[Clinical analysis of intracytoplasmic sperm injection in patients with previous fertilization failure after conventional IVF].
OBJECTIVE
To analyze the clinical outcome of intracytoplasmic sperm injection (ICSI) in patients with previous fertilization failure after conventional IVF.


METHODS
Data from 20 ICSI cases (22 ICSI cycles) with previous complete failure of fertilization or with fertilization rate < or = 20% between January 2002 and December 2004 were retrospectively analyzed. The control group consisted of 100 consecutive ICSI cycles for male factor infertility in the same period.


RESULTS
The fertilization rate dramatically increased from 5.4% after conventional IVF to 76.9% after ICSI treatment (chi-squared = 264.66, P < 0.001). However, the fertilization rate in the subgroup with previous low fertilization was significantly lower than those in the control and in the subgroup without previous fertilization (67.9% vs 77.5%, 67.9% vs 84.2%). Compared with the control group, the subgroup without previous fertilization had a higher pregnancy rate and implantation rate, but only the difference in the implantation rate was statistically significant (40.5% vs 18.9%).


CONCLUSIONS
ICSI can overcome previous fertilization failure with conventional in vitro fertilization and thus improve the clinical outcome.
Xu
Yan-wen
YW
Reproductive Medical Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. xuyanwen@pub.guangzhou.gd.cn
Zhou
Can-quan
CQ
Fang
Cong
C
Zhang
Min-fang
MF
Deng
Ming-fen
MF
Zhang
Xiu-bing
XB
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure