Diffuse cerebral vasoconstriction (Call-Fleming syndrome) and stroke associated with antidepressants.
Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.
Noskin
Olga
O
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Jafarimojarrad
Elham
E
Libman
Richard B
RB
Nelson
Jeffrey L
JL
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008875:Middle Aged; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D014661:Vasoconstriction / Q000187:drug effects*
D000928:Antidepressive Agents