Clinical and biological features of multiple myeloma involving the gastrointestinal system.
We report 24 cases of multiple myeloma (MM) with involvement of the gastrointestinal (GI) system. We found a strong association with high A lactate dehydrogenase levels, plasmablastic morphology, and A unfavorable karyotype. GI involvement at the time of initial diagnosis was much rarer than later in the course of the disease. The A median survival after diagnosis of GI involvement was 7 months. Among 13 patients treated with stem cell transplantation, the response rate was 92%, and median progression-free survival was 4 months. We conclude that MM involving the GI system is associated with adverse biological features and with short-lasting remissions, even after A high-dose chemotherapy.
Talamo
Giampaolo
G
Myeloma Institute for Research and Therapy, Division of Gastroenterology, The University of Arkansas for Medical Sciences, 4301 West Markham Street/Slot 776, Little Rock, Arkansas 72205, USA.
Cavallo
Federica
F
Zangari
Maurizio
M
Barlogie
Bart
B
Lee
Choon-Kee
CK
Pineda-Roman
Mauricio
M
Kiwan
Elias
E
Krishna
Somashekar
S
Tricot
Guido
G
D001706:Biopsy; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D009101:Multiple Myeloma / Q000000981:diagnostic imaging*; D015999:Multivariate Analysis; D014057:Tomography, X-Ray Computed / Q000592:standards; D018608:Ultrasonography, Doppler / Q000379:methods / Q000592:standards*