Poly(ADP-ribose): novel functions for an old molecule.
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.
Schreiber
Valérie
V
Département Intégrité du Génome de l'UMR 7175, Centre National de la Recherche Scientifique, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard S. Brant, BP 10413, F-67412 Illkirch Cedex, France. schreiber@esbs.u-strasbg.fr
Dantzer
Françoise
F
Ame
Jean-Christophe
JC
de Murcia
Gilbert
G
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D004249:DNA Damage; D004260:DNA Repair; D004167:Diphtheria Toxin / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008958:Models, Molecular; D005810:Multigene Family; D009243:NAD / Q000096:biosynthesis; D011064:Poly Adenosine Diphosphate Ribose / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D004167:Diphtheria Toxin; D020033:Protein Isoforms; D009243:NAD; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases