title: HIV replication elicits little cytopathic effects in vivo: analysis of surrogate markers for virus production, cytotoxic T cell response and infected cell death.
abstract: Several potential mechanisms for viral destruction of HIV-infected cells have been described. The hypothesis was examined that if HIV were cytopathic, a positive relation between the in vivo virus production or CTL activity and infected cell death should be observed. In a regression analysis no significant relation was found between surrogate markers for in vivo virus production or the virus-specific CTL response and death rates of productively infected cells. In a subgroup of patients the hypothesis is rejected that HIV replication elicits a large (R(2) > 0.25) cytopathic effect (P < 0.05, N = 36). It is concluded that HIV replication elicits little cytopathic effect in productively infected cells and that CD4(+) T lymphocytes are eroded by other mechanisms.
authors.affiliation: Ecology & Evolution, Clausiusstrasse, ETH Zurich Zentrum, Zurich. g.funk@unibas.ch
authors.forename: Georg A
authors.initials: GA
authors.lastname: Funk
authors.forename: Annette
authors.initials: A
authors.lastname: Oxenius
authors.forename: Marek
authors.initials: M
authors.lastname: Fischer
authors.forename: Milos
authors.initials: M
authors.lastname: Opravil
authors.forename: Beda
authors.initials: B
authors.lastname: Joos
authors.forename: Markus
authors.initials: M
authors.lastname: Flepp
authors.forename: Rainer
authors.initials: R
authors.lastname: Weber
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bonhoeffer
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D016923:Cell Death; D003588:Cytopathogenic Effect, Viral; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007963:Leukocytes, Mononuclear; D008962:Models, Theoretical; D012044:Regression Analysis; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D019562:Viral Load; D014779:Virus Replication