The neural basis of interindividual variability in inhibitory efficiency after sleep deprivation.
Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent of decline in this executive function varies across individuals. Here, we used functional magnetic resonance imaging to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency. Participants performed a go/no-go task after normal sleep and after 24 h of total sleep deprivation. Regardless of the extent of change in inhibitory efficiency, sleep deprivation lowered go/no-go sustained, task-related activation of the ventral and anterior prefrontal (PFC) regions bilaterally. However, individuals better able to maintain inhibitory efficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness. These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined.
Chuah
Y M Lisa
YM
Cognitive Neuroscience Laboratory, Singapore Health Services, Singapore, 169611.
Venkatraman
Vinod
V
Dinges
David F
DF
Chee
Michael W L
MW
D000328:Adult; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012146:Rest / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology*; D014851:Wakefulness / Q000502:physiology