title: [Two patients with Hantavirus infection in The Netherlands; substantial increase in incidence in neighbouring countries].
abstract: A 12-year-old girl and a 57-year-old woman were admitted with fever, general malaise, abdominal pain, nausea and vomiting. Both patients had acute renal insufficiency based on tubulointerstitial nephritis caused by the genus Hantavirus, which was confirmed by blood tests. Both patients recovered spontaneously. The neighbouring countries of France, Germany and Belgium have recently reported 2- to 7-fold increases in the number of Hantavirus infections. Hantavirus is a zoonotic viral disease that is transmitted by mice and is found in humans worldwide. Infection with Hantavirus is associated with severe renal impairment and thrombocytopenia, which usually resolves spontaneously. Recognition of the clinical signs and targeted serological testing can lead to adequate management of the disease. Diagnosing patients with Hantavirus infections will also help to prevent infections in The Netherlands and track epidemiological changes.
authors.affiliation: Afd. Kindergeneeskunde, E7, Jeroen Bosch Ziekenhuis, Postbus 90153, 5200 ME 's-Hertogenbosch. j.dillingh@jbz.nl
authors.forename: S J
authors.initials: SJ
authors.lastname: Dillingh
authors.forename: P
authors.initials: P
authors.lastname: Jira
authors.forename: G
authors.initials: G
authors.lastname: Morroy
authors.forename: B
authors.initials: B
authors.lastname: Wolters
authors.forename: J
authors.initials: J
authors.lastname: Beutler
authors.forename: P M
authors.initials: PM
authors.lastname: Schneeberger
mesh_terms: D015746:Abdominal Pain / Q000821:virology; D001530:Belgium / Q000453:epidemiology; D002648:Child; D005260:Female; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D018778:Hantavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D051437:Renal Insufficiency / Q000821:virology