Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.
BACKGROUND
Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines. A -463G>A polymorphism in the promoter region of the MPO gene has been shown to reduce MPO expression and activity. It is therefore possible that carriers of the -463A allele may be at decreased risk of lung cancer. To test this hypothesis we have investigated the association between the -463G>A polymorphism of MPO gene and the risk of lung cancer in a Korean population.


METHODS
The MPO genotype was determined in 432 lung cancer patients and 432 healthy controls that were frequency-matched for age and gender.


RESULTS
In the current study, the risk estimate for lung cancer of the combined -463 AA+GA genotype was not significantly different from that of the -463GG genotype (adjusted OR=1.03, 95% CI=0.72-1.47). In addition, we observed no evidence of effect modification by age, gender, smoking history or tumor histology.


CONCLUSIONS
These results suggest that the MPO -463G>A polymorphism does not significantly affect the susceptibility to lung cancer in Koreans.
Park
Jae Hyung
JH
Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu 700-412, South Korea.
Park
Jung Min
JM
Kim
Eun Jin
EJ
Cha
Sung Ick
SI
Lee
Eung Bae
EB
Kim
Chang Ho
CH
Kam
Sin
S
Jung
Tae Hoon
TH
Park
Jae Yong
JY
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009195:Peroxidase / Q000096:biosynthesis* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
D009195:Peroxidase