title: New frontiers in the therapeutic management of transplant rejection.
abstract: Understanding of the mechanisms of transplant and xenotransplant rejection represents one of the most important aspects of both basic and clinical immunology. This review discusses the roles of 1) immune response and 2) the influence of various products of arachidonic acid metabolism on immune response in graft survival. The review also includes an overview of novel therapeutic approaches developed to prevent, or at least delay, graft rejection. New discoveries in basic and clinical immunology have generated new areas of research in pharmacology that may prevent rejection more efficiently, a key issue in modern medicine.
authors.affiliation: FOCIS Centers of Excellence, Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas. sanctisj@ucv.ve
authors.forename: Juan B
authors.initials: JB
authors.lastname: De Sanctis
authors.forename: Jenny V
authors.initials: JV
authors.lastname: Garmendia
authors.forename: Anna
authors.initials: A
authors.lastname: Radzioch
authors.forename: Danuta
authors.initials: D
authors.lastname: Radzioch
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D016718:Arachidonic Acid