Left-right asymmetry: actin-myosin through the looking glass.
Despite being bilaterally symmetric, most Metazoa exhibit clear, genetically determined left-right differences. In several animals, microtubule-based structures are thought to be the source of chiral information used to establish handedness. Now, two new studies in Drosophila identify a role for unconventional myosin motors in this process.
Baum
Buzz
B
Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK. buzz@ludwig.ucl.ac.uk
D000199:Actins / Q000378:metabolism*; D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000196:embryology / Q000378:metabolism / Q000648:ultrastructure*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000378:metabolism; D009154:Mutation; D024461:Myosin Type I / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D000199:Actins; D029721:Drosophila Proteins; C513226:Myo31DF protein, Drosophila; D024461:Myosin Type I