title: An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension.
abstract: OBJECTIVE
  To evaluate the short-term tolerability of an extended-release preparation of the stimulant medication mixed amphetamine salts (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) whose hypertension has been successfully treated with antihypertensive medications.
  
  
  METHODS
  An 8-week, 2-phase, open-label study design was implemented. All adults had ADHD (DSM-IV diagnosis) and essential hypertension and were required to be normotensive (blood pressure < 135/85 mm Hg, treated) for at least 4 weeks at entry into the study. MAS XR was given for a 6-week period, titrated once each week to a target maximum dose of 60 mg/day given once daily in the morning (phase 1), and then discontinued for 2 weeks at the end of the study (phase 2). At baseline, subjects underwent a comprehensive clinical assessment, medical history, vital signs assessment, and electrocardiogram (ECG). Rating scales were used throughout the study to assess response to treatment, and blood pressure was measured manually at each study visit. The primary outcome was the effect of MAS XR on blood pressure and the development of hypertension.
  
  
  RESULTS
  Thirteen subjects receiving antihypertensive therapy were entered and placed on MAS XR treatment and completed the trial. There were no serious adverse events. No sustained elevated blood pressure (> 140/90 mm Hg at 2 consecutive visits) was observed in the subjects treated with MAS XR. Similar rates of single episodes of hypertension were observed in phases 1 and 2. Similarly, there was no group mean increase in systolic or diastolic blood pressure or pulse during treatment with MAS XR. No clinically significant changes in the ECG were observed. During the 6-week medication phase, significant improvement was found on rating scales assessing ADHD symptoms and severity that reversed with discontinuation of MAS XR.
  
  
  CONCLUSIONS
  The results of this open study suggest that adults with ADHD and controlled hypertension can be safely treated with MAS XR.
authors.affiliation: Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA. twilens@partners.org
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Wilens
authors.forename: Randall M
authors.initials: RM
authors.lastname: Zusman
authors.forename: Paul G
authors.initials: PG
authors.lastname: Hammerness
authors.forename: Amy
authors.initials: A
authors.lastname: Podolski
authors.forename: Julia
authors.initials: J
authors.lastname: Whitley
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Spencer
authors.forename: Martin
authors.initials: M
authors.lastname: Gignac
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
mesh_terms: D000328:Adult; D000367:Age Factors; D000662:Amphetamines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015897:Comorbidity; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000662:Amphetamines; D000959:Antihypertensive Agents; D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; C449521:SLI381