Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea.
To evaluate the prevalence and risk factors of Clonorchis sinensis infection, an epidemiologic survey was performed (3,169 residents; age range: 30-87 years; mean age = 59; 1,973 women) in three areas with different mortality rates of cholangiocarcinoma. C. sinensis prevalence was 2.1% in Chuncheon, 7.8% in Chungju, and 31.3% in Haman, where cholangiocarcinoma incidence rate was 0.3, 1.8, and 5.5 per 100,000 persons, respectively. Of the four major risk factors for C. sinensis (male sex, alcohol consumption, raw freshwater fish intake, and area of residence), area was the strongest. Efforts to discourage raw freshwater fish intake, treat egg carriers, and protect water sources from C. sinensis contamination should be strengthened in the Republic of Korea.
Lim
Min Kyung
MK
Research Institute for National Cancer Control and Evaluation, National Cancer Center, Goyang, Gyeonggi, Republic of Korea.
Ju
Young-Hee
YH
Franceschi
Silvia
S
Oh
Jin-Kyoung
JK
Kong
Hyun-Joo
HJ
Hwang
Seung-Sik
SS
Park
Sue-Kyung
SK
Cho
Sung-Il
SI
Sohn
Woon-Mok
WM
Kim
Dong-Il
DI
Yoo
Keun-Young
KY
Hong
Sung-Tae
ST
Shin
Hai-Rim
HR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D000818:Animals; D001650:Bile Duct Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000469:parasitology; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000453:epidemiology* / Q000401:mortality / Q000469:parasitology; D003003:Clonorchiasis / Q000150:complications / Q000453:epidemiology*; D003004:Clonorchis sinensis; D005243:Feces / Q000469:parasitology; D005260:Female; D005399:Fishes; D005843:Geography; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors