title: Hypopituitarism findings in patients with primary brain tumors 1 year after neurosurgical treatment: preliminary report.
abstract: Hypopituitarism represents the consequence of many conditions, in both the adult and child population. It may occur after neurosurgical treatment of brain tumors arising near sella turcica. Much more attention has been focused on lesions far from the hypothalamic-pituitary region as possible causes of pituitary impairment, validating the concept of the particular fragility of these structures. The aim of this study was to evaluate pituitary function in particular GH deficiency (GHD) in patients submitted to neurosurgery for benign tumors of the central nervous system (CNS) not involving hypothalamic-pituitary region. We observed 37 patients with benign brain tumors [13 males, 24 females, age: 54.6+/-13.9 yr; body mass index (BMI): 25.1+/-4.0 kg/m2] performing a basic evaluation of the pituitary function and a dynamic test of the GH/IGF-I axis [GHRH (1 microg/kg iv)+arginine (0.5 g/kg iv) test] for 3 and 12 months after the neurosurgical treatment. Some degree of hypopituitarism was shown in 16 patients (43.2%) at the 3-months follow-up. Hypogonadism was present in 4 patients, hypoadrenalism in another 4 and hypothyroidism in 2. Two patients showed mild hyperprolactinemia and no patients had diabetes insipidus. Seven patients (18.9%) were GH deficient (peak GH <16.5 microg/dl). At 12 months retesting, some degree of hypopituitarism was confirmed in 8 patients, hypogonadism in 2 and hypothyroidism in one; no patients showed hypoadrenalism and GHD was present in 5. This data suggests that hypopituitarism of various degree may develop in patients who are submitted to neurosurgery for primary brain tumors, even far from hypothalamic-pituitary region.
authors.affiliation: Division of Endocrinology, Institute of Internal Medicine, Catholic University of Sacred Heart, 00189 Rome, Italy. laurademarinis@yahoo.it
authors.forename: L
authors.initials: L
authors.lastname: De Marinis
authors.forename: A
authors.initials: A
authors.lastname: Fusco
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Aimaretti
authors.forename: M R
authors.initials: MR
authors.lastname: Ambrosio
authors.forename: C
authors.initials: C
authors.lastname: Scaroni
authors.forename: S
authors.initials: S
authors.lastname: Cannavo
authors.forename: C
authors.initials: C
authors.lastname: Di Somma
authors.forename: F
authors.initials: F
authors.lastname: Mantero
authors.forename: E C
authors.initials: EC
authors.lastname: degli Uberti
authors.forename: G
authors.initials: G
authors.lastname: Giordano
authors.forename: E
authors.initials: E
authors.lastname: Ghigo
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine; D001932:Brain Neoplasms / Q000601:surgery*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007018:Hypopituitarism / Q000209:etiology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010901:Pituitary Function Tests; D011183:Postoperative Complications; D011446:Prospective Studies; D013002:Somatomedins / Q000032:analysis; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013002:Somatomedins; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D001120:Arginine; D013974:Thyroxine; D006854:Hydrocortisone