Short report: role of type I/II scavenger receptors in malarial infection in C57BL/6J mice.
Although it is well known that SR-A I/II plays a significant role in host defense against bacterial and viral infection, the contribution of SR-A I/II to protozoan infection is not well understood. Thus, we examined the possible role of SR-A I/II against murine malarial infection, such as Plasmodium. berghei and P. yoelli, by using SR-A I/II knockout mice with a C57BL/6J genetic background. When SR-A I/II knockout mice were infected with P. berghei NK65 or P. yoelli 17X, their survival rates were not significantly different from wild-type animals. In terms of the kinetics of parasitemia, hematocrit values and the number of white blood cells, there were no significant differences between the genotypes in P. berghei NK65 or P. yoelli 17X infection. Taken together with the findings in our previous report, the SR-A I/II functional contribution to host defense in malarial infection does not seem to be widely extended, and the effect of SR-A I/II seem in collaboration with other, as yet unidentified, gene(s).
Inoue
Mai
M
Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Xuan
Xuenan
X
Fujisaki
Kozo
K
Igarashi
Ikuo
I
Suzuki
Hiroshi
H
D000818:Animals; D001772:Blood Cell Count; D017931:DNA Primers / Q000737:chemistry; D005838:Genotype; D006400:Hematocrit; D008288:Malaria / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018512:Parasitemia / Q000097:blood; D010962:Plasmodium berghei; D010967:Plasmodium yoelii; D016133:Polymerase Chain Reaction / Q000379:methods; D051117:Scavenger Receptors, Class A / Q000276:immunology / Q000502:physiology*; D016019:Survival Analysis
D017931:DNA Primers; D051117:Scavenger Receptors, Class A