Mixing and matching during synaptic vesicle endocytosis.
The question of how synapses maintain an active recycling pool of synaptic vesicles to support high-frequency synaptic transmission has been a perplexing and often controversial problem. In this issue of Neuron, Fernandez-Alfonso et al. present data indicating that at least two synaptic vesicle proteins, synaptotagmin 1 and VAMP-2, are present in a large pool on the synaptic and axonal plasma membrane and can interchange with recently exocytosed proteins. These findings suggest that a plasma membrane pool of synaptic vesicle proteins provides a reservoir that can facilitate rapid endocytosis.
Littleton
J Troy
JT
Department of Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D013572:Synaptic Vesicles / Q000378:metabolism / Q000502:physiology*