Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No.
Iorio
A
A
Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Italy. iorioa@unipg.it
Agnelli
G
G
D000925:Anticoagulants / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D032984:Ethics, Research; D000077425:Fondaparinux; D017408:Guidelines as Topic; D006801:Humans; D010919:Placebos; D011134:Polysaccharides / Q000627:therapeutic use*; D012107:Research Design; D013923:Thromboembolism / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000188:drug therapy*
D000925:Anticoagulants; D010919:Placebos; D011134:Polysaccharides; D000077425:Fondaparinux