title: Liver haemorrhage in haemophilia--a case report and review of the literature.
abstract: We present two patients with severe haemophilia A, who presented with haemorrhagic shock, secondary to a liver haematoma in the neonatal period. Both required emergency treatment and diagnosis of the hereditary coagulation defect. Major organ bleeding in severe haemophilia A in the newborn period is rare, and this unusual complication is not well recognized. Failure to recognize that the bleeding is due to a bleeding disorder, particularly in the absence of a family history, may lead to delay in appropriate management.
authors.affiliation: Haematology Department, University Hospital of Wales, Cardiff, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hamilton
authors.forename: W
authors.initials: W
authors.lastname: French
authors.forename: N
authors.initials: N
authors.lastname: Rhymes
authors.forename: P
authors.initials: P
authors.lastname: Collins
mesh_terms: D000328:Adult; D003029:Coagulants / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D014463:Ultrasonography
chemical_list: D003029:Coagulants; D005169:Factor VIII