[An analysis of islet beta-cell function in hyperuricemia].
OBJECTIVE
To study the islet beta-cell function in patients with simple hyperuricemia (HUA) and to explore the relationship between the level of serum uric acid and insulin resistance.


METHODS
The first and second phases of insulin secretion of beta-cell were observed after L-arginine stimulation test and oral glucose tolerance test (OGTT) in 56 hyperuricemic patients and 40 healthy controls.


RESULTS
The peak value of insulin secretion in both groups was at the 2nd min and it began to decrease at the 4th min after L-arginine stimulation. However, the peak value in the HUA group was significantly higher than that in the control group (t = 3.71, P < 0.01). Fasting plasma insulin, 120-min plasma glucose and 120-min insulin during OGTT as well as modified beta-cell function index and Homa-insulin resistance (HOMA-IR) in the HUA group were obviously higher than those in the control group (t = 2.46-5.56, P < 0.05, P < 0.01). Multiple step regression analysis showed that serum uric acid was positively correlated with low density lipoprotein-cholesterol, HOMA-IR, male sex, mean arterial pressure and creatinine (t = 2.15-3.60, P < 0.05).


CONCLUSIONS
The islet beta-cell function in hyperuricemic patients increases compensatively and the serum uric acid level is positively correlated with insulin resistance.
Jia
Shao-dan
SD
Department of Endocrinology, Qingdao People's Hospital, Qingdao 266001, China. JIASHAODAN@yahoo.com.cn
Wang
Yan-gang
YG
Li
Jing
J
D000328:Adult; D000368:Aged; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D033461:Hyperuricemia / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014527:Uric Acid / Q000097:blood
D007328:Insulin; D014527:Uric Acid