[3+2] cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles.
[Structure: see text] An efficient and regioselective procedure for the synthesis of 1,2,3-triazoles via a [3+2] cycloaddition of polymer-bound vinyl sulfone and sodium azide is described. Microwave irradiation provided significant rate enhancement in all steps of the three-step protocol. A representative set of 23 compounds was prepared.
Gao
Yongnian
Y
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Lam
Yulin
Y