title: Transmission of new bovine prion to mice.
abstract: We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrP(res). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrP(res) molecular features distinct from BSE.
authors.affiliation: Unité Agents Transmissibles Non Conventionnels, Agence Française de Sécurité Sanitaire des Aliments, Lyon, France. t.baron@lyon.afssa.fr
authors.forename: Thierry G M
authors.initials: TG
authors.lastname: Baron
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Biacabe
authors.forename: Anna
authors.initials: A
authors.lastname: Bencsik
authors.forename: Jan P M
authors.initials: JP
authors.lastname: Langeveld
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002417:Cattle; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D017096:Prion Diseases / Q000635:transmission*; D011328:Prions / Q000472:pathogenicity*
chemical_list: D011328:Prions