Transmission of new bovine prion to mice.
We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrP(res). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrP(res) molecular features distinct from BSE.
Baron
Thierry G M
TG
Unité Agents Transmissibles Non Conventionnels, Agence Française de Sécurité Sanitaire des Aliments, Lyon, France. t.baron@lyon.afssa.fr
Biacabe
Anne-Gaëlle
AG
Bencsik
Anna
A
Langeveld
Jan P M
JP
D000818:Animals; D001921:Brain / Q000473:pathology; D002417:Cattle; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D017096:Prion Diseases / Q000635:transmission*; D011328:Prions / Q000472:pathogenicity*
D011328:Prions