title: [Histiocytic sarcoma in the Swiss population of Bernese mountain dogs: a retrospective study of its genetic predisposition].
abstract: A retrospective study to evaluate the genetic predisposition for histiocytic sarcoma in the Swiss population of purebred Bernese mountain dogs identified 51 histologically confirmed cases between 1997 and 2003. Segregation analysis using five major genetic modes was used to evaluate the 51 cases. The general mode yielded the best results suggesting a genetic predisposition for histiocystic sarcoma in this breed. The disease was found in all families analyzed, therefore elimination of the disease through seletive breeding of certain family lines is not possible.
authors.affiliation: Abteilung für Bildgebende Diagnostik und Radio-Onkologie der Universität Zürich.
authors.forename: E
authors.initials: E
authors.lastname: Voegeli
authors.forename: M
authors.initials: M
authors.lastname: Welle
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: G
authors.initials: G
authors.lastname: Dolf
authors.forename: M
authors.initials: M
authors.lastname: Flückiger
mesh_terms: D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D054747:Histiocytic Sarcoma / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010375:Pedigree; D012189:Retrospective Studies; D012509:Sarcoma / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D013557:Switzerland