Kimura's disease with generalized lymphadenopathy demonstrated by positron emission tomography scan.
Kimura's disease is a chronic inflammatory disorder that occurs mainly in Asian patients. Most imaging studies focus on the loco-regional involvement of this disorder. Images of the whole body fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan have not been reported in the literature before. The possibility of lymphoid clonality is also discussed frequently despite its clinically benign course. We present a patient of Kimura's disease initially assessed by whole body 18F-FDG PET study and proved by pathologic findings. 18F-FDG-PET scan showed diffusely intense uptake in the neck, axillary, pelvic and inguinal nodal regions bilaterally, as well as in the mediastinal, celiac region. The flow cytometric analysis of lymph node tissue confirmed the absence of clonality. The image of 18F-FDG-PET in Kimura's disease can closely resemble that seen in neoplastic disorders such as lymphoma or metastatic lymphadenopathy. It should be taken into consideration as a differential diagnosis for a generalized lymphadenopathy.
Wang
Tso-Fu
TF
Division of Oncology and Hematology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan, ROC.
Liu
Shu-Hsin
SH
Kao
Chih-Hao K
CH
Chu
Sung-Chao
SC
Kao
Ruey-Ho
RH
Li
Chi-Cheng
CC
D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy / Q000379:methods; D005260:Female; D005434:Flow Cytometry; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D009333:Neck; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18