Distant metastasis of prostate cancer: early detection of recurrent tumor with dual-phase carbon-11 choline positron emission tomography/computed tomography in two cases.
Several types of recurrence may be detected by radiologic assessment after treatment in patients with prostate cancer. However, early detection of distant metastasis using positron emission tomography has so far never been published. We report two patients who underwent hormone therapy or surgical resection for prostate cancer. They developed distant metastases which were detected on whole body [C-11] choline positron emission tomography/computed tomography with significant elevation of serum PSA level. In one patient, recurrent tumor of the supraclavicular node (6 mm) diminished in size after subsequent hormone therapy. Surgical resection of recurrent tumor of the lung (12 mm) was performed in the other patient, the pathology of which confirmed the metastatic adenocarcinoma derived from the prostate. The recurrent tumor can be correctly detected by dual-phase whole body [C-11] choline positron emission tomography/computed tomography.
Maeda
Tetsuo
T
Division of Diagnostic Radiology, National Cancer Center Hospital, Chuo-ku 104-0045, Tokyo, Japan.
Tateishi
Ukihide
U
Komiyama
Motokiyo
M
Fujimoto
Hiroyuki
H
Watanabe
Shun-Ichi
S
Terauchi
Takashi
T
Moriyama
Noriyuki
N
Arai
Yasuaki
Y
Sugimura
Kazuro
K
Kakizoe
Tadao
T
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002250:Carbon Radioisotopes; D002794:Choline; D042241:Early Diagnosis; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D049268:Positron-Emission Tomography; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D018931:Antineoplastic Agents, Hormonal; D002250:Carbon Radioisotopes; D017430:Prostate-Specific Antigen; D002794:Choline