Effects of soybean food pellets on m-CPP-induced anxiety model of mice.
In this study, we gave the soybean powder-added food pellets (soybean pellets) to investigate anti-anxious effects of soybean in male mice. Twenty eight days after feeding control pellets or soybean pellets, we observed the behavioral changes in the elevated plus maze. There was no significant difference on the time spent in the open arms (%) between mice fed the control and soybean pellets. When we administered m-chlorophenylpiperazine (m-CPP, 2.5 mg/kg, i.p.) to mice, the mice fed control pellets showed the decrease in the time spent in the open arms, suggesting that anxiety-like behavior was induced by m-CPP. On the other hand, we could not observe the m-CPP-induced anxiety-like behavior in mice fed soybean pellets in this test. These results suggest that soybean pellets may attenuate anxiety-like behavior in mice.
Mamiya
Takayoshi
T
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan. mamiya@ccmfs.meijo-u.ac.jp
Asanuma
Takamasa
T
Kawai
Yoshiaki
Y
Hasegawa
Yuya
Y
Nishimura
Atsuhisa
A
Kumazawa
Toshihiko
T
Ukai
Makoto
M
D000821:Animal Feed; D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000517:prevention & control*; D004195:Disease Models, Animal; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D010879:Piperazines / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013025:Glycine max
D010879:Piperazines; D017366:Serotonin Receptor Agonists; C015068:1-(3-chlorophenyl)piperazine