title: Preliminary comparative study of small amplitude helical and conventional ePTFE arteriovenous shunts in pigs.
abstract: Intimal hyperplasia (IH), which causes occlusion of arterial bypass grafts and arteriovenous (A-V) shunts, develops preferentially in low wall shear, or stagnation, regions. Arterial geometry is commonly three-dimensional, generating swirling flows, the characteristics of which include in-plane mixing and inhibition of stagnation. Clinical arterial bypass grafts are commonly two-dimensional, favouring extremes of wall shear. We have developed small amplitude helical technology (SwirlGraft) devices and shown them to generate physiological-type swirling flows. Expanded polytetrafluorethylene (ePTFE) grafts, although widely used as A-V shunts for renal dialysis access, are prone to thrombosis and IH. In a small preliminary study in pigs, we have implanted SwirlGraft ePTFE carotid artery-to-jugular vein shunts on one side and conventional ePTFE carotid artery-to-jugular vein shunts contralaterally. There was consistently less thrombosis and IH in the SwirlGraft than conventional shunts. At eight weeks (two animals), the differences were marked, with virtually no disease in the SwirlGraft devices and occlusion of the conventional grafts by thrombosis and IH. The study had limitations, but the lesser pathology in the SwirlGraft devices is likely to have resulted from their geometry and the associated swirling flow. The results could have implications for vascular biology and prolongation of the patency of arterial bypass grafts and A-V shunts.
authors.affiliation: Department of Bioengineering, Imperial College, London SW7 2AZ, UK. c.caro@ic.ac.uk
authors.forename: Colin G
authors.initials: CG
authors.lastname: Caro
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Cheshire
authors.forename: Nick
authors.initials: N
authors.lastname: Watkins
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000295:instrumentation*; D004867:Equipment Design; D023421:Models, Animal; D011138:Polytetrafluoroethylene; D013552:Swine
chemical_list: D011138:Polytetrafluoroethylene