title: Piperidines: a new class of urease inhibitors.
abstract: A variety of piperidines (2-12, 14-26) with variable substituents at N-atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254 microM. The size and electron-donating or -withdrawing effects of substituents influence the activity, which lead to the formation of urease inhibitors.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Zafar S
authors.initials: ZS
authors.lastname: Saify
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif Lodhi
authors.forename: Naeem
authors.initials: N
authors.lastname: Butt
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Ghulam Murtaza
authors.initials: GM
authors.lastname: Maharvi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-Ur-Rahman
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D010880:Piperidines; D014510:Urease