title: Different types of atrophy in the prostate with and without adenocarcinoma.
abstract: OBJECTIVE
  The purpose of this study was to evaluate, according to a classification proposed by a working group, the extent and type of atrophy lesions in radical prostatectomy specimens obtained from patients with prostatic carcinoma and benign prostatic hyperplasia (BPH), and to compare the prevalence and types of atrophy between two investigated groups.
  
  
  METHODS
  Histologic analysis of 1096 slides from 50 patients with carcinoma and 277 slides from 31 patients with BPH was performed to evaluate, according to the new prostatic atrophy classification, the number of foci and type of atrophic lesions.
  
  
  RESULTS
  Age, Gleason grade, and TNM showed no significant correlation with the number of proliferative atrophy (PA) and proliferative inflammatory atrophy (PIA) foci (p>0.05). PIA was significantly more frequent in prostates with carcinoma (1.63 vs 1.27 atrophic lesions per slide) (p<0.001), whereas PA displayed an increased frequency in BPH (2.28 vs 0.76 atrophic lesions per slide) (p<0.001).
  
  
  CONCLUSIONS
  We confirmed that PA and PIA are common findings in prostates with and without carcinoma, but the question of whether inflammation produces tissue damage and PA or whether some other insult induces the tissue damage and atrophy directly, with inflammation occurring secondarily, is still unresolved.
authors.affiliation: Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia. dtomas@kbsm.hr
authors.forename: Davor
authors.initials: D
authors.lastname: Tomas
authors.forename: Bozo
authors.initials: B
authors.lastname: Kruslin
authors.forename: Hermann
authors.initials: H
authors.lastname: Rogatsch
authors.forename: Georg
authors.initials: G
authors.lastname: Schäfer
authors.forename: Mladen
authors.initials: M
authors.lastname: Belicza
authors.forename: Gregor
authors.initials: G
authors.lastname: Mikuz
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D001284:Atrophy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000473:pathology