Nodular mastocytosis.
Mastocytosis refers to a group of disorders characterized by the pathologic proliferation of mast cells. We present a 70-year-old white man with a rare presentation of nodular mastocytosis, characterized by disseminated nodular lesions, myelodysplastic syndrome, and a c-kit V560G receptor mutation. The patient presented to the clinic after initial presentation 6 months earlier, with ear pruritus, associated hearing loss, and widespread rash.
Kasprowicz
Sarah
S
Department of Dermatology, Rush University Medical Center, Chicago, IL 60612, USA. sarah_kasprowicz@rush.edu
Chan
I-Ja
IJ
Wall
Daniel J
DJ
Tharp
Michael D
MD
D000368:Aged; D004423:Ear / Q000473:pathology; D034381:Hearing Loss; D006801:Humans; D008297:Male; D034701:Mastocytosis, Cutaneous / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D011537:Pruritus
D019009:Proto-Oncogene Proteins c-kit