title: Chemopreventive potential of Tribulus terrestris against 7,12- dimethylbenz (a) anthracene induced skin papillomagenesis in mice.
abstract: In the present investigation, the chemopreventive potential of aqueous extracts of the root and fruit of Tribulus terrestris (an Ayurvedic medicinal plant) on 7, 12 - dimethylbenz (a) anthracene (DMBA) induced papillomagenesis in male Swiss albino mice was studied. A significant reduction in tumor incidence, tumor burden and cumulative number of papillomas was observed, along with a significant increase in average latent period in mice treated orally with Tribulus terrestris suspension continuously at pre, peri and post-initiation stages of papillomagenesis as compared to the control group treated with DMBA and croton oil alone. Treatment with Tribulus terrestris suspension by oral gavage for 7 days resulted in a significant increase in the reduced glutathione content in the liver (P< 0.001 for both root and fruit extracts). Conversely, lipid peroxidation levels were significantly decreased (P< 0.001).
authors.affiliation: Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302004, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Kumar
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Soni
authors.forename: Shalini
authors.initials: S
authors.lastname: Shukla
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005638:Fruit; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D032444:Tribulus
chemical_list: D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene