Synthesis and characterization of thiolate-Ag(I) complexes by solid-state and solution NMR and their antimicrobial activity.
Silver(I) complexes of several thiolates have been prepared. These complexes have been characterized by elemental analysis and 13C NMR spectroscopy. All the Ag(I)-thiolate complexes are polymeric in nature. Therefore, 13C CP MAS NMR is being used extensively to analyze the binding site of the ligand and the nature of complexation. A significant shift difference was observed for S binding site whereas smaller shift was observed for carboxylate binding site. The antimicrobial activities for Ag(I)-glutathione complex was measured and compared with Ag(I)-captopril complex.
Isab
Anvarhusein A
AA
Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. aisab@kfupm.edu.sa
Wazeer
Mohammed I M
MI
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D002216:Captopril / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012834:Silver / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D012834:Silver; D002216:Captopril