title: [Effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane in anesthetized dogs and rats].
abstract: OBJECTIVE
  To study the effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane.
  
  
  METHODS
  Cerebral blood stream flux, resistance of blood vessels, blood pressure and heart rate were used as observation indexes in hemodynamics experiment. Artery caliber and the number of capillaries with recovered blood stream were used as observation indexes in microcirculation experiment.
  
  
  RESULTS
  Naoan tablets at dose of 0.5 g x kg(-1) and 1.0 g x kg(-1) could enhance cerebral blood stream flux, decrease resistance of blood vessels, and reduce blood pressure. While no effects on heart rate. Naoan tablet at dose of 0.7 g x kg(-1) and 2.1 g x kg(-1) could increase the number of capillaries with recovered blood stream and enlarge the artery caliber of soft membrane in rats.
  
  
  CONCLUSIONS
  Naoan tablets can improve the indexes of hemodynamics and cerebral microcirculation of soft membrane.
authors.affiliation: Pharmacy College, Changchun University of Traditional Chinese Medicine.
authors.forename: Da-fang
authors.initials: DF
authors.lastname: Zhang
authors.forename: Xiu-hua
authors.initials: XH
authors.lastname: Wang
authors.forename: Li-jing
authors.initials: LJ
authors.lastname: Li
authors.forename: Wen-jing
authors.initials: WJ
authors.lastname: Cai
authors.forename: Ya-jie
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D029745:Codonopsis / Q000737:chemistry; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; C529018:naoan