Recovery of adenine nucleotide pool in the brain after craniocerebral trauma in rats: comparison of biochemical data with mathematical model.
A mathematical model is developed, which predicts the maximum deviation of adenine nucleotide content from the normal and the period of its restoration in the brain of animals. This model diminishes labor expenditures and duration of experimental studies. Moreover, it significantly increases the accuracy and reliability of the data. This model can assess the efficiency of pharmacotherapy of craniocerebral trauma aftereffects.
Zarubina
I V
IV
Department of Pharmacology, Military Medical Academy, St. Petersburg.
Kuritsyna
N A
NA
Nurmanbetova
F N
FN
Shabanov
P D
PD
D000225:Adenine / Q000737:chemistry; D000227:Adenine Nucleotides / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D001671:Biochemistry / Q000379:methods; D001921:Brain / Q000378:metabolism*; D006259:Craniocerebral Trauma / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D008962:Models, Theoretical; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors
D000227:Adenine Nucleotides; D000255:Adenosine Triphosphate; D000225:Adenine