title: Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
abstract: Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection.
authors.affiliation: Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Universita di Pavia, via Brambilla, 74, 27100, Pavia, Italy. mdeb@unipv.it
authors.forename: Maurizia
authors.initials: M
authors.lastname: Debiaggi
authors.forename: Filippo
authors.initials: F
authors.lastname: Canducci
authors.forename: Michela
authors.initials: M
authors.lastname: Sampaolo
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Marinozzi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Parea
authors.forename: Cristina
authors.initials: C
authors.lastname: Terulla
authors.forename: Anna Amelia
authors.initials: AA
authors.lastname: Colombo
authors.forename: Emilio Paolo
authors.initials: EP
authors.lastname: Alessandrino
authors.forename: Letizia Zenone
authors.initials: LZ
authors.lastname: Bragotti
authors.forename: Milena
authors.initials: M
authors.lastname: Arghittu
authors.forename: Antonio
authors.initials: A
authors.lastname: Goglio
authors.forename: Roberta
authors.initials: R
authors.lastname: Migliavacca
authors.forename: Egidio
authors.initials: E
authors.lastname: Romero
authors.forename: Massimo
authors.initials: M
authors.lastname: Clementi
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D029121:Metapneumovirus / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000821:virology; D011024:Pneumonia, Viral / Q000453:epidemiology* / Q000821:virology; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons
chemical_list: D012367:RNA, Viral