title: Experimental advances for high-speed evaluation of electron densities.
abstract: Evaluating electron densities of entire classes of chemically or biologically related compounds is within reach thanks to advances in high-speed high-resolution synchrotron diffraction: a 12 h sequence of diffraction experiments has been conducted at the beamline X10SA of the Swiss Light Source (SLS). It resulted in four high-resolution X-ray data sets used for experimental electron density determinations of the two halogenated fullerenes C60F18 and C60Cl30, the Watson and Crick base pair adenine-thymine and the tripeptide L-Ala-Gly-L-Ala. Application is considered relevant for life sciences where the study of structure-guided biological recognition processes can now be completed by electronic information of entire series of molecules.
authors.forename: Peter
authors.initials: P
authors.lastname: Luger
authors.forename: Armin
authors.initials: A
authors.lastname: Wagner
authors.forename: Christian B
authors.initials: CB
authors.lastname: Hübschle
authors.forename: Sergey I
authors.initials: SI
authors.lastname: Troyanov
mesh_terms: D000225:Adenine / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004583:Electrons; D037741:Fullerenes / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
chemical_list: D037741:Fullerenes; D009842:Oligopeptides; D000225:Adenine; D013941:Thymine