COMT genotype and manic symptoms in schizophrenia.
Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.
DeRosse
Pamela
P
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States. pderosse@lij.edu
Funke
Birgit
B
Burdick
Katherine E
KE
Lencz
Todd
T
Goldberg
Terry E
TE
Kane
John M
JM
Kucherlapati
Raju
R
Malhotra
Anil K
AK
D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*; D012720:Severity of Illness Index
D002394:Catechol O-Methyltransferase