Congenital renal rhabdoid tumor with placental metastases: immunohistochemistry, cytogenetic, and ultrastructural findings.
Malignant congenital tumors of fetal origin are rare lesions, the most common type being congenital neuroblastoma. Although prenatal diagnosis is possible in large tumors, occasionally the tumor will be diagnosed first by its metastatic involvement of the placenta. Placental metastases can reflect either maternal or fetal primary sites, and each has relatively specific patterns of placental involvement. We describe the clinical and pathologic features of a widely metastatic congenital renal rhabdoid tumor with its placental and autopsy findings, and include the immunohistochemical, cytogenetic, and ultrastructural features. The pathologic features of the placenta in congenital renal rhabdoid tumor with placental metastasis have not been previously described. The examination of the placenta in this case led to the initial diagnosis and obviated the need for additional diagnostic procedures.
de Tar
Michael
M
InCyte Pathology, PO Box 3405, Spokane, WA 99220-3405, USA. mdetar@incytepathology.com
Sanford Biggerstaff
Julie
J
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000648:ultrastructure; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000737:chemistry / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D008297:Male; D010920:Placenta / Q000737:chemistry / Q000473:pathology*; D010922:Placenta Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000151:congenital / Q000235:genetics / Q000556:secondary*
D014408:Biomarkers, Tumor