title: [Management of patients with non-functioning gastroentero-pancreatic neuroendocrine tumours].
abstract: The Authors examine the feasibility of diagnosing non-functioning gastroentero-pancreatic neuroendocrine tumours preoperatively or intraoperatively, with particular reference to laboratory examinations and octreoscan scintigraphy, which are capable of conditioning the surgical treatment and subsequent follow-up. Of the 4 cases reported here: three presented multiple intestinal localizations, and in only one case the origin of the primitive carcinoma was undefined. The suspicion of a non-functioning neuroendocrine tumour must be considered when yellowish or ochre-coloured intestinal lesions are found intraoperatively. Determination of specific markers and octreoscan scintigraphy must be performed without awaiting histological confirmation. Surgery plays a fundamental role in the debulking of these carcinomas. However, medical therapy with the aid of specific laboratory examinations and octreoscan scintigraphy may improve the long-term survival.
authors.affiliation: AOU Senese UOC Chirurgia 2 - Siena.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Guarnieri
authors.forename: Andrea
authors.initials: A
authors.lastname: Tirone
authors.forename: Eleonora
authors.initials: E
authors.lastname: Pallucca
authors.forename: Michele
authors.initials: M
authors.lastname: Testa
authors.forename: Alessandro
authors.initials: A
authors.lastname: Piccolomini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vuolo
authors.forename: Vinno
authors.initials: V
authors.lastname: Savelli
authors.forename: Leonardo
authors.initials: L
authors.lastname: Di Cosmo
authors.forename: Luigi
authors.initials: L
authors.lastname: Verre
authors.forename: Anton Ferdinando
authors.initials: AF
authors.lastname: Carli
mesh_terms: D000368:Aged; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000601:surgery*