title: Versican degradation and vascular disease.
abstract: Versican is an abundant proteoglycan in the blood vessel wall that is increased after vascular injury and accumulates in advanced atherosclerotic plaques. Versican is a large molecule with domains that mediate binding to cytokines, enzymes, lipoproteins, other extracellular matrix molecules, and signaling receptors. There is evidence that versican exists in the normal, as well as the diseased, vessel wall as discrete fragments, which represent these functional domains. We review the literature on versican degradation in vascular tissue and the function of versican domains, all of which suggest that proteolytic modification of versican may have physiologic as well as pathologic implications for the vascular system.
authors.affiliation: Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Department of Surgery, Seattle, WA 98109-4714, USA. rkenagy@u.washington.edu
authors.forename: Richard D
authors.initials: RD
authors.lastname: Kenagy
authors.forename: Anna H
authors.initials: AH
authors.lastname: Plaas
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Wight
mesh_terms: D000818:Animals; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology; D014652:Vascular Diseases / Q000378:metabolism* / Q000473:pathology; D053675:Versicans / Q000378:metabolism*
chemical_list: D053675:Versicans