title: Effect of cardiac motion on body surface electrocardiographic potentials: an MRI-based simulation study.
abstract: This paper describes an electrical model of cardiac ventricles incorporating real geometry and motion. The heart anatomy and its motion through the cardiac cycle are obtained from segmentations of multiple-slice MRI time sequences; the special conduction system is constructed using an automated mapping procedure from an existing static heart model. The heart model is mounted in an anatomically realistic voxel model of the human body. The cardiac electrical source and surface potentials are determined numerically using both a finite-difference scheme and a boundary-element method with the incorporation of the motion of the heart. The electrocardiograms (ECG) and body surface potential maps are calculated and compared to the static simulation in the resting heart. The simulations demonstrate that introducing motion into the cardiac model modifies the ECG signals, with the most obvious change occurring during the T-wave at peak contraction of the ventricles. Body surface potential maps differ in some local positions during the T-wave, which may be of importance to a number of cardiac models, including those incorporating inverse methods.
authors.affiliation: School of Information Technology and Electrical Engineering, University of Queensland, Qld, Australia.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Ben
authors.initials: B
authors.lastname: Appleton
authors.forename: Ling
authors.initials: L
authors.lastname: Xia
authors.forename: Nianjun
authors.initials: N
authors.lastname: Liu
authors.forename: Stephen
authors.initials: S
authors.lastname: Wilson
authors.forename: Robyn
authors.initials: R
authors.lastname: Riley
authors.forename: Wendy
authors.initials: W
authors.lastname: Strugnel
authors.forename: Richard
authors.initials: R
authors.lastname: Slaughter
authors.forename: Russel
authors.initials: R
authors.lastname: Denman
authors.forename: Stuart
authors.initials: S
authors.lastname: Crozier
mesh_terms: D000465:Algorithms; D018780:Body Surface Potential Mapping / Q000379:methods*; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015233:Models, Statistical; D009068:Movement; D009206:Myocardium / Q000473:pathology*