Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.
Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed. Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.
Kardaun
Sylvia H
SH
Department of Dermatology, University Medical Center Groningen, University of Groningen, The Netherlands. s.h.kardaun@derm.umcg.nl
de Monchy
Jan G
JG
D000208:Acute Disease; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D010149:Postoperative Pain / Q000188:drug therapy; D010328:Patch Tests; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
D000701:Analgesics, Opioid; D009020:Morphine