title: [Etiologic analysis of globozoospermia: a 1-case report].
abstract: OBJECTIVE
  To investigate the etiologic factors of globozoospermia.
  
  
  METHODS
  Routine semen analysis, sperm DNA special staining and chromosomal karyotype detection of peripherical blood lymphocytes were performed in a globozoospermia patient.
  
  
  RESULTS
  Round-headed spermatozoa were lack of acrosome and the acrosin activity was low. Meanwhile, there was an additional band located in the Y chromosomal short arm.
  
  
  CONCLUSIONS
  Lack of acrosome, low acrosin activity and abnormality of chromosome may be the main reasons for globozoospermia.
authors.affiliation: Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shao
authors.forename: Yu-an
authors.initials: YA
authors.lastname: Hu
authors.forename: Ying-xia
authors.initials: YX
authors.lastname: Cui
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000176:Acrosin / Q000378:metabolism; D000328:Adult; D041322:Chromosomes, Human, Y / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D008297:Male; D012729:Sex Chromosome Aberrations; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure
chemical_list: D000176:Acrosin