Glycolysis and oxidtion enzyme activity in rat brain during insulin-induced hypoglycemia against the background of alloxan-induced diabetes mellitus.
Insulin-induced hypoglycemic coma in animals with alloxan diabetes was observed at a higher basal glucose level in the blood compared to healthy animals. It was associated with inhibition of glycolysis and glycogenolysis and decreased activities of succinate dehydrogenase and glutamate dehydrogenase in the cerebral hemispheres and brainstem.
Telushkin
P K
PK
Yaroslavl State Medical Academy.
Nozdrachev
A D
AD
Potapov
P P
PP
Medvedeva
N B
NB
Stel'makh
A Yu
AY
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003926:Diabetic Coma / Q000473:pathology; D006019:Glycolysis; D007003:Hypoglycemia / Q000378:metabolism / Q000473:pathology*; D007328:Insulin / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D000496:Alloxan; D010100:Oxygen