A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
Bach
Peter
P
Department of Medicinal Chemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, S-431 83 Mölndal, Sweden. Peter.Bach@astrazeneca.com
Nilsson
Karolina
K
Wållberg
Andreas
A
Bauer
Udo
U
Hammerland
Lance G
LG
Peterson
Alecia
A
Svensson
Tor
T
Osterlund
Krister
K
Karis
David
D
Boije
Maria
M
Wensbo
David
D
D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000480:Alkynes; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C023666:pyridine