title: Deep-probe metal-clad waveguide biosensors.
abstract: Two types of metal-clad waveguide biosensors, so-called dip-type and peak-type, are analyzed and tested. Their performances are benchmarked against the well-known surface-plasmon resonance biosensor, showing improved probe characteristics for adlayer thicknesses above 150-200 nm. The dip-type metal-clad waveguide sensor is shown to be the best all-round alternative to the surface-plasmon resonance biosensor. Both metal-clad waveguides are tested experimentally for cell detection, showing a detection limit of 8-9 cells/mm2.
authors.affiliation: Risø National Laboratory, Optics and Plasma Research Department, DK-4000 Roskilde, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Skivesen
authors.forename: R
authors.initials: R
authors.lastname: Horvath
authors.forename: S
authors.initials: S
authors.lastname: Thinggaard
authors.forename: N B
authors.initials: NB
authors.lastname: Larsen
authors.forename: H C
authors.initials: HC
authors.lastname: Pedersen
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D012031:Refractometry / Q000295:instrumentation*; D020349:Surface Plasmon Resonance / Q000295:instrumentation