title: Pressure-volume curves with and without muscle paralysis in acute respiratory distress syndrome.
abstract: OBJECTIVE
  Pressure-volume (PV) curves are recorded after induction of complete muscle paralysis, which may limit their clinical use. The feasibility of recording PV curves without paralysis has not been tested. In 19 patients with acute respiratory distress syndrome (ARDS) and no hemodynamic instability we prospectively evaluated whether PV curves can be safely and reliably recorded under deep sedation without neuromuscular blockade.
  
  
  METHODS
  After standardized sedation (continuous infusion of midazolam and fentanyl) PV curves were recorded during apneic sedation, defined as absence of respiratory effort during a 6-s expiratory pause and during paralysis induced by cis-atracurium.
  
  
  RESULTS
  Agreement between PV curve parameters in the two conditions was evaluated. Curves were obtained from 10 cmH2O and from zero end-expiratory pressure in all patients under apneic sedation. In five patients propofol was given in addition to midazolam and fentanyl, and in two of them fluid resuscitation was needed. A strong agreement was found for respiratory system compliance and the lower inflection point and for chest wall compliance in the five patients whose esophageal pressure was measured. The variability of the measurements, however, should be taken into account in clinical practice.
  
  
  CONCLUSIONS
  Neuromuscular blockade can be dispensed with when recording PV curves in many ARDS patients. Reliable PV curves can be obtained under anesthesia alone, with no serious adverse effects.
authors.affiliation: Medical Intensive Care Unit, Anesthesiology-Critical Care Unit, and Research Unit, INSERM U 651, AP-HP, Hôpital Henri Mondor, Faculté de Médecine, Université Paris XII, 94010, Créteil Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Decailliot
authors.forename: Alexandre
authors.initials: A
authors.lastname: Demoule
authors.forename: Salvatore Maurizio
authors.initials: SM
authors.lastname: Maggiore
authors.forename: Bjorn
authors.initials: B
authors.lastname: Jonson
authors.forename: Philippe
authors.initials: P
authors.lastname: Duvaldestin
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
mesh_terms: D000328:Adult; D000368:Aged; D001279:Atracurium / Q000008:administration & dosage; D016292:Procedural Sedation / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000187:drug effects*; D012307:Risk Factors; D013990:Tidal Volume
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium