title: Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species.
abstract: The antioxidative activity and ameliorative effects on memory impairment by sulfur-containing compounds which occur in Allium vegetables such as onion and garlic were investigated. The antioxidative activities of S-alk(en)yl-L-cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins were examined by using human low-density lipoprotein. It was elucidated that the alk(en)yl substituents and the number of sulfur atoms in the compounds were important for the antioxidative activities. To demonstrate the ameliorative effects on memory impairment, onion extract and synthesized di-n-propyl trisulfide were administered to senescence-accelerated mouse P8. The behavioral experiments showed that onion extract and di-n-propyl trisulfide had highly ameliorative effect of memory impairment. Furthermore, it was found that the hippocampus lipid hydroperoxide in senescence-accelerated mouse P8 was decreased by the administration of di-n-propyl trisulfide. These results suggest that di-n-propyl trisulfide contained in onion ameliorates memory impairment in SAMP8 mouse by its antioxidant effect.
authors.affiliation: Department of Bioscience and Technology, School of Engineering, Hokkaido Tokai University, Sapporo 005-8601, Japan. nishimura@db.htokai.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Ohki
authors.initials: O
authors.lastname: Higuchi
authors.forename: Koutaro
authors.initials: K
authors.lastname: Tateshita
authors.forename: Koji
authors.initials: K
authors.lastname: Tomobe
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Okuma
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000375:Aging / Q000502:physiology; D000490:Allium / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004220:Disulfides / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D019697:Onions / Q000737:chemistry; D010713:Phosphatidylcholines / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D004220:Disulfides; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D010713:Phosphatidylcholines; D010936:Plant Extracts; D013440:Sulfides; C057590:phosphatidylcholine hydroperoxide; C041288:n-propyl disulfide; D003545:Cysteine; C513796:di-n-propyl trisulfide