[DNA methylation: an epigenetic mechanism for tumorigenesis].
DNA methylation is a kind of epigenetic modification in human genome. Both hypermethylation of tumor suppressor gene or DNA repair gene and hypomethylation of repetitious DNA are closely related to different kinds of tumors. Loss of imprinting can also cause tumorigenesis. The recent study confirmed that the level of DNA methylation in genome was not only affected by DNA methyltransferase(DNMT), but also by other factors such as histone modification, diet and environment and RNA interference, etc. DNA methylation has an important role in transcriptional regulation, together with histone modification and chromatin remodeling.
Zhang
Li-Li
LL
Capital Institute of Pediatrics, Beijing 100020, China. zhanglili.cip@126.com
Wu
Jian-Xin
JX
D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009385:Neoplastic Processes; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
D025521:Tumor Suppressor Proteins