[Treatment outcome of patients with multidrug-resistant pulmonary tuberculosis during pregnancy].
OBJECTIVE
To know the treatment outcome of patients with multidrug-resistant tuberculosis (MDR-TB) during gestation.


METHODS
Retrospective study of 3 cases of pregnant women, who were treated for MDR-TB with a regimen including pyrazinamide, ethambutol, para-aminosalicylic acid, cycloserine and amoxicillin-clavulanic acid.


RESULTS
All patients showed a good response to anti-tuberculosis chemotherapy without any serious adverse effect, and were culture-negative at the time of delivery. Two patients delivered vaginally at weeks 40, and one patient delivered surgically at weeks 38. All newborns were healthy, and their tuberculin skin tests and placental tissue examinations were negative for tuberculosis.


CONCLUSIONS
MDR-TB can be successfully treated during pregnancy by using a regimen including effective second-line anti-tuberculosis drugs.
Takashima
Tetsuya
T
Department of Tuberculosis Medicine, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1, Habikino, Habikino-shi, Osaka 583-8588, Japan. takashimat@opho.jp
Danno
Katsura
K
Tamura
Yoshitaka
Y
Nagai
Takayuki
T
Matsumoto
Tomoshige
T
Han
Yuki
Y
Ano
Hiromi
H
Yoshida
Hiroko
H
Kawahara
Kunimitsu
K
Tsuyuguchi
Izuo
I
D000328:Adult; D010131:Aminosalicylic Acid / Q000008:administration & dosage; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000008:administration & dosage*; D003523:Cycloserine / Q000008:administration & dosage; D018432:Drug Resistance, Multiple / Q000235:genetics; D004977:Ethambutol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics; D036801:Parturition; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011718:Pyrazinamide / Q000008:administration & dosage; D012189:Retrospective Studies; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents; D011718:Pyrazinamide; D010131:Aminosalicylic Acid; D019980:Amoxicillin-Potassium Clavulanate Combination; D004977:Ethambutol; D003523:Cycloserine