Inflammatory degeneration of joint tissue in adjuvant arthritis after intraarticular treatment with the mixture of silver drug and nicotinic acid.
Combination intraarticular administration of Poviargol (0.5 mg/kg) and nicotinic acid (1.0 mg/kg) reduced symptoms of local and general inflammation in rats with adjuvant arthritis. We revealed a decrease in morphological signs of inflammatory degeneration of joint tissue and reduction of metabolic disorders.
Mitrofanov
V A
VA
Saratov Research Institute of Traumatology and Orthopedics, Russian Public Health Agency. sarniito@yandex.ru
Ovchinnikova
N M
NM
Belova
S V
SV
Fedotova
M V
MV
Gladkova
E V
EV
D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology*; D004357:Drug Synergism; D005434:Flow Cytometry; D006025:Glycosaminoglycans / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy*; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009525:Niacin / Q000008:administration & dosage*; D051381:Rats; D018030:Silver Compounds / Q000008:administration & dosage*; D013583:Synovial Membrane / Q000473:pathology; D014574:Uronic Acids / Q000378:metabolism; D014665:Vasodilator Agents / Q000008:administration & dosage
D006025:Glycosaminoglycans; D018030:Silver Compounds; D014574:Uronic Acids; D014665:Vasodilator Agents; C081379:poviargol; D009525:Niacin