Alternative procedure for the synthesis of Mansonone F and Biflorin precursor.
Synthetic studies on Mansonone F and Biflorin are described. Synthesis of ketone 12 has been achieved by utilizing tetrahydronaphthalene 8 which in turn was prepared from the 5-methoxy-alpha-tetralone 3. The conversion of 8 into ketone 12 was accomplished in four steps (O-alkylation with ethyl bromoacetate, dehydrogenation, alkaline hydrolysis and cyclization with phosponate ester).
Ng
Po S Poon
PS
Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Apart. 2182 7, Caracas-1020A, Venezuela.
Banerjee
Ajoy K
AK
D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009284:Naphthols / Q000138:chemical synthesis / Q000737:chemistry; D009285:Naphthoquinones / Q000138:chemical synthesis*; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D044024:Tetralones / Q000737:chemistry
D007659:Ketones; D009284:Naphthols; D009285:Naphthoquinones; D011714:Pyrans; D012717:Sesquiterpenes; D044024:Tetralones; C496018:mansonone F