Architecture of the SARS coronavirus prefusion spike.
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.
Beniac
Daniel R
DR
Viral Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, R3E 3R2, Canada.
Andonov
Anton
A
Grudeski
Elsie
E
Booth
Tim F
TF
D000818:Animals; D002522:Chlorocebus aethiops; D015925:Cryopreservation / Q000379:methods; D000939:Epitopes / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008561:Membrane Fusion / Q000502:physiology; D008854:Microscopy, Electron / Q000379:methods; D008958:Models, Molecular; D045473:Severe acute respiratory syndrome-related coronavirus / Q000737:chemistry / Q000472:pathogenicity / Q000648:ultrastructure*; D014709:Vero Cells / Q000821:virology; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000378:metabolism; D014771:Virion / Q000737:chemistry
D000939:Epitopes; D014759:Viral Envelope Proteins