title: Liver involvement in Langerhans cell histiocytosis.
abstract: Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction. We present an 11-month-old child having only minimally elevated liver enzymes as an indication of liver involvement. Using sonography as the initial diagnostic tool followed by MRI, LCH of the liver was revealed. A review of sonographic, CT, MRI and MR cholangiopancreatography findings in liver LCH is presented. We recommend that physicians consider sonography and MRI screening for liver involvement in patients with newly diagnosed LCH, as periportal involvement may be present with little or no liver function abnormality present, as in this patient.
authors.affiliation: Department of Diagnostic Imaging, Alberta Children's Hospital, 1820, Richmond Road S.W., Calgary, Alberta, T2T 5C7, Canada.
authors.forename: Adelaine
authors.initials: A
authors.lastname: Wong
authors.forename: Clara L
authors.initials: CL
authors.lastname: Ortiz-Neira
authors.forename: Walid Abou
authors.initials: WA
authors.lastname: Reslan
authors.forename: Raphael
authors.initials: R
authors.lastname: Sharon
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pinto-Rojas
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaura
authors.forename: Ronald
authors.initials: R
authors.lastname: Anderson
mesh_terms: D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008111:Liver Function Tests; D008297:Male