Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies.
The purpose of this study was to investigate myocardial uptake of 123I-metaiodobenzylguanidine (MIBG) in patients with pure autonomic failure (PAF), which has pathologic features in common with idiopathic Parkinson's disease (IPD) and dementia with Lewy bodies (DLB).


METHODS
Six patients with PAF, 130 with IPD, 21 with DLB, 9 with corticobasal degeneration (CBD), 11 with progressive supranuclear palsy (PSP), and 11 with multiple-system atrophy (MSA) underwent myocardial 123I-MIBG scintigraphy, as did 16 control patients.


RESULTS
Resulting heart-to-mediastinum (H/M) ratios were significantly lower in patients with PAF, IPD, or DLB than in patients with CBD, PSP, or MSA and in the controls. H/M ratios were lower for delayed images than for early ones in patients with PAF, IPD, or DLB, whereas the ratios were higher for delayed images in patients with CBD and in the controls.


CONCLUSIONS
Cardiac sympathetic denervation and enhanced washout of 123I-MIBG from sympathetic nerve terminals may develop in parallel in patients with PAF, IPD, or DLB.
Kashihara
Kenichi
K
Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama, Japan. kkashi@kyokuto.or.jp
Ohno
Manabu
M
Kawada
Sanami
S
Okumura
Yoshihiro
Y
D019797:3-Iodobenzylguanidine / Q000494:pharmacology*; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000473:pathology; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D020961:Lewy Body Disease / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine