Bis-(2-amino-5-selenazoyl) ketone as a superoxide anion-scavenger.
We investigated the superoxide anion scavenging effects of 2-amino-1,3- selenazoles and bis-(2-amino-5-selenazoyl) ketones using a highly sensitive quantitative chemiluminescence method. At 166 microM, the 2-amino-1,3-selenazoles and bis-(2-amino-5-selenazoyl) ketones scavenged in the range of 10.0 to 80.0% of O(2)(-). Bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone exhibited the strongest superoxide anion-scavenging activity among the six kinds of 2-amino-1,3-selenazoles and three kinds of bis-(2-amino-5-selenazoyl) ketones. The 50% inhibitory concentration (IC(50)) of bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone was determined to be 37.1 microM. Thus, bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone acted in vitro as effective and potentially useful O(2)(-) scavenger.
Sekiguchi
Akihiro
A
Gunma Industrial Technology Center, Japan.
Nishina
Atsuyoshi
A
Kimura
Hirokazu
H
Fukumoto
Ryo-hei
RH
Kogami
Masakazu
M
Ishihara
Hideharu
H
Koketsu
Mamoru
M
D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D007659:Ketones / Q000494:pharmacology*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D016566:Organoselenium Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000187:drug effects / Q000378:metabolism
D016166:Free Radical Scavengers; D007659:Ketones; D016566:Organoselenium Compounds; D013481:Superoxides; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase