Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer.
The availability of new cell culture, cell transplantation, and gene expression technology has highlighted a role of hepatocytes as facultative stem cells for the biliary epithelium. In addition, hepatocytes can revert to primitive progenitor cell types and express gene profiles that appear as characteristic "signatures" in hepatocellular carcinomas.
Michalopoulos
George K
GK
Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. michalopoulosgk@upmc.edu
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D019070:Cell Lineage; D049109:Cell Proliferation; D022781:Hepatocytes / Q000166:cytology* / Q000473:pathology*; D009940:Organoids; D013234:Stem Cells / Q000378:metabolism