title: [Clinical study of shenqi fuzheng injection and chemotherapy in CHOP protocol in treating malignant lymphoma].
abstract: OBJECTIVE
  To compare the efficacy and adverse reaction of chemotherapy in CHOP protocol (CT-CHOP) alone or compared with Shenqi Fuzheng injection (SFI) for treatment of moderate malignant non-Hodgkin's lymphoma.
  
  
  METHODS
  Sixty patients were divided into 2 groups, the treated group (n = 32) treated with CT-CHOP plus SFI for 5.7 cycles on average and the control group (n = 28) treated with CT-CHOP alone for 5.6 cycles on average.
  
  
  RESULTS
  In the treated group, 18 patients were completely remitted (CR), 4 were partially remitted (PR), 7 were unchanged (NC), 3 were progressively deteriorated (PD), with the total remission rate of 68.8%, while in the control group, 13 were CR, 4 PR, 7 NC and 4 PD, the total remission rate being 60.7%. After treatment, the levels of CD3, CD4 and CD4/CD8 increased and CD8 decreased significantly in the treated group (P <0.05). Patients' quality of life (QOL) in the treated group was improved more obviously than that in the control group (P < 0.01), and the incidence rate of adverse reaction as leucopenia, neurotoxicity, and cardiac toxicity were lower in the treated group than those in the control group (P<0.01).
  
  
  CONCLUSIONS
  Shenqi Fuzheng injection combined with CT-CHOP on malignant non-Hodgkin's lymphoma can reduce the adverse reaction of chemotherapy, ameliorate the compliance of patients to chemotherapy, and improve the immune function and QOL of patients.
authors.affiliation: Department of Oncology, Affiliated Hospital of Guiyang Medical College. wwlmn9666@vip.sina.com.cn
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Wang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Wen
authors.forename: Lei
authors.initials: L
authors.lastname: Han
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011241:Prednisone / Q000008:administration & dosage; D011788:Quality of Life; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D004365:Drugs, Chinese Herbal; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone