Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.
BACKGROUND
Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, thus ignoring the type of disease-causing mutations (dominant or recessive). In this report we present a comprehensive study of the evolutionary history of autosomal disease genes separated by mode of inheritance.


RESULTS
We examine differences in protein and coding sequence conservation between dominant and recessive human disease genes. Our analysis shows that disease genes affected by dominant mutations are more conserved than those affected by recessive mutations. This could be a consequence of the fact that recessive mutations remain hidden from selection while heterozygous. Furthermore, we employ functional annotation analysis and investigations into disease severity to support this hypothesis.


CONCLUSIONS
This study elucidates important differences between dominantly- and recessively-acting disease genes in terms of protein and DNA sequence conservation, paralogy and essentiality. We propose that the division of disease genes by mode of inheritance will enhance both understanding of the disease process and prediction of candidate disease genes in the future.
Furney
Simon J
SJ
Genome Bioinformatics Laboratory, Centre for Genomic Regulation, Universitat Pompeu Fabra, Pg, Maritim de la Barceloneta 37-49, E-08003, Barcelona, Spain. simon.furney@ucd.ie
Albà
M Mar
MM
López-Bigas
Núria
N
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D019295:Computational Biology; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005799:Genes, Dominant; D020043:Genes, Essential; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000145:classification / Q000235:genetics*; D040342:Genetic Structures; D006801:Humans; D051379:Mice; D009154:Mutation; D002679:Pan troglodytes / Q000235:genetics; D012641:Selection, Genetic; D017386:Sequence Homology, Amino Acid