Recruited leukocytes and local synthesis account for increased matrix metalloproteinase-9 activity in cerebrospinal fluid of dogs with central nervous system neoplasm.
Matrix metalloproteinases (MMP) 2 and 9 are enzymes known to degrade several protein components of the extracellular matrix. In humans, increased concentrations of these enzymes have been demonstrated in the cerebrospinal fluid (CSF) of subjects affected by many neurological conditions including brain tumours; nevertheless comparative data in dogs are completely lacking. Aim of this study was to investigate these molecules in CSF of dogs diagnosed with CNS neurological diseases. Higher activity of MMP 2 and 9 was revealed in dogs with space occupying lesions of likely neoplastic origin in comparison to dogs with idiopathic epilepsy. Statistical modelling reveals that increased MMP 9 activity is mainly due to leukocytes recruitment and local synthesis.
Turba
Maria Elena
ME
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, via Tolara di sopra 50, 40064, Ozzano Emilia, Bologna, Italy. meturba@vet.unibo.it
Forni
Monica
M
Gandini
Gualtiero
G
Gentilini
Fabio
F
D000818:Animals; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000662:veterinary*; D004283:Dog Diseases / Q000134:cerebrospinal fluid*; D004285:Dogs; D007962:Leukocytes / Q000502:physiology*; D020778:Matrix Metalloproteinase 2 / Q000134:cerebrospinal fluid; D020780:Matrix Metalloproteinase 9 / Q000134:cerebrospinal fluid*; D015233:Models, Statistical
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9