title: Combined carotid endarterectomy and coronary artery bypass grafting in patients with asymptomatic high-grade stenoses: an analysis of 758 procedures.
abstract: OBJECTIVE
  Surgical treatment of hemodynamically significant carotid artery stenoses has been well documented, especially in the asymptomatic patient. However, in those patients presenting with hemodynamically significant asymptomatic carotid artery disease who are to undergo cardiac surgery, optimal treatment remains controversial. In this study, we analyze our experience with patients who underwent synchronous carotid endarterectomy (CEA) and coronary artery bypass graft procedures (CABG) for hemodynamically significant (>70%) asymptomatic carotid artery stenosis and coronary artery disease (CAD).
  
  
  METHODS
  Demographics and outcomes of all patients undergoing synchronous CEA/CABG for asymptomatic carotid stenosis between April 1980 and January 2005 were reviewed from our vascular registry and patient charts. We included patients who underwent standard patching of their carotid artery and those undergoing eversion CEA. All neurologic events within the first 30 days that persisted >24 hours were considered a stroke. For purposes of comparison, we also reviewed outcomes for patients undergoing synchronous CEA/CABG for symptomatic carotid stenosis.
  
  
  RESULTS
  Asymptomatic carotid artery stenosis (>70%) was the indication in 702 patients (276 women and 426 men) undergoing 758 CEAs. In the asymptomatic group, 22 patients, of which 21 succumbed to cardiac dysfunction, and one died from a hemorrhagic stroke. The overall mortality rate was 3.1%. Seven permanent nonfatal neurologic deficits occurred in this series (1 woman, 6 men). The combined stroke mortality was 4.3%. This compares to a 30-day stroke mortality of 6.1% in 132 symptomatic combined CEA/CABG patients. The difference in stroke mortality in women compared with men was not significant.
  
  
  CONCLUSIONS
  In this experience, patients presenting with hemodynamically significant (>70%) asymptomatic carotid artery stenosis can undergo synchronous CEA/CABG with low morbidity and mortality.
authors.affiliation: Institute for Vascular Health and Disease, Albany Medical College, Albany, NY, USA.
authors.forename: John
authors.initials: J
authors.lastname: Byrne
authors.forename: R Clement
authors.initials: RC
authors.lastname: Darling
authors.forename: Sean P
authors.initials: SP
authors.lastname: Roddy
authors.forename: Manish
authors.initials: M
authors.lastname: Mehta
authors.forename: Philip S K
authors.initials: PS
authors.lastname: Paty
authors.forename: Paul B
authors.initials: PB
authors.lastname: Kreienberg
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Chang
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Ozsvath
authors.forename: Dhiraj M
authors.initials: DM
authors.lastname: Shah
mesh_terms: D000367:Age Factors; D000368:Aged; D016893:Carotid Stenosis / Q000453:epidemiology / Q000601:surgery*; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000453:epidemiology / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009518:New York