[Development of invasive urinary bladder carcinomas].
In this paper, we report on invasive urinary bladder carcinomas as follows, (1) p53 mutations have an important role in promotion and progression stages of carcinogenesis, (2) invasive bladder carcinomas occur multi-centrically in the bladder, (3) an organic arsenic, dimethylarsinic acid exerts carcinogenicity in the bladder of rats, (4) p53 mutations in carcinomas are caused by different carcinogens, and (5) bladder urothelium of people living in 137Cs-contaminated areas of Ukraine showed chronic proliferative atypical cystitis (so-called Chernobyl cystitis).
Fukushima
Shoji
S
The First Department of Pathology, Osaka City University Medical School.
Wanibuchi
Hideki
H
Wei
Min
M
Morimura
Keiichirou
K
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D047852:Chernobyl Nuclear Accident; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D014455:Ukraine; D001743:Urinary Bladder / Q000528:radiation effects*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology
D016159:Tumor Suppressor Protein p53; D002085:Butylhydroxybutylnitrosamine