Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of FcRn in the epithelium is shown here to be associated with secretion of IgG into the lumen that allows for defense against an epithelium-associated pathogen (Citrobacter rodentium). This pathway of host resistance to a bacterial pathogen as mediated by FcRn involves retrieval of bacterial antigens from the lumen and initiation of adaptive immune responses in regional lymphoid structures. Epithelial-associated FcRn, through its ability to secrete and absorb IgG, may thus integrate luminal antigen encounters with systemic immune compartments and as such provide essential host defense and immunoregulatory functions at the mucosal surfaces.
Yoshida
Masaru
M
Department of Medicine, Brigham and Women's Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kobayashi
Kanna
K
Kuo
Timothy T
TT
Bry
Lynn
L
Glickman
Jonathan N
JN
Claypool
Steven M
SM
Kaser
Arthur
A
Nagaishi
Takashi
T
Higgins
Darren E
DE
Mizoguchi
Emiko
E
Wakatsuki
Yoshio
Y
Roopenian
Derry C
DC
Mizoguchi
Atsushi
A
Lencer
Wayne I
WI
Blumberg
Richard S
RS
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D018928:Immunity, Mucosal; D007074:Immunoglobulin G / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016133:Polymerase Chain Reaction; D011961:Receptors, Fc / Q000235:genetics / Q000502:physiology*; D017452:Receptors, IgG / Q000235:genetics / Q000502:physiology*
C485701:Fcgr1 protein, mouse; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG