A cellular automaton model for the migration of glioma cells.
We present a study of in vitro cell migration in two dimensions as a first step towards understanding the mechanisms governing the motility of glioma cells. Our study is based on a cellular automaton model which aims at reproducing the kinetics of a lump of glioma cells deposited on a substrate of collagen. The dynamical effects of cell attraction and motion inertia are introduced through adequate automaton rules. We compare the density profiles given by the model to those obtained experimentally. The result of the best fit indicates a substantial cell-cell attraction due to cell-cell communication through gap junctions (or chemotaxis) and negligible inertia effects during migration. Tracking of individual migrating cells indicates highly convoluted cell trajectories.
Aubert
M
M
GMPIB, Université Paris VII, case 7021, 75251 Paris, France.
Badoual
M
M
Féreol
S
S
Christov
C
C
Grammaticos
B
B
D000465:Algorithms; D000818:Animals; D001973:Bromodeoxyuridine; D002450:Cell Communication; D002465:Cell Movement; D049109:Cell Proliferation; D003198:Computer Simulation; D005109:Extracellular Matrix; D005910:Glioma / Q000473:pathology; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D018874:Spheroids, Cellular; D013552:Swine; D014407:Tumor Cells, Cultured
D001973:Bromodeoxyuridine