title: High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11).
abstract: In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation-specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing effect of the der(22) for breast and brain tumor development in this family.
authors.affiliation: Institut für Humangenetik, Otto-von-Guericke-Universität, Magdeburg, Germany.
authors.forename: Ilse
authors.initials: I
authors.lastname: Wieland
authors.forename: Petra
authors.initials: P
authors.lastname: Muschke
authors.forename: Marianne
authors.initials: M
authors.lastname: Volleth
authors.forename: Albrecht
authors.initials: A
authors.lastname: Röpke
authors.forename: Antje-Friederike
authors.initials: AF
authors.lastname: Pelz
authors.forename: Markus
authors.initials: M
authors.lastname: Stumm
authors.forename: Peter
authors.initials: P
authors.lastname: Wieacker
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic