The role of hypoxia inducible factor-1 in cell metabolism--a possible target in cancer therapy.
In many cancer types, intratumoural hypoxia is linked to increased expression and activity of the transcription factor hypoxia-inducible factor (HIF-1alpha), which is associated with poor patient prognosis. This increased the interest in HIF-1alpha as a cancer drug target. Further, HIF-1alpha has also a central role in the adaptive cellular programme responding to hypoxia in normal tissues. Many of the HIF-1alpha-regulated genes encode enzymes of metabolic pathways. Therefore, studying the link and the feedback mechanisms between metabolism and HIF-1alpha is of major importance to find new and specific therapeutic strategies.
Bel Aiba
Rachida S
RS
University of Kaiserslautern, Faculty of Chemistry, Department of Biochemistry, Erwin-Schrödinger Strasse 54, D-67663 Kaiserslautern, Germany.
Dimova
Elitsa Y
EY
Görlach
Agnes
A
Kietzmann
Thomas
T
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D014158:Transcription, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D051793:Hypoxia-Inducible Factor 1