[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease].
L-dopa treatment of Parkinson's disease is complicated in the long term by the appearance of dyskinesia. Hypersensitivity of D1 dopamine receptor has been suggested to play a role in these delayed adverse effects. Hypersensitivity of dopamine D1 receptor in Parkinson's disease can be accounted for by increased levels of Galphaolf, the stimulatory G protein which couples D1 receptor to adenylyl cyclase in the striatum. We here discuss the possible role of D1 receptor signal transduction in the genesis of L-dopa-induced dyskinesia in the light of Galphaolf regulation.
Corvol
J-C
JC
Fédération des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris. Jean.Christophe.corvol@psl.ap-hop-paris.fr
Girault
J-A
JA
Hervé
D
D
D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D003342:Corpus Striatum / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D019204:GTP-Binding Proteins / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D017447:Receptors, Dopamine D1 / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology
D000978:Antiparkinson Agents; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D007980:Levodopa; D000242:Cyclic AMP; D019204:GTP-Binding Proteins