title: Microbial transformation of nandrolone decanoate by acremonium strictum.
abstract: Estr-4-en-3,17-dione II, 17beta-hydroxyestr-4-en-3-one III, 15alpha-hydroxyestr-4-en-3,17-dione IV, and 15alpha,17beta-dihydroxyestr-4-en-3-one V were produced by microbial transformation of nandrolone decanoate I in the culture of Acremonium strictum PTCC 5282. Bioconversion characteristics observed were ester hydrolysis, oxidation, and hydroxylation. Each microbial product was purified chromatographically and characterized on the basis of spectral data obtained from (1)H-NMR,( 13)C-NMR, FT-IR, MS, and physical constants such as melting point and optical rotation.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. mtabataba@sina.tums.ac.ir
authors.forename: Mojtaba Tabatabaei
authors.initials: MT
authors.lastname: Yazdi
authors.forename: Seyedeh Maryam
authors.initials: SM
authors.lastname: Zanjanian
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
authors.forename: Amir
authors.initials: A
authors.lastname: Amani
authors.forename: Khosrou
authors.initials: K
authors.lastname: Abdi
mesh_terms: D000164:Acremonium / Q000254:growth & development / Q000378:metabolism*; D000728:Androgens / Q000737:chemistry / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer / Q000379:methods; D006868:Hydrolysis; D015394:Molecular Structure; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D000077603:Nandrolone Decanoate; D010084:Oxidation-Reduction
chemical_list: D000728:Androgens; D009277:Nandrolone; D000077603:Nandrolone Decanoate