Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma.
The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.
Bortolin
Maria Teresa
MT
Microbiology, Immunology and Virology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Simonelli
Cecilia
C
Zanussi
Stefania
S
Pratesi
Chiara
C
Bidoli
Ettore
E
Rupolo
Maurizio
M
Berretta
Massimiliano
M
Tedeschi
Rosamaria
R
De Paoli
Paolo
P
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000187:drug effects / Q000276:immunology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001772:Blood Cell Count; D016516:CD4-CD8 Ratio; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000821:virology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D008875:Middle Aged; D011533:Proviruses / Q000187:drug effects; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D012008:Recurrence; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects
D018952:Antigens, CD34; D012367:RNA, Viral; D016179:Granulocyte Colony-Stimulating Factor