title: A head-to-head comparison of infusion and bolus doses of adenosine for stress myocardial contrast echocardiography.
abstract: BACKGROUND
  This study was a head-to-head, intraindividual comparison of the diagnostic accuracy and side effect profile of bolus and infusion administration of adenosine for stress myocardial contrast echocardiography (MCE).
  
  
  METHODS
  Adenosine MCE was performed in 64 subjects, referred for stress thallium-201 single-photon emission computed tomography (SPECT) for known or suspected CAD. Each patient received adenosine by multiple boluses (6-12 mg/bolus) and infusion (140 mug/kg per min for 6 min) forms in random order, given at least 20 minutes apart.
  
  
  RESULTS
  No prolonged or serious adverse events occurred during either adenosine bolus or infusion. Compared to SPECT imaging, the sensitivity, specificity, and concordance for the diagnosis of CAD were 77%, 87%, and 82% for adenosine infusion MCE and 81%, 90%, and 86% for adenosine bolus MCE, respectively.
  
  
  CONCLUSIONS
  Both adenosine infusion and adenosine bolus protocols are safe for MCE in humans and can be used for the diagnosis of CAD.
authors.affiliation: IInd Department of Medicine, Cardiology, KH der Elisabethinen Hospital, Linz, Austria. hans-joachim.nesser@elisabethinen.or.at
authors.forename: Hans Joachim
authors.initials: HJ
authors.lastname: Nesser
authors.forename: Jiefen
authors.initials: J
authors.lastname: Yao
authors.forename: Prem
authors.initials: P
authors.lastname: Soman
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Tkalec
authors.forename: Christian
authors.initials: C
authors.lastname: Ebner
authors.forename: Regina
authors.initials: R
authors.lastname: Steringer-Mascherbauer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Markt
authors.forename: David
authors.initials: D
authors.lastname: Samenuk
authors.forename: Choi-Keung
authors.initials: CK
authors.lastname: Ng
authors.forename: Fernando
authors.initials: F
authors.lastname: Morcerf
authors.forename: James E
authors.initials: JE
authors.lastname: Udelson
authors.forename: Natesa G
authors.initials: NG
authors.lastname: Pandian
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins; D016009:Chi-Square Distribution; D003287:Contrast Media; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D025401:Echocardiography, Stress; D004562:Electrocardiography; D005260:Female; D005466:Fluorocarbons; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
chemical_list: D000418:Albumins; D003287:Contrast Media; C099458:FS 069; D005466:Fluorocarbons; D014665:Vasodilator Agents; D000241:Adenosine