title: [Genetic polymorphism of 23 Y chromosome biallelic markers in Wuhan Han population].
abstract: To search polymorphic Y chromosome biallelic markers in Chinese Han population, and obtain their population genetic data. Genotyping of 23 biallelic markers on human Y chromosome (M7, M9, M50, M88, M89, M95, M111, M117, M119, M121, M122, M134, M159, M164, M175, M214, LINE1, MSY2, RPS4Y711, SRY465, IMS-JST164520, IMS-JST021354 and IMS-JST003305) were carried out in a sample of 160 unrelated Chinese male individuals living in Wuhan using fragment length discrepant allele specific PCR (FLDAS-PCR) and PAGE technique. In all 23 biallelic markers, genetic polymorphism were identified for 20 loci in Wuhan Han population except for M50, M159 and M164, and the ranges of gene diversity (GD) were 0.0126-0.4855. A total of 35 different haplogroups (Hg1-35) were observed and the haplogroup diversity (HD) was 0.9471. The haplogroups formed by 20 biallelic markers are highly polymorphic, and can be used in forensic science and population evolution studies.
authors.affiliation: Faculty of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. huangdaixin@mails.tjmu.edu.cn
authors.forename: Dai-Xin
authors.initials: DX
authors.lastname: Huang
authors.forename: Qing-En
authors.initials: QE
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Yin
authors.forename: Xian-Dun
authors.initials: XD
authors.lastname: Zhai
authors.forename: Rong-Zhi
authors.initials: RZ
authors.lastname: Yang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers