title: Heliconols A-C: antimicrobial hemiketals from the freshwater aquatic fungus Helicodendron giganteum.
abstract: [Structure: see text] Cultures of the freshwater aquatic fungus Helicodendron giganteum afforded three new compounds, heliconols A-C (1-3), that contain an unusual reduced furanocyclopentane unit. The structures of these metabolites were assigned by analysis of 1D and 2D NMR data. The absolute configuration of heliconol A (1) was assigned by single-crystal X-ray crystallographic analysis of its dibromobenzoate derivative. Heliconol A showed antifungal and antibacterial activities in disk diffusion assays.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Sanjay V
authors.initials: SV
authors.lastname: Mudur
authors.forename: Dale C
authors.initials: DC
authors.lastname: Swenson
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
authors.forename: Jinx
authors.initials: J
authors.lastname: Campbell
authors.forename: Carol A
authors.initials: CA
authors.lastname: Shearer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry*; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; C519411:heliconol A; C519412:heliconol B; C519413:heliconol C