Gomisin A improves scopolamine-induced memory impairment in mice.
Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test (P<0.05), and also improved escape latency in the Morris water maze test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.
Kim
Dong Hyun
DH
Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, #1 Hoeki-dong, Dongdeamoon-ku, Seoul 130-701, South Korea.
Hung
Tran Manh
TM
Bae
Ki Hwan
KH
Jung
Ji Wook
JW
Lee
Seungjoo
S
Yoon
Byung Hoon
BH
Cheong
Jae Hoon
JH
Ko
Kwang Ho
KH
Ryu
Jong Hoon
JH
D000110:Acetylcholinesterase / Q000378:metabolism; D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects; D034242:Cyclooctanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D012601:Scopolamine / Q000633:toxicity*
D002800:Cholinesterase Inhibitors; D034242:Cyclooctanes; D004149:Dioxoles; D004365:Drugs, Chinese Herbal; D017705:Lignans; C033585:schizandrol B; D012601:Scopolamine; D000110:Acetylcholinesterase