Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection.
Debiaggi
Maurizia
M
Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Universita di Pavia, via Brambilla, 74, 27100, Pavia, Italy. mdeb@unipv.it
Canducci
Filippo
F
Sampaolo
Michela
M
Marinozzi
Maria Chiara
MC
Parea
Maurizio
M
Terulla
Cristina
C
Colombo
Anna Amelia
AA
Alessandrino
Emilio Paolo
EP
Bragotti
Letizia Zenone
LZ
Arghittu
Milena
M
Goglio
Antonio
A
Migliavacca
Roberta
R
Romero
Egidio
E
Clementi
Massimo
M
D000328:Adult; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D029121:Metapneumovirus / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000821:virology; D011024:Pneumonia, Viral / Q000453:epidemiology* / Q000821:virology; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons
D012367:RNA, Viral