Invadopodia: specialized cell structures for cancer invasion.
The spread of cancer cells to distant sites in the body is the major cause of cancer patient death. Growing evidence connects specialized subcellular structures, invadopodia, to cancer invasion and metastasis. Invadopodia, or invasive foot processes, are actin-rich protrusions that localize matrix-degrading activity to cell-substratum contact points and represent sites where cell signaling, proteolytic, adhesive, cytoskeletal, and membrane trafficking pathways physically converge. Understanding how invadopodia form and function should aid in the identification of novel targets for anti-invasive therapy.
Weaver
Alissa M
AM
Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Alissa.Weaver@vanderbilt.edu
D000199:Actins / Q000378:metabolism; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*; D015398:Signal Transduction
D000199:Actins; D026901:Membrane Transport Proteins