1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents.
Various acyl groups possessing markedly divergent topography were placed on the nitrogen atom of the antimycobacterial agent 3,5-bis(phenylmethylene)-4-piperidone (1). Some of the N-maleamoyl analogues of 1 displayed antitubercular properties thereby affording an insight into the structural requirements for interactions at a putative auxiliary binding site in the bacterium.
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Department of Chemistry, Acadia University, Canada.
Dimmock
J R
JR
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism; D010881:Piperidones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000995:Antitubercular Agents; D010881:Piperidones