Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii.
Plasmodium falciparum apical membrane antigen 1 (PfAMA1) coimmunoprecipitates with the Plasmodium homologue of TgRON4, a secreted rhoptry neck protein of Toxoplasma gondii that migrates at the moving junction in association with TgAMA1 during invasion. PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa.
Alexander
David L
DL
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA.
Arastu-Kapur
Shirin
S
Dubremetz
Jean-Francois
JF
Boothroyd
John C
JC
D000818:Animals; D000953:Antigens, Protozoan / Q000378:metabolism*; D006801:Humans; D047468:Immunoprecipitation; D007365:Intercellular Junctions / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008854:Microscopy, Electron; D010963:Plasmodium falciparum / Q000378:metabolism* / Q000648:ultrastructure; D011485:Protein Binding; D015800:Protozoan Proteins / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014122:Toxoplasma / Q000378:metabolism*
D000953:Antigens, Protozoan; D008565:Membrane Proteins; D015800:Protozoan Proteins; C506860:RON4 protein, Toxoplasma gondii; C090077:apical membrane antigen I, Plasmodium