title: Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization.
abstract: A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and thermoresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.
authors.affiliation: Department of Chemistry, University of Rome La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Bontempo
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Masci
authors.forename: Piero
authors.initials: P
authors.lastname: De Leonardis
authors.forename: Luisa
authors.initials: L
authors.lastname: Mannina
authors.forename: Donatella
authors.initials: D
authors.lastname: Capitani
authors.forename: Vittorio
authors.initials: V
authors.lastname: Crescenzi
mesh_terms: D002236:Carbohydrate Conformation; D005609:Free Radicals / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D005609:Free Radicals; D011134:Polysaccharides