The elution of poly (vinyl alcohol) from a contact lens: the realization of a time release moisturizing agent/artificial tear.
The use of a contact lens as a polymeric delivery vehicle is presented. Specifically, the elution of nonfunctionalized poly (vinyl alcohol) (PVA) from nelfilcon A hydrogel lenses is presented as a model of delivering polymeric active agents to the eye. High molecular weight nonfunctionalized PVA is added to the lens matrix for later release into the tears. This is made possible by photo crosslinking a macromer species in lieu of monomeric polymerization. Consistent near zero order release of 0.062% (wt/wt) was demonstrated in vitro over a 20-h period. The result is a new contact lens device based on the slow release of PVA. In vivo results demonstrate that this product improves the wearing comfort of this type of contact lens and acts as a model basis for drug delivery.
Winterton
Lynn C
LC
CIBA Vision Corporation, 11460 Johns Creek Parkway, Duluth, Georgia 30097-1556, USA. Lynn.winterton@cibavision.com
Lally
John M
JM
Sentell
Karen B
KB
Chapoy
L Lawrence
LL
D001672:Biocompatible Materials / Q000493:pharmacokinetics; D003263:Contact Lenses, Hydrophilic; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels; D066298:In Vitro Techniques; D008422:Materials Testing; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics*; D011446:Prospective Studies
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D020100:Hydrogels; D009883:Ophthalmic Solutions; D011142:Polyvinyl Alcohol