Compliance with routine antenatal rhesus D prophylaxis and the impact on sensitisations: observations over 14 years.
Documented routine antenatal anti-D prophylaxis was given to 90% and 81-87% of eligible women at 28 and 34 weeks of gestation, respectively, during the early 1990s and early 2000s. With increasing experience and education, a significant improvement in the timing of the first (OR 0.26, 95% CI 0.16-0.41: P < 0.0001) and second injections (OR 0.40, 95% CI 0.26-0.61: P < 0.0001) occurred during the latter period. Despite these improvements, there was no reduction in the sensitisation rate at 0.4%. However, this low rate occurred despite significant proportions of women delivering more than 42 days after the second injection. Fifteen of the 16 sensitised women had received routine antenatal prophylaxis.
MacKenzie
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IZ
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK. ray.anson@obs.ac.uk
Findlay
J
J
Thompson
K
K
Roseman
F
F
D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007114:Immunization / Q000592:standards*; D007267:Injections; D011181:Postnatal Care / Q000592:standards; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011295:Prenatal Care / Q000592:standards*; D012203:Rh Isoimmunization / Q000517:prevention & control*; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage*; D016312:Treatment Refusal
D018029:Rho(D) Immune Globulin