Cell vesiculation and immunopathology: implications in cerebral malaria.
Microparticles are plasma membrane fragments that are generated and released under physiological conditions. They are also released when tissue and/or systemic homeostasis is disrupted. These microparticles display different physiological features of the cells from which they originate. They are detected in some pathological conditions, but rarely suspected of participating in the disease's pathogenesis. In the present review, we summarise data about the production of the microparticles, their biological significance and potential role during microorganism-driven processes, especially in cerebral malaria.
Coltel
Nicolas
N
CNRS UMR 6020-Immunopathology Group, Faculty of Medicine-IFR48, 27, bd. Jean Moulin, F-13385 Marseille Cedex 5, France.
Combes
Valéry
V
Wassmer
Samuel C
SC
Chimini
Giovanna
G
Grau
Georges E
GE
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007239:Infections / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D016779:Malaria, Cerebral / Q000276:immunology* / Q000473:pathology*; D008954:Models, Biological