CD1d ligands: the good, the bad, and the ugly.
The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.
Brutkiewicz
Randy R
RR
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
D000276:Adjuvants, Immunologic / Q000378:metabolism / Q000502:physiology; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology* / Q000378:metabolism* / Q000502:physiology; D055610:Antigens, CD1d; D002240:Carbohydrate Sequence; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D014777:Virus Diseases / Q000276:immunology / Q000821:virology
D000276:Adjuvants, Immunologic; D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D008024:Ligands