Uridine supplementation enhances hepatic mitochondrial function in thymidine-analogue treated HIV-infected patients.
Supplementation with uridine offers the possibility of a new and promising approach to nucleoside analogue reverse transcriptase inhibitor-associated mitochondrial toxicity. We investigated the metabolic effects of short-course treatment with the uridine-enriched food supplement NucleomaxX on hepatic mitochondrial function in thymidine-analogue treated HIV-infected patients. Mitochondrial function was assessed by a recently introduced non-invasive C-methionine breath test. NucleomaxX supplementation enhanced mitochondrial decarboxylation function reversibly but reproducibly in all patients. Repeated administration in shorter treatment intervals may maintain this effect.
Banasch
Matthias
M
Department of Internal Medicine, St. Josef-Hospital, University of Bochum, Germany. mbanasch@gmx.de
Goetze
Oliver
O
Knyhala
Kathy
K
Potthoff
Anja
A
Schlottmann
Renate
R
Kwiatek
Monika A
MA
Bulut
Kerem
K
Schmitz
Frank
F
Schmidt
Wolfgang E
WE
Brockmeyer
Norbert H
NH
D019380:Anti-HIV Agents / Q000009:adverse effects*; D001944:Breath Tests / Q000379:methods; D019587:Dietary Supplements; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D014529:Uridine / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D014529:Uridine