Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4'',5'',6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I(2) in trigol is also reported.
Anuradha
V
V
Natural Products Laboratory, Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Srinivas
Pullela V
PV
Rao
R Ranga
RR
Manjulatha
K
K
Purohit
Muralidhar G
MG
Rao
J Madhusudana
JM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005419:Flavonoids / Q000138:chemical synthesis* / Q000302:isolation & purification* / Q000494:pharmacology; D006860:Hydrogen Bonding; D051379:Mice; D015394:Molecular Structure; D043842:Ochnaceae / Q000737:chemistry*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids