title: Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.
abstract: BACKGROUND
  Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD.
  
  
  METHODS
  The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs.
  
  
  RESULTS
  No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003).
  
  
  CONCLUSIONS
  The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.
authors.affiliation: Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: P I
authors.initials: PI
authors.lastname: Lin
authors.forename: E R
authors.initials: ER
authors.lastname: Martin
authors.forename: P G
authors.initials: PG
authors.lastname: Bronson
authors.forename: C
authors.initials: C
authors.lastname: Browning-Large
authors.forename: G W
authors.initials: GW
authors.lastname: Small
authors.forename: D E
authors.initials: DE
authors.lastname: Schmechel
authors.forename: K A
authors.initials: KA
authors.lastname: Welsh-Bohmer
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: J R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D002881:Chromosomes, Human, Pair 12; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D005987:Glyceraldehyde-3-Phosphate Dehydrogenases