Review of treatments that can ameliorate nonadherence in patients with schizophrenia.
Nonadherence to medication is one of the major problems in treating patients with schizophrenia. Clinicians can use a variety of assessment strategies to identify patients who are nonadherent, although none of these is completely reliable. Interventions to improve adherence include psychosocial strategies, second-generation oral antipsychotics, and long-acting injectable antipsychotics. Because of the potential for reduced relapse and rehospitalization rates and the availability of second-generation antipsychotics in injectable form, a case is made for using long-acting injectable second-generation antipsychotics, when appropriate, to treat patients with schizophrenia.
Kane
John M
JM
Department of Psychiatry, The Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, NY 11004, USA. psychiatry@lij.edu
D000284:Administration, Oral; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D006801:Humans; D007273:Injections, Intramuscular; D010359:Patient Readmission; D011613:Psychotherapy / Q000379:methods; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D055502:Secondary Prevention; D016896:Treatment Outcome; D016312:Treatment Refusal / Q000523:psychology* / Q000706:statistics & numerical data
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations