Molecular mechanism of the life and death of the osteoclast.
The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.
Tanaka
Sakae
S
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. TANAKAS-ORT@h.u-tokyo.ac.jp
Miyazaki
Tsuyoshi
T
Fukuda
Akira
A
Akiyama
Toru
T
Kadono
Yuho
Y
Wakeyama
Hidetoshi
H
Kono
Shinjiro
S
Hoshikawa
Shinya
S
Nakamura
Masaki
M
Ohshima
Yasushi
Y
Hikita
Atsuhiko
A
Nakamura
Ichiro
I
Nakamura
Kozo
K
D000818:Animals; D017209:Apoptosis; D016923:Cell Death; D002470:Cell Survival; D006706:Homeostasis; D006801:Humans; D010010:Osteoclasts / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction