title: Myocardial systolic strain abnormalities in patients with acromegaly: a prospective color Doppler imaging study.
abstract: BACKGROUND
  Heart abnormalities are frequent findings in patients with acromegaly: systolic abnormalities are considered to be secondary to diastolic changes.
  
  
  OBJECTIVE
  The aim of the study was to evaluate whether early systolic abnormalities might be revealed in acromegalic patients using the high sensitive color Doppler myocardial imaging (CDMI) technique.
  
  
  METHODS
  Twenty-two consecutive acromegalic patients with active untreated disease (ACROUNTR) were evaluated at baseline and after a 6-month course with SS analogs (SSa) (ACROSSa); 25 healthy subjects served as controls. All subjects underwent conventional 2D-color Doppler echocardiography, pulse wave tissue Doppler imaging (PW-TDI) and CDMI.
  
  
  RESULTS
  Mean left ventricular (LV) ejection fraction did not differ in ACROUNTR and in controls; at variance, ACROUNTR patients had reduced mean LV diastolic function (E/A ratio: 0.96+/-0.3 vs controls: 1.6+/-0.3; p<0.002). Impairment of global LV diastolic function was confirmed by PW-TDI in ACROUNTR patients having a normal systolic function. Regional myocardial systolic strain (epsilon) and strain rate (SR) values, indices of regional systolic heart deformation, were lower in ACROUNTR [epsilonsys (S) -19.8+/-2.9 and epsilonsys (L): -17.7+/-2.2] than in controls [epsilonsys (S): -27.9+/-3.8; p<0.001 and epsilonsys (L): -25.3+/-2.6; p<0.001]. In addition, the early phase of diastolic function, evaluated using SR parameters, was impaired in acromegalic patients (p<0.005 vs controls). Strain and SR values were related to serum GH and IGF-I levels (p<0.02) and greatly improved after a 6-month course with SSa [epsilonsys (S) improved to -23.8+/-3.8 (p<0.05) and epsilonsys (L) improved to -24.7+/-2.4 (p<0.03)].
  
  
  CONCLUSIONS
  Our study confirms that ACROUNTR patients have impaired diastolic function. More important, our study clearly shows that ACROUNTR patients have an impairment of regional myocardial systolic function, which is not secondary to diastolic changes. These intramyocardial functional abnormalities improved during medical treatment of acromegaly. It is conceivable that GH-IGF-I excess has detrimental effects either on the diastolic or the systolic phases of heart function.
authors.affiliation: Cardiac and Thoracic Department, University of Pisa, 56124 Pisa, Italy. vdibello@med.unipi.it
authors.forename: V
authors.initials: V
authors.lastname: Di Bello
authors.forename: F
authors.initials: F
authors.lastname: Bogazzi
authors.forename: A
authors.initials: A
authors.lastname: Di Cori
authors.forename: C
authors.initials: C
authors.lastname: Palagi
authors.forename: M G
authors.initials: MG
authors.lastname: Delle Donne
authors.forename: S
authors.initials: S
authors.lastname: Gavioli
authors.forename: E
authors.initials: E
authors.lastname: Talini
authors.forename: C
authors.initials: C
authors.lastname: Cosci
authors.forename: C
authors.initials: C
authors.lastname: Sardella
authors.forename: G
authors.initials: G
authors.lastname: Tonti
authors.forename: E
authors.initials: E
authors.lastname: Martino
authors.forename: A
authors.initials: A
authors.lastname: Balbarini
authors.forename: M
authors.initials: M
authors.lastname: Mariani
mesh_terms: D000172:Acromegaly / Q000188:drug therapy / Q000503:physiopathology*; D000328:Adult; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D013599:Systole / Q000502:physiology*
chemical_list: D013004:Somatostatin