title: Peritoneal clearance of biochemical markers of bone turnover in children with end stage renal failure on peritoneal dialysis.
abstract: Renal osteodystrophy is one of the important complications in children with end stage renal disease. Non-invasive tools for evaluation of bone metabolism have been proposed in recent years. The aim of this study was to investigate the markers of metabolic bone disease and peritoneal clearance of these markers in children treated with continuous ambulatory peritoneal dialysis (CAPD). In this study, serum osteocalcin (OC) levels were found significantly higher in patients (107.98 +/- 99.99 ng/ml) than in the healthy control group (41.94 +/- 12.94 ng/ml; p<0.05). Mean peritoneal clearance (Clp) of OC was 0.87 +/- 0.91 ml/min. There was no correlation between serum OC and Clp-osteocalcin. There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). There was also a significant correlation between serum ALP and PTH (r=0.714, p=0.0001). A positive correlation was found between serum PTH and Clp of PTH (r=0.471, p=0.009). In conclusion, Clp-osteocalcin is of no interest as a non-invasive marker of metabolic bone disease in children treated with CAPD. But significant correlation between serum OC and PTH, P, and ALP shows that serum OC could be used as a valuable non-invasive biochemical marker of metabolic bone disease.
authors.affiliation: Department of Pediatric Nephrology, Cukurova, University Faculty of Medicine, Turkey.
authors.forename: Aysun K
authors.initials: AK
authors.lastname: Bayazit
authors.forename: Nurcan
authors.initials: N
authors.lastname: Cengiz
authors.forename: Rüksan
authors.initials: R
authors.lastname: Anarat
authors.forename: Aytül
authors.initials: A
authors.lastname: Noyan
authors.forename: Ali
authors.initials: A
authors.lastname: Anarat
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D016723:Bone Remodeling; D016022:Case-Control Studies; D002648:Child; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D016555:Matched-Pair Analysis; D015675:Osteocalcin / Q000097:blood / Q000378:metabolism; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D015415:Biomarkers; D015675:Osteocalcin