title: Heterogeneous dopamine neurochemistry in the striatum: the fountain-drain matrix.
abstract: In contrast to the relatively high attention paid to the structural heterogeneity of striatal dopamine (DA) innervation, little attention has been focused on the possible striatal heterogeneity for release and uptake of DA. By using amperometric methods, we found striatal regions showing a DA decrease during the medial forebrain bundle stimulation (drain areas) near to other zones that showed an increase in DA concentration (fountain areas). Both areas were intermixed to form a tridimensional matrix to regulate DA concentration throughout the striatum (fountain-drain matrix). The response to electrical stimuli of different amplitudes and durations and to different drugs (alpha-methyl-l-tyrosine, cocaine, gamma-butyrolactone, and haloperidol) suggests that regional differences for both DA release/DA uptake and DA cell firing autoregulation are behind the striatal fountain-drain matrix. The high diversity of DA activity observed in the striatum is a new framework for analyzing experimental and clinical phenomena.
authors.affiliation: Departamento de Fisiologia, Facultad de Medicina, Universidad de La Laguna, 38320 Tenerife, Canary Islands, Spain. mrdiaz@ull.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Ingrid
authors.initials: I
authors.lastname: Morales
authors.forename: Isabel
authors.initials: I
authors.lastname: Gomez
authors.forename: Sergio
authors.initials: S
authors.lastname: Gonzalez
authors.forename: Tomas
authors.initials: T
authors.lastname: Gonzalez-Hernandez
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Gonzalez-Mora
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004563:Electrochemistry; D006220:Haloperidol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
chemical_list: D014446:Tyrosine 3-Monooxygenase; D003042:Cocaine; D006220:Haloperidol; D004298:Dopamine