title: Chordal cutting does not adversely affect left ventricle contractile function.
abstract: BACKGROUND
  Severing a limited number of second-order chordae to the anterior leaflet can improve ischemic mitral regurgitation (MR). Some concerns have been raised regarding possible influence on regional and global left ventricle (LV) function. We evaluated changes in cardiac function in 5 normal sheep with cutting of pre-instrumented chords in the beating heart to maintain constant load.
  
  
  RESULTS
  Under cardiopulmonary bypass, wires were placed around the 2 central basal chordae and brought outside the heart, which was restarted. Hemodynamic and imaging data were collected before and after chordal cutting by radiofrequency ablation using those wires. Segmental contractility was assessed invasively using sonomicrometers and noninvasively using Doppler tissue velocity and strain rate (with strain rate viewed as less load-dependent than ejection fraction) at 6 sites: base, mid-ventricle, and apex along the anteroseptal and posterolateral walls. We found no changes from before to after chordal cutting in LV end-diastolic volume (47.2+/-3.3 after cutting versus 48.4+/-4.6 mL before cutting, P=0.66), end-systolic volume (21.5+/-1.2 versus 22.3+/-2.8 mL, P=0.68), ejection fraction (54.2+/-1.8 versus 54.2+/-2.7%, P=0.96), systolic ventricular elastance (7.28+/-1.68 versus 7.66+/-2.11 mm Hg/mL, P=0.64), preload-recruitable stroke work (46.6+/-7.7 versus 50.2+/-10.7 mm Hg, P=0.76), and LVdP/dt (1480+/-238 versus 1392+/-250 mm Hg/s, P=0.45). Doppler tissue velocities and longitudinal strain rates surrounding the papillary muscles were unchanged, as were sonomicrometer longitudinal and mediolateral absolute strains. No wall motion abnormalities were visible around the papillary muscles, and no MR developed.
  
  
  CONCLUSIONS
  We find no evidence for acutely decreased global or segmental LV contractility with chordal cutting. This absence of adverse effects is consistent with long-term clinical experience with cutting these chords in valve repair.
authors.affiliation: Université René Descartes Paris, Faculté de Médecine, INSERM U633, Assistance Publique-Hôpitaux de Paris, Department of Cardiology, Hôpital Européen Georges Pompidou, Paris, France. emmanuel.messas@free.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Messas
authors.forename: Chaim
authors.initials: C
authors.lastname: Yosefy
authors.forename: Miguel
authors.initials: M
authors.lastname: Chaput
authors.forename: J Luis
authors.initials: JL
authors.lastname: Guerrero
authors.forename: Suzanne
authors.initials: S
authors.lastname: Sullivan
authors.forename: Philippe
authors.initials: P
authors.lastname: Menasché
authors.forename: Alain
authors.initials: A
authors.lastname: Carpentier
authors.forename: Michel
authors.initials: M
authors.lastname: Desnos
authors.forename: Albert A
authors.initials: AA
authors.lastname: Hagege
authors.forename: Gus J
authors.initials: GJ
authors.lastname: Vlahakes
authors.forename: Robert A
authors.initials: RA
authors.lastname: Levine
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002302:Cardiac Output; D002815:Chordae Tendineae / Q000502:physiology / Q000601:surgery*; D019560:Echocardiography, Three-Dimensional; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery* / Q000648:ultrastructure; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications; D012756:Sheep; D013314:Stress, Mechanical; D013318:Stroke Volume; D016276:Ventricular Function; D016277:Ventricular Function, Left