Ara-C induces apoptosis in resting B-CLL cells independent on cell proliferation, but involving Ara-CTP formation and inhibition of RNA synthesis.
Kolb
Jean-Pierre
JP
CNRS UMRS 736 INSERM Résistance et Survie des Cellules Tumorales, Centre de Recherches Biomédicales des Cordeliers, Paris, France. Jean-Pierre.Kolb@bhdc.jussieu.fr
D017209:Apoptosis / Q000187:drug effects*; D001085:Arabinofuranosylcytosine Triphosphate / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D003561:Cytarabine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D012313:RNA / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D012313:RNA