[Antibodies to stuctural proteins of endogenous retrovirus of the HERV-K/HTDV family as markers of human germ cell tumors].
Human germ cell tumors (GCT) have been found to be closely associated with the expression of HERV-K/HTDV proviruses and most patients with GCT produce antibodies to the major HERV-K/HTDV Gag and Env proteins. The findings have shown a strong association of the level of HERV-K/HTDV antibodies with the clinical course of the disease and therapy success, which makes it possible to confirm the fact that viral protein antibodies may be used as an additional marker of GCT.
Seniuta
N B
NB
Kleĭman
A M
AM
Triakin
A A
AA
Karseladze
A I
AI
Shelepova
V M
VM
Tiuliandin
S A
SA
Gurtsevich
V E
VE
D000914:Antibodies, Viral / Q000097:blood*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D045744:Cell Line, Tumor; D018450:Disease Progression; D020077:Endogenous Retroviruses / Q000276:immunology*; D019084:Fluorescent Antibody Technique, Indirect; D015683:Gene Products, gag / Q000276:immunology; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D011533:Proviruses / Q000276:immunology*; D013736:Testicular Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D015683:Gene Products, gag; D014759:Viral Envelope Proteins