title: Characterization of small liver lesions: Added role of MR after MDCT.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the added role of magnetic resonance imaging (MR) in characterizing subcentimeter focal liver lesion(s) detected on multidetector row helical computed tomography (MDCT).
  
  
  METHODS
  A retrospective analysis was performed in 59 noncirrhotic patients with focal subcentimeter liver lesion(s) detected on a 4- or 16-slice MDCT. All patients had a gadolinium enhanced liver MR on 1.5-T systems within 6 weeks after MDCT. Imaging diagnosis was graded on an ordinal scale of 0-5 (0, normal; 1, definitely benign; and 5, definitely malignant). The final diagnosis was established either by histopathology or follow-up imaging for a period of at least 6 months. Receiver operating characteristic analysis was performed to compare the performances of MDCT and MR in characterization of subcentimeter liver lesions.
  
  
  RESULTS
  A total of 178 lesions were detected on MDCT in 59 patients. Of these lesions, 129 (72.5%) lesions were benign and the remaining 49 were malignant. The sensitivity, specificity, positive predictive value, and negative predictive value in differentiation of benign from malignant lesions on MDCT were 81.2%, 77.3%, 60.5%, 90.6 % and on MR were 83.3%, 97.5%, 92.1%, and 94.4 %, respectively. Comparative receiver operating characteristic analysis showed an area under curve for MDCT = 0.76 and MR = 0.95 (P < 0.001).
  
  
  CONCLUSIONS
  Liver MR has significantly higher accuracy for characterization of subcentimeter focal liver lesions discovered on MDCT.
authors.affiliation: Massachusetts General Hospital, Abdominal Imaging and Interventional Radiology, White 270, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Nagaraj-Setty
authors.initials: NS
authors.lastname: Holalkere
authors.forename: Dushyant V
authors.initials: DV
authors.lastname: Sahani
authors.forename: Michael A
authors.initials: MA
authors.lastname: Blake
authors.forename: Elkan F
authors.initials: EF
authors.lastname: Halpern
authors.forename: Peter F
authors.initials: PF
authors.lastname: Hahn
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mueller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed
chemical_list: D003287:Contrast Media; D005682:Gadolinium