Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
A new cyclic nonapeptide, segetalin F, has been isolated from the seeds of Vaccaria segetalis and the structure including absolute stereochemistry was elucidated by using 2D NMR and chemical means. A series of segetalins showed a vasorelaxant activity against norepinephrine (NE)-induced contractions of rat aorta.
Morita
Hiroshi
H
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. moritah@hoshi.ac.jp
Eda
Michiko
M
Iizuka
Toru
T
Hirasawa
Yusuke
Y
Sekiguchi
Mitsuhiro
M
Yun
Young Sook
YS
Itokawa
Hideji
H
Takeya
Koichi
K
D000818:Animals; D001011:Aorta / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012639:Seeds / Q000737:chemistry; D031245:Vaccaria / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects*
D010456:Peptides, Cyclic; D010936:Plant Extracts; C514047:segetalin F