title: Third order harmonic imaging for biological tissues using three phase-coded pulses.
abstract: Compared to the fundamental and the second harmonic imaging, the third harmonic imaging shows significant improvements in image quality due to the better resolution, but it is degraded by the lower sound pressure and signal-to-noise ratio (SNR). In this study, a phase-coded pulse technique is proposed to selectively enhance the sound pressure of the third harmonic by 9.5 dB whereas the fundamental and the second harmonic components are efficiently suppressed and SNR is also increased by 4.7 dB. Based on the solution of the KZK nonlinear equation, the axial and lateral beam profiles of harmonics radiated from a planar piston transducer were theoretically simulated and experimentally examined. Finally, the third harmonic images using this technique were performed for several biological tissues and compared with the images obtained by the fundamental and the second harmonic imaging. Results demonstrate that the phase-coded pulse technique yields a dramatically cleaner and sharper contrast image.
authors.affiliation: State Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Ma
authors.forename: Xiufen
authors.initials: X
authors.lastname: Gong
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*