title: [Liver regenerative potential of the lake frog Rana ridibunda after partial hepatectomy].
abstract: A histomorphological study of the regenerating liver of Rana ridibunda, within 2 months after partial hepatectomy, shows that regenerative processes on the wound surface are slowly proceeding. Processes of reticular fiber reconstruction occurred in the composition of the basal membrane of liver sinusoids. A cytophotometric study shows that glandular cells in R. ridibunda liver are commonly tetraploid. The post-traumatic regeneration of the liver after partial hepatectomy involves activation of DNA synthesis in hepatocytes, leading to increase in their ploidy. Within the 1st month of regeneration, the mitotic index of hepatocytes substantially increased. Regeneration of glandular parenchyma of the liver is accompanied by a quantitative increase in binucleate hepatocytes, which is most highly expressed within 5-20 days after partial hepatectomy.
authors.forename: A F
authors.initials: AF
authors.lastname: Karapetian
authors.forename: K A
authors.initials: KA
authors.lastname: Dzhivanian
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003592:Cytophotometry; D006498:Hepatectomy; D022781:Hepatocytes / Q000166:cytology; D008099:Liver / Q000166:cytology / Q000502:physiology; D008115:Liver Regeneration; D008940:Mitotic Index; D011003:Ploidies; D011895:Rana ridibunda / Q000502:physiology*; D012155:Reticulin; D013997:Time Factors
chemical_list: D012155:Reticulin