Pathological pattern formation and cortical propagation of epileptic seizures.
The stochastic partial differential equations (SPDEs) stated by Steyn-Ross and co-workers constitute a model of mesoscopic electrical activity of the human cortex. A simplification in which spatial variation and stochastic input are neglected yields ordinary differential equations (ODEs), which are amenable to analysis by techniques of dynamical systems theory. Bifurcation diagrams are developed for the ODEs with increased subcortical excitation, showing that the model predicts oscillatory electrical activity in a large range of parameters. The full SPDEs with increased subcortical excitation produce travelling waves of electrical activity. These model results are compared with electrocortical data recorded at two subdural electrodes from a human subject undergoing a seizure. The model and observational results agree in two important respects during seizure: (i) the average frequency of maximum power, and (ii) the speed of spatial propagation of voltage peaks. This suggests that seizing activity on the human cortex may be understood as an example of pathological pattern formation. Included is a discussion of the applications and limitations of these results.
Kramer
Mark A
MA
Program in Applied Science and Technology, University of California, Berkeley, CA 94720-1740, USA.
Kirsch
Heidi E
HE
Szeri
Andrew J
AJ
D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology*; D003198:Computer Simulation; D004569:Electroencephalography; D004594:Electrophysiology; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological