title: Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating.
abstract: Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-beta signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Grimm
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Rosen
mesh_terms: D000818:Animals; D001940:Breast / Q000166:cytology / Q000378:metabolism*; D002417:Cattle; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000502:physiology*; D047628:Estrogen Receptor alpha / Q000502:physiology*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D051381:Rats; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
chemical_list: D047628:Estrogen Receptor alpha; D016212:Transforming Growth Factor beta