Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents.
The self-assembly of supramolcular clusters of Gd(III) hydroxypyridinone complexes, templated by an Fe(III) terephthalamide center, is presented. The peripheral Gd(III) ions are each coordinated by two water molecules which exchange rapidly with the bulk solvent. These properties, along with the high rigidity of the supramolecules, efficiently increase the rotational correlation times of the cluster, resulting in high relaxivities at high magnetic fields and hence making these complexes good candidates for MRI contrast agents.
Pierre
Valérie C
VC
Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.
Botta
Mauro
M
Aime
Silvio
S
Raymond
Kenneth N
KN
D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure
D003287:Contrast Media; D005682:Gadolinium; D007501:Iron