title: Synthesis and biological evaluation of isomeric derivatives of naturally occurring spatozoate.
abstract: An isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b-2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. Compound 2g was found to be the most potent cytotoxic agent with a LD50 = 8.98 microg/ml. In a bactericidal assay the compounds showed a broad spectrum of activities. Compound 2a has a very promising fungicidal activity against Microsporum canis.
authors.affiliation: Institut für Organische Chemie der Universität Tübingen, Germany.
authors.forename: Safdar
authors.initials: S
authors.lastname: Hayat
authors.lastname: Atta-ur-Rahman
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Syed Tasadaque Ali
authors.initials: ST
authors.lastname: Shah
authors.forename: Awais
authors.initials: A
authors.lastname: Anwar
authors.forename: M Usman
authors.initials: MU
authors.lastname: Anwar
authors.forename: Ernst
authors.initials: E
authors.lastname: Bayer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Voelter
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001156:Artemia; D001419:Bacteria / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D000459:Phaeophyceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D007202:Indicators and Reagents; C512631:spatozoate