The role of Salicornia herbacea in ovariectomy-induced oxidative stress.
Ovarian hormone deficiency increases the generation of reactive oxygen species. Their excess induces oxidative stress, which results in the cell damage or death. It causes the aging diseases-atherosclerosis, rheumatoid arthritis, osteoporosis, etc. Ovariectomized rats are used as oxidative stress models. We verified the effects of ovariectomy-induced oxidative stress on free radical production as evaluated by DPPH elimination, lipoperoxidation evaluated by malondialdehyde levels, and antioxidant activation of superoxide dismutase, catalase, glutathione peroxidase, and estradiol in the liver and sera. Ovariectomized rats were given Salicornia herbacea (SH) intraperitoneally at the dose of 100 mg/kg daily for 2 months. Free radical-scavenging activity of SH was measured in comparison with that of L-ascorbic acid. The histopathology of liver tissue was also investigated. Antioxidative values in the ovariectomized group decreased, but those in the SH-treated group increased due to the free radical-scavenging activity of SH. Moreover, inflammation and cirrhosis in the liver tissue of SH-treated rats decreased significantly. These results suggest that SH may be a potential candidate for an antioxidative reagent.
Ha
Bae Jin
BJ
Department of Bioscience and Biotechnology, Silla University, Busan, Korea. bjha@silla.ac.kr
Lee
Sang Hun
SH
Kim
Hee Jin
HJ
Lee
Jin Young
JY
D000818:Animals; D002374:Catalase / Q000378:metabolism; D019663:Chenopodiaceae; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D010052:Ovariectomy; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D016166:Free Radical Scavengers; D010936:Plant Extracts; D002374:Catalase; D013482:Superoxide Dismutase