title: Clinical treatment outcomes of periodontal therapy in HIV-seropositive patients undergoing highly active antiretroviral therapy.
abstract: BACKGROUND
  Since the worldwide HIV/AIDS epidemic started, various oral manifestations have been described. However, scientific assessment of therapeutic outcomes of chronic periodontitis in HIV-seropositive patients, in particular undergoing highly active antiretroviral therapy (HAART), has not been addressed.
  
  
  METHODS
  22 patients divided into a HIV-1-seropositve test group and seronegative control group were studied for 12+ months after receiving periodontal therapy by conservative scaling and root planning and maintenance care.
  
  
  CONCLUSIONS
  Periodontal inflammatory parameters improved significantly under the immune reconstituting influence of HAART without major statistical differences in both examination groups. According to this standardized interventional concept, HIV-1-seropositive patients with chronic periodontal disease can be treated successfully. The treatment outcome in maintaining the periodontal attachment is equally well represented in both clinically controlled groups.
authors.affiliation: Department of Conservative Dentistry, Section Community Oral Health, Faculty of Dental Medicine, University of Witten/Herdecke, Alfred-Herrhausen-Str. 50, D-58448 Witten, Germany. andreas.jordan@uni-wh.de
authors.forename: Rainer A
authors.initials: RA
authors.lastname: Jordan
authors.forename: P
authors.initials: P
authors.lastname: Gängler
authors.forename: H-P
authors.initials: HP
authors.lastname: Jöhren
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D016022:Case-Control Studies; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006801:Humans; D010514:Periodontal Pocket / Q000517:prevention & control; D010518:Periodontitis / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome