Sweet's syndrome in chronic lymphocytic leukemia associated with neutropenic fever and granulocyte colony stimulation factor.
Granulocyte colony stimulation factor (G-CSF) is commonly used in the treatment of chemotherapy-induced myelosuppression. We report the case of a 62-year-old man with chronic lymphocytic leukemia who presented with neutropenic fever and sepsis. After treatment with G-CSF he developed Sweet's syndrome. Sweet's syndrome is a rare disorder but has been associated with cancer recurrence as well as administration of G-CSF. We present clinical and pathologic images that highlight the salient features of this entity.
Thompson
Michael A
MA
Department of Medical Oncology, M.D. Anderson Cancer Center, Houston, TX 77030, USA. MicThompson@mdanderson.org
Dyson
Senait W
SW
Faderl
Stefan
S
D017809:Fatal Outcome; D005334:Fever / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000139:chemically induced* / Q000473:pathology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor