Differential atrial versus ventricular ANKRD1 gene expression is oppositely regulated at diastolic heart failure.
Diastolic heart failure (DHF) was produced in 6-day-old piglets by intravenous administration of Doxorubicin, and ANKRD1 protein and mRNA levels were determined in atrial (A) and ventricular (V) chambers of failing vs control hearts. In controls, ANKRD1 showed a left-right (L-R) asymmetric distribution with protein levels 2-fold higher in the LA as compared to the RA, and 8-fold higher in the LV than the RV. In failing hearts, ANKRD1 levels were augmented about 2-fold in each ventricle but equally reduced in both atria as compared to controls. ANKRD1 downregulation in atria is discussed as a process associated with advanced DHF.
Torrado
Mario
M
Developmental Biology Group, Institute of Health Sciences, University of La Coruña, La Coruña, Spain.
Nespereira
Beatriz
B
Bouzamayor
Yolanda
Y
Centeno
Alberto
A
López
Eduardo
E
Mikhailov
Alexander T
AT
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000633:toxicity; D003971:Diastole; D015536:Down-Regulation / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000633:toxicity; D006325:Heart Atria / Q000378:metabolism / Q000473:pathology; D006333:Heart Failure / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D009124:Muscle Proteins / Q000096:biosynthesis*; D009928:Organ Specificity; D013552:Swine
D000903:Antibiotics, Antineoplastic; D009124:Muscle Proteins; D004317:Doxorubicin