title: Effects of salbutamol and glyceryl trinitrate on large arterial stiffness are similar between patients with hypertension and adults with normal blood pressure.
abstract: OBJECTIVE
  Endothelial function is characteristically impaired in patients with hypertension. Endothelial function was assessed in men and women with hypertension using a recently described, non-invasive method.
  
  
  METHODS
  Twenty patients and 20 controls received salbutamol 400 microg and glyceryl trinitrate (GTN) 500 microg in a two-way randomized, single-blind study. Effects on augmentation index (AIx) were assessed using pulse wave analysis (PWA).
  
  
  RESULTS
  Responses (absolute AIx reduction and 95% confidence interval) to salbutamol were 8.4% (6.2, 10.6) and 8.3% (7.0, 9.6) in patients and controls, respectively, and those to GTN were 13.6% (10.8, 16.4) and 15.5% (13.0, 17.0), respectively.
  
  
  CONCLUSIONS
  Systemic arterial responses to endothelium-dependent and -independent vasodilators are preserved in patients with mild, uncomplicated hypertension, indicating normal large arterial endothelial function.
authors.affiliation: Clinical Pharmacology Unit, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK. s.waring@ed.ac.uk
authors.forename: W Stephen
authors.initials: WS
authors.lastname: Waring
authors.forename: Hannah M
authors.initials: HM
authors.lastname: Sinclair
authors.forename: David J
authors.initials: DJ
authors.lastname: Webb
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000328:Adult; D000420:Albuterol / Q000627:therapeutic use*; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000318:Adrenergic beta-Agonists; D014665:Vasodilator Agents; D005996:Nitroglycerin; D000420:Albuterol