Clinical inquiries. What best prevents exercise-induced bronchoconstriction for a child with asthma?
Inhaled short-acting beta-agonists (SABAs) are most effective in preventing exercise-induced bronchoconstriction, followed by inhaled mast cell stabilizers and anticholinergic agents (strength of recommendation [SOR]: A, multiple randomized control trials [RCTs]). Less evidence supports the use of leukotriene antagonists and inhaled corticosteroids, either individually or in combination (SOR: B). Underlying asthma, which commonly contributes to exercise-induced bronchoconstriction, should be diagnosed and controlled first (SOR: C).
Preston
Jeffrey
J
University of Colorado, Denver, CO, USA.
Cucuzella
Mark
M
Jamieson
Barbara
B
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D001249:Asthma / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D015444:Exercise; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008407:Mast Cells / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D018680:Cholinergic Antagonists