title: Versican: signaling to transcriptional control pathways.
abstract: Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease. Versican participates in cell adhesion, proliferation, migration, and angiogenesis, and hence plays a central role in tissue morphogenesis and maintenance. In addition, versican contributes to the development of a number of pathologic processes including atherosclerotic vascular diseases, cancer, tendon remodeling, hair follicle cycling, central nervous system injury, and neurite outgrowth. Versican is a complex molecule consisting of modular core protein domains and glycosaminoglycan side chains, and there are various steps of synthesis and processes regulating them. Also, there is differential temporal and spatial expression of versican by multiple cell types and in different developmental and pathological time frames. To fully appreciate the functional roles of versican as it relates to changing patterns of expression in development and disease, an in depth knowledge of versican's biosynthetic processing is necessary. The goal of this review is to evaluate the current status of our knowledge regarding the transcriptional control of versican gene regulation. We will be focusing on the signal transduction pathways, promoter regions, cis-acting elements, and trans-factors that have been characterized.
authors.affiliation: The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Maziar
authors.initials: M
authors.lastname: Rahmani
authors.forename: Brian W
authors.initials: BW
authors.lastname: Wong
authors.forename: Lisa
authors.initials: L
authors.lastname: Ang
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Cheung
authors.forename: Jon M
authors.initials: JM
authors.lastname: Carthy
authors.forename: Hubert
authors.initials: H
authors.lastname: Walinski
authors.forename: Bruce M
authors.initials: BM
authors.lastname: McManus
mesh_terms: D000818:Animals; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic; D053675:Versicans
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D037181:Lectins, C-Type; C508322:VCAN protein, human; D053675:Versicans