title: Clinical application of a OneDose MOSFET for skin dose measurements during internal mammary chain irradiation with high dose rate brachytherapy in carcinoma of the breast.
abstract: In our earlier study, we experimentally evaluated the characteristics of a newly designed metal oxide semiconductor field effect transistor (MOSFET) OneDose in-vivo dosimetry system for Ir-192 (380 keV) energy and the results were compared with thermoluminescent dosimeters (TLDs). We have now extended the same study to the clinical application of this MOSFET as an in-vivo dosimetry system. The MOSFET was used during high dose rate brachytherapy (HDRBT) of internal mammary chain (IMC) irradiation for a carcinoma of the breast. The aim of this study was to measure the skin dose during IMC irradiation with a MOSFET and a TLD and compare it with the calculated dose with a treatment planning system (TPS). The skin dose was measured for ten patients. All the patients' treatment was planned on a PLATO treatment planning system. TLD measurements were performed to compare the accuracy of the measured results from the MOSFET. The mean doses measured with the MOSFET and the TLD were identical (0.5392 Gy, 15.85% of the prescribed dose). The mean dose was overestimated by the TPS and was 0.5923 Gy (17.42% of the prescribed dose). The TPS overestimated the skin dose by 9% as verified by the MOSFET and TLD. The MOSFET provides adequate in-vivo dosimetry for HDRBT. Immediate readout after irradiation, small size, permanent storage of dose and ease of use make the MOSFET a viable alternative for TLDs.
authors.affiliation: Department of Medical Physics, Tata Memorial Hospital, Parel, Mumbai 400 012, India.
authors.forename: Rajesh A
authors.initials: RA
authors.lastname: Kinhikar
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Sharma
authors.forename: Chandrashekhar M
authors.initials: CM
authors.lastname: Tambe
authors.forename: Umesh M
authors.initials: UM
authors.lastname: Mahantshetty
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sarin
authors.forename: Deepak D
authors.initials: DD
authors.lastname: Deshpande
authors.forename: Shyam K
authors.initials: SK
authors.lastname: Shrivastava
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000528:radiation effects*; D009362:Neoplasm Metastasis; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D012666:Semiconductors; D012867:Skin / Q000528:radiation effects*; D013819:Thermoluminescent Dosimetry; D014173:Transistors, Electronic