Evaluation of interleukin 13 polymorphisms in systemic sclerosis.
Systemic sclerosis (SSc) is a multisystem disease of unknown etiology. It is characterized by excessive cutaneous and visceral fibrosis, damage to small blood vessels, and production of autoantibodies. Interleukin-13 (IL-13) has been shown to be involved in abnormal fibrosis in other diseases. Therefore, we have evaluated its possible involvement in SSc. We analyzed four IL13 gene polymorphisms, rs1800925 (IL13-1055), rs20541 (Arg130Gln), rs847, and rs2243204 in 107 unrelated SSc patients (40 patients having diffuse cutaneous form and 67 patients having limited cutaneous form) and in 170 controls. All subjects were Caucasians. In the total patient population and in the diffuse cutaneous subset, we observed an association between two IL13 polymorphisms, IL13 rs1800925 (IL13-1055), and IL13 rs2243204, and disease (p=0.03-0.04). The IL13 rs2243204T allele was more common in SSc patients (p=0.01, OR=2.3 CI 1.21-4.38) and in the diffuse cutaneous form (p=0.01, OR=2.95, CI 1.35-6.49) than in control subjects. Our result supports the suggestion that polymorphisms in IL13 are associated to SSc and skin fibrosis process. However, further studies on larger and independent population and functional analyses are needed to confirm these findings.
Granel
Brigitte
B
Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, UMR 399 INSERM, Université de la Méditerranée, Faculté de Médecine, 13005, Marseille, France. brigitte.granel@medecine.univ-mrs.fr
Chevillard
Christophe
C
Allanore
Yannick
Y
Arnaud
Violaine
V
Cabantous
Sandrine
S
Marquet
Sandrine
S
Weiller
Pierre-Jean
PJ
Durand
Jean-Marc
JM
Harlé
Jean-Robert
JR
Grange
Claire
C
Frances
Yves
Y
Berbis
Philippe
P
Gaudart
Jean
J
de Micco
Philippe
P
Kahan
André
A
Dessein
Alain
A
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005355:Fibrosis; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000097:blood / Q000235:genetics*; D012867:Skin / Q000473:pathology
D018793:Interleukin-13