Significance of initial emotional state for neuroimmunomodulation in conditions of activation and blockade of 5-HT(1A) receptors.
Experiments performed on male CBA mice immunized with sheep erythrocytes at a dose of 5 x 10(8) cells showed that the selective agonist of serotonin 5-HT(1A) receptors 8-OH-DPAT (1 mg/kg) suppresses the immune response in aggressive animals. In mice demonstrating the submissive type of behavior, formed during 10 days of experience of defeats, activation of 5-HT(1A) receptors with 8-OH-DPAT had no effect on the immune response. However, treatment with the selective 5-HT(1A) receptor blocker WAY-100635 stimulated the immune response, but only in submissive mice. These data lead to the conclusion that activation and blockade of 5-HT(1A) receptors have different effects on the immune response in CBA mice depending on the initial emotional state of the animals, due to different activities of neurotransmitter systems, particularly the serotoninergic, in aggressive and submissive mice.
Idova
G V
GV
Laboratory for the Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk. galina@iph.ma.nsc.ru
Davydova
S M
SM
Cheido
M A
MA
Zhukova
E N
EN
Devoino
L V
LV
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D004291:Dominance-Subordination; D004644:Emotions / Q000502:physiology*; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D012756:Sheep
D010879:Piperazines; D011725:Pyridines; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin