title: Recent developments in the clinical pharmacology of classical cytotoxic chemotherapy.
abstract: Advances in analytical methods, imaging techniques and an increased understanding of the influence of pharmacogenetic factors have added to our knowledge of the pharmacology of many chemotherapeutic agents. Extending the use of these approaches to pharmacodynamic end-points, together with the application of population-based modelling techniques, offers the potential to develop truly individualized therapy in the future.
authors.affiliation: Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, UK. alan.boddy@newcastle.ac.uk
authors.forename: Alan V
authors.initials: AV
authors.lastname: Boddy
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D010597:Pharmacogenetics; D010601:Pharmacology, Clinical / Q000639:trends*
chemical_list: D000970:Antineoplastic Agents