Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond.
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Grossman
Aaron W
AW
Beckman Institute, University of Illinois at Urbana--Champaign, Urbana, Illinois 61801, USA.
Aldridge
Georgina M
GM
Weiler
Ivan Jeanne
IJ
Greenough
William T
WT
D000818:Animals; D049229:Dendritic Spines / Q000502:physiology*; D005600:Fragile X Syndrome / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology*