Influence of oral vitamin E therapy on micro-inflammation and cardiovascular disease markers in chronic hemodialysis patients.
BACKGROUND
The aim of this study was to evaluate the influence of oral vitamin E therapy on serum concentrations of several markers of micro-inflammation and cardiovascular disease in chronic hemodialysis (HD) patients.


METHODS
29 HD patients were randomized into two groups: 15 patients were treated orally with 400 mg of vitamin E daily for a period of five weeks, and 14 patients received no antioxidant supplementation. Before and after vitamin E therapy, serum concentrations of vitamin E (high-performance liquid chromatography), pregnancy-associated plasma protein-A (immunochemical--TRACE assay), C-reactive protein (nephelometry), intercellular adhesion molecule-1 (ELISA), and E-selectin (ELISA) were measured. HD patients were compared with 16 healthy controls.


RESULTS
Baseline serum concentrations of PAPP-A and CRP were significantly higher in HD patients than in healthy controls (PAPP-A: 26.23+/-11.94 vs. 11.41+/-1.94 mIU/L, p<0.001; CRP: 5.20+/-3.50 vs. 3.40+/-3.80 mg/L, p<0.05). After five weeks of oral vitamin E intake, serum PAPP-A, CRP, ICAM-1, and E-selectin concentrations remained unchanged in both groups of HD patients.


CONCLUSIONS
Chronic micro-inflammation in HD patients is documented by the elevation of CRP and PAPP-A. A daily oral dose of 400 mg of vitamin E does not seem to be able to reduce enhanced oxidative stress and micro-inflammation in chronic HD patients.
Hodkova
Magdalena
M
Department of Nephrology, Institute of Clinical Chemistry and Laboratory Diagnostics, General Teaching Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic. magdalena.hodkova@seznam.cz
Dusilova-Sulkova
Sylvie
S
Kalousova
Marta
M
Soukupova
Jirina
J
Zima
Tomas
T
Mikova
Dana
D
Malbohan
Ivan Matous
IM
Bartunkova
Jirina
J
D000284:Administration, Oral; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D006435:Renal Dialysis; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D014810:Vitamin E; D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A