Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR.
Estradiol (E2) and estrogen receptor (ER) signaling have been implicated in the development and progression of several cancers. Emerging evidence suggests that the status of ER coregulators in tumor cells plays an important role in hormonal responsiveness and tumor progression. Proline, glutamic acid, and leucine-rich protein-1 (PELP1/MNAR)-a novel ER coactivator that plays an essential role in the ER's actions and its expression-is deregulated in several hormonal responsive cancers. The precise function of PELP1/MNAR in cancer progression remains unclear, but PELP1 appears to function as a scaffolding protein, coupling ER with several proteins that are implicated in oncogenesis. Emerging evidence suggests that PELP1/MNAR increases E2-mediated cell proliferation and participates in E2-mediated tumorigenesis and metastasis.
Rajhans
Rajib
R
Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl drive, Mail code 7836, San Antonio, TX 78229-3900, USA.
Vadlamudi
Ratna K
RK
D001943:Breast Neoplasms / Q000235:genetics / Q000503:physiopathology; D002453:Cell Cycle; D002455:Cell Division; D056970:Co-Repressor Proteins; D004958:Estradiol / Q000502:physiology; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009857:Oncogenes / Q000502:physiology; D012326:RNA Splicing; D011960:Receptors, Estrogen / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors
D056970:Co-Repressor Proteins; C438485:PELP1 protein, human; D011960:Receptors, Estrogen; D015534:Trans-Activators; D014157:Transcription Factors; D004958:Estradiol