title: Kynurenic acid in human saliva--does it influence oral microflora?
abstract: Kynurenic acid (KYNA) is an endogenous antagonist of alpha7 nicotinic receptors and all ionotropic glutamate receptors. Its neuroprotective activity has been suggested. In this study, the presence of KYNAin human saliva and its potential bactericidal role was investigated. KYNAwas found in all samples of human saliva with mean concentration of 3.4 nM. The concentration of KYNA in saliva obtained from patients with odontogenic abscesses was 3.5 times higher than in healthy subjects. We have shown that the human gingival fibroblasts produce KYNAand an inflammatory stimulant, lipopolysaccharide, enhanced its synthesis in vitro. The bactericidal effect of KYNA was also presented. We hypothesize that KYNA may contribute to the control of oral microflora.
authors.affiliation: Department of Clinical and Experimental Pharmacology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Kuc
authors.forename: Mansur
authors.initials: M
authors.lastname: Rahnama
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tomaszewski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rzeski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wejksza
authors.forename: Teresa
authors.initials: T
authors.lastname: Urbanik-Sypniewska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Parada-Turska
authors.forename: Marian
authors.initials: M
authors.lastname: Wielosz
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Turski
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005881:Gingiva / Q000166:cytology; D006801:Humans; D007736:Kynurenic Acid / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D009055:Mouth / Q000382:microbiology*; D012463:Saliva / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D007736:Kynurenic Acid