Seasonal effects of Selank on the behavior of hibernating animals.
We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no effect on locomotor activity of animals. The selective stimulatory effect of Selank on exploratory behavior of hibernating animals was season-dependent. The maximum effect was observed under conditions of seasonal depression-like state.
Semenova
T P
TP
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino. tat_semenova@icb.psn.ru
Kozlovskaya
M M
MM
Zuikov
A V
AV
Kozlovskii
I I
II
Andreeva
L A
LA
D000818:Animals; D001110:Arctic Regions; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D006605:Hibernation / Q000187:drug effects*; D008297:Male; D009043:Motor Activity; D009068:Movement; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry; D012589:Sciuridae; D012621:Seasons
D009842:Oligopeptides; D010455:Peptides; C100827:TP 7