The effect of infused fat emulsions on reticuloendothelial function in the rabbit.
The effect of the infusion of different fat emulsions (Intralipid and MCT/LCT mixtures) on the reticuloendothelial function of the rabbit has been investigated. Emulsions containing 20% dispersed triglyceride were administered over 6 h to a total of 3 g/kg body weight. The extent of blockade of the reticuloendothelial system was measured using a labelled probe in the form of technetium-99m labelled albumin microspheres. Scintigraphic and blood and organ level determinations demonstrated that all emulsions caused an impairment of reticuloendoethlial function, but this was small.
Davis
S S
SS
Department of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Illum
L
L
Muller
R
R
Landry
F
F
Wright
J
J
Harper
G
G