[Comparison of the diagnostic value of recombinant antigens and synthetic peptides that mimic the immunogenic epitopes of the envelop protein gp41 in the enzyme immunodetection of HIV-1 antibodies].
The study was undertaken to comparatively examine the efficiency of HIV antibody detection by enzyme immunoassay using recombinant antigens and synthetic peptides containing the most immunodominant region of the human immunodeficiency virus envelop protein gp41-cytotoxic T-lymphocytic (CTL) epitope. The application of the synthetic peptides that mimic this region has been to be inadequately effective. The recombinant proteins that contain the CTL epitope may be successfully used for the diagnosis of HIV-1, by using enzyme immunoassay as they show a higher sensitivity in detecting antibodies than do the synthetic peptises.
Baranova
E N
EN
Puzyrev
V F
VF
Van'kova
O E
OE
Pimenov
V K
VK
Burkov
A N
AN
Obriadina
A P
AP
Ulanova
T I
TI
D018984:Epitopes, T-Lymphocyte / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D007124:Immunoenzyme Techniques / Q000379:methods*; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D011237:Predictive Value of Tests; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41; D016056:Immunodominant Epitopes; D010455:Peptides; D011994:Recombinant Proteins