title: Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.
abstract: Natural killer (NK) cells are critical for the first-line defense in infection. Treated viremic HIV-1 infection is associated with the expansion of an anergic subset of CD3-CD56-CD16+ NK cells unable to respond to stimulation with MHC-devoid target cells or with mitogens. These CD3-CD56-CD16+ NK cells expressed SHIP-1 and had significantly reduced perforin levels. This observation suggests a mechanism for the reduced functional activity of CD3-CD56-CD16+ NK cells in chronic HIV-1 infection.
authors.affiliation: Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Suscovich
authors.forename: Marianna
authors.initials: M
authors.lastname: Kleyman
authors.forename: Nickolas
authors.initials: N
authors.lastname: Teigen
authors.forename: Hendrik
authors.initials: H
authors.lastname: Streeck
authors.forename: M Tauheed
authors.initials: MT
authors.lastname: Zaman
authors.forename: Angela
authors.initials: A
authors.lastname: Meier
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
mesh_terms: D002908:Chronic Disease; D017635:Clonal Anergy; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D000072181:Inositol Polyphosphate 5-Phosphatases; D007694:Killer Cells, Natural / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology; D008562:Membrane Glycoproteins / Q000097:blood*; D054353:Perforin; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000096:biosynthesis*; D052899:Pore Forming Cytotoxic Proteins
chemical_list: D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D010744:Phosphoric Monoester Hydrolases; D000072181:Inositol Polyphosphate 5-Phosphatases; C000606430:INPP5D protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases