title: Molecular mechanism of the life and death of the osteoclast.
abstract: The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. TANAKAS-ORT@h.u-tokyo.ac.jp
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Fukuda
authors.forename: Toru
authors.initials: T
authors.lastname: Akiyama
authors.forename: Yuho
authors.initials: Y
authors.lastname: Kadono
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Wakeyama
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Kono
authors.forename: Shinya
authors.initials: S
authors.lastname: Hoshikawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohshima
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hikita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakamura
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D017209:Apoptosis; D016923:Cell Death; D002470:Cell Survival; D006706:Homeostasis; D006801:Humans; D010010:Osteoclasts / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction