title: Recipient age and risk of chronic allograft nephropathy in primary deceased donor kidney transplant.
abstract: Single center and registry data studies have had conflicting results regarding the impact of recipient age on chronic allograft nephropathy (CAN). We tested the hypothesis that advanced recipient age is a risk factor for graft failure due to CAN. All patients who underwent primary deceased donor kidney transplant between January 1, 1995 and December 31, 2000 recorded in the United Network of Organ Sharing (UNOS) database were analyzed for the occurrence of death censored graft loss and by two different definitions of graft loss due to CAN. Kaplan-Meier analysis based on the recipient age, and Cox proportional hazard regression was used to estimate the independent effect of recipient age on the three endpoints of interest. For all endpoints, after age of 9 years, the risk of graft loss declined with each successive decade increase in age. This pattern of risk was similar for both Caucasian and African-American recipients, although for any given age the risk of graft loss was always higher in African-American recipients. Analysis of UNOS data does not support the hypothesis that advanced recipient age is a risk factor for CAN.
authors.affiliation: Department of Medicine, Multi-organ Transplant Program, McGill University Health Center, Montreal, QC, Canada. douglas.keith@muhc.mcgill.ca
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Keith
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cantarovich
authors.forename: Steven
authors.initials: S
authors.lastname: Paraskevas
authors.forename: Jean
authors.initials: J
authors.lastname: Tchervenkov
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D016208:Databases, Factual; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014019:Tissue Donors; D014481:United States; D044465:White People