title: Idiopathic scoliosis: identification of candidate regions on chromosome 19p13.
abstract: METHODS
  We performed genomic screening, statistical linkage analysis, and fine mapping of 202 families with at least 2 individuals with idiopathic scoliosis.
  
  
  OBJECTIVE
  To identify regions on chromosome 19p13 statistically linked to the phenotypic expression of idiopathic scoliosis.
  
  
  BACKGROUND
  Idiopathic scoliosis is a common structural curvature of the spine affecting otherwise healthy children. Presently, no clear consensus exists regarding the underlying abnormality or genetic determinants of this disease.
  
  
  METHODS
  Model-independent linkage analysis of qualitative and quantitative traits related to scoliosis was used to screen genotyping data from 391 markers in 202 families (1198 individuals). Subsets of families with probands having a curve > or = 30 degrees were dichotomized based on the most likely mode of inheritance for each family (autosomal dominant or X-linked dominant). Fine mapping was performed to show linkage to candidate regions on chromosome 19.
  
  
  RESULTS
  When the threshold of disease was set at a curvature of > or = 30 degrees, qualitative linkage analysis revealed significant results at 2 successive markers on chromosome 19.
  
  
  CONCLUSIONS
  The data confirm a previously reported genetic locus on chromosome 19 as potentially significant in the etiology of idiopathic scoliosis.
authors.affiliation: Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Kris J
authors.initials: KJ
authors.lastname: Alden
authors.forename: Beth
authors.initials: B
authors.lastname: Marosy
authors.forename: Nneka
authors.initials: N
authors.lastname: Nzegwu
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Justice
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Wilson
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Miller
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000235:genetics*; D013131:Spine / Q000000981:diagnostic imaging
chemical_list: D005819:Genetic Markers