Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein.
The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein--a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.
Olejnik-Schmidt
Agnieszka K
AK
Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Poznań, Poland. mschmidt@au.poznan.pl
Schmidt
Marcin T
MT
Goździcka-Józefiak
Anna
A
D000818:Animals; D019556:COS Cells; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D052162:Human papillomavirus 16 / Q000235:genetics; D006801:Humans; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D009856:Oncogene Proteins, Viral / Q000378:metabolism* / Q000502:physiology; D030361:Papillomavirus Infections / Q000235:genetics / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism* / Q000502:physiology; D012441:Saccharomyces cerevisiae; D014162:Transfection; D020798:Two-Hybrid System Techniques; D014779:Virus Replication / Q000235:genetics
D004268:DNA-Binding Proteins; C054855:E2 protein, Human papillomavirus type 16; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D009856:Oncogene Proteins, Viral; D011987:Receptors, Steroid