Future directions of failed implantation and recurrent miscarriage research.
Recurrent implantation failure is today the major reason for women completing several IVF/intracytoplasmic sperm injection attempts without having achieved a child, and is probably also the explanation for many cases of unexplained infertility. Most causes of recurrent miscarriage are still poorly elucidated, but from a theoretical point of view recurrent implantation failure and recurrent miscarriage are suggested to have partly overlapping causes. Recent research has indeed documented that both syndromes can be caused by the same embryonic chromosomal abnormalities and the same maternal endocrine, thrombophilic and immunological disturbances. Consequently, many treatments attempting to normalize these abnormalities have been tested or are currently used in women with both recurrent implantation failure and recurrent miscarriage. However, no treatment for the two syndromes is at the moment sufficiently documented to justify its routine use. In this review, an overview is given regarding present knowledge about causes that may be common for recurrent implantation failure and recurrent miscarriage, and suggestions are put forward for future research that may significantly improve understanding and treatment options for the syndromes.
Christiansen
Ole B
OB
Fertility Clinic 4071, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. obc@pregnancyloss.dkk
Nielsen
Henriette S
HS
Kolte
Astrid M
AM
D000026:Abortion, Habitual / Q000209:etiology / Q000473:pathology / Q000628:therapy; D000818:Animals; D001323:Autoantibodies / Q000378:metabolism; D002869:Chromosome Aberrations; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D010064:Embryo Implantation; D004715:Endometriosis / Q000150:complications; D005260:Female; D006801:Humans; D007125:Immunogenetics; D007167:Immunotherapy; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology / Q000628:therapy; D007694:Killer Cells, Natural / Q000276:immunology; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011110:Polymorphism, Genetic; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D012106:Research / Q000639:trends; D019851:Thrombophilia / Q000150:complications; D017211:Treatment Failure; D014599:Uterus / Q000473:pathology
D001323:Autoantibodies; D016207:Cytokines; D007986:Luteinizing Hormone