title: Tizanidine distribution in a postmortem case.
abstract: The case of a 57-year-old white female who was found deceased at home by her husband is presented. A suicide note was found at the scene. No remarkable findings were observed at autopsy. Comprehensive toxicological analysis of the heart blood identified ethanol (0.16 g/dL), diazepam (1.1 mg/L), and tizanidine (2.3 mg/L). Blood concentrations of tizanidine following therapeutic use do not exceed 0.025 mg/L. The medical examiner ruled that the cause of death was combined ethanol and multiple drug intoxication, and the manner of death was suicide.
authors.affiliation: Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Bldg. 102, Rockville, Maryland 20850, USA.
authors.forename: Jason H
authors.initials: JH
authors.lastname: Sklerov
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Cox
authors.forename: Karla A
authors.initials: KA
authors.lastname: Moore
authors.forename: Barry
authors.initials: B
authors.lastname: Levine
authors.forename: David
authors.initials: D
authors.lastname: Fowler
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000097:blood / Q000506:poisoning*; D001646:Bile / Q000737:chemistry; D003000:Clonidine / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D004347:Drug Interactions; D062787:Drug Overdose; D000431:Ethanol / Q000506:poisoning*; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008099:Liver / Q000737:chemistry; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000097:blood / Q000506:poisoning*; D013405:Suicide
chemical_list: D000316:Adrenergic alpha-Agonists; D009125:Muscle Relaxants, Central; D000431:Ethanol; C023754:tizanidine; D003000:Clonidine