title: [A case of pulmonary aspergillosis accompanied with eosinophilic pneumonia].
abstract: An infiltrative shadow was observed in the upper lobe of the left of a 60-year-old man lung during the course of paroxysmal tachycardia. Fever and coughing occurred one month later, and ground-glass opacities (GGOs) were found extensively in the lower left lung field. Although his condition strongly suggested allergic bronchopulmonary aspergillosis (ABPA) due to significantly increased eosinophil count in the peripheral blood and bronchoalveolar lavage fluid of the lower lobe of the left lung, anti-aspergillus antibody precipitation, and positive immediate intradermal test, the Rosenberg diagnostic criteria for ABPA were not satisfied. He was given a diagnosis of eosinophilic pneumonia, and GGO disappeared when itraconazole and prednisolone were administered. However, since the shadow in the upper lobe of the left lung later increased and percutaneous thoracocentesis revealed the presence of Aspergillus fumigatus, prednisolone treatment was discontinued and micafungin was administered. Nonetheless, the shadow spread into both lungs and regardless of treatment with amphotericin-B, the patient died. Although the present case is different from a typical ABPA, it indicates that allergic reaction can be induced by Aspergillus infection in the lung field, apart from the central airway. In addition, the development of an appropriate therapeutic strategy against both infection and allergy in such cases is essential.
authors.affiliation: Department of Internal Medicine, Himeji Medical Center.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Mochiduki
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakahara
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Kawamura
authors.forename: Shin
authors.initials: S
authors.lastname: Sasaki
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nishio
authors.forename: Akie
authors.initials: A
authors.lastname: Morimoto
authors.forename: Tetsuichiro
authors.initials: T
authors.lastname: Mayumi
mesh_terms: D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed