title: Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci.
abstract: Viridans streptococci are a major cause of infective endocarditis, and penicillin non-susceptibility is increasing in these organisms. We present the initial reported case of infective endocarditis due to penicillin non-susceptible viridans streptococci successfully treated with ceftriaxone monotherapy. The lack of evidence supporting the recommendations for treatment of endocarditis due to penicillin non-susceptible viridans streptococci is discussed.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, N-1319, BCM-286, 1 Baylor Plaza, Houston, TX 77030, USA. samuels@bcm.tmc.edu
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Shelburne
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Greenberg
authors.forename: Saima
authors.initials: S
authors.lastname: Aslam
authors.forename: David J
authors.initials: DJ
authors.lastname: Tweardy
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010403:Penicillin Resistance; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome; D034363:Viridans Streptococci / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone