title: [Epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome].
abstract: OBJECTIVE
  To carry out an epidemiological study of clinical characteristics of Chinese Han ethnic women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  According to Revised 2003 European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria, PCOS can be diagnosed with 2 manifestations out of oligo-or anovulation, clinical and/or biochemical signs of hyperandrogenism exclusion of other etiologies and polycystic ovaries. One thousand and twenty-seven women in reproductive age from one area in Jinan city were investigated and the clinical, metabolic characteristics of the PCOS patients were analyzed.
  
  
  RESULTS
  (1) A total of 828 questionnaires were collected from 1027 women; the response rate was 80.62%. Eighty-five PCOS patients were diagnosed; PCOS accounted for 97.65% (83/85) in <or= 35 years old population groups; (2) Clinical manifestations were different between PCOS groups and controls in each age stage (P < 0.05); Menstruation, body hair Ferriman-Gallny (F-G) score, acne, ovarian follicle numbers decreased with aging among PCOS groups, and menstruation cycle was longer, testosterone (T), free androgen index (FAI) and ovarian follicle numbers were higher, sex hormone-binding globulin (SHBG) was lower than control groups of the same age respectively (P < 0.01); (3) Homeostasis model assessment-insulin resistance (Homa-IR) index in infertility PCOS group was higher than in fertility group (1.49 +/- 0.73 vs 1.31 +/- 0.66; t = 2.058; P < 0.05); fasting insulin, fasting blood glucose in obesity PCOS group was higher than in non-obesity group (8.50 +/- 3.46 vs 5.7 +/- 2.3, t = 2.984; P < 0.01, 5.45 +/- 0.54 vs 4.88 +/- 0.45, t = 2.891; P < 0.01), in contrast, insulin sensitivity index was lower in obesity PCOS group than in non-obesity group (0.025 +/- 0.015 vs 0.044 +/- 0.026; t = 2.292, P < 0.05).
  
  
  CONCLUSIONS
  (1) PCOS mainly distributes in <or= 35 years old population; (2) clinical manifestations of oligo-ovulation, clinical and/or biochemical signs of hyperandrogenism, polycystic ovaries of PCOS change with age increase. (3) PCOS with infertility and obesity is usually associated with glucose metabolic changes, especially insulin resistance.
authors.affiliation: Reproductive Medicine Center, Shandong Provincial Hospital, Shandong University, Ji'nan 250021, China.
authors.forename: Jun-li
authors.initials: JL
authors.lastname: Zhao
authors.forename: Zi-jiang
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Geng
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Gao
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Feng-rong
authors.initials: FR
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008597:Menstrual Cycle; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000208:ethnology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone