title: Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report.
abstract: Osteosclerotic myeloma is a rare plasma cell disorder often associated with a polyneuropathy. We describe a young patient with progressive polyneuropathy associated with vertebral bone marrow lesions and unusual meningeal infiltration at cauda level. The diagnosis of osteosclerotic myeloma was confirmed by bone marrow biopsy findings including the chromosome 13q14 deletion in 37% of the cells. Leptomeningeal involvement was demonstrated by spine magnetic resonance imaging with gadolinium administration and fat-suppression technique.
authors.affiliation: Department of Neuroscience, Psychiatry and Anaesthesiology, Neuroradiology Unit, University of Messina, Italy. annamazzeo@yahoo.it
authors.forename: Anna
authors.initials: A
authors.lastname: Mazzeo
authors.forename: Francesca
authors.initials: F
authors.lastname: Granata
authors.forename: Sergio
authors.initials: S
authors.lastname: Vinci
authors.forename: Caterina
authors.initials: C
authors.lastname: Musolino
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Nastasi
authors.forename: Massimo
authors.initials: M
authors.lastname: Autunno
authors.forename: Corrado
authors.initials: C
authors.lastname: Messina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vita
authors.forename: Marcello
authors.initials: M
authors.lastname: Longo
mesh_terms: D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000175:diagnosis*; D009101:Multiple Myeloma / Q000175:diagnosis*; D010026:Osteosclerosis / Q000175:diagnosis*; D016878:POEMS Syndrome / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA