[The principles and the routes of progestagenes' administration in PCOS].
One of the chief findings in polycystic ovaries syndrome may be the defective luteal phase of the menstrual cycle. There is a growing list of publications indicating a defective progesterone production by granulosa cells of ovarian follicles. In consequence, women with polycystic ovaries often require both the luteal phase and early pregnancy supplementation. From different routes of progesterone administration during the menstrual cycle, as the most clinically reliable in the early pregnancy either intramuscular or intravaginal route has been recommended.
Krzysiek
Józef
J
Dept of Gynecological Endocrinology, Jagiellonian University, Cracow, Poland. sekret.endo@interia.pl
Krzyczkowska-Sendrakowska
Magdalena
M
Milewicz
Tomasz
T
D000282:Administration, Intravaginal; D004333:Drug Administration Routes; D005260:Female; D006107:Granulosa Cells / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007273:Injections, Intramuscular; D008183:Luteal Phase / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage; D011372:Progestins / Q000008:administration & dosage*
D011372:Progestins; D011374:Progesterone