Residue depletion of tilmicosin in cattle after subcutaneous administration.
A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneous injection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were selected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples of the injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrations were determined using a high-performance liquid chromatography (HPLC) method with a UV detector at 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Products of European Medical Evaluation Agency, the withdrawal time of 34 days was established when all tissue residues except samples in the injection site were below the accepted maximum residue limits.
Jiang
Haiyang
H
Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094, People's Republic of China.
Ding
Shuangyang
S
Li
Jiancheng
J
An
Dianjin
D
Li
Cun
C
Shen
Jianzhong
J
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D005260:Female; D007279:Injections, Subcutaneous; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D018942:Macrolides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry; D012680:Sensitivity and Specificity; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D018942:Macrolides; C052319:tilmicosin; D015645:Tylosin