title: The role of sex in cardiac function and disease.
abstract: In the past decade, increasing attention has been paid to the importance of sex in the etiology of cardiac dysfunction. While focus has been primarily on how sex modulates atherogenesis, it is becoming clear that sex is both a predictor of outcome and an independent risk factor for a number of other cardiac diseases. Animal models and human studies have begun to shed light on the mechanisms by which sex influences the function of cardiomyocytes in health and disease. This review will survey the current literature on cardiac diseases that are influenced by sex and discuss the intracellular mechanisms by which steroid sex hormones affect heart function. A theory on how sex may regulate myocardial energy metabolism to affect disease susceptibility and progression will be presented, as well as a discussion of how sex may influence outcomes of experiments on isolated cardiomyocytes by epigenetic marking.
authors.affiliation: Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, Winnipeg, MB, Canada. mczubryt@sbrc.ca
authors.forename: Michael P
authors.initials: MP
authors.lastname: Czubryt
authors.forename: Leon
authors.initials: L
authors.lastname: Espira
authors.forename: Lise
authors.initials: L
authors.lastname: Lamoureux
authors.forename: Bernard
authors.initials: B
authors.lastname: Abrenica
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D004198:Disease Susceptibility; D004967:Estrogens / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006321:Heart / Q000502:physiology; D006801:Humans; D008297:Male; D011372:Progestins / Q000378:metabolism; D012737:Sex Factors
chemical_list: D000728:Androgens; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011372:Progestins; D001141:Aromatase