title: A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation.
abstract: OBJECTIVE
  Duration of weaning from mechanical ventilation may be reduced by the use of a systematic approach. We assessed whether a closed-loop knowledge-based algorithm introduced in a ventilator to act as a computer-driven weaning protocol can improve patient outcomes as compared with usual care.
  
  
  METHODS
  We conducted a multicenter randomized controlled study with concealed allocation to compare usual care for weaning with computer-driven weaning. The computerized protocol included an automatic gradual reduction in pressure support, automatic performance of spontaneous breathing trials (SBT), and generation of an incentive message when an SBT was successfully passed. One hundred forty-four patients were enrolled before weaning initiation. They were randomly allocated to computer-driven weaning or to physician-controlled weaning according to local guidelines. Weaning duration until successful extubation and total duration of ventilation were the primary endpoints.
  
  
  RESULTS
  Weaning duration was reduced in the computer-driven group from a median of 5 to 3 d (p=0.01) and total duration of mechanical ventilation from 12 to 7.5 d (p=0.003). Reintubation rate did not differ (23 vs. 16%, p=0.40). Computer-driven weaning also decreased median intensive care unit (ICU) stay duration from 15.5 to 12 d (p=0.02) and caused no adverse events. The amount of sedation did not differ between groups. In the usual care group, compliance to recommended modes and to SBT was estimated, respectively, at 96 and 51%.
  
  
  CONCLUSIONS
  The specific computer-driven system used in this study can reduce mechanical ventilation duration and ICU length of stay, as compared with a physician-controlled weaning process.
authors.affiliation: Service de Réanimation Médicale, Hôpital Henri Mondor, and Unité INSERM U 651, Université Paris XII, Créteil, France.
authors.forename: Francçois
authors.initials: F
authors.lastname: Lellouche
authors.forename: Jordi
authors.initials: J
authors.lastname: Mancebo
authors.forename: Philippe
authors.initials: P
authors.lastname: Jolliet
authors.forename: Jean
authors.initials: J
authors.lastname: Roeseler
authors.forename: Fréderique
authors.initials: F
authors.lastname: Schortgen
authors.forename: Michel
authors.initials: M
authors.lastname: Dojat
authors.forename: Belen
authors.initials: B
authors.lastname: Cabello
authors.forename: Lila
authors.initials: L
authors.lastname: Bouadma
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodriguez
authors.forename: Salvatore
authors.initials: S
authors.lastname: Maggiore
authors.forename: Marc
authors.initials: M
authors.lastname: Reynaert
authors.forename: Stefan
authors.initials: S
authors.lastname: Mersmann
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
mesh_terms: D000368:Aged; D002985:Clinical Protocols; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000628:therapy*; D012189:Retrospective Studies; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods*