A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia.
E-selectin, which is a member of the selectin superfamily of adhesion molecules, contributes to the leukocyte-endothelial cell attachments and is involved in the pathogenesis of thrombovascular diseases as a consequence. We investigated the A561C mutation in the E-selectin gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 301 age- and sex-matched healthy controls. Excluding the subjects with diabetes mellitus and hypercholesterolemia, the AC genotype frequencies of patients with ischemic CVD were higher than those of controls: 12.7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.
Hattori
Hidenori
H
Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160-8582, Japan. hidehatt@1999.jukuin.keio.ac.jp
Sato
Hideki
H
Ito
Daisuke
D
Tanahashi
Norio
N
Murata
Mitsuru
M
Saito
Ikuo
I
Watanabe
Kiyoaki
K
Suzuki
Norihiro
N
D000368:Aged; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002448:Cell Adhesion / Q000235:genetics; D002536:Cerebral Arteries / Q000378:metabolism* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000235:genetics; D048909:Diabetes Complications / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D020767:Intracranial Thrombosis / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D019040:E-Selectin