Further insights into the role of angiotensin II in kidney development.
Over the past decade, compelling studies have highlighted the fundamental role of the renin-angiotensin system (RAS) in renal development and long-term control of renal function and arterial pressure. The present review provides an update of the understanding of how the RAS controls nephrogenesis and nephrovascular development. In addition, the investigations linking the perinatal development of RAS inhibition-induced renal dysmorphology and establishment of adult blood pressure are discussed.
Lasaitiene
Daina
D
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden. daina.lasaitiene@wlab.gu.se
Chen
Yun
Y
Adams
Michael A
MA
Friberg
Peter
P
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D007668:Kidney / Q000196:embryology* / Q000648:ultrastructure; D008954:Models, Biological; D038081:Organogenesis; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology
D011945:Receptors, Angiotensin; D000804:Angiotensin II