[Studies on chemical constituents in root of Phlomis medicinalis I].
OBJECTIVE
To study the chemical constituents in root of Phlomis medicinalis.


METHODS
The compounds were isolated and repeatedly purified on macroporous resin, silica gel column chromatography, TLC and Prep-HPLC and the structures were elucidated by physico-chemical properties and NMR spectra.


RESULTS
Eight compounds were obtained and elucidated as 5-Hydroxy-7-methoxy-4, 6-dimethylphthalide (1), 4-hydroxymethyl-2-furaldehyde (2) and six iridoid glucosides: 6-O-acetyl-shanzhiside methyl ester (3), 8-O-acetyl-shanzhiside methyl ester (4), shanzhiside methyl ester (5), sesamoside (6), phloyoside II (7) and dehydropentstemoside (8).


CONCLUSIONS
All the compounds were isolated from the plant for the first time and 1 and 3 were obtained from the plants of Phlomis for the first time.
Yu
Zhen-xi
ZX
College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine.
Wang
Gang-li
GL
Bianba
Ciren
C
Lin
Rui-chao
RC
D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D031345:Phlomis / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
C529015:5-hydroxy-7-methoxy-4,6-dimethylphthalide; C529016:6-O-acetylshanzhiside methyl ester; D001572:Benzofurans; D005960:Glucosides; D010936:Plant Extracts; D011714:Pyrans; D013729:Terpenes; C407310:phloyoside II; C099471:sesamoside; C099473:8-O-acetyl shanzhiside methyl ester