Synthesis and biological evaluation of manzamine analogues.
[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.
Winkler
Jeffrey D
JD
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. winkler@sas.upenn.edu
Londregan
Allyn T
AT
Ragains
Justin R
JR
Hamann
Mark T
MT
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry
D000962:Antimalarials; D002227:Carbazoles; C078290:manzamine A; D002738:Chloroquine