title: Antioxidant properties of methanolic extracts from leaves of Rhazya stricta.
abstract: Because of increased safety concerns about synthetic antioxidants, exploitation of cheaper and safer sources of antioxidants based on natural origin is the focus of research nowadays. Rhazya stricta is a medicinally important plant native to South Asia. Extraction of antioxidants was carried out in different solvent systems, i.e., water, 80% methanol, 70% ethanol, and diethyl ether. The methanolic extract exhibited the highest total phenolic content among the extracts; therefore for further studies the methanolic extract was employed. Antioxidant activity measurement in the linoleic acid system, metal chelating activity, reducing power, scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical, and superoxide anion radical scavenging activity were taken as the parameters for assessment of antioxidant potential of methanolic extracts. Results were compared with alpha-tocopherol and the synthetic antioxidant butylated hydroxyanisole. The antioxidant potential of methanolic extracts of R. stricta leaves was comparable with previously exploited potent antioxidants and is strongly concentration dependent.
authors.affiliation: Departments of Chemistry , University of Sargodha, Sargodha, Pakistan. ranashahid313@gmail.com
authors.forename: Shahid
authors.initials: S
authors.lastname: Iqbal
authors.forename: M I
authors.initials: MI
authors.lastname: Bhanger
authors.forename: Mubeena
authors.initials: M
authors.lastname: Akhtar
authors.forename: Farooq
authors.initials: F
authors.lastname: Anwar
authors.forename: Khawaja Raees
authors.initials: KR
authors.lastname: Ahmed
authors.forename: Tabraz
authors.initials: T
authors.lastname: Anwer
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D001713:Biphenyl Compounds; D002083:Butylated Hydroxyanisole / Q000737:chemistry; D002614:Chelating Agents; D016166:Free Radical Scavengers / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D019787:Linoleic Acid / Q000737:chemistry; D000432:Methanol; D010084:Oxidation-Reduction; D010636:Phenols / Q000032:analysis; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D016166:Free Radical Scavengers; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; D002083:Butylated Hydroxyanisole; D019787:Linoleic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; D024502:alpha-Tocopherol; D000432:Methanol