Nuclear protein kinase C-delta: a possible check-point of cell cycle progression.
Protein kinase Cs (PKCs) belong to a serine/threonine kinase family, ubiquitously expressed and claimed to be involved in physiological processes including apoptosis, cell growth and differentiation. The question of the subcellular localization and activity of PKCs remains to be clarified. Here we report that nuclear PKC-delta cooperates to regulate the S-G2/M phase transition of cell cycle, apparently being associated to chromosome condensation and alignment on the metaphase plate.
Marchisio
M
M
Cell Signalling Unit at the Department of Biomorphology, University of Chieti-Pescara, Italy.
Bertagnolo
V
V
Lanuti
P
P
Gaspari
A R
AR
Paludi
M
M
Ciccocioppo
F
F
Ercolino
E
E
Bascelli
A
A
Cataldi
A
A
Miscia
S
S
D002453:Cell Cycle / Q000502:physiology*; D002467:Cell Nucleus / Q000201:enzymology*; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D007150:Immunohistochemistry; D019169:Jurkat Cells; D051745:Protein Kinase C-delta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism
D004247:DNA; D051745:Protein Kinase C-delta