[Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model].
OBJECTIVE
To investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model at different stages of inflammation of varied severity.


METHODS
The periodontal tissues were immunohistochemically stained by antibody of MMP-2 and MMP-3.


RESULTS
MMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodontitis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis.


CONCLUSIONS
The expression of MMP-2 and MMP-3 varies in different stage of periodontitis. MMP-2 and MMP-3 may play an important role in development of periodontitis.
Zhao
Xiao-Qin
XQ
Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China.
Meng
Shu
S
Wu
Ya-Fei
YF
Chen
Yu
Y
Ge
Song
S
D000818:Animals; D055113:Chronic Periodontitis; D005347:Fibroblasts; D005891:Gingivitis; D008297:Male; D020778:Matrix Metalloproteinase 2; D010513:Periodontal Ligament; D010518:Periodontitis; D051381:Rats
D020778:Matrix Metalloproteinase 2