Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma.
BACKGROUND
Imiquimod has been successfully used for treatment of various epithelial cutaneous neoplasms.


OBJECTIVE
Our aim was to evaluate the efficacy and tolerability of imiquimod 5% cream for treatment of Bowen's disease and invasive squamous cell carcinoma (SCC) in patients who were unsuitable candidates for surgery.


METHODS
Five Bowen's disease lesions and 7 invasive SCC lesions on 10 patients were treated with imiquimod once daily 5 times a week for a maximum of 16 weeks.


RESULTS
After 8 to 12 weeks of treatment, 4 of 5 Bowen's disease lesions (80%) and 5 of 7 invasive SCCs (71.4%) showed complete clinicopathologic regression. The remaining 3 lesions showed partial regression after 16 weeks of treatment. No recurrence has been detected after a follow-up period of 24 to 38 months (mean, 31 months).


CONCLUSIONS
The study is an open-label clinical trial on a small number of selected patients, with lack of excision with serial step sections.


CONCLUSIONS
Topical application of imiquimod 5% cream might represent an alternative topical treatment to surgery in selected cases of Bowen's disease and invasive SCC.
Peris
Ketty
K
Department of Dermatology, University of L'Aquila, Italy. peris@univaq.it
Micantonio
Tamara
T
Fargnoli
Maria Concetta
MC
Lozzi
Gian Piero
GP
Chimenti
Sergio
S
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod