Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography.
We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39+/-0.73 x 10(-6) cm/s at the epithelial side to 8.63+/-0.27 x 10(-6) cm/s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40 mum.
Ghosn
Mohamad G
MG
Biomedical Engineering Program, University of Houston, N207 Engineering Building 1, Houston, Texas 77204, USA.
Tuchin
Valery V
VV
Larin
Kirill V
KV
D000818:Animals; D004058:Diffusion; D005240:Feasibility Studies; D005947:Glucose / Q000032:analysis* / Q000378:metabolism*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D010539:Permeability; D011817:Rabbits; D012590:Sclera / Q000166:cytology* / Q000378:metabolism*; D014018:Tissue Distribution; D041623:Tomography, Optical Coherence / Q000379:methods*
D005947:Glucose