title: [Prognostic value of E-cadherin, CD34 in the patients with hepatocellular carcinoma].
abstract: OBJECTIVE
  To study the expression of E-cadherin and CD34 in the tissues of hepatocellular carcinoma (HCC), to discuss the relationship between them and the clinical pathology and evaluate the prognosis of HCC patients.
  
  
  METHODS
  The expression of E-cadherin and CD34 in HCC tissues of 41 patients were examined by two-step methods of PV-6000 of immunohistochemistry. Clinical-pathological data, tumor recurrent rate and survival rate after hepatectomy were recorded and analyzed.
  
  
  RESULTS
  The positive expression rate was observed in 48.78% for E-cadherin and 100% for CD34. The decreased E-cadherin expression were significantly associated with larger tumor, the high-dangerous group with invasion and poor differentiation of HCC tissues (chi(2) = 4.1881, 4.8118, 6.2695, P < 0.05). In the group with negative-expression of E-cadherin, the percent of tumor recurrence within 2 years after hepatectomy was higher and the rate of 5 years survival was significantly lower than the positive-expressed group. A significant negative-correlation between the expression of CD34 and the patients' age and the invasion of tumor (t = 1.9371, 1.9010, P < 0.05) were found. There was no relationship between the expression of E-cadherin and CD34 in HCC tissues.
  
  
  CONCLUSIONS
  The patient with a negative-expression of E-cadherin in HCC tissues has a poor prognosis. No relationship between the expression of CD34 and tumor recurrence and patients' survival and no relationship between the expression of E-cadherin and CD34 was found.
authors.affiliation: Department of Hepatobiliary and Vascular Surgery, The Affiliated Hospital of QingDao University Medical College, QingDao 266003, China. wulq5810@163.com
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Hua-jun
authors.initials: HJ
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Jin-yong
authors.initials: JY
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate
chemical_list: D018952:Antigens, CD34; D015820:Cadherins