title: No association of G72 and D-amino acid oxidase genes with schizophrenia.
abstract: The genes of D-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-D-aspartate receptor regulation pathway for schizophrenia. In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia. In SNP-based single locus association analyses, neither G72 nor DAAO showed significant association with schizophrenia. Additionally, a three-SNP haplotype in DAAO, and a four-SNP as well as a two-SNP haplotype in G72, showed no significant associations with schizophrenia. These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample.
authors.affiliation: Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan.
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Cathy Shen-Jang
authors.initials: CS
authors.lastname: Fann
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Chien Ching
authors.initials: CC
authors.lastname: Chang
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Shih-Kai
authors.initials: SK
authors.lastname: Liu
authors.forename: Ming H
authors.initials: MH
authors.lastname: Hsieh
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chan
authors.forename: Jiahn-Jyh
authors.initials: JJ
authors.lastname: Chen
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D003605:D-Amino-Acid Oxidase / Q000235:genetics* / Q000378:metabolism*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013624:Taiwan
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D003605:D-Amino-Acid Oxidase