Chemosensory specific reduction of trigeminal sensitivity in subjects with olfactory dysfunction.
Humans with olfactory loss have been found to exhibit a decreased sensitivity of the chemosensory trigeminal system. It is not clear, whether the reduced trigeminal sensitivity is restricted to the chemosensitive properties of the trigeminal nerve, or whether it reflects a general decrease of trigeminal sensitivity which is also found for cutaneous afferents. To investigate the relationship between cutaneous somatosensory and intranasal chemosensory trigeminal sensitivity, 91 subjects were investigated. Forty-five of them were considered healthy controls, whereas 46 subjects had olfactory dysfunction. Subjects with olfactory dysfunction were found to have higher thresholds for CO2 than controls indicating lower trigeminal chemosensory sensitivity in subjects with olfactory dysfunction. Both etiology and degree of olfactory dysfunction appeared to have an impact on CO2 thresholds. In contrast, no such differences were found with regard to detection thresholds for electrical cutaneous stimulation. These results indicate that the decrease of trigeminal sensitivity in subjects with olfactory dysfunction is specific for chemosensory sensations.
Frasnelli
J
J
Montreal Neurological Institute, McGill University, 3801 University Street, Room 276, Montreal, QC, Canada. johannes.frasnelli@mcgill.ca
Schuster
B
B
Zahnert
T
T
Hummel
T
T
D000328:Adult; D002245:Carbon Dioxide / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology*; D012867:Skin / Q000294:innervation / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000503:physiopathology*
D002245:Carbon Dioxide