title: A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia.
abstract: E-selectin, which is a member of the selectin superfamily of adhesion molecules, contributes to the leukocyte-endothelial cell attachments and is involved in the pathogenesis of thrombovascular diseases as a consequence. We investigated the A561C mutation in the E-selectin gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 301 age- and sex-matched healthy controls. Excluding the subjects with diabetes mellitus and hypercholesterolemia, the AC genotype frequencies of patients with ischemic CVD were higher than those of controls: 12.7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.
authors.affiliation: Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160-8582, Japan. hidehatt@1999.jukuin.keio.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hattori
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ito
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Murata
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002448:Cell Adhesion / Q000235:genetics; D002536:Cerebral Arteries / Q000378:metabolism* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000235:genetics; D048909:Diabetes Complications / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D020767:Intracranial Thrombosis / Q000208:ethnology / Q000235:genetics / Q000378:metabolism; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019040:E-Selectin