title: Biphasic anaphylactic reaction to Ketorolac tromethamine.
abstract: Ketorolac tromethamine is a recent injectable non-steroidal anti-inflammatory drug (NSAID) with analgesic properties approved for short-term pain management. In spite of its increasing use both in adults and children, relatively few allergic-like reactions have been reported. Reactions are often severe, and a death occurred following an intramuscular injection of ketorolac.
authors.affiliation: Allergy and Clinical Immunology Unit, Azienda Ospedaliero Universitaria A. Meyer, Via L. Giordano 13, 50132 Florence, Italy. e.novembre@meyer.it
authors.forename: E
authors.initials: E
authors.lastname: Novembre
authors.forename: C
authors.initials: C
authors.lastname: Calogero
authors.forename: F
authors.initials: F
authors.lastname: Mori
authors.forename: R
authors.initials: R
authors.lastname: Bernardini
authors.forename: N
authors.initials: N
authors.lastname: Pucci
authors.forename: P
authors.initials: P
authors.lastname: Neri
authors.forename: M
authors.initials: M
authors.lastname: Bonini
authors.forename: A
authors.initials: A
authors.lastname: Vierucci
authors.forename: M
authors.initials: M
authors.lastname: De Martino
mesh_terms: D000293:Adolescent; D000707:Anaphylaxis / Q000188:drug therapy / Q000503:physiopathology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002744:Chlorpheniramine / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D020911:Ketorolac Tromethamine / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use; D012882:Skin Tests; D014581:Urticaria / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine; D020911:Ketorolac Tromethamine; D008775:Methylprednisolone