Bioactive glass S53P4 in frontal sinus obliteration: a long-term clinical experience.
BACKGROUND
Synthetic, osteoconductive, and antimicrobial bioactive glass (BAG) has been used in many surgical applications.


METHODS
BAG was used as obliteration material in a series of osteoplastic frontal sinus operations on 42 patients suffering from chronic frontal sinusitis, which could not be cured with other means of treatment.


RESULTS
Accurate obliteration of sinuses was achieved in 39 patients. Uneventful recovery and clinical outcome were seen in 92% of the patients. Histopathologic samples harvested at 1, 5, and 10 years after obliteration revealed a healing process progressing from the fibrous tissue phase to bone formation with scattered fibrous tissue and bony obliteration maintaining BAG granule remnants. Fourier-transform infrared (FTIR) studies showed bone produced by BAG to be similar to natural frontal bone. Micorobiologic cultures obtained with histologic samples revealed no growth of bacteria.


CONCLUSIONS
BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.
Peltola
Matti
M
Department of Otorhinolaryngology, Head and Neck Surgery, Turku University Hospital, FIN-20521 Turku, Finland. matti.peltola@tyks.fi
Aitasalo
Kalle
K
Suonpää
Jouko
J
Varpula
Matti
M
Yli-Urpo
Antti
A
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005624:Frontal Bone / Q000254:growth & development; D005626:Frontal Sinus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D015522:Frontal Sinusitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
C403922:bioactive glass S53P4