Baroreflex gain in normotensive and GH hypertensive rats before and after early gonadectomy.
The authors have assessed arterial baroreflex gain in urethane-anesthetized normotensive and New Zealand genetically hypertensive (GH) rats and investigated the effect of gonadectomy in adult animals at 3 weeks of age postnatally. No gender differences in resting blood pressures existed for either normotensive or GH strains. In normotensive animals, bradycardic gain was greater than tachycardic gain and was lower in females than in males. Tachycardic gain was similar in GH and normotensive rats of either sex, but bradycardic gain was lower in GH. Gonadectomy had no effect on baroreflex gain in male or female animals of either strain.
Tansey
Etain
E
Cardiovascular Health Unit, Department of Physiology, Trinity College Dublin, Dublin 2, Ireland.
Bell
Christopher
C
D000818:Animals; D030801:Animals, Genetically Modified; D017704:Baroreflex / Q000187:drug effects / Q000235:genetics; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics; D001919:Bradycardia / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage; D009919:Orchiectomy; D010052:Ovariectomy; D010656:Phenylephrine / Q000008:administration & dosage; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics; D011921:Rats, Inbred WKY / Q000235:genetics; D012044:Regression Analysis; D012737:Sex Factors; D013610:Tachycardia / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine