High serum urate in HIV-infected persons: the choice of the antiretroviral drug matters.
Data with regard to serum uric acid levels in HIV-infected subjects are scarce. A high prevalence of hyperuricaemia was identified in a prospective analysis of urate levels in 2287 visits made by a cohort of 270 HIV-positive patients. In univariate and multivariate analysis, hyperuricaemia was associated with factors previously identified in HIV-uninfected individuals, but also with the use of some antiretroviral drugs, particularly with the use of stavudine.
Walker
Ulrich A
UA
Department of Clinical Immunology, Medizinische Universitätsklinik, Freiburg, Germany.
Hoffmann
Christian
C
Enters
Mark
M
Thoden
Jan
J
Behrens
Georg
G
Mitzel
Sophie L
SL
D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D033461:Hyperuricemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D018119:Stavudine / Q000009:adverse effects; D014527:Uric Acid / Q000097:blood
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D014527:Uric Acid; D018119:Stavudine