title: Efficacy and safety of gatifloxacin for urinary tract infection in nonspecialized Korean urologic practice.
abstract: To investigate the efficacy and safety of gatifloxacin (400mg/day) on chronic prostatitis or cystitis, 453 patients with prostatitis (NIH category II or IIIa) (N=149, mean 45.8+/-13.3 years) and cystitis (N=304, mean 53.8+/-14.3 years) were enrolled. Total NIH CPSI score and symptom score for cystitis decreased from 20.3 to 9.9 (response rate 86.7%, 95% CI 80.2-93.2%) and from 6.2 to 1.8 (response rate 83.2%, 95% CI 78.7-87.7%), respectively. In the overall clinical efficacy, 71.2% and 88.4% of the patients with prostatitis and cystitis were responders, respectively. Of the patients, 15.7% reported insignificant adverse events. These results suggest that gatifloxacin was well tolerated and improved the clinical outcomes in patients with chronic prostatitis or cystitis.
authors.affiliation: Department of Urology, Pusan National University Hospital, 1-10 Ami-dong, Seo-gu, Busan, South Korea.
authors.forename: Sang Don
authors.initials: SD
authors.lastname: Lee
authors.forename: Seung Ju
authors.initials: SJ
authors.lastname: Lee
authors.forename: Tae Kon
authors.initials: TK
authors.lastname: Hwang
authors.forename: Duck Ki
authors.initials: DK
authors.lastname: Yoon
authors.forename: Kyu Sung
authors.initials: KS
authors.lastname: Lee
authors.forename: Luck Hee
authors.initials: LH
authors.lastname: Sung
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Choo
authors.forename: Bong Suk
authors.initials: BS
authors.lastname: Shim
authors.forename: In Rae
authors.initials: IR
authors.lastname: Cho
authors.forename: Min Eui
authors.initials: ME
authors.lastname: Kim
authors.forename: Soo Bang
authors.initials: SB
authors.lastname: Ryu
authors.forename: Chul Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Young Gon
authors.initials: YG
authors.lastname: Kim
authors.forename: Chun Il
authors.initials: CI
authors.lastname: Kim
authors.forename: Hyun Yul
authors.initials: HY
authors.lastname: Rhew
authors.forename: Myung Hoon
authors.initials: MH
authors.lastname: Kim
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003556:Cystitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use*; D000077734:Gatifloxacin; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D011472:Prostatitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D024841:Fluoroquinolones; D000077734:Gatifloxacin