title: Risk factors and stroke subtypes: results of five consecutive years of the Perugia Stroke Registry.
abstract: To understand the etiopathogenetic mechanisms of stroke and to target prevention, we need to know how risk factors differ among etiological subtypes. Our aims were to determine the different profile of risk factors for ischemic and hemorrhagic stroke subtypes in our cohort from the Perugia Hospital-Based Stroke Registry. We analyzed the characteristics and the different risk factors of 2,395 first-ever consecutive stroke patients admitted to the Perugia Hospitals in the period between January 1, 1998 and December 31, 2002. The prevalence of cerebrovascular risk factors in each stroke subtype was analyzed independently and compared with other subtypes of stroke pooled together by means of univariate analysis and logistic regression models. Hypertension occurred in 61% of patients; familial history of stroke in 41.6%; vascular disease in 27.2%; embolic heart disease in 22.3%; cigarette smoking in 21.6%. Different potentially modifiable risk factors profiles were identified for each ischemic subtype of stroke, while in hemorrhagic lobar stroke subtypes, only male gender was an independent risk factor.
authors.affiliation: Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy. silvestrelli@tin.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Silvestrelli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Paciaroni
authors.forename: Valeria
authors.initials: V
authors.lastname: Caso
authors.forename: Paolo
authors.initials: P
authors.lastname: Milia
authors.forename: Francesco
authors.initials: F
authors.lastname: Palmerini
authors.forename: Michele
authors.initials: M
authors.lastname: Venti
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D020521:Stroke / Q000145:classification / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors; D014505:Urban Population; D014652:Vascular Diseases / Q000150:complications* / Q000453:epidemiology