title: Pro/con debate: octreotide has an important role in the treatment of gastrointestinal bleeding of unknown origin?
abstract: Whether it is the primary reason for admission or a complication of critical illness, upper gastrointestinal bleeding is commonly encountered in the intensive care unit. In this setting, in the absence of endoscopy, intensivists generally provide supportive care (transfusion of blood products) and acid suppression (such as proton pump inhibitors). More recently, octreotide (a somatostatin analogue) has been used in such patients. However, its precise role in patients with upper gastrointestinal bleeding is not necessarily clear and the drug is associated with significant costs. In this issue of Critical Care, two expert teams debate the merits of using octreotide in non-variceal upper gastrointestinal bleeding.
authors.affiliation: Intensive Care Unit, King Abdulaziz Medical City, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11426, Saudi Arabia.
authors.forename: Yaseen
authors.initials: Y
authors.lastname: Arabi
authors.forename: Bandar
authors.initials: B
authors.lastname: Al Knawy
authors.forename: Alan N
authors.initials: AN
authors.lastname: Barkun
authors.forename: Marc
authors.initials: M
authors.lastname: Bardou
mesh_terms: D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D015282:Octreotide / Q000191:economics / Q000627:therapeutic use*
chemical_list: D015282:Octreotide