title: Proteoliposome derived cochleate as novel adjuvant.
abstract: Cochleate structures (CS) consist in a highly stable lipid structures that have been reported to be a good antigen delivery system. The incorporation of pathogen associated molecular pattern (PAMP) from bacterial membranes into CS became in a promising approach to develop adjuvants, particularly mucosal adjuvants. Therefore, we prepare CS from proteoliposome (PL) obtained from Neisseria meningitidis B (PLCS) and evaluated it for its capability to stimulate the immune system as well as the adjuvant activity. The ability of PLCS to induce Thl polarization was also explored. The results and the easy capability for new antigen incorporation on CS support its use as adjuvant for immunization with a large variety of pathogen derived antigens and different routes of immunization.
authors.affiliation: Immunology Department, Finlay Institute, P.O. Box 16017, Havana, Cuba. gbracho@finlay.edu.cu
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bracho
authors.forename: Miriam
authors.initials: M
authors.lastname: Lastre
authors.forename: Judith
authors.initials: J
authors.lastname: del Campo
authors.forename: Caridad
authors.initials: C
authors.lastname: Zayas
authors.forename: Domingo
authors.initials: D
authors.lastname: González
authors.forename: Danay
authors.initials: D
authors.lastname: Gil
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Acevedo
authors.forename: Carlos
authors.initials: C
authors.lastname: Taboada
authors.forename: Rosa L
authors.initials: RL
authors.lastname: Solís
authors.forename: Oliver
authors.initials: O
authors.lastname: Pérez
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009345:Neisseria meningitidis / Q000737:chemistry / Q000276:immunology; D011510:Proteolipids / Q000737:chemistry / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D011510:Proteolipids; C020485:proteoliposomes