title: A 24-hour dental plaque prevention study with a stannous fluoride dentifrice containing hexametaphosphate.
abstract: Recently, a novel antibacterial fluoride dentifrice containing stannous fluoride and sodium hexametaphosphate (CrestPRO-HEALTH) was introduced. A digital plaque image analysis (DPIA) technique was used to quantify in situ plaque formation in a population carrying out a phased intervention protocol that included: (1) an initial treatment regimen including toothbrushing with standard sodium fluoride dentifrice in conventional bid brushing, (2) a second treatment regimen where a modified hygiene regimen was applied using standard sodium fluoride dentifrice including a period of 24 hours of non-brushing, and (3) a third treatment regimen where the 24-hour non-brushing regimen was continued using the antimicrobial stannous fluoride/sodium hexametaphosphate dentifrice. The quantitative evaluation of plaque formation was assessed in morning measurements following either standard evening hygiene (treatment period 1) or 24 hours since brushing (treatment periods 2 and 3). Post-brushing plaque measurements were also taken in each treatment regimen. Sixteen subjects completed all three treatment regimens with no side effects or oral complaints. Morning plaque coverage in treatment period 1 was 13.3%. Plaque coverage significantly increased in treatment period 2 when pre-bedtime brushing was discontinued, with 24-hour growth covering 18.4% of the dentition. Intervention of the antimicrobial stannous fluoride/hexametaphosphate dentifrice in treatment period 3 provided significant inhibition of plaque regrowth over 24 hours (15.2% coverage, a 17% reduction vs. sodium fluoride dentifrice control). These results support the strong retention and lasting antimicrobial efficacy of high stabilized stannous fluoride/sodium hexametaphosphate dentifrices.
authors.affiliation: Procter & Gamble Company Health Care Research Center, Cincinnati, Ohio, USA. white.dj@pg.com
authors.forename: Donald J
authors.initials: DJ
authors.lastname: White
authors.forename: Kathy M
authors.initials: KM
authors.lastname: Kozak
authors.forename: Roger
authors.initials: R
authors.lastname: Gibb
authors.forename: John
authors.initials: J
authors.lastname: Dunavent
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Klukowska
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sagel
mesh_terms: D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000627:therapeutic use*; D012824:Silicic Acid; D012822:Silicon Dioxide / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D014002:Tin Fluorides / Q000627:therapeutic use*; D014100:Toothpastes
chemical_list: C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D012822:Silicon Dioxide; D012969:Sodium Fluoride