title: Clinical outcome of 36 male patients with primary urethral carcinoma: a single center experience.
abstract: OBJECTIVE
  Retrospective analysis of male urethral carcinoma to assess the best therapeutic approach to the management of this tumor.
  
  
  METHODS
  A review of 36 cases of male urethral carcinoma diagnosed and treated at our center was performed. Clinical features, treatment modality and outcomes were analysed.
  
  
  RESULTS
  The overall median survival time was 55.16 months. The 5-year overall and disease-free survival rate for the cohort was 49% and 23%, respectively. The 5-year survival is 67% for low-stage versus 33% for high-stage tumors and is significantly different (P = 0.001). The survival was 72% for tumors of the distal urethra versus 36% for tumors of the proximal, with a P-value of 0.02.
  
  
  CONCLUSIONS
  The tumor location and clinicopathological stage were the most important predictors of the disease-free and overall survival. Multimodal approach is necessary for achieving local control especially for proximal and higher stage tumors.
authors.affiliation: Department of Urologic Oncology, Tata Memorial Hospital, Mumbai, India. tbyraja@rediffmail.com
authors.forename: Yuvaraja B
authors.initials: YB
authors.lastname: Thyavihally
authors.forename: Hemant B
authors.initials: HB
authors.lastname: Tongaonkar
authors.forename: Shyam K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: Umesh
authors.initials: U
authors.lastname: Mahantshetty
authors.forename: Prabhash
authors.initials: P
authors.lastname: Kumar
authors.forename: Srinivas G
authors.initials: SG
authors.lastname: Raibhattanavar
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000401:mortality* / Q000628:therapy; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D014523:Urethral Neoplasms / Q000401:mortality* / Q000628:therapy