title: Rapid progression of small cell carcinoma in a renal transplant recipient.
abstract: Immunosuppression is thought to be responsible for the increased incidence of tumor development after organ transplantation. Natural history of these tumors may be more aggressive than would be expected for a similar tumor in a patient without transplant. We describe the fulminant course of small cell carcinoma, likely of prostatic origin, in a kidney transplant patient. Small cell carcinoma (SCC) and especially SCC of the prostate is an aggressive and rare type of tumor. Due to its rarity, only case reports have been published. To our knowledge, this is the first case of SCC, likely of prostatic origin, in an organ transplant recipient (OTR). The case illustrates the aggressiveness of the disease as reflected by its fulminant progression, which may have been further accentuated by the immunosuppression.
authors.affiliation: Department of Urology, Helsinki University Central Hospital, Helsinki, Finland. antti.rannikko@hus.fi
authors.forename: Antti
authors.initials: A
authors.lastname: Rannikko
authors.forename: Leena
authors.initials: L
authors.lastname: Krogerus
authors.forename: Marcus
authors.initials: M
authors.lastname: Nyberg
authors.forename: Kaija
authors.initials: K
authors.lastname: Salmela
authors.forename: Mirja
authors.initials: M
authors.lastname: Ruutu
mesh_terms: D000328:Adult; D018288:Carcinoma, Small Cell / Q000473:pathology*; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000473:pathology* / Q000556:secondary*; D016030:Kidney Transplantation; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*