title: ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins.
abstract: ScanProsite--http://www.expasy.org/tools/scanprosite/--is a new and improved version of the web-based tool for detecting PROSITE signature matches in protein sequences. For a number of PROSITE profiles, the tool now makes use of ProRules--context-dependent annotation templates--to detect functional and structural intra-domain residues. The detection of those features enhances the power of function prediction based on profiles. Both user-defined sequences and sequences from the UniProt Knowledgebase can be matched against custom patterns, or against PROSITE signatures. To improve response times, matches of sequences from UniProtKB against PROSITE signatures are now retrieved from a pre-computed match database. Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results.
authors.affiliation: Swiss Institute of Bioinformatics, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland. ecastro@isb-sib.ch
authors.forename: Edouard
authors.initials: E
authors.lastname: de Castro
authors.forename: Christian J A
authors.initials: CJ
authors.lastname: Sigrist
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gattiker
authors.forename: Virginie
authors.initials: V
authors.lastname: Bulliard
authors.forename: Petra S
authors.initials: PS
authors.lastname: Langendijk-Genevaux
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gasteiger
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hulo
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D030562:Databases, Protein; D020407:Internet; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D012984:Software; D014584:User-Computer Interface
chemical_list: D000596:Amino Acids; D011506:Proteins