title: Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis.
abstract: NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. In this report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailed kinetic and structural analyses and highlight important differences, which could be exploited for the design of novel selective antimicrobial drugs.
authors.affiliation: Istituto di Biotecnologie Biochimiche, Università Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy. magnig@univpm.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Magni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Orsomando
authors.forename: Nadia
authors.initials: N
authors.lastname: Raffaelli
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009249:NADP / Q000096:biosynthesis*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D009249:NADP; D017853:Phosphotransferases (Alcohol Group Acceptor); C021844:NAD kinase