Transmission of hepatitis C virus between parents and children.
Egyptian children with infected parents are at high risk of infection with hepatitis C (HCV). Analysis of data collected during surveys of rural communities show children whose parents had antibodies to HCV (anti-HCV) were at higher risk for having anti-HCV than children whose parents did not. The association was greater with mothers than fathers and when the parent had HCV RNA. For instance, 87 (14%) of 612 children had anti-HCV whose mothers had HCV RNA compared with 28 (7%) of 401 whose mothers only had anti-HCV and 79 (2.6%) of 3,086 whose mothers were seronegative. These associations persisted after controlling for age, parenteral exposures, and serologic status of the other parent. Sequencing isolates from 13 families with parent(s) and children having HCV RNA showed 10 of 18 had genetically similar viruses. These findings suggest Egyptian children are at high risk of being infected with HCV by their parents and identification of the transmission routes would allow for preventive measures.
Mohamed
Mostafa K
MK
National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt. ecgc@internetegypt.com
Magder
Laurence S
LS
Abdel-Hamid
Mohamed
M
El-Daly
May
M
Mikhail
Nabiel N
NN
Abdel-Aziz
Fatma
F
Medhat
Ahmed
A
Thiers
Valerie
V
Strickland
G Thomas
GT
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D016015:Logistic Models; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires
D018937:Hepatitis C Antibodies; D012367:RNA, Viral