title: Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
abstract: A new cyclic nonapeptide, segetalin F, has been isolated from the seeds of Vaccaria segetalis and the structure including absolute stereochemistry was elucidated by using 2D NMR and chemical means. A series of segetalins showed a vasorelaxant activity against norepinephrine (NE)-induced contractions of rat aorta.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. moritah@hoshi.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Michiko
authors.initials: M
authors.lastname: Eda
authors.forename: Toru
authors.initials: T
authors.lastname: Iizuka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Yun
authors.forename: Hideji
authors.initials: H
authors.lastname: Itokawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012639:Seeds / Q000737:chemistry; D031245:Vaccaria / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D010456:Peptides, Cyclic; D010936:Plant Extracts; C514047:segetalin F