title: Multiple doses of cefodizime are necessary for the treatment of Neisseria gonorrhoeae pharyngeal infection.
abstract: A single dose of cefodizime (CDZM), ceftriaxone (CTRX), or spectinomycin (SPCM) is recommended for the treatment of gonococcal urethritis or uterine cervicitis in the era of multidrug-resistant Neisseria gonorrhoeae; namely, cefozopran-resistant N. gonorrhoeae (CZRNG). N. gonorrhoeae pharyngeal infection is not so rare in Japan; however, the proper treatment regimen for this infection is not clear. We previously found that a single dose of CDZM completely eradicated multidrug-resistant N. gonorrhoeae in patients with urethritis and uterine cervicitis, so we tried a single 1.0-g dose of CDZM for the treatment of N. gonorrhoeae pharyngeal infection, including infections with CZRNG. The eradication rate of N. gonorrhoeae from the pharynx was 63.0% with a single 1.0-g dose of CDZM, while the rate for CZRNG with the same dose of CDZM was 38.5%. N. gonorrhoeae was completely eradicated from the pharynx when patients received one or two additional doses of CDZM. Therefore, we concluded that two to three doses of CDZM were necessary for the treatment of N. gonorrhoeae pharyngeal infection including infection with CZRNG.
authors.affiliation: Department of Urology, School of Medicine, University of Occupational and Environmental Health Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. t-matsu@med.uoeh-u.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Muratani
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ikuyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yokoo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ando
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sato
authors.forename: Motoko
authors.initials: M
authors.lastname: Kurashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yanai
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004351:Drug Resistance; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification*; D010608:Pharyngeal Diseases / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002439:Cefotaxime; C033356:cefodizime