Catalyst recycling via hydrogen-bonding-based affinity tags.
[Structure: see text] A novel procedure for catalyst recycling is described. Copper(I)-based catalysts, equipped with an affinity tag, are isolated from crude reaction mixtures on the basis of quadruple hydrogen-bonding interactions using a resin functionalized with complementary affinity tags. Recycled catalysts were successfully used to catalyze a tandem Sonogashira coupling/5-endo-dig cyclization and a Cu-catalyzed [3+2] Huisgen cycloaddition reaction in high yields.
Gruijters
Bas W T
BW
Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, NL-6525 ED Nijmegen, The Netherlands.
Broeren
Maarten A C
MA
van Delft
Floris L
FL
Sijbesma
Rint P
RP
Hermkens
Pedro H H
PH
Rutjes
Floris P J T
FP