title: Bone age and onset of puberty in normal boys.
abstract: Many conditions that delay skeletal maturation also delay the onset of puberty, whereas conditions that accelerate skeletal maturation often hasten the onset puberty, raising the possibility that skeletal maturation influences pubertal onset. To determine whether this concordance is also present in normal children, we analyzed data from 30 normal boys participating in a longitudinal study. Height, weight, and serum testosterone concentrations were assessed every 6 months and bone age (Fels method) every year. Pubertal onset was defined by serum testosterone > or =30 ng/dL. The variability in bone age at onset of puberty was not less than the variability in chronological age. In addition, there was no significant correlation between skeletal advancement and pubertal advancement (r=0.01, P=0.9). Similarly, there was not a significant correlation between pubertal advancement and height age advancement, weight age advancement, or BMI age advancement. Our findings do not support the hypothesis that skeletal maturation directly influences the age of pubertal onset in normal boys.
authors.affiliation: Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1829, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Flor-Cisneros
authors.forename: James N
authors.initials: JN
authors.lastname: Roemmich
authors.forename: Alan D
authors.initials: AD
authors.lastname: Rogol
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Baron
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D015992:Body Mass Index; D001837:Body Weights and Measures / Q000706:statistics & numerical data; D001846:Bone Development; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008954:Models, Biological; D011627:Puberty / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors