Vertical transmission of bovine viral diarrhoea virus (BVDV) in mousedeer (Tragulus javanicus) and spread to domestic cattle.
This study investigates the transmission of bovine viral diarrhoea virus (BVDV) 1f from a persistently infected (PI) lesser Malayan mousedeer to two bovine calves. Different contact routes to two calves were analysed: 1) aerosol contact between two adjacent pens without physical contact; 2) indirect contact by use of common utensils; 3) direct nose-to-nose contact for 30 seconds. One of the calves was infected either by aerosol or indirect contact. The virus sequence in 247 nucleotides in the 5'-UTR was 100% identical in mousedeer and calf. To elucidate the distribution of BVDV within the affected mousedeer family the captive population in a Zoo was analysed. The maternal line of PI animals was maintained, whereas a PI male was able to reproduce and have a non-PI calf. As a consequence of this, six female PI mousedeer were killed; subsequent autopsies did not reveal any lesions. Sequencing mousedeer BVD virus in the E2 region (420 nucleotides) through 4 generations showed only 7 mutations, which were maintained from mother to offspring.
Uttenthal
A
A
Department of Virology, Danish Institute for Food and Veterinary Research, Lindholm, Kalvehave, Denmark. AAU@DFVF.DK
Hoyer
M J
MJ
Grøndahl
C
C
Houe
H
H
van Maanen
C
C
Rasmussen
T B
TB
Larsen
L E
LE
D000336:Aerosols; D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000821:virology*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D003670:Deer / Q000821:virology*; D001908:Diarrhea Viruses, Bovine Viral / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D030243:Hemorrhagic Syndrome, Bovine / Q000635:transmission*; D018445:Infectious Disease Transmission, Vertical; D008969:Molecular Sequence Data; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012418:Ruminants / Q000821:virology
D000336:Aerosols; D004279:DNA, Viral