Signal processing properties of fast spiking interneurons.
Fast spiking interneurons receive excitatory synaptic inputs from pyramidal cells and a relevant problem is to understand how these cells readout this information. Here this topic is investigated theoretically by using a biophysical modeling of a pair of coupled fast spiking interneuron models. The model predicts, in agreement with the experimental findings, that these cells are capable of transmitting pre-synaptic signals with high temporal precision and transferring high frequency inputs while preserving their relative timing. Moreover, it is shown that a pair of fast spiking interneurons, coupled through both inhibitory and electrical synapses, behaves as a coincidence detector. Lastly, to understand the mechanisms underlying these phenomena, a theoretical analysis is carried out by using a simpler modeling approach.
Di Garbo
Angelo
A
Istituto di Biofisica CNR, Sezione di Pisa, Via G Moruzzi 1, Pisa, Italy. angelo.digarbo@pi.ibf.cnr.it
Barbi
Michele
M
Chillemi
Santi
S
D000818:Animals; D048430:Cell Shape; D007395:Interneurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D051381:Rats; D015398:Signal Transduction; D013997:Time Factors