[Critical role of IFN-alpha/beta and IFN-gamma in the regulation of airway inflammation].
Immune balance, which is controlled by IFN-gamma-producing Th1 cells and IL-4-producing Th2 cells, plays a critical role in the regulation of airway inflammation. We have demonstrated that Th1 cells induced neutrophilia, airway hyperresponsiveness (AHR) but not mucus hypersecretion, while Th2 cells induced eosinophilia, AHR and mucus hypersecretion. Here, we indicated that IFN-gamma produced by Th1 cells accelerated neutrophilia and AHR but inhibited eosinophilia and mucus hypersecretion. We also demonstrated an important role of type 1 IFN-alpha/beta during inhibition of Th2-dependent airway inflammation by TLR-9-ligand, CpG-ODN. CpG-ODN-induced IFN-alpha/beta partially appeared to act against Th2 cells to inhibit the production of IL-4 and IL-13, which are key cytokines to regulate the activation and migration of Th2 cells in the lung.
Ashino
Shigeru
S
Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University.
Nishimura
Takashi
T
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D016219:Immunotherapy, Adoptive; D016898:Interferon-alpha / Q000502:physiology*; D016899:Interferon-beta / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology* / Q000627:therapeutic use; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use; D012130:Respiratory Hypersensitivity / Q000276:immunology* / Q000628:therapy; D050800:STAT6 Transcription Factor / Q000502:physiology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D016898:Interferon-alpha; D009838:Oligodeoxyribonucleotides; D050800:STAT6 Transcription Factor; D016899:Interferon-beta; D007371:Interferon-gamma