The FLP-side of nematodes.
The central role of FMRFamide-like peptides (FLPs) in nematode motor and sensory capabilities makes FLP signalling an appealing target for new parasiticides. Accumulating evidence has revealed an astounding level of FLP sequence conservation and diversity in the phylum Nematoda, and preliminary work has begun to identify the nematode FLP receptor complement in Caenorhabditis elegans, with a view to investigating their basic biology and therapeutic potential. However, much work is needed to clarify the functional aspects of FLP signalling and how these peptides exert their effects at the organismal level. Here, we summarize our current knowledge of nematode FLP signalling.
McVeigh
Paul
P
Parasitology, School of Biological Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. paul.mcveigh@qub.ac.uk
Geary
Timothy G
TG
Marks
Nikki J
NJ
Maule
Aaron G
AG
D000818:Animals; D044822:Biodiversity; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D019835:FMRFamide / Q000235:genetics* / Q000502:physiology*; D015870:Gene Expression; D009348:Nematoda / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D013045:Species Specificity
D019835:FMRFamide