Approaches to lipid metabolism gene identification and characterization in the postgenomic era.
The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future.
Reue
Karen
K
Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. reuek@ucla.edu
Vergnes
Laurent
L
D000818:Animals; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D015894:Genome, Human / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods