[Family incidence of latent autoimmune diabetes in adults--case report].
We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electrolyte depletion, acidosis. However plasma level of C peptide basal and after stimulation with glucagon was reduced. Initially, the patient responded well to sulphonylurea treatment. To test immunological pathogenesis we examine autoimmune markers of diabetes type 1. Autoimmune antibodies (GAD, IAA) were found in patients and her parents, which were until now diabetic type 2. We report this case because incidence of latent autoimmune diabetes in adults is underestimate and rarely diagnosed in clinical practice.
Szepietowska
Barbara
B
Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Białystok. barabara@amb.edu.pl
Szelachowska
Małgorzata
M
Górska
Maria
M
D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D010375:Pedigree
D001323:Autoantibodies; D001786:Blood Glucose; D002096:C-Peptide; C024211:islet cell antibody