Reflex inhibition of heart rate and efferent cardiac sympathetic outflow induced by colorectal distension in anesthetized rats.
Colorectal distensions of 60 and 80 mmHg significantly reduced heart rate (HR) and cardiac sympathetic nerve activity in anesthetized rats. This bradycardiac response was not influenced by the intravenous administration of atropine, but was abolished by propranolol, suggesting that it was elicited by sympathetic but not vagal efferent nerves.
Li
W M
WM
Department of Integrative Medicine, Shanghai Medical College, Fudan University, Shanghai, China. wmli@shmu.edu.cn
Suzuki
A
A
D000319:Adrenergic beta-Antagonists; D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001919:Bradycardia / Q000503:physiopathology; D002404:Catheterization; D003106:Colon / Q000294:innervation* / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D006321:Heart / Q000294:innervation* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum / Q000294:innervation* / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D001285:Atropine; D011433:Propranolol