title: Uridine supplementation enhances hepatic mitochondrial function in thymidine-analogue treated HIV-infected patients.
abstract: Supplementation with uridine offers the possibility of a new and promising approach to nucleoside analogue reverse transcriptase inhibitor-associated mitochondrial toxicity. We investigated the metabolic effects of short-course treatment with the uridine-enriched food supplement NucleomaxX on hepatic mitochondrial function in thymidine-analogue treated HIV-infected patients. Mitochondrial function was assessed by a recently introduced non-invasive C-methionine breath test. NucleomaxX supplementation enhanced mitochondrial decarboxylation function reversibly but reproducibly in all patients. Repeated administration in shorter treatment intervals may maintain this effect.
authors.affiliation: Department of Internal Medicine, St. Josef-Hospital, University of Bochum, Germany. mbanasch@gmx.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Banasch
authors.forename: Oliver
authors.initials: O
authors.lastname: Goetze
authors.forename: Kathy
authors.initials: K
authors.lastname: Knyhala
authors.forename: Anja
authors.initials: A
authors.lastname: Potthoff
authors.forename: Renate
authors.initials: R
authors.lastname: Schlottmann
authors.forename: Monika A
authors.initials: MA
authors.lastname: Kwiatek
authors.forename: Kerem
authors.initials: K
authors.lastname: Bulut
authors.forename: Frank
authors.initials: F
authors.lastname: Schmitz
authors.forename: Wolfgang E
authors.initials: WE
authors.lastname: Schmidt
authors.forename: Norbert H
authors.initials: NH
authors.lastname: Brockmeyer
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D001944:Breath Tests / Q000379:methods; D019587:Dietary Supplements; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D014529:Uridine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D014529:Uridine