MRI characteristics of parosteal lipomas associated with the HMGA2-LPP fusion gene.
BACKGROUND
The magnetic resonance (MR) characteristics of parosteal lipomas with the HMGA2-LPP fusion transcripts are described.


METHODS
The expression of HMGA2-LPP fusion transcripts was determined using the reverse transcription-polymerase chain reaction method.


RESULTS
MR images of two cases with the fusion transcripts, a 56-year-old man and a 50-year-old woman, revealed heterogeneous high signal intensities on T1- and T2-weighted images, showing heterogeneous curvilinear enhancement on fat-suppressed T1-weighted images after Gd-DTPA injection, which resembled those of well-differentiated liposarcomas.


CONCLUSIONS
Since the HMGA2-LPP fusion transcripts are exclusively detectable in benign mesenchymal tumors, testing HMGA2-LPP expression may be useful for differential diagnosis in cases of radiologically-suspected well-differentiated liposarcomas.
Kubo
Takahiro
T
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Matsui
Yoshito
Y
Goto
Tomohiro
T
Yukata
Kiminori
K
Endo
Kenji
K
Sato
Ryosuke
R
Tsutsui
Takahiko
T
Yasui
Natsuo
N
D005260:Female; D024003:HMGA Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008067:Lipoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000096:biosynthesis / Q000235:genetics*; D010521:Periosteum; D020133:Reverse Transcriptase Polymerase Chain Reaction
D024003:HMGA Proteins; C502535:HMGA2-LPP fusion protein, human; D015514:Oncogene Proteins, Fusion