Beneficial effects of statins on perioperative cardiovascular outcome.
OBJECTIVE
This review evaluates clinical and experimental articles that have recently been published on the cardioprotective effect of perioperative statin therapy.


RESULTS
Perioperative statin therapy improves short and long-term cardiac outcome following noncardiac surgery. This cardiovascular protection has been attributed to the so-called pleiotropic effects, which have a positive effect on plaque stability. With no clinical studies reporting an increased incidence of adverse effects of perioperative statin use, it appears to be a safe and helpful therapeutic option.


CONCLUSIONS
Perioperative statin therapy may stabilize coronary plaques due to pleiotropic effects and results in a reduction of perioperative cardiovascular complications.
Dunkelgrun
Martin
M
Vascular Surgery, The Netherlands.
Schouten
Olaf
O
Feringa
Harm Hh
HH
Vidakovic
Radosav
R
Poldermans
Don
D
D050197:Atherosclerosis / Q000150:complications / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000517:prevention & control; D019990:Perioperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D016896:Treatment Outcome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors