Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
In this study we determined whether oxcarbazepine (OXC) could produce local peripheral antinociceptive effects in a rat model of inflammatory hyperalgesia, and whether adenosine receptors were involved. When coadministered with the pro-inflammatory compound concanavalin A, OXC (1000-3000 nmol/paw) caused a significant dose- and time-dependent anti-hyperalgesia. Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A1 receptor antagonist, coadministered with OXC, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results indicate that OXC produces local peripheral anti-hyperalgesic effects, which is mediated via peripheral A1 receptors.
Tomić
M A
MA
Department of Pharmacology, University of Belgrade, Medical Military Academy, Serbia and Montenegro. majat@pharmacy.bg.ac.yu
Vucković
S M
SM
Stepanović-Petrović
R M
RM
Ugresić
N
N
Prostran
M S
MS
Bosković
B
B
D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002110:Caffeine / Q000494:pharmacology; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007839:Functional Laterality / Q000502:physiology; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D000078330:Oxcarbazepine; D017933:Peripheral Nervous System / Q000187:drug effects*; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000187:drug effects*; D014970:Xanthines / Q000494:pharmacology
D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D000927:Anticonvulsants; D043682:Receptor, Adenosine A1; D014970:Xanthines; D002220:Carbamazepine; D002110:Caffeine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D010727:Phosphoric Diester Hydrolases; D000078330:Oxcarbazepine