Synthesis with improved yield and study on the analgesic effect of 2-methoxyphencyclidine.
Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a methoxy group has been added to the position 2 of the cyclohexane ring of PCP, the resulting compound is more polar than PCP. This compound was synthesized using an improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-methoxyphencyclidine increased tall-flick latencies as compared to the control group. The maximum analgesic effect of the compound occurred 5-10 min after its injection, while the effect of ketamine was observed 10-25 min after injection.
Ahmadi
Abbas
A
Department of Science, School of Chemistry, Islamic Azad University, Karaj, Iran. abbas_ahmady_3957@yahoo.com
Mahmoudi
Ali
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D007202:Indicators and Reagents; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
C512630:2-methoxyphencyclidine; D000700:Analgesics; D007202:Indicators and Reagents; D007649:Ketamine; D010622:Phencyclidine