Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.
In the present study, a local inflammatory response in white adipose tissue from the nonobese HSL-null mouse model is demonstrated. The protein levels of several well-known markers of inflammation, like TNFalpha and ferritin HC, were highly increased and accompanied by an activation of NFkappaB. A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells.
Hansson
Ola
O
Department of Experimental Medical Science, Lund University, BMC C11, SE-221 84 Lund, Sweden. Ola.Hansson@med.lu.se
Ström
Kristoffer
K
Güner
Nuray
N
Wierup
Nils
N
Sundler
Frank
F
Höglund
Peter
P
Holm
Cecilia
C
D000273:Adipose Tissue / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D003433:Crosses, Genetic; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D005695:Galactosephosphates / Q000378:metabolism; D007150:Immunohistochemistry; D007249:Inflammation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010449:Peptide Mapping; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D012697:Serine Endopeptidases / Q000032:analysis; D002787:Sterol Esterase / Q000235:genetics / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004041:Dietary Fats; D005695:Galactosephosphates; D008840:Microfilament Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D020543:Proteome; D014409:Tumor Necrosis Factor-alpha; C097493:galactitol 3-phosphate; C483826:Capg protein, mouse; D002787:Sterol Esterase; D012697:Serine Endopeptidases; C066932:mast cell protease 4