title: Nonlinear absorption in biological tissue for high intensity focused ultrasound.
abstract: In recent years the propagation of the high intensity focused ultrasound (HIFU) in biological tissue is an interesting area due to its potential applications in non-invasive treatment of disease. The base principle of these applications is the heat effect generated by ultrasound absorption. In order to control therapeutic efficiency, it is important to evaluate the heat generation in biological tissue irradiated by ultrasound. In his paper, based on the Khokhlov-Zabolotkaya-Kuznetsov (KZK) equation in frequency-domain, the numerical simulations of nonlinear absorption in biological tissues for high intensity focused ultrasound are performed. We find that ultrasound thermal transfer effect will be enhanced with the increasing of initial acoustic intensity due to the high harmonic generation. The concept of extra absorption factor is introduced to describe nonlinear absorption in biological tissue for HIFU. The theoretical results show that the heat deposition induced by the nonlinear theory can be nearly two times as large as that predicated by linear theory. Then, the influence of the diffraction effect on the position of the focus in HIFU is investigated. It is shown that the sound focus moves toward the transducer compared with the geometry focus because of the diffraction of the sound wave. The position of the maximum heat deposition is shifted to the geometry focus with the increase of initial acoustic intensity because the high harmonics are less diffraction. Finally, the temperature in the porcine fat tissue changing with the time is predicated by Pennes' equation and the experimental results verify the nonlinear theoretical prediction.
authors.affiliation: State Key Lab of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China. xzliu@nju.edu.cn <xzliu@nju.edu.cn>
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Liu
authors.forename: Junlun
authors.initials: J
authors.lastname: Li
authors.forename: Xiufen
authors.initials: X
authors.lastname: Gong
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000273:Adipose Tissue / Q000502:physiology* / Q000528:radiation effects*; D000818:Animals; D001831:Body Temperature / Q000502:physiology* / Q000528:radiation effects; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008954:Models, Biological; D017711:Nonlinear Dynamics; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D012062:Relative Biological Effectiveness; D012542:Scattering, Radiation; D013552:Swine; D014464:Ultrasonic Therapy / Q000379:methods*