In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic information for the development of a putative natural sedative. The 80% methanol extract of Fossilia Mastodi OSSIS given per os at a dose of 3 g/kg in mice showed anxiolysis, potentiation of pentobarbital sleeping time, reduced locomotor activity, and anticonvulsive activity. Fossilia elicited GABA(A) receptor-mediated anxiolysis. The data obtained suggest that the 80% methanol extract of Fossilia Mastodi OSSIS contains some biologically active principles with sedative activity.
Ha
Jeoung-Hee
JH
Department of Pharmacology, School of Medicine, Kyungpook National University, Taegu, Republic of Korea. jhha4834@mail.knu.ac.kr
Lee
Maan-Gee
MG
Chang
Soo-Min
SM
Lee
Jae-Tae
JT
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D005580:Fossils; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008322:Mammals; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital; D010852:Picrotoxin / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects* / Q000502:physiology*; D014020:Tissue Extracts / Q000494:pharmacology*
D003975:Diazepam; D006993:Hypnotics and Sedatives; D010424:Pentobarbital; D010852:Picrotoxin; D014020:Tissue Extracts