Perinatal/postnatal study of D-003, a mixture of long-chain fatty acids, in rats.
D-003 is a mixture of long-chain fatty acids isolated and purified from sugar cane wax with cholesterol-lowering and antiplatelet effects. In order to further characterize the developmental toxicity during the treatment period from late gestation up to weaning of the offspring, pregnant females received 0 (control), 500, and 1,000 mg/kg/day D-003 daily by oral gavage beginning at day 15 of pregnancy and through gestation until day 21 postpartum. Maternal clinical signs, body weight, and food intake were measured at regular intervals during gestation and lactation. Live pups were weighed, sexed, and examined for developmental signs. One female and male of each litter were randomly selected to evaluate the reproductive potential. There were no spontaneous or dose-related maternal deaths during the course of this study. The general health and behavioral condition of offspring was good in all groups. No significant differences among groups were found in comparisons of litter size, survival through the weaning period, sex ratio, and male and female weights. This peri- and postnatal study conducted with D-003 in rats indicated that treatment of the dam during late gestation and lactation did not show adversely effects on reproductive performance or fetal development over two generations.
Rodríguez
M D
MD
Centre of Natural Products, National Centre for Scientific Research, Cubanacán, Havana, Cuba.
González
J E
JE
León
E F
EF
Gutiérrez
A
A
Marrero
G
G
Gámez
R
R
García
H
H
Goicochea
E
E
Rodríguez
Y
Y
Gómez
A
A
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D005227:Fatty Acids / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005865:Gestational Age; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D014886:Weaning
C418063:D-003 sugarcane wax acid mixture; D005227:Fatty Acids