title: Sex chromosome aneuploidy rates in the somatic cells of infertile men.
abstract: OBJECTIVE
  A large number of studies have shown that the prevalence of somatic chromosome abnormalities detectable with karyotyping is higher in infertile men. However, a normal somatic karyotype does not exclude the chance of having low level mosaicism.
  
  
  METHODS
  Eleven men with severe oligozoospermia and 10 healthy, fertile men were included in this study. All the patients had severe oligozoospermia with sperm counts < or =3,000,000/ mL. All participants had normal physical findings and testicular volume. The probe for dual-color fluorescence in situ hybridization consisted of an alpha satellite sequence in the centromeric region of chromosome X (DXZ1) and satellite III DNA at the Yq12 region of chromosome Y (DYZ1).
  
  
  RESULTS
  The sex chromosome aneuploidy rate was significantly higher in subjects than in controls (p<0.001). The median incidence of sex chromosome aneuploidy in the oligozoospermic group was 4.5% (range, 0.8-7.3%), while in the control group it was 0.7% (range, 0.2-1.2%).,
  
  
  CONCLUSIONS
  The incidence of aneuploidy in somatic cells is significantly greater in oligozoospermic men than in normal controls. That may suggest that chromosome instability is a result of altered genetic control during mitotic cell division. Our results demonstrate that men with oligozoospermia have an elevated risk for sex chromosome abnormalities in their somatic cells.
authors.affiliation: Departments of Medical Biology, Biochemistry and Urology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. fduzcan@hotmail.com
authors.forename: Fusun
authors.initials: F
authors.lastname: Duzcan
authors.forename: Zafer
authors.initials: Z
authors.lastname: Aybek
authors.forename: Emre
authors.initials: E
authors.lastname: Tepeli
authors.forename: Vildan
authors.initials: V
authors.lastname: Caner
authors.forename: Gokhan Ozan
authors.initials: GO
authors.lastname: Cetin
authors.forename: Hulya
authors.initials: H
authors.lastname: Aybek
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bagci
mesh_terms: D000328:Adult; D000782:Aneuploidy; D041322:Chromosomes, Human, Y / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics; D012729:Sex Chromosome Aberrations