Synthesis and HPLC evaluation of carboxylic acid phases on a hydride surface.
Three organic moieties containing carboxylic acid functional groups are attached to a particulate silica surface through silanization/hydrosilation. Two compounds (undecylenic acid and 10-undecynoic acid) have 11 carbon chains and the other is a five-carbon acid (pentenoic acid). Bonding is confirmed through carbon elemental analysis, diffuse reflectance infrared fourier transform spectroscopy, and carbon-13 and silicon-29 CP-MAS NMR spectroscopy. The bonded phases are tested by HPLC using PTH amino acids, nucleic acids, theophylline-related compounds, anilines, benzoic acid compounds, choline, and tobramycin. The latter two compounds are used to investigate the aqueous normal phase properties of the three bonded materials.
Pesek
Joseph J
JJ
Department of Chemistry, California State University, One Washington Square, San Jose, CA 95192, USA. pesek@sjsu.edu
Matyska
Maria T
MT
Gangakhedkar
Surekha
S
Siddiq
Rukhsana
R
D000596:Amino Acids / Q000302:isolation & purification; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D011687:Purines / Q000302:isolation & purification; D011743:Pyrimidines / Q000302:isolation & purification; D012822:Silicon Dioxide; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D000596:Amino Acids; D002264:Carboxylic Acids; D011687:Purines; D011743:Pyrimidines; D012822:Silicon Dioxide