title: Skin manifestations in acromegaly.
abstract: Cutaneous changes in acromegaly result from excess GH and IGF-1 action on skin cells and adnexae. Skin puffiness due to dermal glycosaminoglycan accumulation and edema are most prominent in the face, hands and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered. Alteration in skin capillaries produce increased vasoconstriction. Discerning these changes contributes to early diagnosis and treatment of this high-morbidity disorder. Controlling GH and IGF-1 over-secretion alleviates most cutaneous manifestations of acromegaly; however, regression may be incomplete.
authors.affiliation: Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA.
authors.forename: Anat
authors.initials: A
authors.lastname: Ben-Shlomo
authors.forename: Shlomo
authors.initials: S
authors.lastname: Melmed
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone