title: Evaluation and quantification of morphological characteristics associated to hepatitis C virus infection: comparative study with hepatitis B.
abstract: Hepatic histological features described in hepatitis C virus (HCV) infection include bile duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. We have examined the frequency of these lesions in 189 liver biopsy specimens, to distinguish HCV from hepatitis B infection. We have analyzed a set of three features of tures more likely to be seen in HCV than in HBV infection: lymphoid follicles and/or aggregates (68%/20%), bile duct damage (44%/22%) and large-droplet fat (77%/64%). A fourth lesion, Mallory body-like material, was seen more frequently in HCV than HBV (25%/5%). These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.
authors.affiliation: Department of Pathology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara. sorinataban@yahoo.com
authors.forename: Marioara
authors.initials: M
authors.lastname: Cornianu
authors.forename: Alis
authors.initials: A
authors.lastname: Dema
authors.forename: Sorina
authors.initials: S
authors.lastname: Tăban
authors.forename: Daniela
authors.initials: D
authors.lastname: Lazăr
authors.forename: Elena
authors.initials: E
authors.lastname: Lazăr
authors.forename: Corina
authors.initials: C
authors.lastname: Vernic
mesh_terms: D001652:Bile Ducts / Q000473:pathology; D001706:Biopsy; D019694:Hepatitis B, Chronic / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology