Microbiological transformation of two labdane diterpenes, the main constituents of Madia species, by two fungi.
Microbial transformation of 13R,14R,15-trihydroxylabd-7-ene (5) and 13R,14R,15-trihydroxylabd-8(17)-ene (6) by the fungus Debaryomyces hansenii gave 1 (13R,14R,15-trihydroxy-6-oxolabd-8-ene) and 3 (7alpha,13R,14R,15-tetrahydroxy-labd-8(17)-ene), respectively. While, microbial transformation of 5 by Aspergillus niger afforded 2 (3beta,13R,14R,15-tetrahydroxy-labd-7-ene), and 13R,14R,15-trihydroxylabd-8,17-ene (6) gave 3 and 4 (3R,14R,15-3-oxotetrahydroxy-labd-7-ene). The structures of the new compounds, 1 and 2, were assigned by 1D and 2D high-field NMR spectroscopic methods. Antimicrobial activity of these compounds were tested and their MIC were determined.
Haridy
Mamdouh S A
MS
Department of Botany, Faculty of Science, El-Minia University, El-Minia 61519, Egypt.
Ahmed
Ahmed A
AA
Doe
Matsumi
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001234:Aspergillus niger / Q000378:metabolism*; D019659:Asteraceae / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D001409:Bacillus cereus / Q000187:drug effects; D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D004718:Saccharomycetales / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004224:Diterpenes