Synthesis and evaluation of some 1,2,3,4-tetrahydropyrimidine-2-thione and condensed pyrimidine derivatives as potential antihypertensive agents.
Some new tetrahydropyrimidine-2-thione, octahydroquinazoline-2-thione and thiazolo[3,2-a]pyrimidine derivatives have been synthesized and tested for their antihypertensive activity. Among them, compounds 1 and 2b can be considered more potent than the reference, nifedipine (CAS 21829-25-4), while compounds 3b and 10a are equipotent to it. In addition, compound 6 showed significant antihypertensive activity.
Ismail
Magda M F
MM
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. magda_f_ismail@yahoo.com
El-Sayed
Nehad A M
NA
Rateb
Heba S
HS
Ellithey
Mohey
M
Ammar
Yousry A
YA
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D007202:Indicators and Reagents; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
C512629:1,2,3,4-tetrahydropyrimidine-2-thione; D000959:Antihypertensive Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D003900:Desoxycorticosterone