Tandem azidination- and hydroazidination-Huisgen [3 + 2] cycloadditions of ynamides. Synthesis of chiral amide-substituted triazoles.
Tandem azidination- and hydroazidination-Huisgen [3 + 2] cycloadditions of ynamides are described here. These processes are regioselective and chemoselective, leading to the synthesis of chiral amide-substituted triazoles.
Zhang
Xuejun
X
Division of Pharmaceutical Sciences and Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705-2222, USA.
Hsung
Richard P
RP
You
Lingfeng
L
D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis*
D000480:Alkynes; D000577:Amides; D001386:Azides; D014230:Triazoles