title: [Biological activity of the components of F1-antigen of Yersinia pestis].
abstract: Components of the capsule antigen (Baker), described early as F17, F18, F43, Flp, which positively reacts with commercial poly- and monoclonal antifractions plague diagnosticums were studied. Differences and their impacts on vaccine bacteria survival within peritoneal macrophages, guinea pigs and protection of white mice after immunization and fast protection against plague were shown. Hemolytic, cytolytic and hemo- and cytoagglutinations activities of lipoprotein (Flp) and capacity of glycoproteins F17 and F43 for induction of hemo- and cytoagglutinations were detected. Similarity of properties of enumerated components and lectins and their role in infection development and immunogenesis are discussed.
authors.forename: L V
authors.initials: LV
authors.lastname: Kosse
authors.forename: S A
authors.initials: SA
authors.lastname: Lebedeva
authors.forename: A S
authors.initials: AS
authors.lastname: Cherniavskaia
authors.forename: V N
authors.initials: VN
authors.lastname: Nekliaev
authors.forename: O V
authors.initials: OV
authors.lastname: Markina
authors.forename: I V
authors.initials: IV
authors.lastname: Morozova
authors.forename: N S
authors.initials: NS
authors.lastname: Eremenko
authors.forename: O I
authors.initials: OI
authors.lastname: Sal'nikova
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D016667:Bacterial Capsules / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D036781:Fimbriae Proteins / Q000276:immunology; D006168:Guinea Pigs; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D007274:Injections, Intraperitoneal; D008213:Lymphocyte Activation; D017737:Macrophages, Peritoneal / Q000276:immunology; D051379:Mice; D010930:Plague / Q000517:prevention & control; D010931:Plague Vaccine / Q000008:administration & dosage; D011817:Rabbits; D011933:Reagent Kits, Diagnostic; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D010931:Plague Vaccine; D011933:Reagent Kits, Diagnostic; C086725:caf1 protein, Yersinia pestis; D036781:Fimbriae Proteins