title: Anterior thoracic spine reconstruction using a titanium mesh cage and pedicled rib flap.
abstract: METHODS
  A retrospective clinical study.
  
  
  OBJECTIVE
  To evaluate the safety and efficacy of using an integrated titanium mesh cage and pedicled rib flap for thoracic spine reconstruction in patients at high risk of pseudarthrosis.
  
  
  BACKGROUND
  A variety of materials are available for interbody thoracic reconstruction; however, the optimal treatment of patients at high risk of pseudarthrosis remains a challenging problem. Free or pedicled bone flaps have been shown to be highly effective in terms of promoting fusion and titanium mesh cages provide excellent structural support.
  
  
  METHODS
  Eleven patients who underwent anterior thoracic corpectomy and spinal reconstruction using an integrated titanium mesh cage and pedicled rib flap were analyzed with a mean follow-up of 37 months (range, 25-55 months). The etiology of spinal disease was infection in 7 (64%) patients and tumor in the remaining 4 (36%) patients. Seven (64%) patients were treated with only an anterior approach while the remaining 4 (36%) patients underwent circumferential spinal reconstruction.
  
  
  RESULTS
  All patients demonstrated clinical and radiographic evidence of spinal fusion at the time of follow-up. All patients had stable or improved Frankel grades after surgery. There was a mean kyphosis correction of 7 degrees for both the focal and regional thoracic kyphosis. There were three significant postoperative complications: bilateral pleural effusion, gram-negative bacteremia, and transient right lower extremity weakness requiring reoperation and pedicle screw revision. Two patients died after surgery: one from aneurysmal subarachnoid hemorrhage and the other from complications of breast cancer.
  
  
  CONCLUSIONS
  The use of an integrated rib flap and titanium mesh cage construct appears to be a safe and effective means of providing immediate and substantial anterior column support as well as achieving arthrodesis in challenging fusion candidates.
authors.affiliation: Department of Neurological Surgery and Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, McGaw Medical Center, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: O'Shaughnessy
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Ondra
authors.forename: Aruna
authors.initials: A
authors.lastname: Ganju
authors.forename: Hakim K
authors.initials: HK
authors.lastname: Said
authors.forename: Julius W
authors.initials: JW
authors.lastname: Few
authors.forename: John C
authors.initials: JC
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000209:etiology; D001424:Bacterial Infections / Q000150:complications; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000209:etiology; D006801:Humans; D016268:Internal Fixators; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D010996:Pleural Effusion / Q000209:etiology; D011859:Radiography; D012189:Retrospective Studies; D012272:Ribs; D013122:Spinal Diseases / Q000209:etiology / Q000601:surgery*; D013123:Spinal Fusion / Q000009:adverse effects; D013125:Spinal Neoplasms / Q000601:surgery; D013524:Surgical Flaps; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome
chemical_list: D014025:Titanium