beta-Glucosidase inhibitory activities of phenylpropanoid glycosides, vanicoside A and B from Polygonum sachalinense rhizome.
The phenylpropanoid glycosides, vanicoside A and B, isolated from rhizomes of giant knotweed (Polygonum sachalinense) showed beta-glucosidase inhibitory activity, with IC(50) values of 59.8 and 48.3 mug/ml (59.9 and 50.5 muM), respectively. In contrast, p-coumaric acid and ferulic acid, corresponding to phenylpropanoyl moieties of vanicosides, exhibited very little inhibition.
Kawai
Y
Y
Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan. kawai@fish.hokudai.ac.jp
Kumagai
H
H
Kurihara
H
H
Yamazaki
K
K
Sawano
R
R
Inoue
N
N
D002934:Cinnamates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D028502:Polygonum; D027343:Rhizome; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*
D002934:Cinnamates; D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; C087106:vanicoside B; C087105:vanicoside A; D001617:beta-Glucosidase