Adrenal insufficiency in T-cell lymphoma.
Primary adrenal lymphoma (PAL) is an extremely rare neoplasm of T-cell origin. Here we describe a 42-year-old woman who suffered from intermittent fevers and night sweats of 3 months duration. Laboratory results, imaging, pathology, and immunohistological examination led to a final diagnosis of primary adrenal T-cell lymphoma (PATL) with adrenal insufficiency. The patient received combination chemotherapy and prednisolone but expired 2 months after the treatment. Most reported PAL patients who have received only one therapeutic modality have unsatisfactory survival rates resulting from tumor recurrence and/or postchemotherapy infections. In contrast, one patient who received an adrenectomy followed by low-dose radiotherapy experienced long-term survival. A combination of therapeutic modalities may improve prognosis for patients with PATL, although the case numbers are too small to draw any conclusions.
Tsai
Wen-Chiuan
WC
Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan.
Hsieh
Cheng-Da
CD
Cheng
Ming-Fang
MF
Lin
Chih-Kung
CK
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D000309:Adrenal Insufficiency / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy*