[Studying the effect of the new beta-adrenoreceptor blocker proxodolol on the ischemic model of cardiac insufficiency].
The effects of proxodolol--new beta-blocker with alpha-blocking activity--on system hemodynamics, heart function and morphology of rats with ischemia-induced congestive heart failure were studied and compared with those of carvedilol. It was shown that both drugs administered during 3 weeks after ligation of coronary artery inhibit heart remodeling and development of myocardial hypertrophy. Proxodolol was more effective than carvedilol in prevention of heart dysfunctions typical for congestive heart failure, that was especially evident during the pharmacological overload tests.
Shashurin
D A
DA
Medvedev
O S
OS
Iuzhakov
S D
SD
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000818:Animals; D002227:Carbazoles / Q000008:administration & dosage; D002303:Cardiac Output, Low / Q000188:drug therapy*; D006332:Cardiomegaly / Q000517:prevention & control*; D000077261:Carvedilol; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D010069:Oxadiazoles / Q000008:administration & dosage*; D011412:Propanolamines / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D010069:Oxadiazoles; D011412:Propanolamines; D000077261:Carvedilol; C088649:proxodolol