Tumor angiogenesis in gastric cancer.
Growth of solid tumors, including gastric cancer, and the formation of metastasis depend on the induction of new blood vessels; in tumors, angiogenesis is uncontrolled and immature. This is a complex process, depending on a great variety of angiogenic factors, one of the most important being the vascular endothelial growth factor. In order to suppress the tumor development and the occurrence of metastasis, clinical trials have been developed with angiogenesis inhibitors, many of them with encouraging results. Further research is needed in regard to the idea of combined antiangiogenic therapy with conventional chemotherapy, or even immune or genetic therapies, in order to increase treatment efficiency and to suppress side effects.
Lazăr
Daniela
D
Clinic of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara. gene_lazar@yahoo.com
Raica
M
M
Sporea
I
I
Tăban
Sorina
S
Goldiş
A
A
Cornianu
Marioara
M
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002986:Clinical Trials as Topic; D051546:Cyclooxygenase 2 / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008407:Mast Cells / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D011230:Precancerous Conditions / Q000098:blood supply / Q000378:metabolism; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D019700:Thrombospondin 1 / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
D020533:Angiogenesis Inhibitors; D008565:Membrane Proteins; D019700:Thrombospondin 1; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human