title: Experimental wound healing using microamperage electrical stimulation in rabbits.
abstract: We investigated the effects of microamperage electrical stimulation (MES) on the healing of skin incision in rabbits. Thirty male adult rabbits were randomly divided into sham-treated and experimental groups. Each group was divided into three subgroups, based on the duration of experiment (4, 7, and 15 days). A full-thickness incision was made on the skin of each rabbit. The experimental group received an MES of 200 microamperes current intensity for 2 h/day. Morphometrical and biomechanical evaluations were carried out. The mean number of fibroblasts at day 7 and the mean of tensile strength at day 15 were found to be significantly higher for the experimental group than for those in the sham-treated group (p < 0.01 and p < 0.05, respectively). Daily application of MES significantly accelerated the wound-healing process of full-thickness incision in the rabbits' skin.
authors.affiliation: Cell and Molecular Biology Research Center and Department of Anatomy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. bayat_m@yahoo.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bayat
authors.forename: Zahra
authors.initials: Z
authors.lastname: Asgari-Moghadam
authors.forename: Mohammad
authors.initials: M
authors.lastname: Maroufi
authors.forename: Fatemeh-Sadat
authors.initials: FS
authors.lastname: Rezaie
authors.forename: Maryam
authors.initials: M
authors.lastname: Bayat
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rakhshan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D007150:Immunohistochemistry; D008297:Male; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D013718:Tensile Strength; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*