title: Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact.
abstract: Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.
authors.affiliation: Department of General Surgery, University Medical Center Göttingen, Germany.
authors.forename: Marian
authors.initials: M
authors.lastname: Grade
authors.forename: Heinz
authors.initials: H
authors.lastname: Becker
authors.forename: Torsten
authors.initials: T
authors.lastname: Liersch
authors.forename: Thomas
authors.initials: T
authors.lastname: Ried
authors.forename: B Michael
authors.initials: BM
authors.lastname: Ghadimi
mesh_terms: D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D020732:Cytogenetic Analysis / Q000379:methods*; D018450:Disease Progression; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D009693:Nucleic Acid Hybridization / Q000379:methods; D032681:Spectral Karyotyping / Q000379:methods