title: An expeditious enantioselective total synthesis of valilactone.
abstract: The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic centers and a hydroxyl group activation (HGA) protocol to construct the anti alpha,beta-disubstituted beta-lactone from the corresponding syn aldol.
authors.affiliation: State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. yikangwu@mail.sioc.ac.cn
authors.forename: Yikang
authors.initials: Y
authors.lastname: Wu
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Sun
mesh_terms: D003500:Cyclization; D017665:Hydroxyl Radical / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007783:Lactones; C054478:valilactone; D017665:Hydroxyl Radical