title: Snail in the frame of malignant tumor recurrence.
abstract: Snail plays an important role in the epithelial-to-mesenchymal transition during development and in tumor progression. Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells. Recently, a new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model. Comparative transcriptome analysis of human primary breast cancers suggests that elevated Snail expression is correlated with decreased relapse-free survival. Further characterization of Snail as master regulator in this process might enhance our understanding of the molecular and cellular changes during and after breast tumor recurrence.
authors.affiliation: Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, VIB-Ghent University, Belgium.
authors.forename: Bram
authors.initials: B
authors.lastname: De Craene
authors.forename: Geert
authors.initials: G
authors.lastname: Berx
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D018450:Disease Progression; D004847:Epithelial Cells; D005260:Female; D015870:Gene Expression; D006801:Humans; D059630:Mesenchymal Stem Cells; D051379:Mice; D008822:Mice, Transgenic; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011237:Predictive Value of Tests; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D000071250:Snail Family Transcription Factors; D014157:Transcription Factors