Enzyme elevation in patients with juvenile dermatomyositis and steroid myopathy.
OBJECTIVE
Steroid myopathy can occur in patients with juvenile dermatomyositis (JDM) receiving chronic steroid therapy. We report an elevation of serum muscle enzymes, normal strength by manual muscle testing (MMT), and electromyographic (EMG) findings of steroid myopathy in children with JDM.


METHODS
We prospectively studied children with JDM with a history of chronic steroid use (> 3 mo) and ongoing inflammatory myositis who were referred to our institution.


RESULTS
We identified 5/9 children with JDM receiving longterm high dose steroids who had muscle enzyme elevation with no definable weakness and EMG findings consistent with steroid myopathy. All subjects improved after withdrawal of their steroid therapy.


CONCLUSIONS
Longterm high dose steroids may lead to steroid myopathy with muscle enzyme elevation, previously reported only with acute steroid myopathy. We recommend that muscle derived enzyme levels should not be used to differentiate steroid myopathy from inflammatory myopathies.
Naim
Maryam Y
MY
Division of Pediatric Rheumatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Reed
Ann M
AM
D000293:Adolescent; D002648:Child; D003402:Creatine Kinase / Q000378:metabolism; D003882:Dermatomyositis / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D004798:Enzymes / Q000378:metabolism*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000201:enzymology* / Q000503:physiopathology; D011446:Prospective Studies
D004798:Enzymes; D005938:Glucocorticoids; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase