New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones.
A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.
Waisser
K
K
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia. waisser@faf.cuni.cz
Heinisch
L
L
Slosárek
M
M
Janota
J
J
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects; D019907:Mycobacterium fortuitum / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D013871:Thiones / Q000737:chemistry / Q000494:pharmacology*
C514356:2,3-dihydro-1-butyl-2-thioxoindole-3-one; C514355:2,3-dihydro-1-methyl-2-thioxoindole-3-one; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D007211:Indoles; D013871:Thiones; D007538:Isoniazid