title: A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin.
abstract: The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.
authors.affiliation: Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63/77, Wrocław, Poland. kawa@microb.uni.wroc.pl
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Drulis-Kawa
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gubernator
authors.forename: Agata
authors.initials: A
authors.lastname: Dorotkiewicz-Jach
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Doroszkiewicz
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Kozubek
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology*; D008081:Liposomes / Q000737:chemistry*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008081:Liposomes; D013845:Thienamycins; D000077731:Meropenem