title: Economic evaluation of alternative management methods of first-trimester miscarriage based on results from the MIST trial.
abstract: OBJECTIVE
  To compare the cost-effectiveness of alternative management methods of first-trimester miscarriage.
  
  
  METHODS
  Economic evaluation conducted alongside a large randomised controlled trial (the MIST trial).
  
  
  METHODS
  Early pregnancy assessment units of seven participating hospitals in southern England.
  
  
  METHODS
  A total of 1200 women with a confirmed pregnancy of less than 13 weeks of gestation with a diagnosis of incomplete miscarriage or missed miscarriage.
  
  
  METHODS
  Random allocation to expectant management, medical management or surgical management. Collection of health service and broader resource use data, unit costs for each resource item and clinical outcomes.
  
  
  METHODS
  Costs (pounds, 2001-02 prices) to the health service, social services, women, carers and wider society during the first 8 weeks postrandomisation. Cost-effectiveness estimates, expressed in terms of incremental cost per gynaecological infection prevented; cost-effectiveness acceptability curves presented at alternative willingness-to-pay thresholds for preventing gynaecological infection.
  
  
  RESULTS
  There was no significant difference in the incidence of gynaecological infection between groups. The net societal cost per woman was estimated at 1086.20 pounds in the expectant group, 1410.40 pounds in the medical group and 1585.30 pounds in the surgical group. Expectant management had a 97.8% probability of being the most cost-effective management method at a willingness-to-pay threshold of 10,000 pounds for preventing one gynaecological infection, while medical management had a 2.2% probability of being the most cost-effective management method. Expectant management retained the highest probability of being the most cost-effective management method at all willingness-to-pay thresholds of less than 70,000 pounds for preventing one gynaecological infection.
  
  
  CONCLUSIONS
  Expectant and medical management of first-trimester miscarriage possess significant economic advantages over traditional surgical management.
authors.affiliation: National Perinatal Epidemiology Unit, University of Oxford (Old Road Campus), Headington, Oxford, UK. stavros.petrou@npeu.ox.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Petrou
authors.forename: J
authors.initials: J
authors.lastname: Trinder
authors.forename: P
authors.initials: P
authors.lastname: Brocklehurst
authors.forename: L
authors.initials: L
authors.lastname: Smith
mesh_terms: D000022:Abortion, Spontaneous / Q000191:economics* / Q000628:therapy; D003362:Cost-Benefit Analysis; D004739:England; D005260:Female; D017048:Health Care Costs; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011295:Prenatal Care / Q000191:economics / Q000706:statistics & numerical data