title: Oral human immunoglobulin for children with autism and gastrointestinal dysfunction: a prospective, open-label study.
abstract: Immunoglobulin secretion onto mucosal surfaces is a major component of the mucosal immune system. We hypothesized that chronic gastrointestinal (GI) disturbances associated with autistic disorder (AD) may be due to an underlying deficiency in mucosal immunity, and that orally administered immunoglobulin would be effective in alleviating chronic GI dysfunction in these individuals. In this pilot study, twelve male subjects diagnosed with AD were evaluated using a GI severity index (GSI) while receiving daily dosing with encapsulated human immunoglobulin. Following eight weeks of treatment, 50% of the subjects met prespecified criteria for response in GI signs and symptoms and showed significant behavioral improvement as assessed by the Autism Behavior Checklist and parent and physician rated Clinical Global Impression of Improvement.
authors.affiliation: Southwest Autism Research and Resource Center, Phoenix, AZ, USA.
authors.forename: Cindy K
authors.initials: CK
authors.lastname: Schneider
authors.forename: Raun D
authors.initials: RD
authors.lastname: Melmed
authors.forename: Leon E
authors.initials: LE
authors.lastname: Barstow
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Enriquez
authors.forename: James
authors.initials: J
authors.lastname: Ranger-Moore
authors.forename: James A
authors.initials: JA
authors.lastname: Ostrem
mesh_terms: D000284:Administration, Oral; D001321:Autistic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M