[Review of bioactivities of natural cycloartane triterpenoids].
Cycloartane triterpenoids, which exist widely in nature, are mainly distributed in Astragalus (Leguminosae) species, Trib. Cimicifuga (Ranunculaceae) and Thalictrium (Ranunculaceae) species and possess various bioactivities. Along with the development of isolation techniques of phytochemistry, more and more this kind of compounds are isolated and identified. However, bioactivity researches on the compounds are relatively lagged behind. Most researches are still in screening level, deficient in mechanism elucidation, short of action proven in vivo and SAR analysis. The author summarized the bioactivity of this kind of compounds from all aspects: anti-tumor, anti-virus, antibacterial, anti-inflammation, immune-regulatory, cardiovascular system, hepatic protection and so forth. This will be benefit for the further research and development of the compounds.
Tian
Ze
Z
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Xiao
Pei-gen
PG
Wen
Jie
J
Huang
Feng
F
Yang
Meng-su
MS
Chen
Shi-lin
SL
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D027883:Astragalus Plant / Q000737:chemistry; D031885:Cimicifuga / Q000737:chemistry; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D031949:Thalictrum / Q000737:chemistry; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C085352:cycloartane