title: Evaluation of the efficacy of the acellular dermal matrix allograft with partial thickness flap in the elimination of gingival melanin pigmentation. A comparative clinical study with 12 months of follow-up.
abstract: Acellular dermal matrix (ADM) has been used as a substitute for gingival allografts. The aim of this study was to evaluate the effectiveness of ADM with partial thickness flap in the elimination of gingival melanic pigmentations. Fifteen patients presenting bilateral gingival melanin pigmentation were selected for this study. Each side of the pigmentation was randomly assigned to be part of a group. The sites of the experimental group had a partial thickness flap raised, excised, followed by adaptation and suture of the ADM. On the opposite side (ie, sites from the control group), the oral epithelium was removed with a diamond bur. The healing process was evaluated at 1 and 2 weeks, and 1, 3, 6, 9, and 12 months postoperatively. Images of the patient's follow-up were digitalized, and occurrence and quantification of clinical repigmentation were evaluated. After 12 months, minimal repigmentation (mean 3.14 +/- 7.45%) was noted in 8 of 15 sites from the ADM group, while significant repigmentation (mean 55.84 +/- 27.25%) was seen in 15 of 15 abrasion sites. According to our results, it can be concluded that ADM may be successfully used in the elimination or greater reduction of gingival melanic pigmentations, and is more efficient than epithelium abrasion after 12 months (p < 0.0001).
  
  
  CONCLUSIONS
  Gingival pigmentation is a common finding in several ethnic groups. Although physiologic melanin pigmentation is not a medical problem, cosmetic demands may turn it into a problem of social acceptance in different cultures. In this way, different treatment modalities have been used with the aim of removing pigmentations for esthetic reasons. In the present study, the use of ADM with partial thickness flap resulted in more effective elimination of gingival melanin pigmentation, as repigmentation occurred later and was much weaker when compared to the outcomes of epithelial abrasion.
authors.affiliation: Department of Surgery, Oral-Maxillo-Facial Traumatology and Periodontology, University of São Paulo, School of Dentistry of Ribeirão Preto, Ribeirão Preto-Brazil.
authors.forename: Ana E F
authors.initials: AE
authors.lastname: Pontes
authors.forename: Carla C
authors.initials: CC
authors.lastname: Pontes
authors.forename: Sérgio L S
authors.initials: SL
authors.lastname: Souza
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Novaes
authors.forename: Márcio F M
authors.initials: MF
authors.lastname: Grisi
authors.forename: Mário
authors.initials: M
authors.lastname: Taba
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D005260:Female; D005881:Gingiva / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D008543:Melanins; D008875:Middle Aged; D010858:Pigmentation; D017768:Skin, Artificial; D013524:Surgical Flaps
chemical_list: D008543:Melanins