Pd/C-catalyzed chemoselective hydrogenation in the presence of diphenylsulfide.
[Structure: see text] A Pd/C-catalyzed chemoselective hydrogenation using diphenylsulfide as a catalyst poison has been developed. This methodology selectively hydrogenates olefin and acetylene functionalities without hydrogenolysis of aromatic carbonyls and halogens, benzyl esters, and N-Cbz protective groups.
Mori
Akinori
A
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.
Miyakawa
Yumi
Y
Ohashi
Eri
E
Haga
Tomoko
T
Maegawa
Tomohiro
T
Sajiki
Hironao
H
D000114:Acetylene / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*
D000475:Alkenes; D013440:Sulfides; D010165:Palladium; D000114:Acetylene