title: Enantioselective nitrone cycloadditions of alpha,beta-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes.
abstract: [Structure: see text] Enantioselective nitrone cycloadditions with beta-substituted alpha,beta-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized beta'-hydroxy-beta-amino acid derivatives.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. evans@chemistry.harvard.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Evans
authors.forename: Hyun-Ji
authors.initials: HJ
authors.lastname: Song
authors.forename: Keith R
authors.initials: KR
authors.lastname: Fandrick
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007093:Imidazoles; D009589:Nitrogen Oxides; D009942:Organometallic Compounds; D010080:Oxazoles; D011725:Pyridines; C015388:nitrones; D002563:Cerium; C023666:pyridine