Complex chemical kinetics in single enzyme molecules: Kramers's model with fractional Gaussian noise.
A model of barrier crossing dynamics governed by fractional Gaussian noise and the generalized Langevin equation is used to study the reaction kinetics of single enzymes subject to conformational fluctuations. The direct application of Kramers's flux-over-population method to this model yields analytic expressions for the time-dependent transmission coefficient and the distribution of waiting times for barrier crossing. These expressions are found to reproduce the observed trends in recent simulations and experiments.
Chaudhury
Srabanti
S
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Cherayil
Binny J
BJ
D001703:Biophysics / Q000379:methods*; D002627:Chemistry, Physical / Q000379:methods*; D003198:Computer Simulation; D004798:Enzymes / Q000737:chemistry*; D007700:Kinetics; D015233:Models, Statistical; D008962:Models, Theoretical; D016011:Normal Distribution; D013997:Time Factors
D004798:Enzymes