title: Ambroxol for the prevention of acute upper respiratory disease.
abstract: Although acute upper respiratory diseases (AURDs) such as common cold and influenza are common, few interventions have been proven to be effective in their prevention and treatment. The aim of this study was to assess the efficacy of ambroxol for preventing AURD. Fifty-four patients were randomly divided into 3 groups: a rebamipide (non-mucoactive drug) group (300 mg/day), carbocisteine group (1500 mg/day) and ambroxol group (45 mg/day). The study was divided into 2 terms, the first half-year (summer season) and the second half-year (winter season). In the preceding winter, only 19.5% of the patients had been vaccinated against influenza viruses (flu). The primary goal of this study was to evaluate the effectiveness of mucoactive drugs in decreasing the frequency of AURD. Treatment with ambroxol, but not carbocisteine, significantly reduced the median number of AURD episodes (P=0.0049 vs. rebamipide). Thirty-three patients without vaccination against flu were assessed especially during the second half-year. Treatment with ambroxol also significantly reduced the median number of AURD episodes in this assessment (P=0.0028 vs. rebamipide in the second half-year). In conclusion, ambroxol may be useful for preventing AURD.
authors.affiliation: Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa 920-8641, Japan. k-nobata@yg7.so-net.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Nobata
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: Y
authors.initials: Y
authors.lastname: Ishiura
authors.forename: S
authors.initials: S
authors.lastname: Myou
authors.forename: S
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000409:Alanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000551:Ambroxol / Q000627:therapeutic use*; D002233:Carbocysteine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D015363:Quinolones / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000517:prevention & control*
chemical_list: D015363:Quinolones; D000551:Ambroxol; D002233:Carbocysteine; C052785:rebamipide; D000409:Alanine