[The protective action of essentiale, riboxin, and elkar against hemotoxic anemia].
The introduction of phenylhydrazine in rats inhibited the hemopoiesis, decreased the functional activity of immune cells, hepatocytes and myocytes, and reduced the work capacity. The combined administration of essentiale and riboxin decreased the expression of inhibition of the nonspecific resistance and immune reactivity in rats pretreated with phenylhydrazine. The combined use of essentiale and elkar produced a hepatoprotective effect in rats with phenylhydrazine-induced hemotoxic anemia. Elkar in combination with riboxin enhance the physical work capacity in rats poisoned by the hemotropic toxin. The pairwise drug injections did not influence the reduced content of erythrocytes and hemoglobin in the blood caused by phenylhydrazine. However, the combined injection of all the three drugs (essentiale, riboxin and elkar) decreased the expression of hemopoiesis inhibition.
Lazareva
G A
GA
Brovkina
I L
IL
D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006410:Hematopoiesis / Q000187:drug effects; D007155:Immunologic Factors / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects; D016877:Oxidants / Q000633:toxicity; D010659:Phenylhydrazines / Q000633:toxicity; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D007155:Immunologic Factors; D016877:Oxidants; D010659:Phenylhydrazines; D010713:Phosphatidylcholines; D020011:Protective Agents; C030299:phenylhydrazine; C011246:essential 303 forte; D007290:Inosine Diphosphate