Tako-Tsubo-like syndrome during anaphylactic reaction.
Tako-Tsubo's syndrome (apical ballooning or broken heart syndrome) is a reversible left ventricular dysfunction due to apical asynergy that occurs typically after sudden emotional stress in a subject without coronary disease. It is characterized by acute onset of chest pain or dyspnoea or both and is associated with electrocardiographic changes such as ST segment elevation and/or T wave inversion. Myocardial biomarkers may be normal or slightly elevated. Anaphylaxis is a severe, life-threatening, generalized hypersensitivity reaction, most often starting with urticaria and/or angioedema, that may involve cardiovascular and respiratory systems. Cardiovascular symptoms, including hypotension, cardiac arrhythmia and chest pain, are presumably linked to cardiac mast cell mediator release. We describe the case of a young woman who experienced a profound reversible cardiomyopathy with typical features of Tako-Tsubo's syndrome during an anaphylactic reaction.
Vultaggio
Alessandra
A
Department of Biomedicine, Unit of Immunology and Cellular Therapy, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy. alevultaggio@hotmail.com
Matucci
Andrea
A
Del Pace
Stefano
S
Simonetti
Ignazio
I
Parronchi
Paola
P
Rossi
Oliviero
O
Maggi
Enrico
E
Gensini
Gianfranco
G
Romagnani
Sergio
S
D000328:Adult; D000707:Anaphylaxis / Q000150:complications*; D001706:Biopsy; D002637:Chest Pain; D017023:Coronary Angiography; D004417:Dyspnea; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D012307:Risk Factors; D013577:Syndrome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology*