title: Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G.
abstract: The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution.
authors.affiliation: CNRS, Unité Mixte de Recherche (UMR) 2472, Institut Fédératif de Recherche (IFR) 115, Virologie Moléculaire et Structurale, 91198, Gif sur Yvette, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roche
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bressanelli
authors.forename: Félix A
authors.initials: FA
authors.lastname: Rey
authors.forename: Yves
authors.initials: Y
authors.lastname: Gaudin
mesh_terms: D000595:Amino Acid Sequence; D003460:Crystallization; D018360:Crystallography, X-Ray; D019143:Evolution, Molecular; D006863:Hydrogen-Ion Concentration; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D011487:Protein Conformation; D017510:Protein Folding; D020836:Protein Structure, Quaternary; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000737:chemistry; D014721:Vesicular stomatitis Indiana virus / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014760:Viral Fusion Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: C028391:G protein, vesicular stomatitis virus; D008562:Membrane Glycoproteins; D021122:Protein Subunits; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins