[Immunogenetic blood markers as a risk factor of development of periodic disease in Armenian population].
OBJECTIVE
To reveal characteristic associations between various markers of immunogenetic (HLA--A, B, C, DR), erythrocytic (ABO, Rh-Hr, MNSs, Pp, Kell-Chellano, Lewis), serum (Gm, Inv) systems and familial Mediterranean fever (FMF) in Armenian population.


METHODS
From 41 to 125 patients (depending on systems studied) were examined. HLA-antigens of A-, B-, C-classes were detected by the microcytotoxic test in a total population of lymphocytes, HLA-DR antigens--by a prolonged test in B-lymphocytes, erythrocytic antigens--by hemagglutination technique and indirect Coombs' reaction, serum antigens--by the method of hemagglutination suppression.


RESULTS
Confidential positive associative relations between antigens HLA-A1 and A9 (RR = 2.2 and 2.4), HLA B5 and B35 (RR = 3.03 and 3.2), HLA-Cw4 (RR = 4.3), HLA-DR3 (RR = 2.6), phenotypes AB (RR = 2.86) and MN (RR = 2.2), serum antigen Gmx+ (RR = 2.87) were demonstrated. Simultaneous expression of phenotype MN and antigen Gmx+ is a marker of high predisposition to the disease (RR = 4.7). Negative associative relations were found between FMF and antigens HLA-B12 and B18 (RR = 0.6 and 0.1), HLA DR4 (RR = 0.1) and phenotype MM (RR = 0.37).


CONCLUSIONS
A simultaneous complex investigation of the markers of various immunogenetic systems allows detection of genetic markers of predisposition to FMF (HLA-B5, B35, Cw4, DR3, AB, Gmx+, MN) and the resistance to this disease (HLA-B12, B18, DR4) in a population of Armenians.
Nersisian
V M
VM
Astvatsatrian
V A
VA
Zakharian
A G
AG
Musaelian
N O
NO
Martirosian
I G
IG
D000293:Adolescent; D000328:Adult; D001136:Armenia / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D010505:Familial Mediterranean Fever / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000097:blood* / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D006680:HLA Antigens