title: [Osteopontin as a potential biomarker of metastasis and recurrence for hepatocellular carcinoma].
abstract: OBJECTIVE
  Osteopontin (OPN), a secretory phosphorylated glycoprotein and integrin-binding protein, has been involved in tumorigenesis, progression, invasion, and metastasis. OPN is over-expressed in a variety of human tumors. This study was to evaluate the value of OPN detection in forecasting the postoperative metastasis and recurrence of hepatocellular carcinoma (HCC).
  
  
  METHODS
  Plasma OPN level of 56 patients with HCC was detected before operation by enzyme-linked immunosorbent assay (ELISA), and plasma samples of 23 healthy volunteers were also analyzed as control group. The correlation of plasma OPN level to metastasis and recurrence of HCC was analyzed.
  
  
  RESULTS
  Plasma OPN level was significantly higher in HCC group than in control group [(864.4+/-391.9) microg/L vs. (382.5+/-169.4) microg/L, P<0.001]. During the follow-up, 25 patients had tumor recurred. Plasma OPN level was significantly higher in the patients with early HCC recurrence than in those without recurrence [(961.0+/-411.6) microg/L vs. (744.6+/-323.9) microg/L, P=0.039]. Cox multivariate analysis showed that plasma OPN level, cirrhosis, and tumor size were independent predictors for HCC recurrence and metastasis.
  
  
  CONCLUSIONS
  Plasma OPN level may be a potential diagnostic marker for predicting metastasis and recurrence of HCC.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
authors.forename: Bo-Kang
authors.initials: BK
authors.lastname: Cui
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Yuan
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Min-Shan
authors.initials: MS
authors.lastname: Chen
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D053495:Osteopontin / Q000097:blood*; D016016:Proportional Hazards Models; D011897:Random Allocation
chemical_list: D014408:Biomarkers, Tumor; D053495:Osteopontin