A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.
[Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
Lu
Bruce Z
BZ
Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., Suite 205, East Leigh Street, Richmond, Virginia 23219, USA. zlu@rdg.boehringer-ingelheim.com
Zhao
Wenyi
W
Wei
Han-Xun
HX
Dufour
Marine
M
Farina
Vittorio
V
Senanayake
Chris H
CH
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
D007211:Indoles; D010165:Palladium