title: Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms--report of three cases.
abstract: We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau-Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in slow wave sleep (ESES). The third patient has a dominantly unilateral thalamic tumor and epilepsy that mimics juvenile myoclonic epilepsy. All the patients have a lesion located in the inferior-medial-posterior part of the thalamus. The role of some thalamic and subthalamic nuclei in the generalized spike-wave electrical pattern patophysiology is discussed, with emphasis on the possible role of the inhibitory system from the zona incerta.
authors.affiliation: National Institute of Psychiatry and Neurology, Huvösvölgyi út 116, 1021 Budapest, Hungary. kelemen@opni.hu
authors.forename: Anna
authors.initials: A
authors.lastname: Kelemen
authors.forename: Péter
authors.initials: P
authors.lastname: Barsi
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Gyorsok
authors.forename: Judit
authors.initials: J
authors.lastname: Sarac
authors.forename: Anna
authors.initials: A
authors.lastname: Szucs
authors.forename: Péter
authors.initials: P
authors.lastname: Halász
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012890:Sleep / Q000502:physiology; D013226:Status Epilepticus / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000473:pathology*