title: Inhibitory effects of selected antiepileptics on spontaneous motility of isolated human oviducts.
abstract: OBJECTIVE
  Spontaneous motility of the human oviduct is an important factor in the regulation of fertility that can be influenced by a variety of substances. In this study we examined the effects of several antiepileptic drugs on spontaneous contractions of isolated human oviducts.
  
  
  METHODS
  The isolated ampullar and isthmic segments of Fallopian tubes, taken from 34 patients with extensive uterine fibroids, were exposed to carbamazepine, lamotrigine, valproic acid, phenobarbital, diazepam and lorazepam.
  
  
  RESULTS
  Carbamazepine and lamotrigine produced concentration-dependent inhibition of spontaneous contractions of both ampullar and isthmic isolated preparations, while the other investigated substances did not exhibit any effect. The effective concentrations of carbamazepine and lamotrigine fall within the range of their therapeutic serum concentrations.
  
  
  CONCLUSIONS
  When choosing antiepileptics for women of reproductive age, the effects of the drug on motility of the Fallopian tubes should also be considered.
authors.affiliation: Pharmacology Department, Medical Faculty, University of Kragujevac, Ul. Svetozara Markovica 69, 34000 Kragujevac, Serbia, Yugoslavia. slobnera@EUnet.yu
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Jankovic
authors.forename: Snezana V
authors.initials: SV
authors.lastname: Jankovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Kostic
authors.forename: Irena
authors.initials: I
authors.lastname: Kostic
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Jakovljevic
mesh_terms: D000927:Anticonvulsants / Q000097:blood / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005187:Fallopian Tubes / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*
chemical_list: D000927:Anticonvulsants; D004121:Dimethyl Sulfoxide