Lipoprotein(a) as a risk factor associated with ischemic heart disease: Ouro Preto Study.
Evidences suggest that lipoprotein(a) [Lp(a)] is an important risk factor for cardiovascular disease. However, literature has been controversial in confirming its role as an independent risk factor for cardiovascular disease. The objective of the present study is to evaluate the association between serum levels of Lp(a) and ischemic heart disease as well as other cardiovascular risk factors in a population-based study conducted on a local cohort of the Brazilian population. Lp(a) serum levels were measured in 400 individuals selected from a larger sample of a populational survey carried out in Ouro Preto, a city in the southeast of Brazil. Lipid profile, fasting blood glucose, anthropometric and clinical parameters were analyzed. Lp(a) levels were significantly associated with the presence of ischemic heart disease. In relation to other cardiovascular risk factors, it was verified that Lp(a) levels were statistically associated with age, total cholesterol, LDL-cholesterol and percentage of body fat determined by bioelectric impedance. Lp(a) was also highly associated with the Framingham risk score (p=0.003). In a multivariate analysis two significant interactions were revealed; one involving ischemic heart disease, sex and age and other associating ischemic heart disease, age and total cholesterol. In summary, in the present analysis Lp(a) serum levels were correlated with the occurrence of ischemic heart disease and other cardiovascular risk factors.
Cândido
Ana Paula Carlos
AP
Departamento de Farmácia, Universidade Federal de Ouro Preto, Rua Costa Sena 171, 35400-000 Ouro Preto, Minas Gerais, MG, Brazil.
Ferreira
Silvania
S
Lima
Angélica Alves
AA
de Carvalho Nicolato
Roney Luiz
RL
de Freitas
Sílvia Nascimento
SN
Brandão
Paulo
P
Pereira
Alexandre
A
Krieger
José Eduardo
JE
do Nascimento-Neto
Raimundo Marques
RM
Machado-Coelho
George Luiz Lins
GL
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D050218:Body Fat Distribution; D001938:Brazil; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology*; D009765:Obesity / Q000097:blood / Q000150:complications; D011159:Population Surveillance; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors
D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D002784:Cholesterol