Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci.
Viridans streptococci are a major cause of infective endocarditis, and penicillin non-susceptibility is increasing in these organisms. We present the initial reported case of infective endocarditis due to penicillin non-susceptible viridans streptococci successfully treated with ceftriaxone monotherapy. The lack of evidence supporting the recommendations for treatment of endocarditis due to penicillin non-susceptible viridans streptococci is discussed.
Shelburne
Samuel A
SA
Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, N-1319, BCM-286, 1 Baylor Plaza, Houston, TX 77030, USA. samuels@bcm.tmc.edu
Greenberg
Stephen B
SB
Aslam
Saima
S
Tweardy
David J
DJ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010403:Penicillin Resistance; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome; D034363:Viridans Streptococci / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone