title: Management of neonatal purpura fulminans with severe protein C deficiency.
abstract: Neonatal purpura fulminans is a life threatening clinical entity characterized by extensive subcutaneous thrombosis and disseminated intravascular coagulation usually manifesting shortly after birth. We report an autosomal recessive form of the disease in a neonate who was diagnosed with compound heterozygosity for mutations in his protein C gene as the molecular basis of his disorder.
authors.affiliation: Department of Pediatric Medicine, Park Childrens Center for Treatment and Research, 4 Gorky Terrace, Kolkata 700 019, India. dockrishnasen@gmail.com
authors.forename: Krishna
authors.initials: K
authors.lastname: Sen
authors.forename: Angshumoy
authors.initials: A
authors.lastname: Roy
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D011486:Protein C / Q000627:therapeutic use*; D020151:Protein C Deficiency / Q000150:complications* / Q000235:genetics; D018570:Risk Assessment; D019851:Thrombophilia / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D011486:Protein C