title: Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.
abstract: Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed. Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.
authors.affiliation: Department of Dermatology, University Medical Center Groningen, University of Groningen, The Netherlands. s.h.kardaun@derm.umcg.nl
authors.forename: Sylvia H
authors.initials: SH
authors.lastname: Kardaun
authors.forename: Jan G
authors.initials: JG
authors.lastname: de Monchy
mesh_terms: D000208:Acute Disease; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D010149:Postoperative Pain / Q000188:drug therapy; D010328:Patch Tests; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine