Specification of auditory sensitivity by Drosophila TRP channels.
Ears achieve their exquisite sensitivity by means of mechanical feedback: motile mechanosensory cells through their active motion boost the mechanical input from the ear. Examination of the auditory mechanics in Drosophila melanogaster mutants shows that the transient receptor potential (TRP) channel NompC is required to promote this feedback, whereas the TRP vanilloid (TRPV) channels Nan and Iav serve to control the feedback gain. The combined function of these channels specifies the sensitivity of the fly auditory organ.
Göpfert
Martin C
MC
Volkswagen Foundation Research Group, Institute of Zoology, University of Cologne, Weyertal 119, 50 923 Cologne, Germany. m.gopfert@uni-koeln.de
Albert
Jörg T
JT
Nadrowski
B
B
Kamikouchi
A
A
D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000502:physiology*; D006309:Hearing / Q000502:physiology*; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D050051:Transient Receptor Potential Channels
D015220:Calcium Channels; D029721:Drosophila Proteins; C494780:IAV protein, Drosophila; D007473:Ion Channels; C405783:NOMPC protein, Drosophila; C476010:Nan protein, Drosophila; D050051:Transient Receptor Potential Channels