Are mouse telomeres going to pot?
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length. In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities.
Baumann
Peter
P
Stowers Institute for Medical Research, Kansas City, MO 64110, USA. peb@stowers-institute.org
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D051379:Mice; D000089804:Shelterin Complex; D015398:Signal Transduction / Q000235:genetics; D016615:Telomere / Q000235:genetics*; D034501:Telomere-Binding Proteins
D004268:DNA-Binding Proteins; C507326:POT1 protein, mouse; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D004247:DNA