[Effect of multi-glycosides of tripterygii on latent autoimmune diabetes in adults in early stage].
OBJECTIVE
To observe the effect of multi-glycosides of tripterygii (MT) on latent autoimmune diabetes of adults (LADA) in early stage.


METHODS
The diabetic patients were divided randomly into the control group treated with insulin alone and the treated group treated with insulin and MT. Levels of insulin, C-peptide, glutamic acid decarboxylase antibody (GADAb) and islet cell antibody (ICA) were detected and clinical features of the disease were observed.


RESULTS
There was no difference between the control group and the treated group in body mass index (BMI), the occurrence of diabetic keto-acidosis and the function of liver and kidney (P >0.05). After 6 months' treatment, the positive rate of GADAb and ICA decreased, plasma levels of fasting and 2 hrs post-prandial C-peptide and also 2 hrs post-prandial true insulin in the treated group increased (P <0.01), while all the above indexes improved more significantly after 1 year's treatment (P <0.01).


CONCLUSIONS
Compared treatment of insulin with multi-glycosides of tripterygii in early stage of LADA has better effects in relieving autoimmune injury and recovering function of pancreatic island than insulin alone.
Lei
Tao
T
Department of Endocrinology, Tongji Hospital Affiliated to Tongji University, Shanghai. leitao5899@126.com
Zhang
Xiu-zhen
XZ
He
Ming
M
D000328:Adult; D017668:Age of Onset; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000145:classification / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D013997:Time Factors; D029757:Tripterygium / Q000737:chemistry*
D001323:Autoantibodies; D006027:Glycosides; D007166:Immunosuppressive Agents; D007328:Insulin