title: Dense eosinophilic infiltration of the mucosa preceding ulcerative colitis and mimicking eosinophilic colitis: report of two cases.
abstract: There is increasing evidence about the involvement of eosinophils in the pathogenesis of inflammatory bowel disease. We report here two patients with ulcerative colitis who were initially diagnosed as eosinophilic colitis based on histopathological examination during their first attacks. They had symptomatic improvement with ketotifen and metronidazole during their first attacks. However, subsequent attacks which were histopathologically diagnosed as ulcerative colitis did not resolve with the above-mentioned treatment and necessitated a treatment with 5-ASA agents plus corticosteroids. Azathioprine also had to be added in the treatment of the second patient. Dense eosinophilic infiltration in these cases may suggest a role of eosinophils in the initiation of attacks in some ulcerative colitis patients.
authors.affiliation: Department of Gastroenterology, Istanbul University Cerrahpaşa Medical Faculty, Istanbul, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Uzunismail
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Hatemi
authors.forename: Gülen
authors.initials: G
authors.lastname: Doğusoy
authors.forename: Onat
authors.initials: O
authors.lastname: Akin
mesh_terms: D000293:Adolescent; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000473:pathology*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D007665:Ketotifen / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D018926:Anti-Allergic Agents; D000964:Antimetabolites, Antineoplastic; D005938:Glucocorticoids; D001379:Azathioprine; D007665:Ketotifen; D008775:Methylprednisolone