title: Evaluation of periapical repair following retrograde filling with different root-end filling materials in dog teeth with periapical lesions.
abstract: OBJECTIVE
  The objective of this study was to evaluate periapical repair following retrograde filling using different root-end filling materials.
  
  
  METHODS
  After induction of periapical lesions, 48 root canals from dog teeth were partially filled. Endodontic surgery was performed and 3 different materials were used for root-end filling: Sealer 26, Sealapex plus zinc oxide, or mineral trioxide aggregate (MTA). No additional procedures were performed in the control group after partial filling of the root canal. After 180 days, the animals were killed, the maxillas and mandibles were removed, and specimens were submitted for histologic processing.
  
  
  RESULTS
  Histopathologic analysis revealed similar periapical repair for the groups in which Sealer 26, Sealapex plus zinc oxide, and MTA were used (P > .05). The control group showed unsatisfactory periapical repair (P < .05).
  
  
  CONCLUSIONS
  There was no difference in periapical tissue healing after retrograde filling with the tested materials, which indicates that these 3 root-end filling materials are equally useful.
authors.affiliation: Department of Endodontics, Araraquara School of Dentistry, State University of São Paulo-UNESP, Brazil.
authors.forename: Mário
authors.initials: M
authors.lastname: Tanomaru-Filho
authors.forename: Marcone R
authors.initials: MR
authors.lastname: Luis
authors.forename: Mario R
authors.initials: MR
authors.lastname: Leonardo
authors.forename: Juliane M G
authors.initials: JM
authors.lastname: Tanomaru
authors.forename: Léa A B
authors.initials: LA
authors.lastname: Silva
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D001729:Bismuth / Q000494:pharmacology; D017610:Calcium Compounds / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000494:pharmacology; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D008297:Male; D010087:Oxides / Q000494:pharmacology; D010485:Periapical Periodontitis / Q000628:therapy*; D012184:Retrograde Obturation / Q000379:methods*; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D012459:Salicylates / Q000494:pharmacology; D017640:Silicates / Q000494:pharmacology; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D012459:Salicylates; C080620:Sealer 26; D017640:Silicates; C086631:mineral trioxide aggregate; C055601:Sealapex; D002126:Calcium Hydroxide; D001729:Bismuth