Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models.
Many studies have been carried out in recent years on the pharmacological effects of nigella sativa seeds that have uncovered their antiinflammatory and immunological effects. The objective of this study was to explore the antiinflammatory effects of thymoquinone on arthritis in rat models. Rats with arthritis induced by Freund's incomplete adjuvant were assigned into five groups: group 1: controls 0.9% NaCl (n = 7); group 2: 2.5 mg/kg thymoquinone (n = 7); group 3: 5 mg/kg thymoquinone (n = 7); group 4: Bacilli Chalmette Guerin (BCG) 6 x 10(5) CFU (n = 7); group 5: methotrexate 0.3 mg/kg (n = 7). Signs of inflammation on the claw and radiological signs were searched for and TNF-alpha and IL-1beta were measured. The results of control and other groups were compared. As a result, thymoquinone, confirmed clinically and radiologically, suppressed adjuvant-induced arthritis in rats.
Tekeoglu
Ibrahim
I
Yuzuncu Yil University, Medical School, Department of Rehabilitation and Rheumatology, Maras cad. 65100, Van, Turkey. iteke58@yahoo.com
Dogan
Ali
A
Demiralp
Levent
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000188:drug therapy*; D016227:Benzoquinones / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D031881:Nigella sativa / Q000737:chemistry*; D009822:Oils, Volatile / Q000302:isolation & purification / Q000627:therapeutic use*; D010938:Plant Oils / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D029974:Carum
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D053583:Interleukin-1beta; D009822:Oils, Volatile; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; C104525:caraway oil; C003466:thymoquinone