title: Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer.
abstract: Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p<0.05). This was especially evident in CRC antecedents and nuclear forms of CRC. If both CG (eNOS) and TiA (CAV1) haplotypes were taken together, this association increased in significance. Thus, we propose that CAV1, either alone or together with eNOS alleles, might modify CRC heritability.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
authors.forename: Manuel Chaves
authors.initials: MC
authors.lastname: Conde
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramirez-Lorca
authors.forename: Jose Miguel Esteban
authors.initials: JM
authors.lastname: Lopez-Jamar
authors.forename: Eva
authors.initials: E
authors.lastname: Molero
authors.forename: Juan Andres
authors.initials: JA
authors.lastname: Ramírez-Armengol
authors.forename: Jose Andrés
authors.initials: JA
authors.lastname: Moreno Nogueira
authors.forename: Manuel Hidalgo
authors.initials: MH
authors.lastname: Pascual
authors.forename: Agustin
authors.initials: A
authors.lastname: Ruiz
authors.forename: Carlos García
authors.initials: CG
authors.lastname: Martín-Cordova
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Real
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Royo
mesh_terms: D000368:Aged; D000483:Alleles; D051242:Caveolin 1 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D051242:Caveolin 1; D052250:Nitric Oxide Synthase Type III