[Relationship between dopamine-beta-hydroxylase gene polymorphism and hypertensive disorder complicating pregnancy].
OBJECTIVE
To investigate the association between the single nucleotide polymorphism (SNP) at locus 589 of dopamine-beta-hydroxylase (DbetaH) gene and hypertensive disorder complicating pregnancy (HDCP).


METHODS
One hundred and seven pregnant women with hypertensive disorder complicating pregnancy (HDCP group) and 95 normal pregnant women (control group) matched for age and gestation were selected. Genotypes of the SNP at locus 589 were typed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
(1) The frequencies of DbetaH GG, GA and AA genotypes of the SNP at locus 589 were 75.7%, 21.5% and 2.8% in HDCP group, respectively. They were 72.6%, 24.2% and 3.2% in normal control group, respectively (P > 0.05). The frequencies of the two alleles G and A were 86.4% and 13.6% in HDCP group, and 84.7% and 15.3% in normal control group, respectively (P > 0.05). (2) No evident differences existed in distribution of genotypes of the SNP at locus 589 between mild preeclampsia, severe preeclampsia and eclampsia groups (P > 0.05).


CONCLUSIONS
The SNP at locus 589 of DbetaH gene is not associated with hypertensive disorder complicating pregnancy, nor is it associated with the severity of hypertensive disorder complicating pregnancy.
Zhu
He
H
Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041, China.
Zhao
Yan-hui
YH
Zhang
Wei-yuan
WY
Guan
Qi-yu
QY
Zhang
Xiu-hua
XH
D000328:Adult; D000483:Alleles; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D004461:Eclampsia / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index
D004299:Dopamine beta-Hydroxylase