title: Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond.
abstract: Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
authors.affiliation: Beckman Institute, University of Illinois at Urbana--Champaign, Urbana, Illinois 61801, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: Grossman
authors.forename: Georgina M
authors.initials: GM
authors.lastname: Aldridge
authors.forename: Ivan Jeanne
authors.initials: IJ
authors.lastname: Weiler
authors.forename: William T
authors.initials: WT
authors.lastname: Greenough
mesh_terms: D000818:Animals; D049229:Dendritic Spines / Q000502:physiology*; D005600:Fragile X Syndrome / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology*