Estimation of bulky lymph nodes by power Doppler ultrasound scanning in patients with Hodgkin's lymphoma: a prospective study.
The accuracy of standard methods in estimating bulky lesions requires validation. We used clinical/computed tomography (CT) evaluation and power Doppler ultrasound (US) to detect bulky disease in 137 consecutive Hodgkin's lymphoma patients, and analyzed the prognostic relevance of each method. Bulky disease was detected by clinical/CT evaluation in 47% of the patients and by power Doppler US in 20%. After treatment, at multivariate analysis power Doppler US-selected bulky disease was the parameter that best correlated with freedom from treatment failure (p<0.001). Power Doppler US, a readily available imaging technique, provides a better prognostic classification by detecting true bulky disease more accurately.
Picardi
Marco
M
Department of Biochemistry and Medical Biotechnology, Federico II University Medical School, Naples, Italy.
Ciancia
Rosanna
R
De Renzo
Amalia
A
Montante
Barbara
B
Ciancia
Giuseppe
G
Zeppa
Pio
P
Lobello
Roberto
R
Pane
Fabrizio
F
D'Agostino
Diego
D
Nicolai
Emanuele
E
Sirignano
Cesare
C
Salvatore
Marco
M
Rotoli
Bruno
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D003951:Diagnostic Errors; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000592:standards; D018608:Ultrasonography, Doppler / Q000379:methods* / Q000592:standards