Chemiluminescence sensor for the determination of perphenazine based on a molecular imprinted polymer.
A luminol-potassium ferricyanide-perphenazine CL reaction with high sensitivity for the determination of perphenazine was found. A perphenazine molecular imprinted polymer (MIP) was synthesized. Using the perphenazine MIP as a recognition material, a novel molecular imprinting-chemiluminescence (MI-CL) sensor for the determination of perphenazine was made based on the luminol-potassium ferricyanide-perphenazine CL reaction. The sensor displayed good selectivity and high sensitivity. The linear-response range of the sensor was 5.0 x 10(-8) - 1.0 x 10(-5) g/ml with a linear correlation coefficient of 0.9961. The detection limit was 2 x 10(-8) g/ml perphenazine and the relative standard deviation for 1.0 x 10(-6) g/ml perphenazine solution was 3.7% (n = 11). The sensor was applied to the determination of perphenazine in urine samples with satisfactory results.
Niu
Weifen
W
School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, P.R. China.
Nie
Fei
F
Lu
Jiuru
J
D005476:Fluphenazine / Q000032:analysis; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods*; D015394:Molecular Structure; D010546:Perphenazine / Q000032:analysis* / Q000652:urine; D011108:Polymers / Q000032:analysis* / Q000138:chemical synthesis; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors
D011108:Polymers; D010546:Perphenazine; D005476:Fluphenazine