[Present insights in the cerebral small vessel disease physiopathology: the role of C-reactive protein].
The mechanisms underlying the pathogenesis of cerebral small vessel disease (SVD) are incompletely understood, although it represents a large burden upon healthcare and social service. New experimental and clinical data suggest that inflammatory reactions may play a crucial role in both the initiation and progression of SVD. Inflammatory processes could be involved in the pathogenesis of SVD, and particularly in the development of white matter lesions and leukoaraiosis. These new data regarding the possible effects of inflammatory reactions in SVD may be of more than just academic interest. It may be that adding evaluation of inflammatory markers, such as C-reactive protein, to conventional risk factors will allow more appropriate preventive and therapeutic interventions.
Di Napoli
Mario
M
Servizio di Neurologia, Ospedale Generale Provinciale San Camillo de' Lellis, Rieti. mariodinapoli@katamail.com
Papa
Francesca
F
D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood; D008833:Microcirculation; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D002097:C-Reactive Protein