title: Aphasia severity: Association with cerebral perfusion and diffusion.
abstract: BACKGROUND: Previous studies of the relationship between perfusion, diffusion, and stroke suggest that the extent of cerebral hypoperfusion may be a better indicator of neurological status than lesion size in the early phases of recovery. It is not clear how these factors are related to aphasia severity.  AIMS: The purpose of this study was to investigate the relationship between cerebral perfusion, diffusion, and aphasia severity in stroke.  METHODS #ENTITYSTARTX00026; PROCEDURE: Nine participants were examined within 24 hours of stroke onset and six were re-examined at 1 month post stroke. The examination included administration of an aphasia test, a face recognition task, and a neuroimaging session including T2-, perfusion-, and diffusion-weighted MRI.  OUTCOMES #ENTITYSTARTX00026; RESULTS: Participants with a variety of aphasia types and severity were included in the study. Visual inspection suggested larger perfusion abnormality than the actual lesion in eight of nine subjects at day 1. The correlation between aphasia severity and hypoperfusion was significant at day 1 and at 1 month post stroke. However, this was not the case for the relationship between aphasia severity and lesion size where the correlation was not statistically significant at day 1 or at 1 month post stroke.  CONCLUSIONS: These results suggest that cerebral hypoperfusion is a more accurate indicator of aphasia severity in early stroke than lesion volume.
authors.affiliation: University of South Carolina, Columbia, SC, USA.
authors.forename: Julius
authors.initials: J
authors.lastname: Fridriksson
authors.forename: Audrey L
authors.initials: AL
authors.lastname: Holland
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Coull
authors.forename: Elena
authors.initials: E
authors.lastname: Plante
authors.forename: Theodore P
authors.initials: TP
authors.lastname: Trouard
authors.forename: Pelagie
authors.initials: P
authors.lastname: Beeson