title: [Low molecular heparin for treatment of venous thrombosis in two very low-birth-weight pre-term infants with genetic risk factors].
abstract: We describe the use of low molecular weight heparin to treat venous thrombosis in two very low-birth-weight pre-term infants (GA: 30 and 27 weeks) both with genetic and acquired prothrombotic risk factors. Initially both infants were treated with unfractionated heparin. Since in one infant no effect on the thrombus size was observed and in the other infant there was an increase in size, the anticoagulation therapy was switched to subcutaneously injected low molecular heparin (Enoxaparin). During enoxaparin therapy the anti-Xa-level was carefully monitored and dosages were adjusted accordingly. Partial resolution of the thrombosis was achieved in both infants during enoxaparin therapy. No clot extension or recurrence of thrombosis occurred. An accidental overdose of Enoxaparin (100 times the required dosage) was administered to one infant without any consequences. Our data suggest that the use of low molecular weight heparin (Enoxaparin) for treatment of venous thrombosis in our two preterm infants was practical, safe and effective.
authors.affiliation: Neonatologische Intensivstation der Kinderklinik der Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101 Mainz.
authors.forename: S
authors.initials: S
authors.lastname: Volz
authors.forename: H
authors.initials: H
authors.lastname: Schinzel
authors.forename: N
authors.initials: N
authors.lastname: Keune
authors.forename: M
authors.initials: M
authors.lastname: Neukirch
authors.forename: S
authors.initials: S
authors.lastname: Schmidtke
authors.forename: H
authors.initials: H
authors.lastname: Stopfkuchen
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D017984:Enoxaparin / Q000008:administration & dosage*; D005165:Factor V / Q000235:genetics; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006580:Genetic Carrier Screening; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000235:genetics*; D019102:Infant, Very Low Birth Weight; D007279:Injections, Subcutaneous; D008297:Male; D009154:Mutation / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000188:drug therapy* / Q000235:genetics*; D014310:Triplets; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D017984:Enoxaparin; D005343:Fibrinolytic Agents; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin