Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine.
[Structure: see text] The asymmetric synthesis of a highly functionalized tetrahydroisoquinoline relevant to the total synthesis of Et-743 is described. The key step involves a highly diastereoselective radical cyclization on a glyoxalimine derivative.
Fishlock
Dan
D
Department of Chemistry, Colorado State University, Fort Collins 80523-1872, and University of Colorado Cancer Center, Aurora, Colorado 80045, USA.
Williams
Robert M
RM
D003500:Cyclization; D004149:Dioxoles / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis*; D000077606:Trabectedin
D004149:Dioxoles; D007097:Imines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin