title: Intra-familial transmission of Helicobacter pylori infection in children of households with multiple generations in Vietnam.
abstract: This community-based cross-sectional study in 533 participants from 135 households with multiple generations living in the same household aimed at investigating the relationship between Helicobacter pylori infection in children and the other household members. H. pylori infection in children was found significantly associated with the infection in mothers [OR (95% CI): 2.50 (1.19-5.26)], even after being adjusted for sex, age group and sibling number [adjusted OR (95% CI): 2.47 (1.12-5.47)]. It was also significantly associated with the infection in both parents [adjusted OR (95% CI): 4.14 (1.29-13.23)]. No significant association between H. pylori infection in the father, grandparent(s), uncle or aunt with that in their children was found. Results from the present study showed intra-familial transmission in a multi-generation population and supported the hypothesis of person-to-person transmission of H. pylori infection.
authors.affiliation: Hanoi Medical University, Hanoi, Vietnam. hongbang52@yahoo.com
authors.forename: Van Bang
authors.initials: VB
authors.lastname: Nguyen
authors.forename: Gia Khanh
authors.initials: GK
authors.lastname: Nguyen
authors.forename: Dac Cam
authors.initials: DC
authors.lastname: Phung
authors.forename: Karen
authors.initials: K
authors.lastname: Okrainec
authors.forename: Josette
authors.initials: J
authors.lastname: Raymond
authors.forename: Christophe
authors.initials: C
authors.lastname: Dupond
authors.forename: Odile
authors.initials: O
authors.lastname: Kremp
authors.forename: Nicolas
authors.initials: N
authors.lastname: Kalach
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Vidal-Trecan
mesh_terms: D000293:Adolescent; D002648:Child; D005191:Family Characteristics; D005260:Female; D016481:Helicobacter Infections / Q000635:transmission*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012044:Regression Analysis; D014744:Vietnam