Is methylglyoxal a causative factor for hypertension development?
Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.
Wu
Lingyun
L
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. liw070@duke.usask.ca
D000818:Animals; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006984:Hypertrophy; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology; D016328:NF-kappa B / Q000378:metabolism; D011765:Pyruvaldehyde / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D016328:NF-kappa B; D017382:Reactive Oxygen Species; D011765:Pyruvaldehyde; D020928:Mitogen-Activated Protein Kinases; D005947:Glucose