title: [Long QT syndrome--genes, mechanisms and risks. Indication for genetic family screening?].
abstract: Inherited long QT syndrome (LQTS) is a cardiac disease characterised by episodes of ventricular tachyarrhythmia, presenting as syncope or sudden death. Untreated, the annual mortality rate is 1-2%. Sudden death has been reported as the first manifestation of the disease in some cases. Therefore, early (pre-symptomatic) diagnosis and management may save lives. However, clinically false negative relatives are also at risk of sudden death. On this basis we conclude assessment of relatives should be extended with genetic testing.
authors.affiliation: H:S Rigshospitalet, Hjertecentret, Statens Serum Institut, Klinisk Biokemisk Afdeling, og Arhus Universitetshospital, Skejby Sygehus, Hjertemedicinsk Afdeling. henningbundgaard@dadlnet.dk
authors.forename: Henning
authors.initials: H
authors.lastname: Bundgaard
authors.forename: Ole
authors.initials: O
authors.lastname: Havndrup
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.forename: Paal Skytt
authors.initials: PS
authors.lastname: Andersen
authors.forename: Henrik Kjaerulff
authors.initials: HK
authors.lastname: Jensen
authors.forename: Jesper Hastrup
authors.initials: JH
authors.lastname: Svendsen
authors.forename: Keld P
authors.initials: KP
authors.lastname: Kjeldsen
mesh_terms: D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008133:Long QT Syndrome / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D012307:Risk Factors; D013575:Syncope / Q000175:diagnosis / Q000235:genetics
chemical_list: D007473:Ion Channels