title: Lymphocytic-plasmacytic thyroiditis and glomerulonephritis in a boxer.
abstract: An 18-month-old boxer was presented for investigation of profound lethargy, and primary hypothyroidism was diagnosed. A strong antithyroglobulin antibody titre was also present, indicating lymphocytic (immune-mediated) thyroiditis as the cause of hypothyroidism. A concurrent protein-losing glomerulonephropathy was also detected, although the aetiology could not be determined at initial presentation. Thyroid replacement and dietary therapy were prescribed. The dog improved clinically for approximately 12 months when it was re-presented with poorly controlled hypothyroidism and renal failure. Postmortem examination confirmed the presence of lymphocytic-plasmacytic thyroiditis, in conjunction with membranoproliferative glomerulonephritis and renal failure.
authors.affiliation: Department of Small Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Belfield, Ireland.
authors.forename: C S
authors.initials: CS
authors.lastname: Mansfield
authors.forename: C T
authors.initials: CT
authors.lastname: Mooney
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D003933:Diagnosis; D018753:Diet, Protein-Restricted / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D004285:Dogs; D017809:Fatal Outcome; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D053609:Lethargy; D008297:Male; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D001323:Autoantibodies; D016226:Phosphorus, Dietary; C006606:anti-thyroglobulin; D013954:Thyroglobulin; D013974:Thyroxine