Multiple doses of cefodizime are necessary for the treatment of Neisseria gonorrhoeae pharyngeal infection.
A single dose of cefodizime (CDZM), ceftriaxone (CTRX), or spectinomycin (SPCM) is recommended for the treatment of gonococcal urethritis or uterine cervicitis in the era of multidrug-resistant Neisseria gonorrhoeae; namely, cefozopran-resistant N. gonorrhoeae (CZRNG). N. gonorrhoeae pharyngeal infection is not so rare in Japan; however, the proper treatment regimen for this infection is not clear. We previously found that a single dose of CDZM completely eradicated multidrug-resistant N. gonorrhoeae in patients with urethritis and uterine cervicitis, so we tried a single 1.0-g dose of CDZM for the treatment of N. gonorrhoeae pharyngeal infection, including infections with CZRNG. The eradication rate of N. gonorrhoeae from the pharynx was 63.0% with a single 1.0-g dose of CDZM, while the rate for CZRNG with the same dose of CDZM was 38.5%. N. gonorrhoeae was completely eradicated from the pharynx when patients received one or two additional doses of CDZM. Therefore, we concluded that two to three doses of CDZM were necessary for the treatment of N. gonorrhoeae pharyngeal infection including infection with CZRNG.
Matsumoto
Tetsuro
T
Department of Urology, School of Medicine, University of Occupational and Environmental Health Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. t-matsu@med.uoeh-u.ac.jp
Muratani
Tetsuro
T
Takahashi
Koichi
K
Ikuyama
Toshihiro
T
Yokoo
Daisuke
D
Ando
Yukiko
Y
Sato
Yumiko
Y
Kurashima
Motoko
M
Shimokawa
Hiroshi
H
Yanai
Shigeaki
S
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004351:Drug Resistance; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification*; D010608:Pharyngeal Diseases / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D002439:Cefotaxime; C033356:cefodizime