title: Should society allow research ethics boards to be run as for-profit enterprises?
abstract: An important mechanism for protecting human research participants is the prior approval of a clinical study by a research ethics board, known in the United States as an institutional review board (IRB). Traditionally, IRBs have been run by volunteer committees of scientists and clinicians working in the academic medical centers where the studies they review are being carried out. However, for-profit organizations are increasingly being hired to conduct ethics reviews. Proponents of for-profit IRBs argue that these IRBs are just as capable as academic IRBs at providing high-quality ethics reviews. Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval.
authors.affiliation: Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States. EEmanuel@cc.nih.gov
authors.forename: Ezekiel J
authors.initials: EJ
authors.lastname: Emanuel
authors.forename: Trudo
authors.initials: T
authors.lastname: Lemmens
authors.forename: Carl
authors.initials: C
authors.lastname: Elliot
mesh_terms: D035843:Biomedical Research / Q000941:ethics*; D026724:Ethical Review; D028744:Ethics Committees, Research / Q000191:economics* / Q000458:organization & administration; D032984:Ethics, Research; D006805:Human Experimentation / Q000941:ethics*; D006801:Humans