title: Usefulness of pulsed-wave tissue Doppler echocardiography for the assessment of the left and right ventricular function in patients with clinical hypothyroidism.
abstract: Clinical hypothyroidism (HT) is often associated with cardiovascular disorders, such as endothelial and myocardial dysfunction. Previous studies have explored left ventricular (LV) function using pulsed-wave tissue Doppler echocardiography (TDE) in HT. However, no study has utilized this technique in the assessment of right ventricular (RV) function in HT. Accordingly, we investigated the effects of clinical HT on LV and RV function by TDE. The study subjects included 35 newly diagnosed HT patients and 32 healthy normal controls. For each subject, serum FT3, FT4, TT3, TT4, and thyroid stimulating hormone (TSH) levels were measured, and standard echocardiography and TDE were performed. No statistically significant difference was found between patients and controls with regard to age, gender, body mass index, heart rate, and blood pressure. Compared to controls, TSH levels were significantly higher, and TT4 and FT4 levels were significantly lower. TDE showed that patients had significantly lower early diastolic tricuspid annular velocity (Ea) and early/late (Ea/Aa) diastolic tricuspid annular velocity ratio (P < 0.001 and P < 0.001, respectively), and significantly longer isovolumetric relaxation time (P < 0.001) than those of the controls. Aa, Sa, isovolumetric contraction time, and ejection time did not significantly differ. In addition, a significant relationship between some TDE indexes, and thyroid hormones (TT4 and FT4) and TSH was observed. We showed that patients with clinical HT are associated with impaired RV diastolic function, in addition to impaired LV diastolic function using TDE.
authors.affiliation: Department of Cardiology, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey. mferidunkosar@yahoo.com
authors.forename: Feridun
authors.initials: F
authors.lastname: Kosar
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sahin
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Aksoy
authors.forename: Elmas
authors.initials: E
authors.lastname: Uzer
authors.forename: Nedim
authors.initials: N
authors.lastname: Turan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000503:physiopathology; D008297:Male; D013963:Thyroid Hormones / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology
chemical_list: D013963:Thyroid Hormones