title: Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension.
abstract: There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p < .0001). Significant increase was also observed for MMP-9 level and activity (p < .0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. giuderosa@tin.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Derosa
authors.forename: Angela
authors.initials: A
authors.lastname: D'Angelo
authors.forename: Leonardina
authors.initials: L
authors.lastname: Ciccarelli
authors.forename: Mario N
authors.initials: MN
authors.lastname: Piccinni
authors.forename: Fabio
authors.initials: F
authors.lastname: Pricolo
authors.forename: Sibilla
authors.initials: S
authors.lastname: Salvadeo
authors.forename: Lorenza
authors.initials: L
authors.lastname: Montagna
authors.forename: Alessia
authors.initials: A
authors.lastname: Gravina
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ferrari
authors.forename: Simona
authors.initials: S
authors.lastname: Galli
authors.forename: Sonia
authors.initials: S
authors.lastname: Paniga
authors.forename: Carmine
authors.initials: C
authors.lastname: Tinelli
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology; D007249:Inflammation; D008055:Lipids / Q000097:blood; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9