Molecular imaging strategies for drug discovery and development.
Recent advances in non-invasive molecular imaging provide exciting opportunities for discovery, validation and development of novel therapeutics. As the arsenal of detection devices and strategies, injectable probes, genetically encoded reporters and animal models rapidly expands, molecular imaging is becoming indispensable for drug discovery and development. Not only do such strategies reduce the time, cost and workload associated with conventional destructive end-point assays, but they also enable spatial and temporal monitoring of in vivo gene expression, signaling pathways, biochemical reactions and targets as they relate to the pharmacokinetics and pharmacodynamics of novel drugs.
Gross
Shimon
S
Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and Pharmacology, Washington University Medical School, Saint Louis, MO 63110, USA.
Piwnica-Worms
David
D
D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D017930:Genes, Reporter; D006801:Humans; D051379:Mice; D015335:Molecular Probes / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics
D015335:Molecular Probes; D004364:Pharmaceutical Preparations