title: Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate.
abstract: This study was designed to determine the effect of ornithine alpha-ketoisocaproate (O-KIC), a compound reducing muscle protein breakdown in physiological conditions, on liver factors involved in drug metabolism in rats with acute retrograde pyelonephritis. 91 rats were assigned to 7 groups differing in the level of food intake, induced infection, and the treatment by O-KIC (168 mg/kg bw/day). Rats were killed on the third day. O-KIC increased nitrogen balance and weight gain in controls, but not in malnourished infected or non-infected rats. Liver glutathione was significantly reduced by O-KIC in malnourished infected and non-infected rats. Though O-KIC induced a rise in liver microsomal proteins in control and infected animals, it decreased cytochrome P-450 in controls, and aminopyrine demethylase in both control and infected groups.
authors.affiliation: Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle Hôpital Charles Nicolle, 76031 Rouen-Cédex, France.
authors.forename: J
authors.initials: J
authors.lastname: Petit
authors.forename: H
authors.initials: H
authors.lastname: Fouin-Fortunet
authors.forename: V
authors.initials: V
authors.lastname: Colomb
authors.forename: B
authors.initials: B
authors.lastname: Hecketsweiler
authors.forename: J F
authors.initials: JF
authors.lastname: Lemeland
authors.forename: P
authors.initials: P
authors.lastname: Denis
authors.forename: R
authors.initials: R
authors.lastname: Colin