title: The effects of a timolol maleate gel-forming solution on normotensive beagle dogs.
abstract: The effects of a timolol maleate gel-forming solution (TMGS) on intraocular pressure (IOP), blood pressure (BP), and pupil size (PS) were evaluated in normotensive dogs. TMGS was administered once daily to six normotensive beagle dogs. TMGS administration reduced IOP and PS. The hypotensive effect persisted for 24 hr after the administration. The mean reduction in IOP was 5.3 mm Hg (P<0.01). The changes in BP and PS were not significant. These results suggest that TMGS can potentially be used in the treatments of glaucoma and ocular hypertension in dogs.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Science, Nihon University, Fujisawa, and Centerville Animal Hospital, Tokyo, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Takiyama
authors.forename: Saori
authors.initials: S
authors.lastname: Shoji
authors.forename: Isao
authors.initials: I
authors.lastname: Habata
authors.forename: Sigeo
authors.initials: S
authors.lastname: Ohba
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D005260:Female; D005782:Gels / Q000737:chemistry*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*; D013999:Timolol / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D005782:Gels; D009883:Ophthalmic Solutions; D013999:Timolol