Antimicrobial effect of silver-doped phosphate-based glasses.
In this study a range of phosphate-based glasses (PBG) doped with silver have been investigated for their antimicrobial activities. In disk diffusion assays, these compositions demonstrated microbistatic effects against a range of organisms including Staphylococcus aureus, Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and Candida albicans. The data obtained from the above studies allowed for an additional range of PBG containing lower amounts of silver to be studied for their effects on the growth and viability of S. aureus, E. coli, and C. albicans. PBG containing 3 and 5 mol % Ag were bactericidal for S. aureus and E. coli and significantly decreased the growth rate of C. albicans. A decrease in the dissolution rates of the glasses was seen with increasing Ag content over the range of concentrations investigated. Overall, 3 mol % Ag incorporated into the PBG investigated was sufficient to mount a potent antibacterial effect against the test organisms, and these compositions also gave excellent long-term release of Ag ions into the medium.
Ahmed
I
I
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD, United Kingdom.
Ready
D
D
Wilson
M
M
Knowles
J C
JC
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004058:Diffusion; D004926:Escherichia coli / Q000187:drug effects; D005898:Glass; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010710:Phosphates; D012834:Silver