title: [A study of the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome and obesity and patients with normal body mass].
abstract: OBJECTIVE
  To explore the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and obesity and patients with normal body mass.
  
  
  METHODS
  Polysomnography (PSG) was performed in 53 patients with OSAHS and in 41 simple obesity and in 62 patients with normal body mass. The level of serum leptin was detected by radioimmunoassay. The stature, weight, neck collar, hip circumference, waistline were measured.
  
  
  RESULTS
  (1) Serum leptin level in patients with OSAHS and obesity was higher than patients with normal body mass. At the same time, serum leptin level in patients with OSAHS was higher than obesity ( P < 0.05). (2) Serum leptin levels were positive significantly correlated with BMI in both OSAHS patients and simple obesity, but only the leptin level in patients with OSAHS was significantly correlated with apnea and hypopnea index (AHI) and proportion of neck circumference and waist-hip ratio (WHR).
  
  
  CONCLUSIONS
  The rise of the serum leptin level in obesity was resisted of leptin. The serum leptin level of patients with OSAHS correlated with AHI shows that OSAHS maybe one reason of arising serum leptin's rising. Leptin could stimulate aspirator centrum.
authors.affiliation: Department of Otolaryngology, the 105th Hospital of the PLA, Hefei, China. wangsg105@sina.com
authors.forename: Shengguo
authors.initials: S
authors.lastname: Wang
authors.forename: Benzhong
authors.initials: B
authors.lastname: Zhou
authors.forename: Jingwu
authors.initials: J
authors.lastname: Sun
authors.forename: Weiqing
authors.initials: W
authors.lastname: Xu
authors.forename: Zhikui
authors.initials: Z
authors.lastname: Jiang
authors.forename: Lan
authors.initials: L
authors.lastname: Lan
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications
chemical_list: D020738:Leptin