title: Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal.
abstract: The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug (AED) withdrawal after at least 2 years of seizure control. Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.
authors.affiliation: Department of Neurology, FCM, State University of Campinas-UNICAMP, Brazil.
authors.forename: T A M
authors.initials: TA
authors.lastname: Cardoso
authors.forename: A C
authors.initials: AC
authors.lastname: Coan
authors.forename: E
authors.initials: E
authors.lastname: Kobayashi
authors.forename: C A M
authors.initials: CA
authors.lastname: Guerreiro
authors.forename: L M
authors.initials: LM
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Cendes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D001284:Atrophy / Q000473:pathology; D016009:Chi-Square Distribution; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
chemical_list: D000927:Anticonvulsants