title: Effect of transcranial magnetic stimulation on oxidative stress induced by 3-nitropropionic acid in cortical synaptosomes.
abstract: This study evaluates the effect of transcranial magnetic stimulation (TMS; 60 Hz and 0.7 mT) treatment on 3-nitropropionic acid (20 mg/kg i.p./day for 4 days)-induced oxidative stress in cortical synaptosomes of Wistar rats. The oxidative derangement was confirmed by a high level of lipid peroxidation products and protein carbonyls, together with a decreased in reduced glutathione (GSH) content, catalase and GSH-peroxidase (GSH-Px) activities. Additionally, it was observed a reduction in succinate dehydrogenase (SDH) activity. All changes were partially prevented or reversed by administration of TMS. These results show that TMS reduces oxidative stress in cortical synaptosomes, and suggest that TMS may protect neuronal and maintain synaptic integrity.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Spain. fm2tufii@uco.es
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: Pedro
authors.initials: P
authors.lastname: Montilla
authors.forename: M
authors.initials: M
authors.lastname: del Carmen Muñoz
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Medina
authors.forename: René
authors.initials: R
authors.lastname: Drucker-Colín
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology; D008297:Male; D009574:Nitro Compounds / Q000494:pharmacology*; D018384:Oxidative Stress; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects*; D050781:Transcranial Magnetic Stimulation
chemical_list: D015415:Biomarkers; D003292:Convulsants; D009574:Nitro Compounds; D011422:Propionates; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid