title: Distribution and impact of lymph node metastases in oropharyngeal cancer.
abstract: CONCLUSIONS
  In the treatment of oropharyngeal cancers, possible metastases to retropharyngeal lymph nodes (RPLNs) should be taken into account, especially in tumors arising in the lateral wall and/or posterior wall. Patients with multiple positive neck nodes must have intensified adjuvant therapy, especially when they have extracapsular spread (ECS).
  
  
  OBJECTIVE
  To develop optimal treatment strategies for oropharyngeal cancers, we retrospectively analyzed the lymph node metastases of oropharyngeal squamous cell carcinoma.
  
  
  METHODS
  Between 1988 and 2003, 77 patients with previously untreated oropharyngeal squamous cell carcinoma underwent neck dissections.
  
  
  RESULTS
  Among the patients with tumor arising in the lateral wall or posterior wall, retropharyngeal nodes were involved in 29% (11/38), while RPLN metastasis was not observed in patients with tumors arising in the superior wall or anterior wall. The survival rate of patients with two or fewer positive lymph nodes was significantly better than that of patients with three or more positive lymph nodes (p < 0.05). The survival rate of the patients who had ECS was significantly worse than that of the patients who had lymph node metastases but not ECS (p < 0.05). There was no significant difference between the survival rates of the patients with and without RPLN metastases.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Hospital, Kobe, Japan.
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Miki
authors.initials: M
authors.lastname: Saitoh
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohtsuki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ishida
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Makino
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Amatsu
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nibu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate