Immunogenicity of formaldehyde and binary ethylenimine inactivated infectious bursal disease virus in broiler chicks.
Infectious bursal disease virus (IBDV) was inactivated by two different chemicals--formaldehyde and binary ethylenimine (BEI). Formaldehyde was used at 0.1% and 0.2%, while BEI was used at concentrations of 0.001 and 0.002 mol/L. These four vaccines were tested for their efficiency in generating humoral immune response in different groups of broiler chicks. Both BEI-inactivated vaccines gave relatively higher antibody titers and were almost twice as efficient as formaldehyde-inactivated ones.
Habib
Mudasser
M
Department of Veterinary Microbiology, University of Agriculture, Faisalabad 38040, Pakistan. mudasserhabib@yahoo.com
Hussain
Iftikhar
I
Irshad
Hamid
H
Yang
Zong-zhao
ZZ
Shuai
Jiang-bing
JB
Chen
Ning
N
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001388:Aziridines / Q000494:pharmacology; D002645:Chickens; D005557:Formaldehyde / Q000494:pharmacology; D007243:Infectious bursal disease virus / Q000276:immunology*; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D001388:Aziridines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; C478655:binary ethyleneimine; D005557:Formaldehyde