Mcm-2 protein expression predicts prognosis better than Ki-67 antigen in oral cavity squamocellular carcinoma.
BACKGROUND
The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value.


METHODS
Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed.


RESULTS
A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors. A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%).


CONCLUSIONS
The results suggested that the expression of Mcm-2 protein may be used as a prognostic factor in patients with squamocellular carcinoma of the oral cavity.
Szelachowska
Jolanta
J
Department of Oncology, Wroclaw Medical University, Plac Hirszfelda 12, 53-413 Wroclaw, Poland. rem@onet.pl
Dziegiel
Piotr
P
Jelen-Krzeszewska
Joanna
J
Jelen
Michal
M
Matkowski
Rafal
R
Pomiecko
Agnieszka
A
Spytkowska
Barbara
B
Jagas
Maria
M
Gisterek
Iwona
I
Kornafel
Jan
J
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018797:Cell Cycle Proteins / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D064111:Minichromosome Maintenance Complex Component 2; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009687:Nuclear Proteins / Q000096:biosynthesis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies
D018797:Cell Cycle Proteins; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; C084859:MCM2 protein, human; D064111:Minichromosome Maintenance Complex Component 2