Vagus nerve stimulation for treatment of epilepsy in Rett syndrome.
This case series presents the outcomes of seven females with Rett syndrome and medically refractory epilepsy who were treated with adjunctive vagus nerve stimulation (VNS) therapy for a minimum of 12 months. Patients ranged in age from 1 to 14 years (median age 9 y) at the time of implantation, had experienced seizures for a median period of approximately 6 years, and had failed at least two trials of antiepileptic drugs before receiving VNS. The median number of seizures per month was 150 (range 12-3600). At 12 months, six females had >or=50% reduction in seizure frequency. VNS was safe and well tolerated, with no surgical complications and no patients requiring explantation of the device. Quality of life outcomes of note among these patients included reports at 12 months of increased alertness among all seven patients. No change in mood or communication abilities was noted.
Wilfong
Angus A
AA
Baylor College of Medicine, Pediatric Neurology, Houston, Texas 77030-2399, USA.
Schultz
Rebecca J
RJ
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D011788:Quality of Life; D015518:Rett Syndrome / Q000150:complications* / Q000628:therapy; D012646:Self Administration; D016896:Treatment Outcome; D014630:Vagus Nerve