title: Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult.
abstract: The Bcl family contains both pro and antiapoptotic proteins participating in the regulation of neuronal cell death in several pathological conditions. However, very little is known about physiological profiles of Bcl-2/Bax expression in normal brain. In this study, we examined expression profile of Bcl-2 and Bax proteins in normal pineal gland in children. The material for analysis was obtained by biopsy of pineal parenchyma during surgery of pineal cysts. All specimens were labeled immunohistochemically and analyzed by means of confocal laser scanning microscope. We found only few Bcl-2 expressing (0.7%) and no Bax-immunopositive (0.0%) pinealocytes. Bcl-2-positive cells were mature neurons, neither young ones nor glia.
authors.affiliation: Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752 Katowice, Poland. Vie@alpha.net.pl
authors.forename: Wiesław
authors.initials: W
authors.lastname: Marcol
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kotulska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Larysz-Brysz
authors.forename: Izabela
authors.initials: I
authors.lastname: Malinowska-Kołodziej
authors.forename: Marek
authors.initials: M
authors.lastname: Mandera
authors.forename: Joanna
authors.initials: J
authors.lastname: Lewin-Kowalik
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D001927:Brain Diseases / Q000473:pathology / Q000601:surgery; D002648:Child; D003560:Cysts / Q000473:pathology / Q000601:surgery; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010870:Pineal Gland / Q000166:cytology / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: C494826:BAX protein, human; D015415:Biomarkers; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein