Effect of lipids from Erabu sea snake, Laticauda semifasciata, on plasma glucose, insulin, and adipocytokine concentrations of normal and streptozotocin-diabetic mice.
OBJECTIVE
To clarify the influence of Erabu sea snake lipid on levels of plasma insulin and adipocyte-derived hormones.


METHODS
Normal male mice (6 months) and streptozotocin-diabetic mice (a single administration, 150 mg/kg i.p.) were fed diets containing 10% fat as either lard or a mixture of 5% lard and 5% sea snake lipid for 4 months.


RESULTS
The normal mice on the sea snake lipid diet had a significantly lower plasma glucose concentration (198 +/- 16 mg/dl; 148 +/- 11 mg/dl) than those mice on the lard diet. Although plasma insulin concentrations were not influenced by the dietary fat type, leptin (10 +/- 1 ng/ml; 16 +/- 2 ng/ml) and adiponectin (18 +/- 1 mug/ml; 21 +/- 1 mug/ml) concentrations were significantly higher in the sea snake lipid group than in the lard group. However, these effects of a sea snake lipid intake were not evident in the streptozotocin-diabetic mice.


CONCLUSIONS
The results suggest that the decrease in plasma glucose following the intake of sea snake lipids could be related to a corresponding increase in leptin and adiponectin level.
Shirai
Nobuya
N
National Food Research Institute, Kannondai, Tsukuba, Ibaraki, Japan. nshinya@nfri.affrc.go.jp
Higuchi
Tomoyuki
T
Suzuki
Hiramitsu
H
Shimizu
Eiji
E
D052242:Adiponectin / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D017815:Elapidae; D005227:Fatty Acids / Q000097:blood; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D052243:Resistin / Q000097:blood
D052242:Adiponectin; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D020738:Leptin; D008055:Lipids; D052243:Resistin