Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10.
Chronic Q fever is characterized by deficient cell-mediated immune response, lack of granulomas, and dysregulation of the cytokine network. Altered transendothelial migration (TM) of peripheral-blood mononuclear cells might account for impaired immune response. TM of lymphocytes and monocytes was decreased in patients with Q fever endocarditis, compared with that in patients recovering from acute Q fever and in control subjects. This defect is related to interleukin (IL)-10, a cytokine involved in the chronic evolution of the disease; neutralizing anti-IL-10 antibodies corrected TM of mononuclear cells from patients with Q fever endocarditis. IL-10 may account for deficient protective immunity in patients with Q fever endocarditis by impairing TM.
Meghari
Soraya
S
Unité des Rickettsies, Centre National de la Recherche Scientifique, Université de la Mediterranée, Institut Fédératif de Recherche 48, Faculté de Médecine, Marseille, France.
Capo
Christian
C
Raoult
Didier
D
Mege
Jean-Louis
JL
D000328:Adult; D000368:Aged; D002465:Cell Movement / Q000276:immunology*; D016997:Coxiella burnetii / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011778:Q Fever / Q000097:blood / Q000276:immunology*
D016753:Interleukin-10