Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery.
The use of the nasal route for drug delivery has attracted much interest in recent years in the pharmaceutical field. Local and principally systemic drug delivery can be achieved by this route of administration. But the nasal route of delivery is not applicable to all drugs. Polar drugs and some macromolecules are not absorbed in sufficient concentration due to poor membrane permeability, rapid clearance and enzymatic degradation into the nasal cavity. Thus, alternative means that help overcome these nasal barriers are currently in development. Absorption enhancers such as phospholipids and surfactants are constantly used, but care must be taken in relation to their concentration. Drug delivery systems including liposomes, cyclodextrins, micro- and nanoparticles are being investigated to increase the bioavailability of drugs delivered intranasally. This review article discusses recent progress and specific development issues relating to colloidal drug delivery systems in nasal drug delivery.
Mainardes
Rubiana Mara
RM
Pós-graduação em Ciências Farmacêuticas, UNESP-Araraquara, Brasil. mainardes@fcfar.unesp.br
Urban
Maria Cristina Cocenza
MC
Cinto
Priscila Oliveira
PO
Chaud
Marco Vinícius
MV
Evangelista
Raul Cesar
RC
Gremião
Maria Palmira Daflon
MP
D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D014612:Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
D003102:Colloids; D004337:Drug Carriers; D008081:Liposomes; D014612:Vaccines