Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents.
Apomorphine was administered by continuous infusion in the mouse following acute inhibition of oxidative metabolism induced by systemic administration of MPTP, and in the gerbil following transient occlusion of the carotid arteries. The dosage employed was comparable to the one used in the treatment of severe on-off fluctuations in Parkinson's disease. The results show that apomorphine significantly diminishes the striatal lesion caused by MPTP and the size of the infarct associated with the transient global ischemia. These data suggest that apomorphine is neuroprotective, probably by means of an antioxidant effect, at doses that are clinically used. The finding may be relevant to brain ischemia as well to chronic neurodegeneration.
Castri
Paola
P
Department of Neurological Sciences, University of Roma, "La Sapienza", Rome, Italy.
Busceti
Carla
C
Battaglia
Giuseppe
G
Girardi
Francesca
F
Cavallari
Michele
M
Orzi
Francesco
F
Fornai
Francesco
F
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D016893:Carotid Stenosis / Q000150:complications; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005849:Gerbillinae; D007262:Infusions, Intravenous; D020267:MPTP Poisoning / Q000150:complications; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects*; D016896:Treatment Outcome
D018491:Dopamine Agonists; D001058:Apomorphine; D004298:Dopamine