title: Impact of organ malperfusion on mortality and morbidity in acute type A aortic dissections.
abstract: BACKGROUND
  Organ malperfusion is a serious complication of acute type A aortic dissection. Management and outcome of malperfusion has been discussed in this study.
  
  
  METHODS
  Between November 1994 and May 2003, 118 patients with acute type A aortic dissections were operated. Fifty-seven patients (48.3%) were complicated with organ malperfusion, which is considered as group I. Seventy-three ischemic events were seen in 57 patients with organ malperfusion. Patients in group I were divided into four subgroups according to affected organ system including limb (38 events), coronary (9 events), renal (2 events), visceral (9 events), and cerebral (15 events) ischemia. Sixty-one patients without organ malperfusion constitute group II.
  
  
  RESULTS
  The hospital mortality rate was 42.1% (24 of 57) in patients with malperfusion, 14.75% (9 of 61) in group II (p = 0.001), and 27.9% (33 of 118) in all patients. Postoperative complications such as mediastinal hemorrhage, low cardiac output, gastrointestinal system complications, acute renal failure, and multiple organ failure were higher in group I. Mesenteric and limb ischemia associated with high mortality. Multivariate analysis reveals that visceral malperfusion is the strongest predictor of postoperative mortality (odds ratio: 25.09, p = 0.000). Isolated coronary malperfusion had the lowest mortality (one patient, 16.6%) among the patients with organ malperfusion.
  
  
  CONCLUSIONS
  Acute type A aortic dissections with organ malperfusion has higher postoperative mortality and morbidity. Immediate aortic repair is our management strategy in patients with limb, coronary, and neurological malperfusion. To reduce the extremely high mortality with mesenteric malperfusion, new strategies should be investigated such as surgical delay with interventional procedures.
authors.affiliation: Ege University Hospital, Department of Cardiovascular Surgery, Izmir, Turkey. tyagdi@med.ege.edu.tr
authors.forename: Tahir
authors.initials: T
authors.lastname: Yagdi
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Atay
authors.forename: Cagatay
authors.initials: C
authors.lastname: Engin
authors.forename: Resad
authors.initials: R
authors.lastname: Mahmudov
authors.forename: Omer
authors.initials: O
authors.lastname: Tetik
authors.forename: Hikmet
authors.initials: H
authors.lastname: Iyem
authors.forename: Hakan
authors.initials: H
authors.lastname: Posacioglu
authors.forename: Anil Z
authors.initials: AZ
authors.lastname: Apaydin
authors.forename: Suat
authors.initials: S
authors.lastname: Buket
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000784:Aortic Dissection / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D001014:Aortic Aneurysm / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D001921:Brain / Q000098:blood supply; D003327:Coronary Disease / Q000209:etiology / Q000401:mortality; D005121:Extremities / Q000098:blood supply; D005260:Female; D006083:Graft Occlusion, Vascular / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007511:Ischemia / Q000209:etiology; D007668:Kidney / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome; D014781:Viscera / Q000098:blood supply