Retinoids in clinical use.
Retinoids have been investigated for their therapeutic potential for the past 3 decades. They have a reputation for being both beneficial in the treatment of several diseases and detrimental due to toxic and/or teratogenic side effects. The purpose of this review is to highlight retinoids that are currently used in the clinic. We also discuss their mechanisms of action and research strategies to develop new and safer retinoid-based therapies.
Njar
Vincent C O
VC
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 2101-1559, USA. vnjar001@umaryland.edu
Gediya
Lalji
L
Purushottamachar
Puranik
P
Chopra
Pankaj
P
Belosay
Aashvini
A
Patel
Jyoti B
JB
D002986:Clinical Trials as Topic; D006801:Humans; D015394:Molecular Structure; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D012176:Retinoids