title: A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.
abstract: [Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
authors.affiliation: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., Suite 205, East Leigh Street, Richmond, Virginia 23219, USA. zlu@rdg.boehringer-ingelheim.com
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Wenyi
authors.initials: W
authors.lastname: Zhao
authors.forename: Han-Xun
authors.initials: HX
authors.lastname: Wei
authors.forename: Marine
authors.initials: M
authors.lastname: Dufour
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D007211:Indoles; D010165:Palladium