title: Cognitive function after on or off pump coronary artery bypass grafting.
abstract: OBJECTIVE
  To investigate cognitive outcome after on and off pump coronary artery bypass grafting.
  
  
  METHODS
  Seventy patients between 50 and 80 years with stable angina pectoris, ejection fraction >30%, serum creatinine <150 micromol/l, and lack of tight main stem stenosis were randomized to on or off pump coronary artery bypass grafting. Standardized neuropsychological tests evaluated attention, verbal and visuo-spatial short-term and working memory, verbal learning, delayed recall, visuo-motor speed, and aspects of executive functions. Levels of anxiety and depression were also investigated. Testing was performed before and at 1 week, 1 and 6 months after surgery.
  
  
  RESULTS
  There was no difference in cognitive impairment (defined as a 20% reduction in at least 20% of the tests) between groups. The incidence at 1 week post-operatively was 57% in the on pump group and 58% in the off pump group, after 1 month 30% and 12% and after 6 months 19% and 15%, respectively (p for interaction=0.19). There was no difference between groups in anxiety (p=0.18) or depression (p=0.48).
  
  
  CONCLUSIONS
  This prospective, randomized study showed no differences in post-operative cognitive function after on pump compared to off pump coronary artery bypass grafting in low risk patients.
authors.affiliation: Department of Cardiothoracic Surgery and Anesthesia, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. jenny.vedin@karolinska.se
authors.forename: Jenny
authors.initials: J
authors.lastname: Vedin
authors.forename: Håkan
authors.initials: H
authors.lastname: Nyman
authors.forename: Anders
authors.initials: A
authors.lastname: Ericsson
authors.forename: Susanne
authors.initials: S
authors.lastname: Hylander
authors.forename: Jarle
authors.initials: J
authors.lastname: Vaage
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000379:methods / Q000523:psychology*; D047549:Coronary Artery Bypass, Off-Pump / Q000523:psychology; D023921:Coronary Stenosis / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies