title: Augmentation of cellular immunity by kigamicin D.
abstract: Kigamicin D did not show any immunosuppressive activity in mixed lymphocyte culture reaction and mitogen induced lymphocyte blastogenesis in vitro and graft versus host reaction in vivo. Natural killer cell activity in spleen cells was not affected by oral administration of kigamicin D. Instead, delayed-type hypersensitivity response to sheep red blood cells was stimulated at a broad dosage level. It is concluded that kigamicin D increases cellular immunity to specific antigen.
authors.affiliation: Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. masudat@bikaken.or.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Masuda
authors.forename: Shunichi
authors.initials: S
authors.lastname: Ohba
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawada
authors.forename: Masatomi
authors.initials: M
authors.lastname: Iijima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Michiyo
authors.initials: M
authors.lastname: Osono
authors.forename: Daishiro
authors.initials: D
authors.lastname: Ikeda
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kunimoto
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006087:Graft vs Host Reaction / Q000187:drug effects; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008809:Mice, Inbred C3H; D023421:Models, Animal; D010080:Oxazoles / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
chemical_list: D010080:Oxazoles; C484110:kigamicin D; D004317:Doxorubicin