title: Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.
abstract: A 79-year-old woman visiting our hospital with chief complaints of epigastric pain and jaundice was emergently admitted. Her alpha-fetoprotein (AFP) level was as high as 2265 ng/mL at admission. Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding into the cystic duct and gallbladder from the junction between the middle portion of the bile duct and the right and left hepatic ducts. Surgery revealed a tumor extending from the extrahepatic bile duct (EHBD) to the cystic duct, with no intrahepatic tumor components. The tumor was histologically diagnosed as an AFP-producing cholangiocarcinoma of the clear cell type, originating from the EHBD. None of the previously reported cholangiocarcinomas of the AFP-producing clear cell type have been confined to the EHBD or have been resectable in a curative manner without hepatectomy.
authors.affiliation: Department of Surgery, Saitama Medical School, Saitama, Japan. miyazawa@saitama-med.ac.jp
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Torii
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Toshimitsu
authors.forename: Nao
authors.initials: N
authors.lastname: Kamizasa
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Nozomi
authors.initials: N
authors.lastname: Shinozuka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishizawa
authors.forename: Isamu
authors.initials: I
authors.lastname: Koyama
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D018281:Cholangiocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins