title: Effectiveness of virosomal subunit influenza vaccine in preventing influenza-related illnesses and its social and economic consequences in children aged 3-14 years: a prospective cohort study.
abstract: To evaluate the effectiveness of a virosomal subunit influenza vaccine in preventing influenza-related illnesses and its social and economic consequences in children aged 3-14 years, a prospective cohort study was carried out during the 2004-2005 influenza season in 11 private pediatric clinics in the Barcelona metropolitan area. One dose of a virosomal subunit inactivated influenza vaccine (Inflexal V Berna) was given during September and October 2004 to healthy children aged 3-14 years attended in 5 of the 11 clinics. Who comprised the vaccinated cohort (n=966). The non-vaccinated cohort (n=985) was comprised of children attended in the other six clinics. Informed consent was obtained from all parents. The follow up was performed between 1 November 2004 and 31 March 2005. Using a self-administered questionnaire, information was collected from parents or guardians on any type of acute, febrile respiratory illness suffered by their children during the study period, including antibiotic use, and absence from school or work-loss of parents as a result of the illness. RT-PCR (influenza A+B+C) was carried out on pharyngeal and nasal samples obtained from children attended by pediatricians during this period in these clinics with the following symptoms: fever> or =38.5 degrees lasting at least 72h, cough or sore throat (influenza-like illness). Adjusted vaccination effectiveness was 58.6% (95% CI 49.2-66.3) in preventing acute febrile respiratory illnesses, 75.1% (95% CI 61.0-84.1) in preventing cases of influenza-like illnesses and 88.4% (95% CI 49.2-97.3) in preventing laboratory-confirmed cases of influenza A. The adjusted vaccination effectiveness in reducing antibiotic use (18.6%, 95% CI -4.2 to 3.64), absence from school (57.8%, 95% CI 47.9-65.9) and work-loss of parents (33.3%, 95% CI 8.9-51.2) in children affected by an acute febrile respiratory illness was somewhat lower. Vaccination of children aged 3-14 years in pediatric practices with one dose of virosomal subunit inactivated influenza vaccine has the potential to considerably reduce the health and social burdens caused by influenza-related illnesses.
authors.affiliation: Preventive Medicine Unit, Department of Public Health, School of Medicine, University of Barcelona, Casanova 143, Barcelona, Spain. salleras@ub.edu
authors.forename: L
authors.initials: L
authors.lastname: Salleras
authors.forename: A
authors.initials: A
authors.lastname: Domínguez
authors.forename: T
authors.initials: T
authors.lastname: Pumarola
authors.forename: A
authors.initials: A
authors.lastname: Prat
authors.forename: M A
authors.initials: MA
authors.lastname: Marcos
authors.forename: P
authors.initials: P
authors.lastname: Garrido
authors.forename: R
authors.initials: R
authors.lastname: Artigas
authors.forename: A
authors.initials: A
authors.lastname: Bau
authors.forename: J
authors.initials: J
authors.lastname: Brotons
authors.forename: X
authors.initials: X
authors.lastname: Bruna
authors.forename: P
authors.initials: P
authors.lastname: Català
authors.forename: E
authors.initials: E
authors.lastname: Carreras
authors.forename: D
authors.initials: D
authors.lastname: Cuadra
authors.forename: A
authors.initials: A
authors.lastname: Gatell
authors.forename: S
authors.initials: S
authors.lastname: Millet
authors.forename: J
authors.initials: J
authors.lastname: Oller
authors.forename: E
authors.initials: E
authors.lastname: Raga
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016503:Drug Delivery Systems; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D015164:Vaccines, Inactivated / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D022223:Vaccines, Subunit / Q000009:adverse effects / Q000276:immunology; D022721:Vaccines, Virosome / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D022223:Vaccines, Subunit; D022721:Vaccines, Virosome