[The expressions of protein kinase CK2alpha in squamous cell carcinoma of larynx and its clinical significance].
OBJECTIVE
To investigate the expression of Protein kinase CK2alpha in squamous cell carcinoma of larynx (LSCC) and to evaluate its clinical significance.


METHODS
The expressions of protein kinase CK2alpha protein in 50 cases of LSCC tissues and 10 cases of normal mucous membrane of palatoglossal pillar were studied by using immunohistochemical SP staining method and quantitative analysis of image.


RESULTS
The positive rate of Protein kinase CK2alpha staining was 64% (32/50) in LSCC tissues,while only 30% (3/10) in normal mucous membrane of palatoglossal pillar (P <0.05). A significant difference was observed for the average absorbance value (A value) of protein kinase CK2alpha positive expression in two groups (P <0.05). No correlation was found between A value of protein kinase CK2alpha positive expression and sex, age, tumor sites, TNM stage and lymphatic metastasis, but there was significant correlation between A value of protein kinase CK2alpha positive expression and differentiation grading (G1-->G2 +G3) (P <0.05).


CONCLUSIONS
The over expression of Protein kinase CK2alpha is closely related to the formation and development of LSCC. Protein kinase CK2alpha may be one of the predictors for the malignant grade of LSCC. To inhibit the over expression might be new therapeutic methods for LSCC.
Wang
Jianting
J
Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Gong
Shusheng
S
Liu
Yingpeng
Y
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D047390:Casein Kinase II / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D007830:Larynx / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D047390:Casein Kinase II