[Cancer-protecting genes (tumor-suppressor genes)].
Tumor-suppressor genes protect against the development of cancer. The prototypical tumor-suppressor gene is one that controls G1 to S progression in the cell cycle. However, genes that are involved in DNA-repair or induction of apoptosis also protect against the development of cancer. More generally speaking, tumor-suppressor genes either prevent the introduction of somatic mutations or the amplification of the population of somatic cells carrying mutations. Well-known tumor-suppressor genes that also give rise to inherited cancer disorders are described in the review.
Olsen
Jørgen
J
Københavns Universitet, Institut for Medicinsk Biokemi & Genetik, Panum Instituttet, DK-2200 København N. jolsen@imbg.ku.dk
D017209:Apoptosis / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004261:DNA Replication / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*