Phagosome neutrality in host defense.
Activation of proteases in the phagosomes of neutrophils occurs by neutralization of the phagosomal pH by NADPH oxidase. In this issue, Savina et al. (2006) show that dendritic cell phagosomes also recruit NADPH oxidase but with different results. Here, the neutralization of phagosomal pH reduces protease activity, which preserves antigens for crosspresentation on class I MHC molecules.
Watts
Colin
C
Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH. c.watts@dundee.ac.uk
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D003713:Dendritic Cells / Q000201:enzymology / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007111:Immunity, Cellular / Q000276:immunology*; D019255:NADPH Oxidases / Q000378:metabolism*; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D010447:Peptide Hydrolases / Q000378:metabolism; D010588:Phagosomes / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D019255:NADPH Oxidases; D010447:Peptide Hydrolases