title: Fragrance allergy: assessing the risk from washed fabrics.
abstract: The prevalence of contact allergy to fragrance ingredients increased during the last part of the 20th century with the consequence that a substantial number of individuals are at risk of experiencing allergic contact dermatitis (ACD) if they have a sufficient degree of skin exposure to the chemical to which they have become sensitized. Such exposure does not necessarily have to arise from the type of source that originally induced the sensitization. A number of sources of exposure are clearly associated with risk of elicitation of ACD, but the role of fragrance deposited on fabrics, for example as a result of laundry processes, also can be questioned. In this article, firstly, the risk of the induction of fragrance-related ACD from exposure to fragrance via fabric is considered. Using a quantitative risk-assessment approach, the risk appears to be extremely low. The possibility that fragrance residues on laundered fabrics might elicit reactions in those already sensitized by a different route is also discussed. Clinically, clothing pattern dermatitis associated with fragrance allergy is almost never observed, although this could be investigated clinically by exposing sensitized individuals to the relevant fragrance allergen.
authors.affiliation: Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedfordshire MK44 1LQ, UK. namali.corea@unilever.com
authors.forename: Namali V
authors.initials: NV
authors.lastname: Corea
authors.forename: David A
authors.initials: DA
authors.lastname: Basketter
authors.forename: Catherine
authors.initials: C
authors.lastname: Clapp
authors.forename: Arian
authors.initials: A
authors.lastname: Van Asten
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Marty
authors.forename: Annick
authors.initials: A
authors.lastname: Pons-Guiraud
authors.forename: Catherine
authors.initials: C
authors.lastname: Laverdet
mesh_terms: D000485:Allergens; D000818:Animals; D003257:Consumer Product Safety; D003877:Dermatitis, Contact / Q000209:etiology* / Q000517:prevention & control*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007846:Laundering / Q000379:methods*; D008432:Mathematical Computing; D051379:Mice; D023421:Models, Animal; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects* / Q000737:chemistry; D018570:Risk Assessment; D013784:Textiles / Q000032:analysis
chemical_list: D000485:Allergens; D010476:Perfume