title: Transbronchoscopic pulmonary emphysema treatment: 1-month to 24-month endoscopic follow-up.
abstract: OBJECTIVE
  Describe the results of a 1- to 24-month follow-up of individuals undergoing transbronchoscopic placement of one-way valves.
  
  
  METHODS
  Longitudinal, noncomparative study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Nineteen heterogeneous emphysema patients.
  
  
  RESULTS
  Pulmonary function testing, imaging examination, and videobronchoscopy were performed at 1, 3, 6, 12, and 24 months after the insertion of one-way valves. Mean age was 67.63 +/- 8.71 years, mean body mass index (BMI) was 24.02 +/- 2.65, and mean exposure to smoking was 65.32 +/- 27.46 pack-years (+/- SD). Baseline BODE index (BMI, degree of airflow obstruction and dyspnea, exercise capacity as measured by the 6-min walk test [6MWT]) was 7 to 10 in 10 patients (estimated 4-year mortality, 80%) and 5 to 6 in 9 patients (estimated 4-year mortality, 40%). Sixty-four valves were inserted. There was no procedure-related mortality. Nonsustained atelectasis was observed within 48 h in 2 of 12 patients with right upper lobe occlusion. Fifty-six bronchoscopic examinations were performed in 24 months. Granulomas not requiring treatment were the main complication. Mucus clogging the valve, mainly at 1 month, was easily cleaned. Eighteen patients completed the 1- and 3-month follow-ups, 14 patients completed the 6-month follow-up, 11 patients completed the 12-month follow-up, and 5 patients completed the 24-month follow-up. Improvement was observed in the 6MWT after 1 month (p = 0.028) and in the BODE index at 3 months (p = 0.002). FEV1 or FVC improvement > or = 12% or > or = 150 mL was observed, respectively, in 4 of 18 patients and 8 of 18 patients at 1 month, 4 of 18 patients and 7 of 18 patients at 3 months, and in 3 of 14 patients and 5 of 14 patients at 6 months. After 24 months, one of five patients and three of five patients, respectively, retained an FEV1 and FVC change > or = 12% or > or = 150 mL. Significant improvement (decrease > or = 4%) in the St. George Respiratory Questionnaire was observed at 3 months and 6 months in three of four domains.
  
  
  CONCLUSIONS
  Endobronchial valves are safe, but the criteria to measure improvement and to select patients should be refined. Atelectasis should be reconsidered as primary treatment goal.
authors.affiliation: Department of Thoracic Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, Sala 2050 MI CEP, 90035-004 Porto Alegre, RS, Brazil. hugo@oliveira.com
authors.forename: Hugo G
authors.initials: HG
authors.lastname: de Oliveira
authors.forename: Amarilio V
authors.initials: AV
authors.lastname: Macedo-Neto
authors.forename: Angela B
authors.initials: AB
authors.lastname: John
authors.forename: Sandra
authors.initials: S
authors.lastname: Jungblut
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Prolla
authors.forename: Sérgio S
authors.initials: SS
authors.lastname: Menna-Barreto
authors.forename: Elaine A F
authors.initials: EA
authors.lastname: Fortis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy / Q000379:methods*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011184:Postoperative Period; D011656:Pulmonary Emphysema / Q000601:surgery*; D012129:Respiratory Function Tests