title: Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins.
abstract: The formation of protein-decorated nanosized polymeric particles is described. Annexin-A5 protein binding to micellar aggregates having poly((1-ethoxycarbonyl)vinylphosphonic diacid) (PECVPD) and poly(n-butyl acrylate) (PBuA) as corona- and core-forming segments, respectively, was evidenced by Static and Dynamic Light Scattering (SDLS), cryo-Transmission Electron Microscopy (cryo-TEM), and Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments. These new objects find potential applications, for example, in micelle-mediated target drug delivery and controlled fabrication of biochips.
authors.affiliation: Laboratoire de Chimie des Polymères Organiques (LCPO), ENSCPB, Université Bordeaux 1, 16 Av. Pey Berland, 33607 Pessac Cedex, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Schmidt
authors.forename: Cristiano
authors.initials: C
authors.lastname: Giacomelli
authors.forename: François
authors.initials: F
authors.lastname: Lecolley
authors.forename: Joséphine
authors.initials: J
authors.lastname: Lai-Kee-Him
authors.forename: Alain R
authors.initials: AR
authors.lastname: Brisson
authors.forename: Redouane
authors.initials: R
authors.lastname: Borsali
mesh_terms: D017304:Annexin A5 / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D017304:Annexin A5; D008823:Micelles