title: COMT genotype and manic symptoms in schizophrenia.
abstract: Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States. pderosse@lij.edu
authors.forename: Pamela
authors.initials: P
authors.lastname: DeRosse
authors.forename: Birgit
authors.initials: B
authors.lastname: Funke
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Burdick
authors.forename: Todd
authors.initials: T
authors.lastname: Lencz
authors.forename: Terry E
authors.initials: TE
authors.lastname: Goldberg
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.forename: Raju
authors.initials: R
authors.lastname: Kucherlapati
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: D002394:Catechol O-Methyltransferase