[Biochemical properties and functional role of ubiquinone (CoQ). Aspects of practical use].
In addition to well known function of ubiquinone as a component of mitochondrial electron-transport chain and antioxidant, the latest research data that evidence for its function as a regulator of the processes connected with gene expression, signal transduction, including regulation of apoptosis are considered in this review. We also discuss practical aspects of use of ubiquinone for prophylaxis and treatment of cardiovascular, oncological diseases, pathologies of immune system, disorders caused by the effect of ionizing radiation.
Donchenko
H V
HV
Kuchmenko
O B
OB
Petukhov
D M
DM
D000818:Animals; D017209:Apoptosis; D002462:Cell Membrane / Q000378:metabolism; D004579:Electron Transport; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D015394:Molecular Structure; D014451:Ubiquinone / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use
D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D014451:Ubiquinone