title: Base-base interactions in the minor groove of double-stranded DNA.
abstract: A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
authors.forename: Tongfei
authors.initials: T
authors.lastname: Wu
authors.forename: Koen
authors.initials: K
authors.lastname: Nauwelaerts
authors.forename: Arthur
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: Matheus
authors.initials: M
authors.lastname: Froeyen
authors.forename: Eveline
authors.initials: E
authors.lastname: Lescrinier
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000225:Adenine / Q000737:chemistry*; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000737:chemistry*
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009705:Nucleosides; D004247:DNA; D000225:Adenine; D013941:Thymine