title: Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study.
abstract: The possible association between phospholipase A2 gene and bipolar mood disorder was examined in 557 bipolar patients and 725 controls (all personally interviewed), recruited from seven countries (Belgium, Bulgaria, Croatia, Germany, Greece, Italy, and UK). The frequencies of the eight alleles that were identified did not differ between patients and control individuals in the whole population, while the power to detect an association based on our sample was relatively high. Some differences were noted among the various ethnic groups, but no significant trends existed, suggesting that population stratification by country may not be responsible for a type II error. On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder.
authors.affiliation: Department of Psychiatry, Athens University Medical School and University Mental Health Research Institute, Greece, and Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium. ddikeos@cc.uoa.gr
authors.forename: Dimitris G
authors.initials: DG
authors.lastname: Dikeos
authors.forename: George N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Isabelle
authors.initials: I
authors.lastname: Massat
authors.forename: Douglas
authors.initials: D
authors.lastname: Blackwood
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Eugenia
authors.initials: E
authors.lastname: Daskalopoulou
authors.forename: Sladjana
authors.initials: S
authors.lastname: Ivezic
authors.forename: Radka
authors.initials: R
authors.lastname: Kaneva
authors.forename: Georgia
authors.initials: G
authors.lastname: Karadima
authors.forename: Cristina
authors.initials: C
authors.lastname: Lorenzi
authors.forename: Vihra
authors.initials: V
authors.lastname: Milanova
authors.forename: Walter
authors.initials: W
authors.lastname: Muir
authors.forename: Markus
authors.initials: M
authors.lastname: Nöthen
authors.forename: Lilijana
authors.initials: L
authors.lastname: Oruc
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Constantin R
authors.initials: CR
authors.lastname: Soldatos
authors.forename: Costas N
authors.initials: CN
authors.lastname: Stefanis
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D020029:Base Pairing; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D005060:Europe; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers; D010741:Phospholipases A; D054467:Phospholipases A2