title: Prognosis of ovarian cancer subsequent to venous thromboembolism: a nationwide Danish cohort study.
abstract: BACKGROUND
  Venous thromboembolism (VTE) is associated with ovarian cancer and may impact the prognosis of ovarian cancer. Our aims were to examine the extent of disease at the time of the diagnosis of ovarian cancer and to estimate the impact of VTE on survival of ovarian cancer.
  
  
  METHODS
  We identified 12,835 ovarian cancer patients diagnosed from 1980 to 2003 in the Danish Cancer Registry and obtained information on previous primary VTE diagnosis from the Danish National Hospital Discharge Registry. Ovarian cancer patients with previous VTE related to other cancers, surgery, or pregnancy were excluded. The vital status was determined by linking data to the Civil Registration System.
  
  
  RESULTS
  We identified 50 ovarian cancer patients diagnosed less than 4 months after the VTE and 78 ovarian cancer patients diagnosed more than 4 months after the VTE diagnosis. Advanced stages tended to be more common among patients with VTE. One-year survivals were 44% and 54% among the two VTE groups, compared with 63% among patients without VTE. Adjusted (for age, calendar time, comorbidity, and FIGO-stage) mortality ratios were 1.7 (95% CI = 1.2-2.5) and 1.2 (95% CI = 0.8-1.7), respectively.
  
  
  CONCLUSIONS
  Ovarian cancer diagnosed less than four months before VTE is associated with an advanced stage and a poorer prognosis.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus, Denmark. u30086@aas.nja.dk
authors.forename: Mette S
authors.initials: MS
authors.lastname: Tetsche
authors.forename: Mette
authors.initials: M
authors.lastname: Nørgaard
authors.forename: Lars
authors.initials: L
authors.lastname: Pedersen
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Lash
authors.forename: Henrik T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000401:mortality*; D011379:Prognosis; D016019:Survival Analysis; D013923:Thromboembolism / Q000209:etiology*; D013997:Time Factors