title: The effect of infused fat emulsions on reticuloendothelial function in the rabbit.
abstract: The effect of the infusion of different fat emulsions (Intralipid and MCT/LCT mixtures) on the reticuloendothelial function of the rabbit has been investigated. Emulsions containing 20% dispersed triglyceride were administered over 6 h to a total of 3 g/kg body weight. The extent of blockade of the reticuloendothelial system was measured using a labelled probe in the form of technetium-99m labelled albumin microspheres. Scintigraphic and blood and organ level determinations demonstrated that all emulsions caused an impairment of reticuloendoethlial function, but this was small.
authors.affiliation: Department of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Davis
authors.forename: L
authors.initials: L
authors.lastname: Illum
authors.forename: R
authors.initials: R
authors.lastname: Muller
authors.forename: F
authors.initials: F
authors.lastname: Landry
authors.forename: J
authors.initials: J
authors.lastname: Wright
authors.forename: G
authors.initials: G
authors.lastname: Harper