title: Parenteral nutrition in bone marrow transplantation.
abstract: Twenty-nine patients undergoing bone marrow transplantation (BMT) were randomised prospectively to evaluate the effect of parenteral nutrition (TPN) on morbidity and mortality. Fourteen patients received a standard regimen of TPN for 10 +/- 4 days (mean +/- SD). All patients had free access to oral diet, which was significantly reduced compared to pre-transplant intake. In the TPN group, serum bilirubin by day 14 and serum bilirubin and gamma glutamyl transferase by day 21 were significantly higher than in the controls (p < 0.05). These differences probably reflect the higher incidence of serious pyrexia (T > 38.5' C) and blood culture positive rates in the TPN group. Weight loss in the control group was significantly greater than that of the TPN group (p < 0.05). TPN did not affect time to grafting or incidence of graft-versus-host disease. The use of TPN in the nutritional support of patients in small BMT units requires careful consideration.
authors.affiliation: Department of Pathological Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK.
authors.forename: M
authors.initials: M
authors.lastname: Lough
authors.forename: R
authors.initials: R
authors.lastname: Watkins
authors.forename: M
authors.initials: M
authors.lastname: Campbell
authors.forename: K
authors.initials: K
authors.lastname: Carr
authors.forename: A
authors.initials: A
authors.lastname: Burnett
authors.forename: A
authors.initials: A
authors.lastname: Shenkin