Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
Wathier
Michel
M
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Johnson
C Starck
CS
Kim
Terry
T
Grinstaff
Mark W
MW
D016039:Corneal Transplantation; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
D020100:Hydrogels; D010455:Peptides; D011092:Polyethylene Glycols