title: Flow modulation comprehensive two-dimensional gas chromatography-mass spectrometry with a supersonic molecular beam.
abstract: A new approach of flow modulation comprehensive two-dimensional gas chromatography-mass spectrometry (GC x GC-MS) with supersonic molecular beam (SMB) and a quadrupole mass analyzer is presented. Flow modulation uniquely enables GC x GC-MS to be achieved even with the limited scan speed of quadrupole MS, and its 20 ml/min column flow rate is handled, splitless, by the SMB interface. Flow modulation GC x GC-SMB-MS shares all the major benefits of GC x GC and combines them with GC-MS including: (a) increased GC separation capability; (b) improved sensitivity via narrower GC peaks; (c) improved sensitivity through reduced matrix interference and chemical noise; (d) polarity and functional group sample information via the order of elution from the second polar column. In addition, GC x GC-SMB-MS is uniquely characterized by the features of GC-MS with SMB of enhanced and trustworthy molecular ion plus isotope abundance analysis (IAA) for improved sample identification and fast fly-through ion source response time. The combination of flow modulation GC x GC with GC-MS with SMB (supersonic GC-MS) was explored with complex matrices such as diesel fuel analysis and pesticide analysis in agricultural products.
authors.affiliation: School of Chemistry, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Kochman
authors.forename: Alexander
authors.initials: A
authors.lastname: Gordin
authors.forename: Tal
authors.initials: T
authors.lastname: Alon
authors.forename: Aviv
authors.initials: A
authors.lastname: Amirav
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D028526:Coriandrum / Q000737:chemistry; D003976:Diazinon / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D005742:Gasoline / Q000032:analysis; D009946:Organothiophosphorus Compounds / Q000032:analysis; D010575:Pesticides / Q000032:analysis; D015203:Reproducibility of Results
chemical_list: D004785:Environmental Pollutants; D005742:Gasoline; D009946:Organothiophosphorus Compounds; D010575:Pesticides; C005896:thionazin; D003976:Diazinon