Endocrinology: the next 60 years--the helix and the chip.
In the 60 years since C H Li reported the isolation of bovine growth hormone (GH), endocrinologists have seen the widespread use of human GH for statural disorders, the measurement of plasma GH as a diagnostic test, the full development of the somatomedin hypothesis and the molecular details of the function of the GH receptor responsible for regulating somatic growth and metabolism. In diabetes, we have passed from administration of animal insulin to formulations with different release rates, insulin pumps and inhalers, insulin sensitizers and a greater understanding of insulin signalling and insulin resistance through genetically engineered murine models. What might we expect over the next few decades?
Waters
Michael J
MJ
Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia. m.walters@imb.uq.edu.au
D015198:Designer Drugs; D004700:Endocrine System Diseases / Q000188:drug therapy / Q000235:genetics; D004704:Endocrinology / Q000639:trends*; D005544:Forecasting; D006728:Hormones / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011956:Receptors, Cell Surface / Q000737:chemistry
D015198:Designer Drugs; D006728:Hormones; D011956:Receptors, Cell Surface