Prediction of target range of intact parathyroid hormone in hemodialysis patients with artificial neural network.
The application of artificial neural network (ANN) to predict outcome and explore potential relationships among clinical data is increasing being used in many clinical scenarios. The aim of this study was to validate whether an ANN is a useful tool for predicting the target range of plasma intact parathyroid hormone (iPTH) concentration in hemodialysis patients. An ANN was constructed with input variables collected retrospectively from an internal validation group (n = 129) of hemodialysis patients. Plasma iPTH was the dichotomous outcome variable, either target group (150 ng/L<or= iPTH <or=300 ng/L) or non-target group (iPTH< 150 ng/L or iPTH hormone >300 ng/L). After internal validation, the ANN was prospectively tested in an external validation group (n = 32) of hemodialysis patients. The final ANN was a multilayer perceptron network with six predictors including age, diabetes, hypertension, and blood biochemistries (hemoglobin, albumin, calcium). The externally validated ANN provided excellent discrimination as appraised by area under the receiver operating characteristic curve (0.83 +/- 0.11, p = 0.003). The Hosmer-Lemeshow statistic was 5.02 (p= 0.08 > 0.05) which represented a good-fit calibration. These results suggest that an ANN, which is based on limited clinical data, is able to accurately forecast the target range of plasma iPTH concentration in hemodialysis patients.
Wang
Yuh-Feng
YF
Department of Nuclear Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Buddhist Tzu Chi University, Hualien, Taiwan.
Hu
Tsung-Ming
TM
Wu
Chia-Chao
CC
Yu
Fu-Chiu
FC
Fu
Chao-Ming
CM
Lin
Shih-Hua
SH
Huang
Wei-Hsin
WH
Chiu
Jainn-Shiun
JS
D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D010281:Parathyroid Hormone / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D006435:Renal Dialysis; D012189:Retrospective Studies
C470125:PTH protein, human; D010281:Parathyroid Hormone