title: Assessment of shunt volumes in children with ventricular septal defects: comparative quantification of MR flow measurements and invasive oximetry.
abstract: The aim of this study was to compare the results of magnetic resonance based shunt volume measurements with the results of the invasive method by the principle of Fick. In 14 children (median age: 16.5 months) with ventricular septal defects the shunt volume was quantified by magnetic resonance flow measurements under spontaneous breathing conditions as well as with invasive angiography during one sedation. A good correlation between both methods was observed (r(2) = 0.8, p <0.0001, CI(95%) = 0.62-1.22). A tendency towards higher values in the noninvasive technique was found in the Bland-Altman plot (bias = 3.79). Magnetic resonance based shunt measurements are a reliable alternative to the invasive shunt measurement by cardiac catheterization.
authors.affiliation: Department of Pediatric Cardiology, Johann Wolfgang Goethe University, Hospital, Frankfurt/M, Germany.
authors.forename: Anoosh
authors.initials: A
authors.lastname: Esmaeili
authors.forename: Rene
authors.initials: R
authors.lastname: Höhn
authors.forename: Arne
authors.initials: A
authors.lastname: Koch
authors.forename: Thomas Josef
authors.initials: TJ
authors.lastname: Vogl
authors.forename: Roland
authors.initials: R
authors.lastname: Hofstetter
authors.forename: Nasreddin
authors.initials: N
authors.lastname: Abolmaali
mesh_terms: D000293:Adolescent; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003326:Coronary Circulation / Q000502:physiology; D006345:Heart Septal Defects, Ventricular / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010092:Oximetry; D011652:Pulmonary Circulation / Q000502:physiology; D015203:Reproducibility of Results