Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release.
In this paper we present the formulation, preparation and characterization of new polymeric composite materials containing a nano-hybrid to be used for the controlled molecular delivery of an anti-inflammatory molecule, Diclofenac. The nano-hybrid consists of a layer of double hydroxide of an Mg-Al hydrotalcite type, in which we replaced the chloride anions present in the host galleries with Diclofenac anions by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15 mm thickness. The composite materials were analyzed by X-ray diffractometry, thermogravimetry and for their mechanical properties, and showed properties even better than those for the pristine polymer. The release process of the anti-inflammatory molecules was very interesting and promising for tuneable drug delivery. It consists of two stages: a first stage, very rapid as a burst in which a small fraction of the drug is released, and of a second stage that is much slower, extending for longer and longer periods. The parameters influencing the drug release were individuated and discussed.
Sammartino
G
G
Department of Oral and Maxillofacial Sciences, University of Federico II, Napoli, Italy. gilberto.sammartino@unina.it
Marenzi
G
G
Tammaro
L
L
Bolognese
A
A
Calignano
A
A
Costantino
U
U
Califano
L
L
Mastrangelo
F
F
Tetè
S
S
Vittoria
V
V
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001696:Biomechanical Phenomena; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry; D053761:Nanocomposites / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011108:Polymers; D004008:Diclofenac