title: Association studies between the plasmin genes and late-onset Alzheimer's disease.
abstract: The plasmin system is involved in the degradation of Abeta peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD). In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system. Among the four polymorphisms in the PLAT, PAI-1 and PLI genes showing nominally significant evidence for an association with AD (allele p-value=0.01-0.00003) the strongest association was detected for the deletion allele in the Alu-repeat region of the PLAT gene. However, none of these positive results were confirmed in follow-up studies using an independent Canadian case-control cohort and two familial AD datasets of North European and Caribbean Hispanic origin. Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD.
authors.affiliation: Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada.
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kawarai
authors.forename: Yan
authors.initials: Y
authors.lastname: Meng
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Lee
authors.forename: Hye-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Wakutani
authors.forename: Eri
authors.initials: E
authors.lastname: Shibata
authors.forename: Nazia
authors.initials: N
authors.lastname: Pathan
authors.forename: Andrew
authors.initials: A
authors.lastname: Bi
authors.forename: Christine
authors.initials: C
authors.lastname: Sato
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Amalia C
authors.initials: AC
authors.lastname: Bruni
authors.forename: Ranjan
authors.initials: R
authors.lastname: Duara
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.forename: Peter St
authors.initials: PS
authors.lastname: George-Hyslop
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Rogaeva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D005192:Family Health; D005260:Female; D005341:Fibrinolysin / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D053829:Amyloid Precursor Protein Secretases; D005341:Fibrinolysin