Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report.
Osteosclerotic myeloma is a rare plasma cell disorder often associated with a polyneuropathy. We describe a young patient with progressive polyneuropathy associated with vertebral bone marrow lesions and unusual meningeal infiltration at cauda level. The diagnosis of osteosclerotic myeloma was confirmed by bone marrow biopsy findings including the chromosome 13q14 deletion in 37% of the cells. Leptomeningeal involvement was demonstrated by spine magnetic resonance imaging with gadolinium administration and fat-suppression technique.
Mazzeo
Anna
A
Department of Neuroscience, Psychiatry and Anaesthesiology, Neuroradiology Unit, University of Messina, Italy. annamazzeo@yahoo.it
Granata
Francesca
F
Vinci
Sergio
S
Musolino
Caterina
C
Nastasi
Vincenzo
V
Autunno
Massimo
M
Messina
Corrado
C
Vita
Giuseppe
G
Longo
Marcello
M
D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000175:diagnosis*; D009101:Multiple Myeloma / Q000175:diagnosis*; D010026:Osteosclerosis / Q000175:diagnosis*; D016878:POEMS Syndrome / Q000175:diagnosis*
D003287:Contrast Media; D019786:Gadolinium DTPA