Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?
Although BRAF V600 mutations in melanocytic tumors are not UV-signature mutations, it is plausible that they could still arise from error-prone replication of UV-damaged DNA. We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection.
Thomas
Nancy E
NE
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA. nthomas@med.unc.edu
Berwick
Marianne
M
Cordeiro-Stone
Marila
M
D004249:DNA Damage; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014466:Ultraviolet Rays
C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf