Levetiracetam pharmacokinetics in neonates at birth.
Based on blood sampling in a formula-fed pair of twins, the estimated serum half-life of levetiracetam (LEV) at birth is 16-18 h.
Allegaert
Karel
K
Neonatal Intensive Care Unit, Division of Women and Child, University Hospital Gasthuisberg, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
Lewi
Liesbeth
L
Naulaers
Gunnar
G
Lagae
Lieven
L
D000653:Amniotic Fluid / Q000737:chemistry / Q000378:metabolism; D000927:Anticonvulsants / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000188:drug therapy; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000378:metabolism*; D000077287:Levetiracetam; D008431:Maternal-Fetal Exchange; D010889:Piracetam / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy; D014427:Twins / Q000097:blood / Q000378:metabolism
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam