Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.
Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.
Palmieri
Giovannella
G
Department of Molecular and Clinical Endocrinology & Oncology, Federico II University, Naples, Italy. giovannella.palmieri@email.it
Selleri
Carmine
C
Montella
Liliana
L
Bulgarelli
Goffredo
G
Vitiello
Laura
L
Merkabaoui
Ghassan
G
Ricci
Patrizia
P
Del Vecchio
Luigi
L
Masci
Annamaria
A
Racioppi
Luigi
L
Rotoli
Bruno
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013945:Thymoma / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology* / Q000628:therapy
D016693:Receptors, Antigen, T-Cell, alpha-beta