title: [Structural-functional organization of Golgi apparatus].
abstract: This review is dedicated to the structure and function of Golgi apparatus (GA). It summarizes contemporary data published in numerous experimental papers and in several reviews. Possible ways of intra-Golgi transport of proteins, existent models of structural and functional organization of Golgi organelle, as well as the issues of its biogenesis, posttranslational modification and sorting of proteins and lipids, and mechanisms of their traffic-king are discussed. Special attention is paid to the role of coatomer proteins (COPI, COPII and clathrin), fusion proteins (SNAREs), and small GTPases (ARF, SARI) in the secretory pathway. In addition, the phenomena of ultrastructural alterations of GA due to various functional conditions and physiological stimuli are specifically accented. We included in this review our original data on a probable involvement of GA in water transport, and on the organization of atypical GA in microsporidia--intracellular parasitic protists.
authors.forename: E S
authors.initials: ES
authors.lastname: Snigirevskaia
authors.forename: Iu Ia
authors.initials: IuIa
authors.lastname: Sokolova
authors.forename: Ia Iu
authors.initials: IaIu
authors.lastname: Komissarchik
mesh_terms: D000818:Animals; D020756:Coatomer Protein / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D006056:Golgi Apparatus / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D050356:Lipid Metabolism; D008854:Microscopy, Electron; D016814:Microsporidia / Q000648:ultrastructure; D059828:Plant Cells; D021381:Protein Transport; D050600:SNARE Proteins / Q000502:physiology; D014867:Water / Q000378:metabolism
chemical_list: D020756:Coatomer Protein; D050600:SNARE Proteins; D014867:Water; D020558:GTP Phosphohydrolases