title: Current and new strategies for the delivery of antiseptic agents.
abstract: The present mini-review explores the current methods used for the delivery of antiseptics and topical antimicrobials. Relevance of hand scrub with antiseptic liquid soap (e.g. chlorhexidine, PVP-iodine, triclosan) and alcohol-based hand rub is discussed and compared in terms of bactericidal activity, skin tolerance, and medical staff observance. New strategies for antibacterial delivery focus on the challenge of colloidal drug carrier such as liposomes, micro- and nanoparticles enabling sustained bactericidal effect and effective bacterial targeting.
authors.affiliation: Pharmacie, Hôpital Debrousse, Hospices Civils de Lyon, 29, rue Saeur Bouvier F-69322 Lyon Cedex 05 - France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Constant
authors.forename: Françoise
authors.initials: F
authors.lastname: Falson
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pirot
mesh_terms: D019840:2-Propanol / Q000008:administration & dosage / Q000627:therapeutic use; D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012867:Skin / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure
chemical_list: D000891:Anti-Infective Agents, Local; D019840:2-Propanol