Effect of interleukin-1beta on NMDA-induced 45Ca2+ uptake by synaptosomes of rat brain cortex.
The effect of interleukin-1beta on presynaptic NMDA receptors was evaluated by studying NMDA-induced 45Ca2+ uptake by synaptosomes from rat brain cortex. Interleukin-1beta inhibited 45Ca2+ uptake by synaptosomes. Our results indicate that interleukin-1beta modulates presynaptic NMDA receptors and is probably involved in the regulation of synaptic transmission in the central nervous system.
Petrova
L N
LN
Laboratory of Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka.
Grigor'ev
V V
VV
Bachurin
S O
SO
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000493:pharmacokinetics*; D002540:Cerebral Cortex / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism
D002132:Calcium Radioisotopes; D007375:Interleukin-1; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate