Concurrent development of Crohn disease and myelodysplastic syndrome in a child: case report and literature review.
A small number of cases of Crohn disease associated with myelodysplastic syndromes or leukemia have been reported in adults in the last 25 years in the English-language medical literature. The authors report a case of a 9-year-old boy who developed Crohn disease and myelodysplastic syndrome concurrently. Analysis of his bone marrow showed a chromosome 20 abnormality. Although chromosome 20 abnormalities have been reported in a minority of these patients, the significance of this association remains unclear at the present time.
Nahas
Sergio Carlos
SC
Department of Gastroenterology-Digestive Surgery Division, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil. caionahas@uol.com.br
Nahas
Caio Sergio Rizkallah
CS
Marques
Carlos Frederico
CF
Borba
Marcelo Rodrigues
MR
Helito
Alfredo Salim
AS
Odoni
Vicente
V
D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology; D001856:Bone Marrow Examination; D002648:Child; D002869:Chromosome Aberrations; D002890:Chromosomes, Human, Pair 20; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics; D018572:Disease-Free Survival; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010198:Pancytopenia / Q000188:drug therapy; D012074:Remission Induction / Q000379:methods