title: Atrial myxomas: pathologic types, tumor location, and presenting symptoms.
abstract: BACKGROUND
  Atrial myxoma is the most common cardiac neoplasm. Although not widely reported, two anatomic types have been observed: solid and papillary. We examined whether differences in gross or microscopic appearance and location correlated with symptomatology, specifically congestive heart failure (CHF), neurologic symptoms, and embolic events.
  
  
  METHODS
  We performed a retrospective review of atrial myxomas removed from 1972 to 2002, recording the clinical presentation, diagnostic modality, tumor location, gross, and microscopic features for each patient. Twenty-six patients (16 females and 10 males) had atrial myxomas excised. Two patients (one female and one male) were excluded due to unavailable pathologic slides.
  
  
  RESULTS
  In 24 patients there were 15 solid and 9 papillary tumors. CHF was more prevalent in solid myxomas, while neurologic symptoms and embolic events were more common in papillary tumors. Tumor location further correlated with presenting symptoms. Ninety-two percent of patients presenting with CHF had tumors attached to the atrial septum. Extraseptal myxomas more frequently presented with neurologic (80% vs. 29%) and embolic features (50% vs. 25%). All patients exhibiting clefted tumor surface had a history of embolization. A higher percentage of solid myxomas (93%) showed hemorrhage within the tumor than with papillary (56%).
  
  
  CONCLUSIONS
  CHF was more common with solid myxomas, and neurologic and embolization events were more common in the papillary type. Septal tumor location showed strong association with CHF, while extraseptal location correlated with neurologic events. We speculate that the various gross and microscopic patterns reflect secondary changes within these neoplasms over the course of their natural history.
authors.affiliation: State University of New York Upstate Medical University, Department of Cardiac Surgery, Syracuse, NY 13215, USA. swartzm@upstate.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Swartz
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Lutz
authors.forename: Vishal S
authors.initials: VS
authors.lastname: Chandan
authors.forename: Steve
authors.initials: S
authors.lastname: Landas
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Fink
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures; D005260:Female; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology; D006338:Heart Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D020766:Intracranial Embolism / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009518:New York; D015995:Prevalence; D012189:Retrospective Studies