Effects of griseoviridin and viridogrisein against swine dysentery in experimental infection by using mice and pigs.
Griseoviridin, a known antibiotic produced by Streptomyces cacaoi subsp. cacaoi, was found to be active against Brachyspira hyodysenteriae--the bacterium causing swine dysentery. An in vitro synergism is observed when it is used in combination with viridogrisein--a simultaneously produced antibiotic. In mouse experiments, the effect of griseoviridin alone was less than that of lincomycin--a commercially available swine dysentery medication. However, a 1:1 mixture of griseoviridin and viridogrisein revealed a noticeable synergistic effect. In an evaluation using pigs artificially infected with B. hyodysenteriae, a large difference was not observed between the effect of griseoviridin alone and that in combination with viridogrisein. Nevertheless, griseoviridin alone exhibited a therapeutic effect superior to that of lincomycin.
Asano
Toshihiko
T
Research Center, Astellas Pharma Inc., Ibaraki, Japan.
Adachi
Yoshikazu
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004403:Dysentery / Q000188:drug therapy / Q000662:veterinary*; D008034:Lincomycin / Q000494:pharmacology; D018942:Macrolides / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013047:Specific Pathogen-Free Organisms; D013144:Spirochaetales / Q000187:drug effects; D013145:Spirochaetales Infections / Q000188:drug therapy*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014769:Virginiamycin / Q000494:pharmacology; D047630:Depsipeptides
D000900:Anti-Bacterial Agents; D008034:Lincomycin; D018942:Macrolides; D010455:Peptides; D014769:Virginiamycin; C010583:griseoviridin; C004910:etamycin; D047630:Depsipeptides