title: [Prognostic significance of the hepatopulmonary syndrome in liver cirrhosis].
abstract: OBJECTIVE
  The prognosis of hepatopulmonary syndrome (HPS) has been only rarely investigated.
  
  
  METHODS
  We investigated the survival of 32 cirrhotic patients, 14 (44%) with HPS and 18 with a normal gaseous exchange (NGE), and the associated factors.
  
  
  RESULTS
  During a mean (standard deviation) of 56 (27) months, 9 patients in the HPS group (relative risk: 0.64) and 4 patients in the NGE group (relative risk: 0.22) died. The odds ratio was 6.42 (p < 0.01; 95% confidence interval, 0.04-0.80). Patients in the HPS group died after 44 (31) months, while patients in the NGE group died 65 (21) months after inclusion (p < 0.05). Overall, 46% of deaths were liver related. Factors associated with death were the right to left shunting and the increased plasmatic renin levels. Of note, the plasmatic volume and diffusing capacity were protective.
  
  
  CONCLUSIONS
  The coexistence of HPS worsens the prognosis in liver cirrhosis.
authors.affiliation: Servicio de Medicina Interna, Hospital de Navarra, Pamplona, 31180 Cizur Mayor, Navarre, Spain. jalonsom@cfnavarra.es
authors.forename: José Luis
authors.initials: JL
authors.lastname: Alonso Martínez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Zozaya Urmeneta
authors.forename: Jorge
authors.initials: J
authors.lastname: Gutiérrez Dubois
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Abinzano Guillén
authors.forename: Miren Aránzazu
authors.initials: MA
authors.lastname: Urbieta Echezarreta
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Anniccherico Sánchez
mesh_terms: D005260:Female; D020065:Hepatopulmonary Syndrome / Q000150:complications* / Q000401:mortality; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis