Modulation of complement activity in vitro and in vivo by Yersinia wild and mutant strains.
The ability of released proteins (Yops) and surface lipopolysaccharides (LPS) from the wild-type strain Yersinia enterocolitica 8081-L2, serotype 0:8 to influence the complement activity was determined. Yops and LPS from wild-type and mutant strains showed different ability to affect the classical pathway (CP) functional complement activity in vitro. The serum CP activity was inhibited during the infection induced with six Y. enterocolitica and three Y. pseudotuberculosis strains in rabbits. The changed complement activity might be of importance for the course of Yersinia infections.
Yordanov
M
M
Department of Immunology, Institute of Microbiology, Sofia, Bulgaria. martin@microbio.bas.bg
Golkocheva
E
E
Najdenski
H
H
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D015941:Complement Hemolytic Activity Assay; D051056:Complement Inactivating Agents / Q000276:immunology; D003171:Complement Pathway, Classical / Q000276:immunology*; D004195:Disease Models, Animal; D008070:Lipopolysaccharides / Q000276:immunology*; D011817:Rabbits; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology*; D015011:Yersinia pseudotuberculosis / Q000276:immunology*; D015012:Yersinia pseudotuberculosis Infections / Q000276:immunology
D001425:Bacterial Outer Membrane Proteins; D051056:Complement Inactivating Agents; D008070:Lipopolysaccharides