title: A universal vaccine for serogroup B meningococcus.
abstract: Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood.
authors.affiliation: Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.
authors.forename: Marzia M
authors.initials: MM
authors.lastname: Giuliani
authors.forename: Jeannette
authors.initials: J
authors.lastname: Adu-Bobie
authors.forename: Maurizio
authors.initials: M
authors.lastname: Comanducci
authors.forename: Beatrice
authors.initials: B
authors.lastname: Aricò
authors.forename: Silvana
authors.initials: S
authors.lastname: Savino
authors.forename: Laura
authors.initials: L
authors.lastname: Santini
authors.forename: Brunella
authors.initials: B
authors.lastname: Brunelli
authors.forename: Stefania
authors.initials: S
authors.lastname: Bambini
authors.forename: Alessia
authors.initials: A
authors.lastname: Biolchi
authors.forename: Barbara
authors.initials: B
authors.lastname: Capecchi
authors.forename: Elena
authors.initials: E
authors.lastname: Cartocci
authors.forename: Laura
authors.initials: L
authors.lastname: Ciucchi
authors.forename: Federica
authors.initials: F
authors.lastname: Di Marcello
authors.forename: Francesca
authors.initials: F
authors.lastname: Ferlicca
authors.forename: Barbara
authors.initials: B
authors.lastname: Galli
authors.forename: Enrico
authors.initials: E
authors.lastname: Luzzi
authors.forename: Vega
authors.initials: V
authors.lastname: Masignani
authors.forename: Davide
authors.initials: D
authors.lastname: Serruto
authors.forename: Daniele
authors.initials: D
authors.lastname: Veggi
authors.forename: Mario
authors.initials: M
authors.lastname: Contorni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Morandi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bartalesi
authors.forename: Vanda
authors.initials: V
authors.lastname: Cinotti
authors.forename: Donatella
authors.initials: D
authors.lastname: Mannucci
authors.forename: Francesca
authors.initials: F
authors.lastname: Titta
authors.forename: Elisa
authors.initials: E
authors.lastname: Ovidi
authors.forename: Jo Anne
authors.initials: JA
authors.lastname: Welsch
authors.forename: Dan
authors.initials: D
authors.lastname: Granoff
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Pizza
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000276:immunology*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D038541:Neisseria meningitidis, Serogroup B / Q000145:classification / Q000276:immunology* / Q000648:ultrastructure; D051381:Rats
chemical_list: D000906:Antibodies; D000942:Antigens, Bacterial; D022401:Meningococcal Vaccines