title: Short communication: quantitative trait loci affecting the somatic cell score on chromosomes 4 and 26 in Italian Holstein cattle.
abstract: This work aimed to confirm previously reported quantitative trait loci (QTL) affecting the somatic cell score (SCS) in dairy cattle on Bos taurus autosomes (BTA) 4 and 26. A granddaughter design with selective genotyping was implemented that included half-sib families from 12 male lines of Italian Holstein cattle. The animals were genotyped for 5 microsatellite markers each on regions of BTA 4 (average marker spacing 9.42 cM) and BTA 26 (average marker spacing 5.26 cM), previously reported by other authors as carrying QTL for somatic cell count. Quantitative trait loci analyses were performed using interval mapping by regressing sire breeding values for SCS onto genotype probabilities at 1-cM intervals along the 2 chromosome regions. Breeding values for SCS were estimated for the whole population using a test-day repeatability animal model. Results were not significant on a chromosome basis, but a possible QTL was found at BM4505 on BTA 26, confirming this region for further studies of QTL affecting SCS in the Italian Holstein population.
authors.affiliation: Istituto di Zootecnia, Facoltà di Medicina Veterinaria, Università di Milano, 20133 Milan, Italy. maria.longeri@unimi.it
authors.forename: M
authors.initials: M
authors.lastname: Longeri
authors.forename: M
authors.initials: M
authors.lastname: Polli
authors.forename: M G
authors.initials: MG
authors.lastname: Strillacci
authors.forename: A B
authors.initials: AB
authors.lastname: Samorè
authors.forename: M
authors.initials: M
authors.lastname: Zanotti
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D002452:Cell Count; D002874:Chromosome Mapping / Q000662:veterinary; D033481:Chromosomes, Mammalian / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D007558:Italy; D008297:Male; D018895:Microsatellite Repeats; D008892:Milk / Q000166:cytology*; D010641:Phenotype; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers