Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis.
A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 microg/mL, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 microg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.
Wirasathien
Lalita
L
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Pengsuparp
Thitima
T
Moriyasu
Masataka
M
Kawanishi
Kazuko
K
Suttisri
Rutt
R
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development
C513631:2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone; D000890:Anti-Infective Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D047188:Chalcones