Function and molecular mechanism of tumor-targeted peptides for delivering therapeutic genes and chemical drugs.
Tumor-targeted chemo- or gene-therapies is a new form of treatment which provides the benefits of reducing systemic toxicity, increasing the tolerance, and enhancing therapeutic efficacy. This review will discuss the discovery, function, application, and mechanism by which the short peptides (5-9) work for tumor-targeted gene or drug delivery.
Craig
Ryan
R
Department of Comparative Biomedical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, 70803, USA.
Li
Shulin
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage* / Q000378:metabolism*
D000970:Antineoplastic Agents; D010455:Peptides