title: Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.
abstract: Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.
authors.affiliation: Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710-0001, USA. david.seo@duke.edu
authors.forename: David
authors.initials: D
authors.lastname: Seo
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Ginsburg
authors.forename: Pascal J
authors.initials: PJ
authors.lastname: Goldschmidt-Clermont
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics; D020869:Gene Expression Profiling; D006333:Heart Failure / Q000235:genetics / Q000503:physiopathology; D016027:Heart Transplantation / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide