A new efficient route for the formation of quinoxaline N-oxides and N,N'-dioxides using HOF.CH3CN.
HOF.CH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N'-dioxides in very good yields under mild conditions and short reaction times.
Carmeli
Mira
M
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
Rozen
Shlomo
S
D000097:Acetonitriles / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010087:Oxides / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
D000097:Acetonitriles; D010087:Oxides; D011810:Quinoxalines; D005461:Fluorine; D006859:Hydrogen; C003282:quindoxin