title: Unusual case of acanthamoeba keratitis in a contact lens wearer.
abstract: OBJECTIVE
  To present an atypical case of acanthamoeba keratitis in a soft contact lens wearer.
  
  
  METHODS
  A case report of a 28-year-old female soft contact lens wearer with a 6-day history of redness and blurred vision in her right eye. Examination showed stromal keratitis that did not respond to therapy for herpes simplex virus. Four weeks later, the patient had increased stromal infiltration, an endothelial plaque, and a hypopyon. She did not complain of pain apart from mild discomfort. Corneal smears and anterior chamber tap were negative for bacteria, fungi, acanthamoeba, and herpes simplex virus, and the patient was prescribed fortified antibiotics. One week later, a large epithelial defect with a surrounding ring infiltrate was apparent. Corneal biopsy showed acanthamoeba.
  
  
  RESULTS
  The acanthamoeba keratitis resolved with successful treatment. One year later, the patient had a residual visual deficit secondary to stromal scarring and her best-corrected visual acuity was 20/29.
  
  
  CONCLUSIONS
  This case emphasizes the importance of considering acanthamoeba species in the differential diagnosis of keratitis, even without the classic symptom of severe pain. A high degree of suspicion with rapid and appropriate treatment may result in improved recovery of vision.
authors.affiliation: Department of Ophthalmology, University of Patras Medical School, Patras, Greece. cgeorg@med.upatras.gr
authors.forename: Constantine D
authors.initials: CD
authors.lastname: Georgakopoulos
authors.forename: Artemis M
authors.initials: AM
authors.lastname: Exarchou
authors.forename: Sotirios P
authors.initials: SP
authors.lastname: Gartaganis
mesh_terms: D000048:Acanthamoeba / Q000302:isolation & purification; D015823:Acanthamoeba Keratitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D001645:Biguanides / Q000627:therapeutic use; D001706:Biopsy; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003319:Corneal Stroma / Q000469:parasitology / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009355:Neomycin / Q000627:therapeutic use
chemical_list: D000977:Antiparasitic Agents; D001645:Biguanides; C031233:polihexanide; D009355:Neomycin