title: Impact of bilateral pallidal stimulation on DYT1-generalized dystonia in Japanese patients.
abstract: Early-onset generalized dystonia attributable to a DYT1 gene mutation is a hyperkinetic movement disorder that responds poorly to pharmacotherapy. In this video brief, we show that continuous bilateral stimulation of the globus pallidus internus produced sustained and marked improvements in the motor symptoms and functional disabilities of Japanese patients with DYT1-generalized dystonia.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. sgoto@kaiju.medic.kumamoto-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goto
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimazu
authors.forename: Nagako
authors.initials: N
authors.lastname: Murase
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D046690:Deep Brain Stimulation / Q000379:methods*; D004185:Disability Evaluation; D004292:Dominance, Cerebral / Q000502:physiology; D004421:Dystonia / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D007564:Japan; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics*; D018911:Trinucleotide Repeats
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human