Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL.
BACKGROUND
There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy.


RESULTS
Between 1970 and 1998, 433 patients with stage II tongue squamous cell carcinoma were treated by low-dose-rate brachytherapy. This series included 277 patients treated with a linear source with a minimum follow-up of 3 years. A spacer was introduced in 1987. The primary local control rates were 85.6%.


CONCLUSIONS
In the multivariate analysis, an invasive growth pattern was a significant factor for local recurrence. The disease-related survival was influenced by old age and an invasive growth pattern. A spacer lowered mandibular bone complications. The growth pattern was the most important factor for recurrence. Brachytherapy was associated with a high cure rate and the use of spacers brought about good quality of life (QOL).
Oota
Sayako
S
Department of Radiology, Asahi General Hospital, I-1326, Asahi, Chiba, Japan. sayacoral@yahoo.co.jp
Shibuya
Hitoshi
H
Yoshimura
Ryo-ichi
R
Watanabe
Hiroshi
H
Miura
Masahiko
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D002277:Carcinoma / Q000523:psychology / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011788:Quality of Life; D014062:Tongue Neoplasms / Q000523:psychology / Q000532:radiotherapy*; D016896:Treatment Outcome