title: Clinical evaluation of point-of-care-testing of heart-type fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction.
abstract: The present study was carried out for clinical evaluation of point-of-care-testing (POCT) of heart-type fatty acid-binding protein (H-FABP), Rapicheck H-FABP, for the diagnosis of acute myocardial infarction (AMI), in comparison with conventional cardiac biochemical markers such as myoglobin, creatine kinase isoenzyme MB (CK-MB), and cardiac troponin T. Whole blood samples from patients with confirmed AMI (n = 53), patients with non-AMI cardiac diseases (n = 24), and patients with non-cardiac diseases with chest pain (n = 6) were used. When a test line appeared within 15 min after the addition of 150 microL of whole blood, it was designated to be positive for H-FABP. A control line indicates a proper use of the test. On the other hand, when no test line appeared, it was negative. In the superacute phase of AMI within 3 hours, the diagnostic sensitivity of H-FABP was 93.1%, which was the highest of the four markers compared here. The diagnostic specificity in the phase for H-FABP was 64.3%, while it was 100% with cardiac troponin T. The POCT of H-FABP is thought to be practical for the detection of cardiac damage and effective for the diagnosis of AMI in superacute phase within 3 hours and/or 6 hours.
authors.affiliation: Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Tanaka
authors.forename: Ko-ichi
authors.initials: K
authors.lastname: Sohmiya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kitaura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takeshita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ohkaru
authors.forename: Kumiko
authors.initials: K
authors.lastname: Asayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D052279:Creatine Kinase, MB Form / Q000097:blood; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006331:Heart Diseases / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood; D019095:Point-of-Care Systems; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013997:Time Factors; D020107:Troponin T / Q000097:blood
chemical_list: D000911:Antibodies, Monoclonal; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D009211:Myoglobin; D011933:Reagent Kits, Diagnostic; D020107:Troponin T; D052279:Creatine Kinase, MB Form