title: Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer.
abstract: OBJECTIVE
  To evaluate concentration of MMP-9 in blood plasma and broncho-alveolar lavage fluid (BALF) from patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Blood plasma from 40 NSCLC patients and 40 healthy donors was collected and concentrations of blood plasma and BALF MMP-9 were measured using ELISA. Correlation between MMP-9 level and gender, histological type of tumor and stage of disease was analyzed.
  
  
  RESULTS
  Levels of blood plasma MMP-9 were significantly higher in NSCLC patients (p < 0.0001) then in control group, and were especially high in patients with stage IV of disease (stage I vs stage IV - p < 0.005, stage II vs stage IV - p < 0.01, stage III vs stage IV - p < 0.01). Also, stage IV of NSCLC was characterized by the highest level of BALF MMP-9 (stage I vs stage IV - p < 0.002, stage II vs stage IV p < 0.002, and stage III vs stage IV p < 0.007). Correlation between blood plasma and BALF MMP-9 levels and gender or histological type of tumor was insignificant.
  
  
  CONCLUSIONS
  Our data revealed significant correlation between tumor stage and BALF and plasma MMP-9 levels in NSCLC patients.
authors.affiliation: Department of Biochemistry, Izzet Baysal School of Medicine, Abant Izzet Baysal University, Bolu, Turkey. gbugdayci@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Bugdayci
authors.forename: T
authors.initials: T
authors.lastname: Kaplan
authors.forename: S
authors.initials: S
authors.lastname: Sezer
authors.forename: T
authors.initials: T
authors.lastname: Turhan
authors.forename: Y
authors.initials: Y
authors.lastname: Koca
authors.forename: B
authors.initials: B
authors.lastname: Kocer
authors.forename: E
authors.initials: E
authors.lastname: Yildirim
mesh_terms: D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D020780:Matrix Metalloproteinase 9