title: Neurologic manifestations in Sagliker syndrome: uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic renal failure patients.
abstract: Patients with chronic renal failure (CRF) often have signs and symptoms related to fluid and electrolyte disturbances, anemia, malnutrition, bone disease, and gastrointestinal problems. Vascular and neurologic impairment in particular remain an important source of morbidity and mortality in this vulnerable patient population. Sagliker syndrome is a novel syndrome that was recently described in 2004 in patients with CRF and severe and late secondary hyperparathyroidism who suffered from severe skull and facial bone changes, particularly from uglifying human face appearances and neuropsychiatric disorders. The goal of this study was to assess neuropsychiatric manifestations occurring in CRF patients with Sagliker syndrome. Four female and 8 male patients with CRF on regular dialysis at the hemodialysis units of the Internal Medicine Departments around southern Turkey participated in the study. All patients underwent a clinical neurologic examination performed by the same neurologist. Neuropsychiatric signs and symptoms were found in all cases. The results showed that the most frequent neurologic manifestations in CRF patients with Sagliker syndrome were headache, polyneuropathy, cranial neuropathy, fatigue, and psychiatric disorders.
authors.affiliation: Baskent University Adana Teaching and Research Hospital Neurology Department, Adana, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Giray
authors.forename: Yahya
authors.initials: Y
authors.lastname: Sagliker
authors.forename: Ismail
authors.initials: I
authors.lastname: Yildiz
authors.forename: Ilker
authors.initials: I
authors.lastname: Halvaci
authors.forename: Nuray
authors.initials: N
authors.lastname: Paylar
authors.forename: Fatih
authors.initials: F
authors.lastname: Ocal
authors.forename: Mustafa
authors.initials: M
authors.lastname: Balal
authors.forename: Piril Sagliker
authors.initials: PS
authors.lastname: Ozkaynak
authors.forename: Saime
authors.initials: S
authors.lastname: Paydas
authors.forename: Cemal
authors.initials: C
authors.lastname: Sagliker
authors.forename: Hasan Sabit
authors.initials: HS
authors.lastname: Sagliker
authors.forename: Necati
authors.initials: N
authors.lastname: Kiralp
authors.forename: Siddik Momin
authors.initials: SM
authors.lastname: Adam
authors.forename: Mustafa
authors.initials: M
authors.lastname: Esenturk
authors.forename: Erdal
authors.initials: E
authors.lastname: Gocmez
authors.forename: Hulya
authors.initials: H
authors.lastname: Taskapan
authors.forename: Musa
authors.initials: M
authors.lastname: Yuksekgonul
authors.forename: Idris
authors.initials: I
authors.lastname: Emir
authors.forename: Turgay
authors.initials: T
authors.lastname: Guler
authors.forename: Hasan
authors.initials: H
authors.lastname: Yakar
authors.forename: Oktay
authors.initials: O
authors.lastname: Sekin
authors.forename: Erkan
authors.initials: E
authors.lastname: Kayali
authors.forename: Sihli
authors.initials: S
authors.lastname: Caliskan
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Eskiocak
authors.forename: Bulent
authors.initials: B
authors.lastname: Ogruk
authors.forename: Tamer
authors.initials: T
authors.lastname: Guzelyurt
authors.forename: Cemal
authors.initials: C
authors.lastname: Kurt
mesh_terms: D000293:Adolescent; D000328:Adult; D001847:Bone Diseases / Q000150:complications*; D003389:Cranial Nerve Diseases / Q000453:epidemiology; D005147:Facial Bones; D005221:Fatigue; D005260:Female; D006261:Headache / Q000453:epidemiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011115:Polyneuropathies / Q000453:epidemiology; D006435:Renal Dialysis; D013577:Syndrome