The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells.
In this issue of Neuron, Jackson et al. show that adult neural stem cells (B cells) express PDGF receptors. Functional analysis of PDGF signaling in these neural progenitors resonates in provocative ways with an older body of literature on PDGF autocrine loops in malignant glioma and with more recent observations on the bHLH transcription factor Olig2.
Kesari
Santosh
S
Program in Neuro Oncology, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.
Stiles
Charles D
CD
D000328:Adult; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology*
D017479:Receptors, Platelet-Derived Growth Factor