Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate.
This study was designed to determine the effect of ornithine alpha-ketoisocaproate (O-KIC), a compound reducing muscle protein breakdown in physiological conditions, on liver factors involved in drug metabolism in rats with acute retrograde pyelonephritis. 91 rats were assigned to 7 groups differing in the level of food intake, induced infection, and the treatment by O-KIC (168 mg/kg bw/day). Rats were killed on the third day. O-KIC increased nitrogen balance and weight gain in controls, but not in malnourished infected or non-infected rats. Liver glutathione was significantly reduced by O-KIC in malnourished infected and non-infected rats. Though O-KIC induced a rise in liver microsomal proteins in control and infected animals, it decreased cytochrome P-450 in controls, and aminopyrine demethylase in both control and infected groups.
Petit
J
J
Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle Hôpital Charles Nicolle, 76031 Rouen-Cédex, France.
Fouin-Fortunet
H
H
Colomb
V
V
Hecketsweiler
B
B
Lemeland
J F
JF
Denis
P
P
Colin
R
R