title: Persistent organochlorine pollutants in children working at a waste-disposal site and in young females with high fish consumption in Managua, Nicaragua.
abstract: The aim of this study was to assess persistent organochlorine pollutant (POP) levels in serum collected from children (11-15 years old) working and sometimes also living at the municipal waste-disposal site in Managua, located at the shore of Lake Managua, and in nonworking children living both nearby and also far away from the waste-disposal site. The influence of fish consumption was further evaluated by assessing POPs levels in serum from young women (15-24 years old) with markedly different patterns of fish consumption from Lake Managua. 2,2-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (4,4'-DDT) and 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethene (4,4'-DDE), gamma-hexachlorocyclohexane (gamma-HCH), polychlorinated biphenyls, pentachlorophenol, and polychlorobiphenylols were quantified in all samples. In general, the levels observed were higher than those reported in children from developed countries, such as Germany and United States. Toxaphene, aldrin, dieldrin, and beta-HCH could not be identified in any sample. The children working at the waste-disposal site had higher levels of POPs compared with the nonworking reference groups. In children not working, there were also gradients for several POPs, according to vicinity to the waste-disposal site. Moreover, in children, as well as in young women, there were gradients according to fish consumption. The most abundant component was 4,4'-DDE, but at levels still lower than those reported in children from malarious areas with a history of recent or current application of 4,4'-DDT for vector control.
authors.affiliation: Faculty of Medical Sciences, National Autonomous University of Nicaragua-Managua. steven.cuadra@med.lu.se
authors.forename: Steven N
authors.initials: SN
authors.lastname: Cuadra
authors.forename: Linda
authors.initials: L
authors.lastname: Linderholm
authors.forename: Maria
authors.initials: M
authors.lastname: Athanasiadou
authors.forename: Kristina
authors.initials: K
authors.lastname: Jakobsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D005399:Fishes; D020387:Food Chain; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage / Q000032:analysis*; D008297:Male; D009527:Nicaragua; D016273:Occupational Exposure; D012989:Soil Pollutants / Q000008:administration & dosage / Q000032:analysis*; D014866:Waste Products; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000032:analysis*
chemical_list: D006843:Hydrocarbons, Chlorinated; D012989:Soil Pollutants; D014866:Waste Products; D014874:Water Pollutants, Chemical