Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
Spiecker
Martin
M
Department of Medicine II, St. Josef-Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.
Liao
Jamesk
J
D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000235:genetics; D015777:Eicosanoids / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010105:Oxygenases / Q000096:biosynthesis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
C000717350:CYP2J2 protein, human; D015777:Eicosanoids; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D000090762:Cytochrome P-450 CYP2J2