Lung transplantation in patients with cystic fibrosis: the Israeli experience.
BACKGROUND
Lung transplantation is a well-established therapeutic option for end-stage lung disease in cystic fibrosis. Although it confers a clear survival advantage, outcome differs among centers according to local experience, patient selection, transplantation procedure, and postoperative care.


OBJECTIVE
To evaluate the national Israeli experience with lung transplantation in patients with CF.


METHODS
We reviewed the medical charts of all CF patients who underwent lung transplantation between January 1996 and June 2005 at the two Israeli centers that perform this procedure.


RESULTS
Eighteen transplantations were performed in 17 patients. Mean patient age at transplantation was 25.3 +/- 9.1 years, and mean duration of follow-up in survivors (n=14) was 37.2 months (range 1-113 months). The actuarial survival rate was 88% at 1 year and 74% at 5 years. Pulmonary function, expressed as percent of predicted normal forced expiratory volume in 1 sec, improved from 22.4 +/- 8.1% to 76 +/- 16.8% at one year after transplantation. Bronchiolitis obliterans syndrome was diagnosed in 5 patients (29%), of whom 2 died and 2 are currently candidates for retransplantation. Median time to onset of BOS was 34.2 months (range 17-64 months).


CONCLUSIONS
In Israel, the early and intermediate-term results of lung transplantation for cystic fibrosis are encouraging. BOS remains a major complication that threatens long-term outcome.
Prais
Dario
D
Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel.
Raviv
Yael
Y
Shitrit
David
D
Yellin
Alon
A
Sahar
Gideon
G
Bendayan
Danielle
D
Yahav
Yaacov
Y
Efrati
Ori
O
Reichart
Nira
N
Blau
Hannah
H
Bakal
Ilana
I
Buchman
Gila
G
Saute
Milton
M
Vidne
Bernardo
B
Kramer
Mordechai R
MR
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D001989:Bronchiolitis Obliterans / Q000209:etiology; D003550:Cystic Fibrosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007557:Israel; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008499:Medical Records; D012189:Retrospective Studies; D016019:Survival Analysis