title: Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma.
abstract: This article is a case report of a high grade, radio-induced, breast malignant fibrous histiocytoma (undifferentiated high grade pleomorphic sarcoma), which developed in a 44-year old female, seven years after breast conservative surgery and radiotherapy for a T1N0M0 invasive left breast ductal carcinoma. The sarcoma presented as a fast growing tumour, 9.5 cm in the largest diameter, with skin, left breast, chest wall muscle and rib invasion. Neoadjuvant chemotherapy was performed with epirubicin and ifosfamide. Extended radical surgery according to oncological standards and soft tissue reconstruction were carried out. Despite bad prognostic features of high grade and large invasive sarcoma, the patient is currently, after 44 months of follow up, without local recurrence, or metastases, exceeding the 12.8-month mean recurrence period and mortality rate for these tumours larger than 8.1 cm (+/- 1.2 cm) as described in the literature.
authors.affiliation: Oncological Society of Bahia-ONCO, Salvador, Bahia, Brazil. caquadros0109@hotmail.com
authors.forename: Claudio Almeida
authors.initials: CA
authors.lastname: Quadros
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vasconcelos
authors.forename: Roque
authors.initials: R
authors.lastname: Andrade
authors.forename: Rogério Santos
authors.initials: RS
authors.lastname: Ramos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Studart
authors.forename: Geraldo
authors.initials: G
authors.lastname: Nascimento
authors.forename: André
authors.initials: A
authors.lastname: Trajano