Heterotrimeric G protein signaling: Getting inside the cell.
Heterotrimeric G proteins have traditionally been thought to transduce signals at the plasma membrane. In this issue, Slessareva et al. (2006) now show that a G protein alpha subunit acts at the endosome to stimulate a phosphatidylinositol 3-kinase to help yeast respond to mating pheromones.
Koelle
Michael R
MR
Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA. michael.koelle@yale.edu
D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D012100:Reproduction, Asexual / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012724:Sex Attractants / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D020962:Heterotrimeric GTP-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D012724:Sex Attractants