Neurologic manifestations in Sagliker syndrome: uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic renal failure patients.
Patients with chronic renal failure (CRF) often have signs and symptoms related to fluid and electrolyte disturbances, anemia, malnutrition, bone disease, and gastrointestinal problems. Vascular and neurologic impairment in particular remain an important source of morbidity and mortality in this vulnerable patient population. Sagliker syndrome is a novel syndrome that was recently described in 2004 in patients with CRF and severe and late secondary hyperparathyroidism who suffered from severe skull and facial bone changes, particularly from uglifying human face appearances and neuropsychiatric disorders. The goal of this study was to assess neuropsychiatric manifestations occurring in CRF patients with Sagliker syndrome. Four female and 8 male patients with CRF on regular dialysis at the hemodialysis units of the Internal Medicine Departments around southern Turkey participated in the study. All patients underwent a clinical neurologic examination performed by the same neurologist. Neuropsychiatric signs and symptoms were found in all cases. The results showed that the most frequent neurologic manifestations in CRF patients with Sagliker syndrome were headache, polyneuropathy, cranial neuropathy, fatigue, and psychiatric disorders.
Giray
Semih
S
Baskent University Adana Teaching and Research Hospital Neurology Department, Adana, Turkey.
Sagliker
Yahya
Y
Yildiz
Ismail
I
Halvaci
Ilker
I
Paylar
Nuray
N
Ocal
Fatih
F
Balal
Mustafa
M
Ozkaynak
Piril Sagliker
PS
Paydas
Saime
S
Sagliker
Cemal
C
Sagliker
Hasan Sabit
HS
Kiralp
Necati
N
Adam
Siddik Momin
SM
Esenturk
Mustafa
M
Gocmez
Erdal
E
Taskapan
Hulya
H
Yuksekgonul
Musa
M
Emir
Idris
I
Guler
Turgay
T
Yakar
Hasan
H
Sekin
Oktay
O
Kayali
Erkan
E
Caliskan
Sihli
S
Eskiocak
Ali Fuat
AF
Ogruk
Bulent
B
Guzelyurt
Tamer
T
Kurt
Cemal
C
D000293:Adolescent; D000328:Adult; D001847:Bone Diseases / Q000150:complications*; D003389:Cranial Nerve Diseases / Q000453:epidemiology; D005147:Facial Bones; D005221:Fatigue; D005260:Female; D006261:Headache / Q000453:epidemiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011115:Polyneuropathies / Q000453:epidemiology; D006435:Renal Dialysis; D013577:Syndrome