title: Further experience with laparoscopic nephrectomy for Wilms' tumour after chemotherapy.
abstract: OBJECTIVE
  To report the results of laparoscopic nephrectomy for unilateral Wilms' tumour in children treated with chemotherapy before surgery.
  
  
  METHODS
  Eight children with unilateral nonmetastatic Wilms' tumour included in the International Society of Pediatric Oncology 2001 protocol were treated with vincristine/actinomycin D and then had laparoscopic nephrectomy and lymph-node sampling. A Veress needle puncture was made and a four-trocar transperitoneal approach was used in all cases. The tumour was extracted with no morcellation through a Pfannenstiel incision.
  
  
  RESULTS
  All eight tumours were completely removed, with lymph node samples; intraoperative bleeding was minimal (50 mL). There were no complications after surgery and patients were discharged after 2-3 days. No recurrences of disease, port-site implantation or long-term complications were detected.
  
  
  CONCLUSIONS
  Laparoscopic nephrectomy for unilateral Wilms' tumour is feasible in children after chemotherapy; it is safe and allows the complete surgical approach required for treating this tumour. Although the patients had a good long-term follow-up, more patients are needed to compare the results of laparoscopic techniques with open surgery.
authors.affiliation: Department of Urology, University of São Paulo Medical School, São Paulo, Brazil. ricjordao@uol.com.br
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Duarte
authors.forename: Francisco T
authors.initials: FT
authors.lastname: Dénes
authors.forename: Lilian M
authors.initials: LM
authors.lastname: Cristofani
authors.forename: Vicente
authors.initials: V
authors.lastname: Odone-Filho
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016063:Blood Loss, Surgical; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D009392:Nephrectomy / Q000379:methods*; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy / Q000601:surgery*
chemical_list: D014750:Vincristine