Successful anticoagulation with bivalirudin in antithrombin-deficient pediatric patient undergoing stent placement.
Many pediatric patients requiring anticoagulation during interventional heart catheterizations have antithrombin (AT) deficiency. AT is a necessary cofactor for heparin inhibition of thrombin. Without sufficient AT, these patients are at increased risk for thrombotic complications. This case describes the successful use of bivalirudin, a direct thrombin inhibitor, as an anticoagulant in a 2-month old infant with AT deficiency undergoing stent placement.
Zamora
Rolando
R
Pediatric Cardiology Associates, San Antonio, Texas 78229, USA. zamorasalinas@aol.com
D000925:Anticoagulants / Q000008:administration & dosage*; D000991:Antithrombins / Q000008:administration & dosage* / Q000172:deficiency*; D001778:Blood Coagulation Disorders / Q000150:complications*; D015897:Comorbidity; D004062:DiGeorge Syndrome / Q000150:complications / Q000453:epidemiology; D006629:Hirudins / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011859:Radiography; D011994:Recombinant Proteins / Q000008:administration & dosage; D015607:Stents
D000925:Anticoagulants; D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin