Construction of evolutionary tree models for nasopharyngeal carcinoma using comparative genomic hybridization data.
Nasopharyngeal carcinoma (NPC) is a malignancy associated with remarkable racial and geographic factors. The development and progression of NPC may involve the accumulation of multiple genetic alterations over a long time. For understanding the putative order of genetic alteration in NPC tumorigenesis, we used evolutionary tree models (branching and distance-based tree models) to analyze comparative genomic hybridization (CGH) data of previously published NPC cases (n = 103). Consistent loss of 3p for both tree models was an important early event in NPC progression. Chromosome 12 gain was another important early event, and may represent a subclass different from 3p- derived subclasses of NPC. The tree models also suggested that at least two subclasses of 3p- derived NPC, one marked by 1q+, 9p-, and 13q- and the other marked by 14q-, 16q-, 9q-, and 1p-.
Shih-Hsin Wu
Lawrence
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Research Development Division, Vita Genomics Inc., 7 Fl., No. 6 Section 1 Jungshing Road, Wugu Shiang, Taipei County, 248 Taiwan. lawrence.wu@vitegenomics.com
D004273:DNA, Neoplasm / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D008957:Models, Genetic; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging / Q000145:classification; D009693:Nucleic Acid Hybridization; D014944:World Health Organization
D004273:DNA, Neoplasm