Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors.
Rhodium(II) propionate, [Rh2(prop)4], and its adduct with nicotinate (nic-) and isonicotinate (isonic-) anions, [Rh2(prop)4(nic)2](2-) and [Rh2(prop)4(isonic)2](2-), respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were tested and presented in the form of a survival table, and analyzed by the Mantel-Haenszel chi-square test for N animals in each group. The survival rates of animals were significantly higher than that of control group (P<0.001) without distinguishing among the experimental groups. The estimated probability for an animal in the control group to survive up to the end of the observation period (30 days) was below 33%, whereas the animal groups in the treated group with complex, and its nicotinate and isonicotinate groups showed 85%, 85% and 90%, respectively, of surviving over the same period. The T/C values (survival average of the animals treated group/survival average of the animals control group) were obtained for each compounds being for the dirhodium propionate T/C=250, and for its adducts with nicotinate and isonicotinate anions, 267 and 264, respectively.
de Souza
Aparecido Ribeiro
AR
Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, CP 131, 74001-970 Goiânia, GO, Brazil. ardsouza@quimica.ufg.br
Coelho
Eliel Pereira
EP
Zyngier
Szulim Ber
SB
D000818:Animals; D000838:Anions / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007539:Isonicotinic Acids / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D009525:Niacin / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D015996:Survival Rate; D023041:Xenograft Model Antitumor Assays
D000838:Anions; D000970:Antineoplastic Agents; D007539:Isonicotinic Acids; D009942:Organometallic Compounds; D011422:Propionates; D009525:Niacin; D012238:Rhodium