title: A feasibility study: evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT.
abstract: OBJECTIVE
  The therapeutic response to radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) often is evaluated by comparing pre- and post-RFA computed tomography (CT). However, judgment about whether an ablative margin, ie, 5-10 mm of normal hepatic tissue, is ensured sometimes is difficult. The aim of this study is to assess the feasibility of fusion images of pre- and post-RFA CT.
  
  
  METHODS
  HCCs (n = 20) sized 13 +/- 5 mm (range, 4-23 mm) were included. For pre-RFA CT, the arterial phase of intravenous dynamic CT (n = 17), CT arterioportography (n = 2), and CT hepatic arteriography (n = 1) was used. Using automatic image registration software (n = 20) and a manual segmentation technique (n = 4), fusion images were created in combination with post-RFA CT (equilibrium phase of intravenous CT).
  
  
  RESULTS
  Automatic image registration and manual segmentation technique took approximately 2-3 and 5 minutes, respectively. Total time required for the creation of fusion images was less than 10 minutes in all cases. Fusion images enabled easier understanding of the relationship between the tumor and ablation zone, helping judge whether an ablative margin was ensured.
  
  
  CONCLUSIONS
  Fusion of pre- and post-RFA CT images is considered a feasible tool in the evaluation of RFA therapy for HCC.
authors.affiliation: Department of Clinical Radiology, Hiroshima University Hospital, Hiroshima, 734-8551 Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Fujioka
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Minoru
authors.initials: M
authors.lastname: Ishifuro
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakizawa
authors.forename: Masao
authors.initials: M
authors.lastname: Kiguchi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Matsuura
authors.forename: Masashi
authors.initials: M
authors.lastname: Hieda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tachikake
authors.forename: Farzana
authors.initials: F
authors.lastname: Alam
authors.forename: Takashi
authors.initials: T
authors.lastname: Furukawa
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Ito
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000601:surgery*; D017115:Catheter Ablation; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media