Size matters: the prognostic implications of large and small deletions of the derivative 9 chromosome in chronic myeloid leukemia.
Deletions of the derivative 9 chromosome (der(9)) are associated with poor prognosis in chronic myeloid leukemia (CML). Several models have been proposed to account for this association. To distinguish between the various models we mapped the deletion in 69 Philadelphia-positive CML patients carrying a der(9) deletion and compared the size of the deletion with the patients' outcome. Our results demonstrate that patients with large deletions had a significantly worse survival than those with small deletions whereas the outcome for patients with small deletions was similar to that of patients lacking a deletion. These results support the tumor suppressor gene model for the pathogenesis of der(9) deletions, argue against alternative models and provide insight into candidate gene location.
Fourouclas
Nasios
N
Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.
Campbell
Peter J
PJ
Bench
Anthony J
AJ
Swanton
Soheila
S
Baxter
E Joanna
EJ
Huntly
Brian Jp
BJ
Green
Anthony R
AR
D002899:Chromosomes, Human, Pair 9; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology / Q000235:genetics*; D008957:Models, Genetic; D011379:Prognosis; D017384:Sequence Deletion