title: IL-6 promoter polymorphism -174 is associated with new-onset diabetes after transplantation.
abstract: New-onset diabetes after transplantation (NODAT) is a serious complication of transplantation. This study tested whether IL-6 production capacity may influence the development of NODAT in two different groups of patients. The occurrence of NODAT was analyzed with respect to IL-6 gene promoter polymorphism at position -174 (G-->C) and other relevant risk factors retrospectively in 217 renal transplant recipients and prospectively in 132. A linear increase in both circulating IL-6 (P = 0.09) and C-reactive protein (an indicator of basal IL-6 secretion; P = 0.03) concentrations from the CC genotype to the GG genotype was observed. In the multivariate model, the CC genotype was associated with a decreased risk for NODAT compared with the GG genotype in the two cohorts. Homeostasis Model Assessment for Insulin Resistance also revealed lesser insulin sensitivity in the GG carriers than in the CC carriers (2.15 +/- 2 versus 1.32 +/- 1.03; P = 0.03). Subgroup analysis showed that the influence of IL-6 gene promoter polymorphism on the development of NODAT was restricted mostly to overweight patients. These results highly suggest that IL-6 production capacity influences the development of NODAT and that diabetes-inducing drug administration should be limited in overweight patients who carry the GG genotype.
authors.affiliation: INSERM, U645, University Besançon, and IFR133, Besançon, France.
authors.forename: Jamal
authors.initials: J
authors.lastname: Bamoulid
authors.forename: Cécile
authors.initials: C
authors.lastname: Courivaud
authors.forename: Marina
authors.initials: M
authors.lastname: Deschamps
authors.forename: Patricia
authors.initials: P
authors.lastname: Mercier
authors.forename: Christophe
authors.initials: C
authors.lastname: Ferrand
authors.forename: Alfred
authors.initials: A
authors.lastname: Penfornis
authors.forename: Pierre
authors.initials: P
authors.lastname: Tiberghien
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Chalopin
authors.forename: Philippe
authors.initials: P
authors.lastname: Saas
authors.forename: Didier
authors.initials: D
authors.lastname: Ducloux
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000097:blood; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007328:Insulin; D015850:Interleukin-6; D002097:C-Reactive Protein