[A study of the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome and obesity and patients with normal body mass].
OBJECTIVE
To explore the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and obesity and patients with normal body mass.


METHODS
Polysomnography (PSG) was performed in 53 patients with OSAHS and in 41 simple obesity and in 62 patients with normal body mass. The level of serum leptin was detected by radioimmunoassay. The stature, weight, neck collar, hip circumference, waistline were measured.


RESULTS
(1) Serum leptin level in patients with OSAHS and obesity was higher than patients with normal body mass. At the same time, serum leptin level in patients with OSAHS was higher than obesity ( P < 0.05). (2) Serum leptin levels were positive significantly correlated with BMI in both OSAHS patients and simple obesity, but only the leptin level in patients with OSAHS was significantly correlated with apnea and hypopnea index (AHI) and proportion of neck circumference and waist-hip ratio (WHR).


CONCLUSIONS
The rise of the serum leptin level in obesity was resisted of leptin. The serum leptin level of patients with OSAHS correlated with AHI shows that OSAHS maybe one reason of arising serum leptin's rising. Leptin could stimulate aspirator centrum.
Wang
Shengguo
S
Department of Otolaryngology, the 105th Hospital of the PLA, Hefei, China. wangsg105@sina.com
Zhou
Benzhong
B
Sun
Jingwu
J
Xu
Weiqing
W
Jiang
Zhikui
Z
Lan
Lan
L
Yu
Hongyan
H
D000328:Adult; D000368:Aged; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications
D020738:Leptin