title: Proteliposome-derived Cochleate as an immunomodulator for nasal vaccine.
abstract: Proteoliposome (PL) has been recently used as a protective intramuscular (i.m.) anti-meningococcal BC vaccine. It induces a preferential Th 1 type of immune response. Nevertheless, mucosal protection is mainly mediated by IgA antibody response, which is not usually induced by i.m. vaccination route. IgA antibody production needs the stimulation of Th3 subpopulation, which is also related to the induction of small dose tolerance. We hypothesized that PL-derived Cochleate can induce a specific mucosal IgA and systemic IgG antibody responses. We could show that mice immunized with two or three intranasal doses of PL-derived Cochleate developed significantly increased levels of local anti PL IgA and systemic IgG antibody responses. Thus, our results suggest that PL-derived Cochleate can be used as a promising immunomodulator and delivery system for the development of mucosal, particularly nasal vaccines.
authors.affiliation: Immunology Department, Finlay Institute, P.O. Box 16017, Havana, Cuba. oliverp@finlay.edu.cu
authors.forename: Oliver
authors.initials: O
authors.lastname: Pérez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bracho
authors.forename: Miriam
authors.initials: M
authors.lastname: Lastre
authors.forename: Caridad
authors.initials: C
authors.lastname: Zayas
authors.forename: Domingo
authors.initials: D
authors.lastname: González
authors.forename: Danay
authors.initials: D
authors.lastname: Gil
authors.forename: Judith
authors.initials: J
authors.lastname: del Campo
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Acevedo
authors.forename: Carlos
authors.initials: C
authors.lastname: Taboada
authors.forename: Tamara
authors.initials: T
authors.lastname: Rodríguez
authors.forename: María E
authors.initials: ME
authors.lastname: Fajardo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Sierra
authors.forename: Concepción
authors.initials: C
authors.lastname: Campa
authors.forename: Nestor
authors.initials: N
authors.lastname: Mora
authors.forename: Ramón
authors.initials: R
authors.lastname: Barberá
authors.forename: Rosa L
authors.initials: RL
authors.lastname: Solís
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000281:Administration, Intranasal; D000818:Animals; D016503:Drug Delivery Systems; D018928:Immunity, Mucosal; D051379:Mice; D008807:Mice, Inbred BALB C; D011510:Proteolipids / Q000008:administration & dosage / Q000494:pharmacology*; D014612:Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D011510:Proteolipids; D014612:Vaccines; C020485:proteoliposomes