title: Raised plasma adiponectin levels in type 1 diabetic pregnancies.
abstract: OBJECTIVE
  Adiponectin has antidiabetic properties. Our aim was to determine plasma adiponectin levels during pregnancy and postpartum (PP), in women with type 1 diabetic mellitus (T1DM) and nondiabetic (ND) women.
  
  
  METHODS
  Fasting plasma adiponectin and leptin levels were measured in 20 ND and 19 T1DM women, at 20 and 30 weeks' gestation, and 9 months' PP. Insulin measurements were made in ND women.
  
  
  RESULTS
  In both groups, after accounting for body mass index (BMI), leptin levels increased during pregnancy (P < 0.01) and were significantly higher than PP (P < 0.001). However, no significant differences in leptin levels were noted between both groups at any stage (P = 0.46). Conversely, adiponectin levels were higher in T1DM at all stages of the study (P < 0.001). A significant fall in adiponectin levels was seen between 20 and 30 weeks' gestation in both groups (ND: P < 0.001; T1DM: P < 0.05); however, this decrease was attenuated in the T1DM group. Adiponectin levels PP were significantly higher than at 30 weeks (ND: P < 0.001; T1DM: P < 0.001). Furthermore, in T1DM, adiponectin appeared to correlate negatively with leptin, but only reached significance PP (r = -0.46, P < 0.001). In the ND group, adiponectin correlated negatively with both leptin (PP: r = -0.56, P < 0.0001) and insulin (P < 0.005).
  
  
  CONCLUSIONS
  Higher adiponectin levels were noted in T1DM throughout gestation compared to ND pregnancies, with no difference in leptin levels. The significance of these findings needs to be determined.
authors.affiliation: Molecular Medicine Group, Biological Sciences, University of Warwick, and Metabolic Unit, University Hospitals Coventry and Warwickshire NHS Trust, UK. hrandeva@bio.warwick.ac.uk
authors.forename: Harpal S
authors.initials: HS
authors.lastname: Randeva
authors.forename: Manu
authors.initials: M
authors.lastname: Vatish
authors.forename: Bee K
authors.initials: BK
authors.lastname: Tan
authors.forename: Zubair
authors.initials: Z
authors.lastname: Qureshi
authors.forename: Padmabushan
authors.initials: P
authors.lastname: Boovalingam
authors.forename: Krzysztof C
authors.initials: KC
authors.lastname: Lewandowski
authors.forename: Paul
authors.initials: P
authors.lastname: O'Hare
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D015999:Multivariate Analysis; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000097:blood*
chemical_list: D052242:Adiponectin; D007328:Insulin; D020738:Leptin