Current advances in local protein synthesis and synaptic plasticity.
Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.
Pfeiffer
Brad E
BE
Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA.
Huber
Kimberly M
KM
D000818:Animals; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D014176:Protein Biosynthesis / Q000502:physiology*; D013569:Synapses / Q000502:physiology*