[Bone tissue in osteogenesis imperfecta: light and electron microscopic studies].
Osteogenesis imperfecta was studied by light and electron microscopic techniques in 36 cases, of them there were 10 postmortem and 26 bone biopsies. The persons' age was from 0 to 38 years. There were 25 males and 11 females. The microscopic studies indicated a decrease in the basic substance and an increase in the number of osteocytes. The electron microscopic studies revealed a reduction in the granular endoplasmic reticulum, as well as matrix swelling in the mitochondria, their crista degeneration, and the presence of mitochondrial hydroxyappatite; non-uniform mineralization of collagenous structures, their disintegration, a change in the diameter of collagenous fibril, and a decrease in their transversal lines.
Osipenkova-Vichtomova
T K
TK
D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000473:pathology* / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D010013:Osteogenesis Imperfecta / Q000473:pathology* / Q000648:ultrastructure