Vascular smooth muscle cell senescence in atherosclerosis.
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.
Gorenne
Isabelle
I
Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Kavurma
Mary
M
Scott
Stephen
S
Bennett
Martin
M
D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology*; D016615:Telomere / Q000648:ultrastructure; D001616:beta-Galactosidase / Q000378:metabolism
D001616:beta-Galactosidase