title: Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis.
abstract: BACKGROUND
  Several genes coding for different cytokines may affect host susceptibility to tuberculosis.
  
  
  METHODS
  In the present study, the allele and genotype frequencies of a number polymorphic genes coding for cytokines or cytokine receptors were investigated in Iranian patients with pulmonary tuberculosis (PTB).
  
  
  RESULTS
  From the IL-1 cluster, a positive, significant difference was found at position -889, where the T/T genotype was over represented in PTB patients (p = 0.01); a positive, significant increase was found in the IL1R PstI 1970 C/C genotype, where the C allele was over represented in the PTB patients (p = 0.01). A significant negative association at codon 10 TGF-beta, T allele, was shown in our patients and the C allele and C/C genotype were over represented in the PTB patients (P<0.005). For TNF-alpha at position -238, we found a negative association for the G/A genotype and a positive association for the G/G genotype (p = 0.0009). Significant negative associations at position -590 IL-4, T allele and the T/T genotype were shown in our patients (p = 0.0007); also, the C allele and T/C genotype were significantly increased in our patients (P<0.05). With IL-6 at -174, G/G increased and G/C decreased significantly in the patients (P<0.005).
  
  
  CONCLUSIONS
  Pro-inflammatory cytokines such as TNF-alpha and TGF-beta seem to be decreased, and IL-6 increased in PTB patients.
authors.affiliation: Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. amirzargar_ali@yahoo.com
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Amirzargar
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.forename: Hossein
authors.initials: H
authors.lastname: Jabbari
authors.forename: Abdol-Ali
authors.initials: AA
authors.lastname: Danesh
authors.forename: Farideh
authors.initials: F
authors.lastname: Khosravi
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Hajabdolbaghi
authors.forename: Alireza
authors.initials: A
authors.lastname: Yalda
authors.forename: Behrouz
authors.initials: B
authors.lastname: Nikbin
mesh_terms: D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D020641:Polymorphism, Single Nucleotide; D018121:Receptors, Cytokine / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D016207:Cytokines; D018121:Receptors, Cytokine