Expression of complement system regulatory molecules in the endometrium of normal ovulatory and hyperstimulated women correlate with menstrual cycle phase.
The present study describes the temporal expression of complement regulatory molecules membrane cofactor protein (MCP), decay accelerating factor (DAF), CR1, and CD59 in the human endometrium throughout the normal menstrual cycle and in patients submitted to ovarian hyperstimulation. During its proliferative phase, the endometrium expresses MCP, with increased expression during the secretory phase. Phase-dependent expression also was observed for DAF and CD59, mainly in the secretory phase. Expression of CR1 was not detected. These results suggest the presence of complement system activity during the menstrual cycle, with greater expression of regulatory molecules during the secretory phase to protect the epithelial integrity of human endometrium.
Nogawa Fonzar-Marana
Rosana Rita
RR
Department of Gynecology and Obstetrics, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
Ferriani
Rui Alberto
RA
Soares
Sandro Gomes
SG
Cavalcante-Neto
Florêncio Figueiredo
FF
Teixeira
José Eduardo
JE
Barbosa
José Elpídio
JE
D000328:Adult; D018958:CD55 Antigens / Q000378:metabolism*; D018957:CD59 Antigens / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D051916:Membrane Cofactor Protein / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism*; D010060:Ovulation / Q000378:metabolism; D010062:Ovulation Induction; D017463:Receptors, Complement 3b / Q000378:metabolism*
C497857:CD46 protein, human; D018958:CD55 Antigens; D018957:CD59 Antigens; D051916:Membrane Cofactor Protein; D017463:Receptors, Complement 3b; D003165:Complement System Proteins