Cell-autonomous and -nonautonomous contributions of STAT1 in murine models of tumorigenesis.
In this issue of Cancer Cell, Kovacic and colleagues have reexamined the role of STAT1 in murine models of leukemogenesis. Their studies shed new light on the complex interplay between cell-autonomous contributions and host responsiveness to cancer and elucidate a previously unknown role of STAT1 in tumor progression.
Rocnik
Jennifer L
JL
Howard Hughes Medical Institute, Harvard Medical School, Karp Family Research Laboratories, 1 Blackfan Circle, Room 5210, Boston, Massachusetts 02115,USA.
Gilliland
D Gary
DG
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D007942:Leukemia, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D015395:Histocompatibility Antigens Class I; C499308:Rag2 protein, mouse; D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse