Disseminated granuloma annulare: efficacy of cyclosporine therapy.
Granuloma annulare is an anatomo-clinical entity that is frequently encountered in everyday dermatological practice. We report our experience regarding 4 patients with disseminated granuloma annulare. Each patient was treated with a cycle of cyclosporine therapy for six weeks. A cycle of systemic cyclosporine therapy was started at a dose of 4 mg/kg/day for four weeks, subsequently reduced by 0.5 mg/kg/day every two weeks. The clinical picture more or less completely resolved within three weeks in all of the patients, and there were no relapses during the dose-tapering period or the following 12 months. Cyclosporine was optimally tolerated by all four patients, none of whom experienced any therapy-related side effects. Cyclosporine is a valid therapeutic option for the treatment of disseminated granuloma annulare, although we recommend its use in a protected hospital environment that facilitates patient monitoring.
Spadino
S
S
Institute of Dermatology, University of Milan, IRCCS Galeazzi Orthopedic Institute, Via Galeazzi 4, 20161 Milan, Italy.
Altomare
A
A
Cainelli
C
C
Franchi
C
C
Frigerio
E
E
Garutti
C
C
Taglioni
M
M
Altomare
G F
GF
D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D016460:Granuloma Annulare / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine