title: [HIV infection].
abstract: HIV infection can cause the destruction of cellular immunity. Highly active antiretroviral therapy (HAART) has strong effects to HIV-1 and usually consists of three to four anti-HIV-1 drugs. HAART has caused dramatic change of prognoses in HIV-1 patients. But HAART has several problems to be overcome. IFN-alpha/beta also has anti-HIV-1 effects and single usage of IFN can cause reduction of plasma HIV RNA viral load with about 1 log10 copies/ml after two to eight weeks. IFN can function as an additional anti-HIV-1 drug experimentally, especially to primary or early phase patients and patients with multiple drug resistances.
authors.affiliation: AIDS Clinical Center, International Medical Center of Japan.
authors.forename: Natsuo
authors.initials: N
authors.lastname: Tachikawa
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D007370:Interferon Type I