title: Interrelationship between glucose and fat utilisation during simultaneous IV administration of glucose and lipid emulsion in healthy man.
abstract: In order to evaluate the interaction between glucose and fat utilisation during parenteral nutrition, we studied 12 healthy volunteers under three different conditions: While Intralipid infusion does not alter the glucose utilisation, measured by metabolic clearance rate of glucose at an insulin level of about 80 uU/ml (MCR(glu)submax) 11.3 +/- 1 v.s. 11.48 +/- 0.9 ml/kg/min) and the sensitivity index, it decreases glucose utilisation at an insulin level of about 550 uU/ml (MCR(glu)max) (17.8 +/- 1.3 v.s. 15.9 +/- 0.9 ml/kg/min, p < 0.05) suggesting postreceptor alterations in insulin action. Simultaneous administration of Intralipid with glucose and insulin is associated with a smaller increase in serum triglycerides than the infusion of Intralipid alone (2.56 +/- 0.4 v.s. 5.44 +/- 0.5 mmol/lm p < 0.001). We conclude that, when infused at standard rates, Intralipid does not decrease glucose utilisation significantly and, at the same time, its own clearance is enhanced by glucose and insulin.
authors.affiliation: Institute for Clinical and Experimental Medicine, Vídenská 800, 140 00 Prague, Czechoslovakia.
authors.forename: T
authors.initials: T
authors.lastname: Pelikánová
authors.forename: M
authors.initials: M
authors.lastname: Andel
authors.forename: M
authors.initials: M
authors.lastname: Kohout
authors.forename: J
authors.initials: J
authors.lastname: Válek
authors.forename: L
authors.initials: L
authors.lastname: Kazdová