A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of pain following laparoscopy and dye.
The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. Women received either 15 ml of 0.9% saline (n= 42) or 15 ml of 0.5% bupivacaine (n= 43), which was instilled intraperitoneally. Pain and nausea scores were recorded on a visual analogue scale (VAS). Pain perception was no different in the bupivacaine group compared with the control group with median values of VAS at 2 hours (18, 19; P= 0.8), 6 hours (21, 22; P= 0.5), 12 hours (19, 25; P= 0.8), 24 hours (27, 27; P= 0.9) and 48 hours (21, 13; P= 0.26). Women in the bupivacaine group were less nauseated than controls in the immediate postoperative period (with median VAS scores of 0, 8; P value = 0.03 at 2 hours and 0, 7; P= 0.01 at 6 hours).
Sripada
S
S
Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UK. ogy302@abdn.ac.uk
Roy
S
S
Mathur
M
M
Hamilton
M
M
Cranfield
K
K
Bhattacharya
S
S
D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D004396:Coloring Agents; D004311:Double-Blind Method; D004333:Drug Administration Routes; D005184:Fallopian Tube Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D010535:Laparoscopy; D008751:Methylene Blue; D010149:Postoperative Pain / Q000517:prevention & control*; D010388:Pelvis; D011446:Prospective Studies
D000779:Anesthetics, Local; D004396:Coloring Agents; D008751:Methylene Blue; D002045:Bupivacaine