title: Psychological and cytokine changes in children and adolescents undergoing hematopoietic stem cell transplantation.
abstract: BACKGROUND
  Hematopoietic stem cell transplantation is a therapeutic option of a large variety of diseases. It involves several physiological and psychological changes. Investigations of mood changes in patients undergoing hematopoietic stem cell transplantation are common. There are no studies however, on the relationship between changes in mood and physiological changes in hematopoietic stem cell transplantation in children and adolescents. We investigated the correlation between anxiety, depression and serum Interleukin-1beta (IL-1beta), IL-2 and IL-6.
  
  
  METHODS
  Participants, 11 boys and 12 girls, aged 6-18 years, were administered the Children Depression Inventory (CDI) and the Spielberger State Anxiety Inventory for Children (SAIC), at four different points in time: at conditioning time when treatment is initiated (time 1 = T1), on the day of hematopoietic transplantation (T2), on the day of engraftment (T3) and a week after the engraftment (T4). At each of those times serum samples for cytokines determination were collected as well.
  
  
  RESULTS
  Up to the time of engraftment depression and anxiety were relatively high but resolved subsequently. Globally, there was a significant time effect for anxiety (p = 0.0082). Namely, scores differ between times. Depression showed a similar trend, though this trend did not reach significance (p = 0.1394). Negative correlation was found between serum IL-1beta, IL-2 and IL-6 levels and anxiety (IL-2 and IL-6) and depression scores (IL-1beta and IL-2) at T4. The complex interaction between cytokines, depression and anxiety in children and adolescents undergoing hematopoietic stem cell transplantation merits further long-term studies under natural conditions and on laboratory models.
authors.affiliation: Department of Pediatric Hematology/Oncology, The Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Dafna
authors.initials: D
authors.lastname: Munitz-Shenkar
authors.forename: Tamar
authors.initials: T
authors.lastname: Krulik
authors.forename: Chava
authors.initials: C
authors.lastname: Peretz
authors.forename: Roni
authors.initials: R
authors.lastname: Shiloh
authors.forename: Ronit
authors.initials: R
authors.lastname: Elhasid
authors.forename: Amos
authors.initials: A
authors.lastname: Toren
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000209:etiology*; D002648:Child; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics / Q000379:methods; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D016207:Cytokines