Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives.
A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.
Oh
Seikwan
S
Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University 38677-1848, USA.
Jang
Soyong
S
Kim
Donghyun
D
Han
Inn-Oc
IO
Jung
Jae-Chul
JC
D000818:Animals; D001713:Biphenyl Compounds; D002460:Cell Line; D002470:Cell Survival; D002540:Cerebral Cortex / Q000187:drug effects / Q000196:embryology; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D036381:Diarylheptanoids / Q000138:chemical synthesis / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology*; D018698:Glutamic Acid; D006834:Hydrazines; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009573:Nitrites / Q000378:metabolism; D010851:Picrates; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D036381:Diarylheptanoids; D016166:Free Radical Scavengers; D006834:Hydrazines; D018696:Neuroprotective Agents; D009573:Nitrites; D010851:Picrates; C121978:yakuchinone B; D018698:Glutamic Acid; D002599:Chalcone; C004931:1,1-diphenyl-2-picrylhydrazyl