title: An alternative treatment strategy for pump thrombus in the DeBakey VAD Child: use of clopidogrel as a thrombolytic agent.
abstract: Our institution has used the DeBakey VAD Child as a bridge to heart transplantation in select pediatric patients. Pump thrombus is a potentially serious complication with few available treatment options. Only surgical device exchange or the use of tissue plasminogen activator are reported in the literature. We report the use of clopidogrel as an alternative thrombolytic agent in the presence of pump thrombus in an adolescent patient with a DeBakey VAD Child heart pump.
authors.affiliation: Lillie Frank Abercrombie Section of Pediatric Cardiology, Department of Pediatrics (Cardiology, Critical Care), Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin, MC 19345-C, Houston 77030, USA. mastuder@texaschildrenshospital.org
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Studer
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Kennedy
authors.forename: William J
authors.initials: WJ
authors.lastname: Dreyer
authors.forename: Jack F
authors.initials: JF
authors.lastname: Price
authors.forename: Brady S
authors.initials: BS
authors.lastname: Moffett
authors.forename: Edward R
authors.initials: ER
authors.lastname: Teitel
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Carberry
authors.forename: David L S
authors.initials: DL
authors.lastname: Morales
authors.forename: E Dean
authors.initials: ED
authors.lastname: McKenzie
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D001241:Aspirin / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D000077144:Clopidogrel; D004868:Equipment Failure; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D014859:Warfarin; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin