title: Reversal of idiopathic pulmonary arterial hypertension and allograft pneumonectomy after single lung transplantation.
abstract: Prior to the advent of effective medical therapies, the only treatment option for patients with idiopathic pulmonary arterial hypertension (IPAH) was lung transplantation. We present the case of a woman who underwent single-lung transplantation for the treatment of IPAH > 10 years ago in whom chronic rejection developed. Despite complete obliteration of the allograft, it was noted that her PA pressure levels had almost normalized. Therefore, an allograft pneumonectomy was performed. To our knowledge, this is the first reported case of the regression of pulmonary vascular disease following lung transplantation with subsequent successful removal of the allograft.
authors.affiliation: Department of Cardiothoracic Surgery, National Naval Medical Center, Bethesda, MD, USA.
authors.forename: Subrato
authors.initials: S
authors.lastname: Deb
authors.forename: Joon
authors.initials: J
authors.lastname: Yun
authors.forename: Nelson
authors.initials: N
authors.lastname: Burton
authors.forename: Edward
authors.initials: E
authors.lastname: Omron
authors.forename: John
authors.initials: J
authors.lastname: Thurber
authors.forename: Steven D
authors.initials: SD
authors.lastname: Nathan
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology / Q000601:surgery*; D016040:Lung Transplantation; D011013:Pneumonectomy; D014692:Ventilation-Perfusion Ratio