title: Fulminant Lewy body disease.
abstract: The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.
authors.affiliation: Department of Neurology, Geneva University Hospitals and Medical School, Geneva, Switzerland.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Momjian-Mayor
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Pizzolato
authors.forename: Karim
authors.initials: K
authors.lastname: Burkhardt
authors.forename: Theodor
authors.initials: T
authors.lastname: Landis
authors.forename: Alessandra
authors.initials: A
authors.lastname: Coeytaux
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Burkhard
mesh_terms: D048948:14-3-3 Proteins / Q000032:analysis; D000368:Aged; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology
chemical_list: D048948:14-3-3 Proteins