title: Peripheral tissue energy metabolism during recovery from hypothermia after cardiopulmonary bypass: effect of amino-acid infusions.
abstract: We studied the effects of amino-acid administration on the leg exchange of energy substrates and amino-acids during recovery from hypothermia after open heart surgery. Glucose (G, n = 5), glucose and conventional amino-acids (CA, n = 5) or glucose and branched chain amino-acids (BC, n = 5) were infused during recovery from hypothermia after open heart surgery. The leg exchange of energy substrates and amino-acids were measured after arrival at the intensive care unit, after rewarming, and 2h and 4h after rewarming during increasing amino-acid intake. Despite a normal stress response to surgery, reflected by increased energy expenditure and increased concentrations of insulin and catabolic hormones, amino-acids had no effect on the leg exchange of branched chain amino-acids, glutamine, alanine and energy substrates. This suggests that the transport of amino-acids and energy substrates into the cell are impaired after hypothermic cardiopulmonary bypass and intracellular substrates are utilised for the increased demand for energy during rewarming.
authors.affiliation: Critical Care Research Program and Department of Intensive Care, Kuopio University Central Hospital, Box 21, SF - 70211 Kuopio, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Hersio
authors.forename: J
authors.initials: J
authors.lastname: Takala
authors.forename: A
authors.initials: A
authors.lastname: Kari
authors.forename: K
authors.initials: K
authors.lastname: Huttunen