title: TSH and bone loss.
abstract: We have recently challenged the view that the bone loss associated with hyperthyroidism is solely due to elevated thyroid hormone levels. We find that thyroid-stimulating hormone (TSH), derived from the anterior pituitary gland, inhibits bone resorption by the osteoclast. Mice haploinsufficient in the TSH receptor show reduced bone density and evidence of enhanced bone resorption in the face of normal thyroid function. In humans, TSH inhibits markers of bone resorption with a single administration, and low TSH levels correlate with increased fracture risk. The evidence that low TSH levels predispose to osteoporosis in hyperthyroidism is discussed in view of the emerging role of pituitary hormones in bone biology.
authors.affiliation: Department of Medicine, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Terry F
authors.initials: TF
authors.lastname: Davies
authors.forename: Harry C
authors.initials: HC
authors.lastname: Blair
authors.forename: Etsuko
authors.initials: E
authors.lastname: Abe
authors.forename: Mone
authors.initials: M
authors.lastname: Zaidi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology*; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D011989:Receptors, Thyrotropin / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D013972:Thyrotropin / Q000502:physiology*
chemical_list: D011989:Receptors, Thyrotropin; D013972:Thyrotropin