Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand.
Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141-150]. PTX-13 underwent slow deuteration at the 13beta-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.
Miles
Christopher Owen
CO
AgResearch Ltd., Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand. chris.miles@agresearch.co.nz
Wilkins
Alistair L
AL
Hawkes
Allan D
AD
Jensen
Dwayne J
DJ
Selwood
Andrew I
AI
Beuzenberg
Veronica
V
Mackenzie
A Lincoln
AL
Cooney
Janine M
JM
Holland
Patrick T
PT
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004141:Dinoflagellida / Q000737:chemistry* / Q000378:metabolism; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization; D000095702:Polyether Toxins
D005663:Furans; D018942:Macrolides; D008387:Marine Toxins; D011714:Pyrans; C513876:pectenotoxin-13; D000095702:Polyether Toxins; C513877:pectenotoxin-14