title: Moderate magnesium-restricted diet affects bone formation and bone resorption in rats.
abstract: This study investigated the effects of moderate magnesium (Mg)-restricted diet on bone formation and bone resorption in rats. Weanling Wistar strain rats were randomly divided into three dietary groups of 6 rats each and fed their respective diets; a control diet containing 0.05% Mg (C), a half Mg diet containing 0.025% Mg (1/2Mg), or a one-fifth Mg diet containing 0.01% Mg (1/5Mg), for 21 days. Serum osteocalcin level was significantly reduced with decreasing dietary Mg level. Urinary excretion of C-terminal telopeptide of type 1 collagen was significantly higher in the 1/5Mg group than in the C group. Serum insulin-like growth factor-1 (IGF-1) level was significantly lower in the 1/2Mg and 1/5Mg groups than in the C group. Serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL) level was significantly higher in the 1/2Mg and 1/5Mg groups than in the C group. These results showed that a moderate Mg-restricted diet induced a decrease in bone formation and an increase in bone resorption. Furthermore, these changes of bone formation and bone resorption might be caused by serum IGF-1 and sRANKL levels, respectively.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
authors.forename: S I
authors.initials: SI
authors.lastname: Katsumata
authors.forename: H
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: R
authors.initials: R
authors.lastname: Tsuboi
authors.forename: M
authors.initials: M
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D001862:Bone Resorption; D004032:Diet; D004435:Eating; D005243:Feces / Q000737:chemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000737:chemistry; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D053245:RANK Ligand / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D053245:RANK Ligand; D007334:Insulin-Like Growth Factor I; D008274:Magnesium