[Use of induced sputum in the investigation of occupational asthma].
The diagnosis of occupational asthma relies mainly on the demonstration of changes in airway calibre and airway responsiveness after exposure to occupational agents in the laboratory or at the workplace. However, spirometry or peak expiratory flow measurements may be open to misinterpretation when they are not performed optimally. As in non-occupational asthma, airway inflammation is one of the main characteristics of occupational asthma. Induced sputum, a non invasive method to assess airway inflammation, has been successfully used in the management of asthma. This article reviews the studies that have investigated and characterized the changes in sputum cell counts occurring in subjects with occupational asthma after exposure to occupational agents in the laboratory or at the workplace in order to assess the place of induced sputum in the investigation of occupational asthma. It also reviews the use of induced sputum during the follow-up of workers with occupational asthma after removal from exposure. This article also describes a new condition identified thanks to the use of induced sputum : occupational eosinophilic bronchitis. In conclusion, induced sputum is a useful tool in the investigation of occupational asthma. Its use on a regular basis in the investigation of occupational asthma also allows for the possibility of diagnosis of overlooked conditions such as occupational eosinophilic bronchitis. Its role in the surveillance of workers at risk to develop occupational asthma remains to be determined.
Lemière
Catherine
C
Université de Montréal, Service de pneumologie et Axe de recherche en santé respiratoire, Hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1S9 Canada. catherine.lemiere@umontreal.ca
Malo
Jean-Luc
JL
D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D006801:Humans; D009784:Occupational Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D010808:Physical Examination; D013183:Sputum / Q000502:physiology*