title: Isolation and structures of new cyclomyltaylane and ent-chamigrane-type sesquiterpenoids from the liverwort Reboulia hemishaerica and their biotransformation by the fungus Aspergillus niger.
abstract: Reboulia hemisphaerica, the thalloid liverwort, contained four new cyclomyltaylane- and two new ent-beta-chamigrane-type sesquiterpenoids of which the absolute stereostructures were established by a combination of two-dimensional NMR spectroscopy, X-ray crystallographic analysis, and the modified Mosher's method. Cyclomyltaylan-5alpha-ol and ent-beta-chamigren-1alpha-ol were biotransformed by the fungus Aspergillus niger to afford new oxygenated matabolites. Their structures were also elucidated in the same manner as described above.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University; Tokushima Bunri University; Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Furusawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Noma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawaa
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D018360:Crystallography, X-Ray; D035926:Hepatophyta / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; C513801:cyclomyltaylan-5alpha-ol; C513802:ent-beta-chamigren-1alpha-ol