title: A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer.
abstract: The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.
authors.affiliation: Department of Clinical Microbiology, Marmara University School of Medicine, Istanbul, Turkey. nulger@marmara.edu.tr
authors.forename: N Ulger
authors.initials: NU
authors.lastname: Toprak
authors.forename: A
authors.initials: A
authors.lastname: Yagci
authors.forename: B M
authors.initials: BM
authors.lastname: Gulluoglu
authors.forename: M L
authors.initials: ML
authors.lastname: Akin
authors.forename: P
authors.initials: P
authors.lastname: Demirkalem
authors.forename: T
authors.initials: T
authors.lastname: Celenk
authors.forename: G
authors.initials: G
authors.lastname: Soyletir
mesh_terms: D000328:Adult; D000368:Aged; D001427:Bacterial Toxins / Q000235:genetics / Q000633:toxicity*; D001441:Bacteroides fragilis / Q000472:pathogenicity*; D015820:Cadherins / Q000502:physiology; D015179:Colorectal Neoplasms / Q000209:etiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics / Q000633:toxicity*; D008875:Middle Aged
chemical_list: D001427:Bacterial Toxins; D015820:Cadherins; D016209:Interleukin-8; C405031:Bacteroides fragilis toxin; D008666:Metalloendopeptidases