Sublingual vs. vaginal misoprostol for induction of labor.
OBJECTIVE
To compare sublingual with vaginal misoprostol for the induction of labor.


METHODS
This double-blind clinical trial randomized 150 women to receive every 6 h 25 mug of sublingual misoprostol and vaginal placebo or 25 mug of vaginal misoprostol and sublingual placebo. Maternal and neonatal outcomes were analyzed and risk ratios (RRs) with 95% confidence intervals (CIs) calculated. The significance level was 5%.


RESULTS
Vaginal delivery rates were 57% in the sublingual group and 69% in the vaginal group (RR, 0.8; 95% CI, 0.6-1.1). There were 11 cases of fetal distress in the sublingual group and 4 cases in the vaginal group (RR, 2.7; 95% CI, 0.9-8.2). There were no significant differences in the number of doses needed, interval between first dose and delivery, incidence of contractility disturbances, or neonatal results.


CONCLUSIONS
The administration of misoprostol 25 mug by the sublingual route was neither more effective nor safer than the same dose administered vaginally.
Feitosa
F E L
FE
Maternidade-Escola, Universidade Federal do Ceará, Fortaleza, State of Ceará, Brazil. edsonlucena@secrel.com.br
Sampaio
Z S
ZS
Alencar
C A
CA
Amorim
M M R
MM
Passini
R
R
D000282:Administration, Intravaginal; D000286:Administration, Sublingual; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D018570:Risk Assessment
D010120:Oxytocics; D016595:Misoprostol