title: Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk.
abstract: The authors present a case where the simultaneous administration of 6-mercaptopurine (6-MP) and cow's milk during maintenance treatment for acute lymphoblastic leukemia led to elevated full blood counts resistant to increasing doses of chemotherapy. The blood counts returned to the expected range after milk intake with chemotherapy was discontinued.
authors.affiliation: Paediatric Department, Hillingdon Hospital, Uxbridge, Middlesex, UK. katsofkat@hotmail.com
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Sofianou-Katsoulis
authors.forename: Gulamabbas
authors.initials: G
authors.lastname: Khakoo
authors.forename: Richard
authors.initials: R
authors.lastname: Kaczmarski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001682:Biological Availability; D002675:Child, Preschool; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008727:Methotrexate / Q000627:therapeutic use; D008892:Milk; D009504:Neutrophils / Q000166:cytology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D015122:Mercaptopurine; D008727:Methotrexate