Effects of corticoliberin fragment CRF(4-6) on sexual behavior in male rats [corrected].
Centrally administered doses of the tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) suppressed mating behavior in male rats. Doses of 1 and 2 microg of the tripeptide produced dose-dependent increases in the latent periods of mounting, intromission, and ejaculation. Changes in measures of sexual behavior demonstrated that the corticoliberin fragment CRF(4-6) suppressed both sexual motivation and sexual performance.
Andreev-Andrievskii
A A
AA
M. V. Lomonosov Moscow State University, Vorob'evy Gory, 119992 Moscow, Russia.
Tsvirkun
D V
DV
Makarenko
E Yu
EY
Andreeva
L A
LA
Mart'yanov
A A
AA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments; D051381:Rats; D012737:Sex Factors; D012726:Sexual Behavior, Animal / Q000502:physiology*
D010446:Peptide Fragments; D003346:Corticotropin-Releasing Hormone