Prevalent location of flat dysplastic aberrant crypt foci near lymphoid follicles in the colon of azoxymethane-treated rats.
In the colon of F344 rats treated with 2 x 15 mg/kg body weight of azoxymethane (AOM), the density (number of lesions/cm2/rat) of flat aberrant crypt foci (ACF) was 13-fold higher (p < 0.05) in the surface area of mucosa immediately adjacent to lymphoid follicles compared with the density of these lesions in the rest of the mucosa. A similar prevalent location near lymphoid follicles was observed for tumours, but not for the classic elevated ACF. The lymphoid follicle-associated flat ACF had the same characteristics as those located in the rest of the mucosa: i.e. severe dysplasia and Wnt pathway stimulation.
Paulsen
Jan Erik
JE
Department of Food Toxicology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway. jan.erik.paulsen@fhi.no
Steffensen
Inger-Lise
IL
Olstørn
Hege Benedikte
HB
Alexander
Jan
J
D000818:Animals; D001397:Azoxymethane; D003106:Colon / Q000187:drug effects; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344
D001397:Azoxymethane