Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).
Preliminary investigations, studying gene expression and biochemical activities of enzymes d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1), revealed elevated cerebellar KAT-1 and DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals. In addition, we have identified a transcript of DAAO, which was expressed in significantly higher quantities in the diseased cerebellum but not detected in the parietal cortex where DAAO activity is absent.
Kapoor
Ranjna
R
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia. Electronic address: rkapoor@meddent.uwa.edu.au.
Lim
Kelly Sy
KS
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia.
Cheng
Alice
A
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia.
Garrick
Therese
T
The Australian Brain Donor Programs NSW Tissue Resource Centre, Department of Pathology, DO6, University of Sydney, Sydney 2006, Australia.
Kapoor
Vimal
V
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia.
D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D002531:Cerebellum / Q000201:enzymology* / Q000503:physiopathology; D003605:D-Amino-Acid Oxidase / Q000235:genetics / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006801:Humans; D008024:Ligands; D008959:Models, Neurological; D010296:Parietal Lobe / Q000201:enzymology / Q000503:physiopathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D018009:Receptors, Glycine / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012559:Schizophrenia / Q000201:enzymology* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology; D000637:Transaminases / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
D008024:Ligands; D020033:Protein Isoforms; D012333:RNA, Messenger; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D003605:D-Amino-Acid Oxidase; D000637:Transaminases; C021481:kynurenine-oxoglutarate transaminase