Tumors face NO problems?
The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and difficult to define, with multiple reports of pro- and anti-cancer actions. Here we address the major factors that seem likely to account for these paradoxical behaviors, which include variability in NO production, heterogeneity in NO chemistry (and thus its cellular actions), and differential cellular responses. In addition, we suggest that a major determinant of the outcome of NO actions in the tumor environment is cellular adaptation/selection to the cytotoxic actions of NO.
Lancaster
Jack R
JR
Center for Free Radical Biology, Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Xie
Keping
K
D000818:Animals; D016923:Cell Death / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis / Q000378:metabolism
D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II