title: Functional DNAzymes organized into two-dimensional arrays.
abstract: DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array.
authors.affiliation: Department of Chemistry, New York University, New York 10003, USA.
authors.forename: Alejandra V
authors.initials: AV
authors.lastname: Garibotti
authors.forename: Scott M
authors.initials: SM
authors.lastname: Knudsen
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Ellington
authors.forename: Nadrian C
authors.initials: NC
authors.lastname: Seeman
mesh_terms: D001483:Base Sequence; D021881:DNA, Catalytic / Q000737:chemistry* / Q000235:genetics; D006860:Hydrogen Bonding; D018625:Microscopy, Atomic Force; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D036103:Nanotechnology; D020411:Oligonucleotide Array Sequence Analysis; D013499:Surface Properties
chemical_list: D021881:DNA, Catalytic