Enhancement of in vitro growth of pathogenic bacteria by norepinephrine: importance of inoculum density and role of transferrin.
Norepinephrine is a stress hormone that enhances bacterial growth. We examined the effects of a small inoculum on the norepinephrine-induced growth of species previously reported to be unaffected by norepinephrine. The results indicated that a reduced inoculum density is essential for observing norepinephrine-induced effects. Additional studies using serum-free media suggested that transferrin plays a role in norepinephrine-induced growth.
O'Donnell
Phyllis M
PM
Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, NY 13902-6000, USA. odonnell@binghamton.edu
Aviles
Hernan
H
Lyte
Mark
M
Sonnenfeld
Gerald
G
D015169:Colony Count, Microbial; D003470:Culture Media; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity; D014168:Transferrin / Q000378:metabolism*
D003470:Culture Media; D014168:Transferrin; D009638:Norepinephrine