title: Isolated metachronous splenic metastasis from synchronous colon cancer.
abstract: BACKGROUND
  Isolated splenic metastases from colorectal cancer are very rare and there are only 13 cases reported in the English literature so far. Most cases are asymptomatic and the diagnosis is usually made by imaging studies during the evaluation of rising CEA level postoperatively.
  
  
  METHODS
  A 76-year-old man underwent an extended left hemicolectomy for synchronous colon cancers located at the left flexure and the sigmoid colon. The tumors were staged as IIIC (T3N2M0) clinically and the patient received adjuvant chemotherapy. During the first year follow-up period, the patient remained asymptomatic with normal levels of laboratory tests including CEA measurement. However, a gradually rising CEA level after the 14th postoperative month necessitated further imaging studies including computed tomography of the abdomen which revealed a mass in the spleen that was subsequently confirmed by 18FDG- PET scanning to be an isolated metastasis. The patient underwent splenectomy 17 months after his previous cancer surgery. Histological diagnosis confirmed a metastatic adenocarcinoma with no capsule invasion. After an uneventful postoperative period, the patient has been symptom-free during the one-year of follow-up with normal blood CEA levels, although he did not accept to receive any further adjuvant therapy. To the best of our knowledge, this 14th case of isolated splenic metastasis from colorectal carcinoma is also the first reported case of splenic metastasis demonstrated preoperatively by 18FDG PET-CT fusion scanning which revealed its solitary nature as well.
  
  
  CONCLUSIONS
  Isolated splenic metastasis is a rare finding in the follow-up of colorectal cancer patients and long-term survival can be achieved with splenectomy.
authors.affiliation: Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey. rgencosmanoglu@marmara.edu.tr
authors.forename: Rasim
authors.initials: R
authors.lastname: Gencosmanoglu
authors.forename: Fugen
authors.initials: F
authors.lastname: Aker
authors.forename: Gozde
authors.initials: G
authors.lastname: Kir
authors.forename: Nurdan
authors.initials: N
authors.lastname: Tozun