title: Clinical role of ABCF2 expression in breast cancer.
abstract: BACKGROUND
  The ATP binding cassette (ABC) family acts as efflux pumps and some members are related to chemoresistance in breast cancer. The clinical role of ABCF2 expression, a member of the ABC family, was analyzed.
  
  
  METHODS
  One hundred and ninety-one patients with breast cancer were enrolled. The median follow-up term was 76 months. ABCF2 expression was examined by immunohistochemistry.
  
  
  RESULTS
  Ninety percent of the breast cancer cases displayed immunoreactivity for ABCF2. The positive rate of ABCF2 expression was 63%. ABCF2 had a negative relationship to distant metastasis. ABCF2-positive tumors had longer disease-free survival (DFS) than -negative tumors in patients with lymph node metastasis (p = 0.001). In patients treated with endocrine therapy, ABCF2-positive tumors had a longer DFS when the tumors were estrogen receptor-negative or progesterone receptor-negative (p = 0.0019 and 0.005, respectively).
  
  
  CONCLUSIONS
  ABCF2 was initially thought to be related to drug resistance. ABCF2 may play a role in tumor suppression at metastatic sites and in the endocrine pathway for breast cancer.
authors.affiliation: Department of Surgery, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuda
authors.forename: Eishu
authors.initials: E
authors.lastname: Hai
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tsuji
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yamagata
authors.forename: Shinya
authors.initials: S
authors.lastname: Tokunaga
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamamori
authors.forename: Masao
authors.initials: M
authors.lastname: Ogawa
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishiguchi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D010865:Pilot Projects; D012189:Retrospective Studies
chemical_list: C507640:ABCF2 protein, human; D018528:ATP-Binding Cassette Transporters; D014408:Biomarkers, Tumor