title: Coplanar and non-coplanar congener-specificity of PCB bioaccumulation and immunotoxicity in sea stars.
abstract: The sea star Asterias rubens (L.), a representative species of the North Sea benthic environment, was exposed to a mixture of 10 selected PCB congeners (3 coplanar or c-PCBs, and 7 non-coplanar) via experimentally contaminated sediments. Both the degree of bioaccumulation and subsequent immunotoxic effects of these PCBs were determined. A strong congener-specificity for both bioaccumulation and immunotoxicity was found as well as a probable induction of a congener-specific detoxification mechanism resulting in the dramatic decrease in body levels of the three coplanar congeners tested (PCBs 77, 126 and 169). Moreover, a correlation was found between the bioaccumulation of c-PCBs and their immunotoxic effects. These findings suggest that coplanar congeners should be included in the list of congeners recommended to be analyzed for biological impact-oriented marine monitoring programmes.
authors.affiliation: Laboratoire de Biologie Marine CP160/15, Université Libre de Bruxelles, 50 Avenue FD Roosevelt, B-1050 Brussels, Belgium. bruno.danis@naturalsciences.be
authors.forename: Bruno
authors.initials: B
authors.lastname: Danis
authors.forename: Chantal
authors.initials: C
authors.lastname: Cattini
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Teyssié
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Villeneuve
authors.forename: Scott W
authors.initials: SW
authors.lastname: Fowler
authors.forename: Michel
authors.initials: M
authors.lastname: Warnau
mesh_terms: D000818:Animals; D047271:Asterias / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D004781:Environmental Exposure; D019015:Geologic Sediments / Q000032:analysis; D007700:Kinetics; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000032:analysis; D013223:Statistics as Topic; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D017382:Reactive Oxygen Species; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls