International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future.
OBJECTIVE
To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL).


METHODS
NIH campus workshop discussion focusing on future work in both clinical and basic lymphoma research.


RESULTS
The discussion lead to recommendations on elucidating disease pathobiology, improving diagnostic accuracy and sensitivity, and novel therapeutic strategies.


CONCLUSIONS
Approaches which have been successfully applied to other neoplasms, such as microarray, may be applied to improve diagnostic accuracy and sensitivity of PCNSL and PIOL and should be systematically incorporated into clinical trials of both. Development of animal models of PCNSL and PIOL may be useful in understanding the unique ocular and CNS milieu. Disease detection by radiological, nuclear medicine, molecular and flow cytometric approaches should be systematically studied to improve early diagnosis, accurate staging, and response evaluation. Improved therapy remains the ultimate goal. Efforts in these arenas should be coordinated on a national and international level.
Nussenblatt
Robert B
RB
Laboratory of Immunology, National Eye Institute, NIH, 10 Center Drive, Building 10, Room 10S219, Bethesda, MD, 20892, USA. DrBob@nei.nih.gov
Chan
Chi-Chao
CC
Wilson
Wyndham H
WH
Hochman
Jacob
J
Gottesman
Michael
M
D000818:Animals; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging / Q000379:methods; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007391:International Cooperation; D008223:Lymphoma / Q000175:diagnosis* / Q000628:therapy*; D009316:National Institutes of Health (U.S.); D017410:Practice Guidelines as Topic; D014481:United States