title: Synthesis and evaluation of some 1,2,3,4-tetrahydropyrimidine-2-thione and condensed pyrimidine derivatives as potential antihypertensive agents.
abstract: Some new tetrahydropyrimidine-2-thione, octahydroquinazoline-2-thione and thiazolo[3,2-a]pyrimidine derivatives have been synthesized and tested for their antihypertensive activity. Among them, compounds 1 and 2b can be considered more potent than the reference, nifedipine (CAS 21829-25-4), while compounds 3b and 10a are equipotent to it. In addition, compound 6 showed significant antihypertensive activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. magda_f_ismail@yahoo.com
authors.forename: Magda M F
authors.initials: MM
authors.lastname: Ismail
authors.forename: Nehad A M
authors.initials: NA
authors.lastname: El-Sayed
authors.forename: Heba S
authors.initials: HS
authors.lastname: Rateb
authors.forename: Mohey
authors.initials: M
authors.lastname: Ellithey
authors.forename: Yousry A
authors.initials: YA
authors.lastname: Ammar
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D007202:Indicators and Reagents; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C512629:1,2,3,4-tetrahydropyrimidine-2-thione; D000959:Antihypertensive Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D003900:Desoxycorticosterone