title: Estimation of bulky lymph nodes by power Doppler ultrasound scanning in patients with Hodgkin's lymphoma: a prospective study.
abstract: The accuracy of standard methods in estimating bulky lesions requires validation. We used clinical/computed tomography (CT) evaluation and power Doppler ultrasound (US) to detect bulky disease in 137 consecutive Hodgkin's lymphoma patients, and analyzed the prognostic relevance of each method. Bulky disease was detected by clinical/CT evaluation in 47% of the patients and by power Doppler US in 20%. After treatment, at multivariate analysis power Doppler US-selected bulky disease was the parameter that best correlated with freedom from treatment failure (p<0.001). Power Doppler US, a readily available imaging technique, provides a better prognostic classification by detecting true bulky disease more accurately.
authors.affiliation: Department of Biochemistry and Medical Biotechnology, Federico II University Medical School, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Picardi
authors.forename: Rosanna
authors.initials: R
authors.lastname: Ciancia
authors.forename: Amalia
authors.initials: A
authors.lastname: De Renzo
authors.forename: Barbara
authors.initials: B
authors.lastname: Montante
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Pio
authors.initials: P
authors.lastname: Zeppa
authors.forename: Roberto
authors.initials: R
authors.lastname: Lobello
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pane
authors.forename: Diego
authors.initials: D
authors.lastname: D'Agostino
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicolai
authors.forename: Cesare
authors.initials: C
authors.lastname: Sirignano
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Bruno
authors.initials: B
authors.lastname: Rotoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003951:Diagnostic Errors; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000592:standards; D018608:Ultrasonography, Doppler / Q000379:methods* / Q000592:standards