Interrelationship between glucose and fat utilisation during simultaneous IV administration of glucose and lipid emulsion in healthy man.
In order to evaluate the interaction between glucose and fat utilisation during parenteral nutrition, we studied 12 healthy volunteers under three different conditions: While Intralipid infusion does not alter the glucose utilisation, measured by metabolic clearance rate of glucose at an insulin level of about 80 uU/ml (MCR(glu)submax) 11.3 +/- 1 v.s. 11.48 +/- 0.9 ml/kg/min) and the sensitivity index, it decreases glucose utilisation at an insulin level of about 550 uU/ml (MCR(glu)max) (17.8 +/- 1.3 v.s. 15.9 +/- 0.9 ml/kg/min, p < 0.05) suggesting postreceptor alterations in insulin action. Simultaneous administration of Intralipid with glucose and insulin is associated with a smaller increase in serum triglycerides than the infusion of Intralipid alone (2.56 +/- 0.4 v.s. 5.44 +/- 0.5 mmol/lm p < 0.001). We conclude that, when infused at standard rates, Intralipid does not decrease glucose utilisation significantly and, at the same time, its own clearance is enhanced by glucose and insulin.
Pelikánová
T
T
Institute for Clinical and Experimental Medicine, Vídenská 800, 140 00 Prague, Czechoslovakia.
Andel
M
M
Kohout
M
M
Válek
J
J
Kazdová
L
L