title: The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum.
abstract: One new 1,3-diphenylpropane, viscolin (1), and one new flavanone, (2S)-7,4'-dihydroxy-5,3'-dimethoxyflavanone (2), together with thirty-nine known compounds, which included eleven known flavanones, two chromones, fourteen benzenoids, one inositol, two pyrimidines, four triterpenoids and five steroids, were isolated and characterized from Viscum coloratum. Structures of new compounds were determined by spectral analysis. Among them, viscolin (1) showed the most significant inhibition on superoxide anion generation by human neutrophils in response to fMLP (formyl-L-methionyl-L-leucyl-L-phenylalanine).
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University; Tao-Yuan 333, Taiwan. ylleu@mail.edu.tw
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chung
authors.forename: Pao-Yun
authors.initials: PY
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D028181:Viscum / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; C513809:viscolin; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D011407:Propane