Biphasic anaphylactic reaction to Ketorolac tromethamine.
Ketorolac tromethamine is a recent injectable non-steroidal anti-inflammatory drug (NSAID) with analgesic properties approved for short-term pain management. In spite of its increasing use both in adults and children, relatively few allergic-like reactions have been reported. Reactions are often severe, and a death occurred following an intramuscular injection of ketorolac.
Novembre
E
E
Allergy and Clinical Immunology Unit, Azienda Ospedaliero Universitaria A. Meyer, Via L. Giordano 13, 50132 Florence, Italy. e.novembre@meyer.it
Calogero
C
C
Mori
F
F
Bernardini
R
R
Pucci
N
N
Neri
P
P
Bonini
M
M
Vierucci
A
A
De Martino
M
M
D000293:Adolescent; D000707:Anaphylaxis / Q000188:drug therapy / Q000503:physiopathology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002744:Chlorpheniramine / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D020911:Ketorolac Tromethamine / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use; D012882:Skin Tests; D014581:Urticaria / Q000209:etiology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine; D020911:Ketorolac Tromethamine; D008775:Methylprednisolone