title: Evaluation of antiproliferative effect in vitro of some 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole derivatives.
abstract: New compounds of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set were synthesized and tested for their antiproliferative activity as part of our research in the antitumour field. Title compounds were obtained by reaction of sulfinylbis(2,4-dihydroxythiobenzoyl) (STB) with 4-substituted 3-thiosemicarbazides. The structures of compounds were identified from elemental, IR, 1H-, 13C-NMR and MS spectra analyses. The cytotoxicity in vitro against human bladder cancer HCV29T cells was determined. The most active compounds were also tested against human cancer cell lines: SW707 (rectal), A549 (lung) and T47D (breast). The antiproliferative effect of some compounds was higher than cisplatin studied comparatively.
authors.affiliation: Department of Chemistry, Agricultural University; Akademicka 15, 20-950, Lublin, Poland. joanna.matysiak@ar.lublin.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Matysiak
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013830:Thiadiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013830:Thiadiazoles; D002945:Cisplatin