[Expression of integrin-linked kinase is closely correlated with laryngeal squamous cell carcinomas].
OBJECTIVE
To study whether Integrin linked kinase (ILK) is involved in the development and progression of laryngeal squamous cell carcinomas (LSCC).


METHODS
We examined the expression of ILK in 64 LSCC (LSCC group) and 10 normal laryngeal mucosa (control group) using reverse transcription polymerase chain reaction (RT-PCR) and analyzed the relationship with clinic pathological parameters.


RESULTS
The expression of ILK mRNA was significantly higher in 64 LSCC tissue (0. 644 +/- 0. 098) than in normal laryngeal mucosa tissues (0.032 +/- 0.026, P <0.05). The expression of ILK mRNA in LSCC with the metastasis of lymph nodes (0. 867 +/- 0.247) was significantly higher than those without metastasis (0.389 +/- 0.199, P <0.05). With the development of clinical T-stages of LSCC, the expression of ILK mRNA in LSCC increases. There was no significant difference between different clinical stage groups (P > 0.05).


CONCLUSIONS
These results suggest that ILK may participate not only in LSCC but also in invasion and metastasis of LSCC. ILK might be a novel molecular marker for prognosticating metastases and prognosis of LSCC.
Wu
Changzhu
C
Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Beijing, China. wuchangzhu@sina.com
Zhai
Ning
N
Guan
Chao
C
Ji
Wenyu
W
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D000099200:Scaffold Protein ILK
D017346:Protein Serine-Threonine Kinases; D012333:RNA, Messenger; D000099200:Scaffold Protein ILK