Synthesis and biological evaluation of isomeric derivatives of naturally occurring spatozoate.
An isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b-2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. Compound 2g was found to be the most potent cytotoxic agent with a LD50 = 8.98 microg/ml. In a bactericidal assay the compounds showed a broad spectrum of activities. Compound 2a has a very promising fungicidal activity against Microsporum canis.
Hayat
Safdar
S
Institut für Organische Chemie der Universität Tübingen, Germany.
Atta-ur-Rahman
Choudhary
Muhammad Iqbal
MI
Khan
Khalid Mohammed
KM
Perveen
Shahnaz
S
Shah
Syed Tasadaque Ali
ST
Anwar
Awais
A
Anwar
M Usman
MU
Bayer
Ernst
E
Voelter
Wolfgang
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001156:Artemia; D001419:Bacteria / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D000459:Phaeophyceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D007202:Indicators and Reagents; C512631:spatozoate