title: Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth.
abstract: BACKGROUND
  Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated.
  
  
  METHODS
  Forty-four surgically-resected human lung cancer tissues were xenotransplanted into SCID mice. Their blood was collected and the volume of the transplanted tumors was measured regularly. The correlations between the IgG titer in the sera and the growth of the transplanted tumors according to the clinicopathological variables were examined.
  
  
  RESULTS
  Human IgG production from TIB was observed in the all xenotransplanted mice. Twenty-seven out of the 44 tumors regressed gradually. The average serum human IgG level of the tumor regressors (n = 10) was significantly higher than that of the progressors (n = 9) in squamous cell carcinoma (p = 0.02), while there was no significant difference in the other histological groups.
  
  
  CONCLUSIONS
  IgG produced by TIB might play a crucial role in preventing tumor growth in squamous cell carcinoma.
authors.affiliation: Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan. macky@med.uoeh-u.ac.jp
authors.forename: Makiko
authors.initials: M
authors.lastname: Mizukami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanagiri
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Baba
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Nagata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: So
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ichiki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugaya
authors.forename: Manabu
authors.initials: M
authors.lastname: Yasuda
authors.forename: Tomoko
authors.initials: T
authors.lastname: So
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takenoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugio
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D048708:Cell Growth Processes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
chemical_list: D007074:Immunoglobulin G