title: [Clinical significance of the pharmacokinetic interactions between drugs and phytopreparations].
abstract: In modern clinics, the pharmacotherapy is frequently accompanied by the administration of phytopreparations (by which are implied any preparations based on or containing plant materials). There are many data indicative of the possible pharmacokinetic interactions between drugs and phytopreparations. Among the most important issues is the ability of components of phytopreparations to induce or inhibit the isoenzymes of cytochrome P-450 and/or glycoprotein P. For this reason, phytopreparations can either increase or decrease the efficacy of jointly admninistared drugs, as well as provoke the development of undesired side reactions.
authors.forename: D A
authors.initials: DA
authors.lastname: Sychev
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.forename: E V
authors.initials: EV
authors.lastname: Shikh
authors.forename: V M
authors.initials: VM
authors.lastname: Bulaev
authors.forename: G V
authors.initials: GV
authors.lastname: Ramenskaia
authors.forename: S V
authors.initials: SV
authors.lastname: Kolkhir
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D041743:Herb-Drug Interactions; D006801:Humans; D028321:Plant Preparations / Q000493:pharmacokinetics* / Q000627:therapeutic use*
chemical_list: D028321:Plant Preparations; D003577:Cytochrome P-450 Enzyme System