[Calcineurin inhibitors for topical therapy in psoriasis].
There are numerous possibilities for specific antiinflammatory therapy of psoriasis. One option is the use of calcineurin inhibitors. To date, only systemic administration of cyclosporine A is approved for this indication. Nonetheless cyclosporine A, tacrolimus and pimecrolimus can all be classed as effective anti-inflammatory agents for the therapy of psoriasis. Unfortunately, the vehicles currently available do not insure adequate topical delivery of these substances. Clinical efficacy of the preparations can be proven only when additional penetration-promoting measures are used or penetration-facilitating conditions exist. The entire group can be expected to play a greater role in the topical therapy of psoriasis if advances in vehicles and delivery systems are made.
Wohlrab
J
J
Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Kromayer-Strasse 5, 06097, Halle. johannes.wohlrab@medizin.uni-halle.de
D000287:Administration, Topical; D065095:Calcineurin Inhibitors; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D016207:Cytokines / Q000037:antagonists & inhibitors; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D005786:Gene Expression Regulation / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics; D008213:Lymphocyte Activation / Q000187:drug effects / Q000235:genetics; D008407:Mast Cells / Q000187:drug effects; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives
D065095:Calcineurin Inhibitors; D016207:Cytokines; D003879:Dermatologic Agents; D007376:Interleukin-2; C117268:pimecrolimus; D016572:Cyclosporine; D016559:Tacrolimus