Evaluation of cytotoxic potential of latex of Calotropis procera and podophyllotoxin in Allium cepa root model.
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyprohcptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.
Sehgal
R
R
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029, India.
Roy
S
S
Kumar
V L
VL
D031107:Calotropis / Q000737:chemistry; D003603:Cytotoxins / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007840:Latex / Q000302:isolation & purification / Q000494:pharmacology*; D018519:Meristem / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D008938:Mitosis / Q000187:drug effects; D019697:Onions / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D018517:Plant Roots / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D011034:Podophyllotoxin / Q000494:pharmacology*
D003603:Cytotoxins; D007840:Latex; D011034:Podophyllotoxin