Optical measurements during experimental stereotactic radiofrequency lesioning.
The aim of this study was to evaluate in vivo a laser Doppler measurement system in porcine brain tissue during thermal lesioning. A 2-mm monopolar radiofrequency lesioning electrode was equipped with optical fibers in order to monitor the lesioning procedure. Laser Doppler and backscattered light intensity signals were measured along the electrode trajectory and during bilateral lesioning in the central gray (70, 80 and 90 degrees C, n = 14). The time course of the coagulation process could be followed by optical recordings. Two separate groups of tissue were identified from the intensity signals. The changes in the perfusion levels in both groups displayed significant changes (p < 0.05, n = 48) at all temperature settings, while backscattered light intensity was significant for only one group at the different temperatures (p < 0.05, n = 39). These results indicate that optical measurements correlate with lesion development in vivo. The study also indicates that it is possible to follow the lesioning process intra-operatively.
Antonsson
Johan
J
Department of Biomedical Engineering, Linkoping University, Linkoping, Sweden. johan@imt.liu.se
Eriksson
Ola
O
Lundberg
Peter
P
Wårdell
Karin
K
D000818:Animals; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D023421:Models, Animal; D016343:Monitoring, Intraoperative; D016634:Radiosurgery / Q000379:methods*; D013552:Swine; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*