title: Prevalence of Chlamydophila pneumoniae among Bangladeshi children under age 5 years with acute respiratory infections.
abstract: Despite major improvements in the diagnosis of pathogenic organisms causing acute respiratory infections (ARIs), details of infections caused by atypical pathogens are not well understood, particularly in developing countries. This clinical and epidemiological research was conducted in Bangladesh to explore the prevalence of atypical pathogens in causing childhood pneumonia. Sixty-four children with ARI were studied at the Pediatric Outpatient Department of Dhaka Medical College Hospital, Bangladesh, during September through December 2000. In addition to clinical examination, hematological, radiological, and bacteriological examinations were performed. Antibody titers from paired sera against Mycoplasma pneumoniae and Legionella spp. in the acute and convalescent phases revealed that none of these children were infected with M. pneumoniae, while only one serum sample was positive for L. pneumophila serogroup 4. Antibody titers against Chlamydophila (Chlamydia) pneumoniae, determined by an indirect microimmunofluorescence method, and by an enzyme-linked immunosorbent assay (ELISA) kit (HITAZYME C. pneumoniae kit) indicated that 13 children (20.3%) were infected with C. pneumoniae. Our results indicate a high prevalence rate of C. pneumoniae, suggesting it is as an important causative pathogen of childhood pneumonia in Bangladesh.
authors.affiliation: Department of Microbiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. tetsuya@tokyo-med.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Matsumura
authors.forename: Kazi Selim
authors.initials: KS
authors.lastname: Anwar
authors.forename: Abid Hossain
authors.initials: AH
authors.lastname: Mollah
authors.forename: Hinako
authors.initials: H
authors.lastname: Murakami
authors.forename: Intetsu
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kawagoe
authors.forename: Sadashi
authors.initials: S
authors.lastname: Shiga
authors.forename: Toshio
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Nazmun
authors.initials: N
authors.lastname: Nahar
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tateda
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000208:Acute Disease; D001459:Bangladesh / Q000453:epidemiology; D002675:Child, Preschool; D023521:Chlamydophila Infections / Q000453:epidemiology* / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000382:microbiology*