title: Resolution of diabetes mellitus but not acromegaly in a cat with a pituitary macroadenoma treated with hypofractionated radiation.
abstract: The use of insulin-like growth factor 1 assays in the diagnosis and subsequent monitoring after radiotherapy of an acromegalic cat with a secretory pituitary adenoma and secondary insulin-resistant diabetes mellitus is described. Diabetes resolved, and exogenous insulin was no longer required for the maintenance of normoglycaemia 10 months after completion of a course of hypofractionated radiotherapy. However, insulin-like growth factor 1 remained elevated, and the cat's size and appetite continued to increase. It is suggested that radiotherapy may decrease growth hormone concentration to a level such that diabetogenic effects are no longer evident but not to a level required to decrease insulin-like growth factor 1 secretion.
authors.affiliation: Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Herts, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Littler
authors.forename: G A
authors.initials: GA
authors.lastname: Polton
authors.forename: M J
authors.initials: MJ
authors.lastname: Brearley
mesh_terms: D000172:Acromegaly / Q000175:diagnosis / Q000209:etiology / Q000532:radiotherapy / Q000662:veterinary*; D000236:Adenoma / Q000175:diagnosis / Q000532:radiotherapy / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy*; D002415:Cats; D003920:Diabetes Mellitus / Q000209:etiology / Q000532:radiotherapy / Q000662:veterinary*; D013006:Growth Hormone / Q000378:metabolism; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D013006:Growth Hormone