[The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain].
The influence of a 15-day hypokinesia on the development of anxiety-depression state and quantitative changes in the central GABA-A macromolecular receptor complexes in the rat brain has been investigated under conditions of the despair (forced swim) test. Simultaneously, the effects of well-known nootropic drugs picamilon and piracetam on the dynamics of state parameters in the experimental animals have been evaluated. It was found that hypokinesia led to the development of anxiety and depression accompanied by reduction in the amount of active GABA-A receptors. The injections of piracetam and picamilon showed a tendency to restoration of the number of active GABA-A receptors and to normalization of the behavioral parameters.
Akopian
V P
VP
Balian
L S
LS
Avetisian
N A
NA
D000818:Animals; D001921:Brain / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D018476:Hypokinesia / Q000150:complications* / Q000378:metabolism; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000172:deficiency*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D018697:Nootropic Agents; D011963:Receptors, GABA-A; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; D010889:Piracetam