title: Concentration and daily excretion of uranium in urine of Japanese.
abstract: A study was undertaken to investigate uranium concentrations in urine samples for unexposed Japanese individuals and to evaluate uranium daily excretion. Uranium concentrations were measured with inductively coupled plasma mass spectrometry after microwave-assisted digestion and online separation using the UTEVA extraction chromatographic resin. The concentrations ranged from 0.8 to 35.6 ng of uranium per liter of urine (median 4.5 ng L(-1)). Urinary uranium was normalized relative to the creatinine concentration in order to compensate for the degree of urine dilution. Creatinine-normalized values ranged from 1.2 to 17.8 ng of uranium per gram of creatinine (median 7.4 ng g(-1) creatinine). These results corresponded to the lower end of urinary uranium reported for unexposed populations. The level of daily excreted uranium was calculated as 6.45 ng d(-1) (median value) using ICRP recommended values for 24-h creatinine excretion. These data along with literature data on uranium dietary intake for Japanese populations were used to estimate the uranium gastrointestinal absorption fraction (f(1)). The median f(1) value was calculated to be 0.007. Statistical analysis was done to investigate statistical differences and relationships between the studied variables.
authors.affiliation: Internal Dosimetry Laboratory, Department of Health Physics, Japan Atomic Energy Research Institute, Shirakata, Tokai-mura, Ibaraki-ken. tolmachv@nirs.go.jp
authors.forename: Sergei
authors.initials: S
authors.lastname: Tolmachev
authors.forename: Jun
authors.initials: J
authors.lastname: Kuwabara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D003198:Computer Simulation; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014501:Uranium / Q000652:urine*
chemical_list: D014501:Uranium