The advantage of allocating kidneys from old cadaveric donors to old recipients: a single-center experience.
BACKGROUND
In January 1999 a new kidney allocation program was launched by the Eurotransplant Foundation, the 'Eurotransplant Senior Program' (ESP). Cadaveric donors above the age of 65 yr are allocated to kidney transplant recipients of the same age group.


METHODS
Using a single-center database, 91 patients who underwent first renal transplantation at the age of 65 yr and older in the years 1999-2002 were identified. Fifty-six patients were transplanted through ESP allocation (study group) and 35 patients (control group) via normal Eurotransplant Kidney Allocation System (ETKAS) procedure.


RESULTS
Age, sex and comorbid conditions did not differ by group. The rate of acute rejection episodes, primary non-function, delayed graft function, perioperative mortality did not differ by group. Serum creatinine was significantly lower in the ETKAS group (1.3 vs. 1.9 mg/dL; p=0.015) from six months after the transplantation on. Overall graft survival at six yr was 56% in the ETKAS group and 52% in the ESP group. With 73% in the ETKAS group and 71% in the ESP group, cumulative patient survival according to the Kaplan-Meier estimation was not statistically different at five yr.


CONCLUSIONS
We did not find a relevant difference in the outcome between young and old kidney transplants in old recipients after this long observation period.
Bodingbauer
M
M
Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria. martin.bodingbauer@meduniwien.ac.at
Pakrah
B
B
Steininger
R
R
Berlakovich
G
G
Rockenschaub
S
S
Wekerle
T
T
Muehlbacher
F
F
D000368:Aged; D001706:Biopsy; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000473:pathology / Q000502:physiology*; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome