Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.
The synthesis of new furo-salicylanilides and their heterocyclic derivatives is described. Twenty-three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.
Hassan
Ghaneya Sayed
GS
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Hegazy
Gehan Hegazy
GH
Safwat
Hany Mohamed
HM
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000138:chemical synthesis* / Q000633:toxicity; D015394:Molecular Structure; D008975:Molluscacides / Q000138:chemical synthesis* / Q000633:toxicity*; D009534:Niclosamide / Q000592:standards / Q000633:toxicity; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000633:toxicity; D012550:Schistosoma mansoni / Q000187:drug effects / Q000254:growth & development; D012995:Solubility; D013329:Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods
D005663:Furans; D008975:Molluscacides; D012458:Salicylanilides; D009534:Niclosamide