title: Practical and convenient synthesis of N-heterocycles: stereoselective cyclization of N-alkenylamides with t-BuOI under neutral conditions.
abstract: [Structure: see text] tert-Butyl hypoiodite (t-BuOI) was found to be a powerful reagent for the cyclization of N-alkenylamides leading to a variety of N-heterocycles under extremely mild conditions. When N-alkenylsulfonamides were employed in the reaction, three- to six-membered saturated N-heterocycles were obtained in good to excellent yields with complete stereoselectivity. The method was applicable to the cyclization of alkenylbenzamide derivatives to afford N-, O- or N-, S-heterocycles.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan. minakata@chem.eng.osaka-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minakata
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Morino
authors.forename: Yoji
authors.initials: Y
authors.lastname: Oderaotoshi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Komatsu