title: [Spontaneously acquired haemophilia: report of a patient with prostatic adenoma].
abstract: We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.
authors.affiliation: Pharmacie Centrale, Centre Hospitalier de Dunkerque.
authors.forename: F
authors.initials: F
authors.lastname: Barrier
authors.forename: A
authors.initials: A
authors.lastname: de La Guerenne
authors.forename: E
authors.initials: E
authors.lastname: Semjen
authors.forename: L
authors.initials: L
authors.lastname: Wierre
authors.forename: S
authors.initials: S
authors.lastname: Horrent
authors.forename: B
authors.initials: B
authors.lastname: Decaudin
authors.forename: J P
authors.initials: JP
authors.lastname: Resibois
authors.forename: M P
authors.initials: MP
authors.lastname: Weillaert
authors.forename: R
authors.initials: R
authors.lastname: Azar
authors.forename: P
authors.initials: P
authors.lastname: Odou
mesh_terms: D000236:Adenoma / Q000150:complications*; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis; D006406:Hematoma; D006467:Hemophilia A / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000150:complications*; D014227:Triazines
chemical_list: D014227:Triazines; C053507:4-azido-7-phenylpyrazolo-(1,5a)-1,3,5-triazine; D005169:Factor VIII; D017430:Prostate-Specific Antigen