title: Azithromycin failure in Mycoplasma genitalium urethritis.
abstract: We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.
authors.affiliation: Alfred Hospital, Victoria, Australia. cbradshaw@mshc.org.au
authors.forename: Catriona S
authors.initials: CS
authors.lastname: Bradshaw
authors.forename: Jorgen S
authors.initials: JS
authors.lastname: Jensen
authors.forename: Sepehr N
authors.initials: SN
authors.lastname: Tabrizi
authors.forename: Timothy R H
authors.initials: TR
authors.lastname: Read
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Garland
authors.forename: Carol A
authors.initials: CA
authors.lastname: Hopkins
authors.forename: Lorna M
authors.initials: LM
authors.lastname: Moss
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Fairley
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D009175:Mycoplasma Infections / Q000188:drug therapy* / Q000382:microbiology*; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D011804:Quinolines / Q000627:therapeutic use; D017211:Treatment Failure; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D017963:Azithromycin; D000077266:Moxifloxacin