IL-7 drives T cell-mediated bone loss following ovariectomy.
Ovariectomy-induced bone loss stems in large measure from a realignment of adaptive immune responses leading to the activation and expansion of tumor necrosis factor (TNF)-producing T cells. The mechanisms driving this T cell expansion are complex but we have recently reported that the pro-osteoclastogenic cytokine interleukin (IL)-7 plays a critical role in this process. The mechanisms of IL-7 action are intricate and poorly defined. We present herein an overview of our current understanding of IL-7 action on bone turnover and the role of IL-7 in ovariectomy-induced bone loss.
Robbie-Ryan
Michaela
M
Division of Endocrinology & Metabolism & Lipids, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322-0001, USA.
Pacifici
Roberto
R
Weitzmann
M Neale
MN
D000818:Animals; D001862:Bone Resorption / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D015851:Interleukin-7 / Q000494:pharmacology*; D010006:Osteoblasts / Q000276:immunology; D010010:Osteoclasts / Q000276:immunology; D010052:Ovariectomy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D015851:Interleukin-7