title: Splanchnic acid-base status and urea metabolism in uremic rats.
abstract: Acidosis may alter hepato-splanchnic amino acid metabolism during uremia.26 uremic rats and 30 controls were studied for portal and arterial acid-base balance and urea synthesis during enteral nutrition. Uremic rats exhibited increased (p < 0.05) portal H(+) (47.20 +/- 0.018 vs 43.05 +/- 0.49 nmol/I) and decreased HCO(3)(-) (19.45 +/- 0.69 vs 23.01 +/- 0.57 mmol/l) without significant change in arterial H(+) (45.29 +/- 1.13 vs 43.15 +/- 0.49) and HCO(3)(-) (18.41 +/- 0.64 vs 19.59 +/- 0.49). Porto-arterial difference showed an intestinal HCO(3)(-) release in controls only (3.53 +/- 0.64 mmol/l). Urea synthesis rate was significantly enhanced by enteral nutrition in controls only: 54.33 +/- 17.3 vs -11.8 +/- 20 micromol/min 100g body mass. Thus, during uremia, portal acidosis was associated with a decrease in enteral nutrition-induced urea synthesis.
authors.affiliation: Laboratoire de Thérapeutique, Biologie, Université Joseph Fourier, 38041 Grenoble Cédex, France.
authors.forename: N
authors.initials: N
authors.lastname: Cano
authors.forename: X
authors.initials: X
authors.lastname: Leverve
authors.forename: J
authors.initials: J
authors.lastname: Di Costanzo-Dufetel
authors.forename: R
authors.initials: R
authors.lastname: Novaretti
authors.forename: J P
authors.initials: JP
authors.lastname: Reynier