The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum.
One new 1,3-diphenylpropane, viscolin (1), and one new flavanone, (2S)-7,4'-dihydroxy-5,3'-dimethoxyflavanone (2), together with thirty-nine known compounds, which included eleven known flavanones, two chromones, fourteen benzenoids, one inositol, two pyrimidines, four triterpenoids and five steroids, were isolated and characterized from Viscum coloratum. Structures of new compounds were determined by spectral analysis. Among them, viscolin (1) showed the most significant inhibition on superoxide anion generation by human neutrophils in response to fMLP (formyl-L-methionyl-L-leucyl-L-phenylalanine).
Leu
Yann-Lii
YL
Graduate Institute of Natural Products, College of Medicine, Chang Gung University; Tao-Yuan 333, Taiwan. ylleu@mail.edu.tw
Hwang
Tsong-Long
TL
Chung
Yu-Ming
YM
Hong
Pao-Yun
PY
D000293:Adolescent; D000328:Adult; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D028181:Viscum / Q000737:chemistry*
D001713:Biphenyl Compounds; C513809:viscolin; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D011407:Propane