[Spontaneously acquired haemophilia: report of a patient with prostatic adenoma].
We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.
Barrier
F
F
Pharmacie Centrale, Centre Hospitalier de Dunkerque.
de La Guerenne
A
A
Semjen
E
E
Wierre
L
L
Horrent
S
S
Decaudin
B
B
Resibois
J P
JP
Weillaert
M P
MP
Azar
R
R
Odou
P
P
D000236:Adenoma / Q000150:complications*; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis; D006406:Hematoma; D006467:Hemophilia A / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000150:complications*; D014227:Triazines
D014227:Triazines; C053507:4-azido-7-phenylpyrazolo-(1,5a)-1,3,5-triazine; D005169:Factor VIII; D017430:Prostate-Specific Antigen