[The prognostic role of gamma-glutamyltransferase for cardiovascular events].
Serum gamma-glutamyltransferasis activity is a low-cost, highly sensitive laboratory test. Though it is currently considered as an index of hepato-biliary dysfunction and alcohol abuse, recent epidemiological and pathologic studies have proposed its independent role in the pathogenesis and clinical evolution of cardiovascular diseases brought by atherosclerosis, associated with a gamma-glutamyltransferase-linked prooxidant effect of glutathione catabolism within the plaque.
Emdin
Michele
M
Unità Operativa Medicina Cardiovascolare, Istituto di Fisiologia Clinica, CNR, Pisa. emdin@ifc.cnr.it
Pompella
Alfonso
A
Passino
Claudio
C
Paolicchi
Aldo
A
D050197:Atherosclerosis / Q000201:enzymology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000201:enzymology*; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; D005723:gamma-Glutamyltransferase