Plasmodium vivax genetic diversity: microsatellite length matters.
The Plasmodium vivax genome is very diverse but has a relatively low abundance of microsatellites. Leclerc et al. had shown that these di-nucleotide repeats have a low level of polymorphism, suggesting a recent bottleneck event in the evolutionary history of P. vivax. By contrast, in a recent paper, Imwong et al. show that there is a very high level of microsatellite diversity. The difference in these results is probably due to the set array lengths chosen by each group. Longer arrays are more diverse than are shorter ones because slippage mutations become exponentially more common with an increase in array length. These studies highlight the need to consider carefully the application and design of studies involving microsatellites.
Russell
Bruce
B
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0811, Australia. bruce.russell@cdu.edu.au
Suwanarusk
Rossarin
R
Lek-Uthai
Usa
U
D000818:Animals; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D018895:Microsatellite Repeats; D010966:Plasmodium vivax / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D016054:DNA, Protozoan