A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells.
Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15-dependent cells characterized by high expression of the IL-2/IL-15 receptor beta (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L(lo), CD69(hi), CD43(hi), and CD127(lo)) and show a high rate of background proliferation. Cells with this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(-/-) mice. Unlike CD122(hi) CD8(+) cells, CD122(lo) MP CD8(+) cells survive poorly after transfer to MHC-I(-/-) hosts and cease to proliferate. Although distinctly different from typical antigen-specific memory cells, CD122(lo) MP CD8(+) cells closely resemble the antigen-dependent memory CD8(+) cells found in chronic viral infections.
Boyman
Onur
O
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cho
Jae-Ho
JH
Tan
Joyce T
JT
Surh
Charles D
CD
Sprent
Jonathan
J
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D055316:Cystatin C; D015891:Cystatins / Q000172:deficiency / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000502:physiology*; D007156:Immunologic Memory / Q000502:physiology*; D016130:Immunophenotyping; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism
C525031:Cst3 protein, mouse; D055316:Cystatin C; D015891:Cystatins; D015395:Histocompatibility Antigens Class I