title: Stereotactic radiosurgery as a salvage treatment for recurrent epipharyngeal carcinoma.
abstract: Fourteen patients with recurrent epipharyngeal carcinoma (EPC) were treated by gamma knife stereotactic radiosurgery. The tumor volume ranged from 0.3 to 80 ml (median 18.9 ml). Treatment was done with a tumor margin dose of 10-27 Gy (median 15 Gy). The median follow-up period was 15 months (range 2-47 months). Ten patients were alive and 4 were dead at the end of the follow-up period. In 6 patients (43%), the tumor disappeared or decreased in size until the end of the follow-up period. In 2 (14%), the tumor remained unchanged in size. In 6 (43%), the tumor showed regression initially but was enlarged later. A second radiosurgery was performed in 4 of those 6 cases and the tumor decreased in size again in 3 of them. Thus, the overall control rate of local tumor was 79% (11/14). In selected patients with recurrent EPC, stereotactic radiosurgery can be considered as a salvage treatment producing local control.
authors.affiliation: Gamma Knife Center, Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.
authors.forename: Kyota
authors.initials: K
authors.lastname: Oda
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Mori
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kida
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yokoi
authors.forename: Yuta
authors.initials: Y
authors.lastname: Shibamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D012086:Reoperation; D013997:Time Factors