Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa.
A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines.
Montalvo
David
D
Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain.
Amade
Philippe
P
Funel-Le Bon
Corinne
C
Fernández
Rogelio
R
Reyes
Fernando
F
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D008395:Martinique; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D004224:Diterpenes