Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex.
Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.
Duffy
Kevin R
KR
Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. kevin.duffy@dal.ca
Murphy
Kathryn M
KM
Frosch
Matthew P
MP
Livingstone
Margaret S
MS
D000369:Aged, 80 and over; D001766:Blindness / Q000378:metabolism* / Q000473:pathology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D015353:Eye Enucleation; D005260:Female; D005829:Geniculate Bodies / Q000166:cytology / Q000378:metabolism; D006801:Humans; D016900:Neurofilament Proteins / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D009900:Optic Nerve / Q000166:cytology / Q000378:metabolism; D015349:Vision, Monocular / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism*; D014795:Visual Pathways / Q000166:cytology / Q000378:metabolism
D016900:Neurofilament Proteins; D003576:Electron Transport Complex IV