Bilateral optic neuropathy associated with multiple myeloma.
A 51-year-old man had reduced vision and bilateral optic disc swelling as the initial clinical manifestation of multiple myeloma. Brain imaging failed to disclose any abnormalities. Before any therapy was begun, visual function began to improve substantially. Three months after chemotherapy was started, visual function and optic disc appearance returned to near normal. There were no features to suggest polyneuropathy-organomegaly-endocrinopathy-M protein-skin changes (POEMS) syndrome. Visual loss in myeloma is usually caused by compression or infiltration of the optic nerves by tumor. The mechanism of the optic neuropathy in this case remains unknown.
Shimada
Yoshiaki
Y
Department of Ophthalmology, Saitama Medical School, Iruma, Saitama, Japan. ysmd@za2.so-net.ne.jp
Shibuya
Masayuki
M
Ohki
Ryutaro
R
Yoneya
Shin
S
Nakamura
Yuichi
Y
D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields