title: Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series.
abstract: OBJECTIVE
  The aim of the present case series was to evaluate the healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (NHA) or a bovine-derived xenograft in combination with a collagen membrane (BDX+BG).
  
  
  METHODS
  Twenty-two patients having moderate peri-implantitis (n=22 intrabony defects) were randomly treated with (i) access flap surgery (AFS) and the application of NHA, or with AFS and the application of BDX+BG. Clinical parameters were recorded at baseline and after 6 months of non-submerged healing.
  
  
  RESULTS
  Post-operative wound healing revealed that NHA compromized initial adhesion of the mucoperiosteal flaps in all patients. At 6 months after therapy, NHA showed a reduction in the mean PD from 7.0+/-0.6 to 4.9+/-0.6 mm and a change in the mean clinical attachment loss (CAL) from 7.5+/-0.8 to 5.7+/-1.0 mm. In the BDX+BC group, the mean PD was reduced from 7.1+/-0.8 to 4.5+/-0.7 mm and the mean CAL changed from 7.5+/-1.0 to 5.2+/-0.8 mm.
  
  
  CONCLUSIONS
  Within the limits of the present case series, it can be concluded that at 6 months after surgery both therapies resulted in clinically important PD reductions and CAL gains.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. info@frank-schwarz.de
authors.forename: F
authors.initials: F
authors.lastname: Schwarz
authors.forename: K
authors.initials: K
authors.lastname: Bieling
authors.forename: T
authors.initials: T
authors.lastname: Latz
authors.forename: E
authors.initials: E
authors.lastname: Nuesry
authors.forename: J
authors.initials: J
authors.lastname: Becker
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002417:Cattle; D003094:Collagen; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D017886:Durapatite; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals; D010512:Periodontal Index; D010518:Periodontitis / Q000209:etiology* / Q000601:surgery; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen; D017886:Durapatite