Human neuroblastoma stem cells.
Human neuroblastoma is an embryonic cancer of the neural crest. Cellular heterogeneity is a characteristic feature of both tumors and derived cell lines. Recent studies have revealed that both cell lines and tumors contain cancer stem cells. In culture, these cells are self-renewing, multipotent, and highly malignant; in tumors their frequency correlates with a worse prognosis. Their identification and characterization should now permit a targeted approach to more effective treatment of this often fatal childhood cancer.
Ross
Robert A
RA
Laboratory of Neurobiology, Department of Biological Sciences, 441 East Fordham Road, Fordham University, Bronx, NY 10458, USA. rross@fordham.edu
Spengler
Barbara A
BA
D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009432:Neural Crest / Q000473:pathology; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology*