title: [Morphological and immunohistogenetical features of colon cancer in children].
abstract: We carried out postmortem and immunohistological studies of 3 cases of colon cancer in a 14-year-old (case 1) and an 8-year-old girl (case 2), and Turcot's syndrome in a 14-year-old girl (case 3). Tumors were located in the proximal portions of the colon and they were of rare histological types. The expression of proteins--the products of MLH 1, MHS2, and MHS6 genes responsible for DNA reparation was estimated. There was no expression of MLH1 and MHS6 in cases 2 and 3, respectively. The findings enabled the authors to assign these cases to hereditary polyposis-unassociated colonic cancer that is also a variety of Turcot's syndrome.
authors.forename: A G
authors.initials: AG
authors.lastname: Talalaev
authors.forename: A S
authors.initials: AS
authors.lastname: Tertychnyĭ
authors.forename: D M
authors.initials: DM
authors.lastname: Konovalov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Val'kov
authors.forename: N S
authors.initials: NS
authors.lastname: Marenich
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D002352:Carrier Proteins / Q000032:analysis*; D002648:Child; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000070957:MutL Protein Homolog 1; D009687:Nuclear Proteins / Q000032:analysis*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D000070957:MutL Protein Homolog 1