SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences.
The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.
Han
Areum
A
National Genome Information Center (NGIC), Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-guDaejeon 305-333, Korea.
Kang
Hyo Jin
HJ
Cho
Yoobok
Y
Lee
Sunghoon
S
Kim
Young Joo
YJ
Gong
Sungsam
S
D003196:Computer Graphics; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary / Q000235:genetics*; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface