title: Chronic lymphoproliferative disorder with regulatory T-cell phenotype.
abstract: We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Katayama
authors.forename: Shiro
authors.initials: S
authors.lastname: Kubonishi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yukari
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maeda
authors.forename: Noriko
authors.initials: N
authors.lastname: Namba
authors.forename: Taro
authors.initials: T
authors.lastname: Masunari
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Nasu
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ikeda
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015415:Biomarkers / Q000097:blood; D002454:Cell Differentiation; D002908:Chronic Disease; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000097:blood*; D046529:Microscopy, Electron, Transmission; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000378:metabolism / Q000648:ultrastructure; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors