title: Nipple sparing subcutaneous mastectomy: sixty-six months follow-up.
abstract: OBJECTIVE
  Validation of oncological and reconstructive efficacy of nipple sparing subcutaneous mastectomy.
  
  
  METHODS
  We enrolled 50 patients on behalf of Humanitas Centro Catanese di Oncologia fulfilling appropriate reconstructive and oncological criteria to undergo nipple sparing subcutaneous mastectomy. We preferably selected women with medium size-small breast affected by early stage breast cancer peripherally located with intra-operative negative frozen section of the major ducts.
  
  
  RESULTS
  fourty-six patients were alive after a mean follow-up of 5.5 years. We observed a single case of local recurrence in the nipple successfully treated with local excision. Five patients presented metastatic disease. One is currently alive, 4 died because of progressive disease.
  
  
  CONCLUSIONS
  Our study supports other findings regarding safety and efficacy of nipple sparing subcutaneous mastectomy for selected patients.
authors.affiliation: Department of Surgical Oncology, Humanitas Centro Catanese di Oncologia, Via Dabormida 64, 95100 Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Caruso
authors.forename: M
authors.initials: M
authors.lastname: Ferrara
authors.forename: G
authors.initials: G
authors.lastname: Castiglione
authors.forename: G
authors.initials: G
authors.lastname: Trombetta
authors.forename: L
authors.initials: L
authors.lastname: De Meo
authors.forename: G
authors.initials: G
authors.lastname: Catanuto
authors.forename: G
authors.initials: G
authors.lastname: Carillio
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015414:Mastectomy, Subcutaneous; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009558:Nipples; D016019:Survival Analysis; D016896:Treatment Outcome