title: [Current situation of researches on the molecule mechanism of hormone refractory prostate cancer].
abstract: Most cases of prostate cancer become hormone refractory after 12 to 18 months of androgen deprivation therapy. The etiology of the disease is thought to be multifactorial, associated with genetic, dietary, and environmental factors. The article reviews the current situation of researches at home and abroad on the molecule mechanism of hormone refractory. It expounds the influence of the androgen receptor and its genetic mutation, apoptosis and the gene changes of p53, p21, EphB2 on prostate cancer. It is hoped to be of some directive value for the studies of prostate cancer.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Second Medical University, Shanghai Institute of Andrology, Shanghai 200001, China.
authors.forename: Nian-qin
authors.initials: NQ
authors.lastname: Yang
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Wang
mesh_terms: D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D015689:Oncogene Protein p21(ras) / Q000235:genetics; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D051381:Rats; D036183:Receptor, EphB2 / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics*
chemical_list: D000728:Androgens; D011944:Receptors, Androgen; D036183:Receptor, EphB2; D015689:Oncogene Protein p21(ras)