title: beta-Glucosidase inhibitory activities of phenylpropanoid glycosides, vanicoside A and B from Polygonum sachalinense rhizome.
abstract: The phenylpropanoid glycosides, vanicoside A and B, isolated from rhizomes of giant knotweed (Polygonum sachalinense) showed beta-glucosidase inhibitory activity, with IC(50) values of 59.8 and 48.3 mug/ml (59.9 and 50.5 muM), respectively. In contrast, p-coumaric acid and ferulic acid, corresponding to phenylpropanoyl moieties of vanicosides, exhibited very little inhibition.
authors.affiliation: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan. kawai@fish.hokudai.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Kumagai
authors.forename: H
authors.initials: H
authors.lastname: Kurihara
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: R
authors.initials: R
authors.lastname: Sawano
authors.forename: N
authors.initials: N
authors.lastname: Inoue
mesh_terms: D002934:Cinnamates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D028502:Polygonum; D027343:Rhizome; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*
chemical_list: D002934:Cinnamates; D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; C087106:vanicoside B; C087105:vanicoside A; D001617:beta-Glucosidase