title: Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
abstract: Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
authors.affiliation: Department of Medicine II, St. Josef-Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Spiecker
authors.forename: Jamesk
authors.initials: J
authors.lastname: Liao
mesh_terms: D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000235:genetics; D015777:Eicosanoids / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010105:Oxygenases / Q000096:biosynthesis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
chemical_list: C000717350:CYP2J2 protein, human; D015777:Eicosanoids; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D000090762:Cytochrome P-450 CYP2J2