title: Synthesis of 2,4-disubstituted 5-aminoimidazoles using microwave irradiation.
abstract: A microwave-assisted parallel synthesis of 2,4-disubstituted 5-aminoimidazoles has been developed. Significant rate enhancement was observed for all steps in the three-step protocol. The overall reaction time was shortened to 25 min, as compared to 53 h for the conventional procedures. A representative set of 2,4-disubstituted 5-aminoimidazoles was prepared using commercially available parallel reactors.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Chai Hoon
authors.initials: CH
authors.lastname: Soh
authors.forename: Wai Keung
authors.initials: WK
authors.lastname: Chui
authors.forename: Yulin
authors.initials: Y
authors.lastname: Lam
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007191:Indazoles / Q000138:chemical synthesis*; D008872:Microwaves; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D007191:Indazoles; C014974:5-aminoindazole