Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences.
G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.
Scaria
Vinod
V
GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology CSIR, Mall Road, Delhi 110 007, India.
Hariharan
Manoj
M
Arora
Amit
A
Maiti
Souvik
S
D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D020407:Internet; D012313:RNA / Q000737:chemistry; D017422:Sequence Analysis, DNA / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
D006147:Guanine; D012313:RNA; D004247:DNA