title: Effects of corticoliberin fragment CRF(4-6) on sexual behavior in male rats [corrected].
abstract: Centrally administered doses of the tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) suppressed mating behavior in male rats. Doses of 1 and 2 microg of the tripeptide produced dose-dependent increases in the latent periods of mounting, intromission, and ejaculation. Changes in measures of sexual behavior demonstrated that the corticoliberin fragment CRF(4-6) suppressed both sexual motivation and sexual performance.
authors.affiliation: M. V. Lomonosov Moscow State University, Vorob'evy Gory, 119992 Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Andreev-Andrievskii
authors.forename: D V
authors.initials: DV
authors.lastname: Tsvirkun
authors.forename: E Yu
authors.initials: EY
authors.lastname: Makarenko
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: A A
authors.initials: AA
authors.lastname: Mart'yanov
mesh_terms: D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments; D051381:Rats; D012737:Sex Factors; D012726:Sexual Behavior, Animal / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; D003346:Corticotropin-Releasing Hormone