title: Soft tissue osteochondroma: case report and immunohistochemistry for parathyroid hormone-related protein.
abstract: Surface lesions of bone usually present little diagnostic dilemma because the majority are conventional osteochondromas. Other surface bone lesions include periosteal chondroma, periosteal chondrosarcoma, and parosteal osteosarcoma. Mineralized soft tissue lesions such as myositis ossificans, synovial chondroma, and synovial sarcoma may present in a similar fashion when they occur in a juxtaarticular position. The soft tissue osteochondroma or paraarticular osteochondroma may simulate some of these more aggressive tumors, and its recognition is important to avoid overtreatment. A case of an 11-year-old male with a soft tissue osteochondroma is reported to illustrate the characteristic radiographic and histological features of this rare entity. No prior reports have examined soft tissue osteochondroma for expression of parathyroid hormone related protein, an established cartilage tumor proliferative mitogen.
authors.affiliation: Department of Orthopedic Surgery, Upstate Medical University, State University of New York at Syracuse, Syracuse, NY 13210, USA.
authors.forename: J Robyn
authors.initials: JR
authors.lastname: Ratcliff
authors.forename: Asghar
authors.initials: A
authors.lastname: Naqvi
authors.forename: Gustavo
authors.initials: G
authors.lastname: de la Roza
authors.forename: Judith A
authors.initials: JA
authors.lastname: Strauss
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Damron
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D015831:Osteochondroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D044162:Parathyroid Hormone-Related Protein / Q000032:analysis*; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D044162:Parathyroid Hormone-Related Protein