Snail in the frame of malignant tumor recurrence.
Snail plays an important role in the epithelial-to-mesenchymal transition during development and in tumor progression. Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells. Recently, a new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model. Comparative transcriptome analysis of human primary breast cancers suggests that elevated Snail expression is correlated with decreased relapse-free survival. Further characterization of Snail as master regulator in this process might enhance our understanding of the molecular and cellular changes during and after breast tumor recurrence.
De Craene
Bram
B
Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, VIB-Ghent University, Belgium.
Berx
Geert
G
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D018450:Disease Progression; D004847:Epithelial Cells; D005260:Female; D015870:Gene Expression; D006801:Humans; D059630:Mesenchymal Stem Cells; D051379:Mice; D008822:Mice, Transgenic; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011237:Predictive Value of Tests; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics*
D000071250:Snail Family Transcription Factors; D014157:Transcription Factors