title: Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial.
abstract: BACKGROUND
  The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.
  
  
  RESULTS
  We randomly allocated 96 patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion into 4 groups. Eighty-two patients completed 6-month follow-up; AMI cell infusion (n=25), AMI control (n=25), OMI cell infusion (n=16), and OMI control group (n=16). In cell infusion groups, PBSCs were mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion. The AMI cell infusion group showed a significant additive improvement in left ventricular ejection fraction (LVEF) and remodeling compared with controls (change of LVEF: +5.1+/-9.1% versus -0.2+/-8.6%, P<0.05; change of end-systolic volume: -5.4+/-17.0 mL versus 6.5+/-21.9 mL, P<0.05). In OMI patients, however, there was no significant change of LVEF and ventricular remodeling in spite of significant improvement of coronary flow reserve after cell infusion. G-CSF-based cell therapy did not aggravate neointimal growth with DES implantation.
  
  
  CONCLUSIONS
  Intracoronary infusion of mobilized PBSCs with G-CSF improves LVEF and remodeling in patients with AMI but is less definite in patients with OMI. G-CSF-based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis.
authors.affiliation: Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Hyun-Jae
authors.initials: HJ
authors.lastname: Kang
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Na
authors.forename: Sung-A
authors.initials: SA
authors.lastname: Chang
authors.forename: Kyung-Woo
authors.initials: KW
authors.lastname: Park
authors.forename: Hyung-Kwan
authors.initials: HK
authors.lastname: Kim
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Kim
authors.forename: Ho-Joon
authors.initials: HJ
authors.lastname: Chang
authors.forename: Whal
authors.initials: W
authors.lastname: Lee
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Kang
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Dae-Won
authors.initials: DW
authors.lastname: Sohn
authors.forename: Kyou-Sup
authors.initials: KS
authors.lastname: Han
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Oh
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Park
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D023903:Coronary Restenosis / Q000517:prevention & control*; D003331:Coronary Vessels; D004343:Drug Implants; D018618:Echocardiography, Doppler, Color; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D006965:Hyperplasia; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D015607:Stents; D013318:Stroke Volume; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D004343:Drug Implants; D016179:Granulocyte Colony-Stimulating Factor