Biotransformation of physalin H and leishmanicidal activity of its transformed products.
The transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC50 values in the range of 6.03-13.80 microM.
Choudhary
Muhammad Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
Yousuf
Sammer
S
Samreen
Shah
Syed Adnan Ali
SA
Ahmed
Shakil
S
Atta-ur-Rahman
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000378:metabolism* / Q000494:pharmacology; D018320:Leishmania major / Q000187:drug effects*; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D012233:Rhizopus / Q000378:metabolism*; D012632:Secosteroids; D013056:Spectrophotometry, Ultraviolet
D000981:Antiprotozoal Agents; D007783:Lactones; D012632:Secosteroids; C475936:physalin H