Adjuvant effect of Bacillus firmus in intranasal immunization of guinea pigs with inactivated type B infuenza virus.
Intranasal immunization of guinea pigs with inactivated type B influenza virus plus inactivated Bacillus firmus as an adjuvant compared to the virus alone yields higher titers of serum hemagglutination-inhibiting antibodies and virus-neutralizing antibodies. This phenomenon could be useful in standard serology, especially in the preparation of immune sera against highly pathogenic strains for in vitro diagnosis.
Havlícková
M
M
National Institute of Public Health, Centre of Epidemiology and Microbiology, 100 42 Prague, Czechia. nflucprg@szu.cz
Prokesová
L
L
Zanvit
P
P
Tácner
J
J
Limberková
R
R
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001407:Bacillus / Q000276:immunology*; D006168:Guinea Pigs; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods; D014611:Vaccination / Q000379:methods*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines