title: [Family incidence of latent autoimmune diabetes in adults--case report].
abstract: We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electrolyte depletion, acidosis. However plasma level of C peptide basal and after stimulation with glucagon was reduced. Initially, the patient responded well to sulphonylurea treatment. To test immunological pathogenesis we examine autoimmune markers of diabetes type 1. Autoimmune antibodies (GAD, IAA) were found in patients and her parents, which were until now diabetic type 2. We report this case because incidence of latent autoimmune diabetes in adults is underestimate and rarely diagnosed in clinical practice.
authors.affiliation: Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Białystok. barabara@amb.edu.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Szepietowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szelachowska
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D010375:Pedigree
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D002096:C-Peptide; C024211:islet cell antibody