title: Short report: immune response and occurrence of dengue infection in thai children three to eight years after vaccination with live attenuated tetravalent dengue vaccine.
abstract: From 1992 to 1997, 140 Thai children 4-15 years of age received an investigational live attenuated tetravalent dengue vaccine (LATDV). These children were contacted 3-8 years later in 2001 to assess humoral immunity and investigate whether they were subsequently at higher risk of developing severe dengue. One hundred thirteen were successfully contacted and participated in this retrospective cohort study with two age- and address-matched controls per vaccinee. The number of vaccinated subjects with neutralizing antibodies increased compared with 3-8 years earlier, which was probably due to subsequent wild-type dengue infections. There were no excess hospitalizations for clinically suspected dengue fever (DF) or dengue hemorrhagic fever (DHF) in vaccinees (one with DF and three with DHF) compared with controls (14 with DHF). Results suggest that preexisting dengue antibodies induced by LATDV do not enhance dengue illness, and the use of the vaccine in a dengue-endemic area is safe.
authors.affiliation: Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Pornthep
authors.initials: P
authors.lastname: Chanthavanich
authors.forename: Christine
authors.initials: C
authors.lastname: Luxemburger
authors.forename: Chukiat
authors.initials: C
authors.lastname: Sirivichayakul
authors.forename: Keswadee
authors.initials: K
authors.lastname: Lapphra
authors.forename: Krisana
authors.initials: K
authors.lastname: Pengsaa
authors.forename: Sutee
authors.initials: S
authors.lastname: Yoksan
authors.forename: Arunee
authors.initials: A
authors.lastname: Sabchareon
authors.forename: Jean
authors.initials: J
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003715:Dengue / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D003716:Dengue Virus / Q000276:immunology*; D019353:Endemic Diseases / Q000517:prevention & control; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines