title: Numerical simulation of corneal transport processes.
abstract: This paper presents a numerical study on the transport of ions and ionic solution in human corneas and the corresponding influences on corneal hydration. The transport equations for each ionic species and ionic solution within the corneal stroma are derived based on the transport processes developed for electrolytic solutions, whereas the transport across epithelial and endothelial membranes is modelled by using phenomenological equations derived from the thermodynamics of irreversible processes. Numerical examples are provided for both human and rabbit corneas, from which some important features are highlighted.
authors.affiliation: School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK. l.y.li@aston.ac.uk
authors.forename: Long-yuan
authors.initials: LY
authors.lastname: Li
authors.forename: Brian
authors.initials: B
authors.lastname: Tighe
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D003198:Computer Simulation; D003315:Cornea / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009994:Osmolar Concentration; D011817:Rabbits; D013816:Thermodynamics