title: Acute hepatopathy associated with mitotane administration in a dog.
abstract: An adult dog with a persistent elevation in alkaline phosphatase enzyme activity was started on mitotane for suspected hyperadrenocorticism. One month later, the dog was presented for intermittent anorexia and acute icterus. The dog's liver enzyme activities and total bilirubin were markedly elevated, prothrombin time was prolonged, and blood urea nitrogen and glucose were low. Histopathology revealed marked, centrilobular, hepatocellular loss. After discontinuation of the mitotane, the dog recovered with supportive care and was normal 3 months later, which was consistent with mitotane-associated hepatic failure.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado 80523.
authors.forename: Craig B
authors.initials: CB
authors.lastname: Webb
authors.forename: David C
authors.initials: DC
authors.lastname: Twedt
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008107:Liver Diseases / Q000662:veterinary*; D008939:Mitotane / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D008939:Mitotane