Hypoglycaemic effect of Helicteres isora bark extract in rats.
The hypoglycaemic effect of the aqueous extract of the bark of Helicteres isora L. (Sterculiaceae) was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the bark of Helicteres isora L. (100 and 200 mg/kg/p.o.) significantly (P<0.001) reduced the blood glucose levels from 64.5-48.5 and 67-47 mg% 2h after oral administration of bark extract and also significantly lowered the blood glucose in STZ diabetic rats from 68-105 and 66-85.5 mg% 21 days after daily oral administration of the extract (P<0.001). The results suggested that the aqueous extract of bark of Helicteres isora L. possesses a potential hypoglycaemic effect in diabetic rats.
Kumar
G
G
Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamil Nadu 627412, India.
Banu
G Sharmila
GS
Murugesan
A G
AG
Pandian
M Rajasekara
MR
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D023382:Toxicity Tests, Acute
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts