title: Microvascular density and endothelial area correlate with Ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneous model.
abstract: Experimental and clinical data indicate that tumor progression and malignancy are associated with increased angiogenesis and higher Ki-67 proliferation rate. Furthermore, increased angiogenesis and higher Ki-67 proliferation rate are associated with a poor prognosis, in both solid and hematological malignancies. However, no data have been published concerning the relationship between angiogenesis and Ki-67 proliferation rate in canine non-Hodgkin's lymphoma (NHL), a neoplasm that shares several biological and clinical characteristics with human NHL. This study has evaluated the relationship between angiogenesis and Ki-67 proliferation rate in a series of 58 canine NHL. Results showed that microvascular density (MVD), endothelial area (EA) and Ki-67 (MIB-1) are significantly correlated and that all the above indexes paralleled with the malignancy degree of NHL. These data suggest a biological link between angiogenesis and Ki-67 proliferation rate in canine NHL, which represents an interesting model to study the role of angiogenesis and proliferative activity as inter-species pathways of tumoral malignancy and biological aggressiveness.
authors.affiliation: Department of Animal Health and Well-Being, University of Bari Veterinary Medical School, Bari, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Patruno
authors.forename: Nicola
authors.initials: N
authors.lastname: Zizzo
authors.forename: Alfredo Franceso
authors.initials: AF
authors.lastname: Zito
authors.forename: Vittorio
authors.initials: V
authors.lastname: Catalano
authors.forename: Paolo
authors.initials: P
authors.lastname: Valerio
authors.forename: Valentina
authors.initials: V
authors.lastname: Pellecchia
authors.forename: Eustachio
authors.initials: E
authors.lastname: D'Errico
authors.forename: Francesco
authors.initials: F
authors.lastname: Mazzone
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
authors.forename: Girolamo
authors.initials: G
authors.lastname: Ranieri
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D049109:Cell Proliferation; D004285:Dogs; D004730:Endothelium, Vascular / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000378:metabolism* / Q000662:veterinary; D008833:Microcirculation; D009389:Neovascularization, Pathologic
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen