title: Towards the development of a pediatric ventricular assist device.
abstract: The very limited options available to treat ventricular failure in children with congenital and acquired heart diseases have motivated the development of a pediatric ventricular assist device at the University of Pittsburgh (UoP) and University of Pittsburgh Medical Center (UPMC). Our effort involves a consortium consisting of UoP, Children's Hospital of Pittsburgh (CHP), Carnegie Mellon University, World Heart Corporation, and LaunchPoint Technologies, Inc. The overall aim of our program is to develop a highly reliable, biocompatible ventricular assist device (VAD) for chronic support (6 months) of the unique and high-risk population of children between 3 and 15 kg (patients from birth to 2 years of age). The innovative pediatric ventricular assist device we are developing is based on a miniature mixed flow turbodynamic pump featuring magnetic levitation, to assure minimal blood trauma and risk of thrombosis. This review article discusses the limitations of current pediatric cardiac assist treatment options and the work to date by our consortium toward the development of a pediatric VAD.
authors.affiliation: Department of Bioengineering & McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. borovetzhs@upmc.edu
authors.forename: Harvey S
authors.initials: HS
authors.lastname: Borovetz
authors.forename: Stephen
authors.initials: S
authors.lastname: Badylak
authors.forename: J Robert
authors.initials: JR
authors.lastname: Boston
authors.forename: Carl
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authors.lastname: Johnson
authors.forename: Robert
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authors.lastname: Kormos
authors.forename: Marina V
authors.initials: MV
authors.lastname: Kameneva
authors.forename: Marwan
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authors.lastname: Simaan
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Snyder
authors.forename: Hiro
authors.initials: H
authors.lastname: Tsukui
authors.forename: William R
authors.initials: WR
authors.lastname: Wagner
authors.forename: Joshua
authors.initials: J
authors.lastname: Woolley
authors.forename: James
authors.initials: J
authors.lastname: Antaki
authors.forename: Chenguang
authors.initials: C
authors.lastname: Diao
authors.forename: Stijn
authors.initials: S
authors.lastname: Vandenberghe
authors.forename: Bradley
authors.initials: B
authors.lastname: Keller
authors.forename: Victor
authors.initials: V
authors.lastname: Morell
authors.forename: Peter
authors.initials: P
authors.lastname: Wearden
authors.forename: Steven
authors.initials: S
authors.lastname: Webber
authors.forename: Jeff
authors.initials: J
authors.lastname: Gardiner
authors.forename: Chung M
authors.initials: CM
authors.lastname: Li
authors.forename: Dave
authors.initials: D
authors.lastname: Paden
authors.forename: Bradley
authors.initials: B
authors.lastname: Paden
authors.forename: Shaun
authors.initials: S
authors.lastname: Snyder
authors.forename: Jingchun
authors.initials: J
authors.lastname: Wu
authors.forename: Gill
authors.initials: G
authors.lastname: Bearnson
authors.forename: John A
authors.initials: JA
authors.lastname: Hawkins
authors.forename: Gordon
authors.initials: G
authors.lastname: Jacobs
authors.forename: John
authors.initials: J
authors.lastname: Kirk
authors.forename: Pratap
authors.initials: P
authors.lastname: Khanwilkar
authors.forename: Peter C
authors.initials: PC
authors.lastname: Kouretas
authors.forename: James
authors.initials: J
authors.lastname: Long
authors.forename: R E
authors.initials: RE
authors.lastname: Shaddy
mesh_terms: D001672:Biocompatible Materials; D002648:Child; D015199:Extracorporeal Membrane Oxygenation; D006353:Heart-Assist Devices; D006801:Humans
chemical_list: D001672:Biocompatible Materials