Alternative splicing: new insights from global analyses.
Recent analyses of sequence and microarray data have suggested that alternative splicing plays a major role in the generation of proteomic and functional diversity in metazoan organisms. Efforts are now being directed at establishing the full repertoire of functionally relevant transcript variants generated by alternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell- and tissue-specific functions. Recent progress in these areas is summarized in this review.
Blencowe
Benjamin J
BJ
Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, Centre for Cellular and Biomolecular Research, Donnelly CCBR Building, University of Toronto, Toronto, ON M5S 3E1, Canada. b.blencowe@utoronto.ca
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D020869:Gene Expression Profiling / Q000379:methods / Q000639:trends; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology / Q000379:methods* / Q000639:trends*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods / Q000639:trends; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics*; D050436:Regulatory Elements, Transcriptional / Q000235:genetics; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics
D020033:Protein Isoforms; D012333:RNA, Messenger; D017411:Ribonucleoproteins, Small Nuclear