Changes of serum cytokine profiles in Korean vivax malarial patients after chemotherapy.
Changes of serum cytokines including interferon gamma inducible protein-10 (IP-10) chemokine were analyzed in a total of eight vivax malarial patients before and after chemotherapy by immunostaining for human cytokine antibodies attached to membranes. IP-10 was strongly reactive in the period before chloroquine/primaquine combined chemotherapy and disappeared after chemotherapy in all patients. Therefore, IP-10 chemokine may be of importance in the pathogenesis of vivax malaria and a good marker of a complete cure.
Kim
T S
TS
Department of Tropical and Endemic Parasitic Diseases, National Institute of Health, Seoul, 122-701, South Korea.
Chung
Y B
YB
Choi
H J
HJ
Yang
H J
HJ
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007378:Interleukins / Q000097:blood; D007723:Korea; D020738:Leptin / Q000097:blood; D016780:Malaria, Vivax / Q000097:blood* / Q000188:drug therapy; D010966:Plasmodium vivax
D000962:Antimalarials; D016207:Cytokines; D007378:Interleukins; D020738:Leptin