title: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) mimicking systemic lupus erythematosus: a review of two cases.
abstract: Kikuchi-Fujimoto's disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limited lymphadenitis commonly found in young women. It often shares clinical features with systemic lupus erythematosus (SLE), such as arthralgias, fever and leukopenia. The etiology of KFD remains unknown and controversial. Clinical course is favorable, with spontaneous remission in less than four months in almost all cases. Herein, we present two cases. The former is a 53-year old woman presenting with cervical lymphadenopathy, arthralgia, pancytopenia and positive antinuclear antibody (ANA). Lymph node biopsy revealed histopathological features compatible with Kikuchi-Fujimoto histiocytic necrotizing lymphadenitis. The latter patient was a 20-year old woman presenting with left cervical lympadenopathy, a butterfly rash that was reminiscent of SLE, and a positive antinuclear antibody. Based upon clinical, histological and laboratory findings, the diagnosis of SLE was excluded. Careful attention should be paid to differentiating between KFD and SLE, because of their similar presentations, yet different clinical courses and therapeutic requirements.
authors.affiliation: Department of Hematology, Gaziantep University, School of Medicine, Gaziantep, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yilmaz
authors.forename: C
authors.initials: C
authors.lastname: Camci
authors.forename: I
authors.initials: I
authors.lastname: Sari
authors.forename: V
authors.initials: V
authors.lastname: Okan
authors.forename: A
authors.initials: A
authors.lastname: Sevinc
authors.forename: A M
authors.initials: AM
authors.lastname: Onat
authors.forename: H
authors.initials: H
authors.lastname: Buyukhatipoglu
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology; D005148:Facial Dermatoses / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis*; D006801:Humans; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D010198:Pancytopenia / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear