Inhibitory activity of plant stilbene oligomers against DNA topoisomerase II.
The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in alpha-viniferin 13-O-beta-glucopryranoside (2) and hemsleyanol C (13).
Yamada
Masashi
M
Meiji Dairies Corporation, Tokyo, Japan.
Hayashi
Ken-ichiro
K
Ikeda
Shogo
S
Tsutsui
Ken
K
Tsutsui
Kimiko
K
Ito
Tetsuro
T
Iinuma
Munekazu
M
Nozaki
Hiroshi
H
D000818:Animals; D016831:Crithidia fasciculata / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D010936:Plant Extracts / Q000494:pharmacology; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000037:antagonists & inhibitors*; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D015800:Protozoan Proteins; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors; C090528:DNA modification methylase HindIII; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)