D006146:Guanidines / Q000097:blood / Q000494:pharmacology*; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D020382:Interleukin-18 / Q000097:blood* / Q000378:metabolism; D017114:Liver Failure, Acute / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods*
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D015415:Biomarkers; D006146:Guanidines; D020382:Interleukin-18; C032855:nafamostat