title: Interstitial lung diseases associated with amyopathic dermatomyositis.
abstract: The aim of the present study was to clarify the clinical characteristics and prognosis of patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM). The study consisted of 14 consecutive patients with ILD-ADM. Patients were classified into two categories, acute/subacute and chronic forms, according to the clinical presentation of ILD. The clinical features, responsiveness to therapy, and prognosis between the two forms were compared. Nine ILD-ADM patients were categorised as the acute/subacute form, and five as the chronic form. Arterial oxygen tension was significantly lower in the acute/subacute ILD than chronic ILD patients. On high-resolution computed tomography, ground-glass opacities were frequently found in the two forms, but consolidation was more common in acute/subacute ILD than chronic ILD. Bronchoalveolar lavage analysis showed higher numbers of total cells and lymphocytes in acute/subacute ILD than chronic ILD. Histologically, the most common finding was nonspecific interstitial pneumonia in the two forms, while diffuse alveolar damage was only found in acute/subacute ILD. Acute/subacute ILD was generally resistant to therapy, while chronic ILD responded well. Notably, the mortality of acute/subacute ILD was much higher than that of chronic ILD (67 versus 0%, respectively). In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses.
authors.affiliation: Second Division, Dept of Internal Medicine, and 2 Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. suda@hama-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: N
authors.initials: N
authors.lastname: Enomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: D
authors.initials: D
authors.lastname: Hashimoto
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Toyoshima
authors.forename: H
authors.initials: H
authors.lastname: Hashizume
authors.forename: K
authors.initials: K
authors.lastname: Chida
mesh_terms: D000208:Acute Disease; D000368:Aged; D002908:Chronic Disease; D003882:Dermatomyositis / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography