title: [-215G>A; IVS3+2T>C] mutation in the SPINK1 gene causes exon 3 skipping and loss of the trypsin binding site.
authors.forename: K
authors.initials: K
authors.lastname: Kume
authors.forename: A
authors.initials: A
authors.lastname: Masamune
authors.forename: K
authors.initials: K
authors.lastname: Kikuta
authors.forename: T
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000368:Aged; D001665:Binding Sites / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D050500:Pancreatitis, Chronic / Q000235:genetics*; D014357:Trypsin / Q000378:metabolism; D014359:Trypsin Inhibitor, Kazal Pancreatic
chemical_list: D002352:Carrier Proteins; C486642:SPINK1 protein, human; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014357:Trypsin