title: Targeting adiponectin for cardioprotection.
abstract: Adiponectin is an adipose tissue-derived plasma protein which has a reduced concentration in subjects with obesity-related diseases. Adiponectin has antidiabetic and anti-inflammatory characteristics, which lead to beneficial actions on various obesity-linked complications. Recent experimental findings have shown that adiponectin contributes to protection against cardiac remodelling after pressure overload and cardiac injury following ischaemia-reperfusion. Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions.
authors.affiliation: Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Kenneth
authors.initials: K
authors.lastname: Walsh
mesh_terms: D052242:Adiponectin / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D006801:Humans
chemical_list: D052242:Adiponectin; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents