Effectiveness of paroxetine in the treatment of obsessive-compulsive disorders.
Clomipramine ushered in a new age of pharmacotherapy for obsessive-compulsive disorders, and it also facilitated our understanding of the biological aspects of obsessive-compulsive disorder, focusing on the serotonergic systems. The introduction of selective serotonin reuptake inhibitors has led to great progress in the pharmacological study of obsessive-compulsive disorder based on the serotonin hypothesis. Currently, selective serotonin reuptake inhibitors are positioned as a first-line drug of obsessive-compulsive disorder pharmacotherapy in the various guidelines and algorithms. Among six different selective serotonin reuptake inhibitors (paroxetine, sertraline, fluoxetine, fluvoxamine, citalopram, escitalopram) that are available worldwide, paroxetine has the broadest treatment spectrum and promises great benefits not only for obsessive-compulsive disorder patients, but also for those with comorbid depression and/or various kinds of anxiety disorders. This paper presents several clinical trials of paroxetine carried out, and discusses and reviews the therapeutic strategies for obsessive-compulsive disorder.
Kamijima
Kunitoshi
K
International University of Health and Welfare, Department of Health and Social Service, 2600-1, Kitakanemaru, Otawara-city, Tochigi, 324-8501, Japan. kamijima@kitanet.ne.jp
Aoki
Mayumi
M
D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000517:prevention & control*; D017374:Paroxetine / Q000008:administration & dosage* / Q000009:adverse effects*; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine