Transcription factors that regulate memory in humoral responses.
At least three types of B lymphocytes are important for providing memory in a humoral immune response: 'classical' memory cells that do not secrete immunoglobulin (Ig), long-lived plasma cells (LLPCs) in the bone marrow, and 'innate-like' B-1 cells. In this review, our work on B-lymphocyte-induced maturation protein-1 (Blimp-1), a critical regulator of terminal B-cell differentiation, is discussed in the context of current knowledge of all transcriptional controls that regulate these three types of B cells. Blimp-1 is not required for formation of memory cells, but it is required for them to progress toward becoming plasma cells. Blimp-1 is required for Ig secretion in plasma cells and in B-1 cells. Induction of the activator X-box-binding protein-1 and formation of mu-secreted mRNA depend on Blimp-1 in both cell types. Finally, even after their formation, LLPCs in the bone marrow continue to require Blimp-1 for their maintenance.
Calame
Kathryn
K
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. klc1@columbia.edu
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology*
C513258:Prdm1 protein, mouse; D012097:Repressor Proteins; D051193:Toll-Like Receptors; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1