title: A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
abstract: Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, S-431 83 Mölndal, Sweden. Peter.Bach@astrazeneca.com
authors.forename: Peter
authors.initials: P
authors.lastname: Bach
authors.forename: Karolina
authors.initials: K
authors.lastname: Nilsson
authors.forename: Andreas
authors.initials: A
authors.lastname: Wållberg
authors.forename: Udo
authors.initials: U
authors.lastname: Bauer
authors.forename: Lance G
authors.initials: LG
authors.lastname: Hammerland
authors.forename: Alecia
authors.initials: A
authors.lastname: Peterson
authors.forename: Tor
authors.initials: T
authors.lastname: Svensson
authors.forename: Krister
authors.initials: K
authors.lastname: Osterlund
authors.forename: David
authors.initials: D
authors.lastname: Karis
authors.forename: Maria
authors.initials: M
authors.lastname: Boije
authors.forename: David
authors.initials: D
authors.lastname: Wensbo
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C023666:pyridine