title: Curation of complex, context-dependent immunological data.
abstract: BACKGROUND
  The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http://www.immuneepitope.org.
  
  
  METHODS
  To identify and extract relevant data from the scientific literature in an efficient and accurate manner, novel processes were developed for manual and semi-automated annotation.
  
  
  CONCLUSIONS
  Formalized curation strategies enable the processing of a large volume of context-dependent data, which are now available to the scientific community in an accessible and transparent format. The experiences described herein are applicable to other databases housing complex biological data and requiring a high level of curation expertise.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California, USA. rvita@liai.org
authors.forename: Randi
authors.initials: R
authors.lastname: Vita
authors.forename: Kerrie
authors.initials: K
authors.lastname: Vaughan
authors.forename: Laura
authors.initials: L
authors.lastname: Zarebski
authors.forename: Nima
authors.initials: N
authors.lastname: Salimi
authors.forename: Ward
authors.initials: W
authors.lastname: Fleri
authors.forename: Howard
authors.initials: H
authors.lastname: Grey
authors.forename: Muthu
authors.initials: M
authors.lastname: Sathiamurthy
authors.forename: John
authors.initials: J
authors.lastname: Mokili
authors.forename: Huynh-Hoa
authors.initials: HH
authors.lastname: Bui
authors.forename: Philip E
authors.initials: PE
authors.lastname: Bourne
authors.forename: Julia
authors.initials: J
authors.lastname: Ponomarenko
authors.forename: Romulo
authors.initials: R
authors.lastname: de Castro
authors.forename: Russell K
authors.initials: RK
authors.lastname: Chan
authors.forename: John
authors.initials: J
authors.lastname: Sidney
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Wilson
authors.forename: Scott
authors.initials: S
authors.lastname: Stewart
authors.forename: Scott
authors.initials: S
authors.lastname: Way
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
mesh_terms: D000486:Allergy and Immunology; D000818:Animals; D001185:Artificial Intelligence; D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D016208:Databases, Factual; D030562:Databases, Protein; D000939:Epitopes / Q000737:chemistry*; D006801:Humans; D007107:Immune System; D016247:Information Storage and Retrieval; D015233:Models, Statistical; D010363:Pattern Recognition, Automated
chemical_list: D000939:Epitopes