title: The prognostic impact of the extent of lymph node dissection in patients with stage III melanoma.
abstract: OBJECTIVE
  To analyse disease-free and overall survival in 67 melanoma patients who underwent dissection for clinically apparent regional lymph node metastases, taking into account the total number of excised lymph nodes.
  
  
  METHODS
  After a median follow-up time of 16 months, 47 recurrences were observed and 43 patients died. The median disease-free and overall survival intervals were 14 and 24 months respectively.
  
  
  RESULTS
  Multivariate analyses revealed that the number of excised lymph nodes had a significant impact on overall survival (P=0.036) but not on disease-free survival (P=0.97). Extranodal growth was the only statistically significant prognostic factor both for disease-free (P=0.005) and overall (P=0.038) survival. Age, nodal basin, primary tumor ulceration, tumor thickness and number of positive lymph nodes were not significant prognostic factors.
  
  
  CONCLUSIONS
  Our results suggest that the total number of lymph nodes excised in the dissection has impact on overall survival of stage III melanoma patients and should be considered in clinical assays.
authors.affiliation: Department of Dermatology, University Hospital, 2 Boulevard Marechal de Lattre de Tassigny, F-21033 Dijon, France. chrystele.galliot@chu-dijon.fr
authors.forename: C
authors.initials: C
authors.lastname: Galliot-Repkat
authors.forename: R
authors.initials: R
authors.lastname: Cailliod
authors.forename: O
authors.initials: O
authors.lastname: Trost
authors.forename: A
authors.initials: A
authors.lastname: Danino
authors.forename: E
authors.initials: E
authors.lastname: Collet
authors.forename: D
authors.initials: D
authors.lastname: Lambert
authors.forename: P
authors.initials: P
authors.lastname: Vabres
authors.forename: S
authors.initials: S
authors.lastname: Dalac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology*; D013534:Survival