[Mechanisms of action of the stimulators of granulocytopoiesis under cytostatic myelosuppression conditions].
Mechanisms of action of pantogematogen (PG), granulocyte colony-stimulating factor (G-CSF), glycyram, and D-glucuronic asid (D-GA) have been investigated under the conditions of myelosuppression caused by the introduction of cyclophosphane. It is established that the activation of granulocytopoiesis by these preparations is based on various mechanisms: G-CSF directly stimulates the proliferation and differentiation of hemopoietic cells; PG enhances the proliferation of granulocytes due to activation of the regulatory systems; D-GA and glycyram normalize the structural and functional organization of a bone marrow, thus providing intensive maturing of the colony-forming units.
Gur'iantseva
L A
LA
Zhdanov
V V
VV
Udut
E V
EV
Simanina
E V
EV
Khrichkova
T Iu
TIu
Dygaĭ
A M
AM
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001685:Biological Factors / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D020723:Glucuronic Acid / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects*; D019891:Leukopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D018906:Antineoplastic Agents, Alkylating; D001685:Biological Factors; C404022:pantohematogen; D016179:Granulocyte Colony-Stimulating Factor; D020723:Glucuronic Acid; D003520:Cyclophosphamide; D006034:Glycyrrhetinic Acid