title: Synthesis and biological evaluation of manzamine analogues.
abstract: [Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. winkler@sas.upenn.edu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Winkler
authors.forename: Allyn T
authors.initials: AT
authors.lastname: Londregan
authors.forename: Justin R
authors.initials: JR
authors.lastname: Ragains
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry
chemical_list: D000962:Antimalarials; D002227:Carbazoles; C078290:manzamine A; D002738:Chloroquine