title: Expression of complement system regulatory molecules in the endometrium of normal ovulatory and hyperstimulated women correlate with menstrual cycle phase.
abstract: The present study describes the temporal expression of complement regulatory molecules membrane cofactor protein (MCP), decay accelerating factor (DAF), CR1, and CD59 in the human endometrium throughout the normal menstrual cycle and in patients submitted to ovarian hyperstimulation. During its proliferative phase, the endometrium expresses MCP, with increased expression during the secretory phase. Phase-dependent expression also was observed for DAF and CD59, mainly in the secretory phase. Expression of CR1 was not detected. These results suggest the presence of complement system activity during the menstrual cycle, with greater expression of regulatory molecules during the secretory phase to protect the epithelial integrity of human endometrium.
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors.forename: Rosana Rita
authors.initials: RR
authors.lastname: Nogawa Fonzar-Marana
authors.forename: Rui Alberto
authors.initials: RA
authors.lastname: Ferriani
authors.forename: Sandro Gomes
authors.initials: SG
authors.lastname: Soares
authors.forename: Florêncio Figueiredo
authors.initials: FF
authors.lastname: Cavalcante-Neto
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Teixeira
authors.forename: José Elpídio
authors.initials: JE
authors.lastname: Barbosa
mesh_terms: D000328:Adult; D018958:CD55 Antigens / Q000378:metabolism*; D018957:CD59 Antigens / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D051916:Membrane Cofactor Protein / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism*; D010060:Ovulation / Q000378:metabolism; D010062:Ovulation Induction; D017463:Receptors, Complement 3b / Q000378:metabolism*
chemical_list: C497857:CD46 protein, human; D018958:CD55 Antigens; D018957:CD59 Antigens; D051916:Membrane Cofactor Protein; D017463:Receptors, Complement 3b; D003165:Complement System Proteins