Mice with experimental colitis show an altered metabolism with decreased metabolic rate.
Patients with inflammatory bowel disease (IBD) suffer from body weight loss, malnutrition, and several other metabolic alterations affecting their quality of life. The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. Clinical symptoms and inflammatory markers revealed the presence of an ongoing inflammatory response in the DSS-treated mice. Mice with acute inflammation had decreased body weight, respiratory exchange ratios (RER), food intake, and body fat content. Mice with chronic inflammation had decreased nutrient uptake, body fat content, locomotor activity, metabolic rates, and bone mineral density. Despite this, the body weight, food and water intake, lean mass, and RER of these mice returned to values similar to those in healthy controls. Thus, murine experimental colitis is associated with significant metabolic alterations similar to IBD patients. Our data show that the metabolic responses during acute and chronic inflammation are different, although the metabolic rate is reduced in both phases. These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology.
Melgar
Silvia
S
Department of Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca Research and Development, Mölndal, Sweden. silvia.melgar@astrazeneca.com
Bjursell
Mikael
M
Gerdin
Anna-Karin
AK
Svensson
Lennart
L
Michaëlsson
Erik
E
Bohlooly-Y
Mohammad
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001823:Body Composition; D002784:Cholesterol / Q000097:blood; D003092:Colitis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D003106:Colon / Q000378:metabolism / Q000503:physiopathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D015212:Inflammatory Bowel Diseases; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D016264:Dextran Sulfate; D002784:Cholesterol; D000410:Alanine Transaminase; D008775:Methylprednisolone