title: Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells.
abstract: Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC(50) of 10.0 microM and 12.2 microM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.
authors.affiliation: Gifu Pharmaceutical University, Japan.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Iliya
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Ali
authors.initials: A
authors.lastname: Zulfiqar
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Oyama
authors.forename: Hiroko
authors.initials: H
authors.lastname: Murata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects / Q000235:genetics; D029624:Ferns; D018922:HL-60 Cells; D006801:Humans; D007214:Indonesia; D007700:Kinetics; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D018547:Plant Stems; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D004273:DNA, Neoplasm; D010936:Plant Extracts; D013267:Stilbenes