title: Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences.
abstract: G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.
authors.affiliation: GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology CSIR, Mall Road, Delhi 110 007, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Scaria
authors.forename: Manoj
authors.initials: M
authors.lastname: Hariharan
authors.forename: Amit
authors.initials: A
authors.lastname: Arora
authors.forename: Souvik
authors.initials: S
authors.lastname: Maiti
mesh_terms: D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D020407:Internet; D012313:RNA / Q000737:chemistry; D017422:Sequence Analysis, DNA / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D006147:Guanine; D012313:RNA; D004247:DNA