title: [Soft tissue manifestations of early rheumatic disease: imaging with MRI].
abstract: OBJECTIVE
  The aim of this study was to evaluate typical magnetic resonance imaging (MRI) findings in early rheumatic diseases manifesting at the soft tissues of the hand using a retrospective analysis.
  
  
  METHODS
  A total of 186 MRI examinations of patients with clinical suspicion of a rheumatic disease were evaluated in a consensus reading by two experienced radiologists. All imaging patterns were assessed with respect to their type and localization. Under blinded and non-blinded conditions diagnoses were correlated with final clinical diagnosis.
  
  
  RESULTS
  The most frequent diagnoses were rheumatoid arthritis (RA, 45.7%) and psoriatic arthritis (PsA, 15.6%). The mean correlation between clinical and MRI diagnosis (r) was 0.75 in blinded and 0.853 in non-blinded reading (p <0.001). The following extra-articular imaging patterns were found: synovitis (59.1%), tendovaginitis (91.4%), dactylitis (14.5%), and bone marrow edema (18.3%). Only dactylitis was specific for a particular rheumatic disease (PsA; r=0.934; sensitivity 84.9%, specificity 82.4%).
  
  
  CONCLUSIONS
  Inflammatory conditions of the hand can be reliably detected with MRI. In many cases the definite diagnosis can only be made when taking clinical, serological, and radiographic results into account (+13.7% increase of significance).
authors.affiliation: Institut für Klinische Radiologie, Klinikum Innenstadt der Ludwig-Maximilians-Universität, Pettenkoferstr. 8a, 80336, München. Marcus.Treitl@med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Treitl
authors.forename: A
authors.initials: A
authors.lastname: Panteleon
authors.forename: M
authors.initials: M
authors.lastname: Körner
authors.forename: C
authors.initials: C
authors.lastname: Becker-Gaab
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: S
authors.initials: S
authors.lastname: Wirth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003240:Connective Tissue Diseases / Q000175:diagnosis*; D005260:Female; D006225:Hand / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000175:diagnosis*; D012680:Sensitivity and Specificity