Oxidative stress in hepatitis C infected end-stage renal disease subjects.
BACKGROUND
Both uremia and hepatitis C infection is associated with increased oxidative stress. In the present study, we aimed to find out whether hepatitis C infection has any impact on oxidative stress in hemodialysis subjects.


METHODS
Sixteen hepatitis C (+) hemodialysis subjects, 24 hepatitis C negative hemodialysis subjects and 24 healthy subjects were included. Total antioxidant capacity, total peroxide level and oxidative stress index were determined in all subjects.


RESULTS
Total antioxidant capacity was significantly higher in controls than hemodialysis subjects with or without hepatitis C infection (all p < 0.05/3), while total peroxide level and oxidative stress index were significantly lower (all p < 0.05/3). Hepatitis C (-) hemodialysis subjects had higher total antioxidant capacity compared to hepatitis C (+) hemodialysis subjects (all p < 0.05/3). Total peroxide level and oxidative stress index was comparable between hemodialysis subjects with or without hepatitis C infection (p > 0.05/3).


CONCLUSIONS
Oxidative stress is increased in both hepatitis C (+) and hepatitis C (-) hemodialysis subjects. However, hepatitis C infection seems to not cause any additional increase in oxidative stress in hemodialysis subjects and it may be partly due to protective effect of dialysis treatment on hepatitis C infection.
Horoz
Mehmet
M
Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey. mehmethoroz@yahoo.com
Bolukbas
Cengiz
C
Bolukbas
Filiz F
FF
Aslan
Mehmet
M
Koylu
Ahmet O
AO
Selek
Sahbettin
S
Erel
Ozcan
O
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010545:Peroxides / Q000097:blood; D006435:Renal Dialysis
D000975:Antioxidants; D010545:Peroxides