Neurologic toxicity associated with interferon alpha therapy for renal cell carcinoma.
A 67-year-old man received interferon alpha (IFN alpha) therapy for lung metastases of renal cell carcinoma (RCC). Multiple pulmonary metastases disappeared completely. However, neurological toxicity was detected by magnetic resonance imaging (MRI) as abnormal brain lesions. After discontinuation of IFN alpha therapy, his neurological symptoms and abnormal lesions on MRI disappeared completely. Complete remission of RCC has continued, and results of neurological study have remained normal for 5 years after discontinuation of IFN alpha therapy.
Wada
Yoshihiro
Y
Department Of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. yoshiwad@kaiju.medic.kumamoto-u.ac.jp
Kuwahara
Tomohiro
T
Uyama
Eiichiro
E
Nakanishi
Juro
J
Takahashi
Wataru
W
Honda
Jiro
J
Kikukawa
Hiroaki
H
Jinnouchi
Yoshiteru
Y
Ueda
Shoichi
S
D000368:Aged; D002292:Carcinoma, Renal Cell; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D012074:Remission Induction
D016898:Interferon-alpha