title: Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study.
abstract: OBJECTIVE
  To identify the risk factors associated with primary open-angle glaucoma (POAG) in the Tajimi Study.
  
  
  METHODS
  Population-based cross-sectional epidemiologic study.
  
  
  METHODS
  One hundred nineteen POAG patients and 2755 controls.
  
  
  METHODS
  Univariate and multivariate comparison of ocular factors and systemic factors between POAG patients and controls.
  
  
  METHODS
  Difference in factors between POAG patients and controls, factors associated with POAG patients, and their odds ratio (OR).
  
  
  RESULTS
  Intraocular pressure (IOP), age, myopia, and history of hypertension differed between POAG patients and controls in univariate analyses. Multivariate analysis with logistic regression with stepwise selection of variables demonstrated that higher IOP (OR, 1.12 [95% confidence interval (CI), 1.04-1.21]), myopia (ORs, 1.85 [95% CI, 1.03-3.31] for low myopia and 2.60 [95% CI, 1.56-4.35] for moderate to high myopia), and older age (OR, 1.06 [95% CI, 1.04-1.08]) were associated with an increased risk of having POAG.
  
  
  CONCLUSIONS
  Although the majority (92%) of POAG patients diagnosed in the Tajimi Study had IOP within the normal range, IOP was still identified as a significant risk factor for POAG. Together with IOP, myopia and age were significant risk factors for having POAG.
authors.affiliation: Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Haruki
authors.initials: H
authors.lastname: Abe
authors.forename: Shiroaki
authors.initials: S
authors.lastname: Shirato
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kuwayama
authors.forename: Hiromu K
authors.initials: HK
authors.lastname: Mishima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Goji
authors.initials: G
authors.lastname: Tomita
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitazawa
mesh_terms: D000367:Age Factors; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D007429:Intraocular Pressure; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications; D016017:Odds Ratio; D012307:Risk Factors; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields