IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.
How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.
Sosa
Lucas
L
Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba y Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Consejo de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
Dupraz
Sebastian
S
Laurino
Lisandro
L
Bollati
Flavia
F
Bisbal
Mariano
M
Cáceres
Alfredo
A
Pfenninger
Karl H
KH
Quiroga
Santiago
S
D000818:Animals; D016764:Cell Polarity; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism*; D020917:Receptor, trkA / Q000378:metabolism; D020813:Receptor, trkB / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
D034741:RNA, Small Interfering; D019869:Phosphatidylinositol 3-Kinases; D017526:Receptor, IGF Type 1; D020917:Receptor, trkA; D020813:Receptor, trkB; D020764:cdc42 GTP-Binding Protein