title: Neurologic toxicity associated with interferon alpha therapy for renal cell carcinoma.
abstract: A 67-year-old man received interferon alpha (IFN alpha) therapy for lung metastases of renal cell carcinoma (RCC). Multiple pulmonary metastases disappeared completely. However, neurological toxicity was detected by magnetic resonance imaging (MRI) as abnormal brain lesions. After discontinuation of IFN alpha therapy, his neurological symptoms and abnormal lesions on MRI disappeared completely. Complete remission of RCC has continued, and results of neurological study have remained normal for 5 years after discontinuation of IFN alpha therapy.
authors.affiliation: Department Of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. yoshiwad@kaiju.medic.kumamoto-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Uyama
authors.forename: Juro
authors.initials: J
authors.lastname: Nakanishi
authors.forename: Wataru
authors.initials: W
authors.lastname: Takahashi
authors.forename: Jiro
authors.initials: J
authors.lastname: Honda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kikukawa
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Jinnouchi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ueda
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D012074:Remission Induction
chemical_list: D016898:Interferon-alpha