title: Craniofacial resection for tumors of the nasal cavity and paranasal sinuses: a 25-year experience.
abstract: BACKGROUND
  Craniofacial resection is the established "gold standard" for surgical treatment of tumors affecting the anterior skull base.
  
  
  METHODS
  This study analyzed 308 patients (220 males, 88 females) who had undergone craniofacial resection for sinonasal neoplasia with up to 25-year follow-up.
  
  
  RESULTS
  An overall actuarial survival of 65% at 5 years and 47% at 10 years was found for the cohort as a whole. For patients with malignant tumors, the 5-year actuarial survival was 59%, falling to 40% at 10 years. For patients with benign pathology, the actuarial survival was 92% at 5 years falling to 82% at 10 years. Statistical analysis again identified brain involvement, type of malignancy, and orbital involvement as the 3 most significant prognostic factors.
  
  
  CONCLUSIONS
  Analysis of one of the largest single institution cohorts over a 25-year period provides a baseline against which other approaches such as an entirely endoscopic skull base resection must be judged.
authors.affiliation: Institute of Laryngology and Otology, University College London, 330 Gray's Inn Road, London WC1X 8DA, United Kingdom.
authors.forename: David J
authors.initials: DJ
authors.lastname: Howard
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Lund
authors.forename: William I
authors.initials: WI
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000401:mortality / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000601:surgery*; D011379:Prognosis; D019291:Skull Base; D015996:Survival Rate; D013997:Time Factors