title: Accuracy of physical working capacity 170 to estimate aerobic fitness in prepubertal diabetic boys and in 2 insulin dose conditions.
abstract: OBJECTIVE
  Exercise tests evaluate the effects of physical activity, which is one of the four recommendations for diabetes treatment. An adjusted and accurate measure of aerobic capacity in diabetic patients is thus needed. This study compared two estimates of aerobic fitness (maximal oxygen uptake vs physical working activity PWC170, i.e., the workload at a pulse of 170) and the usual versus a reduced insulin dose in preadolescent boys with type 1 diabetes mellitus.
  
  
  METHODS
  Sixteen prepubertal type 1 diabetic boys performed a submaximal test, the PWC(170). Gas exchange values and capillary blood glucose levels were monitored and, when possible, the test was extended to exhaustion. In 7 boys, the test was performed twice on separate days. On one day they received their usual insulin dose and on the other, their short-acting insulin was reduced by 1/3; the two tests were held in random order. The 9 other children were tested only once after receiving their usual insulin dose.
  
  
  RESULTS
  For the 16 boys who performed the test with the usual insulin dose, PWC(170) (W) and peak oxygen uptake (peak VO(2)) (L.min(-1)) correlated closely (r=0.81, P=0.002). Aerobic fitness did not change with insulin dose, but some hypoglycemic episodes occurred when insulin dose was not reduced.
  
  
  CONCLUSIONS
  Since maximal effort does not add more information, routine use of the submaximal peak VO(2)-correlated test, the PWC(170), seems sufficient, possibly in association with a planned insulin dose reduction. This dose change does not interfere with performance, but could reduce the risk of hypoglycemia.
authors.affiliation: Department of Pediatric Endocrinology, University Hospital of Rennes, Rennes, France. elsaheyman@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Heyman
authors.forename: D
authors.initials: D
authors.lastname: Briard
authors.forename: M
authors.initials: M
authors.lastname: Dekerdanet
authors.forename: A
authors.initials: A
authors.lastname: Gratas-Delamarche
authors.forename: P
authors.initials: P
authors.lastname: Delamarche
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D015203:Reproducibility of Results; D014938:Work Capacity Evaluation
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin