title: The electrochemical oxidation of troxerutin and its sensitive determination in pharmaceutical dosage forms at PVP modified carbon paste electrode.
abstract: The voltammetric responses of troxerutin were investigated at polyvinylpyrrolidone (cross-linked) (PVP) modified carbon paste electrode (CPE) in 0.1 mol/L KCl by several electrochemical techniques. A well-defined oxidation peak was observed at about 0.97 V. Compared with poor responses of troxerutin at bare electrode that at this modified electrode has been greatly improved. It is PVP that enhances the adsorption of troxerutin to electrode surface based on their hydrophobic property. Under some optimized experimental conditions, a simple and sensitive electroanalytical method was developed for the quantitative analysis of troxerutin. A very low detection limit of 5.0 x 10(-9)mol/L was obtained for 5 min accumulation at open circuit (S/N=3). This proposed method was successfully applied to the detection of troxerutin in pharmaceutical dosage forms and satisfying results had been obtained.
authors.affiliation: Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Shengshui
authors.initials: S
authors.lastname: Hu
mesh_terms: D000327:Adsorption; D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D004304:Dosage Forms; D004563:Electrochemistry; D004566:Electrodes; D004573:Electrolytes; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011189:Potassium Chloride / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D004304:Dosage Forms; D004573:Electrolytes; D006896:Hydroxyethylrutoside; D011189:Potassium Chloride; D002244:Carbon; C005865:troxerutin; D011205:Povidone