One-pot transformation of trichloroacetamide into readily deprotectable carbamates.
[Structure: see text] A trichloroacetamide group was converted to an isocyanate, which was in situ captured by a variety of alcohols in the presence of CuCl and n-BuN4Cl to afford the corresponding carbamates. The scope and limitation of this transformation are also described.
Nishikawa
Toshio
T
Laboratory of Organic Chemistry, School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. nisikawa@agr.nagoya-u.ac.jp
Urabe
Daisuke
D
Tomita
Miho
M
Tsujimoto
Takashi
T
Iwabuchi
Tomoko
T
Isobe
Minoru
M