The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats.
We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context- and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking.
Bossert
Jennifer M
JM
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. jbossert@intra.nida.nih.gov
Poles
Gabriela C
GC
Sheffler-Collins
Sean I
SI
Ghitza
Udi E
UE
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D016739:Behavior, Addictive / Q000503:physiopathology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D012054:Reinforcement, Psychology; D012646:Self Administration; D013395:Sucrose / Q000008:administration & dosage
D000596:Amino Acids; D019086:Bridged Bicyclo Compounds, Heterocyclic; C118218:LY 379268; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; D013395:Sucrose