title: Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa?
abstract: Adenocarcinomas of the lower genital tract are rare diseases, and most of them arise from the Bartholin glands. Villoglandular adenocarcinoma of intestinal type is a very uncommon neoplasm of unknown origin with only few cases described on the vulva and in the vagina. It is characterized by villoglandular architecture, mucinous-type epithelium with intestinal differentiation (goblet cells), and direct apposition of the tumor with the surface epithelium. We report a case that developed on the hymen of a 64-year-old woman and discuss its possible origin as arising de novo from the squamous epithelium.
authors.affiliation: Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Valérie
authors.initials: V
authors.lastname: Dubé
authors.forename: Gordon M
authors.initials: GM
authors.lastname: Lickrish
authors.forename: Karen Nicole
authors.initials: KN
authors.lastname: MacNeill
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Colgan
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002278:Carcinoma in Situ / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006924:Hymen / Q000473:pathology*; D008875:Middle Aged; D019522:Vaginal Discharge / Q000209:etiology; D014846:Vulvar Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery