title: Pneumocystis jirovecii pneumonia in African miners at autopsy.
abstract: METHODS
  Deceased miners from South Africa whose cardio-respiratory organs were submitted for autopsy for compensation for occupational lung diseases from 1996 to 2000.
  
  
  OBJECTIVE
  1) To document the incidence of Pneumocystis jirovecii pneumonia (PJP) in autopsied miners; 2) to compare the incidence of PJP over a 5-year period; 3) to record the incidence of concomitant lower respiratory tract infection in a group of PJP-infected deceased miners coming to autopsy from 1996 to 2000; and 4) to describe the accuracy of the in-life diagnosis of PJP in this group.
  
  
  METHODS
  Case series of 328 deceased Black miners with histological evidence of PJP at autopsy.
  
  
  RESULTS
  Of the 328 miners with PJP at autopsy, 107 (32.6%) had a concomitant respiratory infection, the most common being cryptococcal pneumonia (46.7%), followed by bacterial pneumonia (34.6%) and pulmonary tuberculosis (13.1%). Overall, Pneumocystis pneumonia was unsuspected prior to death in 89% of cases; however, diagnostic accuracy in life improved from 7% in 1996 to 21% in 2000.
  
  
  CONCLUSIONS
  The high rate of undiagnosed PJP is cause for concern. Clinicians should have a heightened awareness for PJP in Africa, particularly as the disease is treatable at low cost and effective prophylaxis is available.
authors.affiliation: Respiratory Unit, Chris Hani Baragwanath Hospital, Johannesburg, South Africa.
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: P
authors.initials: P
authors.lastname: Back
authors.forename: G
authors.initials: G
authors.lastname: Candy
authors.forename: G
authors.initials: G
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Murray
mesh_terms: D001344:Autopsy; D006801:Humans; D008906:Mining; D045363:Pneumocystis carinii / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology* / Q000473:pathology; D013019:South Africa / Q000453:epidemiology