MIB-1 labelling indices according to clinico-pathological variables in canine mammary tumours: a multivariate study.
The relationship between MIB-1 labelling indices (LI), as detected by immunohistochemical methods, and other clinico-pathological characteristics was studied in a series of 77 malignant mammary tumours surgically removed from 47 female dogs. The immunostaining was assessed on the basis of the estimated percentage of positive cells in the areas of highest labelling. Multivariate logistic regression demonstrated no influence of breed, age, previous pregnancies, previous progestin administration, histological type or location of the tumour on MIB-1 LI. MIB-1 LI was significantly related to the size of the tumour, necrosis, invasive growth and histological grade, but not with ulceration, lymph node metastasis, skin fixation or E-cadherin expression. The significant relationship between MIB-1 LI and other known factors of poor prognosis suggests that a high LI may have prognostic value in canine malignant mammary tumours.
De Matos
Augusto José Ferreira
AJ
Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), University of Porto, Largo Professor Abel Salazar, 2, 4099-003, Porto, Portugal.
Lopes
Célia Cristina Carreiras
CC
Faustino
Augusto Manuel Rodrigues
AM
Carvalheira
Júlio Gil Vale
JG
Dos Santos
Marta Susana Amaro
MS
Rutteman
Gerard Röels
GR
Gärtner
Maria de Fátima Rodrigues Moutinho
Mde F
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D016015:Logistic Models; D008207:Lymphatic Metastasis; D015674:Mammary Neoplasms, Animal / Q000378:metabolism / Q000473:pathology*; D015999:Multivariate Analysis; D009367:Neoplasm Staging
D019394:Ki-67 Antigen