title: [Clinical usefulness of 201Tl/99mTc-PYP dual myocardial quantitative gated SPECT program using low-dose dobutamine loading in assessment of myocardial viability in patient with acute myocardial infarction--a case report].
abstract: An 86-year-old man with chest pain was admitted to our hospital. Coronary angiography revealed 99% stenosis of the mid segment of the left anterior descending coronary artery, therefore, a coronary stent was implanted. Immediately after the stent implantation, 99% stenosis occurred at the proximal site of the 1st diagonal artery because of stent jeal. On the 4th hospital day, ECG-gated 201TL/99mTc-PYP dual myocardial quantitative gated SPECT was performed at rest and during low-dose dobutamine loading. The 201Tl scintigraphy revealed moderately reduced uptake in the anterior, septal and apical walls, and 99mTc-PYP uptake was observed in the mid-anterior wall. A three-dimensional surface display of gated 201Tl SPECT images showed severe hypokinesis in the anterior, septal and apical walls at rest. On the other hand, during low-dose dobutamine loading, improved wall motion was observed in the basal anterior and septal walls, while no change was observed in the midanterior and apical wall movements. Three-dimensional surface display of gated 201Tl/99mTc-PYP dual SPECT images revealed similar patterns of wall motion as those of gated 201Tl SPECT images at rest. During low-dose dobutamine loading, on the other hand, a three-dimensional surface display of gated 201Tl/99mTc-PYP dual SPECT images revealed improved wall motion in the basal anterior, septal and apical walls, but worsened wall motion of the mid-anterior wall. After 6 months, a follow-up coronary angiography revealed no re-stenosis of the stent, but 99% stenosis at the proximal aspect of the 1st diagonal artery. Left ventriculography revealed improved wall motion in the apex and akinesis of the mid-anterior wall. These wall motion findings were similar to those visualized in the three-dimensional surface display of gated 201Tl/99mTc-PYP dual SPECT images during low-dose dobutamine loading in the acute phase. These results suggest that 201Tl/99mTc-PYP dual myocardial quantitative gated SPECT using low-dose dobutamine loading could be useful for the assessment of myocardial viability after reperfusion therapy in patients with acute myocardial infarction.
authors.affiliation: Department of Cardiology, Kouseikai Takeda Hospital.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Irie
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koide
authors.forename: Takuya
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Yokoi
authors.forename: Reo
authors.initials: R
authors.lastname: Nakamura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Shunichi
authors.initials: S
authors.lastname: Tamaki
authors.forename: Takahisa
authors.initials: T
authors.lastname: Sawada
authors.forename: Akihiro
authors.initials: A
authors.lastname: Azuma
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000369:Aged, 80 and over; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D004280:Dobutamine; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D019275:Radiopharmaceuticals; D015607:Stents; D016698:Technetium Tc 99m Pyrophosphate; D014022:Tissue Survival; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D004280:Dobutamine; D016698:Technetium Tc 99m Pyrophosphate