title: The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.
abstract: Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. The authors examined the blood pressure-lowering effect and safety of CGA in patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n = 28) were randomized to receive treatment with CGA (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine blood test, hematochemistry, urinalysis, and subjective symptoms were recorded throughout the study. In the CGA group, but not the placebo group, blood pressure (systolic and diastolic) decreased significantly during the ingestion period. There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension.
authors.affiliation: Health Care Products Laboratories, Kao Corporation, Tokyo, Japan. watanabe.takuya@kao.co.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Arai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mitsui
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kusaura
authors.forename: Wataru
authors.initials: W
authors.lastname: Okawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kajihara
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D002726:Chlorogenic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D040503:Coffea; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations; D012639:Seeds; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D028321:Plant Preparations; D002726:Chlorogenic Acid