Interactions between nonionic Triton X surfactants and cholesterol-containing phosphatidylcholine liposomes.
Solubilization kinetics experiments were developed to study the effects of the polyethylene glycol chain length of Triton X surfactants on their interactions with the cholesterol-containing phosphatidylcholine vesicles. An empirical liposome stability ratio was used to describe the vesicle solubilization process. The effectiveness of Triton X surfactants in solubilizing vesicles decreases with increasing polyethylene glycol chain length of surfactants. It was also shown that vesicles containing the intercalated surfactant molecules with the largest number of ethylene glycol units per molecule exhibited the exceedingly retarded solubilization behavior. Independent experiments based on a thermodynamic approach provide supporting evidence for the conclusions obtained from solubilization kinetics experiments.
Chern
Chorng-Shyan
CS
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Chiu
Hsin-Cheng
HC
Yang
Yu-Shiue
YS
D002784:Cholesterol / Q000737:chemistry*; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry*; D017830:Octoxynol / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D013997:Time Factors
D008081:Liposomes; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D017830:Octoxynol; D002784:Cholesterol