Photothermally induced delayed tissue death.
We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.
Gordon
Jeffrey M
JM
Ben-Gurion University of the Negev, Jacob Blaustein Institutes for Desert Research, Department of Solar Energy & Environmental Physics, Sede Boqer Campus, Israel. jeff@bgu.ac.il
Shaco-Levy
Ruthy
R
Feuermann
Daniel
D
Huleihil
Mahmoud
M
Mizrahi
Solly
S
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D006498:Hepatectomy / Q000379:methods*; D022781:Hepatocytes / Q000166:cytology* / Q000528:radiation effects*; D008099:Liver / Q000166:cytology / Q000528:radiation effects* / Q000601:surgery*; D010789:Phototherapy / Q000379:methods*; D051381:Rats; D013472:Sunlight