Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.
Clopidogrel is a thienopyridine derivative with a relatively low occurrence of adverse side effects. Increasing evidence, however, suggests that clopidogrel may cause severe liver injury. Until now, five cases of clopidogrel-induced acute hepatitis have been reported. We describe the case of an 80-year-old man who developed symptomatic liver disease 6 weeks after 1x75 mg/day clopidogrel intake as adjunctive antiplatelet therapy for a renal artery stent implantation. Histological examination revealed severe acute hepatitis with extensive hepatocanalicular cholestasis and focal cell necrosis with a preferential zone-3 distribution of hepatic damage. In the present paper, we describe the clinico-histopathological characteristics of a case of clopidogrel-induced acute hepatitis and discuss the current literature.
Höllmüller
Isolde
I
Department of Gastroenterology and Hepatology, Innsbruck Medical University, Austria. isolde_hoellmueller@hotmail.com
Stadlmann
Sylvia
S
Graziadei
Ivo
I
Vogel
Wolfgang
W
D000369:Aged, 80 and over; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology*; D000077144:Clopidogrel; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine