title: [Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model].
abstract: OBJECTIVE
  To investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model at different stages of inflammation of varied severity.
  
  
  METHODS
  The periodontal tissues were immunohistochemically stained by antibody of MMP-2 and MMP-3.
  
  
  RESULTS
  MMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodontitis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis.
  
  
  CONCLUSIONS
  The expression of MMP-2 and MMP-3 varies in different stage of periodontitis. MMP-2 and MMP-3 may play an important role in development of periodontitis.
authors.affiliation: Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Zhao
authors.forename: Shu
authors.initials: S
authors.lastname: Meng
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Ge
mesh_terms: D000818:Animals; D055113:Chronic Periodontitis; D005347:Fibroblasts; D005891:Gingivitis; D008297:Male; D020778:Matrix Metalloproteinase 2; D010513:Periodontal Ligament; D010518:Periodontitis; D051381:Rats
chemical_list: D020778:Matrix Metalloproteinase 2