title: Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex.
abstract: Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.
authors.affiliation: Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. kevin.duffy@dal.ca
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Duffy
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Murphy
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Livingstone
mesh_terms: D000369:Aged, 80 and over; D001766:Blindness / Q000378:metabolism* / Q000473:pathology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D015353:Eye Enucleation; D005260:Female; D005829:Geniculate Bodies / Q000166:cytology / Q000378:metabolism; D006801:Humans; D016900:Neurofilament Proteins / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D009900:Optic Nerve / Q000166:cytology / Q000378:metabolism; D015349:Vision, Monocular / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism*; D014795:Visual Pathways / Q000166:cytology / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins; D003576:Electron Transport Complex IV