[What is the best strategy of hormonal therapy in the treatment of locally advanced prostate cancer?].
We retrospectively studied patients with clinical stage C-D1 prostate cancer in Gifu University and affiliated hospitals. The overall survival rate of patients treated with hormonal therapy after radical prostatectomy was superior to that of patients treated with hormonal therapy alone. This result was remarkable in the patients under 76 years old with clinical stage C. A PubMed search of the literature on various randomized controlled trials revealed that the overall survival rate of patients treated with hormonal therapy alone was inferior to that treated with adjuvant hormonal therapy. We recommend prospective evaluation of combined therapy including prostatectomy, radiotherapy and hormonal therapy for the patient with a risk factor such as high Gleason score.
Ehara
Hidetoshi
H
The Department of Urology, Graduate School of Medicine, Gifu University.
Nakano
Masahiro
M
Deguchi
Takashi
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate
D018931:Antineoplastic Agents, Hormonal