title: Simplified ultrasound screening for fetal brain function based on behavioral pattern.
abstract: Despite the longstanding conclusion that behavior can reveal aspects of underlying anatomy and function, no generalized antenatal behavior screening has been developed to identify fetuses that may have central nervous system defects requiring further evaluation. We devised a brief ultrasound examination to distinguish fetuses with compromised central nervous system function from the general population and evaluated it with this study. The study design compared behavioral findings obtained by retrospectively reviewing the ultrasound examinations of 5 fetuses that had abnormal behavior with prospectively obtained findings of 29 normal fetuses. Median time for brief examination criteria was 50 min (range, 30-60 min). The only case undetectable by this brief ultrasound examination has an eye-movement period significantly longer than the normal upper limit. Using this method as a screening test may make it possible to include assessment of fetal brain function as part of routine antenatal care.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. morokuma@med.kyushu-u.ac.jp
authors.forename: Seiichi
authors.initials: S
authors.lastname: Morokuma
authors.forename: Kotaro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yumoto
authors.forename: Mio
authors.initials: M
authors.lastname: Uchimura
authors.forename: Arisa
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Megumi
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Satoh
authors.forename: Hitoo
authors.initials: H
authors.lastname: Nakano
mesh_terms: D002490:Central Nervous System / Q000002:abnormalities*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005324:Fetal Movement / Q000502:physiology*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal / Q000379:methods*