title: Juxtaposed half-cystines as disulphide bridged partners in protein tertiary structure.
abstract: Disulphide bridges involving juxtaposed half-cystines are observed in a number of protein three-dimensional structures analyzed from the Protein Data Bank. These disulphide bridges comprise a 'ring of 8-atoms' corresponding to Calpha1-C'-N-Calpha2-Cbeta2-Sgamma2-Sgamma1-Cbeta1-Calpha1 in the two half-cystines. The presence of such disulphide bridges introduces a 'bend' or 'kink' in the protein polypeptide chain.
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India. guru@ccmb.res.in
authors.forename: Kunchur
authors.initials: K
authors.lastname: Guruprasad
authors.forename: V Jai
authors.initials: VJ
authors.lastname: Kartik
authors.forename: T
authors.initials: T
authors.lastname: Lavanya
authors.forename: Lalitha
authors.initials: L
authors.lastname: Guruprasad
mesh_terms: D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism*; D004220:Disulfides / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004220:Disulfides; D011506:Proteins; D003545:Cysteine