title: A tris(2,2'-bipyridine)ruthenium(II) derivative tethered to a cis-PtCl2(amine)2 moiety: syntheses, spectroscopic properties, and visible-light-induced scission of DNA.
abstract: A tris(2,2'-bipyridine)ruthenium(II) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(II)Pt(II) dimer having a cis-Pt(II)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(mu-bridge)PtCl2](PF6)2 (bpy = 2,2'-bipyridine, bridge = 4,4'-bis(N-(3-aminopropyl)carbamoyl)-2,2'-bipyridine). The ESI-TOF mass spectrum of the Ru(II)Pt(II) dimer shows a set of signals corresponding to {[Ru(bpy)2(mu-bridge)PtCl2](PF6)}(+) (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(II)Pt(II) dimer with either 5'-GMP (guanosine 5'-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(II)Pt(II) dimer.
authors.affiliation: Department of Chemistry, Faculty of Science, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka, 812-8581, Japan. ksakaiscc@mbox.nc.kyushu-u.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Sakai
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ozawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamada
authors.forename: Taro
authors.initials: T
authors.lastname: Tsubomura
authors.forename: Mariko
authors.initials: M
authors.lastname: Hara
authors.forename: Akon
authors.initials: A
authors.lastname: Higuchi
authors.forename: Masa-Aki
authors.initials: MA
authors.lastname: Haga
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004121:Dimethyl Sulfoxide; D007202:Indicators and Reagents; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010957:Plasmids / Q000737:chemistry; D012313:RNA / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D009942:Organometallic Compounds; C522451:bis(2,2'-bipyridine)(4,4'-bis(3-aminopropylcarbamoyl)-2,2'-bipyridine)ruthenium(II); D012313:RNA; D004247:DNA; D002945:Cisplatin; D004121:Dimethyl Sulfoxide