title: The adjuvant potential of synthetic alkylglycerols.
abstract: Alkylglycerols (AGs) have shown immune stimulant and adjuvant activity in many studies, but natural sources are not so accessible and their extraction from them is very complicated. Therefore, a group of chemists at IFAL have synthesized AG analogs. The aim of this work was to evaluate the adjuvant potential of different synthetic AGs. A mix of ovoalbumin (Ova) and AGs increase anti-Ova IgG antibodies production in sera of immunized mice. The predominant subclass was IgG1 although higher levels of IgG2a were observed as the carbon chain length of AGs increased. AGs also induced the production of IL-12 and nitric oxide (NO) in the U937 human histiocyte and J774 mouse macrophage cell lines, respectively. These results indicate that synthetic AGs are effective adjuvants for the standardized antigen, Ova.
authors.affiliation: Department of Immunology, Finlay Institute, P.O. Box 16017, Havana, Cuba. racevedo@finlay.edu.cu
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Acevedo
authors.forename: Danay
authors.initials: D
authors.lastname: Gil
authors.forename: Judith
authors.initials: J
authors.lastname: del Campo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bracho
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Valdés
authors.forename: Oliver
authors.initials: O
authors.lastname: Pérez
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D005990:Glycerol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006644:Histiocytes / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010047:Ovalbumin / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D010047:Ovalbumin; D005990:Glycerol