title: Effect of peripheral vasoconstriction on pulse oximetry.
abstract: OBJECTIVE
  We tested the hypothesis that peripheral vasodilation has an effect on arterial oxygen saturation measurements by pulse oximetry, independent of temperature.
  
  
  METHODS
  Study 1 compared finger arterial oxygen saturation values (SpO(2)), before and after peripheral vasoconstriction while temperature was kept constant. This was achieved by administering dexmedetomidine (peripheral vasoconstrictor) to 16 volunteers given general anesthesia. Study 2 compared SpO(2) before and after peripheral vasodilation (brachial plexus block) in a neurally denervated left hand and a neurally innervated right hand in ten awake volunteers. In both studies measurements were also made of finger blood volume (an indicator of vasoconstriction) by photoplethysmographic determination of light transmission through a finger (LTF), finger temperature and of hemodynamic variables.
  
  
  RESULTS
  In Study 1, systolic blood pressure, SpO(2) and LTF values increased (vasoconstriction) during dexmedetomidine infusion, (P<0.0001 for all) while there were no changes in finger temperature. In Study 2, in the left hand (axillary block), temperature increased by 1.9 +/- 1.6 degrees C (P=0.004), SpO(2) decreased by 2.5 +/- 1.0 % (P<0.0001) and LTF values decreased (vasodilation) by 42 +/- 8 % (P<0.0001) after axillary block. Simultaneously, the axillary block did not induce any changes in temperature, SpO(2) or LTF values in the neurally innervated right hand.
  
  
  CONCLUSIONS
  Our results demonstrate that finger pulse oximeter SpO(2) measurements can be affected by peripheral vascular tone independent of temperature. The mechanism for this effect remains speculative and unproven.
authors.affiliation: Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143-0648, USA. talkep@anesthesia.ucsf.edu
authors.forename: Pekka
authors.initials: P
authors.lastname: Talke
authors.forename: Claudia
authors.initials: C
authors.lastname: Stapelfeldt
mesh_terms: D000328:Adult; D001831:Body Temperature; D005260:Female; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology
chemical_list: D010100:Oxygen