Myostatin: biology and clinical relevance.
Myostatin is a negative regulator of muscle mass. Important advances in our understanding of the complex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Here we present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.
Carnac
Gilles
G
Adult stem cells and Facio Scapulo Humeral dystrophy, CRBM, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France.
Ricaud
Stéphanie
S
Vernus
Barbara
B
Bonnieu
Anne
A
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D006801:Humans; D009132:Muscles / Q000378:metabolism; D009136:Muscular Dystrophies / Q000378:metabolism; D055435:Myostatin; D012208:Rhabdomyosarcoma / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
C525911:MSTN protein, human; D055435:Myostatin; D016212:Transforming Growth Factor beta