title: [Prognostic significance of PIN and Atypical Small Acinar Proliferation on transrectal ultrasound-guided prostate biopsy].
abstract: OBJECTIVE
  To review the incidence of PIN and Atypical Small Acinar Proliferation (ASAP) on first biopsy, the risk to find cancer on following biopsies and what is the importance given to this findings, analizing how frequently and how long after the initial finding this patients are rebiopsied.
  
  
  METHODS
  We selected 6000 patients who underwent TRUS biopsy between 1994 and 2002. Patients with prior cancer diagnosis were not included. 861 of them underwent more than one biopsy, adding up to a total of 7127 biopsies. A descriptive study has been done including percentages and percentiles for qualitative variables, mean and median for continuous variables.
  
  
  RESULTS
  Incidence of cancer on the first biopsy was 39,1%. PIN and ASAP are stable or slightly increase from 2 and 2,1% respectively on the first biopsy to more than 6% on the fourth and fifth ones. Mean time between biopsies when ASAP or PIN are the initial findings is 180 +/- 221,6 and 264 +/- 213,8 days respectively. Just 42 and 40% of patients with prior PIN or ASAP diagnose are rebiopsied. On subsequent biopsies 45 and 40% of cancers were respectively found.
  
  
  CONCLUSIONS
  Presence of PIN or ASAP implies a higher cancer risk on subsequent biopsies; in spite of that, less than half of them are biopsied again. Performing two more biopsies or an amplified biopsy can find most of the tumors associated.
authors.affiliation: Unidad de Ecografia Urológica, Madrid. rafael.rodriguezpatron@wanadoo.es
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez-Patrón Rodríguez
authors.forename: T
authors.initials: T
authors.lastname: Mayayo Dehesa
authors.forename: F J
authors.initials: FJ
authors.lastname: Burgos Revilla
authors.forename: E
authors.initials: E
authors.lastname: Sanz Mayayo
authors.forename: R
authors.initials: R
authors.lastname: García González
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D002455:Cell Division; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted; D013997:Time Factors; D018084:Ultrasonography, Interventional