Cartilage and bone tissue engineering using hydrogels.
Tissue engineering is an emerging field of regenerative medicine which holds promise for the restoration of tissues and organs affected by chronic diseases, age-linked degeneration, congenital deformity and trauma. During the past decade, tissue engineering has evolved from the use of naked biomaterials, which may just replace small area of damaged tissue, to the use of controlled three-dimensional scaffolds in which cells can be seeded before implantation. These cellularized constructs aims at being functionally equal to the unaffected tissue and could make possible the regeneration of large tissue defects. Among the recently developed scaffolds for tissue engineering, polymeric hydrogels have proven satisfactory in cartilage and bone repair. Major technological progress and advances in basic knowledge (physiology and developmental biology) are today necessary to bring this proof of concept to clinical reality. The present review focuses on the recent advances in hydrogel-based tissue engineered constructs potentially utilizable in bone and cartilage regenerative medicine.
Vinatier
C
C
Inserm 791, Nantes, France.
Guicheux
J
J
Daculsi
G
G
Layrolle
P
P
Weiss
P
P
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001698:Biomedical Engineering / Q000379:methods; D001861:Bone Regeneration; D018786:Bone Substitutes; D001842:Bone and Bones / Q000473:pathology; D002356:Cartilage / Q000737:chemistry* / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D018786:Bone Substitutes; D020100:Hydrogels