title: Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.
abstract: OBJECTIVE
  To investigate the correlation between expression of CD58 and severity of hepatitis B.
  
  
  METHODS
  The level of soluble CD58 (sCD58) in serum of patients with hepatitis B was detected by enzyme-linked immunosorbent assay. The level of expression of membrane CD58 molecule in PBMC was detected by direct immunofluorescence. The levels of serumal TBIL, DBIL, IBIL, ALT and AST were detected by the automated biochemistry analyzer as well.
  
  
  RESULTS
  The levels of sCD58 in serum and membrane CD58 molecule in PBMC of patients with hepatitis B were significantly higher than that in normal controls (P < 0.05). Level of CD58 was related to the levels of serumal TBIL, DBIL, IBIL, ALT and AST.
  
  
  CONCLUSIONS
  The level of CD58 molecule (in both serum and PBMC form) of patients with hepatitis B is related to the degree of liver damage.
authors.affiliation: Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Bao-Tai
authors.initials: BT
authors.lastname: Qi
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Ji
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Meng
authors.forename: Ming
authors.initials: M
authors.lastname: Xie
mesh_terms: D018968:CD58 Antigens / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation; D006509:Hepatitis B / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D018968:CD58 Antigens