title: Haemorrhagic acute disseminated encephalomyelitis: an unusual case of blindness in an HIV-infected patient.
abstract: Acute disseminated encephalomyelitis (ADEM) is a monophasic, polysymptomatic, immune-mediated demyelinating disorder involving central nervous system (CNS) white matter. It is usually seen in association with exanthematous viral illnesses, systemic infections or vaccinations. The haemorrhagic form of ADEM is rarer and follows a more fulminant course. We describe a case of haemorrhagic ADEM in an HIV-infected patient presenting solely with acute onset bilateral blindness and normal retina. ADEM was diagnosed from clinical, laboratory and radiological findings. Although ADEM has been seen with HIV seroconversion illness and in chronic infection, the haemorrhagic form has never been reported in association with HIV. Acute onset blindness is extremely rare in HIV-positive patients. A Medline search revealed very few reports. The importance of considering haemorrhagic ADEM as aetiology of blindness in such a scenario is discussed.
authors.affiliation: Department of Genito-urinary Medicine, King's College Hospital, London, UK. rcmalini@yahoo.co.uk
authors.forename: Malini
authors.initials: M
authors.lastname: Raychaudhuri
authors.forename: Thushan
authors.initials: T
authors.lastname: de Silva
authors.forename: Stephen
authors.initials: S
authors.lastname: Connor
authors.forename: Mary
authors.initials: M
authors.lastname: Poulton
mesh_terms: D000328:Adult; D001766:Blindness / Q000175:diagnosis / Q000209:etiology*; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging