Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1.
Functional activity of macrophages and intensity of T cell immune response in mice were studied after intravaginal and intraperitoneal infection with herpes simplex virus type 1 and DNA vaccination in combination with adjuvant treatment (recombinant granulocyte-macrophage colony-stimulating factor and glucosaminylmuramyl dipeptide). DNA vaccination induced a virus-specific T cell immune response with no macrophagic inflammatory reaction. Infection with herpes simplex virus type 1 was accompanied by sustained inflammation, but not by the T cell immune response.
Nagurskaya
E V
EV
N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Zaitseva
L G
LG
Kobets
N V
NV
Kireeva
I V
IV
Bekhalo
V A
VA
Kozlov
A Yu
AY
Klimova
R R
RR
Gur'yanova
S V
SV
Andronova
T M
TM
Shingarova
L N
LN
Boldyreva
E F
EF
Nekrasova
O V
OV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D002465:Cell Movement; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006561:Herpes Simplex / Q000097:blood*; D018259:Herpesvirus 1, Human / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019444:Vaccines, DNA / Q000378:metabolism / Q000494:pharmacology*
D019444:Vaccines, DNA; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor