TreeDet: a web server to explore sequence space.
The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the relation between sequence conservation and evolutionary importance. TreeDet fully analyses the space of protein sequences in either user-uploaded or automatically generated multiple sequence alignments. The methods implemented in the server represent three main classes of methods for the detection of family-dependent conserved positions, a tree-based method, a correlation based method and a method that employs a principal component analyses coupled to a cluster algorithm. An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http://www.pdg.cnb.uam.es/servers/treedet.
Carro
Angel
A
Protein Design Group, CNB-CSIC C/Darwin n.3, 28049, Madrid, Spain.
Tress
Michael
M
de Juan
David
D
Pazos
Florencio
F
Lopez-Romero
Pedro
P
del Sol
Antonio
A
Valencia
Alfonso
A
Rojas
Ana M
AM
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D020407:Internet; D011506:Proteins / Q000145:classification; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
D011506:Proteins