title: Non-invasive determination of zero-pressure geometry of arterial aneurysms.
abstract: Arterial aneurysms are in a pre-deformed state in vivo under non-zero pressure. The ability to determine their zero pressure geometry may help in improving accuracy of determination of stress distribution and reverse estimation of material properties from dynamic imaging data. An approximate method to recover the zero pressure geometry of the AAA is proposed. This method is motivated by the observation that the patterns in displacement field for a given AAA are strikingly consistent in an AAA under all physiological pressures. The basic principle is to leverage this observation to iteratively identify the geometry that when subjected to the in vivo pressure, will recover the geometry reconstructed from in vivo imaging. The methodology is demonstrated and validated using patient-specific AAA models.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA. ml-raghavan@uiowa.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Raghavan
authors.forename: Baoshun
authors.initials: B
authors.lastname: Ma
authors.forename: Mark F
authors.initials: MF
authors.lastname: Fillinger
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000473:pathology* / Q000503:physiopathology*; D001794:Blood Pressure; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D013314:Stress, Mechanical