title: Influence of previous radiotherapy on free tissue transfer in the head and neck region: evaluation of 455 cases.
abstract: OBJECTIVE
  The aim of this retrospective cohort study was to investigate the effect of prior radiotherapy (XRT) on the outcome of microvascular free tissue transfer in the head and neck region.
  
  
  METHODS
  Four hundred fifty-five patients, subdivided into three groups, were analyzed. Groups I (no previous XRT, n=110), II (previous radiochemotherapy with 50 Gy focus dosage in the primary treatment regime for oral cancer, n=322), and III (secondary reconstruction after XRT-induced complications, n=23) were compared regarding flap success rate, postoperative complications, postoperative mortality, duration of intensive care (DOIC), and hospitalization (DOH).
  
  
  RESULTS
  Flap success did not differ significantly across groups (I: 95.5%, II: 93.2%, III: 91.3%. Risk of postoperative complications was significantly lower for group I (12.7%) compared with groups II (23.9%) and III (39.1%). DOIC and DOH were significantly shorter for patients in group I than for those in groups II and III.
  
  
  CONCLUSIONS
  XRT before free tissue transfer does not significantly increase flap loss or postoperative mortality but does increase postoperative complications and length of hospitalization.
authors.affiliation: Hospital of Cranio-Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria. clemens.klug@meduniwien.ac.at
authors.forename: Clemens
authors.initials: C
authors.lastname: Klug
authors.forename: Dominik
authors.initials: D
authors.lastname: Berzaczy
authors.forename: Heidrun
authors.initials: H
authors.lastname: Reinbacher
authors.forename: Martin
authors.initials: M
authors.lastname: Voracek
authors.forename: Thomas
authors.initials: T
authors.lastname: Rath
authors.forename: Werner
authors.initials: W
authors.lastname: Millesi
authors.forename: Rolf
authors.initials: R
authors.lastname: Ewers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods*