title: [Natural immunity and herpes infection].
abstract: The review details natural immunological factors that are the first-line protection from herpes simplex virus. These reactions may be conventionally divided into 3 active phases. In Phase 1, the virus is attacked by proteins, such as complement of precursors of natural class M (IgM) antibodies and antimicrobial peptides. In Phase 2, the interferons produced by infected epithelial and resident dendritic cells go into action. And, finally, in Phase 3, effector cells, such as neutrophils, macrophages, and natural killer cells, show antiviral activity.
authors.forename: V F
authors.initials: VF
authors.lastname: Lavrov
authors.forename: L V
authors.initials: LV
authors.lastname: Koval'chuk
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaia
authors.forename: O A
authors.initials: OA
authors.lastname: Barkevich
authors.forename: S N
authors.initials: SN
authors.lastname: Kuzin
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000276:immunology; D023082:Defensins / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D006558:Herpes Genitalis / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D018258:Herpesvirus 2, Human / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis
chemical_list: D023082:Defensins; D003165:Complement System Proteins; D007372:Interferons