title: Synthesis and cardiac effects of 3,4-dihydropyrimidin-2(1H)-one-5 carboxylates.
abstract: A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.
authors.affiliation: Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (DU), Porur, Chennai 600 116, India.
authors.forename: Kuppusamy
authors.initials: K
authors.lastname: Sujatha
authors.forename: Pachaiyappan
authors.initials: P
authors.lastname: Shanmugam
authors.forename: Paramasivam T
authors.initials: PT
authors.lastname: Perumal
authors.forename: Doraisamy
authors.initials: D
authors.lastname: Muralidharan
authors.forename: Melani
authors.initials: M
authors.lastname: Rajendran
mesh_terms: D000818:Animals; D001001:Anura; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D011743:Pyrimidines; D006859:Hydrogen; C030986:pyrimidine