title: Meiosis study in a population sample from Afghanistan: allele frequencies and mutation rates of 16 STR loci.
abstract: The 16 short tandem repeat systems D3S1358, VWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820, ACTBP2, D2S1338, D16S539, D19S433, D21S11, D18S51 and D8S1179 were amplified in a population sample composed of 333 immigrants from Afghanistan. The 16 loci met Hardy-Weinberg expectations and possess a combined matching probability of 1 in 3.6 x 10(14) and a combined mean exclusion chance greater than 0.9996 in this Afghan population. Approximately 12,000 meiotic transfers were investigated and 19 mutations were observed in the repeat units of FGA (n=6), ACTBP2 (n=5), D3S1358 (n=2), D5S818 (n=2), D7S820 (n=2), VWA (n=1) and D8S1179 (n=1).
authors.affiliation: Institut für Rechtsmedizin, Universitätsklinikum Münster, Röntgenstrasse 23, 48149, Münster, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Hohoff
authors.forename: Marianne
authors.initials: M
authors.lastname: Schürenkamp
authors.forename: Torsten
authors.initials: T
authors.lastname: Börchers
authors.forename: Marjon
authors.initials: M
authors.lastname: Eppink
authors.forename: Bernd
authors.initials: B
authors.lastname: Brinkmann
mesh_terms: D000328:Adult; D000346:Afghanistan; D000483:Alleles; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D010334:Paternity