The effect of intralipid on human lymphocyte and monocyte function.
Peripheral blood lymphocyte function (PHA) was unaffected by Intralipid in patients receiving lipid as part of a parenteral nutrition regime, and in volunteers receiving a small intravenous bolus. However monocyte function (chemotaxis) was significantly impaired by Intralipid in both groups. Three measures of monocyte function confirmed depression following in vitro exposure to Intralipid. Electronmicrographs of circulating monocytes and autoradiographs of cells exposed to 14C-Intralipid in vitro suggested that this detrimental effect on monocytes may follow phagocytosis of lipid particles. These findings suggest that caution should be exercised with the use of Intralipid in patients at particular risk of sepsis.
Fraser
I
I
Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester UK.
Neoptolemos
J
J
Woods
P
P
Bowry
V
V
Bell
P R
PR