title: Targeted-cryosurgical ablation of the prostate with androgen deprivation therapy: quality of life in high-risk prostate cancer patients.
abstract: OBJECTIVE
  To present preliminary results on health-related quality of life (QoL), prostate-associated symptoms and therapeutic effects of targeted-cryosurgical ablation of the prostate (TCSAP) with androgen deprivation therapy (ADT) in high-risk prostate cancer (PCa) patients.
  
  
  METHODS
  Thirty-four men with high-risk PCa features underwent TCSAP, and ADT was added to improve the treatment outcomes. High-risk parameters were defined as either prostate-specific antigen (PSA) = or > 100ng/mL, or Gleason score = or > 8, or both. The Genito-Urinary Group of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) with prostate-cancer-specific module (QLQ-PR25) was used for evaluating morbidities and PSA levels were recorded every 3 months. PSA failure was defined as the inability to reach a nadir of 0.4 ng/mL or less.
  
  
  RESULTS
  Although it was not statistically significant, the global health status scores increased after TCSAP with ADT. The scores for five functional scales also became higher after treatment. The most prominent symptom after treatment was sexual dysfunction, followed by treatment-related and irritative voiding symptoms.
  
  
  CONCLUSIONS
  TCSAP with ADT appears to be minimally invasive with high QoL except for sexual dysfunction. Long-term follow-up of PSA data and survival is necessary before any conclusions can be made on the efficacy of this promising new therapeutic modality in the treatment of PCa.
authors.affiliation: Department of Urology, Korea University Hospital, Seoul 136-705, Korea.
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Kang
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Bae
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Du-Geon
authors.initials: DG
authors.lastname: Moon
authors.forename: Duck-Ki
authors.initials: DK
authors.lastname: Yoon
authors.forename: Jun
authors.initials: J
authors.lastname: Cheon
authors.forename: Je-Jong
authors.initials: JJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003452:Cryosurgery / Q000379:methods / Q000523:psychology; D004542:Ejaculation; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D007723:Korea; D007989:Libido; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000523:psychology; D011471:Prostatic Neoplasms / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen