title: Human chorionic gonadotropin inhibits insulin-like growth factor-binding protein-1 and prolactin in decidualized human endometrial stromal cells.
abstract: Recent data clearly show that hCG, as one of the first hormonal signals of the embryo, is involved in the modulation of endometrial receptivity in the secretory phase. Here we report a significant dose- and time-dependent inhibition of insulin-like growth factor-binding protein-1 and prolactin by hCG in human endometrial stromal cells after decidualization in vitro-findings that further underline the role of hCG in the endometrial milieu during early implantation.
authors.affiliation: Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Fluhr
authors.forename: Stefanie
authors.initials: S
authors.lastname: Krenzer
authors.forename: Margarita
authors.initials: M
authors.lastname: Deperschmidt
authors.forename: Manfred
authors.initials: M
authors.lastname: Zwirner
authors.forename: Diethelm
authors.initials: D
authors.lastname: Wallwiener
authors.forename: Peter
authors.initials: P
authors.lastname: Licht
mesh_terms: D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000235:genetics; D003656:Decidua / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011994:Recombinant Proteins / Q000008:administration & dosage; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D011994:Recombinant Proteins; D011388:Prolactin