title: Intersubject variability of risk from perchlorate in community water supplies.
abstract: This article is a brief review and summary of the estimated incremental risks (increases in hazard quotient or decreases in thyroid uptake of iodine) to pregnant women (and hence their fetuses) associated with perchlorate exposure in community water supplies (CWSs) . The analysis draws on the recent health effects review published in 2005 by the National Research Council (NRC) . We focus on the potential level of risk borne by the NRC-identified most sensitive subpopulation (pregnant women and hence their fetuses) . Other members of the population should be at a level of risk below that calculated here, and so protection of the sensitive subpopulation would protect the general public health. The analysis examines the intersubject distribution of risks to this sensitive subpopulation at various potential drinking water concentrations of perchlorate and also draws on estimates of the national occurrence of perchlorate in U.S. CWSs to estimate the variability of risks under defined regulatory scenarios. Results suggest that maximum contaminant levels (MCLs) of up to 24.5 microg/L should pose little or no incremental risk to the large majority of individuals in the most sensitive subpopulations exposed in the United States at current levels of perchlorate in water. The protectiveness of an MCL of 24.5 microg/L depends, however, on whether the study subjects in the health effects data used here may be assumed to have been exposed to background (non-drinking water) contributions of perchlorate.
authors.affiliation: Department of Environmental Sciences and Engineering and Carolina Environmental Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. douglas_crawford-brown@unc.edu
authors.forename: Doug
authors.initials: D
authors.lastname: Crawford-Brown
authors.forename: Bob
authors.initials: B
authors.lastname: Raucher
authors.forename: Megan
authors.initials: M
authors.lastname: Harrod
mesh_terms: D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007455:Iodine / Q000494:pharmacology; D010472:Perchlorates / Q000737:chemistry* / Q000494:pharmacology*; D011247:Pregnancy; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000187:drug effects; D014881:Water Supply
chemical_list: D010472:Perchlorates; D007455:Iodine