title: Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome.
abstract: The prevalence of a range of DSM-IV psychiatric disorders in a sample of 119 4-16-year-old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM-IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4-6 years) to Inattentive for the oldest group (ages 11-16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS.
authors.affiliation: Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA. o.leyfer@louisville.edu
authors.forename: Ovsanna T
authors.initials: OT
authors.lastname: Leyfer
authors.forename: Janet
authors.initials: J
authors.lastname: Woodruff-Borden
authors.forename: Bonita P
authors.initials: BP
authors.lastname: Klein-Tasman
authors.forename: Johanna S
authors.initials: JS
authors.lastname: Fricke
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Mervis
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000145:classification / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D018980:Williams Syndrome / Q000150:complications*