The effect of intravenous administration of fat emulsion on the flow rate and composition of thoracic duct lymph in the dog.
In seven dogs weighing 17-25 kg, the terminal segment of the thoracic duct was isolated, under total pentobarbital anesthesia, so as to collect lymph continuously before, during and after infusion of a 20% fat emulsion Intralipid (Vitrum). Arterial blood and lymph were withdrawn simultaneously for analysis of total protein, amylase, cholesterol, triglycerides, urea and AST. The lymph flow rate was calculated in ml/min. Compared with the control period, during which a 5% glucose solution was administered, a two-hour infusion of the fat emulsion did not change the lymph flow rate nor the levels of biochemical parameters monitored in lymph. These results distinguish intravenous administration of a fat emulsion from a situation, in which fat is administered orally. The unchanged lymph amylase levels following fat administration suggest that no significant stimulation of external pancreatic secretion occurs after this route of fat administration.
Andel
M
M
Transplantation Research Programme of the Institute for Clinical and Experimental Medicine, Vídenska 800, 140 00 Prague 4, Czechoslovakia.
Nozicková
M
M
Bartos
V
V