title: Oesophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias.
abstract: BACKGROUND
  Oesophageal sensory stimuli alter neurocardiac function through autonomic reflexes.
  
  
  OBJECTIVE
  To evaluate in patients with idiopathic supraventricular cardiac dysrhythmias and gastro-oesophageal reflux disease (GERD) whether GE reflux alters neurocardiac function and the effect of acid suppression on cardiac symptoms.
  
  
  METHODS
  Thirty-two patients (13 females and 19 males; age: 20-69 years) with dysrhythmias plus GERD, and nine patients (five females and four males; age: 43-58 years) with GERD only, underwent simultaneous 24-h pH-metry and ECG monitoring. Power spectrum analysis of heart rate variability (PSHRV) was obtained with both its low frequency (LF, sympathetic modulation) and high frequency (HF, vagal modulation) components. Hourly mean oesophageal pH and LF/HF ratio were correlated. A 3 months full-dosage PPI therapy (esomeprazole 40 mg/day) was prescribed.
  
  
  RESULTS
  In 18 (56%) of the 32 patients with dysrhythmia and in none with GERD only, a significant (P < 0.05) correlation between oesophageal pH and LF/HF ratio (oesophagus-heart correlation) was observed. A significant reduction of cardiac symptoms after PPI therapy was observed only in these patients (13/16 vs. 4/11, P < 0.01).
  
  
  CONCLUSIONS
  This study has identified a subgroup of dysrhythmic patients in whom the oesophageal acid stimulus elicited cardiac autonomic reflexes. In these patients acid suppression seems to improve GERD and cardiac symptoms.
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology, University Federico II, Naples, Italy. rcuomo@unina.it
authors.forename: R
authors.initials: R
authors.lastname: Cuomo
authors.forename: F
authors.initials: F
authors.lastname: De Giorgi
authors.forename: L
authors.initials: L
authors.lastname: Adinolfi
authors.forename: G
authors.initials: G
authors.lastname: Sarnelli
authors.forename: F
authors.initials: F
authors.lastname: Loffredo
authors.forename: E
authors.initials: E
authors.lastname: Efficie
authors.forename: C
authors.initials: C
authors.lastname: Verde
authors.forename: M F
authors.initials: MF
authors.lastname: Savarese
authors.forename: P
authors.initials: P
authors.lastname: Usai
authors.forename: G
authors.initials: G
authors.lastname: Budillon
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D015716:Electrocardiography, Ambulatory; D050782:Esophageal pH Monitoring; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D054328:Proton Pump Inhibitors
chemical_list: D000863:Antacids; D054328:Proton Pump Inhibitors