title: [A case of long-term survival of gastric cancer with peritoneal metastasis effectively treated by TS-1 and paclitaxel (PTX) combination therapy].
abstract: We experienced the case of a 62-year-old woman who obtained long-term survival of three years by TS-1+paclitaxel (PTX) administration for gastric cancer postoperative peritoneal metastases. We first performed total gastrectomy, and the diagnosis was T3N2M0, Stage IIIB. Next, we performed chemotherapy by postoperative 5-FU+cisplatin (CDDP) and met in ambulatory. A bowel movement aberration was found during the course at 3 years postoperatively, and close inspection revealed sigmoid colon stenosis by peritoneal metastases. After construction of an artificial anus, we started administration of TS-1+paclitaxel. Chemotherapy was continued on an outpatient basis, and at-home treatment was possible for about 26 months till symptoms aggravated. No grave adverse event occurred except for depilation of grade 1. It was thought that this long-term treatment on an outpatient basis contributed to survival.
authors.affiliation: Dept. of Surgery, Kobe Rousai Hospital.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Taichi
authors.initials: T
authors.lastname: Kanamaru
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003251:Constriction, Pathologic; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D012810:Sigmoid Diseases / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil