Biodegradable scleral implants as new triamcinolone acetonide delivery systems.
The goal of this study was to develop ocular scleral implants able to release triamcinolone acetonide (TA) overall several months. Scleral discs were manufactured by a compression-molding method using a new synthetic polymer, poly(methylidene malonate) (PMM2.1.2), as matrix. Implants with good mechanical properties adapted for in vivo implantation have been obtained when using high M(w) PMM2.1.2 (100,000 - 150,000 Da) associated with ethoxylated derivatives of stearic acid (Simulsol) or oligomers of methylidene malonate as plasticizer. After implantation in rabbit eyes, scleral implants showed a good ocular biocompatibility. Indeed, the clinical follow-up and ocular inflammation parameters, such as inflammatory cell number and protein content in aqueous humor, demonstrated that implants were well tolerated and did not provoke abnormal inflammation. Implants were able to release significant concentrations of TA in the vitreous and the sclera throughout 5 weeks.
Felt-Baeyens
O
O
Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
Eperon
S
S
Mora
P
P
Limal
D
D
Sagodira
S
S
Breton
P
P
Simonazzi
B
B
Bossy-Nobs
L
L
Guex-Crosier
Y
Y
Gurny
R
R
D020341:Absorbable Implants; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D008422:Materials Testing; D010968:Plasticizers / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry; D011506:Proteins / Q000032:analysis; D011817:Rabbits; D012590:Sclera / Q000378:metabolism; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D014822:Vitreous Body / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008314:Malonates; D010968:Plasticizers; D011095:Polyethylenes; D011506:Proteins; C091414:poly(methylidene malonate) 2.1.2; D014222:Triamcinolone Acetonide