title: Novel selenoorganic compounds as modulators of oxidative stress in blood platelets.
abstract: Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors, or drugs. The effects of five new synthesized selenoorganic compounds (2-(5-chloro-2-pyridyl)-7-azabenzisoselenazol-3(2H)-one; 2-phenyl-7-azabenzisoselenazol-3(2H)-one; 2-(pyridyl)-7-azabenzisoselenazol-3(2H)-one; 7-azabenzisoselenazol-3(2H)-one; bis(2-aminophenyl) diselenide) on oxidative changes in human blood platelets and in plasma were studied in vitro and compared with those of ebselen, a well known antioxidant. Our studies demonstrated that bis(2-aminophenyl) diselenide has distinctly protective effects against oxidative stress in blood platelets and in plasma. It might have greater biological relevance and stronger pharmacological effects than ebselen.
authors.affiliation: Department of General Biochemistry, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland. juszczak@biol.uni.lodz.pl
authors.forename: J
authors.initials: J
authors.lastname: Saluk-Juszczak
authors.forename: B
authors.initials: B
authors.lastname: Wachowicz
authors.forename: H
authors.initials: H
authors.lastname: Wójtowicz
authors.forename: K
authors.initials: K
authors.lastname: Kloc
authors.forename: E
authors.initials: E
authors.lastname: Bald
authors.forename: R
authors.initials: R
authors.lastname: Glowacki
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D016566:Organoselenium Compounds / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D016566:Organoselenium Compounds; D005978:Glutathione