title: PELVIS Syndrome.
abstract: BACKGROUND
  Large perineal hemangiomas can be associated with congenital anomalies, including anorectal, urinary tract, spine, and external genitalia malformations.
  
  
  METHODS
  We describe 2 infants with large sacral and perineal hemangiomas, with severe malformation of the external genitalia with ambiguous genitalia in one case and urinary tract malformations and imperforate anus in the other case. These cases are discussed, along with 9 previously reported cases with similar findings.
  
  
  CONCLUSIONS
  Large perineal hemangiomas may constitute a distinctive group of associated anorectal, neurologic, renal or urinary tract, and genital defects. We propose the acronym PELVIS syndrome to emphasize the characteristic findings of this syndrome: perineal hemangioma, external genitalia malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag.
authors.affiliation: Department of Dermatology, Hôpital Saint-Eloi, Centre Hospitalier Régional Universitaire, Montpellier, France. celine-girard@chu-montpellier.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Girard
authors.forename: Michèle
authors.initials: M
authors.lastname: Bigorre
authors.forename: Bernard
authors.initials: B
authors.lastname: Guillot
authors.forename: Didier
authors.initials: D
authors.lastname: Bessis
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000473:pathology; D001006:Anus, Imperforate / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005836:Genitalia, Female / Q000002:abnormalities*; D005837:Genitalia, Male / Q000002:abnormalities*; D006391:Hemangioma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D010502:Perineum / Q000473:pathology; D012445:Sacrococcygeal Region / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome; D014599:Uterus / Q000002:abnormalities