The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint.
How complex body plans evolved in animals such as fruit flies and vertebrates, as compared to the relatively simple jellyfish and sponges, is not known, given the similarity of developmental genetic repertoires shared by all these taxa. Here, we show that a core set of 18 microRNAs (miRNAs), non-coding RNA molecules that negatively regulate the expression of protein-coding genes, are found only in protostomes and deuterostomes and not in sponges or cnidarians. Because many of these miRNAs are expressed in specific tissues and/or organs, miRNA-mediated regulation could have played a fundamental evolutionary role in the origins of organs such as brain and heart--structures not found in cnidarians or sponges--and thus contributed greatly to the evolution of complex body plans. Furthermore, the continuous acquisition and fixation of miRNAs in various animal groups strongly correlates both with the hierarchy of metazoan relationships and with the non-random origination of metazoan morphological innovations through geologic time.
Sempere
Lorenzo F
LF
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
Cole
Charles N
CN
McPeek
Mark A
MA
Peterson
Kevin J
KJ
D000818:Animals; D001483:Base Sequence; D002816:Chordata, Nonvertebrate / Q000235:genetics*; D016000:Cluster Analysis; D019295:Computational Biology; D019143:Evolution, Molecular; D006801:Humans; D007448:Invertebrates / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014714:Vertebrates / Q000235:genetics*
D035683:MicroRNAs