Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivatives.
[Structure: see text] Under special conditions, N-phthaloyl-alpha-amino acid amides of 8-aminoquinoline can be either acetoxylated or arylated selectively at the beta-carbon. In certain cases, arylation can be effected at the gamma-carbon.
Reddy
B V Subba
BV
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Reddy
Leleti Rajender
LR
Corey
E J
EJ
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D000634:Aminoquinolines; C080436:8-aminoquinoline