title: The pros and cons of split-dose granulocyte colony-stimulating factor alone rather than a single high dose for hematopoietic progenitor cell mobilization in small children (< 15 kg) with solid tumors.
abstract: Hematopoietic progenitor cells were mobilized in 34 children with solid tumors weighing < or = 15 kg using granulocyte colony-stimulating factor alone at the doses of 10, 20 or 2 x 12 microg/kg/day. The mobilization with 2 x 12 microg/kg/day was more efficient than that with 10 mg/kg/day. Although the superiority of the split-dose compared to the single, high daily dose (20 microg/kg/day) was not statistically significant, our results suggest that the 2 x 12 microg/kg/day regimen is interesting.
authors.forename: Etienne
authors.initials: E
authors.lastname: Merlin
authors.forename: Christophe
authors.initials: C
authors.lastname: Piguet
authors.forename: Anne
authors.initials: A
authors.lastname: Auvrignon
authors.forename: Hervé
authors.initials: H
authors.lastname: Rubie
authors.forename: François
authors.initials: F
authors.lastname: Deméocq
authors.forename: Justyna
authors.initials: J
authors.lastname: Kanold
mesh_terms: D049628:Body Size; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000628:therapy*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor