title: Antioedematogenic effect of marrubiin obtained from Marrubium vulgare.
abstract: This paper describes the antioedematogenic profile of marrubiin (1), the main constituent of Marrubium vulgare, a medicinal plant used in folk medicine of several countries to treat different pathologies. Compound (1) was analyzed in a model of microvascular leakage in mice ears. The results show that it exhibits significant and dose-related antioedematogenic effects. The results obtained for ID50 values (mg/kg, i.p.) and maximal inhibition (%) for the different phlogistic agents used were as follows: histamine (HIS, 13.84 mg/kg and 73.7%); (BK, 18.82 mg/kg and 70.0%); carrageenan (CAR, 13.61 mg/kg and 63.0%). The other phlogistic agonists, such as prostaglandin E2 (PGE2), caused inhibition of less than 50%. In addition, (1) (100 mg/kg) significantly inhibited the OVO-induced allergic edema in actively sensitized animals (maximal inhibition 67.6+/-4%). Our results demonstrate that the systemic administration of marrubiin exerts a non-specific inhibitory effect on pro-inflammatory agent-induced microvascular extravasation of Evans blue in mouse ear.
authors.affiliation: Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil.
authors.forename: Hellen K
authors.initials: HK
authors.lastname: Stulzer
authors.forename: Monika P
authors.initials: MP
authors.lastname: Tagliari
authors.forename: Julio A
authors.initials: JA
authors.lastname: Zampirolo
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel-Filho
authors.forename: Valfredo
authors.initials: V
authors.lastname: Schlemper
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002351:Carrageenan / Q000633:toxicity; D003907:Dexamethasone / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006632:Histamine / Q000633:toxicity; D008297:Male; D027522:Marrubium / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010936:Plant Extracts; D003907:Dexamethasone; D006632:Histamine; D002351:Carrageenan; C105731:marrubiin