title: Surgery for hepatocellular carcinoma arising in hereditary hemochromatosis.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is a well-known complication of hereditary hemochromatosis. The benefit of surgical therapy in this clinical entity is not well documented. The purpose of this study was to evaluate the outcome of such patients both in our own experience as well as in the published literature.
  
  
  METHODS
  320 patients with a diagnosis of HCC were evaluated at our institution to undergo either surgical resection (n = 262) or liver transplantation (n = 58) during the 4- year period from January 2001 to December 2004. We identified 5 patients with HCC arising in the setting of hemochromatosis. A literature search was performed to estimate resectability rates as well as outcomes after liver transplantation for HCC arising in hemochromatosis.
  
  
  RESULTS
  HCC was multifocal in 4 instances and solitary in 1 case. The liver was cirrhotic in all but 1 case. Three patients underwent an exploratory laparotomy, 1 an exploratory laparoscopy, and 1 underwent transplantation. HCC was unresectable in all cases. The patient with a solitary tumor and cirrhosis underwent 5 sessions of transarterial chemoembolization and is alive 37 months after surgical exploration. The 3 patients with multifocal tumors who underwent exploratory laparotomies died within 6 months after the intervention. The fifth patient who underwent a deceased donor split liver transplantation for multifocal tumor is alive without recurrence 3 years after transplantation. These results are similar to those in the literature that concur with the low resectability rate and the favorable outcome after liver transplantation.
  
  
  CONCLUSIONS
  Resectability rates of HCCs arising in hemochromatosis are extremely low, given that tumors are usually multifocal and the livers cirrhotic in the majority of the instances. Early detection of hemochromatosis as well as intensive tumor screening of cirrhotic patients with hemochromatosis could possibly optimize the role of surgery or accelerate the decision to proceed with liver transplantation.
authors.affiliation: Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany. georgios.sotiropoulos@uni-essen.de
authors.forename: Georgios C
authors.initials: GC
authors.lastname: Sotiropoulos
authors.forename: Ernesto P
authors.initials: EP
authors.lastname: Molmenti
authors.forename: Hauke
authors.initials: H
authors.lastname: Lang
authors.forename: Susanne
authors.initials: S
authors.lastname: Beckebaum
authors.forename: Gernot M
authors.initials: GM
authors.lastname: Kaiser
authors.forename: Eirini I
authors.initials: EI
authors.lastname: Brokalaki
authors.forename: Andrea
authors.initials: A
authors.lastname: Frilling
authors.forename: Massimo
authors.initials: M
authors.lastname: Malagó
authors.forename: Markus
authors.initials: M
authors.lastname: Neuhauser
authors.forename: Christoph E
authors.initials: CE
authors.lastname: Broelsch
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000601:surgery*; D005260:Female; D006432:Hemochromatosis / Q000150:complications*; D006801:Humans; D008099:Liver / Q000601:surgery*; D008113:Liver Neoplasms / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged