title: Programming and engineering biological networks.
abstract: Synthetic biology aims to build new functions in living organisms. Recent work has addressed the creation of synthetic epigenetic switches in mammalian cells and synthetic intracellular communication. Fundamentally new, and potentially scaleable, modes of gene regulation have been created that enable expansion of the scope of synthetic circuits. Increasingly sophisticated models of gene regulation that include stochastic effects are beginning to predict the behaviour of small synthetic networks. Overall, these advances suggest that a combination of molecular engineering and systems engineering should allow the creation of living matter capable of performing many useful and novel functions.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. chin@mrc-lmb.cam.ac.uk
authors.forename: Jason W
authors.initials: JW
authors.lastname: Chin
mesh_terms: D001698:Biomedical Engineering; D002450:Cell Communication / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D012270:Ribosomes / Q000737:chemistry / Q000502:physiology*