Combinatorial library synthesis of antioxidant compounds.
Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.
Mittoo
Stifun
S
School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. sm15@soton.ac.uk
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry*; D002109:Caffeic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007191:Indazoles / Q000737:chemistry; D015394:Molecular Structure; D019151:Peptide Library; D011409:Propylene Glycols / Q000737:chemistry; D011809:Quinones / Q000737:chemistry
D000975:Antioxidants; D002109:Caffeic Acids; D007191:Indazoles; D019151:Peptide Library; D011409:Propylene Glycols; D011809:Quinones