Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma.
OBJECTIVE
To investigate the association between the occurrence of uterine leiomyoma and two SNPs of the CYP 2A13 and CYP 1A1 genes.


METHODS
Prospective case control study with 132 women with clinically and surgically diagnosed uterine leiomyoma and 260 controls. Genotyping was performed by polymerase chain reaction (PCR) based amplification of CYP 2A13 and CYP 1A1 genes, and restriction fragment length polymorphism (RFLP) analysis.


RESULTS
Comparing women with uterine leiomyoma and controls, we demonstrate statistical significant differences of allele frequency and genotype distribution for the CYP 1A1 polymorphism (P = 0.025 and P = 0.046, respectively). Furthermore, for the CYP 2A13 polymorphism we found a significant difference concerning allele frequency (P = 0.033). However, for the genotype distribution, only borderline significance was observed (P = 0.064).


CONCLUSIONS
The CYP 2A13 and CYP 1A1 SNPs are associated with uterine leiomyoma in a Caucasian population and may contribute to the understanding of the pathogenic mechanisms of uterine leiomyoma.
Herr
D
D
Department of Obstetrics and Gynecology, Ulm University Medical Center, Ulm, Germany. daherr@gmx.de
Bettendorf
H
H
Denschlag
D
D
Keck
C
C
Pietrowski
D
D
D000328:Adult; D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D018231:Leiomyomatosis / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014594:Uterine Neoplasms / Q000235:genetics*; D044465:White People
D001189:Aryl Hydrocarbon Hydroxylases; C414206:CYP2A13 protein, human; D019363:Cytochrome P-450 CYP1A1