Prevalence and antifungal susceptibility of yeasts obtained from the oral cavity of elderly individuals.
Infections caused by Candida yeasts are common in elderly individuals. Seventy-five isolates of Candida spp. were obtained from saliva samples of 136 institutionalized elderly individuals resident in six retirement homes of Belo Horizonte, Brazil. Forty-seven isolates (62.66%) were identified as Candida albicans, 15 (20%) as C. tropicalis, 7 (9.33%) as C. glabrata, 4 (5.33) as C. parapsilosis, and 2 (2.67%) as C. guilliermondii. Among the 136 elderly individuals studied, 49 (36%) were male and 87 (64%) were female. Ages ranged from 60 to 90 years old. Sixty-three (46.3%) of the institutionalized individuals were denture wearers and, among them, 53 (84.1%) carried Candida yeasts in the oral cavity. Forty-four subjects presented lesions in the oral mucosa and among these, 36 (82%), had positive culture for Candida spp. The samples were tested for the in vitro susceptibility to amphotericin B, itraconazole, fluconazole and 5-flucytosin, and great variations were observed in the minimum inhibitory concentrations (MIC) of these drugs according to the species.
de Resende
Maria Aparecida
MA
Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos, 6627, Post office box 486, 31 270-901, Belo Horizonte, MG, Brazil. maresend@icb.ufmg.br
de Sousa
Lourimar Viana Nascimento Franco
LV
de Oliveira
Rita Cássia Botelho Weikert
RC
Koga-Ito
Cristiane Yumi
CY
Lyon
Juliana Pereira
JP
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D003778:Dentures / Q000009:adverse effects; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence
D000935:Antifungal Agents