Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder.
Results from molecular and pharmacological studies point to involvement of the gene coding for the phosphatidylinositol-4-phosphate 5-kinase type II-alpha (PIP5K2A) in the development of schizophrenia and bipolar affective disorder (BPAD). The PIP5K2A gene locus, which is located on chromosomal region 10p12, has been implicated in the development of both disorders by independent linkage and association studies. On a cellular level, PIP5K2A is an enzyme component of the metabolism of inositol phosphate, which has been considered a potential target for the therapeutic action of lithium in BPAD patients. Given that the PIP5K2A gene is a promising candidate for the development of both disorders, we performed an association study between genetic variants at the PIP5K2A locus and 268 patients with schizophrenia, 260 patients with BPAD and 325 ethnically matched healthy controls. We failed to detect association to either disorder using PIP5K2A gene variants through single-marker and haplotype analysis. Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
Jamra
Rami Abou
RA
Institute of Human Genetics, University of Bonn, Bonn, Germany. rami.aboujamra@uni-bonn.de
Klein
Katrin
K
Villela
Angela Wolf
AW
Becker
Tim
T
Schulze
Thomas G
TG
Schmael
Christine
C
Deschner
Monika
M
Klopp
Norman
N
Illig
Thomas
T
Propping
Peter
P
Cichon
Sven
S
Rietschel
Marcella
M
Nöthen
Markus M
MM
Schumacher
Johannes
J
D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase