Azithromycin failure in Mycoplasma genitalium urethritis.
We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.
Bradshaw
Catriona S
CS
Alfred Hospital, Victoria, Australia. cbradshaw@mshc.org.au
Jensen
Jorgen S
JS
Tabrizi
Sepehr N
SN
Read
Timothy R H
TR
Garland
Suzanne M
SM
Hopkins
Carol A
CA
Moss
Lorna M
LM
Fairley
Christopher K
CK
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D009175:Mycoplasma Infections / Q000188:drug therapy* / Q000382:microbiology*; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D011804:Quinolines / Q000627:therapeutic use; D017211:Treatment Failure; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D017963:Azithromycin; D000077266:Moxifloxacin