[Correlation of photodynamic therapy outcome with choroidal neovascular membrane size].
OBJECTIVE
To show the results of photodynamic therapy according to the size of choroidal neovascular membrane size.


METHODS
A retrospective analysis included 94 patients undergoing photodynamic therapy at University Department of Ophthalmology, Sestre MilosrdniceUniversity Hospital from 2001 till 2005. There were 61 patients with age related macular degeneration (AMD) and 33 patients with high myopia. All patients had a predominantly classic choroidal neovascular membrane. Patients were divided into two subgroups according to the lesion size. The first subgroup included patients with a lesion equal to or less than one disc diameter, and the second subgroup had a lesion greater than one disc diameter. All patients were followed up for a minimum of 3 months.


RESULTS
In the group of patients with AMD statistical analysis showed no significant difference in total closure and decrease in the size of choroid neovascularization (CNV) between the two subgroups. In the group of patients with high myopia a statistically significant difference was found in total closure and decrease in the size of CNV between patients with lesions smaller or equal to one disc diameter and those with lesions greater than one disc diameter. The former group also had better visual outcome.


CONCLUSIONS
The size of CNV was not a prognostic factor in patients with AMD. In patients with high myopia, better outcome was recorded in the subgroup with CNV smaller or equal to one disc diameter.
Vrabec
Romano
R
Klinika za ocne bolesti, Klinicka bolnica Sestre milosrdnice, Zagreb, Hrvatska. romanovrabec@yahoo.com
Vatavuk
Zoran
Z
Bencić
Goran
G
Cima
Ivan
I
Ante
Pentz
P
Mandić
Zdravko
Z
D000328:Adult; D000368:Aged; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy; D008297:Male; D009216:Myopia / Q000150:complications; D010778:Photochemotherapy; D011166:Porphyrins / Q000627:therapeutic use; D016896:Treatment Outcome; D000077362:Verteporfin; D014792:Visual Acuity
D011166:Porphyrins; D000077362:Verteporfin