title: Effects of basic fibroblast growth factor and phenytoin on healing of abdominal wall fascia and colonic anastomoses.
abstract: The aim of this study was to investigate the effects of basic fibroblast growth factor (bFGF) and phenytoin on wound healing in rats compromised by methylprednisone. This study was conducted in four groups consisting of 20 male Wistar rats. Rats in groups 2, 3, and 4 had a daily injection of methylprednisolone 5 mg/kg/day for 15 days. Laparotomy and sigmoid transsection were performed on day 15. In the postoperative period, rats in group 1 received no medication, group 2 received methylprednisolone 5 mg/kg/day intramuscularly, group 3 received bFGF 5 microg/kg on days 1-3 subcutaneously, and group 4 received phenytoin 40 mg/kg/day intraperitoneally. bFGF and phenytoin had a positive effect on tensile strength, hydroxyproline content, and wound healing parameters in abdominal wall fascia. In colonic anastomosis, phenytoin corrected all parameters, but bFGF had no effect.
authors.affiliation: Department of Surgery, Ankara University School of Medicine, Turkey.
authors.forename: Hayrettin Varol
authors.initials: HV
authors.lastname: Günes
authors.forename: Seher
authors.initials: S
authors.lastname: Demirer
authors.forename: Kuzey
authors.initials: K
authors.lastname: Aydinuraz
authors.forename: Ilknur
authors.initials: I
authors.lastname: Kepenekci
authors.forename: Ercüment
authors.initials: E
authors.lastname: Kuterdem
authors.forename: Dikmen
authors.initials: D
authors.lastname: Aribal
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000714:Anastomosis, Surgical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D012809:Colon, Sigmoid / Q000187:drug effects / Q000601:surgery*; D004359:Drug Therapy, Combination; D005205:Fascia / Q000187:drug effects; D000071938:Fasciotomy; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D016222:Fibroblast Growth Factor 2; D010672:Phenytoin; D008775:Methylprednisolone