The identification of new protein kinase inhibitors as targets in modern drug discovery.
In recent years there has been great interest in developing protein kinase inhibitors as therapeutic agents for a variety of diseases. This article provides an overview on the history, development and validity of kinases as drug targets, as well as a description of kinase research, including its limitations, challenges and successes.
Akritopoulou-Zanze
Irini
I
Abbott Laboratories, Department 4CP, Building AP10-1, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com
D020134:Catalytic Domain; D003920:Diabetes Mellitus / Q000188:drug therapy; D015195:Drug Design; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D009422:Nervous System Diseases / Q000188:drug therapy; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000266:history / Q000302:isolation & purification*; D011494:Protein Kinases / Q000737:chemistry
D047428:Protein Kinase Inhibitors; D011494:Protein Kinases