Successful treatment of breakthrough Trichosporon asahii fungemia with voriconazole in a patient with acute myeloid leukemia.
We describe a 55-year-old man with acute myelogenous leukemia who developed breakthrough Trichosporon asahii fungemia during 5 days of micafungin treatment. Although the patient's clinical condition improved considerably after the start of voriconazole treatment, blood culture results remained positive for T. asahii for 3 days, and fever persisted for 7 days thereafter. The patient achieved complete hematological remission, and he received successful consolidation chemotherapy without developing Trichosporon infection with the prophylactic use of voriconazole therapy. This case report illustrates that voriconazole may be useful in the treatment of disseminated T. asahii infection in neutropenic patients.
Asada
Noboru
N
Division of Hematology/Oncology, Department of Medicine, Kameda General Hospital, Chiba, 296-8602, Japan.
Uryu
Hidetaka
H
Koseki
Mihoko
M
Takeuchi
Masami
M
Komatsu
Masaru
M
Matsue
Kosei
K
D000208:Acute Disease; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy; D054714:Echinocandins; D016469:Fungemia / Q000188:drug therapy; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D055666:Lipopeptides; D008074:Lipoproteins / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D010456:Peptides, Cyclic / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D014250:Trichosporon / Q000302:isolation & purification*; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D000077551:Micafungin