Studies of interactions between uracil-based hybrid molecules and P-glycoprotein--search for multidrug resistance modulators.
The hybrid molecules having structural features of anticancer drug, 5-fluorouracil, and MDR modulator, propafenone, have been studied for their interactions with P-glycoprotein (P-gp). Some of the molecules (5, 8, and 9) show considerable interactions with P-gp and could be the potential candidates for their in vivo evaluation as MDR modulators. Further investigations show the dependence of P-gp interacting properties of these compounds on their physico-chemical parameters like logP and total polar surface area.
Singh
Palwinder
P
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. palwinder_singh_2000@yahoo.com
Paul
Kamaldeep
K
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D011485:Protein Binding; D014498:Uracil / Q000737:chemistry*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014498:Uracil