title: Measles virus-specific IgG4 antibody titer as a serologic marker of post-vaccinal immune response.
abstract: In previous research, we concluded that measles virus specific IgG4 antibody titer could be used to differentiate between natural [IgG4 GMT 80 (95% CI, 33 to 191)] and vaccinal source of measles infection [IgG4 GMT 13 (95% CI, 7 to 26)]. The aim of this paper is to show that this new serologic marker (IgG4 measles antibody titer) can be applied to help interpret rare but well documented cases of measles Ig M-positive results in vaccinated individuals who, 1-2 months after vaccination, developed rash and fever and therefore do not meet the criteria for post-vaccinal measles infection. Six measles IgM-positive serum samples obtained from measles vaccinated individuals who developed rash/fever 1 to 2 months post-vaccination were studied by Immunofluorescence assay for the quantification of IgG4 measles specific antibody. IgG4 antibody titers from all these samples were between 1:10-1:20, consequently, the IgM positive results from the study cases could be ascribed to post-vaccinal immune response. Thus, measles virus specific IgG4 antibody titer could be used as a serologic marker of post-vaccinal immune response.
authors.affiliation: Instituto de Virología Dr. J.M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, Ciudad Universitaria, Córdoba, Argentina.
authors.forename: María B
authors.initials: MB
authors.lastname: Isa
authors.forename: Laura C
authors.initials: LC
authors.lastname: Martínez
authors.forename: Leonardo J
authors.initials: LJ
authors.lastname: Ferreyra
authors.forename: Miguel O
authors.initials: MO
authors.lastname: Giordano
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Barril
authors.forename: Gisela
authors.initials: G
authors.lastname: Massachessi
authors.forename: Silvia V
authors.initials: SV
authors.lastname: Nates
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D015415:Biomarkers / Q000097:blood*; D005076:Exanthema / Q000276:immunology; D005334:Fever / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008457:Measles / Q000276:immunology / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology; D008459:Measles virus / Q000276:immunology* / Q000472:pathogenicity; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008458:Measles Vaccine