title: Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX.
abstract: New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
authors.affiliation: Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-606, Republic of Korea.
authors.forename: Kyung-Ae
authors.initials: KA
authors.lastname: Oh
authors.forename: Garp Yeol
authors.initials: GY
authors.lastname: Yang
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Jung
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000110:Acetylcholinesterase; D003432:Cross-Linking Reagents; D004987:Ethers; D009946:Organothiophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; C402362:bispyridinium oxime BP12; C009680:VX-agent