title: Stereotactic device for Gamma Knife radiosurgery in experimental animals: technical note.
abstract: OBJECTIVE
  Radiosurgery has become a well-established treatment modality for many intracranial lesions and the information obtained from animal experiments is crucial in devising new strategies with improved efficacy and less risk. We constructed a stereotactic device for rats which can be used for both usual laboratory work and radiosurgery using a Gamma Knife.
  
  
  METHODS
  The stereotactic device was made by modifying the basic design of the ordinary stereotactic frames used for usual laboratory work. It was developed for both Gamma Knife model B and C. An auxiliary tool was also devised which facilitates the placement of the target point at the radiation isocenter.
  
  
  RESULTS
  The reliability of the device was verified by checking the radiation profile and absorbed dose. The results of the experimental irradiation in normal and tumor-cell-inoculated rats demonstrated the usefulness of the device.
  
  
  CONCLUSIONS
  The modified animal stereotactic frame described herein can be used for both the production of experimental animal models and for performing radiosurgery with a common apparatus.
authors.affiliation: Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Im
authors.forename: Do-Hyun
authors.initials: DH
authors.lastname: Nam
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Sang-Gyu
authors.initials: SG
authors.lastname: Ju
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Lim
authors.forename: Jung-Il
authors.initials: JI
authors.lastname: Lee
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004195:Disease Models, Animal; D004867:Equipment Design; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011829:Radiation Dosage; D011859:Radiography; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D051381:Rats; D013238:Stereotaxic Techniques / Q000295:instrumentation*