Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.
OBJECTIVE
To investigate the correlation between expression of CD58 and severity of hepatitis B.


METHODS
The level of soluble CD58 (sCD58) in serum of patients with hepatitis B was detected by enzyme-linked immunosorbent assay. The level of expression of membrane CD58 molecule in PBMC was detected by direct immunofluorescence. The levels of serumal TBIL, DBIL, IBIL, ALT and AST were detected by the automated biochemistry analyzer as well.


RESULTS
The levels of sCD58 in serum and membrane CD58 molecule in PBMC of patients with hepatitis B were significantly higher than that in normal controls (P < 0.05). Level of CD58 was related to the levels of serumal TBIL, DBIL, IBIL, ALT and AST.


CONCLUSIONS
The level of CD58 molecule (in both serum and PBMC form) of patients with hepatitis B is related to the degree of liver damage.
Sheng
Li
L
Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Li
Jie
J
Qi
Bao-Tai
BT
Ji
Yu-Qiang
YQ
Meng
Zhao-Jun
ZJ
Xie
Ming
M
D018968:CD58 Antigens / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation; D006509:Hepatitis B / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D012720:Severity of Illness Index
D018968:CD58 Antigens