title: Recurrent hepatitis C virus disease after liver transplantation and concurrent biliary tract complications: poor outcome.
abstract: Recurrent hepatitis C virus (HCV) infection is particularly aggressive in the post-liver transplantation setting, with rapid progression of liver fibrosis. Biliary complications remain a significant cause of morbidity following liver transplantation. Post-cholecystectomy biliary strictures are associated with advanced hepatic fibrosis. The aim of this retrospective study was to determine whether the presence of biliary complications affects survival in liver transplant recipients with recurrent HCV disease. The files of liver transplant recipients (53.7% male; mean age 52.7+/-10.3 yr) were reviewed for incidence, type and treatment of biliary complications, and findings were compared between those who developed recurrent HCV disease (n=47, 83.9%) and those who did not (n=9). Twenty-one biliary complications developed in 12 patients with recurrent HCV (25.5%). Treatment with endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography with balloon dilatation and stent placement or surgical revision was successful in nine (75%). Three biliary complications developed in three patients with no recurrence (p=NS). There was no statistically significant association between recurrent HCV disease and biliary complications. However, among those with recurrent disease, the recurrence was severe in nine of 12 recipients with biliary complications (75%) but in only nine of 35 without biliary complications (26%) (p=0.001). Death was documented in eight patients with severe recurrence (44.4%), including three (37.5%) with biliary complications and two (7%) with non-severe recurrence, neither of whom had biliary complications (p=0.003). Antiviral treatment was successful in nine of 25 patients (36%) who received it. On multivariate analysis, biliary complications were a significant predictor of severe recurrence (OR 27.0, 95% confidence interval 2.07-351.4) (p=0.012). Fibrosis stage in the second biopsy was significantly correlated with serum alanine aminotransferase (p=0.01) and with duration of biliary obstruction (p=0.07). In conclusion, biliary complications of liver transplantation strongly affect outcome in patients with recurrent HCV disease despite attempts to relieve the biliary obstruction and to treat the recurrent HCV disease.
authors.affiliation: Liver Institute and Department of Medicine D, Rabin Medical Center, Petah Tiqwa and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Lior H
authors.initials: LH
authors.lastname: Katz
authors.forename: Eitan
authors.initials: E
authors.lastname: Mor
authors.forename: Marius
authors.initials: M
authors.lastname: Brown
authors.forename: Nathan
authors.initials: N
authors.lastname: Bar-Nathan
authors.forename: Ezra
authors.initials: E
authors.lastname: Shaharabani
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Sulkes
authors.forename: Orit
authors.initials: O
authors.lastname: Pappo
authors.forename: Ran
authors.initials: R
authors.lastname: Tur-Kaspa
authors.forename: Ziv
authors.initials: Z
authors.lastname: Ben-Ari
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001660:Biliary Tract Diseases / Q000453:epidemiology*; D005260:Female; D005705:Gallbladder Diseases / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D012367:RNA, Viral / Q000097:blood; D012008:Recurrence; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D012367:RNA, Viral