Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial.
BACKGROUND
The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.


RESULTS
We randomly allocated 96 patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion into 4 groups. Eighty-two patients completed 6-month follow-up; AMI cell infusion (n=25), AMI control (n=25), OMI cell infusion (n=16), and OMI control group (n=16). In cell infusion groups, PBSCs were mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion. The AMI cell infusion group showed a significant additive improvement in left ventricular ejection fraction (LVEF) and remodeling compared with controls (change of LVEF: +5.1+/-9.1% versus -0.2+/-8.6%, P<0.05; change of end-systolic volume: -5.4+/-17.0 mL versus 6.5+/-21.9 mL, P<0.05). In OMI patients, however, there was no significant change of LVEF and ventricular remodeling in spite of significant improvement of coronary flow reserve after cell infusion. G-CSF-based cell therapy did not aggravate neointimal growth with DES implantation.


CONCLUSIONS
Intracoronary infusion of mobilized PBSCs with G-CSF improves LVEF and remodeling in patients with AMI but is less definite in patients with OMI. G-CSF-based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis.
Kang
Hyun-Jae
HJ
Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.
Lee
Hae-Young
HY
Na
Sang-Hoon
SH
Chang
Sung-A
SA
Park
Kyung-Woo
KW
Kim
Hyung-Kwan
HK
Kim
Song-Yi
SY
Chang
Ho-Joon
HJ
Lee
Whal
W
Kang
Won Jun
WJ
Koo
Bon-Kwon
BK
Kim
Yong-Jin
YJ
Lee
Dong Soo
DS
Sohn
Dae-Won
DW
Han
Kyou-Sup
KS
Oh
Byung-Hee
BH
Park
Young-Bae
YB
Kim
Hyo-Soo
HS
D000208:Acute Disease; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D023903:Coronary Restenosis / Q000517:prevention & control*; D003331:Coronary Vessels; D004343:Drug Implants; D018618:Echocardiography, Doppler, Color; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D006965:Hyperplasia; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D015607:Stents; D013318:Stroke Volume; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
D004343:Drug Implants; D016179:Granulocyte Colony-Stimulating Factor