title: Transepithelial immunomodulation by cholera toxin and non-toxic derivatives.
abstract: Comparative analyses of murine dendritic cells (DC) isolated from the skin and from the intestinal mucosa after exposure to cholera toxin and its non-toxic B subunit disclose striking differences regarding the migratory and functional behaviour of these cells. The nature of the epithelial microenvironment, especially locally produced cytokines and chemokines, appears to influence the functional ability of skin and mucosal DCs to convey immunogenic as opposed to tolerogenic signals and hence to regulate immune responsiveness at skin and at mucosal sites.
authors.affiliation: INSERM U 721, Mucosal Immunity and Vaccinology, Faculté de Médecine Pasteur, 06107 Nice, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Anjuère
authors.forename: Carmelo
authors.initials: C
authors.lastname: Luci
authors.forename: Catherine
authors.initials: C
authors.lastname: Hervouet
authors.forename: Déborah
authors.initials: D
authors.lastname: Rousseau
authors.forename: Cecil
authors.initials: C
authors.lastname: Czerkinsky
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000279:Administration, Cutaneous; D002772:Cholera Toxin / Q000494:pharmacology*; D003713:Dendritic Cells / Q000276:immunology; D007108:Immune Tolerance; D018928:Immunity, Mucosal
chemical_list: D000276:Adjuvants, Immunologic; D002772:Cholera Toxin