Immune thrombocytopenic purpura associated with pulmonary tuberculosis.
A 22-year-old woman was admitted into our hospital because of generalized purpura and abnormalities in her chest X-ray. Isolated thrombocytopenia and elevated platelet-associated IgG levels were detected, while the bone marrow examination was normal. Mycobacterium tuberculosis was detected in the bronchoalveolar lavage fluid, and consequently she was diagnosed as having active tuberculosis. High-dose immunoglobulin therapy combined with anti-tuberculosis drugs not only rapidly and continuously corrected thrombocytopenia but also cured pulmonary tuberculosis. This case suggests a causal association between immune thrombocytopenia and tuberculosis as well as the safety and efficacy of the anti-tuberculosis drugs combined with high-dose immunoglobulin therapy.
Tsuro
Kiminori
K
Department of Gastroenterology and Metabology, Toon, Ehime University Graduate School of Medicine.
Kojima
Hideyuki
H
Mitoro
Akira
A
Yoshiji
Hitoshi
H
Fujimoto
Masao
M
Uemura
Masahito
M
Masahide
Yoshikawa
Y
Fukui
Hiroshi
H
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy
D000995:Antitubercular Agents