Proteins involved in binding and cellular uptake of nucleic acids.
The study of mechanisms of nucleic acid transport across the cell membrane is valuable both for understanding the biological function of extracellular nucleic acids and the practical use of nucleic acids in gene therapy. It has been clearly demonstrated that cell surface proteins are necessary for transport of nucleic acids into cells. A large amount of data has now been accumulated about the proteins that participate in nucleic acid transport. The methods for revealing and identification of these proteins, possible mechanisms of protein-mediated transport of nucleic acids, and cellular functions of these proteins are described.
Chelobanov
B P
BP
Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, 630117, Russia. chelobanov@soramn.ru
Laktionov
P P
PP
Vlasov
V V
VV
D000818:Animals; D001693:Biological Transport, Active; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism*; D034443:RNA Transport
D004268:DNA-Binding Proteins; D009696:Nucleic Acids