title: An information-motivation-behavioral skills model of adherence to antiretroviral therapy.
abstract: HIV-positive persons who do not maintain consistently high levels of adherence to often complex and toxic highly active antiretroviral therapy (HAART) regimens may experience therapeutic failure and deterioration of health status and may develop multidrug-resistant HIV that can be transmitted to uninfected others. The current analysis conceptualizes social and psychological determinants of adherence to HAART among HIV-positive individuals. The authors propose an information-motivation-behavioral skills (IMB) model of HAART adherence that assumes that adherence-related information, motivation, and behavioral skills are fundamental determinants of adherence to HAART. According to the model, adherence-related information and motivation work through adherence-related behavioral skills to affect adherence to HAART. Empirical support for the IMB model of adherence is presented, and its application in adherence-promotion intervention efforts is discussed.
authors.affiliation: Department of Psychology and Center for Health/HIV Intervention and Prevention, University of Connecticut, Storrs, CT 06269-1020, USA. jeffrey.fisher@uconn.edu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Fisher
authors.forename: William A
authors.initials: WA
authors.lastname: Fisher
authors.forename: K Rivet
authors.initials: KR
authors.lastname: Amico
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Harman
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D036262:Empirical Research; D015658:HIV Infections / Q000188:drug therapy*; D015438:Health Behavior; D006801:Humans; D033181:Information Dissemination; D009042:Motivation; D010349:Patient Compliance / Q000706:statistics & numerical data*; D011584:Psychology
chemical_list: D044966:Anti-Retroviral Agents