The ubiquitin-proteasome pathway in viral infections.
The cellular biological function of the ubiquitin-proteasome pathway as a major intracellular protein degradation pathway, and as an important modulator for the regulation of many fundamental cellular processes has been greatly appreciated over the last decade. The critical role of the ubiquitin-proteasome pathway in viral pathogenesis has become increasingly apparent. Many viruses have been reported to evolve different strategies to utilize the ubiquitin-proteasome pathway for their own benefits. Here, we review the general background and function of the ubiquitin-proteasome pathway, summarize our current understanding of how viruses use this pathway to target cellular proteins, and finally, discuss the roles of this pathway in enteroviral infection, and the potential therapeutic application of proteasome inhibition in myocarditis.
Gao
Guang
G
Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia-St Paul's Hospital, Vancouver, Canada.
Luo
Honglin
H
D000818:Animals; D017209:Apoptosis; D004769:Enterovirus Infections / Q000378:metabolism; D006801:Humans; D009205:Myocarditis / Q000378:metabolism / Q000821:virology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism*; D014780:Viruses / Q000472:pathogenicity
D025801:Ubiquitin; D014764:Viral Proteins; D046988:Proteasome Endopeptidase Complex