Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal.
The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug (AED) withdrawal after at least 2 years of seizure control. Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.
Cardoso
T A M
TA
Department of Neurology, FCM, State University of Campinas-UNICAMP, Brazil.
Coan
A C
AC
Kobayashi
E
E
Guerreiro
C A M
CA
Li
L M
LM
Cendes
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D001284:Atrophy / Q000473:pathology; D016009:Chi-Square Distribution; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
D000927:Anticonvulsants