title: Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population.
abstract: BACKGROUND
  The association between obesity and cardiovascular disease risk differs across populations. Whether such differences in obesity-related risk factors exist within population groups of the same genetic origin but with differences in lifestyle remains to be determined.
  
  
  OBJECTIVE
  The aim was to analyze whether obesity was associated with the same degree of metabolic disturbances in 2 groups of genetically homogeneous Inuit who were exposed to considerable differences in lifestyle.
  
  
  METHODS
  We studied obesity and cardiovascular disease risk factors in a cross-sectional population survey of 2311 Inuit living in Denmark (n = 995) or Greenland (n = 1316). The participants received an oral-glucose-tolerance test. Blood tests were supplemented by structured interviews and anthropometric and blood pressure measurements.
  
  
  RESULTS
  The trend in the association between obesity and metabolic effects was not significantly different in the Inuit populations, but the values of several risk factors were significantly different. At any given level of obesity, Inuit residents in Greenland had lower blood pressure and lower concentrations of triacylglycerol and postchallenge plasma glucose and insulin than did the Inuit migrants in Denmark. The trend in the association with obesity categories was different only for HDL cholesterol, with higher concentrations observed in women Inuit migrants in Denmark than in women Inuit residents in Greenland.
  
  
  CONCLUSIONS
  The health risk associated with obesity clearly varies within groups of Inuit living in Greenland and Inuit migrants living in Denmark. The findings indicate that lifestyle factors modify the cardiovascular disease risk associated with obesity.
authors.affiliation: Centre for Health Research in Greenland, National Institute of Public Health, Copenhagen, Denmark. mej@niph.dk
authors.forename: Marit E
authors.initials: ME
authors.lastname: Jørgensen
authors.forename: Knut
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: Peter
authors.initials: P
authors.lastname: Bjerregaard
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D004641:Emigration and Immigration; D005247:Feeding Behavior / Q000208:ethnology*; D005260:Female; D005951:Glucose Tolerance Test; D006116:Greenland / Q000453:epidemiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D004930:Inuit / Q000235:genetics; D008019:Life Style; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000208:ethnology; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides