Synthesis of cyclic ADP-carbocylcic-xylose and its 3"-O-methyl analogue as stable and potent Ca2+ -mobilizing agents.
We previously showed that 3"-deoxy-cyclic ADP-carbocyclic-ribose (3"-deoxy-cADPcR, 3) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+ -mobilizing second messenger. From these results, we newly designed another 3"-modified analogues of cADPcR and identified the N1-"xylo"-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far.
Kudoh
Takashi
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.
Matsuda
Akira
A
Shuto
Satoshi
S
Murayama
Takashi
T
Ogawa
Yasuo
Y
D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010063:Ovum / Q000187:drug effects / Q000378:metabolism; D012617:Sea Urchins; D014994:Xylose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
C514989:3''-deoxy-cyclic ADP-carbocyclic-ribose; C439996:cyclic ADP-carbocyclic-ribose; C514988:cyclic ADP-carbocyclic-xylose; D036563:Cyclic ADP-Ribose; D014994:Xylose; D002118:Calcium