title: Prick-test evaluation to anaesthetics in patients attending a general allergy clinic.
abstract: OBJECTIVE
  To analyse the prevalence of positive prick-tests to all medicaments normally checked in allergy units when a patient is suspected of being allergic to anaesthetics. To establish the degree of agreement between the antecedents of a previous history of an allergic reaction to a medicament and the positive result, or not, to the specific prick-test for the said medicament.
  
  
  METHODS
  This was a prospective study, during 2003 and 2004, which analysed 473 patients referred by their doctors to allergy units to make retrospective diagnoses of an allergy to a drug. The prick-test was done using the undiluted drug. All patients were tested for 41 drugs. These include antibiotics, trimethoprim-sulphamethoxazole, non-steroidal anti-inflammatory drugs (NSAIDs) and perioperative drugs (PD): neuromuscular blocking drugs, latex, iodine, local anaesthetics, hypnotics, opioids and coadjuvants. Cohen's Kappa Index was used to determine the degree of agreement.
  
  
  RESULTS
  71.5% of patients studied presented a positive prick-test. The largest number of positive cases was found in antibiotics (56.4%), followed by PD (15.6%), NSAIDs (14.4%) and trimethoprim-sulphamethoxazole (12.7%). Among PD, the highest prevalence of positive prick-tests was found for neuromuscular blocking drugs (5.3%). Agreement between the substance suspected of causing the allergic reaction and the positive prick-test was excellent for penicillin (Kappa = 0.74) and other antibiotics (Kappa = 0.721) and good for NSAIDs (Kappa = 0.47) and iodine (Kappa = 0.54).
  
  
  CONCLUSIONS
  The prevalence of patients with positive prick-tests to PD occurred in 15.6% in this prospective cohort. Neuromuscular blocking drugs were found to have the highest prevalence of positive prick-tests. There is positive agreement when the substance responsible for the allergic reaction is suspected, otherwise agreement is low.
authors.affiliation: Valladolid University Hospital, Department of Anaesthesiology and Reanimation, Valladolid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Tamayo
authors.forename: G
authors.initials: G
authors.lastname: Rodríguez-Ceron
authors.forename: J I
authors.initials: JI
authors.lastname: Gómez-Herreras
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Castrodeza
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez
mesh_terms: D000328:Adult; D000368:Aged; D000486:Allergy and Immunology; D000707:Anaphylaxis; D000776:Anesthesiology / Q000379:methods*; D000777:Anesthetics / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012882:Skin Tests / Q000379:methods*
chemical_list: D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal