Autologous stem cell transplantation and IgM amyloidosis.
High dose chemotherapy (HDC) followed by autologous stem cell transplant (ASCT) is an accepted form of treatment for patients with AL amyloidosis. The purpose of the current study is to review the outcomes of IgM AL amyloidosis patients treated with high dose chemotherapy and autologous stem cell transplant and compare them to the outcomes of all AL amyloidosis subtypes treated similarly. We retrospectively reviewed the pretransplant characteristics, conditioning regimens and response to transplant of all twelve IgM AL amyloidosis patients who were transplanted at the Mayo Clinic between May 1999 and August 2005. Transplant related mortality was low at 8%. The overall hematologic response rate was 89%. The organ response rate was 67%. Overall median survival has not been reached as eleven patients are still alive. IgM AL amyloidosis patients appear to have similar outcomes after HDC and ASCT as other subtypes of AL amyloidosis suggesting that this therapy is an acceptable form of treatment for patients with IgM amyloidosis, and should be considered as a first line treatment option.
Valente
Maria
M
Mayo Clinic, Jacksonville, Florida, USA.
Roy
Vivek
V
Lacy
Martha Q
MQ
Dispenzieri
Angela
A
Gertz
Morie A
MA
D000368:Aged; D000686:Amyloidosis / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome
D007075:Immunoglobulin M