title: Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
abstract: The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of FcRn in the epithelium is shown here to be associated with secretion of IgG into the lumen that allows for defense against an epithelium-associated pathogen (Citrobacter rodentium). This pathway of host resistance to a bacterial pathogen as mediated by FcRn involves retrieval of bacterial antigens from the lumen and initiation of adaptive immune responses in regional lymphoid structures. Epithelial-associated FcRn, through its ability to secrete and absorb IgG, may thus integrate luminal antigen encounters with systemic immune compartments and as such provide essential host defense and immunoregulatory functions at the mucosal surfaces.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Masaru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kanna
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Kuo
authors.forename: Lynn
authors.initials: L
authors.lastname: Bry
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Glickman
authors.forename: Steven M
authors.initials: SM
authors.lastname: Claypool
authors.forename: Arthur
authors.initials: A
authors.lastname: Kaser
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaishi
authors.forename: Darren E
authors.initials: DE
authors.lastname: Higgins
authors.forename: Emiko
authors.initials: E
authors.lastname: Mizoguchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Wakatsuki
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Wayne I
authors.initials: WI
authors.lastname: Lencer
authors.forename: Richard S
authors.initials: RS
authors.lastname: Blumberg
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D018928:Immunity, Mucosal; D007074:Immunoglobulin G / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016133:Polymerase Chain Reaction; D011961:Receptors, Fc / Q000235:genetics / Q000502:physiology*; D017452:Receptors, IgG / Q000235:genetics / Q000502:physiology*
chemical_list: C485701:Fcgr1 protein, mouse; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG