title: Convexity, Jensen's inequality and benefits of noisy mechanical ventilation.
abstract: Mechanical ventilators breathe for you when you cannot or when your lungs are too sick to do their job. Most ventilators monotonously deliver the same-sized breaths, like clockwork; however, healthy people do not breathe this way. This has led to the development of a biologically variable ventilator--one that incorporates noise. There are indications that such a noisy ventilator may be beneficial for patients with very sick lungs. In this paper we use a probabilistic argument, based on Jensen's inequality, to identify the circumstances in which the addition of noise may be beneficial and, equally important, the circumstances in which it may not be beneficial. Using the local convexity of the relationship between airway pressure and tidal volume in the lung, we show that the addition of noise at low volume or low pressure results in higher mean volume (at the same mean pressure) or lower mean pressure (at the same mean volume). The consequence is enhanced gas exchange or less stress on the lungs, both clinically desirable. The argument has implications for other life support devices, such as cardiopulmonary bypass pumps. This paper illustrates the benefits of research that takes place at the interface between mathematics and medicine.
authors.affiliation: Department of Statistics & Institute of Industrial Mathematical Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3 2N2. john_brewster@umanitoba.ca
authors.forename: John F
authors.initials: JF
authors.lastname: Brewster
authors.forename: M Ruth
authors.initials: MR
authors.lastname: Graham
authors.forename: W Alan C
authors.initials: WA
authors.lastname: Mutch
mesh_terms: D000403:Airway Resistance; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000503:physiopathology* / Q000628:therapy*; D008954:Models, Biological; D015233:Models, Statistical; D011312:Pressure; D012121:Respiration, Artificial / Q000379:methods*; D013269:Stochastic Processes; D013813:Therapy, Computer-Assisted / Q000379:methods*; D013990:Tidal Volume; D016896:Treatment Outcome