Current and new strategies for the delivery of antiseptic agents.
The present mini-review explores the current methods used for the delivery of antiseptics and topical antimicrobials. Relevance of hand scrub with antiseptic liquid soap (e.g. chlorhexidine, PVP-iodine, triclosan) and alcohol-based hand rub is discussed and compared in terms of bactericidal activity, skin tolerance, and medical staff observance. New strategies for antibacterial delivery focus on the challenge of colloidal drug carrier such as liposomes, micro- and nanoparticles enabling sustained bactericidal effect and effective bacterial targeting.
Constant
Hélène
H
Pharmacie, Hôpital Debrousse, Hospices Civils de Lyon, 29, rue Saeur Bouvier F-69322 Lyon Cedex 05 - France.
Falson
Françoise
F
Pirot
Fabrice
F
D019840:2-Propanol / Q000008:administration & dosage / Q000627:therapeutic use; D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012867:Skin / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure
D000891:Anti-Infective Agents, Local; D019840:2-Propanol