Histopathological and immunohistochemical aspects in both basaloid and spindle cell variant of cervical carcinoma.
The study was performed by using a number of eight cases of cervical carcinomas suiting to basaloid carcinomas and spindle cell carcinomas under the circumstances of usual histopathological staining. Immunohistochemically we used anticytokeratin monoclonal antibody (AE1/AE3) to confirm the epithelial differentiation and also PCNA to evaluate the cell proliferation rate. Tumor positiveness for AE1/AE3 cytokeratin cocktail confirmed its epithelial nature. Immunoexpression for PCNA indicated a high index of cell proliferation for all the cases with a more increased value for the basaloid carcinomas.
Drîgnei-Veselu
Daniela
D
Department of Anatomic Pathology, "Victor Babeş" Hospital of Infectious Diseases and Pneumopathology, Craiova. dana_drignei@yahoo.com
Simionescu
Cristiana
C
Georgescu
Claudia Valentina
CV
Bogdan
Fl
F
D000328:Adult; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*
D000911:Antibodies, Monoclonal; D018809:Proliferating Cell Nuclear Antigen; D007633:Keratins