Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates.
In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.
Freund
Patrick
P
Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland.
Schmidlin
Eric
E
Wannier
Thierry
T
Bloch
Jocelyne
J
Mir
Anis
A
Schwab
Martin E
ME
Rouiller
Eric M
EM
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D002584:Cervix Uteri / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D008251:Macaca; D009043:Motor Activity / Q000187:drug effects*; D009185:Myelin Proteins / Q000276:immunology*; D000070798:Nogo Proteins; D002577:Uterine Cervical Diseases / Q000276:immunology*
D000906:Antibodies; D009185:Myelin Proteins; D000070798:Nogo Proteins