Understanding parathyroid hormone action.
In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our work on a select number of those genes.
Partridge
Nicola C
NC
Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 008854, USA. partrinc@umdnj.edu
Li
Xin
X
Qin
Ling
L
D066258:Amphiregulin; D000818:Animals; D001846:Bone Development / Q000502:physiology*; D066255:EGF Family of Proteins; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*
C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D010281:Parathyroid Hormone