title: Complications, urinary continence, and oncologic outcome of 1000 laparoscopic transperitoneal radical prostatectomies-experience at the Charité Hospital Berlin, Campus Mitte.
abstract: OBJECTIVE
  Laparoscopic transperitoneal radical prostatectomy (LRP) is an alternative to open radical prostatectomy, but data based on large populations are not frequently available. This study was initiated to evaluate LRP with regard to complications, urinary continence, and oncologic outcome.
  
  
  METHODS
  We retrospectively reviewed 1000 consecutive patients with a mean age of 62 yr (SD+/-6 yr) and clinically localized prostate cancer. Between May 1999 and October 2004, all 1000 patients underwent LRP performed by eight urologists at one institution (Charité Hospital Berlin, Campus Mitte). The review procedure was based on complete patient documents (hospital stay, n=1000) and an interview by one physician. Histopathologic results, intraoperative and early and late complications, continence rate, and time to first PSA increase (n=952) were recorded. Erectile function was not part of this review. Twenty-two patients received neoadjuvant treatment for >2 mo.
  
  
  RESULTS
  The median follow-up was 28.8 mo (range: 7.2 to 69.7). Intraoperative and early complications occurred in 11.8% of patients. In 77.6% the urethrovesical anastomosis tested by cystography at day 5 or 6 after LRP was intact; 76% used none or not more than one pad per 24h. The overall PSA-free survival was more than 90% for pT2, 80.3% for pT3a, and 72.4% for pT3b until July 2005. The mortality rate was 0.3%.
  
  
  CONCLUSIONS
  In the present series of 1000 patients, a specific disadvantage of LRP compared with the open approach, as reported in the literature, could not be shown. On the basis of short-term follow-up data, our retrospective evaluation confirms that LRP provides satisfactory results. We believe that laparoscopic radical prostatectomy can be the technique of choice in the future.
authors.affiliation: Department of Urology, Charité Hospital Berlin, Campus Mitte, University Medicine Berlin, Germany. michael.lein@charite.de <michael.lein@charite.de>
authors.forename: Michael
authors.initials: M
authors.lastname: Lein
authors.forename: Inna
authors.initials: I
authors.lastname: Stibane
authors.forename: Ramin
authors.initials: R
authors.lastname: Mansour
authors.forename: Claudia
authors.initials: C
authors.lastname: Hege
authors.forename: Jan
authors.initials: J
authors.lastname: Roigas
authors.forename: Andreas
authors.initials: A
authors.lastname: Wille
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schnorr
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Loening
authors.forename: Serdar
authors.initials: S
authors.lastname: Deger
mesh_terms: D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D014563:Urodynamics / Q000502:physiology*
chemical_list: D017430:Prostate-Specific Antigen