No association of G72 and D-amino acid oxidase genes with schizophrenia.
The genes of D-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-D-aspartate receptor regulation pathway for schizophrenia. In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia. In SNP-based single locus association analyses, neither G72 nor DAAO showed significant association with schizophrenia. Additionally, a three-SNP haplotype in DAAO, and a four-SNP as well as a two-SNP haplotype in G72, showed no significant associations with schizophrenia. These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample.
Liu
Yu-Li
YL
Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan.
Fann
Cathy Shen-Jang
CS
Liu
Chih-Min
CM
Chang
Chien Ching
CC
Wu
Jer-Yuarn
JY
Hung
Shuen-Iu
SI
Liu
Shih-Kai
SK
Hsieh
Ming H
MH
Hwang
Tzung-Jeng
TJ
Chan
Hung-Yu
HY
Chen
Jiahn-Jyh
JJ
Faraone
Stephen V
SV
Tsuang
Ming T
MT
Chen
Wei J
WJ
Hwu
Hai-Gwo
HG
D002352:Carrier Proteins / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D003605:D-Amino-Acid Oxidase / Q000235:genetics* / Q000378:metabolism*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013624:Taiwan
D002352:Carrier Proteins; C475071:DAOA protein, human; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D003605:D-Amino-Acid Oxidase