title: Air pollution and very low birth weight infants: a target population?
abstract: OBJECTIVE
  The goal was to examine systematically the association between maternal exposure to particulate matter of <10 microm and very low birth weight (<1500 g) delivery for evidence of an effect on duration of gestation and/or intrauterine growth restriction.
  
  
  METHODS
  This case-control study took place between April 1, 1986, and March 30, 1988, in Georgia Health Care District 9 and included 128 mothers of very low birth weight infants, all of whom were preterm and were classified as either small for gestational age or appropriate for gestational age, and 197 mothers of term, appropriate-for-gestational-age infants weighing > or = 2500 g. Maternal exposure to particulate matter of <10 microm was estimated with 2 exposure measures, namely, a county-level measure based on residence in a county with an industrial point source and an environmental transport model based on the geographic location of the birth home.
  
  
  RESULTS
  Considering preterm/appropriate-for-gestational-age infants as cases and term/appropriate-for-gestational-age infants as controls, adjusted odds ratios for maternal exposure to particulate matter of <10 microm were statistically significant (adjusted odds ratio for county-level model: 4.31; adjusted odds ratio for environmental transport model: 3.68). Although elevated, no statistically significant association was found between maternal exposure and preterm/appropriate-for-gestational-age delivery when compared to preterm/small-for-gestational-age delivery.
  
  
  CONCLUSIONS
  There are increased odds of maternal exposure to ambient particulate matter of <10 microm for very low birth weight preterm/appropriate-for-gestational-age delivery, compared with term/appropriate-for-gestational-age delivery, which suggests that the observed association between maternal exposure to air pollution and low infant birth weight (particularly <1500 g) is at least partially attributable to an effect on duration of gestation.
authors.affiliation: National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: J Felix
authors.initials: JF
authors.lastname: Rogers
authors.forename: Anne L
authors.initials: AL
authors.lastname: Dunlop
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D018811:Maternal Exposure; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D012621:Seasons
chemical_list: D000393:Air Pollutants