Hyperoxaluria in women with vulvar vestibulitis syndrome.
OBJECTIVE
To determine whether evaluation and treatment of hyperoxaluria in vulvar vestibulitis syndrome (VVS) is justified.


METHODS
Forty women (mean age, 24.5 years; range, 18-35) diagnosed with VVS at a sex therapy clinic participated. Diagnosis of VVS relied upon Friedrich's criteria: (1) severe vulvar vestibular pain upon touch or attempted vaginal entry, (2) tenderness to pressure localized within the vulvar vestibule, and (3) physical findings confined to vulvar erythema of various degrees. Oxalate was measured in 24-hour urine samples. Women with hyperoxaluria (urine oxalate >50 mg/24 h) were placed on a low-oxalate diet and oral calcium citrate as single therapy and reevaluated 3 months later.


RESULTS
Hyperoxaluria was diagnosed in 7 women (17.5%), of whom 1 demonstrated an objective improvement and could have pain-free vaginal intercourse following treatment, yielding a 2.5% benefit from the evaluation and treatment of hyperoxaluria.


CONCLUSIONS
There is no justification for evaluation and treatment of hyperoxaluria in women with VVS due to its low yield and economic burden.
Greenstein
Alexander
A
Department of Urology and Sex Therapy Clinic, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. surge04@post.tau.ac.il
Militscher
Idan
I
Chen
Juza
J
Matzkin
Haim
H
Lessing
Joseph B
JB
Abramov
Liora
L
D000293:Adolescent; D000328:Adult; D019355:Calcium Citrate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010146:Pain / Q000517:prevention & control; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000150:complications*
D019355:Calcium Citrate