[Optimization preparation of chansu-loaded solid lipid nanoparticles by central composite design and response surface method].
OBJECTIVE
To optimize the formulation of chansu-loaded solid lipid nanoparticles (Cs-SLN).


METHODS
Cs-SLN was prepared by cold homogenization technique. The effects of influence factors such as the weight of compritol 888 ATO, soybean lecithin and poloxamer 188, on mean diameter, entrapment efficiency, drug loading and overall desirability were investigated by using central composite design and response surface method. The data were imitated using multi-linear equation and second-order polynomial equation.


RESULTS
The latter was prior to the former considering from multiple correlation coefficients. Under the optimal conditions, the mean diameter, entrapment efficiency, drug loading of the Cs-SLN were 71.5 nm, 92.45% and 5.26%.


CONCLUSIONS
The optimized preparation technique for Cs-SLN is stable, feasible and high inclusion rate. It can be used for production of Cs-SLN.
Yang
Yong
Y
Pharmaceutical Division, Shanghai Institute of Pharmaceutical Industry, China.
Feng
Jian-fang
JF
Zhang
Hui
H
Luo
Jie-ying
JY
D000664:Amphibian Venoms / Q000737:chemistry; D000818:Animals; D002018:Bufanolides / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D002025:Bufonidae; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D054709:Lecithins / Q000737:chemistry / Q000302:isolation & purification; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry
D000664:Amphibian Venoms; D002018:Bufanolides; D004337:Drug Carriers; D054709:Lecithins; D008055:Lipids; C095591:chan su; D020442:Poloxamer