title: Bronchial hyperresponsiveness, atopy, and bronchoalveolar lavage eosinophils in persistent middle lobe syndrome.
abstract: Most cases of middle lobe syndrome (MLS) in children are considered to be due to asthma and may recover spontaneously; however, in persistent MLS, repeated episodes of infection often institute a vicious cycle that may lead to persistent symptoms and bronchial hyperresponsiveness (BHR). The present study was undertaken to investigate whether asthma, as an underlying diagnosis, is predictive of a favorable outcome of children with persistent MLS. We evaluated 53 children with MLS who underwent an aggressive management protocol that included fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL). These patients were compared to two other groups: one consisting of children with current asthma but no evidence of MLS (N = 40) and another of non-asthmatic controls (N = 42), matched for age and sex. Prevalence of sensitization (>or=1 aeroallergen) did not differ between patients with MLS and "non-asthmatics" but was significantly lower than that of "current asthmatics." A positive response to methacholine bronchial challenge was observed with increased frequency among children with MLS when compared to "current asthmatic" and non-asthmatic children. Multivariate logistic regression analysis revealed a positive correlation between an increased number of eosinophils in the BAL fluid (BALF) and a favorable outcome, whereas no correlation was detected between sensitization or BHR and BAL cellular components. In conclusion, children with MLS have an increased prevalence of BHR, even when compared to asthmatics, but exhibit prevalence of atopy similar to that of non-asthmatics. An increased eosinophilic BALF count is predictive of symptomatic but not radiographic improvement of MLS patients after aggressive anti-asthma management.
authors.affiliation: Department of Allergy-Pneumonology, Penteli Children's Hospital, Penteli, Greece. kpriftis@otenet.gr
authors.forename: Kostas N
authors.initials: KN
authors.lastname: Priftis
authors.forename: Michael B
authors.initials: MB
authors.lastname: Anthracopoulos
authors.forename: Despina
authors.initials: D
authors.lastname: Mermiri
authors.forename: Athina
authors.initials: A
authors.lastname: Papadopoulou
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Xepapadaki
authors.forename: Constantina
authors.initials: C
authors.lastname: Tsakanika
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Nicolaidou
mesh_terms: D001249:Asthma / Q000150:complications*; D016535:Bronchial Hyperreactivity / Q000150:complications*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004804:Eosinophils; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D007223:Infant; D008297:Male; D008878:Middle Lobe Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy