[Plasma platinum concentration and anti-tumor effects after intra-arterial infusion of lipiodol-CDDP suspension evaluation with VX 2 rabbit liver cancer model and 7.0 Tesla MRI system].
To evaluate the usefulness of combination chemotherapy with cisplatin powder, which was newly designed for intra-arterial infusion (IA CALL) and lipiodol, for the VX 2 liver cancer model of the rabbit, sequential change of the plasma platinum concentration within the first 24 hours, as well as the tissue platinum concentration at 24 hours was measured after intra-arterial infusion of IA CALL. The infused materials were either IA CALL alone (C) or the combination of lipiodol+IA CALL (CL). In addition,the reduction rate of the VX 2 tumor was calculated among four therapeutic groups (C, CL, lipiodol alone (L), and saline alone (S)) after one week of intra-arterial infusion on the basis of 7.0 Tesla MR images. Total plasma platinum concentrations within the first 24 hours were kept low in group CL. No increase in the tissue platinum concentration in group CL was observed. On the other hand, the tumor reduction rate tended to be higher in group CL (group CL>group L=group C>group S). These results suggested that the intra-arterial infusion of IA CALL with lipiodol is more effective than that of IA CALL alone.
Sonoda
Akinaga
A
Dept. of Radiology, Shiga University of Medical Science.
Nitta
Norihisa
N
Ohta
Shinichi
S
Itoh
Ryuta
R
Takahashi
Masashi
M
Murata
Kiyoshi
K
Morikawa
Shigehiro
S
Inubushi
Toshiro
T
Miyagawa
Yoshihiro
Y
Takamori
Michie
M
Oonaka
Yasuo
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009368:Neoplasm Transplantation; D010984:Platinum / Q000097:blood*; D011817:Rabbits
D000970:Antineoplastic Agents; D010984:Platinum; D007459:Iodized Oil; D002945:Cisplatin