title: Diffuse cerebral vasoconstriction (Call-Fleming syndrome) and stroke associated with antidepressants.
abstract: Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.
authors.affiliation: Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Noskin
authors.forename: Elham
authors.initials: E
authors.lastname: Jafarimojarrad
authors.forename: Richard B
authors.initials: RB
authors.lastname: Libman
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008875:Middle Aged; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents