Piperidines: a new class of urease inhibitors.
A variety of piperidines (2-12, 14-26) with variable substituents at N-atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254 microM. The size and electron-donating or -withdrawing effects of substituents influence the activity, which lead to the formation of urease inhibitors.
Khan
Khalid Mohammed
KM
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
Saify
Zafar S
ZS
Arif Lodhi
Muhammad
M
Butt
Naeem
N
Perveen
Shahnaz
S
Maharvi
Ghulam Murtaza
GM
Choudhary
Muhammad Iqbal
MI
Atta-Ur-Rahman
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D014510:Urease / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D010880:Piperidines; D014510:Urease