The function of apolipoproteins L.
The function of the proteins of the apolipoprotein L (apoL) family is largely unknown. These proteins are classically thought to be involved in lipid transport and metabolism, mainly due to the initial discovery that a secreted member of the family, apoL-I, is associated with high-density lipoprotein particles. However, the other members of the family are believed to be intracellular. The recent unravelling of the mechanism by which apoL-I kills African trypanosomes, as well as the increasing evidence for modulation of apoL expression in various pathological processes, provides new insights about the functions of these proteins. ApoLs share structural and functional similarities with proteins of the Bcl-2 family. Based on the activity of apoL-I in trypanosomes and the comparison with Bcl-2 proteins, we propose that apoLs could function as ion channels of intracellular membranes and be involved in mechanisms triggering programmed cell death.
Vanhollebeke
B
B
Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, 6041 Gosselies, Belgium.
Pays
E
E
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D007473:Ion Channels / Q000502:physiology; D008075:Lipoproteins, HDL / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008247:Lysosomes / Q000502:physiology; D008969:Molecular Sequence Data; D005810:Multigene Family; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014346:Trypanosoma brucei brucei / Q000187:drug effects
C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D007473:Ion Channels; D008075:Lipoproteins, HDL; D019253:Proto-Oncogene Proteins c-bcl-2