Effect of transcranial magnetic stimulation on oxidative stress induced by 3-nitropropionic acid in cortical synaptosomes.
This study evaluates the effect of transcranial magnetic stimulation (TMS; 60 Hz and 0.7 mT) treatment on 3-nitropropionic acid (20 mg/kg i.p./day for 4 days)-induced oxidative stress in cortical synaptosomes of Wistar rats. The oxidative derangement was confirmed by a high level of lipid peroxidation products and protein carbonyls, together with a decreased in reduced glutathione (GSH) content, catalase and GSH-peroxidase (GSH-Px) activities. Additionally, it was observed a reduction in succinate dehydrogenase (SDH) activity. All changes were partially prevented or reversed by administration of TMS. These results show that TMS reduces oxidative stress in cortical synaptosomes, and suggest that TMS may protect neuronal and maintain synaptic integrity.
Túnez
Isaac
I
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Spain. fm2tufii@uco.es
Montilla
Pedro
P
del Carmen Muñoz
M
M
Medina
Francisco J
FJ
Drucker-Colín
René
R
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology; D008297:Male; D009574:Nitro Compounds / Q000494:pharmacology*; D018384:Oxidative Stress; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects*; D050781:Transcranial Magnetic Stimulation
D015415:Biomarkers; D003292:Convulsants; D009574:Nitro Compounds; D011422:Propionates; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid