Experimental wound healing using microamperage electrical stimulation in rabbits.
We investigated the effects of microamperage electrical stimulation (MES) on the healing of skin incision in rabbits. Thirty male adult rabbits were randomly divided into sham-treated and experimental groups. Each group was divided into three subgroups, based on the duration of experiment (4, 7, and 15 days). A full-thickness incision was made on the skin of each rabbit. The experimental group received an MES of 200 microamperes current intensity for 2 h/day. Morphometrical and biomechanical evaluations were carried out. The mean number of fibroblasts at day 7 and the mean of tensile strength at day 15 were found to be significantly higher for the experimental group than for those in the sham-treated group (p < 0.01 and p < 0.05, respectively). Daily application of MES significantly accelerated the wound-healing process of full-thickness incision in the rabbits' skin.
Bayat
Mohammad
M
Cell and Molecular Biology Research Center and Department of Anatomy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. bayat_m@yahoo.com
Asgari-Moghadam
Zahra
Z
Maroufi
Mohammad
M
Rezaie
Fatemeh-Sadat
FS
Bayat
Maryam
M
Rakhshan
Mohammad
M
D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D007150:Immunohistochemistry; D008297:Male; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D013718:Tensile Strength; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*