title: Transmission of syphilis by solid organ transplantation.
abstract: Two organ recipients developed serologic evidence of syphilis infection after renal transplantation from a common deceased donor with a history of treated syphilis. Testing of donor serum for syphilis, which occurred after transplantation, gave results interpreted as consistent with past infection. However, subsequent serologic results in the recipients suggested transmission of infection at transplantation due to active infection of the donor. This may be explained by recent donor re-infection in view of the current syphilis epidemic in the United Kingdom. An initial error in the treatment of recipients further served to highlight unfamiliarity in managing this resurgent infection in the context of organ transplantation.
authors.affiliation: Department of Microbiology, Southampton General Hospital, Southampton, UK. Nicholas.Cortes@suht.swest.nhs.uk
authors.forename: N J
authors.initials: NJ
authors.lastname: Cortes
authors.forename: B
authors.initials: B
authors.lastname: Afzali
authors.forename: D
authors.initials: D
authors.lastname: MacLean
authors.forename: D J A
authors.initials: DJ
authors.lastname: Goldsmith
authors.forename: H
authors.initials: H
authors.lastname: O'Sullivan
authors.forename: J
authors.initials: J
authors.lastname: Bingham
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
authors.forename: E
authors.initials: E
authors.lastname: MacMahon
authors.forename: C Y W
authors.initials: CY
authors.lastname: Tong
authors.forename: G
authors.initials: G
authors.lastname: Koffman
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D013587:Syphilis / Q000382:microbiology / Q000635:transmission*; D014210:Treponema pallidum / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial