[Effect of immunostimulatory sequence on the expression of EOTAXIN of experimental allergic rhinitis].
OBJECTIVE
To investigate the effect of CpG DNA applied intraperitoneally on the expression of EOTAXIN of allergic rhinitis model.


METHODS
CpG DNA was injected intraperitoneally to rat at the same time of the basic intraperitoneal immunized. The symptoms, expression of eosinophil (EOS) in nasal cavity and expression of EOTAXIN in the nasal mucosa were measured.


RESULTS
After the CpG DNA was applied, the symptom scores, eosinophil (EOS) in nasal cavity and expression of EOTAXIN were weaken.


CONCLUSIONS
There was great reverse effect of CpG DNA on the foundation of rat model of experimental allergic rhinitis, suppression of EOTAXIN may be one of the mechanisms.
Chen
Jianjun
J
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, 430022, China. jj-c@tom.com
Kong
Weijia
W
Xiang
Jisheng
J
D000818:Animals; D054413:Chemokine CCL11 / Q000378:metabolism*; D004804:Eosinophils / Q000276:immunology; D005260:Female; D007165:Immunosuppression Therapy; D009297:Nasal Mucosa / Q000276:immunology* / Q000378:metabolism; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000378:metabolism
D054413:Chemokine CCL11; D009838:Oligodeoxyribonucleotides