title: Immune thrombocytopenic purpura associated with pulmonary tuberculosis.
abstract: A 22-year-old woman was admitted into our hospital because of generalized purpura and abnormalities in her chest X-ray. Isolated thrombocytopenia and elevated platelet-associated IgG levels were detected, while the bone marrow examination was normal. Mycobacterium tuberculosis was detected in the bronchoalveolar lavage fluid, and consequently she was diagnosed as having active tuberculosis. High-dose immunoglobulin therapy combined with anti-tuberculosis drugs not only rapidly and continuously corrected thrombocytopenia but also cured pulmonary tuberculosis. This case suggests a causal association between immune thrombocytopenia and tuberculosis as well as the safety and efficacy of the anti-tuberculosis drugs combined with high-dose immunoglobulin therapy.
authors.affiliation: Department of Gastroenterology and Metabology, Toon, Ehime University Graduate School of Medicine.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Tsuro
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kojima
authors.forename: Akira
authors.initials: A
authors.lastname: Mitoro
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshiji
authors.forename: Masao
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Masahito
authors.initials: M
authors.lastname: Uemura
authors.forename: Yoshikawa
authors.initials: Y
authors.lastname: Masahide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukui
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents