title: An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home.
abstract: This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant.
authors.affiliation: Department of Hygiene, University of Perugia, Via del Giochetto, I-06100 Perugia, Italy. anna@unipg.it
authors.forename: A M
authors.initials: AM
authors.lastname: Iorio
authors.forename: M
authors.initials: M
authors.lastname: Neri
authors.forename: E
authors.initials: E
authors.lastname: Lepri
authors.forename: B
authors.initials: B
authors.lastname: Camilloni
authors.forename: M
authors.initials: M
authors.lastname: Basileo
authors.forename: N
authors.initials: N
authors.lastname: Sigismondi
authors.forename: C
authors.initials: C
authors.lastname: Fabiani
authors.forename: L
authors.initials: L
authors.lastname: Calzoletti
authors.forename: S
authors.initials: S
authors.lastname: Puzelli
authors.forename: I
authors.initials: I
authors.lastname: Donatelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D004196:Disease Outbreaks; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D009735:Nursing Homes; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines