title: Antimicrobial susceptibility of pathogens isolated from adult patients with uncomplicated community-acquired urinary tract infections in the Russian Federation: two multicentre studies, UTIAP-1 and UTIAP-2.
abstract: In two Russian studies (UTIAP-1 and UTIAP-2) susceptibility to commonly used antimicrobial agents for urinary tract infections (UTI) was determined. 456 urinary isolates were obtained from 588 out-patients with uncomplicated UTI in eight Russian centers during 1998-2001. The most common pathogens were Escherichia coli (85.9%) and Klebsiella pneumoniae (6.0%). Over 90% of the E. coli isolates were susceptible to nitrofurantoin (95.7%), cefuroxime (96.4%) and ciprofloxacin (95.5%). Co-amoxiclav, nalidixic acid and pipemidic acid were less active -84.4%, 93.1% and 93.9% susceptibility stains correspondingly. In contrast, 37.1% of the E. coli isolates were resistant to ampicillin, 22.9% to trimethoprim, 21% to co-trimoxazole. Susceptibility patterns of uropathogens vary between geographical regions of Russia.
authors.affiliation: Institute of Antimicrobial Chemotherapy, State Medical Academy, Smolensk, Russian Federation.
authors.forename: Leonid S
authors.initials: LS
authors.lastname: Stratchounski
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Rafalski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011446:Prospective Studies; D012426:Russia / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents