Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.
Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.
Goel
Anubhuthi
A
Department of Biology, University of Maryland, College Park, Maryland 20742, USA.
Jiang
Bin
B
Xu
Linda W
LW
Song
Lihua
L
Kirkwood
Alfredo
A
Lee
Hey-Kyoung
HK
D000818:Animals; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D021122:Protein Subunits / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D018091:Receptors, AMPA / Q000378:metabolism*; D012683:Sensory Deprivation; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
D021122:Protein Subunits; D018091:Receptors, AMPA