title: Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer.
abstract: OBJECTIVE
  We sought to study the concentrations of certain persistent organic pollutants with endocrine-disrupting properties in cases with prostate cancer and controls with benign prostate hyperplasia.
  
  
  METHODS
  Adipose tissue was obtained from 58 cases and 20 controls.
  
  
  RESULTS
  The median concentration among controls was used as cut-off in the statistical analysis. In the total material, a greater-than median concentration of PCB congener 153 yielded an odds ratio (OR) of 3.15 and 95% confidence interval (CI) of 1.04-9.54 and one chlordane type, trans-chlordane, yielded OR 3.49 (95% CI = 1.08-11.2). In the group of case subjects with PSA levels greater than the median level of 16.5 ng/mL, PCB 153 was OR 30.3 (95% CI = 3.24-284), hexachlorobenzene OR = 9.84 (95% CI = 1.99-48.5), trans-chlordane OR = 11.0 (95% CI = 1.87-64.9), and the chlordane-type MC6 OR = 7.58 (95% CI = 1.65-34.9). The grouping of PCBs according to structural and biological activity was found to produce significantly increased risks for enzyme and phenobarbital-inducing PCBs and lower chlorinated PCBs in the case group with PSA levels greater than 16.5 ng/mL.
  
  
  CONCLUSIONS
  These chemicals might be of etiologic significance but need to be further investigated. The biological relevance of the arbitrary cut-off point of PSA is unclear.
authors.affiliation: Department of Oncology, University Hospital, Orebro, Sweden. lennart.hardell@orebroll.se
authors.forename: Lennart
authors.initials: L
authors.lastname: Hardell
authors.forename: Swen-Olof
authors.initials: SO
authors.lastname: Andersson
authors.forename: Michael
authors.initials: M
authors.lastname: Carlberg
authors.forename: Louise
authors.initials: L
authors.lastname: Bohr
authors.forename: Bert
authors.initials: B
authors.lastname: van Bavel
authors.forename: Gunilla
authors.initials: G
authors.lastname: Lindström
authors.forename: Helen
authors.initials: H
authors.lastname: Björnfoth
authors.forename: Claes
authors.initials: C
authors.lastname: Ginman
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011078:Polychlorinated Biphenyls / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000032:analysis; D011470:Prostatic Hyperplasia / Q000209:etiology*; D018570:Risk Assessment; D013222:State Medicine; D013548:Sweden
chemical_list: D011078:Polychlorinated Biphenyls; D017430:Prostate-Specific Antigen