Functionalization of biomaterials and cell to cell communication.
In the field of osseous substitution, the possibilities being offered to the surgeons prove sometimes difficult to apply in particular in the case of great losses of osseous substance. For these reasons, it is necessary to develop innovative techniques to satisfy the request increasing for substitutes and to see appearing on the market solutions combining availability, perenniality and biosecurity of the implants. The implantation of stem cells in a biomaterial opens a way of development of therapeutic substitute. Moreover, in order to optimize the rehabitation of the biomaterials by the cells and the host tissues, the second approach consists in modifying the surface of materials by the coating or the grafting of adhesive factors in order to stimulate their colonization. At least, one cannot consider a tissue mechanism of repair without a better knowledge of the respective role of the various cell populations implied in the rebuilding of this tissue and their cell to cell communication processes.
Amédée
J
J
INSERM, U577, Bordeaux, F-33076 France, Université Victor Segalen, Bordeaux, Cedex, France. joelle.amedee@bordeaux.inserm.fr
Guillotin
B
B
Pallu
S
S
Bareille
R
R
Guignandon
A
A
Bourget
Ch
Ch
Durrieu
M C
MC
Bordenave
L
L
D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002450:Cell Communication; D017690:Cell Transplantation; D018920:Coculture Techniques; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D016348:Osseointegration; D010455:Peptides / Q000737:chemistry; D013234:Stem Cells / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry
D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D010455:Peptides; D014025:Titanium