Clopidogrel-associated acute migratory arthritis following kidney-pancreas transplantation.
Clopidogrel is a potent inhibitor of platelet aggregation and has been used as an alternative, or as an adjunct to aspirin in reducing the risk of thrombosis. A 34-year-old uremic type 1 male diabetic patient who underwent simultaneous kidney-pancreas transplantation was given clopidogrel as he was allergic to aspirin. He developed polyarthralgia one week later, followed in a few days by symmetrical migratory polyarthritis, which resolved completely on withdrawing the drug. The implications to clinical management in a transplant setting are discussed.
Muthusamy
A S R
AS
Oxford Transplant Centre, Churchill Hospital, Headington, Oxford, United Kingdom. anandsivaprakash@hotmail.com
Vaidya
A
A
Friend
P J
PJ
D000328:Adult; D001168:Arthritis / Q000139:chemically induced*; D000077144:Clopidogrel; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000139:chemically induced*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014511:Uremia / Q000150:complications
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine