Investigations of the possible pharmacological effects of organotin(II) complexes.
Antitumour, antifertility and histopathological investigations were carried out on male rats by the use of organotin complexes. The organotin complexes were synthesized by the alkylation of [Sn(TAML(n))Cl(2)] (n=1-4 and TAML(n) represents the tetraazamacrocyclic ligands) in the presence of CH(3)I or C(2)H(5)Br. The structures of all the complexes have been established on the basis of elemental analyses, conductivity measurements, IR, (1)H NMR, (13)C NMR, (119)Sn NMR and X-ray spectral data. The antitumour effect of the compounds was examined on swiss mice. The results obtained clearly indicated that the compounds, [C(2)H(5)Sn(TAML(3))C(5)H(5)N] and [C(2)H(5)Sn(TAML(4))C(5)H(5)N] display effective antitumour activity. The emphasis has been given on in vivo study on male albino rats (Rattus norvegicus) by performing serum analyses, blood analyses and fertility test.
Chaudhary
Ashu
A
Department of Chemistry, University of Rajasthan, Jaipur 302 004, India.
Singh
A K
AK
Singh
R V
RV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D005298:Fertility; D005303:Fertility Agents, Male / Q000737:chemistry / Q000494:pharmacology*; D007248:Infertility, Male / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D009947:Organotin Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005303:Fertility Agents, Male; D009947:Organotin Compounds