title: Use of posaconazole in the management of invasive orbital aspergillosis in a cat.
abstract: Orbital infection with Aspergillus fumigatus was diagnosed in a Persian cat that was presented with chronic third eyelid protrusion and exophthalmos. Evidence of nasal, sinus, or disseminated aspergillosis was not detected in this cat. Complete surgical excision of diseased tissues was not possible during orbital exenteration, and infection subsequently extended into the tissues of the oral cavity. Oral therapy with itraconazole and parenteral therapy with amphotericin B were ineffective in resolving the infection. Oral therapy with a novel triazole, posaconazole, was curative.
authors.affiliation: Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
authors.forename: Gillian J
authors.initials: GJ
authors.lastname: McLellan
authors.forename: Susette M
authors.initials: SM
authors.lastname: Aquino
authors.forename: David R
authors.initials: DR
authors.lastname: Mason
authors.forename: Joann M
authors.initials: JM
authors.lastname: Kinyon
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Myers
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D008297:Male; D009916:Orbital Diseases / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole