title: Short wavelength-automated perimetry compared with standard achromatic perimetry in autosomal dominant optic atrophy.
abstract: BACKGROUND
  Autosomal dominant optic atrophy (ADOA, Kjer-type) is a heterogeneous, non-inflammatory degeneration of retinal ganglion cells. The diagnosis of ADOA can be challenging owing to its insidious onset and large variability in phenotypic expression, both within and between individual pedigrees. The earliest literature reports relatively mild centrocaecal scatomas to white targets in ADOA, but extensive and dense peripheral field loss to coloured targets, especially blue, with Bjerrum perimetry. The phrase "inverted peripheral visual fields to coloured targets" has been used to describe this phenomenon.
  
  
  METHODS
  Humphrey standard achromatic perimetry (SAP) and short wavelength-automated perimetry (SWAP) were carried out on five patients with ADOA.
  
  
  RESULTS
  Regardless of wide variations in patient age, visual acuity, disc appearance and colour vision, the SWAP mean deviation (MD) was between 10 and 20 times more depressed than the SAP MD. The actual differences ranged from 9.38 to 13.78 dB.
  
  
  CONCLUSIONS
  These data are consistent with the original reports suggesting that, early in this disease process, the blue-target deficits are typically peripheral and that this difference between SAP and SWAP perimetry may be a robust indicator of ADOA in both early and late stages of this disease.
authors.affiliation: College of Optometry, University of Houston, J Davis Armistead Building, Houston, TX 77204-6052, USA. dr_jimwalters@yahoo.com
authors.forename: J W
authors.initials: JW
authors.lastname: Walters
authors.forename: A
authors.initials: A
authors.lastname: Gaume
authors.forename: L
authors.initials: L
authors.lastname: Pate
mesh_terms: D000293:Adolescent; D000328:Adult; D003117:Color Vision Defects / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029241:Optic Atrophy, Autosomal Dominant / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields