Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study.
OBJECTIVE
To identify the risk factors associated with primary open-angle glaucoma (POAG) in the Tajimi Study.


METHODS
Population-based cross-sectional epidemiologic study.


METHODS
One hundred nineteen POAG patients and 2755 controls.


METHODS
Univariate and multivariate comparison of ocular factors and systemic factors between POAG patients and controls.


METHODS
Difference in factors between POAG patients and controls, factors associated with POAG patients, and their odds ratio (OR).


RESULTS
Intraocular pressure (IOP), age, myopia, and history of hypertension differed between POAG patients and controls in univariate analyses. Multivariate analysis with logistic regression with stepwise selection of variables demonstrated that higher IOP (OR, 1.12 [95% confidence interval (CI), 1.04-1.21]), myopia (ORs, 1.85 [95% CI, 1.03-3.31] for low myopia and 2.60 [95% CI, 1.56-4.35] for moderate to high myopia), and older age (OR, 1.06 [95% CI, 1.04-1.08]) were associated with an increased risk of having POAG.


CONCLUSIONS
Although the majority (92%) of POAG patients diagnosed in the Tajimi Study had IOP within the normal range, IOP was still identified as a significant risk factor for POAG. Together with IOP, myopia and age were significant risk factors for having POAG.
Suzuki
Yasuyuki
Y
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
Iwase
Aiko
A
Araie
Makoto
M
Yamamoto
Tetsuya
T
Abe
Haruki
H
Shirato
Shiroaki
S
Kuwayama
Yasuaki
Y
Mishima
Hiromu K
HK
Shimizu
Hiroyuki
H
Tomita
Goji
G
Inoue
Yoichi
Y
Kitazawa
Yoshiaki
Y
D000367:Age Factors; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D007429:Intraocular Pressure; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications; D016017:Odds Ratio; D012307:Risk Factors; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields