[Morphological and immunohistogenetical features of colon cancer in children].
We carried out postmortem and immunohistological studies of 3 cases of colon cancer in a 14-year-old (case 1) and an 8-year-old girl (case 2), and Turcot's syndrome in a 14-year-old girl (case 3). Tumors were located in the proximal portions of the colon and they were of rare histological types. The expression of proteins--the products of MLH 1, MHS2, and MHS6 genes responsible for DNA reparation was estimated. There was no expression of MLH1 and MHS6 in cases 2 and 3, respectively. The findings enabled the authors to assign these cases to hereditary polyposis-unassociated colonic cancer that is also a variety of Turcot's syndrome.
Talalaev
A G
AG
Tertychnyĭ
A S
AS
Konovalov
D M
DM
Val'kov
A Iu
AIu
Marenich
N S
NS
D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D002352:Carrier Proteins / Q000032:analysis*; D002648:Child; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000070957:MutL Protein Homolog 1; D009687:Nuclear Proteins / Q000032:analysis*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D000070957:MutL Protein Homolog 1