An in situ approach for nickel-catalyzed cycloaddition.
A convenient method for preparing pyridines from air-stable, commercially available catalyst precursors is described. The addition of n-BuLi to Ni(acac)2 and an NHC salt (such as IPr.HCl or SIPr.HCl) rapidly generates an active Ni0/NHC catalyst for the cycloaddition of diynes and nitriles that affords pyridines without a decrease in observed yields. The in situ method also converts diynes and carbon dioxide to the corresponding pyrones.
Tekavec
Thomas N
TN
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
Zuo
Gang
G
Simon
Kristina
K
Louie
Janis
J
D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D053280:Diynes / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*
D053280:Diynes; D011725:Pyridines; D011753:Pyrones; D002245:Carbon Dioxide; D009532:Nickel