[Effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane in anesthetized dogs and rats].
OBJECTIVE
To study the effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane.


METHODS
Cerebral blood stream flux, resistance of blood vessels, blood pressure and heart rate were used as observation indexes in hemodynamics experiment. Artery caliber and the number of capillaries with recovered blood stream were used as observation indexes in microcirculation experiment.


RESULTS
Naoan tablets at dose of 0.5 g x kg(-1) and 1.0 g x kg(-1) could enhance cerebral blood stream flux, decrease resistance of blood vessels, and reduce blood pressure. While no effects on heart rate. Naoan tablet at dose of 0.7 g x kg(-1) and 2.1 g x kg(-1) could increase the number of capillaries with recovered blood stream and enlarge the artery caliber of soft membrane in rats.


CONCLUSIONS
Naoan tablets can improve the indexes of hemodynamics and cerebral microcirculation of soft membrane.
Zhang
Da-fang
DF
Pharmacy College, Changchun University of Traditional Chinese Medicine.
Wang
Xiu-hua
XH
Li
Li-jing
LJ
Cai
Wen-jing
WJ
Zhang
Ya-jie
YJ
D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D029745:Codonopsis / Q000737:chemistry; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets; D014655:Vascular Resistance / Q000187:drug effects
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; C529018:naoan