Effect of diazepam on anxiety, sexual motivation, and blood testosterone in anxious male mice.
The effects of diazepam on anxious behavior, sexual motivation, and blood level of testosterone in the presence of a female were studied in male mice with elevated anxiety. Diazepam produced an anxiolytic effect in novel environment, but was ineffective during social contacts. The drug potentiated the primary sexual interest, but failed to correct exhaustion of sexual motivation. The drug produced no effect on blood testosterone.
Amikishieva
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AV
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. amik@bionet.nsc.ru
Semendyaeva
S N
SN
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000188:drug therapy*; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011963:Receptors, GABA-A / Q000378:metabolism; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*
D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D011963:Receptors, GABA-A; D013739:Testosterone; D003975:Diazepam