[Preparation of atenolol monolithic osmotic pump tablets].
OBJECTIVE
The simplified preparative method and formulation for atenolol monolithic osmotic pump tablets were investigated.


METHODS
The core tablets with an indentation were compressed by the punch with a needle. Osmotic pump tablets were prepared by coating the indented tablets. Similarity factor was used to evaluate formulation of osmotic pump tablets.


RESULTS
The formulation of core tablets and the composition and thickness of coating membrane showed marked effects on drug release. Orifice size of core tablets in the range of 1.00 - 1.14 mm scarcely affected drug release.


CONCLUSIONS
The preparation of osmotic pump tablets was simplified with the exempting of laser drilling. The atenolol monolithic osmotic pump tablets could deliver drug constantly for 24 h.
Liu
Long-Xiao
LX
Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310027, China. liulx@zju.edu.cn
Che
Bin-Jie
BJ
Xu
Qing
Q
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry; D001262:Atenolol / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009995:Osmosis; D011092:Polyethylene Glycols / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D011092:Polyethylene Glycols; D001262:Atenolol