H2-M3-restricted T cell response to infection.
H2-M3 is a major histocompatibility complex class Ib molecule that presents N-formylated peptides to specific CD8+ T cells. Prokaryotic, but not eukaryotic, translation begins with the addition of N-formyl methionine, suggesting a role for these H2-M3-restricted T cells in response to bacterial infection. Indeed, these cells constitute a non-redundant "early" component of anti-microbial response.
Colmone
Angela
A
Department of Pathology, University of Chicago, JFK R422 924 E 57th St., Chicago, IL 60637, USA.
Wang
Chyung-Ru
CR
D000818:Animals; D017951:Antigen Presentation; D001424:Bacterial Infections / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology*
C078177:H2-M3 antigen; D015395:Histocompatibility Antigens Class I