Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT study.
The purpose of this study was to examine the change of dopamine transporters (DAT) binding in methamphetamine (METH) abusers in a two-week period of abstinence and its association with cognitive function. Seven healthy subjects and seven METH abusers were recruited. At baseline conditions, the values of specific uptake ratio (SUR) of DAT binding measured by single photon emission computed tomography were lower in METH abusers than in controls. After a two-week period of abstinence, DAT binding was partially recovered and there were no statistic differences in SUR between METH abusers and controls. There was a borderline correlation between the changes of DAT binding in the right, but not the left, striatum and the %Error of Wisconsin Card Sorting Test. These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function.
Chou
Yuan-Hwa
YH
Department of Psychiatry, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan. c520608@ms64.hinet.net
Huang
Wen-Sheng
WS
Su
Tung-Ping
TP
Lu
Ru-Band
RB
Wan
Fang-Jung
FJ
Fu
Ying-Kay
YK
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D011854:Radiochemistry / Q000379:methods; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon; D014315:Triterpenes
D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D014315:Triterpenes; C118657:correolide; D008694:Methamphetamine