title: Small intestinal lactase status, frequency distribution of enzyme activity and milk intake in a multi-ethnic population.
abstract: The aims of the study were to investigate the prevalence of primary lactase deficiency, frequency distribution of lactase activity and the relationship between lactose intake and lactase activity in three ethnic groups resident in Birmingham. Seventy-two white, 103 Indian and 58 Afro-Caribbean adult dyspeptic patients had distal duodenal biopsies taken for disaccharidase assay at endoscopy. Ten percent of whites, 51% Indians and 81% Afro-Caribbeans had primary lactase deficiency (sucrase/lactase ratio > 4). There was a generalized unexplained depression of disaccharidase activities in the Indians. Frequency distribution of lactase activity for the whole population showed a negative skew without evidence of trimodality. Lactose intake and symptoms attributed to lactose were assessed in a subgroup of 20 whites, 20 Indians and 18 Afro-Caribbeans by questionnaire. Lactose intake did not differ between lactase persistent and deficient subjects both within each racial group and between the groups. Diarrhoea, bloating and cramps were not significantly more common in lactase deficient than lactase persistent individuals.
authors.affiliation: Gastroenterology Unit, City Hospital, Dudley Road, Birmingham B18 7QH, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Iqbal
authors.forename: R
authors.initials: R
authors.lastname: Bradley
authors.forename: H M
authors.initials: HM
authors.lastname: Reilly
authors.forename: K O
authors.initials: KO
authors.lastname: Lewis
authors.forename: B T
authors.initials: BT
authors.lastname: Cooper