title: Elemental composition, morphology and mechanical properties of calcified deposits obtained from abdominal aortic aneurysms.
abstract: Calcified deposits exist in almost all abdominal aortic aneurysms (AAAs). The significant difference in stiffness between these hard deposits and the compliant arterial wall may result in local stress concentrations and increase the risk of aneurysm rupture. Calcium deposits may also complicate AAA repair by hindering the attachment of a graft or stent-graft to the arterial wall or cause vessel wall injury at the site of balloon dilation or vascular clamp placement. Knowledge of the composition and properties of calcified deposits helps in understanding the risks associated with their presence. This work presents results of elemental composition, microscopic morphology, and mechanical property measurements of human calcified deposits obtained from within AAAs. The elemental analyses indicate the deposits are composed primarily of calcium phosphate with other assorted constituents. Microscopy investigations show a variety of microstructures within the deposits. The mechanical property measurements indicate an average elastic modulus in the range of cortical bone and an average hardness similar to nickel and iron.
authors.affiliation: Thayer School of Engineering, 8000 Cummings Hall, Dartmouth College, Hanover, NH 03755-8000, USA. marra@dartmouth.edu
authors.forename: Steven P
authors.initials: SP
authors.lastname: Marra
authors.forename: Charles P
authors.initials: CP
authors.lastname: Daghlian
authors.forename: Mark F
authors.initials: MF
authors.lastname: Fillinger
authors.forename: Francis E
authors.initials: FE
authors.lastname: Kennedy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D002130:Calcium Phosphates / Q000378:metabolism; D004548:Elasticity; D004602:Elements; D005260:Female; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged
chemical_list: D002130:Calcium Phosphates; D004602:Elements; C020243:calcium phosphate