Pergolide-associated valvular heart disease.
Pergolide is an ergot derivative dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. Ergot derivatives are known to be associated with fibrotic conditions, including a carcinoid-like, fibrotic, valvular heart disease (VHD). Recently, pergolide was identified in association with the development of VHD. This article includes a summary of the literature published on pergolide-associated VHD, a description of the potential mechanisms of drug-induced VHD, and the clinical implications for the management of patients taking pergolide.
Waller
E Andrew
EA
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32256, USA.
Kaplan
Joseph
J
D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D010479:Pergolide / Q000009:adverse effects*; D015995:Prevalence; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012185:Retroperitoneal Fibrosis / Q000139:chemically induced
D018491:Dopamine Agonists; D010479:Pergolide