Conformational changes of DNA by photoirradiation of DNA-bis(Zn(II)-cyclen)-azobenzene complex.
Bis(Zn(II)-cyclen)-azobenzene derivative, which has two Zn(II)-macrocyclic tetraamine complexes connected through azobenzene spacer, has been synthesized as a cross-linking agent fordoublestranded DNA in aqueous solution. The Zn(II)-cyclen derivative selectively binds to A-T base pairs producing complexes between the Zn(II)-cyclen moiety and the imide-deprotonated thymine with breaking A-T base pairs. The azobenzene spacer undergoes cis/trans photoisomerization in the complex between the Zn(II)-cyclen derivative and the DNA duplex. The conformation of the DNA remarkably changed by photoisomerization of the azobenzene linker, when the Zn(II)-cyclen derivative binds to the DNA duplex with an interstrand cross-linking manner
Maie
Kenji
K
Department of Materials Science and Chemistry, University of Hyogo, Hyogo, Japan.
Nakamura
Mitsunobu
M
Yamana
Kazushige
K
D001391:Azo Compounds / Q000737:chemistry*; D000080027:Cyclams; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000528:radiation effects*; D017967:Zinc Compounds / Q000737:chemistry*
D001391:Azo Compounds; D000080027:Cyclams; D006571:Heterocyclic Compounds; D017967:Zinc Compounds; D004247:DNA; C038072:cyclen; C009850:azobenzene