Solution equilibrium characterization of insulin-mimetic Zn(II) complexes.
Solution speciation (stoichiometry and stability constants) of the insulin mimetic Zn(II) complexes of several bidentate ligands with (O,O), (N,O) or (S,O) coordination modes have been determined by pH-metry at 25 degrees Celsius and I=0.2M (KCl). All ligands were found to coordinate in a bidentate way forming mono, bis and tris complexes, besides a mixed hydroxo bis complex ZnL(2)(OH) detected in the slightly basic pH range together with the tris complex. Relationships between the stability data, lipophilicity of the complexes and earlier biological data are evaluated. The validity of the linear free energy relationships (LFER) between the proton and Zn(II) complexes and also between the VO(IV) and Zn(II) complexes is tested.
Jakusch
T
T
Bioinorganic Chemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, P.O. Box 440, H-6701 Szeged, Hungary.
Gajda-Schrantz
K
K
Adachi
Y
Y
Sakurai
H
H
Kiss
T
T
Horváth
L
L
D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D007328:Insulin; D009942:Organometallic Compounds; D015032:Zinc