Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC.
The purpose of these experiments is to study the effects of flavone from Cirsium japonicum DC (FLCJ) on tumor activity and on the regulation of the immune response in mice with S180 and H22 tumors. Pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone are two major components of FLCJ. FLCJ, pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone can inhibit the growth of the implanted tumors S180 and H22 and promote cellular and humoral immune responses. FLCJ is stronger than Pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone in inhibiting tumors and promoting immune response significantly. Our results indicated that the tumor inhibition of FLCJ had close relation with its regulation of the immune response Furthermore, this tumor inhibition by FLCJ may activate the innate immune system, which would be expected as a potential anti-tumor drug.
Liu
Sujun
S
Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Sciences, Sichuan University, ChengDu 610064, China.
Luo
Xun
X
Li
Daxu
D
Zhang
Jie
J
Qiu
Dunlian
D
Liu
Wei
W
She
Liang
L
Yang
Zhirong
Z
D000818:Animals; D045744:Cell Line, Tumor; D031180:Cirsium / Q000737:chemistry; D005260:Female; D047309:Flavones / Q000627:therapeutic use*; D006131:Growth Inhibitors / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use
D047309:Flavones; D006131:Growth Inhibitors; D028321:Plant Preparations