title: [Near infrared spectrometry (NIRS) method for the determination of borneol in sustained-release drugs].
abstract: In order to detect the release profile of borneol in sustained-release preparations, a series of NIRS calibration models were established on the basis of chemometrics and internal relationships between NIRS and analytical concentrations of samples, which contained the same substances as the preparations. Partial least square (PLS) algorithm was used to establish the model for predicting the content of borneol. The effect of spectra types, concentration range of samples, and calibration range on the models and predicting results were investigated. It was found that the best calibration models and prediction results can be obtained by using original spectra in the 5,314-7,032 cm(-1) region. The models established according to standards' concentration levels are better than those established without considering concentration levels. Using the model 2 in which calibration standards had medium or high concentration levels, rapid and accurate measurement of borneol released from sustained-release preparation was realized. The results indicated that the method and models provide valuable criteria for developing sustained-release borneol preparations.
authors.affiliation: East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Ni
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Li-guo
authors.initials: LG
authors.lastname: Zhang
mesh_terms: D001892:Camphanes / Q000032:analysis*; D003692:Delayed-Action Preparations / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D001892:Camphanes; D003692:Delayed-Action Preparations; C022871:isoborneol