Suppression of alcohol consumption in C57Bl/6 mice after intranasal administration of antiserotonin antibodies.
Experiments on C57Bl/6 mice under conditions of free choice between alcohol and water for 10 months showed that intranasal administration with antiserotonin antibodies in doses of 30 and 15 microg/kg for 2 week decreased alcohol consumption over 1 month after treatment.
Davydova
T V
TV
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences.
Fomina
V G
VG
Basharova
L A
LA
Fedenko
A M
AM
D000281:Administration, Intranasal; D000427:Alcohol Deterrents / Q000494:pharmacology*; D000428:Alcohol Drinking; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001522:Behavior, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012701:Serotonin / Q000276:immunology*; D013997:Time Factors; D005719:gamma-Globulins / Q000378:metabolism
D000427:Alcohol Deterrents; D000906:Antibodies; D005719:gamma-Globulins; D012701:Serotonin