title: [Extra-articular manifestations of seronegative spondylarthritis].
abstract: Seronegative spondylarthritis are frequently characterised by extra-articular manifestations. They are frequently in recurrent uveitis. Between the cutaneous manifestations should be mentioned erythema nodosum, typical of inflammatory bowel diseases, and keratoderma blenorrhagicum, in the Reiter's syndrome. Cardiac complications in ankylosing spondylitis (AS) include aortic valvular regurgitation and arrhythmia and, more rarely, mitral valvulopathy, cardiomyopathy and pericarditis. Pulmonary involvement in AS includes ventilatory restrictive syndrome and fibro-bullous disease of the apex. Vertebral osteoporosis is a very important extra-articular manifestation because of the possibility of spontaneous fractures of the vertebrae. Central neurological manifestations include medullary compression from cervical sub-luxation while the most important peripheral involvements are lumbar stenosis and the cauda equina syndrome. Type AA amyloidosis is a rare late complication of the AS, possible cause of death especially in patients with aggressive disease. Kidney complications can be observed as consequences of prolonged anti-inflammatory therapy, but the most frequent renal complications are amyloidosis and mesangial IgA segmental and focal glomerulonephritis.
authors.affiliation: Dipartimento di Medicina Interna, D.A.I. Biomedicina, S.O.D. Immunologia, Terapie Cellulari e Patologia Medica IV, Sezione Interna di Reumatologia, Università, Azienda Ospedaliero-Universitaria Careggi, Firenze. d.cammelli@dmi.unifi.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Cammelli
mesh_terms: D000686:Amyloidosis / Q000209:etiology; D016918:Arthritis, Reactive / Q000209:etiology; D004893:Erythema Nodosum / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology; D005922:Glomerulonephritis, IGA / Q000209:etiology; D015796:HLA-B27 Antigen / Q000276:immunology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology; D008171:Lung Diseases / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology; D025241:Spondylarthritis / Q000150:complications* / Q000276:immunology; D014605:Uveitis / Q000209:etiology
chemical_list: D015796:HLA-B27 Antigen