[The frequency and resistance of cytotoxin-associated (CAG-A) Helicobacter pylori strains to antibacterial agents in chronic gastritis and duodenal ulcer].
The authors of the study demonstrate that Helicobacter pylori (HP) strains with the cytoxin-associated protein Cag A are more frequent in patients suffering from duodenal ulcer (DU) or lymphocyte gastritis. DU is more severe and often displays a recurrent character in cases with persistent Cag A-positive HP strains. The authors studied the sensitivity of HP strains with the cytoxin-associated protein Cag A to various antibacterial preparations. The study shows that resistance of HP to metronidazole is found mostly among Cag A strains (58.5% of cases).
Mirodzhov
G K
GK
Ishankulova
D M
DM
Dustov
A D
AD
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D004381:Duodenal Ulcer / Q000453:epidemiology*; D005260:Female; D005756:Gastritis / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori