title: Cardiopulmonary bypass influences the plasma levels of calcitonin gene-related peptides in dogs: effects of hemofiltration and hemodilution.
abstract: Calcitonin gene-related peptides (CGRP), which are potent vasodilators, are elevated during cardiopulmonary bypass (CPB) in humans. We evaluated the plasma levels of CGRP in dogs during CPB with hemofiltration with and without hemodilution. Female beagles were divided into control (n=5) and hemodilution (n=5) groups. The CPB with hemofiltration was performed with or without hemodilution. For the measurement of CGRP, blood samples were collected pre-CPB, during CPB, and post-CPB. The concentrations of CGRP in the hemofiltration solution were measured. Although the CPB elevated the plasma CGRP levels in both groups, its elevation was significant in the hemodilution group when compared to the pre-CPB levels. CGRP levels returned to normal post-CPB. Significant differences were found between the two groups in the CGRP amount in hemofiltration. The results show that hemofiltration should be used during CPB to decrease the plasma levels of CGRP.
authors.affiliation: Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo 060-8648, Japan. isaka_m@hotmail.com
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Isaka
authors.forename: Michiaki
authors.initials: M
authors.lastname: Imamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakuma
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Makino
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shiiya
authors.forename: Keishu
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000097:blood* / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000662:veterinary*; D004285:Dogs; D005260:Female; D006438:Hemodilution / Q000662:veterinary*; D006440:Hemofiltration / Q000662:veterinary*
chemical_list: D015740:Calcitonin Gene-Related Peptide