title: The influence of surface bioactivated modification on titanium percutaneous implants anchored in bone.
abstract: In order to achieve biological sealing and resist mechanical damage of load-bearing percutaneous devices, Ti with excellent mechanical properties was anodic-oxidized to be endowed with bioactivity, with plasma-sprayed hydroxyapatite coated Ti as control. Similar to previous works, hydroxyapatite coating could bond tightly with living tissues, resulting in implant stability for whole implantation periods. Meanwhile, when anodic-oxidized bioactivated Ti was implanted percutaneously in vivo, it could induce a layer of calcium phosphate at the interface of tissues/implant. This layer of Ca-P not only induced the fibrous tissue or collagen ingrowth in its structure, but also improved the osteointegration between the bone and the implant. There was no significant biological response difference for the anodic-oxidized Ti and HA coated Ti at different implantation period with histological statistical analysis (p>0.05). Accordingly, suitable bioactivated modified surface of Ti by anodic-oxidized method could not only obtain the same results as the HA coating, but also might avoid some drawbacks of plasma-sprayed HA coatings to achieve biological sealing for a long period in vivo.
authors.affiliation: Engineering Research Center in Biomaterials, Sichuan University, Chengdu - China. yaowu_amanda@126.com
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: B C
authors.initials: BC
authors.lastname: Yang
authors.forename: C L
authors.initials: CL
authors.lastname: Deng
authors.forename: Y F
authors.initials: YF
authors.lastname: Tan
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003094:Collagen / Q000378:metabolism; D017886:Durapatite; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000033:anatomy & histology / Q000601:surgery; D014025:Titanium; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003094:Collagen; D017886:Durapatite; D014025:Titanium