Improving depression care in patients with diabetes and multiple complications.
BACKGROUND
Depression is common in patients with diabetes, but it is often inadequately treated within primary care. Competing clinical demands and treatment resistance may make it especially difficult to improve depressive symptoms in patients with diabetes who have multiple complications.


OBJECTIVE
To determine whether a collaborative care intervention for depression would be as effective in patients with diabetes who had 2 or more complications as in patients with diabetes who had fewer complications.


METHODS
The Pathways Study was a randomized control trial comparing collaborative care case management for depression and usual primary care. This secondary analysis compared outcomes in patients with 2 or more complications to patients with fewer complications.


METHODS
Three hundred and twenty-nine patients with diabetes and comorbid depression were recruited through primary care clinics of a large prepaid health plan.


METHODS
Depression was assessed at baseline, 3, 6, and 12 months with the 20-item depression scale from the Hopkins Symptom Checklist. Diabetes complications were determined from automated patient records.


RESULTS
The Pathways collaborative care intervention was significantly more successful at reducing depressive symptoms than usual primary care in patients with diabetes who had 2 or more complications. Patients with fewer than 2 complications experienced similar reductions in depressive symptoms in both intervention and usual care.


CONCLUSIONS
Patients with depression and diabetes who have multiple complications may benefit most from collaborative care for depression. These findings suggest that with appropriate intervention depression can be successfully treated in patients with diabetes who have the highest severity of medical problems.
Kinder
Leslie S
LS
Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA. lskinder@stanfordalumni.org
Katon
Wayne J
WJ
Ludman
Evette
E
Russo
Joan
J
Simon
Greg
G
Lin
Elizabeth H B
EH
Ciechanowski
Paul
P
Von Korff
Michael
M
Young
Bessie
B
D000328:Adult; D000368:Aged; D003299:Cooperative Behavior; D003866:Depressive Disorder / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales