title: [Giant cell tumor of soft tissues. Report of two cases].
abstract: We report two cases of giant-cell tumour of soft tissue (TCG-TM). The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg. Pathological study revealed a tumour comparable to benign giant cell tumour of bone. The patient is well without recurrence 10 months after the diagnosis. The second case concerned a 49-year-old man with a huge mass of the thigh. Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells. Mononuclear cells presented severe atypia and a high mitotic activity. Eighteen months later, the patient died with diffuse pulmonary metastases. TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone. The malignant variant is debatable. The differential diagnosis includes other tumours rich in osteoclast-like cells.
authors.affiliation: Service d'Anatomie Pathologique, CHRU, Pôle Biologie Pathologie, Eurasanté, Avenue Oscar Lambret, 59037 Lille Cedex.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Ech-Charif
authors.forename: Sébastien
authors.initials: S
authors.lastname: Aubert
authors.forename: David
authors.initials: D
authors.lastname: Buob
authors.forename: Priscilla
authors.initials: P
authors.lastname: Verhulst
authors.forename: Valérie
authors.initials: V
authors.lastname: Blomme
authors.forename: Henri
authors.initials: H
authors.lastname: Migaud
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology; D005260:Female; D005870:Giant Cell Tumors / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*