Electrostatic repulsion as an additional selectivity factor in asymmetric proline catalysis.
The metal free, single amino acid-catalyzed asymmetric desymmetrization (ADS) of meso-compounds with nitrosobenzene has been investigated using DFT. In this communication, we describe the role of electrostatic and dipole-dipole interactions in amino acid-catalyzed reactions, which has not previously been invoked in discussions of these important reactions.
Joseph
Jorly
J
School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India.
Ramachary
Dhevalapally B
DB
Jemmis
Eluvathingal D
ED
D002384:Catalysis; D003198:Computer Simulation; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D055672:Static Electricity
D011392:Proline