[Tofisopam and melatonin attenuate the reorganization of circadian locomotor rhythm in rats under injection-induced stress conditions].
Repeated saline injections induce reorganization of the circadian locomotor rhythm in rats, which is manifested by increased amplitude, enhanced instability of the acrophase, and changed spectral characteristics. The benzodiazepine anxiolytic tofisopam (grandaxin, 10 mg/kg) and the pineal hormone melatonin (0.1 mg/kg) prevented the stress-induced changes in the circadian rhythm. The hormone exhibited a more optimal chronotropic activity than grandaxin.
Arushunian
E B
EB
Popov
A V
AV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001569:Benzodiazepines / Q000008:administration & dosage*; D002940:Circadian Rhythm / Q000187:drug effects*; D004359:Drug Therapy, Combination; D008550:Melatonin / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000188:drug therapy* / Q000503:physiopathology
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D008550:Melatonin; C012582:tofisopam