title: Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants.
abstract: Amorphous nanoparticles of cefuroxime axetil (CFA), a poorly water-soluble drug, were produced by the controlled nanoprecipitation method without any surfactants at room temperature. The influence of the operation parameters, such as the types of solvent and anti-solvent, the stirring speed, the solvent/anti-solvent (S/AS) volume ratio, the drug concentration and the precipitation temperature, were experimentally investigated. The results indicated that increasing the stirring speed and the S/AS volume, decreasing the drug concentration and the temperature favored to decrease the particle size from 700 to 900 nm to approximately 300 nm. The XRD analyses confirmed that the as-prepared CFA was amorphous nanoparticles. Furthermore, the amorphous CFA nanoparticles exhibited significantly enhanced dissolution property when compared to the commercial spray-dried product. The results demonstrated that the controlled nanoprecipitation method is a direct and feasible technology which could be utilized for preparation of the poorly water-soluble pharmaceutical nanoparticles.
authors.affiliation: Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Ji-Yao
authors.initials: JY
authors.lastname: Zhang
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Shen
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Hu
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Zhong-Qing
authors.initials: ZQ
authors.lastname: Ma
authors.forename: Jimmy
authors.initials: J
authors.lastname: Yun
mesh_terms: D002152:Calorimetry, Differential Scanning; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D012997:Solvents; D013501:Surface-Active Agents; D002444:Cefuroxime; C040738:cefuroxime axetil