[The relationship between oxidized form glutathione, coenzyme II and carotid artery atherosclerosis].
OBJECTIVE
To explore the relationship between plasma redox status and atherosclerosis.


METHODS
IVUS was performed in common carotid in the neck of 167 patients with heart diseases. Patients were divided into three groups: plaque-forming group (A, n = 79), intima-thickening group (B, n = 52) and control group (C, n = 36). Plasma glutathione (reduced form GSH and oxidized form GSSG), nicotinamide adenine dinucleotide phosphate (reduced form NADPH and oxidized form NADP(+)), oxidized low density lipoprotein (ox-LDL) and malondialdehyde (MDA) were measured in all patients. The GSH/GSSG and NADPH/NADP(+) redox potential were calculated according to Nernst equation, and correlation analysis performed.


RESULTS
GSH and GSH/GSSG gradually reduced and GSH/GSSG redox potential gradually increased in proportion to the thickening of artery intima (from Group C to Group A, P < 0.05). Similar but milder results were shown for NADPH and NADPH/NADP(+) redox status. The products of oxidative stress ox-LDL and MDA also increased significantly (P < 0.05) in proportion to the thickening of artery intima. GSH/GSSG redox potential is positively correlated to ox-LDL (P < 0.05). The redox status shifted to oxidizing direction in proportion to the intima thickness.


CONCLUSIONS
The imbalance of plasma redox status deviating to oxidation might be implicated in oxidized injury of lipid, intima thickening and atherosclerosis progress.
Huang
Yan-sheng
YS
Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Wang
Shu-ren
SR
Zhi
Yan-fang
YF
Xu
Bo-shi
BS
Sun
Lin
L
Wu
Yu
Y
Lu
Jian-min
JM
Dai
Fu-min
FM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D019803:Glutathione Disulfide / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009249:NADP / Q000097:blood*; D010084:Oxidation-Reduction
D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D009249:NADP; D019803:Glutathione Disulfide