Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins.
The formation of protein-decorated nanosized polymeric particles is described. Annexin-A5 protein binding to micellar aggregates having poly((1-ethoxycarbonyl)vinylphosphonic diacid) (PECVPD) and poly(n-butyl acrylate) (PBuA) as corona- and core-forming segments, respectively, was evidenced by Static and Dynamic Light Scattering (SDLS), cryo-Transmission Electron Microscopy (cryo-TEM), and Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments. These new objects find potential applications, for example, in micelle-mediated target drug delivery and controlled fabrication of biochips.
Schmidt
Vanessa
V
Laboratoire de Chimie des Polymères Organiques (LCPO), ENSCPB, Université Bordeaux 1, 16 Av. Pey Berland, 33607 Pessac Cedex, France.
Giacomelli
Cristiano
C
Lecolley
François
F
Lai-Kee-Him
Joséphine
J
Brisson
Alain R
AR
Borsali
Redouane
R
D017304:Annexin A5 / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*
D017304:Annexin A5; D008823:Micelles