title: Cell-autonomous and -nonautonomous contributions of STAT1 in murine models of tumorigenesis.
abstract: In this issue of Cancer Cell, Kovacic and colleagues have reexamined the role of STAT1 in murine models of leukemogenesis. Their studies shed new light on the complex interplay between cell-autonomous contributions and host responsiveness to cancer and elucidate a previously unknown role of STAT1 in tumor progression.
authors.affiliation: Howard Hughes Medical Institute, Harvard Medical School, Karp Family Research Laboratories, 1 Blackfan Circle, Room 5210, Boston, Massachusetts 02115,USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Rocnik
authors.forename: D Gary
authors.initials: DG
authors.lastname: Gilliland
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D007942:Leukemia, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D015395:Histocompatibility Antigens Class I; C499308:Rag2 protein, mouse; D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse