title: [Lymphomatoid granulomatosis after treatment of an acute myeloid leukemia].
abstract: We report a case of lymphomatoid granulomatosis (LG), arising in a 60-year-old man in the setting of an acute myeloid leukemia. LG is a rare Epstein Barr virus (EBV) lymphoproliferative disorder, generally occurring in a context of immunodeficiency. Patients usually present with respiratory symptoms and bilateral pulmonary nodules. Histologically LG is characterized by an angiocientric and angiodestructive lymphoproliferation of B/EBV+ cells admixed with numerous reactive T cells. The differential diagnosis mainly includes pulmonary vasculitis and Hodgkin's lymphoma. The outcome of this lymphoproliferation is highly variable, ranging from an indolent process to an aggressive large cell lymphoma.
authors.affiliation: Département de Pathologie, Hôpital du Haut-lévêque, CHU Bordeaux, Avenue de Magellan, 33604 Pessac, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Ragage
authors.forename: Marie
authors.initials: M
authors.lastname: Parrens
authors.forename: Anne
authors.initials: A
authors.lastname: Banos
authors.forename: Michel
authors.initials: M
authors.lastname: Renoux
authors.forename: Hugues
authors.initials: H
authors.lastname: Bégueret
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Merlio
authors.forename: Antoine
authors.initials: A
authors.lastname: de Mascarel
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000473:pathology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D015703:Antigens, CD; D019309:Epstein-Barr Virus Nuclear Antigens