Synthesis of 2,4-disubstituted 5-aminoimidazoles using microwave irradiation.
A microwave-assisted parallel synthesis of 2,4-disubstituted 5-aminoimidazoles has been developed. Significant rate enhancement was observed for all steps in the three-step protocol. The overall reaction time was shortened to 25 min, as compared to 53 h for the conventional procedures. A representative set of 2,4-disubstituted 5-aminoimidazoles was prepared using commercially available parallel reactors.
Soh
Chai Hoon
CH
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chui
Wai Keung
WK
Lam
Yulin
Y
D020650:Combinatorial Chemistry Techniques; D007191:Indazoles / Q000138:chemical synthesis*; D008872:Microwaves; D008956:Models, Chemical; D015394:Molecular Structure
D007191:Indazoles; C014974:5-aminoindazole