title: HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics.
abstract: BACKGROUND
  Accurate interpretation of data obtained by unsupervised analysis of large scale expression profiling studies is currently frequently performed by visually combining sample-gene heatmaps and sample characteristics. This method is not optimal for comparing individual samples or groups of samples. Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata.
  
  
  RESULTS
  We have developed a tool called the HeatMapper that provides such visualizations in a dynamic and flexible manner and is available from http://www.erasmusmc.nl/hematologie/heatmapper/.
  
  
  CONCLUSIONS
  The HeatMapper allows an accessible and comprehensive visualization of the results of gene expression profiling and cluster analysis.
authors.affiliation: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. r.verhaak@erasmusmc.nl
authors.forename: Roel G W
authors.initials: RG
authors.lastname: Verhaak
authors.forename: Mathijs A
authors.initials: MA
authors.lastname: Sanders
authors.forename: Maarten A
authors.initials: MA
authors.lastname: Bijl
authors.forename: Ruud
authors.initials: R
authors.lastname: Delwel
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Horsman
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Moorhouse
authors.forename: Peter J
authors.initials: PJ
authors.lastname: van der Spek
authors.forename: Bob
authors.initials: B
authors.lastname: Löwenberg
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Valk
mesh_terms: D018952:Antigens, CD34 / Q000235:genetics; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D020869:Gene Expression Profiling / Q000379:methods*; D005838:Genotype; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D000090243:Nucleophosmin; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010641:Phenotype; D012984:Software
chemical_list: D018952:Antigens, CD34; D009687:Nuclear Proteins; D000090243:Nucleophosmin