title: Full-dose ifosfamide can be safely administered to outpatients.
abstract: This report compares a traditional full-dose ifosfamide administration modality (24-hr hyperhydration and mesna infusion) with a simplified 9-hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, reducing the currently-recommended prolonged hyperhydration and mesna uroprotection, thus resulting in shorter hospital stays and consequently lower costs.
authors.affiliation: Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Meazza
authors.forename: Gianni
authors.initials: G
authors.lastname: Bisogno
authors.forename: Michela
authors.initials: M
authors.lastname: Casanova
authors.forename: Ilaria
authors.initials: I
authors.lastname: Zanetti
authors.forename: Modesto
authors.initials: M
authors.lastname: Carli
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
mesh_terms: D000293:Adolescent; D000553:Ambulatory Care / Q000379:methods; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage* / Q000009:adverse effects*; D007223:Infant; D015080:Mesna / Q000008:administration & dosage; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D015080:Mesna; D007069:Ifosfamide