MTHFR 677TT genotype increases the risk for cervical artery dissections.
The methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism was studied in 174 German patients with cervical artery dissection (CAD). The results were compared with published data on 927 healthy German controls. In the series of patients, the frequency of T alleles and of TT carriers was slightly higher (13.8%) than among the healthy controls (10.6%). In patients with multiple dissections (n = 50), the proportion of TT carriers (18%) was found to be even higher and correlated with the number of events. The MTHFR C677T polymorphism was suggested to modify the risk for CAD.
Kloss
M
M
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D69120 Heidelberg, Germany.
Wiest
T
T
Hyrenbach
S
S
Werner
I
I
Arnold
M-L
ML
Lichy
C
C
Grond-Ginsbach
C
C
D000784:Aortic Dissection / Q000235:genetics*; D001158:Arteries / Q000473:pathology; D016022:Case-Control Studies; D005838:Genotype; D005858:Germany; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009333:Neck / Q000098:blood supply; D011110:Polymorphism, Genetic; D012307:Risk Factors
D042965:Methylenetetrahydrofolate Reductase (NADPH2)