[Experimental study of Bailian Caogen granule on pharmacodynamics].
OBJECTIVE
To study the analgesic, antipyretic and anti-inflammatory effect of Bailian Caogen granule.


METHODS
The antipyretic effects of Bailian Caogen granule was evaluated in rabbit fever model induced by peptone. The analgesic effect of the drug was studied with pain model of mice induced by acetic acid and hot plate, The severity of oedema in inflamed animal was observed to study the anti-inflammatory effects of Bailian Caogen granule.


RESULTS
Bailian Caogen granule could obviously inhibit the fever of rabbits. The number of writhing induced by acetic acid was reduced and the pain threshold of mice was increased by Bailian Caogen granule. Bailian Caogen granule also had anti-inflammatory activity against xylene-induced mouse ear swelling and carrageenin-induced rat paw edema.


CONCLUSIONS
Bailian Caogen granule has significant analgesic, antipyretic and anti-inflammatory activities.
Zhao
Run-ying
RY
Dept of Pharmacology, Shenyang Medical College, China.
Zhao
Li-ni
LN
Zhou
Yan-xiang
YX
Li
Da-man
DM
Hao
Wei
W
Chen
Kui-min
KM
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D039323:Coptis / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005334:Fever / Q000503:physiopathology / Q000517:prevention & control; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D006358:Hot Temperature; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D017288:Pain Threshold / Q000187:drug effects; D032102:Phellodendron / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C529017:bailian caogen; D019342:Acetic Acid