Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis.
NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. In this report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailed kinetic and structural analyses and highlight important differences, which could be exploited for the design of novel selective antimicrobial drugs.
Magni
Giulio
G
Istituto di Biotecnologie Biochimiche, Università Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy. magnig@univpm.it
Orsomando
Giuseppe
G
Raffaelli
Nadia
N
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009249:NADP / Q000096:biosynthesis*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
D009249:NADP; D017853:Phosphotransferases (Alcohol Group Acceptor); C021844:NAD kinase