Replicon typing of plasmids encoding resistance to newer beta-lactams.
Polymerase chain reaction-based replicon typing represents a novel method to describe the dissemination and follow the evolution of resistance plasmids. We used this approach to study 26 epidemiologically unrelated Enterobacteriaceae and demonstrate the dominance of incompatibility (Inc) A/C or Inc N-related plasmids carrying some emerging resistance determinants to extended-spectrum cephalosporins and carbapenems.
Carattoli
Alessandra
A
Department of Infectious, Parasituc, Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy. alecara@iss.it
Miriagou
Vivi
V
Bertini
Alessia
A
Loli
Alexandra
A
Colinon
Celine
C
Villa
Laura
L
Whichard
Jean M
JM
Rossolini
Gian Maria
GM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012093:Replicon / Q000235:genetics*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012680:Sensitivity and Specificity; D018440:beta-Lactam Resistance / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams