title: Postgenomic approaches to cholera vaccine development.
abstract: Cholera remains an important public health threat. A cholera vaccine that provides durable protection at the mucosal surface, especially among children in endemic settings, is urgently needed. The availability of the complete genome sequence of a clinical isolate of Vibrio cholerae O1 El Tor has allowed for comparative and functional genomic approaches in the study of cholera. This work holds promise for the identification of bacterial targets of protective human immune responses and may contribute to the development of a new generation of cholera vaccines.
authors.affiliation: Division of Infectious Diseases, Massachusetts General Hospital, GRJ 504, 55 Fruit Street, Boston, MA 02114, USA. rclarocque@partners.org
authors.forename: Regina C
authors.initials: RC
authors.lastname: LaRocque
authors.forename: Jason B
authors.initials: JB
authors.lastname: Harris
authors.forename: Edward T
authors.initials: ET
authors.lastname: Ryan
authors.forename: Firdausi
authors.initials: F
authors.lastname: Qadri
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Calderwood
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D002771:Cholera / Q000517:prevention & control*; D022121:Cholera Vaccines; D004195:Disease Models, Animal; D015195:Drug Design; D020869:Gene Expression Profiling; D016680:Genome, Bacterial; D006801:Humans; D041241:Vibrio cholerae O1 / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D022121:Cholera Vaccines