title: Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
abstract: A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.
authors.affiliation: Radiation Oncology Branch, Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1002, USA. martinwb@mail.nih.gov
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Talanov
authors.forename: Celeste A S
authors.initials: CA
authors.lastname: Regino
authors.forename: Hisataka
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Marcelino
authors.initials: M
authors.lastname: Bernardo
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.forename: Martin W
authors.initials: MW
authors.lastname: Brechbiel
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry*; D005453:Fluorescence; D005682:Gadolinium / Q000737:chemistry*; D008198:Lymph Nodes / Q000473:pathology; D046911:Macromolecular Substances / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D049329:Nanostructures; D014054:Tomography / Q000295:instrumentation / Q000379:methods*
chemical_list: D050091:Dendrimers; D046911:Macromolecular Substances; D005682:Gadolinium