title: Hemodynamic effects of a combination of bupropion and nicotine in anesthetized dogs.
abstract: Bupropion has been used to treat psychic depression and as a therapy for smoking cessation, the latter mainly in association with nicotine. However, there have been no detailed studies of the hemodynamic effects of the association of bupropion with nicotine during replacement therapy. In this study, we evaluated the effects of such an association on the cardiovascular parameters in anesthetized dogs. Bupropion, either alone or together with nicotine, had no significant effect on the cardiac index (CI; 4.7 +/- 0.2 vs 4.3 +/- 0.1 and 3.5 +/- 0.3 vs 3.4 +/- 0.3 L x min(-1) x m(2), respectively; mean +/- SEM) and mean arterial pressure (MAP; 134 +/- 5.0 vs 145 +/- 11.0 and 118 +/- 5.0 vs 133 +/- 10.5 mmHg, respectively). There was a slight but significant increase in the systemic vascular resistance index (SVRI; 2,165 +/- 93 vs 2,645 +/- 126 and 2,335 +/- 100 vs 2,737 +/- 200 dyn x cm(-5)m(-2), respectively). However, there was a significant increase in the mean pulmonary artery pressure (MPAP; 20 +/- 0.8 vs 25 +/- 1.6 and 18 +/- 1.3 vs 25 +/- 1.6 mmHg, respectively; p < 0.05) and pulmonary vascular resistance index (IRVP; 194 +/- 11 vs 272 +/- 21 and 206 +/- 32 vs 307 +/- 42 dyn x cm-5m(-2), respectively; p < 0.05). These results show that bupropion alone or in association with nicotine does not markedly affect most hemodynamic parameters of the systemic circulation, although the significant increase in MPAP and IRVP can elevate the pulmonary pressure.
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Brazil.
authors.forename: Maria Ondina
authors.initials: MO
authors.lastname: Paganelli
authors.forename: Luís Cláudio
authors.initials: LC
authors.lastname: Martins
authors.forename: Marco Vinícius
authors.initials: MV
authors.lastname: Chaud
authors.forename: Sílvia Elaine
authors.initials: SE
authors.lastname: Ferreira-Melo
authors.forename: Maricene
authors.initials: M
authors.lastname: Sabha
authors.forename: Joaquim Francisco
authors.initials: JF
authors.lastname: do Prado
authors.forename: Stephen
authors.initials: S
authors.lastname: Hyslop
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Tanus-Santos
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno
mesh_terms: D000758:Anesthesia; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D016642:Bupropion / Q000494:pharmacology*; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D016540:Smoking Cessation
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D009538:Nicotine