title: Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.
abstract: Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.
authors.affiliation: Department of Molecular and Clinical Endocrinology & Oncology, Federico II University, Naples, Italy. giovannella.palmieri@email.it
authors.forename: Giovannella
authors.initials: G
authors.lastname: Palmieri
authors.forename: Carmine
authors.initials: C
authors.lastname: Selleri
authors.forename: Liliana
authors.initials: L
authors.lastname: Montella
authors.forename: Goffredo
authors.initials: G
authors.lastname: Bulgarelli
authors.forename: Laura
authors.initials: L
authors.lastname: Vitiello
authors.forename: Ghassan
authors.initials: G
authors.lastname: Merkabaoui
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ricci
authors.forename: Luigi
authors.initials: L
authors.lastname: Del Vecchio
authors.forename: Annamaria
authors.initials: A
authors.lastname: Masci
authors.forename: Luigi
authors.initials: L
authors.lastname: Racioppi
authors.forename: Bruno
authors.initials: B
authors.lastname: Rotoli
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013945:Thymoma / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology* / Q000628:therapy
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta