Human plasma DNP level after severe brain injury.
OBJECTIVE
To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea.


METHODS
The peripheral venous plasma as control was collected from 8 volunteers. The peripheral venous plasma from 14 severe brain injury patients were collected in the 1, 3, 7 days after injury. Radioimmunoassay was used to detect the DNP concentration. Meanwhile, daily plasma and urine electrolytes, osmotic pressure as well as 24 h liquid intake and output volume were detected.


RESULTS
The normal adult human plasma DNP level was 62.46 pg/ml+/-27.56 pg/ml. In the experimental group, the plasma DNP levels were higher from day 1 to day 3 in 8 of the 14 patients than those in the control group (P(1)=0.05, P(3)=0.03). Negative fluid balance occurred in 8 patients and hyponatremia in 7 patients. The increase of plasma DNP level was significantly correlated with the development of a negative fluid balance (r =-0.69, P<0.01) and hyponatremia (chi(2) =4.38, P<0.05).


CONCLUSIONS
The increase of plasma DNP level is accompanied by the enhancement of natriuretic and diuretic responses in severe brain-injured patients, which is associated with the development of a negative fluid balance and hyponatremia after brain injury.
Gao
Yi-lu
YL
Department of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China. yilugao@hotmail.com
Xin
Hui-ning
HN
Feng
Yi
Y
Fan
Ji-wei
JW
D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000150:complications; D004546:Elapid Venoms / Q000097:blood*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D036341:Intercellular Signaling Peptides and Proteins; D019586:Intracranial Hypertension / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D014883:Water-Electrolyte Imbalance / Q000097:blood
C075597:Dendroaspis natriuretic peptide; D004546:Elapid Venoms; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011933:Reagent Kits, Diagnostic