A bacterial virulence protein suppresses host innate immunity to cause plant disease.
Plants have evolved a powerful immune system to defend against infection by most microbial organisms. However, successful pathogens, such as Pseudomonas syringae, have developed countermeasures and inject virulence proteins into the host plant cell to suppress immunity and cause devastating diseases. Despite intensive research efforts, the molecular targets of bacterial virulence proteins that are important for plant disease development have remained obscure. Here, we show that a conserved P. syringae virulence protein, HopM1, targets an immunity-associated protein, AtMIN7, in Arabidopsis thaliana. HopM1 mediates the destruction of AtMIN7 via the host proteasome. Our results illustrate a strategy by which a bacterial pathogen exploits the host proteasome to subvert host immunity and causes infection in plants.
Nomura
Kinya
K
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA.
Debroy
Sruti
S
Lee
Yong Hoon
YH
Pumplin
Nathan
N
Jones
Jonathan
J
He
Sheng Yang
SY
D020727:ADP-Ribosylation Factors / Q000378:metabolism; D017360:Arabidopsis / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D020126:Brefeldin A / Q000494:pharmacology; D005936:Glucans / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D007113:Immunity, Innate; D009154:Mutation; D010935:Plant Diseases / Q000382:microbiology*; D018515:Plant Leaves / Q000378:metabolism / Q000382:microbiology; D030821:Plants, Genetically Modified; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D021381:Protein Transport; D044224:Pseudomonas syringae / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D014026:Nicotiana / Q000378:metabolism; D020798:Two-Hybrid System Techniques; D014452:Ubiquitins / Q000378:metabolism; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*
D029681:Arabidopsis Proteins; C512008:At3g43300 protein, Arabidopsis; D001426:Bacterial Proteins; D005936:Glucans; D020662:Guanine Nucleotide Exchange Factors; D014452:Ubiquitins; D037521:Virulence Factors; D020126:Brefeldin A; C048306:callose; D046988:Proteasome Endopeptidase Complex; D020727:ADP-Ribosylation Factors