Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth.
BACKGROUND
Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated.


METHODS
Forty-four surgically-resected human lung cancer tissues were xenotransplanted into SCID mice. Their blood was collected and the volume of the transplanted tumors was measured regularly. The correlations between the IgG titer in the sera and the growth of the transplanted tumors according to the clinicopathological variables were examined.


RESULTS
Human IgG production from TIB was observed in the all xenotransplanted mice. Twenty-seven out of the 44 tumors regressed gradually. The average serum human IgG level of the tumor regressors (n = 10) was significantly higher than that of the progressors (n = 9) in squamous cell carcinoma (p = 0.02), while there was no significant difference in the other histological groups.


CONCLUSIONS
IgG produced by TIB might play a crucial role in preventing tumor growth in squamous cell carcinoma.
Mizukami
Makiko
M
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan. macky@med.uoeh-u.ac.jp
Hanagiri
Takeshi
T
Shigematsu
Yoshiki
Y
Baba
Tetsuro
T
Fukuyama
Takashi
T
Nagata
Yoshika
Y
So
Tetsuya
T
Ichiki
Yoshinobu
Y
Sugaya
Masakazu
M
Yasuda
Manabu
M
So
Tomoko
T
Takenoyama
Mitsuhiro
M
Sugio
Kenji
K
Yasumoto
Kosei
K
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D048708:Cell Growth Processes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D007074:Immunoglobulin G