title: TAOS1, a novel marker for advanced esophageal squamous cell carcinoma.
abstract: BACKGROUND
  TAOS1 (tumor amplified and overexpressed sequence 1) was recently cloned and found to be possibly important in driving the amplification of 11q13 in oral squamous cell carcinoma (SCC).
  
  
  METHODS
  Quantitative RT-PCR was performed to determine the possible relationship between TAOS1 gene expression levels and clinicopathological features in esophageal SCC.
  
  
  RESULTS
  TAOS1 overexpression was observed in 7 out of 38 (18%) esophageal SCCs and CCND1 overexpression was observed in 4 out of 38 (11%), suggesting that TAOS1 was more frequently overexpressed than CCND1 in esophageal SCC. The examination of the correlation of TAOS1 overexpression with the clinicopathological features revealed a significant difference in lymph node metastasis (p = 0.014) and a trend towards advanced TNM stages (p = 0.074).
  
  
  CONCLUSIONS
  The present results suggest that TAOS1 might serve as a new marker for predicting the malignancy of esophageal SCC.
authors.affiliation: Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Hibi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kodera
authors.forename: Seiji
authors.initials: S
authors.lastname: Akiyama
authors.forename: Katsuki
authors.initials: K
authors.lastname: Ito
authors.forename: Akimasa
authors.initials: A
authors.lastname: Nakao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000096:biosynthesis / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012337:RNA, Ribosomal, 18S / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C465628:LTO1 protein, human; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012337:RNA, Ribosomal, 18S; D019938:Cyclin D1