title: Clinical and biological features of multiple myeloma involving the gastrointestinal system.
abstract: We report 24 cases of multiple myeloma (MM) with involvement of the gastrointestinal (GI) system. We found a strong association with high A lactate dehydrogenase levels, plasmablastic morphology, and A unfavorable karyotype. GI involvement at the time of initial diagnosis was much rarer than later in the course of the disease. The A median survival after diagnosis of GI involvement was 7 months. Among 13 patients treated with stem cell transplantation, the response rate was 92%, and median progression-free survival was 4 months. We conclude that MM involving the GI system is associated with adverse biological features and with short-lasting remissions, even after A high-dose chemotherapy.
authors.affiliation: Myeloma Institute for Research and Therapy, Division of Gastroenterology, The University of Arkansas for Medical Sciences, 4301 West Markham Street/Slot 776, Little Rock, Arkansas 72205, USA.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Talamo
authors.forename: Federica
authors.initials: F
authors.lastname: Cavallo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zangari
authors.forename: Bart
authors.initials: B
authors.lastname: Barlogie
authors.forename: Choon-Kee
authors.initials: CK
authors.lastname: Lee
authors.forename: Mauricio
authors.initials: M
authors.lastname: Pineda-Roman
authors.forename: Elias
authors.initials: E
authors.lastname: Kiwan
authors.forename: Somashekar
authors.initials: S
authors.lastname: Krishna
authors.forename: Guido
authors.initials: G
authors.lastname: Tricot
mesh_terms: D001706:Biopsy; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D009101:Multiple Myeloma / Q000000981:diagnostic imaging*; D015999:Multivariate Analysis; D014057:Tomography, X-Ray Computed / Q000592:standards; D018608:Ultrasonography, Doppler / Q000379:methods / Q000592:standards*