Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position.
Novel oligonucleotides bearing a polyamine-intercalator conjugate modified at the terminal or the internal position were reported. These modified oligonucleotides showed duplex-stabilization effect, and the thermodynamic analysis and the salt concentration dependency of the duplex stability revealed that the polyamine moiety also acted as the duplex stabilizer by neutralization of the phosphate negative charge.
Moriguchi
Tomohisa
T
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu, Gunma, Japan.
Sekiguchi
Hirokazu
H
Tachibana
Makoto
M
Shinozuka
Kazuo
K
D001483:Base Sequence; D007364:Intercalating Agents / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D007364:Intercalating Agents; D009841:Oligonucleotides; D011073:Polyamines