ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins.
ScanProsite--http://www.expasy.org/tools/scanprosite/--is a new and improved version of the web-based tool for detecting PROSITE signature matches in protein sequences. For a number of PROSITE profiles, the tool now makes use of ProRules--context-dependent annotation templates--to detect functional and structural intra-domain residues. The detection of those features enhances the power of function prediction based on profiles. Both user-defined sequences and sequences from the UniProt Knowledgebase can be matched against custom patterns, or against PROSITE signatures. To improve response times, matches of sequences from UniProtKB against PROSITE signatures are now retrieved from a pre-computed match database. Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results.
de Castro
Edouard
E
Swiss Institute of Bioinformatics, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland. ecastro@isb-sib.ch
Sigrist
Christian J A
CJ
Gattiker
Alexandre
A
Bulliard
Virginie
V
Langendijk-Genevaux
Petra S
PS
Gasteiger
Elisabeth
E
Bairoch
Amos
A
Hulo
Nicolas
N
D000596:Amino Acids / Q000737:chemistry*; D030562:Databases, Protein; D020407:Internet; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D012984:Software; D014584:User-Computer Interface
D000596:Amino Acids; D011506:Proteins