New alkaloids from Phoebe grandis (Nees) Merr.
The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 microg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.
Awang
Khalijah
K
Chemistry Department, University Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my
Mukhtar
Mat Ropi
MR
Hadi
A Hamid A
AH
Litaudon
Marc
M
Latip
Jalifah
J
Abdullah
Noor Rain
NR
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000254:growth & development; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D000962:Antimalarials