A general route to protected quaternary alpha-amino acids from beta-amino alcohols via a stereocontrolled radical approach.
A radical-based approach facilitates the highly stereocontrolled functionalisation of beta-amino alcohols, opening up a new, generally applicable methodology for the preparation of quaternary alpha-amino acids.
Wood
Mark E
ME
School of Biosciences (originally Department of Chemistry), University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UKEX4 4QD. m.e.wood@exeter.ac.uk
Penny
Mark J
MJ
Steere
Jenny S
JS
Horton
Peter N
PN
Light
Mark E
ME
Hursthouse
Michael B
MB
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D000605:Amino Alcohols