pH-induced intracellular protein transport.
A new mechanism of selective transport and localization of proteins inside any living cell is presented. The mechanism is based on pH-induced protein trapping. It is shown that spontaneous and unique spatial redistribution of different proteins is possible in any aqueous solution with stable non-uniform distribution of H(+) ions. This phenomenon was observed in artificial systems with fixed non-uniform pH distribution and in living cells.
Baskin
E M
EM
Technion-Israel Institute of Technology, Solid State Institute, 32000 Haifa, Israel.
Bukshpan
S
S
Zilberstein
G V
GV
D000818:Animals; D003720:Densitometry; D005782:Gels; D049452:Green Fluorescent Proteins; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D010798:Phycocyanin / Q000737:chemistry / Q000378:metabolism; D040081:Protein Array Analysis; D021381:Protein Transport
D005782:Gels; D009211:Myoglobin; D010798:Phycocyanin; D049452:Green Fluorescent Proteins; D009113:Muramidase