title: New lignans from Kadsura coccinea and their nitric oxide inhibitory activities.
abstract: In vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage like cell line RAW 264.7. Further fractionation of the chloroform extract led to the isolation of three new lignans, including two dibenzocyclooctadiene lignans and one arylnaphthalene lignan, together with other three known dibenzocyclooctadiene lignans. This is the first report of NO production inhibitory activity of Kadsura coccinea and first report about the isolation of arylnaphthalene lignan from K. coccinea.
authors.affiliation: Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences; Beijing, PR China.
authors.forename: He-Ran
authors.initials: HR
authors.lastname: Li
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Akihiro
authors.initials: A
authors.lastname: Daikonya
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Xu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002725:Chloroform / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D027343:Rhizome / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D017705:Lignans; D009569:Nitric Oxide; D002725:Chloroform