title: Continuous positive airway pressure ameliorated severe pulmonary hypertension associated with obstructive sleep apnea.
abstract: A 52-year-old obese woman was admitted to our institution for evaluation of dyspnea and pulmonary hypertension (PH). Polysomnography revealed severe obstructive sleep apnea (OSA) with an apnea hypopnea index of 99.8. Treatment with nocturnal continuous positive airway pressure (CPAP) resulted in correction of daytime hypoxemia, hypercapnia, and near-normalization of pulmonary artery pressure. To our knowledge, this is the most severe case of OSA-associated PH (approximately70 mmHg) reported to date, and it was successfully treated with nocturnal CPAP. This case demonstrates that OSA should be considered and polysomnography performed in all patients with PH, irrespective of severity, and that nocturnal CPAP has therapeutic effects on both OSA and daytime PH.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. aiko-oky@umin.ac.jp
authors.forename: Aiko
authors.initials: A
authors.lastname: Ogawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Emori
authors.forename: Wakako
authors.initials: W
authors.lastname: Sumita
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Watanabe
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujio
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Miyaji
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D045422:Continuous Positive Airway Pressure / Q000379:methods*; D004417:Dyspnea / Q000150:complications; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000628:therapy; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000628:therapy*; D000860:Hypoxia / Q000628:therapy; D008875:Middle Aged; D017286:Polysomnography; D011669:Pulmonary Wedge Pressure; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications*