title: [Combined therapy in glaucoma treatment: travoprost 0.004% and brinzolamid].
abstract: OBJECTIVE
  To evaluate the efficacy of travoprost 0.004% and brinzolamide 1% combined therapy in patients unsuccessfully treated with a combination of timolol 0.5% and brinzolamide 1%.
  
  
  METHODS
  The study was conducted in 30 adult patient with primary open angle glaucoma (14 men and 16 women, mean age 68.5 years) who required change in therapy. Intraocular pressure was measured at entry, and on day 15, 45 and 90 thereafter.
  
  
  RESULTS
  The initial mean intraocular pressure was 21.62 mm Hg. Therapy modification (travoprost 0.004% instead of timolol 0.5%), resulted in intraocular pressure reduction by 5.67 mm Hg on day 15, and by 6.37 mm Hg on days 45 and 90.
  
  
  CONCLUSIONS
  The study showed travoprost 0.004% combined with brinzolamide 1% to provide a statistically significant reduction (p < 0.001) in intraocular pressure in patients who could not been successfully treated with timolol 0.5% and brinzolamide 1%.
authors.affiliation: Klinika za ocne bolesti Medicinskog fakulteta, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska.
authors.forename: Smiljka
authors.initials: S
authors.lastname: Popović Suić
authors.forename: Nenad
authors.initials: N
authors.lastname: Vukojević
authors.forename: Branimir
authors.initials: B
authors.lastname: Cerovski
authors.forename: Tomislav
authors.initials: T
authors.lastname: Jukić
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D013449:Sulfonamides / Q000008:administration & dosage*; D013843:Thiazines / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage; D000069557:Travoprost
chemical_list: D000319:Adrenergic beta-Antagonists; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013843:Thiazines; D003008:Cloprostenol; D013999:Timolol; C111827:brinzolamide; D000069557:Travoprost