title: Vascular smooth muscle cell senescence in atherosclerosis.
abstract: Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.
authors.affiliation: Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gorenne
authors.forename: Mary
authors.initials: M
authors.lastname: Kavurma
authors.forename: Stephen
authors.initials: S
authors.lastname: Scott
authors.forename: Martin
authors.initials: M
authors.lastname: Bennett
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology*; D016615:Telomere / Q000648:ultrastructure; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D001616:beta-Galactosidase