A new nucleoside derivative, AJP117510, as an inhibitor of integrin alpha2beta1-collagen binding.
A new nucleoside derivative, AJP117510 (1) was isolated from unidentified fungus AJ117510. The structure of 1 was elucidated by spectroscopic analyses. Nucleoside 1 inhibited the binding of integrin alpha2beta1 to collagen in a dose dependent manner with an IC50 value of 5.9 microM.
Sato
Seiichi
S
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki 210-8681, Japan. seiichi_sato@ajinomoto.com
Futaki
Fumie
F
Fukuchi
Naoyuki
N
Kaida
Kenichi
K
Hiraga
Masako
M
Kobaru
Seikichi
S
Tsuji
Takashi
T
D003094:Collagen / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000737:chemistry; D038982:Integrin alpha2beta1 / Q000378:metabolism*; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D013057:Spectrum Analysis; D014529:Uridine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014574:Uronic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C512211:AJP 117510; D038982:Integrin alpha2beta1; D009705:Nucleosides; D014574:Uronic Acids; D003094:Collagen; D014529:Uridine