title: Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.
abstract: In the present study, a local inflammatory response in white adipose tissue from the nonobese HSL-null mouse model is demonstrated. The protein levels of several well-known markers of inflammation, like TNFalpha and ferritin HC, were highly increased and accompanied by an activation of NFkappaB. A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells.
authors.affiliation: Department of Experimental Medical Science, Lund University, BMC C11, SE-221 84 Lund, Sweden. Ola.Hansson@med.lu.se
authors.forename: Ola
authors.initials: O
authors.lastname: Hansson
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Ström
authors.forename: Nuray
authors.initials: N
authors.lastname: Güner
authors.forename: Nils
authors.initials: N
authors.lastname: Wierup
authors.forename: Frank
authors.initials: F
authors.lastname: Sundler
authors.forename: Peter
authors.initials: P
authors.lastname: Höglund
authors.forename: Cecilia
authors.initials: C
authors.lastname: Holm
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D003433:Crosses, Genetic; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D005695:Galactosephosphates / Q000378:metabolism; D007150:Immunohistochemistry; D007249:Inflammation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010449:Peptide Mapping; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D012697:Serine Endopeptidases / Q000032:analysis; D002787:Sterol Esterase / Q000235:genetics / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D005695:Galactosephosphates; D008840:Microfilament Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D020543:Proteome; D014409:Tumor Necrosis Factor-alpha; C097493:galactitol 3-phosphate; C483826:Capg protein, mouse; D002787:Sterol Esterase; D012697:Serine Endopeptidases; C066932:mast cell protease 4