A GAP in convergent extension scores PAR.
The process of "convergence and extension" regulates cellular intercalation during gastrulation. An ArfGAP-PAR protein complex is required for the associated cellular polarization. Potential interactions between this complex and relevant planar cell polarity factors in this context are discussed.
Mlodzik
Marek
M
Brookdale Department of Molecular, Cell & Developmental Biology, Mt. Sinai School of Medicine, Annenberg Building 18-92, One Gustave L. Levy Place, New York, New York 10029, USA.
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology; D004330:Drosophila / Q000196:embryology / Q000502:physiology; D020690:GTPase-Activating Proteins / Q000502:physiology*; D005775:Gastrula / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D014981:Xenopus / Q000196:embryology / Q000502:physiology
D002352:Carrier Proteins; D020690:GTPase-Activating Proteins