title: HLA alleles and haplotypes in French North African immigrants.
abstract: Human leukocyte antigen (HLA) haplotypes (n = 187) were genotyped and assigned by the mode of inheritance in migrant families from North Africa who reside in the Paris, France, area. The distribution of alleles and haplotypes in that population was compared with the one obtained in a control population of ancient French natives residing in the same area (248 independent haplotypes also assigned by the mode of inheritance were studied). The results in migrants reveal the following: (1) a higher diversity in the distribution of HLA-A and -DRB1 alleles; (2) lower frequencies of alleles common in our region, such as A*0201 B*1501, B*4001, and DRB1*0401 and increased frequencies of minor subtypes, such as A*3002 and DRB1*0402; and (3) distinct distributions of B/Cw, DRB1/DQB1 or B/Cw/DRB1/DQB1 haplotypes. The results also revealed that the four most frequent five-allele haplotypes in controls i.e., HLA-A*0101/B*0801/Cw*0701/DRB1*0301/DQB1*0201; A*0301/B*0702/Cw*0702/DRB1*1501/DQB1*0602 (both of Indo-Celtic origin); A*2902/B*4403/Cw*1601/DRB1*0701/DQB1*0202 (frequent in Western-Europeans); and A*0201/B*1501/Cw*0304/DRB1*0401/DQB1*0302, represent 10.5% of the total haplotypes in controls but 1.6% in North Africans. Conversely, 9 five-allele haplotypes in multiple copy in North Africans (among which A*3002/B*1801/Cw*0501/DRB1*0301/DQB1*0201 of Paleo-North African origin and A*0201/B*0702/Cw*0702/DRB1*1501/DQB1*0602 of ancient European and Paleo-North African origin) represent 9.6% of the total haplotypes in North Africans but 2.4% in controls. These results thus suggest a low degree of admixture between the two populations.
authors.affiliation: Laboratory of Immunology, Hôpital Robert Debré, Paris, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pédron
authors.forename: Karima
authors.initials: K
authors.lastname: Yakouben
authors.forename: Valérie
authors.initials: V
authors.lastname: Guérin
authors.forename: Enwar
authors.initials: E
authors.lastname: Borsali
authors.forename: Anne
authors.initials: A
authors.lastname: Auvrignon
authors.forename: Judith
authors.initials: J
authors.lastname: Landman
authors.forename: Corinne
authors.initials: C
authors.lastname: Alberti
authors.forename: Guy
authors.initials: G
authors.lastname: Leverger
authors.forename: André
authors.initials: A
authors.lastname: Baruchel
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Sterkers
mesh_terms: D000352:Africa, Northern / Q000208:ethnology; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D010297:Paris / Q000453:epidemiology; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens