Human chorionic gonadotropin inhibits insulin-like growth factor-binding protein-1 and prolactin in decidualized human endometrial stromal cells.
Recent data clearly show that hCG, as one of the first hormonal signals of the embryo, is involved in the modulation of endometrial receptivity in the secretory phase. Here we report a significant dose- and time-dependent inhibition of insulin-like growth factor-binding protein-1 and prolactin by hCG in human endometrial stromal cells after decidualization in vitro-findings that further underline the role of hCG in the endometrial milieu during early implantation.
Fluhr
Herbert
H
Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany.
Krenzer
Stefanie
S
Deperschmidt
Margarita
M
Zwirner
Manfred
M
Wallwiener
Diethelm
D
Licht
Peter
P
D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000235:genetics; D003656:Decidua / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011994:Recombinant Proteins / Q000008:administration & dosage; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism
D006063:Chorionic Gonadotropin; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D011994:Recombinant Proteins; D011388:Prolactin