title: Quantitative measurement of blood-brain barrier permeability using perfusion-CT in extra-axial brain tumors.
abstract: Non-invasive assessment of vascular permeability is of main importance in the diagnosis, treatment and follow-up of intracranial tumors. Perfusion-CT is one of the imaging options available, which affords quantitative assessment of cerebral blood volume and blood-brain barrier permeability. Herein we report two cases of extra-axial tumors studied with perfusion-CT. Comparison with perfusion-MRI was available in one case. High permeability values, as measured by perfusion-CT, reflected the absence of blood-brain barrier in these extra-axial tumors.
authors.affiliation: Universita Cattolica del Sacro Cuore (UCSC), Policlinico Agostino Gemelli, Department of Radiology, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cianfoni
authors.forename: S
authors.initials: S
authors.lastname: Cha
authors.forename: W G
authors.initials: WG
authors.lastname: Bradley
authors.forename: W P
authors.initials: WP
authors.lastname: Dillon
authors.forename: M
authors.initials: M
authors.lastname: Wintermark
mesh_terms: D000369:Aged, 80 and over; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010539:Permeability; D014057:Tomography, X-Ray Computed / Q000379:methods*