title: A study on the antioxidant activities of some new benzazole derivatives.
abstract: The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10(-3) M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10(-3) M concentration.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, TR-06100 Tandogan, Ankara, Turkey. oren@pharmacy.ankara.edu.tr
authors.forename: O
authors.initials: O
authors.lastname: Temiz-Arpaci
authors.forename: T
authors.initials: T
authors.lastname: Coban
authors.forename: B
authors.initials: B
authors.lastname: Tekiner-Gulbas
authors.forename: B
authors.initials: B
authors.lastname: Can-Eke
authors.forename: I
authors.initials: I
authors.lastname: Yildiz
authors.forename: E
authors.initials: E
authors.lastname: Aki-Sener
authors.forename: I
authors.initials: I
authors.lastname: Yalcin
authors.forename: M
authors.initials: M
authors.lastname: Iscan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism; D001562:Benzimidazoles / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D051381:Rats; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D052160:Benzothiazoles; D001583:Benzoxazoles; D016166:Free Radical Scavengers; D013481:Superoxides; D009249:NADP