title: [Application of metabonomics in complicated theory system research of traditional Chinese medicine].
abstract: Metabonomics, a new and rapid-developing technology, will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine (TCM). Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system, promote the quantitative and scientific elucidation of TCM syndrome differentiation, provide an in-depth understanding of the TCM theory of Zang-xiang, help predict the disease on-set, and achieve a comprehensive evaluation of systemic clinical efficacy, safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal microflora ecology. The new approach with combined metabonomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.
authors.affiliation: Shanghai Institute for System Biology, Shanghai Jiao Tong University, China. weijia@sjtu.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Jiang
authors.forename: Min-jun
authors.initials: MJ
authors.lastname: Chen
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhao
authors.forename: Ming-mei
authors.initials: MM
authors.lastname: Zhou
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Yang
authors.forename: Mi-qu
authors.initials: MQ
authors.lastname: Wang
authors.forename: Ming-feng
authors.initials: MF
authors.lastname: Qiu
authors.forename: Yong-yu
authors.initials: YY
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D003937:Diagnosis, Differential; D006706:Homeostasis; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods; D008660:Metabolism
chemical_list: D015415:Biomarkers