The regulatory role of dendritic cells in the immune tolerance.
Immune homeostasis is important for the protection of a host from pathogen aggression, as well as for preventing autoimmunity. Dendritic cells (DCs), the most potent antigen presenting cells, are critical in innate, adaptive immunity and in central tolerance. Recently, their involvement in peripheral tolerance has been shown. Whether DCs induce immunity or tolerance depends on their state of maturation. Different subsets of tolerogenic DCs have been identified in vivo, either in physiological, or pathological conditions, such as tumors, or GVHD. Moreover, tolerogenic DCs can be generated in vitro, by using different culture conditions, such as IL-10 or TGF-beta. In our study, we obtained tolerogenic DCs, by culturing them in the presence of human mesenchymal stem cells (MSCs).
Li
Yin-Ping
YP
Laboratory of Mechanobiology and Engineering of Cells and Tissues, CNRS UMR 7563, Faculty of Medicine and Unit of Cellular and Tissue Therapy, CHU, Nancy, France.
Latger-Canard
Véronique
V
Marchal
Luc
L
Li
Na
N
Ou-Yang
Jing-Ping
JP
Stoltz
Jean-François
JF
D000818:Animals; D017951:Antigen Presentation; D017690:Cell Transplantation; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology*; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000494:pharmacology; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000378:metabolism
D016207:Cytokines; D007166:Immunosuppressive Agents