title: Predictive capacity of pre-donation GFR and renal reserve capacity for donor renal function after living kidney donation.
abstract: Kidney transplantation from living donors is important to reduce organ shortage. Reliable pre-operative estimation of post-donation renal function is essential. We evaluated the predictive potential of pre-donation glomerular filtration rate (GFR) (iothalamate) and renal reserve capacity for post-donation GFR in kidney donors. GFR was measured in 125 consecutive donors (age 49 +/- 11 years; 36% male) 119 +/- 99 days before baseline GFR (GFRb) and 57 +/- 16 days after donation (GFRpost). Reserve capacity was assessed as GFR during stimulation by low-dose dopamine (GFRdopa), amino acids (GFRAA) and both (GFRmax). GFRb was 112 +/- 18, GFRdopa 124 +/- 22, GFRAA 127 +/- 19 and GFRmax 138 +/- 22 mL/min. After donation, GFR remained 64 +/- 7%. GFRpost was predicted by GFRb(R2 = 0.54), GFRdopa(R2 = 0.35), GFRAA(R2 = 0.56), GFRmax(R2 = 0.55)and age (R2 = -0.22; p < 0.001 for all). Linear regression provided the equation GFRpost = 20.01 + (0.46*GFRb). Multivariate analysis predicted GFRpost by GFRb, age and GFRmax(R2 = 0.61, p < 0.001). Post-donation renal function impairment (GFR < or = 60 mL/min/1.73 m2) occurred in 31 donors. On logistic regression, GFRb, body mass index (BMI) and age were independent predictors for renal function impairment, without added value of reserve capacity. GFR allows a relatively reliable prediction of post-donation GFR, improving by taking age and stimulated GFR into account. Long-term studies are needed to further assess the prognostic value of pre-donation characteristics and to prospectively identify subjects with higher risk for renal function loss.
authors.affiliation: Department of Medicine, Renal Transplant Unit, University Medical Center, Groningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Rook
authors.forename: H S
authors.initials: HS
authors.lastname: Hofker
authors.forename: W J
authors.initials: WJ
authors.lastname: van Son
authors.forename: J J
authors.initials: JJ
authors.lastname: Homan van der Heide
authors.forename: R J
authors.initials: RJ
authors.lastname: Ploeg
authors.forename: G J
authors.initials: GJ
authors.lastname: Navis
mesh_terms: D046148:Donor Selection; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D019520:Living Donors / Q000145:classification; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy