New phenolic glycosides from the stems and leaves of Casearia multinervosa.
Four phenolic glycosides (1-4), including two new ones (3 and 4), have been isolated from the stems of Casearia multinervosa and identified as arbutin (1), 4-O-E-caffeoylarbutin (2), 4-O-E-coumaroylarbutin (3) and 4-O-E-feruloylarbutin (4), respectively. In addition, the two known phenolic glycosides (1 and 2) were also isolated from the leaves. Structures were elucidated on the basis of spectroscopic evidence. Compounds 1-4 were tested for cytotoxicity against the P388 mouse lympholytic cell line by an ATP Lite-M assay method and showed mild to moderate activity.
Ashik
M
M
Centre for Phytochemistry and Pharmacology, Southern Cross University, P.O. Box 157, Lismore, NSW 2480, Australia.
Flowers
Mosaddik Andrew
MA
Karagianis
Gloria
G
Waterman
Peter G
PG
D000818:Animals; D001104:Arbutin / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D037821:Casearia / Q000737:chemistry*; D002460:Cell Line; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D010636:Phenols; D001104:Arbutin