Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum.
The secretory pathway in the malaria parasite Plasmodium falciparum has many unique aspects in terms of protein destinations and trafficking mechanisms. Recently, several exciting insights into protein trafficking within this intracellular parasite have been unveiled: these include signals that are required for targeting of proteins to the red blood cell and the relict plastid (known as the apicoplast); and the elucidation of the pathways of the haemoglobin proteases targeted to the food vacuole. Protein-targeting to the apical organelles in P. falciparum, however, is still not very well understood, but available research offers a tantalising glimpse of the system.
Tonkin
Christopher J
CJ
The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Australia.
Pearce
J Andrew
JA
McFadden
Geoffrey I
GI
Cowman
Alan F
AF
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D010963:Plasmodium falciparum / Q000378:metabolism*; D021381:Protein Transport; D015800:Protozoan Proteins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism
D015800:Protozoan Proteins