Juxtaposed half-cystines as disulphide bridged partners in protein tertiary structure.
Disulphide bridges involving juxtaposed half-cystines are observed in a number of protein three-dimensional structures analyzed from the Protein Data Bank. These disulphide bridges comprise a 'ring of 8-atoms' corresponding to Calpha1-C'-N-Calpha2-Cbeta2-Sgamma2-Sgamma1-Cbeta1-Calpha1 in the two half-cystines. The presence of such disulphide bridges introduces a 'bend' or 'kink' in the protein polypeptide chain.
Guruprasad
Kunchur
K
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India. guru@ccmb.res.in
Kartik
V Jai
VJ
Lavanya
T
T
Guruprasad
Lalitha
L
D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism*; D004220:Disulfides / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
D004220:Disulfides; D011506:Proteins; D003545:Cysteine