Apoptotic death of human lympholeukemia HL-60 cells resultant from combined effect of cobalt octa-4,5-carboxyphthalocyanine propylenglycol ether and ascorbate.
Cobalt octa-4,5-carboxyphthalocyanine propylenglycol ether proposed for antitumor therapy potentiates the cytotoxic effect of ascorbate on HL-60 human leukemia cells. Combination of these substances caused the formation of H2O2 in the medium and initiated apoptotic death of cells. Catalase abolished the cytotoxic effect of this combination. The results indicate that binary catalytic system of this combination can be regarded as a potential antitumor agent.
Akatov
V S
VS
Tissue Engineering Group, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino. v-akatoff@rambler.ru
Medvedev
A I
AI
Solov'eva
M E
ME
Merkushina
A I
AI
Leshchenko
V V
VV
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001205:Ascorbic Acid / Q000494:pharmacology*; D016923:Cell Death; D004247:DNA / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D007700:Kinetics; D009942:Organometallic Compounds / Q000494:pharmacology*; D013997:Time Factors
D000970:Antineoplastic Agents; D007211:Indoles; D009942:Organometallic Compounds; C052178:cobalt tetracarboxyphthalocyanine; D004247:DNA; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid