Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunction.
The cytochrome p450 2C (CYP2C) monooxygenase family is a key player in the generation of epoxyeicosatrienoic acids. It has recently become apparent that CYP plays an important role in cardiovascular physiology and contributes to the pathogenesis of various cardiovascular diseases. In particular, several studies have demonstrated a role for these enzymes in cardiac ischemia and reperfusion injury. The current review summarizes the role of the CYP epoxygenase, CYP2C9, in ischemic heart disease and vascular homeostasis.
Chehal
Manreet K
MK
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, University of British Columbia, Vancouver, Canada.
Granville
David J
DJ
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism*; D001685:Biological Factors / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000201:enzymology*; D065729:Cytochrome P-450 CYP2C9; D015777:Eicosanoids / Q000378:metabolism; D004730:Endothelium, Vascular / Q000201:enzymology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000201:enzymology*
D001685:Biological Factors; D015777:Eicosanoids; D017382:Reactive Oxygen Species; C067410:endothelium-dependent hyperpolarization factor; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases