Highly parallel genomic assays.
Recent developments in highly parallel genome-wide assays are transforming the study of human health and disease. High-resolution whole-genome association studies of complex diseases are finally being undertaken after much hypothesizing about their merit for finding disease loci. The availability of inexpensive high-density SNP-genotyping arrays has made this feasible. Cancer biology will also be transformed by high-resolution genomic and epigenomic analysis. In the future, most cancers might be staged by high-resolution molecular profiling rather than by gross cytological analysis. Here, we describe the key developments that enable highly parallel genomic assays.
Fan
Jian-Bing
JB
Illumina Inc., 9885 Towne Centre Drive, San Diego, California 92121, USA.
Chee
Mark S
MS
Gunderson
Kevin L
KL
D015894:Genome, Human; D023281:Genomics / Q000191:economics / Q000379:methods* / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000191:economics / Q000379:methods* / Q000639:trends