Effects of Saccharomyces boulardii on intestinal mucosa.
Saccharomyces boulardii (S. boulardii) is a non-pathogenic biotherapeutic agent, widely prescribed in a lyophilized form in many countries over the world. S. boulardii acts as a shuttle liberating effective enzymes, proteins and trophic factors during its intestinal transit that improve host immune defenses, digestion, and absorption of nutrients. In addition, S. boulardii secretes during its intestinal transit polyamines, mainly spermine and spermidine that regulate gene expression and protein synthesis. In this review, we will focus on the interactions of the yeast with the host intestinal mucosa.
Buts
Jean-Paul
JP
Laboratory of Pediatric Gastroenterology and Nutrition, Unit of Pediatric Research, Université Catholique de Louvain, Louvain, Belgium. buts@gype.ucl.ac.be
De Keyser
Nadine
N
D000818:Animals; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy; D007413:Intestinal Mucosa / Q000378:metabolism / Q000382:microbiology* / Q000648:ultrastructure; D007421:Intestine, Small / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008871:Microvilli / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure; D011073:Polyamines / Q000378:metabolism; D019936:Probiotics / Q000494:pharmacology*; D012440:Saccharomyces
D011073:Polyamines