title: Distant metastasis of prostate cancer: early detection of recurrent tumor with dual-phase carbon-11 choline positron emission tomography/computed tomography in two cases.
abstract: Several types of recurrence may be detected by radiologic assessment after treatment in patients with prostate cancer. However, early detection of distant metastasis using positron emission tomography has so far never been published. We report two patients who underwent hormone therapy or surgical resection for prostate cancer. They developed distant metastases which were detected on whole body [C-11] choline positron emission tomography/computed tomography with significant elevation of serum PSA level. In one patient, recurrent tumor of the supraclavicular node (6 mm) diminished in size after subsequent hormone therapy. Surgical resection of recurrent tumor of the lung (12 mm) was performed in the other patient, the pathology of which confirmed the metastatic adenocarcinoma derived from the prostate. The recurrent tumor can be correctly detected by dual-phase whole body [C-11] choline positron emission tomography/computed tomography.
authors.affiliation: Division of Diagnostic Radiology, National Cancer Center Hospital, Chuo-ku 104-0045, Tokyo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maeda
authors.forename: Ukihide
authors.initials: U
authors.lastname: Tateishi
authors.forename: Motokiyo
authors.initials: M
authors.lastname: Komiyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Terauchi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Moriyama
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Arai
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
authors.forename: Tadao
authors.initials: T
authors.lastname: Kakizoe
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002250:Carbon Radioisotopes; D002794:Choline; D042241:Early Diagnosis; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D049268:Positron-Emission Tomography; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D002250:Carbon Radioisotopes; D017430:Prostate-Specific Antigen; D002794:Choline