Liver involvement in Langerhans cell histiocytosis.
Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction. We present an 11-month-old child having only minimally elevated liver enzymes as an indication of liver involvement. Using sonography as the initial diagnostic tool followed by MRI, LCH of the liver was revealed. A review of sonographic, CT, MRI and MR cholangiopancreatography findings in liver LCH is presented. We recommend that physicians consider sonography and MRI screening for liver involvement in patients with newly diagnosed LCH, as periportal involvement may be present with little or no liver function abnormality present, as in this patient.
Wong
Adelaine
A
Department of Diagnostic Imaging, Alberta Children's Hospital, 1820, Richmond Road S.W., Calgary, Alberta, T2T 5C7, Canada.
Ortiz-Neira
Clara L
CL
Reslan
Walid Abou
WA
Sharon
Raphael
R
Pinto-Rojas
Alfredo
A
Kaura
Deepak
D
Anderson
Ronald
R
D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008111:Liver Function Tests; D008297:Male