title: Causes of anergy in the surgical patient and its relationship to postoperative sepsis.
abstract: Between June 1981 and June 1983 the delayed hypersensitivity response (DHR) was studied in 401 patients considered for major surgical procedure: 320 of these patients underwent surgery. The incidence of sepsis and postoperative mortality was higher in anergic and relative anergic patients than in normal responders (p<0.001). To evaluate whether DHR depression in cancer patients was due to the direct effect of cancer or to tumour-linked malnutrition, the 401 patients were divided into 4 groups: 1) 140 malnourished cancer patients, 2) 51 malnourished non-cancer patients, 3) 120 well-nourished cancer patients and 4) 90 well-nourished non-cancer patients. The mean age was not significantly different for the 4 groups. The results showed a relationship between DHR and nutritional status (p<0.001). The tumour-related DHR impairment disappeared when the cancer and non-cancer patient groups were homogeneous with regard to their nutritional status. Therefore, the tumour was able to determine the DHR depression because of the cancer-linked malnutrition. We did not observe any relationship between local extension of the tumour and lymph node involvement and DHR depression. In 90 well-nourished non-cancer patients the relation between DHR and age was investigated. The incidence of anergy and relative anergy was higher in patients over 59 years than in patients under 60 years (p<0.001).
authors.affiliation: Scientific Institute San Raffaele Hospital, Cattedra di Patologia Chirurgica, University of Milan, Via Olgettina 60, 20132 Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Braga
authors.forename: P
authors.initials: P
authors.lastname: Baccari
authors.forename: M
authors.initials: M
authors.lastname: Cristallo
authors.forename: C
authors.initials: C
authors.lastname: Staudacher
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: S
authors.initials: S
authors.lastname: Scaccabarozzi
authors.forename: S
authors.initials: S
authors.lastname: DiPalo
authors.forename: V
authors.initials: V
authors.lastname: DiCarlo