The genetic basis of tooth development and dental defects.
More than 300 genes have so far been associated with tooth development, mainly in mouse embryos. The majority of them are associated with conserved signaling pathways mediating cellular communication, in particular between epithelial and mesenchymal tissues. Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes.
Thesleff
Irma
I
Institute of Biotechnology, University of Helsinki, Helsinki, Finland. irma.thesleff@helsinki.fi
D000818:Animals; D003744:Dental Enamel Hypoplasia / Q000235:genetics; D004476:Ectodermal Dysplasia / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009024:Morphogenesis; D009805:Odontogenesis / Q000235:genetics*; D015398:Signal Transduction; D014070:Tooth / Q000196:embryology / Q000254:growth & development*; D014071:Tooth Abnormalities / Q000196:embryology / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors