title: Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury.
abstract: The effect of dietary lipids on bacterial translocation, killing of translocated organisms and host survival was studied in a burned animal model. Balb/c mice were fed with one of the three experimental AIN-76A diets (containing 15% of energy from fish oil, safflower oil or a 50:50 mixture), AIN-76A without added lipids or a nonpurified stock diet. All animals were transfused on day 10. On day 15, the animals were gavaged with 10(10) 14C radiolabelled Escherichia coli and given a 20% burn injury. Survival was 84% in the fish oil group versus 36% in the safflower oil and 50:50 diet groups, and 25% and 20% in the two control groups (P < 0.0001). The numbers of viable translocating bacteria were reduced in all tested organs in the fish oil groups compared to the other groups. It is concluded that a diet enriched in fish oil has beneficial effects during gut-derived sepsis.
authors.affiliation: University of Cincinnati College of Medicine, Department of Surgery, Transplantation Division, and Shriners BurnsInstitute, Cincinnati, Ohio, USA.
authors.forename: L
authors.initials: L
authors.lastname: Gianotti
authors.forename: J W
authors.initials: JW
authors.lastname: Alexander
authors.forename: T
authors.initials: T
authors.lastname: Eaves-Pyles
authors.forename: R
authors.initials: R
authors.lastname: Fukushima