CE-based analysis of hemoglobin and its applications in clinical analysis.
This review focuses on the developments and trends in CE including CIEF, CZE, MEKC, two-dimensional conjunction of CIEF-capillary gel electrophoresis, and MEKC-CZE on microfluidic devices coupled to different detection approaches, such as UV absorbance, LIF, MS, and chemiluminescence etc. for performing analysis of hemoglobin (Hb), also with an emphasis on its applications in clinical analysis. Analysis of human Hb is of important clinical sense for numerous hemoglobinopathies associated with the congenital defects and abnormal contents of Hb. The diversiform modes render CE a comprehensive primary clinical tool for Hb analysis, which is rapid, sensitive, high-resolution, and not labor-intensive.
Wang
Junhua
J
Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
Zhou
Shilai
S
Huang
Weihua
W
Liu
Yanming
Y
Cheng
Cheng
C
Lu
Xin
X
Cheng
Jieke
J
D019075:Electrophoresis, Capillary / Q000379:methods*; D006453:Hemoglobinopathies / Q000175:diagnosis; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D010449:Peptide Mapping; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D006454:Hemoglobins