The effect of luteolin-7-O-beta-D-glucuronopyranoside on gastritis and esophagitis in rats.
This study evaluated the inhibitory action of luteolin-7-O-beta-D-glucuronopyranoside, luteolin which was isolated from Salix gilgiana leaves, and omeprazole on reflux esophagitis and gastritis in rats. Reflux esophagitis and gastritis were induced surgically and by the administration of indomethacin, respectively. The intraduodenal administration of luteolin-7-O-beta-D-glucuronopyranoside decreased the ulcer index, injury area, gastric volume and acid output, and increased the gastric pH compared with luteolin. Luteolin-7-O-beta-D-glucuronopyranoside significantly decreased the size of the gastric lesions that had been induced by exposing the gastric mucosa to indomethacin. The malondialdehyde content, which is the end product of lipid peroxidation, was increased significantly after inducing of reflux esophagitis. The malondialdehyde content was decreased by Luteolin-7-O-beta-D-glucuronopyranoside but not luteolin or omeprazole. Luteolin-7-O-beta-D-glucuronopyranoside has a more potent antioxidative effect than luteolin. Luteolin-7-O-beta-D-glucuronopyranoside is a promising drug for the treatment of reflux esophagitis and gastritis.
Min
Young Sil
YS
Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul, Korea.
Bai
Ki Lyong
KL
Yim
Sung Hyuk
SH
Lee
Young Joo
YJ
Song
Hyun Ju
HJ
Kim
Jin Hak
JH
Ham
Inhye
I
Whang
Wan Kyun
WK
Sohn
Uy Dong
UD
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004942:Esophagitis, Peptic / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005756:Gastritis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D007213:Indomethacin; D015227:Lipid Peroxidation; D047311:Luteolin / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009853:Omeprazole / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D032108:Salix / Q000737:chemistry*
D000975:Antioxidants; D005960:Glucosides; D008315:Malondialdehyde; C066408:luteolin-7-glucoside; D009853:Omeprazole; D047311:Luteolin; D007213:Indomethacin