Investigation of soft long chain quaternary ammonium compounds as co-factors to enhance in vitro gene delivery.
The effect of soft long chain quaternary ammonium antibacterial agents on the in vitro gene delivery of a luciferase plasmid to COS-1 cell lines was investigated. Low concentrations of these compounds could be used to enhance gene delivery with Lipofectamine Plus.
Másson
M
M
Faculty of Pharmacy, University of Iceland, Reykjavik.
Benediktsson
T
T
Thorsteinsson
T
T
Loftsson
T
T
D000818:Animals; D019556:COS Cells; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004247:DNA / Q000008:administration & dosage / Q000235:genetics; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014162:Transfection
D000644:Quaternary Ammonium Compounds; D004247:DNA