Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect.
Information on pregnancy and delivery in women with biventricular repair for isolated noncomplex pulmonary atresia with a ventricular septal defect (PAVSD) is limited. Using a nationwide congenital heart disease registry (CONgenital CORvitia [CONCOR]), 9 women with biventricular repair for PAVSD (aged 21 to 38 years) were identified. Ten pregnancies were observed in 5 different women with PAVSD, including 3 spontaneous miscarriages. Clinically significant (non)cardiac complications were documented in 3 of 7 completed pregnancies. These complications were: (1) atrioventricular reentry tachycardia with symptomatic right-sided heart failure; (2) eclampsia with hemolysis, elevated liver enzymes, and low platelets syndrome further complicated by abruptio placentae leading to premature delivery of a small-for-gestational-age child; and (3) premature delivery due to cervical insufficiency with antepartum demise of an immature child. Furthermore, none of the women reported infertility. Moreover, none of the women reported irregularities of their natural menstrual cycle (age at menarche 13 years; cycle duration 28 days), with the exception of delayed menarche (>16 years) in 2 patients. In conclusion, successful pregnancy in patients with biventricular repair of PAVSD is possible, although often complicated by serious clinically significant events. Infertility and menstrual cycle disorders do not appear to be more prevalent, except for a high incidence of primary amenorrhea.
Drenthen
Willem
W
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands. w.drenthen@thorax.umcg.nl
Pieper
Petronella G
PG
Zoon
Nicole
N
Roos-Hesselink
Jolien W
JW
Voors
Adriaan A
AA
Mulder
Barbara J M
BJ
van Dijk
Arie P J
AP
Sollie
Krystyna M
KM
Vliegen
Hubert W
HW
Ebels
Tjark
T
van Veldhuisen
Dirk J
DJ
D000328:Adult; D006348:Cardiac Surgical Procedures / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D018633:Pulmonary Atresia / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome