A convergent synthetic study of biologically active benzofuran derivatives.
In order to construct a benzofuran library, we developed a model study of benzbromarone. Synthesis has been achieved in 53% overall yield, starting from phenol via the key intermediate 2-ethylbenzofuran which was afforded by intramolecular Wittig reaction.
Hu
Kun
K
College of Pharmacy, Kyung Hee University, Seoul, Korea.
Jeong
Jin-Hyun
JH
D001553:Benzbromarone / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D014528:Uricosuric Agents / Q000138:chemical synthesis*
D001572:Benzofurans; D014528:Uricosuric Agents; D001553:Benzbromarone