Chronic lymphoproliferative disorder with regulatory T-cell phenotype.
We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.
Kikuchi
Tomoko
T
Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Katayama
Yoshio
Y
Kubonishi
Shiro
S
Watanabe
Toshiyuki
T
Watanabe
Yukari
Y
Matsuoka
Ken-ichi
K
Maeda
Yoshinobu
Y
Namba
Noriko
N
Masunari
Taro
T
Nasu
Ryusuke
R
Ikeda
Kazuma
K
Tanimoto
Mitsune
M
D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015415:Biomarkers / Q000097:blood; D002454:Cell Differentiation; D002908:Chronic Disease; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000097:blood*; D046529:Microscopy, Electron, Transmission; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000378:metabolism / Q000648:ultrastructure; D015854:Up-Regulation
D015703:Antigens, CD; D015415:Biomarkers; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors