title: Mycosis fungoides in a hemodialysis patient with intractable pruritus.
abstract: A 69-year-old Japanese man developed pruritus 3 years after beginning hemodialysis. Although eczema was not apparent at first, erythematous patches and plaques developed gradually on the affected skin. Secondary hyperparathyroidism was considered to be a main cause of this patient's pruritus, but skin lesions worsened even after parathyroidectomy had markedly decreased parathyroid hormone concentrations. Two months later, he developed an antibiotic-refractory fever of unknown origin and cervical, axillary, and inguinal lymphadenopathy. Elevations of soluble interleukin-2 receptor with 7410 U/mL and IgE with 24 600 U/mL in serum were noted, as was eosinophilia. The skin showed multiple slightly scaly patches and infiltrative plaques, which were reddish brown and distributed widely over the body surface except for the scalp and face. Mycosis fungoides, a cutaneous T-cell lymphoma, was diagnosed from biopsy specimens findings in skin and lymph node. Mycosis fungoides has not been documented as a cause of pruritus in hemodialysis patients. However, if skin lesions steadily worsen in hemodialysis patients, malignant diseases such as mycosis fungoides should be considered.
authors.affiliation: Nephrology Center, Toranomon Hospital, Tokyo, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Miyoshi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tagami
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Son
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Akiko
authors.initials: A
authors.lastname: Kishi
authors.forename: Noriko
authors.initials: N
authors.lastname: Motoi
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications; D008297:Male; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000188:drug therapy; D011701:PUVA Therapy / Q000379:methods*; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology*; D006435:Renal Dialysis / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome