title: Comparison of recurrence after vulvectomy and lymphadenectomy with and without sentinel node biopsy in early stage vulvar cancer.
abstract: OBJECTIVE
  To determine the usefulness of sentinel lymph node biopsy in early stage vulvar cancer and to assess recurrences after surgical treatment with sentinel node identification or surgical treatment without sentinel node identification.
  
  
  METHODS
  We reviewed the records of 55 patients with early stage vulvar cancer operated on between 1995 and 2005. A prospective series of 28 patients who underwent vulvectomy and lymphadenectomy with intraoperative sentinel lymph node identification between 2000 and 2005 (SLN group) was compared with a retrospective series of 27 patients who underwent vulvectomy and lymphadenectomy without sentinel node procedure between 1995 and 2000 (non-SLN group). Patients in the sentinel node identification group underwent preoperative lymphoscintigraphy (technetium-99 colloid albumin injection around the tumor) and intraoperative mapping with isosulfan blue dye.
  
  
  RESULTS
  In the SLN group, 9 tumors were T1 and 19 were T2, with a total of 40 groins dissected and 9 positive nodes in 7 patients. Sixty-two sentinel lymph nodes were detected with a mean of 2.2 sentinel nodes per patient (range 0-4). A false negative case was found. In the non-SLN group, 7 tumors were T1 and 20 were T2, with a total of 49 groins dissected and 9 positive nodes in 6 patients. Recurrence occurred in 8 patients (28.6%) in the SLN group and in 6 (26.9%) in the non-SLN group (P=0.8).
  
  
  CONCLUSIONS
  Sentinel lymph node identification in early stage vulvar cancer is a feasible. Analysis of recurrence may allow considering this procedure as a possible alternative to inguino-femoral lymphadenectomy.
authors.affiliation: Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital Materno-infantil Vall d'Hebron, Autonomous University of Barcelona, Spain. jmmartin@vhebron.net
authors.forename: José M
authors.initials: JM
authors.lastname: Martínez-Palones
authors.forename: María A
authors.initials: MA
authors.lastname: Pérez-Benavente
authors.forename: Antonio
authors.initials: A
authors.lastname: Gil-Moreno
authors.forename: Berta
authors.initials: B
authors.lastname: Díaz-Feijoo
authors.forename: Isabel
authors.initials: I
authors.lastname: Roca
authors.forename: Angel
authors.initials: A
authors.lastname: García-Jiménez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aguilar-Martínez
authors.forename: Jordi
authors.initials: J
authors.lastname: Xercavins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005188:False Negative Reactions; D005240:Feasibility Studies; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008499:Medical Records; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000592:standards*; D014846:Vulvar Neoplasms / Q000473:pathology / Q000601:surgery*