UVA photoirradiation of halogenated-polycyclic aromatic hydrocarbons leading to induction of lipid peroxidation.
Since the finding in the 1930s, a large number of polycyclic aromatic hydrocarbons (PAHs) of different structures have been tested for potential tumorigenicity. Structure-activity relationships of halo-PAHs have been investigated to determine the regions of a PAH that may be involved in cancer initiation. From these studies, a number of halo-PAHs were found to be tumorigenic in experimental animals. It was not until the 1980s that halo- PAHs were found to be present in the environment, including municipal incinerator fly ash, urban air, coal combustion, soil, snow, automobile exhausts, and tap water. Due to their widespread presence in the environment and their genotoxic activities, including carcinogenicity, many of these compounds may pose a health risk to humans. Although the biological activities, including metabolism, mutagenicity, and carcinogenicity, of halo- PAHs have been studied their phototoxicity and photo-induced biological activity have not been well examined. In this study, we study the photoirradiation of a series of structure-related halo-PAHs by UVA light in the presence of a lipid, methyl linoleate, and determine as to whether or not these compounds can induce lipid peroxidation. The halo-PAHs chosen for study include 2-bromonaphthalene, 1-chloroanthracene, 9,10- dibromoanthracene, 9-chlorophenanthrene, 9-bromophenanthrene, 7-chlorobenz[a]anthracene, 7- bromobenz[a]anthracene, 7-bromo-5-methylbenz[a]anthracene, 6-chlorobenzo[a]pyrene, and 6- bromobenzo[a]pyrene. The results indicate that upon photoirradiation by UVA all these compounds induced lipid peroxidation at different levels. These results suggest that halo-PAHs may be harmful to human health.
Herreno-Sáenz
Diógenes
D
Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, P.O. Box 365067, San Juan, Puerto Rico 00936-5067. dherreno@rcm.upr.edu
Xia
Qingsu
Q
Chiu
Li-Ting
LT
Fu
Peter P
PP
D004785:Environmental Pollutants / Q000737:chemistry / Q000528:radiation effects*; D008041:Linoleic Acids / Q000737:chemistry* / Q000528:radiation effects; D015227:Lipid Peroxidation; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004785:Environmental Pollutants; D008041:Linoleic Acids; D011084:Polycyclic Aromatic Hydrocarbons; C005575:methyl linoleate