title: [Methods for identification of cancer genes].
abstract: Through classical genetic epidemiological studies, such as twin studies, it is possible to get an estimate of the genetic contribution to cancer risk. However, due to the high degree of complexity of the human genome, it is not an easy task to identify the genes responsible for this contribution. Linkage analysis in cancer families has allowed the localisation and subsequent identification of highly penetrant cancer genes. For the identification of weaker susceptibility genes, association studies have been and will in the coming years increasingly be used.
authors.affiliation: Odense Universitetshospital, Afdeling for Biokemi, Farmakologi og Genetik, DK-5000 Odense C. torben.kruse@ouh.fyns-amt.dk
authors.forename: Torben A
authors.initials: TA
authors.lastname: Kruse
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D052138:Genes, Neoplasm / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein