Microwave-assisted synthesis of 3,1,2- and 2,1,8-Re(I) and 99mTc(I)-metallocarborane complexes.
Microwave heating was used to prepare eta5-rhenium carborane complexes in aqueous reaction media. For carboranes bearing sterically demanding substituents, isomerization of the cage from 3,1,2 to 2,1,8 derivatives occurred concomitantly with complexation. Microwave heating was equally effective at the tracer level using technetium-99m, affording access to a new class of synthons for designing novel molecular imaging agents.
Green
Andrew E C
AE
Departments of Chemistry and Medical Physics & Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1.
Causey
Patrick W
PW
Louie
Anika S
AS
Armstrong
Andrea F
AF
Harrington
Laura E
LE
Valliant
John F
JF
D002244:Carbon / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D008670:Metals / Q000737:chemistry; D008872:Microwaves; D008956:Models, Chemical; D008968:Molecular Conformation; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
D008670:Metals; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012211:Rhenium; D013667:Technetium; D002244:Carbon