No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin.
A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
Hamacher
K
K
Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. k.hamacher@fz-juelich.de
Coenen
H H
HH
D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry / Q000295:instrumentation; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D007650:Ketanserin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
D005462:Fluorine Radioisotopes; C071983:altanserin; D007650:Ketanserin