Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis.
The present investigation was undertaken to explore the anti-tumor promoting activity of Rosemarinus officinalis on two-stage skin carcinogenesis, induced by a single topical application of 7, 12-dimethylbenz(a)anthracene and promoted by treatment of croton oil for 15 weeks in Swiss albino mice. Oral administration of Rosemary leaf extract at a dose of 1,000 mg/ kg b. wt. / day at pre, peri and post-initiational phases, was found to be effective in decreasing the tumor incidence (50, 41.7, 58.3%, respectively) in comparison to the control (100%). Furthermore, the cumulative number of papillomas, tumor yield and tumor burden were also found to be reduced in R. officinalis-treated animals. This was associated with significant alteration in liver lipid peroxidation and glutathione (GSH) levels.
Sancheti
Garima
G
Radiation and Cancer Biology Lab, Dept Zoology, University of Rajasthan, Jaipur, 302 004 India. garimasancheti@rediffmailcom
Goyal
Pk
P
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves; D027542:Rosmarinus; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*
D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D005978:Glutathione