title: The Generation R Study: Design and cohort profile.
abstract: The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioral and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. Data collection in the prenatal phase included physical examinations, questionnaires, fetal ultrasound examinations and biological samples. In addition, more detailed assessments are conducted in a subgroup of 1232 pregnant women and their children. The children form a prenatally recruited birth-cohort that will be followed until young adulthood. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
authors.affiliation: The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.forename: Johan P
authors.initials: JP
authors.lastname: Mackenbach
authors.forename: Henriëtte A
authors.initials: HA
authors.lastname: Moll
authors.forename: Eric A P
authors.initials: EA
authors.lastname: Steegers
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.forename: Frank C
authors.initials: FC
authors.lastname: Verhulst
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D005191:Family Characteristics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010290:Parents; D011247:Pregnancy; D015995:Prevalence