[Studying the hepatoprotector effect of bemithyl on a model of chronic toxic liver damage].
A prophylactic and therapeutic introduction of the synthetic adaptogen bemithyl (2-ethylthiobensimidasole hydrobromide) produces a hepatoprotector effect in rats with experimental cirrhosis. The drug exhibits an anticytolytic activity, restores liver participation in the pigment exchange, and normalizes the function of the microsomal oxidation system responsible for the metabolism of xenobiotics. The treatment with bemithyl also leads to a certain improvement of a histologic picture of the damaged liver and to a decrease in the degree of fibrosis. The drug is also capable of increasing the activity of the antioxidant system and inhibiting the process of lipid peroxidation of proteins and lipids in the liver.
Oskovityĭ
S V
SV
Bezborodkina
N N
NN
Zarubina
I V
IV
Mironova
O P
OP
Kudrivtsev
B N
BN
Shulenin
S N
SN
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D002908:Chronic Disease; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats
D000975:Antioxidants; D001562:Benzimidazoles; D020011:Protective Agents; C049825:bemethyl