title: [Micafungin therapy for a case of chronic necrotizing pulmonary aspergillosis].
abstract: The patient was a 42-year-old man who visited a physician with fever, and was diagnosed with pulmonary abscess. Antibiotic therapy was ineffective, and he was referred to our hospital. Chest CT scanning revealed a lesion with cavity formation with an infiltrative shadow in the right upper lobe, and another infiltrative shadow in the left upper lobe. Chronic necrotizing pulmonary aspergillosis (CNPA) was diagnosed on the basis of positive culture of bronchial lavage specimens and positive serological test results for Aspergillus, in addition to the clinical and radiographic features. Intravenous administration of micafungin (MCFG) was initiated with combination therapy of percutaneous cavity drainage, inhaled amphotericin B and oral itraconazole. Clinical symptoms and findings gradually improved, and he was discharged after 40 days of MCFG therapy. MCFG was safe and effective therapy in this case, and may be considered a new therapeutic option for CNPA.
authors.affiliation: Department of Respiratory Medicine, Toyota Memorial Hospital.
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Sugino
authors.forename: Michiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Motoaki
authors.initials: M
authors.lastname: Kato
authors.forename: Ayako
authors.initials: A
authors.lastname: Yagi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawabata
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D054714:Echinocandins; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage*; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D000077551:Micafungin; D009336:Necrosis; D010456:Peptides, Cyclic / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D017964:Itraconazole; D000666:Amphotericin B; D000077551:Micafungin