[Lymphomatoid granulomatosis after treatment of an acute myeloid leukemia].
We report a case of lymphomatoid granulomatosis (LG), arising in a 60-year-old man in the setting of an acute myeloid leukemia. LG is a rare Epstein Barr virus (EBV) lymphoproliferative disorder, generally occurring in a context of immunodeficiency. Patients usually present with respiratory symptoms and bilateral pulmonary nodules. Histologically LG is characterized by an angiocientric and angiodestructive lymphoproliferation of B/EBV+ cells admixed with numerous reactive T cells. The differential diagnosis mainly includes pulmonary vasculitis and Hodgkin's lymphoma. The outcome of this lymphoproliferation is highly variable, ranging from an indolent process to an aggressive large cell lymphoma.
Ragage
Florence
F
Département de Pathologie, Hôpital du Haut-lévêque, CHU Bordeaux, Avenue de Magellan, 33604 Pessac, France.
Parrens
Marie
M
Banos
Anne
A
Renoux
Michel
M
Bégueret
Hugues
H
Merlio
Jean-Philippe
JP
de Mascarel
Antoine
A
D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000473:pathology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D015703:Antigens, CD; D019309:Epstein-Barr Virus Nuclear Antigens