title: Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds.
abstract: A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents.
authors.affiliation: Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Christiana
authors.initials: C
authors.lastname: Hadjipavlou
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Kostakis
authors.forename: Nicole
authors.initials: N
authors.lastname: Pouli
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Marakos
authors.forename: Harris
authors.initials: H
authors.lastname: Pratsinis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kletsas
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000235:genetics; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000633:toxicity*; D015394:Molecular Structure; D009564:Nitracrine / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000633:toxicity
chemical_list: D007211:Indoles; D014966:Xanthenes; D009564:Nitracrine; D004247:DNA