A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant.
Tyloxapol (Triton WR 1339) is a non-ionic detergent that inhibits lipoprotein lipase and thereby raises levels of serum lipids. It is used frequently for acute studies on lipids in rats but not for subacute or chronic studies. In the present work, we found that tyloxapol must be injected intravenously three times each week in order to have high and sustained levels of serum cholesterol and triglycerides for 1, 2, or 3 weeks. These results make it possible to extend the use of tyloxapol into chronic studies of hyperlipemia and vascular disease.
Levine
Seymour
S
Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. LEVINES@NKI.RFMH.org
Saltzman
Arthur
A
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000633:toxicity*; D006949:Hyperlipidemias / Q000139:chemically induced*; D007275:Injections, Intravenous; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors*; D011092:Polyethylene Glycols / Q000633:toxicity*; D051381:Rats; D011917:Rats, Inbred Lew; D013501:Surface-Active Agents / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood
D004791:Enzyme Inhibitors; D013501:Surface-Active Agents; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; D008071:Lipoprotein Lipase; C016811:tyloxapol