Species distribution and antifungal susceptibility profile of oral candida isolates from HIV-infected patients in the antiretroviral therapy era.
In this study, we investigated the yeasts colonization of genus Candida, including C. dubliniensis, isolated of HIV-infected patients oral cavities and we accessed in vitro susceptibility pattern of the Candida isolates to four antifungal agents. Out of 99 patients investigated, 62 (62.6%) were colonized with yeasts. C. albicans was the prevailing species (50%). C. dubliniensis isolates were not recovered in our study. We verified that 8.1% of the yeasts isolated were resistant to fluconazole, 8.1% to itraconazole and 3.2% to voriconazole. The isolates demonstrated very low voriconazole MICs, in which 79% (49/62) presented values of 0.015 mug/ml. All Candida isolates were susceptible to amphotericin B. The results reported here showed that although C. albicans continues to be present in one-half of oral Candida carriage of HIV-infected patients, Candida non-albicans species are increasing among these patients. Besides, the findings of resistant isolates endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned.
Costa
Carolina Rodrigues
CR
Instituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás, Goiás, Brazil.
de Lemos
Janine Aquino
JA
Passos
Xisto Sena
XS
de Araújo
Crystiane Rodrigues
CR
Cohen
Ana Joaquina
AJ
Souza
Lúcia Kioko Hasimoto E
LK
Silva
Maria do Rosário Rodrigues
Mdo R
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000382:microbiology* / Q000821:virology*; D025141:Drug Resistance, Fungal; D005260:Female; D006678:HIV / Q000254:growth & development*; D015658:HIV Infections / Q000188:drug therapy / Q000382:microbiology* / Q000821:virology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents