Extended-release opioids for the management of chronic non-malignant pain.
Recent clinical trials have documented the use of extended-release (ER) opioids in the management of chronic non-malignant pain. This manuscript reviews the clinical pharmacology of investigational and current marketed ER opioids. Recent randomised clinical trials of ER opioids that document the efficacy and safety of opioid therapy for chronic pain are reviewed. Finally, the abuse liability of ER opioids is discussed. Current technologies aimed at defeating the abuse of ER opioids will also be presented.
Sloan
Paul
P
University of Kentucky Medical Center, Department of Anesthesiology, 800 Rose Street, Suite N212, Lexington, KY 40536, USA. paulsloan1956@yahoo.com
Babul
Najib
N
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D006801:Humans; D010146:Pain / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control
D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations