Long-term sensitization training primes Aplysia for further learning.
Repetitive, unilateral stimulation of Aplysia induces long-term sensitization (LTS) of ipsilaterally elicited siphon-withdrawal responses. Whereas some morphological effects of training appear only on ipsilateral sensory neurons, others appear bilaterally. We tested the possibility that contralateral morphological modifications may have functional significance. Therefore, we examined whether LTS training primes subsequent sensitization. Twenty-four hours after LTS training the effects of brief shock treatment (BST) were examined. BST failed to sensitize animals that had previously received either 4-d control treatment or 4-d ipsilateral LTS training. In contrast, BST did sensitize animals that had previously received 4-d contralateral LTS training, suggesting the presence of a latent trace that primes the animal for further learning.
Antzoulatos
Evangelos G
EG
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, 77030, USA.
Wainwright
Marcy L
ML
Cleary
Leonard J
LJ
Byrne
John H
JH
D000818:Animals; D001048:Aplysia / Q000502:physiology*; D007839:Functional Laterality; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D013997:Time Factors