Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX.
New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
Oh
Kyung-Ae
KA
Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-606, Republic of Korea.
Yang
Garp Yeol
GY
Jun
Daniel
D
Kuca
Kamil
K
Jung
Young-Sik
YS
D000110:Acetylcholinesterase / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000110:Acetylcholinesterase; D003432:Cross-Linking Reagents; D004987:Ethers; D009946:Organothiophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; C402362:bispyridinium oxime BP12; C009680:VX-agent