title: Late gadolinium-enhanced cardiovascular magnetic resonance identifies patients with standardized definition of ischemic cardiomyopathy: a single centre experience.
abstract: BACKGROUND
  Definition of ischemic cardiomyopathy (IC) is not always obvious, which is why new criteria based on prognosis and the extent of the coronary artery disease (CAD) have been proposed. In the present study, we assess the capability of late gadolinium-enhanced cardiovascular magnetic resonance (CMR) for predicting IC as determined by standardized criteria previously reported.
  
  
  RESULTS
  123 patients with heart failure (HF) and left ventricular (LV) systolic dysfunction, underwent both late gadolinium-enhanced CMR and coronary angiography 37/123 (30%) of patients were assigned to the IC group and 86/123 (70%) to the non-IC group. Subendocardial late gadolinium enhancement (LGE) was found in 35/37 (94%) of patients in the IC group, whereas only 12/86 (14%) had this distribution in the non-IC group (p<0.001). There was a significant positive correlation between the extent of subendocardial LGE and that of the CAD as determined by the CAD Prognostic Index (r=0.78, p<0.01), the number of coronary stenoses > or = 50% (r=0.76, p<0.01) and the number of coronary stenoses of any percentage (r=0.70, p<0.01).
  
  
  CONCLUSIONS
  In patients with HF and LV systolic dysfunction presence of subendocardial LGE makes an excellent indicator of underlying significant CAD, and the extent of the LGE correlates with the severity of the disease. It is therefore appealing as a method for diagnosing IC.
authors.affiliation: Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Spain.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Soriano
authors.forename: Francisco
authors.initials: F
authors.lastname: Ridocci
authors.forename: Jordi
authors.initials: J
authors.lastname: Estornell
authors.forename: José L
authors.initials: JL
authors.lastname: Pérez-Boscá
authors.forename: Francisco
authors.initials: F
authors.lastname: Pomar
authors.forename: Alberto
authors.initials: A
authors.lastname: Trigo
authors.forename: Ana
authors.initials: A
authors.lastname: Planas
authors.forename: Mercedes
authors.initials: M
authors.lastname: Nadal
authors.forename: Victoria
authors.initials: V
authors.lastname: Jacas
authors.forename: Vicente
authors.initials: V
authors.lastname: Martinez
authors.forename: Rafael
authors.initials: R
authors.lastname: Paya
mesh_terms: D000368:Aged; D002303:Cardiac Output, Low / Q000150:complications / Q000175:diagnosis; D002319:Cardiovascular System / Q000473:pathology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis; D004699:Endocardium / Q000473:pathology; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D005682:Gadolinium