title: Biotransformations of 20-hydroxyecdysone and analogues by Curvularia lunata NRRL 2178.
abstract: 20-Hydroxyecdysone, the arthropod moulting hormone, was biotransformed by the fungus Curvularia lunata NRRL 2178 to the rare ecdysteroid, 2-dehydro-3-epi-20-hydroxyecdysone, and the novel 3alpha,9alpha-cyclo ecdysteroid analogue, (20R,22R)-3beta,14alpha,20,22,25-pentahydroxy-3alpha,9alpha-cyclo-5beta-cholest-7-en-2,6-dione in 14 and 44% yields, respectively. Ponasterone A and pterosterone were similarly biotransformed to the corresponding 2-dehydro-3-epi- and 3alpha,9alpha-cyclo-analogues.
authors.affiliation: Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
authors.forename: Chatchawan
authors.initials: C
authors.lastname: Changtam
authors.forename: Oratai
authors.initials: O
authors.lastname: Sukcharoen
authors.forename: Boon-Ek
authors.initials: BE
authors.lastname: Yingyongnarongkul
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D001711:Biotransformation; D003470:Culture Media; D004441:Ecdysterone / Q000493:pharmacokinetics*; D005658:Fungi / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D003470:Culture Media; D004441:Ecdysterone