title: Interleukins 2, 6, and 8 levels in human gingival sulcus during orthodontic treatment.
abstract: BACKGROUND
  The aims of this study were to determine levels of interleukins 2, 6, and 8 during tooth movement, and test whether they differ from each other with leveling and distalization forces used in various treatment stages of standard orthodontic therapy.
  
  
  METHODS
  Fifteen patients (9 female, 6 male; ages, 15-19 years; mean age, 16.7 +/- 2.3 years) participated in this study. Each underwent a session of professional oral hygiene and received oral hygiene instructions. Two months later, a fixed orthodontic appliance was placed. The patients were seen at baseline, at days 7 and 21, and as the teeth were leveled. Records of the baseline scores for the distalization forces were taken at the sixth month. Scores of days 7 and 21 after 6 months of the distalization treatment were also recorded.
  
  
  RESULTS
  Increases were seen in the volume of gingival crevicular fluid and the concentrations of interleukins 2, 6, and 8.
  
  
  CONCLUSIONS
  Leveling and distalization of the teeth evoke increases in interleukins 2, 6, and 8 levels in the periodontal tissues that can be detected in gingival crevicular fluid.
authors.affiliation: School of Dentistry, Dicle University, Diyarbakir, Turkey.
authors.forename: Güvenç
authors.initials: G
authors.lastname: Başaran
authors.forename: Törün
authors.initials: T
authors.lastname: Ozer
authors.forename: Filiz Acun
authors.initials: FA
authors.lastname: Kaya
authors.forename: Orhan
authors.initials: O
authors.lastname: Hamamci
mesh_terms: D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000378:metabolism; D003799:Dental Stress Analysis; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis / Q000378:metabolism*; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism*; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010513:Periodontal Ligament / Q000378:metabolism; D018709:Statistics, Nonparametric; D014087:Tooth Movement Techniques
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8