title: Building up linguistic context in schizophrenia: evidence from self-paced reading.
abstract: An impairment in the build-up and use of context has been proposed as a core feature of schizophrenia. The current study tested the hypothesis that schizophrenia patients show impairments in building up context within sentences because of abnormalities in combining semantic with syntactic information. Schizophrenia patients and healthy controls read and made acceptability judgments about sentences containing verbs that were semantically associated with individual preceding words but that violated either the meaning (animacy/semantic constraints) or the syntactic structure (morphosyntactic constraints) of their preceding contexts. To override these semantic associations and determine that such sentences are unacceptable, participants must integrate semantic with syntactic information. These sentences were compared with congruous and pragmatically/semantically violated sentences that imposed fewer semantic-syntactic integration demands. At sentence-final words and decisions, patients showed smaller reaction time differences than controls to animacy/semantically violated or morphosyntactically violated sentences relative to pragmatically/semantically violated or nonviolated sentences. The relative insensitivity to these violations in patients with schizophrenia may arise from impairments in combining semantic and syntactic information to build up sentence context.
authors.affiliation: Department of Psychology, Tufts University, and Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA. kuperber@nmr.mgh.harvard.edu
authors.forename: Gina R
authors.initials: GR
authors.lastname: Kuperberg
authors.forename: Donna A
authors.initials: DA
authors.lastname: Kreher
authors.forename: Donald
authors.initials: D
authors.lastname: Goff
authors.forename: Philip K
authors.initials: PK
authors.lastname: McGuire
authors.forename: Anthony S
authors.initials: AS
authors.lastname: David
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011578:Psycholinguistics; D011930:Reaction Time / Q000502:physiology; D011932:Reading; D012559:Schizophrenia / Q000503:physiopathology*; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D012660:Semantics