Livedoid dermatitis and severe necrosis (Nicolau's syndrome) after intramuscular hydroxyzine injection.
Nicolau's syndrome, also called embolica cutis medicamentosa, is characterized by well- circumscribed livedoid dermatitis with aseptic necrosis after intramuscular injection. We report the case of a 45-year-old woman with severe necrosis of the thigh several days after a routine intramuscular injection of hydroxyzine who was transferred to and treated at our Regional Burn Center. Although there has been one case report and numerous voluntarily reported instances of intramuscular hydroxyzine-induced necrosis to the Food and Drug Administration Spontaneous Reporting System, this phenomenon is rare.
Gayken
Jon
J
University of Minnesota, Minneapolis, Minnesota 55101-2595, USA.
Westanmo
Anders
A
Knutsen
Amy
A
Ahrenholz
David H
DH
Mohr
William J
WJ
Solem
Lynn D
LD
D000982:Antipruritics / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000009:adverse effects*; D007273:Injections, Intramuscular; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced; D012867:Skin / Q000473:pathology*; D013577:Syndrome; D013848:Thigh
D000982:Antipruritics; D006919:Hydroxyzine