title: Interactions between nonionic Triton X surfactants and cholesterol-containing phosphatidylcholine liposomes.
abstract: Solubilization kinetics experiments were developed to study the effects of the polyethylene glycol chain length of Triton X surfactants on their interactions with the cholesterol-containing phosphatidylcholine vesicles. An empirical liposome stability ratio was used to describe the vesicle solubilization process. The effectiveness of Triton X surfactants in solubilizing vesicles decreases with increasing polyethylene glycol chain length of surfactants. It was also shown that vesicles containing the intercalated surfactant molecules with the largest number of ethylene glycol units per molecule exhibited the exceedingly retarded solubilization behavior. Independent experiments based on a thermodynamic approach provide supporting evidence for the conclusions obtained from solubilization kinetics experiments.
authors.affiliation: Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
authors.forename: Chorng-Shyan
authors.initials: CS
authors.lastname: Chern
authors.forename: Hsin-Cheng
authors.initials: HC
authors.lastname: Chiu
authors.forename: Yu-Shiue
authors.initials: YS
authors.lastname: Yang
mesh_terms: D002784:Cholesterol / Q000737:chemistry*; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry*; D017830:Octoxynol / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D013997:Time Factors
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D017830:Octoxynol; D002784:Cholesterol