title: Effects of alanyl-glutamine on intestinal adaptation and bacterial translocation in rats after 60% intestinal resection.
abstract: The effects of alanyl-glutamine dipeptide (Ala-Gln)-enriched parenteral nutrition on intestinal mucosa and gut barrier function were investigated. Wistar rats were studied. After moderate surgical stress was induced by 60% resection of the small intestine, the rats were randomized to three groups: the chow group was given standard rat chow; the PN group received standard parenteral nutrition (PN); and the Ala-Gln group received glutamine dipeptide-enriched parenteral nutrition (3% Ala-Gln). Rats were maintained on their respective diets for 8 days. The chow and Ala-Gln groups maintained serum glutamine concentrations, intestinal mucosal thickness and villus height. Bacterial translocation rates in the chow and Ala-Gln groups were 20%, which was significantly less than that in the PN group (70%, P < 0.05). The results indicated that Ala-Gln-enriched parenteral nutrition maintains intestinal adaptation and gut barrier function after massive intestinal resection and parenteral nutrition.
authors.affiliation: Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing100730, Republic of China.
authors.forename: Y W
authors.initials: YW
authors.lastname: Liu
authors.forename: M X
authors.initials: MX
authors.lastname: Bai
authors.forename: Y X
authors.initials: YX
authors.lastname: Ma
authors.forename: Z M
authors.initials: ZM
authors.lastname: Jiang