[Prevention and treatment of hepatitis B virus reinfection after liver transplantation].
OBJECTIVE
To investigate the risk factors and treatment of hepatitis B virus (HBV) reinfection after liver transplantation.


METHODS
Patients with HBV related end-stage liver disease underwent liver transplantation in our center, and received the combination of intramuscular hepatitis B virus immunoglobulin and oral lamivudine as prophylaxis for HBV reinfection. HBV reinfection cases were monitored after the transplantation.


RESULTS
HBsAg disappeared and HBsAb was detectable in 128 of total 130 patients. The median follow-up period was 12.2 months after transplantation. Eight patients developed HBV reinfection. The recurrence rate of HBV was 6.3%. The reinfection risks were 14.3% and 4.0% respectively among patients with serum HBeAg positive and negative before transplantation (P < 0.05). Among patients with serum HBsAg positive and negative at the first day after liver transplantation, the reinfection risks were 21.1% and 3.7% respectively (P < 0.05).


CONCLUSIONS
Combination of intramuscular HBIg and Lamivudine as prophylaxis of HBV reinfection is effective. HBeAg positive before liver transplantation and HBsAg positive at the first day after transplantation are risk factors of HBV reinfection.
Lu
Min-qiang
MQ
Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-Sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou 510630, China.
Cai
Chang-jie
CJ
Zhao
Hui
H
Yang
Yang
Y
Chen
Gui-hua
GH
D000998:Antiviral Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006801:Humans; D007116:Immunization, Passive; D019259:Lamivudine / Q000627:therapeutic use*; D016031:Liver Transplantation; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D055502:Secondary Prevention; D013997:Time Factors
D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D019259:Lamivudine