Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization.
A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and thermoresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.
Bontempo
Debora
D
Department of Chemistry, University of Rome La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
Masci
Giancarlo
G
De Leonardis
Piero
P
Mannina
Luisa
L
Capitani
Donatella
D
Crescenzi
Vittorio
V
D002236:Carbohydrate Conformation; D005609:Free Radicals / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D005609:Free Radicals; D011134:Polysaccharides