Synthesis and cardiac effects of 3,4-dihydropyrimidin-2(1H)-one-5 carboxylates.
A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.
Sujatha
Kuppusamy
K
Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (DU), Porur, Chennai 600 116, India.
Shanmugam
Pachaiyappan
P
Perumal
Paramasivam T
PT
Muralidharan
Doraisamy
D
Rajendran
Melani
M
D000818:Animals; D001001:Anura; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry*
D002264:Carboxylic Acids; D011743:Pyrimidines; D006859:Hydrogen; C030986:pyrimidine