title: Replicon typing of plasmids encoding resistance to newer beta-lactams.
abstract: Polymerase chain reaction-based replicon typing represents a novel method to describe the dissemination and follow the evolution of resistance plasmids. We used this approach to study 26 epidemiologically unrelated Enterobacteriaceae and demonstrate the dominance of incompatibility (Inc) A/C or Inc N-related plasmids carrying some emerging resistance determinants to extended-spectrum cephalosporins and carbapenems.
authors.affiliation: Department of Infectious, Parasituc, Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy. alecara@iss.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
authors.forename: Vivi
authors.initials: V
authors.lastname: Miriagou
authors.forename: Alessia
authors.initials: A
authors.lastname: Bertini
authors.forename: Alexandra
authors.initials: A
authors.lastname: Loli
authors.forename: Celine
authors.initials: C
authors.lastname: Colinon
authors.forename: Laura
authors.initials: L
authors.lastname: Villa
authors.forename: Jean M
authors.initials: JM
authors.lastname: Whichard
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012093:Replicon / Q000235:genetics*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012680:Sensitivity and Specificity; D018440:beta-Lactam Resistance / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams