Hormone receptor status of operable breast cancers in Indonesia: correlation with other prognostic factors and survival.
OBJECTIVE
The aim of this study was to evaluate the hormone receptor status of operable breast cancers in Yogyakarta, Indonesia , and its correlation with other established prognostic factors and overall survival.


METHODS
Operable breast cancers in Yogyakarta were studied clinically, pathologically and immunohistochemically for tumor size, lymph node status, histological grade, mitotic index, ER, PR, c-erbB2, p53 and MIB-1 proliferation index. Correlations of ER and PR with those prognostic factors were determined, and patients were longitudinally followed for overall survival.


RESULTS
Breast cancer showed an aggressive phenotype with large tumor size, positive lymph nodes, high histologic grade, high mitotic index, positive c-erbB2, p53 and MIB- 1 proliferation index. Positive ER and PR did not improve the prognosis significantly, and adjuvant treatment with tamoxifen did not increase overall survival.
Aryandono
Teguh
T
Department of Surgery, Sardjito General Hospital,Yogyakarta 55284, Indonesia. gagoek@idola.net.id
Harijadi
Soeripto
D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007214:Indonesia; D019394:Ki-67 Antigen / Q000378:metabolism; D008940:Mitotic Index; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53