title: New alkaloids from Phoebe grandis (Nees) Merr.
abstract: The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 microg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.
authors.affiliation: Chemistry Department, University Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Jalifah
authors.initials: J
authors.lastname: Latip
authors.forename: Noor Rain
authors.initials: NR
authors.lastname: Abdullah
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000254:growth & development; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000470:Alkaloids; D000962:Antimalarials