title: Autonoetic consciousness in Alzheimer's disease: neuropsychological and PET findings using an episodic learning and recognition task.
abstract: OBJECTIVE
  This study aims to map in patients with mild Alzheimer's disease (AD) the correlations between resting-state brain glucose utilization measured by FDG-PET and scores reflecting autonoetic consciousness in an episodic learning and recognition task.
  
  
  METHODS
  Autonoetic consciousness, that gives a subject the conscious feeling to mentally travelling back in time to relive an event, was assessed using the Remember/Know (R/K) paradigm.
  
  
  RESULTS
  AD patients provided less R responses (reflecting autonoetic consciousness) and more K ones (indicating the involvement of noetic consciousness) than healthy controls. Correct recognitions associated with a R response correlated with the metabolism of frontal areas bilaterally whereas those associated with a K response mainly correlated with the metabolism of left parahippocampal gyrus and lateral temporal cortex.
  
  
  CONCLUSIONS
  These data show that recollection is impaired in AD and recognition is more based on a feeling of familiarity than in controls. In addition, the findings of our correlative approach indicate that the impairment of episodic memory is mainly subserved by the dysfunction of frontal areas and of the hippocampal region.
authors.affiliation: Inserm-EPHE-Université de Caen E0218 and GIP Cyceron, Laboratoire de Neuropsychologie, CHU Avenue Côte de Nacre, 14033 CAEN cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Rauchs
authors.forename: Pascale
authors.initials: P
authors.lastname: Piolino
authors.forename: Florence
authors.initials: F
authors.lastname: Mézenge
authors.forename: Brigitte
authors.initials: B
authors.lastname: Landeau
authors.forename: Catherine
authors.initials: C
authors.lastname: Lalevée
authors.forename: Alice
authors.initials: A
authors.lastname: Pélerin
authors.forename: Fausto
authors.initials: F
authors.lastname: Viader
authors.forename: Vincent
authors.initials: V
authors.lastname: de la Sayette
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D003243:Consciousness / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D013223:Statistics as Topic; D018709:Statistics, Nonparametric
chemical_list: D019788:Fluorodeoxyglucose F18