title: Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
abstract: Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.
authors.affiliation: Department of Psychology, University of Southern California, Los Angeles 90089-1061, and the Veterans Medical Research Foundation, San Diego, CA, USA. luczak@usc.edu
authors.forename: Susan E
authors.initials: SE
authors.lastname: Luczak
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Glatt
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Wall
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D006801:Humans
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial