title: Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders.
abstract: Some previous studies have reported the involvement of magnesium (Mg) deficiency in children with ADHD syndrome. In this work, 40 children with clinical symptoms of ADHD were followed clinically and biologically during a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) which was set up for at least 8 weeks. Symptoms of ADHD (hyperactivity, hyperemotivity/ aggressiveness, lack of attention at school) were scored (0-4) at different times; in parallel, intraerythrocyte Mg2+ (Erc-Mg) and blood ionized Ca2+ (i-Ca) were measured. Children from the ADHD group showed significantly lower Erc-Mg values than control children (n = 36). In almost all cases of ADHD, Mg-B6 regimen for at least two months significantly modified the clinical symptoms of the disease: namely, hyperactivity and hyperemotivity/aggressiveness were reduced, school attention was improved. In parallel, the Mg-B6 regimen led to a significant increase in Erc-Mg values. When the Mg-B6 treatment was stopped, clinical symptoms of the disease reappeared in few weeks together with a decrease in Erc-Mg values. This study brings additional information about the therapeutic role of a Mg-B6 regimen in children with ADHD symptoms.
authors.affiliation: Explorations Fonctionnelles du Système Nerveux, Centre Hospitalier Universitaire Carémeau, Nîmes, France.
authors.forename: M
authors.initials: M
authors.lastname: Mousain-Bosc
authors.forename: M
authors.initials: M
authors.lastname: Roche
authors.forename: A
authors.initials: A
authors.lastname: Polge
authors.forename: D
authors.initials: D
authors.lastname: Pradal-Prat
authors.forename: J
authors.initials: J
authors.lastname: Rapin
authors.forename: J P
authors.initials: JP
authors.lastname: Bali
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D008297:Male; D009483:Neuropsychological Tests; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D025101:Vitamin B 6; D008274:Magnesium; D002118:Calcium