The PFAPA syndrome in oral medicine: differential diagnosis and treatment.
Periodic fever syndromes in children can present with orofacial manifestations which contribute to the formulation of a differential diagnosis. Because of the early onset of oral lesions in these syndromes, the oral medicine practitioner may be required to assist in their diagnosis and management. The periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome has been classified as a type of periodic fever syndrome ocurring in early childhood. This article presents a review of the published literature on this entity and summarizes current therapeutic options.
Pinto
Andres
A
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Robert Schattner Center, 240 S. 40th Street St. 214, Philadelphia, PA 19104, USA. apinto@pobox.upenn.edu
Lindemeyer
Rochelle G
RG
Sollecito
Thomas P
TP
D000700:Analgesics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005334:Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008199:Lymphadenitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010507:Periodicity; D010612:Pharyngitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006635:Histamine H2 Antagonists; D002927:Cimetidine