Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens.
Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H-COSY, 1H,13C-gHSQC-1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n=2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results.
Fontana
Gianfranco
G
Dipartimento di Chimica Organica E. Paternò, Università degli Studi di Palermo, Parco d'Orleans 2, I 90128 Palermo, Italy.
Savona
Giuseppe
G
Rodríguez
Benjamín
B
D000107:Acetylation; D002247:Carbon Isotopes / Q000032:analysis; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification; D006859:Hydrogen / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D027544:Salvia / Q000737:chemistry*
D002247:Carbon Isotopes; D045785:Diterpenes, Clerodane; D006859:Hydrogen