title: pH-induced intracellular protein transport.
abstract: A new mechanism of selective transport and localization of proteins inside any living cell is presented. The mechanism is based on pH-induced protein trapping. It is shown that spontaneous and unique spatial redistribution of different proteins is possible in any aqueous solution with stable non-uniform distribution of H(+) ions. This phenomenon was observed in artificial systems with fixed non-uniform pH distribution and in living cells.
authors.affiliation: Technion-Israel Institute of Technology, Solid State Institute, 32000 Haifa, Israel.
authors.forename: E M
authors.initials: EM
authors.lastname: Baskin
authors.forename: S
authors.initials: S
authors.lastname: Bukshpan
authors.forename: G V
authors.initials: GV
authors.lastname: Zilberstein
mesh_terms: D000818:Animals; D003720:Densitometry; D005782:Gels; D049452:Green Fluorescent Proteins; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D010798:Phycocyanin / Q000737:chemistry / Q000378:metabolism; D040081:Protein Array Analysis; D021381:Protein Transport
chemical_list: D005782:Gels; D009211:Myoglobin; D010798:Phycocyanin; D049452:Green Fluorescent Proteins; D009113:Muramidase