title: Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1.
abstract: Functional activity of macrophages and intensity of T cell immune response in mice were studied after intravaginal and intraperitoneal infection with herpes simplex virus type 1 and DNA vaccination in combination with adjuvant treatment (recombinant granulocyte-macrophage colony-stimulating factor and glucosaminylmuramyl dipeptide). DNA vaccination induced a virus-specific T cell immune response with no macrophagic inflammatory reaction. Infection with herpes simplex virus type 1 was accompanied by sustained inflammation, but not by the T cell immune response.
authors.affiliation: N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Nagurskaya
authors.forename: L G
authors.initials: LG
authors.lastname: Zaitseva
authors.forename: N V
authors.initials: NV
authors.lastname: Kobets
authors.forename: I V
authors.initials: IV
authors.lastname: Kireeva
authors.forename: V A
authors.initials: VA
authors.lastname: Bekhalo
authors.forename: A Yu
authors.initials: AY
authors.lastname: Kozlov
authors.forename: R R
authors.initials: RR
authors.lastname: Klimova
authors.forename: S V
authors.initials: SV
authors.lastname: Gur'yanova
authors.forename: T M
authors.initials: TM
authors.lastname: Andronova
authors.forename: L N
authors.initials: LN
authors.lastname: Shingarova
authors.forename: E F
authors.initials: EF
authors.lastname: Boldyreva
authors.forename: O V
authors.initials: OV
authors.lastname: Nekrasova
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D002465:Cell Movement; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006561:Herpes Simplex / Q000097:blood*; D018259:Herpesvirus 1, Human / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019444:Vaccines, DNA / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D019444:Vaccines, DNA; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor