title: Office-based optical coherence tomographic imaging of human vocal cords.
abstract: Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the larynx during surgical endoscopy. The design of an OCT sampling device capable of capturing images of the human larynx during a typical office based laryngoscopy examination is discussed. Both patient's and physician's movements were addressed. In vivo OCT imaging of the human larynx is demonstrated. Though the long focal length limits the lateral resolution of the image, the basement membrane can still be readily distinguished. Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx.
authors.affiliation: University of California, Irvine, Department of Biomedical Engineering and Beckman Laser Institute, 92697, USA.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Guo
authors.forename: River
authors.initials: R
authors.lastname: Hutchison
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Jackson
authors.forename: Anu
authors.initials: A
authors.lastname: Kohli
authors.forename: Tristan
authors.initials: T
authors.lastname: Sharp
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Orwin
authors.forename: Richard
authors.initials: R
authors.lastname: Haskell
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.forename: Brian J F
authors.initials: BJ
authors.lastname: Wong
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D006801:Humans; D020704:Laryngoscopes; D008904:Miniaturization; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014827:Vocal Cords / Q000033:anatomy & histology*