Screening oocytes by polar body biopsy.
Preimplantation genetic aneuploidy screening performed by polar body biopsy has become a frequently used method, especially as in several countries only preconceptional genetic diagnosis is allowed. To penetrate the zona pellucida, mechanical, chemical and laser-assisted techniques have been introduced. In this paper, the advantages, disadvantages, efficacy and safety of these techniques are elucidated.
Dawson
A
A
Department of Gynaecology and Obstetrics, IVF Unit, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, Germany.
Griesinger
G
G
Diedrich
K
K
D000782:Aneuploidy; D001706:Biopsy / Q000379:methods; D004210:Dissection / Q000379:methods; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D007834:Lasers; D009865:Oocytes / Q000648:ultrastructure*; D019836:Preimplantation Diagnosis / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D015044:Zona Pellucida / Q000648:ultrastructure
D007552:Isotonic Solutions; C037692:Tyrode's solution