Glucocorticosteroids in allergic inflammation: clinical benefits in otitis media with effusion.
Allergy and otitis media with effusion are often considered as comorbidities. Evidence points to a role for allergy in the pathogenesis of otitis media with effusion in reports of increased prevalence of allergy in patients with otitis media with effusion and presence of late-phase allergic-response inflammatory mediators and cytokines in the middle-ear effusion of allergic subjects. However, the exact mechanism remains unknown. Many speculations have been made, but well-controlled studies to prove the efficacy of anti-allergic medication in the treatment of otitis media with effusion are lacking. Therefore, we do not recommend the use of glucocorticosteroids in allergic patients with otitis media with effusion.
Dhooge
Ingeborg
I
Ghent University Hospital, Belgium. ingeborg.dhooge@Ugent.be
Verbruggen
Katia
K
Vandenbulcke
Liesbet
L
D018927:Anti-Asthmatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D010034:Otitis Media with Effusion / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism
D018927:Anti-Asthmatic Agents; D016207:Cytokines; D005938:Glucocorticoids