title: Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.
abstract: A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Wathier
authors.forename: C Starck
authors.initials: CS
authors.lastname: Johnson
authors.forename: Terry
authors.initials: T
authors.lastname: Kim
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D016039:Corneal Transplantation; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D020100:Hydrogels; D010455:Peptides; D011092:Polyethylene Glycols