title: An in situ approach for nickel-catalyzed cycloaddition.
abstract: A convenient method for preparing pyridines from air-stable, commercially available catalyst precursors is described. The addition of n-BuLi to Ni(acac)2 and an NHC salt (such as IPr.HCl or SIPr.HCl) rapidly generates an active Ni0/NHC catalyst for the cycloaddition of diynes and nitriles that affords pyridines without a decrease in observed yields. The in situ method also converts diynes and carbon dioxide to the corresponding pyrones.
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Tekavec
authors.forename: Gang
authors.initials: G
authors.lastname: Zuo
authors.forename: Kristina
authors.initials: K
authors.lastname: Simon
authors.forename: Janis
authors.initials: J
authors.lastname: Louie
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D053280:Diynes / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*
chemical_list: D053280:Diynes; D011725:Pyridines; D011753:Pyrones; D002245:Carbon Dioxide; D009532:Nickel