Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence.
Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice.
Filimonov
P N
PN
Novosibirsk State Medical Academy.
Sukhenko
T G
TG
Papantonopulo
A N
AN
Gavrilova
N I
NI
Shkurupii
V A
VA
D000367:Age Factors; D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000378:metabolism; D005355:Fibrosis / Q000473:pathology*; D003932:Heroin / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders; D013997:Time Factors
D008070:Lipopolysaccharides; D003208:Concanavalin A; D003932:Heroin