Plenty new under the sun.
Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populations. A range of variants predispose to skin cancer, including melanoma. What remains unclear are the mechanisms linking gene variation with sun sensitivity or tumor risk. In particular, it remains unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk.
Rees
Jonathan
J
Department of Dermatology, University of Edinburgh, Edinburgh United Kingdom. jonathan.rees@ed.ac.uk
D006801:Humans; D008545:Melanoma / Q000453:epidemiology* / Q000235:genetics*; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012880:Skin Pigmentation / Q000235:genetics
D044102:Receptor, Melanocortin, Type 1