title: Relationship between markers of inflammation and brachial-ankle pulse wave velocity in Japanese men.
abstract: The objective of the present study was to examine the relationship between markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, in Japanese men. We studied 269 male subjects (mean age, 53 years) who entered our health check-up program. Subjects who were receiving any medication were excluded from the study. baPWV was measured using a volume-plethysmographic apparatus (Form /ABI; Colin, Co. Ltd., Komaki, Aichi, Japan). In addition to routine laboratory tests including ESR, serum levels of hsCRP were determined by a highly sensitive ELISA technique. baPWV was significantly correlated with age (r = 0.41, P < 0.0001), height (r = - 0.21, P = 0.0006), body weight (r = - 0.17, P = 0.007), mean blood pressure (r = 0.66, P < 0.0001), pulse pressure (r = 0.56, P < 0.0001), heart rate (r = 0.25, P < 0.0001), ln (ESR) (r = 0.20, P = 0.001), fasting blood glucose (r = 0.23, P = 0.0001), and ln (serum hsCRP) (r = 0.23, P = 0.0002). baPWV in the highest tertile of ESR was significantly higher than that in the lowest tertile of ESR (P = 0.005). baPWV in the highest tertile of serum hsCRP was significantly higher than those in the lowest tertile (P = 0.002) and the middle tertile of serum hsCRP (P = 0.02). In multiple regression analysis, baPWV significantly correlated with ln (serum hsCRP) independently of other clinical variables that showed a significant correlation with baPWV. baPWV is significantly associated with serum levels of hsCRP in Japanese men, suggesting that inflammation is involved in arterial stiffening.
authors.affiliation: Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Andoh
authors.forename: Junichi
authors.initials: J
authors.lastname: Minami
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishimitsu
authors.forename: Masami
authors.initials: M
authors.lastname: Ohrui
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsuoka
mesh_terms: D000328:Adult; D000368:Aged; D000842:Ankle / Q000098:blood supply; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001799:Blood Sedimentation; D001916:Brachial Artery / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis*; D004548:Elasticity; D004797:Enzyme-Linked Immunosorbent Assay; D006339:Heart Rate; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009098:Multiphasic Screening / Q000379:methods*; D010991:Plethysmography; D011674:Pulse; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D008055:Lipids; D002097:C-Reactive Protein