title: A retrospective study on the use of acepromazine maleate in dogs with seizures.
abstract: Use of acepromazine (i.e., acetylpromazine) maleate in dogs with a history of seizures is reportedly contraindicated because of the risk of decreasing the seizure threshold in these animals. In this retrospective study, acepromazine was administered for tranquilization to 36 dogs with a prior history of seizures and to decrease seizure activity in 11 dogs. No seizures were seen within 16 hours of acepromazine administration in the 36 dogs that received the drug for tranquilization during hospitalization. After acepromazine administration, seizures abated for 1.5 to 8 hours (n=6) or did not recur (n=2) in eight of 10 dogs that were actively seizing. Excitement-induced seizure frequency was reduced for 2 months in one dog.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-4544, USA.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Tobias
authors.forename: Katia
authors.initials: K
authors.lastname: Marioni-Henry
authors.forename: Rebecca
authors.initials: R
authors.lastname: Wagner
mesh_terms: D000075:Acepromazine / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000075:Acepromazine