Solid lipid nanoparticles incorporated in dextran hydrogels: a new drug delivery system for oral formulations.
Solid lipid nanoparticles (SLN) containing or not (S)-(+)-2-(4-isobutylphenyl)propionic acid (ibuprofen) were prepared with Preciol ATO 5 as lipid phase by the hot homogenization technique and characterized through particle size analyses and zeta potential measurements. DSC experiments carried out on the freeze-dried samples of loaded SLN showed a shift of the melting endotherm of the lipid phase, with the maximum at a temperature value higher then that of the "empty" SLN. (1)H NMR of the nanosuspension allowed to calculate the encapsulation efficiency of the particles that was 52+/-3%. By adding dextran methacrylate (DEX-MA) to the aqueous phase and submitting the mixture to UV irradiation, systems of SLN (drug-loaded and unloaded) incorporated into a dextran hydrogel were prepared. Finally, dissolution studies of ibuprofen from the freeze-dried samples were performed. The comparison among the release profiles of ibuprofen from SLN, DEX-MA hydrogel and SLN/DEX-MA-hydrogel allows to affirm that this last system, retaining about 60% of the drug after 2h in acid medium and releasing it slowly in neutral solution, is suitable for modified delivery oral formulations.
Casadei
Maria Antonietta
MA
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, 00185 Rome, Italy. mariaantonietta.casadei@uniroma1.it
Cerreto
Felice
F
Cesa
Stefania
S
Giannuzzo
Maria
M
Feeney
Michelle
M
Marianecci
Carlotta
C
Paolicelli
Patrizia
P
D000284:Administration, Oral; D002152:Calorimetry, Differential Scanning / Q000379:methods; D003911:Dextrans / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D005612:Freeze Drying; D020100:Hydrogels / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D055672:Static Electricity; D013696:Temperature; D014466:Ultraviolet Rays
D003911:Dextrans; D020100:Hydrogels; D008055:Lipids; D008689:Methacrylates; D007052:Ibuprofen