Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds.
A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents.
Hadjipavlou
Christiana
C
Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
Kostakis
Ioannis K
IK
Pouli
Nicole
N
Marakos
Panagiotis
P
Pratsinis
Harris
H
Kletsas
Dimitris
D
D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000235:genetics; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000633:toxicity*; D015394:Molecular Structure; D009564:Nitracrine / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000633:toxicity
D007211:Indoles; D014966:Xanthenes; D009564:Nitracrine; D004247:DNA